Gene "Gene synonym" Ensembl "Gene description" Uniprot Chromosome Position "Protein class" "Biological process" "Molecular function" "Disease involvement" Evidence "HPA evidence" "UniProt evidence" "NeXtProt evidence" "RNA tissue specificity" "RNA tissue distribution" "RNA tissue specificity score" "RNA tissue specific nTPM" "RNA single cell type specificity" "RNA single cell type distribution" "RNA single cell type specificity score" "RNA single cell type specific nTPM" "RNA cancer specificity" "RNA cancer distribution" "RNA cancer specificity score" "RNA cancer specific FPKM" "RNA brain regional specificity" "RNA brain regional distribution" "RNA brain regional specificity score" "RNA brain regional specific nTPM" "RNA blood cell specificity" "RNA blood cell distribution" "RNA blood cell specificity score" "RNA blood cell specific nTPM" "RNA blood lineage specificity" "RNA blood lineage distribution" "RNA blood lineage specificity score" "RNA blood lineage specific nTPM" "RNA cell line specificity" "RNA cell line distribution" "RNA cell line specificity score" "RNA cell line specific nTPM" "RNA mouse brain regional specificity" "RNA mouse brain regional distribution" "RNA mouse brain regional specificity score" "RNA mouse brain regional specific nTPM" "RNA pig brain regional specificity" "RNA pig brain regional distribution" "RNA pig brain regional specificity score" "RNA pig brain regional specific nTPM" Antibody "Reliability (IH)" "Reliability (Mouse Brain)" "Reliability (IF)" "Subcellular location" "Secretome location" "CCD Protein" "CCD Transcript" "Blood concentration - Conc. blood IM [pg/L]" "Blood concentration - Conc. blood MS [pg/L]" "Blood expression cluster" "Tissue expression cluster" "Cell line expression cluster" "Single cell expression cluster" "Subcellular main location" "Subcellular additional location" "Antibody RRID" "Pathology prognostics - Breast cancer" "Pathology prognostics - Cervical cancer" "Pathology prognostics - Colorectal cancer" "Pathology prognostics - Endometrial cancer" "Pathology prognostics - Glioma" "Pathology prognostics - Head and neck cancer" "Pathology prognostics - Liver cancer" "Pathology prognostics - Lung cancer" "Pathology prognostics - Melanoma" "Pathology prognostics - Ovarian cancer" "Pathology prognostics - Pancreatic cancer" "Pathology prognostics - Prostate cancer" "Pathology prognostics - Renal cancer" "Pathology prognostics - Stomach cancer" "Pathology prognostics - Testis cancer" "Pathology prognostics - Thyroid cancer" "Pathology prognostics - Urothelial cancer" "Tissue RNA - adipose tissue [nTPM]" "Tissue RNA - adrenal gland [nTPM]" "Tissue RNA - amygdala [nTPM]" "Tissue RNA - appendix [nTPM]" "Tissue RNA - basal ganglia [nTPM]" "Tissue RNA - bone marrow [nTPM]" "Tissue RNA - breast [nTPM]" "Tissue RNA - cerebellum [nTPM]" "Tissue RNA - cerebral cortex [nTPM]" "Tissue RNA - cervix [nTPM]" "Tissue RNA - choroid plexus [nTPM]" "Tissue RNA - colon [nTPM]" "Tissue RNA - duodenum [nTPM]" "Tissue RNA - endometrium 1 [nTPM]" "Tissue RNA - epididymis [nTPM]" "Tissue RNA - esophagus [nTPM]" "Tissue RNA - fallopian tube [nTPM]" "Tissue RNA - gallbladder [nTPM]" "Tissue RNA - heart muscle [nTPM]" "Tissue RNA - hippocampal formation [nTPM]" "Tissue RNA - hypothalamus [nTPM]" "Tissue RNA - kidney [nTPM]" "Tissue RNA - liver [nTPM]" "Tissue RNA - lung [nTPM]" "Tissue RNA - lymph node [nTPM]" "Tissue RNA - medulla oblongata [nTPM]" "Tissue RNA - midbrain [nTPM]" "Tissue RNA - ovary [nTPM]" "Tissue RNA - pancreas [nTPM]" "Tissue RNA - parathyroid gland [nTPM]" "Tissue RNA - pituitary gland [nTPM]" "Tissue RNA - placenta [nTPM]" "Tissue RNA - pons [nTPM]" "Tissue RNA - prostate [nTPM]" "Tissue RNA - rectum [nTPM]" "Tissue RNA - retina [nTPM]" "Tissue RNA - salivary gland [nTPM]" "Tissue RNA - seminal vesicle [nTPM]" "Tissue RNA - skeletal muscle [nTPM]" "Tissue RNA - skin 1 [nTPM]" "Tissue RNA - small intestine [nTPM]" "Tissue RNA - smooth muscle [nTPM]" "Tissue RNA - spinal cord [nTPM]" "Tissue RNA - spleen [nTPM]" "Tissue RNA - stomach 1 [nTPM]" "Tissue RNA - testis [nTPM]" "Tissue RNA - thalamus [nTPM]" "Tissue RNA - thymus [nTPM]" "Tissue RNA - thyroid gland [nTPM]" "Tissue RNA - tongue [nTPM]" "Tissue RNA - tonsil [nTPM]" "Tissue RNA - urinary bladder [nTPM]" "Tissue RNA - vagina [nTPM]" "Tissue RNA - white matter [nTPM]" "Cell RNA - A-431 [nTPM]" "Cell RNA - A549 [nTPM]" "Cell RNA - AF22 [nTPM]" "Cell RNA - AN3-CA [nTPM]" "Cell RNA - ASC diff [nTPM]" "Cell RNA - ASC TERT1 [nTPM]" "Cell RNA - BEWO [nTPM]" "Cell RNA - BJ [nTPM]" "Cell RNA - BJ hTERT+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ [nTPM]" "Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [nTPM]" "Cell RNA - CACO-2 [nTPM]" "Cell RNA - CAPAN-2 [nTPM]" "Cell RNA - Daudi [nTPM]" "Cell RNA - EFO-21 [nTPM]" "Cell RNA - fHDF/TERT166 [nTPM]" "Cell RNA - GAMG [nTPM]" "Cell RNA - HaCaT [nTPM]" "Cell RNA - HAP1 [nTPM]" "Cell RNA - HBEC3-KT [nTPM]" "Cell RNA - HBF TERT88 [nTPM]" "Cell RNA - HDLM-2 [nTPM]" "Cell RNA - HEK 293 [nTPM]" "Cell RNA - HEL [nTPM]" "Cell RNA - HeLa [nTPM]" "Cell RNA - Hep G2 [nTPM]" "Cell RNA - HHSteC [nTPM]" "Cell RNA - HL-60 [nTPM]" "Cell RNA - HMC-1 [nTPM]" "Cell RNA - HSkMC [nTPM]" "Cell RNA - hTCEpi [nTPM]" "Cell RNA - hTEC/SVTERT24-B [nTPM]" "Cell RNA - hTERT-HME1 [nTPM]" "Cell RNA - hTERT-RPE1 [nTPM]" "Cell RNA - HUVEC TERT2 [nTPM]" "Cell RNA - JURKAT [nTPM]" "Cell RNA - K-562 [nTPM]" "Cell RNA - Karpas-707 [nTPM]" "Cell RNA - LHCN-M2 [nTPM]" "Cell RNA - MCF7 [nTPM]" "Cell RNA - MOLT-4 [nTPM]" "Cell RNA - NB-4 [nTPM]" "Cell RNA - NTERA-2 [nTPM]" "Cell RNA - OE19 [nTPM]" "Cell RNA - PC-3 [nTPM]" "Cell RNA - REH [nTPM]" "Cell RNA - RH-30 [nTPM]" "Cell RNA - RPMI-8226 [nTPM]" "Cell RNA - RPTEC TERT1 [nTPM]" "Cell RNA - RT4 [nTPM]" "Cell RNA - SCLC-21H [nTPM]" "Cell RNA - SH-SY5Y [nTPM]" "Cell RNA - SiHa [nTPM]" "Cell RNA - SK-BR-3 [nTPM]" "Cell RNA - SK-MEL-30 [nTPM]" "Cell RNA - SuSa [nTPM]" "Cell RNA - T-47d [nTPM]" "Cell RNA - THP-1 [nTPM]" "Cell RNA - TIME [nTPM]" "Cell RNA - U-138 MG [nTPM]" "Cell RNA - U-2 OS [nTPM]" "Cell RNA - U-2197 [nTPM]" "Cell RNA - U-251 MG [nTPM]" "Cell RNA - U-266/70 [nTPM]" "Cell RNA - U-266/84 [nTPM]" "Cell RNA - U-698 [nTPM]" "Cell RNA - U-87 MG [nTPM]" "Cell RNA - U-937 [nTPM]" "Cell RNA - WM-115 [nTPM]" "Blood RNA - basophil [nTPM]" "Blood RNA - classical monocyte [nTPM]" "Blood RNA - eosinophil [nTPM]" "Blood RNA - gdT-cell [nTPM]" "Blood RNA - intermediate monocyte [nTPM]" "Blood RNA - MAIT T-cell [nTPM]" "Blood RNA - memory B-cell [nTPM]" "Blood RNA - memory CD4 T-cell [nTPM]" "Blood RNA - memory CD8 T-cell [nTPM]" "Blood RNA - myeloid DC [nTPM]" "Blood RNA - naive B-cell [nTPM]" "Blood RNA - naive CD4 T-cell [nTPM]" "Blood RNA - naive CD8 T-cell [nTPM]" "Blood RNA - neutrophil [nTPM]" "Blood RNA - NK-cell [nTPM]" "Blood RNA - non-classical monocyte [nTPM]" "Blood RNA - plasmacytoid DC [nTPM]" "Blood RNA - T-reg [nTPM]" "Blood RNA - total PBMC [nTPM]" "Brain RNA - amygdala [nTPM]" "Brain RNA - basal ganglia [nTPM]" "Brain RNA - cerebellum [nTPM]" "Brain RNA - cerebral cortex [nTPM]" "Brain RNA - hippocampal formation [nTPM]" "Brain RNA - hypothalamus [nTPM]" "Brain RNA - medulla oblongata [nTPM]" "Brain RNA - midbrain [nTPM]" "Brain RNA - pons [nTPM]" "Brain RNA - spinal cord [nTPM]" "Brain RNA - thalamus [nTPM]" "Brain RNA - white matter [nTPM]" "Single Cell Type RNA - Adipocytes [nTPM]" "Single Cell Type RNA - Alveolar cells type 1 [nTPM]" "Single Cell Type RNA - Alveolar cells type 2 [nTPM]" "Single Cell Type RNA - Astrocytes [nTPM]" "Single Cell Type RNA - B-cells [nTPM]" "Single Cell Type RNA - Basal keratinocytes [nTPM]" "Single Cell Type RNA - Basal prostatic cells [nTPM]" "Single Cell Type RNA - Basal respiratory cells [nTPM]" "Single Cell Type RNA - Basal squamous epithelial cells [nTPM]" "Single Cell Type RNA - Bipolar cells [nTPM]" "Single Cell Type RNA - Breast glandular cells [nTPM]" "Single Cell Type RNA - Breast myoepithelial cells [nTPM]" "Single Cell Type RNA - Cardiomyocytes [nTPM]" "Single Cell Type RNA - Cholangiocytes [nTPM]" "Single Cell Type RNA - Club cells [nTPM]" "Single Cell Type RNA - Collecting duct cells [nTPM]" "Single Cell Type RNA - Cone photoreceptor cells [nTPM]" "Single Cell Type RNA - Cytotrophoblasts [nTPM]" "Single Cell Type RNA - dendritic cells [nTPM]" "Single Cell Type RNA - Distal enterocytes [nTPM]" "Single Cell Type RNA - Distal tubular cells [nTPM]" "Single Cell Type RNA - Ductal cells [nTPM]" "Single Cell Type RNA - Early spermatids [nTPM]" "Single Cell Type RNA - Endometrial ciliated cells [nTPM]" "Single Cell Type RNA - Endometrial stromal cells [nTPM]" "Single Cell Type RNA - Endothelial cells [nTPM]" "Single Cell Type RNA - Enteroendocrine cells [nTPM]" "Single Cell Type RNA - Erythroid cells [nTPM]" "Single Cell Type RNA - Excitatory neurons [nTPM]" "Single Cell Type RNA - Exocrine glandular cells [nTPM]" "Single Cell Type RNA - Extravillous trophoblasts [nTPM]" "Single Cell Type RNA - Fibroblasts [nTPM]" "Single Cell Type RNA - Gastric mucus-secreting cells [nTPM]" "Single Cell Type RNA - Glandular and luminal cells [nTPM]" "Single Cell Type RNA - granulocytes [nTPM]" "Single Cell Type RNA - Granulosa cells [nTPM]" "Single Cell Type RNA - Hepatic stellate cells [nTPM]" "Single Cell Type RNA - Hepatocytes [nTPM]" "Single Cell Type RNA - Hofbauer cells [nTPM]" "Single Cell Type RNA - Horizontal cells [nTPM]" "Single Cell Type RNA - Inhibitory neurons [nTPM]" "Single Cell Type RNA - Intestinal goblet cells [nTPM]" "Single Cell Type RNA - Ionocytes [nTPM]" "Single Cell Type RNA - Kupffer cells [nTPM]" "Single Cell Type RNA - Langerhans cells [nTPM]" "Single Cell Type RNA - Late spermatids [nTPM]" "Single Cell Type RNA - Leydig cells [nTPM]" "Single Cell Type RNA - Macrophages [nTPM]" "Single Cell Type RNA - Melanocytes [nTPM]" "Single Cell Type RNA - Microglial cells [nTPM]" "Single Cell Type RNA - monocytes [nTPM]" "Single Cell Type RNA - Muller glia cells [nTPM]" "Single Cell Type RNA - NK-cells [nTPM]" "Single Cell Type RNA - Oligodendrocyte precursor cells [nTPM]" "Single Cell Type RNA - Oligodendrocytes [nTPM]" "Single Cell Type RNA - Pancreatic endocrine cells [nTPM]" "Single Cell Type RNA - Paneth cells [nTPM]" "Single Cell Type RNA - Peritubular cells [nTPM]" "Single Cell Type RNA - Plasma cells [nTPM]" "Single Cell Type RNA - Prostatic glandular cells [nTPM]" "Single Cell Type RNA - Proximal enterocytes [nTPM]" "Single Cell Type RNA - Proximal tubular cells [nTPM]" "Single Cell Type RNA - Respiratory ciliated cells [nTPM]" "Single Cell Type RNA - Rod photoreceptor cells [nTPM]" "Single Cell Type RNA - Sertoli cells [nTPM]" "Single Cell Type RNA - Skeletal myocytes [nTPM]" "Single Cell Type RNA - Smooth muscle cells [nTPM]" "Single Cell Type RNA - Spermatocytes [nTPM]" "Single Cell Type RNA - Spermatogonia [nTPM]" "Single Cell Type RNA - Squamous epithelial cells [nTPM]" "Single Cell Type RNA - Suprabasal keratinocytes [nTPM]" "Single Cell Type RNA - Syncytiotrophoblasts [nTPM]" "Single Cell Type RNA - T-cells [nTPM]" "Single Cell Type RNA - Theca cells [nTPM]" "Single Cell Type RNA - Undifferentiated cells [nTPM]" "Single Cell Type RNA - Urothelial cells [nTPM]" A3GALT2 "A3GALT2P, IGB3S, IGBS3S" ENSG00000184389 "Alpha 1,3-galactosyltransferase 2" U3KPV4 1 33306766-33321098 "Enzymes, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at transcript level" "No human protein/transcript evidence" "Evidence at transcript level" "Evidence at transcript level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "HeLa: 1.7" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 20: HeLa - Mitochondria" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "unprognostic (1.86e-2)" "unprognostic (2.36e-2)" "unprognostic (2.39e-1)" "unprognostic (1.18e-1)" "unprognostic (2.61e-3)" "unprognostic (4.96e-2)" "unprognostic (6.83e-2)" "unprognostic (5.81e-2)" "unprognostic (1.23e-1)" "unprognostic (1.89e-1)" "unprognostic (4.90e-8)" "unprognostic (1.17e-1)" "unprognostic (1.12e-2)" "unprognostic (7.87e-2)" 0.1 0.0 0.1 0.1 0.0 0.2 0.0 0.4 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.2 0.0 0.1 0.1 0.0 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 A4GALT "A14GALT, Gb3S, P(k), P1" ENSG00000128274 "Alpha 1,4-galactosyltransferase (P blood group)" Q9NPC4 22 42692121-42721298 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 70.7;Proximal tubular cells: 91.0;Urothelial cells: 74.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 38.7;ASC TERT1: 31.3;RPTEC TERT1: 27.1;TIME: 29.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001141 Uncertain Mitochondria NA NA 22000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 72: Non-specific - Transcription" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" Mitochondria "HPA001141: AB_1078139" "unprognostic (2.59e-2)" "prognostic favorable (2.48e-4)" "unprognostic (2.24e-2)" "unprognostic (4.54e-3)" "unprognostic (7.41e-2)" "unprognostic (1.53e-1)" "unprognostic (8.20e-2)" "unprognostic (2.10e-1)" "unprognostic (2.30e-1)" "unprognostic (1.28e-1)" "unprognostic (4.82e-3)" "unprognostic (4.16e-2)" "unprognostic (1.80e-2)" "unprognostic (1.96e-1)" "unprognostic (8.72e-2)" "unprognostic (3.46e-2)" "unprognostic (2.74e-1)" 41.5 14.3 6.2 6.1 6.0 4.1 31.3 5.0 8.0 29.6 8.0 30.9 4.5 28.1 3.3 30.6 29.2 4.4 77.0 6.2 5.3 51.3 4.3 26.0 6.8 7.8 5.8 7.8 6.2 1.2 16.7 9.1 5.6 35.1 1.7 0.3 36.1 21.3 19.4 20.8 18.2 6.9 6.0 16.2 26.6 6.2 7.1 1.6 25.1 6.3 5.1 38.1 38.2 6.0 1.2 13.6 0.0 0.0 38.7 31.3 20.1 5.5 5.8 1.2 2.1 4.3 2.2 13.6 9.4 9.7 6.7 1.3 12.9 6.5 0.2 0.0 2.7 0.3 21.1 0.5 11.5 0.0 0.9 18.6 1.8 5.5 0.9 1.8 4.7 0.0 0.1 0.0 5.1 19.0 0.0 0.0 1.6 0.9 3.3 0.0 3.0 1.4 27.1 23.4 0.2 0.0 16.9 0.3 0.0 2.4 10.6 1.6 29.3 0.0 2.6 24.3 7.3 2.8 13.1 0.1 5.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.9 0.0 0.0 6.2 6.0 5.0 8.0 6.2 5.3 7.8 5.8 5.6 6.0 7.1 6.0 47.1 0.0 0.5 0.3 1.6 9.2 28.9 70.7 0.0 0.1 4.2 1.5 15.8 1.5 41.2 18.4 0.0 48.7 0.4 0.2 13.7 23.1 0.7 11.1 10.3 43.7 0.0 10.7 0.1 1.1 35.3 43.8 2.6 17.4 1.3 0.2 30.7 0.2 5.3 0.0 0.1 0.0 14.2 1.0 11.8 4.4 46.3 4.0 7.2 7.5 30.0 0.8 0.0 0.5 0.0 3.6 0.0 30.1 0.1 40.1 0.0 91.0 12.1 0.6 39.5 7.6 29.3 0.6 0.6 1.2 8.8 9.4 1.5 19.9 0.1 74.7 AADAT "KAT2, KATII, KYAT2" ENSG00000109576 "Aminoadipate aminotransferase" Q8N5Z0 4 170060222-170091699 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Aminotransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "liver: 67.1" "Cell type enhanced" "Detected in many" "Astrocytes: 22.2;Extravillous trophoblasts: 71.3;Hepatocytes: 29.3;Spermatogonia: 27.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA037502 Enhanced Approved "Vesicles,Plasma membrane" NA NA "Cluster 85: Liver - Metabolism" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 38: Extravillous trophoblasts - Unknown function" "Plasma membrane" Vesicles "HPA037502: AB_10671759" "unprognostic (1.90e-1)" "unprognostic (1.82e-2)" "prognostic favorable (5.59e-4)" "unprognostic (4.21e-2)" "unprognostic (1.30e-1)" "unprognostic (1.06e-1)" "unprognostic (7.41e-2)" "unprognostic (1.03e-2)" "unprognostic (2.97e-2)" "unprognostic (3.38e-2)" "unprognostic (1.23e-2)" "unprognostic (3.55e-1)" "unprognostic (1.35e-1)" "unprognostic (1.23e-2)" "unprognostic (1.39e-1)" "unprognostic (7.28e-3)" "unprognostic (1.17e-2)" 3.3 2.8 6.2 1.9 6.8 0.3 4.7 3.8 9.8 9.8 11.3 6.2 1.6 10.5 5.9 2.6 6.3 3.9 2.7 6.5 6.7 6.8 67.1 4.9 0.7 5.8 5.6 4.7 5.6 6.0 6.1 1.9 6.5 14.4 5.0 11.8 1.7 5.3 4.0 1.4 2.3 7.3 4.8 1.7 3.6 8.2 6.1 1.5 7.5 2.4 0.8 6.4 5.7 8.7 3.5 8.5 25.0 0.0 4.9 18.9 9.0 8.7 4.2 4.9 5.0 8.4 1.0 0.1 1.4 9.8 6.5 2.9 11.3 4.1 3.4 0.0 9.7 0.0 10.0 14.0 3.9 0.1 3.8 7.7 2.5 4.0 5.1 13.5 4.7 11.4 1.5 0.1 19.0 8.9 4.3 0.1 19.0 9.6 7.6 0.0 7.8 0.0 4.4 15.3 20.1 23.5 7.0 1.7 8.5 8.0 0.1 1.7 3.2 12.5 13.4 14.3 13.9 0.1 0.0 0.1 12.5 0.0 15.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.2 6.8 3.8 9.8 6.5 6.7 5.8 5.6 6.5 4.8 6.1 8.7 0.9 0.0 5.9 22.2 0.3 0.9 2.8 0.9 6.2 6.0 3.9 1.0 1.2 1.5 2.1 0.0 2.1 2.8 0.0 0.7 0.0 1.6 0.5 3.7 7.4 0.7 6.7 0.0 15.4 2.2 71.3 3.2 3.1 6.0 0.0 6.2 0.7 29.3 1.6 0.0 13.6 2.8 0.0 0.3 0.9 1.4 1.2 0.4 1.8 5.6 0.0 2.7 0.0 17.6 14.0 1.1 1.6 2.2 0.0 4.0 0.2 8.4 8.5 9.1 6.6 3.9 4.2 14.5 27.1 3.0 0.4 5.6 0.3 3.3 3.1 1.8 AAK1 "DKFZp686K16132, KIAA1048" ENSG00000115977 "AP2 associated kinase 1" Q2M2I8 2 69457997-69674349 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Endocytosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "parathyroid gland: 89.7" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 777.7;Rod photoreceptor cells: 640.8" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in many" 6 "cerebral cortex: 31.0" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017931, HPA020289" Enhanced Approved "Vesicles,Plasma membrane,Cytosol" NA No "Cluster 14: Monocytes - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 15: RT4 - Unknown function" "Cluster 9: Photoreceptor cells - Phototransduction" "Vesicles, Plasma membrane" Cytosol "HPA017931: AB_1844406, HPA020289: AB_1844407" "unprognostic (2.11e-3)" "unprognostic (3.18e-2)" "unprognostic (3.67e-1)" "unprognostic (1.01e-3)" "unprognostic (5.06e-2)" "unprognostic (4.04e-2)" "unprognostic (4.23e-2)" "unprognostic (1.14e-1)" "unprognostic (3.52e-1)" "prognostic unfavorable (3.19e-4)" "unprognostic (1.24e-1)" "unprognostic (7.65e-2)" "unprognostic (4.18e-2)" "unprognostic (1.30e-1)" "unprognostic (5.40e-2)" "unprognostic (6.76e-3)" "unprognostic (1.18e-1)" 9.1 12.6 0.3 8.1 0.6 12.0 8.1 0.9 31.0 7.1 0.0 7.0 4.6 9.9 9.9 7.4 7.5 5.4 20.4 2.9 0.0 10.5 5.1 10.3 9.0 4.7 2.9 5.5 13.1 89.7 13.7 9.9 3.5 8.6 6.3 28.2 6.7 8.2 13.0 6.3 8.5 7.6 0.0 8.6 12.6 6.7 4.8 13.2 23.4 6.7 7.7 7.8 7.1 4.8 25.1 15.3 14.6 12.3 13.7 14.3 41.0 19.4 16.8 12.0 11.3 15.6 10.0 0.9 4.6 27.6 16.5 11.4 11.7 11.4 27.1 20.6 4.4 13.3 9.0 10.0 11.7 9.5 31.3 12.9 9.6 23.7 30.9 10.2 27.4 12.3 3.2 14.1 22.5 3.7 8.8 5.6 6.4 4.9 8.3 5.8 13.8 2.2 10.0 51.0 4.2 6.6 12.0 8.8 10.2 9.9 5.3 12.9 25.6 26.4 17.5 19.7 19.4 12.9 3.9 1.5 23.0 16.0 19.1 1.4 0.5 0.2 1.4 0.2 1.4 0.1 1.3 1.0 0.3 0.3 1.7 1.5 1.5 1.1 2.2 0.2 1.0 0.5 0.3 0.6 0.9 31.0 2.9 0.0 4.7 2.9 3.5 0.0 4.8 4.8 54.6 35.3 34.2 77.7 13.4 15.9 20.8 15.9 32.5 254.4 42.2 40.9 86.7 102.9 19.3 143.5 777.7 81.6 149.1 130.6 43.0 46.0 23.9 36.6 67.4 56.0 72.1 35.3 265.8 67.4 56.3 29.5 44.9 65.7 21.0 24.4 118.2 38.2 62.4 306.2 327.7 31.6 12.2 128.8 23.5 32.7 38.2 67.1 10.6 156.4 72.7 53.2 252.4 147.8 113.9 55.9 76.3 46.6 57.4 42.1 56.0 90.0 10.7 640.8 19.7 26.7 45.5 46.9 59.3 23.3 9.9 213.3 158.1 33.6 21.7 49.0 AANAT SNAT ENSG00000129673 "Aralkylamine N-acetyltransferase" Q16613 17 76453351-76470117 "Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Biological rhythms, Melatonin biosynthesis" "Acyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "retina: 11.0;testis: 4.7" "Cell type enriched" "Detected in some" 10 "Bipolar cells: 302.1" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 2.5;Daudi: 2.0;SCLC-21H: 3.2;U-266/70: 2.3;U-266/84: 2.7;U-698: 3.6" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA054321 Supported Cytosol "Intracellular and membrane" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 56: Bipolar cells - Visual perception" Cytosol "HPA054321: AB_2682449" "unprognostic (7.89e-2)" "unprognostic (2.62e-1)" "unprognostic (1.41e-1)" "unprognostic (2.44e-1)" "unprognostic (1.83e-2)" "unprognostic (2.03e-2)" "unprognostic (1.05e-2)" "unprognostic (3.09e-1)" "unprognostic (1.01e-2)" "unprognostic (3.61e-1)" "unprognostic (9.30e-2)" "unprognostic (4.19e-1)" "unprognostic (2.81e-7)" "unprognostic (1.04e-1)" "unprognostic (6.00e-2)" "unprognostic (4.47e-2)" "unprognostic (1.34e-2)" 0.1 0.2 0.7 1.6 0.7 1.2 0.0 0.8 1.1 0.1 0.2 0.1 0.1 0.1 0.1 0.3 0.2 0.7 0.1 0.9 0.9 0.3 0.0 0.2 1.5 2.1 1.7 0.2 0.2 0.0 0.3 0.0 2.0 0.1 0.0 11.0 0.1 0.0 0.1 1.4 0.4 0.0 1.2 1.0 0.2 4.7 2.1 0.0 0.4 0.0 0.1 0.2 0.1 1.4 0.5 2.5 0.3 0.2 0.0 0.0 0.2 0.0 0.2 0.1 0.0 0.0 1.7 2.0 0.3 0.0 0.3 0.6 0.0 0.0 0.1 0.0 0.6 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.6 0.2 0.0 1.0 0.2 0.3 0.0 0.1 0.6 0.8 0.2 0.1 0.1 1.1 0.0 0.0 3.2 0.2 0.0 0.1 0.8 0.3 1.5 0.3 0.0 0.0 0.9 0.1 0.0 2.3 2.7 3.6 0.6 0.2 0.4 0.7 0.0 0.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.4 0.0 0.3 0.0 0.0 0.7 0.7 0.8 1.1 0.9 0.9 2.1 1.7 2.0 1.2 2.1 1.4 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 302.1 0.1 0.4 0.3 0.0 0.0 0.0 12.5 0.3 0.2 0.0 0.0 0.0 7.5 0.2 0.1 0.6 1.2 0.0 0.9 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.1 6.7 0.6 0.1 0.0 0.3 0.0 19.4 0.3 0.1 0.0 0.0 0.0 13.2 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.1 0.0 0.4 0.0 30.2 0.0 0.0 0.0 3.1 1.1 0.0 0.0 0.1 0.0 0.1 0.1 0.1 AASDHPPT "AASD-PPT, ACPS, CGI-80, LYS5" ENSG00000149313 "Aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase" Q9NRN7 11 106075501-106098699 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in all" 4 "Early spermatids: 388.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA026687 Approved NA NA "Cluster 42: Non-specific - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 1: K-562 - Erythropoiesis" "Cluster 29: Early spermatids - Spermatogenesis" "HPA026687: AB_1844414" "unprognostic (1.96e-2)" "unprognostic (4.40e-1)" "unprognostic (8.71e-3)" "unprognostic (2.12e-1)" "unprognostic (1.11e-1)" "unprognostic (9.04e-3)" "unprognostic (2.82e-3)" "unprognostic (1.41e-1)" "unprognostic (2.44e-2)" "unprognostic (7.92e-2)" "unprognostic (2.09e-1)" "unprognostic (1.32e-1)" "prognostic favorable (4.27e-4)" "unprognostic (2.13e-1)" "unprognostic (2.15e-1)" "unprognostic (1.19e-1)" "unprognostic (1.43e-1)" 16.9 23.5 28.7 18.4 30.7 15.8 21.2 28.1 47.9 17.6 20.9 13.6 13.6 20.3 25.8 21.1 20.6 13.4 27.7 32.1 32.5 34.1 33.6 15.4 22.6 27.5 26.6 20.9 33.3 20.1 11.4 27.9 27.5 18.9 14.0 32.3 24.5 17.1 32.8 17.1 11.9 18.3 29.9 17.3 13.5 37.5 28.2 21.3 22.1 32.4 23.9 18.4 11.6 32.6 29.6 28.2 84.7 63.5 41.4 54.6 34.3 43.1 36.7 58.7 45.0 61.2 53.3 91.4 98.2 28.2 57.2 37.8 77.0 57.6 59.0 55.8 39.3 84.6 19.5 45.0 64.3 73.5 35.2 53.8 72.8 47.0 63.8 40.5 49.6 39.8 95.2 22.2 57.6 16.7 79.8 63.6 36.9 40.2 39.4 55.7 81.3 103.7 70.4 32.5 63.0 58.3 47.5 45.8 43.6 49.1 60.2 50.0 41.9 49.7 47.6 35.3 45.6 30.7 53.7 90.0 22.4 100.0 57.9 63.2 21.6 23.9 20.6 27.9 29.2 26.7 23.9 22.7 21.8 20.8 27.4 26.4 6.9 31.9 28.1 19.2 30.6 18.2 28.7 30.7 28.1 47.9 32.1 32.5 27.5 26.6 27.5 29.9 28.2 32.6 32.4 32.1 31.7 18.3 33.8 20.0 28.2 39.4 56.3 35.0 23.4 31.9 24.1 34.3 29.8 18.4 2.1 78.4 27.7 7.3 39.2 33.5 388.5 31.6 42.2 23.9 18.6 47.9 36.0 24.3 63.8 33.9 23.4 29.4 29.8 41.9 17.2 36.5 39.0 21.9 34.8 12.6 30.5 24.9 13.0 70.2 32.3 27.9 32.0 15.0 29.9 67.4 19.6 32.6 43.4 22.6 10.2 26.7 45.1 23.5 11.1 81.4 47.6 20.0 13.1 30.8 38.2 47.8 37.5 46.2 24.4 39.4 33.1 62.9 13.5 19.6 AATK "AATYK, AATYK1, KIAA0641, LMR1, LMTK1, PPP1R77" ENSG00000181409 "Apoptosis associated tyrosine kinase" Q6ZMQ8 17 81110487-81166221 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "brain: 184.7" "Cell type enriched" "Detected in many" 5 "Oligodendrocytes: 243.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 11 "neutrophil: 2.0" "Lineage enriched" "Detected in single" 11 "granulocytes: 2.0" "Group enriched" "Detected in some" 6 "CACO-2: 60.1;SH-SY5Y: 17.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA009073 Enhanced Uncertain Mitochondria NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 70: Brain - Nervous system development" "Cluster 39: CACO-2 - Unknown function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Mitochondria "HPA009073: AB_1078076" "unprognostic (3.47e-3)" "unprognostic (3.01e-2)" "unprognostic (1.12e-1)" "unprognostic (1.95e-4)" "unprognostic (1.96e-1)" "unprognostic (1.94e-1)" "unprognostic (7.29e-2)" "unprognostic (9.85e-2)" "unprognostic (6.09e-2)" "unprognostic (4.27e-2)" "unprognostic (2.88e-3)" "unprognostic (2.48e-1)" "unprognostic (4.28e-6)" "unprognostic (1.58e-3)" "unprognostic (1.21e-1)" "unprognostic (1.39e-1)" "unprognostic (4.57e-2)" 3.3 4.2 35.4 3.1 79.2 3.7 2.3 43.4 82.0 2.8 0.0 7.7 30.9 0.9 0.5 1.8 2.8 2.7 3.9 30.6 30.8 1.0 0.9 9.5 0.9 99.2 67.9 0.9 20.6 3.0 17.3 2.0 63.4 5.2 0.5 2.1 5.9 3.3 0.6 4.5 23.7 0.8 38.8 9.7 5.8 0.7 78.4 0.1 2.9 1.0 0.2 2.8 4.2 184.7 0.3 0.5 0.7 4.9 0.0 0.0 0.7 0.1 0.0 0.0 0.0 60.1 0.2 0.0 0.3 0.0 0.0 1.2 0.6 0.0 0.0 0.0 2.0 2.2 3.2 2.8 0.1 0.0 3.9 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 1.4 0.0 6.6 0.0 0.2 0.7 0.6 0.3 2.1 4.1 0.6 0.0 0.2 4.5 17.1 0.2 0.4 2.3 0.2 1.1 2.2 2.1 0.4 0.5 0.4 0.0 0.1 0.0 0.0 0.2 1.3 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.1 0.0 0.0 0.0 0.0 35.4 79.2 43.4 82.0 30.6 30.8 99.2 67.9 63.4 38.8 78.4 184.7 6.3 32.1 20.3 17.0 0.3 0.3 1.0 1.9 0.6 43.0 1.3 5.1 2.2 2.8 0.1 0.0 4.2 0.1 0.5 6.8 0.0 0.6 0.0 0.4 0.2 1.8 1.8 0.0 34.6 1.8 0.1 0.5 7.1 0.6 6.3 2.0 1.1 0.1 2.1 21.9 36.0 4.6 0.0 2.8 0.4 0.0 1.5 8.2 5.4 2.8 1.5 9.6 4.1 21.1 243.2 1.1 4.2 2.6 0.1 0.9 34.1 0.9 0.0 4.4 0.0 4.3 0.8 0.4 0.5 0.0 0.3 2.3 1.4 0.4 7.0 0.2 ABAT "GABA-T, GABAT" ENSG00000183044 "4-aminobutyrate aminotransferase" P80404 16 8674596-8784575 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Neurotransmitter degradation" "Aminotransferase, Transferase" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 137.9;kidney: 133.3;liver: 345.6;pancreas: 138.3" "Cell type enhanced" "Detected in many" "Hepatocytes: 268.2;Inhibitory neurons: 95.0;Oligodendrocyte precursor cells: 76.9;Proximal tubular cells: 94.9" "Cancer enhanced" "Detected in all" "glioma: 27.3;liver cancer: 26.8" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "Hep G2: 127.5;MCF7: 81.9;RH-30: 67.4;T-47d: 42.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041528, HPA041690" Enhanced Supported Supported Mitochondria No No 2100000 "Cluster 14: Monocytes - Unknown function" "Cluster 22: Non-specific - Unknown function" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Mitochondria "HPA041528: AB_10795690, HPA041690: AB_10794674" "unprognostic (1.77e-2)" "unprognostic (3.27e-1)" "unprognostic (1.00e-1)" "unprognostic (2.71e-1)" "unprognostic (2.90e-1)" "unprognostic (2.05e-1)" "prognostic favorable (5.36e-5)" "prognostic favorable (5.93e-4)" "unprognostic (1.71e-1)" "unprognostic (1.30e-1)" "unprognostic (1.56e-2)" "unprognostic (1.04e-1)" "prognostic favorable (5.44e-8)" "unprognostic (2.10e-1)" "unprognostic (2.48e-2)" "unprognostic (3.80e-1)" "unprognostic (1.50e-2)" 3.3 27.7 94.6 4.7 105.4 2.2 5.1 85.2 103.4 3.8 70.7 7.6 43.6 3.8 9.6 7.7 6.2 4.4 14.1 90.2 120.7 133.3 345.6 4.5 5.0 90.8 107.4 10.5 138.3 8.2 55.8 3.4 137.6 21.7 7.8 29.6 6.5 3.5 1.6 2.7 20.1 2.7 88.1 4.1 7.4 13.4 137.9 4.2 29.3 1.4 5.9 9.9 4.1 70.9 0.7 0.2 32.1 18.7 5.0 1.7 2.0 4.2 2.2 1.8 0.7 12.7 0.9 4.0 1.4 2.3 1.2 8.3 2.1 7.7 2.4 2.3 2.1 5.5 0.1 127.5 8.1 1.3 8.3 6.5 3.4 3.2 1.4 0.9 0.6 10.7 1.1 2.6 0.6 81.9 2.1 0.6 2.8 23.2 0.3 9.7 67.4 1.8 1.2 20.9 5.1 15.7 1.9 1.0 0.2 6.2 42.6 3.4 0.6 0.8 5.7 2.7 0.1 3.0 0.3 0.8 0.8 5.7 4.2 0.7 1.9 2.7 1.5 2.2 0.7 0.6 1.0 1.1 1.2 1.2 0.7 1.1 6.1 1.2 4.2 0.2 1.1 1.2 94.6 105.4 85.2 103.4 90.2 120.7 90.8 107.4 137.6 88.1 137.9 70.9 1.7 0.0 6.9 39.5 6.1 1.5 4.0 3.3 2.2 27.3 9.1 5.0 10.8 20.0 5.8 1.8 4.2 1.4 5.3 8.9 23.5 1.6 13.0 12.9 6.2 2.4 15.6 13.9 41.8 6.2 1.5 3.2 5.6 12.9 1.3 59.5 7.1 268.2 5.2 35.3 95.0 3.9 2.0 15.7 7.4 8.7 3.7 8.2 1.8 19.7 6.5 48.6 9.2 76.9 17.7 6.8 6.1 4.5 1.0 7.4 15.7 94.9 3.6 5.8 0.0 4.3 3.8 3.7 0.9 9.5 0.6 1.4 6.3 2.3 6.9 5.0 ABHD5 "CGI-58, NCIE2" ENSG00000011198 "Abhydrolase domain containing 5, lysophosphatidic acid acyltransferase" Q8WTS1 3 43690108-43734371 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Differentiation, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Cataract, Deafness, Disease variant, Ichthyosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Syncytiotrophoblasts: 205.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 67.8;neutrophil: 42.5" "Lineage enriched" "Detected in all" 5 "granulocytes: 67.8" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB020685, HPA035851, HPA035852" Approved Supported Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 38: Basophils - Unknown function" "Cluster 31: Skin - Epidermis development" "Cluster 44: HDLM-2 - Immune response" "Cluster 7: Non-specific - Mitochondria" "Vesicles, Cytosol" Nucleoplasm "CAB020685: , HPA035851: AB_10671942, HPA035852: AB_10672073" "unprognostic (2.58e-1)" "unprognostic (2.73e-1)" "prognostic favorable (8.89e-4)" "unprognostic (1.07e-1)" "unprognostic (1.75e-2)" "unprognostic (2.26e-1)" "unprognostic (6.13e-2)" "unprognostic (2.40e-2)" "unprognostic (5.33e-2)" "unprognostic (3.50e-3)" "unprognostic (2.56e-2)" "unprognostic (4.13e-3)" "prognostic favorable (9.17e-5)" "unprognostic (2.48e-1)" "unprognostic (8.87e-2)" "unprognostic (4.18e-2)" "unprognostic (4.18e-2)" 38.8 12.5 6.7 8.5 8.6 39.6 27.9 10.5 8.9 9.8 6.0 12.3 9.9 5.7 4.1 31.1 5.1 11.6 13.4 6.8 7.4 12.0 21.7 16.4 3.4 9.2 8.2 4.6 16.0 12.2 5.6 10.2 9.1 7.1 7.5 6.3 27.4 8.4 15.0 38.0 10.5 9.3 9.3 9.4 12.1 10.8 8.4 6.8 15.5 18.5 7.9 16.7 16.9 11.9 18.9 6.8 8.2 9.7 32.0 12.8 17.1 77.4 27.1 18.8 14.9 9.4 6.4 16.2 10.9 23.2 15.8 5.8 16.5 18.5 22.6 58.4 13.2 36.6 24.4 7.5 15.7 9.2 13.2 13.0 64.6 31.3 28.5 18.8 33.3 10.8 23.9 14.2 46.9 11.0 7.6 6.9 22.8 16.7 20.4 3.1 24.1 8.6 27.9 40.4 10.6 13.6 36.9 20.5 9.8 9.8 18.9 8.9 19.3 18.1 13.6 35.0 34.5 11.1 34.0 7.7 20.3 17.3 16.0 67.8 14.7 9.5 2.3 7.9 1.7 3.5 1.7 2.7 6.8 4.0 1.6 2.5 42.5 2.0 5.7 1.9 4.8 5.3 6.7 8.6 10.5 8.9 6.8 7.4 9.2 8.2 9.1 9.3 8.4 11.9 117.5 25.6 51.8 12.7 44.8 39.9 27.5 25.9 88.8 11.9 149.9 116.2 10.3 14.3 49.6 27.6 27.1 16.7 80.3 65.0 33.2 57.5 19.5 47.5 49.0 34.6 36.2 69.0 24.1 61.5 24.9 53.7 67.8 114.0 16.5 8.8 18.2 12.7 18.0 3.3 24.1 23.7 34.6 44.1 17.4 17.1 5.3 79.8 7.2 11.2 35.9 11.0 12.3 18.1 28.8 75.2 49.8 5.7 41.8 25.5 98.5 39.8 19.1 17.4 0.0 32.0 46.4 47.3 41.9 111.7 40.9 205.4 42.6 15.2 21.9 71.6 ABL1 "ABL, c-ABL, JTK7, p150" ENSG00000097007 "ABL proto-oncogene 1, non-receptor tyrosine kinase" P00519 9 130713016-130887675 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Apoptosis, Autophagy, Cell adhesion, DNA damage, DNA repair, Endocytosis" "DNA-binding, Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Microglial cells: 71.2;Oligodendrocytes: 116.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002686, HPA027251, HPA027280, HPA028409" Supported Enhanced "Nucleoplasm,Nuclear bodies" Yes No "Cluster 37: B-cells - Transcription" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 1: K-562 - Erythropoiesis" "Cluster 50: Fibroblasts - ECM organization" Nucleoplasm "Nuclear bodies" "CAB002686: , HPA027251: AB_1844453, HPA027280: AB_1844454, HPA028409: AB_10601011" "unprognostic (4.82e-2)" "unprognostic (3.99e-2)" "unprognostic (5.55e-2)" "unprognostic (4.72e-2)" "unprognostic (1.16e-1)" "unprognostic (1.46e-1)" "unprognostic (3.75e-3)" "unprognostic (1.89e-3)" "unprognostic (2.34e-1)" "unprognostic (2.54e-2)" "unprognostic (1.09e-2)" "unprognostic (1.48e-1)" "unprognostic (3.96e-3)" "unprognostic (1.10e-2)" "unprognostic (1.47e-1)" "unprognostic (1.22e-1)" "unprognostic (1.06e-1)" 50.9 30.7 27.4 25.3 38.9 23.4 45.8 33.6 31.4 60.5 40.4 96.4 23.1 63.0 11.6 33.8 55.6 35.7 36.1 26.6 28.3 23.1 17.5 37.3 16.3 39.3 38.5 56.0 24.9 32.5 34.9 26.5 35.8 43.5 26.7 14.2 32.4 33.6 29.4 36.3 45.2 41.2 31.3 23.3 51.6 20.1 34.9 22.4 46.7 30.8 15.4 79.3 42.7 41.3 22.5 48.3 53.6 62.9 76.5 93.3 18.8 38.8 60.4 44.8 38.1 36.4 28.3 32.3 22.3 52.0 47.6 42.5 23.5 36.0 30.7 20.6 16.3 23.7 84.1 33.4 51.8 36.5 32.3 68.8 37.2 80.6 50.0 64.1 61.0 47.9 135.8 26.5 54.9 42.0 49.2 30.5 57.9 34.3 33.8 55.9 67.9 35.9 45.0 25.7 47.9 60.1 66.1 23.5 29.2 31.0 46.2 33.1 71.1 170.7 44.1 66.3 62.6 8.4 20.3 47.9 72.1 27.6 55.1 0.0 0.7 0.3 0.6 0.4 0.8 1.3 0.6 0.6 0.7 0.4 0.6 0.5 0.0 0.8 1.9 1.0 0.3 0.6 27.4 38.9 33.6 31.4 26.6 28.3 39.3 38.5 35.8 31.3 34.9 41.3 16.2 9.6 13.6 54.9 4.7 9.2 7.3 9.8 5.2 8.2 11.6 10.2 6.2 7.2 7.2 14.7 12.5 13.6 12.1 21.2 1.9 14.4 5.9 8.6 29.7 18.1 22.1 4.6 52.5 11.1 4.3 36.7 5.6 12.4 2.5 22.1 20.3 15.9 16.6 10.1 63.7 17.5 6.1 16.4 11.7 8.8 28.0 10.2 5.4 71.2 6.6 19.2 6.2 66.9 116.0 17.9 18.3 25.6 5.6 8.6 11.6 10.3 7.8 9.1 19.7 29.5 19.8 16.9 16.5 6.6 6.8 15.2 7.9 20.1 21.4 7.2 ABL2 "ABLL, ARG" ENSG00000143322 "ABL proto-oncogene 2, non-receptor tyrosine kinase" P42684 1 179099330-179229684 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Cell adhesion" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 166.8;Langerhans cells: 188.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in all" "hTERT-HME1: 73.5;TIME: 70.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001866, CAB017106, HPA072754" Uncertain Approved Nucleoplasm,Vesicles NA NA "Cluster 6: Non-specific - Transcription" "Cluster 57: Non-specific - Angiogenesis" "Cluster 17: WM-115 - Nervous system development" "Cluster 41: Macrophages - Immune response" Nucleoplasm Vesicles "CAB017106: , HPA001866: AB_1078082, HPA072754: AB_2732212" "unprognostic (3.05e-1)" "prognostic unfavorable (3.50e-4)" "unprognostic (1.07e-1)" "unprognostic (4.71e-2)" "unprognostic (9.45e-2)" "unprognostic (8.23e-3)" "unprognostic (1.91e-2)" "unprognostic (4.81e-3)" "unprognostic (1.26e-1)" "unprognostic (6.98e-2)" "unprognostic (1.12e-1)" "unprognostic (3.73e-1)" "prognostic unfavorable (1.78e-7)" "unprognostic (4.76e-2)" "unprognostic (4.14e-2)" "unprognostic (6.08e-2)" "prognostic unfavorable (8.40e-4)" 9.3 3.2 5.9 4.9 6.7 2.7 5.7 6.1 6.1 5.4 2.0 4.6 2.8 3.7 2.7 2.5 3.2 11.8 3.9 7.4 5.0 3.6 2.7 6.5 2.7 3.8 4.4 3.5 5.7 4.2 3.8 4.1 3.9 3.5 3.3 9.2 3.5 2.6 3.1 4.2 3.2 4.5 3.0 2.7 3.7 4.4 5.6 4.1 3.8 4.2 2.5 6.4 4.0 4.8 24.2 13.1 8.7 5.8 7.3 16.8 5.3 26.3 21.6 31.9 23.1 9.9 7.2 13.7 18.9 19.2 21.7 11.0 12.6 9.1 44.6 8.5 11.4 6.7 12.4 4.9 13.3 7.5 2.1 15.6 11.6 45.3 73.5 13.9 36.2 7.0 16.1 3.8 42.6 6.5 5.9 4.0 8.3 5.0 4.3 8.6 14.4 6.5 10.8 4.0 5.2 11.9 22.0 7.0 53.8 13.2 6.2 6.4 70.7 33.3 24.5 15.7 42.8 7.0 9.3 14.1 15.6 4.0 32.4 1.4 0.3 0.0 0.5 0.1 0.2 0.5 0.3 0.3 0.2 0.7 0.4 0.5 0.6 0.5 0.1 0.5 0.2 0.1 5.9 6.7 6.1 6.1 7.4 5.0 3.8 4.4 3.9 3.0 5.6 4.8 33.5 22.4 24.0 44.1 14.4 46.9 43.6 16.3 12.5 40.0 18.7 9.5 8.9 22.8 10.8 11.0 166.8 9.3 7.7 15.5 11.7 14.3 15.6 12.3 23.4 67.2 27.0 9.9 81.6 13.9 8.2 67.6 10.2 21.5 17.1 19.5 31.1 15.3 22.9 25.2 62.0 11.0 10.2 34.9 188.1 32.2 15.2 67.7 69.4 45.0 13.9 11.3 8.2 72.4 57.1 45.5 16.0 13.5 10.3 42.6 9.9 9.4 11.0 35.7 6.6 32.3 30.5 17.8 30.5 11.5 38.4 10.4 12.4 11.6 14.9 25.3 ACAA1 ENSG00000060971 "Acetyl-CoA acyltransferase 1" P09110 3 38103129-38137242 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" "Acyltransferase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 4 "kidney: 212.6;liver: 659.3" "Cell type enhanced" "Detected in all" "Distal enterocytes: 356.8;Hepatocytes: 686.0;Proximal enterocytes: 441.1;Proximal tubular cells: 721.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "OE19: 224.0;SK-BR-3: 342.9" "Low region specificity" "Detected in all" "HPA006764, HPA007244" Enhanced Supported Peroxisomes NA NA 4700000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 85: Liver - Metabolism" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Peroxisomes "HPA006764: AB_1078085, HPA007244: AB_1078084" "prognostic favorable (3.00e-4)" "unprognostic (5.57e-2)" "unprognostic (4.54e-2)" "prognostic favorable (7.53e-4)" "unprognostic (2.63e-1)" "prognostic favorable (1.23e-4)" "unprognostic (9.35e-3)" "unprognostic (2.91e-2)" "unprognostic (8.11e-2)" "unprognostic (2.22e-1)" "unprognostic (2.24e-1)" "unprognostic (4.90e-1)" "prognostic favorable (6.99e-9)" "unprognostic (1.72e-1)" "unprognostic (1.99e-1)" "unprognostic (2.50e-2)" "unprognostic (1.65e-2)" 42.8 54.1 47.5 24.0 54.4 44.7 41.2 54.3 49.5 28.3 42.3 56.9 101.0 20.8 44.6 56.7 19.4 29.8 84.8 44.6 48.7 212.6 659.3 34.9 26.1 54.2 50.4 20.9 59.3 47.9 24.8 17.2 53.0 55.1 51.2 4.9 38.9 25.3 48.2 30.7 89.5 18.7 50.9 41.3 42.1 15.5 53.6 28.0 32.1 53.8 30.0 43.7 33.5 54.9 35.5 39.8 13.0 40.7 55.6 32.2 44.6 32.2 47.0 36.3 34.5 52.8 38.8 21.1 22.6 52.0 17.4 24.5 34.9 54.0 20.0 31.0 37.2 27.0 35.4 155.5 35.3 63.3 59.8 59.0 39.3 31.2 22.5 23.9 49.9 49.7 26.2 24.2 41.3 49.2 60.3 45.3 13.3 224.0 47.0 13.9 25.0 34.3 103.4 110.4 10.9 16.5 31.7 342.9 23.7 18.0 35.1 48.9 36.8 21.9 21.1 43.2 44.2 31.9 21.7 16.1 34.8 54.4 34.7 79.9 114.4 130.4 48.8 159.1 41.2 33.9 45.7 47.4 178.1 36.0 45.2 42.5 76.3 71.9 187.7 104.5 77.2 82.1 47.5 54.4 54.3 49.5 44.6 48.7 54.2 50.4 53.0 50.9 53.6 54.9 30.7 41.7 38.7 50.6 45.6 33.3 56.5 57.6 40.9 36.9 48.7 37.1 3.2 98.7 44.3 66.2 14.6 91.6 61.7 356.8 166.3 98.0 4.5 40.7 38.6 25.4 55.1 40.4 25.6 78.4 64.5 34.4 76.5 39.1 19.0 32.5 37.1 686.0 81.7 8.4 24.7 73.1 48.8 93.5 86.8 9.6 35.8 83.2 58.7 14.0 89.5 43.1 53.5 12.5 30.9 100.9 270.6 33.1 44.5 60.6 441.1 721.8 26.3 16.7 32.9 28.5 27.4 19.8 11.7 48.1 35.5 99.3 44.4 186.7 84.3 87.0 ACAA2 DSAEC ENSG00000167315 "Acetyl-CoA acyltransferase 2" P42765 18 49782164-49813953 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" "Acyltransferase, Hydrolase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 1011.9" "Cell type enhanced" "Detected in all" "Distal enterocytes: 331.1;Hepatocytes: 810.5;Proximal tubular cells: 708.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA042303 Approved Supported Mitochondria NA NA 3800000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Mitochondria "HPA042303: AB_10794046" "unprognostic (7.94e-2)" "unprognostic (3.14e-2)" "unprognostic (2.20e-3)" "prognostic unfavorable (8.53e-4)" "unprognostic (2.92e-2)" "unprognostic (2.28e-2)" "unprognostic (7.63e-2)" "unprognostic (1.70e-1)" "unprognostic (7.97e-2)" "unprognostic (8.03e-3)" "unprognostic (1.72e-1)" "unprognostic (3.84e-1)" "prognostic favorable (1.36e-10)" "unprognostic (1.39e-1)" "unprognostic (2.24e-1)" "unprognostic (8.26e-3)" "unprognostic (3.41e-1)" 126.3 74.2 56.9 44.4 64.9 32.5 79.1 63.7 63.9 24.9 68.4 168.7 170.0 29.0 29.8 30.3 24.4 46.9 223.7 53.2 59.8 378.2 1011.9 48.9 36.6 65.1 61.4 34.8 54.1 35.1 34.9 29.6 64.0 26.4 109.6 31.9 20.3 34.0 165.3 28.0 165.2 44.5 62.8 33.6 37.4 37.7 64.3 39.9 55.8 236.6 31.9 41.6 28.6 64.2 3.9 70.5 110.0 97.5 129.9 69.5 57.4 35.2 52.4 53.6 41.2 146.3 58.9 61.1 73.5 117.5 56.7 4.8 176.8 21.0 51.4 190.5 50.4 45.5 79.0 171.4 62.5 0.7 78.3 91.7 6.7 84.8 26.2 44.6 90.0 87.7 42.5 54.7 147.5 81.8 2.7 89.7 101.5 24.8 26.7 150.8 233.0 217.6 177.7 2.8 163.4 130.9 2.7 76.2 5.6 82.1 45.7 60.0 48.1 49.8 60.5 67.8 36.4 112.3 139.7 157.3 35.0 85.7 47.1 53.0 87.4 96.1 99.2 106.5 123.0 43.2 58.3 88.7 103.2 36.3 50.2 73.2 8.3 120.0 108.1 50.1 76.4 112.7 56.9 64.9 63.7 63.9 53.2 59.8 65.1 61.4 64.0 62.8 64.3 64.2 28.4 38.5 47.3 11.8 31.4 3.6 14.2 15.5 11.4 6.7 25.0 25.5 189.9 234.4 23.7 55.2 4.2 36.5 48.2 331.1 295.4 148.5 71.2 7.9 33.9 30.0 40.1 53.6 1.7 45.7 56.0 47.3 23.9 7.7 45.1 63.3 41.4 810.5 109.6 1.7 4.6 73.0 24.4 64.8 18.5 153.9 48.1 50.6 19.6 13.1 57.2 62.2 106.1 4.5 8.7 101.8 161.2 37.2 41.2 9.8 226.6 708.0 26.4 29.5 19.7 42.1 34.9 51.1 42.7 11.1 4.8 27.0 52.2 93.0 144.8 9.6 ACAT1 "ACAT, THIL" ENSG00000075239 "Acetyl-CoA acetyltransferase 1" P24752 11 108116695-108147603 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" "Acyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "kidney: 622.7;liver: 969.5" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 508.4;Distal tubular cells: 698.5;Hepatocytes: 663.4;Proximal tubular cells: 1484.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RPMI-8226: 420.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004428, HPA007569" Enhanced Enhanced Mitochondria NA NA 1400000 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 8: Non-specific - Mitochondria" "Cluster 25: RPMI-8226 - Immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Mitochondria "HPA004428: AB_1078088, HPA007569: AB_1844482" "unprognostic (3.70e-3)" "unprognostic (2.23e-2)" "unprognostic (7.84e-3)" "unprognostic (4.65e-2)" "unprognostic (3.05e-2)" "unprognostic (1.12e-1)" "prognostic favorable (1.43e-5)" "unprognostic (3.59e-3)" "unprognostic (1.26e-1)" "unprognostic (5.20e-2)" "unprognostic (2.64e-2)" "unprognostic (1.13e-2)" "prognostic favorable (0.00e+0)" "unprognostic (1.96e-1)" "unprognostic (1.68e-1)" "unprognostic (8.06e-2)" "unprognostic (6.62e-3)" 135.4 151.3 45.2 24.3 45.3 38.4 56.9 47.1 60.1 41.0 91.8 96.3 103.9 44.0 34.1 45.0 39.1 25.6 289.4 42.7 46.8 622.7 969.5 43.7 28.2 44.8 45.2 64.7 110.6 95.9 30.9 24.7 45.2 45.6 85.6 26.2 104.1 60.2 461.1 45.3 53.2 57.1 46.7 29.3 81.9 66.3 45.6 19.1 65.5 410.8 29.7 44.1 34.6 47.7 76.9 57.7 48.2 139.3 155.9 138.7 25.1 71.7 78.8 77.7 91.7 168.1 77.3 41.3 116.8 83.6 119.7 78.1 142.3 70.3 83.3 84.9 114.6 117.4 64.6 163.9 107.6 112.9 64.9 124.6 77.1 69.2 127.4 91.5 85.0 92.3 172.1 61.8 128.6 45.8 57.4 122.4 48.2 103.1 135.0 88.1 96.9 420.4 114.7 50.4 75.7 88.1 111.6 152.7 83.0 37.0 132.2 97.6 87.4 83.2 44.5 73.5 88.8 18.9 57.8 77.7 37.6 233.1 59.6 1.4 17.1 4.7 25.3 25.5 29.9 29.2 28.8 30.0 33.5 13.8 25.5 22.4 1.8 13.4 27.8 11.3 35.7 23.4 45.2 45.3 47.1 60.1 42.7 46.8 44.8 45.2 45.2 46.7 45.6 47.7 50.5 54.5 91.8 17.9 37.2 43.1 52.2 48.9 23.9 30.1 34.6 29.6 508.4 78.6 33.5 104.8 27.1 39.9 29.2 125.0 698.5 43.1 345.7 62.2 42.1 62.5 30.0 74.7 35.1 60.5 41.5 57.1 29.0 25.7 27.8 48.6 99.2 663.4 97.9 38.7 37.8 38.5 97.6 73.6 27.8 65.3 66.5 39.1 58.7 30.0 50.1 39.1 25.7 22.6 26.5 33.8 93.8 82.4 52.7 27.8 51.4 1484.0 101.8 28.8 65.7 54.2 69.2 172.7 27.2 39.2 48.4 25.2 38.1 61.6 84.5 24.4 ACAT2 ENSG00000120437 "Acetyl-CoA acetyltransferase 2" Q9BWD1 6 159762045-159779112 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 6 "liver: 231.3" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 262.1;Early spermatids: 187.0;Exocrine glandular cells: 176.6;Hepatocytes: 214.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB021106, HPA025736, HPA025765, HPA025811" Enhanced Approved Nucleoplasm,Cytosol NA NA 14000000 "Cluster 44: Non-specific - Transcription" "Cluster 85: Liver - Metabolism" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Cytosol Nucleoplasm "CAB021106: AB_10058215, HPA025736: AB_1844487, HPA025765: AB_1844485, HPA025811: AB_1844488" "unprognostic (3.31e-1)" "unprognostic (2.44e-2)" "prognostic favorable (1.12e-4)" "prognostic unfavorable (7.25e-4)" "unprognostic (1.38e-1)" "unprognostic (2.03e-1)" "unprognostic (9.25e-2)" "unprognostic (4.76e-2)" "unprognostic (1.43e-1)" "unprognostic (2.58e-1)" "unprognostic (1.21e-1)" "unprognostic (1.59e-1)" "prognostic unfavorable (7.38e-4)" "unprognostic (1.39e-1)" "unprognostic (1.50e-2)" "unprognostic (8.56e-2)" "unprognostic (2.54e-2)" 10.9 21.6 22.2 18.5 24.4 22.4 23.6 30.2 30.0 12.8 20.1 38.5 31.2 10.9 40.0 32.6 11.4 10.6 9.4 22.7 27.6 27.0 231.3 20.2 25.0 39.4 26.3 17.3 9.4 12.5 3.2 11.8 39.1 35.6 33.8 19.5 15.5 9.3 4.9 18.1 17.9 15.8 24.8 9.7 19.5 28.6 24.4 39.4 9.0 7.1 36.7 13.7 9.1 28.1 70.1 58.8 451.9 160.8 57.2 111.6 14.4 57.4 70.5 141.8 244.5 234.0 87.1 55.9 29.0 48.7 458.2 64.5 174.8 465.8 166.7 35.2 174.4 127.4 97.2 418.8 62.0 81.4 35.8 62.2 40.1 231.1 92.9 21.4 68.8 160.1 139.9 104.3 85.5 113.0 137.0 154.0 142.8 65.5 41.7 83.9 94.4 173.1 377.2 93.7 107.8 63.2 67.5 43.3 26.2 18.5 83.4 157.3 39.2 50.3 45.7 72.1 154.0 47.7 89.0 142.0 15.7 151.2 77.1 30.1 24.9 46.7 47.9 33.9 47.3 46.6 54.1 47.8 34.7 51.4 53.3 43.2 11.0 41.3 23.6 30.4 79.0 46.2 22.2 24.4 30.2 30.0 22.7 27.6 39.4 26.3 39.1 24.8 24.4 28.1 11.8 12.8 45.4 15.3 25.8 26.1 32.4 262.1 22.2 19.4 33.4 24.5 1.2 42.9 115.5 20.2 2.1 53.7 28.6 34.7 70.5 78.8 187.0 14.3 9.9 18.8 17.2 38.5 14.3 176.6 97.0 21.6 9.7 25.9 13.3 47.7 16.1 214.8 58.1 13.5 14.7 23.6 83.4 14.8 29.8 128.8 13.7 25.7 30.2 1.0 58.9 22.5 30.9 13.0 17.5 65.6 28.8 19.2 25.5 38.7 15.4 50.0 30.1 24.7 0.0 25.1 44.9 28.5 45.6 43.0 21.0 35.2 31.0 102.5 33.0 38.9 ACLY "ACL, ATPCL, CLATP" ENSG00000131473 "ATP citrate lyase" P53396 17 41866917-41930542 "Cancer-related genes, Citric acid cycle related proteins, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism" Transferase "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007783, HPA022434, HPA022953, HPA022959, HPA028758" Enhanced Supported Nucleoplasm,Cytosol No No 3100000 "Cluster 44: Non-specific - Transcription" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 29: Early spermatids - Spermatogenesis" Cytosol Nucleoplasm "CAB007783: AB_562242, HPA022434: AB_1844513, HPA022953: AB_1844514, HPA022959: AB_1844515, HPA028758: AB_10603575" "unprognostic (2.21e-2)" "prognostic unfavorable (1.79e-4)" "unprognostic (1.41e-1)" "unprognostic (1.21e-2)" "unprognostic (2.83e-1)" "unprognostic (8.94e-3)" "prognostic unfavorable (3.66e-4)" "unprognostic (3.38e-3)" "unprognostic (4.11e-2)" "unprognostic (5.94e-3)" "unprognostic (2.13e-2)" "unprognostic (3.01e-2)" "unprognostic (3.88e-3)" "unprognostic (1.66e-1)" "unprognostic (9.36e-2)" "unprognostic (3.90e-2)" "unprognostic (4.67e-3)" 64.9 30.2 24.0 43.9 27.2 34.7 46.7 33.6 55.5 33.2 22.5 35.4 49.3 34.4 34.7 30.5 36.0 31.1 27.1 24.7 66.5 47.5 27.5 35.3 42.7 80.3 48.6 21.3 46.3 37.4 22.4 42.4 76.5 62.6 35.7 23.2 39.1 28.5 15.3 28.9 43.7 42.5 34.2 39.1 38.9 32.2 43.1 48.4 30.8 14.9 40.3 36.7 29.2 43.7 127.1 423.2 194.8 168.8 296.1 274.4 178.3 174.0 188.0 213.7 266.3 217.9 141.8 204.7 108.8 245.2 200.6 197.2 253.9 298.0 177.8 184.9 243.0 117.3 228.3 227.5 136.9 191.9 147.1 219.8 88.3 376.9 75.6 140.0 228.7 155.0 147.4 158.5 180.4 130.0 317.8 107.6 127.6 84.8 75.7 205.2 236.2 262.2 221.0 222.4 364.7 200.2 124.5 382.8 133.7 167.6 229.4 181.0 248.4 165.7 135.5 169.0 291.0 91.9 127.0 193.0 280.3 145.7 137.5 32.2 29.2 36.5 30.9 30.9 29.1 21.6 24.4 27.7 33.0 18.3 18.1 20.3 14.6 24.0 39.8 19.1 34.3 33.8 24.0 27.2 33.6 55.5 24.7 66.5 80.3 48.6 76.5 34.2 43.1 43.7 28.2 28.9 26.2 12.4 20.5 25.0 10.0 25.4 12.5 12.1 38.6 21.6 12.6 31.5 21.0 23.9 4.2 22.6 25.9 26.7 11.7 33.8 73.3 31.6 35.3 33.4 65.9 34.3 10.9 33.6 46.5 28.9 23.4 29.2 15.2 28.7 41.4 53.0 31.0 18.5 14.7 54.0 20.3 39.0 25.9 17.5 61.8 27.6 32.0 16.9 42.9 7.6 25.7 11.6 13.6 42.9 16.2 51.1 17.4 35.9 40.4 87.0 31.1 9.4 13.1 17.6 25.7 17.9 36.0 21.6 33.0 22.2 25.1 49.0 22.2 15.5 ACVR1 "ACVR1A, ACVRLK2, ALK2, SKR1" ENSG00000115170 "Activin A receptor type 1" Q04771 2 157736444-157876330 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Microglial cells: 106.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "T-reg: 6.6" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007505, HPA046514" Approved Uncertain Nucleoli,Cytosol NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 89: Fibroblasts - ECM organization" "Cluster 30: Epithelial cell lines - Translation" "Cluster 50: Fibroblasts - ECM organization" Nucleoli Cytosol "HPA007505: AB_1844752, HPA046514: AB_2732526" "unprognostic (6.99e-2)" "unprognostic (3.32e-2)" "unprognostic (3.02e-1)" "unprognostic (1.19e-2)" "unprognostic (2.73e-1)" "unprognostic (6.09e-2)" "unprognostic (3.66e-3)" "unprognostic (1.08e-1)" "unprognostic (3.99e-1)" "unprognostic (3.20e-1)" "unprognostic (2.65e-2)" "unprognostic (4.29e-2)" "unprognostic (2.42e-1)" "unprognostic (3.43e-3)" "unprognostic (3.17e-1)" "unprognostic (1.76e-2)" "prognostic unfavorable (5.17e-4)" 20.8 10.4 17.3 12.9 12.7 1.8 18.8 14.0 15.4 28.1 17.4 16.5 10.9 24.4 32.7 11.3 17.0 24.2 19.7 26.3 12.8 26.4 22.7 17.5 8.8 13.7 12.9 21.2 10.0 8.5 10.9 17.6 13.7 15.1 12.6 6.3 18.8 15.3 21.5 13.9 10.5 34.5 12.6 8.3 14.7 5.2 16.3 7.5 40.5 13.3 8.2 20.9 15.5 11.8 6.1 13.1 14.4 18.5 65.0 70.6 18.9 43.4 71.3 33.7 36.1 10.1 13.4 0.2 18.2 45.6 32.3 16.9 10.5 22.5 36.8 43.0 8.7 25.7 7.2 14.4 54.7 2.0 28.5 89.5 41.4 69.8 84.2 42.8 38.7 6.7 9.5 6.7 45.2 11.1 0.4 0.4 21.4 8.7 21.7 4.1 19.6 5.7 45.4 24.5 12.4 14.9 17.0 9.7 64.5 22.2 5.3 7.0 54.0 50.9 16.8 25.3 17.1 4.7 3.5 0.3 52.2 1.6 58.1 2.9 1.7 0.1 0.5 1.0 0.7 0.8 4.9 1.3 1.3 0.2 1.6 0.7 0.2 1.2 1.4 1.4 6.6 1.1 17.3 12.7 14.0 15.4 26.3 12.8 13.7 12.9 13.7 12.6 16.3 11.8 9.6 9.6 9.0 22.9 1.8 9.8 7.7 12.6 12.5 10.4 8.0 9.8 12.7 11.5 12.4 7.3 0.0 8.4 1.1 4.8 5.9 9.9 1.0 5.9 12.9 17.3 4.2 1.7 34.0 17.8 5.3 20.3 8.2 6.5 5.1 4.2 18.2 13.3 7.0 3.3 34.2 4.5 24.4 13.0 8.7 2.0 20.2 7.6 3.6 106.8 5.5 6.6 2.1 42.3 22.9 17.2 4.1 15.8 6.4 13.0 3.7 15.5 13.6 2.1 13.1 16.3 19.3 0.4 2.7 4.0 7.5 10.5 4.3 3.5 4.3 8.8 ACVR1B "ActRIB, ACVRLK4, ALK4, SKR2" ENSG00000135503 "Activin A receptor type 1B" P36896 12 51951699-51997078 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "eosinophil: 3.9" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB026126, HPA063761" Approved Approved Cytosol NA NA "Cluster 46: Basophils - DNA binding" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 39: CACO-2 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "CAB026126: , HPA063761: AB_2685115" "unprognostic (8.66e-2)" "unprognostic (5.72e-2)" "unprognostic (1.16e-1)" "unprognostic (3.23e-3)" "unprognostic (2.34e-1)" "unprognostic (2.54e-1)" "unprognostic (1.21e-3)" "unprognostic (1.00e-1)" "unprognostic (7.68e-2)" "unprognostic (5.29e-2)" "unprognostic (2.56e-1)" "unprognostic (2.37e-1)" "unprognostic (4.52e-2)" "unprognostic (9.02e-2)" "unprognostic (6.60e-2)" "unprognostic (8.96e-2)" "unprognostic (4.79e-2)" 16.5 10.3 20.7 10.0 20.8 13.5 13.2 13.6 23.4 13.9 9.1 24.6 28.2 8.8 18.0 20.9 15.3 12.2 10.1 21.5 13.3 34.3 29.9 14.7 6.4 12.5 13.9 9.4 40.7 52.7 14.7 11.1 13.1 14.0 24.4 17.4 32.8 15.3 13.1 45.6 26.1 8.1 9.5 8.8 24.9 15.7 16.1 7.6 11.4 8.8 7.4 12.6 18.8 18.3 11.4 24.3 18.6 10.3 20.9 16.2 10.5 12.6 14.2 13.1 9.9 49.5 17.1 5.0 17.2 13.8 14.6 19.6 17.8 15.2 13.5 7.3 21.0 12.3 5.9 15.6 23.8 19.9 43.8 32.0 19.4 14.8 18.6 13.9 18.7 17.7 13.3 14.9 11.8 23.2 19.1 17.2 18.0 24.0 8.5 10.2 14.4 6.4 37.2 17.0 23.5 19.5 13.6 19.2 9.0 13.1 21.1 12.8 12.0 9.0 13.6 10.2 6.1 9.0 6.8 6.7 9.7 9.4 11.8 2.5 1.2 3.9 0.3 1.8 0.5 0.0 0.3 0.3 0.7 0.2 0.8 0.4 1.0 0.0 2.2 0.3 0.5 0.3 20.7 20.8 13.6 23.4 21.5 13.3 12.5 13.9 13.1 9.5 16.1 18.3 8.0 3.2 13.4 8.1 2.9 18.6 10.1 9.2 23.3 45.3 11.3 8.6 5.9 17.2 12.0 25.8 29.2 0.7 2.0 49.7 3.9 17.7 2.9 12.3 8.1 10.9 24.6 0.8 34.8 14.4 0.8 12.6 19.9 9.0 11.4 9.4 17.9 24.4 4.0 37.0 30.2 28.7 2.0 16.7 5.3 8.4 9.9 10.0 7.2 9.4 10.1 8.8 1.0 21.6 11.3 13.3 22.1 9.4 2.3 15.1 31.8 17.0 15.8 24.5 6.6 17.5 12.2 3.8 16.5 17.7 25.3 0.5 4.6 5.6 24.7 15.5 ACVR1C "ACVRLK7, ALK7" ENSG00000123612 "Activin A receptor type 1C" Q8NER5 2 157526767-157628864 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Apoptosis "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "adipose tissue: 31.3;brain: 10.2" "Cell type enhanced" "Detected in many" "Excitatory neurons: 26.2;Leydig cells: 31.7;Oligodendrocytes: 55.8;Proximal enterocytes: 17.7" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "ASC diff: 10.9;HDLM-2: 5.1" "Low region specificity" "Detected in all" "Region enhanced" "Detected in many" "basal ganglia: 29.7" "HPA007982, HPA011933" Uncertain "Intracellular and membrane" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 57: Non-specific - Angiogenesis" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "HPA007982: AB_1078134, HPA011933: AB_1844754" "unprognostic (1.03e-1)" "unprognostic (4.55e-2)" "unprognostic (9.65e-2)" "unprognostic (1.22e-1)" "unprognostic (2.92e-1)" "unprognostic (7.64e-2)" "unprognostic (1.00e-1)" "unprognostic (3.48e-1)" "unprognostic (1.01e-1)" "unprognostic (1.35e-1)" "unprognostic (7.12e-3)" "unprognostic (3.62e-1)" "unprognostic (9.31e-6)" "unprognostic (7.28e-2)" "unprognostic (1.95e-1)" "unprognostic (9.74e-2)" "unprognostic (1.30e-1)" 31.3 2.5 3.2 0.6 6.3 0.1 6.2 1.3 3.5 0.5 0.0 4.1 4.1 0.1 0.3 0.2 0.1 0.3 0.4 6.4 10.2 0.4 2.2 0.2 0.5 1.4 1.9 3.6 1.5 0.0 2.2 0.1 1.3 0.2 3.0 0.4 0.8 0.3 0.8 0.3 3.4 0.2 0.9 0.1 2.1 0.4 6.6 0.2 0.2 0.3 0.3 0.1 0.2 3.8 1.5 0.0 0.0 0.1 10.9 0.3 0.2 0.3 0.3 0.1 0.3 1.7 0.2 0.0 0.1 0.9 0.7 0.0 0.1 0.0 0.2 5.1 0.7 0.0 0.0 0.4 0.0 0.0 0.8 0.1 0.0 0.3 0.0 0.3 0.0 0.0 0.0 0.3 0.3 0.2 0.0 0.0 1.0 0.0 0.5 0.0 0.6 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.8 0.2 0.0 0.2 0.0 0.6 0.2 0.0 0.1 0.6 1.9 0.0 0.5 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.2 0.1 0.4 0.2 0.0 0.1 0.6 0.2 0.0 0.0 0.0 0.0 0.0 0.1 3.2 6.3 1.3 3.5 6.4 10.2 1.4 1.9 1.3 0.9 6.6 3.8 0.5 0.0 1.1 14.7 1.4 0.6 0.7 0.9 1.8 0.8 0.9 0.3 1.9 0.0 0.9 0.0 0.0 0.2 0.3 14.3 0.0 0.2 1.9 0.4 4.9 0.7 7.8 0.0 26.2 0.2 0.8 0.9 2.6 0.5 0.0 0.4 1.1 5.9 0.1 0.0 11.0 9.2 2.0 0.0 1.3 2.9 31.7 0.1 3.6 3.7 4.3 1.8 0.0 3.5 55.8 0.4 7.6 9.1 2.9 1.8 17.7 1.1 0.2 0.3 0.0 0.6 0.8 0.4 2.4 0.7 1.4 0.3 2.5 0.4 13.5 0.5 ACVR2A "ACTRII, ACVR2" ENSG00000121989 "Activin A receptor type 2A" P27037 2 147844517-147930826 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted membrane proteins" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 62.5;Inhibitory neurons: 63.4;Oligodendrocyte precursor cells: 84.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HHSteC: 26.3;RH-30: 23.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA046997 Approved Approved Cytosol NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 31: Skin - Epidermis development" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Cytosol "HPA046997: AB_10970077" "unprognostic (4.55e-2)" "unprognostic (2.26e-2)" "unprognostic (2.09e-1)" "unprognostic (7.34e-3)" "unprognostic (2.75e-1)" "unprognostic (1.17e-1)" "unprognostic (4.41e-3)" "unprognostic (8.73e-3)" "unprognostic (1.30e-2)" "unprognostic (3.61e-1)" "unprognostic (1.34e-2)" "unprognostic (1.52e-1)" "prognostic favorable (1.62e-4)" "unprognostic (1.16e-1)" "unprognostic (1.40e-1)" "unprognostic (3.95e-1)" "unprognostic (3.99e-2)" 7.3 4.0 6.2 4.6 7.4 3.3 7.0 10.8 6.4 5.4 1.0 6.3 7.7 5.2 6.6 7.2 4.5 7.7 3.7 7.5 7.5 5.6 7.4 4.6 3.1 2.6 4.5 4.5 4.4 4.3 3.9 7.7 3.9 6.8 6.5 8.3 7.5 5.2 17.5 19.5 9.3 7.0 3.8 4.0 6.8 6.4 8.6 2.3 6.7 6.3 3.9 7.4 7.4 4.6 1.8 2.1 13.2 5.0 7.3 4.7 5.4 4.1 5.0 6.9 12.0 5.8 8.1 0.1 3.6 6.7 2.5 6.2 12.0 6.1 8.8 1.4 7.3 0.9 3.6 10.2 26.3 1.0 0.9 8.1 7.3 4.5 8.9 5.2 5.3 1.6 2.0 3.5 4.7 4.8 0.4 0.8 14.9 5.5 3.6 0.2 23.3 1.3 5.6 11.5 13.0 7.3 3.5 4.2 5.4 5.6 2.5 1.4 4.1 6.4 7.5 6.1 2.9 1.0 0.3 2.4 3.9 0.5 5.2 0.2 1.7 0.2 0.6 2.0 0.2 0.1 2.4 1.1 1.3 0.3 1.5 0.3 0.0 4.8 2.0 1.7 0.2 0.7 6.2 7.4 10.8 6.4 7.5 7.5 2.6 4.5 3.9 3.8 8.6 4.6 13.7 6.4 7.0 26.8 1.5 29.7 6.9 9.5 13.1 15.4 6.8 12.4 7.9 17.2 10.7 7.3 14.6 4.9 6.0 16.5 1.9 6.3 5.3 6.4 12.2 11.9 9.0 0.0 62.5 6.3 2.5 17.4 6.6 5.7 0.0 2.2 11.7 12.1 5.4 11.8 63.4 12.9 8.2 7.3 18.9 2.1 9.9 5.7 10.6 33.7 7.2 3.3 6.2 84.9 34.1 7.6 10.0 11.3 5.2 7.7 23.7 5.8 10.2 9.4 32.9 8.3 10.9 18.2 14.1 14.4 29.8 5.3 5.9 2.9 11.7 11.8 ACVR2B ActR-IIB ENSG00000114739 "Activin A receptor type 2B" Q13705 3 38453890-38493142 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Heterotaxy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Cancer enhanced" "Detected in all" "testis cancer: 5.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 20.9;NTERA-2: 25.9;SuSa: 14.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025115, HPA040384" Approved NA No "Cluster 54: Non-specific - Microtubule organization" "Cluster 12: NES - Nervous system development" "Cluster 52: Non-specific - Transcription" "CAB025115: , HPA040384: AB_2732484" "unprognostic (5.11e-2)" "unprognostic (1.54e-1)" "unprognostic (3.47e-1)" "unprognostic (8.73e-2)" "unprognostic (9.24e-2)" "unprognostic (2.21e-1)" "unprognostic (1.32e-2)" "unprognostic (1.25e-2)" "unprognostic (1.88e-1)" "unprognostic (1.53e-2)" "unprognostic (5.14e-2)" "unprognostic (1.30e-1)" "unprognostic (4.08e-3)" "unprognostic (1.64e-1)" "unprognostic (1.98e-1)" "unprognostic (1.83e-1)" "unprognostic (4.75e-1)" 1.1 2.8 3.2 0.6 3.2 0.2 1.7 5.2 2.8 1.9 1.0 1.5 0.9 1.7 1.7 0.7 1.9 0.6 1.4 2.6 3.0 1.8 2.2 1.3 0.7 2.6 3.2 2.9 2.5 3.3 2.0 2.5 2.6 1.3 1.1 6.5 1.7 1.3 6.0 0.7 1.1 0.9 2.3 1.0 1.5 2.5 2.9 4.1 1.6 2.8 0.6 1.4 1.4 3.6 1.1 1.8 20.9 1.8 0.8 0.5 11.2 0.4 0.7 0.4 0.9 3.1 1.4 0.1 1.6 0.5 0.6 1.3 8.1 1.3 1.1 3.2 5.2 5.6 3.5 4.6 1.0 4.0 2.0 0.8 1.2 0.6 2.3 1.3 1.4 8.0 9.4 1.8 0.4 1.7 6.9 2.5 25.9 1.1 0.9 2.2 7.0 1.4 1.3 2.6 4.9 8.5 0.6 3.2 3.0 14.7 1.7 5.2 1.2 0.7 3.3 0.5 1.8 5.0 7.3 1.2 0.7 3.2 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 3.2 3.2 5.2 2.8 2.6 3.0 2.6 3.2 2.6 2.3 2.9 3.6 7.0 6.4 6.1 9.4 0.7 4.0 4.6 2.1 4.0 23.0 5.2 5.0 15.0 2.8 3.6 0.0 22.9 8.5 1.3 3.1 0.0 3.6 11.3 8.7 7.0 7.5 7.2 0.4 12.6 3.8 7.6 3.8 2.6 5.3 1.3 17.9 7.9 8.7 2.6 21.9 17.0 4.1 0.0 2.2 6.4 15.8 11.8 2.4 7.2 5.6 0.7 7.6 0.0 15.1 17.2 3.2 5.3 7.9 1.4 5.2 4.8 3.1 7.1 25.4 0.0 9.7 7.7 11.4 17.9 1.8 4.0 6.2 2.6 7.4 4.4 3.9 ACVRL1 "ACVRLK1, ALK1, HHT, HHT2, ORW2" ENSG00000139567 "Activin A receptor like type 1" P37023 12 51906908-51923361 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" Angiogenesis "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lung: 96.3" "Cell type enhanced" "Detected in many" "Adipocytes: 107.3;Distal enterocytes: 182.7;Endothelial cells: 84.7;Fibroblasts: 56.0;Hepatic stellate cells: 60.3;Paneth cells: 74.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 19 "classical monocyte: 1.5;myeloid DC: 2.1" "Group enriched" "Detected in many" 19 "dendritic cells: 2.1;monocytes: 1.5" "Cell line enhanced" "Detected in some" "ASC diff: 61.4;ASC TERT1: 42.1;EFO-21: 61.0;HUVEC TERT2: 200.0;TIME: 161.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007041 Approved "Intracellular and membrane" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA007041: AB_1078097" "unprognostic (2.50e-1)" "unprognostic (4.83e-1)" "unprognostic (3.79e-2)" "unprognostic (3.61e-2)" "unprognostic (4.98e-1)" "unprognostic (4.06e-3)" "unprognostic (2.79e-1)" "unprognostic (1.35e-1)" "unprognostic (5.80e-2)" "unprognostic (5.10e-2)" "unprognostic (4.60e-2)" "unprognostic (4.64e-2)" "unprognostic (1.12e-3)" "unprognostic (1.39e-1)" "unprognostic (7.98e-3)" "unprognostic (2.79e-1)" "unprognostic (1.10e-1)" 49.2 12.1 17.1 20.1 14.5 0.6 38.4 15.5 14.9 35.9 10.5 39.2 10.2 28.1 4.3 11.4 32.7 14.3 38.5 13.3 14.6 29.8 3.3 96.3 15.1 17.8 16.7 4.8 12.0 23.6 6.2 83.8 18.7 17.7 28.4 0.7 11.8 13.3 18.2 18.5 28.5 16.2 14.0 29.2 19.1 1.7 22.0 4.6 29.2 15.7 6.1 25.1 25.6 15.0 0.0 0.7 0.4 0.0 61.4 42.1 0.1 3.0 5.6 0.1 0.3 0.3 0.4 0.1 61.0 24.0 0.2 0.0 0.0 0.0 0.1 0.1 2.1 1.4 0.0 0.0 9.0 0.0 1.3 16.8 0.1 0.4 0.0 0.0 200.0 0.0 0.2 0.1 1.1 0.5 0.0 0.6 0.3 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.1 0.9 0.0 0.0 0.1 0.4 0.0 4.1 161.2 0.0 0.4 0.7 0.0 0.0 0.1 0.2 0.3 0.9 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 17.1 14.5 15.5 14.9 13.3 14.6 17.8 16.7 18.7 14.0 22.0 15.0 107.3 3.2 7.9 0.0 0.6 5.2 0.3 0.0 0.6 0.4 1.0 1.3 4.0 0.0 1.3 0.0 0.0 0.6 0.3 182.7 0.0 4.0 0.0 1.4 19.9 84.7 5.4 0.0 0.1 1.4 36.9 56.0 0.5 0.7 0.0 0.0 60.3 0.1 12.0 0.0 0.0 26.4 0.0 30.9 12.4 1.2 11.8 7.8 5.4 25.3 9.9 2.0 0.0 1.0 0.1 0.0 74.7 3.4 0.1 0.6 4.5 0.0 2.8 0.4 39.5 32.9 18.2 0.1 0.8 0.6 5.4 2.6 1.2 0.6 49.3 1.0 ADK AK ENSG00000156110 "Adenosine kinase" P55263 10 74151202-74709963 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Purine salvage" "Kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 151.2" "Cell type enhanced" "Detected in all" "Excitatory neurons: 245.3;Inhibitory neurons: 287.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB032876, HPA038391, HPA038409, HPA075222" Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA 920000 "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Cytosol" "Plasma membrane" "CAB032876: AB_2242229, HPA038391: AB_2675990, HPA038409: AB_10675798, HPA075222: " "unprognostic (1.55e-3)" "unprognostic (1.09e-1)" "unprognostic (1.88e-1)" "unprognostic (2.62e-2)" "unprognostic (2.52e-2)" "prognostic unfavorable (1.93e-4)" "prognostic favorable (9.91e-4)" "unprognostic (2.64e-1)" "unprognostic (2.88e-1)" "unprognostic (1.55e-1)" "unprognostic (8.15e-3)" "unprognostic (2.51e-1)" "unprognostic (1.89e-3)" "unprognostic (2.03e-1)" "unprognostic (2.88e-2)" "unprognostic (4.97e-3)" "unprognostic (2.95e-2)" 23.9 15.5 13.0 16.9 18.7 28.6 27.4 13.5 17.7 17.5 11.6 17.9 16.9 10.8 16.5 47.3 16.5 11.4 27.2 13.9 15.2 35.8 151.2 24.4 22.8 14.0 15.0 8.3 18.8 44.2 14.9 26.6 16.5 14.9 19.5 16.1 20.0 16.0 41.5 33.9 12.4 14.8 14.2 15.0 12.1 15.5 14.1 27.0 38.2 47.1 34.5 24.5 24.7 15.8 177.3 37.4 37.2 50.5 37.1 54.7 88.2 140.8 105.4 103.8 114.5 114.0 172.6 86.3 34.2 57.7 51.3 151.1 44.1 150.1 167.0 59.1 51.3 55.6 59.8 122.8 41.7 87.6 22.5 51.1 95.5 77.4 191.7 79.0 91.2 38.7 41.8 28.4 78.8 101.7 102.5 129.0 9.9 80.0 276.3 100.6 63.7 69.4 117.1 92.7 29.5 33.8 63.6 239.7 49.5 34.7 159.7 69.3 82.8 34.3 67.0 93.2 123.0 40.5 48.3 98.1 65.0 127.6 22.1 2.3 34.2 4.1 12.9 65.5 29.9 103.7 28.2 24.1 83.1 155.0 21.3 19.2 11.1 20.7 80.4 57.6 55.7 36.3 13.0 18.7 13.5 17.7 13.9 15.2 14.0 15.0 16.5 14.2 14.1 15.8 9.8 83.3 75.8 136.5 84.2 94.2 73.5 102.0 105.9 16.3 26.2 26.0 67.8 38.6 72.4 31.3 56.3 136.7 25.9 11.0 92.0 83.2 80.7 40.6 18.8 14.9 10.8 27.7 245.3 67.5 139.5 27.0 23.0 55.6 21.5 9.7 17.2 130.1 39.3 11.8 287.7 12.1 44.7 25.2 50.0 26.9 16.8 33.7 48.0 198.6 44.1 14.1 11.3 140.8 165.4 62.7 10.4 12.0 39.1 92.1 5.0 64.5 33.5 25.0 6.6 20.4 26.0 17.4 14.3 96.7 97.0 107.3 32.7 17.0 20.5 66.3 ADPGK "ADP-GK, DKFZp434B195" ENSG00000159322 "ADP dependent glucokinase" Q9BRR6 15 72751369-72785846 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Glycolysis "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "monocytes: 140.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045194, HPA058525" Approved Approved Centrosome "Intracellular and membrane" NA NA 66000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 18: U-2197 - ECM organization" "Cluster 3: Monocytes - Immune response regulation" Centrosome "HPA045194: AB_10964638, HPA058525: AB_2683742" "unprognostic (5.96e-3)" "unprognostic (1.19e-1)" "unprognostic (2.22e-1)" "unprognostic (1.82e-1)" "unprognostic (1.29e-1)" "unprognostic (1.98e-1)" "unprognostic (1.45e-1)" "unprognostic (8.50e-2)" "unprognostic (2.27e-1)" "unprognostic (1.09e-1)" "unprognostic (1.21e-1)" "prognostic unfavorable (2.22e-4)" "prognostic unfavorable (4.52e-7)" "unprognostic (1.92e-1)" "unprognostic (6.05e-2)" "unprognostic (1.60e-1)" "unprognostic (2.07e-2)" 10.1 7.5 2.7 15.3 2.8 23.7 8.7 3.3 3.8 7.3 9.7 10.3 8.0 5.4 12.1 7.5 9.5 7.0 5.3 2.9 4.9 11.7 10.8 17.0 13.5 4.4 4.4 5.9 7.8 6.6 3.8 16.5 5.0 12.1 11.8 4.3 9.6 5.3 4.7 7.1 8.6 7.8 3.8 13.6 9.8 7.2 3.9 15.3 9.2 5.3 16.4 13.7 5.9 4.9 18.5 37.8 19.8 23.5 43.8 33.2 26.6 52.7 51.0 54.0 74.4 21.5 47.6 34.7 38.3 33.1 53.6 49.0 56.6 27.7 40.2 34.5 38.8 26.0 9.9 20.3 28.2 60.3 37.3 36.2 15.7 28.6 26.4 26.4 31.8 26.7 27.7 57.6 33.1 11.6 18.8 27.0 29.6 36.7 17.6 21.9 32.3 48.5 27.9 21.3 14.3 14.7 48.2 19.7 26.3 30.8 18.9 71.9 26.4 27.0 22.4 103.2 48.5 57.8 119.3 34.6 47.2 58.4 45.7 56.8 69.2 51.6 22.4 48.4 27.9 30.4 20.6 22.8 72.5 26.7 17.7 20.2 27.2 32.0 41.5 55.4 17.9 59.6 2.7 2.8 3.3 3.8 2.9 4.9 4.4 4.4 5.0 3.8 3.9 4.9 19.3 19.2 34.3 22.5 61.7 15.3 20.9 22.7 17.1 15.6 20.1 14.7 3.9 8.6 23.8 20.2 14.6 38.2 75.6 15.1 7.9 25.8 14.9 18.2 22.6 20.2 7.8 10.5 13.0 17.4 62.0 27.4 23.4 17.5 48.9 31.6 21.4 23.9 80.4 15.2 17.5 17.0 24.4 101.3 51.6 6.4 21.8 68.5 26.6 31.9 140.6 11.7 42.2 13.0 22.1 22.3 16.9 15.4 34.9 34.4 15.6 10.7 24.8 24.4 19.7 19.2 16.4 24.4 31.3 11.8 18.2 41.7 36.0 22.9 20.9 31.2 AGK "FLJ10842, MULK" ENSG00000006530 "Acylglycerol kinase" Q53H12 7 141551278-141655244 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Transferase" "Cardiomyopathy, Cataract, Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 43.4;Inhibitory neurons: 43.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "NK-cell: 97.3" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020959, HPA053471" Supported Supported Vesicles,Mitochondria "Intracellular and membrane" NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 25: RPMI-8226 - Immune response" "Cluster 63: NK-cells & T-cells - Immune response" Mitochondria Vesicles "HPA020959: AB_1854206, HPA053471: AB_2682164" "unprognostic (1.11e-1)" "unprognostic (1.43e-1)" "unprognostic (2.79e-1)" "unprognostic (1.28e-2)" "unprognostic (9.47e-3)" "unprognostic (5.43e-2)" "unprognostic (2.15e-2)" "unprognostic (3.68e-2)" "unprognostic (2.03e-1)" "unprognostic (3.43e-2)" "unprognostic (1.14e-1)" "unprognostic (6.24e-3)" "unprognostic (7.90e-2)" "unprognostic (9.29e-2)" "unprognostic (9.65e-2)" "unprognostic (3.30e-1)" "unprognostic (1.18e-1)" 10.1 14.7 9.4 8.5 10.9 5.6 11.9 8.3 12.8 11.5 10.2 11.8 5.9 11.7 14.5 12.2 12.2 7.8 30.4 11.1 10.8 15.7 14.1 11.6 12.1 8.0 8.8 11.3 10.1 21.5 13.7 10.0 9.0 12.8 13.1 12.7 13.7 11.4 8.6 9.6 12.0 15.4 8.2 16.6 12.2 6.6 10.0 14.0 12.7 10.0 14.7 10.8 11.5 9.0 23.7 25.6 26.7 21.8 21.2 29.4 16.2 23.5 29.3 44.5 50.9 24.7 18.3 26.3 24.0 26.8 40.5 18.7 41.6 32.8 51.0 33.8 32.7 26.1 10.7 18.7 34.1 15.6 12.5 29.9 26.9 36.3 33.1 19.8 34.1 32.3 36.3 36.9 25.3 24.6 47.3 9.1 25.6 19.9 32.4 29.2 4.2 80.1 33.1 20.8 23.3 29.6 24.6 29.7 27.1 26.1 16.3 20.2 19.5 18.9 14.1 23.8 38.1 29.5 31.9 14.4 30.7 9.1 50.4 0.4 7.1 1.2 22.1 13.9 15.3 10.8 17.3 26.0 16.2 6.5 12.8 23.5 1.2 97.3 8.2 6.3 18.9 15.7 9.4 10.9 8.3 12.8 11.1 10.8 8.0 8.8 9.0 8.2 10.0 9.0 8.4 0.0 6.0 22.5 11.4 3.1 5.6 7.9 5.2 11.8 5.5 5.1 18.1 2.8 6.6 12.9 8.4 15.7 15.8 3.0 9.8 6.6 9.9 7.4 9.0 7.5 0.0 11.8 43.4 6.9 8.2 7.7 10.7 6.6 8.2 9.9 4.2 4.1 7.0 15.2 43.0 3.9 12.2 5.1 4.9 12.0 6.8 5.6 7.2 26.2 12.4 11.2 27.8 38.7 37.9 6.1 2.1 10.5 22.1 2.9 2.4 8.2 7.6 17.4 0.0 6.2 8.0 6.2 4.9 11.3 2.7 9.2 15.0 14.2 5.6 3.8 AGL ENSG00000162688 "Amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase" P35573 1 99850361-99924023 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins" "Glycogen biosynthesis" "Glycosidase, Glycosyltransferase, Hydrolase, Multifunctional enzyme, Transferase" "Disease variant, Glycogen storage disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 5 "skeletal muscle: 257.6;tongue: 212.0" "Cell type enhanced" "Detected in all" "Muller glia cells: 160.5;Theca cells: 159.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028498, HPA054340" Approved Supported "Nucleoplasm,Nuclear bodies,Cytosol" NA NA 450000 "Cluster 15: NK-cells - Transcription" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 5: Muller glia cells - Visual perception" Nucleoplasm "Nuclear bodies, Cytosol" "HPA028498: AB_10600975, HPA054340: AB_2682455" "unprognostic (2.90e-1)" "unprognostic (5.34e-2)" "unprognostic (3.99e-3)" "unprognostic (2.18e-2)" "unprognostic (6.46e-3)" "unprognostic (5.13e-2)" "unprognostic (1.12e-1)" "unprognostic (1.92e-2)" "unprognostic (9.37e-3)" "unprognostic (1.11e-1)" "unprognostic (8.10e-3)" "unprognostic (7.61e-2)" "prognostic favorable (1.73e-10)" "unprognostic (6.38e-2)" "unprognostic (2.89e-1)" "unprognostic (1.15e-1)" "unprognostic (7.13e-2)" 11.9 6.7 4.1 7.1 4.9 6.1 9.1 6.9 5.6 6.1 6.0 10.0 8.8 7.3 7.6 16.4 5.4 5.2 22.8 3.7 5.1 13.3 42.8 5.9 7.3 4.7 5.6 5.9 4.3 17.6 4.5 11.7 4.4 13.8 10.6 23.3 7.7 9.6 257.6 5.3 7.1 9.7 4.9 8.0 7.7 4.7 4.8 7.9 10.5 212.0 8.5 8.9 5.0 5.6 20.4 5.9 7.0 11.4 11.0 10.4 23.4 6.3 9.2 5.5 9.8 22.3 6.8 26.4 11.7 10.8 4.9 11.3 40.5 12.4 10.2 14.2 12.9 15.5 18.9 12.4 7.3 13.7 8.9 12.8 7.9 7.5 6.2 7.5 8.5 9.2 26.3 2.0 5.5 6.2 16.3 4.3 10.9 8.9 7.7 0.0 2.3 1.3 16.3 26.7 17.2 12.1 18.2 17.3 9.9 12.8 12.6 9.0 9.4 6.6 9.3 8.9 6.3 7.3 6.1 30.5 11.7 3.6 3.5 0.0 0.4 1.4 1.5 0.6 1.4 1.0 1.1 1.0 0.9 1.0 1.1 1.1 0.5 2.4 0.3 0.8 1.3 0.8 4.1 4.9 6.9 5.6 3.7 5.1 4.7 5.6 4.4 4.9 4.8 5.6 12.8 22.4 26.8 96.6 28.5 10.6 18.1 24.6 18.2 34.6 18.8 18.0 119.6 18.6 25.8 16.5 54.2 107.9 18.8 23.2 23.5 13.7 1.2 18.8 23.6 13.9 16.8 15.6 45.6 12.9 20.3 28.5 31.1 18.6 10.8 45.0 14.6 111.0 17.9 52.2 56.0 15.8 12.2 19.1 8.8 2.5 10.2 13.5 16.0 23.4 14.1 160.5 21.6 36.2 34.4 17.7 14.3 21.4 20.4 13.0 15.2 19.2 26.0 46.9 6.6 41.4 18.4 8.7 11.9 40.0 9.2 29.1 25.7 159.1 23.5 20.1 AGPAT1 LPAAT-alpha ENSG00000204310 "1-acylglycerol-3-phosphate O-acyltransferase 1" Q99943 6 32168212-32178096 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Late spermatids: 91.7" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in all" "cerebral cortex: 47.1" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA048478, HPA073355" Approved Supported "Endoplasmic reticulum,Rods & Rings" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 72: Non-specific - Transcription" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 45: Enterocytes - Digestion" "Endoplasmic reticulum" "Rods & Rings" "HPA048478: AB_2680411, HPA073355: AB_2686596" "prognostic unfavorable (1.93e-4)" "unprognostic (9.35e-3)" "unprognostic (1.87e-3)" "prognostic unfavorable (5.21e-4)" "unprognostic (4.79e-2)" "unprognostic (7.05e-2)" "unprognostic (7.16e-3)" "unprognostic (1.55e-1)" "unprognostic (3.79e-1)" "unprognostic (4.24e-3)" "unprognostic (1.84e-3)" "unprognostic (1.77e-1)" "unprognostic (6.58e-2)" "unprognostic (1.97e-2)" "unprognostic (2.16e-1)" "unprognostic (9.92e-3)" "unprognostic (7.00e-2)" 46.6 60.3 3.0 5.9 7.2 6.6 42.6 2.5 47.1 58.2 2.9 61.3 28.2 64.3 42.9 33.9 56.5 18.9 66.9 4.0 25.5 61.6 60.2 44.2 10.9 3.8 9.5 67.2 37.5 9.3 53.8 15.9 4.4 53.2 20.1 12.5 34.1 0.0 67.7 35.1 53.0 1.5 2.5 39.8 58.4 79.3 3.3 18.4 54.1 33.5 12.5 58.2 42.7 4.7 0.0 0.4 51.2 0.3 127.5 85.2 49.4 0.0 0.0 0.0 0.0 104.5 0.0 0.0 46.1 128.0 36.4 13.4 108.5 39.4 0.0 0.4 83.6 0.0 0.0 111.7 0.0 0.0 101.5 51.0 47.6 0.0 46.0 105.9 31.6 86.7 78.5 66.0 109.2 28.8 0.4 26.8 0.0 0.1 18.0 0.6 0.0 0.5 32.8 0.0 0.0 0.1 51.3 16.1 70.4 51.6 63.4 0.0 25.9 0.0 20.3 0.0 0.2 45.9 41.1 18.0 64.3 0.1 0.3 3.4 5.6 12.4 7.6 8.2 7.4 5.3 5.0 8.6 9.3 5.0 4.3 6.4 9.4 8.7 5.8 11.6 7.2 6.9 3.0 7.2 2.5 47.1 4.0 25.5 3.8 9.5 4.4 2.5 3.3 4.7 32.1 16.0 18.6 11.1 14.3 9.1 14.0 20.6 16.5 26.1 26.2 21.6 4.0 14.3 12.0 36.8 12.5 35.2 24.5 28.7 5.9 17.9 63.9 14.1 24.9 21.3 29.4 12.0 13.8 14.3 29.9 19.6 16.3 11.4 12.7 22.7 27.1 31.2 24.7 32.0 17.7 24.3 18.3 22.3 20.6 91.7 13.4 24.9 8.8 11.2 13.0 38.5 21.6 10.1 14.8 17.0 22.3 21.4 16.9 10.2 73.6 29.4 12.9 17.9 0.0 18.3 22.9 44.8 22.1 9.5 3.7 15.3 13.8 21.5 20.8 12.1 AGPAT2 "BSCL, LPAAT-beta" ENSG00000169692 "1-acylglycerol-3-phosphate O-acyltransferase 2" O15120 9 136673143-136687457 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Congenital generalized lipodystrophy, Diabetes mellitus, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 369.3;liver: 445.0" "Cell type enhanced" "Detected in many" "Distal enterocytes: 688.9;Late spermatids: 387.3;Paneth cells: 670.7;Proximal enterocytes: 1298.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HDLM-2: 186.9" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA019544 Uncertain NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 85: Liver - Metabolism" "Cluster 44: HDLM-2 - Immune response" "Cluster 45: Enterocytes - Digestion" "HPA019544: AB_1844646" "unprognostic (3.20e-2)" "unprognostic (1.27e-1)" "unprognostic (5.01e-3)" "unprognostic (9.26e-2)" "unprognostic (1.50e-1)" "unprognostic (9.30e-3)" "unprognostic (5.06e-3)" "unprognostic (8.98e-2)" "unprognostic (1.42e-1)" "unprognostic (1.27e-1)" "unprognostic (2.17e-1)" "unprognostic (5.61e-2)" "unprognostic (2.60e-1)" "unprognostic (2.19e-2)" "unprognostic (1.92e-1)" "unprognostic (4.58e-2)" "unprognostic (2.93e-1)" 369.3 38.3 11.4 11.8 9.3 34.2 259.9 8.8 15.9 32.1 13.5 83.2 111.4 26.4 9.6 85.6 29.7 15.7 84.9 9.4 12.6 80.2 445.0 60.9 9.2 11.8 12.3 17.7 129.6 18.4 41.5 8.0 11.3 34.3 12.2 0.9 48.1 12.8 37.4 51.1 119.4 6.7 11.4 39.2 52.0 24.1 13.9 5.5 46.9 10.0 5.3 35.5 36.6 9.6 55.0 75.2 8.9 41.4 63.3 19.8 37.3 35.5 28.5 24.1 18.5 86.0 105.7 17.8 77.8 21.0 38.6 145.1 12.7 22.2 2.8 186.9 57.3 26.5 30.3 19.2 42.6 28.1 62.1 19.0 30.9 20.9 11.0 20.9 12.5 23.6 32.7 2.9 10.4 98.5 1.9 87.4 22.5 101.0 135.0 41.0 31.3 100.3 28.5 33.9 19.5 31.4 45.8 47.6 60.3 6.8 30.6 109.3 24.7 31.5 32.1 10.4 23.0 4.4 0.4 11.8 0.4 59.7 32.1 20.1 88.8 111.8 6.8 83.5 6.5 12.8 5.8 7.9 47.8 22.7 4.6 5.5 61.1 7.2 75.7 65.6 8.1 35.2 11.4 9.3 8.8 15.9 9.4 12.6 11.8 12.3 11.3 11.4 13.9 9.6 25.9 16.0 64.4 0.7 20.2 45.2 60.0 64.0 22.8 3.5 23.4 22.4 39.6 87.2 45.3 73.5 0.0 7.3 30.8 688.9 54.8 155.2 136.4 50.4 17.4 27.9 35.8 8.0 1.9 219.5 37.1 30.1 81.6 63.8 13.4 31.4 31.1 228.0 131.2 40.4 2.6 197.3 126.1 53.4 57.4 387.3 26.8 57.6 136.9 4.7 48.8 14.6 23.7 0.0 0.3 169.5 670.7 20.3 13.4 93.5 1298.3 41.9 46.3 3.8 46.0 15.3 29.8 1.8 27.2 47.5 81.3 6.8 26.6 16.4 207.7 196.2 AGPAT3 "LPAAT-gamma, LPAAT3" ENSG00000160216 "1-acylglycerol-3-phosphate O-acyltransferase 3" Q9NRZ7 21 43865223-43987592 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 183.5;Early spermatids: 219.0;Late spermatids: 219.3;Rod photoreceptor cells: 184.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "non-classical monocyte: 9.6" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 54: Non-specific - Microtubule organization" "Cluster 44: HDLM-2 - Immune response" "Cluster 46: Photoreceptor cells - Phototransduction" "unprognostic (2.36e-2)" "prognostic unfavorable (8.31e-4)" "unprognostic (5.50e-2)" "unprognostic (4.56e-3)" "unprognostic (4.70e-2)" "unprognostic (8.55e-2)" "unprognostic (4.88e-2)" "unprognostic (9.72e-3)" "unprognostic (2.14e-1)" "unprognostic (3.54e-2)" "unprognostic (1.65e-1)" "unprognostic (2.84e-1)" "prognostic favorable (2.29e-4)" "unprognostic (1.50e-2)" "unprognostic (8.91e-2)" "unprognostic (1.80e-1)" "unprognostic (4.60e-2)" 20.9 20.9 41.5 19.2 47.1 11.1 15.1 42.3 34.9 11.7 14.8 22.0 44.7 10.3 12.6 25.7 12.3 13.8 27.8 38.4 36.0 53.4 53.2 18.8 16.4 52.1 41.8 10.4 21.3 24.6 14.7 12.2 39.2 13.8 11.9 61.9 30.5 11.6 62.3 24.3 52.4 8.7 47.8 19.1 18.0 26.4 48.1 15.4 21.4 50.2 10.3 15.4 15.0 48.2 73.0 40.0 10.0 27.5 17.8 20.4 7.7 32.6 40.6 40.8 25.1 40.3 51.4 24.5 24.3 39.3 38.4 27.8 17.3 36.5 11.8 117.2 45.8 10.8 24.4 54.8 33.6 39.6 23.5 25.1 30.4 36.1 15.0 35.1 31.2 8.0 61.4 39.1 15.0 31.2 0.4 22.9 4.7 28.2 28.5 40.6 11.3 65.9 29.7 70.2 34.0 24.7 40.0 45.0 29.9 3.9 31.3 42.9 46.6 25.9 0.3 39.1 34.0 31.0 50.3 15.3 33.3 78.3 23.9 0.0 3.3 2.2 1.1 7.4 1.2 0.9 1.6 1.7 3.8 1.1 1.3 1.5 0.9 0.6 9.6 0.9 3.0 1.8 41.5 47.1 42.3 34.9 38.4 36.0 52.1 41.8 39.2 47.8 48.1 48.2 17.0 12.8 25.4 33.0 7.0 8.0 9.3 14.5 7.4 40.3 19.8 12.3 33.4 25.8 21.0 25.8 183.5 15.9 10.8 45.1 9.8 25.7 219.0 17.7 16.6 16.3 13.8 12.8 34.3 29.5 1.1 10.4 19.9 18.5 5.1 24.6 15.4 68.7 19.0 65.6 37.9 19.7 12.2 32.6 27.3 219.3 7.8 25.7 1.8 17.8 38.5 34.1 9.2 19.1 28.7 26.8 18.8 5.7 11.8 18.6 60.5 52.6 31.0 184.0 6.6 14.9 24.4 7.0 2.4 17.4 11.1 12.0 14.4 22.0 22.5 15.7 AGPAT4 "dJ473J16.2, LPAAT-delta" ENSG00000026652 "1-acylglycerol-3-phosphate O-acyltransferase 4" Q9NRZ5 6 161129967-161274061 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 4 "brain: 51.3" "Cell type enriched" "Detected in many" 4 "Oligodendrocytes: 407.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "AF22: 25.5;HEL: 19.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA053287, HPA060525" Approved Approved "Nucleoli,Golgi apparatus,Vesicles" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 70: Brain - Nervous system development" "Cluster 12: NES - Nervous system development" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Golgi apparatus" "Nucleoli, Vesicles" "HPA053287: AB_2682101, HPA060525: AB_2684306" "unprognostic (5.69e-2)" "prognostic unfavorable (1.45e-4)" "unprognostic (1.73e-1)" "unprognostic (3.43e-2)" "unprognostic (4.14e-2)" "unprognostic (6.67e-3)" "unprognostic (1.94e-4)" "unprognostic (1.05e-1)" "unprognostic (3.42e-2)" "unprognostic (2.77e-2)" "unprognostic (1.76e-3)" "unprognostic (1.67e-1)" "prognostic unfavorable (4.08e-4)" "unprognostic (1.82e-2)" "unprognostic (8.87e-2)" "unprognostic (3.63e-4)" "unprognostic (5.51e-2)" 4.8 2.1 14.7 1.8 30.5 5.2 4.5 24.6 22.5 7.2 5.6 6.4 1.2 7.8 2.2 3.7 6.1 4.2 2.6 14.9 22.7 6.0 0.8 6.7 0.9 47.1 26.3 7.4 2.1 0.3 11.4 8.7 34.3 3.6 2.1 2.2 2.7 2.4 1.0 2.3 2.6 4.7 25.5 4.6 2.3 2.8 28.6 1.3 4.1 1.0 1.0 3.0 5.0 51.3 0.5 1.0 25.5 5.1 4.7 9.5 1.1 0.9 0.3 1.9 3.2 1.5 4.6 0.7 1.8 4.2 11.8 0.5 4.8 4.0 1.8 2.9 8.1 19.4 4.9 0.1 3.7 0.2 2.8 11.4 1.9 5.0 2.7 9.1 6.1 3.1 9.8 8.9 2.4 0.0 1.4 2.2 6.2 0.0 9.7 0.0 1.1 0.5 5.6 0.4 14.8 5.6 4.0 2.1 1.1 9.9 1.1 1.2 6.8 2.6 3.3 1.8 4.4 0.7 1.0 0.0 9.9 1.0 1.6 0.0 1.8 0.0 3.4 1.5 1.1 0.2 1.6 2.1 1.0 0.5 0.8 1.2 0.3 2.9 1.3 0.8 1.7 1.3 14.7 30.5 24.6 22.5 14.9 22.7 47.1 26.3 34.3 25.5 28.6 51.3 12.0 3.2 5.5 7.5 4.5 3.2 5.5 9.7 6.2 2.4 3.5 2.7 5.6 5.7 6.9 5.5 0.0 20.3 31.1 6.1 0.0 5.2 52.1 23.8 12.5 13.5 1.8 31.5 87.9 8.2 12.0 17.8 4.6 5.1 11.4 20.6 10.4 0.2 18.2 0.0 95.8 0.7 10.2 7.2 16.4 72.8 5.9 17.0 3.6 23.4 9.4 4.0 9.2 56.3 407.6 5.5 18.7 8.6 15.7 1.3 0.0 0.6 21.4 1.2 19.7 5.3 6.9 4.9 2.8 1.1 2.6 22.2 14.1 3.7 1.4 3.6 AGPAT5 "FLJ11210, LPAAT-e, LPAAT-epsilon" ENSG00000155189 "1-acylglycerol-3-phosphate O-acyltransferase 5" Q9NUQ2 8 6708642-6761503 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Glandular and luminal cells: 83.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA010644, HPA010950, HPA011646" Approved Supported Mitochondria NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 43: Testis - Unknown function" "Cluster 36: HEL - Hemostasis" "Cluster 44: Endometrium - Transcription" Mitochondria "HPA010644: AB_1844647, HPA010950: AB_1844648, HPA011646: " "unprognostic (1.05e-3)" "unprognostic (4.69e-1)" "prognostic favorable (8.82e-4)" "unprognostic (2.05e-2)" "unprognostic (2.99e-1)" "unprognostic (1.44e-2)" "prognostic unfavorable (4.57e-4)" "unprognostic (4.92e-1)" "unprognostic (1.82e-1)" "unprognostic (2.98e-2)" "unprognostic (6.33e-2)" "unprognostic (2.91e-1)" "unprognostic (6.62e-2)" "unprognostic (2.83e-1)" "unprognostic (3.60e-1)" "unprognostic (1.53e-2)" "unprognostic (5.09e-3)" 5.4 11.8 6.7 2.9 6.8 2.3 4.9 7.2 8.3 6.5 6.1 8.0 3.1 6.6 7.9 8.5 7.4 1.8 3.4 6.6 7.4 7.2 10.0 4.5 4.1 7.8 7.4 5.8 6.4 3.3 10.3 4.1 7.6 6.0 4.2 5.2 5.0 5.6 11.3 3.5 6.7 2.9 7.6 4.8 6.9 22.5 7.1 4.7 4.0 2.7 3.7 4.7 5.8 8.7 8.5 7.0 15.3 6.8 3.4 5.2 9.4 4.3 4.6 7.9 7.0 4.6 7.3 21.8 3.2 3.3 10.8 11.0 9.5 9.5 11.2 4.6 6.6 27.4 7.0 10.5 9.1 12.4 10.0 7.6 10.0 6.7 9.8 8.2 13.6 9.5 19.9 10.7 11.4 6.3 23.5 20.1 20.4 13.6 5.8 15.0 15.0 8.2 7.9 13.1 24.4 14.8 4.1 7.9 9.4 8.1 3.6 20.5 5.5 10.8 5.4 4.4 12.4 4.0 12.8 11.3 7.3 13.8 12.9 1.8 1.9 1.2 0.7 2.4 1.6 4.4 1.3 1.4 1.2 5.1 0.9 1.1 0.2 2.7 2.2 4.4 1.2 1.4 6.7 6.8 7.2 8.3 6.6 7.4 7.8 7.4 7.6 7.6 7.1 8.7 15.7 3.2 4.4 58.8 46.5 9.1 18.8 14.2 19.4 7.8 14.2 10.5 5.8 11.5 9.0 7.3 2.1 9.4 23.5 17.4 3.9 11.2 40.0 30.0 27.9 22.3 22.1 50.0 45.0 10.0 14.2 10.4 27.0 83.6 18.9 10.6 10.4 41.9 12.2 6.7 46.8 10.1 14.2 16.0 4.6 34.7 15.8 12.6 7.2 33.7 7.5 42.3 6.2 56.8 60.2 10.2 16.0 15.4 22.3 30.4 9.8 22.5 14.6 9.8 6.6 14.0 24.7 26.2 10.9 30.9 10.4 18.5 17.4 15.0 25.2 11.9 AGPS "ADAP-S, ADAS, ADHAPS, ADPS, ALDHPSY" ENSG00000018510 "Alkylglycerone phosphate synthase" O00116 2 177392746-177567024 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism" Transferase "Cataract, Disease variant, Dwarfism, Rhizomelic chondrodysplasia punctata" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 262.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030209, HPA030210, HPA030211" Supported Supported Peroxisomes "Intracellular and membrane" NA NA 69000 "Cluster 26: Non-specific - Mitochondria" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 23: Spermatids - Flagellum & Golgi organization" Peroxisomes "HPA030209: AB_10600634, HPA030210: AB_10600202, HPA030211: AB_10602195" "unprognostic (7.10e-2)" "unprognostic (1.20e-2)" "unprognostic (1.76e-3)" "unprognostic (3.79e-2)" "unprognostic (8.34e-2)" "unprognostic (3.78e-2)" "prognostic unfavorable (8.62e-6)" "unprognostic (1.23e-2)" "unprognostic (7.23e-2)" "unprognostic (5.41e-2)" "prognostic unfavorable (8.35e-4)" "unprognostic (7.74e-2)" "prognostic favorable (9.45e-4)" "unprognostic (7.18e-2)" "unprognostic (3.46e-1)" "unprognostic (4.94e-3)" "unprognostic (1.92e-2)" 14.3 9.2 4.4 15.6 6.9 19.6 13.9 7.1 6.9 14.3 4.6 20.1 11.1 14.6 6.5 12.7 9.8 11.3 10.4 4.7 6.6 18.1 19.3 13.7 11.9 8.9 7.0 7.8 11.4 18.5 3.4 13.2 8.2 7.0 21.9 6.4 8.3 8.8 11.7 4.5 13.1 21.1 7.8 8.7 9.9 16.3 6.3 16.1 12.6 12.6 12.8 14.6 5.2 11.9 43.1 36.3 23.3 19.0 32.2 33.2 33.3 29.6 21.9 34.5 34.8 70.6 34.0 58.5 59.5 45.0 46.3 47.5 64.4 45.1 47.8 51.4 16.7 77.6 56.5 75.8 31.9 82.3 63.5 28.6 28.7 58.6 44.6 33.3 75.3 42.1 44.9 26.3 45.7 0.1 59.9 22.4 33.3 42.7 30.9 47.0 65.1 32.7 60.0 65.0 22.0 31.3 66.2 5.8 43.0 58.1 0.4 35.4 70.0 29.4 61.9 26.8 64.2 28.7 59.0 23.6 29.4 43.1 11.8 2.6 3.3 5.8 1.9 4.0 2.9 1.7 3.0 2.4 3.6 1.1 2.7 1.6 1.5 2.8 3.6 0.1 4.3 2.2 4.4 6.9 7.1 6.9 4.7 6.6 8.9 7.0 8.2 7.8 6.3 11.9 20.2 16.0 13.1 29.4 10.7 10.8 6.5 15.5 12.0 11.5 19.2 6.7 20.0 20.0 13.0 14.7 2.1 14.1 15.5 25.6 13.7 20.9 262.2 25.2 17.2 14.0 19.8 20.8 53.0 23.2 20.6 23.0 18.8 25.4 64.1 16.6 11.7 31.0 31.8 15.2 61.7 30.4 16.2 30.0 31.8 41.4 14.6 28.7 14.2 56.2 36.0 12.0 21.6 45.8 83.8 23.9 17.4 13.9 14.1 3.8 15.3 46.5 21.6 7.6 6.6 16.8 16.4 41.7 22.2 16.2 9.8 7.0 19.0 22.7 26.0 6.1 AGXT "AGT, AGT1, AGXT1, PH1, SPAT, SPT" ENSG00000172482 "Alanine--glyoxylate and serine--pyruvate aminotransferase" P21549 2 240868824-240880502 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Aminotransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 315 "liver: 2199.2" "Cell type enriched" "Detected in some" 5 "Hepatocytes: 2037.9" "Cancer enriched" "Detected in some" 425 "liver cancer: 253.1" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 4 "Hep G2: 5.2" "Not detected" "Not detected" "Not detected" "Not detected" "HPA035370, HPA035371" Enhanced Supported Vesicles NA NA 4700000 "Cluster 62: Liver - Hemostasis" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 2: Hepatocytes - Metabolism" Vesicles "HPA035370: AB_10673218, HPA035371: AB_2674593" "unprognostic (3.14e-2)" "unprognostic (2.58e-1)" "unprognostic (3.37e-4)" "unprognostic (1.04e-1)" "unprognostic (1.23e-2)" "unprognostic (9.56e-2)" "prognostic favorable (5.92e-5)" "unprognostic (8.28e-2)" "unprognostic (2.77e-1)" "unprognostic (5.39e-2)" "unprognostic (1.55e-1)" "unprognostic (7.57e-3)" "unprognostic (2.54e-1)" "unprognostic (9.22e-2)" "unprognostic (1.37e-1)" "unprognostic (3.26e-2)" 0.5 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 6.9 2199.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.1 0.2 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 2.2 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 5.2 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.2 0.0 0.3 1.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 44.3 0.1 7.3 0.0 0.7 0.0 7.6 23.5 0.1 0.1 0.2 0.0 2.8 9.0 128.4 0.0 1.7 26.7 0.4 0.0 0.4 0.0 0.0 52.5 2037.9 0.2 0.0 0.0 8.1 4.1 53.5 0.0 1.6 0.9 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 12.8 0.4 0.0 0.8 1.9 343.9 0.1 0.0 0.0 2.7 0.1 0.1 0.0 0.0 0.0 1.9 5.2 0.1 1.5 0.4 AGXT2 AGT2 ENSG00000113492 "Alanine--glyoxylate aminotransferase 2" Q9BYV1 5 34998101-35048135 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Aminotransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 44 "kidney: 207.9;liver: 123.5" "Group enriched" "Detected in some" 5 "Hepatocytes: 105.9;Proximal tubular cells: 359.5" "Group enriched" "Detected in some" 112 "liver cancer: 9.2;renal cancer: 12.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA037382 Enhanced NA NA 13000 "Cluster 81: Kidney & Liver - Metabolism" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA037382: AB_10670851" "unprognostic (2.61e-1)" "unprognostic (1.40e-2)" "prognostic favorable (7.47e-4)" "unprognostic (8.24e-2)" "unprognostic (1.28e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.4 0.1 0.0 0.0 0.0 0.8 0.0 0.0 0.0 207.9 123.5 0.0 0.0 0.0 0.2 0.0 0.0 0.3 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.7 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 2.8 0.0 9.2 0.0 0.0 0.0 0.0 45.0 0.0 0.0 0.0 0.1 0.1 0.0 2.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 105.9 0.0 0.0 0.2 0.6 0.0 2.4 0.0 0.0 0.3 1.6 0.0 0.0 0.0 0.0 0.0 0.5 0.2 0.0 1.2 0.4 0.0 0.0 6.7 359.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.1 0.0 0.3 0.0 AK1 ENSG00000106992 "Adenylate kinase 1" P00568 9 127866486-127877675 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Transferase" "Disease variant, Hereditary hemolytic anemia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 1346.2;tongue: 783.3" "Cell type enhanced" "Detected in all" "Early spermatids: 281.3;Late spermatids: 1031.8;Muller glia cells: 287.6;Peritubular cells: 386.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "U-2197: 163.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006456, CAB009893" Enhanced Supported Cytosol NA NA 24000000 "Cluster 33: Neutrophils - Chromatin organization" "Cluster 80: Striated muscle - Unknown function" "Cluster 18: U-2197 - ECM organization" "Cluster 31: Spermatids - Spermatogenesis" Cytosol "CAB009893: AB_2225151, HPA006456: AB_1078116" "unprognostic (6.07e-3)" "unprognostic (1.44e-2)" "unprognostic (2.36e-2)" "unprognostic (1.03e-1)" "unprognostic (3.44e-1)" "unprognostic (3.09e-1)" "unprognostic (1.52e-2)" "unprognostic (3.12e-2)" "unprognostic (2.19e-1)" "unprognostic (5.74e-2)" "unprognostic (6.65e-3)" "unprognostic (2.07e-1)" "unprognostic (1.81e-2)" "prognostic favorable (7.31e-4)" "unprognostic (2.62e-1)" "unprognostic (8.40e-3)" "unprognostic (6.99e-3)" 28.5 34.5 81.3 11.5 79.2 28.4 17.0 87.9 95.1 37.5 145.8 33.8 17.9 14.3 28.5 32.0 342.2 22.5 270.0 79.5 88.5 31.4 26.5 74.6 5.0 97.4 99.8 45.0 14.9 47.0 33.8 7.6 99.0 17.1 39.5 29.0 33.1 35.9 1346.2 14.2 12.1 21.9 105.0 20.8 23.9 63.1 89.4 3.9 34.8 783.3 12.6 19.7 19.4 97.2 56.7 23.6 30.1 40.4 71.2 142.9 27.4 38.3 38.2 66.7 40.4 18.0 34.9 1.5 40.8 79.4 44.1 79.2 0.3 43.1 26.6 9.0 26.1 8.3 65.2 31.6 40.1 0.0 1.0 110.9 81.8 49.9 35.5 36.8 90.3 0.8 33.7 2.3 76.7 53.5 0.1 1.1 10.6 139.7 74.2 1.3 30.0 12.6 44.8 4.1 48.3 30.4 101.0 57.4 29.8 15.3 45.8 33.3 75.9 45.9 18.8 163.8 37.3 3.5 0.6 0.2 57.7 0.3 32.4 0.2 0.0 0.1 0.3 0.0 0.2 0.0 0.1 0.2 0.0 0.2 0.0 0.2 0.5 0.2 0.1 0.9 0.0 0.3 81.3 79.2 87.9 95.1 79.5 88.5 97.4 99.8 99.0 105.0 89.4 97.2 12.8 41.7 148.1 25.8 2.6 26.4 17.2 84.5 6.2 54.6 11.5 7.9 49.7 28.6 79.4 7.3 16.7 7.5 5.7 210.1 17.6 116.7 281.3 7.3 8.0 39.8 106.3 97.0 11.1 60.9 46.8 37.3 46.4 4.8 1.3 2.7 49.2 77.3 59.3 48.8 12.0 62.7 120.1 3.7 22.3 1031.8 226.5 7.9 83.6 2.8 2.3 287.6 10.3 4.5 9.7 57.2 132.7 386.3 4.2 14.4 22.8 8.2 186.5 69.5 26.3 107.2 56.4 20.2 16.7 33.6 28.4 13.5 7.1 83.4 65.5 25.3 AK2 ENSG00000004455 "Adenylate kinase 2" P54819 1 33007940-33080996 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Transferase" "Disease variant, SCID" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Proximal tubular cells: 440.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018479, CAB079913" Approved Approved Mitochondria NA NA 1100000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 8: Non-specific - Mitochondria" "Cluster 32: U-937 - Innate immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Mitochondria "CAB079913: AB_2546087, HPA018479: AB_1844676" "prognostic favorable (4.37e-4)" "unprognostic (3.25e-2)" "unprognostic (2.80e-2)" "prognostic unfavorable (8.65e-4)" "unprognostic (3.16e-2)" "unprognostic (8.21e-2)" "prognostic unfavorable (9.32e-4)" "unprognostic (7.86e-3)" "unprognostic (1.85e-2)" "unprognostic (1.28e-1)" "prognostic unfavorable (6.40e-4)" "unprognostic (4.95e-2)" "unprognostic (8.33e-3)" "unprognostic (9.56e-3)" "unprognostic (2.71e-1)" "unprognostic (1.40e-1)" "unprognostic (5.40e-3)" 85.3 88.6 39.9 76.9 45.0 74.3 80.4 44.1 49.0 79.6 49.8 117.2 140.0 58.6 52.1 108.5 65.3 49.0 114.1 38.8 43.8 181.6 172.9 59.3 73.3 48.5 42.8 59.9 78.9 123.6 49.4 68.4 50.4 63.2 114.0 51.0 81.1 55.5 154.2 74.4 139.4 68.1 44.0 57.2 92.7 54.8 44.3 85.9 86.6 122.9 113.4 84.2 76.9 49.3 339.1 153.4 131.6 149.7 94.9 116.6 132.8 185.0 143.5 267.7 280.2 283.2 311.9 602.1 218.4 139.8 204.2 235.4 312.5 327.0 276.6 261.6 229.3 396.2 270.0 219.9 218.2 712.5 222.2 118.1 238.2 232.7 471.2 163.3 190.2 245.7 436.9 230.4 165.0 174.2 273.0 392.8 181.2 337.4 222.4 314.7 222.2 415.6 286.2 205.1 190.8 114.8 205.4 235.0 584.8 151.4 194.5 517.2 138.9 165.5 194.3 259.4 357.5 238.0 324.7 565.7 232.4 664.6 195.5 49.2 158.8 198.0 77.1 145.5 81.8 122.3 72.7 74.0 195.8 105.8 72.9 67.9 42.1 115.3 130.4 154.2 96.8 188.1 39.9 45.0 44.1 49.0 38.8 43.8 48.5 42.8 50.4 44.0 44.3 49.3 60.5 51.3 79.0 19.6 44.0 125.2 101.4 228.1 63.7 21.1 66.5 72.6 106.9 71.4 142.8 112.2 83.4 158.0 37.0 109.6 256.3 120.2 108.3 50.0 42.1 70.7 50.4 50.9 16.2 123.7 164.6 58.0 66.3 47.0 40.0 38.8 41.4 135.5 96.1 8.4 19.7 84.7 89.5 44.8 60.1 42.8 46.9 48.4 87.2 12.2 67.3 22.1 48.4 14.1 22.0 110.5 67.2 44.0 55.7 109.0 236.9 440.0 67.0 41.8 52.6 34.1 108.4 91.0 31.6 88.6 122.7 216.6 40.7 72.2 122.6 120.5 AK3 "AK3L1, AK6, AKL3L1" ENSG00000147853 "Adenylate kinase 3" Q9UIJ7 9 4709556-4742043 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 242.8" "Cell type enhanced" "Detected in all" "Hepatocytes: 305.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HDLM-2: 485.4;HEL: 273.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA063324 Enhanced Supported Mitochondria NA NA 31000 "Cluster 15: NK-cells - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 44: HDLM-2 - Immune response" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "HPA063324: AB_2684985" "unprognostic (1.30e-2)" "unprognostic (2.25e-1)" "unprognostic (1.28e-1)" "unprognostic (1.06e-1)" "unprognostic (6.55e-2)" "unprognostic (1.02e-1)" "unprognostic (2.21e-3)" "unprognostic (6.44e-2)" "unprognostic (2.81e-2)" "unprognostic (9.81e-3)" "unprognostic (1.90e-1)" "unprognostic (2.76e-2)" "prognostic favorable (6.07e-9)" "unprognostic (1.24e-1)" "unprognostic (1.40e-1)" "unprognostic (1.39e-1)" "unprognostic (1.55e-3)" 75.5 62.9 30.1 23.7 36.9 20.1 39.7 33.5 34.9 41.0 56.2 67.4 68.3 41.9 31.2 61.2 34.4 35.9 100.6 27.0 40.6 101.4 199.9 34.9 29.6 32.8 38.1 47.8 38.9 66.8 22.2 35.1 33.7 49.2 59.6 16.8 38.7 42.6 242.8 47.4 62.5 41.7 33.5 33.0 69.5 11.2 37.9 35.1 49.9 159.6 34.4 48.7 39.7 36.5 44.1 30.7 55.5 22.6 75.3 55.5 4.9 60.4 116.1 30.4 45.5 5.7 43.6 39.5 20.4 63.5 16.6 29.3 40.8 48.0 51.2 485.4 37.1 273.3 56.1 91.3 58.5 28.7 14.1 87.9 41.4 26.4 36.0 70.4 91.2 38.2 22.1 49.6 91.8 22.5 27.5 65.6 53.3 77.1 15.4 38.2 21.1 19.2 82.1 55.7 98.3 63.6 65.7 18.5 35.1 53.7 26.5 53.2 65.9 25.7 28.8 70.1 43.6 15.5 10.5 50.3 46.9 19.9 18.9 13.3 10.2 32.2 27.6 8.1 25.5 12.1 21.6 25.7 19.6 12.3 28.4 29.2 2.8 27.4 6.5 26.3 31.8 21.1 30.1 36.9 33.5 34.9 27.0 40.6 32.8 38.1 33.7 33.5 37.9 36.5 58.3 57.7 80.3 78.0 34.0 74.2 76.4 87.4 84.2 10.7 58.8 28.3 182.9 68.6 71.0 66.2 22.9 95.5 34.6 129.9 258.2 84.8 3.7 40.7 30.6 65.7 109.6 68.1 23.4 69.6 17.0 83.4 87.1 37.8 46.2 75.8 79.2 305.6 47.5 15.2 55.8 104.2 73.2 46.9 41.4 4.5 108.7 34.7 74.7 22.5 40.9 28.2 33.0 44.7 87.0 67.3 78.7 149.7 62.8 166.7 111.8 183.5 52.8 11.0 105.2 76.0 60.8 6.4 14.1 152.5 104.4 214.0 36.4 68.5 145.5 151.6 AK4 "AK3, AK3L1" ENSG00000162433 "Adenylate kinase 4" P27144 1 65147549-65232145 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "kidney: 183.5;liver: 104.0" "Cell type enhanced" "Detected in many" "Hepatocytes: 242.6;Proximal tubular cells: 595.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "classical monocyte: 3.1;myeloid DC: 2.7" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "Hep G2: 208.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA042753, HPA049461" Enhanced Supported Mitochondria "Intracellular and membrane" NA Yes 39000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 81: Kidney & Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Mitochondria "HPA042753: AB_2678146, HPA049461: AB_2680776" "unprognostic (3.73e-2)" "prognostic unfavorable (4.17e-4)" "unprognostic (2.25e-1)" "unprognostic (3.05e-3)" "unprognostic (1.48e-2)" "prognostic unfavorable (8.83e-4)" "unprognostic (1.16e-3)" "unprognostic (3.89e-2)" "unprognostic (4.03e-1)" "unprognostic (5.39e-2)" "prognostic unfavorable (4.34e-5)" "unprognostic (6.71e-2)" "prognostic unfavorable (4.36e-4)" "prognostic unfavorable (4.87e-4)" "unprognostic (2.69e-1)" "unprognostic (7.07e-2)" "unprognostic (7.57e-2)" 24.7 1.9 19.5 6.6 21.0 4.9 26.6 17.8 20.8 6.1 17.5 19.7 4.3 7.0 4.2 23.4 7.6 13.7 51.7 21.4 21.2 183.5 104.0 2.8 1.6 19.0 22.8 4.6 1.2 18.3 4.7 8.3 22.8 16.2 14.0 21.9 9.6 12.7 1.7 27.4 6.6 21.4 18.5 1.2 15.0 11.3 22.7 5.7 2.5 38.8 3.3 19.1 11.8 21.1 73.2 5.0 5.6 23.9 51.6 48.7 12.0 12.1 15.0 25.6 70.8 108.1 8.6 39.1 31.0 19.0 32.1 46.1 18.8 89.9 101.9 33.0 21.5 37.9 21.9 208.6 2.5 29.9 4.6 27.2 49.6 25.1 73.0 42.2 0.9 12.2 48.0 0.6 39.6 31.2 1.1 1.3 24.6 1.0 42.5 0.2 41.0 7.1 37.8 3.2 20.5 15.4 21.6 1.5 16.7 25.8 29.7 12.9 4.2 42.4 36.2 3.3 20.9 39.5 18.8 2.1 68.7 10.9 2.5 0.9 3.1 0.0 0.1 0.6 0.2 0.2 0.1 0.2 2.7 0.1 0.1 0.1 0.4 0.3 0.1 0.4 0.0 0.8 19.5 21.0 17.8 20.8 21.4 21.2 19.0 22.8 22.8 18.5 22.7 21.1 11.2 0.0 0.5 51.2 4.7 49.7 23.6 44.2 63.7 24.5 48.9 44.7 105.7 52.9 14.3 31.3 2.1 2.2 0.6 15.8 56.7 18.6 3.4 30.1 8.2 19.6 5.4 13.9 17.1 12.1 21.1 11.4 27.5 52.2 0.0 36.4 11.7 242.6 3.3 16.8 7.7 8.7 24.4 7.8 9.2 5.8 4.1 6.9 24.9 3.7 5.7 32.7 0.0 9.5 2.5 31.9 4.3 9.4 0.4 38.7 18.8 595.5 12.3 6.5 6.6 5.6 18.8 1.8 9.5 43.1 74.3 4.9 3.6 0.7 23.1 20.4 AK5 ENSG00000154027 "Adenylate kinase 5" Q9Y6K8 1 77282019-77559966 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "brain: 121.0" "Cell type enhanced" "Detected in many" "Early spermatids: 150.5;Excitatory neurons: 403.7;Inhibitory neurons: 167.3;Oligodendrocytes: 706.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "myeloid DC: 13.6;naive CD4 T-cell: 16.3" "Group enriched" "Detected in many" 12 "dendritic cells: 13.6;T-cells: 16.3" "Cell line enhanced" "Detected in many" "ASC TERT1: 93.7;BJ: 67.8;fHDF/TERT166: 77.5;LHCN-M2: 189.9;U-2 OS: 58.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019128, HPA057255" Enhanced Supported "Centriolar satellite,Cytosol" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol "Centriolar satellite" "HPA019128: AB_1844682, HPA057255: AB_2683383" "unprognostic (4.07e-2)" "unprognostic (4.23e-1)" "unprognostic (1.13e-1)" "unprognostic (2.85e-2)" "unprognostic (1.03e-1)" "unprognostic (6.04e-2)" "unprognostic (2.20e-1)" "unprognostic (2.01e-2)" "unprognostic (1.84e-1)" "unprognostic (1.51e-1)" "unprognostic (1.91e-2)" "prognostic favorable (3.88e-4)" "unprognostic (3.56e-3)" "unprognostic (6.17e-4)" "unprognostic (1.18e-1)" "unprognostic (5.96e-2)" "unprognostic (6.76e-2)" 1.0 1.6 75.9 1.5 101.2 3.9 18.9 19.4 115.0 1.3 0.8 2.6 1.0 0.7 0.6 1.0 1.0 1.0 1.0 121.0 31.5 1.4 0.1 0.4 2.3 27.2 30.2 0.5 1.6 0.7 3.4 1.2 25.6 2.3 1.0 3.0 3.0 2.1 0.3 2.0 1.0 0.8 31.0 2.1 2.4 9.4 31.7 0.8 1.1 0.8 1.5 0.7 0.7 81.1 0.2 3.6 2.9 0.1 34.8 93.7 1.2 67.8 14.4 10.8 4.6 0.5 1.7 0.6 0.5 77.5 4.4 0.4 0.2 0.0 5.5 2.6 0.7 0.5 1.2 0.4 1.8 0.6 0.2 11.6 0.5 2.1 4.3 37.9 31.5 0.3 0.9 0.7 189.9 0.7 0.0 0.6 3.9 18.4 24.5 1.7 7.1 1.6 29.3 1.1 15.3 3.5 0.2 0.2 4.4 0.3 0.3 0.5 7.9 26.1 58.4 1.6 2.2 15.2 14.7 0.3 5.2 3.5 9.8 1.2 0.8 0.1 3.8 0.2 0.5 0.9 3.6 1.9 13.6 0.9 16.3 9.1 0.6 0.2 0.2 1.5 1.7 2.3 75.9 101.2 19.4 115.0 121.0 31.5 27.2 30.2 25.6 31.0 31.7 81.1 0.7 0.0 0.0 10.7 0.4 0.3 0.4 0.0 1.2 1.3 54.0 27.3 1.1 0.0 0.0 1.8 0.0 1.9 5.6 0.3 7.9 0.3 150.5 1.1 0.1 1.3 12.0 0.8 403.7 0.6 56.3 1.5 1.1 1.7 0.0 0.0 0.4 0.0 2.4 13.5 167.3 0.3 0.0 0.0 0.6 29.2 1.2 0.4 3.6 41.2 1.9 0.0 47.4 60.8 706.6 0.1 1.1 0.7 0.1 2.9 0.0 7.8 0.0 0.3 0.0 1.2 6.3 10.2 91.0 0.0 0.3 2.9 4.2 0.1 0.2 0.1 AK6 CINAP ENSG00000085231 "Adenylate kinase 6" Q9Y3D8 5 69350984-69370013 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal tubular cells: 185.9;Late spermatids: 275.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005361, HPA070217" Supported Supported "Nuclear speckles,Centrosome,Cytosol" No No "Cluster 12: Non-specific - Basic cellular processes" "Cluster 18: Non-specific - Mitochondria" "Cluster 16: U-266 - Nucleosome" "Cluster 25: Spermatids - Spermatogenesis" "Nuclear speckles" "Centrosome, Cytosol" "CAB005361: AB_2302969, HPA070217: " "unprognostic (5.47e-2)" "unprognostic (1.54e-2)" "unprognostic (1.48e-1)" "unprognostic (8.58e-2)" "unprognostic (8.73e-2)" "unprognostic (4.09e-2)" "prognostic unfavorable (9.54e-4)" "unprognostic (1.79e-1)" "unprognostic (3.41e-2)" "unprognostic (6.21e-2)" "unprognostic (2.55e-2)" "unprognostic (2.25e-2)" "unprognostic (1.14e-2)" "unprognostic (1.31e-1)" "unprognostic (1.84e-1)" "unprognostic (2.22e-1)" "unprognostic (2.55e-2)" 46.0 58.0 18.7 12.5 19.6 11.6 40.0 20.6 27.1 26.1 19.8 40.8 15.2 32.4 21.6 29.7 29.6 7.7 48.4 19.8 20.3 54.9 46.6 29.5 13.0 19.7 20.1 32.6 35.8 11.6 28.6 12.1 19.5 32.9 12.6 23.2 30.9 8.3 79.8 20.6 30.1 9.5 18.7 28.0 36.4 43.3 19.5 13.3 33.0 23.3 12.5 35.5 28.0 20.7 40.3 18.8 28.0 42.6 43.6 26.3 51.1 59.3 18.6 23.8 30.7 56.0 35.5 82.1 54.9 23.4 62.2 14.0 37.2 23.3 40.0 33.1 15.7 40.7 47.8 44.9 33.0 49.5 17.1 14.0 33.3 23.0 37.0 25.0 14.8 45.8 36.6 29.3 28.6 42.1 50.2 31.4 25.0 17.9 10.5 55.8 34.5 44.5 40.3 31.3 14.4 13.3 28.2 26.4 44.6 21.3 25.1 54.7 29.5 20.4 34.6 41.4 47.6 33.1 74.4 75.3 29.8 69.3 28.9 25.2 16.8 20.1 19.2 22.1 20.3 29.8 22.8 24.9 24.8 26.1 24.5 26.3 2.7 24.1 21.0 29.9 25.8 13.3 18.7 19.6 20.6 27.1 19.8 20.3 19.7 20.1 19.5 18.7 19.5 20.7 51.5 22.4 30.0 14.0 33.9 0.0 95.7 0.0 33.6 19.8 57.3 86.6 55.6 18.6 16.7 23.9 10.4 86.7 27.2 16.8 185.9 75.6 174.9 36.4 34.6 38.6 9.7 29.2 14.8 78.5 95.1 47.3 16.8 30.2 21.5 31.7 30.7 42.5 71.3 20.2 15.4 21.3 0.0 30.6 0.0 275.9 33.5 32.2 0.0 6.5 42.4 58.7 34.0 13.0 17.0 59.1 25.5 32.0 29.4 116.6 48.6 149.8 18.2 29.3 52.6 40.9 50.0 56.5 37.9 24.3 0.0 66.2 27.6 44.7 32.9 88.1 AK7 "CFAP75, FAP75, FLJ32864" ENSG00000140057 "Adenylate kinase 7" Q96M32 14 96392128-96489427 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cilium biogenesis/degradation" "Kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "fallopian tube: 24.3" "Group enriched" "Detected in many" 4 "Endometrial ciliated cells: 97.9;Respiratory ciliated cells: 137.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 23 "basophil: 9.0" "Lineage enriched" "Detected in single" 29 "granulocytes: 9.0" "Cell line enhanced" "Detected in many" "BEWO: 17.0;CAPAN-2: 15.1;MCF7: 49.5;REH: 35.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA003543 Enhanced NA NA "Cluster 38: Basophils - Unknown function" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 49: Ciliated cells - Cilium organization" "HPA003543: AB_1078117" "unprognostic (4.18e-3)" "unprognostic (1.14e-1)" "unprognostic (9.40e-3)" "prognostic favorable (3.18e-4)" "unprognostic (4.98e-5)" "unprognostic (8.41e-2)" "unprognostic (9.81e-3)" "unprognostic (1.29e-1)" "unprognostic (9.02e-2)" "unprognostic (3.65e-4)" "unprognostic (8.64e-2)" "unprognostic (1.89e-1)" "prognostic favorable (1.14e-4)" "unprognostic (2.00e-2)" "unprognostic (1.23e-2)" "unprognostic (4.01e-2)" "unprognostic (2.25e-3)" 0.7 2.6 2.0 0.6 3.1 1.5 1.4 1.1 1.7 1.7 13.2 2.1 1.9 2.1 3.9 1.5 24.3 2.6 0.7 2.2 5.2 4.5 1.6 4.2 0.6 6.9 9.4 0.4 2.2 6.9 5.1 0.5 5.6 0.9 1.6 3.0 1.0 1.3 0.3 6.1 1.2 1.1 4.4 3.3 2.8 7.6 5.0 0.5 2.7 0.0 0.4 0.5 1.0 4.2 0.2 4.9 2.0 1.5 0.8 2.6 17.0 0.3 0.6 0.3 0.3 0.5 15.1 0.4 0.3 0.0 0.3 1.9 4.7 0.2 0.1 2.2 0.4 0.4 2.4 0.2 0.8 0.1 0.3 0.2 0.6 2.5 0.1 0.8 0.2 1.4 0.2 0.3 0.3 49.5 0.3 0.3 0.8 2.2 1.0 35.2 0.3 0.4 7.6 0.3 3.1 6.7 1.9 0.6 0.1 1.8 4.2 0.2 0.1 0.4 0.2 0.6 0.2 0.6 2.3 0.2 0.2 0.0 0.7 9.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.3 0.0 0.2 0.1 0.1 0.3 0.2 0.2 0.0 0.0 0.1 2.0 3.1 1.1 1.7 2.2 5.2 6.9 9.4 5.6 4.4 5.0 4.2 1.6 6.4 4.1 0.7 0.8 1.8 0.9 3.6 1.8 0.2 0.9 0.3 0.4 4.3 12.3 7.3 2.1 0.7 0.1 1.4 3.9 3.2 18.7 97.9 1.7 1.9 1.2 6.9 2.0 1.1 1.7 0.8 5.1 11.6 0.0 0.1 0.7 2.4 0.2 0.0 2.4 0.3 4.1 0.3 0.4 4.1 0.0 0.5 1.8 0.0 0.0 0.6 0.0 0.5 3.7 0.5 0.1 0.0 0.0 0.5 1.0 3.4 137.1 1.8 0.0 0.4 1.6 25.4 9.1 0.7 3.0 2.9 0.2 1.5 1.2 0.6 AK8 "C9orf98, FLJ32704" ENSG00000165695 "Adenylate kinase 8" Q96MA6 9 132725578-132878777 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "epididymis: 19.3;fallopian tube: 25.8;testis: 15.9" "Cell type enhanced" "Detected in many" "Early spermatids: 102.3;Endometrial ciliated cells: 26.1;Late spermatids: 134.1;monocytes: 49.2;Respiratory ciliated cells: 36.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 30 "memory B-cell: 6.2;naive B-cell: 4.9;NK-cell: 3.1" "Group enriched" "Detected in many" 30 "B-cells: 6.2;NK-cells: 3.1" "Cell line enhanced" "Detected in some" "MCF7: 3.1;RPTEC TERT1: 3.6;T-47d: 2.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA021443, HPA023894" Enhanced NA NA "Cluster 19: B-cells - Humoral immune response" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 6: T47d - Mammary gland" "Cluster 3: Monocytes - Immune response regulation" "HPA021443: AB_1845852, HPA023894: AB_1845854" "unprognostic (4.14e-2)" "unprognostic (1.20e-4)" "unprognostic (1.31e-2)" "unprognostic (1.70e-3)" "unprognostic (2.16e-1)" "unprognostic (2.38e-2)" "unprognostic (1.14e-1)" "unprognostic (3.18e-1)" "unprognostic (3.43e-1)" "unprognostic (1.71e-1)" "unprognostic (7.51e-2)" "unprognostic (1.42e-1)" "prognostic favorable (1.61e-4)" "unprognostic (9.89e-2)" "unprognostic (3.22e-2)" "unprognostic (2.03e-1)" "unprognostic (1.43e-1)" 0.7 1.2 2.2 0.5 2.5 0.1 1.0 1.7 2.3 2.5 5.6 0.5 0.0 1.3 19.3 0.9 25.8 1.3 0.2 2.5 3.1 2.3 0.1 2.1 0.6 4.2 6.8 1.6 0.7 3.1 1.8 0.4 4.5 0.9 0.3 2.7 1.7 2.7 0.0 1.6 0.1 0.7 3.7 0.1 0.8 15.9 3.3 1.5 4.7 0.2 4.3 0.5 0.5 2.5 1.1 0.7 0.3 1.6 0.2 0.4 0.3 0.1 0.1 0.1 0.0 0.3 1.2 0.0 0.3 0.2 0.3 0.2 0.3 0.2 0.1 0.0 0.2 0.0 0.0 0.1 0.7 0.0 0.0 1.0 0.5 0.3 0.4 0.4 0.0 0.8 0.0 0.0 0.3 3.1 0.7 0.3 0.1 0.4 0.5 0.0 0.0 0.0 3.6 0.0 0.6 0.6 1.5 0.0 0.2 0.3 2.3 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.2 0.0 0.0 0.0 4.9 0.1 0.0 0.0 3.1 0.0 0.0 0.0 0.1 2.2 2.5 1.7 2.3 2.5 3.1 4.2 6.8 4.5 3.7 3.3 2.5 0.2 3.2 1.7 9.4 1.5 0.5 0.5 3.9 0.6 0.3 0.8 0.5 1.2 0.0 3.4 3.7 0.0 0.4 0.1 0.3 0.0 2.8 102.3 26.1 1.1 1.1 0.0 0.4 4.9 0.5 0.3 0.8 0.0 1.3 0.0 0.4 0.7 0.0 1.7 0.0 5.1 0.9 2.0 0.3 0.3 134.1 6.2 1.8 1.8 0.0 49.2 0.8 0.0 4.5 5.0 1.2 0.3 4.1 0.0 0.6 0.0 6.0 36.7 1.8 0.0 0.8 2.7 24.3 5.6 0.4 1.6 0.4 0.2 1.0 0.5 0.7 AK9 "AKD1, AKD2, C6orf199, C6orf224, dJ70A9.1, FLJ25791, FLJ42177, MGC26954" ENSG00000155085 "Adenylate kinase 9" Q5TCS8 6 109492856-109691217 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Nucleotide metabolism" "Kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 76.3;Respiratory ciliated cells: 152.0;Spermatocytes: 174.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Not detected" "Not detected" "Region enhanced" "Detected in some" "midbrain: 3.6" "HPA030804, HPA030805, HPA031779, HPA031781, HPA036324, HPA036711" Enhanced Enhanced "Nucleoplasm,Nuclear membrane" NA NA "Cluster 37: B-cells - Transcription" "Cluster 77: Retina - Visual perception" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 49: Ciliated cells - Cilium organization" "Nucleoplasm, Nuclear membrane" "HPA030804: AB_2673617, HPA030805: AB_2673618, HPA031779: AB_10603674, HPA031781: AB_2674044, HPA036324: AB_2675060, HPA036711: AB_2675265" "unprognostic (9.68e-3)" "unprognostic (2.15e-1)" "unprognostic (1.66e-2)" "unprognostic (2.36e-2)" "unprognostic (3.42e-1)" "unprognostic (7.28e-2)" "unprognostic (1.41e-3)" "unprognostic (6.76e-3)" "unprognostic (1.89e-1)" "unprognostic (3.50e-2)" "unprognostic (1.67e-4)" "unprognostic (2.58e-1)" "unprognostic (2.98e-2)" "unprognostic (1.24e-1)" "unprognostic (1.30e-1)" "unprognostic (8.39e-2)" "unprognostic (5.56e-2)" 3.5 3.1 8.1 3.3 9.9 3.7 4.8 13.5 17.2 3.5 10.9 4.6 3.6 4.3 7.6 4.3 7.9 3.5 4.9 6.4 11.0 5.3 3.1 4.1 4.2 8.8 10.7 3.6 3.4 9.2 7.7 3.1 9.5 3.9 4.5 14.1 5.1 3.9 4.8 3.9 3.6 3.9 10.7 4.0 4.5 16.6 8.7 7.6 6.9 3.5 3.6 3.4 3.2 13.4 2.3 1.6 6.6 11.5 6.1 3.7 4.8 3.5 4.3 3.6 4.9 2.6 4.6 4.9 1.7 3.4 7.9 3.7 1.9 3.9 7.6 10.2 4.0 3.8 3.8 2.6 4.8 4.4 2.3 3.1 7.3 6.6 8.6 8.8 4.2 7.2 3.6 4.0 2.7 4.7 4.1 3.2 1.5 5.1 2.5 5.5 3.7 4.7 5.0 4.3 7.8 6.4 4.2 3.9 5.9 3.7 5.1 5.8 5.2 3.1 2.2 5.1 2.3 2.0 1.8 2.8 6.8 5.9 2.0 17.1 2.8 7.1 5.1 1.5 4.4 13.1 4.9 6.2 2.1 10.8 6.2 5.4 5.6 5.6 4.8 3.1 3.9 1.6 8.1 9.9 13.5 17.2 6.4 11.0 8.8 10.7 9.5 10.7 8.7 13.4 13.3 28.9 17.2 21.2 13.6 2.7 7.7 14.7 3.4 18.3 10.4 6.7 18.9 5.7 19.9 9.2 14.6 3.4 8.6 13.1 0.0 9.1 70.9 76.3 5.4 10.0 19.8 4.2 34.8 4.5 1.5 6.0 12.2 7.3 22.1 10.6 8.9 2.1 3.6 20.2 37.0 15.5 14.2 5.3 3.9 41.7 7.5 5.6 5.4 25.3 5.0 12.6 18.6 22.6 46.9 7.4 8.9 6.4 5.5 5.6 22.9 6.8 152.0 50.7 26.3 9.1 6.9 174.3 34.1 4.0 2.6 5.6 10.3 4.7 11.4 7.9 AKT1 "AKT, PKB, PRKBA, RAC, RAC-alpha" ENSG00000142208 "AKT serine/threonine kinase 1" P31749 14 104769349-104795751 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins, Transporters" "Apoptosis, Carbohydrate metabolism, Glucose metabolism, Glycogen biosynthesis, Glycogen metabolism, Neurogenesis, Sugar transport, Translation regulation, Transport" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "eosinophil: 61.5" "Lineage enriched" "Detected in all" 5 "granulocytes: 61.5" "Cell line enhanced" "Detected in all" "MCF7: 558.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002891, CAB003765" Supported Supported Nucleoplasm,Microtubules NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 18: Non-specific - Mitochondria" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 30: Mammary glandular cells - Lactation" Nucleoplasm Microtubules "CAB003765: AB_562035, HPA002891: AB_1078123" "unprognostic (3.30e-2)" "unprognostic (4.27e-2)" "unprognostic (1.98e-1)" "unprognostic (1.84e-1)" "unprognostic (3.70e-1)" "unprognostic (9.17e-3)" "unprognostic (1.55e-3)" "unprognostic (1.21e-1)" "unprognostic (1.47e-1)" "prognostic favorable (4.83e-4)" "unprognostic (3.58e-2)" "unprognostic (1.90e-2)" "prognostic favorable (2.12e-4)" "unprognostic (7.14e-2)" "unprognostic (1.28e-1)" "unprognostic (1.06e-1)" "unprognostic (2.41e-1)" 71.5 102.7 45.9 57.7 45.5 51.2 61.2 43.7 53.2 52.0 50.4 85.0 50.8 59.5 23.2 70.7 53.7 50.0 105.9 45.2 44.3 54.3 97.3 69.2 51.9 50.5 45.7 43.7 94.3 53.0 35.9 55.4 45.0 67.2 39.6 25.1 67.7 73.0 58.1 45.0 53.3 63.4 47.4 63.7 77.8 23.9 48.0 52.4 52.3 64.9 40.3 72.6 48.4 43.3 77.3 150.5 124.6 186.9 95.2 97.7 136.9 142.3 171.5 204.6 163.6 96.8 92.8 91.2 105.5 196.6 102.8 99.4 89.5 131.9 90.1 214.3 36.2 70.6 90.4 103.2 104.6 117.5 178.0 140.0 109.1 102.9 68.1 98.2 154.4 87.5 62.1 102.2 134.1 558.3 145.3 146.8 32.6 153.5 107.2 137.5 111.9 60.5 94.8 189.5 141.2 117.2 117.3 152.2 88.9 56.8 195.7 170.2 123.5 133.2 63.2 192.3 145.1 105.4 52.6 80.7 113.7 96.7 162.0 6.4 9.9 61.5 10.0 10.3 7.2 5.5 8.7 11.4 7.0 7.2 4.6 10.1 22.6 11.0 12.4 10.0 9.0 6.3 45.9 45.5 43.7 53.2 45.2 44.3 50.5 45.7 45.0 47.4 48.0 43.3 45.8 16.0 27.4 16.6 13.7 12.4 20.0 17.3 15.9 26.3 58.0 39.9 16.1 32.9 17.7 22.0 12.5 19.4 54.2 40.9 13.7 23.6 1.9 17.9 28.1 27.5 30.0 11.3 8.2 35.2 31.8 24.0 26.0 24.8 2.5 40.4 23.2 42.9 23.2 42.1 13.0 37.3 22.4 23.3 21.4 3.3 28.6 28.0 10.6 6.5 23.1 51.2 24.7 8.0 9.6 53.3 22.1 30.9 10.3 38.8 23.5 17.9 14.2 26.6 26.3 24.9 29.1 1.8 5.3 16.2 13.9 23.4 23.3 34.0 33.7 33.4 AKT2 PKBβ ENSG00000105221 "AKT serine/threonine kinase 2" P31751 19 40230317-40285536 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Apoptosis, Carbohydrate metabolism, Glucose metabolism, Glycogen biosynthesis, Glycogen metabolism, Sugar transport, Translation regulation, Transport" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Diabetes mellitus, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004204, HPA064521" Uncertain Supported Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 17: Basophils - Unknown function" "Cluster 52: Non-specific - Ribosome" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Vesicles, Cytosol" "CAB004204: AB_626659, HPA064521: AB_2685278" "unprognostic (6.13e-2)" "unprognostic (2.21e-1)" "unprognostic (1.56e-1)" "prognostic unfavorable (1.05e-6)" "unprognostic (2.85e-1)" "unprognostic (6.40e-3)" "unprognostic (9.59e-2)" "unprognostic (1.22e-2)" "unprognostic (2.98e-2)" "unprognostic (2.49e-2)" "unprognostic (3.02e-1)" "prognostic unfavorable (4.74e-4)" "unprognostic (1.30e-2)" "unprognostic (1.89e-1)" "unprognostic (3.28e-1)" "unprognostic (6.16e-2)" "unprognostic (2.00e-1)" 62.8 40.0 31.7 37.3 31.3 48.4 38.6 58.3 40.0 49.8 55.1 42.3 24.5 43.5 49.4 42.5 46.1 25.1 40.8 31.5 24.5 52.2 59.2 30.7 38.1 32.0 26.0 53.9 41.9 58.5 47.8 27.6 26.3 41.2 23.3 41.2 32.5 45.0 101.3 39.4 35.6 34.2 22.1 38.1 33.1 29.7 28.0 53.4 100.1 118.7 37.0 39.8 41.5 35.2 66.2 160.1 63.1 61.5 72.0 88.9 32.5 41.7 63.5 87.6 77.9 71.8 60.8 67.4 36.8 96.3 37.2 28.2 66.8 90.0 56.1 62.5 74.3 43.4 116.5 44.7 45.8 50.7 50.5 82.7 53.6 58.6 56.4 71.9 19.0 73.0 57.3 67.5 49.8 54.6 81.1 24.7 31.7 73.7 41.5 54.2 32.1 48.5 68.3 105.7 82.7 49.8 43.3 75.0 35.0 62.5 59.8 64.9 18.8 52.7 51.5 47.3 67.6 61.5 59.0 56.4 52.6 59.7 44.3 5.7 2.6 2.1 2.2 1.2 2.2 1.9 1.8 1.5 1.7 2.9 1.7 2.6 4.0 1.7 1.6 4.9 1.6 1.7 31.7 31.3 58.3 40.0 31.5 24.5 32.0 26.0 26.3 22.1 28.0 35.2 18.1 16.0 15.9 51.2 33.0 23.8 23.9 20.9 26.2 67.6 25.3 23.9 31.2 30.0 18.1 60.7 41.7 31.3 26.0 23.7 21.5 19.7 5.5 26.2 26.7 17.4 19.2 19.1 30.4 30.4 25.2 27.9 20.9 25.8 14.0 44.2 13.9 87.5 22.3 60.6 25.3 20.1 22.4 23.2 17.5 10.5 42.9 20.0 23.2 23.4 21.7 46.2 50.4 41.7 40.6 24.8 16.9 26.7 30.4 29.7 21.8 24.8 24.9 97.4 19.7 29.3 25.0 14.8 15.6 31.1 27.4 38.7 23.1 56.9 23.3 29.4 AKT3 "PKBG, PRKBG, RAC-gamma" ENSG00000117020 "AKT serine/threonine kinase 3" Q9Y243 1 243488233-243851079 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 59.9" "Group enriched" "Detected in many" 6 "Astrocytes: 457.4;Excitatory neurons: 756.1;Inhibitory neurons: 514.5;Microglial cells: 414.1;Oligodendrocyte precursor cells: 633.3;Oligodendrocytes: 475.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB013090, HPA026441" Approved Supported Cytosol NA NA "Cluster 11: Basophils - Unknown function" "Cluster 21: Non-specific - Transcription" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "CAB013090: AB_2533692, HPA026441: AB_1844711" "unprognostic (1.33e-1)" "unprognostic (1.27e-1)" "unprognostic (2.40e-2)" "unprognostic (8.45e-2)" "unprognostic (1.89e-1)" "unprognostic (1.75e-1)" "unprognostic (1.96e-1)" "unprognostic (3.77e-1)" "unprognostic (2.32e-1)" "unprognostic (2.28e-1)" "unprognostic (5.47e-3)" "unprognostic (1.37e-1)" "unprognostic (6.71e-2)" "unprognostic (3.64e-3)" "unprognostic (1.29e-1)" "unprognostic (8.14e-2)" "prognostic unfavorable (9.27e-4)" 19.3 9.7 13.4 6.0 17.0 3.8 15.5 59.9 36.6 20.0 0.0 24.5 2.6 22.7 8.6 5.9 20.3 8.2 11.8 22.8 5.6 11.2 4.7 15.3 5.9 1.2 3.9 26.4 4.5 7.4 13.9 13.1 7.4 15.8 4.9 17.0 5.1 15.6 5.9 6.3 11.8 15.7 0.8 8.1 10.2 9.7 20.3 7.0 14.4 11.5 4.6 18.8 14.8 31.1 30.8 7.2 31.0 0.4 16.9 20.6 13.9 20.8 22.5 11.8 12.9 1.1 13.9 0.5 3.0 28.9 12.1 1.2 16.3 8.5 18.9 9.0 15.3 1.0 1.0 0.3 11.7 0.6 6.5 11.3 0.3 15.5 16.9 30.3 30.2 7.2 0.5 1.1 9.0 0.9 7.6 3.3 14.4 0.3 5.1 4.2 19.7 0.6 4.8 4.1 31.4 41.9 1.3 0.5 40.1 19.1 1.9 21.5 25.6 22.7 17.7 1.1 19.5 4.6 4.6 7.1 19.4 5.2 25.3 1.3 0.8 0.1 0.6 0.1 1.1 0.6 0.6 0.6 0.3 0.8 0.6 0.7 0.7 1.4 0.3 0.5 0.1 0.3 13.4 17.0 59.9 36.6 22.8 5.6 1.2 3.9 7.4 0.8 20.3 31.1 65.4 3.2 2.2 457.4 22.2 2.4 15.0 1.3 17.1 43.6 6.1 5.1 5.4 4.3 2.7 27.6 33.3 11.0 24.4 0.0 0.0 11.6 82.8 1.7 35.5 43.7 0.0 5.0 756.1 1.7 8.0 27.9 2.6 1.1 5.1 29.7 48.2 0.6 2.9 42.1 514.5 0.0 2.0 10.5 12.5 72.8 27.4 9.5 7.2 414.1 8.6 20.1 19.6 633.3 475.9 0.7 0.0 35.3 14.4 27.0 0.0 6.9 0.3 35.0 19.7 40.1 35.6 15.0 14.6 1.7 1.7 12.4 27.8 8.3 0.0 12.2 ALAS1 "ALAS, ALAS3" ENSG00000023330 "5'-aminolevulinate synthase 1" P13196 3 52198086-52214327 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Heme biosynthesis" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 720.5;liver: 548.8" "Cell type enhanced" "Detected in all" "Hepatocytes: 243.1;Syncytiotrophoblasts: 309.2;Theca cells: 187.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 233.9" "Lineage enriched" "Detected in all" 5 "granulocytes: 233.9" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017498, HPA035860" Enhanced Supported Nucleoplasm,Mitochondria NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 15: RT4 - Unknown function" "Cluster 15: Hepatocytes - Hemostasis" Mitochondria Nucleoplasm "CAB017498: AB_2225629, HPA035860: AB_10672992" "unprognostic (1.17e-1)" "unprognostic (1.65e-1)" "unprognostic (1.50e-1)" "unprognostic (7.09e-2)" "unprognostic (2.33e-1)" "unprognostic (6.21e-2)" "prognostic favorable (1.82e-5)" "unprognostic (3.98e-2)" "unprognostic (1.26e-1)" "unprognostic (2.31e-2)" "unprognostic (9.86e-2)" "unprognostic (5.64e-2)" "prognostic favorable (6.06e-7)" "unprognostic (8.45e-2)" "unprognostic (3.91e-2)" "unprognostic (1.07e-1)" "unprognostic (1.75e-2)" 34.5 720.5 24.8 23.9 25.1 176.7 28.7 37.9 82.5 20.5 35.7 43.6 44.9 19.0 28.1 36.4 15.3 32.7 116.2 26.6 28.1 45.7 548.8 47.8 22.9 27.2 25.4 17.1 19.6 60.3 15.7 36.8 33.2 23.1 41.6 20.6 42.8 27.2 110.9 24.3 39.3 23.9 24.9 19.5 45.9 18.6 31.8 23.5 22.1 106.6 28.2 73.8 23.5 28.3 36.2 55.0 38.0 35.4 57.9 43.1 103.1 51.8 47.7 67.6 65.3 73.6 66.2 33.6 12.7 36.4 137.0 20.9 55.1 42.6 54.7 65.9 21.6 43.2 41.2 56.4 81.8 70.8 83.0 54.0 39.1 107.7 35.7 25.0 62.8 57.7 25.8 27.0 62.4 29.5 33.9 107.3 33.0 41.1 93.4 20.0 23.9 53.3 59.8 213.9 20.2 13.3 83.9 40.9 47.2 30.5 23.5 99.9 45.7 37.6 37.1 78.5 76.2 39.5 73.8 50.5 42.1 75.5 61.1 233.9 33.4 103.2 22.9 42.9 37.4 23.1 23.9 26.0 29.8 21.5 21.1 23.3 49.6 30.9 39.0 17.1 35.7 25.1 24.8 25.1 37.9 82.5 26.6 28.1 27.2 25.4 33.2 24.9 31.8 28.3 28.4 35.3 60.3 5.2 14.9 17.3 17.2 36.1 15.9 16.6 28.6 19.6 107.5 25.8 37.7 23.9 4.2 81.9 25.1 68.5 56.7 35.5 10.2 20.2 9.3 27.6 34.6 11.2 6.2 31.3 28.2 19.6 42.3 25.3 95.4 13.1 18.5 243.1 69.1 11.8 6.2 24.3 34.6 13.0 20.8 4.1 13.4 36.4 5.4 8.4 49.1 9.7 11.3 4.0 8.4 42.3 28.1 16.6 14.0 16.0 35.6 36.1 40.6 9.2 13.1 9.1 27.5 25.5 22.3 21.4 16.2 309.2 25.1 187.2 24.3 26.4 ALAS2 ASB ENSG00000158578 "5'-aminolevulinate synthase 2" P22557 X 55009055-55030977 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Heme biosynthesis" "Acyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 13 "bone marrow: 606.2" "Cell type enriched" "Detected in some" 166 "Erythroid cells: 2366.7" "Cancer enhanced" "Detected in single" "renal cancer: 0.6" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in single" 6 "plasmacytoid DC: 1.6" "Lineage enriched" "Detected in single" 6 "dendritic cells: 1.6" "Group enriched" "Detected in some" 93 "HEL: 71.7;K-562: 85.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 1: K-562 - Erythropoiesis" "Cluster 6: Erythroid cells - Oxygen transport" "unprognostic (7.82e-2)" "unprognostic (2.01e-1)" "unprognostic (6.41e-2)" "unprognostic (1.14e-2)" "unprognostic (2.98e-3)" "unprognostic (5.59e-2)" "unprognostic (1.37e-1)" "unprognostic (1.47e-1)" "unprognostic (8.68e-2)" "unprognostic (4.07e-2)" "unprognostic (2.72e-1)" "unprognostic (3.45e-1)" "unprognostic (2.32e-2)" "unprognostic (6.63e-3)" "unprognostic (4.39e-1)" "unprognostic (1.23e-1)" "unprognostic (1.89e-1)" 1.9 0.5 0.9 0.4 0.9 606.2 0.6 0.8 2.5 0.2 1.6 0.5 0.6 0.1 0.0 0.8 1.1 0.8 3.4 0.7 0.8 2.5 3.2 5.2 0.3 1.8 1.2 0.4 0.3 0.0 1.2 44.9 1.6 0.2 0.0 0.2 1.0 0.2 0.5 0.6 0.3 0.1 1.6 25.2 0.2 0.2 1.0 1.0 1.2 18.2 0.0 0.6 0.7 1.3 0.1 0.0 0.0 0.8 0.1 0.0 0.5 0.0 0.0 0.0 0.0 0.2 0.3 0.2 0.1 0.0 0.0 0.6 0.0 0.0 0.0 0.1 0.6 71.7 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 85.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.4 0.0 0.2 0.2 0.1 0.4 0.0 0.2 0.1 0.0 0.4 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.6 0.4 0.1 0.1 0.3 0.1 0.0 0.0 0.0 0.1 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 1.6 0.0 5.9 0.9 0.9 0.8 2.5 0.7 0.8 1.8 1.2 1.6 1.6 1.0 1.3 0.1 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 4.3 0.0 0.0 0.0 0.4 0.0 0.0 0.0 4.8 0.0 0.1 0.0 0.3 1.8 2366.7 0.0 0.2 1.8 0.3 0.0 0.1 0.0 0.0 1.4 1.3 2.1 0.0 0.0 0.0 0.0 5.8 0.0 0.0 0.0 7.3 14.2 1.0 0.0 0.0 1.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.4 0.5 0.0 0.0 0.0 0.0 0.7 1.1 0.0 0.0 0.1 ALDH18A1 "GSAS, P5CS, PYCS, SPG9" ENSG00000059573 "Aldehyde dehydrogenase 18 family member A1" P54886 10 95605941-95656711 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Amino-acid biosynthesis, Proline biosynthesis" "Kinase, Multifunctional enzyme, Oxidoreductase, Transferase" "Disease variant, Hereditary spastic paraplegia, Mental retardation, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "salivary gland: 120.1" "Cell type enhanced" "Detected in many" "Distal enterocytes: 80.5;Granulosa cells: 81.6;Proximal enterocytes: 79.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008333, HPA012604" Approved Enhanced Mitochondria NA NA 48000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 40: Granulosa cells - Unknown function" Mitochondria "HPA008333: AB_1078125, HPA012604: AB_1844721" "unprognostic (5.97e-3)" "unprognostic (2.08e-2)" "unprognostic (5.75e-2)" "prognostic favorable (4.20e-4)" "unprognostic (1.60e-2)" "unprognostic (1.06e-1)" "unprognostic (8.30e-3)" "unprognostic (7.08e-2)" "unprognostic (4.06e-2)" "unprognostic (8.04e-2)" "unprognostic (1.30e-1)" "unprognostic (1.81e-1)" "prognostic unfavorable (3.60e-9)" "unprognostic (1.02e-3)" "unprognostic (6.57e-2)" "unprognostic (1.29e-3)" "unprognostic (6.43e-2)" 15.3 16.1 12.2 21.2 12.6 16.7 20.2 12.4 13.1 33.4 21.0 51.9 89.3 18.5 30.9 21.0 21.9 25.2 11.5 12.2 13.6 17.7 24.3 10.8 22.0 12.4 14.7 16.7 61.8 33.5 28.2 26.3 13.1 24.2 49.3 11.4 120.1 24.9 4.3 22.4 73.1 26.3 12.7 12.1 40.5 11.7 14.0 17.2 37.5 5.5 26.9 25.2 14.3 13.1 66.5 61.6 57.9 152.7 76.0 72.9 62.2 75.6 112.8 75.1 93.7 124.4 51.6 223.7 68.9 119.7 36.2 85.6 117.1 77.8 84.6 64.0 92.0 71.2 40.5 177.9 49.7 125.6 76.1 77.0 46.8 61.5 119.1 124.5 79.9 82.6 67.5 46.0 57.1 95.0 114.5 80.5 68.6 109.2 60.7 105.9 66.3 76.9 88.3 49.7 57.5 56.9 60.1 47.1 56.9 66.0 70.5 57.9 66.7 31.1 49.0 80.9 88.2 52.4 41.7 135.8 60.4 142.8 40.7 0.1 2.6 0.2 27.3 5.2 28.7 23.0 24.5 28.3 9.6 16.1 20.7 23.1 0.5 26.3 8.3 5.9 25.8 15.5 12.2 12.6 12.4 13.1 12.2 13.6 12.4 14.7 13.1 12.7 14.0 13.1 4.6 6.4 9.2 7.2 12.6 11.2 8.3 8.9 14.2 6.3 15.6 12.4 4.6 11.5 14.3 20.2 0.0 43.9 6.7 80.5 1.9 13.7 1.3 12.7 18.1 8.0 19.8 17.9 15.7 21.1 31.6 16.2 18.8 16.9 8.2 81.6 5.3 27.3 11.5 10.1 13.6 41.3 8.2 3.5 3.8 1.6 9.3 3.5 16.0 11.2 2.6 7.1 8.2 17.6 12.8 11.7 56.4 12.0 30.1 18.4 79.4 8.4 15.2 3.4 0.0 10.5 10.1 8.2 9.9 17.6 8.1 30.2 9.0 10.8 38.7 9.4 ALG1 "CDG1K, HMAT1, HMT-1, Mat-1" ENSG00000033011 "ALG1 chitobiosyldiphosphodolichol beta-mannosyltransferase" Q9BT22 16 5033923-5087379 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Congenital disorder of glycosylation, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA060392 Approved Approved "Nucleoli fibrillar center,Endoplasmic reticulum" "Intracellular and membrane" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 29: Non-specific - Vesicular transport" "Cluster 25: RPMI-8226 - Immune response" "Cluster 55: Plasma cells - Humoral immune response" "Endoplasmic reticulum" "Nucleoli fibrillar center" "HPA060392: AB_2684273" "unprognostic (1.66e-2)" "unprognostic (5.18e-1)" "prognostic favorable (5.79e-4)" "unprognostic (1.55e-2)" "unprognostic (2.10e-2)" "unprognostic (3.22e-2)" "unprognostic (2.84e-2)" "unprognostic (2.52e-1)" "unprognostic (1.18e-2)" "unprognostic (1.17e-1)" "unprognostic (2.15e-1)" "unprognostic (2.87e-1)" "unprognostic (5.27e-2)" "unprognostic (1.02e-2)" "prognostic unfavorable (6.93e-4)" "unprognostic (2.58e-3)" "unprognostic (3.86e-2)" 11.3 19.6 6.2 12.8 6.6 7.7 9.9 6.1 7.9 12.4 12.7 18.8 15.8 11.0 14.5 11.2 12.4 9.8 8.3 6.5 6.6 12.6 21.0 9.3 12.4 6.3 6.0 8.8 26.8 17.5 10.9 9.5 6.9 10.5 16.3 6.8 18.8 10.6 7.4 8.8 13.1 12.0 5.8 15.0 19.6 20.8 6.5 12.0 11.6 5.5 12.1 12.4 8.3 6.8 24.0 53.7 10.8 25.5 40.7 24.2 26.4 50.6 50.6 46.9 46.4 44.8 72.4 44.4 43.1 48.0 20.7 58.2 30.1 36.2 31.6 42.0 43.3 20.7 40.1 87.1 33.4 37.6 37.3 29.7 26.9 36.2 23.0 18.5 28.7 32.2 29.5 44.7 34.5 50.1 28.9 40.7 51.2 31.7 33.6 48.8 16.0 124.9 28.3 18.7 20.7 21.7 49.3 67.8 27.4 14.3 45.1 29.2 29.8 22.5 25.6 134.7 40.1 39.8 59.3 30.2 20.5 39.8 38.1 11.5 79.9 28.8 87.2 80.6 77.1 72.9 74.9 86.3 86.7 73.9 66.7 75.0 4.3 79.8 80.0 75.6 81.1 126.6 6.2 6.6 6.1 7.9 6.5 6.6 6.3 6.0 6.9 5.8 6.5 6.8 4.6 16.0 6.1 4.2 11.2 2.4 3.4 15.7 5.2 7.4 6.8 6.0 0.7 8.6 14.3 7.3 12.5 16.2 7.2 8.5 3.9 19.5 10.7 5.4 8.1 8.7 13.3 12.0 4.0 28.3 18.7 9.3 13.7 5.5 1.3 8.1 8.6 17.7 21.7 3.3 4.6 21.0 8.2 10.6 2.4 25.5 9.6 7.6 10.6 1.0 9.3 7.5 9.2 3.5 3.4 21.6 11.1 6.8 22.7 4.5 11.8 10.4 11.7 6.3 6.6 5.4 7.1 28.0 16.0 7.7 1.6 8.5 8.6 13.8 18.0 4.4 ALG10 "ALG10A, DIE2, FLJ14751" ENSG00000139133 "ALG10 alpha-1,2-glucosyltransferase" Q5BKT4 12 34022468-34029694 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Spermatocytes: 12.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "HPA043329, HPA063387" Approved Approved "Endoplasmic reticulum" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 34: Non-specific - Transcription" "Cluster 5: NTERA-2 - Transcription" "Cluster 12: Non-specific - Cell cycle regulation" "Endoplasmic reticulum" "HPA043329: AB_2678432, HPA063387: AB_2685000" "unprognostic (1.71e-1)" "unprognostic (4.98e-2)" "unprognostic (3.16e-3)" "unprognostic (2.80e-2)" "unprognostic (9.23e-2)" "unprognostic (3.49e-2)" "unprognostic (5.88e-4)" "unprognostic (2.13e-1)" "unprognostic (1.73e-2)" "unprognostic (8.01e-2)" "unprognostic (5.41e-2)" "unprognostic (1.16e-1)" "unprognostic (9.29e-2)" "unprognostic (8.99e-2)" "unprognostic (1.53e-1)" "unprognostic (2.43e-1)" "unprognostic (6.45e-2)" 2.3 2.6 1.3 2.7 1.5 4.1 2.8 1.7 1.1 1.9 0.9 2.3 1.6 2.2 2.7 2.1 3.4 1.8 1.0 0.8 1.5 1.9 2.9 1.8 3.7 1.9 1.2 2.3 1.5 2.3 0.6 2.3 1.6 2.6 1.9 3.3 1.5 1.9 0.9 1.9 1.8 2.1 1.6 2.9 2.0 2.6 1.3 3.6 2.8 1.3 2.9 1.3 0.9 2.2 5.3 5.8 4.0 7.0 4.6 4.3 14.0 5.1 4.7 5.4 9.8 8.8 12.6 10.3 7.3 2.6 8.2 7.8 7.9 6.8 7.9 13.0 7.2 9.2 6.7 3.9 1.8 11.4 8.1 4.0 3.6 11.3 9.3 2.6 3.7 8.1 13.9 13.6 5.5 6.8 8.4 6.3 15.1 3.2 7.7 6.5 14.8 8.3 3.2 7.8 3.8 3.0 9.4 3.8 5.6 11.7 8.6 3.2 7.5 7.4 10.7 11.3 6.5 7.4 14.7 17.3 5.0 4.8 6.2 0.0 1.0 1.7 0.6 0.4 0.9 0.8 0.9 0.4 0.6 0.8 1.1 1.3 0.1 0.8 0.5 0.7 1.2 0.5 1.3 1.5 1.7 1.1 0.8 1.5 1.9 1.2 1.6 1.6 1.3 2.2 3.0 6.4 0.5 1.3 5.1 1.5 3.0 4.3 2.8 4.6 2.0 1.7 0.8 2.8 5.1 5.5 4.2 6.8 3.5 1.4 1.9 2.4 1.0 3.1 2.8 2.3 1.2 7.0 1.5 3.8 5.5 2.7 3.1 2.2 1.3 3.6 0.7 2.9 3.3 1.7 1.8 1.7 2.0 2.8 1.9 0.3 1.5 2.2 0.0 1.9 3.3 3.4 1.0 2.5 1.8 3.3 0.6 1.2 4.0 0.8 1.2 1.3 3.9 4.2 0.0 2.5 2.0 12.4 5.8 4.3 2.7 3.1 3.2 2.6 1.9 1.8 ALG10B KCR1 ENSG00000175548 "ALG10 alpha-1,2-glucosyltransferase B" Q5I7T1 12 38316762-38329721 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 33.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "HPA043329, HPA063387" Approved Approved "Endoplasmic reticulum" NA NA "Cluster 24: B-cells - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 20: HeLa - Mitochondria" "Cluster 52: Non-specific - Transcription" "Endoplasmic reticulum" "HPA043329: AB_2678432, HPA063387: AB_2685000" "unprognostic (4.55e-2)" "unprognostic (1.01e-1)" "unprognostic (2.32e-1)" "unprognostic (1.25e-1)" "unprognostic (1.79e-1)" "unprognostic (3.01e-1)" "unprognostic (4.43e-2)" "unprognostic (8.58e-2)" "unprognostic (7.40e-2)" "unprognostic (8.40e-2)" "unprognostic (1.17e-1)" "unprognostic (2.05e-2)" "unprognostic (1.91e-1)" "unprognostic (3.30e-3)" "unprognostic (2.63e-1)" "unprognostic (1.93e-1)" "unprognostic (2.28e-1)" 2.9 3.5 2.1 3.0 2.3 4.3 5.2 3.1 2.5 2.8 1.8 2.1 2.4 3.7 3.7 1.8 3.4 2.6 2.2 1.8 2.0 3.3 3.7 2.5 4.6 2.5 2.3 5.0 2.9 3.7 1.1 5.0 2.6 3.4 2.6 9.1 2.8 2.2 1.5 4.3 2.6 2.5 2.6 4.6 3.7 2.6 2.2 4.0 4.2 2.4 3.7 1.5 1.4 3.1 5.1 4.6 6.1 6.2 3.0 5.5 6.3 4.0 2.0 5.3 4.6 1.7 15.2 8.0 7.2 2.3 4.1 5.3 5.7 4.4 7.6 5.2 6.8 8.4 8.4 3.5 3.5 11.3 6.1 3.1 5.7 7.5 5.5 4.7 4.2 10.4 9.6 4.6 4.8 3.9 7.5 8.9 7.8 0.5 4.6 2.5 13.2 6.3 4.4 6.4 1.8 6.3 7.1 2.3 5.0 6.6 10.6 4.6 3.3 5.5 6.6 4.9 5.2 3.6 10.1 12.5 4.7 7.7 7.3 0.3 0.4 0.6 0.3 0.5 0.5 0.4 0.3 0.4 0.3 1.3 0.5 0.7 0.1 0.4 0.4 0.7 1.2 0.3 2.1 2.3 3.1 2.5 1.8 2.0 2.5 2.3 2.6 2.6 2.2 3.1 7.1 6.4 13.9 9.1 2.6 2.0 3.4 3.3 4.0 14.9 5.0 3.8 3.9 0.0 7.0 3.7 33.3 16.1 2.1 0.9 7.9 4.3 0.3 6.5 6.2 5.7 0.0 2.5 4.8 5.8 9.6 4.8 2.0 4.6 1.3 9.5 6.8 7.1 4.8 10.1 5.7 1.9 4.1 1.6 2.0 1.8 4.1 3.1 1.8 10.3 2.5 8.0 1.0 9.0 9.1 4.5 2.0 5.7 1.6 2.0 2.6 2.6 5.2 14.5 6.6 6.5 3.2 10.7 4.7 3.1 1.8 8.1 3.0 4.6 2.3 2.3 ALG11 "CDG1P, KIAA0266" ENSG00000253710 "ALG11 alpha-1,2-mannosyltransferase" Q2TAA5 13 52012391-52079232 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Congenital disorder of glycosylation, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA047214 Approved NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 1: Thyroid gland - Transcription" "Cluster 3: HMC-1 - Innate immune response" "Cluster 59: Non-specific - Transcription" "HPA047214: AB_10961640" "unprognostic (9.21e-2)" "unprognostic (1.31e-3)" "unprognostic (2.02e-1)" "unprognostic (4.18e-2)" "unprognostic (2.21e-2)" "unprognostic (3.04e-2)" "unprognostic (9.15e-3)" "unprognostic (1.69e-1)" "unprognostic (2.28e-1)" "unprognostic (8.97e-3)" "unprognostic (8.89e-3)" "unprognostic (7.47e-2)" "unprognostic (2.30e-4)" "unprognostic (1.87e-2)" "unprognostic (1.60e-1)" "unprognostic (6.03e-2)" "unprognostic (9.71e-3)" 10.1 9.5 7.4 8.3 8.4 4.1 12.1 9.5 9.7 12.1 1.9 11.0 10.1 11.0 9.4 7.5 10.8 8.9 10.4 7.5 4.8 14.6 19.2 9.1 8.1 4.8 4.0 11.6 8.6 17.2 2.4 12.7 4.6 12.1 11.8 9.0 10.9 10.9 6.5 7.2 9.7 11.4 2.9 10.1 11.6 6.2 4.7 9.5 16.8 8.8 8.6 8.7 2.5 9.6 6.7 10.5 17.8 15.2 18.6 13.3 14.2 17.7 16.3 12.9 10.3 8.5 14.5 16.2 4.2 18.4 15.8 15.3 18.2 12.0 17.0 16.7 12.9 31.0 8.8 11.4 14.1 28.3 31.0 12.9 17.8 10.1 18.4 14.1 11.5 18.5 17.8 10.4 19.4 5.7 14.7 9.7 19.2 28.8 7.5 15.2 11.9 8.9 16.7 10.8 6.9 15.2 11.9 17.1 11.9 15.0 11.9 20.8 17.8 10.4 11.5 13.6 11.8 9.1 13.5 17.7 6.4 11.7 18.0 13.2 5.4 7.2 7.7 4.5 7.6 5.1 7.0 6.6 6.9 7.1 8.9 8.9 2.2 7.3 12.0 9.8 7.2 4.9 7.4 8.4 9.5 9.7 7.5 4.8 4.8 4.0 4.6 2.9 4.7 9.6 5.3 19.2 8.2 5.5 7.1 2.4 3.2 7.8 8.0 6.8 4.2 3.2 7.5 5.7 9.3 3.7 6.2 3.4 6.2 2.1 1.9 2.9 0.9 5.1 7.3 5.2 3.0 12.6 9.3 2.2 3.9 8.2 9.7 5.4 3.8 6.5 6.1 4.0 2.5 5.0 8.1 2.7 6.1 2.2 3.1 0.5 3.4 3.5 1.8 5.6 2.6 2.8 11.3 13.0 8.9 2.7 1.7 1.2 14.0 2.6 3.5 1.7 13.5 7.5 0.0 4.2 6.4 4.8 3.5 7.8 2.4 4.8 7.2 3.7 2.1 4.0 ALG12 "CDG1G, ECM39" ENSG00000182858 "ALG12 alpha-1,6-mannosyltransferase" Q9BV10 22 49900229-49918438 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Congenital disorder of glycosylation, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003076, HPA051665" Approved Approved "Endoplasmic reticulum" NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 18: Non-specific - Mitochondria" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Endoplasmic reticulum" "HPA003076: AB_2666777, HPA051665: AB_2681566" "unprognostic (1.66e-1)" "unprognostic (1.26e-1)" "unprognostic (4.39e-3)" "prognostic favorable (6.09e-4)" "unprognostic (2.29e-1)" "unprognostic (3.32e-2)" "unprognostic (4.27e-3)" "unprognostic (3.33e-2)" "unprognostic (1.46e-1)" "unprognostic (3.32e-2)" "unprognostic (1.42e-1)" "unprognostic (2.21e-1)" "prognostic favorable (3.60e-5)" "unprognostic (1.62e-2)" "unprognostic (3.00e-2)" "unprognostic (9.89e-3)" "unprognostic (6.32e-2)" 6.3 8.0 3.5 7.3 4.5 5.9 6.4 6.2 4.7 7.6 4.9 8.8 11.1 8.3 6.5 8.0 7.6 6.6 8.3 3.9 2.6 10.3 14.5 7.0 5.6 4.5 4.3 7.1 11.4 11.8 6.6 5.4 4.7 9.1 4.1 3.0 12.0 5.6 6.1 7.2 8.9 4.4 3.3 7.2 10.3 4.5 4.9 6.5 11.7 4.5 4.8 7.7 6.8 8.4 8.6 8.5 8.8 14.7 16.4 7.6 9.8 8.8 7.9 10.2 8.2 14.0 12.0 4.6 7.8 7.8 11.1 15.2 10.7 10.4 5.0 7.3 15.9 4.2 14.7 14.1 18.6 10.6 8.9 11.6 10.5 9.9 14.3 11.2 9.9 10.3 5.3 11.2 5.4 19.6 10.4 8.6 8.4 11.3 7.7 17.2 11.0 12.1 10.6 9.6 5.9 9.6 14.0 26.3 11.4 11.7 10.8 9.4 7.7 11.2 8.5 7.9 6.8 9.8 4.9 6.1 12.5 8.0 10.9 21.4 8.7 7.7 11.5 8.5 11.7 4.8 8.9 11.4 7.6 6.4 7.3 8.6 7.1 16.9 10.1 7.7 12.8 8.1 3.5 4.5 6.2 4.7 3.9 2.6 4.5 4.3 4.7 3.3 4.9 8.4 6.8 9.6 3.1 21.5 10.2 4.1 10.2 12.1 9.1 5.2 11.1 10.2 1.2 8.6 10.3 18.4 2.1 20.5 8.5 16.6 3.9 15.9 6.9 6.6 8.0 8.1 6.7 7.4 23.2 13.5 22.4 10.6 11.7 9.2 8.2 7.0 5.3 15.0 18.6 3.3 30.4 12.9 12.2 9.2 5.3 4.3 8.7 8.7 10.6 9.4 9.0 2.9 18.6 17.6 40.4 10.3 9.7 8.2 15.6 11.3 18.8 6.8 5.6 5.2 0.0 8.5 7.7 12.9 9.1 10.4 6.0 26.3 11.9 8.3 16.3 9.1 ALG13 "CDG1S, CXorf45, FLJ23018, GLT28D1, MDS031, TDRD13, YGL047W" ENSG00000101901 "ALG13 UDP-N-acetylglucosaminyltransferase subunit" Q9NP73 X 111665811-111760649 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "Glycosyltransferase, Hydrolase, Multifunctional enzyme, Protease, Thiol protease, Transferase" "Congenital disorder of glycosylation, Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002853, HPA005498" Approved Approved Vesicles,Cytosol NA NA 11000000 "Cluster 34: Basophils - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 2: Karpas-707 - Immune response" "Cluster 24: Non-specific - Transcription regulation" Vesicles Cytosol "HPA002853: AB_1078131, HPA005498: " "unprognostic (4.13e-1)" "unprognostic (1.80e-1)" "unprognostic (2.45e-2)" "unprognostic (1.51e-1)" "unprognostic (6.97e-2)" "unprognostic (6.14e-2)" "unprognostic (2.74e-1)" "unprognostic (6.55e-3)" "unprognostic (2.26e-2)" "unprognostic (3.39e-3)" "unprognostic (1.73e-2)" "unprognostic (4.62e-3)" "prognostic unfavorable (1.10e-6)" "unprognostic (1.19e-1)" "unprognostic (1.29e-2)" "unprognostic (9.70e-2)" "unprognostic (2.45e-2)" 15.1 17.9 10.5 18.8 11.7 16.6 18.3 11.5 19.0 17.2 12.3 18.2 13.7 16.1 20.5 14.7 15.4 16.4 13.2 10.2 13.8 21.0 23.8 13.8 23.4 12.6 12.1 15.8 14.7 23.4 17.9 14.1 13.3 17.7 19.4 11.8 15.6 13.4 9.2 19.4 17.3 17.5 11.4 18.5 15.5 17.4 11.8 17.3 18.2 9.9 20.1 21.3 14.7 16.6 22.3 24.4 21.8 13.8 13.8 19.6 12.3 17.7 18.3 22.4 27.5 24.9 23.1 19.5 33.0 24.7 46.5 12.6 26.1 12.5 23.5 14.4 17.6 10.7 26.1 28.4 20.3 19.5 40.5 23.6 22.8 18.0 38.6 23.3 24.8 21.8 23.9 53.5 22.5 55.8 16.4 17.6 19.9 66.3 33.6 12.8 13.9 26.7 36.6 34.0 13.1 19.1 25.2 15.2 16.3 21.7 13.6 18.5 16.7 19.2 9.7 24.9 34.4 25.8 47.1 31.5 20.5 25.5 15.2 39.5 15.8 16.6 9.5 16.3 9.3 10.6 10.6 9.2 18.5 12.1 13.0 10.8 3.0 4.6 12.9 9.5 14.6 9.6 10.5 11.7 11.5 19.0 10.2 13.8 12.6 12.1 13.3 11.4 11.8 16.6 50.9 16.0 30.8 33.6 127.9 35.2 65.8 53.5 33.6 15.1 33.9 31.6 18.7 22.8 36.0 18.4 10.4 27.3 73.9 39.2 45.0 37.4 21.1 48.2 31.1 37.4 26.5 27.1 64.7 52.1 39.1 34.6 37.2 47.9 109.8 15.7 28.2 28.4 42.5 11.8 57.4 49.0 46.8 39.2 52.3 9.4 21.5 56.1 28.4 83.4 41.8 16.0 29.9 41.7 77.5 58.0 55.6 16.1 60.4 46.9 38.5 55.5 35.3 16.5 26.3 38.7 46.2 32.6 22.4 26.5 35.4 48.7 71.1 28.8 32.8 64.6 ALG2 "CDG1I, CDGIi, FLJ14511, hALPG2, NET38" ENSG00000119523 "ALG2 alpha-1,3/1,6-mannosyltransferase" Q9H553 9 99216425-99221942 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Congenital disorder of glycosylation, Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041512, HPA041601" Approved Approved "Golgi apparatus" NA No "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 29: Non-specific - Vesicular transport" "Cluster 30: Epithelial cell lines - Translation" "Cluster 55: Plasma cells - Humoral immune response" "Golgi apparatus" "HPA041512: AB_10794380, HPA041601: AB_10794302" "unprognostic (8.86e-3)" "unprognostic (4.39e-1)" "unprognostic (2.37e-1)" "prognostic favorable (8.44e-5)" "unprognostic (9.21e-3)" "prognostic unfavorable (1.56e-4)" "unprognostic (1.06e-2)" "unprognostic (5.94e-2)" "unprognostic (3.31e-1)" "unprognostic (3.66e-1)" "unprognostic (2.99e-2)" "unprognostic (1.08e-1)" "prognostic favorable (2.28e-7)" "unprognostic (4.16e-2)" "unprognostic (1.73e-1)" "unprognostic (3.10e-2)" "unprognostic (4.81e-1)" 17.7 38.2 13.4 19.4 14.6 23.0 27.1 16.6 18.4 35.1 19.8 24.9 21.9 23.8 74.0 15.1 29.5 26.2 13.4 14.5 15.0 34.3 47.4 24.3 20.8 14.7 16.1 30.2 42.0 37.0 21.8 29.9 15.1 32.8 27.3 15.0 37.9 34.5 15.3 17.9 20.5 24.2 14.8 17.9 25.0 19.2 14.7 16.7 42.3 13.5 27.5 31.7 10.9 16.9 22.9 28.7 22.7 34.4 82.6 52.7 42.0 46.7 75.3 45.6 39.3 34.9 31.2 24.6 18.8 54.3 60.0 85.3 37.9 49.1 45.7 35.2 16.2 14.4 23.7 54.0 99.7 28.2 26.2 61.9 65.2 37.7 72.8 45.8 52.3 15.1 23.2 56.2 44.7 47.8 12.9 29.8 27.6 75.0 39.6 14.0 43.4 38.1 65.2 31.1 22.5 19.3 33.5 63.8 61.6 33.5 24.4 23.3 38.8 31.4 27.9 40.9 28.6 45.8 28.0 10.5 58.6 20.5 16.3 38.7 35.5 22.0 33.7 28.2 49.2 30.8 32.0 33.9 45.1 26.3 27.7 27.4 9.3 38.0 28.4 79.9 38.3 36.0 13.4 14.6 16.6 18.4 14.5 15.0 14.7 16.1 15.1 14.8 14.7 16.9 12.6 12.8 22.9 6.8 22.1 23.3 26.8 56.2 10.2 11.3 22.6 16.6 6.9 32.9 35.8 23.9 2.1 50.3 30.2 20.0 21.5 36.1 28.7 16.9 30.9 19.8 12.5 12.0 8.1 35.2 34.2 30.4 15.3 26.4 7.6 14.1 21.8 55.5 28.1 10.1 8.3 26.3 38.7 25.8 45.4 20.3 26.8 23.0 21.4 10.3 64.2 15.5 15.5 9.5 9.7 31.9 16.0 25.2 47.0 37.3 18.7 36.6 33.1 8.3 6.6 17.2 18.2 22.6 24.6 15.0 23.7 89.2 16.6 25.6 20.8 31.3 ALG3 "CDGS4, D16Ertd36e, Not56, NOT56L" ENSG00000214160 "ALG3 alpha-1,3- mannosyltransferase" Q92685 3 184242301-184249548 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Congenital disorder of glycosylation, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 211.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA045103 Enhanced NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 29: Non-specific - Vesicular transport" "Cluster 25: RPMI-8226 - Immune response" "Cluster 55: Plasma cells - Humoral immune response" "HPA045103: AB_10960547" "unprognostic (3.63e-2)" "unprognostic (2.60e-1)" "unprognostic (2.36e-2)" "unprognostic (1.80e-3)" "unprognostic (3.63e-1)" "unprognostic (7.93e-3)" "prognostic unfavorable (1.58e-5)" "prognostic unfavorable (8.67e-5)" "unprognostic (6.18e-2)" "unprognostic (1.24e-1)" "unprognostic (4.19e-3)" "unprognostic (6.15e-2)" "prognostic unfavorable (1.25e-4)" "unprognostic (9.35e-2)" "unprognostic (1.03e-1)" "unprognostic (2.64e-1)" "unprognostic (5.02e-2)" 22.0 32.6 9.3 15.0 9.3 15.7 19.7 10.8 11.1 18.1 13.9 23.8 16.9 17.5 12.5 30.5 15.1 11.6 19.6 8.8 9.7 18.7 58.0 18.1 13.0 10.6 10.1 12.7 37.1 23.1 14.6 19.6 11.2 19.8 18.3 6.0 26.8 13.7 30.2 24.9 20.4 16.4 10.0 20.8 23.1 25.7 10.7 12.2 18.4 14.8 14.1 22.5 19.8 10.3 77.2 67.6 18.0 59.5 70.2 39.4 59.3 40.6 46.0 54.9 47.3 102.8 50.9 67.6 108.4 50.8 112.0 90.8 64.1 90.0 34.5 49.0 76.7 60.8 49.3 84.7 64.3 99.5 52.4 47.0 74.7 64.8 90.9 29.4 30.0 46.0 60.7 132.6 36.1 95.8 48.5 83.1 55.9 153.3 85.8 49.9 27.5 269.7 63.2 25.7 44.3 36.7 37.6 147.0 67.5 21.8 140.2 54.8 24.3 57.2 36.0 51.2 88.4 72.3 137.8 71.3 51.5 129.2 52.9 0.6 60.9 14.6 35.8 61.1 40.5 31.6 38.3 36.8 71.4 30.8 33.9 33.2 2.0 48.9 51.3 65.3 44.6 41.7 9.3 9.3 10.8 11.1 8.8 9.7 10.6 10.1 11.2 10.0 10.7 10.3 14.2 6.4 18.1 4.6 24.5 25.0 28.3 61.0 26.2 10.4 24.1 20.8 11.7 21.5 43.0 20.2 10.4 79.2 21.0 24.9 7.9 62.3 95.7 9.1 17.7 18.7 14.5 24.4 5.6 63.1 100.4 22.3 25.0 13.5 12.7 16.3 12.5 51.7 69.8 8.4 5.9 33.3 50.8 24.9 15.5 211.5 12.5 25.8 21.4 7.5 21.2 13.7 16.5 7.1 6.3 44.6 22.0 15.1 63.8 47.2 39.4 31.8 16.7 13.0 19.7 9.0 34.6 29.7 34.3 39.4 27.0 65.8 17.6 23.1 45.6 29.1 ALG5 bA421P11.2 ENSG00000120697 "ALG5 dolichyl-phosphate beta-glucosyltransferase" Q9Y673 13 36949738-37000763 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007989 Approved Approved Cytosol No No "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 21: OE19 - Mitochondria" "Cluster 55: Plasma cells - Humoral immune response" Cytosol "HPA007989: AB_1078132" "unprognostic (1.87e-1)" "unprognostic (1.73e-2)" "unprognostic (6.07e-2)" "unprognostic (1.05e-3)" "unprognostic (3.01e-1)" "prognostic unfavorable (2.11e-4)" "unprognostic (1.57e-2)" "unprognostic (5.82e-2)" "unprognostic (5.21e-2)" "unprognostic (7.46e-2)" "unprognostic (3.51e-2)" "unprognostic (3.30e-1)" "prognostic favorable (1.40e-5)" "unprognostic (7.44e-2)" "unprognostic (1.66e-1)" "unprognostic (7.14e-3)" "unprognostic (1.86e-1)" 29.1 32.3 12.1 19.6 13.3 26.9 41.6 13.4 25.7 34.2 14.9 36.0 27.1 23.5 77.9 21.7 23.3 23.2 18.5 12.4 13.7 41.2 61.9 24.5 20.7 13.5 13.1 20.6 90.1 40.2 18.7 25.4 14.0 26.5 46.4 11.2 51.9 30.9 18.5 20.9 27.6 23.4 13.6 23.6 36.6 15.2 12.6 22.7 54.9 10.5 28.9 30.5 21.6 14.8 24.3 35.0 31.5 29.4 95.1 61.8 22.5 63.9 81.1 63.7 53.7 71.0 84.1 35.2 25.9 45.7 55.0 57.5 41.9 55.0 62.6 37.4 77.7 77.2 27.5 40.1 85.1 69.6 43.7 62.7 88.8 49.4 60.6 41.5 47.7 43.9 39.8 49.7 59.9 45.6 47.4 59.8 29.1 188.2 27.5 54.3 30.4 102.5 71.5 49.8 25.2 45.5 29.2 62.8 34.2 25.4 34.4 79.1 36.1 32.7 20.4 37.2 45.8 35.8 28.8 37.4 51.2 41.9 57.1 59.1 55.7 26.2 53.4 62.3 54.4 44.1 49.1 55.6 57.1 40.2 46.4 47.2 5.8 54.7 53.0 109.0 65.7 69.2 12.1 13.3 13.4 25.7 12.4 13.7 13.5 13.1 14.0 13.6 12.6 14.8 52.0 51.3 51.9 11.1 51.5 34.7 45.9 142.9 27.3 19.8 50.2 42.5 14.2 61.5 86.0 53.3 10.4 81.4 49.4 28.9 23.5 93.5 33.7 31.5 44.1 45.5 36.1 25.9 19.5 140.2 74.4 46.0 32.1 40.1 29.2 25.9 37.9 77.3 69.7 11.8 22.4 76.3 111.9 37.1 52.1 25.8 40.0 39.4 80.0 14.0 45.2 36.6 25.7 18.1 30.6 85.9 50.9 38.4 166.6 56.4 51.4 62.7 43.8 25.2 46.0 34.4 70.7 57.6 23.7 33.6 30.3 81.3 43.0 58.5 62.2 50.7 ALG6 ENSG00000088035 "ALG6 alpha-1,3-glucosyltransferase" Q9Y672 1 63367575-63438553 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Congenital disorder of glycosylation, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "NTERA-2: 7.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA062536, HPA076130" Approved Approved "Endoplasmic reticulum" NA NA "Cluster 10: Basophils - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 5: NTERA-2 - Transcription" "Cluster 47: Cytotrophoblasts - Unknown function" "Endoplasmic reticulum" "HPA062536: AB_2684792, HPA076130: " "unprognostic (1.21e-1)" "unprognostic (5.60e-3)" "prognostic favorable (4.86e-4)" "unprognostic (1.59e-1)" "unprognostic (3.45e-1)" "unprognostic (2.45e-2)" "prognostic unfavorable (9.46e-4)" "unprognostic (2.07e-1)" "unprognostic (9.81e-3)" "unprognostic (4.65e-2)" "unprognostic (2.00e-2)" "unprognostic (3.90e-2)" "prognostic unfavorable (2.63e-6)" "unprognostic (1.84e-3)" "unprognostic (1.07e-1)" "unprognostic (4.61e-2)" "unprognostic (3.41e-1)" 3.5 4.5 1.1 1.1 1.3 1.4 3.4 1.9 1.4 3.7 1.0 3.8 1.1 2.9 1.4 6.1 3.0 0.8 2.1 1.1 1.2 3.0 4.6 2.7 1.9 1.1 1.2 3.2 3.3 1.4 2.0 1.0 1.1 3.1 1.2 1.2 4.3 0.6 2.8 5.1 4.4 0.6 1.1 5.2 3.2 2.2 1.1 2.0 3.1 0.1 1.6 3.1 4.2 1.4 0.5 1.3 1.3 1.2 1.8 1.3 2.6 0.9 0.2 0.3 0.3 2.0 0.6 2.7 1.4 0.7 1.5 1.0 2.0 1.0 1.4 2.4 4.2 2.2 1.5 2.4 0.6 2.8 2.4 0.9 0.6 0.9 0.6 0.7 2.0 2.3 2.2 1.3 1.0 2.5 1.7 2.4 7.6 1.3 2.3 1.8 1.6 2.1 1.6 2.2 1.5 0.8 2.3 3.2 2.3 2.9 0.9 2.1 0.9 0.6 0.6 1.8 1.5 1.7 1.7 1.7 1.2 3.3 2.4 1.3 0.3 0.4 0.3 0.3 0.4 0.3 0.3 0.2 0.3 0.3 0.6 0.5 0.1 0.4 0.3 0.2 0.3 0.2 1.1 1.3 1.9 1.4 1.1 1.2 1.1 1.2 1.1 1.1 1.1 1.4 9.8 9.6 4.8 9.8 12.1 11.0 8.5 24.6 15.4 6.3 8.5 5.5 3.1 12.8 22.1 3.7 4.2 42.1 10.2 6.1 1.9 12.4 2.4 11.2 7.0 8.7 4.2 9.0 19.1 8.9 28.5 8.6 11.2 10.0 8.9 12.2 8.2 11.5 15.5 6.7 19.4 7.8 22.4 7.1 8.8 2.0 6.8 9.1 16.0 4.7 4.8 5.5 13.4 19.1 16.8 6.0 3.6 4.9 11.4 4.9 8.2 7.3 11.7 5.4 6.6 4.5 6.6 16.2 15.3 18.3 11.1 26.8 15.1 10.0 11.5 7.4 ALG8 MGC2840 ENSG00000159063 "ALG8 alpha-1,3-glucosyltransferase" Q9BVK2 11 78095244-78139660 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Congenital disorder of glycosylation, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Spermatocytes: 105.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA051898 Approved Approved Nucleoplasm NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 23: Testis - Cell cycle regulation" "Cluster 21: OE19 - Mitochondria" "Cluster 55: Plasma cells - Humoral immune response" Nucleoplasm "HPA051898: AB_2681656" "unprognostic (1.37e-1)" "unprognostic (9.24e-2)" "unprognostic (4.60e-2)" "unprognostic (2.69e-2)" "unprognostic (2.65e-1)" "unprognostic (6.49e-2)" "unprognostic (5.38e-3)" "unprognostic (5.91e-2)" "unprognostic (1.39e-1)" "unprognostic (1.10e-3)" "unprognostic (5.29e-2)" "unprognostic (1.20e-1)" "unprognostic (1.35e-2)" "unprognostic (1.19e-1)" "unprognostic (2.34e-1)" "unprognostic (3.78e-2)" "unprognostic (6.37e-2)" 22.8 33.0 12.7 13.4 14.3 9.2 25.6 13.9 16.4 18.7 15.4 17.5 13.3 15.9 33.2 19.0 18.8 12.0 17.9 12.9 13.3 24.9 47.1 15.0 14.6 14.1 13.1 22.1 23.8 23.7 19.8 18.7 13.8 19.1 21.8 10.4 21.7 18.0 12.1 16.6 15.5 16.4 13.5 18.3 20.2 43.5 13.1 17.8 22.4 8.9 19.8 18.4 16.0 15.2 27.8 74.4 62.8 56.6 63.7 42.5 37.6 38.6 57.8 68.6 67.4 127.9 102.0 61.4 74.5 51.5 92.3 86.5 87.0 56.5 111.9 46.3 50.8 74.3 56.5 62.2 38.9 71.8 39.6 34.4 36.4 81.8 37.9 37.5 50.3 58.0 98.2 65.8 97.7 38.6 53.3 61.9 81.9 200.5 38.1 63.6 32.6 168.3 70.0 40.4 20.2 44.8 62.0 102.2 29.4 65.6 106.5 50.8 32.0 43.5 50.6 102.5 35.1 46.6 88.0 80.3 26.7 71.4 84.4 1.2 30.0 5.4 25.1 34.5 29.1 37.2 25.5 25.7 34.2 31.3 29.7 26.2 2.6 29.1 39.9 33.1 22.5 27.6 12.7 14.3 13.9 16.4 12.9 13.3 14.1 13.1 13.8 13.5 13.1 15.2 11.9 12.8 11.6 12.4 21.0 10.5 23.3 49.6 26.2 14.7 18.3 16.3 6.9 20.0 35.2 20.2 18.8 53.8 9.1 7.0 5.9 24.4 18.9 11.0 16.9 17.2 7.8 9.9 21.3 25.4 59.5 19.4 11.7 13.8 11.4 36.4 9.3 40.2 31.4 16.8 18.0 15.9 32.6 17.0 10.8 14.0 18.0 15.3 26.6 12.2 12.3 8.2 21.6 13.0 20.7 17.7 6.4 15.8 43.1 16.9 7.7 15.8 21.7 13.5 0.0 14.2 19.6 105.0 37.8 20.9 8.9 32.7 15.2 16.9 16.8 15.2 ALG9 DIBD1 ENSG00000086848 "ALG9 alpha-1,2-mannosyltransferase" Q9H6U8 11 111782195-111871581 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Congenital disorder of glycosylation, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 26.6;Inhibitory neurons: 31.8;Oligodendrocytes: 31.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" HPA038575 Approved Approved "Endoplasmic reticulum" NA NA "Cluster 10: Basophils - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 25: RPMI-8226 - Immune response" "Cluster 59: Non-specific - Transcription" "Endoplasmic reticulum" "HPA038575: AB_10672718" "unprognostic (1.48e-1)" "unprognostic (5.39e-2)" "unprognostic (6.22e-2)" "unprognostic (5.34e-3)" "unprognostic (8.72e-2)" "unprognostic (2.90e-1)" "unprognostic (2.43e-2)" "unprognostic (1.04e-2)" "unprognostic (7.07e-3)" "unprognostic (5.11e-2)" "unprognostic (8.75e-3)" "unprognostic (1.52e-2)" "prognostic unfavorable (7.29e-5)" "unprognostic (9.15e-2)" "unprognostic (7.76e-2)" "unprognostic (4.20e-2)" "unprognostic (1.10e-2)" 14.0 9.7 6.3 8.6 7.1 7.8 12.4 8.2 7.8 12.9 6.3 10.9 12.1 11.5 10.9 11.4 9.2 7.9 10.1 6.3 6.6 9.5 13.4 9.6 6.6 6.5 6.8 12.5 19.7 12.7 10.0 9.6 6.7 9.6 10.3 12.0 17.5 11.3 9.1 15.2 10.2 11.1 5.6 8.4 12.0 13.6 6.1 9.8 12.3 8.3 9.2 11.3 11.1 6.4 16.6 16.5 30.7 31.1 19.0 18.0 23.7 20.5 16.5 16.4 17.9 28.7 27.4 27.1 28.7 23.8 21.4 29.8 16.6 25.4 23.4 20.2 12.2 19.7 8.6 21.2 22.0 22.2 13.6 15.5 17.2 17.7 17.8 24.2 16.2 20.2 20.3 41.0 28.4 12.5 22.2 20.3 10.7 23.3 15.9 20.4 26.9 51.5 18.5 13.7 15.0 25.4 18.0 28.0 11.4 21.6 29.0 9.3 16.9 35.0 25.2 17.1 22.6 13.3 10.2 24.4 15.1 27.4 24.7 4.5 3.1 3.8 4.0 4.5 4.7 4.0 4.1 4.6 5.2 3.1 5.8 3.6 1.1 4.2 4.0 5.6 4.5 3.3 6.3 7.1 8.2 7.8 6.3 6.6 6.5 6.8 6.7 5.6 6.1 6.4 3.2 0.0 4.4 21.5 5.9 2.0 1.5 3.2 9.6 8.9 3.8 3.4 5.6 1.5 3.9 7.3 8.4 3.5 4.6 3.2 3.9 7.5 5.1 2.0 5.2 4.1 4.2 6.3 26.6 7.1 12.6 4.7 4.6 3.8 0.0 5.5 2.2 6.8 3.2 15.2 31.8 4.0 4.1 1.9 1.9 4.3 4.7 3.5 0.0 12.2 3.1 4.9 3.1 21.1 31.8 6.5 2.9 3.8 22.8 1.3 4.6 2.3 2.2 9.7 6.6 3.5 5.4 4.2 5.7 8.6 1.6 9.0 5.8 2.5 4.4 0.8 ALK CD246 ENSG00000171094 "ALK receptor tyrosine kinase" Q9UM73 2 29192774-29921586 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 8 "brain: 10.9" "Group enriched" "Detected in some" 5 "Inhibitory neurons: 274.2;Oligodendrocyte precursor cells: 433.8" "Group enriched" "Detected in some" 5 "glioma: 1.0;melanoma: 1.5;ovarian cancer: 0.7;thyroid cancer: 1.3" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 6 "SH-SY5Y: 31.7" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA010694 Approved Supported "Plasma membrane" NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Plasma membrane" "HPA010694: AB_1078133" "unprognostic (4.96e-2)" "unprognostic (1.11e-2)" "unprognostic (1.45e-1)" "unprognostic (4.56e-7)" "unprognostic (7.17e-2)" "unprognostic (1.71e-1)" "unprognostic (9.07e-3)" "unprognostic (6.29e-3)" "unprognostic (1.18e-1)" "unprognostic (1.01e-1)" "unprognostic (2.67e-4)" "unprognostic (3.70e-2)" "unprognostic (2.06e-2)" "unprognostic (7.15e-2)" "unprognostic (1.98e-1)" "unprognostic (1.38e-1)" "unprognostic (3.61e-2)" 0.3 0.6 2.2 0.2 2.4 0.0 0.1 0.7 2.8 0.1 0.8 0.6 0.1 0.0 0.0 0.0 0.0 0.2 0.0 1.5 3.9 0.0 0.0 0.1 0.0 4.4 6.8 0.0 0.0 0.0 1.3 0.0 10.9 0.0 0.2 0.7 0.1 0.1 0.0 0.1 0.3 0.1 2.9 0.0 0.1 1.2 2.7 0.0 0.3 0.0 0.0 0.0 0.0 2.1 0.1 0.0 0.5 0.0 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.6 0.0 4.3 0.0 0.0 0.1 0.4 31.7 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 3.7 0.0 5.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 2.4 0.7 2.8 1.5 3.9 4.4 6.8 10.9 2.9 2.7 2.1 0.0 0.0 0.0 66.6 0.0 0.0 0.0 0.0 0.0 1.9 0.2 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 42.1 0.5 0.1 0.2 0.0 0.0 12.5 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 3.4 0.0 274.2 0.0 0.0 0.0 0.0 41.2 0.0 0.5 0.0 7.5 0.0 0.6 0.0 433.8 21.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.1 0.1 0.8 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 ALKBH8 "MGC10235, TRM9, TRMT9A" ENSG00000137760 "AlkB homolog 8, tRNA methyltransferase" Q96BT7 11 107502727-107565742 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Methyltransferase, Multifunctional enzyme, RNA-binding, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 25.2;Inhibitory neurons: 27.4;Oligodendrocyte precursor cells: 23.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038724, HPA038725, HPA061514" Approved Supported "Nucleoplasm,Nuclear bodies" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 16: Immune cells - Immune response" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nuclear bodies" Nucleoplasm "HPA038724: AB_2676176, HPA038725: AB_10674838, HPA061514: AB_2684547" "unprognostic (2.66e-2)" "unprognostic (3.82e-1)" "unprognostic (8.19e-2)" "unprognostic (3.76e-1)" "unprognostic (4.04e-2)" "unprognostic (2.97e-1)" "unprognostic (1.22e-2)" "unprognostic (1.95e-1)" "unprognostic (4.45e-2)" "unprognostic (7.67e-2)" "unprognostic (1.89e-2)" "unprognostic (7.95e-2)" "unprognostic (2.81e-1)" "unprognostic (2.03e-1)" "unprognostic (2.04e-1)" "unprognostic (2.34e-3)" "unprognostic (1.01e-1)" 3.1 2.9 2.4 4.0 3.0 3.3 5.0 2.6 2.8 2.9 1.7 3.0 3.2 3.8 3.2 3.1 2.9 2.8 3.8 2.4 2.6 3.9 4.5 3.6 6.0 2.2 2.6 4.4 2.3 4.1 1.7 3.3 2.5 3.5 3.6 3.3 2.9 3.3 5.1 4.6 2.6 3.6 2.2 4.6 3.3 2.8 2.3 4.6 5.2 4.7 5.9 3.5 2.8 2.3 5.4 6.5 6.6 7.2 3.6 7.9 5.4 10.2 7.5 7.4 8.0 12.1 9.7 12.6 5.8 10.0 10.2 9.6 9.9 8.5 9.6 11.4 6.6 10.6 2.5 5.6 5.3 13.7 12.6 4.9 9.2 9.5 12.0 3.8 9.3 9.9 15.2 4.1 5.9 4.9 12.4 6.8 8.7 10.5 10.6 11.1 10.2 8.7 5.9 5.8 6.0 6.7 5.9 4.4 4.5 4.0 7.2 4.1 8.8 16.1 9.6 5.3 12.9 3.8 4.3 9.7 4.5 9.0 16.1 0.0 1.1 0.3 2.2 2.1 2.1 0.9 1.6 1.9 1.7 1.9 3.0 2.6 0.0 2.8 1.5 1.0 1.8 1.1 2.4 3.0 2.6 2.8 2.4 2.6 2.2 2.6 2.5 2.2 2.3 2.3 4.4 0.0 5.3 4.6 8.5 2.0 1.7 1.5 7.4 5.7 3.2 3.0 11.2 5.7 3.5 1.8 6.2 2.3 3.0 1.3 0.0 1.9 0.4 2.4 4.6 4.2 1.2 4.6 25.2 3.3 2.7 4.3 7.7 2.3 10.1 5.1 2.9 6.6 2.8 1.7 27.4 2.8 2.0 3.8 2.2 0.2 2.8 4.1 3.6 14.0 4.7 3.0 3.1 23.1 14.3 2.7 5.2 4.1 3.8 1.3 1.3 3.6 0.8 3.8 0.0 4.0 3.0 1.8 3.2 6.9 4.1 0.8 6.6 5.2 3.5 0.6 ALPK1 "FLJ22670, KIAA1527, Lak" ENSG00000073331 "Alpha kinase 1" Q96QP1 4 112285509-112442621 "Enzymes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins" "Immunity, Innate immunity" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Microglial cells: 73.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in many" "neutrophil: 18.7" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in some" "Low region specificity" "Detected in many" "HPA027435, HPA027443" Approved Approved Centrosome NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Centrosome "HPA027435: AB_10599614, HPA027443: AB_10599421" "unprognostic (6.24e-2)" "unprognostic (1.92e-1)" "unprognostic (9.30e-2)" "unprognostic (1.69e-2)" "unprognostic (7.40e-2)" "unprognostic (5.45e-2)" "unprognostic (2.55e-2)" "unprognostic (7.47e-2)" "unprognostic (2.34e-1)" "unprognostic (1.38e-1)" "unprognostic (7.14e-2)" "unprognostic (2.78e-1)" "prognostic unfavorable (5.82e-7)" "unprognostic (1.60e-1)" "unprognostic (4.17e-2)" "unprognostic (2.81e-1)" "prognostic favorable (1.17e-4)" 4.8 5.3 1.7 4.4 2.0 10.7 5.1 1.9 2.7 5.4 3.2 4.3 2.4 3.7 3.7 4.4 5.3 4.2 3.1 4.5 1.6 7.2 4.5 5.1 5.4 1.4 1.1 5.4 3.5 4.2 2.5 3.6 1.8 4.9 4.2 2.1 5.4 3.1 1.8 6.9 5.0 4.2 0.5 8.7 4.0 2.1 1.8 5.2 4.2 2.3 6.1 6.0 4.4 2.5 1.6 5.0 1.5 0.3 6.4 10.1 2.1 1.7 3.6 2.6 3.3 0.5 7.8 5.3 3.3 3.3 5.2 1.0 1.7 3.2 3.7 6.7 1.9 3.6 2.0 0.4 10.1 2.2 2.0 12.8 8.3 3.7 7.8 5.7 0.9 2.7 0.9 9.1 5.0 3.1 1.3 2.0 0.3 3.7 1.2 0.6 1.1 1.6 3.9 1.8 0.5 0.8 1.7 6.4 2.8 0.2 2.9 4.1 1.8 2.3 2.0 3.8 1.3 2.2 0.7 4.5 5.8 5.3 2.1 1.6 3.7 1.7 0.2 4.7 0.6 0.9 0.6 0.1 3.7 0.9 0.8 0.6 18.7 0.4 2.2 0.5 0.0 1.4 1.7 2.0 1.9 2.7 4.5 1.6 1.4 1.1 1.8 0.5 1.8 2.5 10.8 12.8 26.8 11.4 7.3 2.9 10.9 11.5 12.5 0.5 8.7 10.7 4.0 4.3 15.5 5.5 0.0 4.9 2.9 10.0 0.0 8.0 11.1 12.0 13.7 8.2 1.2 5.0 5.9 6.7 3.0 9.6 16.3 10.9 6.3 10.9 7.1 7.4 10.1 0.0 1.2 8.6 8.2 13.5 4.6 2.6 3.7 18.7 7.2 73.1 16.1 10.7 1.0 0.5 0.7 7.1 9.0 7.5 2.4 8.8 8.0 5.3 25.7 0.2 6.6 8.4 10.8 0.9 0.7 10.3 4.5 7.3 4.0 7.0 6.4 12.4 ALPK2 HAK ENSG00000198796 "Alpha kinase 2" Q86TB3 18 58481247-58629091 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "heart muscle: 41.9;skeletal muscle: 38.3;tongue: 33.2" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 120.4;Cone photoreceptor cells: 47.9;Early spermatids: 15.9;Late spermatids: 24.3;monocytes: 18.1" "Cancer enriched" "Detected in some" 6 "renal cancer: 7.3" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ: 51.2;BJ hTERT+: 31.0;fHDF/TERT166: 46.6;U-138 MG: 25.3" "Not detected" "Not detected" "Not detected" "Not detected" "HPA027377, HPA027976, HPA028084, HPA029801" Uncertain Approved Cytosol NA NA "Cluster 38: Heart - Muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 54: Cardiomyocytes - Muscle contraction" Cytosol "HPA027377: AB_10600635, HPA027976: AB_10611246, HPA028084: AB_10601996, HPA029801: AB_10602006" "unprognostic (7.35e-2)" "unprognostic (4.91e-2)" "unprognostic (1.64e-1)" "unprognostic (4.60e-3)" "unprognostic (2.64e-1)" "unprognostic (8.27e-2)" "unprognostic (1.22e-1)" "unprognostic (1.41e-1)" "unprognostic (3.44e-1)" "unprognostic (1.06e-1)" "unprognostic (5.13e-2)" "unprognostic (1.33e-2)" "prognostic unfavorable (8.20e-5)" "unprognostic (5.27e-3)" "unprognostic (2.50e-1)" "unprognostic (4.73e-2)" "unprognostic (3.20e-2)" 0.8 0.0 0.0 2.1 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.2 0.0 0.1 0.8 0.3 0.0 0.9 41.9 0.4 0.0 9.2 4.5 0.1 5.7 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.3 0.2 2.1 0.3 0.0 38.3 0.5 1.0 0.1 0.0 0.5 1.7 1.1 0.0 3.5 0.0 33.2 4.4 1.5 0.0 0.0 0.0 13.7 0.9 0.0 0.4 3.4 0.3 51.2 31.0 21.2 18.1 3.4 0.0 0.0 5.2 46.6 2.9 0.0 0.0 0.0 21.5 11.5 0.0 0.0 4.4 1.8 2.7 0.0 0.0 3.0 0.0 6.4 0.2 0.7 0.0 0.0 0.0 0.4 13.8 0.0 0.0 0.0 0.3 0.0 0.0 0.0 11.1 0.0 0.3 0.0 0.0 0.0 0.4 0.0 0.0 8.3 0.0 0.0 0.0 25.3 11.2 3.5 8.7 20.9 19.2 0.0 5.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.7 0.1 0.0 0.0 0.0 0.2 0.1 4.8 120.4 0.0 0.0 0.0 47.9 0.0 0.1 0.0 1.9 1.5 15.9 0.0 2.3 0.9 0.0 0.0 1.0 0.7 0.0 8.9 0.0 0.1 0.0 4.0 0.4 3.0 0.7 1.7 0.7 0.0 0.0 0.3 3.0 24.3 0.3 2.4 0.0 0.0 18.1 2.6 0.0 0.0 0.8 0.2 2.3 0.0 0.6 0.0 0.3 13.6 0.0 0.9 0.0 3.8 1.7 1.1 0.1 0.0 0.9 0.1 0.3 0.0 0.0 0.0 ALPK3 "KIAA1330, MAK, Midori" ENSG00000136383 "Alpha kinase 3" Q96L96 15 84817356-84873479 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Cardiomyopathy, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "heart muscle: 62.7;skeletal muscle: 195.8;tongue: 59.1" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 64.1;Exocrine glandular cells: 20.5;Skeletal myocytes: 51.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 14.3;HDLM-2: 10.7;HUVEC TERT2: 15.5;LHCN-M2: 21.2;NTERA-2: 12.9;RH-30: 37.7;THP-1: 9.6" "Not detected" "Not detected" "Low region specificity" "Detected in some" HPA026558 Uncertain Approved Nucleoplasm NA NA "Cluster 13: Striated muscle - Muscle contraction" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 37: Myocytes - Muscle contraction" Nucleoplasm "HPA026558: AB_1844774" "unprognostic (2.69e-2)" "unprognostic (1.42e-1)" "unprognostic (2.71e-2)" "unprognostic (4.61e-2)" "unprognostic (2.08e-1)" "unprognostic (6.53e-2)" "unprognostic (1.44e-3)" "unprognostic (1.42e-1)" "unprognostic (1.68e-2)" "unprognostic (1.82e-1)" "unprognostic (1.74e-3)" "unprognostic (1.23e-1)" "prognostic favorable (3.95e-7)" "unprognostic (1.76e-2)" "unprognostic (1.77e-1)" "unprognostic (2.96e-2)" "unprognostic (4.87e-2)" 12.5 9.6 1.2 0.9 1.6 0.1 4.4 1.0 2.2 2.2 9.3 7.5 0.6 1.5 5.4 3.0 1.7 1.8 62.7 1.3 3.8 13.5 5.9 5.5 0.6 2.2 3.4 0.8 7.7 11.2 26.1 2.5 4.5 2.4 0.8 2.5 2.6 1.3 195.8 1.0 2.1 3.1 1.6 0.5 5.2 0.9 3.9 0.6 3.6 59.1 0.4 3.6 1.4 1.1 1.8 0.1 0.1 0.2 0.3 0.1 14.3 0.0 0.0 0.0 0.1 0.1 6.3 0.0 0.4 0.0 0.1 1.1 0.0 0.0 0.1 10.7 1.7 1.8 0.3 0.0 0.2 0.0 0.1 1.3 0.2 0.0 0.0 0.1 15.5 0.1 0.0 0.1 21.2 0.9 0.0 0.2 12.9 0.3 0.1 0.0 37.7 0.2 0.0 4.0 0.0 0.2 0.0 2.0 0.1 1.9 0.1 9.6 0.3 0.1 0.0 0.0 0.0 0.3 0.9 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 1.6 1.0 2.2 1.3 3.8 2.2 3.4 4.5 1.6 3.9 1.1 3.3 6.4 2.7 2.6 0.2 0.9 0.1 0.6 1.2 4.1 1.3 0.8 64.1 17.2 2.4 9.2 16.7 0.3 0.2 0.5 0.0 2.9 0.3 11.5 1.0 8.7 9.1 0.0 3.0 20.5 0.7 3.8 0.5 8.9 1.3 8.7 1.8 1.7 10.2 0.0 3.4 0.3 0.0 0.3 12.0 0.0 0.0 5.2 3.6 9.4 4.7 1.0 1.0 0.5 0.3 10.4 1.2 0.0 1.5 0.7 0.1 2.2 4.2 3.4 0.0 51.9 8.4 0.5 3.2 0.2 0.1 0.7 0.5 0.2 0.3 1.6 AMFR "gp78, RNF45" ENSG00000159461 "Autocrine motility factor receptor" Q9UKV5 16 56361452-56425545 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway, Wnt signaling pathway" "Receptor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 154.5;Hepatocytes: 166.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB026381, HPA029018, HPA077835" Approved Supported "Endoplasmic reticulum,Golgi apparatus" NA NA "Cluster 42: Non-specific - Transcription" "Cluster 54: Non-specific - Microtubule organization" "Cluster 6: T47d - Mammary gland" "Cluster 2: Hepatocytes - Metabolism" "Endoplasmic reticulum, Golgi apparatus" "CAB026381: , HPA029018: AB_2672869, HPA077835: AB_2686856" "unprognostic (1.72e-2)" "unprognostic (1.62e-1)" "unprognostic (1.62e-2)" "unprognostic (2.43e-2)" "unprognostic (3.60e-3)" "unprognostic (6.06e-2)" "unprognostic (1.04e-1)" "unprognostic (1.26e-3)" "unprognostic (1.28e-1)" "unprognostic (1.43e-1)" "unprognostic (2.97e-1)" "unprognostic (4.16e-2)" "unprognostic (5.52e-3)" "unprognostic (1.45e-1)" "unprognostic (1.68e-1)" "unprognostic (1.91e-1)" "unprognostic (2.28e-1)" 29.6 53.1 49.7 22.8 58.0 36.9 27.5 56.6 48.0 34.4 78.5 29.1 47.5 33.6 51.5 44.2 31.7 29.2 32.1 50.2 56.7 64.8 75.4 27.1 40.2 62.1 58.4 40.1 29.2 70.6 24.2 41.0 62.6 28.0 25.0 57.6 25.6 37.4 159.4 24.9 36.0 33.9 65.3 26.9 24.6 83.7 57.2 20.6 33.8 56.5 43.5 25.8 29.4 75.7 55.5 75.2 32.4 59.2 98.2 54.7 28.4 56.8 71.2 77.0 60.1 66.4 49.4 142.0 65.3 79.1 45.2 50.3 49.9 45.1 72.9 31.7 51.2 40.9 29.2 73.4 85.7 33.2 45.6 64.1 64.3 61.7 73.1 53.6 45.6 41.0 45.7 18.8 56.9 33.7 50.7 35.8 15.3 28.2 51.1 57.0 64.8 53.6 47.9 57.0 32.2 24.6 135.6 47.3 45.5 30.3 142.3 35.0 59.4 72.3 39.4 36.9 39.7 40.7 38.5 75.8 52.7 23.4 33.7 37.1 10.0 14.4 7.9 12.5 11.2 21.7 9.9 8.3 9.9 17.9 10.1 10.9 12.5 14.2 17.9 13.2 11.4 5.5 49.7 58.0 56.6 48.0 50.2 56.7 62.1 58.4 62.6 65.3 57.2 75.7 25.7 9.6 9.0 23.8 34.0 25.7 18.1 11.0 10.8 17.7 58.9 23.0 19.9 28.6 11.7 99.3 39.6 27.5 17.4 53.6 25.4 20.8 154.5 16.4 26.4 23.5 24.7 29.0 20.5 43.0 6.8 31.9 8.6 32.4 8.8 31.8 38.9 166.4 17.0 32.0 23.7 23.6 12.2 69.1 33.2 118.7 41.0 25.5 30.2 23.4 25.5 50.1 10.3 27.6 31.5 35.6 25.3 34.3 12.0 36.0 53.4 54.3 9.2 43.3 13.1 29.4 24.1 30.5 11.7 12.0 20.9 24.4 17.1 34.1 22.9 29.7 AMHR2 "MISR2, MISRII" ENSG00000135409 "Anti-Mullerian hormone receptor type 2" Q16671 12 53423855-53431672 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Disease variant, Pseudohermaphroditism" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "adrenal gland: 41.5;ovary: 33.1" "Group enriched" "Detected in some" 4 "granulocytes: 26.0;Granulosa cells: 36.1;Theca cells: 94.9" "Cancer enhanced" "Detected in single" "testis cancer: 0.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 19 "HEL: 40.1;K-562: 22.2" "Low region specificity" "Detected in many" "Region enriched" "Detected in single" 11 "hippocampal formation: 9.4" "HPA060228, HPA069636" Approved Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 51: Non-specific - Unknown function" "Cluster 36: HEL - Hemostasis" "Cluster 52: Non-specific - Transcription" Vesicles "Nucleoplasm, Cytosol" "HPA060228: AB_2684227, HPA069636: AB_2686163" "unprognostic (5.79e-2)" "unprognostic (3.65e-1)" "unprognostic (3.98e-1)" "unprognostic (1.71e-1)" "unprognostic (1.14e-1)" "unprognostic (4.61e-3)" "unprognostic (2.33e-1)" "unprognostic (1.44e-2)" "unprognostic (2.91e-1)" "unprognostic (4.98e-2)" "unprognostic (1.35e-1)" "unprognostic (2.32e-1)" "unprognostic (2.15e-2)" "unprognostic (3.34e-2)" "unprognostic (1.42e-1)" "unprognostic (2.04e-1)" "unprognostic (1.97e-1)" 0.6 41.5 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.2 0.0 0.1 0.1 0.1 0.0 0.3 0.4 0.1 0.5 0.0 0.3 0.0 0.9 0.4 0.0 0.0 0.2 33.1 12.5 0.4 0.1 0.0 0.0 0.1 0.1 0.0 0.1 0.0 4.2 0.1 0.1 0.0 0.0 5.7 0.7 9.1 0.5 0.0 0.0 1.8 0.0 0.2 0.1 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 1.6 40.1 0.0 0.8 0.0 0.0 1.3 0.1 0.0 0.0 0.0 0.1 0.0 0.0 22.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.9 3.5 2.6 0.0 0.1 1.5 0.0 4.2 0.1 2.1 0.1 2.7 0.0 0.1 26.0 36.1 11.4 0.3 0.1 0.0 0.0 0.0 0.0 1.2 0.0 2.5 5.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 0.0 4.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.3 1.1 0.3 0.0 0.0 0.3 0.8 94.9 0.1 0.0 AMT "GCST, NKH" ENSG00000145020 Aminomethyltransferase P48728 3 49416778-49422685 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Aminotransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 49.1" "Cell type enhanced" "Detected in many" "Hepatocytes: 42.4;Proximal enterocytes: 33.3;Undifferentiated cells: 31.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "NK-cell: 7.9" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in some" "BEWO: 17.1;Hep G2: 47.5;NTERA-2: 8.0;SH-SY5Y: 14.9;SuSa: 9.0" HPA005566 Supported Supported Nucleoplasm,Mitochondria NA NA "Cluster 40: NK-cells - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 53: Intestinal epithelial cells - Unknown function" Mitochondria Nucleoplasm "HPA005566: AB_1844811" "unprognostic (2.10e-2)" "unprognostic (1.65e-2)" "unprognostic (1.82e-1)" "unprognostic (9.14e-3)" "unprognostic (4.04e-1)" "unprognostic (1.11e-2)" "unprognostic (2.81e-1)" "unprognostic (2.17e-3)" "unprognostic (1.94e-1)" "unprognostic (3.29e-1)" "unprognostic (7.17e-3)" "unprognostic (1.88e-1)" "prognostic favorable (3.90e-8)" "unprognostic (4.40e-1)" "unprognostic (1.91e-1)" "unprognostic (3.60e-1)" "unprognostic (1.98e-3)" 4.7 12.8 9.8 1.2 10.3 8.8 5.6 10.7 11.7 11.8 13.1 12.2 13.8 6.8 8.2 3.5 10.1 5.8 21.6 9.4 9.6 23.2 49.1 5.4 2.1 9.8 10.2 12.5 19.5 14.2 11.9 2.3 9.8 11.3 11.8 6.5 10.6 8.5 3.1 4.8 12.1 3.7 9.9 6.3 11.1 3.0 10.0 3.8 5.8 4.2 1.5 8.0 6.4 9.9 0.1 0.7 1.4 0.4 0.6 0.0 17.1 0.0 0.4 0.1 0.3 0.5 0.6 0.0 0.2 0.4 0.0 0.3 0.1 0.7 0.1 0.3 0.0 0.0 0.5 47.5 1.8 0.0 0.0 0.6 1.8 0.0 0.7 1.3 0.6 0.2 0.0 0.0 0.2 0.4 0.1 0.1 8.0 0.0 0.2 0.0 0.5 1.0 0.8 0.4 0.0 14.9 0.2 0.0 1.1 9.0 0.1 0.3 0.6 0.1 0.0 0.3 0.0 1.0 0.0 0.0 0.0 0.3 0.0 0.0 2.1 3.2 0.0 1.7 0.0 0.5 0.0 0.0 4.2 0.2 1.2 0.9 0.1 7.9 0.5 0.3 0.0 1.3 9.8 10.3 10.7 11.7 9.4 9.6 9.8 10.2 9.8 9.9 10.0 9.9 1.2 3.2 9.2 11.4 3.6 2.8 12.1 3.1 3.4 17.4 1.2 1.3 21.8 14.3 6.3 0.0 20.9 25.6 1.4 13.8 0.0 0.8 2.5 0.7 1.6 3.2 12.7 8.8 8.7 0.7 8.8 4.5 15.8 1.0 7.6 2.0 3.9 42.4 5.0 8.4 8.5 18.4 2.0 3.8 2.9 1.6 10.5 2.6 5.4 7.5 1.8 26.0 7.2 6.0 6.6 0.6 18.9 6.4 1.1 6.7 33.3 1.1 6.6 19.3 6.6 5.2 3.1 1.9 0.3 2.2 2.7 10.3 3.8 1.0 31.6 10.9 ANKIB1 "DKFZP434A0225, KIAA1386" ENSG00000001629 "Ankyrin repeat and IBR domain containing 1" Q9P2G1 7 92245974-92401383 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 85.5" "Cell type enhanced" "Detected in all" "Excitatory neurons: 182.5;Inhibitory neurons: 218.0;Oligodendrocyte precursor cells: 176.5;Oligodendrocytes: 590.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019358, HPA021780" Uncertain Supported "Plasma membrane,Cytosol" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 70: Brain - Nervous system development" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Plasma membrane, Cytosol" "HPA019358: AB_1844831, HPA021780: AB_2670819" "unprognostic (1.77e-1)" "unprognostic (5.96e-3)" "unprognostic (1.23e-1)" "unprognostic (4.97e-3)" "unprognostic (2.75e-1)" "unprognostic (7.67e-2)" "unprognostic (4.88e-3)" "unprognostic (2.14e-1)" "unprognostic (4.24e-2)" "unprognostic (1.87e-2)" "unprognostic (1.52e-3)" "unprognostic (1.48e-1)" "unprognostic (1.06e-3)" "unprognostic (4.05e-2)" "unprognostic (3.00e-1)" "unprognostic (3.00e-2)" "unprognostic (3.20e-1)" 12.6 10.6 28.4 10.0 56.8 6.9 12.3 21.2 42.0 12.6 0.0 12.9 11.1 12.0 15.9 11.8 9.8 14.9 10.2 19.0 54.6 25.6 10.6 11.0 13.2 32.9 32.4 12.6 12.2 23.9 7.5 12.7 34.5 10.0 12.8 9.9 13.9 11.2 7.7 14.4 12.0 13.6 14.0 12.4 11.7 20.8 36.3 14.5 17.2 9.9 11.7 13.2 9.0 85.5 35.7 20.9 18.7 27.3 32.0 34.9 19.2 27.1 30.0 25.4 34.0 15.8 52.0 20.0 23.4 39.7 66.8 16.5 16.5 28.1 38.0 35.1 14.0 13.1 23.7 12.1 22.0 18.8 26.5 23.1 22.8 31.0 38.2 34.6 28.7 17.4 16.9 41.8 30.0 27.5 39.6 17.0 19.6 23.9 23.7 14.6 22.8 21.9 26.6 30.7 25.5 29.4 39.2 41.8 22.4 34.8 17.5 10.2 26.2 48.5 40.2 55.3 27.8 26.7 52.3 25.4 27.7 21.9 56.2 1.4 0.4 1.2 0.9 0.7 0.7 1.7 0.9 1.3 0.4 2.0 0.7 1.0 0.2 1.2 0.6 1.6 1.9 0.4 28.4 56.8 21.2 42.0 19.0 54.6 32.9 32.4 34.5 14.0 36.3 85.5 24.1 25.6 30.4 97.6 21.8 18.6 17.5 16.4 13.1 20.8 25.6 20.2 33.4 24.3 22.3 27.6 18.8 13.4 27.8 20.7 1.9 21.5 52.8 21.5 37.2 22.4 41.9 8.8 182.5 19.2 25.2 25.9 14.3 27.0 26.6 47.4 27.8 15.1 13.5 30.3 218.0 24.8 10.2 22.2 16.1 61.1 33.2 20.4 17.8 87.1 20.6 27.3 34.0 176.5 590.8 33.5 11.8 40.6 23.4 26.5 20.8 37.3 18.8 16.2 19.7 34.8 26.1 70.9 50.4 20.3 22.7 14.0 22.7 31.2 21.7 21.9 ANKK1 X-kinase ENSG00000170209 "Ankyrin repeat and kinase domain containing 1" Q8NFD2 11 113387779-113400416 "Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "skin 1: 3.5" "Cell type enhanced" "Detected in some" "Basal respiratory cells: 7.2;Club cells: 2.4;Ionocytes: 6.1;Respiratory ciliated cells: 6.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "hTCEpi: 2.1;RT4: 1.0" "Not detected" "Not detected" HPA012813 Uncertain NA NA "Cluster 27: Brain & Skin - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "HPA012813: AB_1844832" "unprognostic (5.63e-3)" "unprognostic (6.67e-3)" "unprognostic (5.09e-3)" "unprognostic (6.27e-3)" "unprognostic (5.56e-4)" "unprognostic (7.02e-2)" "unprognostic (2.07e-1)" "unprognostic (1.75e-1)" "unprognostic (4.50e-1)" "unprognostic (3.15e-1)" "unprognostic (3.36e-2)" "unprognostic (2.18e-1)" "unprognostic (5.39e-6)" "unprognostic (3.17e-2)" "unprognostic (3.83e-2)" "unprognostic (2.79e-1)" "unprognostic (4.65e-2)" 0.2 0.5 0.6 0.2 2.7 0.1 0.7 0.5 1.0 1.1 2.0 0.3 0.1 0.4 0.3 0.5 2.0 0.0 0.1 0.4 0.7 0.4 0.3 0.6 0.4 1.0 3.1 0.7 0.3 0.1 3.0 0.0 0.7 1.5 0.0 0.6 1.3 0.3 0.3 3.5 0.6 0.0 0.7 0.8 0.2 1.0 1.1 0.1 0.7 0.0 0.2 0.4 1.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 2.7 0.5 1.0 0.4 0.7 1.0 3.1 0.7 0.7 1.1 0.7 0.2 0.0 0.5 1.6 0.2 0.6 0.8 7.2 0.0 1.2 0.3 1.1 0.4 0.0 2.4 0.0 0.0 0.2 0.2 0.1 0.0 0.0 0.2 1.9 0.1 0.2 0.0 0.0 0.7 0.0 0.0 0.3 0.0 0.1 0.0 0.1 0.0 0.0 0.0 1.7 0.2 0.2 6.1 0.0 0.3 0.1 0.0 0.1 0.0 0.0 0.0 0.6 0.0 0.5 1.1 0.0 1.1 0.0 0.0 0.5 0.0 0.0 6.0 0.9 0.0 1.3 0.4 0.1 0.1 0.0 0.6 0.0 0.5 0.2 0.0 0.5 AP000812.4 ENSG00000284922 "Leucine rich transmembrane and O-methyltransferase domain containing" Q8WZ04 11 72080331-72110782 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Catecholamine metabolism, Hearing, Neurotransmitter degradation" "Methyltransferase, Transferase" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 7 "fallopian tube: 14.1;testis: 9.5" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "fHDF/TERT166: 2.9;HBEC3-KT: 2.9;MCF7: 3.0" HPA039949 Approved Uncertain Microtubules NA NA "Cluster 40: Non-specific - Basic cellular processes" Microtubules "HPA039949: AB_10960708" 0.1 0.0 0.4 0.0 0.5 0.0 0.2 0.6 1.8 0.0 0.1 0.0 0.0 0.9 0.0 0.0 14.1 0.0 0.0 0.3 0.6 0.4 0.2 0.6 0.0 0.4 0.4 0.2 0.0 0.5 0.0 0.4 0.0 0.1 0.1 0.0 0.2 0.4 0.0 0.2 0.2 0.3 0.2 0.0 9.5 0.4 0.0 0.1 0.0 0.0 0.1 0.6 0.2 0.1 0.0 0.2 0.7 0.2 0.1 0.4 0.5 0.3 1.2 0.2 0.2 0.0 0.1 2.9 0.5 0.6 0.4 2.9 0.3 1.2 0.5 0.5 0.2 0.2 0.0 0.0 0.0 0.8 0.0 1.3 0.4 0.1 0.1 0.6 0.0 0.0 0.4 3.0 0.0 0.0 0.1 1.0 0.0 0.6 0.5 0.2 0.9 0.5 0.3 0.1 0.4 0.3 0.0 0.0 0.9 0.1 0.0 0.2 0.2 0.4 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.5 0.6 1.8 0.3 0.6 0.4 0.4 0.4 0.3 0.4 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 APRT ENSG00000198931 "Adenine phosphoribosyltransferase" P07741 16 88809339-88811937 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Purine salvage" "Glycosyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA026681 Approved Approved Nucleoplasm,Cytosol NA NA 1600000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 18: Non-specific - Mitochondria" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 32: Non-specific - Translation" "Nucleoplasm, Cytosol" "HPA026681: AB_1844964" "unprognostic (5.87e-2)" "unprognostic (5.10e-2)" "unprognostic (1.98e-1)" "unprognostic (3.67e-2)" "unprognostic (1.78e-1)" "unprognostic (2.50e-3)" "unprognostic (1.72e-3)" "unprognostic (6.90e-2)" "unprognostic (1.71e-1)" "unprognostic (1.82e-1)" "unprognostic (6.78e-2)" "unprognostic (8.74e-2)" "unprognostic (9.58e-3)" "unprognostic (1.14e-1)" "unprognostic (2.51e-1)" "unprognostic (4.75e-2)" "unprognostic (1.48e-2)" 118.5 161.2 30.1 73.6 30.1 103.1 112.3 32.0 39.5 109.6 39.3 121.0 72.2 81.2 25.5 231.1 87.6 31.4 70.2 29.9 32.0 128.7 190.4 85.8 83.8 32.9 31.3 73.3 169.4 66.1 64.9 37.0 32.1 113.6 40.2 5.1 119.8 44.6 62.7 240.1 106.8 29.8 33.7 128.6 131.8 35.2 35.1 77.2 96.9 23.8 64.5 95.7 153.7 35.7 157.9 228.3 44.9 200.4 54.2 106.0 232.2 117.1 105.0 136.0 52.6 237.6 189.0 145.5 221.9 68.4 65.0 165.3 74.8 195.4 27.5 102.9 417.7 124.3 106.5 253.0 168.1 87.4 97.7 113.1 207.6 109.0 139.4 63.7 172.6 244.6 266.6 107.9 71.4 586.0 242.1 254.7 169.4 169.5 288.8 259.2 69.2 351.5 156.3 107.0 218.2 132.4 223.5 130.7 131.2 41.9 427.9 171.1 111.4 122.5 104.9 99.5 118.0 205.9 186.5 408.8 179.9 228.4 110.5 77.7 544.5 202.8 474.5 473.5 631.7 501.1 612.0 510.3 562.4 517.3 557.8 475.3 31.8 501.8 322.1 731.6 551.8 998.0 30.1 30.1 32.0 39.5 29.9 32.0 32.9 31.3 32.1 33.7 35.1 35.7 146.5 115.4 147.4 5.9 247.0 319.0 320.0 375.7 207.7 19.9 346.2 479.7 46.9 230.2 206.8 92.0 6.2 265.0 262.3 273.1 406.9 404.3 11.8 124.6 180.3 163.1 210.8 150.6 5.1 442.6 401.5 170.3 192.7 148.4 131.9 154.9 147.8 309.6 348.0 15.2 4.4 386.4 160.7 253.9 336.1 35.4 239.9 214.6 297.1 3.7 449.4 78.7 355.3 2.5 7.2 392.3 228.3 135.4 171.6 404.3 349.2 647.9 125.5 20.4 39.5 135.6 186.5 18.4 126.9 358.8 494.7 172.7 285.7 339.5 426.7 385.2 ARAF ARAF1 ENSG00000078061 "A-Raf proto-oncogene, serine/threonine kinase" P10398 X 47561205-47571908 "Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA066326 Approved NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 27: Mucus-secreting cells - Mucin production" "HPA066326: AB_2685659" "unprognostic (1.21e-1)" "unprognostic (5.69e-3)" "unprognostic (2.47e-2)" "unprognostic (2.10e-2)" "unprognostic (7.63e-2)" "unprognostic (9.35e-2)" "unprognostic (1.79e-2)" "unprognostic (1.07e-1)" "unprognostic (3.76e-2)" "unprognostic (1.61e-1)" "unprognostic (6.75e-2)" "unprognostic (8.65e-2)" "prognostic favorable (1.45e-6)" "unprognostic (1.97e-1)" "unprognostic (2.01e-1)" "unprognostic (6.37e-2)" "unprognostic (4.71e-2)" 37.7 41.7 17.8 36.9 20.8 102.3 36.2 19.2 21.1 34.8 22.6 40.9 37.8 36.6 21.2 32.2 35.0 32.5 50.8 17.1 18.0 44.6 55.7 39.4 40.4 22.8 20.5 39.5 59.1 51.8 27.7 31.3 20.1 40.9 33.3 15.4 45.1 34.6 136.3 36.0 39.7 31.3 18.8 46.1 46.7 12.0 21.0 38.0 39.4 85.6 31.5 36.1 30.8 20.4 49.1 69.5 29.2 46.9 43.5 34.2 39.0 40.3 42.3 58.6 54.1 57.2 58.6 29.0 32.4 54.6 49.2 67.3 51.8 56.3 34.3 53.5 61.9 29.4 74.4 30.6 61.4 58.3 85.1 45.0 56.0 56.2 49.6 39.2 45.9 36.0 55.2 55.7 40.5 83.3 42.6 64.0 41.8 41.2 77.8 39.2 38.0 65.5 34.4 46.7 32.8 25.0 43.7 39.7 24.5 47.0 74.9 43.3 44.2 38.0 42.5 76.2 41.4 71.1 49.2 22.5 50.8 65.3 31.1 48.3 47.8 61.3 44.1 57.8 40.3 32.6 38.4 40.9 55.2 37.3 33.5 40.5 37.8 38.7 67.9 40.4 41.6 50.8 17.8 20.8 19.2 21.1 17.1 18.0 22.8 20.5 20.1 18.8 21.0 20.4 13.3 16.0 29.2 7.5 25.8 15.7 25.0 29.0 18.2 5.3 15.0 9.8 25.1 34.3 22.0 18.4 10.4 33.0 26.3 43.8 23.5 29.3 1.3 11.4 10.8 17.5 31.8 22.3 5.0 34.3 30.4 16.9 39.3 15.6 16.5 13.6 24.3 42.6 28.0 13.5 5.5 35.9 40.7 26.4 21.6 4.3 17.4 25.8 33.8 4.7 43.7 18.4 32.0 8.5 8.9 26.2 41.5 17.7 27.9 20.3 44.6 27.1 11.5 9.0 19.7 15.9 18.0 8.2 10.5 17.7 16.2 44.6 26.5 12.5 32.3 24.6 AREL1 "FIEL1, KIAA0317" ENSG00000119682 "Apoptosis resistant E3 ubiquitin protein ligase 1" O15033 14 74653437-74713117 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA051306 Uncertain NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 52: Non-specific - Transcription" "HPA051306: AB_2681433" "unprognostic (1.92e-1)" "unprognostic (1.34e-1)" "unprognostic (1.76e-1)" "unprognostic (1.92e-3)" "unprognostic (1.29e-1)" "unprognostic (2.49e-2)" "unprognostic (1.58e-3)" "unprognostic (9.32e-2)" "unprognostic (1.09e-1)" "unprognostic (1.32e-1)" "unprognostic (2.24e-1)" "unprognostic (2.12e-1)" "prognostic favorable (4.67e-6)" "unprognostic (6.73e-2)" "unprognostic (3.14e-1)" "unprognostic (1.52e-1)" "unprognostic (7.18e-2)" 6.2 6.9 4.3 10.4 4.7 16.9 6.7 3.1 4.8 7.8 3.3 10.4 11.8 6.5 7.1 10.0 10.4 6.7 10.6 6.7 5.0 14.6 5.3 9.0 10.0 3.1 4.1 6.8 9.5 15.4 4.5 8.3 2.6 8.4 12.3 13.3 9.7 7.7 9.9 7.8 12.7 8.4 3.7 8.5 9.8 17.1 5.6 13.1 15.5 13.1 13.3 10.0 5.6 3.5 19.2 24.6 25.1 23.6 21.3 14.1 19.3 20.7 23.5 25.2 25.1 19.2 22.2 16.4 10.8 26.6 22.9 25.3 26.9 23.2 32.4 30.4 12.7 25.5 14.5 13.7 14.2 18.5 23.9 18.4 15.8 18.6 20.0 31.6 25.0 23.5 20.3 17.1 32.9 25.8 19.2 7.8 15.4 26.0 24.2 19.5 28.4 10.2 20.5 42.6 24.6 33.0 18.1 23.9 13.4 16.6 21.0 18.5 34.6 23.8 28.5 14.3 24.3 22.6 32.8 32.2 28.8 14.0 18.8 2.2 3.5 7.1 4.6 5.1 3.3 2.1 2.8 4.2 4.5 1.4 2.9 2.6 6.8 3.4 2.7 2.1 2.6 3.4 4.3 4.7 3.1 4.8 6.7 5.0 3.1 4.1 2.6 3.7 5.6 3.5 3.7 12.8 4.6 23.2 6.5 3.6 3.4 6.0 7.4 12.3 7.0 3.7 11.1 5.7 7.5 11.0 27.1 4.2 11.2 18.3 1.9 6.6 3.1 7.2 7.1 5.0 14.9 21.0 24.8 9.2 3.3 4.6 12.8 10.5 1.3 10.3 6.4 12.9 8.0 16.8 24.1 11.6 8.2 15.0 5.3 4.6 8.7 9.6 5.4 23.4 13.9 5.2 11.3 22.6 32.5 11.2 6.5 6.8 9.1 6.8 11.8 5.1 7.3 11.7 0.0 4.4 4.9 6.7 11.1 10.5 3.3 5.9 8.4 6.4 11.5 6.3 ARIH1 "ARI, HARI, HHARI, UBCH7BP" ENSG00000166233 "Ariadne RBR E3 ubiquitin protein ligase 1" Q9Y4X5 15 72474330-72602987 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 47.8;testis: 42.5" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003295 Approved Supported Nucleoplasm NA NA "Cluster 46: Basophils - DNA binding" "Cluster 23: Testis - Cell cycle regulation" "Cluster 18: U-2197 - ECM organization" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "HPA003295: AB_1845017" "unprognostic (3.31e-2)" "unprognostic (1.92e-1)" "unprognostic (2.25e-1)" "unprognostic (3.18e-2)" "unprognostic (8.21e-2)" "unprognostic (5.45e-2)" "unprognostic (1.73e-1)" "unprognostic (9.43e-2)" "unprognostic (7.92e-2)" "unprognostic (1.37e-1)" "unprognostic (4.96e-2)" "unprognostic (9.19e-2)" "unprognostic (1.78e-1)" "unprognostic (2.93e-1)" "unprognostic (3.19e-1)" "unprognostic (1.04e-1)" "unprognostic (5.70e-2)" 8.5 7.9 2.5 10.1 3.9 16.5 6.0 7.0 5.8 6.4 7.1 8.2 9.5 7.5 3.2 6.8 5.4 4.4 11.4 4.4 4.0 5.2 6.2 7.3 4.9 3.4 2.7 9.0 6.6 3.9 5.9 6.5 3.6 5.8 3.3 10.4 4.3 4.8 47.8 7.6 7.4 6.3 3.0 6.0 6.3 42.5 3.8 3.9 5.0 8.5 4.1 7.6 6.5 4.3 17.6 18.0 17.5 10.2 8.9 6.2 20.6 19.3 7.0 8.6 5.9 18.3 14.6 17.2 28.4 8.3 30.3 24.8 18.1 10.1 4.8 30.6 12.4 13.0 22.5 12.4 6.3 19.6 14.4 7.4 3.4 9.5 12.2 8.2 6.4 12.4 13.8 19.7 8.5 11.5 18.9 7.5 18.9 6.3 6.5 21.4 21.3 9.8 4.8 29.0 16.3 18.4 25.1 11.2 31.4 23.0 9.0 22.0 16.7 14.1 19.6 54.8 27.4 20.7 45.2 20.6 9.2 17.5 15.2 1.6 0.2 0.7 0.5 0.4 0.4 0.2 0.3 0.3 0.2 0.6 0.4 0.4 1.0 0.6 0.2 0.3 0.8 0.1 2.5 3.9 7.0 5.8 4.4 4.0 3.4 2.7 3.6 3.0 3.8 4.3 79.5 19.2 37.7 88.5 64.0 66.3 52.7 13.3 76.2 63.3 74.9 53.3 46.9 30.0 25.7 18.4 91.8 18.4 83.3 32.9 3.9 18.4 110.3 108.7 84.8 50.7 46.5 24.8 141.6 18.9 21.8 43.3 63.7 148.4 43.2 43.7 40.0 28.5 19.0 62.2 152.0 31.2 8.2 30.5 42.1 55.4 28.6 67.5 16.0 104.0 24.2 25.7 27.8 129.7 135.1 24.7 19.1 27.4 60.9 55.8 20.8 13.9 33.0 58.8 19.7 96.8 59.9 45.3 32.1 68.8 59.8 40.8 68.3 36.8 27.0 63.7 ARIH2 TRIAD1 ENSG00000177479 "Ariadne RBR E3 ubiquitin protein ligase 2" O95376 3 48918821-48986382 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA067381, HPA069715, HPA070963" Enhanced Nucleoplasm NA NA "Cluster 44: Non-specific - Transcription" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" Nucleoplasm "HPA067381: AB_2685827, HPA069715: AB_2686182, HPA070963: AB_2686329" "unprognostic (7.24e-2)" "unprognostic (1.08e-1)" "unprognostic (1.26e-1)" "unprognostic (2.74e-1)" "unprognostic (2.55e-1)" "unprognostic (4.79e-3)" "prognostic unfavorable (1.70e-4)" "unprognostic (1.90e-2)" "unprognostic (4.01e-2)" "unprognostic (5.01e-2)" "prognostic favorable (7.31e-4)" "unprognostic (5.01e-3)" "prognostic favorable (6.60e-4)" "unprognostic (1.15e-1)" "unprognostic (7.04e-2)" "unprognostic (1.27e-2)" "unprognostic (1.39e-2)" 20.6 22.9 21.4 16.0 24.5 23.0 19.8 24.2 23.7 21.4 24.7 29.4 11.7 24.5 33.8 19.5 21.3 15.0 53.9 21.3 23.4 22.7 21.3 19.7 20.7 22.9 22.9 20.7 24.1 24.4 26.0 18.4 23.8 23.1 17.7 32.4 18.6 21.9 100.4 16.5 21.2 24.4 22.0 24.3 22.5 27.0 22.8 26.1 22.0 79.6 21.4 23.6 17.4 27.7 40.4 39.6 37.6 53.2 54.3 29.7 52.4 46.3 53.5 56.5 62.1 42.0 35.0 84.1 21.4 49.8 82.0 23.5 77.9 47.2 68.7 57.0 48.1 85.3 51.7 34.5 48.9 63.4 39.5 31.9 70.2 70.9 94.9 32.2 43.1 38.3 68.4 54.6 50.7 27.8 65.4 25.8 64.3 43.3 59.5 23.5 42.8 70.2 32.9 54.1 16.4 44.8 47.7 56.1 45.0 44.1 28.6 43.8 41.4 34.1 49.4 52.5 74.0 72.8 148.1 103.3 37.3 51.9 43.7 53.1 34.6 39.9 44.2 32.2 30.5 28.8 28.2 37.1 32.3 34.2 29.2 37.3 25.6 25.8 20.9 29.9 35.5 39.3 21.4 24.5 24.2 23.7 21.3 23.4 22.9 22.9 23.8 22.0 22.8 27.7 37.0 35.3 31.4 54.9 50.2 50.9 51.5 27.3 68.3 57.0 35.5 35.3 74.6 32.9 44.0 29.5 87.6 36.4 76.0 31.3 29.4 33.8 15.3 33.5 48.3 38.4 16.7 76.2 50.0 43.2 36.2 40.1 42.3 38.1 45.5 42.3 28.5 44.6 26.6 57.2 59.1 26.2 14.2 32.8 35.7 11.3 41.7 44.6 30.2 38.4 45.2 42.2 95.8 42.3 128.6 42.1 23.0 43.2 85.0 78.9 20.8 34.3 30.6 82.5 26.3 51.5 48.6 165.7 89.7 59.4 54.0 53.4 66.8 37.7 31.6 67.0 ART1 "ART2, ARTC1, CD296" ENSG00000129744 "ADP-ribosyltransferase 1" P52961 11 3645128-3664416 "CD markers, Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Group enriched" "Detected in some" 57 "skeletal muscle: 47.4;tongue: 36.8" "Cell type enhanced" "Detected in single" "Microglial cells: 1.9" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA051148 Uncertain NA NA "Cluster 13: Striated muscle - Muscle contraction" "Cluster 64: Astrocytes - Nervous system maintenance" "HPA051148: AB_2681363" "unprognostic (3.73e-1)" "unprognostic (4.58e-2)" "unprognostic (3.12e-2)" "unprognostic (1.35e-1)" "unprognostic (3.01e-1)" "unprognostic (1.19e-1)" "unprognostic (1.06e-1)" "unprognostic (1.73e-1)" 0.0 0.0 0.4 0.0 0.2 0.0 0.0 0.4 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.1 0.3 0.2 0.1 0.0 0.4 0.0 0.3 0.3 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.0 0.1 0.1 47.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.1 36.8 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.2 0.4 0.5 0.3 0.2 0.3 0.3 0.3 0.1 0.2 0.1 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ART3 ARTC3 ENSG00000156219 "ADP-ribosyltransferase 3 (inactive)" Q13508 4 76011184-76112802 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 12 "heart muscle: 67.3;skeletal muscle: 220.2;testis: 96.4;tongue: 101.6" "Group enriched" "Detected in some" 4 "Cardiomyocytes: 76.2;Spermatocytes: 262.8" "Cancer enhanced" "Detected in some" "breast cancer: 2.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 8 "NB-4: 5.5;NTERA-2: 14.1;SK-MEL-30: 6.7" "Low region specificity" "Detected in all" "Not detected" "Not detected" HPA011268 Enhanced "Intracellular and membrane" NA NA 48000000 "Cluster 80: Striated muscle - Unknown function" "Cluster 5: NTERA-2 - Transcription" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA011268: AB_1845059" "unprognostic (2.45e-1)" "unprognostic (2.84e-2)" "unprognostic (3.12e-2)" "unprognostic (2.77e-3)" "unprognostic (4.53e-2)" "unprognostic (1.34e-1)" "unprognostic (3.34e-1)" "unprognostic (9.85e-4)" "unprognostic (2.35e-1)" "unprognostic (5.10e-2)" "unprognostic (1.64e-2)" "unprognostic (2.95e-1)" "unprognostic (1.73e-2)" "unprognostic (2.53e-1)" "unprognostic (1.48e-1)" "unprognostic (2.58e-2)" "unprognostic (6.61e-3)" 1.0 0.4 3.4 1.1 4.2 0.0 0.9 6.9 9.4 2.2 4.0 3.7 0.3 0.3 0.5 4.7 0.9 0.2 67.3 4.7 4.6 0.2 0.2 0.4 0.3 3.3 3.3 0.4 7.9 0.1 2.5 0.1 2.8 2.0 2.2 0.2 3.1 1.3 220.2 0.9 2.3 0.4 3.5 2.7 1.9 96.4 2.7 0.6 0.3 101.6 0.1 0.7 1.7 9.9 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.4 0.0 1.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 5.5 14.1 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.7 0.6 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 1.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.4 4.2 6.9 9.4 4.7 4.6 3.3 3.3 2.8 3.5 2.7 9.9 0.4 0.0 0.0 0.7 0.1 0.5 0.5 1.1 0.0 0.5 0.2 0.3 76.2 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 23.3 2.1 0.4 0.8 0.0 0.0 37.9 0.0 0.1 2.6 0.0 5.9 0.0 0.0 0.0 0.0 0.1 0.0 1.7 0.0 0.0 0.0 0.4 13.5 1.8 0.2 1.8 0.0 0.0 0.3 0.0 5.0 7.3 0.0 0.0 1.2 0.0 1.0 0.0 0.0 0.1 0.3 0.0 21.7 2.7 262.8 24.2 0.0 0.3 0.0 0.2 0.1 0.8 0.4 ART4 "ARTC4, CD297, DO, DOK1" ENSG00000111339 "ADP-ribosyltransferase 4 (inactive) (Dombrock blood group)" Q93070 12 14825569-14843526 "Blood group antigen proteins, CD markers, Enzymes, Metabolic proteins, Predicted membrane proteins, Predicted secreted proteins" "Blood group antigen, Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 53.3;lymphoid tissue: 19.0" "Cell type enhanced" "Detected in some" "Cholangiocytes: 15.7;Endothelial cells: 12.9;Erythroid cells: 51.3;Hepatic stellate cells: 66.0;Hepatocytes: 30.2" "Group enriched" "Detected in some" 5 "liver cancer: 3.8;pancreatic cancer: 1.0" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AN3-CA: 6.0;HEL: 12.1;Hep G2: 7.3;HUVEC TERT2: 27.0" "Region enhanced" "Detected in single" "olfactory bulb: 1.8" "Low region specificity" "Detected in all" HPA075664 Approved "Rods & Rings" "Secreted to blood" NA NA 17000000 "Cluster 85: Liver - Metabolism" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 6: Erythroid cells - Oxygen transport" "Rods & Rings" "HPA075664: " "unprognostic (2.50e-2)" "unprognostic (1.12e-1)" "unprognostic (1.57e-1)" "unprognostic (1.18e-2)" "unprognostic (1.55e-1)" "unprognostic (1.37e-2)" "unprognostic (1.92e-1)" "unprognostic (1.90e-2)" "unprognostic (1.10e-1)" "unprognostic (2.64e-1)" "unprognostic (1.37e-1)" "unprognostic (1.90e-2)" "unprognostic (2.62e-3)" "unprognostic (4.33e-3)" "unprognostic (1.25e-3)" "unprognostic (1.05e-1)" "unprognostic (1.71e-1)" 2.6 2.7 0.3 1.1 0.5 4.6 1.8 0.1 0.4 0.9 0.4 0.6 0.0 0.8 0.3 0.9 2.1 9.0 9.0 0.3 1.1 3.6 53.3 3.2 8.6 0.5 0.4 0.5 2.3 0.3 0.1 7.0 0.4 0.3 0.5 0.3 0.7 0.4 0.3 0.3 0.6 1.1 0.2 19.0 0.3 0.2 0.4 1.9 3.6 0.2 2.3 0.6 0.5 0.6 0.0 0.0 0.2 6.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.1 0.0 7.3 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 27.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.6 0.2 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.5 0.1 0.4 0.3 1.1 0.5 0.4 0.4 0.2 0.4 0.6 0.7 0.0 1.1 0.7 0.2 0.3 0.8 0.0 0.0 2.4 0.2 0.1 1.5 15.7 0.0 1.8 12.5 0.9 0.1 0.0 0.0 0.9 0.4 0.2 0.1 12.9 0.0 51.3 0.2 1.9 2.5 1.9 0.0 0.1 0.0 0.0 66.0 30.2 0.1 0.0 0.2 0.0 0.0 4.7 1.3 0.3 1.8 0.1 1.8 0.0 0.0 0.3 1.0 0.0 0.3 0.6 0.0 0.0 0.0 0.2 0.0 0.2 0.0 11.8 6.6 0.5 1.2 0.1 0.1 0.0 0.1 0.3 0.2 0.0 0.0 0.4 ART5 ARTC5 ENSG00000167311 "ADP-ribosyltransferase 5" Q96L15 11 3638512-3642316 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 13.4;testis: 29.4" "Group enriched" "Detected in some" 8 "Early spermatids: 18.3;Late spermatids: 18.5;Spermatocytes: 64.9" "Cancer enriched" "Detected in some" 4 "testis cancer: 4.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 4 "SuSa: 13.9" "Not detected" "Not detected" "HPA041637, HPA044099" Uncertain "Secreted in other tissues" NA NA "Cluster 23: Testis - Cell cycle regulation" "Cluster 12: NES - Nervous system development" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA041637: AB_2677589, HPA044099: AB_2678808" "unprognostic (6.32e-2)" "unprognostic (3.26e-5)" "unprognostic (4.09e-3)" "unprognostic (2.06e-4)" "unprognostic (1.53e-2)" "unprognostic (1.47e-2)" "unprognostic (2.22e-2)" "unprognostic (1.21e-2)" "unprognostic (5.65e-2)" "unprognostic (2.59e-2)" "unprognostic (1.17e-1)" "unprognostic (1.67e-1)" "prognostic favorable (1.85e-4)" "unprognostic (3.10e-3)" "unprognostic (3.46e-2)" "unprognostic (1.96e-1)" "unprognostic (3.18e-1)" 0.7 0.2 0.3 0.0 0.3 0.0 1.0 0.3 0.5 4.1 0.6 0.3 0.0 3.6 0.7 0.5 1.5 1.4 1.8 0.3 0.8 0.8 0.9 0.9 0.1 0.4 0.4 8.3 0.4 2.9 0.7 0.1 0.6 1.1 0.0 0.6 1.6 0.9 13.4 0.5 0.2 1.1 0.3 0.0 0.5 29.4 0.4 0.3 2.8 10.5 0.0 0.7 2.2 0.3 0.0 0.1 1.6 2.0 0.0 0.0 3.2 0.2 1.6 0.7 1.8 0.0 0.0 0.0 0.8 0.2 0.0 0.0 1.5 0.0 0.4 0.0 2.2 0.0 0.3 0.1 0.0 0.0 1.4 0.5 0.0 0.0 0.0 0.2 0.0 0.1 0.6 0.0 0.2 0.3 0.0 0.0 1.5 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 1.5 0.0 13.9 0.5 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.3 0.5 0.3 0.8 0.4 0.4 0.6 0.3 0.4 0.3 0.1 0.0 1.8 0.0 0.0 0.3 2.2 0.0 2.8 0.8 0.3 1.3 2.5 0.0 0.6 0.0 0.0 0.6 0.0 0.1 0.0 0.6 18.3 0.1 0.2 0.4 0.0 0.0 0.0 0.2 0.5 1.3 0.0 0.2 0.0 3.3 0.0 1.8 0.1 0.0 0.0 0.2 0.0 0.3 0.0 18.5 3.4 0.1 0.0 1.0 0.0 3.6 0.0 0.0 0.0 0.2 0.0 1.2 0.1 0.8 0.0 0.6 0.0 0.9 0.0 1.3 0.2 64.9 3.9 0.1 0.3 2.9 0.0 1.2 0.0 0.3 AS3MT CYT19 ENSG00000214435 "Arsenite methyltransferase" Q9HBK9 10 102869470-102901899 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "adrenal gland: 302.4" "Cell type enhanced" "Detected in some" "Alveolar cells type 2: 1.1;Basal squamous epithelial cells: 1.2;Proximal tubular cells: 1.0" "Cancer enhanced" "Detected in single" "liver cancer: 1.0" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 26.8;REH: 54.6;SH-SY5Y: 27.8;T-47d: 43.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017856 Enhanced Approved Mitochondria NA NA "Cluster 17: Adrenal gland - Steroid metabolism" "Cluster 6: T47d - Mammary gland" "Cluster 50: Fibroblasts - ECM organization" Mitochondria "HPA017856: AB_1847420" "unprognostic (1.11e-1)" "unprognostic (2.02e-4)" "unprognostic (2.45e-1)" "unprognostic (2.25e-1)" "unprognostic (3.39e-1)" "unprognostic (1.66e-1)" "unprognostic (7.02e-4)" "unprognostic (3.22e-1)" "unprognostic (1.42e-1)" "unprognostic (3.90e-2)" "unprognostic (2.03e-1)" "unprognostic (1.83e-1)" "unprognostic (3.83e-10)" "unprognostic (1.04e-2)" "unprognostic (4.17e-2)" "unprognostic (1.59e-1)" "unprognostic (2.16e-2)" 5.1 302.4 7.4 1.3 7.5 0.7 6.3 11.5 8.7 7.5 9.3 6.4 3.0 7.7 4.4 3.6 5.8 6.7 26.8 6.7 8.4 19.2 59.2 4.0 2.0 7.9 8.3 8.7 11.7 65.7 6.6 1.0 8.0 9.1 1.8 4.8 4.8 5.2 11.4 4.3 3.3 3.9 6.6 18.3 4.7 8.7 7.7 3.7 7.7 15.2 1.6 3.2 5.0 8.3 0.0 7.6 26.8 17.4 0.6 0.6 5.1 8.1 6.7 11.9 14.3 21.3 1.2 0.0 2.4 10.7 0.6 0.4 23.8 1.4 12.4 0.3 6.7 0.0 3.2 20.9 7.7 0.2 0.6 3.7 3.1 1.6 0.0 21.3 0.5 25.3 0.0 0.4 10.8 0.1 4.9 0.7 13.2 0.1 1.0 54.6 0.0 0.2 2.7 0.0 0.4 27.8 0.0 0.4 3.7 8.8 43.9 0.6 0.1 2.6 0.0 3.9 0.0 0.2 0.4 0.0 8.6 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 7.4 7.5 11.5 8.7 6.7 8.4 7.9 8.3 8.0 6.6 7.7 8.3 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.3 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.4 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.3 0.0 0.0 ASH1L "ASH1, ASH1L1, huASH1, KMT2H" ENSG00000116539 "ASH1 like histone lysine methyltransferase" Q9NR48 1 155335268-155563162 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Transcription, Transcription regulation" "Activator, Chromatin regulator, Methyltransferase, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA004806 Approved Supported "Nucleoplasm,Golgi apparatus" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 80: Striated muscle - Unknown function" "Cluster 43: THP-1 - Innate immune response" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Golgi apparatus" "HPA004806: AB_1845087" "unprognostic (2.98e-1)" "unprognostic (3.15e-2)" "unprognostic (1.10e-1)" "unprognostic (1.70e-2)" "unprognostic (2.05e-2)" "unprognostic (4.75e-2)" "unprognostic (1.42e-1)" "unprognostic (1.87e-2)" "unprognostic (1.46e-1)" "unprognostic (1.59e-1)" "unprognostic (1.07e-1)" "unprognostic (6.84e-2)" "prognostic favorable (3.80e-4)" "unprognostic (2.95e-1)" "unprognostic (1.62e-1)" "unprognostic (2.45e-2)" "unprognostic (1.94e-1)" 14.1 12.8 21.3 8.5 23.4 11.9 16.8 27.0 25.7 14.4 14.8 13.0 9.7 14.4 20.8 9.2 11.4 9.0 12.6 23.8 19.2 13.9 10.0 10.3 10.9 18.7 19.8 21.3 9.9 18.2 8.4 10.3 18.9 15.7 11.5 26.2 14.8 15.4 30.3 20.4 10.2 12.7 19.3 10.5 11.9 6.8 20.7 12.1 15.8 24.3 9.7 11.7 10.0 23.4 17.2 12.3 9.5 9.4 28.0 22.8 9.6 14.7 13.5 8.3 6.5 10.5 12.3 5.4 14.2 17.0 5.4 19.2 13.6 12.6 13.6 7.6 8.9 8.0 13.2 9.8 14.5 8.8 6.6 16.2 18.0 13.6 15.0 17.1 11.0 6.0 12.3 8.3 18.8 19.0 6.4 8.8 8.3 28.8 13.1 6.1 18.5 10.4 18.6 16.0 9.1 14.3 20.1 25.9 12.9 9.3 16.6 26.6 17.4 13.6 15.8 13.4 17.9 8.0 5.3 8.9 10.7 9.1 13.1 1.0 0.4 0.8 0.7 0.2 0.5 0.9 0.5 0.5 0.2 0.8 0.8 0.5 1.0 0.6 0.1 0.7 0.9 0.2 21.3 23.4 27.0 25.7 23.8 19.2 18.7 19.8 18.9 19.3 20.7 23.4 96.5 60.9 103.2 171.7 108.3 103.9 97.4 52.9 109.3 147.6 75.9 58.3 107.8 50.1 82.7 51.5 202.3 53.6 83.3 76.2 17.6 41.5 25.9 72.0 107.4 77.6 67.5 46.7 220.6 39.8 25.2 93.7 101.4 87.9 81.1 72.3 63.1 39.0 24.6 114.4 211.8 59.0 26.4 42.1 106.9 22.8 102.2 69.1 53.4 203.3 85.2 68.4 89.6 190.5 265.0 37.5 64.8 118.8 110.1 112.0 68.9 31.0 47.1 116.7 98.6 134.4 104.6 85.6 56.1 80.9 112.0 76.2 98.7 87.3 60.2 111.6 ASMT "ASMTY, HIOMT, HIOMTY" ENSG00000196433 "Acetylserotonin O-methyltransferase" P46597 X 1615059-1643081 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Melatonin biosynthesis" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in some" "Cell type enhanced" "Detected in some" "Alveolar cells type 2: 1.8;Early spermatids: 1.1;Excitatory neurons: 1.5;Extravillous trophoblasts: 1.0;Inhibitory neurons: 1.3;Oligodendrocytes: 1.3;Theca cells: 3.4" "Not detected" "Not detected" "Low region specificity" "Detected in single" "Immune cell enhanced" "Detected in single" "naive B-cell: 2.1" "Low lineage specificity" "Detected in single" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 24: B-cells - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 10: Non-specific - Unknown function" "unprognostic (1.84e-2)" "unprognostic (1.63e-3)" "unprognostic (1.89e-1)" "unprognostic (1.40e-1)" "unprognostic (3.02e-1)" "unprognostic (8.55e-4)" "unprognostic (1.54e-1)" "unprognostic (2.27e-2)" "unprognostic (4.30e-3)" "unprognostic (1.56e-1)" "unprognostic (1.43e-3)" "unprognostic (2.64e-1)" "unprognostic (4.04e-3)" "unprognostic (1.49e-1)" "unprognostic (3.27e-2)" "unprognostic (2.23e-1)" "unprognostic (2.79e-3)" 0.4 0.8 0.6 0.3 0.6 0.7 0.4 0.6 0.9 0.8 1.4 0.5 0.0 0.6 1.8 0.2 0.5 0.2 0.4 0.6 1.1 0.3 0.3 0.3 0.2 0.4 0.4 0.4 0.4 0.1 1.4 0.1 0.4 0.5 0.0 0.4 0.3 0.2 0.2 0.4 0.4 0.2 0.3 0.6 0.4 0.4 0.5 0.1 0.5 0.1 0.1 0.5 0.4 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.5 0.9 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.6 0.0 2.1 0.0 0.0 0.1 0.4 0.0 0.0 0.0 0.0 0.6 0.6 0.6 0.9 0.6 1.1 0.4 0.4 0.4 0.3 0.5 0.6 0.2 0.0 1.8 0.3 0.6 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 1.1 0.0 0.1 0.2 0.0 0.0 1.5 0.0 1.0 0.1 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 1.3 0.0 0.0 0.0 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.2 0.2 0.0 0.0 0.1 0.5 3.4 0.0 0.1 ATAT1 "C6orf134, Em:AB023049.7, FLJ13158, MEC17" ENSG00000137343 "Alpha tubulin acetyltransferase 1" Q5SQI0 6 30626842-30646823 "Enzymes, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Early spermatids: 87.6;Late spermatids: 42.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 8.0;AN3-CA: 5.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA046816, HPA050999" Approved Approved "Golgi apparatus,Cytosol" "Intracellular and membrane" No No "Cluster 46: Basophils - DNA binding" "Cluster 71: Testis - DNA repair" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 23: Spermatids - Flagellum & Golgi organization" "Golgi apparatus, Cytosol" "HPA046816: AB_2679822, HPA050999: AB_2681303" "unprognostic (3.98e-1)" "unprognostic (3.18e-1)" "unprognostic (4.30e-2)" "unprognostic (2.67e-2)" "unprognostic (8.86e-2)" "unprognostic (8.18e-3)" "prognostic unfavorable (1.03e-5)" "unprognostic (1.49e-2)" "unprognostic (5.39e-2)" "unprognostic (2.37e-2)" "unprognostic (1.29e-3)" "unprognostic (1.25e-2)" "prognostic unfavorable (7.78e-5)" "unprognostic (2.62e-2)" "unprognostic (1.51e-1)" "unprognostic (2.02e-1)" "prognostic favorable (1.35e-4)" 5.3 6.0 2.3 0.6 2.9 0.6 7.6 1.8 3.3 12.4 0.9 8.6 0.5 9.7 3.6 7.6 9.8 0.7 5.5 2.6 3.3 11.3 7.6 5.8 0.6 2.3 2.7 13.4 6.0 0.2 21.3 0.4 2.5 13.5 0.6 2.5 7.7 0.3 4.9 6.6 7.8 0.7 1.9 5.6 7.4 13.5 2.5 0.7 9.3 0.0 0.7 9.2 8.4 3.1 1.4 0.7 8.0 5.3 0.9 0.7 0.6 0.3 0.0 0.2 0.4 2.3 1.4 0.1 1.1 1.1 2.2 1.5 2.5 0.9 0.0 1.0 4.2 0.1 0.1 2.6 0.4 0.5 1.1 1.4 0.5 0.3 0.0 1.0 0.5 3.8 1.5 0.0 1.3 1.5 1.0 0.3 0.4 2.2 0.0 1.0 0.1 0.4 1.3 2.4 0.3 3.2 0.6 0.6 0.4 0.0 2.9 0.4 1.0 3.0 1.3 0.0 0.5 0.9 2.5 0.8 1.6 3.4 2.1 0.5 0.4 0.3 0.1 0.3 0.1 0.5 0.2 0.1 0.4 0.2 0.4 0.4 0.3 0.1 0.2 0.5 0.1 0.1 2.3 2.9 1.8 3.3 2.6 3.3 2.3 2.7 2.5 1.9 2.5 3.1 6.2 0.0 1.5 14.7 6.4 5.6 14.0 16.9 14.2 9.0 9.4 11.4 1.9 5.7 8.6 14.7 10.4 11.9 4.1 7.6 7.9 11.9 87.6 9.0 7.7 7.9 18.0 3.0 7.8 4.5 6.3 6.9 8.2 8.0 1.3 16.0 3.3 2.9 6.1 1.7 11.4 8.9 14.2 1.6 3.1 42.4 4.1 3.1 0.0 5.6 9.1 12.5 6.2 16.6 13.1 9.3 10.8 8.6 4.1 11.6 9.7 5.4 10.8 10.7 6.6 8.0 7.8 12.4 11.8 8.0 5.4 8.9 4.7 6.1 11.1 15.3 ATE1 ENSG00000107669 "Arginyltransferase 1" O95260 10 121740424-121928492 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Oligodendrocyte precursor cells: 137.7;Oligodendrocytes: 220.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038444, HPA057549" Approved Supported Nucleoplasm NA NA 83000 "Cluster 18: Basophils - Vesicular transport" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "HPA038444: AB_10672745, HPA057549: AB_2683463" "unprognostic (1.37e-1)" "unprognostic (5.19e-2)" "unprognostic (2.75e-3)" "unprognostic (2.40e-1)" "unprognostic (4.67e-2)" "unprognostic (6.65e-3)" "unprognostic (1.85e-1)" "unprognostic (1.42e-1)" "unprognostic (1.71e-1)" "unprognostic (1.00e-1)" "unprognostic (2.52e-1)" "unprognostic (5.69e-2)" "prognostic favorable (2.67e-4)" "unprognostic (3.20e-1)" "unprognostic (8.08e-2)" "unprognostic (2.16e-1)" "unprognostic (1.02e-1)" 10.1 11.7 8.1 8.5 8.5 7.4 10.4 7.3 9.2 12.1 17.3 13.5 11.4 10.6 8.4 10.7 9.0 10.4 22.2 8.4 11.0 18.2 18.2 9.5 9.5 6.7 7.3 10.0 6.2 15.4 4.8 11.0 7.5 12.7 14.6 15.6 7.8 10.0 18.3 6.7 11.1 11.7 7.4 10.4 8.8 13.3 10.6 13.0 16.0 15.4 10.6 12.7 6.6 8.7 13.0 19.5 15.4 15.0 15.1 16.8 12.3 12.0 24.0 13.1 13.2 23.6 19.1 16.1 9.5 14.3 8.8 16.1 14.5 14.2 16.3 20.3 13.1 5.8 8.8 31.1 15.5 26.7 13.4 11.9 15.2 13.8 32.0 19.3 18.7 9.0 7.8 29.4 14.5 7.9 14.0 15.2 7.5 19.6 11.4 13.1 18.1 10.6 23.4 11.2 4.8 19.4 17.2 12.9 28.2 11.3 8.9 9.2 19.2 8.2 7.0 12.5 21.1 28.0 33.6 12.0 12.6 20.6 7.4 12.8 3.8 6.1 5.3 4.5 6.3 4.5 5.0 5.3 3.4 4.2 5.5 5.6 2.3 5.1 3.5 4.8 6.7 4.0 8.1 8.5 7.3 9.2 8.4 11.0 6.7 7.3 7.5 7.4 10.6 8.7 23.0 9.6 22.0 76.4 17.3 8.4 12.8 9.4 24.5 31.3 17.5 14.6 75.6 11.5 12.7 20.2 12.5 7.2 20.9 42.8 17.6 11.3 6.5 15.8 19.4 19.3 22.1 16.2 100.5 13.3 10.5 25.0 29.6 16.4 12.6 13.5 20.0 26.6 10.0 23.5 93.8 17.7 10.2 14.8 7.2 7.7 20.5 23.6 14.2 74.0 12.8 21.7 27.8 137.7 220.4 15.6 18.3 25.9 24.8 21.0 19.5 39.4 11.5 35.8 0.0 23.4 21.1 26.9 40.2 30.7 17.5 8.6 17.9 29.1 16.8 16.6 ATIC "AICARFT, IMPCHASE, PURH" ENSG00000138363 "5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase" P31939 2 215311956-215349773 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Purine biosynthesis" "Hydrolase, Multifunctional enzyme, Transferase" "Cancer-related genes, Disease variant, Epilepsy, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 171.4;Extravillous trophoblasts: 166.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB013462, HPA021012" Supported Approved "Plasma membrane,Cytosol" NA NA 3900000 "Cluster 44: Non-specific - Transcription" "Cluster 3: T-cells - Adaptive immune response" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 38: Extravillous trophoblasts - Unknown function" Cytosol "Plasma membrane" "CAB013462: , HPA021012: AB_1845169" "unprognostic (1.41e-2)" "unprognostic (2.18e-1)" "unprognostic (1.13e-2)" "unprognostic (8.46e-2)" "unprognostic (2.90e-1)" "unprognostic (3.81e-2)" "prognostic unfavorable (1.99e-7)" "unprognostic (1.86e-2)" "unprognostic (5.07e-2)" "unprognostic (1.83e-1)" "unprognostic (6.31e-3)" "unprognostic (9.21e-2)" "prognostic unfavorable (8.77e-4)" "unprognostic (1.00e-1)" "unprognostic (1.30e-1)" "unprognostic (4.18e-2)" "unprognostic (4.39e-3)" 24.8 26.0 19.8 31.7 23.4 26.4 33.9 21.4 23.5 22.2 18.8 36.4 32.0 30.0 20.3 19.4 29.4 20.4 21.3 19.6 21.5 32.7 34.6 18.0 44.9 20.5 21.5 32.0 26.2 29.6 18.6 37.3 23.3 28.7 47.5 19.1 18.8 38.4 43.2 23.8 27.2 37.0 21.0 27.6 24.5 20.1 22.9 41.8 22.5 25.4 51.8 29.1 17.6 27.5 102.2 133.8 85.1 144.0 112.5 113.2 40.6 105.4 91.9 117.4 134.9 278.6 157.3 149.6 122.8 110.0 164.5 106.7 187.8 157.0 169.5 113.4 189.3 179.1 108.7 271.5 145.4 226.1 92.0 98.4 119.8 154.7 188.5 82.0 79.7 144.5 237.0 124.4 166.3 178.7 203.4 112.1 330.3 167.4 84.9 185.8 117.3 133.4 126.4 146.5 129.3 87.8 84.3 103.1 124.3 189.2 169.7 82.9 70.2 96.0 101.2 127.3 65.8 160.3 195.7 300.1 85.6 124.5 146.8 12.6 16.4 0.4 34.6 23.5 59.1 56.6 49.0 53.8 36.3 39.9 50.0 46.9 1.8 55.4 21.1 31.7 50.2 29.0 19.8 23.4 21.4 23.5 19.6 21.5 20.5 21.5 23.3 21.0 22.9 27.5 7.2 12.8 19.3 18.6 34.7 15.0 28.2 55.0 30.7 10.0 18.2 16.1 21.1 28.6 33.3 23.9 4.2 171.4 23.3 17.6 27.4 45.2 1.1 20.7 28.2 6.1 19.2 32.2 15.4 49.3 166.3 25.3 22.4 20.8 25.3 32.9 5.3 22.2 52.4 10.1 15.4 33.8 26.4 14.4 10.8 1.7 23.9 20.2 30.2 2.8 26.1 21.3 26.8 16.6 25.7 32.4 28.5 34.3 36.3 24.0 18.8 52.7 27.3 14.7 26.3 19.2 29.0 3.3 43.8 24.6 8.5 95.4 29.8 40.7 58.4 18.1 ATM "ATA, ATC, ATD, ATDC, TEL1, TELO1" ENSG00000149311 "ATM serine/threonine kinase" Q13315 11 108222832-108369102 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, DNA damage" "DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Neurodegeneration, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 210.6;NK-cells: 339.8;Oligodendrocytes: 217.6;Rod photoreceptor cells: 200.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-698: 78.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000102, HPA067142" Supported Supported Nucleoplasm,Vesicles NA NA "Cluster 44: Non-specific - Transcription" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 63: NK-cells & T-cells - Immune response" Nucleoplasm Vesicles "CAB000102: , HPA067142: AB_2685789" "unprognostic (9.77e-2)" "unprognostic (1.47e-1)" "unprognostic (3.04e-1)" "unprognostic (2.36e-1)" "unprognostic (5.70e-2)" "unprognostic (2.86e-2)" "unprognostic (6.32e-3)" "unprognostic (1.05e-1)" "unprognostic (8.19e-2)" "unprognostic (1.63e-1)" "unprognostic (7.68e-2)" "unprognostic (6.16e-2)" "unprognostic (2.17e-3)" "unprognostic (3.10e-1)" "unprognostic (7.87e-2)" "unprognostic (1.21e-1)" "unprognostic (2.81e-1)" 6.2 7.4 8.2 17.5 15.0 16.2 8.5 17.0 12.3 8.7 16.1 6.7 5.2 10.0 9.9 4.0 7.5 8.2 7.0 7.3 11.3 5.8 7.8 7.6 33.7 15.8 13.1 15.8 14.8 9.3 12.1 8.0 17.0 6.3 7.0 20.6 11.4 6.1 4.4 7.5 12.6 6.9 10.3 22.2 8.6 5.2 12.7 18.2 8.8 6.0 25.9 7.1 6.9 28.8 4.3 6.8 14.8 7.6 20.2 29.1 3.1 10.9 13.5 6.4 11.3 7.1 10.3 18.3 14.0 10.2 9.6 7.7 11.6 10.8 9.0 12.3 5.7 15.2 8.7 10.2 10.5 16.4 17.0 18.3 6.3 10.0 21.2 15.2 14.1 16.5 12.4 9.9 14.3 3.4 10.6 18.5 9.8 8.6 7.4 9.7 9.7 24.9 8.1 7.5 9.0 10.5 11.1 4.7 20.6 13.2 9.3 10.1 23.7 15.8 8.4 7.3 9.0 6.2 7.0 78.3 7.0 19.0 18.8 21.3 5.5 4.0 16.5 5.7 11.1 11.6 11.7 12.5 2.6 13.0 21.1 20.4 9.9 9.7 13.3 6.2 6.1 5.3 8.2 15.0 17.0 12.3 7.3 11.3 15.8 13.1 17.0 10.3 12.7 28.8 23.7 38.5 20.8 62.7 146.4 12.6 17.5 21.1 28.5 111.0 19.6 14.2 39.9 12.8 19.5 22.0 210.6 16.9 140.2 4.2 5.9 9.9 19.2 14.4 52.1 25.9 20.4 39.1 70.2 12.3 13.2 39.0 12.8 20.9 13.3 45.9 32.9 23.3 29.1 60.6 82.8 14.9 26.4 96.4 34.0 5.1 39.4 69.2 26.6 178.9 63.2 27.3 339.8 85.5 217.6 7.6 7.6 27.8 96.5 9.1 8.9 11.1 16.0 200.1 26.3 41.4 29.2 31.5 37.4 15.8 12.4 4.2 147.7 52.3 11.5 10.2 ATR "FRP1, MEC1, SCKL, SCKL1" ENSG00000175054 "ATR serine/threonine kinase" Q13535 3 142449007-142578733 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "DNA damage, DNA repair" "DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Dwarfism, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 93.0;Inhibitory neurons: 94.4;Microglial cells: 73.1;Oligodendrocyte precursor cells: 65.4;Oligodendrocytes: 71.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA054320 Supported "Nucleoplasm,Golgi apparatus" No No "Cluster 15: NK-cells - Transcription" "Cluster 17: Adrenal gland - Steroid metabolism" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "Golgi apparatus" "HPA054320: AB_2682448" "unprognostic (1.47e-1)" "unprognostic (8.90e-2)" "unprognostic (2.90e-1)" "unprognostic (4.23e-2)" "unprognostic (2.25e-2)" "unprognostic (6.42e-2)" "prognostic unfavorable (8.39e-5)" "unprognostic (3.44e-1)" "unprognostic (1.67e-1)" "unprognostic (3.02e-1)" "prognostic unfavorable (1.23e-5)" "unprognostic (1.94e-1)" "unprognostic (5.61e-2)" "unprognostic (1.06e-1)" "unprognostic (3.55e-1)" "unprognostic (1.69e-2)" "unprognostic (1.43e-1)" 3.0 8.6 0.7 4.1 1.1 1.2 3.2 0.9 1.4 3.8 3.7 2.7 1.7 3.3 2.3 3.1 3.3 3.4 2.3 1.2 1.9 3.7 3.6 2.9 4.8 1.5 1.2 2.7 3.8 5.2 3.7 3.1 1.4 3.0 2.9 2.9 3.5 2.5 2.9 2.7 3.1 3.2 1.0 4.2 2.8 5.2 1.2 4.9 5.0 1.4 4.6 4.1 2.7 1.2 28.6 13.2 7.1 7.0 9.6 13.6 8.8 14.8 8.4 10.1 9.7 6.4 6.8 19.9 14.6 10.1 14.6 16.1 10.9 12.8 15.0 7.5 7.9 11.9 8.2 4.1 4.2 20.5 5.3 9.8 4.8 9.5 10.3 5.8 11.6 8.7 8.2 7.5 9.6 7.5 13.9 2.6 7.3 15.6 9.6 11.8 12.5 13.5 6.3 11.1 5.2 5.1 28.6 8.3 8.0 7.8 12.0 5.4 14.6 10.5 4.9 12.3 15.2 10.8 7.4 18.5 13.8 6.5 8.5 0.0 0.3 0.0 0.5 0.4 1.0 0.1 0.3 0.5 0.7 0.3 0.4 0.4 0.0 1.3 0.2 0.2 0.4 0.2 0.7 1.1 0.9 1.4 1.2 1.9 1.5 1.2 1.4 1.0 1.2 1.2 11.5 6.4 10.6 39.2 22.4 4.0 7.2 8.8 14.2 14.1 9.2 6.5 7.6 5.7 10.1 3.7 37.5 7.7 14.9 3.5 0.0 5.9 16.4 18.8 18.6 10.2 7.7 14.5 93.0 4.9 3.6 8.3 14.8 10.3 1.3 16.3 7.9 7.3 6.4 8.4 94.4 4.8 14.2 9.4 4.0 8.7 6.5 12.8 10.6 73.1 12.0 6.0 9.2 65.4 71.9 6.4 1.8 7.2 23.1 8.1 1.9 6.5 25.4 23.6 0.0 14.6 9.8 50.1 18.5 14.7 4.5 5.1 15.1 13.8 7.6 6.1 AURKA "AIK, ARK1, AurA, BTAK, PPP1R47, STK15, STK6, STK7" ENSG00000087586 "Aurora kinase A" O14965 20 56369389-56392337 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Cilium biogenesis/degradation, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 22.1;testis: 30.8" "Cell type enhanced" "Detected in many" "Erythroid cells: 81.6;Extravillous trophoblasts: 67.1;granulocytes: 54.1;Spermatocytes: 168.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "CAB001454, HPA002636" Enhanced Approved "Nucleoplasm,Mitotic spindle,Centrosome,Cytosol" Yes Yes "Cluster 7: Monocytes - Unknown function" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" "Nucleoplasm, Centrosome" "Mitotic spindle, Cytosol" "CAB001454: AB_563420, HPA002636: AB_1845217" "unprognostic (7.73e-2)" "unprognostic (2.46e-2)" "unprognostic (2.76e-2)" "prognostic unfavorable (9.40e-5)" "unprognostic (1.92e-1)" "unprognostic (2.11e-2)" "prognostic unfavorable (1.49e-4)" "unprognostic (4.69e-3)" "unprognostic (2.42e-1)" "unprognostic (6.88e-2)" "prognostic unfavorable (6.13e-4)" "unprognostic (1.40e-1)" "prognostic unfavorable (1.47e-8)" "unprognostic (1.67e-1)" "unprognostic (6.83e-2)" "unprognostic (9.00e-2)" "unprognostic (5.14e-2)" 1.3 2.3 1.3 10.4 1.6 15.3 2.2 2.4 1.4 1.4 0.6 10.8 11.7 1.5 0.8 7.5 1.2 2.0 5.3 0.8 1.0 2.3 5.0 2.2 20.9 1.7 1.2 8.4 2.0 1.8 0.6 8.1 1.4 1.1 12.9 3.0 1.9 1.3 8.7 3.5 9.3 4.9 1.3 5.2 4.9 30.8 1.6 20.2 1.4 8.2 22.1 2.9 2.6 1.3 179.9 127.2 84.5 61.2 4.9 10.8 106.3 145.2 66.8 339.7 142.9 361.4 124.8 58.4 96.2 59.2 176.2 142.2 152.4 96.4 360.0 52.4 57.5 102.6 128.9 229.8 2.8 140.4 140.4 5.1 10.1 117.3 104.5 26.7 80.7 93.2 121.8 45.3 146.9 182.1 85.3 108.9 78.3 145.6 129.8 62.9 163.4 65.9 56.0 46.8 73.9 39.6 200.5 228.8 94.2 77.3 137.9 86.1 47.1 149.7 145.3 83.0 208.6 62.3 78.9 100.5 80.5 80.9 127.0 0.2 3.5 4.3 1.2 5.9 1.8 2.5 2.0 1.1 3.7 0.8 0.9 0.9 2.3 1.4 3.4 0.8 4.7 1.7 1.3 1.6 2.4 1.4 0.8 1.0 1.7 1.2 1.4 1.3 1.6 1.3 2.5 0.0 2.8 0.3 7.4 1.1 1.2 5.6 0.6 1.0 4.3 6.2 5.6 1.5 2.3 3.7 2.1 34.5 8.3 8.3 1.9 4.0 33.9 2.0 2.3 3.1 6.0 81.6 1.1 4.9 67.1 7.0 13.7 3.4 54.1 12.3 3.6 2.6 17.5 1.7 1.5 10.8 2.0 3.5 7.6 16.3 1.5 11.7 0.0 1.0 12.0 3.7 3.1 1.0 2.0 5.2 2.8 0.4 10.1 2.0 5.1 4.2 1.5 2.7 6.6 2.2 7.7 168.2 30.8 8.3 1.1 8.2 8.0 8.7 15.5 1.5 AURKB "Aik2, AIM-1, ARK2, AurB, IPL1, PPP1R48, STK12, STK5" ENSG00000178999 "Aurora kinase B" Q96GD4 17 8204733-8210600 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 44.1;lymphoid tissue: 60.1" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 40.5;Erythroid cells: 59.3;Extravillous trophoblasts: 89.1;Granulosa cells: 24.7;Hofbauer cells: 29.4" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Immune cell enhanced" "Detected in some" "T-reg: 7.9" "Group enriched" "Detected in many" 6 "B-cells: 2.5;T-cells: 7.9" "Low cell line specificity" "Detected in many" "Group enriched" "Detected in some" 5 "basal ganglia: 1.3;white matter: 4.0" "Low region specificity" "Detected in all" "CAB005862, HPA037708" Enhanced Enhanced Nucleoplasm,Midbody Yes Yes "Cluster 4: T-regs - Cell cycle regulation" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm Midbody "CAB005862: AB_449204, HPA037708: AB_2675623" "unprognostic (4.76e-2)" "unprognostic (3.61e-3)" "unprognostic (2.25e-1)" "unprognostic (3.14e-2)" "unprognostic (2.27e-1)" "unprognostic (6.05e-2)" "prognostic unfavorable (1.24e-4)" "unprognostic (1.99e-3)" "unprognostic (9.41e-3)" "unprognostic (3.47e-2)" "unprognostic (4.61e-3)" "unprognostic (1.01e-2)" "prognostic unfavorable (0.00e+0)" "unprognostic (7.77e-2)" "unprognostic (2.93e-1)" "unprognostic (6.76e-2)" "unprognostic (3.77e-1)" 1.1 1.2 0.1 14.2 0.2 44.1 1.7 0.2 0.2 3.0 0.1 11.1 12.1 1.6 0.4 18.6 0.6 1.5 0.7 0.1 0.2 0.9 2.0 2.5 36.7 0.1 0.3 0.5 0.6 0.3 0.2 8.2 0.3 0.8 11.0 0.0 2.7 0.3 5.5 9.3 11.6 3.2 0.0 12.0 4.6 1.2 0.4 60.1 0.6 0.0 36.6 3.5 5.9 0.2 196.5 130.9 191.1 93.0 4.2 6.5 73.4 91.7 49.5 186.2 170.6 171.5 57.4 193.3 46.2 37.0 77.0 139.8 140.1 62.6 153.7 84.9 231.3 115.7 78.3 146.1 0.7 62.2 109.2 3.5 2.9 109.4 67.7 18.5 86.5 123.6 73.3 73.4 82.9 92.9 225.1 87.4 119.6 63.9 57.6 149.8 176.1 80.5 41.2 38.2 41.2 59.1 81.7 36.5 61.2 56.5 63.5 41.4 33.9 74.3 75.6 67.6 243.3 53.2 37.7 147.9 35.7 92.9 153.4 0.0 0.4 0.6 0.5 0.3 0.1 1.1 1.3 2.1 0.5 2.5 0.1 0.7 0.9 0.3 0.2 0.2 7.9 0.9 0.1 0.2 0.2 0.2 0.1 0.2 0.1 0.3 0.3 0.0 0.4 0.2 0.3 0.0 0.5 0.0 7.6 4.5 1.8 6.1 0.6 0.0 1.8 2.2 1.4 0.0 2.6 0.0 0.0 40.5 1.8 13.2 0.0 0.4 0.1 0.5 1.6 3.1 0.0 59.3 0.0 0.0 89.1 5.7 6.1 2.1 4.5 24.7 6.1 0.7 29.4 0.0 0.0 10.8 0.0 5.7 7.3 0.2 0.6 5.1 1.8 0.0 0.9 0.0 3.1 0.0 0.1 0.3 2.8 0.0 15.4 1.2 1.5 0.1 0.2 0.0 0.0 0.1 4.8 1.6 7.2 11.8 2.4 9.0 4.3 1.0 22.0 2.8 AURKC "ARK3, AurC, STK13" ENSG00000105146 "Aurora kinase C" Q9UQB9 19 57230802-57235548 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Meiosis, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 7 "testis: 46.9" "Group enriched" "Detected in many" 4 "Early spermatids: 150.2;Spermatocytes: 116.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 7 "NTERA-2: 38.4" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA034859 Uncertain NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 78: Testis - Spermatogenesis" "Cluster 5: NTERA-2 - Transcription" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA034859: AB_10670298" "unprognostic (7.27e-2)" "unprognostic (1.76e-1)" "unprognostic (6.45e-2)" "unprognostic (8.07e-3)" "unprognostic (3.29e-1)" "unprognostic (5.99e-2)" "unprognostic (1.11e-2)" "unprognostic (7.02e-2)" "unprognostic (1.13e-1)" "unprognostic (2.09e-1)" "unprognostic (1.47e-2)" "unprognostic (2.51e-1)" "unprognostic (1.20e-5)" "unprognostic (4.26e-2)" "unprognostic (1.61e-1)" "unprognostic (1.55e-1)" "unprognostic (6.46e-4)" 1.2 1.1 3.5 1.3 3.7 1.4 2.0 3.8 6.3 0.7 3.0 1.0 0.2 1.3 1.8 1.0 1.1 1.4 1.9 3.5 3.5 1.5 2.7 1.1 3.4 3.7 3.6 0.5 0.9 0.6 1.4 1.9 3.9 0.9 1.3 1.1 0.8 1.4 1.9 1.2 0.8 1.1 3.8 5.0 0.8 46.9 3.7 1.2 1.2 0.5 2.2 1.4 0.8 4.3 0.3 0.1 0.9 0.4 0.3 0.9 0.5 1.7 0.8 1.2 4.4 1.3 0.2 0.1 0.2 0.6 1.0 0.0 0.0 0.9 0.8 0.0 4.9 0.2 0.4 0.0 1.4 0.0 0.3 1.2 0.9 0.9 0.7 1.5 0.8 0.5 0.2 0.0 1.6 0.0 1.5 0.9 38.4 0.2 1.0 0.1 0.3 0.8 0.9 1.7 1.9 0.6 0.0 0.3 0.2 0.1 0.1 1.8 0.4 0.3 5.1 0.4 1.0 1.9 2.7 0.8 1.1 0.0 0.1 0.0 0.0 0.4 0.1 0.2 0.0 0.3 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 3.5 3.7 3.8 6.3 3.5 3.5 3.7 3.6 3.9 3.8 3.7 4.3 1.9 0.0 0.5 0.7 0.1 1.1 0.8 0.9 0.0 2.4 1.2 3.8 1.2 0.0 2.5 1.8 0.0 0.4 0.9 0.7 1.9 2.1 150.2 0.8 0.4 0.8 1.8 0.4 1.3 1.0 0.9 1.0 0.0 0.6 0.0 0.5 1.8 0.6 4.1 0.0 1.3 0.3 0.0 2.6 0.8 28.9 1.5 1.2 5.4 0.0 1.0 1.8 1.0 0.0 0.9 1.3 1.4 0.4 0.6 1.3 0.0 0.5 2.7 1.0 6.6 0.4 0.7 116.8 22.9 0.5 1.1 0.3 0.9 0.5 0.4 1.6 AWAT1 DGAT2L3 ENSG00000204195 "Acyl-CoA wax alcohol acyltransferase 1" Q58HT5 X 70234655-70240659 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in single" "skin 1: 2.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA063412 Enhanced NA NA "Cluster 61: Skin - Cornification" "HPA063412: AB_2685009" "unprognostic (1.12e-1)" "unprognostic (1.78e-1)" "unprognostic (1.96e-2)" "unprognostic (4.90e-2)" "unprognostic (2.08e-1)" "unprognostic (6.78e-2)" 0.0 0.0 0.1 0.0 0.1 0.0 0.6 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 AWAT2 "DGAT2L4, MFAT" ENSG00000147160 "Acyl-CoA wax alcohol acyltransferase 2" Q6E213 X 70040542-70049938 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "skin 1: 11.2" "Cell type enriched" "Detected in some" 6 "Spermatocytes: 8.3" "Cancer enriched" "Detected in single" 7 "testis cancer: 0.6" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA062748 Approved NA NA "Cluster 61: Skin - Cornification" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" "HPA062748: AB_2684862" "unprognostic (3.41e-2)" "unprognostic (1.06e-1)" "unprognostic (2.99e-2)" "unprognostic (4.11e-2)" "unprognostic (1.11e-1)" "unprognostic (8.60e-2)" "unprognostic (4.55e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 11.2 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.2 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.1 8.3 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 AXL "ARK, JTK11, Tyro7, UFO" ENSG00000167601 "AXL receptor tyrosine kinase" P30530 19 41219223-41261766 "Disease related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Differentiation, Host-virus interaction, Immunity, Innate immunity" "Host cell receptor for virus entry, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "FDA approved drug targets, Oncogene, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Fibroblasts: 147.2;Kupffer cells: 187.5;Langerhans cells: 185.5;Prostatic glandular cells: 123.4;Sertoli cells: 210.4;Smooth muscle cells: 171.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "NK-cell: 11.1;plasmacytoid DC: 25.7" "Group enriched" "Detected in many" 12 "dendritic cells: 25.7;NK-cells: 11.1" "Cell line enhanced" "Detected in many" "fHDF/TERT166: 501.2;U-251 MG: 540.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB032501, HPA037422, HPA037423, HPA075217" Uncertain Supported "Vesicles,Plasma membrane,Actin filaments" NA Yes 12100000 72000000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 57: Non-specific - Angiogenesis" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 48: Smooth muscle cells - ECM organization" "Plasma membrane" "Vesicles, Actin filaments" "CAB032501: AB_2062572, HPA037422: AB_10672347, HPA037423: AB_2675470, HPA075217: " "unprognostic (2.20e-1)" "unprognostic (2.02e-1)" "unprognostic (6.79e-3)" "unprognostic (1.01e-1)" "unprognostic (1.40e-1)" "unprognostic (8.49e-3)" "unprognostic (2.42e-1)" "unprognostic (1.74e-1)" "unprognostic (3.15e-2)" "unprognostic (2.82e-2)" "unprognostic (9.57e-3)" "unprognostic (1.98e-1)" "prognostic unfavorable (2.53e-7)" "unprognostic (1.16e-3)" "unprognostic (1.52e-2)" "unprognostic (5.56e-2)" "unprognostic (4.83e-3)" 43.6 18.8 17.5 15.5 22.6 1.7 26.6 19.7 17.7 36.1 12.4 42.5 11.7 34.4 8.7 17.6 25.4 22.4 26.7 16.6 18.8 9.8 15.0 25.9 6.2 26.8 20.6 24.7 6.3 10.7 7.3 34.2 22.1 19.2 12.6 5.8 10.6 24.6 9.4 20.0 19.0 37.1 20.9 37.7 21.4 18.6 24.0 7.2 16.6 11.3 5.0 32.5 25.2 21.9 408.0 160.0 9.7 1.3 34.6 34.7 0.5 314.5 280.2 450.9 278.2 8.5 185.5 0.2 124.7 501.2 235.3 33.3 0.4 211.8 384.8 0.7 0.3 0.0 100.4 6.3 125.0 0.3 0.3 26.4 3.8 266.7 409.5 254.8 169.8 0.1 15.8 0.5 284.6 0.5 0.2 0.4 4.1 1.0 76.3 0.2 165.3 0.3 202.3 0.2 0.1 0.1 81.5 0.6 1.8 57.4 0.9 7.2 351.8 317.8 214.6 307.7 540.8 0.5 0.9 1.0 211.5 0.5 241.8 1.5 0.3 0.2 0.1 0.4 0.2 0.1 0.3 0.1 6.0 0.1 0.3 0.3 0.3 11.1 0.2 25.7 0.4 0.3 17.5 22.6 19.7 17.7 16.6 18.8 26.8 20.6 22.1 20.9 24.0 21.9 13.5 9.6 3.6 35.9 1.9 41.7 88.3 10.3 3.4 0.5 2.3 14.2 8.6 1.5 4.4 5.5 0.0 4.2 0.8 0.1 0.0 6.9 8.7 6.0 45.8 17.7 0.0 0.0 0.8 0.2 2.1 147.2 1.5 5.4 0.0 17.3 11.0 1.2 28.8 1.7 1.1 0.1 2.0 187.5 185.5 5.5 61.5 61.4 26.6 30.9 3.1 26.8 0.0 11.1 0.5 14.5 0.1 79.7 0.8 123.4 0.3 0.1 2.8 1.2 210.4 38.1 171.1 1.9 2.0 1.2 29.1 11.5 3.6 2.5 0.1 28.0 B3GALNT1 "B3GALT3, beta3Gal-T3, galT3, GLOB, P1" ENSG00000169255 "Beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group)" O75752 3 161083883-161105411 "Blood group antigen proteins, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Blood group antigen, Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 53.3" "Cell type enhanced" "Detected in many" "Bipolar cells: 56.3;Cardiomyocytes: 56.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 7 "basophil: 8.8;NK-cell: 22.1" "Group enriched" "Detected in many" 7 "granulocytes: 8.8;NK-cells: 22.1" "Cell line enhanced" "Detected in many" "RT4: 128.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041204 Approved Vesicles NA NA 400000 "Cluster 48: NK-cells - Unknown function" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 15: RT4 - Unknown function" "Cluster 56: Bipolar cells - Visual perception" Vesicles "HPA041204: AB_10795585" "unprognostic (3.85e-2)" "unprognostic (5.11e-3)" "unprognostic (3.02e-1)" "unprognostic (1.06e-2)" "unprognostic (7.83e-2)" "unprognostic (4.07e-2)" "unprognostic (9.26e-5)" "unprognostic (1.49e-2)" "unprognostic (1.12e-2)" "unprognostic (1.88e-2)" "unprognostic (3.44e-2)" "unprognostic (3.24e-1)" "unprognostic (2.09e-3)" "unprognostic (1.32e-1)" "unprognostic (4.90e-2)" "unprognostic (3.66e-2)" "unprognostic (3.19e-3)" 5.3 7.2 20.7 3.9 21.5 4.8 9.8 14.7 19.6 20.1 8.0 2.7 1.9 9.9 8.5 6.8 14.2 9.9 53.3 21.7 26.7 19.4 1.2 14.6 4.9 12.8 21.7 18.8 11.1 8.6 9.8 13.9 18.0 11.6 2.4 26.6 22.3 8.5 1.4 2.5 2.4 9.9 14.1 6.2 10.7 8.4 25.7 2.8 27.0 3.2 5.4 12.3 5.4 13.0 17.3 0.3 7.5 0.1 1.0 2.8 0.1 9.3 8.7 22.3 7.3 11.3 13.2 0.0 35.7 8.0 12.7 3.9 0.0 16.9 7.5 0.0 0.0 9.0 5.7 0.0 11.2 0.2 0.0 23.3 5.4 6.1 1.4 15.6 31.6 0.0 0.0 0.0 8.3 29.4 0.1 0.0 17.4 0.2 38.9 0.1 0.0 0.2 9.3 128.3 15.1 0.1 23.7 8.8 6.3 3.0 35.6 13.3 0.0 0.2 15.5 0.5 0.2 3.6 0.1 0.2 14.7 0.0 0.0 8.8 0.2 0.0 0.4 0.2 0.4 2.3 0.2 0.4 1.7 0.2 0.4 0.9 0.4 22.1 0.1 1.1 0.0 0.7 20.7 21.5 14.7 19.6 21.7 26.7 12.8 21.7 18.0 14.1 25.7 13.0 5.0 19.2 2.2 10.1 2.1 5.0 5.2 5.7 6.2 56.3 7.5 6.2 56.9 0.0 8.0 14.7 12.5 21.2 1.2 0.1 11.7 3.5 0.7 4.9 5.8 7.7 1.8 17.0 22.3 8.5 13.0 13.3 4.6 8.7 10.2 13.0 6.1 0.2 9.8 6.7 27.5 0.1 6.1 2.1 6.8 2.2 7.2 3.4 10.6 9.4 4.3 12.6 1.0 14.6 3.2 9.8 0.1 5.3 0.2 6.2 0.1 15.8 3.1 8.4 0.0 5.3 13.2 6.5 20.7 8.4 2.6 5.1 1.2 4.6 0.7 4.5 B3GALNT2 MGC39558 ENSG00000162885 "Beta-1,3-N-acetylgalactosaminyltransferase 2" Q8NCR0 1 235447190-235504452 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Congenital muscular dystrophy, Disease variant, Dystroglycanopathy, Lissencephaly" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in many" 4 "Cone photoreceptor cells: 252.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007846, HPA050662" Approved Uncertain "Golgi apparatus" "Intracellular and membrane" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 59: Non-specific - Translation" "Cluster 20: HeLa - Mitochondria" "Cluster 9: Photoreceptor cells - Phototransduction" "Golgi apparatus" "HPA007846: , HPA050662: AB_2681209" "unprognostic (5.50e-2)" "unprognostic (3.16e-3)" "unprognostic (6.60e-2)" "unprognostic (1.63e-1)" "unprognostic (1.36e-2)" "unprognostic (1.28e-1)" "unprognostic (7.59e-3)" "unprognostic (1.96e-2)" "unprognostic (3.39e-2)" "unprognostic (3.38e-1)" "unprognostic (7.19e-3)" "unprognostic (2.89e-1)" "unprognostic (1.99e-1)" "unprognostic (5.52e-2)" "unprognostic (3.40e-1)" "unprognostic (3.53e-3)" "unprognostic (8.34e-3)" 4.7 5.4 2.3 2.8 2.2 1.6 4.0 2.5 2.4 5.3 5.7 8.1 3.2 7.3 4.8 8.9 5.5 5.3 6.1 2.4 2.6 3.3 3.2 3.4 2.2 2.4 2.7 5.1 22.3 6.7 3.8 4.3 2.3 7.3 5.3 3.9 6.0 6.6 23.3 6.2 5.1 10.6 2.3 2.7 8.9 5.9 2.5 3.6 7.3 16.7 3.4 7.9 5.4 2.2 15.0 10.4 11.1 16.2 14.2 15.7 21.6 14.1 11.8 9.8 10.0 7.7 13.1 8.2 15.3 15.5 7.0 17.3 21.3 14.8 12.5 14.5 11.7 5.8 12.7 9.3 10.0 17.9 4.3 9.9 9.5 10.4 21.5 7.0 14.1 19.2 10.9 10.9 9.2 7.3 10.0 8.8 15.7 7.9 3.1 10.6 19.9 18.8 6.4 21.1 14.2 16.8 23.7 7.8 12.2 3.9 18.5 15.6 13.1 9.7 13.3 16.6 18.1 11.3 14.8 5.0 6.7 12.1 21.7 1.1 1.1 0.5 0.6 1.6 0.8 0.6 0.6 0.7 2.3 0.5 0.5 0.9 0.2 1.2 1.4 1.9 0.3 0.4 2.3 2.2 2.5 2.4 2.4 2.6 2.4 2.7 2.3 2.3 2.5 2.2 9.6 9.6 5.0 38.8 7.8 31.2 39.0 15.1 36.5 33.1 8.9 6.7 6.7 1.5 9.5 5.5 252.3 20.3 14.6 5.2 0.0 6.9 26.7 20.2 14.8 7.0 9.0 5.0 38.4 7.2 7.0 11.5 10.7 19.9 5.7 11.9 4.6 4.7 3.9 28.6 56.2 6.2 4.1 3.0 16.3 7.3 10.5 6.9 1.8 23.4 11.5 11.2 7.2 29.1 21.7 9.2 5.4 16.1 14.0 27.6 9.7 2.3 8.1 18.4 0.0 21.0 20.5 35.8 40.3 28.5 29.7 22.4 9.0 17.6 7.0 33.1 B3GALT1 beta3Gal-T1 ENSG00000172318 "Beta-1,3-galactosyltransferase 1" Q9Y5Z6 2 167868948-167874041 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 5.8;skeletal muscle: 5.2;tongue: 17.8" "Group enriched" "Detected in some" 6 "Astrocytes: 920.7;Excitatory neurons: 519.3;Inhibitory neurons: 723.8" "Cancer enhanced" "Detected in some" "glioma: 2.2" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 8 "AN3-CA: 35.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 11: Basophils - Unknown function" "Cluster 47: Non-specific - Unknown function" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "unprognostic (1.98e-2)" "unprognostic (4.34e-2)" "unprognostic (1.12e-2)" "unprognostic (7.22e-2)" "unprognostic (1.67e-1)" "unprognostic (4.23e-3)" "unprognostic (2.49e-1)" "unprognostic (2.84e-2)" "unprognostic (1.30e-1)" "unprognostic (3.94e-2)" "unprognostic (8.72e-2)" "unprognostic (6.44e-2)" "unprognostic (2.30e-3)" "unprognostic (8.34e-2)" "unprognostic (1.98e-2)" "unprognostic (1.44e-1)" "unprognostic (3.79e-1)" 0.2 0.5 4.0 0.2 5.4 0.1 0.4 2.0 5.8 0.3 0.0 3.6 0.0 0.2 0.4 0.1 0.6 0.0 0.0 5.8 3.0 0.1 0.0 0.1 0.0 2.4 2.9 0.2 0.3 0.0 1.8 0.0 1.4 0.2 3.6 2.4 0.2 0.7 5.2 0.2 0.2 0.2 2.0 0.2 0.0 0.5 2.6 0.0 0.2 17.8 0.0 0.0 0.2 3.4 0.0 0.0 2.8 35.7 0.3 0.0 0.0 0.5 0.1 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.1 0.1 0.0 1.4 0.1 0.0 0.0 0.0 0.0 4.6 0.0 1.2 0.0 0.2 0.0 0.5 0.0 2.3 0.4 0.0 0.0 0.7 1.6 0.0 0.0 0.0 0.2 0.1 0.3 0.4 0.0 0.8 0.0 0.7 0.0 3.3 0.5 0.0 0.0 0.1 0.0 0.1 0.2 0.1 0.1 0.0 0.2 0.3 0.2 0.2 0.1 0.0 0.1 0.1 0.0 4.0 5.4 2.0 5.8 5.8 3.0 2.4 2.9 1.4 2.0 2.6 3.4 0.2 0.0 1.3 920.7 0.2 0.1 0.0 0.0 0.0 3.0 0.1 2.4 0.8 0.0 0.0 0.0 0.0 0.0 0.1 18.3 0.0 0.1 0.5 0.1 0.6 0.7 0.0 0.0 519.3 0.2 0.0 0.5 0.0 0.4 1.3 0.0 0.0 0.0 0.1 1.7 723.8 3.8 0.0 0.0 0.3 0.0 0.6 0.3 1.8 39.4 0.0 2.4 0.0 108.0 30.3 0.0 3.4 1.5 0.0 0.4 0.0 0.4 0.0 1.3 0.0 1.1 0.6 0.0 1.7 0.0 0.0 0.0 0.1 0.1 7.4 0.1 B3GALT2 beta3Gal-T2 ENSG00000162630 "Beta-1,3-galactosyltransferase 2" O43825 1 193178730-193186613 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 17.2;gallbladder: 15.0;heart muscle: 21.0" "Cell type enhanced" "Detected in some" "Bipolar cells: 46.6;Cardiomyocytes: 34.4;Excitatory neurons: 27.6;Inhibitory neurons: 28.3;Leydig cells: 31.7;Peritubular cells: 21.1" "Cancer enhanced" "Detected in some" "glioma: 2.4" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 4 "MAIT T-cell: 8.4" "Lineage enriched" "Detected in single" 53 "T-cells: 8.4" "Group enriched" "Detected in some" 4 "AF22: 18.3;ASC TERT1: 8.1;LHCN-M2: 12.6;WM-115: 21.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA078659 Approved "Plasma membrane" NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 17: WM-115 - Nervous system development" "Cluster 56: Bipolar cells - Visual perception" "Plasma membrane" "HPA078659: AB_2686887" "unprognostic (1.83e-2)" "unprognostic (3.81e-2)" "unprognostic (1.91e-2)" "unprognostic (1.17e-1)" "unprognostic (3.67e-1)" "unprognostic (1.58e-3)" "unprognostic (2.34e-3)" "unprognostic (2.43e-3)" "unprognostic (1.63e-1)" "unprognostic (2.44e-1)" "unprognostic (6.14e-4)" "unprognostic (4.41e-2)" "unprognostic (8.10e-3)" "unprognostic (2.72e-1)" "unprognostic (1.36e-1)" "unprognostic (1.89e-1)" "unprognostic (4.56e-3)" 0.3 1.2 13.4 0.7 15.3 0.2 0.3 4.9 17.1 0.2 2.3 1.0 0.9 0.1 1.0 0.6 0.2 15.0 21.0 17.2 7.1 0.9 0.2 1.8 0.2 5.8 7.4 10.4 0.2 0.0 0.5 0.3 5.8 4.7 1.2 6.6 0.1 5.1 0.1 0.2 3.0 0.1 7.0 0.8 1.3 0.7 8.5 0.0 1.0 0.3 0.9 1.4 0.3 15.9 0.0 0.0 18.3 0.0 0.5 8.1 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 3.6 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 12.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 1.6 1.1 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 21.9 0.0 0.0 0.0 0.2 0.0 8.4 0.0 1.9 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.8 0.2 13.4 15.3 4.9 17.1 17.2 7.1 5.8 7.4 5.8 7.0 8.5 15.9 0.6 0.0 0.5 1.6 0.9 0.3 0.1 0.0 0.6 46.6 0.0 0.1 34.4 11.5 0.0 1.8 4.2 0.0 0.2 0.1 0.0 0.1 0.0 0.3 1.3 1.1 3.0 0.8 27.6 0.0 0.0 2.0 0.0 0.9 2.5 0.4 0.7 0.1 0.3 8.4 28.3 0.7 0.0 0.6 0.3 0.7 31.7 0.7 0.0 4.7 0.0 2.4 0.0 12.1 9.3 0.5 0.1 21.1 0.4 0.1 3.4 0.1 2.2 6.2 0.0 0.3 1.2 0.0 0.0 0.3 0.3 0.0 4.9 0.3 0.5 0.0 B3GALT4 "beta3Gal-T4, GalT4" ENSG00000235863 "Beta-1,3-galactosyltransferase 4" O96024 6 33277123-33284832 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 27.9" "Cell type enhanced" "Detected in many" "Late spermatids: 71.8;Spermatocytes: 81.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in some" "HDLM-2: 4.0;MOLT-4: 1.1;SCLC-21H: 2.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA043001 Approved NA NA "Cluster 24: B-cells - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 44: HDLM-2 - Immune response" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA043001: AB_2678265" "unprognostic (3.71e-2)" "unprognostic (1.33e-2)" "unprognostic (6.02e-2)" "unprognostic (1.00e-1)" "unprognostic (6.10e-3)" "unprognostic (1.66e-2)" "unprognostic (6.00e-2)" "unprognostic (2.17e-1)" "unprognostic (1.39e-1)" "unprognostic (1.84e-1)" "unprognostic (1.98e-2)" "unprognostic (1.96e-1)" "unprognostic (1.17e-3)" "unprognostic (6.83e-2)" "unprognostic (1.94e-1)" "unprognostic (1.22e-2)" "unprognostic (3.75e-2)" 9.3 8.8 0.4 0.0 0.8 0.0 8.0 1.8 1.2 8.5 0.5 11.7 0.0 8.1 0.0 19.5 6.5 0.0 8.5 0.2 0.4 7.0 1.5 7.6 0.0 1.5 0.9 3.5 3.4 0.0 5.6 0.0 1.2 9.0 0.0 0.0 12.4 0.0 2.5 15.2 10.8 0.0 0.8 12.8 9.5 27.9 0.8 0.0 7.3 0.0 0.0 9.7 11.2 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 7.7 4.6 2.4 1.8 1.8 1.8 3.1 2.5 8.8 1.8 2.4 2.8 5.0 5.7 4.7 4.5 2.0 0.4 0.8 1.8 1.2 0.2 0.4 1.5 0.9 1.2 0.8 0.8 1.3 12.6 12.8 4.8 1.3 12.0 3.2 6.3 18.9 4.0 14.5 7.6 4.2 3.8 15.7 18.9 14.7 4.2 18.4 20.2 38.2 5.9 17.7 36.8 12.1 3.1 11.1 12.6 5.2 1.0 18.4 12.9 8.2 13.3 11.0 10.2 5.0 15.0 0.4 20.3 11.8 1.4 15.8 16.2 22.3 8.6 71.8 7.8 15.2 8.8 4.7 27.2 9.8 54.6 1.5 2.1 20.0 32.6 6.0 6.2 9.1 35.5 6.1 26.0 15.0 6.6 3.3 5.9 81.2 2.7 13.2 4.8 32.0 14.2 5.1 11.2 17.0 B3GALT6 beta3GalT6 ENSG00000176022 "Beta-1,3-galactosyltransferase 6" Q96L58 1 1232237-1235041 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Disease variant, Dwarfism, Ehlers-Danlos syndrome" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "SCLC-21H: 69.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA 14000 "Cluster 27: Non-specific - Gene expression" "Cluster 35: Non-specific - Unknown function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 52: Non-specific - Transcription" "unprognostic (9.76e-2)" "unprognostic (6.97e-2)" "unprognostic (4.70e-2)" "unprognostic (1.44e-1)" "unprognostic (1.39e-1)" "unprognostic (4.62e-2)" "unprognostic (2.65e-3)" "unprognostic (1.86e-1)" "unprognostic (1.37e-1)" "unprognostic (2.66e-1)" "unprognostic (3.08e-2)" "unprognostic (2.40e-2)" "unprognostic (1.85e-1)" "unprognostic (1.54e-1)" "unprognostic (1.48e-1)" "unprognostic (3.28e-1)" "unprognostic (9.89e-2)" 8.7 8.7 8.9 5.6 9.0 1.8 8.4 7.3 9.9 7.6 7.3 6.5 3.9 10.7 3.8 7.2 7.7 3.7 10.1 9.5 10.1 9.9 13.5 6.8 6.2 10.4 9.3 7.0 11.9 7.8 9.3 5.2 8.8 8.0 3.0 2.4 6.4 4.2 9.3 9.2 6.5 4.8 8.3 10.3 7.8 5.4 9.0 5.8 7.7 4.8 3.7 7.6 6.3 9.3 20.4 10.2 17.0 17.9 16.8 11.3 13.2 21.2 17.9 17.4 14.1 9.1 20.3 15.1 12.4 12.7 15.2 17.9 7.4 11.4 10.6 26.8 28.2 28.2 10.1 8.7 17.3 17.6 17.1 10.6 8.3 11.6 11.3 10.5 13.3 17.2 20.0 13.2 18.0 11.6 24.0 31.6 21.9 21.2 37.9 22.8 6.7 12.5 17.4 6.1 69.6 28.6 15.8 18.4 11.4 9.9 15.4 24.9 14.4 17.9 7.9 11.3 30.9 8.2 7.6 14.0 14.1 38.9 20.8 1.3 1.2 0.4 1.6 1.6 2.8 1.4 1.6 1.9 1.7 2.3 1.4 1.7 0.6 2.9 2.0 2.3 0.7 1.0 8.9 9.0 7.3 9.9 9.5 10.1 10.4 9.3 8.8 8.3 9.0 9.3 15.6 12.8 9.9 3.9 13.7 8.4 31.1 3.8 2.2 13.1 15.4 17.5 8.4 11.5 3.4 12.9 4.2 1.7 20.9 3.8 7.9 8.1 0.6 7.6 16.0 12.5 6.0 5.9 3.8 12.7 3.4 10.8 5.1 9.4 0.0 24.7 11.4 13.6 7.3 20.2 5.0 3.7 4.1 12.2 10.3 2.2 2.8 10.5 1.8 1.9 6.9 11.0 18.6 5.5 3.8 11.9 1.0 4.1 9.6 24.5 1.6 10.9 3.0 9.4 0.0 13.6 10.8 1.7 4.1 3.7 12.6 1.4 11.1 33.2 5.3 14.8 B3GAT1 "CD57, GlcAT-P, HNK-1, LEU7, NK-1" ENSG00000109956 "Beta-1,3-glucuronyltransferase 1" Q9P2W7 11 134378504-134412242 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "brain: 195.2" "Cell type enhanced" "Detected in some" "Astrocytes: 27.4;Bipolar cells: 37.0;Excitatory neurons: 37.2;Inhibitory neurons: 30.4;Muller glia cells: 116.2;Oligodendrocyte precursor cells: 33.2;Oligodendrocytes: 77.8" "Group enriched" "Detected in some" 11 "glioma: 10.8;prostate cancer: 3.5;thyroid cancer: 4.1" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "gdT-cell: 1.1" "Lineage enriched" "Detected in single" 12 "T-cells: 1.1" "Cell line enhanced" "Detected in some" "AF22: 23.1;HMC-1: 25.3;NTERA-2: 22.1;SH-SY5Y: 8.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002500, CAB010893, HPA069468, HPA074314" Enhanced Enhanced Vesicles "Secreted in brain" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 65: Brain - Ion transport" "Cluster 12: NES - Nervous system development" "Cluster 5: Muller glia cells - Visual perception" Vesicles "CAB002500: AB_563601, CAB010893: AB_1078474, HPA069468: AB_2686138, HPA074314: " "unprognostic (6.72e-2)" "unprognostic (3.97e-4)" "unprognostic (2.13e-2)" "unprognostic (1.40e-3)" "unprognostic (5.52e-2)" "unprognostic (2.60e-3)" "unprognostic (6.30e-2)" "unprognostic (1.96e-2)" "unprognostic (8.74e-2)" "unprognostic (2.72e-1)" "unprognostic (1.57e-3)" "unprognostic (1.58e-1)" "unprognostic (9.34e-3)" "unprognostic (3.87e-3)" "unprognostic (2.42e-1)" "unprognostic (4.07e-2)" "unprognostic (2.26e-2)" 0.2 4.2 146.6 0.4 135.6 1.0 3.9 114.3 195.2 0.4 32.5 0.9 0.5 1.4 0.2 0.2 0.4 0.3 0.3 191.8 85.5 1.8 5.8 0.6 2.1 133.6 145.2 0.2 0.4 0.0 4.5 0.1 118.9 2.8 0.1 23.8 1.2 0.4 0.1 0.5 0.6 0.1 115.0 1.4 34.9 0.9 133.6 0.4 6.2 0.2 0.4 0.7 0.3 176.0 0.0 0.0 23.1 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.7 3.9 0.0 0.9 1.2 1.6 0.0 0.0 0.0 0.7 0.1 0.2 0.0 0.1 0.1 25.3 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.3 0.0 0.1 0.0 0.1 22.1 1.1 0.0 0.4 0.0 1.7 0.0 0.1 3.1 8.4 0.0 0.0 0.0 1.5 0.1 0.0 0.1 0.0 2.3 0.1 0.0 0.1 0.0 0.1 0.2 0.1 5.8 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.2 0.6 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.1 146.6 135.6 114.3 195.2 191.8 85.5 133.6 145.2 118.9 115.0 133.6 176.0 0.1 0.0 0.0 27.4 0.1 0.0 0.0 0.0 0.0 37.0 1.2 0.8 1.1 2.8 0.0 0.0 4.2 0.0 14.4 0.1 0.0 0.0 1.8 0.1 0.1 0.4 1.8 0.4 37.2 0.0 0.0 0.1 0.0 0.2 0.0 0.1 0.4 4.7 0.1 23.5 30.4 0.0 0.0 0.3 0.0 3.9 0.0 0.2 0.0 3.7 0.0 116.2 15.5 33.2 77.8 0.0 0.0 0.4 7.5 0.9 0.0 1.9 0.0 8.6 0.0 0.1 0.2 0.2 0.8 0.0 0.0 0.1 3.8 0.0 0.0 0.3 B3GAT2 GlcAT-S ENSG00000112309 "Beta-1,3-glucuronyltransferase 2" Q9NPZ5 6 70856679-70957060 "Enzymes, Metabolic proteins, Predicted membrane proteins" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 29.8;retina: 18.4" "Cell type enriched" "Detected in many" 8 "Horizontal cells: 319.7" "Group enriched" "Detected in some" 20 "glioma: 4.7;testis cancer: 1.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 19 "SCLC-21H: 21.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA012059 Uncertain NA NA "Cluster 77: Retina - Visual perception" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 62: Horizontal cells - Visual perception" "HPA012059: AB_2061050" "unprognostic (7.10e-3)" "unprognostic (7.81e-2)" "unprognostic (1.63e-1)" "unprognostic (1.10e-3)" "unprognostic (2.21e-1)" "unprognostic (1.22e-2)" "unprognostic (1.96e-2)" "unprognostic (4.88e-2)" "unprognostic (4.22e-2)" "unprognostic (9.16e-4)" "unprognostic (8.09e-2)" "unprognostic (7.43e-3)" "unprognostic (6.88e-7)" "unprognostic (2.72e-2)" "unprognostic (3.35e-2)" "unprognostic (2.53e-2)" "unprognostic (3.45e-3)" 1.4 0.4 13.9 0.5 20.9 0.4 1.1 12.5 14.5 1.4 6.9 0.9 0.6 0.7 0.1 1.0 0.7 0.2 1.0 25.9 16.2 0.6 0.9 1.0 0.5 20.9 19.1 0.8 1.4 0.0 0.8 0.1 23.7 0.9 0.0 18.4 1.2 0.0 0.8 1.5 1.0 0.1 23.8 0.7 1.1 0.9 16.9 0.5 1.0 0.0 0.0 1.1 1.4 29.8 0.3 0.0 0.6 0.3 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.1 0.2 0.1 0.0 0.1 0.2 0.1 0.0 0.0 0.2 1.1 0.1 0.3 0.2 0.0 0.1 0.4 0.0 0.0 0.0 0.0 0.2 0.0 0.6 0.1 0.5 0.0 0.2 0.0 0.5 0.7 0.1 0.1 0.1 0.2 0.2 0.0 0.2 21.8 0.2 0.0 0.1 0.0 0.3 0.1 0.0 0.1 0.1 0.2 0.1 0.3 0.5 0.0 0.1 0.1 0.1 0.1 0.2 0.1 0.2 0.1 0.1 0.1 0.1 0.2 0.3 0.0 0.1 0.2 0.2 0.3 0.1 0.1 0.1 0.3 0.0 13.9 20.9 12.5 14.5 25.9 16.2 20.9 19.1 23.7 23.8 16.9 29.8 4.5 0.0 2.2 23.8 9.7 25.5 11.9 19.4 0.0 16.5 7.2 1.7 1.0 11.5 9.0 16.5 22.9 6.0 10.0 13.0 0.0 5.6 9.7 3.6 5.4 7.7 0.0 3.2 2.5 3.9 3.9 6.9 2.0 6.0 0.0 2.5 9.3 10.7 7.5 319.7 8.2 4.9 16.2 10.0 27.0 6.0 19.9 5.1 14.2 0.0 11.6 15.2 30.9 32.2 0.2 9.1 15.5 13.5 3.7 16.9 23.3 1.4 3.4 22.5 13.1 5.8 5.8 18.7 36.7 1.2 19.9 7.1 15.1 2.1 6.2 12.2 B3GAT3 GlcAT-I ENSG00000149541 "Beta-1,3-glucuronyltransferase 3" O94766 11 62615296-62622154 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Transferase "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA051328 Approved "Intracellular and membrane" NA NA 990000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 25: RPMI-8226 - Immune response" "Cluster 4: Macrophages - Innate immune response" "HPA051328: AB_2681444" "unprognostic (1.55e-1)" "unprognostic (3.93e-2)" "unprognostic (8.45e-3)" "unprognostic (2.31e-1)" "prognostic unfavorable (4.69e-4)" "unprognostic (3.80e-2)" "prognostic unfavorable (5.11e-6)" "unprognostic (4.94e-2)" "unprognostic (2.42e-1)" "unprognostic (3.66e-2)" "unprognostic (1.08e-3)" "unprognostic (1.40e-1)" "unprognostic (1.58e-3)" "unprognostic (1.46e-3)" "unprognostic (6.00e-2)" "unprognostic (4.48e-2)" "unprognostic (2.58e-2)" 28.2 30.0 63.4 17.0 63.8 18.2 27.4 67.0 81.8 33.7 65.9 27.8 17.2 30.0 11.5 21.0 30.0 15.3 23.1 64.0 66.7 52.1 48.7 29.0 26.2 72.3 64.3 32.3 30.7 19.1 55.7 19.1 76.5 37.1 6.9 16.0 25.9 18.2 14.3 33.9 27.8 14.0 63.3 40.0 28.9 23.9 67.1 18.5 30.1 6.8 10.8 30.5 25.7 69.7 36.0 57.3 32.0 55.0 40.0 38.7 23.4 28.3 38.9 26.7 29.4 25.4 52.3 33.4 91.1 29.5 70.6 24.5 30.8 28.7 6.2 71.5 61.3 17.0 25.9 32.8 96.8 21.4 34.8 69.1 47.6 35.0 15.3 42.4 25.3 37.9 51.5 76.7 33.9 89.1 38.1 76.7 47.5 18.9 55.1 36.7 22.5 175.4 55.0 7.2 33.6 53.1 32.6 38.2 134.6 10.6 52.9 41.6 18.6 28.6 20.8 75.2 54.4 79.3 28.7 37.6 82.3 41.0 56.0 32.0 29.3 27.4 21.6 31.8 14.0 18.5 14.9 17.7 25.8 15.3 14.8 17.2 8.6 41.0 33.8 15.5 19.9 16.4 63.4 63.8 67.0 81.8 64.0 66.7 72.3 64.3 76.5 63.3 67.1 69.7 33.2 6.4 13.2 22.2 36.8 19.8 39.0 53.3 51.2 52.3 33.1 44.4 4.2 31.5 26.1 40.5 33.3 77.0 45.3 26.5 15.6 33.8 0.4 20.0 36.3 22.8 25.2 24.4 19.1 46.3 61.3 34.8 25.5 24.1 1.3 45.3 23.2 28.4 67.8 48.8 25.3 23.9 57.0 35.2 17.5 3.2 36.1 34.4 44.4 8.4 45.3 52.5 49.4 14.6 19.5 36.4 31.2 22.6 51.0 30.6 27.3 16.2 15.2 49.6 26.3 22.3 33.7 6.8 25.8 21.9 19.5 43.5 41.7 31.9 28.3 21.0 B3GNT2 "B3GN-T1, B3GN-T2, B3GNT-2, B3GNT1, BETA3GNT" ENSG00000170340 "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2" Q9NY97 2 62196115-62224731 "Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "REH: 115.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005997 Approved Approved Vesicles NA NA 99000000 "Cluster 5: Granulocytes - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 14: REH - Unknown function" "Cluster 48: Smooth muscle cells - ECM organization" Vesicles "HPA005997: AB_1845234" "unprognostic (1.38e-1)" "unprognostic (1.13e-1)" "unprognostic (1.28e-1)" "unprognostic (2.64e-2)" "unprognostic (1.23e-2)" "unprognostic (1.67e-1)" "unprognostic (1.51e-1)" "unprognostic (1.55e-2)" "unprognostic (2.13e-2)" "unprognostic (3.76e-1)" "prognostic unfavorable (1.62e-4)" "unprognostic (3.63e-1)" "unprognostic (1.11e-2)" "unprognostic (9.55e-2)" "unprognostic (3.05e-2)" "unprognostic (3.18e-1)" "unprognostic (1.25e-1)" 17.3 20.8 6.6 13.3 13.6 72.7 26.1 5.9 9.8 25.9 9.0 19.4 27.7 24.6 6.2 25.1 12.7 27.4 19.0 6.8 8.6 33.4 21.8 34.2 24.1 6.9 8.3 5.9 39.7 7.6 13.2 30.6 9.7 10.8 24.3 5.2 15.5 8.2 3.2 11.0 14.4 24.1 6.1 14.9 18.2 7.6 8.5 25.5 19.5 9.0 18.3 20.1 12.8 6.7 20.7 14.0 20.9 9.3 22.5 10.0 60.0 19.8 21.8 15.4 20.5 29.2 32.5 22.3 17.8 18.5 21.6 19.4 13.3 16.6 26.5 46.8 10.8 55.1 6.4 17.2 16.8 33.2 23.8 12.3 30.7 29.6 10.5 11.0 23.4 15.3 30.4 13.7 18.9 15.7 63.7 49.6 20.0 37.4 5.8 115.0 14.4 12.3 29.2 20.1 20.1 14.9 14.1 29.9 23.5 33.4 8.6 38.7 26.7 18.6 16.4 31.7 19.9 38.2 14.4 96.2 14.6 56.5 18.4 14.9 9.0 56.2 20.0 8.6 28.0 14.8 14.7 34.6 10.6 16.6 17.3 26.0 21.3 41.0 11.7 13.3 26.2 17.6 6.6 13.6 5.9 9.8 6.8 8.6 6.9 8.3 9.7 6.1 8.5 6.7 40.3 64.1 9.8 2.0 31.4 71.5 30.9 20.8 92.2 15.6 40.0 20.7 9.2 18.6 21.9 18.4 0.0 40.9 43.8 42.7 23.5 24.0 0.1 51.1 30.3 31.8 9.5 61.6 11.2 57.2 38.3 19.5 36.7 97.3 3.8 9.7 37.5 21.3 60.4 0.0 3.4 22.7 87.5 20.5 58.5 0.7 2.5 34.4 35.6 14.0 19.7 8.6 18.6 2.5 7.2 36.3 24.8 2.2 25.8 25.5 14.2 19.0 19.1 2.1 65.7 8.1 68.2 0.3 1.6 77.4 64.8 65.3 45.9 10.6 13.9 41.1 B3GNT3 "B3GN-T3, B3GNT-3, beta3Gn-T3, HP10328, TMEM3" ENSG00000179913 "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3" Q9Y2A9 19 17794828-17813576 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 44.0;salivary gland: 31.4;stomach 1: 43.2" "Cell type enhanced" "Detected in many" "Cholangiocytes: 65.8;Cytotrophoblasts: 78.9;Distal enterocytes: 108.4;Paneth cells: 67.4;Proximal enterocytes: 50.5;Syncytiotrophoblasts: 68.3" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A-431: 44.2;BEWO: 40.9;CAPAN-2: 112.5;OE19: 102.1;RT4: 41.3;SK-BR-3: 38.4" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA024298 Enhanced "Intracellular and membrane" NA NA 74000 "Cluster 32: T-cells - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA024298: AB_1845236" "unprognostic (1.10e-1)" "unprognostic (5.19e-2)" "unprognostic (1.84e-1)" "unprognostic (4.84e-3)" "unprognostic (1.10e-1)" "unprognostic (1.18e-1)" "prognostic unfavorable (4.25e-5)" "unprognostic (3.26e-1)" "unprognostic (4.64e-2)" "prognostic unfavorable (2.16e-4)" "unprognostic (1.91e-1)" "unprognostic (1.44e-2)" "unprognostic (7.38e-2)" "unprognostic (1.26e-1)" "unprognostic (7.10e-2)" "unprognostic (2.57e-2)" 0.3 0.1 0.3 5.7 0.1 0.2 3.4 0.7 0.4 4.4 0.3 44.0 32.6 0.4 0.0 21.7 1.0 23.8 0.0 0.3 0.3 3.8 2.4 0.5 0.5 0.3 0.2 0.1 3.9 0.5 0.0 12.6 0.3 2.2 40.5 0.0 31.4 3.2 0.0 2.7 29.5 1.7 0.0 0.1 43.2 0.1 0.1 0.2 0.3 0.0 4.7 18.5 8.1 0.5 44.2 12.5 0.0 0.2 0.0 0.0 40.9 0.0 0.0 0.0 0.0 0.7 112.5 0.0 28.9 0.0 0.1 4.2 0.0 12.9 0.0 0.0 0.2 0.0 0.2 5.6 0.0 0.0 0.1 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 17.7 0.2 0.1 0.4 102.1 19.2 0.2 0.0 1.2 23.9 41.3 0.0 0.1 0.0 38.4 0.0 0.0 1.7 0.2 0.1 0.3 3.3 0.2 0.1 0.0 0.1 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.3 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.1 0.7 0.4 0.3 0.3 0.3 0.2 0.3 0.0 0.1 0.5 0.1 0.0 2.3 0.0 0.2 0.1 3.6 5.1 0.0 0.0 7.1 6.2 0.4 65.8 17.1 16.5 0.0 78.9 0.5 108.4 1.9 17.9 0.0 3.8 0.8 2.3 16.3 0.0 0.1 28.4 7.5 0.7 19.9 7.7 5.7 0.0 0.7 0.2 6.0 0.0 0.2 40.7 6.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.6 0.0 0.0 0.0 0.1 33.2 67.4 0.0 0.0 7.8 50.5 3.5 7.7 0.0 0.0 0.0 0.9 0.2 0.3 0.2 0.0 68.3 0.2 0.5 28.4 39.6 B3GNT4 "B3GN-T4, beta3Gn-T4" ENSG00000176383 "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4" Q9C0J1 12 122203681-122208952 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 4.9;skin 1: 3.1" "Cell type enhanced" "Detected in some" "Basal respiratory cells: 3.3;Excitatory neurons: 3.2;Proximal tubular cells: 9.7;Spermatogonia: 2.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HDLM-2: 5.1;hTCEpi: 4.0;T-47d: 4.2;U-266/84: 3.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA055261 Uncertain Approved Nucleoli,Mitochondria NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 6: Brain - Smell perception" "Cluster 44: HDLM-2 - Immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Mitochondria Nucleoli "HPA055261: AB_2682765" "unprognostic (1.67e-1)" "unprognostic (1.66e-1)" "unprognostic (1.27e-1)" "unprognostic (2.36e-1)" "unprognostic (1.10e-2)" "unprognostic (2.60e-2)" "unprognostic (1.32e-3)" "unprognostic (1.98e-1)" "unprognostic (3.44e-2)" "unprognostic (1.21e-1)" "unprognostic (3.82e-2)" "unprognostic (3.69e-1)" "prognostic unfavorable (3.52e-6)" "unprognostic (1.24e-1)" "unprognostic (2.79e-1)" "unprognostic (8.97e-2)" "unprognostic (9.47e-2)" 0.2 0.7 2.3 0.1 2.6 1.5 0.2 4.9 3.1 0.3 0.0 0.3 0.2 0.1 0.0 1.3 0.6 0.2 0.1 3.8 0.5 2.7 0.4 0.3 0.1 0.0 0.0 0.2 0.3 0.3 1.4 0.1 0.0 0.4 0.0 0.5 0.5 0.0 0.2 3.1 0.3 0.0 0.0 0.5 0.3 1.6 0.9 0.0 0.4 0.0 0.1 0.1 0.5 1.2 3.4 0.6 0.2 1.4 0.1 0.1 0.6 0.1 0.0 0.2 0.3 2.2 0.3 0.3 0.5 0.0 0.2 1.3 1.7 1.2 0.1 5.1 1.9 0.1 1.3 0.2 0.4 0.5 0.7 0.3 4.0 0.1 0.2 0.5 0.0 1.3 1.0 0.4 0.0 3.2 0.0 0.5 0.4 0.1 1.4 0.2 0.4 0.7 0.5 0.4 0.8 1.1 0.9 0.7 0.4 0.5 4.2 0.1 0.1 0.3 1.7 0.4 0.2 0.4 3.6 0.8 0.3 0.5 0.2 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.3 0.1 0.0 0.0 2.3 2.6 4.9 3.1 3.8 0.5 0.0 0.0 0.0 0.0 0.9 1.2 0.4 0.0 1.8 0.7 0.3 1.3 0.7 3.3 0.6 0.2 0.7 0.8 0.5 0.0 1.1 0.0 0.0 0.5 0.5 0.6 1.9 1.0 0.4 0.6 0.3 0.3 0.0 0.0 3.2 0.2 1.1 0.3 0.0 0.8 0.0 0.1 0.4 0.0 0.2 0.0 1.4 0.0 2.0 0.6 0.6 0.1 0.3 0.3 0.0 1.9 0.0 0.2 0.0 0.5 0.6 0.4 1.3 0.0 0.4 0.3 0.1 9.7 1.1 0.2 0.0 0.5 0.2 0.8 2.9 0.8 1.4 0.5 0.4 0.1 0.3 0.4 B3GNT5 "B3GN-T5, beta3Gn-T5" ENSG00000176597 "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5" Q9BYG0 3 183253253-183298504 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Developmental protein, Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 76.5" "Cell type enhanced" "Detected in many" "Adipocytes: 151.2;Distal enterocytes: 150.4;Squamous epithelial cells: 169.9;Syncytiotrophoblasts: 157.9;Urothelial cells: 144.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 6 "neutrophil: 5.6" "Lineage enriched" "Detected in many" 6 "granulocytes: 5.6" "Cell line enhanced" "Detected in many" "GAMG: 82.4;HBEC3-KT: 70.3;hTCEpi: 83.5" "Region enriched" "Detected in many" 4 "cerebellum: 14.7" "Low region specificity" "Detected in all" HPA017292 Uncertain Approved Nucleoli NA NA 28000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 30: Epithelial cell lines - Translation" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoli "HPA017292: AB_1845237" "unprognostic (2.17e-1)" "unprognostic (5.73e-2)" "unprognostic (1.07e-2)" "unprognostic (4.83e-3)" "unprognostic (1.89e-1)" "unprognostic (3.08e-2)" "prognostic unfavorable (5.09e-4)" "unprognostic (7.10e-3)" "unprognostic (7.78e-2)" "unprognostic (8.48e-2)" "prognostic unfavorable (7.23e-6)" "unprognostic (4.20e-1)" "prognostic unfavorable (1.30e-7)" "unprognostic (1.18e-2)" "unprognostic (2.71e-1)" "unprognostic (3.53e-2)" "unprognostic (8.10e-3)" 11.9 2.4 3.3 13.7 3.5 76.5 5.5 2.3 3.2 6.0 0.9 22.6 38.2 5.1 9.1 37.5 9.6 21.3 3.5 3.7 4.0 3.8 3.3 15.0 1.1 5.6 3.8 4.6 7.5 3.5 5.7 13.9 4.6 7.9 19.6 1.2 10.1 3.3 7.4 10.3 42.0 6.7 4.3 1.6 11.3 7.3 3.5 7.6 5.2 4.5 5.3 24.2 13.8 5.5 46.2 4.4 23.8 14.7 19.5 57.0 21.5 0.7 1.1 4.6 3.8 9.0 23.6 0.0 2.7 0.1 82.4 20.6 24.7 70.3 3.9 0.1 15.3 2.4 1.9 0.0 24.8 23.4 10.9 27.0 83.5 3.7 62.1 6.2 43.4 0.1 26.6 0.1 38.1 0.0 0.1 7.6 10.1 26.9 38.5 7.3 12.0 0.1 14.4 12.7 1.0 22.6 12.7 0.1 5.3 10.6 0.0 28.0 64.6 1.1 9.0 1.4 11.0 0.0 0.0 0.0 8.8 54.1 23.8 0.0 1.0 1.0 0.0 0.1 0.0 0.0 0.1 0.0 0.7 0.0 0.0 0.0 5.6 0.0 0.0 0.0 0.2 0.3 3.3 3.5 2.3 3.2 3.7 4.0 5.6 3.8 4.6 4.3 3.5 5.5 151.2 6.4 17.5 2.3 1.2 65.1 70.2 35.8 101.3 10.0 18.4 10.4 2.2 21.5 40.5 5.5 22.9 31.0 1.9 150.4 1.9 18.0 13.4 58.0 13.1 26.3 38.2 6.3 1.8 11.8 10.7 9.2 70.3 55.3 14.0 2.4 2.2 0.6 29.6 3.3 1.5 88.2 34.6 15.6 123.2 26.5 1.5 76.8 12.4 80.6 9.4 3.1 0.0 4.5 0.8 35.7 126.4 0.4 1.4 43.1 74.9 4.8 118.5 13.1 0.0 23.6 5.4 7.9 0.8 169.9 84.8 157.9 4.3 0.2 36.2 144.4 B3GNT6 B3Gn-T6 ENSG00000198488 "UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 6" Q6ZMB0 11 77034398-77041973 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "intestine: 21.8;salivary gland: 6.4;stomach 1: 24.9" "Group enriched" "Detected in some" 20 "Gastric mucus-secreting cells: 23.0;Intestinal goblet cells: 60.8" "Group enriched" "Detected in some" 14 "colorectal cancer: 6.3;lung cancer: 3.9;pancreatic cancer: 5.1;prostate cancer: 5.0;stomach cancer: 4.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA039805 Enhanced "Intracellular and membrane" NA NA "Cluster 11: Basophils - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 27: Mucus-secreting cells - Mucin production" "HPA039805: AB_2676690" "unprognostic (1.71e-1)" "prognostic favorable (2.31e-4)" "unprognostic (4.79e-2)" "unprognostic (5.42e-2)" "unprognostic (7.64e-2)" "unprognostic (1.95e-1)" "unprognostic (2.72e-1)" "unprognostic (1.23e-2)" "unprognostic (7.77e-2)" "unprognostic (2.19e-1)" "unprognostic (9.30e-2)" "unprognostic (1.71e-1)" 0.1 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 21.8 5.4 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.3 16.8 0.0 6.4 0.0 0.0 0.0 7.0 0.3 0.0 0.0 24.9 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.1 0.1 0.1 0.0 0.0 0.2 0.1 0.0 0.5 0.0 0.1 0.0 0.6 0.2 0.0 0.0 0.1 0.1 0.4 0.0 1.0 0.0 0.0 0.0 1.4 2.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.1 0.0 0.0 0.2 23.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.1 60.8 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.7 1.6 1.4 0.0 0.0 0.3 1.2 0.1 0.2 0.0 0.0 0.7 0.2 0.0 0.1 0.0 0.0 0.0 0.2 0.0 1.5 0.2 B4GALNT1 "beta1-4GalNAc-T, GALGT, SPG26" ENSG00000135454 "Beta-1,4-N-acetyl-galactosaminyltransferase 1" Q00973 12 57623409-57633239 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Lipid metabolism, Sphingolipid metabolism" "Glycosyltransferase, Transferase" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "brain: 61.1" "Cell type enhanced" "Detected in some" "Bipolar cells: 10.0;Excitatory neurons: 22.0;Horizontal cells: 21.9;Inhibitory neurons: 13.4;Smooth muscle cells: 7.5" "Cancer enriched" "Detected in many" 6 "glioma: 10.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HDLM-2: 67.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008968 Enhanced "Intracellular and membrane" NA NA 35000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 10: Brain - Neuronal signaling" "Cluster 9: U-2 OS - Unknown function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA008968: AB_1078253" "unprognostic (3.18e-1)" "unprognostic (8.34e-2)" "unprognostic (2.05e-2)" "unprognostic (3.33e-3)" "unprognostic (2.54e-1)" "unprognostic (2.70e-3)" "unprognostic (3.73e-5)" "unprognostic (1.26e-2)" "unprognostic (1.72e-1)" "unprognostic (2.66e-1)" "unprognostic (2.00e-1)" "unprognostic (1.67e-1)" "prognostic unfavorable (3.18e-14)" "unprognostic (2.52e-2)" "unprognostic (1.81e-1)" "unprognostic (1.44e-2)" "unprognostic (4.92e-4)" 1.9 1.1 26.9 1.9 29.7 0.0 0.7 29.3 61.1 1.3 0.6 2.7 0.5 2.1 2.7 0.7 0.7 1.1 3.3 34.9 21.9 0.8 0.4 0.6 0.6 16.7 11.8 0.3 0.3 0.3 1.7 0.4 20.5 2.6 1.2 4.2 1.8 5.0 9.5 0.6 1.2 2.5 8.1 0.6 0.9 0.7 19.1 0.3 1.2 7.2 1.0 1.2 1.6 29.9 7.5 38.2 18.2 38.7 0.3 0.1 0.4 3.0 11.3 19.0 17.5 2.8 21.9 3.0 47.9 13.2 35.9 3.3 15.3 2.1 5.2 67.4 2.6 1.8 10.1 9.9 0.4 3.1 4.1 0.1 0.9 11.0 0.5 6.7 0.2 11.4 8.7 34.8 2.4 13.5 2.5 0.1 13.0 0.9 7.7 0.1 27.1 8.0 0.1 0.1 34.9 12.3 3.1 1.1 0.4 0.9 7.0 3.3 0.0 22.8 28.1 24.0 26.1 37.0 34.0 2.6 28.9 2.3 45.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 26.9 29.7 29.3 61.1 34.9 21.9 16.7 11.8 20.5 8.1 19.1 29.9 0.8 0.0 0.0 2.6 0.0 0.4 0.0 0.0 0.0 10.0 0.0 0.5 4.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.4 0.2 1.0 0.8 0.0 0.0 22.0 0.2 0.2 1.0 0.0 0.0 0.0 0.0 0.4 0.1 0.1 21.9 13.4 0.0 0.0 0.0 0.3 0.7 2.8 0.1 3.6 2.8 2.6 0.7 0.0 4.5 2.7 0.5 0.0 3.0 0.0 0.1 0.0 0.2 0.0 2.6 6.6 0.6 7.5 1.6 4.0 0.0 0.0 0.0 0.4 0.2 0.0 0.1 B4GALNT3 "B4GalNac-T3, FLJ16224, FLJ40362" ENSG00000139044 "Beta-1,4-N-acetyl-galactosaminyltransferase 3" Q6L9W6 12 459939-563509 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "stomach 1: 61.0" "Cell type enhanced" "Detected in many" "Distal enterocytes: 81.1;Gastric mucus-secreting cells: 128.0;Glandular and luminal cells: 47.4;Late spermatids: 89.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 33.5;HDLM-2: 13.2;HEK 293: 12.5;NTERA-2: 14.8" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA011404 Enhanced Supported "Golgi apparatus,Vesicles" "Intracellular and membrane" NA NA "Cluster 24: Salivary gland - Salivary secretion" "Cluster 28: BEWO - Transcription regulation" "Cluster 25: Spermatids - Spermatogenesis" "Golgi apparatus" Vesicles "HPA011404: AB_1845242" "unprognostic (2.38e-2)" "unprognostic (9.59e-3)" "unprognostic (1.38e-1)" "prognostic favorable (1.69e-10)" "unprognostic (4.22e-2)" "unprognostic (4.63e-2)" "unprognostic (1.46e-2)" "unprognostic (9.53e-3)" "unprognostic (3.29e-1)" "unprognostic (1.61e-1)" "unprognostic (1.23e-1)" "unprognostic (1.02e-1)" "unprognostic (5.46e-2)" "unprognostic (9.99e-3)" "unprognostic (2.82e-1)" "unprognostic (2.48e-2)" "unprognostic (2.98e-1)" 0.2 7.0 0.5 3.2 0.7 2.1 1.3 0.0 1.0 7.4 1.0 18.4 1.0 6.2 2.7 7.5 3.7 2.2 23.9 0.5 0.0 4.6 0.1 5.2 0.1 0.0 0.0 0.4 2.6 16.9 9.3 0.1 0.0 2.0 12.5 0.1 4.8 0.7 1.5 14.8 2.0 2.2 0.0 0.3 61.0 8.0 0.0 2.3 2.3 0.1 0.7 1.4 5.6 0.7 0.0 0.0 0.3 1.2 0.0 0.0 33.5 0.0 0.0 0.0 0.0 8.0 6.6 0.0 0.9 0.0 0.7 3.6 8.0 1.1 0.1 13.2 12.5 0.0 0.0 1.8 0.0 0.1 5.3 0.0 5.3 0.0 0.0 0.1 0.0 0.9 0.1 0.0 0.0 0.4 0.0 0.1 14.8 10.5 0.6 0.5 5.0 0.0 7.1 6.8 3.8 2.7 0.8 0.3 1.0 4.9 0.8 2.9 0.0 0.0 2.7 0.2 0.9 0.0 0.0 0.0 0.0 9.2 6.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.7 0.0 1.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 7.0 1.3 0.3 7.5 6.0 3.4 0.0 0.6 2.9 0.6 15.1 1.5 6.2 9.2 0.0 0.0 0.6 81.1 0.0 12.0 26.3 20.4 4.8 0.6 10.3 0.0 32.6 4.8 0.1 1.6 128.0 47.4 0.0 0.1 0.0 0.1 0.7 0.0 5.2 18.6 2.0 0.0 1.1 89.2 0.0 0.5 0.0 2.8 0.6 0.0 0.0 1.0 3.6 16.6 33.4 0.0 0.2 12.7 1.9 0.2 9.1 0.2 0.0 0.2 0.8 2.8 1.3 0.9 17.3 0.0 1.5 1.9 26.1 14.4 B4GALNT4 "FLJ25045, NGalNAc-T1" ENSG00000182272 "Beta-1,4-N-acetyl-galactosaminyltransferase 4" Q76KP1 11 369499-382117 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 33.3;ovary: 27.8" "Cell type enhanced" "Detected in many" "Astrocytes: 133.2;Bipolar cells: 23.8;Excitatory neurons: 31.2;Horizontal cells: 33.7;Inhibitory neurons: 32.3;Muller glia cells: 45.6;Oligodendrocyte precursor cells: 28.1;Oligodendrocytes: 32.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 35.4;NTERA-2: 32.0;SCLC-21H: 39.5;SH-SY5Y: 47.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA043276, HPA053126" Uncertain Uncertain Nucleoplasm,Vesicles,Cytosol "Intracellular and membrane" NA No "Cluster 35: Non-specific - Unknown function" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 64: Astrocytes - Nervous system maintenance" "Nucleoplasm, Cytosol" Vesicles "HPA043276: , HPA053126: AB_2682049" "unprognostic (6.11e-2)" "unprognostic (7.82e-2)" "unprognostic (1.79e-1)" "unprognostic (6.92e-3)" "unprognostic (5.36e-2)" "unprognostic (1.57e-1)" "unprognostic (1.45e-1)" "unprognostic (2.72e-2)" "unprognostic (1.33e-1)" "unprognostic (1.53e-1)" "unprognostic (1.69e-3)" "unprognostic (4.99e-3)" "unprognostic (1.52e-10)" "unprognostic (9.01e-2)" "unprognostic (2.56e-1)" "unprognostic (2.92e-4)" "unprognostic (1.25e-1)" 0.9 0.6 23.1 0.9 17.2 0.0 3.3 5.1 33.3 17.2 0.0 5.9 0.6 14.1 0.6 2.3 11.9 0.5 1.6 23.8 12.9 1.0 0.3 0.5 0.3 19.3 20.7 27.8 1.1 2.6 17.9 0.0 14.9 6.3 0.2 5.3 2.0 1.2 0.0 2.1 2.9 1.0 8.4 0.3 2.1 1.5 15.1 0.3 0.5 0.0 0.3 1.8 6.3 13.4 0.0 4.8 35.4 20.4 0.0 0.1 8.4 6.5 1.7 2.9 0.8 3.7 0.0 0.0 4.8 0.7 5.6 1.4 4.8 8.5 0.8 0.0 12.3 0.0 13.4 11.4 0.4 0.0 8.7 0.6 5.0 0.2 3.8 12.7 0.4 1.9 11.5 0.0 0.0 10.8 0.4 0.0 32.0 0.6 14.0 0.0 0.0 4.9 0.4 0.0 39.5 47.6 2.4 1.7 0.5 3.7 14.0 0.0 9.0 2.0 11.1 3.5 0.4 0.1 1.7 0.0 0.0 0.0 5.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 23.1 17.2 5.1 33.3 23.8 12.9 19.3 20.7 14.9 8.4 15.1 13.4 0.1 0.0 0.0 133.2 0.2 0.8 1.5 1.4 0.6 23.8 6.5 8.9 12.5 0.0 0.1 1.8 4.2 0.1 0.3 0.1 0.0 1.3 0.0 0.6 7.1 0.6 1.8 0.0 31.2 0.0 0.0 2.4 0.0 1.1 0.0 6.9 0.0 0.0 0.2 33.7 32.3 0.1 2.0 0.0 0.0 0.0 3.1 0.1 3.6 2.8 0.2 45.6 0.0 28.1 32.5 0.2 0.0 1.2 0.0 2.6 0.0 0.0 0.1 8.6 0.0 0.0 3.3 0.1 0.2 0.1 0.3 0.3 0.1 0.6 0.5 0.4 B4GALT1 "beta4Gal-T1, GGTB2" ENSG00000086062 "Beta-1,4-galactosyltransferase 1" P15291 9 33104082-33167356 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Congenital disorder of glycosylation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Langerhans cells: 333.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "plasmacytoid DC: 215.3" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HDLM-2: 346.6;SiHa: 635.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA010806, HPA010807" Enhanced Enhanced "Golgi apparatus" "Intracellular and membrane" NA NA 97000000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 29: Non-specific - Vesicular transport" "Cluster 20: HeLa - Mitochondria" "Cluster 30: Mammary glandular cells - Lactation" "Golgi apparatus" "HPA010806: AB_1078255, HPA010807: AB_1078254" "unprognostic (7.57e-2)" "unprognostic (1.24e-2)" "unprognostic (2.09e-1)" "prognostic favorable (6.85e-7)" "unprognostic (1.83e-2)" "unprognostic (9.94e-2)" "unprognostic (3.08e-2)" "prognostic unfavorable (1.25e-4)" "unprognostic (1.07e-1)" "unprognostic (5.45e-2)" "unprognostic (1.68e-3)" "unprognostic (2.78e-1)" "unprognostic (7.93e-3)" "unprognostic (4.98e-2)" "unprognostic (3.91e-2)" "unprognostic (7.07e-2)" "unprognostic (3.46e-2)" 52.4 39.2 5.6 43.9 5.1 80.2 91.1 7.3 6.4 64.9 17.9 38.0 21.9 35.7 35.7 49.7 49.3 47.8 55.4 5.4 6.8 42.1 89.4 50.1 33.3 8.6 6.4 77.4 43.9 77.1 21.2 52.9 7.7 38.8 34.3 26.2 70.3 34.0 30.9 35.8 28.1 55.2 8.1 39.7 52.1 38.3 8.3 26.8 60.8 16.7 41.2 79.4 44.9 9.4 99.1 71.8 13.1 18.1 64.9 113.7 235.9 100.6 125.7 59.5 58.8 44.0 112.1 37.8 62.4 147.3 77.2 51.9 13.7 124.5 59.4 346.6 13.6 21.6 277.6 34.1 127.4 17.9 35.0 128.0 218.1 68.0 82.2 127.6 64.0 11.5 24.9 45.5 57.0 86.1 16.3 35.4 8.1 54.1 21.8 21.0 12.2 25.1 177.0 84.6 9.8 12.7 635.5 122.2 25.8 40.4 154.8 32.3 59.9 42.2 49.4 137.2 39.8 7.6 17.9 23.3 131.0 24.2 15.8 30.6 33.2 20.3 45.2 30.5 59.2 87.1 30.4 40.7 23.3 69.9 17.9 23.3 96.5 72.4 24.8 215.3 22.0 24.0 5.6 5.1 7.3 6.4 5.4 6.8 8.6 6.4 7.7 8.1 8.3 9.4 104.4 86.6 71.9 3.3 112.0 141.9 53.0 59.2 75.7 3.8 215.8 66.7 37.2 88.6 59.5 167.3 20.9 94.9 206.2 146.1 15.6 78.2 21.9 108.6 39.7 60.6 8.4 12.8 4.1 125.9 155.8 99.9 80.0 163.7 36.8 19.6 91.1 195.4 53.9 0.0 4.5 64.0 24.4 82.3 333.3 11.1 50.7 129.0 96.0 33.7 31.3 7.7 39.1 3.0 1.0 157.8 57.4 44.4 116.4 89.0 23.9 57.7 33.8 40.1 52.6 80.0 50.8 6.4 13.8 86.1 108.4 173.9 92.7 33.9 41.6 93.2 B4GALT2 beta4Gal-T2 ENSG00000117411 "Beta-1,4-galactosyltransferase 2" O60909 1 43978943-43991170 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007620, HPA047739" Supported Supported "Golgi apparatus,Vesicles" NA NA 3100000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 7: Non-specific - Mitochondria" "Golgi apparatus, Vesicles" "HPA007620: AB_2667879, HPA047739: AB_2680141" "unprognostic (1.11e-1)" "unprognostic (1.82e-1)" "unprognostic (1.15e-1)" "unprognostic (7.59e-2)" "unprognostic (1.19e-1)" "unprognostic (2.35e-1)" "prognostic unfavorable (2.96e-5)" "unprognostic (1.12e-2)" "unprognostic (1.45e-1)" "unprognostic (2.08e-2)" "unprognostic (4.23e-3)" "unprognostic (7.58e-2)" "prognostic unfavorable (3.62e-5)" "unprognostic (6.54e-2)" "unprognostic (1.52e-1)" "unprognostic (7.66e-2)" "unprognostic (3.12e-3)" 29.0 19.0 61.4 13.0 55.0 6.6 24.6 48.0 70.1 28.4 44.0 43.7 12.5 31.0 9.6 32.4 20.0 14.9 40.8 58.4 51.6 24.6 38.8 19.6 5.9 53.6 53.6 19.6 51.5 14.2 24.7 10.1 53.0 31.2 10.2 8.9 27.3 23.8 61.0 32.8 15.2 26.3 52.6 12.0 22.4 22.6 55.2 3.1 14.3 33.2 6.8 37.0 26.8 52.6 61.6 38.4 45.3 76.0 51.3 54.5 37.8 54.2 55.9 54.8 50.9 30.4 51.4 38.4 31.6 112.3 52.5 39.9 36.8 72.8 14.0 39.6 80.2 23.2 37.8 66.9 43.2 20.6 0.8 47.0 79.1 39.3 71.4 55.3 65.5 15.9 51.7 25.3 46.7 45.3 15.3 18.6 65.6 35.7 56.7 44.3 48.2 62.7 33.9 29.3 72.7 58.5 31.1 89.4 38.5 16.9 38.6 17.5 39.3 90.8 102.4 63.8 78.5 7.6 17.8 15.9 40.4 16.9 64.6 0.0 0.0 0.0 0.0 0.0 0.6 0.2 0.1 0.2 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 61.4 55.0 48.0 70.1 58.4 51.6 53.6 53.6 53.0 52.6 55.2 52.6 9.7 0.0 8.8 7.5 2.2 7.8 10.3 10.8 1.8 13.3 15.0 18.9 14.0 7.2 7.4 14.7 4.2 2.0 1.2 10.2 1.9 13.3 16.4 6.2 16.2 10.4 16.3 1.3 8.0 20.6 8.0 15.2 13.7 8.7 0.0 23.8 6.1 18.7 2.3 18.5 5.6 22.6 2.0 1.0 3.3 6.7 16.4 1.5 3.6 1.0 1.6 15.0 0.0 5.0 9.8 27.3 6.1 12.4 5.0 25.9 6.4 8.8 4.4 12.2 6.6 9.8 14.3 6.2 15.6 7.6 12.6 0.5 1.7 21.1 15.3 16.1 B4GALT3 beta4Gal-T3 ENSG00000158850 "Beta-1,4-galactosyltransferase 3" O60512 1 161171310-161177968 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Plasma cells: 114.8;Syncytiotrophoblasts: 114.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-266/70: 246.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA010793 Approved Supported "Golgi apparatus,Cytosol" NA NA 130000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 18: Non-specific - Mitochondria" "Cluster 29: U-266 - Adaptive immune response" "Cluster 55: Plasma cells - Humoral immune response" "Golgi apparatus" Cytosol "HPA010793: AB_1078256" "unprognostic (5.67e-3)" "unprognostic (7.68e-3)" "unprognostic (1.20e-2)" "unprognostic (8.15e-3)" "unprognostic (3.91e-1)" "unprognostic (1.10e-2)" "prognostic unfavorable (5.87e-5)" "unprognostic (3.11e-2)" "unprognostic (3.13e-1)" "unprognostic (4.64e-2)" "unprognostic (1.41e-1)" "unprognostic (3.69e-1)" "prognostic unfavorable (7.12e-7)" "unprognostic (1.86e-1)" "unprognostic (1.56e-1)" "unprognostic (1.66e-1)" "unprognostic (1.38e-1)" 28.4 21.9 20.0 16.0 20.5 19.0 21.6 17.9 21.1 21.8 18.6 19.4 17.2 14.7 18.3 25.1 19.0 14.4 24.9 20.5 22.0 27.7 22.5 25.1 23.4 18.4 19.3 29.0 34.0 21.9 32.5 21.7 19.1 21.8 17.5 8.0 32.3 12.3 24.6 24.6 18.6 10.6 18.2 31.2 27.6 19.4 22.9 16.9 21.9 16.3 20.7 23.7 21.4 19.3 35.2 22.3 32.8 43.6 47.5 24.7 52.5 19.2 34.7 39.6 36.3 44.8 68.4 32.2 54.2 22.1 37.8 34.3 34.9 21.7 22.8 34.1 42.5 18.6 14.2 35.8 34.1 37.0 48.6 33.7 31.1 36.5 39.6 47.0 45.2 41.3 60.3 69.3 32.2 35.4 24.1 34.4 40.9 70.3 48.0 28.5 18.2 79.4 33.5 20.9 46.6 54.7 19.7 50.4 41.7 44.2 50.7 64.8 18.9 19.5 35.4 22.4 57.7 246.6 146.5 43.0 28.5 31.2 32.0 10.7 14.9 12.6 27.0 17.2 24.3 26.2 25.9 26.0 18.0 21.2 25.0 23.2 9.7 25.9 23.3 37.4 43.1 21.0 20.0 20.5 17.9 21.1 20.5 22.0 18.4 19.3 19.1 18.2 22.9 19.3 18.1 19.2 20.0 1.6 34.7 38.5 36.6 26.2 19.9 17.3 32.8 19.9 10.2 15.7 17.7 25.8 2.1 44.8 30.3 15.3 5.9 28.7 10.1 8.2 7.8 24.4 28.8 34.5 6.2 22.9 91.7 24.7 15.3 10.9 9.5 21.0 27.8 13.2 29.7 26.9 7.1 20.7 26.4 16.6 17.9 5.7 9.6 16.2 23.2 4.7 10.2 9.4 47.4 5.0 4.5 31.4 20.0 7.2 114.8 46.1 19.0 20.9 12.4 8.6 26.3 11.1 24.7 14.9 46.9 21.7 41.9 114.2 29.5 11.8 22.7 51.4 B4GALT4 beta4Gal-T4 ENSG00000121578 "Beta-1,4-galactosyltransferase 4" O60513 3 119211732-119240946 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "epididymis: 76.0" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 123.6;Urothelial cells: 171.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "BJ: 125.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA046819, HPA063546" Approved Supported "Golgi apparatus" "Intracellular and membrane" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 37: Intestine - Unknown function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Golgi apparatus" "HPA046819: AB_2679824, HPA063546: AB_2685036" "unprognostic (4.07e-2)" "unprognostic (1.78e-2)" "unprognostic (3.27e-2)" "unprognostic (1.14e-3)" "unprognostic (4.59e-2)" "unprognostic (1.20e-1)" "prognostic unfavorable (4.04e-4)" "unprognostic (6.30e-2)" "unprognostic (1.20e-1)" "unprognostic (3.58e-1)" "unprognostic (6.10e-3)" "unprognostic (2.26e-2)" "unprognostic (2.76e-2)" "unprognostic (1.21e-1)" "unprognostic (1.18e-1)" "unprognostic (2.37e-1)" "unprognostic (1.11e-1)" 12.4 9.1 6.8 10.7 8.4 20.1 11.1 6.5 8.1 16.4 8.7 30.6 28.6 14.8 76.0 17.7 21.8 33.2 12.9 7.0 6.9 24.1 16.6 9.9 9.9 6.9 6.7 18.4 19.5 15.1 18.2 25.7 6.9 13.7 35.2 9.9 12.2 14.7 6.3 14.1 32.5 13.6 7.0 9.4 29.3 8.3 7.5 7.4 16.4 6.5 11.5 37.6 10.5 7.2 60.1 100.3 12.8 9.8 36.0 31.1 65.3 125.8 54.4 54.4 56.2 65.4 18.3 11.8 23.9 61.3 32.2 78.6 20.7 15.0 59.9 23.5 6.8 15.1 20.3 31.7 25.3 8.9 15.7 21.2 21.4 23.0 19.3 21.6 5.8 8.0 11.2 11.7 25.5 18.4 5.3 10.7 17.6 34.0 27.2 4.9 11.8 4.7 31.2 60.3 10.9 24.0 29.4 14.6 27.9 28.2 30.2 5.7 4.9 27.3 24.0 15.2 13.5 27.2 21.5 16.1 23.5 10.1 23.5 20.1 4.1 8.3 13.3 5.2 7.3 4.2 7.3 7.9 5.5 3.2 13.6 7.1 2.5 14.8 5.0 3.4 2.7 5.7 6.8 8.4 6.5 8.1 7.0 6.9 6.9 6.7 6.9 7.0 7.5 7.2 8.5 0.0 9.4 7.2 17.1 10.7 22.2 48.9 12.0 10.8 14.9 12.4 9.2 61.5 69.1 7.3 4.2 36.2 46.0 43.2 1.9 30.7 2.1 40.1 16.9 8.4 13.8 7.8 11.9 33.2 123.6 24.0 36.2 74.5 13.3 35.0 3.9 10.8 14.4 18.5 11.1 78.7 16.2 9.8 14.8 2.4 14.9 14.9 14.2 6.5 10.9 22.2 39.1 10.6 10.2 40.5 50.2 28.2 27.4 30.7 59.3 22.6 52.6 10.2 19.7 13.9 16.9 1.7 8.4 14.0 10.5 52.3 23.1 20.0 23.6 171.6 B4GALT5 beta4GalT-V ENSG00000158470 "Beta-1,4-galactosyltransferase 5" O43286 20 49632945-49713878 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism, Sphingolipid metabolism" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Urothelial cells: 128.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 6.6" "Lineage enriched" "Detected in many" 4 "granulocytes: 6.6" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA077777 Approved Vesicles "Intracellular and membrane" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 1: K-562 - Erythropoiesis" "Cluster 44: Endometrium - Transcription" Vesicles "HPA077777: " "unprognostic (7.98e-2)" "unprognostic (5.27e-2)" "unprognostic (2.62e-1)" "unprognostic (1.88e-2)" "unprognostic (2.76e-1)" "unprognostic (1.61e-2)" "prognostic unfavorable (2.69e-5)" "unprognostic (1.73e-1)" "unprognostic (1.50e-1)" "unprognostic (1.39e-2)" "prognostic unfavorable (1.87e-5)" "unprognostic (1.04e-1)" "unprognostic (1.50e-1)" "unprognostic (3.30e-2)" "unprognostic (5.41e-1)" "unprognostic (2.07e-1)" "unprognostic (2.69e-2)" 28.7 47.8 14.7 21.7 14.5 93.7 18.6 14.6 16.1 21.2 6.5 24.9 25.3 23.5 8.6 37.3 18.5 31.5 20.5 15.5 18.1 22.8 25.8 27.3 9.6 14.7 19.2 19.0 12.6 11.3 12.6 27.2 15.4 17.1 23.7 7.7 19.0 21.9 67.1 7.9 21.3 37.6 14.6 27.6 25.8 22.3 19.0 8.1 11.5 24.3 11.5 51.4 17.2 12.0 48.8 55.0 71.4 30.4 72.8 49.3 62.4 23.5 43.7 104.8 50.0 71.1 59.0 14.8 98.0 39.0 99.1 75.4 45.5 35.0 61.3 45.6 12.5 39.4 28.8 42.9 22.9 51.6 73.7 74.3 32.2 45.5 21.8 96.5 64.8 25.9 64.5 8.9 30.8 24.1 3.1 47.3 37.4 47.8 35.3 26.6 61.9 21.4 50.6 34.0 84.9 43.0 83.6 105.3 47.8 52.5 24.1 70.0 50.1 62.7 50.5 33.6 49.8 10.9 10.0 35.2 32.6 48.5 40.7 1.4 1.0 2.6 1.4 1.0 1.5 0.2 0.6 1.3 0.7 0.3 0.1 0.9 6.6 1.2 1.1 0.6 0.8 0.4 14.7 14.5 14.6 16.1 15.5 18.1 14.7 19.2 15.4 14.6 19.0 12.0 39.5 16.0 43.1 36.2 5.8 18.9 27.3 39.7 7.4 8.3 17.3 18.2 18.3 42.9 84.5 36.8 10.4 23.4 21.3 61.3 1.9 35.3 5.2 59.1 28.4 42.7 34.3 33.2 52.1 19.7 27.7 27.3 17.9 100.8 83.2 36.2 58.5 22.7 24.5 11.8 59.5 21.3 40.7 28.2 81.5 6.8 19.9 45.0 21.4 30.9 21.4 5.6 20.6 25.6 42.5 39.7 34.1 32.7 7.3 66.8 13.4 33.5 57.0 4.9 26.3 29.9 25.9 10.3 16.0 27.5 17.5 5.6 17.4 33.1 20.0 128.9 B4GALT6 beta4GalT-VI ENSG00000118276 "Beta-1,4-galactosyltransferase 6" Q9UBX8 18 31622247-31685836 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism, Sphingolipid metabolism" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "retina: 25.3" "Group enriched" "Detected in many" 5 "Bipolar cells: 101.3;Cone photoreceptor cells: 39.6;Excitatory neurons: 71.5;Inhibitory neurons: 103.7;Oligodendrocyte precursor cells: 81.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in single" 4 "NK-cell: 1.2" "Lineage enriched" "Detected in single" 4 "NK-cells: 1.2" "Cell line enhanced" "Detected in many" "REH: 46.8;WM-115: 126.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB020701, HPA058284" Approved "Intracellular and membrane" NA NA "Cluster 40: NK-cells - Unknown function" "Cluster 58: Brain - Synaptic function" "Cluster 17: WM-115 - Nervous system development" "Cluster 56: Bipolar cells - Visual perception" "CAB020701: , HPA058284: AB_2683668" "unprognostic (3.79e-1)" "unprognostic (4.52e-1)" "unprognostic (6.54e-3)" "unprognostic (2.23e-4)" "unprognostic (1.05e-1)" "unprognostic (1.42e-1)" "unprognostic (1.31e-2)" "unprognostic (4.50e-2)" "unprognostic (5.18e-1)" "unprognostic (1.13e-1)" "prognostic favorable (5.65e-4)" "unprognostic (2.77e-1)" "prognostic favorable (6.40e-5)" "unprognostic (5.37e-1)" "unprognostic (1.52e-1)" "unprognostic (1.10e-2)" "unprognostic (4.00e-1)" 3.8 12.1 2.0 2.7 3.1 4.5 1.3 8.4 10.2 1.1 1.6 3.4 7.2 1.9 2.0 4.5 2.3 6.6 3.6 5.2 4.8 3.2 2.6 1.1 1.4 1.2 2.7 3.8 1.9 7.4 1.8 2.6 2.1 5.1 3.3 25.3 4.5 3.8 3.5 2.1 9.2 1.7 0.9 1.6 3.0 5.2 5.0 6.3 2.0 6.4 1.1 2.4 0.6 0.4 6.0 13.1 23.7 13.4 0.4 0.5 8.7 1.9 0.0 0.4 0.2 25.2 5.0 9.4 10.9 2.3 28.4 2.4 12.7 10.7 1.5 37.1 11.2 12.4 1.3 0.6 2.6 22.6 2.0 2.4 2.3 3.6 7.5 12.0 13.3 21.9 1.8 0.0 0.1 3.6 25.4 1.7 10.2 7.1 7.2 46.8 4.2 0.0 2.9 12.3 12.6 19.7 8.7 1.5 15.7 19.1 1.7 6.8 13.4 26.5 5.5 0.0 14.9 8.9 0.5 19.4 10.8 20.2 126.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.2 0.0 1.2 0.1 0.0 0.0 0.1 2.0 3.1 8.4 10.2 5.2 4.8 1.2 2.7 2.1 0.9 5.0 0.4 3.2 0.0 0.5 12.7 0.0 5.5 0.9 1.5 12.0 101.3 2.0 1.8 7.6 0.0 1.2 1.8 39.6 0.6 5.9 2.6 3.9 1.3 6.1 1.2 6.2 3.6 3.0 4.6 71.5 1.1 0.2 3.0 2.6 1.3 0.0 4.5 4.2 2.1 0.7 13.5 103.7 2.1 0.0 0.6 1.2 3.5 1.2 1.5 0.0 9.4 0.3 4.6 6.2 81.4 5.3 2.3 3.1 2.6 1.1 2.3 5.4 1.2 0.6 5.6 0.0 1.2 1.6 1.0 9.7 3.7 1.7 0.3 1.4 1.4 3.8 0.7 B4GALT7 "beta4Gal-T7, XGALT-1" ENSG00000027847 "Beta-1,4-galactosyltransferase 7" Q9UBV7 5 177600132-177610330 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Disease variant, Dwarfism, Ehlers-Danlos syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 132.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA042330 Supported NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 35: Non-specific - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 38: Extravillous trophoblasts - Unknown function" "HPA042330: AB_10796576" "unprognostic (1.19e-1)" "unprognostic (1.82e-1)" "unprognostic (3.12e-1)" "unprognostic (5.97e-2)" "prognostic unfavorable (2.29e-4)" "unprognostic (9.53e-2)" "unprognostic (4.19e-3)" "unprognostic (3.86e-2)" "unprognostic (1.18e-1)" "unprognostic (1.21e-1)" "unprognostic (1.82e-3)" "unprognostic (2.00e-2)" "unprognostic (4.81e-2)" "unprognostic (2.39e-1)" "unprognostic (4.44e-2)" "unprognostic (2.90e-1)" "unprognostic (4.00e-2)" 19.0 43.7 21.1 15.3 20.1 24.8 17.0 20.6 25.5 18.4 21.8 15.1 16.9 20.1 12.5 16.6 16.0 12.5 23.4 20.1 21.8 20.2 30.5 13.4 20.1 24.8 25.1 19.8 37.6 24.3 31.5 14.1 24.8 22.5 11.9 5.9 24.2 18.8 20.2 13.6 14.7 11.8 18.5 21.3 21.8 23.9 22.1 10.6 18.5 10.1 11.8 17.9 13.9 18.7 20.2 34.5 14.2 35.6 28.0 20.7 63.7 30.1 31.9 26.9 30.7 32.6 30.8 25.2 54.7 30.9 47.3 22.9 9.8 64.9 11.7 85.4 25.8 13.3 27.5 23.4 40.0 13.8 22.4 31.8 22.7 29.0 23.5 24.7 30.3 16.9 11.8 23.7 27.4 46.0 11.9 17.1 13.9 17.7 50.0 24.1 10.3 27.8 20.6 29.6 12.5 14.4 15.0 29.8 27.6 11.3 19.4 16.3 23.5 34.0 19.5 22.6 30.6 29.5 14.9 18.4 28.8 33.0 31.8 16.8 16.7 9.7 14.0 19.7 12.6 14.4 12.8 12.2 19.3 18.4 11.4 11.3 1.3 11.1 19.4 15.2 9.2 10.9 21.1 20.1 20.6 25.5 20.1 21.8 24.8 25.1 24.8 18.5 22.1 18.7 16.3 3.2 5.6 5.2 24.5 6.6 15.4 27.8 15.9 12.1 16.5 19.3 6.9 12.8 15.8 16.5 4.2 43.8 16.4 13.8 7.9 34.1 13.9 12.5 17.8 15.6 14.5 8.2 4.3 38.9 132.4 21.2 8.2 13.5 10.2 30.0 10.8 15.9 31.7 11.8 6.0 22.2 8.2 17.8 8.9 9.8 14.0 18.8 21.4 3.7 25.6 13.7 13.4 3.0 3.4 34.0 12.4 18.4 52.8 30.7 17.4 19.6 9.3 16.1 0.0 13.9 16.4 14.3 11.3 13.9 8.8 43.9 12.8 33.4 23.3 16.3 BAAT BAT ENSG00000136881 "Bile acid-CoA:amino acid N-acyltransferase" Q14032 9 101354182-101385400 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" "Acyltransferase, Hydrolase, Serine esterase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 41 "liver: 721.0" "Cell type enriched" "Detected in some" 10 "Hepatocytes: 996.7" "Cancer enriched" "Detected in many" 42 "liver cancer: 181.1" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 3.4;CACO-2: 1.6" "Not detected" "Not detected" "Not detected" "Not detected" "HPA021251, HPA021330" Enhanced Uncertain Vesicles NA NA 520000 "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 39: CACO-2 - Unknown function" "Cluster 2: Hepatocytes - Metabolism" Vesicles "HPA021251: AB_1845247, HPA021330: AB_2670674" "unprognostic (2.53e-2)" "unprognostic (1.81e-1)" "unprognostic (9.97e-2)" "unprognostic (9.33e-2)" "unprognostic (7.75e-3)" "unprognostic (4.68e-2)" "prognostic favorable (4.97e-4)" "unprognostic (2.14e-2)" "unprognostic (6.19e-2)" "unprognostic (4.43e-4)" "unprognostic (3.65e-1)" "unprognostic (2.15e-1)" "prognostic unfavorable (4.24e-7)" "unprognostic (1.74e-1)" "unprognostic (2.12e-1)" "unprognostic (2.17e-2)" "unprognostic (1.75e-1)" 0.1 0.0 0.5 0.0 0.5 1.2 0.0 0.5 1.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 17.4 0.1 0.5 0.4 0.3 721.0 0.4 0.0 0.4 0.3 0.0 0.9 0.0 0.0 0.0 0.5 0.0 0.0 0.2 0.0 0.0 1.1 0.0 0.1 0.0 0.1 0.2 0.0 0.0 0.3 0.0 0.0 0.7 0.0 0.0 0.0 0.8 0.0 3.4 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.1 1.6 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.8 0.0 0.2 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.2 0.3 0.1 0.0 0.1 0.1 0.1 0.4 0.8 0.2 0.0 0.3 0.0 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.5 0.5 1.0 0.5 0.4 0.4 0.3 0.5 0.1 0.3 0.8 0.3 0.0 0.0 0.7 2.4 0.0 0.1 0.0 0.0 1.1 0.3 0.1 0.7 91.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.2 0.1 0.0 0.1 0.7 0.0 16.0 9.7 0.2 0.0 0.1 0.0 0.1 0.0 0.0 12.1 996.7 0.0 0.0 7.2 0.0 0.0 18.2 0.0 0.0 0.0 0.1 0.0 1.9 0.0 0.1 0.0 3.0 0.9 1.8 0.1 0.0 0.0 0.0 0.3 0.3 0.0 0.2 0.0 0.5 0.1 0.3 0.2 0.0 0.0 0.0 1.0 0.1 0.4 0.0 BARD1 ENSG00000138376 "BRCA1 associated RING domain 1" Q99728 2 214725646-214809683 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 68.6;Basal prostatic cells: 62.2;Suprabasal keratinocytes: 74.4;Urothelial cells: 67.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB034106, HPA035354, HPA044864" Enhanced Supported "Nucleoplasm,Nuclear speckles,Cytoplasmic bodies" No Yes "Cluster 4: T-regs - Cell cycle regulation" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 22: Epithelial cell types - Mixed function" "Nucleoplasm, Nuclear speckles" "Cytoplasmic bodies" "CAB034106: AB_2061237, HPA035354: AB_2674585, HPA044864: AB_2679119" "unprognostic (4.85e-2)" "unprognostic (1.87e-2)" "unprognostic (1.74e-2)" "unprognostic (8.37e-3)" "unprognostic (2.57e-2)" "unprognostic (1.03e-2)" "unprognostic (6.25e-4)" "unprognostic (1.99e-1)" "unprognostic (2.16e-2)" "unprognostic (3.92e-3)" "unprognostic (2.80e-2)" "unprognostic (7.41e-2)" "unprognostic (1.94e-8)" "unprognostic (3.94e-2)" "unprognostic (2.28e-1)" "unprognostic (1.57e-1)" "unprognostic (1.08e-1)" 1.8 0.6 3.0 2.7 4.6 11.4 2.9 2.2 2.7 3.1 0.2 2.9 2.3 3.3 2.6 5.1 1.9 2.0 1.5 2.3 4.1 0.8 1.0 2.5 5.5 3.8 3.2 2.3 1.6 2.3 1.2 2.3 3.9 2.9 3.6 2.0 1.9 3.6 4.2 8.8 2.1 3.9 3.9 2.6 1.9 6.6 4.1 7.0 1.4 2.3 6.6 2.1 3.8 4.2 12.3 8.8 20.2 9.3 2.7 4.0 12.0 17.3 10.6 17.8 21.8 12.0 12.2 12.6 7.6 8.5 9.5 12.7 16.5 10.5 22.7 11.5 6.4 12.5 13.8 8.7 0.9 13.9 12.7 4.7 1.1 15.0 8.1 4.5 6.1 14.7 7.9 36.0 13.7 10.7 27.9 12.5 14.3 7.9 3.7 24.7 19.8 11.2 3.9 14.0 5.8 8.8 15.0 14.7 5.3 10.9 16.3 13.4 4.7 18.0 14.0 11.7 13.6 10.2 12.6 28.0 7.6 11.3 13.4 3.9 2.0 5.8 4.6 4.0 3.2 9.7 5.4 5.5 3.6 8.2 2.4 4.0 0.3 7.3 3.8 6.9 17.1 2.3 3.0 4.6 2.2 2.7 2.3 4.1 3.8 3.2 3.9 3.9 4.1 4.2 12.3 6.4 2.2 14.7 13.0 68.6 62.2 13.0 14.2 3.3 9.9 14.1 17.4 17.2 12.7 9.2 0.0 18.2 11.3 8.2 3.9 8.0 9.2 13.3 11.9 9.6 1.2 34.5 5.5 6.9 16.0 10.0 10.2 18.0 15.2 28.2 10.0 4.2 12.5 1.7 15.4 13.1 8.2 10.1 12.2 5.7 6.2 11.2 3.6 15.9 16.6 4.4 9.2 19.6 31.7 6.5 6.5 10.1 22.0 22.9 3.2 0.7 12.3 6.8 19.7 15.4 16.9 27.6 43.4 28.6 74.4 5.1 13.4 10.5 14.7 67.2 BAZ1B "WBSCR10, WBSCR9, WSTF" ENSG00000009954 "Bromodomain adjacent to zinc finger domain 1B" Q9UIG0 7 73440406-73522293 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, Transcription, Transcription regulation" "Kinase, Transferase, Tyrosine-protein kinase" "Williams-Beuren syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB037081, CAB037158, HPA058068" Supported Supported Nucleoplasm NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "CAB037081: AB_477637, CAB037158: AB_477636, HPA058068: " "unprognostic (1.17e-1)" "unprognostic (1.09e-1)" "unprognostic (1.07e-1)" "unprognostic (2.06e-2)" "unprognostic (1.37e-1)" "unprognostic (5.72e-2)" "unprognostic (1.10e-3)" "unprognostic (1.89e-1)" "unprognostic (1.09e-1)" "unprognostic (2.50e-2)" "unprognostic (1.53e-1)" "unprognostic (2.12e-1)" "unprognostic (7.13e-2)" "unprognostic (1.03e-1)" "unprognostic (4.41e-2)" "unprognostic (1.09e-1)" "unprognostic (3.16e-1)" 22.6 19.4 24.1 22.1 28.3 24.7 16.7 28.6 25.2 22.5 21.5 23.0 16.0 24.4 17.7 18.0 19.3 16.0 19.6 21.9 26.9 16.8 24.1 20.3 27.9 25.1 26.5 30.8 21.0 27.6 19.2 22.7 24.7 22.6 20.5 28.3 17.1 25.4 28.0 14.2 18.2 24.7 23.8 23.4 18.9 17.3 25.5 40.6 23.8 30.7 29.6 21.9 17.5 29.1 75.6 76.1 102.5 115.3 52.0 55.1 34.1 71.7 54.7 67.4 70.5 62.4 55.6 141.6 16.3 64.1 102.6 51.7 126.1 47.7 100.9 80.3 63.8 84.4 89.3 54.3 57.9 128.8 68.5 39.6 45.5 83.2 101.6 50.4 54.5 75.9 149.9 86.4 76.7 71.7 132.8 59.1 66.7 57.6 56.2 133.1 89.9 94.5 38.5 58.2 102.4 87.2 102.1 112.4 59.8 87.1 69.1 63.6 64.4 116.1 66.5 70.6 123.2 49.7 84.7 235.7 65.9 119.1 107.7 4.0 1.5 1.0 3.0 1.1 2.6 1.2 2.3 2.2 1.1 2.5 1.7 1.9 1.1 2.8 0.8 3.1 2.5 0.9 24.1 28.3 28.6 25.2 21.9 26.9 25.1 26.5 24.7 23.8 25.5 29.1 46.3 76.9 129.8 28.7 52.8 29.8 34.5 16.7 38.1 69.9 28.1 24.6 81.7 27.1 59.0 20.2 43.8 57.3 50.4 33.1 7.9 35.5 8.4 47.4 72.2 53.5 34.7 89.8 35.0 23.1 59.6 58.7 34.7 52.6 51.8 59.5 34.6 59.1 33.0 60.6 35.3 34.6 22.4 33.4 24.8 12.5 61.2 38.7 12.4 34.7 47.3 54.4 61.8 28.6 43.9 26.5 13.6 76.3 65.3 40.5 25.2 12.9 49.2 53.8 32.9 67.1 57.5 75.7 127.0 47.0 25.3 34.6 56.5 46.1 43.3 35.2 BCAT1 BCT1 ENSG00000060982 "Branched chain amino acid transaminase 1" P54687 12 24810024-24949101 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Amino-acid biosynthesis, Branched-chain amino acid biosynthesis" "Aminotransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "pancreas: 58.2" "Cell type enhanced" "Detected in many" "Bipolar cells: 203.2;Early spermatids: 161.4;Exocrine glandular cells: 139.9;Langerhans cells: 265.8;Late spermatids: 370.3" "Group enriched" "Detected in all" 4 "endometrial cancer: 19.0;glioma: 10.7;lung cancer: 7.2;ovarian cancer: 24.0;testis cancer: 27.4" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "non-classical monocyte: 17.1" "Group enriched" "Detected in many" 10 "dendritic cells: 5.8;monocytes: 17.1" "Cell line enhanced" "Detected in many" "HDLM-2: 261.3;NTERA-2: 287.4;RH-30: 310.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA048592 Uncertain NA NA 97000 "Cluster 14: Monocytes - Unknown function" "Cluster 22: Non-specific - Unknown function" "Cluster 5: NTERA-2 - Transcription" "Cluster 34: Spermatids - Unknown function" "HPA048592: AB_2680454" "unprognostic (1.90e-2)" "unprognostic (1.87e-3)" "unprognostic (1.37e-2)" "unprognostic (1.72e-1)" "unprognostic (1.27e-1)" "prognostic unfavorable (3.55e-4)" "unprognostic (3.05e-5)" "unprognostic (9.49e-3)" "unprognostic (4.22e-2)" "unprognostic (4.77e-3)" "unprognostic (1.97e-3)" "unprognostic (4.06e-1)" "prognostic unfavorable (1.38e-4)" "prognostic unfavorable (4.95e-4)" "unprognostic (5.44e-2)" "unprognostic (7.55e-2)" "prognostic unfavorable (8.54e-4)" 6.7 5.9 4.1 7.1 5.7 2.4 2.1 11.1 10.6 3.6 0.0 3.0 0.8 8.6 1.0 2.0 7.2 4.4 1.8 3.0 19.6 1.2 1.3 9.6 6.4 19.4 19.8 7.2 58.2 0.4 6.6 15.2 22.7 0.9 2.6 14.5 1.7 0.8 0.7 0.6 3.6 5.7 6.4 2.0 1.8 7.1 14.0 5.2 1.2 2.0 5.3 4.1 1.3 7.9 30.3 12.1 106.8 0.2 30.5 59.0 54.9 60.9 40.6 33.4 55.2 67.1 83.1 114.0 0.3 100.7 6.5 12.0 77.2 0.5 88.2 261.3 15.4 91.1 2.0 37.3 112.3 105.9 31.6 77.4 2.0 85.1 17.8 73.0 114.3 56.9 88.5 1.1 28.7 0.6 65.2 30.1 287.4 0.0 8.1 0.1 310.3 1.4 0.1 10.4 0.1 60.1 0.1 0.2 0.5 114.8 0.2 45.2 150.8 19.7 72.9 80.4 58.1 13.2 13.9 152.7 69.9 62.4 0.3 0.0 2.3 0.0 0.0 3.6 0.1 1.1 0.0 0.1 5.8 0.0 0.0 0.0 1.0 0.1 17.1 3.4 0.2 1.0 4.1 5.7 11.1 10.6 3.0 19.6 19.4 19.8 22.7 6.4 14.0 7.9 1.7 16.0 26.0 1.6 1.3 8.7 0.1 2.5 0.0 203.2 0.3 0.3 1.6 1.5 2.2 0.0 2.1 61.2 4.3 0.0 1.9 1.8 161.4 41.5 92.6 16.8 0.0 20.8 39.6 139.9 23.2 27.6 0.0 89.1 11.4 117.4 7.9 0.3 72.3 42.1 81.8 0.0 14.2 87.1 265.8 370.3 7.2 59.9 7.2 38.4 22.3 7.1 0.0 84.4 57.4 49.6 0.0 4.1 0.7 0.2 0.0 0.1 3.3 12.2 6.6 14.9 17.4 1.9 1.6 0.5 7.2 22.4 2.8 41.3 0.1 0.1 BCAT2 "BCAM, BCT2" ENSG00000105552 "Branched chain amino acid transaminase 2" O15382 19 48795062-48811029 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Amino-acid biosynthesis, Branched-chain amino acid biosynthesis" "Aminotransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RT4: 254.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA054091 Enhanced Approved Nucleoplasm,Mitochondria NA NA 25000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 15: RT4 - Unknown function" "Cluster 47: Cytotrophoblasts - Unknown function" "Nucleoplasm, Mitochondria" "HPA054091: AB_2682374" "unprognostic (2.58e-2)" "unprognostic (1.23e-2)" "unprognostic (2.16e-1)" "unprognostic (2.51e-3)" "unprognostic (1.54e-1)" "unprognostic (2.97e-2)" "unprognostic (1.69e-1)" "unprognostic (1.17e-2)" "unprognostic (2.98e-2)" "unprognostic (1.03e-1)" "unprognostic (8.32e-3)" "unprognostic (1.06e-1)" "prognostic favorable (3.68e-5)" "unprognostic (1.87e-3)" "unprognostic (1.35e-1)" "unprognostic (2.42e-1)" "unprognostic (7.50e-3)" 27.2 85.4 27.5 11.4 27.8 6.1 25.2 34.6 34.5 29.7 72.3 38.8 14.8 27.0 5.3 33.7 30.2 10.7 63.4 29.0 26.5 40.5 22.1 30.4 14.0 28.2 29.7 53.3 76.7 20.1 30.7 12.4 27.8 38.4 17.4 5.6 29.1 17.0 58.7 28.0 23.7 13.5 26.1 19.7 66.4 20.2 30.8 12.0 28.9 29.4 16.5 56.6 29.0 29.2 62.9 73.3 19.3 40.6 78.1 26.3 34.2 27.3 13.8 32.7 31.7 74.5 37.4 73.3 30.2 24.3 10.1 28.8 29.8 47.4 16.5 46.0 76.0 27.0 32.7 5.0 75.3 36.9 24.2 38.5 29.8 24.2 35.0 31.8 45.5 55.3 34.9 43.8 12.2 74.8 50.4 38.9 16.9 98.5 35.7 75.2 33.1 80.8 30.8 254.3 102.6 29.4 41.0 66.7 20.7 13.3 42.3 17.9 25.9 31.5 30.3 37.6 34.3 40.8 58.4 35.8 17.2 56.7 21.0 0.0 14.4 3.0 14.3 16.1 20.1 23.5 17.5 18.8 25.6 20.3 15.7 14.1 0.6 14.8 6.2 28.9 24.9 12.3 27.5 27.8 34.6 34.5 29.0 26.5 28.2 29.7 27.8 26.1 30.8 29.2 13.1 28.9 44.8 59.7 14.1 6.0 28.3 32.3 14.2 10.4 23.5 17.9 25.5 31.5 20.6 12.9 20.9 67.6 11.0 28.8 72.4 38.6 8.0 16.2 22.4 13.5 19.9 6.3 11.2 21.3 25.2 15.3 32.6 23.8 23.5 18.3 12.8 11.2 26.2 1.7 10.6 30.4 38.7 7.9 10.5 10.2 17.4 7.5 24.9 8.4 21.6 7.3 7.2 9.0 11.2 15.8 17.7 30.1 15.1 16.1 13.9 39.4 13.2 13.4 19.7 9.9 17.3 8.0 19.5 32.6 7.1 45.8 9.5 21.9 33.9 47.7 BCKDK ENSG00000103507 "Branched chain keto acid dehydrogenase kinase" O14874 16 31106107-31112791 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Transferase" "Autism, Autism spectrum disorder, Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Group enriched" "Detected in all" 4 "dendritic cells: 95.9;granulocytes: 89.7;monocytes: 115.0" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017995, HPA056067" Supported Supported Mitochondria NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 4: Macrophages - Innate immune response" Mitochondria "HPA017995: AB_1845309, HPA056067: AB_2683024" "unprognostic (1.37e-1)" "unprognostic (2.57e-1)" "unprognostic (6.94e-2)" "unprognostic (5.20e-2)" "unprognostic (5.39e-2)" "unprognostic (3.61e-2)" "unprognostic (1.01e-1)" "unprognostic (5.47e-2)" "unprognostic (1.60e-1)" "unprognostic (1.90e-1)" "unprognostic (1.35e-1)" "unprognostic (3.24e-2)" "unprognostic (2.66e-3)" "unprognostic (4.85e-2)" "unprognostic (3.93e-2)" "unprognostic (1.00e-1)" "unprognostic (4.97e-2)" 32.3 56.4 18.4 19.2 18.6 14.5 29.0 17.4 23.8 25.1 18.0 31.4 16.0 27.7 16.7 29.4 24.8 17.9 78.6 18.8 17.8 43.8 76.4 21.7 15.6 20.6 20.7 27.5 70.5 22.9 16.4 15.3 19.3 29.3 12.5 6.3 47.0 21.8 81.3 45.4 24.1 19.5 17.1 30.2 42.0 17.4 18.5 9.8 22.4 69.7 13.6 30.2 24.6 17.5 47.5 49.1 27.1 41.8 32.8 32.5 31.1 40.4 46.3 57.3 55.9 32.1 29.1 41.5 58.9 47.5 28.0 31.4 19.3 65.6 36.5 34.4 60.1 45.2 32.6 59.5 57.5 23.5 41.9 48.3 26.2 49.2 40.6 52.6 62.4 31.1 23.4 39.4 87.7 75.8 22.9 32.4 23.0 20.5 39.1 45.8 39.6 78.8 44.3 30.1 42.1 38.7 31.3 72.4 24.6 22.9 44.5 24.6 41.1 44.2 26.1 45.8 32.2 44.5 15.7 15.1 50.3 33.7 42.6 58.1 115.0 85.2 17.7 97.6 17.2 22.8 16.5 13.9 95.9 19.0 13.6 16.1 89.7 22.8 71.2 19.3 24.5 53.1 18.4 18.6 17.4 23.8 18.8 17.8 20.6 20.7 19.3 17.1 18.5 17.5 27.2 19.2 18.1 5.9 20.0 18.5 24.6 61.0 22.2 11.6 30.9 27.6 39.1 25.8 28.5 20.2 0.0 55.4 9.0 31.5 80.3 68.6 2.5 14.6 24.3 29.2 19.9 16.4 5.1 78.0 71.1 24.9 25.5 20.0 33.0 35.4 25.4 43.8 93.0 11.8 4.4 22.3 42.7 44.5 50.3 7.8 20.8 53.1 12.4 1.9 79.3 22.6 9.2 4.5 4.5 54.8 48.4 25.6 51.7 30.9 66.9 95.2 19.6 9.8 46.0 18.4 33.2 25.8 14.1 25.7 27.4 69.4 12.1 45.5 26.0 27.0 BCR "ALL, BCR1, CML, D22S11, D22S662, PHL" ENSG00000186716 "BCR activator of RhoGEF and GTPase" P11274 22 23179704-23318037 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "GTPase activation, Guanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 65.7" "Cell type enhanced" "Detected in many" "Hepatic stellate cells: 70.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "K-562: 112.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010421, CAB018545, HPA038337" Approved Approved "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 65: Brain - Ion transport" "Cluster 1: K-562 - Erythropoiesis" "Cluster 44: Endometrium - Transcription" "Plasma membrane, Cytosol" Nucleoplasm "CAB010421: AB_2274682, CAB018545: AB_2063918, HPA038337: AB_10675795" "unprognostic (7.46e-3)" "unprognostic (2.43e-2)" "unprognostic (2.15e-3)" "unprognostic (1.16e-1)" "unprognostic (5.35e-2)" "unprognostic (1.45e-1)" "unprognostic (5.08e-2)" "unprognostic (1.44e-1)" "unprognostic (7.55e-2)" "unprognostic (1.81e-1)" "unprognostic (9.46e-2)" "unprognostic (2.39e-2)" "prognostic favorable (9.15e-10)" "unprognostic (1.47e-1)" "unprognostic (7.10e-2)" "unprognostic (4.10e-2)" "unprognostic (7.43e-2)" 19.4 11.1 34.3 11.0 65.7 34.6 17.4 15.9 30.7 14.3 10.6 11.7 10.0 12.3 16.1 24.5 12.1 9.3 12.2 45.0 22.2 21.1 13.8 18.6 13.7 27.1 26.5 9.4 14.6 20.6 25.0 10.3 24.1 11.8 7.6 7.4 18.3 10.1 5.8 23.5 10.2 8.8 20.9 11.4 16.1 11.0 35.0 14.7 19.7 5.7 10.8 15.3 14.3 14.1 47.6 20.1 30.3 31.2 17.7 12.1 45.6 16.8 15.7 15.2 12.2 35.6 18.7 32.9 30.5 14.4 14.7 47.6 3.6 46.8 4.3 63.3 32.3 28.8 27.7 28.6 22.9 26.9 14.6 10.2 31.1 22.8 19.8 27.0 53.6 23.3 112.5 15.1 7.0 31.3 25.4 21.4 25.8 37.4 19.5 32.9 12.4 21.7 23.7 29.6 27.7 26.3 30.7 26.1 12.6 19.3 16.6 21.7 61.4 9.1 1.0 14.9 14.0 3.4 14.8 11.7 23.4 20.1 14.3 0.0 0.5 0.0 3.1 0.2 1.1 0.6 1.5 1.6 0.4 0.6 1.3 1.7 0.5 1.5 0.5 0.4 0.8 1.4 34.3 65.7 15.9 30.7 45.0 22.2 27.1 26.5 24.1 20.9 35.0 14.1 19.3 9.6 11.5 51.2 4.5 15.4 11.9 18.2 6.2 22.9 17.1 9.9 7.5 17.2 20.9 18.4 22.9 14.0 23.9 17.7 9.8 14.4 5.6 22.1 8.0 27.8 19.9 5.5 24.6 16.6 6.8 7.1 11.7 31.4 10.8 9.9 70.6 22.1 7.2 23.5 20.7 13.9 12.2 9.3 11.1 13.5 8.7 9.2 5.4 18.7 6.6 13.2 15.5 32.2 7.0 27.7 8.1 5.7 10.7 11.8 10.7 18.2 12.5 9.4 0.0 4.0 6.8 2.7 7.3 9.3 15.8 10.8 10.3 10.0 13.7 13.3 BHMT BHMT1 ENSG00000145692 "Betaine--homocysteine S-methyltransferase" Q93088 5 79111809-79132288 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 83 "kidney: 778.9;liver: 1141.8" "Group enriched" "Detected in some" 10 "Hepatocytes: 604.2;Proximal tubular cells: 996.1" "Group enriched" "Detected in some" 4 "liver cancer: 90.6;renal cancer: 50.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "Hep G2: 3.6;NTERA-2: 1.4" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" "HPA038285, HPA058310" Enhanced Supported Cytosol No NA 10000000 "Cluster 81: Kidney & Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Cytosol "HPA038285: AB_10675791, HPA058310: AB_2683675" "unprognostic (2.61e-2)" "unprognostic (4.12e-1)" "unprognostic (4.45e-1)" "unprognostic (4.14e-3)" "unprognostic (5.62e-2)" "unprognostic (4.14e-1)" "prognostic favorable (7.32e-4)" "unprognostic (5.33e-2)" "unprognostic (1.51e-1)" "unprognostic (1.13e-1)" "unprognostic (9.66e-4)" "unprognostic (6.42e-2)" "unprognostic (8.26e-3)" "unprognostic (1.77e-1)" "unprognostic (3.22e-1)" "unprognostic (3.60e-2)" "unprognostic (2.30e-3)" 0.7 0.3 0.3 0.0 0.8 0.0 0.5 0.0 0.5 0.3 0.1 0.6 1.2 0.2 1.8 0.1 0.2 0.2 0.2 0.5 0.3 778.9 1141.8 0.1 0.0 0.1 0.2 0.1 0.1 0.0 0.5 0.0 0.1 0.3 0.1 0.0 0.0 0.0 0.0 0.1 0.2 0.2 0.1 0.1 3.2 0.3 0.3 0.5 0.4 0.0 0.0 11.6 0.5 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 3.6 0.0 0.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.9 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.8 0.0 0.5 0.5 0.3 0.1 0.2 0.1 0.1 0.3 0.2 0.1 0.0 0.0 1.0 5.2 0.0 0.1 0.0 0.0 0.4 0.0 0.1 0.3 4.3 0.0 16.5 0.0 0.0 0.0 0.0 78.2 0.0 0.5 0.1 0.8 0.8 0.0 13.5 0.9 0.0 0.1 0.1 8.2 0.2 0.0 0.1 8.9 604.2 0.0 0.0 0.2 0.4 0.0 12.2 0.0 0.5 0.9 3.5 0.0 0.0 0.0 0.0 0.0 0.5 0.2 0.0 0.0 2.6 0.0 0.0 0.0 996.1 0.0 0.4 0.0 0.2 0.1 0.2 1.0 0.0 0.0 0.1 4.2 0.5 0.1 0.3 BHMT2 ENSG00000132840 "Betaine--homocysteine S-methyltransferase 2" Q9H2M3 5 79069767-79090069 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Methyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 10 "kidney: 333.1;liver: 429.9" "Cell type enhanced" "Detected in many" "Distal tubular cells: 95.9;Hepatocytes: 201.2;Proximal tubular cells: 408.6" "Group enriched" "Detected in many" 14 "liver cancer: 79.6;renal cancer: 52.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BJ hTERT+: 17.5;Hep G2: 78.2;hTEC/SVTERT24-B: 46.0;U-87 MG: 18.6" "Not detected" "Not detected" HPA044573 Enhanced NA NA 1900000 "Cluster 17: Basophils - Unknown function" "Cluster 81: Kidney & Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA044573: AB_10795044" "unprognostic (5.03e-2)" "unprognostic (4.42e-2)" "unprognostic (2.60e-2)" "unprognostic (3.76e-2)" "unprognostic (4.40e-2)" "unprognostic (2.90e-3)" "unprognostic (1.56e-2)" "unprognostic (1.95e-1)" "unprognostic (1.87e-2)" "unprognostic (2.45e-3)" "unprognostic (1.41e-2)" "unprognostic (1.02e-1)" "unprognostic (1.76e-2)" "unprognostic (5.05e-2)" "unprognostic (1.49e-1)" "unprognostic (1.60e-1)" "unprognostic (1.06e-3)" 31.3 16.6 5.6 3.0 6.0 0.3 15.5 4.5 5.0 8.5 14.2 15.7 1.7 12.1 37.6 7.6 7.6 7.4 13.6 4.9 7.3 333.1 429.9 3.1 1.3 5.2 7.0 7.8 1.8 0.5 12.3 0.4 6.2 12.0 2.4 1.3 2.1 14.4 10.2 2.4 6.1 13.0 4.7 0.6 9.1 3.8 6.9 0.9 18.8 4.8 1.0 18.1 3.8 4.7 0.0 0.2 0.1 0.1 8.5 6.0 2.8 7.8 17.5 4.0 7.7 0.0 0.1 0.1 0.1 9.7 0.0 0.1 0.0 0.0 5.7 0.0 0.0 0.4 0.4 78.2 6.6 0.4 0.1 7.3 0.0 46.0 0.0 7.9 0.0 0.0 0.4 0.4 1.1 0.0 0.1 0.3 0.1 0.0 0.2 0.1 0.5 0.1 0.0 0.2 2.2 0.1 0.5 0.0 0.1 0.5 0.1 0.2 0.0 0.3 0.1 0.3 0.1 0.1 0.1 0.3 18.6 0.4 0.1 0.7 0.0 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.0 0.1 0.1 0.1 0.8 0.3 0.0 0.1 0.0 0.0 5.6 6.0 4.5 5.0 4.9 7.3 5.2 7.0 6.2 4.7 6.9 4.7 1.4 6.4 0.5 6.2 1.2 0.8 0.4 0.1 0.0 1.5 0.2 0.1 4.4 1.5 0.0 46.0 2.1 0.2 0.0 0.0 95.9 0.1 0.5 0.4 11.7 2.9 1.2 2.7 4.1 0.0 0.4 17.3 0.0 0.4 0.0 4.5 2.5 201.2 0.3 0.0 0.6 0.1 0.0 4.4 1.2 1.3 27.4 2.5 0.0 11.2 0.3 4.2 0.0 2.0 0.6 0.0 0.0 37.2 0.1 0.4 0.0 408.6 0.1 1.2 6.6 6.2 3.1 0.4 0.5 0.1 1.0 0.3 2.2 30.0 0.0 1.0 BIRC2 "API1, c-IAP1, cIAP1, hiap-2, MIHB, RNF48" ENSG00000110330 "Baculoviral IAP repeat containing 2" Q13490 11 102347211-102378670 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Apoptosis, Transcription, Transcription regulation, Ubl conjugation pathway" "Activator, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005513, CAB020661" Supported Supported "Nucleoplasm,Nucleoli fibrillar center,Cytosol" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 34: Non-specific - Transcription" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 2: Hepatocytes - Metabolism" "Nucleoli fibrillar center, Cytosol" Nucleoplasm "CAB020661: , HPA005513: AB_1846746" "unprognostic (1.36e-1)" "unprognostic (3.29e-1)" "unprognostic (9.52e-3)" "unprognostic (1.62e-1)" "unprognostic (1.37e-1)" "unprognostic (7.02e-2)" "unprognostic (2.72e-2)" "unprognostic (1.04e-2)" "unprognostic (1.17e-2)" "unprognostic (9.59e-2)" "unprognostic (1.05e-2)" "unprognostic (3.02e-2)" "unprognostic (1.84e-2)" "unprognostic (1.07e-1)" "unprognostic (9.20e-2)" "unprognostic (5.00e-2)" "unprognostic (1.64e-2)" 23.2 27.6 18.4 25.8 19.6 36.4 28.2 20.0 23.4 27.5 22.5 27.2 23.6 25.7 30.2 18.1 19.7 24.8 23.6 17.9 19.9 28.8 44.3 22.6 34.5 19.7 19.4 21.8 33.7 20.4 18.8 29.4 19.8 21.4 26.0 22.2 21.1 16.1 29.7 18.2 25.2 21.6 20.1 26.7 23.5 24.6 18.8 50.6 22.2 32.9 27.1 30.4 20.4 24.9 34.0 24.7 37.3 29.3 46.1 63.3 23.9 128.3 48.8 71.9 43.4 30.9 81.7 37.1 123.5 59.2 40.3 36.7 24.5 33.8 85.7 50.0 12.6 37.2 17.6 37.8 46.9 22.9 23.0 40.8 64.4 41.2 52.3 66.2 50.1 22.2 34.4 0.2 131.0 10.9 24.3 20.1 18.1 40.1 23.7 11.9 48.4 24.9 55.4 38.5 15.5 20.3 44.7 26.9 40.7 56.7 42.5 27.3 82.7 150.7 34.4 46.2 84.2 14.9 21.9 25.0 32.6 28.2 112.5 97.2 43.3 104.4 22.9 42.2 18.9 15.7 21.5 21.3 33.8 15.1 27.4 27.7 67.6 34.3 46.7 20.4 33.2 27.5 18.4 19.6 20.0 23.4 17.9 19.9 19.7 19.4 19.8 20.1 18.8 24.9 61.8 41.7 41.1 17.0 52.6 67.2 109.2 53.6 39.9 24.4 52.3 52.8 58.6 67.2 49.5 64.4 29.2 38.4 77.9 85.7 43.0 49.8 20.8 63.2 54.0 51.0 48.5 80.0 22.4 73.7 27.8 55.9 28.5 85.7 62.7 43.7 59.3 182.1 41.5 20.2 21.7 54.3 46.8 84.3 71.5 11.2 36.4 71.1 51.6 26.2 81.2 34.3 55.6 21.6 33.1 54.5 71.1 29.0 49.2 75.0 82.1 110.1 56.6 31.0 26.3 45.7 48.9 44.7 42.4 28.4 62.8 35.2 57.1 36.4 44.2 82.5 BIRC3 "API2, c-IAP2, cIAP2, hiap-1, MALT2, MIHC, RNF49" ENSG00000023445 "Baculoviral IAP repeat containing 3" Q13489 11 102317450-102339403 "Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 89.0;lymphoid tissue: 141.5" "Cell type enhanced" "Detected in many" "granulocytes: 554.8;Langerhans cells: 1400.9;monocytes: 1117.0;Proximal enterocytes: 817.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "memory B-cell: 209.0;naive B-cell: 159.9" "Group enriched" "Detected in all" 13 "B-cells: 209.0;T-cells: 83.6" "Cell line enhanced" "Detected in many" "CAPAN-2: 146.5;Daudi: 140.7;EFO-21: 74.3;HDLM-2: 140.1;hTERT-HME1: 140.2;U-266/70: 89.2;U-266/84: 85.8" "Low region specificity" "Detected in all" HPA002317 Enhanced Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 37: B-cells - Transcription" "Cluster 16: Immune cells - Immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 3: Monocytes - Immune response regulation" "Nucleoplasm, Cytosol" "HPA002317: AB_1846748" "prognostic favorable (3.60e-4)" "unprognostic (2.89e-1)" "prognostic favorable (9.35e-4)" "unprognostic (3.28e-2)" "prognostic unfavorable (7.28e-4)" "unprognostic (5.83e-3)" "unprognostic (2.23e-1)" "unprognostic (3.88e-3)" "unprognostic (9.62e-2)" "unprognostic (1.29e-1)" "prognostic unfavorable (3.03e-4)" "unprognostic (3.21e-1)" "prognostic unfavorable (6.66e-6)" "unprognostic (6.42e-2)" "unprognostic (6.23e-3)" "unprognostic (1.00e-1)" "unprognostic (3.85e-2)" 9.0 14.7 2.7 104.8 2.9 26.3 18.4 1.6 3.4 19.1 3.4 24.9 26.6 10.5 3.7 16.0 8.5 51.0 7.7 2.8 3.5 12.6 26.3 24.6 141.5 2.6 2.7 6.6 12.0 4.3 3.6 5.3 2.3 10.6 24.7 0.6 12.7 11.4 2.7 8.1 89.0 10.7 2.5 73.2 54.3 8.2 2.7 59.2 3.9 4.3 134.4 46.9 4.8 3.6 26.4 24.5 0.2 0.4 0.7 3.9 2.4 2.5 17.5 3.3 3.7 4.6 146.5 140.7 74.3 1.4 22.8 13.0 0.1 4.6 7.8 140.1 0.3 0.5 7.3 1.4 30.7 2.4 3.7 3.5 18.1 8.4 140.2 4.9 0.4 10.2 0.5 0.0 3.0 0.1 8.3 1.3 0.3 14.2 1.0 0.1 0.8 6.8 34.3 12.9 0.1 0.3 2.1 2.1 1.8 0.5 6.4 1.8 7.5 25.6 3.4 1.4 28.3 89.2 85.8 48.8 4.0 7.4 3.0 8.6 3.9 2.2 5.8 10.1 9.8 209.0 41.7 14.1 3.6 159.9 28.4 8.3 2.6 9.9 11.0 1.7 83.6 11.9 2.7 2.9 1.6 3.4 2.8 3.5 2.6 2.7 2.3 2.5 2.7 3.6 41.2 144.2 70.8 0.0 420.1 101.2 324.9 267.2 51.2 0.3 26.6 22.9 12.5 134.4 146.9 40.5 0.0 2.0 71.2 142.4 7.9 230.3 1.8 231.3 16.8 101.4 15.0 23.6 1.1 179.7 0.5 63.4 184.5 289.4 554.8 1.8 6.4 4.4 11.7 0.0 3.2 38.0 75.3 25.4 1400.9 2.1 5.0 170.0 192.1 2.8 1117.0 0.5 14.4 0.0 0.4 207.4 281.1 2.2 288.4 455.1 817.3 19.5 88.1 0.0 0.0 60.8 90.9 0.7 0.5 31.8 84.5 0.5 278.0 0.7 49.4 193.3 BIRC6 BRUCE ENSG00000115760 "Baculoviral IAP repeat containing 6" Q9NR09 2 32357028-32618899 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle, Cell division, Mitosis, Ubl conjugation pathway" "Protease inhibitor, Thiol protease inhibitor, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 272.0;Inhibitory neurons: 291.3;Oligodendrocytes: 361.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 5 "basophil: 9.7" "Lineage enriched" "Detected in all" 5 "granulocytes: 9.7" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA074409, HPA074738" Approved Supported "Golgi apparatus,Vesicles,Mitotic spindle" Yes No "Cluster 18: Basophils - Vesicular transport" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 59: Non-specific - Transcription" "Golgi apparatus, Vesicles" "Mitotic spindle" "HPA074409: , HPA074738: AB_2686710" "unprognostic (3.38e-2)" "unprognostic (8.13e-3)" "unprognostic (8.88e-2)" "unprognostic (7.06e-3)" "unprognostic (6.69e-3)" "unprognostic (9.01e-2)" "unprognostic (4.51e-2)" "unprognostic (2.07e-1)" "unprognostic (1.32e-1)" "unprognostic (1.86e-1)" "unprognostic (4.49e-2)" "unprognostic (4.00e-2)" "unprognostic (2.07e-2)" "unprognostic (1.30e-1)" "unprognostic (4.61e-1)" "unprognostic (7.32e-2)" "unprognostic (3.37e-1)" 4.6 4.7 3.1 6.7 9.7 11.3 8.9 13.9 5.7 7.7 6.3 7.6 5.0 6.8 5.2 5.3 6.2 5.8 4.9 4.6 3.7 7.6 8.9 5.4 9.6 6.4 5.5 12.0 14.7 10.9 2.9 6.9 7.3 6.2 7.5 15.5 5.5 5.9 6.1 6.7 5.4 6.1 4.4 8.5 7.1 6.8 5.6 14.7 11.4 8.8 9.7 7.2 3.1 16.3 21.7 17.8 16.1 7.9 14.9 19.1 11.3 10.8 14.1 11.0 11.3 14.2 5.7 23.6 7.3 19.7 13.2 10.1 22.9 15.1 13.9 18.8 10.5 31.2 11.3 10.7 7.9 32.4 11.9 12.4 6.9 18.0 16.2 10.1 17.7 5.4 25.6 10.0 11.9 9.3 15.5 7.5 11.7 9.2 10.5 14.6 26.6 8.2 9.2 23.4 11.7 18.4 18.6 10.8 8.2 12.5 6.4 11.5 28.7 13.0 13.3 9.1 15.3 13.9 20.0 30.6 10.1 15.1 8.7 9.7 0.9 0.6 1.3 0.7 1.8 0.8 1.0 1.2 0.7 1.8 1.1 1.4 1.5 1.6 1.5 1.6 1.0 0.5 3.1 9.7 13.9 5.7 4.6 3.7 6.4 5.5 7.3 4.4 5.6 16.3 53.9 32.1 30.5 239.3 74.8 46.0 28.6 34.7 41.5 60.8 40.0 23.4 45.8 38.6 42.7 36.8 191.8 35.0 93.4 70.1 1.9 26.9 45.9 39.3 58.0 49.8 32.5 34.3 272.0 31.2 22.0 39.7 68.3 63.1 29.9 52.1 45.7 47.5 29.8 69.0 291.3 43.3 26.4 54.7 60.0 17.6 45.4 59.1 23.2 202.4 67.2 34.9 64.9 231.8 361.3 34.3 30.3 59.0 70.9 46.4 48.5 22.6 30.6 88.2 39.5 56.0 49.1 53.7 46.2 49.7 54.8 38.0 72.4 52.8 45.3 44.0 BIRC7 "KIAP, ML-IAP, mliap, RNF50" ENSG00000101197 "Baculoviral IAP repeat containing 7" Q96CA5 20 63235883-63240495 "Enzymes, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Protease inhibitor, Thiol protease inhibitor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "placenta: 6.5" "Cell type enhanced" "Detected in some" "Cytotrophoblasts: 12.4;Extravillous trophoblasts: 16.5;Hofbauer cells: 75.8;Melanocytes: 26.6;Muller glia cells: 54.2" "Cancer enriched" "Detected in many" 10 "melanoma: 73.7" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 5 "SK-MEL-30: 196.8" "Low region specificity" "Detected in some" "Not detected" "Not detected" "HPA047850, HPA061283" Enhanced Nucleoplasm,Centrosome,Cytosol NA NA "Cluster 32: T-cells - Unknown function" "Cluster 28: Placenta - Pregnancy" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 5: Muller glia cells - Visual perception" Nucleoplasm "Centrosome, Cytosol" "HPA047850: AB_2680181, HPA061283: " "unprognostic (3.60e-1)" "unprognostic (7.94e-2)" "unprognostic (2.70e-2)" "unprognostic (1.78e-3)" "unprognostic (1.15e-1)" "unprognostic (8.11e-2)" "unprognostic (1.69e-2)" "unprognostic (1.12e-1)" "unprognostic (1.62e-3)" "unprognostic (1.24e-2)" "unprognostic (6.90e-2)" "unprognostic (2.27e-1)" "unprognostic (8.82e-3)" "unprognostic (1.22e-2)" "unprognostic (4.77e-2)" "unprognostic (2.55e-2)" "unprognostic (4.84e-2)" 0.8 0.8 0.7 0.3 0.4 0.1 0.4 0.3 1.3 1.7 0.0 0.3 0.1 0.1 0.1 0.1 0.1 0.1 0.5 0.7 0.9 0.9 0.3 1.1 1.3 0.8 0.7 0.1 0.0 0.0 0.3 6.5 1.1 0.1 0.0 0.6 0.2 0.0 0.0 2.4 0.2 0.0 0.7 0.9 0.1 0.1 1.2 0.0 0.2 0.0 0.2 0.2 0.7 1.5 0.3 4.3 0.1 0.0 0.0 0.0 8.6 0.0 0.0 0.0 0.0 6.6 1.1 0.0 17.8 0.0 5.8 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.6 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.3 20.9 0.0 0.0 0.8 0.0 0.0 0.0 0.0 36.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 196.8 4.4 1.3 0.1 0.0 0.0 1.1 0.0 0.1 0.0 0.1 0.2 0.0 42.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.4 0.3 1.3 0.7 0.9 0.8 0.7 1.1 0.7 1.2 1.5 0.3 0.0 1.1 0.0 0.0 1.3 0.0 0.0 0.0 0.2 0.0 0.0 1.0 0.0 0.0 1.8 0.0 12.4 0.1 0.0 0.0 0.7 0.2 0.0 0.1 0.4 0.0 0.0 0.0 0.6 16.5 0.7 0.0 0.0 2.5 0.1 0.0 0.0 75.8 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 3.7 26.6 0.0 0.0 54.2 0.0 0.0 0.0 3.5 0.0 0.0 0.0 0.0 0.0 1.7 0.0 1.5 0.0 0.0 0.2 0.0 0.0 0.0 0.0 8.5 0.0 0.1 0.0 0.0 BLK MGC10442 ENSG00000136573 "BLK proto-oncogene, Src family tyrosine kinase" P51451 8 11486894-11564599 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Diabetes mellitus" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 16 "intestine: 39.1;lymphoid tissue: 46.7" "Cell type enriched" "Detected in some" 11 "B-cells: 116.0" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Group enriched" "Detected in many" 4 "memory B-cell: 183.4;naive B-cell: 131.5" "Lineage enriched" "Detected in many" 5 "B-cells: 183.4" "Cell line enhanced" "Detected in some" "Daudi: 106.6;REH: 29.9;RPMI-8226: 38.5;U-698: 48.6;U-87 MG: 22.7" "Not detected" "Not detected" "Not detected" "Not detected" "CAB005093, HPA069571" Approved Uncertain Nucleoplasm NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 16: Immune cells - Immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 57: B-cells - Immune response" Nucleoplasm "CAB005093: AB_2274756, HPA069571: AB_2732137" "unprognostic (6.50e-5)" "unprognostic (4.22e-3)" "unprognostic (5.64e-2)" "unprognostic (1.42e-1)" "unprognostic (3.45e-1)" "unprognostic (5.98e-6)" "unprognostic (1.59e-2)" "unprognostic (8.94e-4)" "unprognostic (1.02e-3)" "unprognostic (9.83e-3)" "unprognostic (1.22e-2)" "unprognostic (4.66e-2)" "unprognostic (9.05e-6)" "unprognostic (5.62e-2)" "unprognostic (5.43e-2)" "unprognostic (2.19e-1)" "unprognostic (1.16e-1)" 0.5 0.1 0.0 9.1 0.0 2.6 0.2 0.0 0.0 0.0 0.0 2.6 0.5 0.1 0.0 1.2 0.2 0.5 0.1 0.0 0.0 1.2 0.7 0.8 29.9 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.4 0.7 0.0 0.7 0.0 0.3 0.0 39.1 0.1 0.0 46.7 2.1 0.1 0.0 2.5 1.2 0.0 27.9 1.4 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 106.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.1 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.1 29.9 0.0 38.5 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 5.4 10.2 48.6 22.7 0.0 0.0 0.2 0.1 0.2 2.0 0.0 37.9 183.4 1.4 4.6 0.1 131.5 0.9 0.4 0.7 0.1 0.1 17.5 1.8 9.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 116.0 0.1 0.0 0.0 0.0 0.0 0.1 0.3 0.6 0.0 0.0 0.0 0.0 0.0 4.9 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 3.2 0.1 0.0 0.0 0.3 1.1 0.0 0.0 0.0 0.7 0.5 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.8 0.0 1.0 1.3 0.0 0.0 0.5 0.1 0.0 0.0 0.0 10.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.1 0.0 0.0 4.0 0.1 0.1 0.0 BMP2K "BIKe, DKFZp434K0614" ENSG00000138756 "BMP2 inducible kinase" Q9NSY1 4 78776342-78916365 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 242.9;granulocytes: 129.2;Hofbauer cells: 140.4;Microglial cells: 351.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in all" "fHDF/TERT166: 50.1;HEL: 73.6;HMC-1: 80.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026436, HPA026451, HPA026501" Approved Supported "Nuclear speckles" NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 4: Macrophages - Innate immune response" "Nuclear speckles" "HPA026436: AB_10600102, HPA026451: AB_10600228, HPA026501: AB_10601341" "unprognostic (7.96e-2)" "unprognostic (3.68e-1)" "prognostic favorable (1.74e-4)" "unprognostic (9.08e-2)" "unprognostic (1.97e-1)" "unprognostic (9.73e-3)" "unprognostic (1.51e-2)" "unprognostic (1.47e-1)" "unprognostic (2.98e-1)" "unprognostic (7.60e-2)" "unprognostic (1.39e-1)" "unprognostic (9.60e-2)" "unprognostic (9.90e-2)" "unprognostic (9.45e-2)" "unprognostic (1.59e-1)" "unprognostic (1.55e-2)" "unprognostic (3.18e-2)" 6.0 4.2 8.5 13.5 8.2 11.9 7.4 7.3 7.2 6.5 3.8 9.5 5.6 4.4 5.4 7.4 6.0 7.4 8.0 7.2 18.6 4.9 6.7 7.7 16.5 12.1 11.2 3.1 3.5 4.3 0.6 9.2 13.5 3.3 11.9 6.5 3.5 3.5 2.2 9.9 6.9 6.6 10.9 12.2 4.7 10.2 9.8 10.9 7.7 4.5 16.3 7.1 1.4 16.5 11.4 3.2 6.0 7.5 12.0 11.1 4.8 10.8 14.4 10.3 13.7 6.4 6.4 13.2 5.6 50.1 9.9 2.9 6.7 8.5 19.4 3.5 2.3 73.6 5.0 3.5 13.2 15.9 80.6 15.9 11.0 16.4 15.6 7.3 14.4 10.0 19.8 36.5 12.1 2.4 9.5 7.4 2.9 8.8 2.1 13.5 10.3 3.7 13.3 5.2 8.4 5.2 14.2 7.8 10.4 7.9 2.7 10.0 14.7 10.6 4.2 18.4 11.9 7.7 3.2 4.8 9.9 21.4 7.7 0.1 0.5 0.3 0.0 0.2 0.0 0.6 0.0 0.0 0.4 0.6 0.1 0.0 0.9 0.1 0.8 0.3 0.0 0.1 8.5 8.2 7.3 7.2 7.2 18.6 12.1 11.2 13.5 10.9 9.8 16.5 10.7 28.9 16.2 242.9 31.5 25.0 4.3 5.4 10.2 10.9 27.4 15.2 6.5 2.8 7.7 7.3 4.2 5.0 6.1 24.6 0.0 7.5 15.9 18.6 12.7 17.6 6.7 105.4 53.2 8.8 14.2 13.7 6.6 25.0 129.2 32.1 22.1 19.7 140.4 10.1 59.0 48.2 6.1 65.9 68.2 11.1 8.1 65.4 28.4 351.3 34.6 37.0 1.0 49.3 59.1 14.6 43.0 6.8 7.6 6.3 19.9 18.0 12.3 8.4 6.6 22.3 11.7 26.1 11.2 17.1 31.4 3.4 7.6 5.4 24.0 3.2 BMPR1A "ACVRLK3, ALK3, CD292" ENSG00000107779 "Bone morphogenetic protein receptor type 1A" P36894 10 86756601-86932825 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 142.7;Inhibitory neurons: 79.9;Oligodendrocyte precursor cells: 122.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB019398 Approved Approved Cytosol NA NA "Cluster 89: Fibroblasts - ECM organization" "Cluster 3: HMC-1 - Innate immune response" "Cluster 68: Oligodendrocytes - Mixed function" Cytosol "CAB019398: " "unprognostic (1.36e-1)" "unprognostic (2.46e-1)" "unprognostic (3.34e-1)" "unprognostic (9.61e-2)" "unprognostic (1.05e-3)" "unprognostic (9.34e-2)" "prognostic unfavorable (8.93e-4)" "unprognostic (3.64e-1)" "unprognostic (2.38e-2)" "unprognostic (1.53e-1)" "unprognostic (9.24e-2)" "unprognostic (9.42e-2)" "unprognostic (4.32e-2)" "unprognostic (1.80e-1)" "unprognostic (1.47e-1)" "unprognostic (1.01e-2)" "unprognostic (1.07e-1)" 9.1 6.4 4.3 4.5 5.2 0.0 10.3 5.4 5.5 8.1 4.9 9.9 5.4 12.9 11.9 7.8 7.4 9.6 7.8 4.7 6.1 7.0 4.3 7.3 2.9 6.8 5.8 11.6 5.8 9.9 2.6 6.5 6.3 12.5 8.2 4.8 12.1 13.0 7.9 9.3 8.6 12.5 6.2 2.9 7.3 5.2 4.6 2.9 19.1 4.8 3.0 7.9 4.1 6.5 14.6 7.8 27.6 26.8 15.0 10.6 5.5 14.5 18.3 9.4 11.3 11.0 13.1 4.7 6.1 19.2 5.9 15.0 15.8 14.3 14.1 5.5 8.2 5.9 6.9 19.0 10.2 7.4 37.7 10.7 8.5 11.2 9.5 13.9 0.0 8.1 7.6 2.7 12.3 7.0 6.7 7.8 17.6 5.2 4.2 0.0 12.3 0.1 18.9 12.1 3.7 12.8 17.8 8.4 12.6 34.1 15.0 4.1 6.2 7.0 9.8 12.7 13.3 0.3 12.3 5.3 6.5 5.6 6.0 0.3 0.0 0.0 0.3 0.0 0.2 0.3 0.2 0.2 0.0 0.1 0.1 0.2 0.2 0.1 0.0 0.1 0.1 0.0 4.3 5.2 5.4 5.5 4.7 6.1 6.8 5.8 6.3 6.2 4.6 6.5 3.5 35.3 22.4 142.7 3.5 12.1 7.1 9.9 17.6 7.5 10.2 10.2 22.6 18.6 10.5 11.0 20.9 14.1 2.3 10.7 1.9 10.6 0.7 10.7 19.7 4.5 18.0 0.0 63.8 9.5 1.0 20.6 19.4 13.9 15.2 22.9 9.3 7.2 3.4 11.8 79.9 13.9 8.2 4.8 6.1 4.1 33.5 2.3 8.8 34.7 0.8 12.9 2.1 122.2 64.3 8.9 4.9 31.2 3.2 13.7 10.6 5.5 16.5 20.4 6.6 20.3 19.2 2.1 6.6 11.5 9.8 5.1 4.3 11.9 11.1 6.7 BMPR1B "ALK6, CDw293" ENSG00000138696 "Bone morphogenetic protein receptor type 1B" O00238 4 94757955-95158448 "CD markers, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" Chondrogenesis "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Disease variant, Dwarfism" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 20.1;cervix: 24.7;prostate: 22.4" "Cell type enriched" "Detected in many" 7 "Astrocytes: 480.6" "Cancer enhanced" "Detected in many" "breast cancer: 32.4;prostate cancer: 24.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A549: 22.0;MCF7: 11.1;SH-SY5Y: 18.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 57: Non-specific - Angiogenesis" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 64: Astrocytes - Nervous system maintenance" "unprognostic (2.25e-1)" "unprognostic (1.80e-2)" "unprognostic (1.40e-3)" "prognostic favorable (2.84e-4)" "unprognostic (1.57e-1)" "unprognostic (4.22e-2)" "unprognostic (1.92e-1)" "unprognostic (2.86e-2)" "unprognostic (2.95e-2)" "unprognostic (1.01e-1)" "unprognostic (3.97e-2)" "unprognostic (3.93e-1)" "unprognostic (1.62e-3)" "unprognostic (7.89e-4)" "unprognostic (6.22e-2)" "unprognostic (3.81e-3)" "unprognostic (2.63e-2)" 0.7 4.6 13.4 0.3 15.4 0.1 1.0 13.5 15.0 24.7 2.1 0.9 0.1 4.4 2.4 0.2 12.5 2.6 0.8 12.5 16.0 7.8 0.8 1.7 0.0 19.3 20.1 6.2 1.1 0.1 1.9 0.7 17.5 22.4 0.2 8.1 1.0 14.2 3.0 0.8 0.1 0.6 15.3 0.9 2.4 3.7 15.6 6.4 0.5 1.1 0.0 0.2 0.5 12.1 0.0 22.0 5.6 0.0 2.3 4.8 0.2 0.1 0.0 0.1 0.5 0.0 0.1 0.0 0.2 1.0 0.0 1.3 3.6 8.4 0.1 0.0 4.9 0.0 1.4 0.0 0.6 0.5 0.1 2.7 9.0 2.8 6.2 0.4 0.1 0.0 0.0 0.0 7.1 11.1 0.6 0.1 2.1 0.1 3.2 0.2 3.4 0.1 4.3 0.1 0.2 18.8 0.3 3.2 3.2 0.8 1.7 0.0 0.0 4.0 3.8 0.2 4.3 0.0 0.0 0.0 1.5 0.0 0.5 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.2 0.0 13.4 15.4 13.5 15.0 12.5 16.0 19.3 20.1 17.5 15.3 15.6 12.1 0.0 6.4 0.0 480.6 0.0 2.7 1.3 13.1 1.2 0.4 3.8 1.0 3.4 2.8 33.4 60.7 0.0 0.0 0.0 0.0 1.9 3.0 1.4 28.5 1.4 1.1 18.4 0.0 51.0 0.4 0.3 1.5 0.0 20.8 0.0 38.6 2.9 0.0 0.1 0.0 2.5 0.0 8.2 0.0 1.2 1.4 3.1 0.4 28.4 22.5 0.0 38.5 0.0 10.1 2.8 0.7 0.0 3.8 0.0 28.5 0.0 0.2 15.7 1.6 0.0 1.7 2.9 1.2 10.6 0.4 2.3 0.0 0.5 4.4 0.0 1.6 BMPR2 "BMPR-II, BMPR3, BRK-3, PPH1, T-ALK" ENSG00000204217 "Bone morphogenetic protein receptor type 2" Q13873 2 202376327-202567751 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 202.2;Inhibitory neurons: 190.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017385, HPA049014" Approved Supported "Nucleoplasm,Plasma membrane" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 40: Granulosa cells - Unknown function" "Nucleoplasm, Plasma membrane" "HPA017385: AB_1845397, HPA049014: AB_2680599" "unprognostic (2.17e-1)" "unprognostic (9.00e-2)" "unprognostic (2.35e-1)" "unprognostic (2.73e-1)" "unprognostic (1.67e-1)" "unprognostic (2.55e-1)" "unprognostic (4.30e-2)" "unprognostic (1.11e-1)" "unprognostic (3.18e-2)" "unprognostic (1.10e-2)" "unprognostic (2.13e-2)" "unprognostic (1.97e-1)" "unprognostic (1.29e-2)" "unprognostic (1.21e-3)" "unprognostic (9.20e-2)" "unprognostic (1.18e-1)" "unprognostic (3.40e-1)" 18.5 21.6 8.2 10.9 14.1 2.2 13.2 3.2 16.8 22.6 0.3 13.6 8.5 20.0 11.3 12.4 14.9 17.3 21.5 16.0 14.8 17.4 15.6 29.1 7.2 6.2 7.7 16.8 10.4 17.5 8.5 34.0 10.0 17.1 13.0 26.7 11.0 13.9 10.9 10.9 8.6 24.3 3.9 13.1 11.7 11.3 10.6 9.0 18.2 23.1 9.4 20.6 12.4 5.9 13.3 12.3 12.6 19.7 34.2 31.9 23.8 27.2 28.3 23.6 23.9 10.8 19.6 4.7 30.7 58.2 19.9 24.5 16.8 21.4 41.6 13.8 11.2 14.2 12.6 16.8 22.7 4.0 10.7 24.2 21.5 17.1 22.8 40.6 73.9 5.6 9.3 22.5 33.8 24.8 3.4 3.6 6.9 6.6 11.1 9.1 24.3 7.1 21.3 27.9 12.6 12.7 28.9 17.7 32.7 32.0 13.2 9.5 75.9 48.0 24.4 16.3 16.7 3.1 4.1 1.3 11.3 9.0 13.9 0.1 0.6 0.2 0.9 0.5 0.6 0.3 0.3 0.5 0.6 0.4 0.7 0.3 0.1 0.3 0.9 0.7 1.0 0.3 8.2 14.1 3.2 16.8 16.0 14.8 6.2 7.7 10.0 3.9 10.6 5.9 116.9 105.8 40.3 104.5 15.2 33.4 18.0 34.9 13.6 54.3 29.2 29.7 55.5 15.7 38.8 20.2 81.3 16.9 17.8 25.2 1.9 27.2 2.8 23.1 54.5 152.2 25.1 6.9 202.2 28.1 22.6 47.7 16.8 36.4 23.5 155.1 143.1 19.9 18.7 35.3 190.2 16.3 20.3 24.2 31.7 4.6 33.8 23.5 42.7 170.5 20.2 39.9 16.5 152.8 55.1 46.8 21.1 42.9 9.5 23.9 16.4 12.4 28.0 31.7 65.7 48.8 62.4 33.2 25.0 21.2 35.9 20.0 13.1 0.8 15.5 24.8 BMX "ETK, PSCTK3" ENSG00000102010 "BMX non-receptor tyrosine kinase" P51813 X 15464246-15556529 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Cell adhesion, Stress response" "Kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 12 "epididymis: 102.6" "Group enriched" "Detected in some" 4 "Endothelial cells: 28.2;Hepatic stellate cells: 93.9" "Cancer enhanced" "Detected in many" "melanoma: 3.2" "Not detected" "Not detected" "Immune cell enriched" "Detected in single" 16 "neutrophil: 7.6" "Lineage enriched" "Detected in single" 77 "granulocytes: 7.6" "Cell line enriched" "Detected in some" 119 "HUVEC TERT2: 353.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA001048, CAB032495" Enhanced Supported "Nucleoplasm,Plasma membrane" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 30: Epididymis - Antimicrobial activity" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Plasma membrane" Nucleoplasm "CAB032495: AB_2290760, HPA001048: AB_1078289" "unprognostic (7.80e-2)" "unprognostic (4.92e-3)" "unprognostic (1.16e-2)" "unprognostic (4.07e-3)" "unprognostic (2.69e-1)" "unprognostic (2.14e-1)" "unprognostic (1.06e-3)" "unprognostic (2.36e-1)" "unprognostic (1.87e-1)" "unprognostic (1.21e-1)" "unprognostic (1.78e-1)" "unprognostic (1.06e-1)" "unprognostic (1.26e-2)" "unprognostic (1.84e-2)" "unprognostic (3.64e-2)" "unprognostic (1.26e-1)" "unprognostic (2.81e-2)" 7.7 0.3 0.3 1.7 0.5 7.1 4.9 0.3 0.6 1.7 1.1 3.8 4.4 2.3 102.6 2.3 2.6 2.6 8.8 0.3 0.3 0.6 0.7 3.0 1.5 0.3 0.4 0.9 0.9 0.3 0.2 4.7 0.3 0.9 2.4 0.0 1.1 0.9 1.3 1.6 4.8 2.6 0.3 2.2 1.4 0.2 0.4 0.7 2.0 2.2 0.4 2.6 2.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 353.0 0.0 0.2 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 2.9 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.6 0.0 0.0 0.0 0.0 0.0 0.3 0.5 0.3 0.6 0.3 0.3 0.3 0.4 0.3 0.3 0.4 0.4 14.1 0.0 1.1 1.3 0.0 0.4 0.7 0.0 0.0 0.0 0.1 0.0 1.6 0.0 0.0 1.8 0.0 0.1 0.0 0.1 0.0 0.0 0.0 3.2 0.0 28.2 4.2 3.2 1.3 0.2 0.0 1.1 4.6 0.2 0.0 0.1 93.9 0.7 0.1 0.0 1.2 0.1 2.0 0.0 1.1 0.0 0.3 0.1 0.0 1.0 0.0 0.0 0.0 0.5 1.5 0.0 0.0 0.0 0.1 0.8 0.1 0.0 0.8 0.0 0.0 0.3 0.8 0.2 0.1 0.2 0.0 0.1 0.2 0.1 0.4 0.4 BRAF BRAF1 ENSG00000157764 "B-Raf proto-oncogene, serine/threonine kinase" P15056 7 140719327-140924929 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Allosteric enzyme, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Cardiomyopathy, Deafness, Disease variant, Ectodermal dysplasia, FDA approved drug targets, Mental retardation, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 252.3;Inhibitory neurons: 242.4;Oligodendrocyte precursor cells: 206.1;Oligodendrocytes: 202.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001328, CAB004552, HPA071048" Approved Approved Vesicles,Cytosol No No "Cluster 15: NK-cells - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 29: U-266 - Adaptive immune response" "Cluster 52: Non-specific - Transcription" Vesicles Cytosol "CAB004552: AB_626760, HPA001328: AB_1078296, HPA071048: AB_2686336" "unprognostic (2.98e-3)" "unprognostic (5.66e-2)" "unprognostic (2.20e-2)" "unprognostic (2.66e-3)" "unprognostic (2.44e-1)" "unprognostic (1.48e-2)" "unprognostic (2.07e-2)" "unprognostic (4.23e-2)" "unprognostic (4.07e-2)" "unprognostic (1.58e-2)" "unprognostic (6.53e-2)" "unprognostic (1.91e-2)" "unprognostic (3.79e-3)" "unprognostic (2.08e-1)" "unprognostic (1.76e-1)" "unprognostic (8.01e-2)" "unprognostic (5.46e-2)" 8.8 5.8 6.3 5.6 7.7 15.9 8.8 12.5 8.7 8.2 5.4 8.6 4.7 8.3 8.3 7.5 8.0 5.8 7.6 8.3 6.7 7.6 6.6 9.9 6.9 4.0 3.6 9.8 8.3 11.5 9.0 7.2 4.6 8.2 5.4 17.0 7.2 5.9 8.6 10.4 6.9 6.0 3.1 6.7 7.8 13.7 5.2 8.7 10.2 8.4 6.4 9.9 8.5 6.7 6.3 5.2 7.7 9.4 9.1 11.8 12.3 6.8 7.5 5.4 7.6 5.7 6.7 10.8 5.0 7.3 8.4 3.4 6.8 5.5 10.0 9.8 5.4 7.1 5.1 5.2 7.6 11.7 6.8 7.9 6.1 6.0 12.0 8.2 6.6 7.7 11.3 19.1 9.8 3.3 15.6 12.0 6.9 6.2 3.1 10.1 6.5 8.9 5.3 11.9 8.9 7.3 7.9 4.9 7.3 7.5 4.5 7.8 9.7 5.9 4.3 12.9 5.5 21.6 12.9 16.7 9.7 11.3 6.6 1.9 1.0 4.1 1.5 0.9 1.0 1.3 1.5 1.2 0.8 1.1 2.6 1.3 2.0 3.5 1.3 1.0 1.5 0.6 6.3 7.7 12.5 8.7 8.3 6.7 4.0 3.6 4.6 3.1 5.2 6.7 43.4 22.4 45.7 151.1 58.4 21.5 24.6 6.0 23.3 29.7 31.2 21.2 19.8 10.0 18.7 25.8 35.5 15.7 73.5 8.8 7.9 14.3 68.6 50.6 37.4 23.4 19.2 14.9 252.3 9.8 12.9 22.0 21.9 69.2 24.7 45.5 9.3 9.6 9.4 25.2 242.4 9.8 8.2 13.6 37.1 36.5 16.4 30.1 16.0 126.5 14.6 11.3 15.5 206.1 202.6 15.4 8.1 10.1 48.7 23.8 8.0 13.4 20.0 33.0 6.6 24.1 24.7 43.8 26.0 14.5 24.0 75.5 41.4 30.9 8.7 33.4 BRAP "BRAP2, IMP, RNF52" ENSG00000089234 "BRCA1 associated protein" Q7Z569 12 111642146-111685956 "Enzymes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 67.2" "Group enriched" "Detected in all" 7 "Early spermatids: 319.6;Late spermatids: 380.1;Spermatocytes: 147.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040357, HPA058820" Approved Supported "Nuclear membrane,Cytosol" NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 31: Spermatids - Spermatogenesis" Cytosol "Nuclear membrane" "HPA040357: AB_10967924, HPA058820: AB_2683827" "unprognostic (7.02e-2)" "unprognostic (2.37e-3)" "unprognostic (5.33e-2)" "unprognostic (1.73e-1)" "unprognostic (1.70e-1)" "unprognostic (1.69e-1)" "prognostic unfavorable (7.65e-6)" "unprognostic (2.14e-1)" "unprognostic (9.24e-3)" "unprognostic (2.80e-1)" "unprognostic (1.81e-2)" "unprognostic (1.67e-1)" "unprognostic (1.19e-1)" "unprognostic (3.66e-2)" "unprognostic (1.58e-1)" "unprognostic (3.57e-2)" "unprognostic (8.08e-2)" 9.6 8.8 7.8 7.9 9.2 33.6 9.2 9.8 9.8 8.0 7.3 9.6 9.2 8.8 6.9 9.5 8.5 7.5 9.7 8.1 8.8 8.5 10.0 8.0 10.5 8.8 9.2 9.8 8.2 10.5 6.2 10.6 8.8 8.3 9.2 9.1 8.4 8.3 19.8 12.8 8.8 9.4 8.5 9.0 7.7 67.2 8.4 12.8 9.9 14.0 10.8 9.2 8.1 10.6 14.6 21.1 16.9 19.5 17.7 14.8 28.2 20.0 16.7 22.8 17.5 28.6 10.0 28.0 11.7 19.1 12.9 17.6 23.8 16.4 24.2 18.0 15.4 34.8 12.9 19.4 22.2 30.7 22.5 16.9 22.8 19.7 31.8 19.6 20.0 19.0 36.7 8.9 19.0 18.6 25.7 29.6 22.8 15.4 22.1 23.6 18.4 25.1 15.0 30.3 20.9 15.5 23.5 19.8 19.5 19.3 21.7 19.3 18.8 14.6 13.5 13.3 14.4 22.6 30.9 30.4 13.8 16.8 16.3 22.7 16.8 32.3 17.5 17.5 17.3 16.1 18.5 17.9 15.1 16.5 17.1 17.6 32.7 23.1 14.6 10.9 24.7 16.1 7.8 9.2 9.8 9.8 8.1 8.8 8.8 9.2 8.8 8.5 8.4 10.6 11.6 22.4 11.2 14.7 14.9 11.2 8.9 9.7 12.0 8.9 8.8 7.5 12.7 17.2 10.8 11.0 29.2 13.7 13.7 15.4 5.9 13.5 319.6 11.9 11.6 11.4 9.6 22.9 24.7 7.7 14.9 12.3 15.3 12.4 8.2 13.3 10.4 9.1 10.9 3.3 23.3 12.9 14.2 9.8 11.5 380.1 13.4 11.7 3.6 10.3 19.7 8.6 17.5 13.0 23.3 14.5 12.7 13.5 15.0 13.4 13.5 14.6 13.8 11.8 6.6 11.6 15.1 147.8 38.6 15.4 12.6 22.4 13.5 10.2 11.0 14.5 BRCA1 "BRCC1, FANCS, PPP1R53, RNF53" ENSG00000012048 "BRCA1 DNA repair associated" P38398 17 43044295-43170245 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, DNA damage, DNA recombination, DNA repair, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Transcription, Transcription regulation, Ubl conjugation pathway" "Activator, DNA-binding, Transferase" "Cancer-related genes, Disease variant, Fanconi anemia, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Erythroid cells: 42.5;Granulosa cells: 38.2;Spermatocytes: 105.8;Spermatogonia: 73.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "basophil: 6.8;classical monocyte: 14.7;intermediate monocyte: 4.7;myeloid DC: 10.9;neutrophil: 11.3" "Group enriched" "Detected in all" 6 "dendritic cells: 10.9;granulocytes: 11.3;monocytes: 14.7" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB001946, HPA004840, HPA034966, HPA057371" Approved Supported "Nucleoplasm,Nuclear bodies" NA Yes "Cluster 25: Monocytes - Inflammatory response" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" "Nucleoplasm, Nuclear bodies" "CAB001946: , HPA004840: , HPA034966: AB_10795287, HPA057371: AB_2732611" "unprognostic (7.87e-3)" "unprognostic (6.97e-2)" "unprognostic (3.53e-3)" "unprognostic (2.39e-1)" "unprognostic (5.42e-2)" "unprognostic (7.07e-3)" "unprognostic (1.56e-3)" "unprognostic (4.14e-3)" "unprognostic (9.62e-3)" "unprognostic (2.47e-1)" "unprognostic (5.53e-3)" "unprognostic (1.28e-1)" "unprognostic (1.08e-4)" "unprognostic (1.08e-3)" "unprognostic (1.48e-1)" "unprognostic (2.12e-1)" "unprognostic (8.31e-2)" 3.1 1.8 4.2 7.5 7.2 13.0 3.6 4.7 5.2 2.7 2.7 6.8 3.2 3.1 2.2 4.0 3.7 1.9 3.0 3.6 4.1 2.0 5.6 3.2 10.3 5.6 5.0 2.8 2.8 5.9 2.8 3.8 6.0 2.4 7.4 8.2 3.2 1.6 4.2 6.0 5.1 3.9 3.7 3.9 3.6 13.0 5.5 14.5 7.8 3.7 11.2 2.8 2.4 10.8 44.1 69.1 37.8 30.1 6.0 13.4 36.6 50.6 21.5 41.9 39.3 42.3 33.4 100.8 9.1 19.0 49.0 49.5 51.9 28.3 69.5 46.9 38.0 48.1 54.0 37.1 1.3 86.0 39.9 3.8 4.5 63.1 20.0 10.6 22.3 46.6 73.7 42.2 39.7 30.0 72.0 27.8 20.5 29.1 18.7 49.0 79.8 40.8 15.4 42.1 25.8 27.4 38.8 12.5 19.4 25.5 33.9 39.6 13.8 37.2 29.6 49.0 53.2 20.1 51.2 75.5 29.6 49.6 39.4 6.8 14.7 2.2 1.5 4.7 1.5 1.2 1.5 1.2 10.9 2.1 1.3 1.5 11.3 1.5 2.0 1.7 0.5 17.5 4.2 7.2 4.7 5.2 3.6 4.1 5.6 5.0 6.0 3.7 5.5 10.8 5.0 0.0 2.8 9.4 5.8 2.9 4.5 1.9 1.2 10.3 4.4 5.2 10.1 5.7 3.5 1.8 22.9 12.8 8.1 6.2 0.0 3.0 11.9 14.0 6.3 4.7 0.0 42.5 3.0 1.1 18.2 7.4 6.1 4.2 8.2 38.2 5.3 18.3 10.1 11.8 4.4 7.5 0.0 3.9 2.8 8.0 2.5 6.4 0.0 4.7 4.9 2.4 5.2 3.0 18.7 1.7 2.4 1.5 16.6 2.3 1.1 1.0 10.0 22.8 6.6 13.7 5.5 105.8 73.5 8.2 2.3 4.0 4.7 9.7 12.7 3.4 BRSK1 KIAA1811 ENSG00000160469 "BR serine/threonine kinase 1" Q8TDC3 19 55282072-55312562 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell cycle, DNA damage, Neurogenesis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "brain: 141.8;pituitary gland: 53.0" "Cell type enhanced" "Detected in many" "Bipolar cells: 34.8;Excitatory neurons: 30.1;Horizontal cells: 38.7;Inhibitory neurons: 27.6;Oligodendrocyte precursor cells: 17.1;Oligodendrocytes: 29.4;Proximal enterocytes: 23.6" "Cancer enhanced" "Detected in all" "glioma: 12.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "SCLC-21H: 56.4;SH-SY5Y: 51.8;WM-115: 46.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021212, HPA061719" Enhanced Supported "Nucleoplasm,Cell Junctions" NA NA "Cluster 65: Brain - Ion transport" "Cluster 17: WM-115 - Nervous system development" "Cluster 45: Enterocytes - Digestion" Nucleoplasm "Cell Junctions" "HPA021212: AB_1845455, HPA061719: AB_2684593" "unprognostic (1.42e-3)" "unprognostic (2.92e-2)" "unprognostic (1.20e-1)" "unprognostic (6.69e-3)" "unprognostic (2.71e-1)" "unprognostic (4.21e-2)" "unprognostic (3.06e-6)" "unprognostic (4.24e-1)" "unprognostic (2.06e-2)" "unprognostic (3.04e-1)" "prognostic favorable (1.02e-4)" "unprognostic (3.00e-1)" "prognostic unfavorable (7.98e-6)" "unprognostic (1.16e-1)" "unprognostic (6.61e-3)" "unprognostic (1.34e-1)" "unprognostic (2.09e-1)" 1.5 12.0 75.0 3.7 90.1 0.5 2.6 47.5 141.8 5.9 0.0 11.8 3.8 8.3 4.0 3.2 5.4 4.4 12.8 103.2 66.1 2.4 0.7 1.9 2.7 70.4 54.8 5.5 2.8 16.9 53.0 1.1 66.8 8.3 1.6 20.4 2.3 5.0 0.7 1.5 4.7 5.6 32.9 1.8 4.9 11.4 74.1 2.3 3.1 1.4 1.4 6.3 4.6 105.5 0.8 2.8 33.2 17.6 0.1 1.4 0.3 5.9 7.7 7.1 10.3 13.1 5.9 7.0 3.7 6.2 6.6 0.3 7.0 0.3 6.6 33.3 28.0 4.6 4.0 1.4 7.0 1.5 12.8 4.6 0.6 7.3 0.0 27.4 0.3 17.9 6.6 40.8 6.5 1.9 9.0 1.7 24.9 0.7 2.3 20.4 8.5 1.1 0.5 0.0 56.4 51.8 0.1 1.0 12.8 9.2 2.9 3.8 0.0 13.7 15.2 7.7 10.8 37.9 28.0 16.6 13.8 3.1 46.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 75.0 90.1 47.5 141.8 103.2 66.1 70.4 54.8 66.8 32.9 74.1 105.5 0.3 0.0 1.3 9.4 5.2 0.1 1.0 0.1 1.2 34.8 0.9 2.2 1.2 0.0 0.6 1.8 2.1 0.0 1.2 10.4 0.0 0.4 1.2 0.3 3.8 0.9 3.5 0.0 30.1 0.0 0.0 1.2 0.5 0.3 0.0 2.3 0.0 0.0 1.6 38.7 27.6 1.6 0.0 6.6 0.4 0.3 0.6 1.0 0.0 1.0 2.3 4.1 3.1 17.1 29.4 0.5 0.1 4.9 9.8 1.0 23.6 0.9 0.2 10.1 0.0 0.6 2.1 3.9 7.0 0.0 0.0 0.0 1.1 2.8 1.9 0.2 BRSK2 "C11orf7, PEN11B, STK29" ENSG00000174672 "BR serine/threonine kinase 2" Q8IWQ3 11 1389899-1462689 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Cell cycle, Cell division, Exocytosis, Mitosis, Neurogenesis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "brain: 37.8;pancreas: 104.2" "Cell type enhanced" "Detected in some" "Astrocytes: 22.9;Bipolar cells: 87.9;Cone photoreceptor cells: 35.5;Excitatory neurons: 35.5;Horizontal cells: 69.0;Inhibitory neurons: 23.5;Rod photoreceptor cells: 28.6" "Cancer enhanced" "Detected in many" "glioma: 3.7" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 15.8;AN3-CA: 17.3;CACO-2: 14.4;HAP1: 13.3;NTERA-2: 27.2;SCLC-21H: 62.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA073690 Approved "Golgi apparatus" NA NA "Cluster 22: Non-specific - Unknown function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 56: Bipolar cells - Visual perception" "Golgi apparatus" "HPA073690: " "unprognostic (5.47e-2)" "unprognostic (4.11e-2)" "unprognostic (1.26e-1)" "unprognostic (2.85e-2)" "unprognostic (1.18e-1)" "unprognostic (1.40e-2)" "unprognostic (1.05e-2)" "unprognostic (3.63e-1)" "unprognostic (6.42e-2)" "unprognostic (3.86e-2)" "unprognostic (2.22e-2)" "unprognostic (2.31e-1)" "unprognostic (3.17e-7)" "unprognostic (3.24e-2)" "unprognostic (1.57e-1)" "unprognostic (1.49e-3)" "unprognostic (1.86e-1)" 1.1 2.4 11.5 0.2 16.0 0.1 0.7 29.2 37.8 2.1 0.0 2.8 0.5 1.0 0.0 0.8 2.0 0.7 1.0 20.5 2.1 0.5 0.2 0.4 0.1 7.9 3.6 0.9 104.2 2.2 15.6 0.6 8.6 1.4 0.1 17.4 0.4 0.2 0.4 0.3 1.5 0.1 0.5 0.6 1.9 9.0 5.0 0.1 1.0 0.2 0.0 0.8 1.1 17.6 0.1 7.2 15.8 17.3 0.3 0.5 0.0 0.2 0.2 1.3 0.5 14.4 0.9 0.0 2.4 0.2 0.2 0.0 13.3 0.1 1.0 1.7 6.2 0.0 0.0 0.2 0.7 0.0 0.6 0.2 0.0 0.0 1.6 0.3 0.0 0.5 0.2 0.1 0.3 1.7 0.0 0.0 27.2 5.1 2.2 0.0 0.0 0.0 0.2 0.2 62.0 9.0 3.3 0.2 4.7 0.3 0.3 0.8 0.3 1.4 0.1 0.1 0.0 0.4 0.0 0.0 0.2 0.1 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.5 16.0 29.2 37.8 20.5 2.1 7.9 3.6 8.6 0.5 5.0 17.6 0.4 0.0 0.0 22.9 0.1 0.3 0.1 0.0 0.0 87.9 0.1 0.1 2.1 0.0 0.0 0.0 35.5 0.0 0.2 0.1 0.0 0.1 0.5 0.2 0.4 0.6 0.0 0.0 35.5 1.0 0.0 0.4 0.0 0.4 0.0 0.1 0.0 0.0 0.2 69.0 23.5 0.2 0.0 0.0 0.0 0.7 0.9 0.1 0.0 6.5 0.0 20.7 0.0 20.1 20.6 0.3 0.0 1.2 0.0 0.2 0.0 0.1 0.0 28.6 6.6 0.9 6.0 0.9 1.7 0.1 0.0 0.0 0.6 0.1 0.1 0.0 BTK "AGMX1, ATK, IMD1, PSCTK1, XLA" ENSG00000010671 "Bruton tyrosine kinase" Q06187 X 101349447-101390796 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Adaptive immunity, Apoptosis, Immunity, Innate immunity, Transcription, Transcription regulation" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, Dwarfism, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 32.6;lymphoid tissue: 78.0" "Cell type enhanced" "Detected in some" "B-cells: 84.7;granulocytes: 211.4;Hofbauer cells: 56.6;Kupffer cells: 63.5;Macrophages: 61.1;monocytes: 71.1;Plasma cells: 43.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 4 "basophil: 557.5" "Lineage enriched" "Detected in many" 4 "granulocytes: 557.5" "Cell line enhanced" "Detected in some" "Daudi: 206.7;HEL: 287.4;HMC-1: 990.3;U-937: 149.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA001198, HPA002028, CAB016689" Enhanced Supported "Plasma membrane,Cytosol" NA NA 2300000 "Cluster 38: Basophils - Unknown function" "Cluster 16: Immune cells - Immune response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 57: B-cells - Immune response" "Plasma membrane, Cytosol" "CAB016689: AB_1611894, HPA001198: AB_1078305, HPA002028: AB_1078306" "unprognostic (3.19e-2)" "unprognostic (2.51e-3)" "unprognostic (1.06e-2)" "unprognostic (3.66e-2)" "unprognostic (5.69e-2)" "unprognostic (3.76e-3)" "unprognostic (6.55e-2)" "unprognostic (3.58e-3)" "unprognostic (6.02e-2)" "unprognostic (3.12e-1)" "unprognostic (1.02e-1)" "unprognostic (1.41e-1)" "unprognostic (2.08e-3)" "unprognostic (7.80e-2)" "unprognostic (1.29e-2)" "unprognostic (1.56e-2)" "unprognostic (8.14e-2)" 6.3 2.9 2.3 30.7 2.6 32.6 4.4 2.8 3.4 3.9 3.1 6.6 4.8 2.5 1.5 3.6 1.9 7.6 1.6 2.3 3.1 1.3 5.4 19.6 55.5 4.7 3.6 0.8 1.2 0.9 0.9 7.0 4.7 1.9 9.1 0.3 2.8 2.3 0.6 2.9 14.7 7.1 3.8 38.4 7.0 1.4 3.9 9.3 1.3 2.0 78.0 9.3 1.5 6.5 0.1 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.1 0.0 0.0 206.7 0.0 0.0 0.1 0.5 0.0 0.0 0.1 0.0 0.3 287.4 0.0 0.0 0.0 116.7 990.3 0.0 0.0 0.1 0.0 0.0 0.0 0.2 61.9 2.3 0.0 0.0 0.6 81.5 1.6 0.0 0.0 87.2 0.1 13.2 0.0 0.0 0.2 0.0 0.3 0.1 0.5 1.0 0.0 68.5 0.4 0.0 0.3 0.2 0.1 2.6 1.4 98.3 0.5 149.8 0.3 557.5 62.2 110.5 0.2 99.9 0.2 72.4 0.2 0.1 72.7 73.0 0.4 0.1 24.7 0.2 123.9 33.1 0.1 38.4 2.3 2.6 2.8 3.4 2.3 3.1 4.7 3.6 4.7 3.8 3.9 6.5 1.5 3.2 8.9 0.3 84.7 1.0 0.2 0.0 0.6 0.0 0.9 1.4 0.6 0.0 0.6 0.0 0.0 1.4 30.1 0.1 0.0 0.0 0.2 1.3 0.3 0.8 0.0 27.1 0.5 0.0 0.5 0.9 1.1 2.3 211.4 0.0 0.7 0.3 56.6 0.0 0.3 0.3 0.0 63.5 31.0 0.1 0.3 61.1 3.6 10.3 71.1 0.0 2.1 0.0 0.1 0.1 0.5 0.0 43.8 0.0 0.0 0.3 0.0 0.0 0.0 0.2 0.5 0.7 1.7 0.5 0.3 1.9 5.7 0.2 0.1 0.1 BUB1 "BUB1A, BUB1L, hBUB1" ENSG00000169679 "BUB1 mitotic checkpoint serine/threonine kinase" O43683 2 110637528-110678063 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle, Cell division, Chromosome partition, Host-virus interaction, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "bone marrow: 11.9;lymphoid tissue: 27.5;testis: 30.3" "Cell type enhanced" "Detected in many" "Erythroid cells: 24.8;Granulosa cells: 66.1;Plasma cells: 35.2;Spermatocytes: 85.6;Spermatogonia: 20.0" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HEL: 221.5" "Region enhanced" "Detected in single" "white matter: 1.7" "Not detected" "Not detected" HPA006123 Supported Nucleoplasm,Cytosol NA Yes "Cluster 46: Basophils - DNA binding" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 36: HEL - Hemostasis" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm Cytosol "HPA006123: AB_1845498" "unprognostic (7.74e-2)" "unprognostic (3.45e-2)" "unprognostic (9.72e-3)" "prognostic unfavorable (3.65e-4)" "unprognostic (1.61e-1)" "unprognostic (5.62e-3)" "prognostic unfavorable (1.03e-5)" "prognostic unfavorable (3.94e-4)" "unprognostic (1.26e-3)" "unprognostic (1.15e-1)" "prognostic unfavorable (2.37e-5)" "unprognostic (1.76e-1)" "unprognostic (0.00e+0)" "unprognostic (2.45e-2)" "unprognostic (3.64e-1)" "unprognostic (5.01e-2)" "unprognostic (1.28e-1)" 0.5 0.4 0.1 8.4 0.3 11.9 1.2 0.1 0.1 0.9 0.0 4.3 4.0 1.0 3.5 4.7 0.5 0.9 0.6 0.1 0.1 0.3 0.6 1.2 15.9 0.1 0.6 0.4 0.2 0.7 0.0 3.2 0.3 0.3 5.7 0.1 0.9 0.1 0.1 2.7 3.5 2.2 0.0 5.6 1.9 30.3 0.4 27.5 0.4 0.2 17.0 2.4 1.6 0.3 96.0 29.4 68.5 46.8 3.8 5.3 38.8 50.9 32.9 85.6 62.3 58.3 55.0 64.7 30.9 30.1 80.1 43.2 93.9 35.0 105.7 51.4 45.6 221.5 26.2 50.6 0.8 63.5 57.0 1.7 2.8 65.2 33.1 12.7 49.8 73.2 96.8 126.5 76.8 33.7 126.3 39.0 71.2 39.4 55.3 69.3 64.2 102.7 18.3 27.0 48.3 21.4 34.2 31.4 27.2 44.1 24.0 60.6 19.1 39.7 57.5 28.8 69.0 67.3 65.5 75.4 24.2 48.6 69.8 1.1 0.0 0.2 0.2 0.0 0.3 0.5 0.9 0.5 0.1 0.5 0.6 0.4 0.0 0.5 0.0 0.9 1.5 0.3 0.1 0.3 0.1 0.1 0.1 0.1 0.1 0.6 0.3 0.0 0.4 0.3 0.2 0.0 1.5 0.0 5.5 0.5 0.5 2.0 0.6 0.0 0.9 0.8 1.1 0.0 1.6 0.0 0.0 5.8 2.5 2.4 0.0 0.3 13.5 4.5 1.5 1.1 0.0 24.8 0.2 0.0 9.8 2.2 2.0 2.2 0.0 66.1 1.8 0.3 8.1 0.0 0.2 3.1 4.1 1.6 1.4 7.5 0.3 2.0 0.0 0.0 0.6 0.0 0.0 0.5 1.0 0.1 0.0 0.4 35.2 0.5 0.3 0.1 1.8 0.0 6.6 0.2 3.7 85.6 20.0 4.0 0.4 0.7 2.9 0.5 5.9 0.9 BUB1B "Bub1A, BUBR1, MAD3L, SSK1" ENSG00000156970 "BUB1 mitotic checkpoint serine/threonine kinase B" O60566 15 40161023-40221123 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 17.8;lymphoid tissue: 35.7;testis: 22.2" "Cell type enhanced" "Detected in many" "Erythroid cells: 23.5;Spermatocytes: 79.2;Spermatogonia: 26.8" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "naive B-cell: 1.1" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in many" HPA008419 Supported Cytosol Yes Yes "Cluster 24: B-cells - Unknown function" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Cytosol "HPA008419: AB_1078308" "unprognostic (4.40e-2)" "unprognostic (2.23e-1)" "unprognostic (4.65e-2)" "unprognostic (2.44e-3)" "unprognostic (9.66e-2)" "unprognostic (3.52e-2)" "prognostic unfavorable (7.43e-6)" "prognostic unfavorable (3.56e-4)" "unprognostic (3.69e-3)" "unprognostic (2.32e-1)" "prognostic unfavorable (1.79e-4)" "unprognostic (1.76e-2)" "unprognostic (0.00e+0)" "unprognostic (3.75e-2)" "unprognostic (4.66e-2)" "unprognostic (2.20e-1)" "unprognostic (3.94e-2)" 0.4 0.5 0.1 6.7 0.1 17.8 1.6 0.3 0.2 1.0 7.7 4.6 4.7 1.2 0.3 5.2 0.6 0.6 0.3 0.3 0.1 0.3 0.4 1.0 12.6 0.0 0.1 0.2 0.2 0.2 0.1 3.4 0.1 0.4 6.0 0.1 0.9 0.2 0.0 3.5 4.1 2.1 0.0 3.1 2.4 22.2 0.2 35.7 0.5 0.0 15.0 1.5 1.7 0.0 66.5 32.8 103.0 41.5 2.5 7.1 33.2 60.9 34.2 64.6 55.7 48.1 25.0 59.7 33.5 22.7 59.0 72.6 98.8 33.2 70.5 51.8 52.1 86.4 83.6 45.5 0.2 79.0 45.7 1.6 2.0 39.2 37.1 12.9 47.7 66.5 76.4 61.7 65.6 22.5 62.5 48.9 70.2 55.6 36.8 66.5 83.7 45.2 19.9 33.1 67.1 40.8 38.0 35.9 13.3 45.1 41.9 40.9 27.6 49.3 51.8 49.2 55.5 32.1 58.2 95.6 26.3 87.8 65.4 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.2 0.1 0.2 1.1 0.0 0.1 0.0 0.1 0.0 0.8 0.0 0.1 0.1 0.1 0.3 0.2 0.3 0.1 0.0 0.1 0.1 0.0 0.2 0.0 0.1 3.2 1.1 0.3 1.8 0.8 0.3 1.0 1.8 0.7 0.9 2.0 0.8 0.0 1.9 0.0 0.0 5.4 0.6 1.8 0.0 0.4 3.0 0.9 1.4 1.0 0.0 23.5 0.7 0.0 6.7 2.4 5.6 2.1 0.0 12.9 1.1 0.3 5.2 0.0 0.7 2.5 0.0 1.9 1.7 3.3 1.5 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.6 1.5 0.4 12.6 0.3 0.3 0.1 0.2 0.2 6.6 0.2 1.7 79.2 26.8 6.9 0.3 0.8 1.8 0.8 5.4 0.6 C1GALT1 "C1GALT, T-synthase" ENSG00000106392 "Core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1" Q9NS00 7 7156934-7248616 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Angiogenesis, Differentiation" "Developmental protein, Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 204.3;Syncytiotrophoblasts: 204.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "LHCN-M2: 288.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA011294, HPA012819" Enhanced Approved "Nuclear bodies,Cytosol" NA NA 43000 "Cluster 2: Granulocytes - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" "Nuclear bodies, Cytosol" "HPA011294: AB_1845623, HPA012819: AB_1845624" "unprognostic (1.52e-1)" "prognostic unfavorable (1.04e-4)" "unprognostic (7.38e-2)" "unprognostic (8.78e-2)" "unprognostic (2.97e-2)" "unprognostic (1.04e-2)" "prognostic unfavorable (1.42e-5)" "unprognostic (2.03e-2)" "unprognostic (2.26e-1)" "unprognostic (1.17e-1)" "unprognostic (1.43e-1)" "unprognostic (1.40e-1)" "unprognostic (2.83e-1)" "unprognostic (3.28e-1)" "unprognostic (8.28e-2)" "unprognostic (1.08e-1)" "unprognostic (1.33e-1)" 12.9 7.2 12.8 14.2 17.7 37.7 16.6 16.1 15.5 18.5 25.0 15.2 29.4 5.6 6.4 21.6 16.2 16.6 12.6 11.3 13.7 30.8 22.0 15.0 19.1 17.7 15.6 4.6 6.1 45.8 8.6 27.0 17.7 5.1 18.0 23.6 23.3 6.8 7.5 8.8 19.3 7.3 17.9 15.5 22.4 7.3 14.2 14.3 12.5 11.3 14.0 13.0 7.3 24.6 63.5 25.9 9.6 16.0 28.1 57.0 28.0 71.5 60.7 32.4 51.1 20.0 63.9 33.4 17.0 31.7 93.5 18.3 14.0 27.5 58.3 15.1 8.1 31.1 15.9 62.3 28.1 34.3 13.2 44.0 20.0 75.7 70.0 47.4 30.3 29.9 61.0 19.9 288.7 10.5 8.8 22.8 51.7 47.8 20.3 29.6 53.1 19.3 46.6 32.4 9.9 27.2 46.9 57.0 52.8 57.5 15.6 19.6 30.4 55.2 76.7 74.7 31.3 34.4 28.7 32.9 36.9 42.9 55.8 56.0 12.9 38.4 17.7 20.2 19.7 20.4 16.6 20.6 15.1 16.6 17.7 19.4 29.1 22.7 34.0 16.4 16.2 14.1 12.8 17.7 16.1 15.5 11.3 13.7 17.7 15.6 17.7 17.9 14.2 24.6 23.2 41.7 54.2 32.3 57.1 26.3 17.0 48.4 29.0 28.1 24.5 10.8 24.0 25.8 40.6 18.4 33.3 91.9 44.8 29.9 5.9 29.1 17.2 28.4 8.7 12.7 15.6 49.7 44.3 25.3 81.1 26.0 41.3 31.7 12.0 36.2 13.9 23.5 38.2 47.1 42.5 18.8 30.5 21.1 20.5 19.9 6.5 33.0 23.2 65.6 21.9 22.9 49.4 52.3 204.3 46.2 22.6 6.4 43.2 14.5 27.7 40.0 29.7 34.8 6.6 17.2 15.3 16.6 35.6 46.4 19.5 204.8 39.6 8.9 26.7 25.7 CAD GATD4 ENSG00000084774 "Carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase" P27708 2 27217369-27243943 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Pyrimidine biosynthesis" "Allosteric enzyme, Hydrolase, Ligase, Multifunctional enzyme, Transferase" "Cancer-related genes, Congenital disorder of glycosylation, Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007781, HPA065158, HPA069341" Supported Supported Cytosol NA No 260000 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 18: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 52: Non-specific - Transcription" Cytosol "CAB007781: AB_562057, HPA065158: , HPA069341: AB_2686125" "unprognostic (1.69e-1)" "unprognostic (7.34e-2)" "unprognostic (1.49e-1)" "unprognostic (4.71e-3)" "unprognostic (2.55e-1)" "unprognostic (1.92e-1)" "prognostic unfavorable (1.72e-11)" "unprognostic (1.25e-1)" "unprognostic (2.22e-1)" "unprognostic (2.37e-1)" "unprognostic (1.01e-1)" "unprognostic (6.11e-2)" "prognostic unfavorable (1.82e-4)" "unprognostic (6.94e-2)" "unprognostic (1.75e-1)" "unprognostic (1.14e-1)" "unprognostic (5.93e-3)" 15.0 13.5 12.7 12.4 14.1 9.0 14.9 12.7 15.5 19.8 12.2 16.5 8.5 23.8 9.9 19.2 19.3 7.7 11.6 12.3 12.8 18.0 27.8 12.3 14.9 13.8 13.5 22.3 22.3 5.9 18.7 7.5 14.5 15.2 7.8 5.0 12.3 8.8 10.3 18.7 16.1 11.9 12.7 20.1 14.0 22.2 14.2 11.6 15.8 5.9 10.5 16.9 15.8 15.2 75.2 66.4 28.9 58.4 46.1 37.6 22.9 31.0 21.4 38.3 27.0 75.7 29.2 66.4 27.4 28.5 29.6 41.4 85.7 41.1 28.5 43.8 69.2 95.2 55.0 40.0 23.0 75.7 46.2 28.8 33.1 55.7 63.0 17.8 41.6 60.6 68.3 36.0 34.2 74.8 48.7 112.0 69.7 31.3 49.7 84.0 86.5 69.5 28.6 37.6 57.9 29.1 43.3 30.5 37.4 21.3 23.9 31.3 37.7 57.7 47.5 45.5 63.5 74.0 51.8 135.2 23.3 71.7 51.0 0.0 0.8 0.4 3.1 1.5 2.5 3.4 4.4 5.2 1.9 3.1 2.8 2.8 0.5 2.7 0.9 3.4 5.9 2.0 12.7 14.1 12.7 15.5 12.3 12.8 13.8 13.5 14.5 12.7 14.2 15.2 4.2 3.2 3.9 12.7 5.3 3.7 4.3 5.0 5.7 10.6 7.1 8.6 8.3 10.0 4.7 1.8 16.7 5.9 3.9 3.9 0.0 6.1 1.5 2.9 7.9 5.1 6.6 9.7 5.6 3.7 6.6 7.0 6.1 4.3 4.5 16.9 3.3 6.6 7.7 6.7 5.7 5.8 0.0 3.0 1.9 1.9 6.2 3.6 3.6 6.5 4.7 4.1 5.2 8.5 7.4 5.9 1.9 9.8 7.3 8.0 2.5 2.0 3.5 6.8 0.0 8.2 5.2 5.6 12.1 6.2 3.4 2.2 5.1 9.7 7.5 2.2 CAMK1 "CaMKI, CaMKI-alpha" ENSG00000134072 "Calcium/calmodulin dependent protein kinase I" Q14012 3 9757347-9769992 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell cycle, Differentiation, Neurogenesis" "Allosteric enzyme, Calmodulin-binding, Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Adipocytes: 58.3;Hofbauer cells: 76.2;Macrophages: 71.2;Sertoli cells: 59.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 7 "eosinophil: 280.5" "Lineage enriched" "Detected in many" 7 "granulocytes: 280.5" "Cell line enriched" "Detected in many" 4 "HMC-1: 403.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB031904, HPA051409" Approved Approved Cytosol NA NA 110000 "Cluster 52: Eosinophils - Transcription" "Cluster 35: Non-specific - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 4: Macrophages - Innate immune response" Cytosol "CAB031904: AB_630964, HPA051409: AB_2681473" "unprognostic (4.43e-2)" "unprognostic (3.05e-1)" "unprognostic (1.68e-1)" "unprognostic (1.29e-1)" "unprognostic (1.11e-1)" "unprognostic (3.06e-2)" "prognostic unfavorable (7.52e-4)" "unprognostic (5.53e-2)" "unprognostic (3.32e-1)" "unprognostic (9.74e-2)" "unprognostic (1.37e-3)" "unprognostic (2.17e-1)" "unprognostic (1.14e-3)" "unprognostic (7.76e-2)" "unprognostic (1.72e-1)" "unprognostic (3.67e-2)" "unprognostic (3.01e-1)" 52.4 99.7 50.1 17.2 48.9 5.1 37.2 39.9 61.0 27.0 31.8 33.6 9.2 31.8 13.7 8.0 37.0 11.1 20.5 61.2 46.3 24.9 36.4 23.9 11.1 37.8 41.7 41.2 8.4 14.4 21.6 6.7 38.8 31.1 10.6 5.9 9.8 19.7 7.1 7.9 16.5 26.0 36.8 16.7 21.7 29.8 46.9 4.3 19.5 7.8 15.0 28.4 18.3 46.1 0.5 16.4 12.6 0.0 64.7 24.3 32.6 38.4 21.1 43.1 40.4 24.1 3.0 1.1 9.0 26.0 6.2 2.7 0.0 5.0 27.0 0.4 95.4 53.5 32.1 34.1 35.9 4.5 403.3 25.3 4.1 60.6 6.7 35.4 36.8 0.9 7.2 1.2 16.3 10.3 0.3 38.8 9.0 0.4 25.7 0.3 0.4 1.1 25.9 2.8 4.2 16.7 6.6 0.7 4.0 5.3 4.1 67.2 19.6 19.8 24.4 28.0 48.7 0.4 0.3 1.0 41.5 14.7 3.0 17.8 21.3 280.5 0.3 42.2 0.1 0.1 0.4 0.2 14.1 0.2 0.3 0.1 1.0 3.6 43.0 0.4 2.0 4.7 50.1 48.9 39.9 61.0 61.2 46.3 37.8 41.7 38.8 36.8 46.9 46.1 58.3 0.0 3.1 17.9 2.8 5.0 19.2 3.4 5.7 9.9 5.2 4.6 0.1 12.8 2.1 11.0 2.1 0.4 3.0 2.6 9.8 14.4 1.8 1.8 14.9 22.8 6.0 4.8 25.6 4.0 1.2 23.3 5.6 3.1 30.5 16.7 30.4 23.5 76.2 0.0 14.5 2.3 0.0 46.4 40.2 7.2 36.1 71.2 5.4 8.4 36.7 39.4 3.1 6.6 2.7 5.5 2.9 45.1 0.2 17.5 3.6 47.4 1.3 7.7 59.2 12.2 42.7 1.5 3.7 1.5 3.8 0.8 7.1 6.6 7.6 11.0 CAMK1D CKLiK ENSG00000183049 "Calcium/calmodulin dependent protein kinase ID" Q8IU85 10 12349547-12835545 "Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Inflammatory response, Neurogenesis" "Allosteric enzyme, Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "retina: 57.9" "Cell type enhanced" "Detected in many" "Bipolar cells: 167.4;Cone photoreceptor cells: 392.0;Excitatory neurons: 416.9;Inhibitory neurons: 233.6;Microglial cells: 168.6;Rod photoreceptor cells: 214.2" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in many" 5 "amygdala: 14.9;basal ganglia: 16.7;cerebral cortex: 35.6;hippocampal formation: 29.6;white matter: 14.5" "Immune cell enhanced" "Detected in all" "eosinophil: 75.1" "Lineage enriched" "Detected in all" 5 "granulocytes: 75.1" "Cell line enhanced" "Detected in many" "HDLM-2: 113.8;U-266/70: 50.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007266 Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 58: Brain - Synaptic function" "Cluster 44: HDLM-2 - Immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoplasm, Cytosol" "HPA007266: AB_1078389" "unprognostic (1.06e-1)" "unprognostic (2.19e-2)" "unprognostic (2.77e-1)" "unprognostic (3.65e-3)" "unprognostic (4.23e-1)" "unprognostic (2.32e-2)" "unprognostic (6.90e-3)" "prognostic favorable (1.67e-4)" "unprognostic (1.06e-1)" "unprognostic (1.49e-2)" "unprognostic (2.95e-1)" "unprognostic (7.40e-2)" "unprognostic (1.35e-2)" "unprognostic (6.55e-2)" "unprognostic (1.65e-1)" "unprognostic (4.66e-2)" "unprognostic (2.56e-3)" 6.6 4.8 14.9 8.4 16.7 6.8 4.3 4.5 35.6 7.4 1.1 11.4 3.5 3.2 2.8 8.6 3.8 5.9 14.6 29.6 0.6 2.6 8.2 7.5 9.6 3.7 0.1 2.7 16.9 0.9 2.8 2.9 0.0 4.7 12.4 57.9 4.3 7.0 1.5 18.5 6.3 5.2 0.7 10.9 3.1 6.1 1.3 23.5 13.0 2.3 12.6 7.1 9.2 14.5 0.3 6.1 6.8 0.3 4.0 1.4 0.4 0.9 2.2 1.4 2.0 8.6 4.8 3.4 0.7 0.6 3.4 3.2 8.4 1.2 1.1 113.8 4.1 13.6 19.4 0.4 1.1 0.3 11.8 0.2 5.2 2.7 0.2 14.6 0.8 7.2 0.4 0.4 1.7 7.2 26.9 5.6 4.6 0.0 2.7 20.2 3.7 6.4 0.2 6.5 10.4 4.8 13.2 4.9 0.0 0.9 3.4 3.3 0.3 5.6 8.1 18.1 4.0 50.3 16.8 11.3 8.2 8.8 0.1 19.5 4.9 75.1 3.8 7.1 3.9 12.1 3.3 4.8 9.3 14.7 3.8 2.6 29.8 3.1 8.7 2.8 1.1 3.4 14.9 16.7 4.5 35.6 29.6 0.6 3.7 0.1 0.0 0.7 1.3 14.5 12.5 3.2 25.2 130.6 68.0 22.9 8.6 26.3 13.1 167.4 3.4 1.7 17.1 12.8 36.6 1.8 392.0 0.2 22.1 36.7 0.0 9.0 20.4 3.6 4.0 13.7 16.1 7.6 416.9 22.0 0.9 30.4 2.0 2.0 23.4 2.0 15.0 13.7 16.0 45.4 233.6 27.4 10.2 50.1 61.2 9.2 23.6 36.2 3.6 168.6 34.8 24.2 30.9 111.6 7.2 10.5 42.8 60.9 23.9 4.9 2.0 1.2 27.5 214.2 26.3 7.2 10.2 4.8 11.0 24.6 41.2 0.3 21.6 8.7 33.2 20.9 CAMK1G "CLICKIII, dJ272L16.1, VWS1" ENSG00000008118 "Calcium/calmodulin dependent protein kinase IG" Q96NX5 1 209583714-209613939 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Allosteric enzyme, Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "brain: 40.5;kidney: 11.1;ovary: 21.5" "Group enriched" "Detected in some" 6 "Excitatory neurons: 20.0;Inhibitory neurons: 15.5;Peritubular cells: 6.8;Sertoli cells: 6.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "hTEC/SVTERT24-B: 6.7;hTERT-RPE1: 4.1;SK-MEL-30: 2.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "unprognostic (5.17e-2)" "unprognostic (9.64e-2)" "unprognostic (1.73e-1)" "unprognostic (1.49e-3)" "unprognostic (2.56e-2)" "unprognostic (1.93e-1)" "unprognostic (6.79e-2)" "unprognostic (3.98e-1)" "unprognostic (3.59e-3)" "unprognostic (8.55e-3)" "unprognostic (3.17e-2)" "unprognostic (1.14e-2)" "unprognostic (4.25e-2)" "unprognostic (1.75e-1)" "unprognostic (2.27e-1)" "unprognostic (9.10e-2)" "unprognostic (3.43e-2)" 0.2 2.3 22.6 0.3 27.2 0.4 0.1 0.7 40.5 0.4 0.6 0.5 0.2 1.0 4.3 0.0 0.5 0.7 0.3 23.0 17.3 11.1 0.3 0.7 0.2 6.6 6.1 21.5 0.6 0.0 3.9 1.8 13.8 3.6 0.1 0.5 0.0 5.3 0.3 0.3 0.2 1.3 3.5 5.6 0.1 0.8 26.3 0.1 0.1 0.1 0.2 0.4 0.6 21.1 0.0 0.0 0.2 0.0 0.1 0.0 0.0 1.1 0.2 0.4 0.1 0.0 0.1 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.7 0.4 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 6.7 0.0 4.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.9 0.0 0.0 0.1 1.2 0.1 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 22.6 27.2 0.7 40.5 23.0 17.3 6.6 6.1 13.8 3.5 26.3 21.1 0.0 0.0 0.0 0.3 0.2 0.1 0.5 0.0 0.0 0.5 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.4 0.1 0.0 0.0 20.0 0.2 0.0 0.4 0.0 0.7 0.0 0.0 0.0 0.0 0.7 0.0 15.5 0.0 0.0 0.0 0.3 0.1 1.2 0.5 0.0 1.9 0.0 0.3 0.0 0.0 1.2 0.1 0.0 6.8 0.0 0.0 0.0 0.2 0.0 0.1 6.6 0.2 0.7 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.2 CAMK2A "CAMKA, CaMKIIα, CaMKIINalpha, KIAA0968" ENSG00000070808 "Calcium/calmodulin dependent protein kinase II alpha" Q9UQM7 5 150219491-150290291 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 7 "brain: 662.9" "Cell type enriched" "Detected in some" 4 "Excitatory neurons: 245.8" "Cancer enriched" "Detected in single" 13 "glioma: 6.0" "Region enhanced" "Detected in many" "cerebral cortex: 662.9" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HaCaT: 1.3;SCLC-21H: 3.0;SuSa: 1.4;U-87 MG: 3.9" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "cerebral cortex: 1071.1" "CAB004330, HPA051783, HPA051785, HPA053973" Supported Approved "Plasma membrane,Cell Junctions,Cytosol" NA NA 66000 "Cluster 10: Brain - Neuronal signaling" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane" "Cell Junctions, Cytosol" "CAB004330: AB_626788, HPA051783: AB_2681608, HPA051785: AB_2681609, HPA053973: AB_2682328" "unprognostic (7.20e-3)" "unprognostic (6.47e-3)" "unprognostic (6.16e-3)" "unprognostic (4.85e-2)" "unprognostic (4.25e-2)" "unprognostic (1.06e-3)" "unprognostic (1.13e-1)" "unprognostic (6.19e-3)" "unprognostic (3.07e-1)" "unprognostic (1.05e-1)" "unprognostic (4.49e-2)" "unprognostic (1.41e-2)" "unprognostic (2.00e-8)" "unprognostic (2.71e-4)" "unprognostic (1.68e-1)" "unprognostic (1.70e-2)" "unprognostic (1.36e-3)" 0.2 0.9 161.7 0.2 230.9 0.1 0.1 0.0 662.9 1.2 0.0 1.0 0.1 2.8 0.3 1.3 1.5 0.3 4.8 453.1 0.0 0.7 0.2 0.9 0.0 0.0 0.0 0.4 0.1 0.0 3.5 0.3 0.0 0.8 0.2 1.9 0.7 0.4 95.0 0.7 0.4 2.4 0.0 0.3 0.5 0.1 0.0 0.0 0.1 34.7 0.0 2.0 0.7 99.6 0.0 0.1 0.2 0.0 0.0 0.1 0.0 0.1 0.8 0.5 0.3 0.0 0.0 0.0 0.0 0.4 0.0 1.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.2 0.1 0.9 0.0 0.7 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 3.0 0.0 0.1 0.0 0.1 1.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 3.9 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 161.7 230.9 0.0 662.9 453.1 0.0 0.0 0.0 0.0 0.0 0.0 99.6 0.0 0.0 0.0 12.1 0.0 3.4 0.0 0.0 0.0 5.1 0.0 0.0 14.9 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.1 0.2 0.2 0.0 0.0 245.8 0.0 0.1 2.2 0.0 0.2 0.0 0.0 0.0 0.0 2.1 0.0 55.5 0.0 0.0 0.0 0.8 0.3 0.0 0.0 3.6 9.4 0.0 0.4 0.0 8.5 8.1 0.0 0.0 0.4 0.0 0.0 0.0 1.0 0.0 0.1 0.0 3.6 1.8 0.0 0.3 0.0 1.4 0.3 0.2 0.0 0.0 0.0 CAMK2B "CAM2, CAMK2, CAMKB, CaMKIIβ" ENSG00000058404 "Calcium/calmodulin dependent protein kinase II beta" Q13554 7 44217150-44334577 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Differentiation, Neurogenesis" "Actin-binding, Calmodulin-binding, Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 248.8;skeletal muscle: 132.5" "Cell type enriched" "Detected in many" 7 "Bipolar cells: 857.4" "Cancer enhanced" "Detected in many" "glioma: 6.0;thyroid cancer: 6.1" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enriched" "Detected in some" 7 "SCLC-21H: 75.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB006849, HPA026307, HPA051783, HPA051785, HPA053973" Enhanced Supported Supported "Plasma membrane,Cell Junctions,Cytosol" NA NA 600000 "Cluster 11: Basophils - Unknown function" "Cluster 47: Non-specific - Unknown function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 56: Bipolar cells - Visual perception" "Plasma membrane" "Cell Junctions, Cytosol" "CAB006849: , HPA026307: AB_1845941, HPA051783: AB_2681608, HPA051785: AB_2681609, HPA053973: AB_2682328" "unprognostic (1.88e-3)" "unprognostic (4.49e-2)" "unprognostic (3.55e-3)" "unprognostic (1.36e-2)" "unprognostic (5.25e-2)" "unprognostic (2.90e-2)" "unprognostic (8.78e-2)" "unprognostic (1.09e-1)" "unprognostic (1.44e-1)" "unprognostic (2.71e-1)" "unprognostic (1.17e-2)" "unprognostic (1.60e-2)" "unprognostic (5.23e-7)" "unprognostic (7.04e-2)" "unprognostic (2.34e-1)" "unprognostic (3.15e-2)" "unprognostic (3.95e-2)" 0.5 11.3 77.9 0.6 109.0 0.1 1.4 113.0 248.8 0.1 0.0 1.0 1.0 0.2 28.3 1.4 1.1 0.2 65.4 197.6 12.6 1.6 7.7 0.3 1.3 4.4 11.9 0.3 3.8 6.1 51.3 0.1 4.6 3.2 0.4 21.4 1.4 1.6 132.5 1.2 0.9 0.1 3.2 0.3 2.3 2.1 25.9 0.8 20.3 59.2 1.6 0.0 0.3 80.4 0.0 0.8 0.4 0.6 0.0 0.4 0.4 0.3 0.1 0.3 0.0 0.3 0.1 0.2 1.6 0.4 0.1 0.3 0.4 1.4 0.1 2.0 4.5 0.1 0.2 0.2 0.1 0.0 0.9 0.1 0.0 0.0 0.5 0.2 0.0 0.0 0.0 0.8 0.1 10.1 0.0 0.4 0.2 0.1 4.4 0.2 1.7 0.3 0.0 0.0 75.5 4.0 0.4 0.0 0.0 0.1 3.5 0.3 0.4 0.5 0.7 0.4 0.1 0.9 0.8 0.2 0.2 0.0 0.5 1.0 0.1 0.2 0.1 0.2 0.2 0.2 0.2 0.1 0.1 0.3 0.2 0.2 0.4 0.7 0.3 0.2 0.2 0.2 77.9 109.0 113.0 248.8 197.6 12.6 4.4 11.9 4.6 3.2 25.9 80.4 0.1 0.0 0.0 67.3 0.2 1.1 21.5 0.0 10.8 857.4 3.1 17.5 88.9 2.8 0.0 0.0 45.9 0.1 0.0 0.5 9.8 0.0 0.9 2.3 0.4 1.6 40.7 0.0 111.4 0.0 0.2 2.9 4.1 5.6 4.5 15.4 0.0 4.3 0.2 60.6 90.9 1.5 2.0 0.6 0.4 2.9 1.8 0.5 1.8 5.6 0.0 23.2 0.0 19.6 5.4 0.1 1.2 0.0 0.1 3.3 0.1 1.9 0.0 53.1 0.0 6.9 1.7 0.2 7.8 0.9 0.4 0.3 0.2 0.2 0.3 6.6 CAMK2D CAMKD ENSG00000145349 "Calcium/calmodulin dependent protein kinase II delta" Q13557 4 113451032-113761927 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 159.3" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 272.9;Excitatory neurons: 182.9;Inhibitory neurons: 200.0;Microglial cells: 187.4;Oligodendrocyte precursor cells: 203.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "ASC TERT1: 272.6" "Low region specificity" "Detected in all" "HPA026281, HPA051783, HPA051785, HPA053973" Approved Approved "Plasma membrane,Cell Junctions,Cytosol" NA NA 240000 "Cluster 21: B-cells - Adaptive immune response" "Cluster 38: Heart - Muscle contraction" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Plasma membrane" "Cell Junctions, Cytosol" "HPA026281: AB_1845944, HPA051783: AB_2681608, HPA051785: AB_2681609, HPA053973: AB_2682328" "unprognostic (2.14e-2)" "unprognostic (3.17e-1)" "unprognostic (2.13e-1)" "unprognostic (7.49e-2)" "unprognostic (2.19e-1)" "unprognostic (5.09e-1)" "unprognostic (4.26e-2)" "unprognostic (1.17e-1)" "unprognostic (2.26e-1)" "unprognostic (2.62e-1)" "unprognostic (7.81e-2)" "unprognostic (7.91e-3)" "unprognostic (2.62e-2)" "unprognostic (1.46e-1)" "unprognostic (9.68e-2)" "unprognostic (1.87e-1)" "unprognostic (1.90e-2)" 28.6 25.6 52.7 26.6 45.1 5.7 21.0 45.8 52.0 18.9 1.6 36.4 28.8 23.5 9.8 29.7 18.8 30.7 159.3 60.2 23.9 19.3 37.3 22.9 35.2 11.8 33.9 25.4 15.2 56.5 9.1 19.8 12.6 32.2 39.1 79.2 13.4 41.7 105.1 15.8 34.1 24.9 21.0 18.4 37.1 19.8 46.7 16.3 23.7 60.0 31.4 27.4 19.7 22.9 4.8 62.5 67.5 22.8 144.0 272.6 24.0 145.4 96.3 56.0 48.0 42.3 17.6 91.2 20.7 102.3 70.7 2.1 42.6 22.8 56.6 35.1 10.8 0.0 22.0 49.2 73.0 0.1 0.2 176.3 30.5 43.5 107.1 88.5 50.6 11.3 3.6 39.4 106.8 17.1 9.3 3.6 9.8 60.3 22.8 17.9 79.0 0.4 57.3 42.7 18.2 18.3 20.0 29.3 19.5 55.9 0.6 23.7 30.7 146.9 34.8 63.6 29.1 30.4 16.5 76.7 75.7 5.5 70.8 0.0 12.7 0.0 6.7 7.0 12.7 11.2 6.6 7.5 15.7 22.6 7.4 6.5 0.9 9.7 2.5 0.1 13.2 7.7 52.7 45.1 45.8 52.0 60.2 23.9 11.8 33.9 12.6 21.0 46.7 22.9 43.7 41.7 37.6 128.3 55.1 18.4 16.6 8.3 22.8 83.3 14.0 17.1 272.9 62.9 24.7 29.5 87.6 0.5 19.0 70.9 5.9 8.4 3.2 18.2 35.2 27.2 103.8 3.6 182.9 20.1 0.4 50.1 71.9 47.0 10.1 13.0 24.3 57.2 18.6 72.3 200.0 88.1 14.2 17.3 22.3 6.2 20.2 31.5 5.4 187.4 16.0 35.9 28.8 203.1 128.0 11.6 57.3 19.9 20.4 36.2 52.4 23.1 21.7 74.0 6.6 32.8 44.4 3.1 3.4 37.1 31.8 1.1 27.8 12.3 48.6 27.5 CAMK2G CAMKG ENSG00000148660 "Calcium/calmodulin dependent protein kinase II gamma" Q13555 10 73812501-73874591 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Differentiation, Neurogenesis" "Calmodulin-binding, Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 154.3" "Cell type enhanced" "Detected in many" "Astrocytes: 410.7;Cytotrophoblasts: 163.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "eosinophil: 133.9" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "PC-3: 154.8;SK-BR-3: 177.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040656, HPA051783, HPA051785, HPA053973" Approved Approved "Plasma membrane,Cell Junctions,Cytosol" NA NA 200000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 80: Striated muscle - Unknown function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 47: Cytotrophoblasts - Unknown function" "Plasma membrane" "Cell Junctions, Cytosol" "HPA040656: AB_2677065, HPA051783: AB_2681608, HPA051785: AB_2681609, HPA053973: AB_2682328" "unprognostic (8.63e-3)" "unprognostic (2.01e-1)" "unprognostic (1.05e-1)" "unprognostic (3.46e-3)" "unprognostic (4.27e-2)" "unprognostic (1.82e-2)" "unprognostic (2.19e-2)" "unprognostic (2.36e-1)" "unprognostic (2.48e-1)" "unprognostic (6.25e-2)" "unprognostic (2.92e-2)" "unprognostic (1.08e-1)" "unprognostic (1.73e-2)" "unprognostic (2.48e-1)" "unprognostic (8.28e-2)" "unprognostic (9.64e-2)" "unprognostic (4.62e-2)" 22.0 14.0 86.1 17.0 92.6 34.5 15.2 79.9 137.8 24.1 44.1 101.1 34.2 45.2 14.5 34.7 30.6 17.8 11.8 91.3 79.0 19.3 14.5 18.8 16.2 96.1 96.5 12.7 10.3 12.3 14.1 27.3 94.1 31.1 26.1 42.4 22.9 49.6 154.3 17.3 41.5 43.9 91.4 24.9 30.4 6.5 102.5 15.7 13.6 84.8 14.9 58.4 25.8 91.9 35.7 24.6 22.5 43.9 16.7 26.1 26.3 25.8 41.0 31.9 26.1 39.8 37.2 27.4 25.7 32.4 12.4 54.9 17.5 20.5 25.3 24.0 22.2 18.2 20.4 17.8 8.1 24.7 29.1 14.4 17.7 32.5 22.1 50.4 28.3 32.5 19.5 37.9 19.0 25.2 41.7 37.5 16.5 21.3 154.8 36.5 25.3 13.7 17.2 51.5 11.5 28.4 15.0 177.4 11.9 16.5 33.2 15.0 36.7 24.9 40.0 13.4 33.3 11.9 14.9 24.8 26.5 69.2 8.8 31.0 17.9 133.9 23.1 7.9 28.5 13.9 26.3 25.0 23.0 12.7 24.5 24.1 115.8 34.0 15.1 7.9 27.7 17.5 86.1 92.6 79.9 137.8 91.3 79.0 96.1 96.5 94.1 91.4 102.5 91.9 19.3 16.0 11.7 410.7 22.2 9.4 8.7 9.2 14.2 63.3 14.8 16.3 6.7 12.8 15.5 7.3 100.1 163.6 21.3 46.2 13.7 13.3 2.0 6.3 6.4 20.2 23.9 13.3 107.9 19.6 45.2 12.0 14.8 7.5 16.5 20.2 16.4 9.6 27.2 26.9 89.7 24.8 10.2 18.9 16.3 3.1 12.8 15.8 12.4 43.1 18.3 17.7 26.8 61.9 16.9 22.0 65.5 18.8 13.6 8.2 77.1 26.9 10.4 77.0 46.0 11.2 50.8 0.8 13.5 26.5 12.6 81.1 30.3 5.2 32.1 13.7 CAMK4 "CaMK-GR, CaMKIV" ENSG00000152495 "Calcium/calmodulin dependent protein kinase IV" Q16566 5 111223653-111494886 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Adaptive immunity, Immunity, Inflammatory response" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 7 "brain: 70.4;lymphoid tissue: 55.4" "Cell type enhanced" "Detected in many" "Bipolar cells: 70.9;Early spermatids: 306.2;Excitatory neurons: 212.2;Inhibitory neurons: 131.8;Late spermatids: 108.4;Oligodendrocyte precursor cells: 133.2;T-cells: 83.3" "Low cancer specificity" "Detected in some" "Group enriched" "Detected in many" 6 "basal ganglia: 30.6;cerebellum: 70.4" "Group enriched" "Detected in many" 4 "MAIT T-cell: 24.3;memory CD4 T-cell: 17.3;memory CD8 T-cell: 13.5;naive CD4 T-cell: 33.1;naive CD8 T-cell: 18.5;T-reg: 21.3" "Lineage enriched" "Detected in many" 23 "T-cells: 33.1" "Cell line enhanced" "Detected in many" "HDLM-2: 88.9;JURKAT: 61.3;MOLT-4: 27.9;SH-SY5Y: 33.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004347, HPA011753, HPA017206" Approved Supported "Nucleoplasm,Nucleoli fibrillar center" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 58: T-cells - T-cell receptor" "Nucleoplasm, Nucleoli fibrillar center" "CAB004347: AB_626793, HPA011753: AB_1845950, HPA017206: AB_1845949" "unprognostic (2.99e-5)" "unprognostic (7.19e-2)" "unprognostic (3.43e-3)" "unprognostic (5.11e-2)" "unprognostic (4.75e-3)" "unprognostic (3.48e-2)" "unprognostic (7.66e-4)" "unprognostic (7.22e-3)" "unprognostic (2.49e-1)" "unprognostic (2.92e-1)" "unprognostic (1.09e-1)" "unprognostic (1.46e-1)" "unprognostic (2.23e-5)" "unprognostic (2.42e-2)" "unprognostic (3.01e-2)" "unprognostic (1.66e-1)" "unprognostic (9.99e-3)" 0.4 3.8 5.0 4.4 30.6 3.1 0.4 70.4 8.2 0.9 0.0 1.3 1.4 0.6 0.3 0.7 0.3 1.5 0.1 7.6 0.0 0.7 1.4 1.1 8.1 0.0 0.4 0.6 0.4 0.0 0.6 0.2 1.4 3.4 1.4 4.7 0.4 1.4 0.1 0.1 2.3 0.8 0.0 2.6 1.5 9.4 0.8 55.4 0.2 0.0 5.2 1.7 0.4 0.0 0.0 0.0 3.1 2.1 0.6 2.3 0.0 0.8 6.8 8.0 7.8 0.0 0.1 0.0 4.0 0.4 5.4 0.3 6.8 0.8 5.8 88.9 5.2 1.3 2.8 0.0 0.2 0.6 0.3 0.3 0.0 16.8 1.7 4.9 1.4 61.3 0.0 3.3 0.4 0.0 27.9 0.0 4.1 0.0 0.2 4.0 5.0 0.2 2.9 0.1 18.8 33.5 1.2 0.0 5.6 0.2 0.1 0.5 0.1 16.3 9.5 0.1 14.7 2.6 0.3 0.0 8.0 0.0 6.3 0.1 0.0 0.0 4.8 0.0 24.3 1.3 17.3 13.5 0.0 0.3 33.1 18.5 0.9 1.4 0.0 0.1 21.3 5.5 5.0 30.6 70.4 8.2 7.6 0.0 0.0 0.4 1.4 0.0 0.8 0.0 1.8 0.0 1.1 57.8 9.4 1.1 0.3 1.3 8.6 70.9 0.6 0.6 5.3 0.0 0.0 0.0 0.0 0.1 3.1 0.1 0.0 0.1 306.2 0.2 1.6 1.1 0.0 0.0 212.2 0.0 0.2 4.6 3.6 0.4 4.5 0.3 0.7 0.3 0.2 0.0 131.8 0.8 0.0 1.3 2.1 108.4 4.1 2.0 0.0 12.2 2.7 2.8 1.0 133.2 5.4 1.2 0.0 1.5 11.5 0.5 0.0 0.1 0.1 4.3 0.0 0.6 3.8 30.3 6.2 2.4 1.0 0.0 83.3 0.1 0.0 0.3 CAMKK1 "CAMKKA, DKFZp761M0423, MGC34095" ENSG00000004660 "Calcium/calmodulin dependent protein kinase kinase 1" Q8N5S9 17 3860315-3894891 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 54.4" "Cell type enhanced" "Detected in many" "Bipolar cells: 41.9;Excitatory neurons: 52.7;Rod photoreceptor cells: 25.1" "Low cancer specificity" "Detected in many" "Group enriched" "Detected in many" 5 "amygdala: 21.5;basal ganglia: 24.2;cerebral cortex: 54.4;hippocampal formation: 24.8;white matter: 31.9" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HeLa: 28.3;U-87 MG: 27.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009111, HPA028062" Approved Supported Cytosol No No "Cluster 45: Eosinophils - Innate immune response" "Cluster 10: Brain - Neuronal signaling" "Cluster 20: HeLa - Mitochondria" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "CAB009111: AB_2068406, HPA028062: AB_1845954" "unprognostic (1.39e-2)" "unprognostic (2.13e-1)" "unprognostic (8.66e-3)" "unprognostic (4.40e-3)" "unprognostic (2.94e-3)" "unprognostic (4.79e-2)" "unprognostic (1.98e-1)" "unprognostic (4.47e-3)" "unprognostic (8.23e-2)" "unprognostic (1.03e-2)" "prognostic favorable (2.65e-4)" "unprognostic (1.98e-1)" "unprognostic (1.59e-1)" "unprognostic (7.19e-2)" "unprognostic (8.70e-2)" "unprognostic (8.36e-2)" "unprognostic (3.10e-1)" 6.0 10.7 21.5 5.2 24.2 4.1 5.4 5.6 54.4 12.7 0.0 10.2 2.9 13.1 4.8 6.8 7.0 3.6 5.7 24.8 0.8 3.6 1.0 5.0 2.6 6.0 1.9 8.1 12.7 4.1 24.4 2.0 6.6 8.2 2.7 12.0 29.9 10.4 3.4 15.9 6.9 5.8 0.6 9.6 4.2 10.1 5.0 5.1 7.6 1.6 2.3 16.1 13.8 31.9 7.0 11.8 1.2 5.9 4.1 7.2 0.4 4.7 5.1 4.4 2.0 4.3 2.1 4.2 5.0 9.1 4.6 20.3 3.2 5.8 2.7 0.1 10.7 4.8 28.3 1.6 4.2 0.7 3.6 5.5 4.9 8.4 2.8 3.8 2.0 6.0 3.8 0.2 2.2 1.9 6.0 2.7 1.3 10.1 11.0 3.0 5.1 4.8 4.8 4.4 6.7 3.8 1.8 13.9 3.1 0.7 5.3 1.6 2.8 7.6 10.2 9.9 4.0 0.5 0.3 0.1 27.9 4.0 1.0 0.0 0.9 1.9 0.2 2.0 0.5 0.0 0.3 0.2 0.8 0.0 0.3 0.1 2.7 0.0 2.1 0.4 0.0 0.7 21.5 24.2 5.6 54.4 24.8 0.8 6.0 1.9 6.6 0.6 5.0 31.9 5.5 6.4 12.5 8.1 7.0 3.7 2.1 1.5 1.8 41.9 2.5 1.3 6.3 0.0 3.3 1.8 16.7 0.3 3.4 1.7 0.0 0.4 0.1 1.7 7.8 5.6 4.2 0.4 52.7 1.6 0.1 5.5 0.5 1.6 17.1 0.9 2.9 0.6 4.3 8.4 13.9 1.3 2.0 3.2 3.3 1.3 1.2 6.9 8.8 9.4 0.8 4.7 2.1 4.0 3.5 0.6 0.6 1.2 2.2 2.2 0.2 0.3 1.5 25.1 0.0 2.0 1.7 0.1 1.1 4.1 5.4 0.3 2.9 1.2 2.1 1.1 CAMKK2 "CAMKK, CAMKKB, KIAA0787, MGC15254" ENSG00000110931 "Calcium/calmodulin dependent protein kinase kinase 2" Q96RR4 12 121237675-121298308 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 135.4" "Cell type enhanced" "Detected in many" "Excitatory neurons: 64.8;Horizontal cells: 62.2;Late spermatids: 89.6" "Cancer enriched" "Detected in all" 5 "prostate cancer: 56.3" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 4 "classical monocyte: 32.7;eosinophil: 62.1;intermediate monocyte: 42.3;myeloid DC: 15.9;neutrophil: 39.2;non-classical monocyte: 39.5" "Group enriched" "Detected in all" 5 "dendritic cells: 15.9;granulocytes: 62.1;monocytes: 42.3" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017389, HPA063713" Approved Supported Supported Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 29: U-266 - Adaptive immune response" "Cluster 31: Spermatids - Spermatogenesis" Cytosol "HPA017389: AB_1845956, HPA063713: " "unprognostic (5.08e-2)" "unprognostic (1.81e-1)" "unprognostic (1.38e-1)" "unprognostic (3.08e-1)" "unprognostic (1.88e-1)" "unprognostic (1.12e-1)" "unprognostic (2.62e-3)" "unprognostic (2.80e-2)" "unprognostic (1.93e-1)" "unprognostic (7.76e-2)" "unprognostic (5.01e-2)" "unprognostic (1.70e-1)" "unprognostic (1.75e-1)" "unprognostic (4.13e-1)" "unprognostic (3.34e-2)" "unprognostic (1.67e-1)" "unprognostic (1.38e-1)" 26.0 16.7 39.6 17.0 56.2 30.8 22.7 135.4 65.5 22.3 14.3 22.8 25.7 22.9 10.8 17.5 27.5 12.9 17.8 44.8 24.8 16.7 30.9 23.6 15.3 20.8 20.1 27.4 16.8 12.4 11.8 15.3 24.9 29.5 19.4 7.1 18.6 23.8 11.5 18.3 26.6 20.7 18.3 39.6 24.0 7.0 23.6 13.4 17.1 11.2 15.6 25.9 21.1 42.7 27.9 20.5 16.3 30.9 46.7 43.0 22.8 22.0 23.8 19.0 17.3 21.4 12.1 43.0 18.1 48.1 14.1 22.7 20.0 25.8 15.1 29.3 35.9 22.0 14.4 21.3 31.1 50.0 20.0 28.2 37.2 18.0 41.4 26.0 45.0 33.5 25.2 23.6 18.4 27.2 55.8 40.6 11.7 24.9 22.7 35.3 18.4 37.7 18.8 32.1 60.2 22.4 31.5 16.5 19.1 12.9 39.7 62.0 32.2 14.8 11.8 13.1 13.0 84.8 55.6 32.7 27.7 34.4 16.0 2.0 32.7 62.1 4.7 42.3 4.6 4.8 3.5 4.2 15.9 2.8 3.2 3.8 39.2 8.6 39.5 3.6 3.3 15.8 39.6 56.2 135.4 65.5 44.8 24.8 20.8 20.1 24.9 18.3 23.6 42.7 25.4 9.6 5.6 9.8 5.7 7.9 6.0 8.1 8.0 22.2 11.6 10.5 8.2 12.8 8.3 9.2 2.1 9.2 10.6 18.2 3.9 9.6 16.0 6.5 19.6 21.9 34.3 12.0 64.8 10.4 8.2 18.0 13.3 10.9 6.3 23.3 15.0 19.7 7.9 62.2 21.4 16.2 8.2 14.8 15.6 89.6 20.5 16.6 8.8 12.2 36.3 5.4 12.3 10.1 19.3 8.5 10.9 31.6 11.9 16.5 26.6 9.6 7.2 7.0 19.7 7.7 20.6 0.8 2.9 13.3 6.0 3.4 7.6 32.7 17.6 6.3 CAMKMT "C2orf34, CLNMT" ENSG00000143919 "Calmodulin-lysine N-methyltransferase" Q7Z624 2 44361947-44772592 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 155.1;Excitatory neurons: 88.7;Inhibitory neurons: 93.7;Microglial cells: 114.3;Oligodendrocyte precursor cells: 121.2;Oligodendrocytes: 211.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA067912 Supported Nucleoplasm NA NA "Cluster 6: Non-specific - Transcription" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "HPA067912: AB_2685922" "unprognostic (2.28e-1)" "unprognostic (6.15e-2)" "unprognostic (1.96e-1)" "unprognostic (2.39e-2)" "prognostic favorable (9.10e-4)" "unprognostic (1.03e-1)" "unprognostic (9.58e-3)" "unprognostic (1.46e-3)" "unprognostic (1.85e-1)" "unprognostic (7.42e-2)" "unprognostic (8.76e-2)" "unprognostic (1.37e-1)" "unprognostic (3.33e-1)" "unprognostic (4.82e-2)" "unprognostic (4.66e-2)" "unprognostic (1.70e-1)" "unprognostic (8.57e-2)" 4.2 5.3 15.9 3.9 21.1 10.2 5.3 19.4 21.1 5.9 17.8 7.0 5.3 4.1 6.5 6.1 4.9 5.7 5.0 15.5 17.1 7.5 4.8 3.9 5.4 17.7 16.4 3.9 9.8 9.8 5.6 3.3 17.3 3.5 6.8 8.5 4.8 3.9 7.8 5.8 5.7 3.9 15.5 3.7 5.8 13.2 17.9 6.2 7.3 3.3 5.4 4.5 4.7 20.4 10.2 6.2 7.4 6.8 8.0 8.1 15.0 7.4 6.0 4.3 5.5 11.9 9.0 9.6 8.6 5.6 5.3 8.3 10.6 13.2 7.6 35.2 13.3 14.2 12.1 22.4 3.1 9.4 9.5 2.6 8.0 5.9 10.9 6.1 6.4 9.9 10.4 17.1 7.1 10.9 17.6 19.1 13.9 24.6 6.1 10.3 8.3 19.4 20.8 11.6 14.0 13.4 7.6 24.1 9.2 7.0 8.8 7.7 7.6 5.5 6.4 6.1 5.9 13.3 11.5 18.2 6.1 16.5 3.9 13.1 8.2 6.2 11.1 6.9 11.5 20.9 11.2 9.7 9.7 14.7 16.9 13.4 5.2 8.7 8.4 10.1 18.3 6.9 15.9 21.1 19.4 21.1 15.5 17.1 17.7 16.4 17.3 15.5 17.9 20.4 5.4 6.4 3.1 155.1 11.0 5.2 7.9 10.9 9.1 5.3 6.6 5.2 2.2 10.0 5.5 9.2 0.0 3.3 6.9 4.5 23.5 13.3 74.3 8.2 7.2 4.0 0.0 13.3 88.7 15.6 4.5 6.2 11.7 10.0 5.7 2.0 3.3 6.3 5.8 1.7 93.7 5.5 20.3 1.9 4.9 39.0 8.1 4.3 10.6 114.3 6.4 20.3 13.4 121.2 211.7 8.6 8.3 5.7 13.3 5.8 7.2 14.5 7.4 3.0 0.0 3.6 5.0 35.5 5.8 10.7 7.4 2.6 9.2 7.9 8.1 6.0 CARM1 PRMT4 ENSG00000142453 "Coactivator associated arginine methyltransferase 1" Q86X55 19 10871553-10923075 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Host-virus interaction, Transcription, Transcription regulation" "Chromatin regulator, Methyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 110.5" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB032961, HPA043561, HPA048073, HPA069313" Supported Enhanced Nucleoplasm "Intracellular and membrane" NA NA 19000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 80: Striated muscle - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "CAB032961: AB_2068446, HPA043561: AB_2678554, HPA048073: AB_2680250, HPA069313: " "unprognostic (9.46e-2)" "unprognostic (3.61e-1)" "unprognostic (2.94e-2)" "unprognostic (2.23e-1)" "unprognostic (2.69e-2)" "unprognostic (3.13e-2)" "unprognostic (1.66e-3)" "unprognostic (3.76e-2)" "unprognostic (7.81e-2)" "unprognostic (6.18e-2)" "unprognostic (9.31e-2)" "unprognostic (7.25e-2)" "prognostic unfavorable (7.88e-6)" "unprognostic (1.71e-2)" "unprognostic (6.26e-2)" "unprognostic (1.00e-1)" "prognostic unfavorable (8.37e-4)" 20.3 17.1 24.7 19.6 26.6 22.7 17.6 18.9 34.1 30.6 17.2 28.4 17.3 31.7 7.8 36.7 23.4 14.7 25.4 27.6 23.7 18.8 20.1 16.4 19.8 22.8 21.8 21.9 22.3 11.5 14.8 20.4 22.6 20.2 14.3 6.4 20.2 17.5 110.5 22.6 20.9 21.3 19.9 18.6 20.3 45.4 22.6 10.9 13.4 72.4 15.4 26.3 28.0 26.0 62.5 46.8 64.9 88.3 52.5 71.1 63.2 42.8 75.6 63.9 61.0 73.4 21.8 85.2 52.4 77.4 32.1 58.0 65.4 66.2 40.1 98.4 52.7 26.5 29.1 89.9 44.8 39.3 33.9 49.0 42.4 43.8 52.4 35.9 82.1 67.9 65.8 79.2 38.2 116.7 70.0 34.3 81.4 40.7 74.8 97.5 32.8 100.7 38.9 29.7 47.0 45.1 30.7 36.2 43.6 31.7 38.4 35.3 48.7 75.4 43.2 72.3 54.0 75.0 64.1 77.2 51.1 63.8 35.3 0.0 0.2 0.0 0.1 0.2 0.1 0.2 0.1 0.5 0.2 0.2 0.1 0.1 0.0 0.0 0.1 0.3 0.1 0.1 24.7 26.6 18.9 34.1 27.6 23.7 22.8 21.8 22.6 19.9 22.6 26.0 12.9 9.6 12.2 7.2 11.6 7.8 5.9 4.1 12.0 36.4 14.0 13.7 1.1 14.3 6.5 9.2 52.1 18.5 6.4 42.3 7.9 13.4 32.7 20.1 30.8 12.7 27.6 30.7 12.9 19.7 33.1 13.8 13.7 25.4 1.3 17.8 12.8 27.8 26.7 45.4 10.6 24.9 4.1 20.0 10.9 23.5 28.3 14.8 5.4 5.6 23.9 8.7 4.1 10.6 5.8 24.8 27.2 19.2 11.7 14.1 22.6 9.2 7.4 21.1 6.6 19.6 13.0 23.8 17.5 25.7 7.0 12.0 6.5 6.6 25.7 11.8 CARNMT1 "C9orf41, FLJ25795" ENSG00000156017 "Carnosine N-methyltransferase 1" Q8N4J0 9 74980790-75028423 "Enzymes, Predicted intracellular proteins" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enriched" "Detected in many" 5 "Early spermatids: 256.8" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "cerebellum: 24.6" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA026756 Uncertain NA NA "Cluster 35: T-regs - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 32: U-937 - Innate immune response" "Cluster 23: Spermatids - Flagellum & Golgi organization" "HPA026756: AB_1845824" "unprognostic (1.59e-1)" "unprognostic (1.02e-1)" "unprognostic (2.99e-2)" "unprognostic (4.81e-2)" "unprognostic (3.48e-1)" "unprognostic (1.56e-1)" "unprognostic (3.22e-2)" "unprognostic (4.92e-2)" "unprognostic (3.94e-2)" "unprognostic (1.15e-1)" "unprognostic (2.42e-2)" "unprognostic (1.54e-1)" "unprognostic (1.25e-2)" "unprognostic (1.45e-2)" "unprognostic (3.00e-1)" "unprognostic (1.85e-1)" "unprognostic (4.62e-2)" 5.1 6.1 1.8 7.0 13.8 8.3 7.0 24.6 6.0 5.8 0.1 9.2 12.7 6.1 8.3 10.0 6.2 6.8 5.4 3.7 0.4 12.2 17.1 5.4 9.7 0.1 2.5 6.1 9.0 11.3 3.9 5.3 1.8 6.4 8.5 7.8 9.1 5.3 8.7 8.4 12.4 6.1 0.2 6.7 7.8 16.4 1.0 8.4 13.6 8.5 8.5 9.1 5.1 3.5 27.6 16.1 6.6 17.0 10.3 22.4 24.6 24.4 10.0 9.0 8.2 4.1 17.9 43.7 12.9 17.4 19.2 26.7 20.0 25.3 25.5 40.0 17.4 22.3 15.5 18.4 12.6 40.7 21.2 15.0 12.4 17.0 17.3 13.3 18.6 15.6 19.1 36.9 17.4 7.3 29.8 10.8 31.4 33.0 14.7 14.4 20.2 25.4 23.5 19.0 6.5 3.6 18.7 46.2 9.2 11.8 23.5 11.7 14.8 14.8 19.9 18.2 21.3 28.2 38.3 13.1 22.9 27.6 9.8 0.0 0.4 1.0 1.3 0.8 1.9 1.7 1.3 2.0 0.6 0.9 1.6 1.5 0.1 1.5 0.4 0.6 2.0 0.7 1.8 13.8 24.6 6.0 3.7 0.4 0.1 2.5 1.8 0.2 1.0 3.5 8.5 6.4 11.7 0.0 10.2 0.0 11.6 0.0 21.6 14.5 16.6 8.0 0.0 11.5 6.8 27.6 10.4 7.0 18.6 4.5 25.4 7.5 256.8 11.2 19.6 9.4 7.3 6.3 0.0 11.9 13.0 6.6 13.7 14.8 2.5 8.7 8.9 29.8 8.1 20.2 0.0 12.8 0.0 9.1 0.0 44.3 7.5 8.5 0.0 0.0 8.9 5.6 17.5 0.0 0.0 9.3 8.8 10.9 17.4 17.7 22.6 37.3 4.4 10.4 0.0 9.3 5.6 17.7 10.3 33.5 0.0 5.1 17.1 16.2 13.2 15.0 CASD1 "C7orf12, FLJ21213, FLJ21879" ENSG00000127995 "CAS1 domain containing 1" Q96PB1 7 94509219-94557019 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 93.7;Inhibitory neurons: 108.5;Oligodendrocyte precursor cells: 122.6;Oligodendrocytes: 170.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044404 Uncertain Approved Nucleoplasm Yes No "Cluster 16: MAIT-cells - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "HPA044404: AB_10964353" "unprognostic (4.02e-2)" "unprognostic (4.16e-2)" "unprognostic (1.43e-1)" "unprognostic (1.82e-1)" "unprognostic (7.04e-2)" "unprognostic (7.90e-2)" "unprognostic (3.66e-2)" "unprognostic (2.18e-2)" "unprognostic (9.83e-2)" "unprognostic (4.74e-2)" "unprognostic (4.95e-3)" "unprognostic (2.16e-2)" "unprognostic (5.24e-2)" "unprognostic (4.01e-3)" "unprognostic (1.93e-1)" "unprognostic (7.07e-2)" "unprognostic (2.59e-3)" 11.1 25.3 11.4 9.6 14.0 6.0 15.7 11.1 12.9 11.3 4.8 16.5 6.5 14.1 14.6 6.3 11.0 10.0 17.1 14.9 17.4 12.4 9.0 11.3 12.5 8.8 10.7 16.4 9.8 13.8 8.7 12.3 12.9 13.9 19.3 22.1 20.3 9.4 14.1 3.8 6.1 11.0 11.3 10.6 7.3 13.1 14.6 11.2 16.0 19.6 10.8 9.1 4.3 14.0 5.5 10.4 34.7 12.9 10.4 12.3 5.9 7.2 12.8 7.9 10.2 6.5 13.2 13.9 18.5 9.8 14.1 3.0 8.8 2.5 15.4 22.2 7.1 12.3 8.5 11.9 8.8 20.5 0.0 11.4 9.2 7.2 10.3 15.4 12.6 16.0 6.7 29.3 19.6 8.0 28.5 11.6 17.7 7.7 8.2 19.3 28.0 10.8 15.9 14.9 13.1 44.5 11.4 20.7 7.4 24.9 5.4 12.8 6.7 19.6 15.5 16.2 10.6 28.0 28.1 28.5 10.7 4.7 12.9 0.0 0.2 0.0 0.6 0.2 1.6 0.6 0.9 0.8 0.4 0.5 0.9 0.7 0.0 0.6 0.2 0.3 0.6 0.2 11.4 14.0 11.1 12.9 14.9 17.4 8.8 10.7 12.9 11.3 14.6 14.0 26.2 28.9 26.3 76.0 15.4 4.6 5.8 5.8 4.0 56.4 14.4 12.8 21.1 17.2 12.8 20.2 18.8 14.2 14.6 29.7 3.9 5.1 3.4 18.0 13.1 16.4 7.2 4.6 93.7 5.6 5.7 14.6 5.1 9.9 10.2 23.7 16.1 13.3 8.8 67.3 108.5 30.2 2.0 9.8 5.5 7.0 11.5 10.8 24.9 61.8 7.1 23.3 10.3 122.6 170.3 6.8 11.8 9.8 9.2 10.0 0.6 10.8 18.1 31.4 19.7 41.2 12.2 9.6 12.8 4.7 4.5 16.8 12.2 25.8 19.5 4.5 CASK "CAGH39, FGS4, LIN2, TNRC8" ENSG00000147044 "Calcium/calmodulin dependent serine protein kinase" O14936 X 41514934-41923554 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Inhibitory neurons: 135.8;Oligodendrocyte precursor cells: 447.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 5 "basophil: 47.1" "Lineage enriched" "Detected in many" 10 "granulocytes: 47.1" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB001949, HPA023857" Enhanced Approved Nucleoplasm,Cytosol NA NA "Cluster 46: Basophils - DNA binding" "Cluster 9: Intestine - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 68: Oligodendrocytes - Mixed function" Nucleoplasm Cytosol "CAB001949: , HPA023857: AB_1846035" "unprognostic (6.30e-2)" "unprognostic (3.78e-2)" "unprognostic (1.48e-1)" "unprognostic (2.48e-3)" "unprognostic (1.56e-1)" "unprognostic (1.29e-1)" "unprognostic (1.42e-3)" "unprognostic (3.58e-1)" "unprognostic (1.02e-1)" "unprognostic (5.85e-3)" "prognostic unfavorable (6.11e-5)" "unprognostic (1.13e-1)" "unprognostic (1.05e-1)" "unprognostic (8.72e-2)" "unprognostic (1.15e-2)" "unprognostic (2.13e-2)" "unprognostic (2.85e-2)" 10.2 11.1 13.6 11.9 12.9 7.3 15.7 12.3 11.1 11.6 12.4 25.3 32.1 11.1 9.4 13.7 10.5 18.5 6.8 14.2 17.1 16.4 13.4 12.2 12.5 13.2 19.4 13.5 12.8 11.8 6.3 16.3 15.7 10.6 27.3 19.8 13.2 8.3 5.0 9.3 31.9 12.0 15.4 12.4 19.8 3.6 25.2 15.4 10.6 6.1 10.4 15.3 8.8 18.0 27.4 32.5 31.4 19.1 21.6 18.6 10.9 23.2 18.7 13.2 12.3 72.3 42.6 0.4 12.0 29.3 23.8 52.3 35.2 23.2 22.8 25.4 20.9 0.6 27.7 26.2 22.1 4.4 3.6 19.8 63.2 25.1 30.1 27.5 11.6 15.3 2.2 21.3 30.2 30.9 8.4 2.2 29.7 37.6 22.6 12.7 79.8 13.2 31.2 54.8 29.7 15.6 43.7 17.7 13.9 52.7 19.0 0.8 14.2 24.4 25.8 22.1 13.3 7.6 5.2 9.5 24.4 3.1 16.9 47.1 1.5 8.7 0.8 1.1 0.8 0.7 0.9 1.3 0.4 0.9 1.2 1.1 1.7 4.3 0.7 0.5 4.5 0.6 13.6 12.9 12.3 11.1 14.2 17.1 13.2 19.4 15.7 15.4 25.2 18.0 13.0 12.8 20.4 101.9 8.8 32.6 42.7 11.1 8.0 42.2 23.7 16.5 7.8 8.6 14.6 7.3 22.9 2.0 12.1 25.8 50.9 13.7 0.9 9.6 24.1 16.0 13.8 0.8 96.6 14.5 0.7 18.8 18.8 11.9 0.0 17.4 8.9 15.0 21.3 50.5 135.8 28.7 14.2 2.8 21.5 1.0 9.9 10.7 10.6 60.0 2.5 9.3 0.0 447.8 59.7 22.1 24.1 9.4 7.0 16.4 35.2 20.9 15.7 25.7 19.7 38.2 20.6 2.9 2.1 13.9 32.5 1.6 26.5 47.7 41.8 33.2 CBL "c-Cbl, CBL2, RNF55" ENSG00000110395 "Cbl proto-oncogene" P22681 11 119206298-119313926 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 8.6" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004350, HPA027956" Enhanced Approved Cytosol NA NA 67000 "Cluster 1: Neutrophils - Mixed function" "Cluster 3: T-cells - Adaptive immune response" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Cytosol "CAB004350: AB_2244054, HPA027956: AB_10601094" "unprognostic (2.52e-1)" "unprognostic (1.32e-3)" "unprognostic (1.60e-1)" "unprognostic (1.15e-1)" "unprognostic (1.50e-2)" "unprognostic (2.92e-1)" "unprognostic (4.10e-3)" "unprognostic (9.75e-2)" "unprognostic (1.72e-1)" "unprognostic (1.52e-1)" "unprognostic (1.03e-2)" "unprognostic (5.23e-2)" "unprognostic (5.21e-2)" "unprognostic (5.27e-2)" "unprognostic (1.52e-1)" "unprognostic (1.12e-1)" "unprognostic (5.85e-2)" 6.8 4.0 5.6 9.5 5.7 8.5 5.6 5.3 6.5 5.0 0.2 6.2 3.9 6.5 3.4 5.6 5.6 3.9 4.1 5.3 8.1 4.4 2.7 7.9 10.7 5.8 6.3 3.7 3.8 6.1 2.9 6.4 6.5 4.0 5.0 8.3 3.6 4.6 2.5 5.2 6.6 7.4 5.2 9.9 5.2 18.2 7.9 22.5 4.1 3.2 11.2 5.8 4.9 6.0 10.7 7.6 26.6 16.7 7.8 9.2 16.0 11.2 11.4 10.8 10.2 16.7 12.6 25.1 10.0 14.0 21.7 15.2 18.4 9.4 22.7 14.8 4.7 26.4 6.2 5.1 9.5 30.3 27.9 8.1 10.1 26.7 28.4 11.1 26.3 23.7 21.7 9.9 19.1 11.3 16.2 17.0 14.0 9.2 8.8 17.5 13.5 4.6 9.3 8.2 3.7 11.3 20.9 8.8 7.3 18.1 9.4 24.8 22.8 16.0 11.5 11.6 14.7 3.3 5.3 19.9 6.7 25.4 11.9 0.8 2.4 2.0 0.9 2.8 0.8 1.5 1.1 0.9 2.6 1.2 1.2 1.3 8.6 0.4 2.5 1.4 1.0 0.9 5.6 5.7 5.3 6.5 5.3 8.1 5.8 6.3 6.5 5.2 7.9 6.0 23.2 9.6 8.3 23.5 23.2 18.0 5.9 7.5 19.4 14.0 13.6 11.7 8.8 5.7 6.0 11.0 45.9 6.3 24.0 7.6 1.9 6.1 28.2 9.9 19.6 23.2 8.4 5.7 38.5 6.7 10.5 9.4 9.2 16.8 3.8 20.8 20.0 3.1 16.0 13.5 39.1 4.9 2.0 59.1 43.2 42.0 7.8 41.2 16.0 45.0 46.8 13.2 22.6 26.2 19.6 10.6 11.6 12.8 19.7 8.0 5.1 5.4 4.8 33.3 26.3 11.6 22.7 38.0 36.2 18.5 21.9 7.0 24.9 10.6 5.1 10.9 CBLB "Cbl-b, RNF56" ENSG00000114423 "Cbl proto-oncogene B" Q13191 3 105655461-105869552 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "dendritic cells: 113.7;Inhibitory neurons: 112.5;Oligodendrocyte precursor cells: 123.1;T-cells: 111.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "U-138 MG: 32.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018327, HPA019880" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 20: HeLa - Mitochondria" "Cluster 24: Non-specific - Transcription regulation" Cytosol Nucleoplasm "HPA018327: AB_1846097, HPA019880: AB_1846099" "unprognostic (2.65e-1)" "unprognostic (9.42e-2)" "unprognostic (1.72e-2)" "unprognostic (2.38e-1)" "unprognostic (5.89e-3)" "unprognostic (2.80e-2)" "unprognostic (8.18e-2)" "unprognostic (1.10e-1)" "unprognostic (7.05e-2)" "unprognostic (1.66e-1)" "unprognostic (9.29e-2)" "unprognostic (1.50e-2)" "unprognostic (1.43e-2)" "unprognostic (8.21e-2)" "unprognostic (2.83e-1)" "unprognostic (1.20e-2)" "unprognostic (3.09e-2)" 17.3 5.8 5.6 6.7 4.6 11.9 11.0 17.4 5.9 6.8 5.8 6.3 6.2 6.3 4.3 3.5 8.8 8.4 12.2 5.2 7.3 4.3 4.4 9.9 14.5 4.4 5.3 10.0 3.6 2.3 3.8 6.5 5.7 4.7 5.1 9.2 6.7 2.3 7.8 6.8 8.2 3.0 2.0 8.5 8.3 6.4 6.5 4.3 9.1 5.1 6.9 10.0 6.5 4.0 2.4 3.2 10.7 5.4 11.8 12.1 6.8 7.6 4.0 2.3 3.7 4.1 2.6 5.2 5.4 4.2 3.6 3.9 1.5 1.4 2.8 3.8 4.0 2.8 16.1 2.7 17.7 2.0 2.0 11.9 4.3 6.2 16.7 8.5 7.9 5.2 3.0 15.5 5.0 2.8 2.9 1.3 3.6 2.9 4.4 6.1 3.1 0.9 5.9 10.2 8.2 8.9 9.5 1.1 11.9 7.3 2.4 4.3 4.8 32.0 2.6 4.5 2.0 8.8 0.7 8.3 8.6 1.7 2.1 0.7 1.4 2.8 8.9 0.9 7.9 2.1 4.6 5.1 1.3 4.8 3.9 7.0 1.0 10.2 2.0 3.1 5.7 1.7 5.6 4.6 17.4 5.9 5.2 7.3 4.4 5.3 5.7 2.0 6.5 4.0 26.0 16.0 6.1 57.8 43.1 10.8 6.9 35.6 25.6 42.6 12.0 9.7 43.7 2.8 13.7 12.9 27.1 10.1 113.7 12.8 5.9 8.4 34.1 20.9 47.0 34.0 12.6 10.8 48.9 7.8 83.2 55.2 43.8 26.4 8.8 21.3 33.2 8.1 13.9 3.3 112.5 18.8 6.1 13.5 17.1 14.4 7.5 14.6 16.0 74.9 9.0 7.5 59.8 123.1 100.3 15.5 8.6 10.9 53.1 8.9 17.6 3.9 20.2 28.9 6.6 23.6 28.9 11.1 13.3 10.3 7.0 45.4 111.5 5.5 9.9 7.0 CBLC "CBL-3, CBL-SL, RNF57" ENSG00000142273 "Cbl proto-oncogene C" Q9ULV8 19 44777869-44800652 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 39.3;intestine: 50.9;skin 1: 42.4" "Cell type enhanced" "Detected in many" "Distal enterocytes: 108.6;Pancreatic endocrine cells: 95.0;Paneth cells: 108.1;Proximal enterocytes: 154.6;Undifferentiated cells: 67.1;Urothelial cells: 76.9" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A-431: 43.6;BEWO: 28.9;CACO-2: 28.3;CAPAN-2: 56.9;HaCaT: 41.0;HBEC3-KT: 34.8;hTCEpi: 26.0;OE19: 37.3;RT4: 34.7;SK-BR-3: 31.1" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB008087, HPA035266" Approved Approved Nucleoplasm,Aggresome NA NA "Cluster 37: Intestine - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm Aggresome "CAB008087: AB_2228531, HPA035266: AB_2674542" "unprognostic (1.58e-1)" "unprognostic (2.25e-1)" "unprognostic (8.21e-3)" "unprognostic (1.55e-1)" "unprognostic (3.04e-2)" "unprognostic (3.91e-2)" "unprognostic (1.67e-1)" "unprognostic (2.13e-2)" "unprognostic (3.82e-1)" "unprognostic (7.39e-2)" "unprognostic (1.06e-2)" "unprognostic (1.85e-1)" "prognostic favorable (3.11e-6)" "unprognostic (3.50e-1)" "unprognostic (8.25e-3)" "unprognostic (2.90e-2)" "unprognostic (2.21e-3)" 0.1 0.1 0.0 3.1 0.0 0.0 5.1 0.0 0.1 8.0 0.0 25.0 50.9 0.9 0.1 39.3 2.5 4.4 0.0 0.0 0.0 7.4 21.1 1.3 0.0 0.0 0.0 0.1 20.6 1.6 0.5 0.4 0.0 11.8 11.7 0.1 13.3 2.4 0.1 42.4 38.6 0.6 0.0 0.0 17.7 0.7 0.0 0.3 1.7 0.0 4.0 8.3 18.4 0.0 43.6 0.0 0.0 0.1 0.0 0.0 28.9 0.0 0.0 0.0 0.0 28.3 56.9 0.0 0.0 0.0 0.0 41.0 0.0 34.8 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 26.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 37.3 0.0 0.0 0.0 0.0 0.0 34.7 0.4 0.1 0.0 31.1 0.0 0.2 22.5 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 2.6 0.0 0.1 15.0 44.0 30.8 16.5 0.0 9.3 7.4 0.2 4.3 27.7 7.3 0.0 5.8 0.2 108.6 1.9 53.8 0.1 7.0 1.3 0.9 17.4 0.0 0.4 48.9 2.3 0.5 59.7 15.5 0.0 0.0 0.0 11.1 0.3 0.0 0.9 40.0 18.3 0.0 1.4 0.3 0.0 0.4 0.0 0.0 0.6 0.0 0.0 1.0 0.3 95.0 108.1 0.0 0.1 34.4 154.6 17.2 9.8 0.0 0.0 0.0 1.3 0.0 2.6 29.9 25.7 2.5 0.7 0.0 67.1 76.9 CBLL1 "FLJ23109, HAKAI, RNF188" ENSG00000105879 "Cbl proto-oncogene like 1" Q75N03 7 107743949-107761667 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Developmental protein, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021773, HPA026699" Enhanced Supported "Nuclear speckles" NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 59: Non-specific - Transcription" "Nuclear speckles" "HPA021773: AB_1846103, HPA026699: AB_1846104" "unprognostic (1.90e-2)" "unprognostic (2.25e-1)" "unprognostic (8.57e-2)" "unprognostic (3.79e-2)" "unprognostic (8.16e-2)" "unprognostic (7.20e-2)" "unprognostic (1.37e-2)" "unprognostic (3.96e-3)" "unprognostic (4.28e-2)" "unprognostic (2.16e-3)" "unprognostic (1.29e-1)" "unprognostic (1.31e-1)" "unprognostic (2.12e-3)" "unprognostic (9.12e-2)" "unprognostic (2.07e-1)" "unprognostic (1.09e-1)" "unprognostic (8.71e-2)" 11.2 8.1 3.1 12.5 5.3 40.0 15.1 7.8 9.5 12.0 3.0 11.3 9.5 13.5 8.4 11.3 11.2 8.7 10.4 4.2 5.8 10.0 11.2 10.3 16.1 4.1 3.7 14.3 11.7 14.1 5.1 12.0 4.1 16.5 11.1 14.4 8.9 12.7 29.0 10.7 10.3 13.4 3.0 14.2 9.2 19.7 3.7 20.2 13.8 21.0 17.8 11.9 7.2 6.6 27.8 31.1 23.7 30.7 21.7 18.6 16.2 20.5 21.6 22.8 22.5 21.4 27.9 40.6 28.5 23.5 37.6 19.3 33.4 25.0 31.0 28.4 21.1 32.5 23.0 18.2 24.9 49.1 30.9 19.6 22.7 30.7 33.0 17.6 23.8 27.8 53.0 33.3 22.4 48.0 66.5 34.4 34.4 23.3 21.3 30.6 25.4 42.0 17.4 25.5 25.4 39.6 30.7 44.9 23.4 27.7 15.1 24.7 23.4 35.0 25.0 33.4 32.0 53.0 62.3 64.1 21.3 29.8 30.3 88.8 31.1 53.3 39.5 32.0 58.2 39.0 61.9 45.8 36.9 39.8 41.8 40.0 48.9 55.1 38.0 20.1 92.6 48.4 3.1 5.3 7.8 9.5 4.2 5.8 4.1 3.7 4.1 3.0 3.7 6.6 18.2 19.2 11.0 6.5 29.6 23.6 16.7 10.5 27.3 12.2 15.9 13.7 16.4 17.2 10.7 3.7 4.2 10.3 27.6 9.9 7.9 9.7 12.4 15.6 19.8 13.5 16.8 39.1 13.9 10.8 9.5 12.6 10.7 13.7 13.3 16.6 12.5 11.0 10.7 10.1 13.1 8.0 8.2 23.3 12.4 5.4 9.3 15.1 19.6 15.9 15.0 7.6 25.7 10.1 20.5 10.1 15.0 11.7 17.3 16.2 8.5 11.2 8.9 14.4 19.7 13.2 14.5 27.2 14.3 19.5 19.9 10.3 27.3 9.5 10.0 18.4 CBLL2 "CT138, FLJ25735, HAKAIL, ZNF645" ENSG00000175809 "Cbl proto-oncogene like 2" Q8N7E2 X 22272913-22274461 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 20 "testis: 8.5" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 40: Granulosa cells - Unknown function" 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 CCNB1IP1 "C14orf18, HEI10" ENSG00000100814 "Cyclin B1 interacting protein 1" Q9NPC3 14 20311368-20333312 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Meiosis, Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "hTERT-HME1: 381.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 1: Thyroid gland - Transcription" "Cluster 30: Epithelial cell lines - Translation" "Cluster 32: Non-specific - Translation" "unprognostic (4.79e-2)" "unprognostic (1.35e-1)" "unprognostic (1.29e-1)" "unprognostic (9.37e-2)" "unprognostic (5.46e-3)" "unprognostic (2.79e-2)" "unprognostic (8.43e-2)" "unprognostic (5.88e-2)" "unprognostic (1.56e-1)" "unprognostic (1.88e-2)" "unprognostic (4.87e-2)" "unprognostic (4.77e-2)" "prognostic favorable (5.18e-6)" "unprognostic (2.12e-1)" "unprognostic (1.54e-2)" "unprognostic (4.43e-1)" "unprognostic (1.52e-1)" 31.3 20.0 31.7 10.6 32.8 35.5 58.1 31.8 44.3 52.6 38.4 35.3 21.3 43.0 48.4 27.3 53.2 20.8 74.7 31.1 35.3 66.4 74.9 36.9 25.3 34.7 32.7 99.4 45.3 51.3 22.2 31.3 34.9 38.1 30.1 21.2 29.6 24.4 52.2 35.5 24.7 29.9 32.7 20.4 31.0 23.3 31.8 32.0 57.4 63.4 30.7 40.0 41.7 34.4 30.8 24.7 137.5 133.3 68.9 94.1 110.3 37.0 73.6 55.5 72.8 83.2 33.4 106.2 23.9 27.1 55.6 53.8 96.6 69.9 74.3 30.9 82.0 63.1 22.6 79.7 201.7 117.5 56.6 128.8 114.6 39.6 381.3 67.3 42.6 125.7 77.7 82.1 37.0 48.9 68.5 79.3 83.2 66.5 46.6 82.9 67.9 45.5 58.7 44.6 109.0 113.6 25.5 58.5 170.7 75.8 18.7 84.5 18.4 31.6 40.1 38.4 48.8 38.3 51.0 72.6 10.6 97.3 37.1 6.3 4.2 0.1 8.2 1.4 10.9 11.6 9.0 10.3 17.7 9.8 9.2 13.0 0.6 6.0 1.6 18.2 13.3 3.8 31.7 32.8 31.8 44.3 31.1 35.3 34.7 32.7 34.9 32.7 31.8 34.4 22.2 28.9 27.2 16.3 35.5 58.1 74.0 45.5 113.3 4.2 57.0 71.9 30.9 58.6 21.0 23.9 20.9 41.2 27.7 15.1 103.7 31.8 64.2 13.0 37.6 24.9 41.3 34.7 22.2 38.2 70.6 34.5 23.0 20.2 34.9 76.7 20.0 35.3 17.8 1.7 28.5 40.1 28.5 23.3 26.5 92.8 51.6 22.4 51.6 7.5 17.8 46.9 30.9 15.1 19.7 29.3 18.8 44.0 17.4 63.5 21.0 86.5 5.2 17.6 46.0 36.6 31.6 101.0 77.5 67.0 40.1 34.1 28.7 61.1 44.3 51.3 CD38 ENSG00000004468 "CD38 molecule" P28907 4 15778275-15853232 "Cancer-related genes, CD markers, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Receptor, Transferase" "Cancer-related genes, Diabetes mellitus" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 63.3" "Cell type enriched" "Detected in many" 4 "Plasma cells: 378.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "NK-cell: 18.3" "Group enriched" "Detected in all" 5 "B-cells: 9.9;dendritic cells: 5.8;NK-cells: 18.3" "Cell line enhanced" "Detected in some" "Daudi: 128.0;Karpas-707: 34.7;MOLT-4: 32.6;REH: 26.0;RPMI-8226: 20.9;U-266/70: 26.9;U-698: 24.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002493, HPA022132, CAB025255, HPA052381" Enhanced Supported "Plasma membrane" NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 3: T-cells - Adaptive immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 55: Plasma cells - Humoral immune response" "Plasma membrane" "CAB002493: AB_563556, CAB025255: , HPA022132: AB_1846300, HPA052381: AB_2681807" "unprognostic (1.27e-2)" "unprognostic (8.06e-3)" "unprognostic (1.06e-2)" "prognostic favorable (9.68e-4)" "unprognostic (1.13e-1)" "unprognostic (1.82e-3)" "unprognostic (2.74e-1)" "unprognostic (8.51e-2)" "unprognostic (5.87e-2)" "unprognostic (6.15e-6)" "unprognostic (5.23e-1)" "unprognostic (4.34e-1)" "unprognostic (6.63e-6)" "unprognostic (1.79e-1)" "unprognostic (5.74e-2)" "unprognostic (2.12e-2)" "unprognostic (2.13e-1)" 3.1 2.4 2.5 13.1 3.8 13.6 2.0 2.7 2.5 0.7 0.9 4.5 5.8 0.9 1.2 1.1 3.0 1.9 3.8 3.5 6.6 0.8 3.3 6.3 23.4 3.3 5.5 0.7 0.3 0.1 1.8 0.5 3.4 13.2 3.5 0.2 2.6 19.7 21.4 0.3 5.3 1.4 2.8 17.0 3.0 1.0 3.9 63.3 2.0 3.4 18.0 6.8 0.5 4.6 0.0 11.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 128.0 0.0 0.0 0.4 0.1 0.2 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.0 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 17.0 0.2 34.7 0.0 0.0 32.6 7.9 0.2 0.0 0.0 26.0 0.1 20.9 0.0 0.0 0.2 1.5 0.0 0.2 0.5 0.3 0.1 5.7 0.5 0.0 0.1 0.1 0.0 26.9 0.2 24.3 0.4 6.2 0.3 0.1 1.9 0.1 1.2 2.4 0.3 9.9 1.5 1.2 4.7 7.7 2.4 1.9 1.4 18.3 1.9 5.8 2.4 4.4 2.5 3.8 2.7 2.5 3.5 6.6 3.3 5.5 3.4 2.8 3.9 4.6 0.8 3.2 15.1 86.5 59.7 0.0 0.4 0.6 0.6 0.1 0.1 0.0 1.0 0.0 11.6 0.0 10.4 0.2 33.8 0.2 0.0 0.0 2.5 4.0 1.4 2.7 0.0 78.6 0.4 0.0 0.2 2.7 2.0 0.3 38.2 0.8 2.9 4.3 4.4 0.0 0.4 1.3 0.0 44.3 0.8 0.7 0.0 17.7 7.2 5.6 3.1 0.0 79.3 1.0 1.8 0.0 0.3 0.0 378.4 8.1 0.2 0.1 42.5 0.1 13.1 1.5 7.6 2.9 1.7 1.6 0.0 0.5 26.5 0.0 1.6 0.2 CDC34 "E2-CDC34, UBC3, UBE2R1" ENSG00000099804 "Cell division cycle 34, ubiqiutin conjugating enzyme" P49427 19 531760-542092 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Late spermatids: 249.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002382, CAB005109, CAB047311, HPA074334" Approved Supported "Nucleoplasm,Nuclear speckles,Cytosol" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 1: K-562 - Erythropoiesis" "Cluster 10: Non-specific - Unknown function" "Nucleoplasm, Nuclear speckles" Cytosol "CAB005109: AB_2276050, CAB047311: , HPA002382: AB_1846370, HPA074334: " "unprognostic (4.65e-2)" "unprognostic (2.02e-1)" "unprognostic (1.41e-1)" "unprognostic (8.72e-2)" "unprognostic (2.84e-1)" "unprognostic (5.73e-2)" "prognostic unfavorable (7.57e-4)" "unprognostic (2.20e-1)" "unprognostic (3.11e-1)" "unprognostic (3.83e-2)" "unprognostic (2.09e-2)" "unprognostic (3.06e-2)" "unprognostic (3.02e-2)" "unprognostic (8.87e-3)" "unprognostic (9.68e-2)" "unprognostic (7.82e-3)" "unprognostic (3.33e-2)" 35.1 36.7 52.0 13.3 51.2 34.5 34.2 51.5 63.0 36.9 47.5 62.5 17.8 33.5 14.1 40.5 33.6 10.1 80.0 52.7 48.7 32.1 88.0 32.1 12.5 51.0 50.7 35.6 58.5 18.7 43.4 29.2 50.8 36.9 11.5 28.2 34.2 19.3 105.0 51.8 27.6 18.5 48.2 31.0 38.6 100.2 52.7 16.4 26.7 63.2 9.7 43.7 34.2 52.7 54.8 54.6 66.4 54.7 29.2 28.4 68.5 47.8 36.1 50.2 51.9 86.1 32.8 29.5 49.3 34.1 30.1 36.9 52.1 40.2 25.0 49.2 146.0 27.8 35.5 94.5 73.6 39.0 32.4 36.4 58.9 42.2 43.6 38.8 60.6 41.2 120.3 57.5 33.8 80.7 53.3 53.6 85.3 39.4 51.7 49.1 35.1 51.2 38.0 32.4 87.2 65.9 41.5 42.1 85.2 53.2 34.0 57.4 50.5 36.5 43.7 86.2 65.2 57.7 47.3 40.1 50.0 55.6 38.8 3.2 2.5 4.7 1.6 2.7 1.1 2.3 2.1 2.9 2.0 1.0 1.6 1.6 8.2 1.2 3.5 1.6 2.5 1.0 52.0 51.2 51.5 63.0 52.7 48.7 51.0 50.7 50.8 48.2 52.7 52.7 39.4 0.0 5.4 21.9 11.4 46.8 17.5 5.4 16.5 35.5 43.4 47.1 27.7 27.1 3.5 14.7 25.0 44.3 30.9 47.4 13.7 24.9 63.9 29.6 28.3 27.7 13.2 77.7 8.3 20.5 55.4 21.4 16.8 42.3 0.0 28.1 15.7 41.1 27.9 16.8 6.3 34.0 14.2 14.5 38.6 249.4 18.0 20.6 19.6 2.8 15.1 68.9 20.6 6.6 12.9 45.0 27.0 15.1 25.0 34.8 25.9 18.9 5.5 44.3 13.1 22.6 34.9 22.4 54.6 15.2 54.7 63.1 22.0 27.1 23.7 27.9 CDC42BPA "FLJ23347, KIAA0451, MRCK, MRCKA, PK428" ENSG00000143776 "CDC42 binding protein kinase alpha" Q5VT25 1 226989865-227318474 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 320.3;Excitatory neurons: 447.6;Inhibitory neurons: 479.0;Oligodendrocyte precursor cells: 444.3;Oligodendrocytes: 671.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB070414, HPA071252" Approved Approved "Intermediate filaments" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 78: Testis - Spermatogenesis" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Intermediate filaments" "CAB070414: AB_11156796, HPA071252: AB_2686374" "unprognostic (3.67e-3)" "unprognostic (1.45e-1)" "unprognostic (1.10e-1)" "unprognostic (2.78e-2)" "unprognostic (3.04e-1)" "unprognostic (5.90e-2)" "unprognostic (7.89e-2)" "unprognostic (2.27e-1)" "unprognostic (1.46e-1)" "unprognostic (3.93e-1)" "unprognostic (4.88e-2)" "unprognostic (2.87e-2)" "unprognostic (7.73e-3)" "unprognostic (1.35e-1)" "unprognostic (1.70e-1)" "unprognostic (9.79e-2)" "unprognostic (1.21e-2)" 15.6 12.5 26.3 5.5 32.4 3.5 12.2 33.5 30.0 15.8 12.2 21.2 14.7 15.0 7.7 10.1 12.6 13.7 16.4 24.9 25.2 17.3 14.7 12.3 2.0 25.7 26.8 14.0 13.1 19.7 14.6 12.7 27.0 15.8 10.3 23.7 7.6 14.9 11.4 6.3 12.9 14.5 19.8 6.6 22.4 24.4 29.7 2.2 8.1 13.6 1.8 23.0 11.3 37.0 22.6 21.1 21.9 10.4 21.5 26.4 7.7 25.4 35.7 17.2 17.9 17.1 50.1 0.1 26.6 42.4 13.0 10.3 16.3 14.2 20.9 0.1 13.2 17.4 25.5 6.7 24.3 14.1 7.5 18.6 17.9 27.8 27.8 21.3 58.0 13.6 45.1 0.1 28.2 6.2 0.4 2.5 18.0 29.3 20.0 0.0 37.0 0.1 27.7 43.1 15.7 22.9 43.0 17.8 24.8 13.4 23.1 0.8 59.0 31.3 16.2 36.1 33.9 0.1 0.1 0.1 41.4 0.0 42.7 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 26.3 32.4 33.5 30.0 24.9 25.2 25.7 26.8 27.0 19.8 29.7 37.0 82.6 41.7 35.7 320.3 0.8 11.7 26.0 15.9 12.0 97.7 14.0 12.8 59.9 30.0 38.9 44.1 118.9 5.9 1.8 49.3 13.7 26.0 128.0 18.7 45.1 68.4 26.4 45.6 447.6 41.1 7.3 44.4 92.8 25.7 7.0 21.5 47.8 28.9 3.7 223.8 479.0 30.5 22.4 4.4 9.9 132.3 44.1 6.4 16.0 180.8 5.9 33.4 0.0 444.3 671.8 65.1 74.0 85.4 1.8 30.1 50.7 41.3 24.8 66.9 78.9 64.0 68.4 45.6 57.7 8.0 8.0 1.4 1.3 23.4 34.4 43.1 CDC42BPB "KIAA1124, MRCKB" ENSG00000198752 "CDC42 binding protein kinase beta" Q9Y5S2 14 102932380-103057549 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA022821 Approved NA NA 12000 "Cluster 7: Monocytes - Unknown function" "Cluster 57: Non-specific - Angiogenesis" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 44: Endometrium - Transcription" "HPA022821: AB_1846376" "unprognostic (6.73e-2)" "unprognostic (2.19e-2)" "unprognostic (6.99e-2)" "unprognostic (5.67e-2)" "unprognostic (1.41e-2)" "unprognostic (2.19e-1)" "unprognostic (2.90e-2)" "prognostic unfavorable (2.38e-4)" "unprognostic (2.71e-1)" "unprognostic (1.24e-1)" "unprognostic (3.46e-2)" "unprognostic (2.28e-1)" "prognostic favorable (8.67e-10)" "unprognostic (2.11e-1)" "unprognostic (1.86e-1)" "unprognostic (8.59e-2)" "unprognostic (7.56e-2)" 38.7 31.3 42.7 17.8 42.5 3.6 31.2 31.2 40.2 33.5 21.0 35.8 30.2 38.0 17.9 37.8 31.3 29.5 36.3 44.3 36.4 32.3 28.9 32.9 9.8 38.6 40.2 33.4 33.1 34.2 32.5 29.5 35.7 28.7 20.2 24.1 27.9 30.4 27.2 33.0 34.9 32.3 38.5 22.2 32.0 25.2 40.8 8.6 29.6 24.2 12.6 35.0 33.2 46.1 42.8 83.8 52.7 38.7 57.3 65.1 53.0 47.9 50.3 49.7 45.4 28.8 49.0 0.0 51.1 93.7 37.7 53.0 54.9 57.2 52.3 52.2 24.8 23.4 68.0 29.0 62.2 0.2 24.1 56.7 57.6 51.0 48.5 52.2 97.7 9.8 19.3 11.7 48.3 89.2 0.4 5.4 25.3 66.5 68.4 0.2 44.3 1.2 63.1 82.6 38.2 41.6 85.1 31.6 35.8 55.7 48.7 14.9 125.3 47.3 31.6 105.8 45.3 15.1 17.4 12.4 53.2 5.2 46.9 0.0 0.2 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 42.7 42.5 31.2 40.2 44.3 36.4 38.6 40.2 35.7 38.5 40.8 46.1 57.1 57.7 35.8 37.5 7.8 14.5 16.5 14.5 17.6 45.8 19.1 15.4 28.8 28.6 27.4 55.2 33.3 12.6 0.5 35.4 3.9 29.8 14.2 35.8 55.0 46.3 25.2 11.0 40.3 21.8 11.1 25.7 32.1 59.4 13.3 37.8 36.0 20.5 12.8 57.2 33.1 16.1 30.5 13.5 14.7 7.9 32.3 21.7 12.4 31.9 11.1 29.3 0.0 31.7 74.6 44.2 15.4 55.3 3.5 26.1 28.2 15.4 28.1 42.3 6.6 38.6 29.3 15.5 17.0 27.2 18.3 16.8 3.2 37.3 27.5 32.4 CDC42BPG "DMPK2, HSMDPKIN, kappa-200, MRCKgamma" ENSG00000171219 "CDC42 binding protein kinase gamma" Q6DT37 11 64823052-64844653 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skin 1: 33.7" "Cell type enhanced" "Detected in many" "Distal enterocytes: 14.8;Gastric mucus-secreting cells: 23.0;Paneth cells: 18.3;Squamous epithelial cells: 19.3" "Low cancer specificity" "Detected in many" "Region enriched" "Detected in some" 8 "cerebellum: 9.7" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 29.3;HaCaT: 22.5;MCF7: 30.7;RT4: 18.4;SK-BR-3: 18.4;T-47d: 18.1" "Region enriched" "Detected in all" 4 "cerebellum: 10.5" "Low region specificity" "Detected in some" "HPA027382, HPA061836" Enhanced Supported Cytosol NA NA "Cluster 31: Skin - Epidermis development" "Cluster 28: BEWO - Transcription regulation" "Cluster 61: Squamous epithelial cells - Keratinization" Cytosol "HPA027382: AB_1846378, HPA061836: AB_2684622" "unprognostic (3.26e-2)" "unprognostic (1.58e-1)" "unprognostic (6.00e-2)" "unprognostic (2.60e-1)" "unprognostic (1.21e-1)" "unprognostic (2.50e-1)" "unprognostic (4.68e-1)" "unprognostic (5.27e-2)" "unprognostic (3.91e-2)" "unprognostic (3.65e-2)" "unprognostic (1.26e-1)" "unprognostic (1.81e-1)" "prognostic favorable (5.99e-13)" "unprognostic (2.60e-2)" "unprognostic (1.55e-1)" "unprognostic (2.14e-2)" "unprognostic (3.99e-3)" 0.5 4.9 0.2 1.4 0.3 2.1 4.8 9.7 1.2 5.4 5.5 8.8 10.6 0.4 2.0 26.5 3.8 2.8 0.4 0.4 0.3 7.7 0.9 7.8 1.3 0.4 0.7 2.2 14.1 6.4 11.0 4.2 1.0 8.5 4.5 0.3 17.7 3.7 0.2 33.7 9.3 0.2 0.3 1.8 12.2 3.3 0.3 2.4 6.0 0.0 2.0 5.8 13.0 0.3 8.9 1.2 0.8 0.0 0.0 0.0 29.3 0.0 0.0 0.0 0.0 11.7 7.5 0.1 4.3 0.0 0.4 22.5 1.3 8.8 0.0 0.4 3.6 0.7 5.3 3.8 0.0 0.3 2.2 0.0 10.9 0.1 0.1 0.1 0.1 3.5 6.1 0.1 0.0 30.7 0.2 1.7 2.7 8.3 1.3 1.3 0.5 4.3 5.5 18.4 15.6 0.7 2.8 18.4 0.5 4.3 18.1 0.4 0.1 0.0 3.1 0.1 0.1 2.1 2.2 2.2 0.0 0.3 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 9.7 1.2 0.4 0.3 0.4 0.7 1.0 0.3 0.3 0.3 1.0 9.6 7.9 0.0 1.2 6.5 2.3 3.6 9.6 0.0 5.1 5.8 1.8 2.8 9.6 1.8 0.0 6.4 1.7 14.8 0.0 2.4 0.6 13.2 0.7 0.4 3.6 0.8 0.1 6.2 4.9 0.7 23.0 7.9 1.3 0.4 0.0 0.0 1.0 0.0 0.1 4.8 2.0 0.0 0.4 0.8 0.0 1.3 0.0 0.0 1.2 0.8 1.0 0.0 0.1 2.9 18.3 0.0 0.1 1.6 12.4 0.5 9.5 0.0 0.0 2.2 0.8 1.7 1.3 19.3 8.1 6.7 1.4 0.6 5.7 3.4 CDC7 "CDC7L1, HsCdc7, Hsk1, huCdc7" ENSG00000097046 "Cell division cycle 7" O00311 1 91500851-91525764 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 16.9" "Cell type enhanced" "Detected in many" "Early spermatids: 37.8;Erythroid cells: 23.1;Spermatocytes: 30.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002669, HPA035831" Enhanced Supported "Nucleoplasm,Cytokinetic bridge,Mitotic spindle" Yes No "Cluster 20: T-cells - T-cell receptor" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 30: Mammary glandular cells - Lactation" Nucleoplasm "Cytokinetic bridge, Mitotic spindle" "CAB002669: , HPA035831: AB_2674807" "unprognostic (6.84e-2)" "unprognostic (6.01e-2)" "unprognostic (4.64e-2)" "unprognostic (7.02e-3)" "unprognostic (5.57e-2)" "unprognostic (3.57e-3)" "prognostic unfavorable (3.15e-6)" "unprognostic (6.52e-2)" "unprognostic (2.23e-2)" "unprognostic (1.36e-3)" "unprognostic (2.04e-2)" "unprognostic (1.75e-2)" "prognostic unfavorable (1.89e-15)" "unprognostic (9.44e-3)" "unprognostic (2.49e-2)" "unprognostic (1.09e-1)" "unprognostic (5.39e-2)" 1.9 2.7 3.6 6.0 3.8 13.8 2.1 6.3 4.8 2.1 1.6 3.0 3.1 1.8 1.7 3.5 1.3 1.7 1.4 3.8 3.4 4.3 1.5 4.2 9.3 2.9 3.7 2.5 1.6 0.8 4.0 5.9 3.1 1.9 4.6 14.1 1.7 1.4 0.5 5.1 3.7 2.4 2.8 12.1 1.8 16.9 3.2 10.9 1.7 0.5 9.4 2.4 2.3 3.5 32.0 9.4 59.1 17.3 1.4 7.6 18.8 12.0 9.1 22.6 24.3 19.6 10.8 22.5 16.1 7.7 19.8 13.7 39.8 13.5 29.4 36.8 34.3 33.7 27.9 9.5 2.1 37.0 11.9 4.2 4.0 21.0 11.9 4.1 8.9 30.9 44.8 31.4 15.2 11.8 31.5 33.5 48.9 17.2 21.6 38.9 49.5 14.5 10.2 24.0 44.7 18.6 37.5 10.2 21.6 14.3 9.8 18.2 7.3 25.8 22.7 20.6 17.9 11.6 15.6 57.9 9.4 36.0 9.4 0.0 1.0 0.0 3.8 0.7 3.2 0.9 2.8 3.5 2.3 0.9 1.5 3.0 0.1 1.6 0.2 1.4 4.6 1.4 3.6 3.8 6.3 4.8 3.8 3.4 2.9 3.7 3.1 2.8 3.2 3.5 1.9 0.0 1.1 3.3 3.2 5.9 1.2 2.7 3.4 8.2 14.4 1.4 2.1 0.0 1.3 1.8 0.0 8.2 4.1 0.6 3.9 1.5 37.8 1.1 4.9 4.1 0.0 23.1 18.3 2.6 6.3 3.1 2.6 1.9 4.5 15.4 4.2 0.2 2.7 3.3 19.6 1.8 6.1 2.2 2.9 18.7 0.9 1.6 3.6 5.6 2.1 1.6 6.2 16.6 3.1 1.2 1.7 0.7 7.1 0.9 0.5 0.4 2.0 5.1 6.6 1.5 4.1 30.5 21.4 4.3 3.7 2.2 5.3 7.6 3.6 1.0 CDIPT "PIS, PIS1" ENSG00000103502 "CDP-diacylglycerol--inositol 3-phosphatidyltransferase" O14735 16 29858357-29863414 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA056597 Enhanced Approved "Nucleoplasm,Nuclear membrane,Plasma membrane" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 35: Non-specific - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 47: Cytotrophoblasts - Unknown function" "Nucleoplasm, Nuclear membrane, Plasma membrane" "HPA056597: AB_2683182" "unprognostic (7.81e-2)" "prognostic favorable (9.40e-4)" "unprognostic (1.93e-3)" "unprognostic (8.08e-3)" "unprognostic (1.50e-2)" "unprognostic (2.84e-2)" "unprognostic (7.60e-2)" "unprognostic (1.09e-2)" "unprognostic (7.03e-2)" "unprognostic (8.75e-2)" "unprognostic (5.56e-3)" "unprognostic (1.61e-1)" "unprognostic (6.17e-2)" "unprognostic (3.36e-2)" "unprognostic (6.95e-2)" "unprognostic (1.56e-1)" "unprognostic (2.48e-1)" 93.8 101.7 75.1 32.1 73.8 26.8 81.0 79.0 86.2 84.5 64.2 104.7 39.0 91.1 31.1 61.1 76.2 51.7 105.4 73.6 76.2 80.6 114.5 65.1 36.1 78.4 74.6 109.6 86.8 87.9 68.7 42.3 78.9 78.1 24.4 34.0 67.2 55.5 49.7 82.8 69.6 38.9 69.1 66.3 89.1 43.9 73.6 40.6 69.1 43.9 24.8 89.7 73.6 70.1 40.0 85.6 23.7 47.3 125.8 86.3 70.5 71.0 76.6 47.9 47.4 50.5 75.1 26.9 125.2 80.3 42.2 62.0 38.7 44.5 21.3 67.5 85.3 19.5 61.4 74.1 87.7 28.5 47.2 148.0 77.2 64.3 29.7 75.8 60.9 49.9 29.5 67.1 44.0 127.7 40.3 56.2 55.5 42.2 65.7 74.8 29.5 78.7 63.7 38.1 96.4 53.8 36.9 76.1 55.7 41.2 57.5 74.8 52.8 70.3 22.1 58.0 35.8 51.4 62.1 19.3 77.2 46.0 43.4 11.7 8.2 28.9 8.5 6.2 5.7 6.5 7.9 9.1 3.8 6.4 7.7 7.2 20.6 11.4 7.9 8.1 12.0 3.8 75.1 73.8 79.0 86.2 73.6 76.2 78.4 74.6 78.9 69.1 73.6 70.1 54.7 25.6 28.3 10.4 25.1 41.3 41.4 22.9 30.1 53.4 42.1 49.7 57.9 41.5 15.4 46.0 45.9 120.6 31.9 57.5 41.1 72.0 54.0 18.1 30.4 48.0 37.3 22.7 16.4 71.8 127.3 59.3 19.4 29.6 13.4 30.7 46.1 41.7 65.0 58.9 19.3 30.6 10.2 41.8 21.3 12.8 76.7 33.3 23.2 11.2 45.2 57.7 36.0 9.0 11.5 44.9 37.9 61.7 31.7 38.9 87.9 34.5 15.1 56.3 46.0 24.4 44.6 10.2 14.7 32.3 50.7 73.2 30.5 34.1 34.8 39.3 CDK1 "CDC2, CDC28A" ENSG00000170312 "Cyclin dependent kinase 1" P06493 10 60778331-60794852 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters" "Apoptosis, Biological rhythms, Cell cycle, Cell division, Host-virus interaction, Mitosis" "Host cell receptor for virus entry, Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 53.2;lymphoid tissue: 74.0" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 80.9;Erythroid cells: 209.6;Extravillous trophoblasts: 144.6;Spermatocytes: 110.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in some" "NK-cell: 3.2;T-reg: 3.4" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003387, CAB003799, CAB079974" Enhanced Supported Nucleoplasm,Cytosol NA Yes 51000 "Cluster 15: NK-cells - Transcription" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" "Nucleoplasm, Cytosol" "CAB003799: AB_344898, CAB079974: , HPA003387: AB_1846356" "unprognostic (6.34e-2)" "prognostic favorable (8.81e-4)" "unprognostic (1.90e-1)" "unprognostic (6.82e-2)" "unprognostic (6.67e-2)" "unprognostic (3.83e-2)" "prognostic unfavorable (1.10e-6)" "prognostic unfavorable (7.88e-4)" "unprognostic (1.30e-2)" "unprognostic (1.30e-1)" "prognostic unfavorable (4.15e-6)" "unprognostic (1.80e-2)" "prognostic unfavorable (0.00e+0)" "unprognostic (2.27e-1)" "unprognostic (2.75e-1)" "unprognostic (2.13e-1)" "unprognostic (1.60e-1)" 3.8 1.8 0.9 17.0 1.0 53.2 7.4 0.9 1.5 5.2 0.9 17.6 16.3 7.1 12.2 17.5 3.7 4.3 1.4 0.9 1.0 3.1 3.2 4.7 40.6 1.2 1.2 2.3 0.8 2.5 4.1 19.4 1.1 1.7 20.8 1.3 3.2 5.2 1.4 13.2 14.5 8.0 0.9 9.0 10.1 25.1 1.4 74.0 3.6 2.2 47.5 7.1 6.9 1.0 249.9 93.5 241.1 96.0 15.4 23.6 99.0 183.8 132.7 218.8 209.0 218.9 213.7 226.2 69.6 50.6 79.6 149.9 166.2 106.8 225.8 162.3 121.1 119.4 84.4 128.1 2.8 184.5 117.6 4.7 10.4 142.1 137.0 49.6 133.3 146.2 185.1 270.3 246.9 66.3 234.0 131.1 106.6 149.3 193.1 199.7 224.5 111.3 84.3 81.4 112.7 98.7 123.5 184.9 96.3 130.0 199.9 111.5 55.4 92.8 197.9 99.1 255.8 104.9 180.8 205.6 79.9 203.5 117.6 0.0 0.0 0.0 0.3 0.1 0.2 0.5 0.7 1.3 0.3 0.4 0.2 0.7 0.0 3.2 0.1 0.9 3.4 0.9 0.9 1.0 0.9 1.5 0.9 1.0 1.2 1.2 1.1 0.9 1.4 1.0 7.7 0.0 3.2 0.3 7.1 39.8 5.4 29.9 2.8 1.1 5.3 6.1 0.8 0.0 10.2 18.4 0.0 80.9 3.6 8.9 3.9 0.8 18.7 10.8 6.2 10.5 3.0 209.6 0.4 0.0 144.6 13.3 13.3 9.4 0.0 51.5 7.5 1.3 57.2 0.0 0.2 14.6 30.5 20.5 18.1 10.4 2.1 16.5 1.8 1.9 1.0 1.0 3.1 0.0 0.1 0.4 0.7 0.7 32.1 4.3 2.2 3.0 17.6 0.7 0.0 0.5 24.6 110.0 39.6 33.8 18.6 22.0 10.3 2.1 26.6 10.4 CDK10 PISSLRE ENSG00000185324 "Cyclin dependent kinase 10" Q15131 16 89680737-89696354 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cilium biogenesis/degradation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007451, HPA059634, HPA067060" Uncertain Supported "Nucleoplasm,Midbody,Midbody ring" Yes Yes "Cluster 27: Non-specific - Gene expression" "Cluster 18: Non-specific - Mitochondria" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 52: Non-specific - Transcription" Nucleoplasm "Midbody, Midbody ring" "HPA007451: AB_2732400, HPA059634: AB_2684090, HPA067060: AB_2685772" "unprognostic (7.89e-2)" "unprognostic (8.08e-2)" "unprognostic (3.74e-3)" "unprognostic (9.87e-2)" "unprognostic (1.76e-1)" "unprognostic (3.44e-2)" "unprognostic (4.53e-1)" "unprognostic (9.06e-2)" "unprognostic (2.99e-1)" "unprognostic (2.13e-1)" "prognostic favorable (2.69e-4)" "unprognostic (2.58e-2)" "unprognostic (2.93e-1)" "unprognostic (3.32e-2)" "unprognostic (1.79e-1)" "unprognostic (6.88e-2)" "prognostic favorable (3.63e-4)" 30.1 38.5 20.2 10.4 20.4 19.5 26.7 20.3 32.8 49.3 22.0 38.2 22.7 25.9 8.7 35.3 36.3 8.6 27.3 21.0 19.5 52.9 77.0 31.0 14.7 18.6 18.7 43.2 49.2 13.5 55.5 12.5 19.6 39.1 11.3 7.6 24.8 7.5 33.8 32.1 36.1 8.2 17.0 37.5 38.5 17.0 18.4 10.8 54.5 4.1 7.0 32.3 36.5 19.1 27.5 17.8 13.9 5.8 5.7 11.0 14.2 22.3 12.6 15.2 4.9 13.1 21.2 23.9 9.8 19.3 9.1 15.5 5.8 30.8 9.3 5.3 14.1 9.7 21.0 1.7 23.4 15.8 17.1 13.3 10.7 9.3 15.3 10.3 27.0 16.1 25.5 3.2 17.7 36.6 19.5 45.0 28.5 29.7 13.1 26.5 19.0 34.1 27.9 21.2 10.1 29.6 28.0 13.0 6.8 15.2 30.3 25.0 24.1 9.1 26.6 10.1 15.4 11.7 6.4 7.5 16.4 25.0 15.5 5.1 14.0 4.2 14.8 19.7 12.8 7.8 13.2 10.7 18.1 9.0 15.1 12.6 1.5 20.4 15.4 12.4 11.6 11.4 20.2 20.4 20.3 32.8 21.0 19.5 18.6 18.7 19.6 17.0 18.4 19.1 28.2 12.8 26.6 35.3 21.2 15.4 24.2 26.9 23.3 17.2 24.5 25.1 6.5 38.6 20.0 27.6 25.0 28.6 26.7 44.8 43.0 28.6 6.1 20.7 21.9 23.0 67.7 15.4 44.5 12.5 19.8 19.6 85.1 16.9 9.5 40.3 21.8 41.1 18.8 18.5 33.3 49.4 26.4 17.4 16.0 8.8 23.9 17.0 19.6 17.8 15.5 8.5 26.8 24.6 20.0 13.6 41.5 12.4 20.8 30.7 58.3 53.7 28.1 32.3 6.6 11.4 16.3 27.3 28.7 22.4 15.5 27.9 22.0 54.8 58.2 22.9 CDK11A "CDC2L2, CDC2L3, CDK11-p110, CDK11-p46, CDK11-p58, p58GTA, PITSLRE" ENSG00000008128 "Cyclin dependent kinase 11A" Q9UQ88 1 1702379-1724357 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 124.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 85.3" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "CAB010467, HPA025061, HPA073626" Supported Supported "Nuclear speckles,Cytosol" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 2: Immune cells - Immune response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 11: Alveolar cells - Smell perception" "Nuclear speckles" Cytosol "CAB010467: AB_631212, HPA025061: AB_1846407, HPA073626: AB_2686619" "unprognostic (6.25e-2)" "unprognostic (8.32e-2)" "unprognostic (1.47e-2)" "unprognostic (2.74e-1)" "unprognostic (9.32e-3)" "unprognostic (3.54e-2)" "unprognostic (2.25e-3)" "unprognostic (7.97e-2)" "prognostic unfavorable (5.06e-4)" "unprognostic (1.28e-1)" "unprognostic (5.58e-3)" "unprognostic (3.07e-2)" "prognostic unfavorable (1.15e-6)" "unprognostic (1.97e-1)" "unprognostic (5.98e-2)" "unprognostic (1.54e-1)" "unprognostic (3.70e-2)" 17.7 17.0 14.9 24.8 15.3 41.7 17.7 18.7 16.2 22.2 14.9 25.0 29.3 19.4 8.8 15.7 20.6 9.4 13.5 14.3 15.8 15.5 18.6 27.4 23.3 15.9 14.6 20.3 17.2 9.3 18.5 12.5 15.4 20.3 14.7 13.1 16.8 7.8 26.0 19.8 36.7 8.8 12.9 36.7 20.3 21.6 15.1 17.0 20.0 7.6 13.8 17.8 19.1 16.4 26.6 16.3 18.7 16.9 20.5 14.5 13.4 25.4 14.3 18.7 20.1 21.9 30.1 31.8 15.2 10.0 19.8 27.1 14.3 15.0 14.3 25.4 19.4 28.8 42.6 20.4 13.3 29.6 45.9 17.1 10.7 13.5 12.2 20.3 22.2 21.4 35.7 27.4 11.1 15.5 19.0 33.4 18.1 18.4 16.0 27.7 19.0 18.9 12.3 13.0 17.7 22.6 25.0 36.3 37.9 7.6 20.4 19.4 22.7 24.3 18.5 10.9 17.2 38.0 31.1 35.3 9.8 33.1 7.2 64.1 16.7 22.0 14.5 9.0 12.1 19.3 12.4 10.7 5.6 19.5 12.0 9.9 85.3 12.0 11.6 33.3 10.9 3.5 14.9 15.3 18.7 16.2 14.3 15.8 15.9 14.6 15.4 12.9 15.1 16.4 27.7 51.3 59.0 5.9 33.9 14.0 16.0 12.5 22.2 33.0 11.3 10.4 1.0 14.3 38.3 14.7 27.1 16.2 54.1 28.8 9.8 19.7 37.6 18.0 24.2 26.4 9.1 29.0 5.3 15.3 22.6 16.6 52.5 21.8 84.6 18.9 18.5 15.6 12.2 40.4 5.0 29.1 12.2 12.2 26.9 16.3 35.4 28.5 10.6 2.8 25.6 16.1 44.3 4.5 8.7 25.9 51.0 21.4 42.7 16.3 62.0 11.7 34.5 42.4 13.1 21.3 19.1 124.0 93.7 15.3 14.6 30.5 48.1 16.5 23.0 14.3 CDK11B "CDC2L1, CDK11-p110, CDK11-p46, CDK11-p58" ENSG00000248333 "Cyclin dependent kinase 11B" P21127 1 1635225-1659012 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 174.6;Spermatogonia: 176.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "HPA025061, HPA073626" Approved Approved "Nuclear speckles" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 59: Non-specific - Translation" "Cluster 20: HeLa - Mitochondria" "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" "Nuclear speckles" "HPA025061: AB_1846407, HPA073626: AB_2686619" "unprognostic (7.52e-3)" "unprognostic (4.85e-2)" "unprognostic (1.14e-1)" "unprognostic (2.02e-2)" "unprognostic (3.75e-2)" "prognostic favorable (1.14e-4)" "unprognostic (9.75e-3)" "unprognostic (1.14e-1)" "unprognostic (1.88e-1)" "unprognostic (1.48e-1)" "unprognostic (2.18e-1)" "unprognostic (1.14e-2)" "unprognostic (6.04e-2)" "unprognostic (8.45e-2)" "unprognostic (1.27e-1)" "unprognostic (7.19e-2)" "unprognostic (6.52e-3)" 31.8 29.0 20.6 17.6 20.8 43.0 30.0 18.1 20.9 32.4 16.6 46.1 25.6 35.9 5.8 30.3 31.6 9.9 39.6 18.3 20.2 28.2 32.1 41.0 19.5 21.2 19.8 33.4 35.0 8.9 30.5 10.6 20.7 31.7 9.4 9.0 28.4 12.7 85.9 39.3 44.6 10.4 20.4 47.7 34.5 49.8 20.8 13.2 30.8 17.8 10.6 37.9 30.8 21.6 47.2 36.4 21.9 17.4 17.8 12.0 30.6 43.7 18.8 24.0 20.8 41.3 43.7 40.8 43.9 18.7 16.9 35.4 18.6 22.0 18.4 36.3 40.4 43.9 68.9 36.1 24.1 50.4 44.3 16.1 15.8 26.2 19.9 14.1 24.5 42.3 51.9 26.9 14.4 31.0 47.9 42.5 38.9 13.8 43.7 46.9 43.4 33.5 12.7 16.6 28.3 36.4 40.3 36.7 42.3 15.0 25.2 33.4 37.4 29.8 33.0 22.7 43.0 60.5 58.7 85.6 37.4 55.9 23.2 7.2 3.3 5.3 6.1 2.8 2.7 3.3 3.8 3.6 2.8 3.7 4.1 3.1 13.8 4.4 3.2 5.1 3.2 1.6 20.6 20.8 18.1 20.9 18.3 20.2 21.2 19.8 20.7 20.4 20.8 21.6 35.2 19.2 43.1 13.7 42.9 14.4 19.5 10.2 25.6 32.0 22.2 18.3 42.9 30.0 31.7 27.6 20.9 27.7 44.7 86.6 9.8 33.3 39.7 28.1 34.2 32.3 28.8 25.0 14.1 35.2 31.5 25.1 48.9 36.3 55.6 24.1 25.7 38.6 20.5 15.2 12.3 73.8 10.2 30.1 14.5 25.6 28.9 33.9 5.4 15.0 36.3 20.5 76.2 10.1 18.2 37.4 93.3 26.7 54.7 19.6 95.4 19.2 29.4 42.4 52.6 25.9 31.0 174.6 176.5 27.5 17.3 44.6 48.9 16.5 56.9 15.9 CDK12 "CRK7, CRKR, CRKRS, KIAA0904" ENSG00000167258 "Cyclin dependent kinase 12" Q9NYV4 17 39461486-39564907 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "mRNA processing, mRNA splicing" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "SK-BR-3: 307.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008038, HPA073305" Supported Enhanced "Nucleoplasm,Nuclear speckles" NA NA "Cluster 17: Basophils - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 10: Non-specific - Unknown function" "Nucleoplasm, Nuclear speckles" "HPA008038: AB_1078570, HPA073305: " "unprognostic (2.02e-1)" "unprognostic (1.80e-1)" "unprognostic (2.61e-2)" "unprognostic (7.56e-2)" "unprognostic (1.05e-1)" "unprognostic (3.19e-1)" "unprognostic (2.56e-3)" "unprognostic (2.37e-2)" "unprognostic (3.86e-2)" "unprognostic (3.00e-3)" "unprognostic (6.87e-3)" "unprognostic (1.86e-1)" "unprognostic (3.06e-2)" "unprognostic (9.10e-2)" "unprognostic (1.24e-1)" "unprognostic (2.22e-2)" "unprognostic (5.32e-1)" 9.5 7.6 2.5 14.0 1.9 34.3 9.5 8.0 4.0 11.0 4.1 9.8 9.9 10.8 6.0 10.4 9.2 9.2 6.8 1.6 2.9 8.0 12.3 9.2 15.1 3.0 1.7 11.9 8.7 13.0 6.2 11.5 1.6 9.8 10.4 11.7 9.2 9.3 6.7 10.6 10.4 10.0 0.3 12.9 10.3 17.7 3.4 17.9 12.2 7.8 15.3 13.1 9.1 3.3 31.9 40.0 24.9 22.2 17.2 19.0 21.1 28.9 24.7 39.9 29.0 48.1 19.8 45.4 24.6 31.1 38.7 51.8 49.2 36.6 38.4 29.6 38.7 49.7 26.9 36.3 16.4 66.9 33.4 20.4 25.0 48.2 37.6 16.0 24.4 27.7 85.2 30.7 22.9 14.3 57.9 17.7 23.8 16.0 16.9 36.8 50.3 25.7 14.8 38.8 24.6 15.7 37.0 307.8 25.1 34.8 38.5 29.3 26.4 34.5 27.6 24.5 37.9 23.6 18.4 63.5 24.2 28.2 23.0 11.2 2.0 3.2 2.6 1.5 1.8 1.8 1.5 1.7 1.2 3.1 1.7 1.6 7.0 4.5 1.3 2.7 1.2 0.7 2.5 1.9 8.0 4.0 1.6 2.9 3.0 1.7 1.6 0.3 3.4 3.3 41.4 25.6 29.1 50.9 59.0 64.6 58.5 31.2 50.1 46.6 38.1 26.9 14.5 32.9 40.3 38.6 64.6 33.2 59.0 44.6 13.7 30.2 25.1 49.8 63.4 40.6 31.1 39.3 53.9 27.5 29.9 39.2 45.3 63.1 29.1 43.8 32.2 46.3 27.4 35.3 52.9 39.6 42.7 45.9 49.1 17.3 37.3 41.3 26.6 32.8 41.4 27.8 48.4 47.3 53.1 47.9 33.9 33.8 53.5 81.5 33.3 16.7 38.1 65.4 32.9 48.0 48.5 140.2 104.8 53.0 69.0 58.3 59.0 46.0 39.9 84.8 CDK13 "CDC2L, CDC2L5, CHED, KIAA1791" ENSG00000065883 "Cyclin dependent kinase 13" Q14004 7 39950121-40099580 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Host-virus interaction, mRNA processing, mRNA splicing" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 179.0;Oligodendrocyte precursor cells: 171.9;Oligodendrocytes: 199.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA059241 Uncertain Supported "Nuclear speckles,Golgi apparatus,Cytosol" NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 34: Non-specific - Transcription" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 52: Non-specific - Transcription" "Nuclear speckles" "Golgi apparatus, Cytosol" "HPA059241: AB_2683956" "unprognostic (1.99e-1)" "unprognostic (1.22e-2)" "unprognostic (2.67e-1)" "unprognostic (2.72e-1)" "unprognostic (1.83e-1)" "unprognostic (1.02e-1)" "unprognostic (4.18e-3)" "unprognostic (3.42e-2)" "unprognostic (8.09e-2)" "unprognostic (1.13e-2)" "unprognostic (3.77e-2)" "unprognostic (8.13e-2)" "unprognostic (8.20e-2)" "unprognostic (1.21e-1)" "unprognostic (3.33e-2)" "unprognostic (3.53e-1)" "unprognostic (3.53e-2)" 11.4 10.2 8.8 14.6 10.8 28.1 11.1 19.3 9.9 12.8 6.7 11.9 10.5 13.6 14.2 14.7 15.0 12.7 10.4 8.1 10.7 12.7 15.9 12.1 21.7 10.5 8.5 20.1 12.8 17.2 8.0 13.6 8.6 11.2 13.6 19.7 12.9 11.8 11.2 12.0 12.0 12.0 7.2 16.6 12.3 19.0 10.1 19.6 20.6 14.0 20.2 13.4 10.0 14.9 28.4 16.6 28.2 27.0 24.9 24.1 19.3 22.1 23.8 19.8 24.6 17.8 19.1 51.0 12.6 23.4 34.8 33.6 23.4 19.4 29.0 25.3 17.3 22.8 20.0 16.0 23.7 34.8 23.5 14.3 25.5 22.6 30.0 22.6 23.6 23.1 39.0 34.3 20.7 14.7 28.0 24.9 40.8 20.0 19.1 30.5 18.5 20.5 18.5 28.1 20.0 28.8 27.6 59.8 19.9 36.7 24.6 43.0 28.3 27.0 26.0 17.6 30.5 28.3 26.0 41.2 19.8 30.9 35.4 7.8 2.2 4.0 4.1 1.9 2.8 6.4 3.8 3.0 1.3 10.5 3.8 3.9 5.9 4.3 3.1 3.3 3.9 1.3 8.8 10.8 19.3 9.9 8.1 10.7 10.5 8.5 8.6 7.2 10.1 14.9 47.6 44.8 72.0 131.6 49.7 21.4 18.5 15.9 29.0 47.8 36.7 27.7 30.9 25.8 37.1 31.3 70.9 13.7 91.0 23.1 7.9 20.4 13.9 54.3 51.4 30.9 18.7 5.9 179.0 15.4 9.1 31.7 30.1 72.6 17.1 95.5 19.2 23.7 13.2 37.0 166.2 17.6 14.2 23.8 17.4 9.2 26.1 31.6 14.2 145.2 27.9 22.4 53.5 171.9 199.6 28.6 12.9 17.7 50.1 21.8 15.2 12.7 32.8 69.4 6.6 38.5 32.0 36.1 33.4 34.7 26.1 12.2 49.7 56.8 20.1 25.0 CDK14 "PFTAIRE1, PFTK1" ENSG00000058091 "Cyclin dependent kinase 14" O94921 7 90466424-91210590 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 545.4;Horizontal cells: 173.3;Inhibitory neurons: 426.8;Oligodendrocyte precursor cells: 320.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 8 "basophil: 9.0;memory B-cell: 8.5;naive B-cell: 4.8;neutrophil: 4.8" "Group enriched" "Detected in many" 10 "B-cells: 8.5;granulocytes: 9.0" "Cell line enhanced" "Detected in many" "Karpas-707: 78.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA015267 Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 6: Brain - Smell perception" "Cluster 2: Karpas-707 - Immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Cytosol" "HPA015267: AB_1855249" "prognostic favorable (5.86e-4)" "unprognostic (3.96e-1)" "unprognostic (1.91e-2)" "unprognostic (2.09e-3)" "unprognostic (1.18e-1)" "unprognostic (3.45e-1)" "unprognostic (1.72e-1)" "unprognostic (4.48e-2)" "unprognostic (3.60e-2)" "unprognostic (3.09e-2)" "unprognostic (2.77e-3)" "unprognostic (2.91e-2)" "unprognostic (2.57e-2)" "prognostic unfavorable (7.79e-4)" "unprognostic (2.46e-1)" "unprognostic (2.86e-1)" "unprognostic (4.39e-3)" 10.1 4.4 9.7 7.8 12.8 7.1 8.6 11.6 31.2 10.1 0.0 5.9 2.7 8.5 3.1 3.1 12.2 12.2 11.9 18.5 7.9 20.7 13.4 9.6 12.4 7.8 17.9 14.5 15.1 3.0 9.2 6.1 7.8 11.2 3.3 17.4 8.3 6.7 4.6 2.5 3.8 7.6 6.4 8.2 8.0 7.9 19.2 5.5 13.3 7.2 12.9 5.7 5.2 20.5 18.0 0.2 35.0 4.5 31.9 32.0 8.0 14.7 14.0 8.8 9.5 0.4 8.6 58.9 1.8 14.6 13.1 5.2 1.8 20.7 16.9 0.1 8.3 0.0 11.2 0.4 14.7 18.3 0.3 22.7 5.3 26.5 9.4 14.7 11.6 0.4 0.3 78.4 18.4 0.1 0.1 7.3 21.8 0.1 9.6 49.3 47.4 50.2 4.6 4.9 7.7 21.9 37.3 0.2 0.7 15.4 4.7 9.2 28.4 37.8 48.5 32.1 23.0 43.1 36.3 41.9 14.6 23.8 37.9 9.0 0.3 0.5 0.0 0.6 0.0 8.5 0.0 0.0 0.8 4.8 0.0 0.0 4.8 0.1 0.5 0.1 0.2 0.5 9.7 12.8 11.6 31.2 18.5 7.9 7.8 17.9 7.8 6.4 19.2 20.5 11.0 19.2 5.1 118.2 37.4 0.8 7.7 6.0 2.2 6.9 7.0 8.9 18.3 12.8 9.1 11.0 0.0 0.2 0.2 0.4 7.9 9.8 53.9 1.7 13.4 2.8 1.8 4.0 545.4 6.7 0.1 16.1 4.1 1.5 0.0 11.2 1.4 11.3 3.7 173.3 426.8 0.3 4.1 3.4 4.9 46.4 15.5 7.0 5.4 66.5 1.7 9.4 0.0 320.7 32.9 13.4 1.3 15.8 78.1 12.8 0.1 22.7 3.9 9.7 0.0 6.3 15.9 5.4 6.6 1.2 1.3 0.0 1.9 6.5 0.3 4.2 CDK15 "ALS2CR7, PFTAIRE2, PFTK2" ENSG00000138395 "Cyclin dependent kinase 15" Q96Q40 2 201790461-201895550 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "epididymis: 15.2;ovary: 6.1" "Group enriched" "Detected in some" 13 "Early spermatids: 27.1;granulocytes: 79.1;Late spermatids: 40.3" "Not detected" "Not detected" "Region enriched" "Detected in single" 4 "cerebellum: 2.4" "Group enriched" "Detected in some" 28 "basophil: 1.8;eosinophil: 3.7" "Lineage enriched" "Detected in single" 37 "granulocytes: 3.7" "Cell line enhanced" "Detected in some" "BJ hTERT+: 22.6;BJ hTERT+ SV40 Large T+ RasG12V: 20.7;HBF TERT88: 30.9;HMC-1: 58.4;LHCN-M2: 19.1" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA015786 Uncertain Approved "Nucleoplasm,Golgi apparatus" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 68: Epididymis - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 60: Granulocytes - Receptor signaling" Nucleoplasm "Golgi apparatus" "HPA015786: AB_1844780" "unprognostic (2.51e-1)" "unprognostic (2.73e-1)" "unprognostic (2.84e-2)" "unprognostic (1.30e-2)" "unprognostic (1.42e-1)" "unprognostic (2.94e-1)" "unprognostic (4.79e-2)" "unprognostic (1.07e-1)" "unprognostic (1.52e-1)" "unprognostic (1.52e-2)" "unprognostic (1.64e-2)" "unprognostic (1.80e-2)" "unprognostic (7.38e-2)" "unprognostic (9.99e-5)" "unprognostic (6.31e-2)" "unprognostic (1.48e-2)" "unprognostic (1.05e-2)" 0.7 0.3 0.0 0.2 0.0 0.0 0.8 2.4 0.4 0.8 0.0 0.5 0.3 0.6 15.2 0.6 0.5 1.9 0.2 0.5 0.0 0.3 0.0 1.0 0.1 0.4 0.1 6.1 0.1 0.2 0.3 0.0 0.4 0.7 0.7 0.0 0.3 0.3 0.9 0.6 0.8 0.4 0.1 0.0 0.7 1.9 0.1 0.2 0.1 0.7 0.1 0.8 0.5 0.3 0.3 0.0 0.0 0.0 1.6 2.8 0.0 5.9 22.6 10.2 20.7 0.0 3.0 0.0 0.0 2.3 0.5 0.0 0.0 0.0 30.9 0.0 0.1 1.9 0.0 0.0 0.3 0.1 58.4 3.4 0.0 2.7 1.5 0.4 0.0 0.0 0.0 0.1 19.1 0.0 0.0 0.7 0.1 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.2 0.5 2.5 0.1 0.0 0.0 0.0 0.3 0.0 0.0 1.8 0.0 3.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.4 0.5 0.0 0.4 0.1 0.4 0.1 0.1 0.3 0.1 0.0 1.3 0.3 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 27.1 0.0 0.0 0.1 0.0 0.0 2.4 0.0 0.0 0.8 0.0 0.0 79.1 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.3 40.3 0.3 0.1 3.6 1.0 0.0 0.0 0.0 1.0 0.3 0.0 0.0 0.4 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.3 1.4 0.5 0.2 0.0 0.1 0.0 0.9 0.1 0.0 0.0 CDK16 "FLJ16665, PCTAIRE, PCTAIRE1, PCTGAIRE, PCTK1" ENSG00000102225 "Cyclin dependent kinase 16" Q00536 X 47217860-47229997 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Differentiation, Spermatogenesis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 217.6" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000974, HPA001366, CAB016535" Approved Approved "Plasma membrane,Microtubules,Cytosol" NA NA "Cluster 24: B-cells - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 31: Spermatids - Spermatogenesis" "Microtubules, Cytosol" "Plasma membrane" "CAB016535: AB_785112, HPA000974: AB_2666162, HPA001366: AB_1079584" "unprognostic (2.37e-3)" "unprognostic (6.93e-2)" "unprognostic (2.96e-2)" "unprognostic (1.16e-3)" "unprognostic (8.80e-2)" "unprognostic (2.92e-2)" "prognostic unfavorable (2.02e-6)" "unprognostic (2.85e-1)" "unprognostic (5.59e-2)" "unprognostic (7.62e-3)" "unprognostic (1.20e-1)" "unprognostic (1.09e-1)" "unprognostic (1.46e-1)" "unprognostic (1.59e-2)" "unprognostic (1.83e-1)" "unprognostic (3.89e-3)" "unprognostic (2.55e-1)" 48.2 61.3 59.0 30.4 63.6 65.7 38.6 63.8 75.0 37.9 35.7 41.4 34.2 37.5 19.7 60.7 37.6 23.8 113.3 64.3 46.5 62.7 35.0 41.6 24.3 57.2 52.4 45.3 43.1 50.6 41.7 37.9 54.9 37.2 29.6 33.6 43.9 30.4 217.6 41.9 36.3 37.7 39.6 34.0 39.1 55.2 74.3 29.9 50.3 180.4 26.5 34.2 36.8 60.6 177.6 132.5 124.8 185.0 89.5 76.2 124.2 82.4 100.7 122.3 90.5 150.2 83.3 42.1 51.2 148.1 225.7 97.7 134.3 174.7 81.8 50.9 212.6 46.0 193.8 118.8 115.7 48.7 103.0 95.5 109.6 173.8 207.4 101.7 111.0 43.7 69.6 69.7 108.4 153.1 42.7 111.1 97.9 66.3 141.8 44.9 98.8 74.4 91.7 137.7 105.0 79.4 223.2 169.9 86.5 144.4 152.0 59.3 112.9 81.1 131.4 125.4 99.8 54.6 58.2 41.8 71.4 223.0 93.1 2.6 7.8 7.5 3.7 9.3 4.9 3.4 5.0 6.0 9.7 9.8 4.3 4.6 3.2 5.5 8.4 11.3 5.5 6.1 59.0 63.6 63.8 75.0 64.3 46.5 57.2 52.4 54.9 39.6 74.3 60.6 18.8 0.0 6.1 7.2 20.2 32.5 33.0 30.6 33.6 23.5 38.2 26.8 43.3 21.5 22.1 31.3 4.2 25.7 20.1 67.2 54.8 33.7 26.5 41.2 24.5 21.8 28.1 20.6 12.5 37.0 45.2 24.0 46.4 57.7 5.7 27.8 19.2 16.7 25.3 30.3 15.8 34.3 32.6 19.5 30.8 94.8 17.1 23.5 33.8 2.8 12.6 17.1 9.2 3.5 7.8 48.4 46.1 13.2 31.9 48.3 45.1 34.7 17.9 14.6 0.0 19.1 22.6 27.6 17.5 64.2 34.7 26.0 21.5 30.0 48.6 63.3 CDK17 "PCTAIRE2, PCTK2" ENSG00000059758 "Cyclin dependent kinase 17" Q00537 12 96278261-96400480 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 101.5;Oligodendrocytes: 259.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HUVEC TERT2: 134.8;TIME: 160.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA015325 Approved Approved Nucleoplasm,Cytosol Yes No "Cluster 38: Basophils - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 59: Non-specific - Transcription" "Nucleoplasm, Cytosol" "HPA015325: AB_1855090" "unprognostic (4.35e-1)" "unprognostic (2.79e-1)" "unprognostic (2.70e-1)" "unprognostic (3.56e-1)" "unprognostic (1.50e-1)" "unprognostic (4.96e-3)" "unprognostic (5.22e-3)" "unprognostic (1.23e-1)" "unprognostic (3.23e-2)" "unprognostic (2.75e-2)" "unprognostic (2.44e-1)" "unprognostic (5.96e-2)" "prognostic unfavorable (1.09e-6)" "unprognostic (4.97e-3)" "unprognostic (1.72e-1)" "unprognostic (2.92e-2)" "unprognostic (1.70e-2)" 21.4 11.2 26.3 18.9 45.9 48.1 18.4 23.0 34.7 13.2 8.3 17.0 11.9 26.2 9.1 14.6 13.9 16.2 11.4 36.7 28.6 11.6 16.3 20.6 21.7 23.2 23.0 15.7 10.5 10.6 8.0 31.8 23.0 14.0 12.2 19.3 8.7 11.1 8.8 11.0 11.5 29.5 27.4 21.8 10.5 26.6 28.5 24.8 11.6 12.3 22.2 17.1 12.8 54.0 15.4 12.5 32.5 8.9 15.9 41.2 24.1 34.8 46.9 29.1 27.2 7.7 8.8 22.7 23.0 24.5 15.6 13.8 19.8 20.9 39.5 24.9 15.5 32.7 8.5 10.9 34.4 17.9 18.4 30.0 21.3 43.0 77.1 51.8 134.8 18.9 24.7 18.1 66.8 9.5 17.0 28.1 14.4 7.6 22.8 29.2 18.0 19.8 35.1 12.7 17.1 11.7 19.9 18.4 25.9 24.7 14.0 15.7 160.5 25.6 10.0 13.8 18.7 26.0 21.1 24.1 9.6 7.6 19.2 66.7 6.4 17.1 22.2 9.3 24.0 17.5 17.9 25.1 10.0 16.6 25.0 21.7 23.2 31.4 9.0 7.3 15.8 16.6 26.3 45.9 23.0 34.7 36.7 28.6 23.2 23.0 23.0 27.4 28.5 54.0 58.1 16.0 6.5 54.5 37.3 26.8 10.7 8.6 19.4 11.8 13.8 9.8 11.9 7.2 10.3 9.2 16.7 12.0 64.4 7.2 0.0 4.9 3.3 17.6 10.0 51.7 15.0 17.9 101.5 3.6 27.9 24.0 21.4 17.2 18.3 8.9 34.2 10.8 12.1 5.0 59.2 7.9 4.1 14.5 20.7 4.1 9.9 16.7 17.8 64.6 8.6 22.6 32.0 52.3 259.2 7.4 3.4 9.4 64.7 12.5 6.5 8.6 15.4 9.6 6.6 22.7 22.0 8.8 21.6 24.2 25.9 13.7 63.2 10.7 6.0 15.1 CDK18 "PCTAIRE3, PCTK3" ENSG00000117266 "Cyclin dependent kinase 18" Q07002 1 205504596-205532793 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 179.6;heart muscle: 116.3" "Cell type enriched" "Detected in many" 4 "Oligodendrocytes: 462.9" "Cancer enhanced" "Detected in all" "renal cancer: 32.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HBEC3-KT: 38.5;HeLa: 35.3;hTERT-RPE1: 32.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA045429 Approved Approved "Actin filaments" No No "Cluster 73: Brain - Neuropeptide signaling" "Cluster 20: HeLa - Mitochondria" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Actin filaments" "HPA045429: AB_10961257" "unprognostic (7.95e-2)" "unprognostic (3.42e-1)" "unprognostic (1.51e-1)" "unprognostic (1.33e-1)" "unprognostic (4.38e-2)" "unprognostic (1.30e-1)" "unprognostic (7.06e-3)" "unprognostic (2.93e-1)" "unprognostic (2.95e-1)" "unprognostic (1.13e-1)" "unprognostic (8.89e-2)" "unprognostic (2.81e-1)" "prognostic unfavorable (5.07e-6)" "unprognostic (6.07e-2)" "unprognostic (1.45e-1)" "unprognostic (6.12e-2)" "prognostic favorable (2.81e-5)" 6.1 9.0 68.6 4.1 131.1 1.1 5.1 141.2 82.6 10.9 40.0 13.1 28.8 8.6 3.4 5.7 8.6 10.4 116.3 57.8 90.8 26.5 10.6 11.0 2.8 179.2 148.1 12.6 16.9 7.8 11.5 16.1 147.7 9.2 9.2 13.3 29.2 23.6 6.1 3.3 24.9 7.0 115.2 9.5 35.8 1.6 122.1 3.6 9.5 5.3 3.7 5.7 7.5 179.6 22.2 1.4 0.2 1.3 0.0 0.0 22.6 0.4 4.1 1.0 5.5 9.4 17.8 12.4 3.2 0.2 1.9 21.2 4.9 38.5 0.9 3.4 3.8 3.0 35.3 10.5 4.0 0.1 0.2 2.5 1.9 0.1 0.8 32.2 0.0 18.4 0.1 15.2 0.3 17.7 1.2 0.6 18.4 6.1 0.9 1.6 0.1 16.6 3.6 13.5 7.9 2.8 6.4 3.2 14.2 24.5 15.3 6.2 0.0 0.0 8.1 0.1 0.1 4.1 2.1 2.5 0.2 9.4 3.7 0.0 0.1 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 68.6 131.1 141.2 82.6 57.8 90.8 179.2 148.1 147.7 115.2 122.1 179.6 4.6 0.0 0.5 12.4 1.0 3.4 6.9 17.4 11.4 7.0 4.6 5.6 29.6 5.7 6.8 73.5 0.0 5.7 0.2 12.1 7.9 18.5 2.4 2.1 0.7 2.9 6.0 1.3 12.0 6.7 2.3 3.8 15.8 4.6 0.0 13.3 2.5 3.7 5.3 0.0 4.5 12.9 2.0 3.8 4.5 4.0 0.9 3.8 3.6 12.2 4.4 28.2 1.0 4.5 462.9 6.5 111.2 1.5 0.9 10.8 35.6 18.7 3.3 1.2 6.6 5.8 12.8 6.6 17.0 5.3 1.3 1.9 1.4 22.7 13.7 9.2 CDK19 "bA346C16.3, CDC2L6, CDK11, KIAA1028" ENSG00000155111 "Cyclin dependent kinase 19" Q9BWU1 6 110609978-110815958 "Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 40.8" "Cell type enhanced" "Detected in all" "Late spermatids: 137.1;Oligodendrocyte precursor cells: 154.8;Oligodendrocytes: 476.3" "Cancer enhanced" "Detected in all" "prostate cancer: 23.3" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "neutrophil: 4.6" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007053, HPA007062" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 18: U-2197 - ECM organization" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol Nucleoplasm "HPA007053: AB_1233803, HPA007062: " "unprognostic (1.66e-2)" "unprognostic (1.84e-1)" "unprognostic (3.63e-1)" "unprognostic (3.00e-3)" "unprognostic (1.62e-1)" "unprognostic (2.66e-3)" "prognostic unfavorable (3.56e-4)" "unprognostic (1.47e-2)" "unprognostic (2.96e-2)" "unprognostic (2.00e-3)" "unprognostic (3.94e-1)" "unprognostic (4.04e-1)" "prognostic unfavorable (4.72e-5)" "unprognostic (1.75e-1)" "unprognostic (9.78e-2)" "unprognostic (6.51e-2)" "unprognostic (9.50e-3)" 6.2 3.4 22.7 7.2 32.1 11.7 6.4 17.9 29.0 6.6 7.5 6.9 5.3 10.2 3.8 8.2 5.4 8.3 4.4 20.8 19.3 6.4 5.0 6.7 9.4 28.8 24.7 9.8 3.9 6.5 2.3 11.5 22.7 26.7 6.4 8.8 4.4 5.9 3.3 8.5 6.7 7.3 19.4 8.0 7.1 18.5 26.9 13.6 6.1 5.4 9.2 5.3 6.6 40.8 5.7 6.1 21.8 26.4 11.1 15.6 10.8 18.8 19.4 6.7 8.8 7.6 6.4 14.7 6.5 13.2 13.9 3.2 8.0 3.9 15.4 18.2 4.5 26.0 8.8 8.9 6.8 10.5 18.2 10.7 8.6 9.7 14.1 17.0 6.8 12.3 7.6 20.2 14.5 9.7 14.3 15.0 2.0 8.1 4.1 14.8 11.3 5.8 7.8 11.0 10.6 19.8 14.4 11.3 17.0 7.2 3.9 37.1 7.7 14.2 7.6 29.6 11.4 2.1 3.2 12.8 15.6 13.7 14.9 2.1 1.2 0.9 0.4 0.7 0.4 0.6 0.3 0.3 1.0 0.6 0.2 0.3 4.6 0.7 0.4 0.5 0.4 0.3 22.7 32.1 17.9 29.0 20.8 19.3 28.8 24.7 22.7 19.4 26.9 40.8 15.9 3.2 17.8 50.6 19.2 9.8 14.4 6.7 12.0 19.2 14.6 9.4 8.2 18.6 8.7 16.5 16.7 7.0 17.8 27.0 1.9 10.5 102.3 13.7 16.5 13.6 12.6 21.6 85.3 4.7 18.4 12.0 13.7 25.6 7.0 23.0 20.0 12.2 16.4 23.5 51.5 13.5 8.2 33.9 19.9 137.1 10.8 22.1 26.6 62.8 19.6 33.9 22.6 154.8 476.3 7.0 20.0 16.1 5.9 30.0 16.1 7.7 6.9 13.9 6.6 11.2 12.3 56.6 15.8 20.3 16.2 7.9 13.3 10.1 13.8 11.1 CDK2 ENSG00000123374 "Cyclin dependent kinase 2" P24941 12 55966781-55972789 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, DNA damage, DNA repair, Meiosis, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 92.8;Extravillous trophoblasts: 84.7;Melanocytes: 87.2;Syncytiotrophoblasts: 170.7" "Cancer enhanced" "Detected in all" "melanoma: 88.3" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "SK-MEL-30: 540.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB013115, HPA066915" Enhanced Enhanced Nucleoplasm,Centrosome,Cytosol NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 28: Placenta - Pregnancy" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" Nucleoplasm "Centrosome, Cytosol" "CAB013115: AB_2536375, HPA066915: AB_2685748" "unprognostic (2.36e-2)" "unprognostic (2.60e-1)" "unprognostic (3.71e-2)" "unprognostic (1.83e-2)" "unprognostic (1.75e-1)" "prognostic unfavorable (9.94e-4)" "prognostic unfavorable (8.61e-5)" "unprognostic (3.48e-2)" "unprognostic (1.31e-1)" "unprognostic (4.67e-2)" "unprognostic (5.38e-3)" "unprognostic (4.69e-3)" "prognostic unfavorable (1.46e-10)" "unprognostic (1.05e-1)" "unprognostic (1.76e-1)" "unprognostic (6.16e-2)" "unprognostic (6.75e-2)" 15.3 9.2 3.5 16.3 3.4 36.0 14.2 3.6 4.9 13.4 6.4 12.5 9.8 13.7 6.3 14.9 13.7 10.8 10.9 3.5 3.8 14.7 16.2 22.9 21.6 4.7 4.0 16.3 10.0 7.9 4.9 47.3 4.1 12.6 14.9 6.5 10.9 14.3 7.0 22.7 12.3 19.5 4.2 14.5 12.2 6.6 4.1 37.2 9.6 8.1 24.8 18.1 12.9 3.9 81.7 39.1 93.6 52.4 19.2 24.9 172.2 98.9 53.5 123.3 114.8 89.4 76.3 77.5 70.9 37.9 46.4 50.8 73.4 44.9 126.8 86.9 68.0 89.0 65.0 34.6 6.3 70.4 61.4 12.6 10.9 83.8 29.1 36.1 63.1 76.8 85.6 68.0 88.3 60.8 149.9 61.7 36.9 55.8 60.7 143.7 86.2 57.1 36.5 77.1 37.4 48.1 114.1 41.7 540.3 54.9 88.9 51.1 34.5 82.9 76.3 65.0 71.0 37.4 46.3 95.5 47.4 51.1 74.2 3.6 2.6 2.2 4.7 2.7 4.6 6.5 2.1 3.5 1.9 3.7 2.0 3.7 1.2 3.4 1.2 7.9 5.4 3.3 3.5 3.4 3.6 4.9 3.5 3.8 4.7 4.0 4.1 4.2 4.1 3.9 17.9 16.0 4.8 1.3 7.3 28.0 23.9 6.2 12.5 0.0 14.5 8.9 3.1 11.5 7.6 1.8 0.0 92.8 7.1 3.7 1.9 11.5 0.6 7.4 6.5 18.2 5.4 14.7 0.1 5.7 84.7 15.7 9.2 13.0 10.8 12.0 10.4 9.1 13.3 1.7 0.1 7.2 6.1 4.7 43.8 0.8 14.9 4.9 87.2 1.9 28.4 4.2 5.2 0.0 0.5 12.3 1.5 4.5 11.8 13.4 2.8 4.5 4.4 3.6 0.0 10.1 11.6 3.1 7.4 14.5 31.4 170.7 9.6 4.8 9.7 19.3 CDK20 "CCRK, p42" ENSG00000156345 "Cyclin dependent kinase 20" Q8IZL9 9 87966441-87974753 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Respiratory ciliated cells: 21.9;Spermatocytes: 30.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "NK-cell: 3.6" "Group enriched" "Detected in many" 7 "NK-cells: 3.6;T-cells: 2.3" "Cell line enhanced" "Detected in many" "SCLC-21H: 18.2;THP-1: 29.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA007666, HPA027379, HPA027401" Enhanced Supported Nucleoplasm NA NA "Cluster 15: NK-cells - Transcription" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 43: THP-1 - Innate immune response" "Cluster 49: Ciliated cells - Cilium organization" Nucleoplasm "HPA007666: AB_10600002, HPA027379: AB_10599939, HPA027401: AB_10601553" "unprognostic (4.60e-2)" "unprognostic (6.48e-2)" "unprognostic (1.69e-2)" "prognostic favorable (2.59e-4)" "unprognostic (2.32e-1)" "unprognostic (4.33e-3)" "unprognostic (2.81e-4)" "unprognostic (6.33e-2)" "unprognostic (1.45e-1)" "unprognostic (1.34e-1)" "unprognostic (2.83e-3)" "unprognostic (4.04e-2)" "prognostic favorable (2.12e-5)" "unprognostic (8.24e-3)" "unprognostic (5.77e-2)" "unprognostic (3.83e-2)" "unprognostic (1.42e-2)" 2.9 14.8 8.8 1.5 9.8 1.0 3.1 5.5 9.5 7.2 11.1 6.4 3.5 5.7 3.8 2.3 13.3 3.5 3.4 10.0 10.6 8.3 3.3 3.0 1.2 6.4 6.8 7.8 6.1 8.4 12.7 1.8 6.9 5.2 2.2 8.4 3.3 5.5 1.0 3.3 4.8 3.6 6.1 1.4 4.4 15.9 10.9 1.3 5.3 1.3 0.5 7.6 3.7 7.1 3.1 3.6 3.2 9.5 2.6 3.5 1.2 2.7 5.4 7.7 6.9 1.1 4.6 0.0 3.7 4.6 13.0 3.7 0.0 2.8 3.2 7.3 3.2 0.0 1.9 0.0 9.2 3.7 4.4 2.6 5.5 12.0 5.1 5.9 0.0 6.7 0.4 0.0 2.2 9.1 2.2 1.2 2.4 7.2 1.1 0.0 0.0 0.1 9.6 2.8 18.2 5.2 2.9 3.9 4.9 1.1 3.9 29.8 0.0 3.4 1.3 0.6 3.0 4.2 4.6 0.0 11.7 2.4 3.5 0.0 0.3 0.2 0.6 0.4 0.3 0.0 1.4 1.0 0.3 0.0 2.3 1.6 0.0 3.6 0.3 0.3 1.5 0.6 8.8 9.8 5.5 9.5 10.0 10.6 6.4 6.8 6.9 6.1 10.9 7.1 0.3 3.2 4.4 5.2 0.2 2.2 2.3 2.2 5.7 6.1 3.0 3.2 2.0 2.8 4.0 1.8 2.1 4.6 0.8 5.8 1.9 5.2 6.3 15.8 6.7 0.8 0.0 0.8 8.3 1.5 2.3 3.4 4.1 5.8 1.3 4.0 0.7 0.8 0.9 8.4 6.7 2.8 4.1 0.0 0.2 4.3 4.4 1.1 0.0 1.0 0.3 5.0 2.1 3.0 2.9 1.4 1.6 6.8 0.3 3.0 7.3 6.3 21.9 15.0 6.6 1.1 3.2 30.2 3.4 0.8 2.3 4.0 1.1 11.6 3.4 1.2 CDK3 ENSG00000250506 "Cyclin dependent kinase 3" Q00526 17 76000906-76005999 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Breast glandular cells: 5.3;Breast myoepithelial cells: 5.0;Glandular and luminal cells: 5.2;Granulosa cells: 6.3;Ionocytes: 10.2" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in many" HPA007420 Uncertain Approved Cytosol NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 18: Non-specific - Mitochondria" "Cluster 24: NB-4 - Immune response" "Cluster 7: Non-specific - Mitochondria" Cytosol "HPA007420: AB_1078490" "unprognostic (6.77e-2)" "unprognostic (1.26e-1)" "unprognostic (3.69e-2)" "unprognostic (1.87e-3)" "unprognostic (6.41e-2)" "unprognostic (1.10e-3)" "unprognostic (1.61e-2)" "unprognostic (1.56e-1)" "unprognostic (8.12e-3)" "unprognostic (1.34e-1)" "unprognostic (9.80e-5)" "unprognostic (1.19e-2)" "unprognostic (6.75e-7)" "unprognostic (4.25e-2)" "unprognostic (1.63e-2)" "unprognostic (4.68e-1)" "unprognostic (4.47e-4)" 12.7 11.0 11.4 7.7 11.8 10.6 12.2 11.5 13.8 15.7 12.0 14.9 10.4 11.5 10.7 11.1 13.7 10.3 8.4 11.3 12.2 18.4 34.8 14.2 10.5 12.0 11.7 15.9 15.1 4.8 19.7 8.9 12.2 25.7 10.1 6.9 13.6 8.4 3.6 24.7 14.7 7.6 11.5 21.9 12.2 15.6 11.8 5.8 19.5 3.3 10.5 10.8 13.3 13.6 5.5 7.5 13.5 6.5 7.3 9.0 26.1 4.6 4.6 8.0 7.4 7.0 11.0 6.5 4.5 5.7 4.6 11.6 10.2 4.1 5.6 3.3 14.1 12.7 17.8 7.3 6.7 5.9 14.9 8.7 10.8 7.3 5.1 13.0 6.9 4.1 5.6 4.5 4.3 12.1 6.3 21.8 6.3 3.8 8.4 10.4 5.2 7.2 6.9 15.8 8.4 22.0 3.8 12.0 3.2 14.2 17.4 10.9 5.5 16.4 9.6 5.4 6.7 9.9 7.2 6.2 5.4 5.5 3.9 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.5 0.1 11.4 11.8 11.5 13.8 11.3 12.2 12.0 11.7 12.2 11.5 11.8 13.6 4.3 0.0 0.0 0.0 0.5 2.7 0.0 4.0 0.0 0.0 5.3 5.0 0.3 0.0 2.2 0.0 0.0 0.0 3.1 0.0 1.9 2.0 0.0 2.9 3.9 1.4 0.0 0.0 0.0 2.3 0.0 1.3 0.0 5.2 0.0 6.3 0.0 0.0 0.0 0.0 0.0 0.0 10.2 0.0 4.4 0.0 0.0 1.4 3.6 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.5 0.0 0.0 1.2 2.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 2.7 0.0 1.0 2.8 0.0 0.0 CDK4 PSK-J3 ENSG00000135446 "Cyclin dependent kinase 4" P11802 12 57747727-57756013 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Cancer enriched" "Detected in all" 5 "glioma: 175.8" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Group enriched" "Detected in all" 10 "HBEC3-KT: 2594.8;LHCN-M2: 2819.4;RH-30: 8902.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006024, CAB013116, CAB069405" Supported Supported "Nucleoplasm,Nuclear membrane,Nucleoli,Cytosol" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 89: Fibroblasts - ECM organization" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 39: Non-specific - Basic cellular processes" Cytosol "Nucleoplasm, Nuclear membrane, Nucleoli" "CAB013116: AB_2536376, CAB069405: AB_1613464, HPA006024: AB_2667497" "unprognostic (8.88e-2)" "unprognostic (2.53e-1)" "unprognostic (5.27e-2)" "unprognostic (9.01e-2)" "unprognostic (2.21e-1)" "unprognostic (1.10e-1)" "prognostic unfavorable (2.09e-7)" "unprognostic (7.39e-2)" "unprognostic (3.23e-3)" "unprognostic (2.93e-2)" "unprognostic (3.19e-2)" "unprognostic (9.10e-2)" "prognostic unfavorable (3.15e-5)" "unprognostic (3.32e-1)" "unprognostic (1.67e-1)" "unprognostic (3.64e-1)" "unprognostic (1.57e-2)" 69.7 87.8 35.0 52.8 37.9 72.0 76.6 37.7 36.9 84.3 35.9 62.6 40.2 97.4 64.2 57.2 69.4 57.1 58.9 33.6 37.1 58.5 51.5 58.0 66.8 37.1 36.9 97.3 70.9 63.5 67.7 52.4 36.8 52.7 63.3 14.5 54.4 54.1 48.2 58.9 47.2 80.4 37.3 51.5 54.8 24.1 37.3 67.6 66.0 52.7 70.6 71.6 60.7 37.6 207.1 235.7 295.7 268.0 253.7 220.7 210.4 116.1 347.9 468.5 385.7 338.2 189.1 297.4 200.2 173.6 293.2 158.0 396.3 2594.8 354.9 150.9 209.0 275.4 149.5 237.9 297.0 309.7 182.5 221.5 180.9 294.2 326.7 326.4 304.8 280.0 301.3 242.7 2819.4 304.9 296.7 256.5 347.0 208.0 249.8 267.3 8902.5 272.1 147.2 320.6 271.2 251.7 205.3 150.2 310.0 195.1 202.8 380.7 146.1 233.6 217.0 265.8 233.1 122.2 206.1 450.8 214.1 291.3 286.9 9.5 46.5 10.3 79.6 65.6 81.8 93.5 70.0 72.5 66.7 90.0 93.0 84.4 4.4 56.6 41.9 84.9 57.0 73.6 35.0 37.9 37.7 36.9 33.6 37.1 37.1 36.9 36.8 37.3 37.3 37.6 47.1 22.4 30.8 7.8 40.0 89.7 78.6 83.4 74.0 15.9 67.2 82.2 0.7 51.5 35.3 47.8 10.4 82.9 26.1 15.9 70.5 93.1 13.5 14.9 77.7 50.8 45.6 98.0 5.2 62.5 134.5 79.4 28.5 22.6 69.1 60.2 39.7 35.8 132.9 18.5 6.7 42.2 40.7 25.1 44.1 8.0 64.0 31.2 53.4 6.5 41.9 51.4 29.9 5.5 8.0 48.3 18.9 63.2 57.8 113.9 14.0 80.9 7.4 17.9 32.9 62.1 61.9 32.1 48.3 74.5 86.1 46.8 32.3 78.8 78.7 49.4 CDK5 PSSALRE ENSG00000164885 "Cyclin dependent kinase 5" Q00535 7 151053815-151057897 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Biological rhythms, Cell cycle, Cell division, Neurogenesis" "Kinase, Serine/threonine-protein kinase, Transferase" "Lissencephaly, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 65.8" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008909, HPA064535" Enhanced Supported "Nucleoplasm,Plasma membrane,Cell Junctions" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 65: Brain - Ion transport" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 10: Non-specific - Unknown function" "Nucleoplasm, Plasma membrane" "Cell Junctions" "CAB008909: , HPA064535: AB_2685280" "unprognostic (1.21e-1)" "unprognostic (3.23e-2)" "unprognostic (4.22e-2)" "unprognostic (1.43e-1)" "unprognostic (1.10e-1)" "unprognostic (3.48e-1)" "unprognostic (5.67e-3)" "unprognostic (1.05e-2)" "unprognostic (1.22e-1)" "unprognostic (5.78e-3)" "unprognostic (6.25e-3)" "unprognostic (3.35e-1)" "unprognostic (4.47e-2)" "unprognostic (1.46e-2)" "unprognostic (1.77e-1)" "unprognostic (2.88e-1)" "unprognostic (1.11e-1)" 6.3 16.8 50.2 9.4 53.2 11.2 8.6 44.9 65.8 8.6 40.0 9.3 10.9 6.7 24.9 10.2 8.2 9.5 9.8 57.5 50.9 13.5 12.5 8.3 9.8 48.6 45.3 4.5 9.5 22.8 14.7 8.6 48.4 8.8 9.9 11.3 9.6 10.2 8.5 9.5 8.6 10.4 43.2 9.4 7.9 4.9 50.1 14.2 10.0 7.2 11.6 8.8 6.0 50.9 31.9 40.8 37.3 59.7 48.8 36.1 17.8 24.4 41.7 47.9 40.3 31.2 31.0 34.7 71.3 31.8 63.5 23.5 67.8 40.6 22.6 24.9 43.3 38.2 32.4 30.7 31.6 29.0 64.4 37.9 28.7 39.0 13.5 62.8 38.8 57.6 36.3 24.0 50.7 68.4 76.4 57.9 39.3 57.2 80.5 38.9 14.8 41.5 46.2 27.9 23.0 97.8 30.9 37.7 43.8 36.0 18.6 25.9 22.7 42.2 10.3 31.2 39.2 52.1 61.4 13.7 66.4 46.5 75.8 18.9 39.4 20.1 13.5 46.2 11.1 13.3 12.8 13.6 44.7 12.8 9.8 11.8 5.7 19.9 36.4 26.9 31.9 23.8 50.2 53.2 44.9 65.8 57.5 50.9 48.6 45.3 48.4 43.2 50.1 50.9 7.6 0.0 6.0 1.6 6.2 3.6 8.2 18.0 6.2 12.1 9.6 10.4 3.1 8.6 14.7 11.0 2.1 26.8 5.4 8.0 39.2 21.4 0.8 14.9 10.9 8.9 9.0 12.2 5.8 18.9 12.3 7.6 9.7 9.3 30.5 23.6 7.9 11.1 41.9 0.0 6.4 8.9 18.3 21.9 6.2 1.3 4.7 16.6 10.6 1.9 19.9 12.6 12.3 1.5 3.7 22.8 15.0 11.3 12.4 4.3 20.2 35.7 14.4 7.1 6.6 4.5 13.1 3.9 11.2 11.4 6.3 9.0 7.3 14.2 9.5 9.0 CDK5RAP1 "C20orf34, C42, CGI-05, HSPC167" ENSG00000101391 "CDK5 regulatory subunit associated protein 1" Q96SZ6 20 33358839-33401561 "Enzymes, Predicted intracellular proteins" "tRNA processing" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Ionocytes: 128.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "CACO-2: 116.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA066301 Approved "Nuclear speckles,Mitochondria" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 39: CACO-2 - Unknown function" "Cluster 24: Non-specific - Transcription regulation" "Nuclear speckles" Mitochondria "HPA066301: AB_2685653" "unprognostic (2.86e-1)" "unprognostic (7.19e-2)" "unprognostic (1.31e-1)" "unprognostic (1.66e-3)" "unprognostic (2.25e-1)" "unprognostic (6.49e-2)" "unprognostic (7.68e-3)" "unprognostic (2.18e-2)" "unprognostic (5.10e-1)" "unprognostic (2.36e-1)" "unprognostic (5.90e-3)" "prognostic unfavorable (8.07e-4)" "unprognostic (3.51e-2)" "unprognostic (8.13e-2)" "unprognostic (1.28e-1)" "unprognostic (4.87e-1)" "unprognostic (1.06e-1)" 9.1 8.4 4.9 10.7 5.7 18.6 10.5 4.9 5.3 8.4 6.3 9.0 8.9 9.8 11.5 9.3 9.2 6.2 12.0 5.7 4.3 9.0 11.1 9.0 12.7 4.5 4.4 8.6 7.6 11.2 7.2 10.3 4.1 8.4 12.2 15.9 10.6 8.7 20.9 12.6 9.5 10.8 3.9 10.3 9.7 9.3 4.6 11.3 11.9 22.8 15.2 8.7 7.9 4.9 27.0 27.6 18.6 17.1 17.4 13.4 40.7 15.8 22.5 45.0 46.9 116.5 23.9 47.3 21.0 17.2 29.0 39.1 31.8 45.1 34.8 8.9 17.3 57.1 30.8 45.1 20.3 36.6 17.4 17.5 18.9 30.2 35.9 11.4 24.9 13.6 36.7 19.3 20.0 26.6 37.8 27.5 14.1 30.2 40.1 27.8 42.4 36.1 24.5 23.6 25.2 14.3 50.5 24.4 33.0 20.9 34.7 17.4 18.4 33.3 27.3 23.1 27.4 16.6 20.1 34.8 19.8 39.3 15.9 4.5 17.3 11.8 18.5 22.3 22.2 21.4 18.3 18.0 19.1 14.1 16.2 14.0 0.9 21.6 18.4 13.4 17.3 15.1 4.9 5.7 4.9 5.3 5.7 4.3 4.5 4.4 4.1 3.9 4.6 4.9 13.2 16.0 20.0 26.8 18.6 12.1 10.3 21.1 10.8 25.6 9.3 8.9 15.7 11.5 18.6 7.3 27.1 31.4 18.2 7.4 13.7 17.6 2.9 10.1 10.3 11.4 12.6 12.2 36.7 18.3 18.5 10.4 13.3 14.6 29.8 15.6 6.1 15.6 17.5 11.8 25.4 8.6 128.1 10.1 12.6 2.8 13.1 13.5 10.6 10.3 15.2 16.5 19.6 16.1 26.6 13.0 9.0 10.5 19.3 8.3 13.8 15.3 20.9 39.9 19.7 14.8 15.3 32.6 23.6 8.5 10.4 16.0 22.3 16.1 12.6 8.9 CDK6 PLSTIRE ENSG00000105810 "Cyclin dependent kinase 6" Q00534 7 92604921-92836573 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Differentiation" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, FDA approved drug targets, Primary microcephaly" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 41.1" "Cell type enhanced" "Detected in many" "Early spermatids: 215.9;Erythroid cells: 213.5;Late spermatids: 237.0;Oligodendrocytes: 235.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "MOLT-4: 378.4;REH: 173.7" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA002637, CAB004363" Enhanced Supported Nucleoplasm,Cytosol NA NA 26000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 34: Spermatids - Unknown function" Nucleoplasm Cytosol "CAB004363: AB_627242, HPA002637: AB_1846432" "unprognostic (1.29e-1)" "unprognostic (5.98e-3)" "unprognostic (9.07e-2)" "unprognostic (2.78e-3)" "unprognostic (2.56e-2)" "unprognostic (3.24e-2)" "unprognostic (3.39e-1)" "unprognostic (2.42e-3)" "unprognostic (7.19e-2)" "unprognostic (7.78e-3)" "prognostic unfavorable (3.86e-6)" "unprognostic (4.06e-2)" "unprognostic (4.09e-3)" "unprognostic (1.09e-1)" "unprognostic (7.88e-2)" "unprognostic (1.93e-1)" "prognostic unfavorable (2.33e-5)" 3.7 7.3 6.7 4.7 7.1 18.1 4.9 5.4 5.1 4.8 2.6 5.9 6.1 3.1 2.1 4.2 2.9 3.6 4.7 4.0 5.0 4.4 5.9 4.1 6.6 6.3 6.7 2.7 6.2 9.9 1.7 17.3 6.3 3.0 7.5 0.5 5.7 4.2 1.0 6.8 7.2 3.2 5.8 4.9 9.1 3.3 9.6 41.1 2.4 2.3 6.2 3.8 4.6 8.8 27.1 11.3 34.9 23.9 10.6 11.5 5.8 27.2 18.4 14.3 13.5 34.7 20.9 21.7 14.4 19.9 8.4 15.8 20.8 42.6 34.4 43.0 10.6 50.8 23.3 34.7 6.3 33.0 2.7 11.5 23.1 17.9 90.8 13.4 5.6 75.1 49.3 55.5 26.7 5.9 378.4 3.8 9.8 37.4 9.1 173.7 112.0 36.4 20.3 0.7 18.1 113.8 3.7 9.8 17.1 26.0 0.6 54.9 19.3 44.1 63.7 18.0 54.2 27.4 0.5 27.6 6.9 112.1 60.8 0.9 0.2 0.6 0.6 0.4 0.9 0.2 0.6 0.8 0.5 0.3 0.7 0.7 0.1 0.7 0.4 0.9 0.3 0.3 6.7 7.1 5.4 5.1 4.0 5.0 6.3 6.7 6.3 5.8 9.6 8.8 38.6 25.6 3.7 2.9 17.7 60.3 23.5 55.0 62.6 0.4 20.7 21.2 18.1 22.8 32.8 22.0 0.0 53.8 30.5 12.1 9.8 37.0 215.9 3.1 29.0 30.7 16.8 213.5 114.7 23.3 5.3 28.5 42.3 6.9 25.3 39.2 11.4 27.0 16.0 0.0 60.3 63.7 28.5 23.0 48.6 237.0 5.0 27.6 19.6 108.7 22.4 0.8 39.1 119.6 235.3 94.7 22.8 3.4 85.3 47.1 20.1 8.2 11.9 0.0 6.6 100.8 32.2 2.7 33.6 36.7 50.4 17.6 42.5 62.8 92.7 27.3 CDK7 "CAK, CAK1, CDKN7, MO15, STK1" ENSG00000134058 "Cyclin dependent kinase 7" P50613 5 69234795-69277430 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, DNA damage, DNA repair, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 121.0;Extravillous trophoblasts: 343.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BEWO: 169.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004364, HPA007932, HPA008453, CAB079975" Enhanced Supported "Nucleoplasm,Nucleoli fibrillar center,Plasma membrane,Cytosol" NA NA "Cluster 24: B-cells - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 28: BEWO - Transcription regulation" "Cluster 38: Extravillous trophoblasts - Unknown function" Nucleoplasm "Nucleoli fibrillar center, Plasma membrane, Cytosol" "CAB004364: AB_627243, CAB079975: , HPA007932: AB_1078492, HPA008453: " "unprognostic (3.12e-2)" "unprognostic (1.23e-1)" "unprognostic (4.87e-2)" "unprognostic (4.53e-2)" "unprognostic (3.29e-2)" "unprognostic (4.64e-2)" "unprognostic (2.49e-3)" "unprognostic (1.64e-2)" "unprognostic (7.77e-3)" "unprognostic (1.81e-2)" "prognostic unfavorable (3.09e-4)" "unprognostic (3.40e-2)" "prognostic unfavorable (9.42e-7)" "unprognostic (2.61e-1)" "unprognostic (2.38e-1)" "unprognostic (3.86e-2)" "unprognostic (1.55e-2)" 13.4 19.8 9.4 9.5 10.2 29.1 14.8 10.9 12.9 17.5 11.5 13.7 13.3 12.1 12.9 37.3 12.5 6.4 12.4 9.5 10.5 18.4 13.6 12.7 4.8 9.7 9.7 11.7 14.1 3.2 18.2 16.2 9.8 13.7 7.4 12.8 18.9 4.8 26.8 25.3 12.2 7.7 9.8 12.6 13.5 30.6 10.0 9.3 13.2 15.0 13.3 16.1 19.9 9.4 42.8 5.9 19.4 30.6 6.4 24.4 169.5 30.9 37.5 46.2 42.9 62.2 64.5 3.7 36.4 36.8 34.2 65.3 10.8 31.3 40.6 9.0 3.1 8.6 21.4 25.9 32.8 17.9 33.8 7.1 61.3 1.8 46.0 24.5 32.5 22.3 16.3 16.1 13.3 33.3 9.4 51.7 20.7 2.8 25.4 12.3 0.7 27.1 42.6 25.4 8.6 17.5 11.6 50.4 42.4 28.1 44.9 39.3 7.4 17.1 27.4 33.1 18.2 14.4 30.4 16.5 31.4 10.2 15.5 27.9 7.9 16.2 5.3 8.9 7.9 10.6 7.8 10.6 7.3 14.5 5.9 6.4 8.2 8.6 4.7 8.9 10.5 6.1 9.4 10.2 10.9 12.9 9.5 10.5 9.7 9.7 9.8 9.8 10.0 9.4 12.2 16.0 13.2 10.7 7.8 57.7 21.4 32.9 15.4 6.4 12.3 14.7 11.3 10.0 20.2 5.5 12.5 121.0 11.7 10.2 15.6 27.8 26.8 33.1 10.7 11.6 3.0 9.9 17.6 21.6 343.6 13.0 9.7 27.2 15.8 7.4 7.1 6.7 24.0 1.7 13.7 12.3 20.3 8.5 6.0 7.9 7.5 8.5 7.2 11.2 11.6 10.4 15.5 8.0 11.9 29.3 16.2 7.2 5.8 28.2 12.3 29.3 42.4 8.7 26.3 10.0 12.5 70.1 18.6 15.9 41.9 64.6 11.4 6.8 13.2 29.8 CDK8 K35 ENSG00000132964 "Cyclin dependent kinase 8" P49336 13 26254104-26405238 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Transcription, Transcription regulation" "Activator, Kinase, Repressor, Serine/threonine-protein kinase, Transferase" "Autism spectrum disorder, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 118.7;Inhibitory neurons: 175.4;Late spermatids: 100.4;Oligodendrocyte precursor cells: 149.3;Oligodendrocytes: 91.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044721 Approved Nucleoplasm NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 45: Intestine - Brush border" "Cluster 1: K-562 - Erythropoiesis" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "HPA044721: AB_2679059" "unprognostic (3.28e-3)" "unprognostic (2.25e-3)" "unprognostic (2.08e-1)" "unprognostic (3.88e-3)" "unprognostic (2.30e-2)" "unprognostic (1.05e-2)" "unprognostic (6.42e-3)" "unprognostic (1.85e-2)" "unprognostic (5.00e-2)" "unprognostic (8.57e-2)" "unprognostic (2.52e-1)" "unprognostic (3.18e-3)" "unprognostic (2.12e-1)" "prognostic favorable (9.23e-4)" "unprognostic (1.43e-2)" "unprognostic (1.88e-1)" "unprognostic (6.37e-2)" 4.4 2.9 2.2 3.5 2.5 3.2 3.0 7.6 3.0 2.9 1.2 10.5 7.7 4.0 3.2 5.1 2.5 3.9 4.1 3.0 2.7 5.1 5.7 2.9 3.1 2.7 3.0 2.5 7.1 5.1 2.1 5.9 2.4 3.5 6.0 8.5 4.6 6.9 5.0 3.1 7.5 6.6 2.1 2.5 5.0 9.7 2.6 5.9 3.4 5.2 4.1 6.2 2.5 2.1 10.1 8.4 16.5 16.4 8.3 10.2 10.3 19.6 13.2 13.8 10.0 23.8 13.6 10.7 8.3 9.8 11.6 12.2 18.7 12.9 17.2 25.8 10.3 20.5 6.4 8.2 5.8 32.3 11.4 7.5 12.2 10.7 17.3 7.8 10.2 18.1 32.1 0.0 12.5 10.7 25.2 15.1 13.2 15.5 9.9 15.4 15.9 7.6 8.2 9.2 13.6 8.6 8.1 15.1 13.9 12.7 5.5 14.6 10.5 8.8 11.3 16.1 10.4 7.8 15.2 19.3 5.5 13.2 10.7 0.1 0.2 1.0 0.2 0.4 0.4 0.2 0.3 0.4 0.4 0.4 0.4 0.3 0.0 0.2 0.3 0.2 0.2 0.2 2.2 2.5 7.6 3.0 3.0 2.7 2.7 3.0 2.4 2.1 2.6 2.1 6.5 9.6 4.4 63.6 11.2 19.8 7.7 5.9 8.6 20.5 6.4 5.0 5.9 10.0 6.8 1.8 25.0 8.2 9.5 11.7 9.8 8.9 66.4 7.8 7.7 6.6 8.4 9.9 118.7 8.2 9.7 9.4 14.3 7.4 0.0 8.9 6.8 8.0 8.0 18.5 175.4 7.6 10.2 9.1 11.3 100.4 7.8 7.9 8.8 58.1 8.4 7.7 6.2 149.3 91.9 11.5 10.9 8.2 14.4 14.9 18.0 15.3 5.3 17.3 6.6 67.6 10.9 32.9 18.3 12.8 23.9 9.7 10.8 11.2 11.7 16.2 CDK9 "C-2k, CDC2L4, PITALRE, TAK" ENSG00000136807 "Cyclin dependent kinase 9" P50750 9 127785679-127790792 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004216, HPA006738" Supported Approved "Nucleoplasm,Cytoplasmic bodies" NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 29: U-266 - Adaptive immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Nucleoplasm "Cytoplasmic bodies" "CAB004216: AB_627245, HPA006738: AB_1078493" "unprognostic (3.60e-1)" "unprognostic (1.71e-1)" "unprognostic (5.44e-3)" "unprognostic (1.04e-3)" "unprognostic (1.93e-1)" "unprognostic (3.97e-2)" "unprognostic (2.07e-1)" "unprognostic (5.84e-2)" "unprognostic (2.66e-1)" "unprognostic (8.36e-2)" "unprognostic (1.24e-3)" "unprognostic (3.11e-2)" "prognostic unfavorable (8.92e-4)" "unprognostic (1.37e-1)" "unprognostic (1.00e-1)" "unprognostic (3.52e-2)" "unprognostic (8.78e-3)" 44.6 60.8 44.3 23.7 43.7 47.0 40.3 40.8 53.8 55.5 35.4 49.3 19.7 49.3 21.1 35.4 65.6 23.7 40.4 50.8 42.0 44.5 65.1 47.2 35.1 44.7 44.1 88.5 44.4 19.2 67.0 18.7 41.1 44.1 12.2 11.1 29.7 23.3 28.3 38.7 40.9 19.1 42.7 65.6 37.4 44.3 42.1 31.9 42.1 17.1 20.9 38.9 40.5 44.4 22.5 40.5 24.9 27.6 27.6 21.4 32.1 22.9 33.3 23.4 20.9 30.3 25.0 39.5 25.7 26.0 32.1 44.2 16.5 37.3 8.9 34.8 19.0 37.1 45.2 25.3 40.2 36.3 56.5 37.9 44.5 24.8 27.7 30.0 48.5 34.8 32.6 51.7 21.2 60.1 39.5 54.5 55.0 34.3 41.9 112.2 21.2 57.0 34.2 24.9 24.5 29.2 34.5 35.8 20.9 19.3 45.0 33.9 56.4 27.8 30.9 24.1 22.3 92.5 76.4 34.7 26.1 24.4 25.9 4.1 3.7 5.8 10.3 5.1 10.1 3.6 5.7 8.3 4.8 6.6 6.3 7.9 5.4 22.4 7.5 9.9 4.4 3.6 44.3 43.7 40.8 53.8 50.8 42.0 44.7 44.1 41.1 42.7 42.1 44.4 43.1 12.8 12.4 39.8 27.1 24.1 27.6 15.8 18.8 13.9 17.9 10.9 14.1 20.0 10.8 11.0 2.1 22.5 28.5 17.1 15.6 31.3 4.4 26.4 22.7 35.6 19.2 15.4 18.1 37.2 22.3 23.0 24.5 25.3 25.3 18.1 33.5 26.4 23.3 25.2 17.0 12.7 8.2 18.8 23.4 6.2 19.6 24.2 16.0 22.5 44.7 17.5 33.0 12.5 16.8 32.9 13.7 31.2 22.2 28.9 14.5 16.7 20.4 7.9 0.0 21.6 22.1 8.9 22.9 19.9 22.0 51.3 24.7 54.5 13.7 31.4 CDKAL1 FLJ20342 ENSG00000145996 "CDK5 regulatory subunit associated protein 1 like 1" Q5VV42 6 20534457-21232404 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "tRNA processing" Transferase "Diabetes mellitus" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 5 "Astrocytes: 133.2;Excitatory neurons: 159.5;Inhibitory neurons: 134.1;Microglial cells: 198.6;Oligodendrocyte precursor cells: 198.5;Oligodendrocytes: 255.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in all" 5 "SCLC-21H: 188.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 23: Testis - Cell cycle regulation" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "unprognostic (9.64e-2)" "unprognostic (7.23e-3)" "unprognostic (8.40e-2)" "prognostic unfavorable (1.03e-4)" "unprognostic (1.05e-1)" "unprognostic (1.51e-2)" "unprognostic (3.47e-2)" "unprognostic (4.25e-3)" "unprognostic (6.72e-3)" "unprognostic (1.61e-3)" "unprognostic (1.42e-1)" "unprognostic (3.73e-2)" "unprognostic (5.79e-3)" "unprognostic (3.11e-2)" "unprognostic (1.75e-2)" "unprognostic (1.83e-2)" "unprognostic (2.60e-2)" 5.6 4.0 3.6 5.8 5.7 9.5 6.9 7.2 4.3 6.6 5.8 5.2 4.6 8.1 5.8 4.9 6.8 6.3 4.7 3.5 4.9 5.6 5.4 5.5 8.2 6.5 4.9 8.5 5.7 6.5 4.0 6.6 6.5 5.5 6.5 5.3 5.9 4.9 14.0 7.4 5.1 6.4 4.8 7.2 5.8 6.7 4.9 9.6 9.4 9.5 8.6 5.7 5.1 9.0 8.7 5.3 12.1 15.6 6.7 9.0 12.8 9.0 8.2 13.0 17.1 9.8 7.7 20.7 22.0 7.7 14.1 8.6 16.5 9.1 17.3 37.3 9.1 17.7 9.1 13.3 8.7 17.6 11.7 8.2 9.4 12.5 11.5 8.0 12.0 12.6 23.3 8.2 9.7 7.3 22.4 21.0 8.5 8.9 5.8 13.1 16.1 19.5 16.6 9.9 188.5 11.1 10.0 16.0 13.2 10.2 11.7 8.8 11.7 15.2 10.4 6.1 16.8 12.9 36.8 17.7 5.5 9.9 26.0 1.5 3.3 3.1 6.4 5.3 5.3 7.0 6.3 6.5 4.4 6.4 7.7 7.1 1.5 10.3 11.2 4.6 7.4 3.5 3.6 5.7 7.2 4.3 3.5 4.9 6.5 4.9 6.5 4.8 4.9 9.0 13.9 6.4 4.6 133.2 19.5 10.5 10.9 5.2 9.1 8.7 8.7 6.0 9.0 4.3 8.1 7.3 6.2 9.4 12.2 4.6 11.7 8.3 15.4 16.9 13.6 12.2 33.4 6.7 159.5 7.8 10.0 9.4 13.3 18.5 13.3 12.5 8.2 6.4 7.1 11.8 134.1 8.5 14.2 6.1 7.6 6.3 8.7 9.5 3.6 198.6 13.2 6.0 10.3 198.5 255.4 8.8 5.8 4.5 20.8 4.1 5.4 10.7 4.7 10.8 6.6 14.2 9.7 13.3 11.8 9.5 10.5 9.0 17.4 5.0 7.1 6.3 CDKL1 KKIALRE ENSG00000100490 "Cyclin dependent kinase like 1" Q00532 14 50326265-50416461 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 23.4;Excitatory neurons: 46.2;Oligodendrocyte precursor cells: 46.8;Oligodendrocytes: 25.4" "Low cancer specificity" "Detected in single" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "SK-BR-3: 18.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA059605, HPA065919" Uncertain Enhanced Nucleoplasm,Vesicles NA NA "Cluster 46: Basophils - DNA binding" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm Vesicles "HPA059605: AB_2684080, HPA065919: AB_2685578" "unprognostic (4.12e-3)" "unprognostic (3.22e-1)" "unprognostic (4.54e-2)" "unprognostic (8.04e-2)" "unprognostic (1.64e-2)" "unprognostic (1.02e-1)" "unprognostic (3.23e-3)" "unprognostic (9.36e-3)" "unprognostic (2.63e-1)" "unprognostic (9.99e-2)" "unprognostic (1.20e-1)" "unprognostic (9.36e-2)" "unprognostic (5.53e-8)" "unprognostic (1.21e-1)" "unprognostic (7.96e-2)" "unprognostic (9.39e-3)" "unprognostic (3.31e-3)" 13.5 3.6 3.4 4.9 4.4 3.6 3.5 1.4 9.0 13.9 3.7 8.8 13.2 13.9 3.2 5.2 15.4 5.2 2.3 5.5 2.3 19.4 1.6 6.5 6.5 2.0 2.1 13.8 1.3 1.2 0.6 6.5 2.9 5.9 6.6 20.2 2.8 9.0 7.1 13.5 6.9 8.5 2.9 7.0 4.9 2.0 1.8 1.9 7.9 1.0 2.6 6.9 6.6 8.1 7.7 4.9 3.5 4.3 5.3 6.1 2.3 2.2 3.2 1.9 2.0 4.0 5.9 6.1 2.8 3.2 3.2 5.9 0.8 0.3 1.9 8.9 3.1 12.2 4.6 3.9 6.2 9.7 5.3 1.5 3.0 3.2 8.0 2.4 6.7 10.3 3.3 4.8 1.1 2.5 2.8 4.7 1.9 2.6 3.9 3.3 3.8 3.1 5.3 6.6 4.6 3.4 4.2 18.3 2.1 1.3 2.4 6.2 4.0 6.7 4.1 7.1 5.0 2.4 1.8 2.9 1.7 8.7 7.6 3.2 1.4 2.6 3.5 1.4 3.1 2.6 2.3 3.2 0.8 3.0 1.9 1.9 0.7 2.3 0.2 0.8 2.4 1.3 3.4 4.4 1.4 9.0 5.5 2.3 2.0 2.1 2.9 2.9 1.8 8.1 3.2 19.2 9.9 6.5 3.0 3.1 4.1 0.2 3.4 0.7 0.4 0.5 0.5 0.0 2.6 11.0 0.0 0.1 2.3 7.2 5.9 1.4 0.4 23.4 9.6 3.3 1.8 6.1 46.2 1.8 0.1 7.6 1.1 4.9 1.3 3.2 6.4 0.3 0.4 0.0 20.6 2.1 2.0 0.9 1.5 1.5 9.0 1.5 0.0 7.5 0.8 0.9 2.1 46.8 25.4 1.9 4.8 3.4 0.2 3.1 4.9 8.0 20.4 0.7 0.0 4.0 4.6 0.0 0.3 4.7 2.7 0.3 4.2 3.6 5.2 2.2 CDKL2 "KKIAMRE, P56" ENSG00000138769 "Cyclin dependent kinase like 2" Q92772 4 75576496-75630716 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 8.3;choroid plexus: 8.6;retina: 9.6;testis: 11.6" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 76.4;Early spermatids: 57.8;Excitatory neurons: 32.8;Inhibitory neurons: 40.9;Oligodendrocytes: 46.4;Spermatocytes: 101.7" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A-431: 2.1;HHSteC: 1.9;RPTEC TERT1: 4.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040672 Approved Nucleoplasm,Centrosome NA NA "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 66: Spermatocytes - Spermatogenesis" "Nucleoplasm, Centrosome" "HPA040672: AB_10794744" "unprognostic (2.07e-1)" "unprognostic (9.96e-2)" "unprognostic (6.91e-2)" "unprognostic (3.80e-5)" "unprognostic (3.43e-2)" "unprognostic (2.71e-2)" "unprognostic (1.59e-1)" "unprognostic (8.14e-3)" "unprognostic (1.58e-1)" "unprognostic (1.62e-1)" "unprognostic (5.85e-2)" "unprognostic (1.27e-1)" "prognostic favorable (6.88e-15)" "unprognostic (5.91e-2)" "unprognostic (1.70e-1)" "unprognostic (1.64e-1)" "unprognostic (7.52e-2)" 0.1 1.0 6.3 0.3 6.7 0.0 0.3 4.1 8.3 0.6 8.6 0.7 0.1 0.6 0.9 0.8 1.6 0.4 0.3 6.5 6.1 5.9 0.0 4.7 0.3 6.0 4.8 1.6 0.5 2.5 1.5 0.0 6.5 0.6 0.9 9.6 0.3 0.6 0.0 0.2 0.1 0.4 4.9 0.1 0.6 11.6 5.8 0.0 3.1 0.0 0.6 0.2 0.3 8.3 2.1 0.3 0.1 0.0 0.1 0.1 0.0 0.1 0.8 1.0 0.9 0.1 0.5 0.0 0.3 0.0 1.0 0.2 0.0 0.2 0.9 0.1 1.5 0.0 0.1 0.0 1.9 0.0 0.0 0.6 1.0 0.1 0.3 0.9 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 4.2 0.1 1.1 0.9 0.0 0.0 0.5 1.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.7 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 6.3 6.7 4.1 8.3 6.5 6.1 6.0 4.8 6.5 4.9 5.8 8.3 0.2 25.6 76.4 5.9 0.4 0.1 0.5 0.6 0.6 17.7 0.7 3.0 0.9 1.5 4.7 9.2 4.2 0.1 0.3 3.0 7.9 1.9 57.8 11.6 1.4 0.2 1.8 0.0 32.8 0.2 0.6 1.2 1.1 2.5 1.3 1.0 0.4 0.0 0.1 10.1 40.9 2.3 0.0 0.0 0.4 20.7 1.8 0.5 1.8 3.7 0.0 11.6 0.0 5.5 46.4 0.1 1.0 1.2 0.3 0.2 0.0 29.5 18.6 20.2 0.0 0.4 1.1 101.7 4.1 0.8 0.3 0.3 2.7 0.2 2.7 0.2 CDKL3 NKIAMRE ENSG00000006837 "Cyclin dependent kinase like 3" Q8IVW4 5 134286350-134371047 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 16.2" "Group enriched" "Detected in many" 6 "Early spermatids: 342.0;Late spermatids: 295.3" "Low cancer specificity" "Detected in single" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027751 Uncertain Nucleoplasm,Vesicles NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 78: Testis - Spermatogenesis" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 23: Spermatids - Flagellum & Golgi organization" "Nucleoplasm, Vesicles" "HPA027751: AB_10601256" "unprognostic (4.70e-2)" "unprognostic (2.15e-2)" "unprognostic (2.35e-1)" "unprognostic (1.48e-1)" "unprognostic (1.43e-1)" "unprognostic (3.98e-2)" "unprognostic (3.43e-3)" "unprognostic (5.93e-2)" "unprognostic (2.12e-3)" "unprognostic (1.49e-1)" "unprognostic (8.47e-4)" "unprognostic (2.82e-1)" "unprognostic (9.85e-4)" "unprognostic (8.33e-2)" "unprognostic (4.88e-2)" "unprognostic (7.10e-3)" "unprognostic (3.43e-3)" 0.7 0.8 2.5 0.5 2.8 0.2 0.6 2.5 4.4 0.8 1.3 0.8 0.5 1.1 0.6 0.6 1.2 0.6 2.7 2.4 2.7 1.5 0.8 0.5 0.7 2.9 2.6 0.7 0.5 1.0 0.6 0.4 3.0 0.7 0.6 4.2 0.4 0.8 3.4 0.6 0.6 1.5 3.1 0.7 0.5 16.2 2.8 0.9 1.2 3.3 0.9 0.6 0.5 5.0 0.5 1.3 1.7 1.2 2.7 2.4 0.7 1.7 1.4 0.7 1.7 1.2 0.8 1.3 1.0 1.1 3.3 0.5 1.5 1.0 1.2 1.6 1.0 0.8 1.7 1.9 1.7 0.3 0.5 1.1 2.5 2.2 0.6 1.2 0.7 3.4 1.1 0.7 1.9 0.6 1.2 4.6 1.2 0.3 0.5 1.9 0.6 0.4 0.9 0.5 2.5 0.8 1.8 0.1 2.1 1.8 1.0 0.9 0.5 1.4 0.3 1.9 0.5 1.8 2.5 2.9 2.1 1.4 1.1 0.0 0.3 0.3 0.3 0.4 1.4 0.5 0.4 0.9 1.0 0.3 1.3 1.3 0.0 0.6 0.1 0.5 0.9 0.4 2.5 2.8 2.5 4.4 2.4 2.7 2.9 2.6 3.0 3.1 2.8 5.0 4.1 0.0 3.7 50.6 2.0 10.8 6.4 18.8 4.0 13.3 4.5 5.8 2.2 2.8 9.9 5.5 4.2 3.1 3.2 0.5 9.8 3.5 342.0 7.5 6.4 4.6 3.0 4.8 41.6 5.1 1.8 6.2 1.5 3.7 3.8 7.0 3.6 2.3 3.6 6.7 52.0 1.5 18.3 2.1 19.4 295.3 5.0 2.8 10.6 16.9 2.4 10.8 3.1 32.6 50.7 1.5 1.6 9.1 1.4 4.3 1.3 9.5 12.9 9.7 0.0 6.3 7.9 35.3 17.2 1.7 11.1 4.5 3.4 6.2 0.9 3.8 CDKL4 ENSG00000205111 "Cyclin dependent kinase like 4" Q5MAI5 2 39175646-39229588 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "choroid plexus: 2.0;testis: 2.9" "Cell type enhanced" "Detected in some" "Early spermatids: 11.8;Excitatory neurons: 5.4;Late spermatids: 6.8;Respiratory ciliated cells: 5.9;Spermatocytes: 8.7;Spermatogonia: 4.3" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HL-60: 2.1;RT4: 1.3;SH-SY5Y: 2.6" "Low region specificity" "Detected in all" HPA067895 Uncertain NA NA "Cluster 35: T-regs - Unknown function" "Cluster 49: Ciliated cells - Cilium organization" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA067895: AB_2685920" "unprognostic (3.57e-2)" "unprognostic (3.92e-2)" "unprognostic (1.14e-1)" "unprognostic (1.98e-2)" "unprognostic (3.29e-1)" "unprognostic (7.46e-3)" "unprognostic (3.26e-2)" "unprognostic (4.26e-1)" "unprognostic (3.82e-2)" "unprognostic (6.13e-3)" "unprognostic (1.77e-2)" "unprognostic (8.43e-2)" "unprognostic (8.45e-4)" "unprognostic (8.59e-2)" "unprognostic (4.95e-1)" "unprognostic (3.08e-1)" "unprognostic (3.26e-2)" 0.1 0.4 0.6 0.0 0.6 0.0 0.1 0.7 0.7 0.1 2.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.1 0.7 1.1 0.1 0.0 0.2 0.1 0.5 0.6 0.1 0.1 0.2 0.5 0.4 0.5 0.1 0.0 0.3 0.0 0.0 0.1 0.1 0.1 0.0 0.2 0.1 0.1 2.9 1.0 0.0 0.1 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.1 2.1 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.1 1.3 0.2 2.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.6 0.6 0.7 0.7 0.7 1.1 0.5 0.6 0.5 0.2 1.0 0.4 0.5 3.2 0.0 0.7 0.0 0.1 0.2 0.3 0.0 0.1 0.6 0.5 0.2 0.0 2.0 0.0 0.0 0.2 0.2 0.2 0.0 0.2 11.8 1.2 0.3 0.3 0.0 0.0 5.4 0.2 0.4 0.2 1.1 1.8 0.0 0.2 0.0 0.1 0.2 0.0 3.4 0.0 2.0 0.0 0.0 6.8 0.3 0.2 0.0 1.9 0.0 0.2 0.0 1.5 0.4 0.4 0.1 0.4 0.1 0.4 0.0 0.3 5.9 0.8 0.0 0.5 0.1 8.7 4.3 0.0 0.0 0.0 0.3 0.2 0.0 0.1 CDKL5 "CFAP247, EIEE2, STK9" ENSG00000008086 "Cyclin dependent kinase like 5" O76039 X 18425583-18653629 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 216.6;Horizontal cells: 80.8;Inhibitory neurons: 116.1;Oligodendrocytes: 79.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in some" "basophil: 5.7" "Lineage enriched" "Detected in single" 11 "granulocytes: 5.7" "Cell line enhanced" "Detected in many" "A549: 10.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002847, CAB011577" Approved Supported Nucleoplasm NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 58: Brain - Synaptic function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "CAB011577: AB_727019, HPA002847: AB_1080107" "unprognostic (7.01e-2)" "unprognostic (4.86e-2)" "unprognostic (1.41e-1)" "unprognostic (1.25e-4)" "unprognostic (1.17e-1)" "unprognostic (1.61e-2)" "unprognostic (1.72e-2)" "unprognostic (1.67e-1)" "unprognostic (2.07e-1)" "unprognostic (9.63e-3)" "unprognostic (2.05e-3)" "unprognostic (1.66e-1)" "prognostic favorable (5.54e-4)" "unprognostic (7.67e-3)" "unprognostic (1.29e-1)" "unprognostic (2.67e-3)" "unprognostic (1.99e-1)" 2.0 1.6 4.9 1.1 6.7 2.5 2.5 0.0 11.7 3.9 0.0 1.9 0.9 2.6 1.9 3.5 1.7 1.8 3.8 6.8 0.0 3.5 1.2 4.6 0.8 0.0 2.5 3.8 2.4 2.4 1.7 3.2 0.0 3.6 1.2 12.2 2.2 2.3 1.7 2.2 0.9 2.5 0.0 1.2 2.4 7.1 5.7 1.7 3.0 2.0 1.1 2.7 3.4 5.4 1.1 10.0 2.6 2.2 2.4 3.6 1.7 1.7 3.0 2.0 2.5 3.3 1.5 1.5 0.3 1.0 4.5 0.5 3.2 1.8 4.3 0.4 1.7 0.1 5.5 2.1 1.1 0.2 0.7 1.7 1.9 5.4 4.9 1.3 1.0 1.6 0.2 1.5 2.7 1.0 0.6 0.8 5.2 0.9 2.3 0.6 3.0 0.1 1.8 7.1 0.5 3.2 2.7 0.9 1.5 4.4 1.3 0.4 6.2 2.5 1.7 5.5 1.3 0.3 0.1 0.3 1.4 0.4 3.0 5.7 0.5 1.1 0.3 0.3 0.1 0.1 0.2 0.1 0.1 0.3 0.3 0.2 2.0 0.2 0.3 0.5 0.1 0.1 4.9 6.7 0.0 11.7 6.8 0.0 0.0 2.5 0.0 0.0 5.7 5.4 9.4 25.6 24.8 37.5 2.8 0.9 10.7 0.7 4.6 19.0 7.9 6.3 12.9 5.7 5.3 7.3 33.3 27.4 3.8 1.3 7.9 7.7 34.3 6.5 8.4 6.3 2.4 2.7 216.6 9.6 3.1 7.4 7.7 7.9 1.3 3.9 6.1 3.4 4.2 80.8 116.1 1.6 2.0 4.4 0.5 55.3 5.9 4.9 0.0 34.7 4.6 23.5 0.0 41.7 79.7 8.2 0.8 5.3 4.3 16.2 0.6 8.9 4.0 20.4 32.9 7.2 8.4 5.8 10.1 4.2 1.3 47.3 2.3 5.7 1.8 22.9 CDS1 ENSG00000163624 "CDP-diacylglycerol synthase 1" Q92903 4 84583127-84651334 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 129.8;Respiratory ciliated cells: 210.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "CAPAN-2: 46.1;hTCEpi: 56.9;OE19: 45.5;SK-BR-3: 62.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036187, HPA064546" Enhanced NA NA "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 49: Ciliated cells - Cilium organization" "HPA036187: AB_10601797, HPA064546: AB_2732714" "unprognostic (8.74e-2)" "unprognostic (7.11e-2)" "prognostic favorable (5.22e-4)" "unprognostic (2.73e-3)" "unprognostic (1.45e-2)" "unprognostic (1.73e-1)" "unprognostic (3.10e-3)" "unprognostic (3.11e-1)" "unprognostic (2.62e-1)" "unprognostic (1.35e-1)" "unprognostic (1.16e-1)" "unprognostic (6.67e-2)" "prognostic favorable (0.00e+0)" "unprognostic (2.23e-1)" "unprognostic (1.78e-1)" "unprognostic (3.06e-1)" "unprognostic (2.06e-1)" 1.0 6.1 8.8 1.5 9.5 0.6 10.2 11.1 17.8 6.3 19.0 20.0 40.2 3.0 29.0 20.1 32.2 8.0 0.5 8.9 11.6 14.9 0.5 10.7 0.6 15.9 11.2 5.2 4.7 28.3 4.8 7.2 16.6 9.4 21.3 22.4 12.5 4.7 0.1 15.4 34.4 1.2 9.9 1.6 18.4 7.4 14.7 3.5 30.4 0.1 5.1 6.7 9.2 8.2 26.5 0.6 1.5 0.3 0.1 0.0 26.5 0.0 0.4 0.6 0.5 11.2 46.1 0.0 2.0 0.0 5.4 27.2 8.5 23.2 0.3 1.8 12.6 0.0 3.8 2.7 0.0 0.8 1.8 0.2 56.9 0.0 8.2 1.0 0.0 1.5 0.1 0.0 0.1 18.8 0.2 0.1 3.8 45.5 1.8 0.1 0.0 5.7 12.7 20.0 10.6 0.2 2.9 62.1 0.1 4.9 19.0 0.5 0.0 0.0 1.4 2.8 3.5 0.0 0.0 0.0 2.6 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.8 9.5 11.1 17.8 8.9 11.6 15.9 11.2 16.6 9.9 14.7 8.2 0.8 16.0 42.3 33.3 0.4 29.1 27.7 26.4 26.7 16.7 26.6 13.6 1.4 24.3 39.5 40.5 10.4 60.0 0.4 63.0 3.9 26.4 12.1 129.8 3.8 3.3 22.3 0.0 43.1 22.8 12.1 3.5 41.3 45.2 0.0 15.4 1.4 0.7 12.7 21.9 64.6 53.9 48.8 3.5 13.9 4.5 0.6 3.5 0.0 9.4 1.2 29.0 0.0 3.5 2.4 40.8 30.4 0.4 0.1 30.8 80.0 15.9 210.7 32.0 0.0 1.2 4.3 13.1 6.6 41.1 54.1 57.3 1.6 4.8 51.6 38.3 CDS2 ENSG00000101290 "CDP-diacylglycerol synthase 2" O95674 20 5126879-5197887 "Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-266/84: 160.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019698 Approved Approved "Endoplasmic reticulum" No No "Cluster 38: Basophils - Unknown function" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 16: U-266 - Nucleosome" "Cluster 48: Smooth muscle cells - ECM organization" "Endoplasmic reticulum" "HPA019698: AB_1846464" "unprognostic (4.59e-2)" "unprognostic (1.98e-1)" "unprognostic (2.39e-1)" "unprognostic (3.37e-2)" "unprognostic (1.15e-1)" "unprognostic (1.99e-1)" "unprognostic (1.44e-1)" "unprognostic (3.22e-1)" "unprognostic (1.71e-2)" "unprognostic (1.48e-1)" "unprognostic (3.35e-3)" "unprognostic (1.65e-1)" "prognostic favorable (3.53e-9)" "unprognostic (8.89e-2)" "unprognostic (3.53e-1)" "unprognostic (1.38e-1)" "unprognostic (2.44e-1)" 14.3 13.8 30.0 9.1 32.4 13.0 10.6 22.9 28.6 10.5 2.1 13.0 5.2 11.5 8.2 9.2 10.7 8.9 24.8 30.3 34.6 14.6 12.8 13.4 8.8 27.2 36.1 9.3 6.5 17.3 14.4 9.9 37.4 13.4 10.7 31.5 7.6 16.7 9.7 5.9 10.1 18.0 18.8 9.4 10.6 11.7 42.5 13.3 12.5 12.7 12.6 10.8 7.7 21.7 25.4 27.4 28.1 13.7 16.4 14.9 11.7 13.9 28.5 22.7 32.2 17.8 23.8 19.8 6.8 26.4 41.1 36.5 23.1 29.5 23.9 18.4 6.8 23.5 7.9 27.0 15.3 13.9 8.1 12.8 16.1 29.8 11.5 20.3 30.7 26.5 11.6 23.9 21.4 4.6 30.1 5.7 12.1 12.4 7.6 25.0 22.5 9.4 14.5 25.0 11.4 15.5 15.3 26.2 34.6 33.8 16.4 6.7 25.4 15.6 11.6 14.1 14.0 20.8 160.2 15.9 7.4 11.7 8.1 55.3 17.3 21.2 15.2 14.7 16.6 12.1 15.6 17.3 13.8 11.4 12.0 11.8 49.7 12.0 13.4 10.9 19.5 23.7 30.0 32.4 22.9 28.6 30.3 34.6 27.2 36.1 37.4 18.8 42.5 21.7 43.3 19.2 15.7 36.9 36.2 17.6 30.3 33.0 14.2 60.1 17.7 14.4 55.2 18.6 19.6 33.1 95.9 22.2 29.6 15.3 5.9 33.1 71.6 20.1 14.0 42.3 10.7 14.9 39.3 22.7 40.0 17.9 15.3 21.5 21.0 20.5 27.8 21.7 60.8 43.7 52.0 12.4 12.2 36.6 26.1 33.3 16.1 31.5 32.0 21.5 38.7 21.9 28.8 28.6 56.1 31.7 20.3 24.8 48.9 23.1 15.7 13.2 23.5 65.5 19.7 19.7 52.1 26.8 34.7 14.8 15.3 16.3 36.7 13.0 13.1 29.1 CDY1 CDY1A ENSG00000172288 "Chromodomain Y-linked 1" Q9Y6F8 Y 25622162-25624902 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA066682 Supported NA NA "HPA066682: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CDY1B ENSG00000172352 "Chromodomain Y-linked 1B" Q9Y6F8 Y 24045229-24048019 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 23 "testis: 2.2" "Cell type enhanced" "Detected in single" "Early spermatids: 1.6" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA066682 Supported NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 23: Spermatids - Flagellum & Golgi organization" "HPA066682: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CDY2A CDY2 ENSG00000182415 "Chromodomain Y-linked 2A" Q9Y6F7 Y 18025787-18027746 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 16 "epididymis: 1.1;testis: 2.0" "Cell type enriched" "Detected in single" 18 "Collecting duct cells: 1.8" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA066682 Supported NA NA "Cluster 68: Epididymis - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA066682: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CDY2B CDY ENSG00000129873 "Chromodomain Y-linked 2B" Q9Y6F7 Y 17878260-17880220 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA066682 Supported NA NA "HPA066682: " 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CEPT1 ENSG00000134255 "Choline/ethanolamine phosphotransferase 1" Q9Y6K0 1 111139627-111185104 "Enzymes, Metabolic proteins, Predicted membrane proteins, Transporters" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 64: Macrophages - Immune response" "Cluster 30: Epithelial cell lines - Translation" "Cluster 57: B-cells - Immune response" "unprognostic (1.16e-1)" "unprognostic (2.42e-1)" "unprognostic (1.47e-3)" "unprognostic (1.83e-2)" "prognostic favorable (4.96e-4)" "unprognostic (5.52e-2)" "unprognostic (1.10e-1)" "unprognostic (5.61e-2)" "unprognostic (1.54e-3)" "unprognostic (1.84e-1)" "unprognostic (9.20e-3)" "unprognostic (1.03e-1)" "unprognostic (4.60e-2)" "unprognostic (3.58e-2)" "unprognostic (1.10e-1)" "unprognostic (5.88e-2)" "unprognostic (1.27e-2)" 20.7 17.9 14.9 20.2 15.1 5.4 12.0 15.7 19.5 11.0 15.4 12.0 17.0 12.5 15.9 13.2 14.0 13.3 6.7 14.3 16.5 19.9 36.2 13.3 31.7 15.8 14.8 19.2 10.6 18.7 6.1 17.0 15.8 10.8 15.4 8.1 17.5 9.5 9.2 15.1 18.3 12.7 16.5 27.6 14.6 8.9 15.2 20.2 16.8 10.8 22.9 16.8 9.9 18.4 27.3 10.0 11.6 11.3 44.8 22.0 28.1 29.5 16.5 13.4 16.0 8.7 30.0 32.1 31.7 15.2 17.0 32.6 16.7 22.9 18.9 24.1 26.4 14.0 16.3 19.6 29.9 33.4 19.3 18.1 42.8 9.8 46.1 25.4 18.0 32.8 30.9 20.5 17.6 19.8 34.6 32.9 18.0 43.2 20.3 18.4 36.8 26.3 22.0 17.0 15.2 8.2 27.1 40.2 33.2 22.4 21.8 35.5 15.8 21.7 13.6 47.4 20.0 18.5 21.6 24.9 29.2 29.6 42.0 4.4 10.0 5.8 7.9 18.3 10.3 17.9 8.7 8.2 12.1 17.8 10.0 11.0 2.5 8.7 27.5 9.3 8.3 7.4 14.9 15.1 15.7 19.5 14.3 16.5 15.8 14.8 15.8 16.5 15.2 18.4 11.5 35.3 14.9 20.9 45.5 13.0 16.5 30.8 13.6 25.1 11.1 6.2 3.6 17.2 26.9 36.8 35.5 30.1 16.7 20.7 5.9 13.4 1.9 15.8 16.9 12.3 10.2 21.4 42.4 8.1 19.7 15.2 12.2 11.1 19.0 15.2 19.6 37.8 28.3 28.6 49.2 15.0 20.3 52.1 13.9 3.7 14.6 26.0 16.0 42.2 24.7 10.0 34.0 47.3 59.5 8.5 19.9 17.0 18.5 16.0 26.1 15.2 29.2 29.3 13.1 9.9 10.1 17.1 14.7 13.0 15.3 19.0 17.2 19.1 14.4 15.4 CERK "dA59H18.2, dA59H18.3, DKFZp434E0211, FLJ21430, FLJ23239, hCERK, KIAA1646, LK4" ENSG00000100422 "Ceramide kinase" Q8TCT0 22 46684410-46738252 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA064699 Approved Vesicles NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 12: NES - Nervous system development" "Cluster 24: Non-specific - Transcription regulation" Vesicles "HPA064699: AB_2685327" "unprognostic (2.93e-2)" "unprognostic (1.93e-1)" "unprognostic (6.52e-2)" "prognostic unfavorable (4.75e-4)" "unprognostic (2.67e-2)" "unprognostic (1.49e-3)" "unprognostic (8.55e-2)" "unprognostic (3.60e-2)" "unprognostic (3.87e-1)" "unprognostic (1.35e-2)" "prognostic favorable (2.35e-4)" "unprognostic (2.26e-1)" "unprognostic (1.50e-3)" "unprognostic (1.27e-1)" "unprognostic (4.78e-1)" "unprognostic (3.38e-1)" "prognostic unfavorable (1.58e-4)" 15.7 23.7 17.5 22.2 18.1 21.1 12.7 33.2 22.5 17.8 16.4 17.9 31.6 17.5 6.0 14.8 18.2 17.4 39.0 18.3 37.4 19.5 18.9 16.6 26.1 32.1 34.5 26.6 30.2 11.5 49.0 10.0 33.2 11.7 14.9 21.1 17.5 13.4 20.8 16.3 31.2 15.2 20.8 19.4 21.9 6.0 26.2 38.7 21.0 19.2 25.2 13.7 12.4 18.4 25.6 15.1 71.6 22.6 40.3 30.2 6.7 43.7 33.8 24.5 17.2 22.3 8.4 35.3 19.9 46.9 15.1 16.3 30.4 19.8 24.9 12.6 33.0 15.8 36.9 29.0 27.9 49.9 4.0 25.3 25.0 26.7 9.1 39.2 73.5 37.1 12.1 44.5 45.4 1.9 34.0 24.8 32.4 10.3 16.3 62.8 81.2 40.4 14.7 0.5 66.4 60.6 21.5 10.3 47.1 16.5 11.3 37.6 67.4 50.2 26.8 37.5 64.4 45.7 59.5 22.3 53.5 28.0 41.7 0.7 3.0 3.7 10.3 7.0 17.9 2.0 10.7 10.0 5.4 2.1 6.3 5.8 4.2 2.6 8.7 5.7 10.4 4.4 17.5 18.1 33.2 22.5 18.3 37.4 32.1 34.5 33.2 20.8 26.2 18.4 28.6 9.6 16.6 16.0 17.0 3.4 6.3 6.1 18.2 24.4 6.1 9.8 44.2 10.0 11.0 1.8 6.2 2.4 25.4 23.4 15.6 12.8 7.8 10.3 19.8 27.4 14.4 8.0 11.7 11.8 1.4 14.1 9.2 19.8 10.1 10.2 25.4 22.1 10.8 26.9 21.9 6.6 8.2 24.8 16.9 16.0 9.6 22.1 3.6 15.9 18.6 25.6 22.6 9.5 4.2 10.9 15.2 15.1 43.3 2.1 50.0 16.8 0.7 9.7 0.0 8.3 13.2 4.7 1.7 11.0 4.4 1.8 37.6 5.3 20.0 1.7 CERS2 "FLJ10243, LASS2, SP260" ENSG00000143418 "Ceramide synthase 2" Q96G23 1 150960583-150975003 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 732.2" "Cell type enhanced" "Detected in all" "Hepatocytes: 200.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027262, HPA078737" Approved Supported "Nuclear membrane,Endoplasmic reticulum" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 15: Liver - Metabolism" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 2: Hepatocytes - Metabolism" "Nuclear membrane, Endoplasmic reticulum" "HPA027262: AB_1852717, HPA078737: " "unprognostic (1.01e-1)" "unprognostic (2.70e-3)" "unprognostic (3.72e-2)" "unprognostic (1.29e-2)" "unprognostic (8.23e-2)" "unprognostic (2.03e-2)" "unprognostic (7.05e-2)" "unprognostic (1.60e-1)" "unprognostic (2.34e-1)" "unprognostic (4.05e-2)" "unprognostic (8.17e-3)" "unprognostic (1.11e-1)" "unprognostic (2.63e-2)" "unprognostic (1.56e-1)" "unprognostic (7.21e-2)" "unprognostic (1.09e-1)" "unprognostic (1.85e-1)" 95.0 307.2 126.3 53.1 171.3 80.1 100.1 170.2 165.7 96.8 141.7 81.5 94.5 79.9 89.6 46.2 94.1 97.1 71.8 125.5 144.8 261.4 732.2 135.0 56.4 201.5 168.5 104.4 129.3 159.4 84.7 113.8 192.1 83.2 88.6 38.1 61.5 82.7 37.5 46.9 102.8 99.2 158.7 65.1 128.0 49.8 157.2 67.5 161.4 57.3 69.9 91.0 70.7 223.7 154.3 175.8 138.1 277.9 395.1 237.1 100.8 153.1 217.9 278.1 189.1 188.4 248.5 137.7 244.3 242.4 174.6 165.5 195.5 160.7 247.6 194.0 157.7 193.4 107.5 219.3 277.6 216.4 218.5 214.0 197.9 254.3 315.6 341.4 174.3 189.8 210.4 281.0 363.4 255.6 134.2 135.7 200.9 499.4 299.6 160.0 95.4 208.4 311.5 127.2 121.7 185.8 169.6 278.7 183.8 172.1 335.6 296.5 145.4 196.4 93.6 180.1 267.9 189.5 229.0 841.7 222.4 91.0 200.7 212.1 80.2 136.0 76.9 43.7 93.6 34.6 70.3 78.8 69.5 31.9 60.6 60.1 86.5 63.4 32.8 70.1 86.7 88.5 126.3 171.3 170.2 165.7 125.5 144.8 201.5 168.5 192.1 158.7 157.2 223.7 46.3 67.3 67.9 8.8 23.1 24.1 38.2 37.0 18.2 7.5 52.8 27.6 2.8 120.1 23.2 53.3 4.2 77.8 40.2 60.7 13.7 104.6 7.5 24.9 39.9 47.9 24.6 24.8 5.5 92.8 42.4 44.2 16.3 29.7 36.8 33.0 38.9 200.5 55.9 3.3 5.9 29.3 30.5 45.2 35.2 7.9 56.2 54.5 37.4 5.6 39.4 26.5 26.8 7.5 51.3 103.7 32.4 40.3 29.2 52.4 98.8 81.7 21.2 9.9 39.5 37.2 33.8 13.8 6.8 13.9 15.6 54.2 34.3 39.0 29.1 34.2 CERS3 "LASS3, MGC27091" ENSG00000154227 "Ceramide synthase 3" Q8IU89 15 100400395-100544995 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism" Transferase Ichthyosis "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "esophagus: 55.1;skin 1: 64.0;vagina: 30.3" "Group enriched" "Detected in some" 5 "Basal keratinocytes: 18.9;Basal squamous epithelial cells: 39.3;Early spermatids: 23.5;Late spermatids: 17.5;Spermatocytes: 28.2;Squamous epithelial cells: 48.3;Suprabasal keratinocytes: 50.2" "Cancer enhanced" "Detected in some" "head and neck cancer: 14.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 6 "hTCEpi: 65.4" "Not detected" "Not detected" "Not detected" "Not detected" "HPA006092, HPA024356" Approved Supported Nucleoplasm NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 61: Squamous epithelial cells - Keratinization" Nucleoplasm "HPA006092: AB_1079236, HPA024356: AB_1852721" "unprognostic (5.01e-3)" "unprognostic (3.43e-2)" "unprognostic (6.47e-4)" "unprognostic (2.35e-2)" "unprognostic (5.58e-2)" "unprognostic (1.68e-1)" "unprognostic (6.84e-3)" "unprognostic (3.23e-1)" "unprognostic (1.43e-1)" "unprognostic (2.09e-1)" "unprognostic (1.31e-5)" "unprognostic (2.65e-1)" "unprognostic (4.74e-4)" "unprognostic (1.83e-1)" "unprognostic (4.33e-2)" "unprognostic (1.78e-1)" "unprognostic (4.05e-3)" 0.1 0.0 0.1 0.0 0.2 0.2 3.3 0.3 0.2 15.1 0.0 0.0 0.0 0.0 0.5 55.1 0.7 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.0 0.4 0.0 0.1 0.6 0.0 0.1 8.4 0.1 0.6 64.0 0.1 0.0 0.0 0.1 0.1 18.3 0.2 0.4 0.1 0.0 16.0 0.3 30.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.4 0.0 10.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 65.4 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.2 0.3 0.2 0.1 0.0 0.1 0.1 0.1 0.0 0.2 0.1 0.1 0.0 0.0 1.3 0.0 18.9 5.0 3.9 39.3 0.4 0.1 0.3 0.5 0.0 4.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 23.5 0.2 0.0 0.2 0.0 0.0 1.6 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.2 0.0 0.0 0.0 2.1 17.5 0.6 0.1 0.0 0.0 0.0 0.2 0.0 2.0 1.4 0.1 0.0 0.0 0.0 1.0 0.0 0.0 0.2 0.0 0.0 0.0 0.2 28.2 0.7 48.3 50.2 0.0 0.1 0.0 0.0 6.0 CERS4 "FLJ12089, LASS4, Trh1" ENSG00000090661 "Ceramide synthase 4" Q9HA82 19 8206736-8262421 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Hepatocytes: 71.3;Muller glia cells: 150.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "Hep G2: 55.1;NB-4: 99.8;U-937: 61.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033734, HPA054729" Uncertain Supported Nucleoplasm,Vesicles NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 22: Non-specific - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 5: Muller glia cells - Visual perception" "Nucleoplasm, Vesicles" "CAB033734: AB_2132977, HPA054729: " "unprognostic (5.96e-2)" "prognostic favorable (2.71e-4)" "unprognostic (2.46e-2)" "unprognostic (2.82e-2)" "unprognostic (1.30e-1)" "prognostic favorable (7.83e-4)" "unprognostic (1.74e-1)" "prognostic favorable (3.45e-5)" "unprognostic (1.48e-2)" "unprognostic (3.32e-1)" "prognostic favorable (8.05e-4)" "unprognostic (1.77e-1)" "prognostic favorable (9.63e-5)" "unprognostic (6.08e-3)" "unprognostic (2.69e-2)" "unprognostic (2.91e-2)" "unprognostic (8.08e-3)" 13.6 13.0 31.8 10.0 38.9 3.4 31.1 26.6 37.1 35.9 18.7 17.7 6.3 21.5 61.5 64.3 21.3 11.2 14.8 35.3 25.2 27.8 57.7 19.4 19.9 36.9 30.5 22.0 89.1 29.0 22.2 1.9 30.8 32.9 3.9 36.9 55.0 17.6 3.1 47.7 15.2 12.0 26.8 17.7 26.8 11.5 30.7 13.1 51.9 5.3 20.4 18.4 32.7 44.0 0.4 2.1 2.1 25.0 0.8 0.2 1.7 3.1 8.4 3.7 1.7 19.5 1.7 40.0 27.4 0.0 9.6 13.6 16.4 0.4 1.7 35.5 12.4 7.6 0.1 55.1 31.6 0.0 21.3 12.3 20.7 8.8 18.9 10.5 0.3 17.7 5.9 1.2 0.0 0.8 2.6 99.8 25.4 0.2 8.7 49.1 0.8 3.0 6.3 0.0 9.3 12.2 4.3 0.7 14.5 16.7 18.8 8.8 0.2 2.9 7.8 18.6 0.1 24.5 21.1 32.0 0.1 61.9 2.8 12.3 7.1 27.4 7.5 3.9 5.7 19.8 4.3 4.6 4.1 17.7 3.9 3.8 22.4 22.4 2.4 3.9 5.5 5.8 31.8 38.9 26.6 37.1 35.3 25.2 36.9 30.5 30.8 26.8 30.7 44.0 3.2 6.4 10.7 27.1 31.2 18.0 13.2 12.0 15.4 24.5 47.0 28.8 4.1 22.8 22.2 1.8 18.8 3.4 17.2 0.2 7.9 20.0 1.7 7.9 11.2 8.6 23.9 4.0 38.3 30.5 0.9 15.7 3.1 7.6 12.7 14.4 8.2 71.3 16.4 11.8 24.4 1.3 8.2 7.1 7.2 7.3 14.3 6.7 26.6 16.9 19.6 150.3 27.8 47.7 48.1 9.4 2.5 16.1 12.4 40.6 0.4 44.6 27.8 29.5 6.6 6.9 13.8 1.0 1.6 20.6 25.9 2.9 15.7 2.7 2.5 11.9 CERS5 "FLJ25304, LASS5, MGC45411, Trh4" ENSG00000139624 "Ceramide synthase 5" Q8N5B7 12 50129289-50167533 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Sphingolipid metabolism" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006780, HPA026589" Approved Approved "Nuclear membrane,Endoplasmic reticulum" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 35: Non-specific - Unknown function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 38: Extravillous trophoblasts - Unknown function" "Nuclear membrane, Endoplasmic reticulum" "HPA006780: , HPA026589: AB_1852727" "unprognostic (1.59e-2)" "unprognostic (9.83e-2)" "unprognostic (5.17e-2)" "unprognostic (3.64e-2)" "unprognostic (3.02e-1)" "unprognostic (2.49e-3)" "prognostic unfavorable (4.63e-5)" "unprognostic (5.56e-2)" "unprognostic (1.65e-2)" "unprognostic (9.26e-2)" "unprognostic (1.88e-3)" "unprognostic (5.67e-2)" "prognostic unfavorable (9.33e-11)" "unprognostic (8.37e-2)" "unprognostic (1.03e-1)" "prognostic favorable (5.76e-5)" "unprognostic (3.26e-1)" 26.2 22.3 27.6 4.8 28.5 5.1 26.6 29.7 48.1 37.2 27.4 24.1 3.0 30.5 12.0 24.0 28.2 6.9 16.2 27.7 29.6 44.1 14.2 22.9 6.1 28.3 28.6 35.1 22.9 9.1 42.3 5.5 28.9 31.2 2.9 5.5 21.5 3.5 5.5 34.1 20.6 4.6 27.5 29.2 21.6 13.8 29.5 7.6 24.8 2.3 3.7 29.5 29.2 29.0 12.1 13.2 17.1 3.5 6.5 3.9 10.6 23.3 6.6 8.0 7.4 36.2 13.9 10.6 20.2 24.4 7.7 7.9 6.1 4.4 6.7 23.4 12.7 6.1 11.2 23.2 16.5 8.0 12.4 19.4 13.9 11.6 6.3 18.7 11.9 10.0 6.1 10.8 8.6 18.7 15.4 45.6 8.2 4.1 7.0 10.7 4.3 12.7 28.7 17.7 5.2 6.9 10.3 9.4 33.6 10.7 13.0 9.9 10.6 17.6 10.2 11.6 8.0 8.1 14.3 11.6 12.8 5.9 8.4 36.3 23.0 42.4 37.0 37.4 28.7 22.0 28.6 28.6 26.8 30.6 20.1 28.9 41.2 39.6 55.1 36.0 37.1 37.1 27.6 28.5 29.7 48.1 27.7 29.6 28.3 28.6 28.9 27.5 29.5 29.0 14.9 19.2 18.4 22.5 17.7 17.3 20.9 29.1 12.0 41.0 11.5 9.8 6.8 14.3 16.5 14.7 20.9 32.9 23.1 8.1 7.9 21.2 0.9 7.7 16.7 17.2 15.6 9.1 47.7 14.0 65.2 21.9 10.7 11.8 15.2 15.0 18.2 4.6 19.0 32.0 56.1 7.9 28.5 17.9 18.3 2.2 16.8 14.3 12.4 20.6 26.6 21.3 24.7 40.2 34.8 19.0 6.8 17.3 12.7 15.5 14.2 7.7 8.6 44.3 32.9 18.2 20.8 7.6 8.1 9.3 14.3 33.7 22.1 15.7 6.7 14.7 CGAS "C6orf150, MB21D1" ENSG00000164430 "Cyclic GMP-AMP synthase" Q8N884 6 73413515-73452297 "Enzymes, Predicted intracellular proteins" "Antiviral defense, DNA damage, DNA repair, Host-virus interaction, Immunity, Innate immunity" "DNA-binding, Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 14.0" "Cell type enhanced" "Detected in some" "Adipocytes: 10.2;dendritic cells: 12.0;Glandular and luminal cells: 12.5;Hofbauer cells: 12.4;Macrophages: 10.0;monocytes: 27.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "Karpas-707: 37.1;RH-30: 43.8;RPMI-8226: 45.2" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA031700, HPA031702" Enhanced Supported Nucleoplasm NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 44: HDLM-2 - Immune response" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "HPA031700: AB_10601693, HPA031702: AB_2673999" "unprognostic (2.49e-1)" "unprognostic (2.36e-1)" "unprognostic (4.61e-2)" "unprognostic (4.95e-2)" "unprognostic (2.49e-2)" "unprognostic (1.81e-1)" "unprognostic (4.84e-3)" "unprognostic (1.01e-2)" "unprognostic (9.80e-2)" "unprognostic (4.25e-2)" "unprognostic (2.20e-2)" "unprognostic (2.77e-1)" "prognostic unfavorable (2.27e-7)" "unprognostic (1.93e-3)" "unprognostic (1.17e-2)" "unprognostic (1.86e-1)" "unprognostic (2.78e-1)" 2.9 1.1 1.7 6.4 2.1 14.0 1.7 2.2 3.0 2.4 1.7 1.9 2.7 1.9 0.6 2.3 1.8 2.6 1.5 1.9 2.0 1.1 0.8 3.5 7.4 2.6 2.2 1.2 1.2 0.6 0.6 3.1 2.6 1.9 1.8 0.2 1.8 1.8 0.5 1.1 2.5 2.0 2.4 5.2 2.3 1.0 3.0 2.3 1.6 0.9 4.7 4.3 2.1 3.4 19.9 5.8 0.1 0.2 1.2 2.7 0.1 10.1 3.7 11.3 12.6 20.7 14.2 0.2 20.9 4.3 6.3 10.1 9.8 0.2 12.0 31.9 0.0 16.9 8.2 0.1 4.0 12.3 11.5 1.6 3.2 11.8 0.1 0.0 3.5 0.1 0.0 37.1 8.7 8.0 0.0 27.1 6.2 2.4 11.2 23.4 43.8 45.2 0.0 7.3 0.3 0.1 17.3 0.4 10.2 0.2 0.0 33.9 5.0 0.0 9.1 8.5 0.2 8.1 19.8 0.2 0.1 17.5 11.4 26.3 12.7 19.0 6.0 17.5 4.7 8.4 7.9 5.9 7.5 6.7 1.8 3.4 8.5 4.2 11.6 17.6 8.0 6.0 1.7 2.1 2.2 3.0 1.9 2.0 2.6 2.2 2.6 2.4 3.0 3.4 10.2 3.2 4.8 0.0 4.7 0.0 0.0 0.0 0.0 0.0 2.6 1.8 0.0 0.0 0.6 0.0 0.0 0.2 12.0 0.0 0.0 2.0 0.0 8.4 8.5 6.0 0.0 0.0 0.0 3.9 0.7 2.3 0.0 12.5 5.1 1.0 0.0 0.0 12.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.0 0.0 0.0 27.4 0.0 0.0 0.0 0.0 5.9 0.0 0.0 3.0 0.0 0.0 0.2 2.9 0.0 0.0 0.0 3.8 0.0 0.0 0.0 0.0 0.3 8.0 0.7 0.0 0.0 CHAT ENSG00000070748 "Choline O-acetyltransferase" P28329 10 49609095-49667942 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Neurotransmitter biosynthesis" "Acyltransferase, Transferase" "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 10 "brain: 13.0;placenta: 5.5" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 15 "NB-4: 20.9" "Region enhanced" "Detected in many" "basal ganglia: 20.6" "Group enriched" "Detected in some" 7 "basal ganglia: 6.5;pons: 7.0;spinal cord: 12.0" "CAB002313, HPA048547, CAB079053" Supported Supported NA NA "Cluster 65: Brain - Ion transport" "Cluster 24: NB-4 - Immune response" "Cluster 33: Fibroblasts - ECM organization" "CAB002313: AB_563661, CAB079053: , HPA048547: AB_2680437" "unprognostic (2.34e-2)" "unprognostic (6.10e-2)" "unprognostic (5.28e-2)" "unprognostic (6.96e-2)" "unprognostic (2.80e-2)" "unprognostic (3.98e-1)" "unprognostic (1.09e-1)" 0.0 0.0 0.6 0.2 2.8 0.0 0.0 0.3 13.0 0.0 0.3 0.3 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.1 3.1 0.0 0.0 0.0 0.0 7.9 5.1 0.0 0.3 0.0 0.0 5.5 9.4 0.0 0.0 0.9 0.0 0.2 0.0 0.0 0.5 0.0 1.3 0.0 0.0 0.3 0.6 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.5 0.0 0.0 0.8 20.9 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.5 0.2 0.0 0.0 0.1 0.0 0.2 0.1 0.0 0.1 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.6 2.8 0.3 13.0 0.1 3.1 7.9 5.1 9.4 1.3 0.6 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 CHEK1 CHK1 ENSG00000149554 "Checkpoint kinase 1" O14757 11 125625665-125676255 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, DNA damage, DNA repair" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 25.7;lymphoid tissue: 20.7;seminal vesicle: 29.8" "Cell type enhanced" "Detected in many" "Cholangiocytes: 32.9;Erythroid cells: 34.5;Extravillous trophoblasts: 35.6;Spermatocytes: 48.9;Spermatogonia: 49.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in some" "Immune cell enhanced" "Detected in some" "T-reg: 6.2" "Group enriched" "Detected in many" 5 "granulocytes: 1.7;T-cells: 6.2" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in single" "Low region specificity" "Detected in many" HPA044364 Supported Nucleoplasm,Vesicles NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm Vesicles "HPA044364: AB_2678913" "unprognostic (6.74e-2)" "unprognostic (3.63e-1)" "prognostic favorable (3.62e-4)" "unprognostic (5.54e-2)" "unprognostic (2.17e-1)" "unprognostic (1.03e-1)" "prognostic unfavorable (3.70e-6)" "unprognostic (3.95e-3)" "unprognostic (1.26e-3)" "unprognostic (2.54e-2)" "prognostic unfavorable (3.10e-6)" "unprognostic (1.75e-1)" "prognostic unfavorable (1.04e-8)" "unprognostic (2.89e-2)" "unprognostic (2.64e-1)" "unprognostic (8.16e-2)" "unprognostic (1.33e-1)" 1.6 1.3 0.7 8.2 1.0 25.7 2.6 0.6 1.3 1.7 0.5 7.9 6.8 1.7 6.7 4.1 1.1 1.7 0.9 0.7 0.9 2.2 2.1 1.3 14.9 0.7 0.8 1.8 2.0 13.2 1.7 4.8 0.8 1.6 8.7 0.7 1.5 29.8 0.6 3.6 7.3 3.4 0.6 2.2 2.6 8.9 1.2 20.7 1.0 1.3 13.9 3.3 2.1 0.8 48.5 37.0 81.1 47.4 13.5 28.9 35.7 61.1 28.7 41.6 40.1 88.0 100.3 120.7 63.5 24.9 53.7 52.6 54.2 33.2 50.1 81.4 24.8 224.2 27.2 44.7 4.3 121.1 39.6 15.7 6.0 47.6 36.0 19.9 44.7 84.1 117.3 102.7 51.4 23.8 181.3 65.0 86.1 77.1 33.2 104.7 74.4 67.2 37.9 63.2 50.5 53.6 45.2 35.4 15.2 57.3 93.9 40.6 28.4 51.0 47.3 29.6 60.8 21.9 45.4 187.5 20.5 86.6 67.6 1.7 0.2 0.0 0.4 0.1 0.2 0.7 1.6 0.4 0.6 0.3 0.4 0.3 1.1 0.3 0.1 0.7 6.2 0.4 0.7 1.0 0.6 1.3 0.7 0.9 0.7 0.8 0.8 0.6 1.2 0.8 1.1 3.2 0.5 1.6 5.5 6.2 3.9 5.8 5.2 1.7 3.9 6.0 4.6 32.9 4.1 7.3 0.0 17.3 6.0 4.5 3.9 3.4 7.8 5.5 8.0 3.5 1.8 34.5 3.3 1.1 35.6 5.3 6.1 9.9 0.0 21.1 3.6 1.2 11.1 0.0 2.5 9.2 2.0 0.0 5.2 3.1 1.5 3.2 0.0 2.8 3.2 2.8 3.1 1.5 1.6 2.9 3.9 1.2 17.7 3.1 8.0 9.4 2.5 1.7 0.0 3.1 7.8 48.9 49.8 9.5 4.8 7.8 5.1 4.8 16.7 3.0 CHEK2 "bA444G7, CDS1, CHK2, HuCds1, PP1425, RAD53" ENSG00000183765 "Checkpoint kinase 2" O96017 22 28687743-28742422 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Cell cycle, Cell division, DNA damage, DNA repair, Mitosis, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Li-Fraumeni syndrome, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Spermatogonia: 31.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA001878, CAB002030" Enhanced Supported "Nucleoplasm,Golgi apparatus" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "Golgi apparatus" "CAB002030: AB_563660, HPA001878: AB_1078514" "unprognostic (1.54e-1)" "unprognostic (2.20e-1)" "unprognostic (5.83e-2)" "unprognostic (2.93e-2)" "unprognostic (2.42e-1)" "unprognostic (3.83e-2)" "unprognostic (1.49e-3)" "unprognostic (5.08e-3)" "unprognostic (3.33e-3)" "unprognostic (9.62e-3)" "unprognostic (1.28e-2)" "unprognostic (3.13e-1)" "prognostic unfavorable (7.80e-9)" "unprognostic (2.38e-2)" "unprognostic (1.78e-1)" "unprognostic (7.27e-2)" "unprognostic (6.79e-3)" 4.5 6.2 2.4 8.8 2.5 15.4 5.8 2.4 3.7 5.0 2.8 8.8 6.3 4.1 7.3 7.2 3.7 4.7 4.2 2.3 2.8 4.5 6.3 4.4 12.1 2.6 2.6 8.2 2.3 1.3 2.7 7.8 2.8 4.1 10.9 0.4 3.2 3.8 1.3 6.7 7.0 4.8 2.6 6.7 4.1 8.5 2.8 9.4 3.3 1.1 12.0 6.8 5.0 2.9 30.7 9.7 31.1 32.4 10.1 42.7 18.7 15.2 19.9 18.7 27.8 29.1 21.8 36.3 13.0 11.5 21.6 32.1 42.7 29.0 25.0 24.6 31.2 45.3 25.5 46.2 9.4 33.4 38.0 18.6 13.5 25.0 23.0 14.1 25.4 29.4 30.5 33.9 19.8 39.2 24.6 61.5 40.6 41.3 21.6 52.6 18.2 42.7 17.1 11.2 17.8 9.7 16.7 31.4 17.4 22.8 22.6 32.2 7.8 17.1 19.4 14.3 9.1 21.8 28.3 65.4 17.1 34.9 21.0 9.9 4.0 1.2 1.1 8.1 2.4 11.9 2.1 2.1 8.2 7.8 4.0 2.6 0.6 3.4 4.1 6.1 2.8 3.6 2.4 2.5 2.4 3.7 2.3 2.8 2.6 2.6 2.8 2.6 2.8 2.9 2.3 9.6 4.8 2.9 5.5 6.4 5.3 8.3 8.6 1.1 3.2 3.9 1.8 0.0 5.0 1.8 0.0 15.4 1.1 3.8 0.0 1.8 7.0 2.9 10.1 3.0 1.2 11.2 2.9 1.4 13.6 12.4 5.1 7.0 3.8 7.4 2.5 1.3 9.7 0.0 1.2 5.3 8.2 2.4 8.5 1.2 6.2 5.1 1.8 2.8 3.9 0.8 6.2 0.0 1.0 1.0 4.7 4.5 11.4 2.7 3.0 3.9 2.9 1.1 0.0 10.2 3.0 6.7 31.2 8.3 2.3 3.4 3.3 5.7 10.0 4.5 CHFR "FLJ10796, RNF196" ENSG00000072609 "Checkpoint with forkhead and ring finger domains" Q96EP1 12 132822187-132956304 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 93.8;Late spermatids: 89.1;Rod photoreceptor cells: 117.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045768, HPA073826" Approved Uncertain "Nuclear bodies,Microtubules" NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 15: RT4 - Unknown function" "Cluster 9: Photoreceptor cells - Phototransduction" "Nuclear bodies, Microtubules" "HPA045768: , HPA073826: AB_2732242" "unprognostic (1.46e-1)" "unprognostic (2.11e-2)" "unprognostic (1.41e-1)" "unprognostic (3.86e-2)" "unprognostic (2.08e-1)" "unprognostic (2.14e-3)" "unprognostic (6.56e-4)" "unprognostic (1.94e-2)" "unprognostic (2.36e-2)" "unprognostic (1.25e-1)" "unprognostic (1.00e-2)" "unprognostic (3.98e-3)" "prognostic unfavorable (4.21e-9)" "unprognostic (5.03e-1)" "unprognostic (8.46e-2)" "unprognostic (6.71e-2)" "unprognostic (1.11e-2)" 9.8 8.1 7.8 15.6 7.9 22.0 9.1 7.1 9.1 9.8 6.0 12.4 15.9 10.7 3.3 15.6 8.7 9.9 10.7 6.9 7.0 8.6 9.0 12.2 20.9 7.9 7.3 6.2 11.9 7.6 9.4 17.7 7.9 9.9 8.5 6.3 9.4 9.6 8.0 12.3 15.0 12.6 6.0 17.5 12.9 15.4 8.6 25.2 9.1 9.2 13.8 14.4 10.8 9.1 11.0 24.1 19.3 1.6 16.8 21.3 41.0 23.4 17.9 23.7 22.7 20.6 8.7 0.2 21.6 25.3 16.7 18.6 2.1 21.5 12.2 1.3 21.0 36.5 16.7 24.4 42.0 1.2 67.5 32.4 20.0 19.6 13.5 15.5 30.1 2.8 15.9 0.0 16.7 40.4 24.5 25.3 27.4 20.9 19.8 2.9 2.5 11.4 15.3 49.4 20.8 28.2 18.2 20.0 17.8 22.5 34.4 36.2 33.3 1.2 4.7 11.8 7.7 37.0 0.1 4.2 0.0 6.8 21.7 38.3 25.5 35.5 16.7 29.6 15.8 10.5 13.2 17.8 20.7 6.4 12.0 13.3 34.8 23.2 31.5 10.6 21.5 19.3 7.8 7.9 7.1 9.1 6.9 7.0 7.9 7.3 7.9 6.0 8.6 9.1 11.2 12.8 19.5 20.5 17.2 6.1 7.9 6.0 4.6 22.1 8.2 5.7 9.9 4.3 15.3 7.3 93.8 12.3 29.4 17.9 9.8 10.2 53.0 11.1 14.3 13.1 21.1 13.0 33.4 13.8 15.7 10.8 28.1 12.2 66.4 14.4 11.4 7.7 19.4 21.9 32.0 10.2 14.2 21.7 9.3 89.1 7.5 22.0 10.6 24.4 29.4 8.8 40.2 18.1 31.3 16.9 11.4 8.6 24.2 11.2 11.7 4.4 10.8 117.9 19.7 9.2 10.7 19.0 24.6 11.1 9.7 23.7 24.2 16.1 8.6 13.8 CHKA "CHK, CKI" ENSG00000110721 "Choline kinase alpha" P35790 11 68052859-68121444 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 179.6;Early spermatids: 357.3;Late spermatids: 267.3;Oligodendrocytes: 203.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "eosinophil: 6.1" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "SK-MEL-30: 183.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA024153, CAB072803" Approved Approved "Endoplasmic reticulum" NA Yes "Cluster 52: Eosinophils - Transcription" "Cluster 43: Testis - Unknown function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 34: Spermatids - Unknown function" "Endoplasmic reticulum" "CAB072803: , HPA024153: AB_1846664" "unprognostic (5.16e-2)" "unprognostic (1.46e-1)" "unprognostic (2.52e-1)" "unprognostic (2.51e-1)" "unprognostic (2.66e-1)" "unprognostic (2.81e-1)" "prognostic unfavorable (7.75e-4)" "unprognostic (2.36e-3)" "unprognostic (1.66e-3)" "unprognostic (1.67e-2)" "unprognostic (1.33e-1)" "unprognostic (1.99e-1)" "unprognostic (5.97e-3)" "unprognostic (5.00e-2)" "unprognostic (6.06e-2)" "unprognostic (1.82e-1)" "unprognostic (4.73e-2)" 17.0 35.8 49.4 7.1 54.2 33.8 20.9 51.8 57.8 18.3 53.5 25.8 21.6 12.2 20.5 6.2 13.2 10.3 14.5 49.5 50.7 23.9 43.3 17.8 9.0 56.6 53.6 20.1 38.0 8.0 21.6 5.2 61.5 31.0 12.8 21.1 44.9 16.4 8.3 8.7 23.1 5.4 51.0 30.0 40.0 75.5 54.0 5.7 43.6 4.5 5.5 19.4 9.3 71.7 25.6 21.3 24.2 24.1 8.0 6.1 24.5 7.7 13.6 22.5 14.4 92.2 70.5 18.9 27.4 12.4 23.2 16.2 34.4 5.6 18.5 8.7 12.1 23.8 29.6 106.9 22.9 25.6 12.5 11.0 9.4 10.0 4.8 12.3 12.7 11.9 23.1 34.7 12.0 19.4 14.6 68.4 40.1 83.2 14.2 21.3 26.1 54.6 18.1 27.3 17.9 19.6 14.9 74.6 183.8 19.9 31.6 34.4 7.3 14.2 16.3 32.4 10.4 37.0 42.5 34.4 14.6 32.8 13.0 0.0 0.8 6.1 0.1 1.5 0.0 0.7 0.1 0.2 0.9 0.3 0.4 0.2 0.4 1.1 0.9 0.7 0.2 0.2 49.4 54.2 51.8 57.8 49.5 50.7 56.6 53.6 61.5 51.0 54.0 71.7 27.2 44.8 36.6 179.6 10.1 15.8 16.6 6.5 18.2 10.6 49.4 35.7 3.6 35.8 20.2 3.7 33.3 8.2 14.2 48.1 13.7 9.6 357.3 42.7 16.2 13.6 28.1 6.7 89.0 19.3 3.4 9.2 37.2 59.0 19.0 23.4 11.7 19.8 17.6 57.2 63.2 16.3 0.0 28.5 19.4 267.3 6.2 31.0 23.2 59.0 8.5 21.4 2.1 100.0 203.5 18.4 18.0 2.6 10.1 17.3 21.6 4.6 23.1 28.4 0.0 9.6 9.8 121.9 20.7 9.2 10.4 13.0 8.2 16.9 31.7 39.2 CHKB "CHETK, CHKL" ENSG00000100288 "Choline kinase beta" Q9Y259 22 50578959-50601455 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Kinase, Transferase" "Congenital muscular dystrophy, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "monocytes: 48.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HHSteC: 19.1;RPMI-8226: 19.8" HPA018797 Approved Approved Cytosol NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 35: Non-specific - Unknown function" "Cluster 25: RPMI-8226 - Immune response" "Cluster 3: Monocytes - Immune response regulation" Cytosol "HPA018797: AB_1846666" "unprognostic (6.03e-4)" "prognostic favorable (4.66e-4)" "unprognostic (4.31e-2)" "unprognostic (2.63e-2)" "unprognostic (2.14e-1)" "unprognostic (1.42e-2)" "unprognostic (3.25e-3)" "unprognostic (1.70e-2)" "unprognostic (2.00e-1)" "unprognostic (7.84e-2)" "unprognostic (5.23e-3)" "unprognostic (5.43e-2)" "prognostic unfavorable (1.56e-5)" "unprognostic (1.33e-1)" "unprognostic (9.54e-2)" "unprognostic (1.30e-2)" "unprognostic (2.18e-3)" 14.1 13.0 10.3 0.7 10.3 12.1 13.4 10.5 16.8 10.6 12.2 10.5 3.3 9.5 12.0 11.1 12.0 1.5 11.5 10.1 10.8 13.2 9.4 13.3 4.3 10.5 11.0 8.6 7.7 17.7 14.3 7.2 10.6 12.0 4.8 1.6 11.9 7.2 8.3 11.6 10.7 5.3 10.7 18.1 11.6 14.5 11.0 9.2 12.6 11.7 9.8 11.7 11.1 10.8 4.2 1.3 0.5 1.6 6.7 5.9 10.8 7.3 16.7 4.7 3.1 1.4 2.1 2.1 4.2 3.8 2.4 0.0 1.5 2.0 1.0 0.3 5.4 3.1 2.2 2.3 19.1 2.5 4.8 2.0 6.5 0.6 8.1 4.5 17.1 5.5 1.8 0.3 12.4 5.3 2.0 8.6 0.7 7.0 1.9 3.5 1.8 19.8 11.5 2.0 2.0 3.2 3.0 7.3 5.9 0.2 1.1 2.8 6.9 0.0 1.7 0.0 2.2 7.4 0.0 3.0 2.3 0.4 3.4 12.0 39.5 27.0 26.4 38.4 25.7 24.0 24.2 27.6 35.7 23.6 22.6 20.8 9.6 37.0 26.1 34.1 33.4 32.6 10.3 10.3 10.5 16.8 10.1 10.8 10.5 11.0 10.6 10.7 11.0 10.8 16.7 6.4 28.2 0.0 13.6 4.8 2.3 6.9 8.6 4.8 10.0 7.4 7.7 20.0 12.7 7.3 4.2 8.8 14.0 18.4 3.9 30.6 11.6 3.9 3.4 8.0 15.7 9.0 0.0 23.8 14.1 8.6 19.9 3.3 19.0 2.5 10.4 5.4 14.6 8.4 0.0 19.3 12.2 16.6 9.2 30.5 2.5 10.0 3.6 0.0 48.4 3.3 14.4 0.0 0.0 23.5 24.2 3.0 14.6 2.1 29.3 5.5 11.2 6.0 6.6 2.4 6.8 12.6 10.0 14.5 6.3 8.5 11.2 2.8 17.3 2.2 CHPF "CHSY2, CSS2" ENSG00000123989 "Chondroitin polymerizing factor" Q8IZ52 2 219538948-219543809 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 163.7;Extravillous trophoblasts: 182.7;Syncytiotrophoblasts: 310.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "plasmacytoid DC: 9.5" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA035123 Approved Supported Vesicles,Centrosome,Cytosol "Intracellular and membrane" NA NA 570000 "Cluster 52: Eosinophils - Transcription" "Cluster 29: Non-specific - Vesicular transport" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 55: Plasma cells - Humoral immune response" Cytosol "Vesicles, Centrosome" "HPA035123: AB_10602799" "unprognostic (1.13e-3)" "prognostic unfavorable (1.57e-4)" "unprognostic (3.65e-3)" "unprognostic (2.55e-3)" "unprognostic (1.86e-3)" "prognostic unfavorable (1.68e-4)" "unprognostic (1.37e-1)" "unprognostic (6.59e-3)" "unprognostic (7.74e-2)" "unprognostic (1.19e-2)" "unprognostic (1.18e-1)" "unprognostic (6.79e-2)" "unprognostic (1.64e-1)" "unprognostic (6.55e-2)" "unprognostic (1.82e-1)" "unprognostic (1.17e-1)" "prognostic unfavorable (2.96e-4)" 29.9 45.7 26.9 12.5 24.9 1.7 22.3 25.8 34.2 59.1 36.7 21.9 26.7 55.9 13.7 27.3 30.2 24.2 134.8 38.4 31.2 41.1 97.8 42.8 6.5 34.0 30.4 127.4 138.9 24.6 128.3 40.6 32.1 58.6 4.7 8.5 56.1 25.6 16.3 26.2 23.2 12.6 27.4 16.6 40.9 97.5 33.2 3.6 52.8 3.9 4.5 34.3 30.0 34.0 67.5 13.0 9.6 81.0 36.0 55.8 109.7 66.4 55.4 18.5 16.8 36.8 57.5 20.7 139.0 64.6 63.3 84.1 6.3 40.3 2.9 32.3 22.5 7.4 18.0 161.9 49.8 6.6 42.1 75.0 69.2 18.8 17.9 66.7 0.1 7.1 47.2 49.6 17.7 105.5 1.0 17.6 39.8 22.8 50.6 0.1 30.4 41.6 22.4 29.7 23.4 36.0 32.1 30.7 94.3 17.9 10.5 22.6 1.6 67.9 37.1 81.9 35.2 58.9 19.9 9.7 62.1 6.7 70.4 1.7 0.0 6.5 1.9 0.1 2.4 1.0 1.5 1.3 0.0 0.1 1.7 0.6 0.0 1.9 0.0 9.5 1.2 0.7 26.9 24.9 25.8 34.2 38.4 31.2 34.0 30.4 32.1 27.4 33.2 34.0 2.1 0.0 15.2 16.0 16.5 14.5 23.2 52.8 17.1 14.6 40.0 29.6 30.5 22.8 31.2 75.4 10.4 163.7 21.7 15.9 9.8 58.1 4.1 14.0 22.2 2.9 43.0 3.2 4.3 80.4 182.7 56.0 25.5 42.4 10.2 27.4 4.2 64.0 18.5 43.7 9.2 57.8 36.7 2.4 9.1 7.1 24.8 2.3 67.6 5.6 1.8 56.8 9.2 5.5 3.7 65.6 32.7 63.2 123.6 42.3 60.7 20.6 14.6 11.5 26.3 19.3 27.1 11.9 6.3 14.2 11.1 310.3 9.7 46.3 14.3 33.0 CHPF2 "ChSy-3, CSGlcA-T, KIAA1402" ENSG00000033100 "Chondroitin polymerizing factor 2" Q9P2E5 7 151232489-151238827 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA020992 Approved Approved Nucleoplasm,Cytosol "Intracellular and membrane" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 18: Non-specific - Mitochondria" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 55: Plasma cells - Humoral immune response" "Nucleoplasm, Cytosol" "HPA020992: AB_1847267" "unprognostic (8.31e-2)" "unprognostic (2.14e-3)" "unprognostic (1.02e-3)" "unprognostic (1.14e-1)" "unprognostic (4.79e-3)" "unprognostic (5.25e-2)" "prognostic unfavorable (9.47e-4)" "unprognostic (4.07e-1)" "unprognostic (1.71e-1)" "unprognostic (4.54e-2)" "prognostic favorable (2.51e-4)" "unprognostic (1.04e-1)" "unprognostic (2.68e-3)" "unprognostic (2.24e-1)" "unprognostic (1.49e-1)" "unprognostic (3.22e-2)" "unprognostic (8.59e-3)" 13.7 31.7 9.5 17.4 9.3 23.1 13.6 3.8 12.9 14.6 13.5 17.4 13.0 19.5 10.3 14.0 14.6 15.1 19.8 9.6 11.6 14.9 20.4 17.6 16.6 11.1 8.7 14.0 26.2 13.2 43.7 16.1 10.0 19.1 9.0 2.9 22.2 12.9 8.1 14.7 18.9 14.9 5.4 28.9 20.1 9.6 10.5 10.9 17.6 5.0 10.7 16.7 13.6 6.7 27.9 22.3 14.7 43.1 50.0 49.2 22.2 57.3 88.4 30.5 37.1 14.9 46.1 8.4 98.7 91.6 41.5 34.3 6.5 40.8 13.1 32.1 20.3 8.9 25.4 21.0 46.7 18.2 70.9 75.8 22.7 28.9 10.3 63.1 48.6 13.8 8.6 23.7 49.2 45.7 17.0 70.6 19.7 11.6 25.6 15.8 8.7 28.1 29.6 21.7 15.9 28.1 30.7 29.8 15.2 11.0 11.6 29.4 66.9 33.6 5.6 45.2 49.3 43.3 6.8 12.3 122.3 23.9 46.6 0.9 4.4 6.2 4.0 3.6 3.7 1.9 2.1 3.6 4.7 2.0 1.4 1.6 7.2 2.0 3.9 6.9 2.4 3.3 9.5 9.3 3.8 12.9 9.6 11.6 11.1 8.7 10.0 5.4 10.5 6.7 8.3 9.6 11.8 2.3 11.2 4.6 6.6 15.1 6.2 8.8 10.5 5.6 1.9 10.0 11.7 11.0 4.2 11.5 23.4 21.3 1.9 12.4 0.6 6.5 11.0 8.9 8.4 8.6 6.1 16.8 16.3 13.3 18.8 9.0 6.3 14.6 12.5 9.6 12.6 25.2 5.0 12.0 14.2 10.9 6.8 1.0 17.1 11.1 7.2 3.7 11.0 5.3 11.3 5.5 1.8 17.7 17.4 15.1 26.5 11.5 8.5 3.5 8.8 7.4 19.7 7.8 14.6 5.0 3.1 6.6 4.4 10.3 13.0 15.8 9.8 10.5 CHPT1 CPT1 ENSG00000111666 "Choline phosphotransferase 1" Q8WUD6 12 101696947-101744140 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 344.4;Late spermatids: 650.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 6 "basophil: 36.9;eosinophil: 14.6" "Lineage enriched" "Detected in all" 8 "granulocytes: 36.9" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA067643 Approved Supported Vesicles NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 22: Epithelial cell types - Mixed function" Vesicles "HPA067643: " "unprognostic (1.59e-3)" "unprognostic (1.02e-1)" "unprognostic (1.91e-1)" "unprognostic (9.48e-2)" "unprognostic (3.15e-1)" "unprognostic (9.17e-2)" "unprognostic (5.79e-2)" "unprognostic (4.83e-2)" "unprognostic (1.12e-1)" "unprognostic (4.70e-1)" "unprognostic (5.27e-2)" "unprognostic (1.16e-2)" "unprognostic (1.52e-2)" "unprognostic (3.35e-1)" "unprognostic (1.72e-1)" "prognostic favorable (7.41e-4)" "unprognostic (1.79e-1)" 39.8 47.7 48.6 17.7 49.1 62.0 102.9 43.8 65.6 50.5 41.9 49.4 88.1 19.2 56.1 24.9 33.4 40.2 91.3 46.1 47.3 73.5 157.4 38.4 20.0 50.0 51.2 18.7 25.0 92.4 12.4 22.8 44.9 35.0 48.9 4.8 130.0 50.0 27.8 28.0 75.7 18.8 50.0 23.5 56.0 28.1 54.4 9.0 38.0 28.3 21.2 32.4 26.2 48.9 11.3 51.2 13.7 29.3 106.6 35.7 38.9 40.2 46.2 39.7 25.5 19.3 7.7 17.3 22.1 55.1 54.3 16.9 83.8 14.2 37.3 26.2 70.1 69.7 25.7 112.6 59.4 34.8 13.5 33.6 4.1 18.0 32.7 59.0 20.0 36.4 102.8 43.1 39.4 27.6 20.8 118.5 36.2 53.8 67.4 15.9 26.8 12.4 17.9 43.4 13.8 10.4 37.2 52.3 103.2 21.4 53.8 23.6 14.7 36.1 18.7 28.5 39.9 24.3 7.9 21.2 28.4 39.7 53.4 36.9 2.2 14.6 0.6 1.7 0.6 4.4 1.2 0.9 2.9 2.6 0.4 0.6 3.1 4.6 2.2 3.7 0.6 0.5 48.6 49.1 43.8 65.6 46.1 47.3 50.0 51.2 44.9 50.0 54.4 48.9 27.1 48.1 27.6 159.6 135.1 37.5 313.3 4.2 21.6 19.3 243.8 76.7 45.3 102.9 13.1 64.4 29.2 123.9 32.6 61.7 70.5 8.1 344.4 17.1 50.2 22.5 21.1 168.6 95.8 13.8 56.1 75.4 69.8 21.0 10.8 15.3 31.1 189.7 56.4 35.3 95.6 53.4 2.0 102.9 55.7 650.9 85.4 81.2 145.9 36.5 27.0 68.1 5.2 65.9 10.2 9.6 113.3 89.1 55.4 172.1 174.1 183.7 4.3 16.0 19.7 88.2 37.8 193.8 43.2 43.1 43.2 60.3 41.3 3.4 90.7 291.6 CHST1 "C6ST, KSGal6ST" ENSG00000175264 "Carbohydrate sulfotransferase 1" O43916 11 45647689-45665622 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Carbohydrate metabolism, Inflammatory response" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 35.6;thyroid gland: 20.5" "Cell type enhanced" "Detected in many" "Astrocytes: 38.5;Early spermatids: 75.9;Granulosa cells: 138.1;Spermatocytes: 96.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HUVEC TERT2: 9.3;TIME: 9.2;WM-115: 24.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "Intracellular and membrane" NA NA 10000 "Cluster 10: Brain - Neuronal signaling" "Cluster 17: WM-115 - Nervous system development" "Cluster 40: Granulosa cells - Unknown function" "unprognostic (1.77e-2)" "unprognostic (1.67e-1)" "unprognostic (6.37e-3)" "unprognostic (1.32e-1)" "unprognostic (2.18e-2)" "unprognostic (2.50e-1)" "prognostic unfavorable (3.95e-4)" "unprognostic (6.22e-2)" "unprognostic (1.64e-1)" "unprognostic (1.39e-1)" "unprognostic (1.09e-1)" "unprognostic (2.10e-1)" "prognostic unfavorable (4.64e-7)" "unprognostic (5.37e-3)" "unprognostic (1.06e-1)" "unprognostic (1.30e-1)" "unprognostic (9.11e-3)" 2.3 3.7 31.4 0.5 34.2 0.3 1.9 0.4 35.6 2.7 0.0 1.8 0.5 2.3 0.1 1.0 5.5 0.6 5.7 32.6 13.4 8.7 2.1 4.5 0.7 6.9 12.7 5.3 1.3 3.3 11.9 0.4 6.8 2.0 0.1 1.0 6.4 0.3 8.7 1.1 1.6 0.5 2.4 7.6 1.5 4.0 24.2 0.5 20.5 1.0 0.4 2.0 2.1 16.4 0.0 0.3 0.7 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 3.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.1 2.0 0.0 0.0 0.2 0.3 9.3 0.1 0.0 0.1 0.8 0.2 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.1 0.0 0.0 0.5 0.7 0.2 0.0 9.2 1.8 2.6 0.0 0.0 0.0 0.0 0.0 3.8 0.0 24.8 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 31.4 34.2 0.4 35.6 32.6 13.4 6.9 12.7 6.8 2.4 24.2 16.4 4.4 0.0 0.0 38.5 0.0 0.1 2.9 0.4 0.0 10.0 1.4 0.4 2.1 0.0 0.3 1.8 0.0 0.0 0.2 0.0 0.0 2.6 75.9 0.7 1.1 21.1 0.0 0.0 23.9 0.2 0.1 2.3 0.5 2.5 0.0 138.1 10.4 0.3 0.2 0.0 10.2 0.0 0.0 0.9 1.7 15.0 5.6 0.9 0.0 4.7 0.0 4.5 0.0 3.0 3.9 0.3 0.0 4.9 0.0 2.4 0.0 0.1 0.2 0.5 26.3 0.7 2.6 96.8 1.4 0.2 0.0 0.0 0.5 2.3 0.0 0.9 CHST11 "C4ST, C4St-1, C4ST1, HSA269537" ENSG00000171310 "Carbohydrate sulfotransferase 11" Q9NPF2 12 104455295-104762014 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Carbohydrate metabolism" Transferase "Disease variant, Dwarfism" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 39.0;choroid plexus: 59.1" "Group enriched" "Detected in many" 4 "Microglial cells: 281.1;Oligodendrocyte precursor cells: 1012.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "basophil: 12.7;eosinophil: 11.2;neutrophil: 15.6" "Lineage enriched" "Detected in all" 5 "granulocytes: 15.6" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA052828 Approved Approved "Golgi apparatus" "Intracellular and membrane" NA NA 55000 "Cluster 5: Granulocytes - Unknown function" "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 24: NB-4 - Immune response" "Cluster 68: Oligodendrocytes - Mixed function" "Golgi apparatus" "HPA052828: AB_2681966" "unprognostic (6.35e-2)" "unprognostic (2.68e-3)" "unprognostic (2.28e-2)" "unprognostic (7.53e-2)" "unprognostic (3.45e-2)" "unprognostic (2.64e-2)" "unprognostic (1.64e-3)" "unprognostic (9.21e-3)" "unprognostic (3.12e-1)" "unprognostic (9.02e-2)" "unprognostic (1.22e-2)" "unprognostic (5.44e-2)" "prognostic unfavorable (7.59e-11)" "unprognostic (1.64e-2)" "unprognostic (5.60e-2)" "unprognostic (5.40e-3)" "prognostic unfavorable (8.42e-4)" 5.0 10.2 14.5 20.1 13.9 39.0 3.5 11.1 14.1 5.6 59.1 4.2 3.0 11.9 13.3 3.4 3.7 9.4 4.5 15.0 16.0 3.6 3.0 12.2 15.2 17.9 16.4 6.2 4.6 1.3 4.5 15.5 17.1 3.9 4.0 2.2 2.2 8.0 1.1 1.7 6.2 10.9 13.1 12.8 6.3 2.3 17.3 19.5 3.3 1.0 11.7 8.3 3.8 17.5 38.8 18.2 8.2 5.3 20.5 10.0 27.8 3.1 1.2 1.8 1.5 0.0 51.2 0.2 5.6 5.4 42.3 9.9 4.9 20.8 2.2 0.4 7.1 53.2 4.8 0.2 3.1 62.4 60.6 3.7 2.9 32.9 5.4 30.7 13.2 74.4 82.8 13.2 3.5 9.7 47.8 73.1 6.6 0.4 7.0 54.0 27.3 12.9 17.0 0.4 13.6 21.9 2.1 26.3 48.3 7.2 7.7 62.7 29.2 5.7 6.2 29.4 32.3 67.2 75.9 10.6 26.3 43.5 57.7 12.7 1.4 11.2 3.0 1.4 1.7 1.0 1.5 2.2 0.8 2.8 0.7 1.9 15.6 1.6 1.3 2.9 3.2 0.8 14.5 13.9 11.1 14.1 15.0 16.0 17.9 16.4 17.1 13.1 17.3 17.5 8.4 16.0 13.1 142.4 33.8 2.8 18.2 2.6 4.0 3.1 0.5 1.1 5.7 1.5 6.4 5.5 0.0 41.6 45.6 0.1 0.0 4.9 0.9 1.3 24.7 12.9 0.0 36.2 43.8 61.4 12.0 9.5 2.6 0.9 41.3 1.4 18.2 0.5 42.6 10.1 114.4 0.0 0.0 26.8 42.9 2.0 7.5 56.5 3.6 281.1 65.6 2.3 30.9 1012.8 3.5 28.6 0.0 17.0 64.0 3.9 0.0 6.0 8.1 0.6 6.6 1.8 12.8 0.6 2.5 0.9 2.8 26.5 49.0 15.5 0.3 3.7 CHST12 "C4S-2, C4ST2" ENSG00000136213 "Carbohydrate sulfotransferase 12" Q9NRB3 7 2403588-2448484 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Carbohydrate metabolism" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "dendritic cells: 158.7;Hepatic stellate cells: 152.8;NK-cells: 368.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HMC-1: 60.1;NB-4: 57.4;U-266/70: 88.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041680 Approved Approved "Golgi apparatus" NA NA 960000 "Cluster 48: NK-cells - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 24: NB-4 - Immune response" "Cluster 63: NK-cells & T-cells - Immune response" "Golgi apparatus" "HPA041680: AB_10959789" "unprognostic (4.12e-2)" "unprognostic (3.56e-1)" "unprognostic (3.04e-3)" "unprognostic (1.59e-1)" "unprognostic (2.05e-3)" "unprognostic (7.15e-2)" "unprognostic (2.01e-3)" "unprognostic (1.34e-1)" "unprognostic (3.20e-2)" "unprognostic (4.88e-2)" "prognostic favorable (1.32e-5)" "unprognostic (9.61e-2)" "unprognostic (1.66e-3)" "unprognostic (4.90e-2)" "unprognostic (2.26e-1)" "unprognostic (1.95e-1)" "unprognostic (1.55e-1)" 16.1 13.3 4.5 5.1 3.5 6.1 15.0 7.3 5.0 15.4 0.2 13.7 5.4 17.8 0.6 7.9 15.8 1.2 15.5 9.0 2.6 11.3 7.1 14.5 2.9 9.4 4.7 11.6 11.7 1.4 17.6 2.8 4.6 13.6 0.6 1.2 10.3 2.8 8.3 15.6 10.6 1.4 3.8 24.5 11.1 9.1 5.9 1.4 14.1 0.9 1.0 13.1 13.1 4.3 9.5 9.1 2.7 10.0 3.8 2.3 29.5 17.2 4.2 4.2 5.7 9.0 3.2 8.5 31.6 2.7 10.3 7.1 1.6 2.2 0.8 11.2 17.7 5.9 7.0 9.9 2.6 19.4 60.1 4.8 0.9 3.8 0.5 3.3 4.2 11.5 15.1 25.0 1.2 6.8 19.8 57.4 19.1 1.3 14.4 7.1 7.6 42.1 1.2 3.8 6.8 28.7 8.4 4.5 4.0 2.0 6.6 22.3 13.0 9.6 26.5 20.0 15.2 88.9 37.1 3.9 7.8 8.8 17.9 59.1 10.4 53.2 87.6 9.1 54.4 14.7 30.0 71.4 20.4 18.3 12.6 37.8 3.1 121.6 3.9 64.9 33.0 22.9 4.5 3.5 7.3 5.0 9.0 2.6 9.4 4.7 4.6 3.8 5.9 4.3 36.8 16.0 50.5 9.1 32.8 18.1 35.5 24.3 18.8 45.6 18.0 13.0 8.3 15.7 30.5 18.4 66.7 104.5 158.7 6.2 1.9 22.4 6.7 4.7 21.1 59.4 12.7 37.0 11.0 15.3 15.0 37.0 6.1 6.4 38.0 13.4 152.8 7.2 24.8 47.1 12.3 9.1 24.4 26.4 22.9 5.8 95.7 21.2 21.4 10.3 21.3 15.1 368.7 14.1 9.5 13.3 6.7 67.7 107.8 18.4 16.2 9.5 15.2 50.5 19.7 25.6 17.9 37.8 30.6 9.2 15.3 133.5 93.2 18.4 12.2 13.1 CHST13 C4ST3 ENSG00000180767 "Carbohydrate sulfotransferase 13" Q8NET6 3 126524155-126543291 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Carbohydrate metabolism" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 11 "liver: 59.6;testis: 18.3" "Group enriched" "Detected in some" 5 "Early spermatids: 104.0;Hepatocytes: 40.3;Spermatocytes: 126.2" "Group enriched" "Detected in many" 4 "liver cancer: 25.0;renal cancer: 6.3" "Not detected" "Not detected" "Immune cell enriched" "Detected in many" 5 "eosinophil: 155.2" "Lineage enriched" "Detected in many" 5 "granulocytes: 155.2" "Group enriched" "Detected in some" 8 "CACO-2: 15.6;Hep G2: 28.4;NB-4: 19.0;THP-1: 11.2" "Not detected" "Not detected" "Low region specificity" "Detected in single" HPA067960 Approved "Golgi apparatus" "Intracellular and membrane" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 62: Liver - Hemostasis" "Cluster 39: CACO-2 - Unknown function" "Cluster 66: Spermatocytes - Spermatogenesis" "Golgi apparatus" "HPA067960: " "unprognostic (5.68e-2)" "unprognostic (1.21e-1)" "unprognostic (1.32e-2)" "unprognostic (6.42e-4)" "unprognostic (2.26e-1)" "unprognostic (1.05e-1)" "unprognostic (8.45e-3)" "unprognostic (1.40e-1)" "unprognostic (2.04e-1)" "unprognostic (1.52e-1)" "unprognostic (2.13e-1)" "unprognostic (1.98e-1)" "unprognostic (5.75e-2)" "unprognostic (5.16e-2)" "unprognostic (6.68e-2)" "unprognostic (2.26e-1)" "unprognostic (1.59e-2)" 0.3 0.4 0.2 0.4 0.2 0.6 0.1 0.0 0.3 0.1 0.0 0.9 0.6 0.1 0.0 0.0 0.2 0.0 0.4 0.3 0.2 3.2 59.6 0.6 0.1 0.4 0.5 0.0 0.1 0.0 0.1 0.0 0.2 0.1 0.1 0.0 0.1 0.0 0.0 0.1 1.0 0.0 0.4 3.5 0.4 18.3 0.6 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.6 0.7 0.0 2.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.6 0.7 0.3 28.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.0 0.9 0.5 0.0 0.0 0.0 0.5 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 11.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 7.1 33.0 155.2 0.0 20.5 0.0 0.0 0.0 0.0 22.0 0.0 0.0 0.0 30.7 0.0 17.5 0.0 0.0 13.1 0.2 0.2 0.0 0.3 0.3 0.2 0.4 0.5 0.2 0.4 0.6 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 10.0 0.0 0.0 0.0 0.1 0.0 1.1 0.0 0.0 104.0 0.6 0.0 0.1 1.2 5.5 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.3 0.7 40.3 13.1 0.0 0.0 1.0 0.0 7.5 1.3 16.9 1.5 6.2 0.0 1.9 7.2 0.0 0.0 0.0 0.1 0.0 2.8 1.2 0.3 0.0 8.5 9.9 0.1 0.0 0.0 0.0 0.0 126.2 2.8 0.0 0.0 0.3 0.2 0.0 1.8 0.0 CHST14 "D4ST-1, D4ST1, HD4ST" ENSG00000169105 "Carbohydrate sulfotransferase 14" Q8NCH0 15 40470984-40473158 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Carbohydrate metabolism" Transferase "Disease variant, Ehlers-Danlos syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 46.5;Extravillous trophoblasts: 32.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 7.6" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA057697, HPA071601" Enhanced Approved "Golgi apparatus" NA NA 20000 "Cluster 34: Basophils - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 47: Cytotrophoblasts - Unknown function" "Golgi apparatus" "HPA057697: AB_2683505, HPA071601: AB_2686425" "unprognostic (5.46e-2)" "unprognostic (9.23e-2)" "unprognostic (4.03e-2)" "unprognostic (2.63e-3)" "unprognostic (1.44e-1)" "unprognostic (1.86e-1)" "unprognostic (2.96e-2)" "unprognostic (6.94e-2)" "unprognostic (1.70e-1)" "unprognostic (9.95e-2)" "unprognostic (2.84e-1)" "unprognostic (3.17e-2)" "unprognostic (5.85e-3)" "unprognostic (2.01e-3)" "unprognostic (1.94e-1)" "unprognostic (6.34e-2)" "unprognostic (2.25e-2)" 14.2 9.6 6.8 7.7 7.5 3.4 13.7 7.0 6.5 22.0 7.3 11.8 4.5 21.6 8.0 8.7 16.5 11.3 13.8 6.2 7.0 10.1 8.8 13.0 8.5 8.0 7.1 21.1 8.1 11.3 14.4 27.0 7.2 14.6 4.6 1.6 11.0 15.4 5.0 9.1 9.9 12.6 7.5 13.6 9.4 7.9 7.0 8.6 15.8 7.4 7.5 16.1 16.1 7.3 26.2 17.1 26.4 71.6 40.4 31.0 43.0 25.2 47.3 43.5 40.9 21.2 12.8 4.3 37.6 42.7 76.7 43.7 23.7 14.2 20.3 31.5 15.0 13.4 16.9 19.8 22.5 5.7 33.4 38.3 11.6 15.4 11.6 47.8 39.2 15.1 13.6 15.0 32.6 20.1 9.6 29.8 17.0 7.9 20.1 26.2 33.4 7.6 29.5 13.3 19.7 30.2 22.2 24.4 8.4 31.9 35.7 23.9 31.9 73.0 27.1 23.3 25.5 30.3 22.6 12.2 32.8 19.6 53.7 7.6 1.1 2.2 2.2 1.1 0.6 0.3 1.1 1.9 2.0 1.1 0.9 0.8 0.1 3.3 0.6 0.7 0.8 0.7 6.8 7.5 7.0 6.5 6.2 7.0 8.0 7.1 7.2 7.5 7.0 7.3 10.6 12.8 1.1 2.0 5.8 3.4 5.4 4.1 9.1 0.6 5.8 9.7 3.2 7.2 4.6 3.7 0.0 46.5 3.5 0.5 0.0 7.7 1.8 3.2 14.5 10.2 2.4 10.7 0.1 4.9 32.4 19.3 0.0 5.6 4.5 14.9 15.4 3.7 9.3 1.7 0.1 1.4 2.0 5.6 3.3 1.3 17.7 5.6 5.4 2.8 3.4 9.8 6.2 2.0 0.5 5.2 0.3 11.7 1.9 3.6 0.2 1.1 3.0 0.8 6.6 11.8 9.2 7.5 1.3 5.6 2.6 13.5 4.9 3.9 1.9 1.3 CHST15 "BRAG, GALNAC4S-6ST, KIAA0598" ENSG00000182022 "Carbohydrate sulfotransferase 15" Q7LFX5 10 124007668-124093598 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Kupffer cells: 50.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 69.0" "Group enriched" "Detected in many" 11 "granulocytes: 69.0;monocytes: 38.7" "Cell line enhanced" "Detected in many" "Karpas-707: 66.0;REH: 90.4;U-266/70: 59.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017584 Approved Approved Centrosome,Cytosol NA NA 690000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 64: Macrophages - Immune response" "Cluster 29: U-266 - Adaptive immune response" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Cytosol Centrosome "HPA017584: AB_1849437" "unprognostic (1.19e-1)" "unprognostic (2.29e-2)" "unprognostic (1.32e-1)" "unprognostic (1.72e-2)" "unprognostic (4.12e-2)" "unprognostic (1.18e-2)" "unprognostic (1.90e-1)" "unprognostic (3.02e-2)" "unprognostic (2.40e-2)" "unprognostic (7.62e-3)" "unprognostic (7.90e-2)" "unprognostic (8.16e-2)" "prognostic unfavorable (2.22e-7)" "unprognostic (6.47e-3)" "unprognostic (7.80e-2)" "unprognostic (4.63e-3)" "unprognostic (5.26e-3)" 17.0 10.4 9.3 19.8 25.4 7.0 11.4 5.3 14.6 10.6 23.8 19.8 9.8 7.9 8.3 9.4 15.0 12.8 5.5 17.2 6.0 9.6 13.6 17.2 17.8 8.3 8.2 37.0 14.1 2.8 8.4 6.6 6.7 9.7 8.8 2.8 9.4 13.8 13.7 9.2 15.4 10.6 10.2 36.7 11.5 4.3 9.5 9.3 19.8 5.8 14.2 12.4 9.2 11.6 32.3 21.2 7.8 1.7 7.5 4.0 0.1 6.4 8.6 3.4 4.9 0.6 17.1 0.0 20.1 26.4 2.3 35.9 1.5 20.8 2.9 0.2 5.9 0.1 9.3 16.0 2.4 0.0 39.2 2.5 23.5 9.5 8.0 8.3 6.9 0.1 0.0 66.0 17.0 18.0 0.1 0.1 6.8 4.9 0.1 90.4 10.6 21.6 17.1 3.1 0.8 1.7 17.1 9.6 0.0 19.3 7.0 0.1 8.3 0.9 0.3 24.3 1.0 59.5 15.7 16.9 0.2 0.0 0.1 0.0 21.8 15.3 0.0 33.3 0.0 4.5 0.0 0.0 4.2 4.4 0.3 0.0 69.0 0.0 38.7 4.9 0.3 9.1 9.3 25.4 5.3 14.6 17.2 6.0 8.3 8.2 6.7 10.2 9.5 11.6 14.3 22.4 9.6 4.2 13.5 16.8 16.1 15.3 2.2 5.6 10.5 5.2 2.2 12.8 12.1 20.2 0.0 1.8 7.2 0.1 0.0 9.7 29.5 7.4 5.9 18.2 1.8 0.0 43.8 0.7 2.3 8.4 0.5 14.0 5.7 0.4 42.1 9.0 10.5 0.0 33.2 0.0 16.2 50.2 3.6 34.8 10.2 34.0 1.8 43.1 30.3 0.1 2.1 35.2 1.0 9.8 0.0 1.9 34.3 14.7 0.0 0.7 11.9 0.5 19.7 13.4 11.5 10.4 10.0 2.4 11.6 1.0 1.4 0.8 0.1 15.8 CHST3 "C6ST, C6ST1" ENSG00000122863 "Carbohydrate sulfotransferase 3" Q7LGC8 10 71964395-72013558 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Carbohydrate metabolism" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Granulosa cells: 26.9;Oligodendrocyte precursor cells: 26.7;Oligodendrocytes: 27.1;Skeletal myocytes: 26.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "U-251 MG: 65.1" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA047523, HPA055704" Enhanced Approved "Golgi apparatus,Cytosol" NA NA 690000 "Cluster 21: Non-specific - Transcription" "Cluster 20: HeLa - Mitochondria" "Cluster 40: Granulosa cells - Unknown function" "Golgi apparatus, Cytosol" "HPA047523: AB_2680075, HPA055704: AB_2682891" "unprognostic (1.10e-2)" "unprognostic (1.93e-1)" "unprognostic (1.13e-3)" "unprognostic (1.16e-3)" "unprognostic (2.44e-1)" "unprognostic (4.67e-2)" "unprognostic (4.79e-2)" "unprognostic (7.53e-2)" "unprognostic (7.99e-2)" "unprognostic (3.71e-2)" "unprognostic (2.83e-3)" "unprognostic (5.99e-2)" "unprognostic (1.40e-2)" "unprognostic (2.65e-2)" "unprognostic (7.77e-2)" "unprognostic (2.56e-2)" "unprognostic (2.54e-3)" 18.4 13.4 10.7 5.5 17.9 0.0 11.4 16.8 11.5 10.7 6.2 11.9 0.9 16.0 3.7 6.4 12.9 4.7 14.3 9.9 12.9 7.9 1.2 7.9 1.6 27.9 18.2 20.6 4.6 1.2 4.6 8.0 19.8 11.1 2.1 2.1 6.4 14.8 17.7 8.7 5.4 17.1 14.0 2.5 14.7 18.1 17.3 4.2 5.5 9.0 1.4 9.4 8.4 25.3 15.4 16.4 8.2 20.3 36.6 14.4 0.3 32.0 30.4 19.3 12.8 14.4 30.1 0.0 21.4 37.9 15.5 19.7 7.4 21.9 15.3 0.4 5.5 0.1 27.8 13.8 18.7 0.0 0.1 19.8 24.9 19.0 25.9 37.3 5.7 0.7 4.7 0.0 20.6 0.4 0.0 0.1 3.5 0.5 5.3 0.2 9.9 0.0 26.9 15.7 0.5 8.1 24.2 0.6 24.1 9.9 1.8 3.1 11.9 23.6 27.1 39.6 65.1 0.0 0.1 0.1 17.2 0.0 16.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.7 17.9 16.8 11.5 9.9 12.9 27.9 18.2 19.8 14.0 17.3 25.3 23.9 0.0 1.9 14.0 0.1 2.8 4.9 6.1 13.6 0.1 4.3 8.0 10.4 5.7 2.5 7.3 0.0 4.6 0.0 0.1 3.9 9.7 0.8 20.1 24.7 5.6 0.0 0.0 0.2 2.7 2.2 9.3 2.6 17.9 1.3 26.9 13.6 0.3 0.8 0.0 0.3 0.0 2.0 0.6 1.9 3.2 20.5 0.7 8.8 4.7 0.7 6.6 0.0 26.7 27.1 12.7 0.0 21.8 0.0 4.2 0.0 3.6 2.0 0.2 6.6 26.8 13.9 1.0 2.1 7.5 2.4 1.1 0.4 5.5 0.1 1.3 CHST7 "C6ST-2, C6ST2" ENSG00000147119 "Carbohydrate sulfotransferase 7" Q9NS84 X 46573765-46598496 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Carbohydrate metabolism" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "ovary: 35.3" "Cell type enhanced" "Detected in many" "Langerhans cells: 45.4;monocytes: 55.5;Peritubular cells: 60.2;Sertoli cells: 52.6;Skeletal myocytes: 43.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "T-reg: 18.5" "Group enriched" "Detected in many" 10 "granulocytes: 10.9;monocytes: 10.2;T-cells: 18.5" "Cell line enhanced" "Detected in many" "EFO-21: 22.8;NTERA-2: 20.5;PC-3: 17.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA003919, HPA030503" Approved Approved Nucleoplasm,Vesicles "Intracellular and membrane" NA NA 9800 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 89: Fibroblasts - ECM organization" "Cluster 38: EFO-21 - Unknown function" "Cluster 50: Fibroblasts - ECM organization" "Nucleoplasm, Vesicles" "HPA003919: AB_10601258, HPA030503: " "unprognostic (3.16e-1)" "prognostic favorable (7.20e-4)" "unprognostic (1.11e-1)" "unprognostic (2.66e-1)" "unprognostic (1.82e-2)" "unprognostic (7.85e-2)" "unprognostic (9.82e-3)" "unprognostic (3.52e-2)" "unprognostic (2.61e-1)" "unprognostic (2.81e-1)" "unprognostic (2.39e-3)" "unprognostic (6.71e-2)" "unprognostic (1.19e-1)" "unprognostic (8.85e-3)" "unprognostic (8.28e-2)" "unprognostic (1.50e-1)" "unprognostic (4.39e-2)" 13.2 3.4 5.4 1.7 7.3 2.5 7.5 6.4 7.0 11.2 3.7 3.7 0.8 5.8 0.4 2.5 4.9 1.9 17.4 5.4 7.1 4.0 7.5 3.6 1.8 6.1 7.3 35.3 2.0 1.2 4.2 2.0 6.0 4.1 0.8 0.9 3.5 1.4 4.4 7.3 4.0 1.4 4.7 10.2 3.4 2.1 8.0 1.4 5.8 3.9 0.7 4.5 7.7 4.0 5.5 4.7 3.9 3.5 10.8 7.5 0.2 7.6 5.4 2.0 2.6 1.2 2.1 0.0 22.8 3.1 1.3 4.1 3.8 1.3 1.7 3.2 8.1 1.1 0.3 4.1 16.6 1.9 0.1 2.5 1.1 3.8 3.1 3.4 6.2 2.5 0.0 4.7 1.5 2.6 0.7 2.4 20.5 0.4 17.0 3.6 3.2 10.3 5.5 0.2 8.8 3.4 1.1 0.2 0.9 9.6 1.3 0.4 1.4 6.1 0.6 3.3 3.5 11.0 2.4 1.7 6.8 0.1 0.4 2.4 2.2 0.7 1.5 7.1 1.4 1.2 5.8 2.8 1.2 0.6 1.2 1.1 10.9 0.6 10.2 0.8 18.5 1.9 5.4 7.3 6.4 7.0 5.4 7.1 6.1 7.3 6.0 4.7 8.0 4.0 33.8 0.0 3.1 22.9 2.5 12.4 2.0 4.8 1.2 0.8 2.2 3.7 7.4 10.0 2.6 1.8 0.0 5.3 11.5 1.7 1.9 2.8 0.0 3.6 20.8 16.3 0.0 0.0 0.9 2.5 4.3 23.6 0.0 1.6 0.0 19.7 15.7 4.5 11.5 3.3 4.1 2.9 0.0 14.2 45.4 0.3 19.0 14.1 14.2 4.7 55.5 5.2 4.1 13.0 1.0 1.8 1.5 60.2 4.7 6.7 0.7 2.1 1.9 0.8 52.6 43.1 11.2 0.5 1.3 1.3 13.2 1.4 9.9 11.4 0.9 3.3 CHSY1 "CSS1, KIAA0990" ENSG00000131873 "Chondroitin sulfate synthase 1" Q86X52 15 101175727-101252048 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted secreted proteins" Transferase "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "Karpas-707: 216.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "Secreted to blood" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 82: Adipose tissue - ECM organization" "Cluster 2: Karpas-707 - Immune response" "Cluster 41: Macrophages - Immune response" "unprognostic (7.28e-2)" "unprognostic (6.39e-2)" "unprognostic (9.24e-2)" "unprognostic (1.55e-1)" "unprognostic (7.60e-2)" "unprognostic (9.51e-3)" "unprognostic (1.46e-1)" "unprognostic (3.02e-3)" "unprognostic (1.77e-1)" "unprognostic (1.32e-2)" "unprognostic (5.97e-2)" "unprognostic (1.73e-1)" "prognostic unfavorable (6.33e-5)" "unprognostic (3.44e-2)" "unprognostic (1.02e-1)" "unprognostic (8.91e-3)" "unprognostic (5.58e-3)" 27.5 18.6 10.3 18.5 9.8 23.0 21.7 9.0 11.8 19.5 14.4 7.7 6.0 17.3 9.5 10.8 14.9 22.7 20.1 9.2 10.3 13.7 10.0 23.6 11.6 14.2 13.8 19.7 7.3 7.4 8.5 46.7 11.9 14.4 8.2 7.0 10.1 11.4 6.5 15.0 7.7 20.0 11.5 13.9 10.4 8.7 12.5 10.5 10.0 7.4 10.3 34.8 14.0 9.8 9.1 11.2 36.8 18.7 18.9 25.0 24.5 21.8 19.2 25.8 26.2 9.7 7.1 22.0 12.7 36.3 16.8 24.7 24.5 27.7 28.2 24.6 12.4 43.4 12.2 11.4 23.3 66.9 42.9 23.2 22.8 22.3 20.1 29.3 30.8 9.7 16.2 216.3 19.7 7.9 9.2 46.3 42.5 17.7 7.9 20.6 36.9 32.8 18.1 17.7 6.4 34.6 23.0 11.1 40.8 29.8 12.6 81.6 26.2 41.9 24.1 20.0 46.5 38.2 94.5 12.7 32.5 62.2 32.0 0.0 1.3 2.9 1.5 0.8 1.7 0.9 0.9 1.6 0.8 1.0 0.5 1.0 4.9 0.7 0.9 0.5 1.8 0.6 10.3 9.8 9.0 11.8 9.2 10.3 14.2 13.8 11.9 11.5 12.5 9.8 55.0 0.0 15.7 27.7 11.4 57.9 20.7 10.1 20.5 10.7 41.9 29.8 9.3 5.7 9.4 16.5 6.2 6.1 14.6 1.6 1.9 5.3 1.2 10.0 33.4 45.8 3.0 12.0 34.2 2.2 28.8 40.0 5.1 13.8 25.9 51.9 60.0 5.4 16.6 38.7 36.1 3.6 10.2 17.8 37.1 2.5 55.0 41.2 26.6 59.0 10.2 9.2 10.3 21.1 24.2 5.5 2.5 47.0 9.3 19.3 1.2 2.4 8.1 7.5 46.0 47.9 53.5 3.9 7.5 10.5 62.5 13.8 15.2 23.0 3.9 10.2 CHSY3 "CHSY-2, CSS3" ENSG00000198108 "Chondroitin sulfate synthase 3" Q70JA7 5 129904465-130186634 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 6.0" "Group enriched" "Detected in some" 4 "Excitatory neurons: 509.1;Inhibitory neurons: 349.5" "Low cancer specificity" "Detected in many" "Group enriched" "Detected in many" 5 "amygdala: 2.0;basal ganglia: 2.6;cerebral cortex: 2.9;hippocampal formation: 2.5;white matter: 1.1" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 13.1;ASC TERT1: 11.5;HSkMC: 7.6;TIME: 7.4;U-138 MG: 14.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA044612 Uncertain "Intracellular and membrane" NA NA "Cluster 82: Adipose tissue - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA044612: AB_10795883" "unprognostic (3.43e-2)" "unprognostic (6.28e-3)" "unprognostic (1.76e-2)" "unprognostic (5.83e-2)" "unprognostic (5.88e-2)" "unprognostic (8.17e-2)" "unprognostic (3.37e-2)" "unprognostic (1.16e-1)" "unprognostic (1.55e-1)" "unprognostic (1.22e-1)" "unprognostic (9.58e-2)" "unprognostic (3.80e-2)" "unprognostic (1.08e-6)" "unprognostic (5.22e-3)" "unprognostic (9.93e-2)" "unprognostic (4.61e-3)" "unprognostic (1.74e-2)" 6.0 0.5 2.0 1.0 2.6 0.0 2.8 0.0 2.9 4.5 0.0 0.7 0.5 1.5 0.1 0.6 1.1 2.8 1.3 2.5 0.2 0.2 1.7 1.8 0.5 0.0 0.4 0.3 0.3 0.4 0.3 2.2 0.0 0.5 0.5 1.0 0.5 0.6 1.0 1.3 0.5 2.0 0.2 0.7 0.5 0.7 0.4 0.2 1.2 0.5 0.4 1.7 1.9 1.1 0.0 0.1 1.2 0.0 13.1 11.5 1.0 3.0 0.1 0.4 0.4 0.0 0.1 0.0 0.3 4.6 0.0 0.0 0.0 0.1 0.0 0.0 1.6 1.9 5.6 0.5 1.2 0.0 0.0 7.6 0.0 0.1 1.2 0.6 3.2 0.0 0.0 1.9 5.2 0.0 0.0 0.0 0.7 0.0 1.2 0.4 5.7 0.0 0.2 0.0 4.6 0.0 0.0 0.0 0.3 1.1 0.2 0.5 7.4 14.2 3.0 0.2 2.0 0.0 0.0 0.0 0.3 0.0 4.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 2.6 0.0 2.9 2.5 0.2 0.0 0.4 0.0 0.2 0.4 1.1 2.0 9.6 1.1 20.2 0.0 0.5 0.0 0.0 1.2 0.0 0.1 0.3 0.9 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.9 0.5 14.8 2.4 0.0 0.0 509.1 0.0 0.1 2.9 0.0 0.3 0.0 4.1 3.6 1.8 1.9 0.0 349.5 0.0 0.0 1.3 0.7 0.1 1.2 0.1 3.6 87.1 0.0 1.3 0.0 76.9 19.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.7 0.1 6.6 0.9 6.3 1.6 0.7 0.3 0.3 0.4 0.2 0.6 0.0 0.1 CHUK "IkBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16" ENSG00000213341 "Component of inhibitor of nuclear factor kappa B kinase complex" O15111 10 100188300-100229596 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001402, CAB004240, CAB018564" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 59: Non-specific - Transcription" Nucleoplasm Cytosol "CAB004240: AB_627784, CAB018564: AB_649197, HPA001402: AB_1079125" "unprognostic (8.61e-3)" "unprognostic (1.70e-1)" "unprognostic (3.74e-2)" "unprognostic (3.01e-1)" "unprognostic (3.02e-2)" "unprognostic (5.93e-2)" "unprognostic (4.02e-2)" "unprognostic (2.09e-1)" "unprognostic (8.58e-2)" "unprognostic (8.39e-2)" "unprognostic (6.73e-2)" "unprognostic (1.49e-1)" "prognostic favorable (1.27e-4)" "unprognostic (2.48e-2)" "unprognostic (1.95e-1)" "unprognostic (1.88e-3)" "unprognostic (2.22e-1)" 13.5 10.3 6.6 11.7 7.6 19.6 10.8 7.1 8.3 8.4 8.3 11.9 12.8 8.8 9.1 9.7 7.5 9.0 6.8 6.4 9.2 21.0 17.0 10.2 12.7 7.3 7.5 5.6 11.5 14.0 6.5 10.5 7.6 9.6 13.3 8.0 8.8 9.0 14.2 6.9 10.8 11.8 7.7 9.9 11.2 8.3 8.7 14.3 11.1 11.7 12.6 13.6 6.4 8.7 27.7 22.9 23.0 34.4 21.6 19.3 17.6 34.3 33.5 31.3 38.0 25.9 15.9 37.2 19.7 23.5 21.8 26.7 38.7 18.2 34.9 39.8 33.5 24.7 18.0 28.7 18.4 46.2 34.8 15.5 19.1 36.2 35.0 21.8 22.7 30.1 28.5 29.9 34.6 16.7 36.9 28.4 15.0 21.8 16.5 23.7 25.5 17.0 19.9 17.6 13.7 20.3 18.6 14.2 30.9 18.0 28.5 27.8 23.9 19.6 21.9 21.5 39.7 34.9 33.7 35.7 21.3 36.9 15.8 1.0 1.2 2.1 0.9 1.9 1.5 1.6 1.1 1.6 1.4 1.0 1.3 1.5 2.8 1.8 1.3 0.8 1.2 0.5 6.6 7.6 7.1 8.3 6.4 9.2 7.3 7.5 7.6 7.7 8.7 8.7 11.4 12.8 11.5 17.9 10.8 19.8 7.1 5.1 8.0 6.3 7.3 4.8 9.2 7.2 5.9 5.5 2.1 6.5 14.1 12.2 11.7 7.1 7.6 8.9 8.6 8.4 6.0 12.0 22.7 11.8 7.8 6.5 7.7 12.7 8.2 6.2 7.1 14.4 10.6 13.5 21.3 8.0 8.2 16.9 12.7 8.0 6.2 11.7 7.2 19.7 15.6 4.5 9.2 20.6 27.7 10.4 6.0 6.0 18.5 9.6 9.5 20.0 6.4 5.0 19.7 7.8 12.0 16.4 12.9 13.2 19.0 13.8 11.1 10.1 6.6 10.6 CIITA "C2TA, MHC2TA, NLRA" ENSG00000179583 "Class II major histocompatibility complex transactivator" P33076 16 10866222-10943021 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Transcription, Transcription regulation" "Activator, Acyltransferase, Kinase, Transferase" "Cancer-related genes, Disease variant, SCID" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 57.3" "Cell type enhanced" "Detected in many" "B-cells: 48.8;Langerhans cells: 51.8;Macrophages: 43.8;Microglial cells: 42.2;monocytes: 51.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 6 "classical monocyte: 29.1;eosinophil: 17.5;intermediate monocyte: 23.5;memory B-cell: 47.3;myeloid DC: 46.2;naive B-cell: 63.3;non-classical monocyte: 29.0;plasmacytoid DC: 48.3" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HDLM-2: 51.1;REH: 89.5;U-266/70: 18.0;U-698: 25.8" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB016084, HPA054757" Enhanced Supported Nucleoplasm NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 16: Immune cells - Immune response" "Cluster 14: REH - Unknown function" "Cluster 41: Macrophages - Immune response" Nucleoplasm "CAB016084: AB_627261, HPA054757: " "unprognostic (1.45e-3)" "unprognostic (1.38e-2)" "unprognostic (8.22e-3)" "unprognostic (1.12e-2)" "unprognostic (5.66e-2)" "unprognostic (2.88e-3)" "unprognostic (2.92e-2)" "unprognostic (1.55e-2)" "unprognostic (1.15e-2)" "unprognostic (1.85e-1)" "unprognostic (1.23e-1)" "unprognostic (3.72e-1)" "unprognostic (1.64e-2)" "unprognostic (2.72e-2)" "unprognostic (6.33e-3)" "unprognostic (2.74e-1)" "unprognostic (1.05e-2)" 9.4 6.5 6.4 39.2 5.9 9.2 7.8 7.3 7.9 10.7 8.9 6.7 20.5 7.3 2.6 5.5 7.4 15.0 5.4 5.4 11.5 7.2 4.7 24.1 57.3 15.0 8.3 3.6 3.9 2.6 3.0 2.6 11.9 4.8 8.2 1.4 12.1 6.9 5.0 8.7 24.8 7.3 11.5 51.2 12.9 2.1 13.0 15.9 5.2 2.4 57.0 9.0 4.1 16.4 0.4 0.4 0.7 0.6 0.1 0.0 0.5 0.2 0.0 0.3 0.4 0.6 12.0 11.2 1.6 0.0 1.7 1.8 0.0 0.0 0.2 51.1 0.6 6.3 2.6 1.3 0.0 0.9 0.9 2.1 0.0 0.2 0.0 1.8 0.0 0.7 0.8 4.1 0.2 0.7 0.6 1.0 0.3 0.4 0.3 89.5 0.6 7.9 0.1 3.6 1.8 0.3 2.1 0.6 2.1 0.6 1.0 3.8 0.5 4.3 0.7 1.2 0.5 18.0 1.4 25.8 16.0 1.1 14.7 0.7 29.1 17.5 0.8 23.5 0.4 47.3 0.3 1.4 46.2 63.3 0.2 0.4 6.8 1.8 29.0 48.3 1.2 5.4 6.4 5.9 7.3 7.9 5.4 11.5 15.0 8.3 11.9 11.5 13.0 16.4 14.5 6.4 19.5 0.3 48.8 2.3 0.3 1.3 1.2 0.8 1.7 2.0 5.3 1.5 1.5 3.7 0.0 0.2 17.9 2.0 0.0 5.5 0.8 1.5 0.4 7.3 2.4 6.9 1.4 2.0 0.3 1.2 4.6 1.4 10.8 7.7 1.4 0.7 8.7 0.0 1.8 1.9 0.0 16.1 51.8 0.0 0.6 43.8 7.2 42.2 51.8 0.2 2.1 0.0 0.3 1.1 0.1 0.0 1.1 0.4 12.3 4.8 5.6 1.6 0.0 1.0 1.2 0.0 0.0 1.0 2.8 0.1 3.0 0.4 1.5 0.5 CILK1 "ICK, KIAA0936, LCK2, MGC46090, MRK" ENSG00000112144 "Ciliogenesis associated kinase 1" Q9UPZ9 6 53001279-53061824 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cilium biogenesis/degradation" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 11.0;Cytotrophoblasts: 20.6;Extravillous trophoblasts: 33.9;Syncytiotrophoblasts: 58.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000791, HPA001113" Approved Supported "Nucleoli fibrillar center" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 24: Non-specific - Transcription regulation" "Nucleoli fibrillar center" "HPA000791: AB_2732392, HPA001113: AB_1851385" "unprognostic (1.75e-2)" "unprognostic (1.02e-1)" "unprognostic (5.47e-2)" "unprognostic (2.95e-1)" "unprognostic (2.32e-1)" "unprognostic (1.00e-2)" "unprognostic (1.44e-1)" "unprognostic (1.82e-2)" "unprognostic (1.17e-3)" "unprognostic (5.11e-2)" "unprognostic (1.18e-1)" "unprognostic (8.28e-2)" "unprognostic (8.12e-3)" "unprognostic (1.21e-1)" "unprognostic (1.39e-1)" "unprognostic (1.07e-1)" "unprognostic (2.26e-1)" 7.9 17.9 10.2 4.9 11.0 2.7 10.7 8.4 9.7 8.9 5.1 8.7 9.8 8.0 5.5 8.6 7.4 6.9 8.5 6.8 7.8 4.5 7.5 6.3 5.2 9.4 11.6 9.5 5.0 7.3 1.7 12.1 8.8 9.9 10.7 17.4 17.9 7.3 4.0 8.7 10.4 7.4 8.8 5.6 12.9 4.5 14.9 10.1 6.3 5.0 6.2 6.5 5.8 12.8 7.8 2.9 14.6 10.0 8.9 14.0 17.0 6.9 12.4 10.8 12.3 4.1 2.4 5.7 4.0 21.0 3.5 5.0 17.6 7.1 14.2 19.9 7.0 4.2 3.3 22.3 4.5 5.2 5.4 12.5 7.6 4.6 5.3 7.7 10.2 12.1 8.1 22.6 24.9 6.7 5.6 6.4 5.6 27.0 6.3 8.8 6.5 7.5 4.5 5.6 23.6 10.6 6.7 16.3 9.6 14.2 9.5 10.9 8.5 17.2 8.0 6.5 17.1 6.3 4.8 2.2 3.5 5.0 8.5 2.8 1.0 2.2 1.7 0.8 1.5 1.2 1.2 1.4 1.0 1.5 1.4 1.2 0.5 1.1 0.9 1.4 1.7 0.8 10.2 11.0 8.4 9.7 6.8 7.8 9.4 11.6 8.8 8.8 14.9 12.8 6.3 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.0 0.0 0.0 0.0 0.0 20.6 5.7 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 33.9 5.3 0.0 0.0 0.0 0.0 0.0 0.0 6.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.2 0.0 0.0 0.0 0.0 58.1 0.8 0.0 0.0 0.0 CIT "CITK, CRIK, KIAA0949, STK21" ENSG00000122966 "Citron rho-interacting serine/threonine kinase" O14578 12 119685791-119877320 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Differentiation, Mitosis, Neurogenesis" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Primary microcephaly" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 26.2" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 87.6;Early spermatids: 72.8;Excitatory neurons: 147.0;Inhibitory neurons: 139.8;Oligodendrocyte precursor cells: 82.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019082, HPA048812, HPA075506" Uncertain Approved Cytosol NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Cytosol "HPA019082: AB_1846803, HPA048812: AB_2680528, HPA075506: AB_2686752" "unprognostic (5.64e-2)" "unprognostic (5.00e-2)" "unprognostic (8.16e-2)" "unprognostic (5.12e-3)" "unprognostic (1.25e-1)" "unprognostic (3.55e-2)" "unprognostic (3.61e-6)" "unprognostic (6.02e-2)" "unprognostic (7.78e-2)" "unprognostic (4.42e-1)" "unprognostic (1.37e-3)" "unprognostic (4.88e-2)" "unprognostic (2.55e-3)" "unprognostic (8.56e-2)" "unprognostic (1.50e-1)" "unprognostic (1.70e-1)" "unprognostic (3.30e-1)" 0.7 2.2 13.5 1.6 26.2 6.3 0.6 0.0 19.9 0.9 0.0 2.1 1.2 0.4 0.0 2.5 0.5 0.5 0.6 15.2 5.4 2.5 0.3 1.8 1.5 0.2 5.0 0.3 0.2 0.1 1.6 1.4 0.4 0.5 2.5 3.4 0.8 0.2 0.5 1.6 1.9 0.9 0.9 3.0 2.2 4.8 14.2 6.8 0.6 0.3 2.3 0.5 1.3 6.6 26.2 20.6 21.7 15.3 2.4 6.3 10.4 22.0 19.1 21.8 16.6 14.5 10.3 18.4 10.0 14.2 9.3 14.6 14.4 9.5 32.1 13.6 7.5 25.7 13.2 7.1 0.3 12.7 20.6 0.9 1.2 23.7 14.8 7.3 15.5 19.9 14.5 15.2 19.5 12.2 22.4 14.0 10.4 8.7 12.5 19.3 39.8 6.3 5.0 11.1 15.5 8.4 31.9 6.5 16.0 9.6 23.2 10.6 11.5 21.9 21.4 17.2 22.7 9.9 12.6 14.2 16.8 12.5 35.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 13.5 26.2 0.0 19.9 15.2 5.4 0.2 5.0 0.4 0.9 14.2 6.6 4.1 6.4 13.0 8.5 1.2 3.3 0.7 1.0 0.6 8.2 1.8 1.5 1.8 0.0 5.6 9.2 87.6 3.5 0.6 1.1 0.0 0.2 72.8 2.4 2.1 2.7 1.8 12.8 147.0 0.8 4.8 2.2 3.1 3.6 1.3 10.5 1.1 0.7 3.6 0.0 139.8 4.4 6.1 3.7 0.8 44.1 1.2 2.0 3.6 7.5 0.0 15.4 1.0 82.4 18.7 0.2 0.1 1.2 4.1 0.4 0.8 7.5 1.7 15.2 0.0 0.6 3.3 33.2 4.2 7.7 1.3 1.0 2.2 4.3 4.4 1.0 CKB CKBB ENSG00000166165 "Creatine kinase B" P12277 14 103519667-103522833 "Cancer-related genes, Candidate cardiovascular disease genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 694.7;intestine: 653.4" "Cell type enhanced" "Detected in many" "Bipolar cells: 2767.4;Distal enterocytes: 4691.8;Distal tubular cells: 2281.3;Horizontal cells: 5042.4;Muller glia cells: 3639.8;Rod photoreceptor cells: 3789.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 10 "non-classical monocyte: 290.8" "Lineage enriched" "Detected in many" 18 "monocytes: 290.8" "Cell line enhanced" "Detected in many" "CACO-2: 455.8;HEK 293: 1399.8;SCLC-21H: 792.2;SH-SY5Y: 352.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001254, CAB047313" Enhanced Supported Cytosol No No 38000000 "Cluster 51: Monocytes - Innate immune response" "Cluster 57: Non-specific - Angiogenesis" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "CAB047313: , HPA001254: AB_1078528" "unprognostic (9.97e-2)" "unprognostic (1.33e-3)" "unprognostic (4.25e-3)" "unprognostic (1.10e-1)" "unprognostic (7.63e-2)" "unprognostic (3.62e-2)" "unprognostic (1.64e-1)" "unprognostic (1.30e-1)" "unprognostic (4.24e-1)" "unprognostic (4.60e-2)" "unprognostic (2.68e-3)" "unprognostic (9.89e-3)" "prognostic favorable (4.02e-8)" "unprognostic (2.62e-1)" "unprognostic (1.10e-1)" "unprognostic (1.67e-2)" "unprognostic (2.13e-1)" 90.7 60.0 471.6 25.8 627.0 3.2 47.2 641.1 694.7 105.2 192.7 653.4 36.0 222.6 16.0 54.5 197.9 17.9 269.8 428.7 482.3 161.0 9.0 60.3 4.0 427.5 440.4 58.8 27.7 108.2 74.0 4.7 345.1 301.8 151.9 471.3 37.9 208.3 80.0 76.5 120.8 113.8 434.5 6.8 479.9 97.6 596.2 2.8 87.9 47.1 5.1 298.4 101.6 383.6 2.4 54.5 321.1 14.7 4.4 2.3 6.3 37.5 0.3 2.4 1.4 455.8 7.3 0.4 36.9 29.1 9.9 70.2 109.9 1.5 0.2 9.6 1399.8 111.0 242.1 165.4 16.6 0.7 87.9 14.7 0.6 3.9 0.8 3.3 0.0 5.1 198.7 3.7 4.8 20.0 2.3 3.9 109.1 48.3 213.6 13.9 6.8 275.9 65.9 2.5 792.2 352.2 65.3 10.6 25.2 21.6 21.1 40.9 2.2 1.5 56.3 4.7 147.3 21.1 2.7 7.2 6.4 2.1 14.1 2.4 0.5 14.6 0.3 28.5 0.4 0.0 0.2 0.1 16.4 0.2 0.1 0.5 1.0 0.2 290.8 0.0 0.7 6.0 471.6 627.0 641.1 694.7 428.7 482.3 427.5 440.4 345.1 434.5 596.2 383.6 14.8 195.5 103.5 515.8 13.5 153.7 296.2 257.6 56.3 2767.4 41.5 48.9 553.5 145.8 117.9 114.0 1909.9 4.4 3.4 4691.8 2281.3 127.6 445.8 773.2 205.7 60.8 467.1 9.9 178.0 42.5 11.7 96.6 359.4 408.5 28.6 476.1 74.6 9.2 8.2 5042.4 147.0 726.0 187.2 2.8 44.9 147.4 304.1 39.8 181.5 88.1 74.2 3639.8 0.0 93.5 161.2 131.4 1996.9 1089.3 6.6 279.8 9.5 118.0 456.1 3789.9 59.2 15.4 222.6 127.3 97.4 22.1 175.2 41.6 19.1 12.2 755.6 220.1 CKM CKMM ENSG00000104879 "Creatine kinase, M-type" P06732 19 45306413-45322875 "Candidate cardiovascular disease genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 11 "skeletal muscle: 73556.4;tongue: 26058.9" "Cell type enriched" "Detected in some" 8 "Cardiomyocytes: 5353.0" "Cancer enriched" "Detected in many" 4 "head and neck cancer: 64.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 4 "SCLC-21H: 68.8" "Region enriched" "Detected in single" 15 "olfactory bulb: 1.5" "Low region specificity" "Detected in many" HPA047859 Enhanced NA NA 170000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 54: Cardiomyocytes - Muscle contraction" "HPA047859: AB_2680186" "unprognostic (3.51e-1)" "unprognostic (7.63e-2)" "unprognostic (2.61e-2)" "unprognostic (4.14e-1)" "unprognostic (7.68e-3)" "unprognostic (4.04e-3)" "unprognostic (1.85e-2)" "unprognostic (4.23e-2)" "unprognostic (5.19e-2)" "unprognostic (1.81e-1)" "unprognostic (5.00e-1)" "unprognostic (9.46e-3)" "unprognostic (9.67e-8)" "unprognostic (3.23e-1)" "unprognostic (1.73e-1)" "unprognostic (2.33e-1)" "unprognostic (1.95e-1)" 8.5 2.7 0.1 0.0 0.3 0.7 12.4 0.2 0.3 0.9 0.0 6.6 0.1 1.8 0.0 512.5 0.4 0.2 4618.8 0.0 0.0 2.1 5.2 8.7 0.4 0.1 0.0 2.8 5.3 0.0 2.1 0.3 0.2 134.8 0.1 0.2 340.9 2.1 73556.4 23.4 4.3 2.4 0.0 2.5 23.5 9.9 0.0 2.5 8.5 26058.9 0.4 1.5 3.9 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 2.4 0.0 5.8 0.0 0.3 16.3 12.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 2.0 0.0 0.0 0.0 6.3 0.2 0.2 0.0 0.0 68.8 0.0 0.0 0.1 0.1 0.0 0.1 16.3 0.1 0.0 0.1 0.1 0.0 0.4 0.2 0.0 0.1 0.0 0.0 0.0 0.7 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.3 0.2 0.3 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 5353.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 11.7 0.1 15.3 0.8 0.9 51.2 0.0 0.0 0.4 0.0 0.7 141.8 0.0 0.1 1.3 0.4 0.4 0.0 6.6 0.0 0.5 0.0 0.0 0.9 0.3 53.2 1.5 3.2 0.0 0.0 0.9 0.0 0.0 0.5 0.4 0.0 0.0 0.7 0.0 0.0 0.0 0.1 0.8 0.0 0.0 639.9 47.3 16.5 1.6 0.0 0.1 0.3 2.6 3.6 0.0 0.1 CKMT1A CKMT1 ENSG00000223572 "Creatine kinase, mitochondrial 1A" P12532 15 43692886-43699222 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 83.9;intestine: 75.0" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 73.0;Distal enterocytes: 110.5;Intestinal goblet cells: 53.4;Paneth cells: 57.4;Proximal enterocytes: 94.5;Syncytiotrophoblasts: 94.0;Undifferentiated cells: 92.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HaCaT: 127.5;hTCEpi: 56.8;OE19: 144.3;SK-BR-3: 107.8;T-47d: 100.3" HPA043491 Uncertain "Intracellular and membrane" NA NA 2000000 "Cluster 37: Intestine - Unknown function" "Cluster 21: OE19 - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA043491: AB_2678510" "unprognostic (2.04e-2)" "unprognostic (2.53e-2)" "unprognostic (1.17e-1)" "unprognostic (4.02e-3)" "unprognostic (3.80e-1)" "unprognostic (7.44e-2)" "unprognostic (2.21e-1)" "unprognostic (3.10e-1)" "unprognostic (1.75e-1)" "unprognostic (1.31e-1)" "unprognostic (1.72e-1)" "unprognostic (2.51e-2)" "unprognostic (3.78e-9)" "unprognostic (3.52e-2)" "unprognostic (1.03e-1)" "unprognostic (7.37e-2)" "unprognostic (1.73e-3)" 1.8 3.8 20.8 7.1 22.1 0.0 7.7 29.3 46.4 10.1 12.6 75.0 70.6 0.5 0.4 83.9 2.1 9.4 0.8 21.9 27.3 6.0 0.2 0.9 0.1 24.9 15.8 0.1 3.5 12.3 8.5 9.5 26.9 4.4 69.4 31.8 31.4 1.1 0.1 38.0 63.1 3.4 10.7 0.1 23.3 0.3 23.0 0.2 2.8 0.0 14.7 8.3 26.1 25.7 0.3 2.9 0.7 0.1 1.3 0.0 31.9 0.0 0.0 0.0 0.0 6.8 22.1 0.1 1.4 0.0 2.4 127.5 22.4 39.0 0.0 0.0 17.1 0.0 2.1 0.7 0.0 0.0 6.1 0.2 56.8 0.0 10.3 0.0 0.0 5.0 5.7 0.1 0.0 34.8 0.0 0.2 10.1 144.3 8.2 0.1 0.0 6.7 6.7 4.7 47.1 20.0 0.0 107.8 8.6 2.9 100.3 0.8 0.0 0.0 2.3 0.3 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 20.8 22.1 29.3 46.4 21.9 27.3 24.9 15.8 26.9 10.7 23.0 25.7 0.1 0.0 0.0 2.3 0.3 17.7 10.5 30.3 1.8 6.7 4.2 5.2 0.5 10.0 14.9 1.8 20.9 73.0 0.1 110.5 27.4 4.2 0.0 0.7 0.0 0.3 18.0 0.0 10.6 20.2 23.5 0.4 26.0 0.8 8.9 1.5 0.0 0.0 4.5 6.7 9.0 53.4 12.2 0.0 0.7 0.2 0.0 0.0 5.4 1.0 0.0 4.8 0.0 1.5 1.6 12.9 57.4 0.0 0.0 2.7 94.5 1.0 4.1 11.6 0.0 0.0 0.9 0.0 0.1 16.1 18.5 94.0 0.4 0.0 92.7 20.1 CKMT1B "CKMT, CKMT1, UMTCK" ENSG00000237289 "Creatine kinase, mitochondrial 1B" P12532 15 43593054-43604901 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 58.5;esophagus: 74.3;intestine: 80.7" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 122.4;Distal enterocytes: 146.4;Intestinal goblet cells: 78.3;Paneth cells: 69.9;Proximal enterocytes: 124.6;Syncytiotrophoblasts: 137.9;Undifferentiated cells: 123.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HaCaT: 139.8;hTCEpi: 69.2;OE19: 156.0;SK-BR-3: 183.1;T-47d: 100.7" HPA043491 Uncertain "Intracellular and membrane" NA NA 2000000 "Cluster 45: Intestine - Brush border" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA043491: AB_2678510" "unprognostic (3.47e-2)" "unprognostic (9.73e-3)" "unprognostic (3.10e-1)" "prognostic unfavorable (2.55e-5)" "unprognostic (1.29e-1)" "unprognostic (1.96e-1)" "unprognostic (5.19e-2)" "unprognostic (2.84e-1)" "unprognostic (3.64e-1)" "unprognostic (5.75e-2)" "unprognostic (2.39e-1)" "unprognostic (1.15e-2)" "unprognostic (2.26e-8)" "unprognostic (1.71e-2)" "unprognostic (1.69e-1)" "unprognostic (4.43e-2)" "unprognostic (4.36e-2)" 1.9 1.9 24.6 6.3 25.1 0.0 6.0 38.0 58.5 8.0 14.3 80.7 63.4 0.3 0.4 74.3 1.9 8.9 0.7 26.5 31.5 5.3 0.1 0.7 0.1 32.4 25.2 0.1 3.1 11.9 9.5 12.8 34.6 3.1 66.0 23.4 28.5 0.8 0.1 26.7 49.4 4.0 13.8 0.0 29.6 0.2 28.6 0.1 6.2 0.0 13.3 8.4 22.0 22.2 0.3 0.9 0.8 0.0 0.2 0.0 35.3 0.0 0.0 0.1 0.1 7.8 23.8 0.0 1.0 0.0 7.2 139.8 28.4 55.8 0.1 0.8 16.0 0.0 3.0 3.8 0.0 0.1 8.6 0.0 69.2 0.0 6.9 0.0 0.0 5.9 9.1 0.0 0.0 38.2 0.1 0.2 12.0 156.0 14.9 0.0 0.0 0.8 3.0 3.7 55.4 19.5 0.9 183.1 10.9 2.3 100.7 0.0 0.0 0.1 1.8 0.2 2.3 0.1 0.2 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 24.6 25.1 38.0 58.5 26.5 31.5 32.4 25.2 34.6 13.8 28.6 22.2 0.1 0.0 0.5 2.6 0.1 25.1 10.4 40.5 3.4 7.5 3.8 4.1 0.4 5.7 12.7 5.5 18.8 122.4 0.4 146.4 21.5 4.0 0.0 0.9 0.0 0.5 21.0 0.0 37.6 28.0 26.1 0.5 33.1 0.5 0.0 1.1 0.0 0.0 9.4 6.7 36.5 78.3 10.2 0.0 0.7 0.0 0.0 0.1 3.6 2.8 0.0 2.2 0.0 5.0 2.4 18.6 69.9 0.0 0.1 2.0 124.6 0.9 6.0 12.2 0.0 0.0 0.7 0.0 0.0 17.5 24.7 137.9 0.6 0.0 123.7 19.9 CKMT2 SMTCK ENSG00000131730 "Creatine kinase, mitochondrial 2" P17540 5 81233320-81266398 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 49 "heart muscle: 1240.1;skeletal muscle: 1430.8;tongue: 2324.4" "Cell type enriched" "Detected in many" 20 "Cardiomyocytes: 814.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 7 "NK-cell: 1.1" "Lineage enriched" "Detected in single" 7 "NK-cells: 1.1" "Cell line enhanced" "Detected in many" "BEWO: 3.5;T-47d: 6.3" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA051880 Enhanced NA NA 3000000 "Cluster 48: NK-cells - Unknown function" "Cluster 38: Heart - Muscle contraction" "Cluster 6: T47d - Mammary gland" "Cluster 54: Cardiomyocytes - Muscle contraction" "HPA051880: AB_2681650" "unprognostic (3.64e-3)" "unprognostic (1.15e-1)" "unprognostic (2.82e-3)" "unprognostic (1.88e-2)" "unprognostic (1.21e-2)" "unprognostic (2.41e-2)" "unprognostic (1.73e-2)" "unprognostic (3.57e-2)" "unprognostic (2.12e-1)" "unprognostic (1.03e-1)" "unprognostic (2.82e-1)" "unprognostic (1.84e-1)" "unprognostic (1.60e-2)" "unprognostic (5.34e-2)" "unprognostic (2.28e-1)" "unprognostic (1.76e-1)" "unprognostic (2.75e-3)" 18.2 33.6 12.3 0.8 15.0 0.1 4.6 17.3 12.3 8.1 24.4 3.2 1.1 6.4 11.4 20.2 6.9 8.1 1240.1 11.2 15.0 14.7 1.0 2.5 1.3 16.3 16.8 10.2 7.7 15.7 4.5 0.7 14.9 13.1 0.7 1.6 26.3 13.1 1430.8 4.7 2.8 8.8 12.0 1.8 17.9 3.6 16.1 0.8 4.9 2324.4 0.4 4.1 4.1 17.7 0.3 0.7 0.8 1.3 1.9 0.4 3.5 0.1 0.0 0.0 0.0 2.4 0.2 1.4 0.4 0.0 1.0 0.0 0.0 0.0 0.0 1.5 2.4 0.1 1.0 3.2 2.6 0.6 0.2 0.8 0.0 0.0 0.0 0.3 0.0 2.1 0.3 0.5 0.0 2.2 1.2 0.2 1.0 0.0 0.7 0.6 1.0 0.1 0.0 0.0 1.4 1.0 1.2 0.3 1.4 1.5 6.3 0.3 0.7 0.4 1.2 0.7 0.2 0.2 0.1 1.3 0.4 0.9 0.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 1.1 0.0 0.0 0.0 0.0 12.3 15.0 17.3 12.3 11.2 15.0 16.3 16.8 14.9 12.0 16.1 17.7 1.8 0.0 0.5 40.1 0.0 0.1 0.4 0.0 1.2 0.9 0.9 0.8 814.1 7.2 0.6 12.9 0.0 0.1 0.0 0.1 37.2 1.7 25.1 13.6 3.5 9.8 0.0 0.0 11.4 0.6 0.4 16.2 6.6 27.8 0.0 0.8 0.0 0.0 0.1 0.0 18.1 0.3 0.0 0.0 0.0 2.2 7.2 0.3 3.6 23.4 0.0 1.4 0.0 4.5 9.1 0.4 0.0 15.1 0.0 0.3 0.3 0.6 0.7 1.0 0.0 11.6 15.0 1.0 0.4 0.1 0.1 0.3 0.8 23.7 2.5 0.2 CLK1 ENSG00000013441 "CDC like kinase 1" P49759 2 200853009-200864744 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033141, HPA062405" Approved Supported "Nucleoplasm,Nuclear membrane" NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 2: Karpas-707 - Immune response" "Cluster 22: Epithelial cell types - Mixed function" "Nucleoplasm, Nuclear membrane" "CAB033141: AB_1121713, HPA062405: AB_2684753" "unprognostic (9.79e-2)" "unprognostic (2.05e-1)" "unprognostic (2.15e-2)" "unprognostic (1.63e-1)" "unprognostic (9.19e-2)" "unprognostic (4.50e-3)" "unprognostic (1.52e-1)" "unprognostic (2.77e-3)" "unprognostic (1.78e-2)" "unprognostic (2.09e-2)" "unprognostic (1.09e-2)" "unprognostic (5.63e-3)" "unprognostic (2.03e-3)" "unprognostic (9.66e-2)" "unprognostic (2.30e-1)" "unprognostic (1.18e-1)" "prognostic favorable (2.28e-4)" 89.6 82.7 132.9 25.4 137.1 178.0 72.2 140.9 201.6 118.5 136.2 78.3 20.8 65.8 51.1 58.5 85.5 56.5 83.9 133.9 137.7 83.3 84.4 90.3 55.9 138.1 133.4 140.3 63.6 29.0 82.3 64.8 138.6 109.7 24.2 133.8 68.9 49.6 80.4 62.5 51.6 30.9 135.2 113.0 53.2 28.1 134.1 76.0 92.5 71.4 42.0 77.8 112.8 176.0 17.9 13.5 22.6 6.5 24.4 26.1 17.1 19.2 26.8 19.3 25.5 24.6 11.8 5.5 13.1 11.4 11.1 19.7 27.9 8.8 38.2 27.3 24.0 18.1 35.9 30.7 14.7 19.5 31.1 12.3 39.9 23.4 41.8 20.6 11.4 9.5 23.3 77.1 27.0 12.3 23.0 58.4 13.9 11.4 29.8 24.8 25.7 31.8 13.0 11.2 22.0 17.8 16.4 6.1 32.7 12.9 5.3 13.2 19.5 21.4 14.8 21.5 22.0 46.8 20.9 13.7 14.2 15.4 14.9 40.0 7.2 18.6 14.5 5.0 17.3 17.4 15.7 15.8 4.8 11.7 15.6 12.9 16.9 9.5 6.0 11.1 17.2 10.4 132.9 137.1 140.9 201.6 133.9 137.7 138.1 133.4 138.6 135.2 134.1 176.0 122.1 44.8 85.4 112.0 164.2 168.8 263.0 73.6 114.4 59.0 112.9 97.0 96.6 41.5 87.1 27.6 100.1 46.7 213.5 110.9 19.6 31.4 2.3 111.2 108.8 113.6 134.3 87.5 51.7 26.9 56.6 142.5 81.1 173.6 136.9 77.9 82.1 43.3 58.5 52.2 53.6 124.2 50.8 100.5 285.8 9.4 92.9 192.3 154.7 62.8 56.2 54.6 76.2 58.3 169.0 32.0 117.7 75.6 169.0 133.3 88.2 14.9 70.1 99.6 111.7 97.8 128.4 33.1 27.7 117.0 151.7 90.3 261.2 43.0 88.6 184.2 CLK2 ENSG00000176444 "CDC like kinase 2" P49760 1 155262868-155278491 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA055366, HPA059507" Approved Enhanced "Nucleoplasm,Nuclear bodies" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 29: U-266 - Adaptive immune response" "Cluster 43: Cardiomyocytes - Nuclear processes" Nucleoplasm "Nuclear bodies" "HPA055366: AB_2682795, HPA059507: AB_2684044" "unprognostic (2.00e-2)" "unprognostic (1.35e-2)" "prognostic unfavorable (3.77e-4)" "unprognostic (2.84e-2)" "unprognostic (3.16e-1)" "unprognostic (1.75e-1)" "prognostic unfavorable (2.82e-4)" "unprognostic (2.38e-1)" "unprognostic (2.36e-1)" "unprognostic (1.36e-2)" "unprognostic (7.66e-2)" "unprognostic (3.84e-2)" "prognostic unfavorable (2.95e-9)" "unprognostic (1.70e-1)" "unprognostic (1.40e-1)" "unprognostic (1.11e-1)" "prognostic favorable (5.43e-4)" 23.7 25.6 11.6 10.7 11.9 11.4 24.4 14.2 14.4 39.2 14.1 24.1 11.7 29.8 12.7 22.6 28.7 9.6 18.5 11.7 12.7 26.8 29.0 22.0 19.6 12.3 11.7 33.9 23.9 14.0 31.4 13.8 12.4 33.1 8.7 9.4 23.3 11.2 16.2 27.5 24.0 10.9 11.7 40.1 20.8 16.2 12.4 18.6 33.2 8.5 15.9 28.1 29.9 13.2 10.8 10.5 29.8 11.4 17.3 9.1 22.5 8.1 12.3 8.2 7.8 13.1 8.7 23.3 9.7 6.6 4.0 17.0 16.8 13.5 6.3 11.4 17.7 20.4 12.9 15.4 14.6 26.8 20.5 7.6 10.7 11.3 20.3 19.0 13.6 16.9 29.6 15.4 10.5 22.2 12.1 11.3 21.2 27.2 17.6 17.7 21.6 28.0 17.9 25.8 11.8 25.1 4.5 10.9 9.9 21.4 15.9 24.9 9.3 4.3 12.1 9.1 9.1 31.6 28.6 22.9 9.9 19.1 5.9 0.5 0.8 1.9 0.8 0.4 1.6 1.2 1.5 0.8 0.9 0.9 1.6 1.6 0.8 0.5 0.4 0.8 0.9 0.6 11.6 11.9 14.2 14.4 11.7 12.7 12.3 11.7 12.4 11.7 12.4 13.2 9.2 16.0 24.3 9.8 13.7 4.6 5.7 4.2 17.6 5.7 7.8 7.5 14.9 12.8 12.6 7.3 4.2 8.0 7.1 5.4 0.0 6.5 6.5 6.9 15.2 11.1 6.7 8.4 8.3 4.4 8.0 11.3 25.0 9.5 10.1 12.1 7.5 8.4 6.9 5.0 6.8 9.1 2.0 11.4 4.5 6.6 7.8 10.4 3.6 9.4 9.5 5.4 8.2 9.5 8.0 4.9 4.8 3.0 17.1 5.7 5.1 3.2 5.1 7.2 6.6 6.4 12.6 8.6 4.3 14.3 4.5 12.4 11.0 7.4 7.2 5.1 CLK3 ENSG00000179335 "CDC like kinase 3" P49761 15 74598500-74645414 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA046817 Approved Supported "Nucleoplasm,Intermediate filaments" NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 30: Epithelial cell lines - Translation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "Intermediate filaments" "HPA046817: AB_10964124" "unprognostic (4.10e-2)" "unprognostic (8.43e-2)" "prognostic unfavorable (2.05e-6)" "unprognostic (1.91e-3)" "unprognostic (7.91e-2)" "unprognostic (5.76e-2)" "unprognostic (1.46e-1)" "unprognostic (1.30e-2)" "unprognostic (1.95e-1)" "unprognostic (2.54e-1)" "unprognostic (8.14e-3)" "prognostic unfavorable (5.92e-4)" "unprognostic (1.35e-2)" "unprognostic (2.24e-1)" "unprognostic (9.73e-2)" "unprognostic (2.48e-1)" "unprognostic (2.25e-2)" 35.9 28.7 30.3 26.5 31.8 112.4 34.6 36.4 35.9 36.7 32.8 36.6 28.9 32.3 25.9 38.6 31.3 32.7 28.3 30.2 31.2 30.0 29.4 34.0 37.7 32.8 31.6 38.4 33.9 35.3 32.3 31.6 32.5 31.9 21.8 33.1 36.1 29.7 50.7 41.7 33.7 26.2 29.5 41.7 35.1 44.4 32.2 55.8 32.3 52.1 30.3 37.8 33.8 35.4 56.7 35.1 45.5 25.6 57.2 43.4 35.8 37.7 59.2 52.7 64.3 47.9 36.4 51.2 27.2 33.9 73.5 39.0 85.4 36.3 34.3 73.2 46.9 63.0 52.0 33.6 90.7 17.2 46.6 54.8 71.0 69.4 57.4 64.0 58.6 51.0 31.3 36.2 31.1 39.9 50.9 57.3 29.1 55.7 24.6 40.7 21.8 33.7 41.1 40.3 25.5 29.9 30.2 33.0 34.3 34.7 31.4 33.8 27.3 31.0 23.7 19.7 50.2 59.0 51.8 42.2 27.2 82.4 40.1 74.2 65.5 90.0 68.9 74.1 68.2 71.0 73.6 71.9 61.3 78.8 74.4 70.9 115.9 90.7 97.7 69.5 87.7 85.9 30.3 31.8 36.4 35.9 30.2 31.2 32.8 31.6 32.5 29.5 32.2 35.4 29.8 6.4 38.4 14.0 34.1 44.9 44.9 41.6 26.2 35.5 22.8 15.9 18.6 28.6 35.1 12.9 56.3 27.7 41.8 46.7 31.3 34.2 83.6 25.8 19.9 28.6 29.3 31.5 6.6 24.2 46.2 24.5 37.8 41.5 21.5 27.4 21.4 13.4 27.5 28.6 7.9 34.7 42.7 23.3 34.4 19.8 27.7 28.4 28.4 6.5 29.5 18.0 29.9 7.1 9.6 30.8 52.0 20.3 26.6 38.9 35.5 18.6 23.4 42.6 13.1 20.4 35.8 45.4 21.4 21.0 41.9 58.6 40.1 20.4 28.1 63.5 CLK4 ENSG00000113240 "CDC like kinase 4" Q9HAZ1 5 178602664-178630615 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 5 "Early spermatids: 297.5;Late spermatids: 518.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA043746 Approved Approved "Actin filaments" No No "Cluster 5: Granulocytes - Unknown function" "Cluster 54: Non-specific - Microtubule organization" "Cluster 20: HeLa - Mitochondria" "Cluster 34: Spermatids - Unknown function" "Actin filaments" "HPA043746: AB_2678650" "unprognostic (9.46e-2)" "unprognostic (2.24e-2)" "unprognostic (1.48e-1)" "unprognostic (3.44e-2)" "unprognostic (1.59e-1)" "unprognostic (7.16e-3)" "unprognostic (2.67e-1)" "unprognostic (2.04e-2)" "unprognostic (4.37e-2)" "unprognostic (5.92e-2)" "unprognostic (2.90e-3)" "unprognostic (9.62e-3)" "unprognostic (1.13e-2)" "unprognostic (1.26e-1)" "unprognostic (3.38e-1)" "unprognostic (1.20e-1)" "unprognostic (1.14e-3)" 13.8 11.9 14.0 7.8 14.9 10.4 13.6 22.9 20.1 20.1 14.0 14.4 9.4 12.8 11.9 10.1 13.7 9.8 13.0 14.1 14.5 13.4 13.7 10.8 17.6 15.0 14.0 18.3 17.6 7.9 10.3 10.8 15.2 16.7 6.6 34.4 13.0 8.3 17.8 15.1 12.6 5.5 14.0 18.6 12.5 15.2 14.2 16.6 16.6 21.1 10.0 12.5 21.0 19.3 8.1 7.2 6.8 10.0 19.9 15.9 11.2 7.6 8.8 4.5 8.4 7.7 6.6 4.6 6.0 3.2 5.2 10.4 8.9 6.0 7.5 16.8 6.8 1.8 15.2 8.8 7.4 3.8 5.7 7.2 8.8 7.6 9.6 15.1 3.2 3.1 4.1 13.4 5.5 3.3 5.2 13.8 3.4 5.4 4.5 4.8 6.0 6.7 4.2 2.3 7.4 5.0 8.4 4.7 8.4 3.8 5.1 8.0 6.9 9.5 3.4 4.9 8.4 8.4 3.5 3.5 6.8 9.0 5.0 7.7 5.9 12.7 8.9 4.1 12.6 12.8 9.5 8.4 5.9 10.2 12.2 9.5 16.1 8.4 4.3 7.4 9.6 4.9 14.0 14.9 22.9 20.1 14.1 14.5 15.0 14.0 15.2 14.0 14.2 19.3 31.9 16.0 27.8 45.7 57.8 31.9 44.5 18.4 40.9 70.8 23.5 21.6 22.9 11.5 23.7 14.7 39.6 20.1 52.1 12.2 5.9 9.4 297.5 22.8 30.1 25.4 6.0 38.7 79.6 4.7 18.4 29.2 20.4 19.8 27.9 36.1 18.9 13.0 10.1 28.6 40.5 10.7 14.2 13.9 24.7 518.3 30.7 21.4 16.0 43.1 18.3 29.6 27.8 61.9 60.6 7.2 16.5 29.3 36.5 23.9 25.0 10.1 26.8 81.3 19.7 17.1 30.9 30.3 18.4 19.7 24.6 15.9 42.0 24.1 10.2 26.9 CLOCK "bHLHe8, KAT13D, KIAA0334" ENSG00000134852 "Clock circadian regulator" O15516 4 55427903-55546909 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Transcription factors" "Biological rhythms, DNA damage, Transcription, Transcription regulation" "Activator, Acyltransferase, DNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001867, HPA027565" Supported Enhanced Nucleoplasm,Vesicles NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 23: Testis - Cell cycle regulation" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 52: Non-specific - Transcription" Nucleoplasm Vesicles "HPA001867: AB_1078537, HPA027565: AB_1846975" "unprognostic (1.30e-2)" "unprognostic (9.02e-2)" "unprognostic (4.25e-3)" "unprognostic (2.48e-1)" "unprognostic (3.94e-2)" "unprognostic (2.00e-2)" "unprognostic (1.17e-1)" "unprognostic (1.30e-1)" "unprognostic (4.52e-2)" "unprognostic (4.32e-2)" "unprognostic (3.01e-2)" "unprognostic (5.96e-2)" "unprognostic (4.07e-2)" "unprognostic (8.31e-2)" "unprognostic (1.69e-1)" "unprognostic (5.18e-2)" "unprognostic (7.16e-2)" 5.5 6.1 3.7 4.2 4.2 1.3 5.9 8.9 5.4 8.0 5.5 5.1 4.9 6.9 5.7 9.2 5.3 4.3 7.5 4.7 5.3 6.5 5.5 4.6 2.9 2.8 3.7 6.2 5.1 10.3 5.5 5.5 3.3 6.2 5.7 11.6 4.6 6.1 9.8 6.8 5.6 7.1 3.8 4.5 6.9 14.1 3.8 3.0 10.1 9.2 3.7 5.6 6.8 5.0 20.0 9.1 7.5 11.6 11.8 11.5 3.6 18.7 16.4 12.9 12.7 5.1 14.8 5.1 9.9 22.8 10.3 15.9 9.5 15.4 23.2 6.9 3.1 4.4 9.4 6.7 10.3 7.0 4.7 6.7 15.8 18.8 18.7 10.4 13.1 4.6 10.1 10.1 21.3 10.6 4.0 4.1 5.0 16.3 9.4 2.5 8.7 3.3 11.0 10.9 7.6 6.2 13.5 16.7 8.9 6.2 5.7 4.2 17.1 18.4 19.5 6.0 26.6 9.1 7.5 3.1 15.6 5.8 14.6 0.0 0.7 0.2 0.7 0.7 1.3 0.4 0.9 0.8 1.1 0.7 0.4 0.6 0.2 0.9 0.7 0.5 0.9 0.4 3.7 4.2 8.9 5.4 4.7 5.3 2.8 3.7 3.3 3.8 3.8 5.0 32.2 41.7 27.7 49.3 15.2 31.1 21.8 28.5 27.9 63.4 21.5 14.9 55.2 14.3 27.4 14.7 43.8 11.3 11.9 21.5 1.9 13.6 34.5 34.2 39.9 32.1 39.7 3.8 95.9 16.5 6.8 28.0 25.0 32.0 3.8 16.6 28.9 27.7 11.6 33.7 114.6 18.5 18.3 17.0 26.1 16.9 23.9 16.9 10.6 70.3 14.0 26.7 19.6 82.0 93.1 28.3 13.2 36.1 18.5 34.0 29.6 19.7 25.2 41.4 13.1 36.5 28.2 64.9 72.5 55.1 37.5 5.2 14.0 21.7 15.6 51.6 CLP1 "hClp1, HEAB" ENSG00000172409 "Cleavage factor polyribonucleotide kinase subunit 1" Q92989 11 57648188-57661865 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "mRNA processing, tRNA processing" "Kinase, Transferase" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 32.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA057770 Supported Supported Nucleoplasm NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 29: Early spermatids - Spermatogenesis" Nucleoplasm "HPA057770: AB_2683523" "unprognostic (1.33e-1)" "unprognostic (7.90e-2)" "unprognostic (1.11e-3)" "unprognostic (2.13e-2)" "unprognostic (4.90e-2)" "unprognostic (3.58e-1)" "unprognostic (1.93e-3)" "unprognostic (1.16e-1)" "unprognostic (3.01e-1)" "unprognostic (1.66e-2)" "unprognostic (8.82e-2)" "unprognostic (7.58e-2)" "unprognostic (8.31e-3)" "unprognostic (3.71e-2)" "unprognostic (1.75e-1)" "unprognostic (8.78e-2)" "unprognostic (3.07e-1)" 8.9 7.4 3.1 10.1 3.6 26.1 9.2 3.9 4.4 7.1 4.4 9.0 8.7 7.7 7.6 9.2 7.3 5.9 6.5 3.3 3.3 8.0 10.1 7.3 10.8 3.3 3.1 6.8 7.4 6.8 4.4 9.2 3.7 5.6 8.6 3.2 6.7 7.1 8.2 9.0 8.4 8.9 3.4 10.0 8.1 8.4 3.3 11.2 7.2 9.3 13.1 8.6 5.0 3.7 21.2 22.2 21.0 21.6 22.3 14.4 19.7 21.4 23.2 30.1 25.8 21.4 18.4 35.1 24.3 18.9 24.2 25.9 29.2 34.5 34.2 24.3 18.0 19.4 13.5 21.7 17.7 28.5 22.2 17.4 24.0 26.9 18.6 11.9 27.7 17.4 30.4 11.9 24.9 14.8 21.8 32.9 31.8 24.3 22.2 21.7 32.1 37.5 16.5 15.0 11.1 22.3 19.1 17.2 28.7 21.7 32.7 23.2 20.0 16.0 21.7 27.7 15.9 18.6 26.4 39.3 17.3 16.3 17.3 31.2 19.0 20.0 15.9 16.4 18.9 15.6 14.1 16.4 19.0 14.3 16.4 14.9 21.7 13.6 15.9 10.8 16.2 12.3 3.1 3.6 3.9 4.4 3.3 3.3 3.3 3.1 3.7 3.4 3.3 3.7 6.1 9.6 5.1 1.0 8.5 19.4 10.7 13.4 16.5 4.3 6.0 6.2 2.4 7.2 10.5 0.0 6.2 16.5 12.7 4.8 9.8 12.9 32.5 6.7 5.7 7.3 2.4 12.2 1.9 11.7 13.9 7.4 3.1 7.1 8.2 4.9 4.2 3.5 11.0 5.0 1.8 3.2 8.2 6.0 6.9 4.1 5.6 5.8 8.8 1.0 15.0 3.3 7.2 2.5 1.4 9.8 4.7 8.6 5.9 4.7 6.2 10.1 6.4 3.1 6.6 10.4 6.9 9.4 12.0 9.3 14.5 13.5 9.7 6.5 4.6 7.8 CLYBL CLB ENSG00000125246 "Citramalyl-CoA lyase" Q8N0X4 13 99606669-99897134 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Lyase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 109.7" "Cell type enhanced" "Detected in many" "Astrocytes: 84.9;Distal tubular cells: 138.9;Hepatocytes: 84.1;Proximal tubular cells: 144.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "OE19: 56.1;SCLC-21H: 53.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039959, HPA040691" Enhanced NA NA 7300 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 8: Non-specific - Mitochondria" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA039959: AB_10793857, HPA040691: AB_10794746" "unprognostic (1.25e-2)" "unprognostic (1.94e-1)" "unprognostic (2.30e-3)" "unprognostic (7.57e-3)" "unprognostic (3.69e-1)" "unprognostic (2.90e-2)" "unprognostic (1.57e-3)" "unprognostic (2.91e-1)" "unprognostic (2.10e-1)" "unprognostic (2.34e-1)" "unprognostic (2.49e-2)" "unprognostic (2.85e-1)" "prognostic favorable (6.66e-16)" "unprognostic (3.74e-2)" "unprognostic (5.41e-2)" "unprognostic (4.78e-2)" "unprognostic (7.82e-2)" 7.1 16.2 11.4 5.5 11.8 5.1 10.5 24.4 12.7 7.7 35.3 20.6 25.0 6.5 13.0 11.3 7.9 6.9 22.6 12.6 8.6 66.0 109.7 5.6 10.4 9.1 9.0 5.7 9.8 14.4 6.7 3.7 7.3 6.9 21.9 7.3 12.3 8.9 43.3 9.3 23.5 6.4 5.6 8.6 8.7 9.3 10.7 5.8 12.3 69.5 10.8 7.4 6.9 8.8 0.4 2.3 16.6 7.5 7.6 7.0 3.6 0.8 1.6 1.4 2.6 0.3 12.4 3.0 4.8 1.0 3.2 3.9 1.5 2.8 1.8 15.3 2.4 19.2 4.9 11.8 5.2 10.4 1.3 3.8 8.3 0.2 6.4 1.6 2.2 15.7 2.7 9.8 1.6 4.3 4.7 14.3 10.8 56.1 3.4 6.0 0.7 7.1 16.6 1.1 53.1 8.1 3.4 3.8 3.6 5.9 8.0 13.2 0.3 0.7 1.9 1.4 2.7 22.3 4.7 0.6 11.3 14.9 2.3 1.7 4.5 0.5 9.9 10.0 12.0 14.5 17.4 13.9 9.4 15.7 13.3 15.8 0.6 14.2 4.8 10.3 24.2 7.7 11.4 11.8 24.4 12.7 12.6 8.6 9.1 9.0 7.3 5.6 10.7 8.8 7.4 6.4 5.0 84.9 8.6 5.5 9.1 18.4 8.6 2.3 8.9 11.3 36.1 21.5 10.9 14.7 2.1 14.3 9.2 17.9 138.9 11.6 1.6 6.1 4.1 6.2 1.2 2.5 30.6 8.1 3.2 5.9 5.6 4.4 6.3 7.1 4.6 84.1 7.6 0.0 25.6 11.5 10.2 6.7 4.5 4.8 2.1 5.4 16.0 48.7 4.4 6.5 7.2 21.6 9.5 4.0 13.8 4.1 3.8 4.3 23.1 144.7 4.1 5.0 0.0 7.6 18.1 3.0 10.5 6.9 6.3 7.4 8.3 13.6 19.1 6.7 CMAS ENSG00000111726 "Cytidine monophosphate N-acetylneuraminic acid synthetase" Q8NFW8 12 22046218-22065674 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 532.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039905 Supported Uncertain Nucleoli,Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 45: Intestine - Brush border" "Cluster 36: HEL - Hemostasis" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" Cytosol Nucleoli "HPA039905: AB_10795237" "unprognostic (5.54e-2)" "unprognostic (4.10e-2)" "unprognostic (4.25e-1)" "unprognostic (5.39e-3)" "unprognostic (1.94e-2)" "unprognostic (3.99e-2)" "unprognostic (2.30e-2)" "unprognostic (4.17e-3)" "unprognostic (1.53e-2)" "unprognostic (1.01e-1)" "unprognostic (4.44e-1)" "unprognostic (7.53e-2)" "prognostic unfavorable (7.19e-4)" "unprognostic (2.27e-1)" "unprognostic (1.91e-2)" "unprognostic (3.65e-1)" "unprognostic (2.03e-1)" 19.7 57.0 46.6 23.2 51.1 47.9 32.9 40.3 57.8 29.2 35.8 77.8 66.2 23.5 69.0 71.6 21.8 24.4 42.6 51.2 57.3 28.9 72.2 18.1 24.2 43.8 57.1 25.3 42.5 79.4 30.0 34.0 57.1 36.7 71.9 24.8 32.6 26.7 44.0 29.3 63.6 27.7 41.8 20.1 29.7 69.9 49.0 19.8 23.8 41.1 26.1 24.2 40.3 44.0 63.4 50.2 59.5 29.3 47.0 57.5 88.8 43.2 46.2 45.0 47.2 114.1 72.0 56.5 41.3 37.3 83.9 50.9 35.8 60.1 60.7 75.0 45.4 169.1 38.8 57.2 43.2 45.4 85.5 38.5 56.4 58.1 86.3 61.5 61.3 58.7 108.8 28.1 80.9 83.8 52.0 105.3 147.5 69.4 69.5 36.2 63.6 53.7 56.0 67.8 23.8 42.0 34.2 59.6 51.9 120.2 82.3 62.0 45.5 51.2 42.4 46.2 81.1 19.4 26.0 74.9 83.6 34.6 54.3 22.7 27.3 32.1 20.4 29.7 26.1 19.0 26.9 27.0 31.5 18.2 24.2 24.6 2.8 36.9 27.4 20.2 33.8 25.5 46.6 51.1 40.3 57.8 51.2 57.3 43.8 57.1 57.1 41.8 49.0 44.0 21.5 12.8 17.5 12.4 19.2 29.2 76.8 117.2 14.8 38.3 31.9 21.2 72.7 41.5 102.3 23.9 4.2 175.2 17.8 158.1 76.3 56.6 12.4 17.2 19.6 36.8 41.6 153.9 38.7 83.6 141.3 41.7 21.9 20.0 22.8 28.2 34.2 63.6 66.2 35.3 29.2 118.2 93.6 29.8 22.0 19.0 25.4 32.5 44.4 8.4 45.3 33.4 26.8 16.6 25.5 79.7 156.2 27.8 16.7 112.3 133.6 87.0 82.5 20.4 19.7 30.4 42.3 112.2 97.1 52.3 44.5 532.6 24.6 63.0 90.8 190.6 CMPK1 "CMPK, UMP-CMPK" ENSG00000162368 "Cytidine/uridine monophosphate kinase 1" P30085 1 47333797-47378839 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Pyrimidine biosynthesis" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA053730, HPA058604" Approved Supported Nucleoplasm "Intracellular and membrane" NA NA 1400000 "Cluster 34: Basophils - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 44: HDLM-2 - Immune response" "Cluster 27: Mucus-secreting cells - Mucin production" Nucleoplasm "HPA053730: AB_2682244, HPA058604: AB_2683773" "unprognostic (2.16e-2)" "unprognostic (1.16e-1)" "unprognostic (9.39e-3)" "unprognostic (1.18e-1)" "unprognostic (1.09e-3)" "unprognostic (1.50e-2)" "unprognostic (1.59e-2)" "unprognostic (9.88e-2)" "unprognostic (5.80e-2)" "unprognostic (2.90e-2)" "unprognostic (1.71e-2)" "unprognostic (2.61e-1)" "unprognostic (1.28e-2)" "unprognostic (2.58e-2)" "unprognostic (1.06e-1)" "unprognostic (1.02e-3)" "unprognostic (7.36e-2)" 88.2 45.2 47.0 64.2 50.6 53.1 102.2 51.9 73.1 74.8 49.8 134.1 163.9 44.2 42.2 108.2 35.2 88.5 63.3 44.5 56.9 78.7 217.2 63.8 71.8 52.6 52.4 38.1 90.9 57.7 32.9 48.8 54.2 95.0 141.0 29.2 157.4 50.7 71.1 65.1 152.5 56.0 52.6 58.0 109.0 17.5 52.3 61.7 92.0 73.9 87.9 80.6 63.8 55.3 124.9 68.4 86.6 77.9 154.6 179.3 122.5 216.4 129.8 128.6 129.9 61.3 84.1 183.4 108.6 147.9 120.5 82.7 64.8 112.1 174.9 279.5 52.7 142.9 91.0 106.7 100.8 206.2 100.2 101.2 132.7 107.5 119.7 121.1 135.2 67.4 137.3 143.5 169.8 45.9 168.2 96.8 55.1 162.9 93.6 103.4 149.8 138.5 126.5 134.9 78.3 41.3 155.0 177.7 128.9 113.7 44.2 121.0 127.7 159.6 92.7 154.5 180.8 103.8 154.3 124.4 126.3 125.3 111.7 43.3 12.8 24.2 16.1 14.0 20.7 13.6 18.0 20.0 13.5 14.3 16.9 16.4 5.3 19.4 17.0 11.4 20.9 15.6 47.0 50.6 51.9 73.1 44.5 56.9 52.6 52.4 54.2 52.6 52.3 55.3 101.7 70.5 54.4 14.4 148.1 175.5 125.3 88.9 102.4 34.2 167.8 67.7 48.9 147.3 87.0 75.4 16.7 82.3 117.9 280.0 174.1 186.8 1.6 56.2 63.3 83.8 117.5 126.0 28.5 181.6 133.0 91.2 125.4 98.2 94.0 39.7 88.5 235.9 75.9 43.7 30.2 326.6 91.6 122.0 265.0 5.0 59.4 107.1 254.3 31.9 100.5 66.9 124.6 20.6 25.0 146.8 168.6 70.0 119.8 203.5 234.6 254.5 112.3 31.1 85.5 75.9 95.8 14.0 29.8 167.0 195.1 118.3 160.5 49.0 240.2 250.8 CMPK2 "NDK, TYKi, UMP-CMPK2" ENSG00000134326 "Cytidine/uridine monophosphate kinase 2" Q5EBM0 2 6840570-6866635 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Pyrimidine biosynthesis" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 10.6;salivary gland: 8.5" "Cell type enriched" "Detected in many" 4 "Erythroid cells: 86.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in many" "eosinophil: 4.9" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in some" "BJ hTERT+ SV40 Large T+: 12.8;BJ hTERT+ SV40 Large T+ RasG12V: 11.9;HEL: 20.3;MOLT-4: 11.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041430 Approved Supported Nucleoplasm,Mitochondria NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 36: HEL - Hemostasis" "Cluster 6: Erythroid cells - Oxygen transport" Mitochondria Nucleoplasm "HPA041430: AB_10796674" "unprognostic (2.37e-1)" "unprognostic (6.07e-2)" "unprognostic (5.71e-2)" "prognostic unfavorable (4.71e-4)" "unprognostic (1.82e-1)" "unprognostic (5.08e-2)" "unprognostic (3.80e-2)" "unprognostic (8.93e-2)" "unprognostic (6.63e-2)" "unprognostic (4.54e-3)" "unprognostic (7.39e-3)" "unprognostic (1.43e-1)" "unprognostic (1.09e-3)" "unprognostic (1.28e-1)" "unprognostic (1.77e-2)" "unprognostic (7.69e-2)" "unprognostic (4.32e-2)" 2.1 1.4 1.7 1.4 2.8 6.4 1.8 0.7 1.8 1.4 1.7 1.3 1.6 0.9 0.3 0.7 0.7 0.8 2.1 1.2 1.9 1.1 0.9 2.8 1.3 6.0 3.0 0.4 1.3 0.9 1.1 1.6 3.2 0.7 0.6 0.1 8.5 0.7 1.1 0.4 2.2 0.9 10.6 3.5 2.9 2.0 2.0 1.9 1.2 1.6 0.7 0.9 0.6 1.5 0.3 0.0 0.1 0.0 0.0 0.0 2.5 0.0 0.2 12.8 11.9 0.0 1.4 3.1 0.8 0.0 3.3 0.2 0.0 0.0 0.0 0.3 0.2 20.3 0.0 0.0 0.0 0.6 1.8 0.1 0.0 0.2 0.0 0.0 0.0 2.0 5.8 0.1 0.0 0.1 11.8 3.6 0.3 0.0 1.0 3.6 0.0 0.0 0.0 0.4 0.4 0.5 0.2 0.0 1.9 0.0 0.0 1.3 0.0 0.0 0.2 0.0 0.0 3.3 0.4 0.0 0.0 3.6 0.8 3.1 1.6 4.9 0.3 3.9 0.2 1.1 0.2 0.2 1.1 0.1 0.2 0.3 1.1 0.5 2.0 0.1 0.4 0.7 1.7 2.8 0.7 1.8 1.2 1.9 6.0 3.0 3.2 10.6 2.0 1.5 20.8 3.2 7.5 0.0 1.9 0.4 0.9 0.5 0.0 1.5 1.7 1.3 1.6 0.0 0.5 1.8 0.0 3.0 3.4 10.0 1.9 2.6 4.0 5.4 0.8 11.7 7.2 86.3 1.9 6.6 2.9 2.7 11.2 1.0 2.5 1.7 7.1 1.4 19.5 0.0 2.5 2.5 0.0 12.3 2.8 1.6 1.5 11.3 0.0 9.4 11.9 5.3 3.1 1.5 0.2 6.2 8.4 5.7 2.1 1.0 8.4 0.7 4.1 0.2 0.0 2.2 2.0 2.7 4.4 0.7 0.4 0.8 4.5 1.6 1.6 2.0 CMTR1 "FTSJD2, ISG95, KIAA0082, MTr1" ENSG00000137200 "Cap methyltransferase 1" Q8N1G2 6 37433219-37482827 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "mRNA capping, mRNA processing" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-698: 253.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029954, HPA029979, HPA029980" Enhanced Enhanced Nucleoplasm,Vesicles NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 71: Testis - DNA repair" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 52: Non-specific - Transcription" Nucleoplasm Vesicles "HPA029954: AB_10670558, HPA029979: AB_10671363, HPA029980: AB_10671094" "unprognostic (1.33e-1)" "unprognostic (2.12e-2)" "unprognostic (6.43e-2)" "prognostic unfavorable (1.73e-5)" "unprognostic (1.00e-1)" "unprognostic (3.72e-1)" "unprognostic (1.68e-2)" "unprognostic (6.43e-3)" "unprognostic (2.95e-2)" "unprognostic (9.17e-2)" "unprognostic (5.24e-3)" "unprognostic (1.50e-3)" "unprognostic (3.00e-3)" "unprognostic (3.27e-2)" "unprognostic (9.72e-2)" "unprognostic (2.54e-1)" "unprognostic (1.14e-2)" 20.1 22.1 21.0 19.2 21.2 30.9 19.5 20.3 22.9 23.6 18.6 26.8 18.1 23.1 17.4 16.9 22.4 15.1 25.1 20.7 22.0 19.4 21.8 20.4 25.3 21.5 21.0 28.0 22.1 27.5 26.0 24.9 20.3 21.9 15.2 28.5 21.7 18.4 30.1 23.2 23.2 20.4 20.2 28.8 21.9 62.9 23.5 30.9 20.3 23.4 25.6 21.6 20.0 20.2 23.5 21.9 31.0 50.7 34.2 31.1 37.4 27.5 37.7 68.1 75.9 33.3 15.3 48.6 30.5 40.7 63.8 25.7 39.7 28.4 51.7 33.8 35.2 26.8 26.8 37.2 26.3 38.9 17.6 27.1 20.9 37.6 26.7 35.7 32.2 44.3 60.6 34.5 36.3 38.5 49.8 34.6 15.6 15.7 20.7 39.0 36.7 28.1 22.0 28.2 34.2 25.6 30.8 23.4 40.2 22.1 39.8 29.7 30.0 40.7 30.3 16.3 31.1 39.3 21.8 253.0 16.0 40.1 45.6 4.2 5.4 3.5 4.9 7.1 4.1 5.5 4.3 5.2 5.1 3.8 4.7 3.9 3.3 5.6 5.5 4.2 6.1 4.6 21.0 21.2 20.3 22.9 20.7 22.0 21.5 21.0 20.3 20.2 23.5 20.2 11.3 9.6 9.2 5.9 12.0 3.6 3.9 4.0 8.6 14.2 6.3 5.5 10.4 8.6 11.5 7.3 33.3 18.0 15.4 5.3 0.0 4.5 20.2 7.7 15.4 9.6 8.4 6.5 15.1 8.5 8.0 8.8 11.7 8.9 3.8 24.9 7.9 10.1 7.5 11.8 13.9 8.4 4.1 7.5 2.3 11.3 7.8 9.5 3.6 14.0 11.5 8.8 7.2 10.6 14.2 8.5 3.3 6.8 12.4 4.3 4.7 4.0 11.2 11.9 6.6 8.5 13.5 16.8 10.6 5.8 4.7 20.8 11.5 22.0 6.9 3.6 CMTR2 "AFT, FLJ11171, FTSJD1, MTr2" ENSG00000180917 "Cap methyltransferase 2" Q8IYT2 16 71281389-71289715 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "mRNA capping, mRNA processing" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 95.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041700, HPA048265" Uncertain Approved "Nuclear speckles,Cell Junctions" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 3: HMC-1 - Innate immune response" "Cluster 52: Non-specific - Transcription" "Cell Junctions" "Nuclear speckles" "HPA041700: AB_2677623, HPA048265: AB_2680334" "unprognostic (1.27e-1)" "unprognostic (2.49e-2)" "unprognostic (2.94e-3)" "unprognostic (1.43e-1)" "unprognostic (6.30e-2)" "unprognostic (3.82e-2)" "unprognostic (1.93e-3)" "unprognostic (2.86e-2)" "unprognostic (7.93e-2)" "unprognostic (3.41e-1)" "unprognostic (1.85e-2)" "unprognostic (7.39e-2)" "prognostic favorable (4.97e-5)" "unprognostic (9.55e-2)" "unprognostic (5.99e-2)" "unprognostic (1.54e-1)" "unprognostic (5.34e-2)" 6.7 8.8 4.0 10.3 4.6 7.2 15.9 4.6 4.2 7.6 8.0 10.1 14.9 8.5 12.2 14.3 9.0 9.4 7.0 3.2 4.7 12.5 14.3 11.4 14.4 5.1 4.4 11.2 8.1 10.7 7.8 10.6 4.8 10.8 10.4 7.3 13.3 8.0 5.7 10.3 14.2 9.0 5.2 13.6 10.0 13.8 4.9 10.7 14.1 5.7 17.9 9.7 7.6 6.6 17.8 11.6 23.2 19.5 18.9 15.3 10.6 14.9 18.2 17.4 18.4 10.6 26.5 10.0 18.4 13.7 18.9 19.4 11.1 14.2 24.9 10.5 7.9 22.3 13.1 8.3 20.3 16.8 37.7 12.7 24.7 15.4 17.9 12.8 18.5 22.2 11.6 6.6 31.1 15.9 18.8 23.1 11.0 14.2 6.7 28.5 10.2 24.5 16.3 19.5 12.0 12.8 15.1 12.2 15.4 10.3 18.0 10.4 18.7 21.1 15.1 15.5 11.4 13.3 17.6 21.3 14.7 14.6 16.8 22.6 9.6 9.2 10.8 10.3 13.2 13.1 10.6 11.7 13.7 12.0 11.4 11.1 0.7 16.6 6.9 3.9 9.8 11.4 4.0 4.6 4.6 4.2 3.2 4.7 5.1 4.4 4.8 5.2 4.9 6.6 11.4 3.2 11.8 13.7 28.1 14.1 14.5 10.7 15.9 20.3 23.9 13.7 8.6 20.0 9.4 16.5 31.3 24.2 30.2 25.8 7.9 12.2 95.6 12.6 15.1 14.6 18.6 17.0 9.9 9.7 12.7 11.5 15.8 11.5 8.2 26.1 18.9 32.7 16.1 15.2 10.3 20.5 18.3 18.0 11.4 30.9 16.8 13.6 1.8 21.5 17.8 12.1 51.5 17.6 21.5 12.9 15.2 12.4 17.9 13.5 46.3 17.7 6.5 25.5 6.6 11.1 10.1 26.1 13.8 22.0 24.3 26.4 20.0 21.8 17.9 18.2 CNOT4 "CLONE243, NOT4, NOT4H" ENSG00000080802 "CCR4-NOT transcription complex subunit 4" O95628 7 135361795-135510127 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Transcription factors" "Ubl conjugation pathway" "RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005737 Approved NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 21: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" "HPA005737: AB_1078544" "unprognostic (9.11e-2)" "unprognostic (2.12e-1)" "unprognostic (1.30e-1)" "unprognostic (5.47e-2)" "unprognostic (3.61e-1)" "unprognostic (1.64e-2)" "prognostic unfavorable (1.19e-4)" "unprognostic (2.82e-2)" "unprognostic (4.18e-2)" "prognostic favorable (1.61e-4)" "unprognostic (9.08e-2)" "unprognostic (1.00e-2)" "prognostic favorable (7.67e-6)" "unprognostic (1.01e-1)" "unprognostic (6.31e-2)" "unprognostic (2.23e-1)" "unprognostic (9.33e-2)" 9.2 8.9 10.3 8.2 11.0 7.9 8.3 16.2 14.0 11.3 5.9 8.7 7.4 11.1 9.1 10.1 10.4 8.9 12.5 10.7 13.7 10.0 10.4 8.7 10.1 9.4 10.6 15.4 9.2 13.4 6.5 10.7 9.4 9.5 8.4 15.4 11.4 9.4 21.7 10.2 7.7 11.0 7.7 9.5 8.1 17.6 10.2 11.9 13.6 22.2 11.5 9.0 8.7 11.2 15.4 14.3 14.3 19.3 23.3 18.4 10.3 16.9 18.3 14.1 17.4 12.4 15.4 15.2 14.3 15.6 20.0 14.2 18.3 12.8 20.0 17.3 14.1 12.6 11.9 11.0 12.9 14.4 14.5 14.2 16.0 18.1 11.1 16.2 14.7 10.7 22.4 11.8 21.0 19.2 19.8 21.2 18.9 14.1 11.9 12.7 14.1 16.6 16.6 14.0 15.1 17.7 19.7 21.7 11.6 13.2 13.5 15.8 20.0 17.0 10.0 15.9 18.5 18.1 18.2 21.5 17.2 16.4 23.2 23.7 10.5 14.6 12.4 10.8 13.6 9.8 10.4 10.4 9.4 10.7 11.1 10.5 9.4 15.8 13.1 7.5 9.7 9.2 10.3 11.0 16.2 14.0 10.7 13.7 9.4 10.6 9.4 7.7 10.2 11.2 53.9 22.4 43.0 83.9 63.0 67.7 76.3 54.0 45.5 50.6 49.7 58.2 42.7 31.5 44.3 36.8 106.3 31.5 60.9 30.0 70.5 32.9 30.7 31.3 56.7 48.3 40.7 50.9 103.7 20.7 22.5 58.4 35.2 45.1 62.6 46.1 40.0 25.0 25.5 55.5 94.0 30.2 30.5 28.1 61.0 20.7 65.3 33.4 42.7 88.1 61.0 69.1 68.0 119.6 102.8 32.4 31.2 69.2 58.9 73.0 32.0 56.2 35.4 72.4 19.7 83.8 75.3 113.4 75.7 42.1 75.7 44.6 61.6 45.9 29.3 89.4 COASY "DPCK, NBP, PPAT" ENSG00000068120 "Coenzyme A synthase" Q13057 17 42561467-42566277 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Coenzyme A biosynthesis" "Kinase, Multifunctional enzyme, Nucleotidyltransferase, Transferase" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA022875, HPA022912, HPA023273" Approved "Intracellular and membrane" NA NA 20000 "Cluster 44: Non-specific - Transcription" "Cluster 18: Non-specific - Mitochondria" "Cluster 16: U-266 - Nucleosome" "Cluster 40: Granulosa cells - Unknown function" "HPA022875: AB_1847066, HPA022912: AB_1847067, HPA023273: AB_1847068" "unprognostic (2.83e-1)" "unprognostic (8.35e-2)" "unprognostic (1.81e-1)" "prognostic favorable (2.15e-4)" "unprognostic (1.01e-1)" "unprognostic (5.72e-2)" "prognostic unfavorable (7.54e-5)" "unprognostic (4.06e-2)" "unprognostic (3.36e-2)" "unprognostic (2.50e-2)" "unprognostic (1.50e-1)" "unprognostic (7.83e-2)" "unprognostic (1.11e-2)" "unprognostic (2.49e-2)" "unprognostic (5.55e-1)" "unprognostic (1.62e-1)" "unprognostic (2.16e-1)" 27.4 60.0 24.0 23.1 24.0 29.5 32.8 24.7 28.1 27.6 26.7 35.6 43.3 25.2 17.2 54.4 29.8 16.9 29.4 25.4 23.9 45.6 70.9 30.3 25.0 27.8 24.7 26.0 59.0 39.0 30.3 25.5 28.1 32.4 24.3 13.3 58.5 28.7 38.6 46.6 36.9 17.2 23.8 35.9 47.2 32.4 25.7 27.6 39.0 25.3 25.2 26.8 31.1 24.6 94.2 149.1 27.2 55.2 55.5 34.8 89.2 38.3 52.9 65.8 46.5 85.7 89.2 52.7 65.6 50.4 69.5 146.9 66.1 81.4 43.7 47.6 122.2 52.5 91.2 140.9 70.2 56.4 73.1 51.5 97.8 62.4 66.6 52.4 63.2 70.5 98.7 70.8 46.6 59.2 71.5 87.2 36.7 125.8 75.1 39.1 93.5 88.1 89.9 66.7 63.3 50.1 34.9 37.3 75.4 52.2 158.0 70.4 41.6 68.3 62.3 52.4 40.1 84.6 127.4 31.0 80.9 55.3 47.5 23.3 29.8 26.8 19.7 31.8 20.5 15.8 15.8 19.1 33.6 15.7 15.7 16.3 19.5 21.0 22.5 23.6 18.1 24.0 24.0 24.0 24.7 28.1 25.4 23.9 27.8 24.7 28.1 23.8 25.7 24.6 15.4 6.4 23.8 9.8 24.1 15.0 21.7 49.5 25.6 17.8 38.2 22.9 22.9 40.0 33.3 71.7 0.0 89.4 21.2 53.7 33.2 44.8 4.4 31.5 20.6 20.6 17.4 30.3 5.6 52.5 51.6 18.7 40.2 28.0 10.2 101.2 23.9 94.2 40.3 33.7 5.7 36.7 42.7 23.6 16.1 7.7 14.9 19.9 14.2 4.7 36.2 29.4 20.6 3.5 5.9 38.9 32.4 16.6 25.3 31.2 66.3 94.8 36.5 18.0 26.3 15.2 18.6 46.7 31.1 33.4 17.8 77.2 16.9 36.6 45.1 30.7 COLGALT1 "FLJ22329, GLT25D1" ENSG00000130309 "Collagen beta(1-O)galactosyltransferase 1" Q8NBJ5 19 17555649-17583162 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 76.2;Hofbauer cells: 91.0;Kupffer cells: 70.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA047821 Approved Approved Vesicles "Intracellular and membrane" No No 9700 "Cluster 7: Monocytes - Unknown function" "Cluster 19: Lung - Lung function" "Cluster 32: U-937 - Innate immune response" "Cluster 4: Macrophages - Innate immune response" Vesicles "HPA047821: AB_2680168" "unprognostic (2.46e-1)" "unprognostic (1.16e-1)" "unprognostic (3.49e-1)" "unprognostic (1.85e-1)" "unprognostic (1.17e-1)" "unprognostic (1.56e-1)" "prognostic unfavorable (1.65e-5)" "unprognostic (2.92e-3)" "unprognostic (2.92e-1)" "unprognostic (1.66e-3)" "prognostic unfavorable (1.92e-4)" "unprognostic (3.89e-2)" "prognostic unfavorable (0.00e+0)" "unprognostic (1.43e-2)" "unprognostic (1.09e-1)" "unprognostic (8.87e-2)" "prognostic unfavorable (3.83e-4)" 38.6 14.3 5.9 38.1 6.9 32.9 27.5 7.9 8.4 31.1 10.6 27.7 16.2 28.4 4.4 17.9 26.5 19.0 22.4 7.1 9.1 12.7 16.3 34.9 29.7 12.1 9.3 23.5 15.8 9.0 10.1 40.9 12.3 15.5 15.2 3.2 15.9 16.3 15.1 23.9 24.7 35.4 7.6 39.5 18.2 11.9 18.9 9.9 14.7 7.5 15.8 28.1 22.8 12.6 103.1 118.0 56.7 79.8 222.3 136.3 90.9 95.9 55.1 121.8 125.9 90.4 159.6 53.0 164.7 166.9 104.2 91.5 58.4 110.6 73.4 29.5 94.9 51.2 147.4 87.9 121.6 123.0 147.8 115.2 97.6 136.7 56.7 49.7 138.8 33.3 105.5 25.8 45.1 45.6 61.9 81.1 43.0 75.8 115.3 65.2 73.8 80.9 26.4 67.2 41.2 29.9 102.8 80.6 97.0 36.7 41.9 177.7 98.7 240.8 67.7 215.3 156.2 45.4 125.1 58.3 142.7 232.4 113.0 1.7 25.7 12.5 5.2 28.1 2.8 3.5 4.8 4.9 18.1 3.3 3.4 5.3 3.6 2.1 20.8 7.0 3.1 14.5 5.9 6.9 7.9 8.4 7.1 9.1 12.1 9.3 12.3 7.6 18.9 12.6 35.0 19.2 23.5 11.1 10.3 19.5 7.0 10.4 10.8 3.7 8.8 9.5 11.2 10.0 15.5 11.0 6.2 7.9 28.6 14.7 0.0 13.1 3.6 8.5 28.5 29.3 5.4 10.3 10.9 8.2 76.2 30.9 20.9 13.6 8.8 20.3 7.9 14.2 91.0 13.5 9.9 15.1 4.1 70.7 24.1 3.1 19.0 59.6 17.8 19.7 26.6 2.3 10.3 6.6 12.8 10.4 7.6 21.8 6.0 9.5 9.5 4.4 8.7 3.6 13.1 9.5 24.3 2.5 13.1 13.8 20.9 8.3 12.0 24.9 18.2 8.4 COLGALT2 "C1orf17, GLT25D2, KIAA0584" ENSG00000198756 "Collagen beta(1-O)galactosyltransferase 2" Q8IYK4 1 183929854-184037729 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 4 "brain: 50.6" "Cell type enhanced" "Detected in many" "Astrocytes: 53.5;Excitatory neurons: 79.9;Inhibitory neurons: 71.5;Late spermatids: 76.2;Oligodendrocyte precursor cells: 115.1;Oligodendrocytes: 359.3" "Cancer enhanced" "Detected in many" "glioma: 11.5" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 30 "basophil: 11.1" "Lineage enriched" "Detected in single" 30 "granulocytes: 11.1" "Cell line enhanced" "Detected in many" "Hep G2: 17.1;OE19: 13.8;SK-MEL-30: 18.6;U-251 MG: 18.0;WM-115: 22.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031749, HPA031750" Approved Approved Nucleoplasm,Vesicles "Intracellular and membrane" NA NA "Cluster 34: Basophils - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 17: WM-115 - Nervous system development" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm Vesicles "HPA031749: AB_10599298, HPA031750: AB_10611252" "unprognostic (5.44e-3)" "unprognostic (3.08e-1)" "unprognostic (6.29e-5)" "unprognostic (2.08e-1)" "unprognostic (4.41e-2)" "unprognostic (1.54e-1)" "unprognostic (1.16e-1)" "unprognostic (1.09e-2)" "unprognostic (2.52e-1)" "unprognostic (2.00e-1)" "unprognostic (2.25e-1)" "unprognostic (1.19e-1)" "unprognostic (5.13e-9)" "unprognostic (1.53e-2)" "unprognostic (1.92e-1)" "unprognostic (3.21e-2)" "unprognostic (3.80e-2)" 1.7 6.4 15.7 0.8 29.3 1.1 1.5 22.7 18.6 1.0 0.0 4.3 0.5 1.8 3.1 0.7 2.8 2.3 11.4 16.5 17.3 0.8 0.2 3.7 0.3 26.8 24.0 1.3 2.3 0.5 2.2 0.1 28.7 5.3 0.9 3.5 2.9 2.2 8.8 0.3 1.0 1.7 20.2 0.5 1.9 3.5 25.8 0.3 3.3 6.3 0.5 1.8 1.5 50.6 0.1 0.0 5.7 0.4 3.0 4.4 0.1 1.8 0.7 0.8 1.0 2.8 0.2 0.0 0.5 4.4 1.1 0.0 5.6 0.0 1.4 6.6 3.3 0.4 0.0 17.1 0.1 6.0 0.1 2.6 0.0 0.8 0.1 8.4 0.0 0.2 5.7 7.2 6.1 0.2 0.3 0.3 3.9 13.8 0.0 0.5 0.0 0.0 0.0 1.2 2.2 3.5 0.3 0.0 18.6 3.7 0.0 0.3 0.1 0.7 0.7 0.1 18.0 10.8 0.1 0.1 0.5 2.8 22.5 11.1 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 15.7 29.3 22.7 18.6 16.5 17.3 26.8 24.0 28.7 20.2 25.8 50.6 0.1 0.0 0.0 53.5 0.0 0.4 0.5 0.0 0.0 4.4 0.3 0.3 3.5 0.0 0.0 0.0 0.0 0.1 4.1 0.0 0.0 0.6 40.3 0.2 0.5 0.9 0.0 1.3 79.9 0.0 0.0 9.9 1.5 0.5 0.0 0.2 0.0 0.1 0.3 0.0 71.5 0.1 0.0 0.3 9.5 76.2 2.1 0.9 1.8 4.7 0.0 5.7 8.2 115.1 359.3 1.2 0.0 4.1 1.9 0.2 0.0 0.3 0.0 0.4 13.1 2.3 3.1 0.3 1.3 0.0 0.4 0.0 4.5 0.4 0.0 0.4 COMT ENSG00000093010 Catechol-O-methyltransferase P21964 22 19941371-19969975 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Catecholamine metabolism, Neurotransmitter degradation" "Methyltransferase, Transferase" "FDA approved drug targets, Schizophrenia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 885.9;Syncytiotrophoblasts: 648.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "MCF7: 818.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001169, CAB011233" Enhanced Enhanced "Endoplasmic reticulum,Vesicles" NA NA 43000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 15: Liver - Metabolism" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 47: Cytotrophoblasts - Unknown function" Vesicles "Endoplasmic reticulum" "CAB011233: , HPA001169: AB_1078402" "unprognostic (5.20e-2)" "unprognostic (2.73e-2)" "unprognostic (3.08e-2)" "prognostic favorable (3.68e-4)" "unprognostic (2.99e-2)" "unprognostic (2.32e-3)" "unprognostic (5.54e-3)" "unprognostic (9.14e-2)" "unprognostic (1.39e-1)" "unprognostic (1.40e-1)" "unprognostic (2.14e-3)" "prognostic favorable (5.67e-4)" "prognostic unfavorable (9.76e-4)" "unprognostic (2.27e-1)" "unprognostic (7.09e-2)" "unprognostic (3.97e-1)" "unprognostic (1.07e-2)" 78.1 180.7 99.3 39.6 108.9 71.8 85.5 114.4 140.4 105.3 119.6 80.1 55.0 76.9 47.7 198.0 65.2 60.3 81.7 96.6 107.4 94.2 292.3 93.3 49.7 117.4 107.9 107.4 74.0 61.5 48.7 116.9 117.3 87.2 20.7 17.2 133.7 70.5 98.6 119.7 64.1 38.3 109.2 63.6 99.8 51.7 102.7 26.9 59.1 49.9 26.0 86.9 124.1 124.3 131.3 131.7 15.0 128.3 141.2 122.5 6.0 143.9 178.8 120.3 133.6 112.1 148.6 51.7 62.7 208.9 48.6 172.9 23.6 152.0 26.2 115.1 163.4 92.5 65.1 267.1 265.1 155.0 35.3 159.2 180.7 104.3 101.3 116.6 113.2 82.0 383.2 109.4 100.6 818.5 63.4 267.9 32.4 361.1 42.9 88.2 127.9 72.8 129.0 404.5 60.4 53.8 47.7 405.7 125.7 7.6 84.0 436.6 137.5 212.7 82.2 71.0 109.6 37.5 18.0 41.2 236.0 211.3 152.5 62.2 312.2 59.6 77.9 218.1 64.0 56.8 52.6 62.6 251.5 57.8 45.5 51.7 12.0 73.5 151.5 291.4 72.6 178.6 99.3 108.9 114.4 140.4 96.6 107.4 117.4 107.9 117.3 109.2 102.7 124.3 99.1 125.0 88.1 22.9 33.1 102.1 231.9 248.1 188.4 73.4 174.9 218.4 41.9 104.4 162.7 152.6 10.4 885.9 80.1 53.0 320.8 201.0 4.6 59.1 72.2 86.7 84.5 70.0 16.8 193.0 113.5 103.1 46.4 46.9 71.7 95.7 77.1 262.0 311.4 25.2 17.2 97.7 191.2 177.0 107.7 13.3 134.2 137.0 240.1 20.6 137.0 158.7 41.2 25.1 45.7 170.2 108.8 179.8 45.5 132.4 179.9 73.8 135.8 43.2 138.1 143.3 113.1 8.4 5.7 236.4 123.5 648.5 41.8 222.0 122.3 206.6 COP1 "CFAP78, FAP78, FLJ10416, RFWD2, RNF200" ENSG00000143207 "COP1 E3 ubiquitin ligase" Q8NHY2 1 175944831-176207286 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 28.1;Extravillous trophoblasts: 33.5;Syncytiotrophoblasts: 31.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 15: RT4 - Unknown function" "Cluster 7: Non-specific - Mitochondria" "unprognostic (1.99e-1)" "unprognostic (3.76e-2)" "unprognostic (4.17e-2)" "prognostic unfavorable (3.96e-4)" "unprognostic (2.95e-2)" "unprognostic (4.33e-1)" "unprognostic (2.01e-2)" "unprognostic (1.10e-1)" "unprognostic (2.78e-2)" "unprognostic (3.52e-2)" "unprognostic (9.24e-2)" "unprognostic (1.67e-1)" "unprognostic (1.33e-2)" "unprognostic (6.68e-2)" "unprognostic (7.01e-2)" "unprognostic (1.59e-1)" "unprognostic (1.55e-1)" 14.2 9.5 5.9 12.0 7.1 16.8 12.7 11.4 9.1 12.1 8.4 18.1 13.8 11.8 9.8 14.2 9.4 9.5 9.8 8.5 5.9 12.4 16.6 12.5 15.7 4.6 5.0 8.7 13.2 10.5 8.0 11.2 5.0 10.1 16.7 8.6 13.1 8.5 13.6 17.5 13.9 11.0 5.7 16.7 13.7 15.6 6.1 14.9 10.6 7.4 16.8 14.7 11.9 8.8 35.3 17.5 22.1 13.8 23.0 22.6 56.1 21.7 22.0 17.7 18.6 30.0 28.1 59.4 25.8 20.9 18.9 32.3 16.9 27.0 17.7 23.7 17.0 22.6 19.4 28.0 18.9 49.2 33.0 16.8 28.9 17.6 19.8 17.9 26.6 21.7 43.9 24.9 24.8 42.5 27.0 28.2 47.4 55.8 2.0 26.1 20.4 40.2 26.8 93.7 22.6 41.6 27.8 44.9 35.9 37.4 32.1 69.1 40.4 19.4 16.1 28.3 23.4 35.3 62.7 49.8 19.1 26.7 26.9 8.5 3.0 12.0 1.9 3.7 1.4 1.7 2.0 1.4 2.1 1.5 2.7 2.0 14.1 0.6 3.4 1.1 1.7 1.0 5.9 7.1 11.4 9.1 8.5 5.9 4.6 5.0 5.0 5.7 6.1 8.8 15.8 22.4 14.5 0.0 4.4 0.0 0.0 0.0 0.0 0.0 15.4 10.9 0.0 0.0 3.1 9.2 0.0 28.1 12.2 0.0 21.5 14.8 0.0 17.9 14.6 7.2 0.0 0.0 0.0 22.7 33.5 7.4 0.0 20.1 7.6 18.1 0.0 0.0 22.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.0 0.0 0.0 10.3 0.0 0.0 0.0 0.0 21.8 0.0 0.0 3.1 0.0 0.0 22.1 4.4 0.0 0.0 0.0 7.7 0.0 0.0 0.0 0.0 31.3 6.7 13.8 0.0 0.0 COQ2 "CL640, FLJ26072" ENSG00000173085 "Coenzyme Q2, polyprenyltransferase" Q96H96 4 83261536-83284914 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Isoprene biosynthesis, Ubiquinone biosynthesis" Transferase "Disease variant, Neurodegeneration, Parkinsonism, Primary mitochondrial disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "tongue: 37.5" "Cell type enhanced" "Detected in many" "Hofbauer cells: 50.7;Kupffer cells: 53.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA056599, HPA068727" Approved Approved Cytosol NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 3: HMC-1 - Innate immune response" "Cluster 12: Non-specific - Cell cycle regulation" Cytosol "HPA056599: AB_2683184, HPA068727: AB_2686022" "unprognostic (8.26e-2)" "unprognostic (7.40e-3)" "unprognostic (3.95e-3)" "unprognostic (1.55e-1)" "unprognostic (9.22e-2)" "unprognostic (5.59e-2)" "unprognostic (1.26e-2)" "unprognostic (1.52e-1)" "unprognostic (4.09e-1)" "unprognostic (4.16e-2)" "unprognostic (2.08e-2)" "unprognostic (2.77e-3)" "unprognostic (1.56e-2)" "unprognostic (3.73e-1)" "unprognostic (1.40e-1)" "unprognostic (7.82e-2)" "unprognostic (2.46e-1)" 6.0 17.0 2.8 8.0 3.2 11.8 5.8 3.5 3.3 7.9 3.6 14.2 9.5 6.3 7.5 10.4 4.4 4.3 15.0 3.0 3.5 5.6 13.6 7.9 6.4 3.6 3.5 6.5 6.5 6.0 4.0 8.4 3.8 6.6 14.2 4.0 7.8 5.0 29.1 10.8 9.1 6.9 4.1 10.1 5.5 3.5 3.9 3.6 5.7 37.5 7.1 7.9 6.5 4.9 26.1 14.7 14.1 27.4 10.5 11.9 9.7 16.1 27.0 29.7 34.4 10.5 38.7 17.2 11.7 28.4 24.6 18.6 23.9 26.0 38.7 17.2 14.8 15.3 22.3 15.4 11.7 31.3 73.5 15.9 16.3 14.2 24.8 8.9 30.7 9.7 10.0 21.4 29.3 27.4 8.6 21.7 10.9 30.6 19.9 14.1 11.4 22.1 45.4 13.8 10.3 6.3 19.0 24.5 9.2 6.7 15.4 18.8 21.0 14.6 14.6 11.1 23.4 5.7 5.2 10.2 29.5 36.8 20.2 2.1 28.8 4.0 2.7 26.8 1.9 6.2 3.0 2.5 21.1 6.9 2.1 3.2 9.8 6.7 33.5 11.2 4.1 13.6 2.8 3.2 3.5 3.3 3.0 3.5 3.6 3.5 3.8 4.1 3.9 4.9 5.4 0.0 4.2 15.7 11.5 6.6 12.4 9.8 4.6 5.9 6.3 5.6 19.5 2.8 10.7 9.2 0.0 25.4 7.1 14.0 31.3 6.7 0.8 7.6 19.5 6.1 4.8 14.1 12.8 10.8 30.0 9.0 6.6 9.2 0.0 17.2 9.3 15.0 50.7 1.7 20.1 15.3 8.2 53.2 7.9 0.8 3.7 25.2 7.2 33.7 21.8 12.6 6.2 25.6 15.6 5.4 15.4 4.9 4.3 12.6 11.0 9.9 6.2 4.8 0.0 7.3 9.7 18.1 19.7 16.7 12.6 12.4 9.6 35.5 26.7 12.9 COQ3 bA9819.1 ENSG00000132423 "Coenzyme Q3, methyltransferase" Q9NZJ6 6 99369401-99394195 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubiquinone biosynthesis" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "tongue: 51.1" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 42.8;Distal tubular cells: 33.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031273, HPA031274" Enhanced Approved Nucleoplasm,Mitochondria NA NA "Cluster 44: Non-specific - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm Mitochondria "HPA031273: AB_10611107, HPA031274: AB_10602176" "unprognostic (1.81e-2)" "unprognostic (2.69e-2)" "unprognostic (1.45e-2)" "unprognostic (4.62e-2)" "unprognostic (2.41e-2)" "unprognostic (2.16e-2)" "unprognostic (1.48e-3)" "unprognostic (1.76e-1)" "unprognostic (3.40e-1)" "unprognostic (8.77e-2)" "unprognostic (9.78e-2)" "unprognostic (1.09e-1)" "prognostic favorable (6.86e-5)" "unprognostic (4.61e-2)" "unprognostic (1.81e-1)" "unprognostic (5.45e-2)" "unprognostic (1.08e-1)" 6.4 10.1 13.4 5.2 14.3 4.6 8.6 14.7 18.0 5.6 13.7 10.7 8.2 5.2 7.6 9.3 5.1 3.5 30.9 13.8 13.9 12.7 15.1 3.5 5.6 13.8 14.0 6.8 6.6 14.2 8.5 3.0 13.9 7.7 12.5 11.9 9.6 8.4 37.3 6.9 6.6 6.3 13.7 6.4 7.4 3.0 13.8 7.9 5.2 51.1 7.1 6.8 6.5 13.7 20.2 11.4 13.5 19.2 8.6 9.6 18.4 17.0 10.5 25.2 29.0 15.9 8.5 19.6 11.1 12.8 16.3 18.3 22.7 26.6 30.6 21.0 29.1 24.1 15.5 17.1 11.3 35.0 9.0 6.1 16.0 14.9 14.9 5.5 15.6 23.8 37.2 14.5 13.6 19.8 15.5 29.0 16.4 19.7 21.7 7.5 13.8 26.1 19.9 17.3 21.0 11.2 11.8 18.0 22.9 9.0 22.1 22.8 5.6 10.9 16.0 17.0 26.4 5.1 10.0 30.9 14.0 33.6 16.4 14.1 2.9 2.4 5.0 6.9 5.8 5.6 6.4 8.1 7.3 2.5 10.5 7.8 0.4 10.1 6.1 4.9 5.2 4.7 13.4 14.3 14.7 18.0 13.8 13.9 13.8 14.0 13.9 13.7 13.8 13.7 4.7 3.2 3.7 6.5 3.9 4.5 6.8 26.1 7.4 8.1 5.0 6.3 42.8 5.7 11.2 3.7 0.0 14.0 2.2 3.7 33.2 11.5 0.5 3.5 4.9 5.5 0.0 8.2 10.6 10.5 13.3 5.9 3.6 2.6 1.3 6.6 3.3 8.6 6.8 6.7 13.2 7.3 24.4 1.3 3.5 0.3 8.1 2.4 5.4 1.0 2.0 13.2 4.1 4.5 7.6 9.2 5.8 6.0 4.7 2.4 5.2 12.0 4.9 8.7 6.6 6.5 10.6 3.6 10.9 8.0 4.3 6.3 3.7 11.1 9.8 4.7 COQ5 MGC4767 ENSG00000110871 "Coenzyme Q5, methyltransferase" Q5HYK3 12 120503279-120534434 "Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Ubiquinone biosynthesis" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049487 Approved Uncertain Nucleoli,Mitochondria NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 39: Non-specific - Basic cellular processes" Nucleoli Mitochondria "HPA049487: AB_2680789" "unprognostic (1.46e-1)" "unprognostic (1.99e-2)" "unprognostic (1.32e-1)" "unprognostic (6.30e-3)" "unprognostic (2.00e-1)" "unprognostic (1.66e-1)" "unprognostic (1.88e-1)" "unprognostic (1.60e-1)" "unprognostic (2.01e-2)" "unprognostic (6.20e-2)" "unprognostic (1.62e-1)" "unprognostic (8.37e-2)" "unprognostic (3.79e-2)" "unprognostic (2.02e-1)" "unprognostic (7.73e-2)" "unprognostic (2.00e-2)" "unprognostic (3.88e-2)" 22.7 29.9 22.3 15.9 25.3 11.3 24.1 24.5 29.0 19.7 26.7 24.7 23.4 17.9 23.0 20.4 22.2 14.4 40.7 22.1 23.4 38.9 60.7 15.4 23.3 24.9 24.2 20.5 20.6 21.6 18.1 23.3 24.8 18.9 24.7 26.3 22.4 15.8 98.5 17.6 20.0 18.2 22.8 21.1 19.3 24.7 24.3 22.3 25.7 69.2 23.4 17.2 17.6 29.5 35.7 56.1 49.2 14.2 63.5 48.5 33.7 42.3 27.6 42.5 26.9 22.5 29.2 35.6 48.8 44.7 29.9 37.7 44.2 47.2 43.3 45.4 26.3 47.4 35.0 37.8 51.8 52.2 28.7 46.8 50.2 40.0 46.1 66.0 38.0 67.5 47.4 25.3 49.7 46.9 30.3 60.0 43.2 25.4 43.2 55.9 49.8 52.0 55.2 26.7 37.0 29.8 30.7 15.5 58.3 51.2 77.8 42.6 37.9 29.1 33.4 21.8 28.5 53.9 48.5 40.5 33.3 48.9 35.8 28.6 44.3 32.3 39.7 44.9 39.0 45.6 42.4 43.2 61.0 52.7 56.8 45.5 9.3 60.6 43.5 40.3 57.2 54.4 22.3 25.3 24.5 29.0 22.1 23.4 24.9 24.2 24.8 22.8 24.3 29.5 14.4 12.8 12.8 7.2 15.5 7.8 11.5 33.5 10.8 12.6 17.5 15.2 30.5 18.6 18.1 14.7 14.6 73.0 12.9 16.1 46.9 32.3 59.8 17.8 12.1 15.4 15.0 17.5 5.7 20.0 45.6 16.5 11.7 11.3 17.2 24.0 15.4 42.4 46.3 5.0 7.8 17.0 22.4 12.8 10.1 23.1 16.4 13.6 23.2 3.7 29.0 18.0 23.7 6.6 17.5 11.0 23.9 18.8 11.0 11.2 35.8 66.7 22.4 15.6 6.6 16.3 14.4 34.7 14.8 14.3 8.9 58.3 15.0 32.8 28.1 10.9 COX10 ENSG00000006695 "Cytochrome c oxidase assembly factor heme A:farnesyltransferase COX10" Q12887 17 14069490-14231736 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Heme biosynthesis" Transferase "Disease variant, Leigh syndrome, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 44.5;tongue: 44.3" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 88.2;Late spermatids: 81.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA032005, HPA032006" Supported Supported Nucleoli,Mitochondria,Cytosol NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 8: Non-specific - Mitochondria" "Cluster 12: NES - Nervous system development" "Cluster 25: Spermatids - Spermatogenesis" Mitochondria "Nucleoli, Cytosol" "HPA032005: AB_10603560, HPA032006: AB_10670554" "unprognostic (6.17e-2)" "unprognostic (3.14e-1)" "unprognostic (1.41e-2)" "unprognostic (4.35e-2)" "unprognostic (1.86e-1)" "unprognostic (2.03e-1)" "unprognostic (1.31e-1)" "unprognostic (7.40e-2)" "unprognostic (6.27e-3)" "unprognostic (1.07e-1)" "unprognostic (9.46e-3)" "unprognostic (6.46e-2)" "prognostic favorable (4.32e-6)" "prognostic favorable (8.73e-4)" "unprognostic (8.82e-2)" "unprognostic (1.02e-2)" "unprognostic (8.71e-2)" 7.1 7.5 3.1 5.4 2.9 10.4 6.0 4.1 4.4 5.8 4.3 12.5 12.5 5.2 4.4 10.9 5.6 4.2 27.9 3.3 3.9 11.6 10.6 4.4 5.8 3.8 3.5 4.5 9.9 9.6 3.3 7.0 3.5 5.6 12.3 5.6 7.2 5.5 44.5 7.4 10.1 7.2 3.0 4.8 9.3 21.1 4.0 5.4 6.2 44.3 7.5 8.5 6.6 3.6 10.1 19.7 7.7 11.9 7.7 5.6 19.5 12.3 8.4 21.9 14.6 16.3 6.6 23.5 9.8 13.0 6.8 20.2 16.6 16.3 17.3 13.1 15.7 14.5 12.4 20.0 14.2 15.5 12.3 9.8 19.5 14.0 17.6 7.9 11.4 15.8 20.4 8.2 9.5 13.1 13.5 10.5 12.8 37.6 9.5 10.3 28.8 18.5 15.2 20.1 5.2 9.8 12.0 18.5 16.5 36.1 9.6 9.2 9.9 8.9 8.0 9.9 15.8 10.1 15.6 11.2 14.9 15.7 11.9 3.8 11.3 4.4 9.8 16.1 10.6 13.2 11.3 10.5 14.9 9.2 11.9 11.5 1.2 10.0 13.9 4.6 20.1 11.0 3.1 2.9 4.1 4.4 3.3 3.9 3.8 3.5 3.5 3.0 4.0 3.6 5.9 0.0 14.7 25.8 9.6 9.7 9.5 9.8 14.2 7.5 8.7 7.4 88.2 5.7 7.3 11.0 10.4 19.7 5.7 13.8 41.1 9.1 41.1 9.6 9.6 7.8 12.6 13.3 33.5 8.7 17.5 8.8 16.3 9.4 5.1 7.5 3.9 9.6 10.8 0.0 43.0 16.4 8.2 4.4 4.7 81.0 2.1 6.7 5.4 22.5 6.3 4.6 8.2 34.7 26.9 8.8 11.4 6.8 12.5 8.7 26.6 17.8 5.8 12.2 0.0 5.2 12.5 22.8 19.2 19.4 10.4 16.1 8.6 6.6 18.9 13.7 CPT1A "CPT1, CPT1-L, L-CPT1" ENSG00000110090 "Carnitine palmitoyltransferase 1A" P50416 11 68754620-68844410 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Fatty acid metabolism, Lipid metabolism, Transport" "Acyltransferase, Transferase" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 110.0;Hepatocytes: 108.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008835 Supported Supported Mitochondria NA NA 45000 "Cluster 2: Granulocytes - Unknown function" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 25: RPMI-8226 - Immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" Mitochondria "HPA008835: AB_1078563" "prognostic unfavorable (3.84e-4)" "unprognostic (1.38e-3)" "unprognostic (3.04e-3)" "unprognostic (2.46e-2)" "unprognostic (1.45e-1)" "unprognostic (7.25e-2)" "unprognostic (2.17e-1)" "unprognostic (4.99e-2)" "unprognostic (2.72e-1)" "unprognostic (1.47e-2)" "unprognostic (2.92e-2)" "unprognostic (2.34e-1)" "prognostic favorable (2.67e-7)" "unprognostic (9.76e-2)" "unprognostic (1.06e-1)" "unprognostic (1.49e-1)" "unprognostic (2.46e-3)" 24.3 27.7 16.0 22.3 18.4 38.9 22.7 20.2 17.3 20.4 32.0 67.4 70.7 25.1 7.3 22.0 25.4 27.7 25.4 14.7 17.7 38.4 67.9 25.3 15.9 20.6 22.0 18.3 23.6 27.6 14.3 18.4 19.3 20.3 44.6 22.6 26.0 21.9 9.9 17.0 71.3 34.9 15.9 27.4 35.6 13.5 22.1 14.0 15.4 14.3 12.3 18.7 18.0 13.9 29.4 50.9 7.3 48.6 31.2 28.0 2.1 22.9 18.8 17.7 3.6 2.0 96.0 0.1 82.2 60.4 62.2 93.5 63.9 13.6 5.3 46.8 6.3 71.5 52.3 24.0 46.4 41.9 82.6 29.2 6.6 35.5 21.4 24.1 63.5 28.2 7.6 56.8 16.5 83.6 34.4 73.7 0.8 149.7 53.2 94.7 1.2 127.1 41.7 71.7 1.0 31.8 63.0 119.9 20.2 4.8 107.4 40.0 64.5 38.3 0.9 77.7 33.5 43.9 60.1 29.2 40.3 30.3 42.8 8.2 6.6 9.5 7.3 7.7 4.2 1.9 4.4 4.4 4.4 2.0 2.7 5.5 3.2 4.9 6.7 10.4 2.8 2.7 16.0 18.4 20.2 17.3 14.7 17.7 20.6 22.0 19.3 15.9 22.1 13.9 44.4 38.5 28.8 35.6 13.5 9.4 11.0 9.0 28.5 4.8 9.6 7.6 25.5 22.8 18.0 23.9 64.6 15.9 39.3 110.0 19.6 13.8 14.7 33.2 22.6 30.4 16.2 30.9 5.6 9.5 3.9 16.6 31.1 56.7 29.7 23.0 40.7 108.3 15.7 1.7 5.7 48.9 10.2 39.1 11.5 43.9 9.6 24.6 0.0 28.1 31.4 12.7 23.7 7.1 1.7 8.5 43.4 32.0 28.6 9.6 83.4 11.8 23.8 43.0 39.5 18.3 21.1 14.5 10.0 14.8 7.7 7.8 24.0 17.3 67.4 9.2 CPT1B "CPT1-M, M-CPT1" ENSG00000205560 "Carnitine palmitoyltransferase 1B" Q92523 22 50568861-50578465 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Fatty acid metabolism, Lipid metabolism, Transport" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 5 "heart muscle: 242.7;skeletal muscle: 144.5;testis: 80.7;tongue: 228.0" "Group enriched" "Detected in many" 4 "Early spermatids: 45.4;Late spermatids: 109.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" HPA079265 Enhanced NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 38: Heart - Muscle contraction" "Cluster 20: HeLa - Mitochondria" "Cluster 25: Spermatids - Spermatogenesis" "HPA079265: " "unprognostic (1.66e-1)" "unprognostic (2.99e-1)" "unprognostic (6.71e-3)" "unprognostic (2.53e-2)" "unprognostic (1.36e-1)" "unprognostic (1.18e-3)" "unprognostic (8.89e-2)" "unprognostic (7.16e-2)" "unprognostic (5.01e-2)" "unprognostic (9.50e-2)" "unprognostic (1.10e-3)" "unprognostic (9.76e-3)" "unprognostic (7.37e-2)" "unprognostic (4.98e-3)" "unprognostic (1.14e-1)" "unprognostic (8.43e-2)" "unprognostic (3.15e-5)" 10.3 9.3 13.8 11.4 15.5 13.4 15.7 17.4 17.4 7.7 12.2 14.0 13.5 4.6 10.3 16.6 7.3 6.1 242.7 13.6 14.7 25.1 25.6 10.5 14.4 16.7 14.6 5.0 18.3 34.1 23.5 8.1 15.8 15.7 10.6 17.1 13.1 3.4 144.5 14.1 22.2 3.6 13.6 27.5 13.0 80.7 16.1 9.8 26.7 228.0 13.1 9.9 10.3 17.8 8.2 7.7 24.5 9.0 5.3 3.1 17.5 0.3 3.1 4.1 4.5 3.6 7.2 16.3 2.2 2.0 6.0 13.6 12.9 2.9 3.6 6.5 14.2 8.0 26.2 3.9 1.4 8.5 22.3 1.8 22.0 2.9 4.8 15.0 0.7 11.4 2.9 27.8 3.9 11.9 2.9 16.3 5.2 4.3 4.9 15.2 7.8 3.5 10.3 19.6 6.6 12.7 5.7 9.7 10.9 14.8 10.8 17.9 1.6 11.4 11.4 7.4 2.8 22.3 5.5 8.7 4.9 15.2 8.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 13.8 15.5 17.4 17.4 13.6 14.7 16.7 14.6 15.8 13.6 16.1 17.8 0.5 0.0 11.0 0.0 0.8 0.3 0.0 1.0 1.8 1.9 2.2 1.0 3.7 1.5 1.5 3.7 2.1 0.5 0.2 5.6 0.0 2.2 45.4 0.9 0.1 1.0 0.0 0.0 0.0 2.1 0.6 1.4 5.6 0.4 7.0 0.1 0.4 2.1 0.6 3.3 0.0 5.2 0.0 0.6 0.8 109.3 0.3 1.0 1.8 0.0 6.3 0.4 0.0 0.0 0.0 1.0 6.4 0.7 0.4 0.0 3.5 0.5 3.7 2.0 0.0 0.9 0.3 16.3 2.4 1.0 0.3 0.4 1.2 0.0 4.2 0.1 CPT1C "CATL1, CPT1P, CPTIC, FLJ23809" ENSG00000169169 "Carnitine palmitoyltransferase 1C" Q8TCG5 19 49690898-49713731 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Fatty acid metabolism, Lipid metabolism" "Acyltransferase, Transferase" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 19.2;pituitary gland: 28.4" "Cell type enhanced" "Detected in many" "Bipolar cells: 43.4;Excitatory neurons: 34.0;Horizontal cells: 32.0;Inhibitory neurons: 28.1;Late spermatids: 29.7;Oligodendrocyte precursor cells: 21.1" "Cancer enriched" "Detected in many" 5 "glioma: 9.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 40.2;AN3-CA: 33.2;SCLC-21H: 27.4;SH-SY5Y: 70.1;U-87 MG: 29.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA014529, HPA063621" Approved Approved Centrosome NA NA "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 56: Bipolar cells - Visual perception" Centrosome "HPA014529: AB_1847206, HPA063621: AB_2732706" "unprognostic (1.09e-1)" "unprognostic (6.25e-2)" "unprognostic (1.03e-2)" "unprognostic (5.18e-3)" "unprognostic (1.73e-1)" "unprognostic (1.46e-3)" "unprognostic (1.39e-1)" "unprognostic (2.54e-1)" "unprognostic (1.06e-1)" "unprognostic (2.49e-1)" "prognostic favorable (1.84e-4)" "unprognostic (4.36e-1)" "unprognostic (1.92e-10)" "unprognostic (9.44e-4)" "unprognostic (3.35e-2)" "unprognostic (3.91e-1)" "unprognostic (4.72e-3)" 3.4 5.3 14.0 1.6 14.8 0.0 2.1 8.5 19.1 6.5 18.8 2.6 1.3 8.1 2.3 1.0 4.9 4.4 3.8 19.2 15.6 1.7 0.8 2.1 1.3 10.1 9.2 5.1 1.4 1.4 28.4 0.7 10.3 3.4 0.6 12.4 1.0 2.5 0.7 1.0 1.8 4.6 4.9 4.9 1.5 3.5 12.9 0.2 2.4 0.2 0.6 2.7 3.7 14.4 0.0 0.0 40.2 33.2 14.0 11.0 0.0 12.6 25.2 16.2 22.4 0.7 0.0 0.8 0.0 12.7 2.0 3.0 0.0 0.0 8.5 0.6 0.1 0.0 0.1 0.0 22.7 0.0 0.0 12.7 0.0 13.3 0.1 4.3 22.2 0.1 0.1 0.0 0.9 0.7 0.2 0.0 1.8 2.7 8.8 0.0 0.0 0.0 0.9 0.0 27.4 70.1 0.1 0.1 0.0 0.6 0.1 0.1 18.3 1.0 0.2 7.7 6.7 0.2 3.2 0.4 29.5 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.0 14.8 8.5 19.1 19.2 15.6 10.1 9.2 10.3 4.9 12.9 14.4 3.8 0.0 0.0 7.5 0.4 2.2 3.1 0.5 3.4 43.4 0.9 1.3 1.4 1.5 0.0 0.0 16.7 1.1 0.3 0.1 0.0 0.0 8.9 0.5 14.1 7.4 0.0 0.0 34.0 0.0 4.4 6.0 0.0 1.2 0.0 1.9 5.0 0.1 0.3 32.0 28.1 0.1 0.0 0.9 1.2 29.7 3.4 0.8 0.0 7.5 0.0 18.3 0.0 21.1 14.9 0.3 0.0 13.2 1.4 2.1 0.0 0.0 0.0 19.1 0.0 5.8 6.3 3.1 7.0 1.0 1.8 1.1 0.7 4.4 0.2 1.6 CPT2 "CPT1, CPTASE" ENSG00000157184 "Carnitine palmitoyltransferase 2" P23786 1 53196792-53214197 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism, Transport" "Acyltransferase, Transferase" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 91.2" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 85.1;Hepatocytes: 88.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028201, HPA028202, HPA028214" Enhanced Approved Nucleoplasm,Nucleoli,Mitochondria Yes No "Cluster 45: Eosinophils - Innate immune response" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 47: Cytotrophoblasts - Unknown function" "Nucleoplasm, Mitochondria" Nucleoli "HPA028201: AB_10599177, HPA028202: AB_10599942, HPA028214: AB_10601958" "unprognostic (2.43e-1)" "unprognostic (2.27e-1)" "prognostic favorable (5.27e-4)" "unprognostic (6.48e-2)" "unprognostic (1.88e-1)" "unprognostic (9.34e-2)" "unprognostic (6.48e-2)" "unprognostic (1.75e-2)" "unprognostic (2.86e-1)" "unprognostic (1.67e-1)" "unprognostic (3.00e-2)" "unprognostic (8.97e-2)" "prognostic favorable (1.46e-12)" "unprognostic (4.00e-2)" "unprognostic (2.06e-1)" "unprognostic (1.79e-2)" "unprognostic (2.95e-2)" 12.9 14.3 6.6 9.4 8.2 5.4 13.6 7.9 7.3 10.3 16.8 35.4 32.4 6.8 10.5 14.2 10.5 9.5 19.5 6.1 7.1 35.1 91.2 11.5 10.6 8.1 7.5 10.2 21.7 27.3 6.7 18.0 8.0 12.2 32.8 7.1 14.6 11.7 17.3 6.7 24.9 11.4 7.7 8.7 18.4 12.9 9.0 10.2 12.5 33.1 13.2 11.1 4.5 8.9 16.0 8.3 17.2 17.8 14.6 11.3 17.5 9.8 13.2 17.5 17.5 8.6 14.5 28.9 14.6 9.2 20.1 19.1 35.1 25.1 15.1 17.0 16.0 21.8 9.9 6.4 25.9 15.9 19.5 23.0 23.2 13.8 11.1 18.6 15.4 26.5 20.9 9.9 13.1 12.8 10.7 13.0 29.8 38.4 20.0 13.2 16.2 34.4 22.9 22.0 25.3 14.4 22.1 30.3 39.7 36.6 32.3 32.2 8.7 8.4 6.1 16.5 8.5 26.3 19.8 16.2 11.6 20.6 12.4 5.6 14.1 14.6 7.2 20.0 8.1 5.3 6.3 8.4 17.9 7.4 10.5 7.2 5.3 6.9 20.5 8.9 9.9 10.3 6.6 8.2 7.9 7.3 6.1 7.1 8.1 7.5 8.0 7.7 9.0 8.9 5.0 12.8 24.1 4.2 7.8 1.8 5.2 20.5 5.2 6.0 7.5 7.0 18.1 15.7 11.4 11.0 14.6 85.1 4.5 49.3 25.4 12.9 1.1 10.9 8.1 5.9 14.5 9.4 1.5 10.5 20.3 7.2 18.3 10.3 2.5 12.7 8.9 88.8 26.3 15.2 2.0 26.6 16.2 15.1 7.2 2.8 6.8 10.5 7.2 1.9 20.2 11.6 6.2 2.5 4.5 10.5 25.6 5.3 9.1 4.9 38.6 41.0 7.6 11.0 6.6 7.5 8.4 49.9 31.3 13.8 2.6 54.6 6.9 25.6 29.5 5.7 CRAT CAT1 ENSG00000095321 "Carnitine O-acetyltransferase" P43155 9 129094142-129111189 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Fatty acid metabolism, Lipid metabolism, Transport" "Acyltransferase, Transferase" Neurodegeneration "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 227.5;tongue: 201.3" "Cell type enhanced" "Detected in many" "Early spermatids: 181.2;Late spermatids: 521.8;Proximal enterocytes: 136.4;Spermatocytes: 123.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019230, HPA020260, HPA022815" Enhanced Approved "Nucleoplasm,Nuclear membrane" NA NA 8100 "Cluster 39: Non-specific - mRNA processing" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 6: T47d - Mammary gland" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoplasm, Nuclear membrane" "HPA019230: AB_1847212, HPA020260: AB_1847210, HPA022815: AB_2732427" "unprognostic (5.13e-2)" "unprognostic (9.79e-3)" "unprognostic (1.99e-2)" "prognostic favorable (2.36e-4)" "unprognostic (2.19e-1)" "unprognostic (1.14e-1)" "unprognostic (1.15e-2)" "unprognostic (2.18e-1)" "unprognostic (5.11e-2)" "unprognostic (3.24e-2)" "unprognostic (3.13e-3)" "unprognostic (2.03e-1)" "prognostic favorable (0.00e+0)" "unprognostic (1.38e-1)" "unprognostic (9.27e-2)" "unprognostic (1.26e-2)" "unprognostic (7.65e-2)" 36.1 51.3 26.4 5.4 26.6 9.0 29.2 27.0 33.8 31.7 27.5 36.1 33.0 24.8 4.0 37.3 23.1 6.6 68.2 25.1 27.8 46.9 151.2 15.2 3.2 28.8 28.2 23.0 107.1 26.3 12.3 6.6 30.6 42.2 4.2 1.7 32.8 8.9 227.5 29.6 37.2 6.8 26.7 15.2 34.0 146.4 30.2 3.1 21.5 201.3 1.6 31.3 27.5 24.4 0.1 39.3 10.7 21.3 13.4 25.9 17.0 15.0 16.6 18.9 12.0 7.8 14.0 1.5 9.2 25.9 23.2 6.7 2.2 4.9 7.2 23.6 0.3 7.3 19.1 30.4 34.1 0.0 26.1 26.3 0.0 15.7 0.9 15.8 26.2 7.2 3.6 5.7 20.0 9.1 0.5 15.9 2.8 32.0 18.0 16.8 21.8 12.2 18.0 0.6 4.2 12.1 0.0 7.1 4.8 3.4 49.7 5.5 22.6 23.0 1.6 32.1 15.4 25.5 22.6 0.1 28.8 4.2 16.8 1.6 8.4 3.5 3.2 5.5 6.7 1.5 4.4 4.3 8.6 1.3 2.6 3.1 1.1 4.4 5.6 3.9 4.5 6.1 26.4 26.6 27.0 33.8 25.1 27.8 28.8 28.2 30.6 26.7 30.2 24.4 10.5 6.4 3.7 5.5 4.9 3.2 4.7 10.8 0.6 1.5 9.7 8.1 57.8 21.5 8.2 3.7 2.1 45.9 6.0 64.5 17.6 22.6 181.2 3.5 15.7 12.9 15.5 17.4 5.3 22.4 55.6 19.3 16.8 9.9 7.0 12.9 14.6 65.7 20.7 1.7 6.1 23.6 14.2 13.9 10.5 521.8 22.1 12.4 5.4 6.5 8.3 15.5 6.2 3.5 4.0 11.6 47.6 24.5 9.6 9.3 136.4 52.0 2.8 1.3 6.6 10.5 15.7 123.5 8.6 57.4 4.5 50.3 7.6 20.1 29.3 13.8 CREBBP "CBP, KAT3A, RSTS, RTS" ENSG00000005339 "CREB binding protein" Q92793 16 3725054-3880713 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Biological rhythms, Host-virus interaction, Transcription, Transcription regulation" "Activator, Acyltransferase, Transferase" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004212, HPA055861" Supported Supported "Nucleoplasm,Nuclear bodies" No No "Cluster 1: Neutrophils - Mixed function" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 44: Endometrium - Transcription" Nucleoplasm "Nuclear bodies" "CAB004212: AB_626817, HPA055861: AB_2682948" "unprognostic (1.17e-1)" "unprognostic (8.51e-2)" "unprognostic (1.60e-1)" "unprognostic (1.63e-1)" "unprognostic (1.49e-1)" "unprognostic (5.09e-2)" "unprognostic (9.59e-3)" "unprognostic (6.98e-2)" "unprognostic (8.96e-2)" "unprognostic (1.08e-1)" "unprognostic (1.76e-1)" "unprognostic (2.84e-1)" "prognostic favorable (6.24e-5)" "unprognostic (1.47e-1)" "unprognostic (1.74e-1)" "unprognostic (3.97e-2)" "unprognostic (8.23e-2)" 17.4 10.6 5.8 17.1 5.2 52.9 16.8 25.4 11.5 20.9 3.7 18.8 12.5 26.5 12.4 16.5 22.4 16.6 14.4 5.9 3.1 12.0 14.3 15.9 17.6 8.9 6.8 37.3 29.7 18.5 11.3 16.9 2.9 16.1 14.1 13.8 17.2 16.2 29.6 21.0 16.4 19.6 0.4 21.0 16.3 33.2 7.9 29.1 23.3 28.9 20.7 16.6 16.5 6.4 12.3 31.0 39.3 17.4 23.5 23.1 20.4 17.4 28.9 29.2 28.2 28.2 22.4 33.7 20.1 33.3 18.7 23.2 45.7 14.2 32.9 57.5 18.5 26.6 29.2 17.9 26.0 26.9 36.5 20.7 14.2 32.5 38.9 18.0 22.3 17.0 30.9 44.8 16.0 42.0 17.9 13.0 32.3 11.7 12.7 83.4 31.1 26.1 11.2 16.2 32.6 21.5 29.5 28.7 16.8 25.3 25.6 25.9 34.7 35.5 35.2 18.4 16.0 20.8 24.3 63.7 7.2 15.8 25.6 1.9 1.1 0.9 1.7 1.5 0.8 3.7 0.8 1.3 0.7 2.1 0.8 1.1 6.7 1.4 2.9 1.5 0.8 0.9 5.8 5.2 25.4 11.5 5.9 3.1 8.9 6.8 2.9 0.4 7.9 6.4 48.1 44.8 51.6 91.1 38.3 56.2 31.0 16.0 27.3 34.2 34.4 25.7 41.2 40.0 28.0 11.0 25.0 17.4 50.1 31.2 5.9 20.9 43.0 37.2 56.4 35.7 15.0 33.4 88.7 20.3 11.3 39.5 32.1 63.5 30.4 53.1 32.5 29.5 20.9 28.6 89.8 25.3 18.3 44.0 42.8 80.2 56.5 49.0 17.8 87.1 52.5 34.5 43.3 111.6 101.2 27.5 19.5 51.1 35.6 39.8 25.2 10.9 28.2 17.6 46.0 75.8 44.9 35.1 42.2 34.6 58.8 30.8 44.2 36.2 24.6 44.2 CRLS1 "C20orf155, CLS1, dJ967N21.6, GCD10" ENSG00000088766 "Cardiolipin synthase 1" Q9UJA2 20 6006093-6040053 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 169.5" "Cell type enhanced" "Detected in all" "Early spermatids: 264.2;Hepatocytes: 208.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "Hep G2: 237.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 8: Non-specific - Mitochondria" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 29: Early spermatids - Spermatogenesis" "unprognostic (1.48e-1)" "unprognostic (2.97e-1)" "unprognostic (2.88e-1)" "unprognostic (8.56e-2)" "unprognostic (9.64e-3)" "unprognostic (1.89e-1)" "unprognostic (1.41e-2)" "unprognostic (2.65e-2)" "unprognostic (1.42e-1)" "unprognostic (2.00e-1)" "unprognostic (9.89e-3)" "unprognostic (2.78e-2)" "unprognostic (1.52e-2)" "unprognostic (1.83e-2)" "unprognostic (1.85e-1)" "unprognostic (9.54e-2)" "prognostic favorable (8.02e-4)" 50.1 55.1 14.7 16.9 14.9 28.4 33.2 14.4 17.9 24.0 16.7 32.3 59.2 18.9 19.9 18.5 24.1 19.9 82.8 14.5 14.7 57.8 169.5 27.1 16.5 15.5 15.9 21.2 37.4 28.3 15.8 17.9 15.3 32.6 32.9 15.5 27.5 25.8 86.0 15.1 40.9 23.7 15.3 14.5 46.5 27.8 16.9 16.9 27.2 79.5 18.3 25.8 17.7 15.4 71.7 46.5 27.9 40.0 83.1 74.9 34.5 43.6 50.9 38.8 46.8 61.5 44.4 75.8 31.4 52.6 73.3 45.0 54.6 70.9 57.6 21.9 39.9 99.5 17.0 237.4 59.6 99.7 32.4 44.6 59.4 41.5 73.5 36.8 57.3 40.3 76.4 31.6 44.2 25.9 63.6 90.1 55.4 154.8 42.4 42.3 44.6 80.7 61.8 22.1 50.3 43.4 44.8 98.7 78.1 27.5 35.8 59.6 39.2 45.9 33.4 48.7 59.0 33.8 79.1 79.9 17.6 79.5 43.9 0.0 1.2 0.6 1.2 0.9 2.2 2.3 0.7 0.8 1.3 1.1 1.4 0.8 0.0 1.7 0.5 1.6 0.8 0.4 14.7 14.9 14.4 17.9 14.5 14.7 15.5 15.9 15.3 15.3 16.9 15.4 18.8 22.4 47.6 22.2 26.4 33.8 41.4 19.4 31.9 12.9 35.8 27.7 108.0 64.3 16.2 36.8 4.2 45.1 19.5 36.3 64.6 27.9 264.2 29.7 26.2 22.7 28.6 58.0 37.0 28.8 64.1 33.8 52.0 29.7 14.7 31.6 22.5 208.7 34.2 11.8 28.7 50.7 4.1 40.0 24.1 99.5 30.4 31.9 26.6 32.8 28.9 40.5 25.7 39.7 34.3 28.4 49.1 24.5 41.8 117.7 75.7 141.0 15.0 12.9 13.1 29.2 25.6 23.0 18.4 37.7 27.8 36.3 23.3 32.3 82.9 48.6 CROT COT ENSG00000005469 "Carnitine O-octanoyltransferase" Q9UKG9 7 87345664-87399794 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters" "Fatty acid metabolism, Lipid metabolism, Transport" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 136.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "hTCEpi: 71.7;RT4: 72.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019052, HPA019364, HPA019365" Enhanced Approved Vesicles NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 15: RT4 - Unknown function" "Cluster 47: Cytotrophoblasts - Unknown function" Vesicles "HPA019052: AB_1847172, HPA019364: AB_1847173, HPA019365: AB_1847174" "unprognostic (2.80e-2)" "unprognostic (6.47e-2)" "unprognostic (1.75e-1)" "unprognostic (4.56e-2)" "unprognostic (1.70e-1)" "unprognostic (2.55e-2)" "unprognostic (1.84e-1)" "unprognostic (9.93e-3)" "unprognostic (2.13e-1)" "unprognostic (1.13e-1)" "unprognostic (9.84e-2)" "unprognostic (3.48e-1)" "prognostic favorable (2.55e-6)" "unprognostic (3.52e-2)" "unprognostic (1.34e-1)" "unprognostic (7.60e-3)" "prognostic favorable (4.02e-4)" 5.4 10.5 4.8 6.3 6.1 3.2 16.1 5.9 6.1 11.8 7.9 12.6 31.9 7.8 18.5 19.3 10.7 14.1 6.6 5.7 5.1 16.9 35.0 6.6 6.2 4.6 5.0 8.6 6.7 18.7 6.0 19.0 4.5 21.1 11.0 35.4 9.3 27.5 11.3 24.6 23.6 8.6 4.9 5.4 6.8 3.3 5.3 7.6 40.5 9.5 8.5 25.2 19.0 5.6 15.3 10.9 13.5 4.7 12.6 11.5 9.9 15.7 14.8 9.4 10.1 6.0 7.9 6.4 13.6 13.6 18.9 18.9 2.3 21.2 13.5 9.1 9.5 13.9 7.8 7.6 8.1 8.8 8.3 9.4 71.7 7.6 6.0 12.1 13.7 10.4 0.7 9.0 25.2 15.0 11.2 8.8 3.0 5.5 16.4 5.0 18.6 1.1 12.3 72.1 2.2 10.5 19.2 22.3 10.6 9.2 14.2 3.1 7.2 22.0 9.5 29.8 15.2 13.6 21.0 8.8 14.8 0.1 13.3 2.0 1.3 3.4 6.6 1.7 8.7 2.0 6.7 5.5 1.9 1.9 5.3 5.9 0.8 13.0 6.2 2.2 6.2 2.8 4.8 6.1 5.9 6.1 5.7 5.1 4.6 5.0 4.5 4.9 5.3 5.6 8.6 22.4 10.0 18.9 5.1 16.8 56.4 45.0 65.4 16.9 17.5 12.7 14.9 14.3 35.0 53.3 45.9 136.5 9.0 21.0 9.8 7.6 28.7 9.5 9.3 7.2 7.3 4.8 26.3 8.7 7.9 12.0 11.2 12.1 7.6 9.5 5.3 29.7 13.6 15.2 11.1 15.8 16.2 6.3 4.8 63.1 15.8 5.9 19.6 7.5 6.3 25.9 22.6 15.6 16.1 11.1 9.9 13.9 4.8 20.1 53.7 19.9 24.1 79.7 6.6 10.0 10.1 2.4 4.8 29.6 15.3 49.0 9.6 8.7 15.1 48.4 CRPPA "hCG_1745121, ISPD, Nip" ENSG00000214960 "CDP-L-ribitol pyrophosphorylase A" A4D126 7 16087525-16502504 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Nucleotidyltransferase, Transferase" "Congenital muscular dystrophy, Disease variant, Dystroglycanopathy, Limb-girdle muscular dystrophy, Lissencephaly" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "choroid plexus: 27.0" "Group enriched" "Detected in some" 4 "Cardiomyocytes: 8.0;Cytotrophoblasts: 3.5;Extravillous trophoblasts: 10.6;Syncytiotrophoblasts: 2.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in single" 29 "basophil: 13.8" "Lineage enriched" "Detected in single" 29 "granulocytes: 13.8" "Cell line enhanced" "Detected in many" "HEL: 9.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA053554 Approved "Nucleoplasm,Nucleoli fibrillar center" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 36: HEL - Hemostasis" "Cluster 24: Non-specific - Transcription regulation" "Nucleoli fibrillar center" Nucleoplasm "HPA053554: AB_2682185" "unprognostic (4.65e-3)" "unprognostic (5.92e-2)" "unprognostic (2.61e-1)" "unprognostic (9.41e-2)" "unprognostic (1.49e-2)" "unprognostic (1.29e-1)" "unprognostic (1.19e-1)" "unprognostic (7.07e-2)" "unprognostic (3.47e-2)" "unprognostic (3.39e-2)" "unprognostic (6.01e-2)" "unprognostic (2.07e-1)" "prognostic favorable (1.38e-11)" "unprognostic (4.01e-2)" "unprognostic (1.78e-4)" "unprognostic (6.26e-2)" "unprognostic (2.79e-1)" 1.1 1.2 1.3 0.8 1.8 1.6 0.9 0.7 3.7 1.3 27.0 1.0 0.6 1.0 0.5 0.5 0.9 1.1 2.6 3.8 1.1 2.9 4.1 1.0 1.4 0.8 0.8 0.7 1.5 1.1 0.7 1.0 0.8 1.0 1.2 1.2 1.2 0.8 1.5 1.2 0.6 1.2 0.2 0.9 3.5 2.2 3.2 1.2 0.8 1.3 1.4 1.1 0.5 2.0 0.4 2.2 1.0 1.6 1.0 1.3 6.8 1.5 1.4 1.5 1.3 2.2 1.9 4.3 3.2 2.7 0.9 2.5 1.2 0.0 2.9 1.5 0.9 9.6 1.4 0.7 1.5 1.9 2.4 2.2 0.8 1.6 0.4 0.9 1.2 3.0 3.2 0.2 4.2 0.7 3.0 1.2 1.8 1.1 0.5 1.1 1.9 0.2 2.1 0.8 1.5 0.9 1.4 2.1 1.7 2.5 1.6 2.0 2.0 1.9 1.5 0.4 1.7 0.4 0.0 4.8 1.5 2.3 2.2 13.8 0.1 0.4 0.2 0.0 0.1 0.2 0.1 0.2 0.0 0.4 0.3 0.2 0.4 0.4 0.1 0.3 0.1 0.0 1.3 1.8 0.7 3.7 3.8 1.1 0.8 0.8 0.8 0.2 3.2 2.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.0 0.0 0.0 0.0 0.0 3.5 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 10.6 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 2.9 0.0 0.0 0.0 0.0 CS ENSG00000062485 "Citrate synthase" O75390 12 56271699-56300391 "Citric acid cycle related proteins, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Tricarboxylic acid cycle" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 550.1;tongue: 600.7" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 239.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038460, HPA038461, CAB075750, CAB075751, CAB075752, CAB075753, CAB075754" Enhanced Enhanced Mitochondria NA NA 670000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 54: Cardiomyocytes - Muscle contraction" Mitochondria "CAB075750: AB_2665756, CAB075751: AB_2665757, CAB075752: AB_2665758, CAB075753: AB_2665759, CAB075754: AB_2665760, HPA038460: AB_2676023, HPA038461: AB_2676024" "unprognostic (7.67e-3)" "unprognostic (3.80e-1)" "unprognostic (2.59e-2)" "unprognostic (2.50e-2)" "unprognostic (2.70e-2)" "unprognostic (1.25e-1)" "unprognostic (6.09e-3)" "unprognostic (3.34e-2)" "unprognostic (2.43e-1)" "unprognostic (5.58e-2)" "unprognostic (2.56e-1)" "unprognostic (1.97e-2)" "prognostic favorable (1.17e-4)" "unprognostic (1.20e-1)" "unprognostic (2.09e-1)" "unprognostic (1.30e-2)" "unprognostic (2.02e-1)" 154.2 93.6 29.2 61.7 30.0 111.0 66.3 33.7 49.9 55.4 40.5 110.1 97.7 56.4 32.2 95.6 58.3 42.4 319.3 30.9 34.6 86.6 39.0 58.0 67.2 39.4 32.0 56.0 61.5 127.6 28.9 45.7 39.4 59.0 124.1 128.9 73.7 60.5 550.1 70.5 81.2 77.5 22.5 49.0 66.5 24.4 41.0 69.4 53.0 600.7 106.1 70.2 58.2 31.6 168.9 176.8 141.6 198.2 188.4 173.8 93.3 136.9 132.0 231.1 160.6 271.2 158.2 322.9 128.2 172.6 99.3 182.1 396.8 200.8 234.9 109.3 200.2 222.9 136.1 261.4 107.3 288.4 166.6 188.2 201.6 182.4 232.0 202.2 268.6 163.7 233.2 193.7 214.7 160.8 229.8 121.9 117.5 128.0 247.8 222.3 167.1 247.6 166.2 194.6 189.3 125.2 175.2 251.7 157.7 137.5 297.6 174.3 178.3 127.1 165.3 167.4 147.4 124.5 200.4 206.2 120.4 206.4 119.5 59.6 73.3 205.7 47.0 93.0 61.9 60.6 56.5 45.1 119.3 51.8 59.2 47.9 31.3 51.6 94.0 65.6 63.4 71.2 29.2 30.0 33.7 49.9 30.9 34.6 39.4 32.0 39.4 22.5 41.0 31.6 14.5 16.0 39.5 32.3 31.6 39.0 23.5 26.9 46.7 22.8 38.3 29.7 239.9 15.7 21.5 12.9 62.6 18.5 24.1 66.9 35.2 32.5 6.6 25.1 31.5 27.2 16.9 36.0 21.5 45.1 31.3 25.8 42.3 53.5 27.9 21.3 18.9 29.7 34.3 10.1 24.6 43.9 20.3 39.4 35.0 4.8 20.2 34.6 10.6 9.4 44.8 16.7 16.5 18.6 18.8 44.6 35.7 19.9 46.7 33.1 50.4 22.0 14.9 38.3 13.1 27.8 38.2 29.7 25.8 74.8 52.1 16.8 25.8 32.0 71.3 34.5 CSF1R "C-FMS, CD115, CSFR, FMS" ENSG00000182578 "Colony stimulating factor 1 receptor" P07333 5 150053291-150113372 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" "Immunity, Inflammatory response, Innate immunity" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Neurodegeneration, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 113.3;placenta: 103.3" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 103.2;Hofbauer cells: 340.4;Kupffer cells: 291.2;Langerhans cells: 73.4;Macrophages: 196.3;Microglial cells: 134.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "intermediate monocyte: 444.6;non-classical monocyte: 646.9" "Lineage enriched" "Detected in many" 5 "monocytes: 646.9" "Group enriched" "Detected in some" 4 "BEWO: 123.0;SK-BR-3: 47.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008970, HPA012323" Uncertain Supported "Vesicles,Plasma membrane" "Intracellular and membrane" NA NA 1600000000 "Cluster 51: Monocytes - Innate immune response" "Cluster 64: Macrophages - Immune response" "Cluster 28: BEWO - Transcription regulation" "Cluster 4: Macrophages - Innate immune response" "Vesicles, Plasma membrane" "CAB008970: , HPA012323: AB_1848977" "unprognostic (3.82e-2)" "unprognostic (1.31e-1)" "unprognostic (1.86e-3)" "unprognostic (9.83e-2)" "unprognostic (1.20e-1)" "unprognostic (7.33e-2)" "unprognostic (1.03e-1)" "unprognostic (1.45e-1)" "unprognostic (9.37e-2)" "unprognostic (1.11e-2)" "unprognostic (2.49e-1)" "unprognostic (1.65e-1)" "prognostic unfavorable (1.08e-4)" "unprognostic (3.67e-2)" "prognostic unfavorable (4.92e-4)" "unprognostic (1.72e-2)" "unprognostic (4.61e-2)" 51.3 31.0 19.6 75.1 17.1 5.6 19.3 20.2 21.4 21.6 19.3 21.9 24.3 12.1 5.8 21.0 17.2 40.6 16.6 19.8 33.8 7.1 27.5 36.6 54.4 41.4 35.5 12.7 9.9 11.8 5.7 103.3 40.1 9.1 21.5 1.5 10.1 20.8 3.2 13.4 37.3 41.9 36.6 113.3 21.0 7.0 40.6 14.3 6.0 11.8 21.7 42.6 3.8 67.6 4.5 0.2 0.0 0.0 1.9 0.4 123.0 0.2 0.2 0.0 0.0 3.8 0.0 5.9 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.2 0.1 0.1 0.0 0.0 0.1 0.1 0.1 0.2 1.1 3.0 0.0 6.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 6.1 0.1 0.0 0.0 0.0 1.9 0.6 0.0 0.0 0.2 0.2 0.0 47.8 0.0 1.9 0.0 20.7 0.0 0.8 0.2 0.1 3.3 0.0 0.3 0.1 6.6 2.6 0.0 3.0 138.4 4.0 0.6 444.6 0.6 0.3 0.2 0.4 139.0 0.2 0.3 0.2 21.6 0.2 646.9 11.1 0.5 132.7 19.6 17.1 20.2 21.4 19.8 33.8 41.4 35.5 40.1 36.6 40.6 67.6 2.0 0.0 3.8 0.0 4.3 2.8 0.0 0.0 1.2 0.0 0.5 2.3 3.1 4.3 0.0 0.0 0.0 6.2 2.8 0.0 0.0 0.0 4.8 0.0 0.1 10.5 0.0 2.5 0.4 0.0 103.2 2.2 1.5 0.2 2.5 8.3 2.9 1.5 340.4 0.0 0.5 0.3 0.0 291.2 73.4 5.4 1.8 196.3 3.6 134.9 39.4 0.0 1.0 1.5 0.3 0.1 1.7 0.0 1.0 0.0 0.0 0.1 0.7 0.5 13.1 1.2 2.0 2.2 0.2 0.4 1.3 26.4 1.3 2.2 0.2 0.0 CSGALNACT1 "ChGn, CSGalNAcT-1, FLJ11264" ENSG00000147408 "Chondroitin sulfate N-acetylgalactosaminyltransferase 1" Q8TDX6 8 19404161-19758029 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Transferase "Disease variant, Dwarfism" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "thyroid gland: 86.7" "Cell type enhanced" "Detected in many" "Astrocytes: 494.3;Excitatory neurons: 144.4;Granulosa cells: 214.1;Microglial cells: 224.9;Oligodendrocyte precursor cells: 355.9" "Cancer enhanced" "Detected in all" "prostate cancer: 22.9" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "T-reg: 62.6" "Group enriched" "Detected in all" 5 "B-cells: 44.5;granulocytes: 24.9;T-cells: 62.6" "Cell line enhanced" "Detected in many" "A549: 57.8;BJ hTERT+: 32.3;GAMG: 22.9;RPTEC TERT1: 39.6;U-2197: 36.8;U-87 MG: 26.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA068462 Approved "Golgi apparatus,Cytosol" "Intracellular and membrane" NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 89: Fibroblasts - ECM organization" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 40: Granulosa cells - Unknown function" Cytosol "Golgi apparatus" "HPA068462: " "unprognostic (8.90e-2)" "unprognostic (1.57e-2)" "unprognostic (4.66e-2)" "unprognostic (2.58e-1)" "unprognostic (6.03e-2)" "unprognostic (3.17e-3)" "unprognostic (9.78e-2)" "unprognostic (7.76e-2)" "unprognostic (1.20e-1)" "unprognostic (1.60e-2)" "unprognostic (8.22e-2)" "unprognostic (6.82e-2)" "unprognostic (1.22e-2)" "unprognostic (1.89e-1)" "unprognostic (2.38e-2)" "unprognostic (1.46e-3)" "unprognostic (1.02e-2)" 19.4 12.5 20.3 8.8 15.7 11.1 7.4 4.8 18.3 18.0 0.7 4.7 3.5 7.0 5.4 31.2 11.8 16.1 35.8 16.3 11.5 6.0 2.8 11.7 7.6 6.3 11.2 57.0 7.9 11.4 3.0 38.8 7.6 31.8 2.5 2.5 6.8 9.8 5.8 4.8 4.7 12.3 6.7 8.7 6.9 2.8 8.9 11.7 86.7 11.0 8.8 23.4 8.1 10.7 2.1 57.8 0.5 0.0 9.3 2.1 7.9 1.4 32.3 0.3 0.3 3.1 1.0 0.0 0.3 0.0 22.9 0.7 0.0 0.0 0.4 7.5 0.4 0.2 16.2 1.9 4.1 0.0 0.1 0.9 1.6 0.7 0.3 0.4 11.6 0.2 0.0 0.1 0.1 2.6 2.9 0.2 0.3 8.3 1.7 0.3 0.1 0.0 39.6 1.6 0.2 0.3 17.2 6.9 2.4 1.5 0.1 0.4 1.0 1.1 1.3 36.8 0.9 0.3 0.0 0.0 26.0 3.4 11.4 0.1 2.9 24.9 5.6 0.1 0.6 44.5 25.7 8.5 2.8 15.9 44.6 11.6 15.6 8.4 0.4 4.2 62.6 11.7 20.3 15.7 4.8 18.3 16.3 11.5 6.3 11.2 7.6 6.7 8.9 10.7 33.3 3.2 1.1 494.3 27.3 4.5 7.4 0.2 0.6 0.3 4.1 0.8 45.8 0.0 0.9 12.9 10.4 1.9 6.2 0.0 1.9 5.7 6.9 7.5 1.2 38.5 3.0 3.2 144.4 1.7 14.6 20.9 2.0 2.0 0.0 214.1 26.7 0.2 15.8 18.5 76.5 0.0 16.2 27.4 6.5 7.4 5.3 14.1 12.4 224.9 3.5 1.0 6.2 355.9 4.6 3.1 0.0 12.0 21.3 21.8 0.0 0.1 1.5 1.0 6.6 2.1 12.0 0.7 0.1 0.5 3.1 8.3 9.6 77.0 0.1 2.8 CSGALNACT2 "GALNACT-2, GALNACT2, MGC40204, PRO0082" ENSG00000169826 "Chondroitin sulfate N-acetylgalactosaminyltransferase 2" Q8N6G5 10 43138445-43185302 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 5 "bone marrow: 133.9" "Cell type enhanced" "Detected in many" "Langerhans cells: 121.6;Macrophages: 82.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031540 Approved Approved "Endoplasmic reticulum" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 30: Epithelial cell lines - Translation" "Cluster 41: Macrophages - Immune response" "Endoplasmic reticulum" "HPA031540: AB_10599943" "unprognostic (1.65e-1)" "unprognostic (2.70e-2)" "unprognostic (9.10e-2)" "unprognostic (6.41e-2)" "unprognostic (1.95e-1)" "unprognostic (8.28e-3)" "unprognostic (2.85e-3)" "unprognostic (4.95e-2)" "unprognostic (2.96e-1)" "unprognostic (3.43e-3)" "unprognostic (7.65e-2)" "unprognostic (1.90e-1)" "prognostic unfavorable (3.53e-7)" "unprognostic (2.68e-2)" "unprognostic (1.40e-1)" "unprognostic (2.47e-1)" "unprognostic (4.05e-3)" 19.7 10.6 8.8 24.1 10.8 133.9 12.9 15.1 13.3 15.1 12.6 15.1 9.2 19.5 8.4 10.5 15.5 25.4 12.8 8.5 10.8 8.8 13.9 26.8 22.5 10.7 9.7 17.0 7.8 8.0 11.6 26.4 11.1 13.4 11.6 9.8 7.9 10.9 14.6 11.0 11.5 20.8 9.4 26.5 10.1 9.2 9.9 27.9 9.9 17.2 17.4 24.0 12.1 13.5 12.6 8.2 15.1 14.4 23.0 38.5 3.7 44.7 59.8 19.3 30.0 2.9 12.7 20.8 10.8 40.6 9.2 11.4 12.6 16.8 31.3 24.9 9.3 10.8 7.9 8.6 50.0 25.3 21.8 38.6 18.1 43.1 89.3 24.3 25.0 30.7 4.6 60.1 39.9 6.5 19.3 15.1 6.5 4.2 10.7 11.9 15.0 8.8 17.1 6.6 13.6 26.8 11.6 11.9 28.8 13.0 15.7 20.5 37.3 16.5 26.2 52.3 30.4 15.4 23.2 10.9 35.1 60.8 7.9 14.7 11.9 19.4 7.3 14.2 6.4 3.0 5.5 5.7 14.4 3.0 6.4 5.4 11.2 11.3 21.8 4.1 7.1 6.9 8.8 10.8 15.1 13.3 8.5 10.8 10.7 9.7 11.1 9.4 9.9 13.5 16.3 16.0 18.7 23.8 20.5 17.7 13.3 7.0 6.2 13.1 10.7 8.5 10.9 5.7 9.6 11.0 10.4 2.1 47.8 1.7 0.0 5.9 2.1 12.0 22.0 16.8 9.0 18.5 42.5 6.9 6.1 31.4 4.6 11.3 48.1 23.5 11.4 11.9 16.4 8.4 41.1 1.6 4.1 68.6 121.6 1.4 17.1 82.6 8.8 16.9 41.5 4.1 35.0 45.2 54.5 13.7 3.1 12.4 33.8 12.7 1.5 4.4 5.8 8.5 26.3 27.7 25.3 17.8 18.3 3.6 12.1 1.5 37.4 7.2 1.6 7.0 CSK ENSG00000103653 "C-terminal Src kinase" P41240 15 74782057-74803198 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Adaptive immunity, Immunity" "Kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 169.3" "Cell type enhanced" "Detected in all" "B-cells: 130.9;dendritic cells: 99.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011203, HPA026488, HPA028425" Approved Approved Enhanced Vesicles,Cytosol No No 150000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 16: Immune cells - Immune response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 57: B-cells - Immune response" "Vesicles, Cytosol" "CAB011203: AB_259070, HPA026488: AB_1847273, HPA028425: AB_10600899" "unprognostic (1.05e-1)" "prognostic favorable (5.14e-5)" "unprognostic (2.59e-3)" "prognostic favorable (8.22e-4)" "unprognostic (4.15e-2)" "unprognostic (4.11e-2)" "unprognostic (1.87e-1)" "unprognostic (2.96e-1)" "unprognostic (2.20e-1)" "unprognostic (1.31e-1)" "unprognostic (4.12e-2)" "unprognostic (4.61e-2)" "prognostic unfavorable (1.74e-4)" "prognostic favorable (1.07e-4)" "unprognostic (1.44e-1)" "unprognostic (1.01e-1)" "unprognostic (6.29e-2)" 21.4 19.9 23.4 89.1 26.2 50.6 19.4 26.5 26.7 26.8 18.2 33.6 36.7 22.4 8.0 98.5 20.0 22.9 29.3 22.5 23.9 21.3 48.8 32.0 169.3 31.0 29.8 19.0 17.2 15.8 21.1 17.6 31.6 24.8 19.5 6.9 31.6 14.1 14.8 36.7 59.9 18.7 29.1 127.9 30.0 19.2 28.2 68.5 19.5 15.8 106.3 33.0 32.8 28.4 62.2 85.6 41.2 68.1 38.5 29.2 35.3 40.7 38.8 75.7 53.6 78.9 56.0 275.7 52.6 37.0 70.2 62.9 87.2 82.1 21.2 134.7 107.8 233.8 29.5 80.2 53.3 123.6 285.1 41.7 39.6 54.0 48.1 37.9 58.1 127.5 68.7 93.1 45.7 104.6 89.7 72.7 51.2 55.7 60.6 98.0 35.4 201.9 34.9 135.6 68.1 47.2 52.8 109.5 72.3 26.2 75.5 179.5 50.7 91.1 47.8 72.5 71.7 49.6 108.7 283.8 47.1 232.5 63.1 88.7 68.0 176.1 74.3 146.8 63.4 95.6 63.6 73.9 76.6 113.6 48.3 57.0 130.8 58.6 169.8 44.3 106.2 79.5 23.4 26.2 26.5 26.7 22.5 23.9 31.0 29.8 31.6 29.1 28.2 28.4 21.3 3.2 9.2 8.5 130.9 9.3 8.2 7.6 13.1 16.6 16.7 17.1 11.5 12.8 9.3 9.2 6.2 7.5 99.1 40.6 1.9 9.3 15.8 10.0 15.1 15.3 9.5 29.2 5.3 14.0 13.7 11.3 27.0 15.3 26.6 19.0 12.5 34.3 50.7 28.6 10.0 23.2 6.1 91.2 44.9 3.3 9.0 85.1 8.8 23.4 86.9 6.4 90.6 3.5 4.7 21.2 18.4 8.2 56.7 13.9 27.5 8.0 9.3 5.1 6.6 6.9 18.1 5.7 12.5 49.4 9.1 5.6 90.3 21.5 27.5 14.9 CSNK1A1 "CK1, CK1a, CK1alpha, CKIa, CKIalpha" ENSG00000113712 "Casein kinase 1 alpha 1" P48729 5 149492982-149551471 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Suprabasal keratinocytes: 847.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB016680, HPA051334" Uncertain Approved Cytosol NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 30: Epithelial cell lines - Translation" "Cluster 22: Epithelial cell types - Mixed function" Cytosol "CAB016680: AB_1614518, HPA051334: AB_2681446" "unprognostic (4.27e-3)" "unprognostic (5.85e-3)" "prognostic favorable (1.15e-4)" "unprognostic (7.39e-2)" "unprognostic (2.66e-1)" "unprognostic (3.14e-1)" "unprognostic (1.27e-2)" "unprognostic (5.56e-2)" "unprognostic (4.38e-1)" "unprognostic (8.31e-2)" "prognostic unfavorable (5.79e-4)" "unprognostic (5.47e-2)" "unprognostic (1.56e-1)" "unprognostic (7.92e-2)" "unprognostic (4.41e-2)" "unprognostic (6.28e-3)" "unprognostic (6.92e-2)" 77.0 67.6 49.0 67.3 53.9 210.8 97.8 60.0 52.7 67.9 61.5 83.2 56.6 73.7 60.2 142.4 56.6 79.7 87.6 48.6 55.9 50.3 68.2 69.6 60.0 61.3 56.4 53.2 55.0 99.4 48.8 71.7 56.6 88.3 68.2 57.6 71.3 69.2 104.1 121.4 63.1 82.9 57.9 60.7 73.5 45.6 57.8 81.0 76.9 59.5 81.8 94.8 82.3 66.3 154.4 106.4 151.0 144.1 143.6 191.4 185.0 189.7 176.8 146.0 153.5 194.1 187.0 71.6 221.3 183.3 140.7 153.9 101.2 292.5 184.1 124.6 78.0 96.9 96.6 87.8 143.1 163.9 148.4 158.5 313.4 148.1 269.0 163.9 184.7 137.2 102.2 116.0 140.7 104.4 152.2 66.6 71.4 167.6 247.3 129.0 96.1 98.9 112.3 248.3 123.5 110.5 151.1 193.3 200.8 135.6 194.1 134.4 164.6 168.6 83.6 118.2 197.1 117.0 149.2 100.6 169.2 95.6 216.9 106.0 72.6 66.6 47.5 68.9 51.6 50.2 58.1 49.7 80.0 39.9 61.4 55.2 61.1 63.7 67.8 47.4 76.7 94.7 49.0 53.9 60.0 52.7 48.6 55.9 61.3 56.4 56.6 57.9 57.8 66.3 169.7 147.4 176.7 137.1 101.8 684.5 583.1 270.0 187.8 135.8 257.0 158.4 63.5 90.1 298.1 115.8 64.6 171.2 135.6 126.8 92.0 167.1 95.7 195.8 193.5 191.1 129.9 146.7 108.4 184.1 223.7 159.8 124.4 285.2 117.6 114.0 216.4 108.9 136.1 151.4 115.4 141.9 154.6 167.8 311.5 87.5 104.1 183.8 152.9 119.0 156.6 156.9 108.1 168.4 198.1 197.2 113.9 111.7 105.4 368.6 120.4 102.8 276.7 109.6 157.8 190.2 216.1 181.9 88.9 272.4 847.7 350.9 133.5 177.0 115.7 485.2 CSNK1A1L MGC33182 ENSG00000180138 "Casein kinase 1 alpha 1 like" Q8N752 13 37103259-37105664 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in single" 6 "testis: 3.5" "Group enriched" "Detected in some" 6 "Early spermatids: 30.0;Late spermatids: 23.0;Spermatocytes: 16.1" "Not detected" "Not detected" "Not detected" "Not detected" "Immune cell enriched" "Detected in single" 33 "neutrophil: 7.6" "Lineage enriched" "Detected in single" 39 "granulocytes: 7.6" "Not detected" "Not detected" HPA051334 Uncertain Cytosol NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 78: Testis - Spermatogenesis" "Cluster 10: Non-specific - Unknown function" Cytosol "HPA051334: AB_2681446" "unprognostic (1.23e-2)" "unprognostic (1.59e-1)" "unprognostic (3.19e-2)" "unprognostic (3.54e-2)" "unprognostic (2.40e-2)" "unprognostic (5.40e-2)" "unprognostic (8.90e-2)" "unprognostic (3.47e-1)" "unprognostic (1.47e-3)" "unprognostic (4.50e-1)" "unprognostic (2.02e-1)" "unprognostic (2.28e-3)" "unprognostic (3.45e-1)" "unprognostic (2.38e-1)" 0.0 0.0 0.0 0.1 0.1 0.5 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 3.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.1 7.6 0.1 0.1 0.0 0.1 0.2 0.0 0.1 0.0 0.2 0.0 0.1 0.1 0.0 0.1 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.1 1.8 3.5 0.2 0.0 0.0 0.0 0.0 2.4 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.1 30.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.1 0.3 0.0 0.0 0.0 0.0 1.4 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.7 23.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.1 0.0 0.0 0.6 2.2 16.1 1.2 0.0 2.7 0.3 0.0 0.0 0.1 1.7 CSNK1D "CKID, CKIdelta, HCKID" ENSG00000141551 "Casein kinase 1 delta" P48730 17 82239023-82273731 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Biological rhythms, Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 4 "Early spermatids: 312.5;Late spermatids: 775.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB015410 Approved Approved "Nucleoplasm,Nucleoli fibrillar center" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 72: Non-specific - Transcription" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoli fibrillar center" Nucleoplasm "CAB015410: AB_831049" "unprognostic (1.07e-2)" "unprognostic (1.27e-1)" "unprognostic (2.31e-1)" "prognostic unfavorable (7.04e-4)" "unprognostic (2.38e-2)" "unprognostic (3.43e-2)" "prognostic unfavorable (2.38e-6)" "unprognostic (8.05e-2)" "unprognostic (1.09e-1)" "unprognostic (5.00e-2)" "prognostic favorable (9.62e-5)" "unprognostic (2.23e-3)" "prognostic unfavorable (8.34e-4)" "unprognostic (3.54e-1)" "unprognostic (2.52e-1)" "unprognostic (5.52e-3)" "unprognostic (4.74e-2)" 46.7 57.0 36.9 28.9 36.9 25.9 42.3 34.4 37.9 45.3 30.3 57.1 35.1 56.6 26.7 50.8 45.3 24.8 42.4 39.0 40.2 45.5 40.9 45.3 30.8 37.2 37.6 43.1 47.5 43.1 54.2 30.2 36.3 51.8 20.0 15.1 48.6 36.8 88.9 36.4 50.9 29.0 36.3 56.3 49.3 60.7 42.6 34.0 44.7 38.7 22.8 49.0 37.0 32.9 60.3 70.9 39.5 54.7 50.8 53.9 77.7 85.1 54.4 61.0 56.8 58.6 49.4 55.0 66.3 62.5 64.8 57.1 37.4 88.3 48.9 47.0 90.5 68.5 53.4 63.7 146.9 56.9 50.4 81.9 61.5 41.6 61.3 76.0 90.0 39.5 78.5 28.4 58.5 70.6 73.7 59.3 42.2 71.3 108.6 62.6 48.7 49.7 64.8 93.4 48.5 87.4 100.4 85.5 97.7 54.3 61.5 73.0 95.6 86.9 77.3 76.2 67.0 61.0 32.1 58.4 69.5 48.1 64.7 8.8 20.8 27.4 12.3 21.3 11.8 11.1 9.6 12.1 20.1 9.0 8.1 8.7 50.4 15.3 20.3 9.6 9.2 15.4 36.9 36.9 34.4 37.9 39.0 40.2 37.2 37.6 36.3 36.3 42.6 32.9 65.8 48.1 54.3 36.6 81.1 56.6 116.0 58.3 52.9 46.5 59.8 51.2 19.7 31.5 65.7 42.3 27.1 61.8 101.0 105.2 33.2 71.6 312.5 69.6 54.0 54.2 46.2 32.4 24.4 69.6 95.2 42.8 87.1 93.2 60.1 45.3 42.5 33.6 65.3 95.9 21.2 62.8 67.1 51.5 83.8 775.6 30.1 75.7 28.4 24.4 65.8 28.7 79.3 24.6 21.2 87.7 83.2 40.3 80.9 90.8 94.3 43.8 66.6 54.4 39.5 78.6 57.5 55.1 29.6 44.2 48.3 126.6 87.6 46.7 56.7 118.6 CSNK1E "CKIE, CKIepsilon, HCKIE" ENSG00000213923 "Casein kinase 1 epsilon" P49674 22 38290691-38318084 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Biological rhythms" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Urothelial cells: 280.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "plasmacytoid DC: 15.9" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "CAB009626, HPA026288" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 57: Non-specific - Angiogenesis" "Cluster 17: WM-115 - Nervous system development" "Cluster 22: Epithelial cell types - Mixed function" "Nucleoplasm, Cytosol" "CAB009626: AB_2084517, HPA026288: AB_1847276" "unprognostic (2.32e-1)" "unprognostic (8.41e-2)" "unprognostic (5.14e-2)" "unprognostic (5.01e-3)" "unprognostic (1.95e-2)" "unprognostic (4.50e-3)" "prognostic unfavorable (8.20e-5)" "unprognostic (2.08e-3)" "unprognostic (3.69e-1)" "unprognostic (1.22e-1)" "unprognostic (9.63e-2)" "unprognostic (4.16e-3)" "prognostic unfavorable (4.67e-6)" "unprognostic (1.91e-1)" "unprognostic (1.66e-1)" "unprognostic (2.58e-1)" "unprognostic (3.25e-3)" 87.1 52.8 81.1 41.2 82.6 51.6 88.3 80.8 95.1 93.6 66.0 73.0 41.4 82.7 52.5 69.0 83.3 48.7 80.9 82.9 73.7 70.2 37.4 92.2 40.3 78.9 78.6 109.5 64.9 74.1 85.1 71.2 79.5 80.3 35.5 47.3 71.6 44.9 60.5 94.8 50.9 45.3 70.2 63.6 58.0 29.5 83.2 33.3 64.4 47.2 37.8 65.7 88.4 93.9 101.5 57.4 121.6 114.7 61.5 88.3 92.1 126.9 168.6 116.7 114.3 63.9 76.7 74.2 53.0 120.7 70.7 77.9 96.1 177.9 79.2 123.0 215.2 23.9 181.2 47.4 123.7 48.3 61.9 90.2 143.8 171.7 220.3 141.0 121.1 60.6 50.9 155.0 110.8 68.4 71.1 60.9 87.2 67.3 69.1 130.8 90.1 123.4 99.0 92.4 181.6 69.3 102.9 109.3 124.7 68.0 59.5 73.0 134.3 94.0 111.3 58.7 102.1 61.2 105.2 104.5 151.0 56.9 176.3 4.8 1.6 3.6 3.0 0.8 3.8 2.1 3.4 3.0 1.8 3.1 1.9 2.5 3.8 5.7 0.5 15.9 1.6 1.2 81.1 82.6 80.8 95.1 82.9 73.7 78.9 78.6 79.5 70.2 83.2 93.9 73.4 38.5 21.7 0.0 32.3 78.6 158.8 89.1 68.9 132.6 53.7 42.4 49.8 34.3 73.9 23.9 60.5 35.2 42.3 28.4 7.9 30.8 46.0 94.3 72.5 76.4 62.8 12.6 0.0 41.8 49.2 60.8 39.8 126.5 3.8 46.6 45.0 21.3 23.1 72.3 0.0 46.0 46.8 17.6 54.1 69.1 85.4 21.8 60.5 0.0 13.3 117.9 28.8 0.0 0.0 57.5 33.1 66.2 83.5 160.5 9.0 6.5 62.8 60.7 72.3 85.7 98.0 8.0 20.0 50.3 104.7 125.5 26.0 34.9 37.6 280.8 CSNK1G1 CK1gamma1 ENSG00000169118 "Casein kinase 1 gamma 1" Q9HCP0 15 64165525-64356173 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 35.0" "Cell type enhanced" "Detected in all" "Early spermatids: 130.6;Late spermatids: 261.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA018209 Supported Cytosol NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 25: Spermatids - Spermatogenesis" Cytosol "HPA018209: AB_1847278" "unprognostic (9.10e-2)" "unprognostic (8.09e-2)" "unprognostic (1.20e-1)" "unprognostic (2.65e-2)" "unprognostic (1.20e-1)" "unprognostic (1.64e-1)" "unprognostic (7.90e-3)" "unprognostic (3.07e-1)" "unprognostic (1.61e-2)" "unprognostic (2.02e-1)" "unprognostic (8.63e-2)" "unprognostic (3.75e-2)" "unprognostic (7.51e-2)" "unprognostic (8.16e-3)" "unprognostic (1.31e-1)" "unprognostic (2.59e-2)" "unprognostic (2.41e-1)" 4.0 3.4 6.1 6.1 6.9 9.0 6.0 6.4 7.7 5.4 6.3 5.0 3.9 4.5 6.7 7.9 7.3 4.0 2.9 10.4 7.1 5.3 2.9 5.3 5.9 2.8 4.3 5.2 4.1 6.3 4.7 4.9 2.6 3.7 5.4 14.5 3.6 4.4 4.1 6.6 3.8 5.3 3.6 5.9 4.3 35.0 6.8 9.3 7.9 3.3 6.8 5.5 4.6 4.9 6.8 14.2 10.0 13.2 8.3 11.4 8.9 8.3 8.5 13.8 12.5 11.5 13.2 10.8 4.3 13.3 14.2 15.4 26.7 16.5 16.1 20.6 6.8 10.1 11.2 8.0 9.8 18.9 11.4 10.3 21.7 14.0 20.0 11.9 15.4 10.6 12.3 10.4 12.8 9.4 9.7 5.8 9.4 8.9 7.4 16.1 12.5 8.6 11.2 26.8 16.2 9.9 11.1 6.5 9.5 16.4 11.4 7.4 16.8 12.6 14.9 9.8 10.5 12.3 26.0 8.8 11.6 13.5 7.9 0.4 1.9 3.1 2.8 2.8 4.0 1.8 2.5 2.1 1.4 1.8 2.4 2.3 4.5 2.8 2.3 2.1 2.2 1.3 6.1 6.9 6.4 7.7 10.4 7.1 2.8 4.3 2.6 3.6 6.8 4.9 10.9 28.9 11.3 35.6 12.9 11.6 10.5 13.7 19.9 47.1 11.6 7.9 7.3 11.5 12.7 5.5 68.8 6.9 12.6 12.2 1.9 9.6 130.6 37.4 17.9 12.2 22.8 7.8 69.4 7.0 9.0 10.3 15.3 24.6 3.8 15.8 10.4 4.4 10.4 10.1 49.8 10.5 6.1 9.7 10.0 261.1 6.2 14.1 7.2 40.3 13.5 7.9 5.2 40.2 41.3 12.0 7.5 10.1 14.3 11.1 8.2 9.7 23.3 29.3 6.6 14.4 11.8 31.9 19.8 26.7 15.6 4.1 13.2 7.9 10.4 13.2 CSNK1G2 CK1g2 ENSG00000133275 "Casein kinase 1 gamma 2" P78368 19 1941172-1981338 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 4 "Early spermatids: 254.8;Late spermatids: 613.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034868, HPA056572" Uncertain Approved Vesicles NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 25: Spermatids - Spermatogenesis" Vesicles "HPA034868: AB_10671235, HPA056572: AB_2683178" "unprognostic (2.00e-1)" "unprognostic (2.15e-1)" "unprognostic (1.83e-1)" "unprognostic (2.42e-3)" "unprognostic (6.51e-3)" "unprognostic (2.27e-3)" "unprognostic (1.14e-3)" "unprognostic (2.00e-1)" "unprognostic (9.42e-2)" "unprognostic (5.78e-2)" "unprognostic (4.83e-3)" "unprognostic (4.09e-3)" "unprognostic (7.95e-2)" "unprognostic (4.65e-3)" "unprognostic (5.09e-1)" "unprognostic (2.01e-1)" "unprognostic (1.63e-2)" 37.1 52.7 19.3 40.5 17.9 47.3 38.3 22.8 28.1 35.1 18.3 35.0 29.5 34.5 6.5 50.6 35.7 20.6 33.8 21.6 16.6 42.6 41.6 53.5 41.8 20.8 19.2 39.5 39.8 13.3 51.5 17.7 18.1 41.3 8.7 9.8 38.1 14.0 39.4 45.1 46.9 10.3 12.8 69.2 35.5 99.9 18.3 23.5 35.8 12.3 18.7 32.3 37.8 18.1 71.2 37.3 51.0 80.1 17.5 32.6 42.7 43.1 28.0 32.0 39.1 31.0 37.8 44.3 35.2 27.6 17.8 50.1 27.6 52.5 14.0 40.5 60.4 31.2 65.0 52.9 28.2 50.7 76.3 32.5 33.8 33.4 21.3 24.7 38.4 54.2 67.1 146.5 21.4 41.3 101.0 66.8 92.7 19.7 41.8 86.8 32.3 72.7 24.3 73.2 81.9 67.4 32.2 52.7 48.2 18.8 33.6 81.8 46.6 40.2 31.5 85.3 50.6 94.8 54.5 55.5 40.7 47.6 42.8 2.8 3.6 4.7 4.2 5.8 3.0 3.4 3.1 3.6 3.6 3.3 2.4 3.4 10.0 3.5 14.4 5.4 2.4 2.4 19.3 17.9 22.8 28.1 21.6 16.6 20.8 19.2 18.1 12.8 18.3 18.1 37.5 16.0 17.9 10.1 36.5 21.9 17.8 14.9 10.8 43.6 28.9 26.8 14.2 10.0 14.9 11.0 41.7 12.2 91.7 36.9 9.8 17.1 254.8 37.7 32.5 24.7 30.5 12.6 10.8 29.5 18.9 21.6 31.1 32.4 29.9 41.8 16.8 16.4 14.9 25.2 9.8 26.6 6.1 21.9 30.3 613.6 20.5 32.3 14.2 14.0 16.4 21.6 41.2 5.5 6.2 30.1 24.0 18.8 38.2 28.8 15.0 14.6 22.8 39.3 13.1 26.4 23.0 16.0 13.2 19.0 25.3 18.2 46.2 51.7 24.8 32.8 CSNK1G3 ENSG00000151292 "Casein kinase 1 gamma 3" Q9Y6M4 5 123512099-123617045 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027010 Approved NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 9: Intestine - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 44: Endometrium - Transcription" "HPA027010: AB_10602803" "unprognostic (1.28e-1)" "unprognostic (1.88e-1)" "prognostic favorable (9.90e-5)" "unprognostic (1.60e-2)" "unprognostic (1.23e-1)" "unprognostic (3.07e-1)" "unprognostic (3.12e-3)" "unprognostic (1.68e-1)" "unprognostic (1.06e-1)" "unprognostic (1.18e-3)" "unprognostic (9.92e-3)" "unprognostic (4.92e-1)" "unprognostic (1.05e-2)" "unprognostic (3.44e-1)" "unprognostic (2.52e-1)" "unprognostic (1.97e-3)" "unprognostic (4.38e-1)" 13.5 12.0 8.1 13.6 9.5 11.6 15.2 13.5 9.7 12.2 6.5 21.9 21.4 15.7 10.5 16.3 12.6 15.2 10.1 9.4 9.9 14.2 25.2 13.6 14.4 6.9 7.9 15.0 9.9 15.1 6.4 14.6 8.3 10.9 24.1 7.6 9.1 9.2 5.7 9.4 23.1 16.3 7.3 13.0 16.6 15.3 9.7 14.4 14.2 8.0 16.3 20.1 10.1 7.7 28.3 26.7 39.2 37.4 39.0 43.3 19.4 29.9 35.7 32.4 48.2 24.0 44.0 0.0 37.9 36.2 37.7 20.1 31.7 59.2 55.6 42.7 21.8 19.9 29.8 25.6 34.7 10.5 19.7 37.1 37.7 36.7 68.8 38.5 35.9 13.7 11.3 22.2 27.7 19.6 14.2 13.0 22.1 22.2 18.2 15.8 41.4 27.0 24.3 30.6 33.9 24.5 33.3 21.8 50.1 32.4 28.6 29.1 33.2 47.5 35.6 29.1 33.5 24.7 29.0 25.1 28.4 29.8 31.4 12.4 5.7 2.5 6.3 5.4 8.6 12.4 5.3 5.6 5.2 11.9 5.4 5.8 4.4 13.4 6.1 4.5 7.3 4.9 8.1 9.5 13.5 9.7 9.4 9.9 6.9 7.9 8.3 7.3 9.7 7.7 42.4 22.4 14.1 40.5 54.9 20.6 25.6 19.6 33.0 30.1 25.3 22.2 20.6 7.2 18.0 11.0 8.4 8.6 38.3 35.2 21.5 23.7 10.9 26.3 29.9 30.7 32.8 5.9 75.4 25.0 15.2 31.8 25.5 31.8 5.7 29.9 29.3 23.4 9.6 90.9 74.8 27.2 22.4 17.3 18.0 15.8 19.9 20.5 16.0 65.6 32.0 26.2 39.1 97.0 54.5 30.5 42.8 19.5 38.5 28.5 33.9 22.2 18.8 3.3 0.0 28.2 27.8 26.6 53.7 24.8 18.8 6.7 32.7 21.7 23.9 43.2 CSNK2A1 "Cka1, Cka2" ENSG00000101266 "Casein kinase 2 alpha 1" P68400 20 472498-543835 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Biological rhythms, Cell cycle, Transcription, Transcription regulation, Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB020680, HPA059206, HPA061698, CAB069395" Supported Supported Nucleoplasm NA NA "Cluster 34: Basophils - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 52: Non-specific - Transcription" Nucleoplasm "CAB020680: , CAB069395: AB_1611912, HPA059206: AB_2683948, HPA061698: AB_2732667" "unprognostic (1.19e-1)" "unprognostic (1.44e-1)" "unprognostic (5.44e-2)" "unprognostic (8.28e-3)" "unprognostic (3.62e-2)" "unprognostic (2.04e-2)" "prognostic unfavorable (4.11e-6)" "unprognostic (4.08e-2)" "unprognostic (3.89e-1)" "unprognostic (6.88e-2)" "unprognostic (1.94e-2)" "unprognostic (1.16e-1)" "unprognostic (8.58e-2)" "unprognostic (1.50e-1)" "unprognostic (4.47e-1)" "unprognostic (9.53e-2)" "unprognostic (7.37e-2)" 36.1 32.6 20.9 38.6 23.2 34.0 35.9 28.2 29.6 36.5 29.3 48.3 39.1 35.8 26.6 50.0 39.9 31.3 54.0 25.7 21.0 41.0 31.8 31.6 41.2 20.6 21.1 41.5 46.9 59.1 21.2 42.4 21.1 35.8 40.7 32.9 41.1 37.7 110.5 34.2 40.5 39.1 18.8 30.2 49.5 65.2 22.3 51.6 39.6 86.4 46.6 47.4 28.5 27.3 209.5 170.4 152.9 96.0 61.1 103.8 103.5 117.9 116.1 125.8 139.5 178.5 120.0 179.1 74.2 90.1 179.1 147.8 162.1 167.4 187.2 62.6 57.7 247.3 44.7 177.7 102.5 228.1 51.3 99.5 173.3 105.8 316.0 122.2 139.5 146.4 248.9 112.6 123.8 64.2 262.0 73.7 227.4 173.4 97.6 149.8 140.5 140.9 112.9 128.5 163.9 132.3 97.2 184.0 174.8 120.7 120.4 83.9 142.7 136.0 118.4 90.0 178.5 120.6 311.8 174.1 65.8 119.5 138.6 40.5 23.8 28.7 18.2 32.3 22.4 23.0 18.0 17.6 31.5 22.5 17.9 17.4 14.9 25.1 33.5 25.7 20.4 20.8 20.9 23.2 28.2 29.6 25.7 21.0 20.6 21.1 21.1 18.8 22.3 27.3 50.7 64.1 84.6 51.9 46.1 41.0 40.0 43.8 45.5 49.4 42.1 36.1 59.4 41.5 75.8 44.1 31.3 42.2 50.5 43.5 41.1 68.5 135.5 67.6 77.0 44.5 35.2 59.3 65.6 50.6 54.4 46.3 40.2 75.7 63.8 108.6 27.1 31.1 33.2 60.6 69.3 41.8 46.8 39.2 30.3 140.0 41.0 45.3 14.2 51.5 61.7 38.6 37.0 73.9 73.6 66.6 34.4 36.9 49.6 57.2 43.2 68.8 65.5 27.8 52.6 43.6 56.8 94.2 68.7 52.3 50.2 61.4 38.9 81.2 40.6 59.4 CSNK2A2 "CK2alpha', CSNK2A1" ENSG00000070770 "Casein kinase 2 alpha 2" P19784 16 58157907-58198106 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle, Transcription, Transcription regulation, Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 112.7" "Group enriched" "Detected in all" 5 "Early spermatids: 227.4;Late spermatids: 281.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA 92000 "Cluster 46: Basophils - DNA binding" "Cluster 27: Brain & Skin - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 34: Spermatids - Unknown function" "unprognostic (9.49e-2)" "unprognostic (1.87e-1)" "unprognostic (5.45e-2)" "unprognostic (1.23e-1)" "unprognostic (2.08e-1)" "prognostic unfavorable (1.40e-5)" "prognostic unfavorable (1.80e-4)" "unprognostic (6.84e-3)" "unprognostic (2.93e-3)" "unprognostic (2.40e-1)" "unprognostic (3.03e-2)" "unprognostic (1.63e-1)" "unprognostic (5.89e-2)" "unprognostic (2.06e-3)" "unprognostic (7.07e-2)" "unprognostic (3.23e-1)" "unprognostic (3.14e-2)" 21.0 14.1 19.3 9.0 20.2 6.4 19.0 18.9 22.1 23.0 23.7 32.1 10.0 21.0 29.0 15.7 20.3 14.1 21.2 20.0 19.7 17.3 15.9 16.2 14.2 19.1 20.4 32.4 34.2 23.9 15.7 15.5 19.2 15.5 12.4 13.5 17.0 16.7 41.1 64.8 14.2 21.9 19.8 12.6 27.9 112.7 20.3 18.3 18.0 26.8 17.3 24.2 19.6 19.9 28.1 35.3 24.5 19.1 46.2 62.5 27.6 24.7 41.8 47.7 30.7 64.0 23.2 44.2 38.8 29.6 18.9 29.2 41.6 37.2 53.4 16.9 28.3 23.4 18.0 56.1 66.5 32.6 20.5 66.9 88.9 33.8 65.9 62.0 45.4 43.6 53.4 15.1 31.0 15.8 41.2 21.9 23.4 16.6 45.7 48.4 38.7 25.7 33.1 28.7 20.5 18.4 39.7 20.3 63.6 41.9 13.9 24.6 33.6 27.8 33.7 23.3 25.7 36.2 30.2 63.2 24.3 21.8 24.4 1.1 0.2 0.3 0.7 0.1 0.4 0.6 1.1 0.4 0.2 0.6 1.8 1.3 0.0 0.7 0.1 1.9 0.0 0.1 19.3 20.2 18.9 22.1 20.0 19.7 19.1 20.4 19.2 19.8 20.3 19.9 30.6 12.8 22.5 19.2 16.7 29.6 10.9 13.0 8.6 24.0 19.3 19.9 24.4 12.8 7.6 9.2 4.2 15.9 28.3 16.4 7.9 14.5 227.4 24.7 37.8 25.8 16.8 10.3 27.7 17.2 26.1 17.7 8.6 29.5 8.2 37.0 19.6 17.0 16.9 18.5 19.1 11.9 4.1 25.5 23.0 281.0 14.3 23.1 12.4 20.6 14.2 25.3 18.6 20.6 26.1 25.0 11.5 19.5 9.2 18.1 16.0 16.3 13.4 21.7 13.1 29.2 23.2 48.1 36.8 12.6 29.0 24.5 20.3 35.6 17.5 23.0 CSNK2A3 CSNK2A1P ENSG00000254598 "Casein kinase 2 alpha 3" Q8NEV1 11 11351942-11353250 "Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" Proto-oncogene "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in single" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 12.4;Cholangiocytes: 4.3;Smooth muscle cells: 6.9" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A-431: 2.1;SK-BR-3: 1.3" "HPA059206, HPA061698" Uncertain Approved Nucleoplasm NA NA "Cluster 59: Non-specific - Translation" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "HPA059206: AB_2683948, HPA061698: AB_2732667" "unprognostic (3.10e-2)" "unprognostic (3.39e-1)" "unprognostic (4.65e-2)" "unprognostic (1.55e-3)" "unprognostic (1.82e-2)" "unprognostic (1.60e-1)" "unprognostic (6.25e-4)" "unprognostic (4.36e-2)" "unprognostic (5.42e-2)" "unprognostic (1.88e-1)" "unprognostic (5.46e-3)" "unprognostic (1.07e-1)" "unprognostic (1.50e-1)" "unprognostic (1.31e-1)" "unprognostic (1.32e-1)" "unprognostic (1.42e-1)" "unprognostic (3.38e-2)" 0.5 0.5 0.7 0.2 0.1 0.0 0.5 0.4 0.6 0.4 0.0 0.5 0.3 0.6 0.0 0.7 0.4 0.0 0.8 0.9 0.0 0.4 0.3 0.6 0.0 0.0 0.0 0.5 0.5 0.0 0.3 0.2 0.0 0.3 0.0 0.1 0.6 0.0 1.8 0.7 0.4 0.2 0.0 0.2 0.5 0.9 0.1 0.0 0.5 0.0 0.0 0.4 0.5 0.0 2.1 0.4 0.1 0.6 0.0 0.0 0.3 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.6 0.7 0.4 0.3 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.1 0.2 0.1 0.0 0.2 0.0 0.0 0.3 0.2 0.3 0.2 0.2 0.5 0.3 0.6 0.1 0.9 0.4 0.1 0.3 0.2 0.3 0.1 0.5 0.6 1.3 0.3 0.0 0.4 0.1 0.3 0.3 0.4 0.1 0.2 0.2 0.3 0.3 0.9 0.1 1.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.7 0.1 0.4 0.6 0.9 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.2 3.2 0.5 0.0 0.5 1.8 1.0 0.7 0.0 1.2 0.6 0.9 12.4 4.3 1.0 3.7 0.0 0.7 0.5 0.4 0.0 0.7 2.5 0.1 0.3 2.0 1.2 0.0 0.0 0.8 0.5 0.9 0.0 0.4 1.3 0.6 1.8 0.3 0.3 3.3 0.0 0.3 0.0 1.6 0.8 1.9 0.6 0.2 0.0 0.0 0.6 0.9 1.0 0.0 0.0 0.5 1.2 0.0 0.1 1.2 0.6 0.7 0.9 0.5 0.0 2.3 6.9 0.9 0.9 0.0 1.0 1.0 0.6 1.1 0.6 0.6 DAPK1 "DAPK, ROCO3" ENSG00000196730 "Death associated protein kinase 1" P53355 9 87497228-87708634 "Cancer-related genes, Enzymes, Human disease related genes, Metabolic proteins, Predicted membrane proteins" "Apoptosis, Translation regulation" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 139.1;Excitatory neurons: 120.2;Inhibitory neurons: 155.9;Kupffer cells: 85.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "classical monocyte: 6.7;eosinophil: 8.7;intermediate monocyte: 14.0;myeloid DC: 4.8;non-classical monocyte: 15.2;plasmacytoid DC: 6.2" "Group enriched" "Detected in many" 56 "dendritic cells: 6.2;granulocytes: 8.7;monocytes: 15.2" "Cell line enhanced" "Detected in many" "HMC-1: 97.6;HUVEC TERT2: 56.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB037302, HPA040472, HPA048436" Approved Approved Centrosome NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 29: Non-specific - Vesicular transport" "Cluster 3: HMC-1 - Innate immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Centrosome "CAB037302: AB_1078622, HPA040472: AB_2677001, HPA048436: AB_2680390" "unprognostic (2.55e-1)" "unprognostic (1.47e-1)" "prognostic unfavorable (2.48e-5)" "unprognostic (2.77e-1)" "unprognostic (1.74e-1)" "unprognostic (3.47e-2)" "unprognostic (1.74e-1)" "unprognostic (1.75e-1)" "unprognostic (1.88e-2)" "unprognostic (5.77e-3)" "unprognostic (2.19e-2)" "unprognostic (2.77e-3)" "unprognostic (8.31e-3)" "unprognostic (8.76e-2)" "unprognostic (2.40e-1)" "unprognostic (1.68e-1)" "unprognostic (1.09e-3)" 22.9 5.9 12.1 11.8 16.4 5.4 5.9 2.2 20.5 9.6 12.6 27.1 10.1 7.9 18.8 5.5 15.2 28.0 5.2 22.8 7.6 22.0 27.6 37.5 12.5 7.6 7.6 46.0 29.2 6.7 23.4 27.3 13.8 5.2 9.2 11.5 13.7 8.5 1.8 5.0 14.4 9.4 7.8 22.8 19.5 8.1 8.6 41.8 9.8 2.3 6.8 14.5 3.8 7.5 0.0 47.5 22.5 15.8 0.7 0.3 35.4 3.1 4.4 18.3 20.4 6.8 0.3 0.4 4.7 1.0 0.2 43.9 13.9 1.0 7.9 0.4 11.4 23.4 6.6 23.7 19.5 0.0 97.6 1.4 7.5 3.5 1.4 28.5 56.3 6.5 17.8 9.6 15.4 1.5 7.0 0.0 25.4 44.4 0.0 2.0 19.8 0.1 50.6 47.6 10.2 11.3 0.0 4.6 20.1 32.7 0.0 15.2 0.4 0.1 0.3 0.1 0.1 36.9 8.1 0.0 0.2 6.4 3.0 1.7 6.7 8.7 0.0 14.0 0.0 0.1 0.0 0.0 4.8 0.0 0.0 0.1 2.0 0.1 15.2 6.2 0.0 3.0 12.1 16.4 2.2 20.5 22.8 7.6 7.6 7.6 13.8 7.8 8.6 7.5 8.8 51.3 72.2 139.1 2.7 3.6 0.8 1.2 0.6 19.4 1.3 2.3 2.4 31.5 24.3 22.0 2.1 6.8 9.5 1.1 1.9 33.8 1.8 30.2 7.9 17.3 0.0 12.8 120.2 23.0 19.0 12.3 26.5 58.6 24.1 22.1 68.9 20.8 22.7 18.5 155.9 9.3 0.0 85.7 18.3 3.1 14.9 57.1 12.4 18.7 41.2 14.6 2.1 6.6 4.7 35.8 1.9 13.5 6.2 3.2 9.6 7.0 10.2 2.9 0.0 1.5 3.9 3.4 7.2 1.6 3.1 14.2 2.8 3.4 3.7 14.9 DAPK2 "DRP-1, MGC119312" ENSG00000035664 "Death associated protein kinase 2" Q9UIK4 15 63907036-64072033 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Apoptosis "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 50.2;thyroid gland: 41.9" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 86.6;Late spermatids: 112.5;Oligodendrocytes: 99.9;Proximal enterocytes: 64.0" "Cancer enriched" "Detected in many" 15 "thyroid cancer: 30.3" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 14 "basophil: 94.3;eosinophil: 213.0;neutrophil: 65.9" "Lineage enriched" "Detected in many" 25 "granulocytes: 213.0" "Cell line enhanced" "Detected in many" "ASC diff: 10.6;HaCaT: 9.2;HMC-1: 18.3;MCF7: 9.7" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA071581 Supported "Golgi apparatus,Vesicles" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 3: HMC-1 - Innate immune response" "Cluster 31: Spermatids - Spermatogenesis" "Golgi apparatus, Vesicles" "HPA071581: AB_2686421" "unprognostic (3.20e-2)" "unprognostic (4.07e-2)" "unprognostic (4.23e-2)" "unprognostic (1.95e-3)" "unprognostic (2.88e-2)" "unprognostic (1.30e-2)" "unprognostic (2.32e-1)" "prognostic favorable (5.63e-4)" "unprognostic (1.04e-1)" "unprognostic (3.18e-1)" "unprognostic (9.21e-2)" "unprognostic (8.51e-2)" "unprognostic (4.77e-7)" "unprognostic (5.98e-2)" "unprognostic (1.45e-1)" "unprognostic (3.20e-3)" "unprognostic (9.07e-2)" 12.5 2.2 5.9 2.7 7.6 15.9 8.8 5.9 8.1 6.7 4.3 9.8 20.6 1.6 0.2 3.3 1.7 1.5 28.0 5.5 6.7 4.5 2.0 20.0 3.1 6.2 6.8 0.9 2.7 0.9 1.6 0.4 6.6 5.1 6.6 0.4 7.5 3.6 50.2 8.1 21.3 1.7 6.0 7.8 9.9 3.1 6.6 1.5 41.9 19.6 2.6 2.4 9.5 9.5 3.1 2.3 6.1 1.5 10.6 0.5 0.0 2.1 6.7 1.1 1.2 1.0 1.6 0.2 0.7 6.7 3.7 9.2 3.8 0.1 0.6 0.2 0.2 1.3 4.5 0.1 0.1 0.1 18.3 1.1 7.9 0.4 0.2 7.0 0.7 0.1 0.4 0.1 0.7 9.7 0.0 0.4 0.7 3.1 2.2 2.9 0.0 0.3 0.0 3.2 0.4 0.3 0.4 1.2 0.0 1.5 5.2 0.4 0.4 0.9 1.0 1.4 1.8 0.6 0.2 0.0 0.0 3.0 0.3 94.3 0.2 213.0 2.1 0.1 0.9 1.3 0.6 2.2 0.2 0.4 0.0 1.4 65.9 2.7 0.1 8.6 0.1 1.3 5.9 7.6 5.9 8.1 5.5 6.7 6.2 6.8 6.6 6.0 6.6 9.5 24.9 86.6 22.3 5.2 4.8 11.6 7.0 8.7 0.6 0.1 9.4 7.4 46.2 1.5 14.6 0.0 0.0 0.1 22.6 45.2 1.9 9.1 25.3 3.0 1.6 6.4 8.4 0.8 15.9 35.6 0.2 8.7 16.3 7.8 15.2 1.3 5.7 1.3 0.4 5.0 2.1 17.0 6.1 1.3 0.8 112.5 3.1 3.2 0.0 15.0 0.3 2.1 2.1 11.1 99.9 9.4 30.6 5.7 0.4 12.0 64.0 0.3 2.8 0.3 13.1 7.6 4.5 2.6 4.9 0.5 4.1 0.1 14.9 1.9 19.6 14.0 DAPK3 "ZIP, ZIPK" ENSG00000167657 "Death associated protein kinase 3" O43293 19 3958453-3971123 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Transcription, Transcription regulation, Translation regulation" "Activator, Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase" "Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA028569 Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 1: Pancreatic cells - Digestion" Cytosol Nucleoplasm "HPA028569: AB_10794319" "unprognostic (5.72e-2)" "unprognostic (3.28e-2)" "unprognostic (3.34e-3)" "prognostic favorable (2.01e-5)" "unprognostic (1.83e-1)" "unprognostic (2.37e-1)" "unprognostic (7.72e-3)" "unprognostic (2.16e-1)" "unprognostic (2.46e-2)" "unprognostic (4.95e-2)" "unprognostic (1.84e-3)" "unprognostic (7.64e-2)" "prognostic unfavorable (6.49e-4)" "unprognostic (9.92e-2)" "unprognostic (1.41e-1)" "unprognostic (5.48e-2)" "unprognostic (2.14e-1)" 49.9 25.4 15.0 29.0 15.2 18.9 47.2 14.3 27.9 58.3 18.9 92.2 30.9 85.0 8.2 37.0 55.4 36.0 106.2 16.8 13.9 27.6 30.4 72.5 21.2 16.2 15.4 48.4 36.4 19.0 38.5 31.9 18.8 53.3 11.0 9.0 41.3 39.3 113.6 51.2 44.4 36.6 11.9 29.6 61.4 42.6 17.4 15.4 31.0 21.1 11.3 59.5 45.3 17.3 79.2 61.1 37.5 47.6 27.5 30.9 57.8 106.0 84.5 84.7 55.5 113.4 23.3 43.4 50.8 93.8 59.6 61.7 36.9 60.3 30.7 64.0 61.2 17.5 76.7 65.9 87.2 42.7 63.1 70.6 73.6 77.0 44.0 50.8 71.2 29.2 56.3 73.2 52.5 51.0 42.4 31.9 58.5 31.8 48.6 52.5 55.3 40.5 51.0 60.9 59.1 41.1 71.4 84.9 61.1 43.8 61.4 33.1 134.8 108.3 49.3 98.1 134.5 81.1 72.4 50.7 86.3 44.0 59.0 32.5 18.0 32.5 23.0 20.3 16.7 15.9 17.8 21.6 16.2 16.6 13.1 12.9 29.8 24.3 14.3 18.6 23.6 14.6 15.0 15.2 14.3 27.9 16.8 13.9 16.2 15.4 18.8 11.9 17.4 17.3 24.1 25.6 10.5 6.5 17.0 100.7 99.7 84.1 27.9 15.2 23.9 15.6 29.2 24.3 35.0 11.0 2.1 50.5 14.5 69.2 17.6 90.3 40.3 27.9 28.2 38.3 27.4 7.0 9.6 88.2 79.1 27.8 40.8 37.5 20.3 24.8 21.4 7.9 22.9 11.8 7.1 48.2 48.8 13.6 22.8 23.6 22.7 16.6 37.4 8.4 25.7 12.8 30.9 6.0 6.7 117.7 49.9 22.6 13.3 46.1 59.6 14.3 18.8 10.7 32.9 19.9 53.0 34.6 15.7 24.4 71.7 93.2 15.1 26.2 29.7 46.3 DBT "BCKAD-E2, BCKDH-E2, BCOADC-E2" ENSG00000137992 "Dihydrolipoamide branched chain transacylase E2" P11182 1 100186919-100249834 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Acyltransferase, Transferase" "Disease variant, Maple syrup urine disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 65.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026481, HPA026485, HPA026533" Enhanced Supported Mitochondria NA NA "Cluster 40: NK-cells - Unknown function" "Cluster 81: Kidney & Liver - Metabolism" "Cluster 6: T47d - Mammary gland" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "HPA026481: AB_1847504, HPA026485: AB_1847505, HPA026533: AB_1847506" "unprognostic (1.23e-1)" "unprognostic (1.23e-1)" "unprognostic (3.67e-2)" "unprognostic (5.29e-2)" "unprognostic (1.92e-2)" "unprognostic (1.63e-1)" "unprognostic (3.88e-2)" "unprognostic (1.65e-2)" "unprognostic (6.01e-2)" "unprognostic (1.21e-1)" "unprognostic (2.37e-2)" "unprognostic (2.90e-1)" "prognostic favorable (8.79e-12)" "unprognostic (1.63e-1)" "unprognostic (3.77e-1)" "unprognostic (9.67e-2)" "unprognostic (9.92e-2)" 11.1 13.6 4.4 5.9 5.2 4.6 11.8 4.3 4.9 11.3 3.7 9.2 8.0 8.2 6.0 12.8 11.1 6.3 25.9 4.2 5.0 30.3 43.4 7.4 7.5 5.6 4.6 11.1 15.4 19.4 2.3 10.0 4.5 15.9 10.2 5.9 12.8 11.2 13.4 7.4 7.1 8.0 4.6 6.1 17.3 4.7 5.2 9.9 17.2 19.2 8.9 9.4 4.0 7.1 18.5 8.2 9.5 17.4 23.9 17.6 20.6 13.1 12.3 13.9 15.6 17.7 7.4 17.1 18.3 9.3 8.1 18.7 20.3 17.7 16.8 18.2 11.5 12.1 16.3 9.5 18.0 16.1 6.1 18.2 18.1 10.6 17.9 11.4 12.4 17.9 20.9 19.2 11.1 4.9 14.4 4.1 18.6 14.8 18.4 14.1 30.3 14.2 15.3 15.9 15.8 8.7 27.5 25.4 23.7 16.7 20.9 11.9 10.8 12.1 7.6 15.9 11.0 12.7 14.1 9.1 13.8 10.7 5.3 2.1 1.2 0.8 2.2 1.5 2.4 1.9 2.0 1.9 1.2 2.1 1.8 1.9 1.1 2.0 1.4 1.3 1.5 1.1 4.4 5.2 4.3 4.9 4.2 5.0 5.6 4.6 4.5 4.6 5.2 7.1 9.6 22.4 36.4 29.0 9.6 6.8 6.5 9.8 13.6 22.2 11.9 8.5 65.9 18.6 11.3 12.9 39.6 19.8 10.9 11.4 50.9 10.0 0.8 18.5 20.5 11.7 9.1 8.2 24.0 8.5 11.6 11.3 15.8 15.4 2.5 19.6 15.4 53.2 8.7 15.2 25.2 12.0 14.2 8.8 5.0 1.7 15.2 7.3 3.6 3.7 10.3 14.5 12.3 22.1 26.1 6.4 6.0 21.1 7.1 9.4 9.9 32.1 18.0 22.4 6.6 15.0 12.9 2.8 6.1 18.7 7.2 8.2 9.7 17.3 15.1 5.5 DCAF1 "KIAA0800, MGC102804, VPRBP" ENSG00000145041 "DDB1 and CUL4 associated factor 1" Q9Y4B6 3 51395867-51500002 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction, Transcription, Transcription regulation, Ubl conjugation pathway" "Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 53.4" "Cell type enhanced" "Detected in many" "Glandular and luminal cells: 17.9;Granulosa cells: 13.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036142, HPA052445, HPA053203" Approved Supported "Nucleoplasm,Nucleoli fibrillar center" No No "Cluster 27: Non-specific - Gene expression" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "Nucleoli fibrillar center" "HPA036142: AB_10669666, HPA052445: AB_2681835, HPA053203: AB_2682080" "unprognostic (7.51e-2)" "unprognostic (3.19e-1)" "unprognostic (3.71e-3)" "unprognostic (1.26e-1)" "unprognostic (5.15e-2)" "unprognostic (9.75e-2)" "unprognostic (2.58e-2)" "unprognostic (1.24e-1)" "unprognostic (8.75e-2)" "unprognostic (2.15e-1)" "unprognostic (2.89e-2)" "unprognostic (2.21e-2)" "prognostic favorable (7.45e-5)" "unprognostic (5.49e-2)" "unprognostic (5.00e-1)" "unprognostic (6.81e-2)" "unprognostic (1.64e-1)" 11.4 11.3 7.6 11.7 8.8 15.9 11.2 11.2 9.4 9.4 9.8 11.0 7.9 10.3 9.4 10.6 8.9 7.4 9.5 7.8 9.3 11.0 11.5 10.0 14.8 8.4 8.8 10.3 10.4 18.9 8.6 10.3 8.6 9.7 10.9 19.7 11.3 9.6 27.9 13.5 11.4 9.2 8.0 11.3 10.3 53.4 8.5 18.6 14.6 16.1 15.9 11.2 10.0 9.0 19.9 23.9 22.8 20.7 20.1 15.9 21.6 21.8 16.2 23.1 22.5 26.4 18.8 48.1 11.7 17.2 35.3 17.1 43.3 19.5 29.6 33.7 21.5 41.2 32.4 22.8 14.7 54.4 28.7 10.6 22.2 29.8 21.6 15.0 18.2 26.1 24.5 30.3 18.3 20.3 41.8 22.0 24.0 23.5 26.0 17.5 24.4 32.0 18.0 30.5 11.8 21.0 24.1 22.0 13.2 16.7 15.0 22.8 22.9 18.8 25.1 31.4 33.9 20.5 29.7 48.2 21.9 36.6 15.7 2.5 3.0 2.4 6.5 3.3 7.4 5.1 5.6 5.6 4.8 4.9 6.0 5.1 0.7 5.8 5.0 3.8 6.7 4.9 7.6 8.8 11.2 9.4 7.8 9.3 8.4 8.8 8.6 8.0 8.5 9.0 11.1 3.2 10.6 0.0 3.6 0.0 0.0 0.0 0.0 0.0 11.3 9.4 0.0 0.0 6.8 3.7 0.0 7.6 9.7 0.0 1.9 7.0 0.0 11.2 10.3 5.6 0.0 0.0 0.0 6.7 5.7 3.0 0.0 17.9 6.3 13.1 0.0 0.0 7.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.9 0.0 0.0 2.6 0.0 0.0 0.0 0.0 7.5 0.0 0.0 2.8 0.0 0.0 6.1 5.1 0.0 0.0 0.0 3.5 0.0 0.0 0.0 0.0 10.5 5.0 7.4 0.0 0.0 DCK ENSG00000156136 "Deoxycytidine kinase" P27707 4 70992538-71030914 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 105.8" "Cell type enhanced" "Detected in many" "B-cells: 105.7;Erythroid cells: 284.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Daudi: 232.9;U-698: 191.8" "Low region specificity" "Detected in all" "HPA059609, HPA062773" Enhanced Supported Nucleoplasm NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 3: T-cells - Adaptive immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 6: Erythroid cells - Oxygen transport" Nucleoplasm "HPA059609: AB_2684082, HPA062773: AB_2684865" "unprognostic (9.16e-2)" "unprognostic (2.44e-1)" "unprognostic (5.24e-3)" "unprognostic (4.77e-2)" "unprognostic (3.95e-1)" "unprognostic (6.45e-2)" "prognostic unfavorable (6.90e-7)" "unprognostic (3.04e-2)" "unprognostic (7.19e-2)" "unprognostic (8.28e-2)" "unprognostic (4.51e-1)" "unprognostic (1.33e-1)" "unprognostic (3.37e-2)" "unprognostic (4.47e-2)" "unprognostic (6.82e-2)" "unprognostic (1.33e-1)" "unprognostic (2.27e-2)" 11.1 15.2 10.1 36.3 11.2 43.9 12.5 9.7 13.6 9.9 11.0 15.7 13.7 13.4 7.2 14.6 9.8 12.4 10.4 10.7 10.7 9.8 9.2 13.4 92.9 10.9 10.4 10.6 8.3 8.8 3.5 15.3 10.8 10.2 18.9 17.1 7.7 7.1 9.5 14.7 15.9 13.9 11.4 32.3 14.2 9.0 9.7 105.8 15.7 12.1 79.6 14.2 6.1 13.4 25.8 17.2 38.5 23.9 12.4 20.4 21.0 65.3 25.6 53.3 43.6 11.3 56.1 232.9 24.7 28.3 31.0 14.8 34.6 21.4 71.0 43.5 16.2 46.6 18.6 20.5 11.8 95.8 58.5 11.2 25.5 32.2 19.5 26.0 31.0 64.4 19.0 93.2 62.0 15.5 126.6 39.5 17.2 45.6 15.6 96.0 74.0 18.6 26.6 18.8 35.1 31.8 24.9 49.6 29.7 17.4 22.3 54.3 22.0 60.1 41.8 47.6 37.1 31.7 21.2 191.8 40.7 60.0 45.0 25.6 17.2 28.9 24.2 20.5 32.0 44.5 33.0 30.6 23.8 41.1 34.2 34.2 8.1 34.4 21.0 63.6 41.2 45.1 10.1 11.2 9.7 13.6 10.7 10.7 10.9 10.4 10.8 11.4 9.7 13.4 16.4 0.0 8.6 6.8 105.7 43.0 10.1 11.9 27.9 16.1 10.4 5.2 6.5 7.2 7.5 12.9 6.2 11.9 97.7 10.4 29.4 19.2 0.7 5.9 7.0 16.3 21.0 284.8 17.1 6.2 19.3 11.0 8.6 7.4 22.9 7.5 22.9 7.2 38.2 18.5 21.0 16.4 22.4 63.2 74.5 2.3 8.4 56.0 46.2 18.7 61.4 15.8 84.5 8.0 11.1 10.5 8.0 10.1 24.6 11.6 7.1 10.0 4.7 10.7 6.6 9.3 15.9 52.0 33.9 28.0 43.3 4.5 62.4 4.8 16.5 8.4 DCLK1 "DCAMKL1, DCDC3A, DCLK, KIAA0369" ENSG00000133083 "Doublecortin like kinase 1" O15075 13 35768652-36131382 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Differentiation, Neurogenesis" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 53.0" "Group enriched" "Detected in many" 6 "Excitatory neurons: 970.6;Inhibitory neurons: 664.8" "Cancer enhanced" "Detected in many" "glioma: 12.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "ASC diff: 29.0;ASC TERT1: 27.3;fHDF/TERT166: 23.5;GAMG: 34.8;HAP1: 17.9;HSkMC: 25.5;NTERA-2: 37.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB012405, HPA015040, HPA015655" Enhanced Approved Nucleoplasm,Cytosol NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm Cytosol "CAB012405: , HPA015040: AB_2669141, HPA015655: AB_2669265" "unprognostic (2.29e-1)" "unprognostic (2.56e-1)" "unprognostic (7.45e-2)" "unprognostic (1.30e-2)" "unprognostic (1.99e-1)" "unprognostic (2.35e-2)" "unprognostic (1.48e-1)" "unprognostic (3.30e-2)" "unprognostic (1.66e-1)" "unprognostic (1.74e-1)" "unprognostic (7.72e-2)" "unprognostic (2.85e-1)" "prognostic unfavorable (4.42e-4)" "unprognostic (1.93e-3)" "unprognostic (1.29e-1)" "unprognostic (1.34e-1)" "unprognostic (1.14e-4)" 15.5 2.5 22.0 4.0 27.5 0.0 14.2 10.2 45.3 11.8 0.0 4.2 1.1 6.0 4.1 5.4 4.6 7.2 5.5 37.1 37.8 2.8 0.1 2.4 4.2 17.9 13.2 6.1 1.2 1.1 13.7 0.1 53.0 4.1 3.8 17.3 3.4 4.0 2.1 8.4 4.1 19.1 15.7 4.5 3.6 1.3 17.5 1.6 2.8 4.6 2.2 4.3 5.9 18.7 0.0 0.4 6.8 0.0 29.0 27.3 0.0 0.2 0.4 0.2 0.2 0.0 0.1 0.0 0.0 23.5 34.8 0.0 17.9 0.3 0.0 0.0 1.0 0.0 0.8 0.0 1.1 0.0 0.0 25.5 13.0 0.6 0.4 0.0 0.2 0.0 0.0 0.1 0.3 0.1 0.0 0.0 37.1 0.0 0.4 0.0 2.0 0.0 1.0 0.0 7.3 4.4 0.0 0.0 2.2 10.4 0.0 0.0 0.0 0.1 6.1 7.6 1.3 0.1 0.0 0.0 2.4 0.0 7.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 22.0 27.5 10.2 45.3 37.1 37.8 17.9 13.2 53.0 15.7 17.5 18.7 8.0 9.6 0.6 132.2 0.1 15.2 1.3 1.8 0.0 9.4 7.8 7.0 5.8 0.0 7.9 3.7 4.2 0.0 0.0 0.0 0.0 0.1 1.5 0.7 1.7 3.8 0.0 0.0 970.6 0.0 0.0 82.6 0.5 0.3 0.0 75.5 0.4 0.0 0.1 10.1 664.8 0.0 4.1 0.3 14.7 1.6 20.8 0.7 14.2 44.0 0.0 73.8 0.0 31.2 19.1 0.2 0.0 4.1 0.3 0.6 0.0 0.6 3.1 4.2 6.6 10.8 22.0 1.3 1.4 1.0 9.7 0.0 0.8 30.1 0.0 1.7 DCLK2 "DCAMKL2, DCDC3, DCDC3B, DCK2, MGC45428" ENSG00000170390 "Doublecortin like kinase 2" Q8N568 4 150078445-150257438 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 59.0" "Group enriched" "Detected in many" 6 "Astrocytes: 501.1;Excitatory neurons: 189.8;Inhibitory neurons: 173.2;Oligodendrocyte precursor cells: 172.4" "Cancer enriched" "Detected in many" 17 "glioma: 53.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 23.6;BJ: 11.8;BJ hTERT+: 24.9;fHDF/TERT166: 11.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA015770 Enhanced Approved NA NA "Cluster 19: B-cells - Humoral immune response" "Cluster 65: Brain - Ion transport" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 64: Astrocytes - Nervous system maintenance" "HPA015770: AB_1847509" "unprognostic (7.37e-2)" "unprognostic (1.56e-3)" "unprognostic (9.30e-2)" "unprognostic (1.49e-2)" "unprognostic (4.06e-1)" "unprognostic (6.24e-3)" "unprognostic (1.90e-1)" "unprognostic (7.38e-3)" "unprognostic (2.18e-1)" "prognostic favorable (3.25e-4)" "prognostic favorable (2.48e-4)" "unprognostic (6.87e-2)" "unprognostic (3.93e-3)" "unprognostic (3.74e-3)" "unprognostic (4.53e-2)" "unprognostic (1.48e-1)" "unprognostic (1.45e-2)" 1.7 2.8 45.8 0.9 42.0 0.5 1.4 34.6 43.6 2.0 7.7 5.6 1.4 2.7 2.0 1.5 1.9 2.5 12.2 59.0 41.2 2.3 0.6 2.1 0.4 41.2 46.6 2.9 2.2 0.6 8.3 1.5 38.4 2.7 2.0 18.4 0.8 2.0 1.2 1.0 2.2 4.7 46.6 1.2 2.3 2.8 42.7 0.2 2.6 1.4 0.3 2.6 1.3 46.8 1.2 4.2 23.6 3.7 0.0 1.1 0.4 11.8 24.9 3.5 0.9 0.1 0.0 0.0 0.4 11.0 3.6 0.1 3.5 0.0 4.4 5.1 2.1 0.0 7.0 0.0 5.0 0.7 0.7 0.6 0.0 2.2 0.2 2.2 1.2 0.6 0.0 0.1 2.5 0.2 0.4 0.0 0.5 0.3 1.6 0.0 2.8 1.0 0.1 1.0 9.2 9.1 4.7 3.4 1.0 2.0 0.0 0.1 2.1 3.3 1.3 2.2 1.3 1.1 0.0 0.1 3.1 0.2 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 45.8 42.0 34.6 43.6 59.0 41.2 41.2 46.6 38.4 46.6 42.7 46.8 10.7 0.0 0.0 501.1 0.6 0.5 0.1 0.0 0.6 26.2 2.8 2.2 10.5 1.5 0.7 3.7 16.7 0.0 0.0 0.8 0.0 0.4 0.1 0.4 4.6 7.6 3.0 0.0 189.8 0.7 0.0 3.4 1.1 0.5 4.5 5.7 7.5 0.0 1.6 35.3 173.2 0.3 0.0 0.6 3.4 0.3 1.8 0.7 5.4 43.1 0.2 31.2 0.0 172.4 37.6 0.1 0.4 3.8 0.3 0.6 0.0 0.4 0.1 9.6 13.1 5.6 9.2 0.1 2.0 0.1 0.6 0.3 0.9 6.6 1.4 0.2 DCLK3 "DCAMKL3, DCDC3C, KIAA1765" ENSG00000163673 "Doublecortin like kinase 3" Q9C098 3 36712422-36764349 "Enzymes, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 3.9;testis: 2.8" "Cell type enriched" "Detected in some" 6 "Early spermatids: 53.8" "Cancer enriched" "Detected in single" 5 "testis cancer: 1.2" "Region enhanced" "Detected in some" "basal ganglia: 3.9" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA040685, HPA053234" Approved Approved Vesicles,Cytosol NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 23: Spermatids - Flagellum & Golgi organization" Cytosol Vesicles "HPA040685: AB_2732487, HPA053234: " "unprognostic (9.09e-3)" "unprognostic (1.41e-3)" "unprognostic (2.75e-1)" "unprognostic (2.66e-2)" "unprognostic (2.41e-1)" "unprognostic (1.80e-1)" "unprognostic (1.40e-2)" "unprognostic (1.08e-2)" "unprognostic (1.96e-2)" "unprognostic (1.86e-2)" "unprognostic (2.05e-1)" "unprognostic (7.07e-2)" "unprognostic (6.11e-5)" "unprognostic (7.94e-3)" "unprognostic (5.80e-2)" "unprognostic (3.25e-3)" "unprognostic (1.36e-2)" 0.5 0.1 0.9 0.4 3.9 0.1 0.2 0.1 1.8 0.1 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.1 0.2 0.8 0.7 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.1 0.2 1.0 0.3 0.0 0.0 0.1 1.5 0.1 0.0 0.9 0.1 0.1 0.3 1.4 0.0 0.0 2.8 0.7 1.3 0.3 0.9 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.7 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 3.9 0.1 1.8 0.8 0.7 0.3 0.2 0.0 1.4 0.7 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.0 0.0 0.1 1.2 0.0 0.0 0.0 0.0 0.5 0.0 0.1 0.0 0.0 53.8 0.1 0.1 0.5 0.0 0.0 1.6 0.0 0.0 0.2 0.0 0.2 0.0 0.2 0.0 0.0 2.0 0.0 0.9 0.0 0.0 0.0 0.4 8.9 0.3 0.1 0.0 0.0 0.0 0.9 0.0 0.5 0.1 0.0 1.1 0.0 0.0 0.0 0.0 0.1 0.0 2.1 0.0 0.1 3.3 1.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 DCST1 FLJ32785 ENSG00000163357 "DC-STAMP domain containing 1" Q5T197 1 155033824-155050930 "Enzymes, Predicted membrane proteins" "Immunity, Innate immunity, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "retina: 2.6;skin 1: 3.1;testis: 6.7" "Cell type enhanced" "Detected in some" "Cone photoreceptor cells: 12.5;Early spermatids: 37.0;Late spermatids: 18.8;Rod photoreceptor cells: 6.6" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HaCaT: 2.1;HeLa: 2.2;RPMI-8226: 2.4" "Not detected" "Not detected" "Not detected" "Not detected" HPA060314 Uncertain NA NA "Cluster 27: Brain & Skin - Unknown function" "Cluster 25: RPMI-8226 - Immune response" "Cluster 23: Spermatids - Flagellum & Golgi organization" "HPA060314: AB_2684250" "unprognostic (1.44e-1)" "unprognostic (7.66e-2)" "unprognostic (3.77e-2)" "unprognostic (1.05e-4)" "unprognostic (3.58e-2)" "unprognostic (8.75e-4)" "unprognostic (1.46e-2)" "unprognostic (2.66e-1)" "unprognostic (6.01e-3)" "unprognostic (2.22e-1)" "unprognostic (6.62e-2)" "unprognostic (1.89e-2)" "unprognostic (8.33e-15)" "unprognostic (7.77e-2)" "unprognostic (2.22e-1)" "unprognostic (2.38e-1)" "unprognostic (1.23e-1)" 0.1 0.1 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.1 0.8 0.0 0.0 0.2 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 2.6 0.3 0.0 0.0 3.1 0.8 0.0 0.0 0.1 0.2 6.7 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.6 0.3 1.1 0.6 0.0 0.0 0.4 0.2 0.0 0.0 0.0 0.2 1.4 0.7 0.2 0.0 0.3 2.1 0.0 0.0 0.0 0.5 0.1 0.1 2.2 0.1 0.0 0.5 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.5 1.0 0.0 0.4 0.0 0.1 0.1 0.1 0.9 0.0 0.4 2.4 0.0 0.3 0.3 0.7 0.2 0.8 0.1 0.4 1.5 0.0 0.0 0.1 0.1 0.3 0.1 0.4 0.4 0.1 0.3 0.7 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.3 0.1 0.0 0.0 1.0 0.2 0.0 0.7 0.0 1.3 0.0 12.5 0.0 0.0 0.0 0.0 0.0 37.0 0.1 0.1 0.1 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.3 18.8 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.7 6.6 0.0 0.0 0.1 0.9 0.2 0.0 0.1 0.0 0.1 0.0 0.0 0.0 DDR1 "CAK, CD167, EDDR1, NEP, NTRK4, PTK3A, RTK6" ENSG00000204580 "Discoidin domain receptor tyrosine kinase 1" Q08345 6 30876421-30900156 "CD markers, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Lactation, Pregnancy" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HaCaT: 90.9;HBEC3-KT: 70.1;RT4: 93.5;T-47d: 103.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010162, CAB025656, HPA057194" Approved Approved "Nucleoplasm,Cell Junctions" "Intracellular and membrane" NA NA 4400000 "Cluster 30: Non-specific - Translation" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 15: RT4 - Unknown function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Nucleoplasm, Cell Junctions" "CAB010162: AB_2092090, CAB025656: , HPA057194: " "unprognostic (2.11e-2)" "unprognostic (9.31e-2)" "unprognostic (1.01e-1)" "unprognostic (1.09e-1)" "unprognostic (2.07e-1)" "unprognostic (7.75e-3)" "unprognostic (6.43e-2)" "unprognostic (1.92e-1)" "unprognostic (1.73e-1)" "unprognostic (1.42e-1)" "unprognostic (1.50e-1)" "unprognostic (4.41e-2)" "prognostic favorable (3.31e-10)" "unprognostic (1.42e-1)" "unprognostic (2.53e-1)" "unprognostic (5.49e-3)" "unprognostic (4.09e-2)" 26.5 50.4 24.1 5.3 49.5 0.4 54.6 47.9 20.2 55.2 4.8 57.7 12.3 23.4 4.5 150.1 46.2 11.4 42.1 17.5 40.7 96.8 6.3 33.7 1.2 68.7 47.3 41.5 99.7 19.7 67.9 4.2 57.9 70.2 10.7 4.5 131.7 13.8 40.5 121.1 47.3 1.1 38.8 11.5 71.1 16.5 46.3 7.0 85.9 4.3 3.0 45.0 88.4 58.9 58.2 18.5 26.0 5.4 1.7 2.4 16.2 1.4 0.4 0.8 0.1 25.2 29.8 0.5 30.9 5.1 26.8 90.9 5.7 70.1 0.3 32.0 9.9 0.2 18.7 6.7 5.0 0.0 1.2 3.3 35.4 0.4 0.5 16.1 2.0 1.4 17.3 0.7 4.0 36.5 2.0 0.1 4.5 31.8 3.8 3.9 19.5 2.2 13.1 93.5 4.7 2.5 5.4 41.4 19.4 8.6 103.0 0.6 4.3 12.8 11.7 1.2 13.6 0.8 0.1 2.6 8.4 0.0 11.2 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.1 0.0 0.2 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.2 24.1 49.5 47.9 20.2 17.5 40.7 68.7 47.3 57.9 38.8 46.3 58.9 1.9 35.3 24.6 54.5 3.8 53.0 68.3 125.5 67.2 7.4 77.0 57.9 18.0 37.1 79.8 90.1 0.0 63.6 1.5 109.7 5.9 125.5 15.1 58.5 6.5 4.1 46.2 2.7 1.2 76.2 26.0 7.4 63.7 58.4 1.3 29.5 2.2 0.6 6.1 6.7 7.5 69.8 109.9 0.8 5.4 30.1 8.4 2.5 16.0 9.4 13.1 139.9 1.0 60.3 73.8 71.5 78.2 5.3 0.8 68.1 77.3 5.4 104.2 8.0 6.6 10.5 11.9 1.5 6.8 81.8 51.9 46.5 1.9 4.1 67.1 88.4 DDR2 "NTRKR3, TKT, TYRO10" ENSG00000162733 "Discoidin domain receptor tyrosine kinase 2" Q16832 1 162631373-162787405 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Osteogenesis "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, Dwarfism, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 89.8;Fibroblasts: 116.5;Leydig cells: 63.0;Peritubular cells: 88.4;Skeletal myocytes: 98.2;Smooth muscle cells: 78.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 233.3;ASC TERT1: 214.4;BJ hTERT+: 163.4;fHDF/TERT166: 137.6;HSkMC: 157.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA070112 Approved "Plasma membrane,Actin filaments" Yes No 770000 "Cluster 57: Non-specific - Angiogenesis" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "Plasma membrane, Actin filaments" "HPA070112: AB_2686229" "unprognostic (4.12e-2)" "unprognostic (2.73e-1)" "unprognostic (6.97e-3)" "unprognostic (4.52e-2)" "unprognostic (1.17e-1)" "unprognostic (8.16e-2)" "unprognostic (1.81e-1)" "unprognostic (1.19e-1)" "unprognostic (6.62e-2)" "unprognostic (2.24e-2)" "unprognostic (1.00e-1)" "unprognostic (1.15e-1)" "prognostic unfavorable (1.73e-7)" "unprognostic (1.56e-3)" "unprognostic (8.26e-3)" "unprognostic (7.57e-2)" "unprognostic (4.10e-3)" 59.8 64.3 13.2 15.8 11.3 0.3 25.2 10.4 9.2 33.7 51.5 54.7 5.8 26.2 13.2 18.1 22.4 23.8 24.1 12.6 24.5 6.4 5.4 14.5 9.1 37.0 22.1 37.4 3.7 2.5 5.4 10.6 31.7 17.3 14.1 5.1 9.8 29.2 4.9 9.7 17.6 42.8 17.8 5.8 20.4 3.9 21.0 3.3 12.9 19.3 6.9 23.2 23.6 25.2 0.3 0.0 0.2 63.2 233.3 214.4 1.0 92.2 163.4 41.5 56.8 0.0 0.2 0.0 0.1 137.6 8.9 0.1 0.3 0.4 54.0 42.9 0.3 0.0 0.4 0.1 103.9 0.2 0.2 157.0 0.4 73.1 2.2 65.8 46.0 0.4 0.6 16.8 36.9 0.1 0.0 0.3 0.4 0.1 0.3 0.1 24.1 0.7 0.2 0.2 0.3 35.4 0.2 0.1 2.9 3.6 0.2 0.3 2.1 58.5 13.8 29.1 12.6 2.6 4.0 0.1 56.3 0.1 62.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.2 11.3 10.4 9.2 12.6 24.5 37.0 22.1 31.7 17.8 21.0 25.2 23.4 3.2 2.3 53.2 2.5 12.6 3.9 0.8 1.2 3.0 6.0 15.6 31.3 1.5 1.1 0.0 0.0 0.5 1.7 3.2 0.0 0.4 8.9 5.0 89.8 22.3 1.2 0.0 13.1 1.8 0.5 116.5 2.6 8.2 1.3 16.7 30.0 3.5 1.2 0.0 26.2 1.0 0.0 1.9 19.3 7.1 63.0 3.1 23.2 29.0 0.0 16.5 2.1 6.0 5.6 1.8 4.4 88.4 5.6 5.9 1.2 2.1 2.4 3.0 39.5 98.2 78.3 1.0 0.9 2.0 8.7 1.0 2.5 34.2 0.8 4.2 DGAT1 "ARGP1, DGAT" ENSG00000185000 "Diacylglycerol O-acyltransferase 1" O75907 8 144314584-144326910 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Acyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 40.6" "Group enriched" "Detected in many" 4 "Distal enterocytes: 213.5;Proximal enterocytes: 700.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "Hep G2: 18.4;PC-3: 21.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB032853 Enhanced Approved "Nucleoli,Nucleoli rim,Endoplasmic reticulum" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 39: CACO-2 - Unknown function" "Cluster 45: Enterocytes - Digestion" "Endoplasmic reticulum" "Nucleoli, Nucleoli rim" "CAB032853: AB_2090798" "unprognostic (9.24e-3)" "unprognostic (1.61e-1)" "unprognostic (1.75e-2)" "unprognostic (2.23e-1)" "unprognostic (3.49e-2)" "unprognostic (2.30e-1)" "unprognostic (1.11e-1)" "unprognostic (1.42e-2)" "unprognostic (5.10e-2)" "unprognostic (2.78e-2)" "unprognostic (6.88e-2)" "unprognostic (3.52e-1)" "unprognostic (2.65e-3)" "unprognostic (3.83e-2)" "unprognostic (1.69e-2)" "unprognostic (1.16e-1)" "unprognostic (1.67e-3)" 15.0 24.7 4.6 1.8 4.6 5.1 11.8 5.5 5.6 6.1 4.1 16.7 37.0 5.6 1.0 8.6 5.1 2.0 11.7 4.7 4.1 7.9 16.5 6.9 1.8 4.5 4.6 4.3 6.5 3.9 6.5 1.5 4.2 6.6 4.2 1.6 7.4 2.4 11.7 6.9 40.6 1.6 4.1 9.3 8.7 14.7 4.4 2.3 7.4 3.5 1.4 6.7 6.4 4.5 5.2 4.9 2.2 4.1 3.5 1.5 2.9 3.4 3.1 2.9 2.0 11.2 3.1 2.1 12.4 1.9 1.6 4.0 1.8 4.3 0.6 3.7 5.1 3.3 4.2 18.4 2.5 1.0 3.4 2.1 3.2 2.0 2.1 2.1 2.3 7.3 2.9 5.2 1.9 3.7 6.8 4.1 1.1 10.9 21.2 7.7 0.9 3.4 2.8 2.5 2.6 4.2 4.7 5.2 2.3 0.8 2.9 3.3 2.0 1.6 5.6 3.6 2.8 2.3 0.6 0.8 1.8 6.3 3.2 0.0 0.4 0.7 0.2 0.3 0.4 0.1 0.2 0.2 0.5 0.1 0.1 0.0 0.5 0.0 0.4 0.2 0.1 0.2 4.6 4.6 5.5 5.6 4.7 4.1 4.5 4.6 4.2 4.1 4.4 4.5 34.0 16.0 19.0 15.7 8.5 8.0 12.5 6.3 4.0 24.6 21.6 16.0 20.8 12.8 8.7 18.4 29.2 11.3 17.6 213.5 1.9 9.4 19.2 12.3 13.7 26.5 23.4 17.7 11.2 11.9 10.3 9.3 48.4 21.3 7.0 23.9 12.5 57.4 18.8 18.5 12.8 93.6 4.1 25.5 11.8 25.8 6.8 22.8 5.4 8.4 9.2 21.3 4.1 17.6 7.0 13.3 113.4 6.8 18.8 8.1 700.1 7.4 5.6 23.6 0.0 11.9 12.3 27.7 17.4 12.3 9.2 16.4 12.3 41.1 108.0 20.7 DGAT2 ENSG00000062282 "Diacylglycerol O-acyltransferase 2" Q96PD7 11 75759512-75801535 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycerol metabolism, Lipid biosynthesis, Lipid metabolism" "Acyltransferase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 7 "adipose tissue: 476.0;breast: 133.6;liver: 331.8;skin 1: 151.5" "Cell type enhanced" "Detected in many" "Early spermatids: 259.3;Hepatocytes: 116.4;Late spermatids: 64.1;Spermatocytes: 53.9;Spermatogonia: 53.5" "Cancer enhanced" "Detected in many" "liver cancer: 19.9" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 11 "eosinophil: 137.7;neutrophil: 348.6" "Lineage enriched" "Detected in many" 16 "granulocytes: 348.6" "Cell line enhanced" "Detected in many" "ASC diff: 80.4;HDLM-2: 62.5;Hep G2: 64.9;OE19: 124.0" "Low region specificity" "Detected in all" "Region enriched" "Detected in all" 4 "basal ganglia: 22.0" HPA013351 Approved Vesicles,Cytosol NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 21: OE19 - Mitochondria" "Cluster 29: Early spermatids - Spermatogenesis" "Vesicles, Cytosol" "HPA013351: AB_1847630" "unprognostic (2.28e-1)" "unprognostic (3.69e-1)" "unprognostic (9.38e-2)" "prognostic unfavorable (2.84e-4)" "unprognostic (3.63e-1)" "unprognostic (4.99e-2)" "unprognostic (1.10e-2)" "unprognostic (7.59e-2)" "unprognostic (4.46e-1)" "unprognostic (4.12e-3)" "unprognostic (2.87e-1)" "unprognostic (2.99e-1)" "unprognostic (1.49e-7)" "unprognostic (2.03e-1)" "unprognostic (2.85e-1)" "unprognostic (2.74e-2)" "unprognostic (5.60e-2)" 476.0 5.1 5.8 19.4 11.7 7.2 133.6 2.9 6.1 2.6 5.3 9.0 14.5 1.2 1.8 24.1 2.1 5.8 11.7 5.7 6.4 3.4 331.8 5.6 4.0 3.7 3.9 1.8 4.6 2.1 1.6 1.5 5.5 2.2 4.9 0.6 10.5 1.6 4.1 151.5 16.5 2.8 3.4 15.0 12.8 38.1 6.9 4.3 8.8 5.6 18.2 21.3 12.6 5.1 13.3 6.4 0.4 11.2 80.4 6.4 1.0 1.3 1.7 1.6 1.0 46.6 13.5 21.1 16.8 0.3 11.9 0.5 1.8 6.5 4.4 62.5 1.2 1.5 4.0 64.9 0.9 7.4 7.2 26.8 33.6 7.3 10.6 4.4 1.2 20.9 1.2 27.6 0.7 8.5 5.1 16.7 3.6 124.0 31.5 0.0 0.1 24.8 1.2 35.8 22.6 1.4 12.3 1.9 2.9 2.7 4.4 26.6 1.6 14.1 7.0 0.3 9.1 16.3 40.0 28.8 10.2 23.7 25.3 19.4 22.1 137.7 0.0 4.4 0.4 7.4 0.4 0.0 6.1 7.6 0.1 0.2 348.6 0.0 5.0 1.8 0.0 5.7 5.8 11.7 2.9 6.1 5.7 6.4 3.7 3.9 5.5 3.4 6.9 5.1 3.2 6.4 5.4 0.3 5.0 1.1 0.9 3.0 0.6 0.9 5.2 7.0 3.5 0.0 2.7 0.0 2.1 0.5 0.3 0.6 0.0 1.7 259.3 3.3 0.2 0.5 1.2 2.7 2.9 0.5 0.1 0.7 10.7 0.2 0.0 2.1 2.9 116.4 2.2 1.7 1.3 4.8 0.0 4.1 13.1 64.1 2.1 4.2 1.8 0.0 4.0 0.4 0.0 0.0 1.0 3.7 2.2 0.7 0.9 2.8 1.2 2.2 3.4 0.0 6.6 0.6 1.0 53.9 53.5 0.3 8.0 0.8 0.5 0.2 3.0 15.7 DGKA "DAGK, DAGK1, DGK-alpha" ENSG00000065357 "Diacylglycerol kinase alpha" P23743 12 55927319-55954027 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Lipid metabolism" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "esophagus: 101.5;lymphoid tissue: 198.1" "Cell type enhanced" "Detected in many" "Proximal enterocytes: 49.0;Squamous epithelial cells: 40.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Lineage enriched" "Detected in all" 4 "T-cells: 86.9" "Cell line enhanced" "Detected in many" "HBEC3-KT: 130.4;hTERT-HME1: 133.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041645, HPA045462" Approved Approved Nucleoplasm,Vesicles,Mitochondria NA NA "Cluster 20: T-cells - T-cell receptor" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 30: Epithelial cell lines - Translation" "Cluster 58: T-cells - T-cell receptor" Vesicles "Nucleoplasm, Mitochondria" "HPA041645: AB_2677595, HPA045462: AB_2679335" "unprognostic (1.12e-3)" "unprognostic (1.43e-2)" "unprognostic (1.62e-2)" "unprognostic (2.63e-2)" "unprognostic (5.23e-2)" "unprognostic (2.04e-1)" "unprognostic (3.62e-1)" "unprognostic (3.31e-2)" "unprognostic (5.28e-2)" "unprognostic (1.94e-1)" "unprognostic (1.82e-2)" "unprognostic (2.46e-1)" "prognostic unfavorable (1.66e-5)" "unprognostic (4.06e-1)" "unprognostic (1.00e-1)" "unprognostic (1.47e-1)" "unprognostic (7.02e-2)" 12.7 12.8 7.6 50.0 9.8 31.9 11.0 6.6 9.2 22.9 7.0 25.6 51.2 13.1 9.9 101.5 11.4 15.8 8.5 7.2 5.2 7.9 3.7 18.6 95.5 5.2 5.0 10.9 14.6 12.0 6.9 14.9 5.3 24.8 26.9 2.8 35.5 9.6 2.3 84.7 64.8 14.1 4.8 53.8 12.4 12.3 5.0 198.1 10.5 4.2 101.8 28.4 39.0 6.8 22.2 13.2 9.3 12.4 22.4 29.0 2.8 47.2 47.8 18.2 13.5 6.9 35.2 13.5 11.1 31.5 6.2 38.7 10.3 130.4 21.4 14.4 2.5 21.1 26.8 3.6 19.1 6.7 20.9 25.1 68.4 25.2 133.9 60.6 37.9 78.8 2.4 18.7 49.4 2.3 54.3 8.6 2.0 18.1 15.5 23.8 2.9 2.0 43.7 60.9 1.6 5.6 15.5 0.9 1.7 23.8 9.3 6.4 34.0 12.0 8.4 2.8 1.7 2.9 1.2 32.4 13.8 17.5 3.4 17.0 7.4 15.3 18.5 5.2 35.5 20.4 70.6 33.0 10.5 16.2 86.9 51.5 13.3 14.1 3.5 10.5 86.7 36.2 7.6 9.8 6.6 9.2 7.2 5.2 5.2 5.0 5.3 4.8 5.0 6.8 4.5 3.2 6.5 1.6 25.7 15.0 9.7 21.1 26.7 1.2 4.0 4.6 2.9 4.3 19.1 5.5 0.0 16.3 12.2 35.4 0.0 5.1 9.4 1.9 6.5 5.3 2.4 11.2 11.2 9.4 4.3 8.2 15.3 3.0 7.0 2.4 4.2 0.2 4.2 0.0 5.2 7.7 2.0 6.9 21.6 7.0 3.7 14.0 0.0 5.6 15.7 2.6 10.3 9.0 0.8 25.3 14.4 3.0 14.8 8.2 49.0 0.3 5.2 0.5 6.6 1.5 4.2 6.6 4.2 40.4 13.9 26.4 37.4 1.6 9.7 20.1 DGKB "DAGK2, DGK, DGK-BETA, KIAA0718" ENSG00000136267 "Diacylglycerol kinase beta" Q9Y6T7 7 14145049-14974777 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 10 "brain: 32.3" "Group enriched" "Detected in some" 8 "Excitatory neurons: 937.7;Inhibitory neurons: 576.6;Oligodendrocyte precursor cells: 254.3" "Cancer enriched" "Detected in single" 11 "glioma: 1.7" "Group enriched" "Detected in many" 7 "basal ganglia: 32.3;cerebral cortex: 14.4;hippocampal formation: 9.2;hypothalamus: 11.9" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 1.2;fHDF/TERT166: 2.6;SCLC-21H: 1.3;U-266/70: 3.3" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "basal ganglia: 192.8" HPA020321 Supported NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 29: U-266 - Adaptive immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA020321: " "unprognostic (9.89e-2)" "unprognostic (9.72e-5)" "unprognostic (1.45e-1)" "unprognostic (2.88e-3)" "unprognostic (4.32e-2)" "unprognostic (3.37e-1)" "unprognostic (7.34e-2)" "unprognostic (5.91e-2)" "unprognostic (6.19e-2)" "unprognostic (8.87e-2)" "unprognostic (2.72e-2)" "unprognostic (1.18e-1)" "unprognostic (5.98e-2)" "unprognostic (2.37e-3)" "unprognostic (6.13e-2)" "unprognostic (1.33e-1)" "unprognostic (1.11e-4)" 0.2 2.6 2.5 0.2 32.3 0.0 0.1 0.0 14.4 2.3 0.0 1.4 0.0 3.3 0.0 0.5 1.6 0.3 0.4 9.2 11.9 1.1 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.7 0.0 0.0 0.2 0.5 2.0 0.0 0.1 0.3 0.0 0.5 1.4 0.0 0.0 0.6 0.1 0.9 0.1 0.1 1.4 0.0 0.5 0.3 0.0 0.0 0.0 1.2 0.0 0.0 0.1 0.0 0.0 0.5 0.0 0.1 0.0 0.0 0.0 0.0 2.6 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 1.3 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.0 0.0 3.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 32.3 0.0 14.4 9.2 11.9 0.0 0.0 0.0 0.0 0.9 0.0 0.4 0.0 0.0 70.5 0.0 0.1 0.3 0.0 0.0 26.4 0.0 0.0 1.6 0.0 1.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.6 0.2 5.3 0.7 0.0 0.0 937.7 0.0 0.0 0.5 0.0 0.1 0.0 0.1 0.0 0.5 0.1 0.0 576.6 0.0 0.0 0.0 0.5 1.9 1.2 0.1 1.8 43.1 0.0 0.1 0.0 254.3 17.3 0.0 0.0 0.0 0.0 0.2 0.0 2.0 0.0 1.6 6.6 0.5 4.9 0.2 0.5 0.1 0.4 0.0 0.1 0.1 0.0 0.3 DGKD "DGKdelta, KIAA0145" ENSG00000077044 "Diacylglycerol kinase delta" Q16760 2 233354494-233472104 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Endocytosis, Protein transport, Transport" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 30.4" "Cell type enhanced" "Detected in many" "Gastric mucus-secreting cells: 143.2;Inhibitory neurons: 137.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HDLM-2: 17.3;HeLa: 21.8;U-698: 22.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027530, HPA049101" Approved Supported Cytosol NA NA "Cluster 37: B-cells - Transcription" "Cluster 59: Non-specific - Translation" "Cluster 20: HeLa - Mitochondria" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Cytosol "HPA027530: AB_2672320, HPA049101: AB_2680630" "unprognostic (1.84e-1)" "unprognostic (2.19e-2)" "unprognostic (7.76e-3)" "unprognostic (1.92e-2)" "unprognostic (5.69e-2)" "unprognostic (6.24e-2)" "prognostic unfavorable (1.69e-5)" "unprognostic (2.25e-1)" "unprognostic (1.17e-3)" "unprognostic (6.03e-2)" "unprognostic (5.76e-2)" "unprognostic (1.00e-1)" "prognostic unfavorable (4.07e-8)" "unprognostic (1.78e-1)" "unprognostic (7.18e-2)" "unprognostic (1.22e-1)" "unprognostic (5.94e-3)" 5.2 3.4 4.3 1.9 5.5 12.0 5.9 20.5 6.2 4.5 3.2 9.0 1.6 5.9 1.6 2.2 5.7 1.0 7.6 5.8 4.0 2.5 3.6 10.6 4.3 6.5 3.9 8.9 2.7 0.4 3.7 2.9 7.4 5.7 2.3 5.4 5.9 0.5 30.4 3.0 12.9 0.7 4.1 11.4 25.2 9.6 4.4 1.0 8.3 0.9 4.5 5.3 2.6 8.8 1.7 8.5 2.1 1.5 1.5 1.4 3.0 2.4 1.0 0.6 0.5 9.7 1.9 10.3 1.1 2.4 4.5 2.0 2.4 1.0 3.2 17.3 11.3 4.7 21.8 5.8 0.9 11.7 7.2 2.3 2.2 1.1 2.1 1.8 0.8 2.1 7.8 1.8 1.6 3.1 9.2 3.3 1.6 2.8 6.9 14.5 5.7 1.6 0.9 3.3 2.1 2.2 1.4 2.3 1.0 1.8 0.6 5.2 1.0 1.2 3.0 1.2 1.7 7.1 6.2 22.7 0.8 5.6 0.6 1.7 1.6 5.6 2.1 0.6 1.1 4.8 0.5 1.5 0.4 5.0 1.7 2.4 1.2 0.6 1.0 0.4 0.2 1.7 4.3 5.5 20.5 6.2 5.8 4.0 6.5 3.9 7.4 4.1 4.4 8.8 18.9 32.1 46.2 27.1 61.1 8.9 6.4 5.6 4.6 33.8 19.6 11.6 21.0 0.0 13.8 0.0 62.6 14.6 62.0 40.6 0.0 3.6 14.9 23.4 12.5 19.1 2.4 5.0 11.1 4.4 1.2 9.7 143.2 38.1 5.7 13.1 4.6 7.0 6.8 8.4 137.9 32.8 8.2 10.4 13.8 38.7 6.5 28.7 8.8 11.2 17.5 13.9 49.4 43.2 81.5 26.0 13.5 4.5 34.7 17.6 29.6 2.6 4.8 44.3 19.7 49.4 21.2 14.4 29.3 4.5 3.7 2.5 32.5 7.6 20.1 9.9 DGKE "DAGK6, DGK" ENSG00000153933 "Diacylglycerol kinase epsilon" P52429 17 56834107-56869567 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Transferase" "Disease variant, Hemolytic uremic syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "retina: 34.5" "Cell type enhanced" "Detected in many" "Bipolar cells: 181.1;Cone photoreceptor cells: 189.7;Inhibitory neurons: 90.0;Rod photoreceptor cells: 165.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "Karpas-707: 84.8;MOLT-4: 30.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017167 Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 35: T-regs - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 2: Karpas-707 - Immune response" "Cluster 56: Bipolar cells - Visual perception" "Nucleoplasm, Cytosol" "HPA017167: AB_1847638" "unprognostic (1.19e-2)" "unprognostic (2.11e-2)" "unprognostic (2.69e-1)" "prognostic favorable (3.92e-5)" "unprognostic (4.20e-2)" "unprognostic (4.87e-2)" "unprognostic (3.37e-1)" "unprognostic (4.27e-2)" "unprognostic (1.19e-3)" "unprognostic (4.75e-2)" "unprognostic (6.07e-3)" "unprognostic (2.68e-1)" "unprognostic (2.55e-2)" "unprognostic (1.99e-1)" "unprognostic (2.17e-1)" "unprognostic (1.26e-1)" "unprognostic (3.69e-3)" 4.1 2.2 5.4 4.5 6.9 3.1 3.0 9.4 7.4 4.9 7.7 4.9 2.6 6.5 4.2 2.6 4.8 4.6 2.9 5.8 8.1 2.6 2.8 5.2 5.0 3.3 4.7 3.5 3.9 4.1 6.2 2.7 3.4 4.1 3.3 34.5 2.5 3.3 1.2 1.9 4.4 4.3 2.7 6.9 3.7 6.5 6.9 9.8 4.0 2.2 4.3 3.8 4.2 5.8 3.5 3.3 3.0 0.3 0.6 1.0 1.4 5.8 4.7 3.9 4.5 7.7 4.2 5.1 7.0 3.1 1.9 4.2 7.2 3.2 7.8 16.5 9.5 6.6 8.9 5.1 3.3 12.7 8.9 1.9 4.0 4.1 8.0 3.6 5.4 14.7 5.5 84.8 4.8 5.1 30.3 7.1 2.3 4.6 10.0 9.4 12.4 12.2 3.9 7.6 4.7 3.2 4.7 2.5 0.2 1.9 5.3 6.0 5.0 1.1 5.4 1.7 0.9 11.3 25.3 3.4 3.3 7.3 0.3 0.1 0.2 0.0 1.0 0.1 0.7 0.9 0.6 0.7 0.2 0.3 0.7 0.9 0.3 0.7 0.2 0.8 1.7 0.3 5.4 6.9 9.4 7.4 5.8 8.1 3.3 4.7 3.4 2.7 6.9 5.8 51.2 3.2 6.0 10.4 11.3 8.9 13.5 3.1 21.6 181.1 5.0 6.3 6.3 10.0 4.0 16.5 189.7 6.6 16.3 5.6 0.0 7.4 18.3 9.0 9.9 30.6 11.3 2.1 66.0 4.7 3.0 6.9 9.7 19.3 0.0 13.1 29.3 4.0 2.2 8.4 90.0 7.7 8.2 5.0 9.3 9.2 4.4 7.4 3.6 32.8 6.3 18.6 14.4 32.6 14.4 6.0 6.4 5.3 15.1 21.3 1.9 0.1 2.8 165.4 6.6 11.8 10.7 28.5 20.7 9.7 6.7 3.4 18.9 5.7 5.8 13.4 DGKG DAGK3 ENSG00000058866 "Diacylglycerol kinase gamma" P49619 3 186105668-186362234 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 28.2" "Cell type enhanced" "Detected in many" "Astrocytes: 223.0;Excitatory neurons: 111.0;Inhibitory neurons: 63.5;Oligodendrocyte precursor cells: 334.8" "Cancer enhanced" "Detected in some" "glioma: 2.8" "Low region specificity" "Detected in many" "Group enriched" "Detected in many" 5 "classical monocyte: 2.1;eosinophil: 1.2;intermediate monocyte: 1.2;myeloid DC: 1.5;neutrophil: 2.6;non-classical monocyte: 1.5" "Group enriched" "Detected in many" 7 "dendritic cells: 1.5;granulocytes: 2.6;monocytes: 2.1" "Cell line enhanced" "Detected in some" "HDLM-2: 23.9;HL-60: 7.7;U-266/84: 9.4;U-87 MG: 14.3;U-937: 7.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036577 Approved Supported "Vesicles,Plasma membrane" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 6: Brain - Smell perception" "Cluster 44: HDLM-2 - Immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Vesicles, Plasma membrane" "HPA036577: AB_10672358" "unprognostic (2.23e-1)" "unprognostic (1.97e-1)" "unprognostic (1.56e-2)" "unprognostic (3.24e-5)" "unprognostic (2.70e-1)" "unprognostic (6.09e-4)" "unprognostic (1.21e-3)" "unprognostic (3.80e-2)" "unprognostic (5.88e-2)" "unprognostic (1.50e-1)" "unprognostic (1.94e-1)" "unprognostic (5.09e-2)" "unprognostic (8.05e-7)" "unprognostic (3.47e-3)" "unprognostic (7.19e-2)" "unprognostic (1.41e-1)" "unprognostic (9.16e-3)" 1.6 4.2 14.2 0.8 17.4 9.3 1.1 28.2 11.9 2.2 0.0 3.2 1.4 1.2 8.0 4.6 4.1 0.9 9.1 20.4 3.6 1.3 0.8 3.8 0.9 20.1 6.5 1.2 0.5 5.7 6.0 7.8 20.8 1.3 0.8 1.7 0.8 1.8 1.8 0.8 1.7 2.4 0.6 0.9 2.1 0.3 9.6 0.5 1.8 1.0 0.8 3.4 1.7 13.2 3.2 4.8 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.0 2.7 0.0 3.3 0.2 0.0 0.0 0.0 23.9 0.0 3.2 0.0 3.5 0.0 7.7 0.3 0.0 0.0 1.4 0.0 0.1 0.0 0.6 0.0 0.4 0.4 0.1 0.1 2.6 0.4 0.0 1.4 1.7 0.0 2.6 0.0 0.0 0.6 0.0 0.9 0.0 2.0 0.0 0.1 4.9 0.0 0.0 0.8 2.4 2.9 0.0 9.4 0.0 14.3 7.0 2.6 0.0 2.1 1.2 0.0 1.2 0.0 0.3 0.0 0.0 1.5 0.1 0.0 0.0 2.6 0.0 1.5 0.2 0.0 0.7 14.2 17.4 28.2 11.9 20.4 3.6 20.1 6.5 20.8 0.6 9.6 13.2 0.1 0.0 1.7 223.0 3.1 0.4 0.2 0.0 0.6 0.1 0.1 0.4 19.4 1.5 0.0 1.8 0.0 0.1 0.0 0.0 0.0 1.4 2.6 0.3 0.1 5.0 0.0 0.4 111.0 1.2 0.0 0.5 0.5 0.1 0.0 0.3 22.1 0.0 2.1 1.7 63.5 0.1 0.0 3.2 1.4 4.2 1.8 3.4 0.0 12.2 5.2 6.8 0.0 334.8 7.8 1.0 0.1 0.4 0.2 0.4 0.1 0.9 0.0 0.1 13.1 1.8 14.5 0.0 0.2 0.4 0.4 0.1 0.1 0.9 0.1 0.4 DGKH DGKeta ENSG00000102780 "Diacylglycerol kinase eta" Q86XP1 13 42040036-42256578 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 25.8" "Cell type enhanced" "Detected in all" "Prostatic glandular cells: 137.8;Urothelial cells: 147.3" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in many" "basal ganglia: 25.8" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039533, HPA040355, HPA061538" Uncertain Supported "Vesicles,Plasma membrane" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 10: Brain - Neuronal signaling" "Cluster 15: RT4 - Unknown function" "Cluster 44: Endometrium - Transcription" "Plasma membrane" Vesicles "HPA039533: AB_10795145, HPA040355: AB_10796452, HPA061538: " "unprognostic (2.80e-1)" "unprognostic (7.03e-2)" "unprognostic (1.30e-1)" "unprognostic (5.69e-2)" "unprognostic (1.55e-3)" "unprognostic (7.62e-2)" "unprognostic (1.04e-2)" "unprognostic (9.60e-2)" "unprognostic (7.00e-3)" "unprognostic (4.37e-2)" "unprognostic (1.86e-1)" "unprognostic (2.41e-1)" "unprognostic (3.43e-3)" "unprognostic (1.03e-1)" "unprognostic (1.67e-1)" "unprognostic (4.93e-2)" "unprognostic (1.43e-2)" 3.7 1.3 4.5 2.0 25.8 1.3 3.5 8.7 5.4 4.4 0.0 3.7 1.5 6.4 6.9 4.1 4.3 2.5 3.0 7.3 4.4 3.3 1.0 7.8 2.2 0.0 7.4 2.8 1.0 0.7 2.6 4.5 0.4 2.8 3.3 2.6 3.0 2.1 1.5 3.2 2.7 4.0 0.2 1.7 2.6 2.3 9.7 2.7 2.5 2.2 1.3 5.3 4.6 2.8 5.6 6.6 4.3 3.6 1.9 4.2 0.5 3.4 2.7 2.2 2.8 0.6 4.7 4.3 4.1 3.7 8.3 11.8 3.8 7.7 3.3 3.4 12.4 7.6 3.6 0.4 2.4 3.3 2.0 1.6 7.7 4.3 17.0 3.4 9.9 5.3 3.0 2.9 3.8 5.1 3.4 1.7 1.9 5.2 4.3 5.0 3.8 2.9 7.4 16.7 2.5 2.6 3.1 4.0 3.0 1.8 3.4 8.9 9.8 4.1 3.8 4.5 4.7 1.5 1.5 4.8 2.4 2.9 3.1 0.6 0.3 0.1 0.2 0.2 0.2 0.1 0.4 0.4 0.0 0.2 0.2 0.4 0.9 0.1 0.1 0.3 0.3 0.1 4.5 25.8 8.7 5.4 7.3 4.4 0.0 7.4 0.4 0.2 9.7 2.8 64.8 22.4 20.1 8.8 1.9 61.7 58.1 61.1 15.9 44.5 13.6 8.9 8.5 24.3 44.7 11.0 4.2 3.7 2.2 29.0 1.9 11.3 25.9 64.1 26.0 50.8 47.4 2.7 85.4 7.2 2.2 17.5 15.3 46.2 7.6 5.7 23.2 3.2 6.8 1.7 60.2 18.7 14.2 5.6 43.1 20.1 3.4 8.0 8.8 56.2 8.6 18.8 1.0 54.3 11.0 27.6 19.2 9.1 6.2 137.8 13.1 8.4 91.8 2.6 26.3 16.2 54.1 3.8 3.8 19.7 33.1 2.9 13.0 11.5 22.0 147.3 DGKI DGK-IOTA ENSG00000157680 "Diacylglycerol kinase iota" O75912 7 137381037-137847092 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "brain: 19.2;choroid plexus: 9.2;retina: 6.5;thyroid gland: 15.6" "Group enriched" "Detected in some" 5 "Excitatory neurons: 606.4;Inhibitory neurons: 414.6;Oligodendrocyte precursor cells: 329.2" "Group enriched" "Detected in some" 4 "glioma: 0.8;melanoma: 0.6;renal cancer: 1.0;thyroid cancer: 1.5" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BJ: 3.0;GAMG: 3.6;hTEC/SVTERT24-B: 3.2;SCLC-21H: 5.0;U-2197: 14.1;U-87 MG: 5.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 58: Brain - Synaptic function" "Cluster 18: U-2197 - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "unprognostic (1.76e-1)" "unprognostic (1.22e-1)" "unprognostic (6.66e-3)" "unprognostic (1.76e-1)" "unprognostic (6.08e-2)" "unprognostic (1.42e-1)" "unprognostic (9.62e-2)" "unprognostic (2.23e-1)" "unprognostic (1.09e-1)" "unprognostic (9.01e-2)" "unprognostic (8.74e-2)" "unprognostic (4.46e-2)" "unprognostic (5.98e-5)" "unprognostic (2.85e-3)" "unprognostic (1.85e-1)" "unprognostic (1.26e-2)" "unprognostic (1.73e-3)" 0.5 0.3 4.5 0.2 19.2 0.0 0.2 1.0 11.8 0.1 9.2 0.3 0.0 0.3 0.1 0.0 0.1 0.6 2.8 6.1 2.9 0.5 0.0 0.0 0.0 0.1 4.7 0.0 0.0 0.2 1.3 0.0 1.5 0.1 0.1 6.5 0.3 0.1 0.0 0.1 0.1 1.3 0.0 0.0 0.1 0.6 6.5 0.0 15.6 0.0 0.0 0.2 0.0 8.2 0.0 0.0 0.4 0.0 0.8 0.6 0.0 3.0 0.2 0.1 0.3 0.0 0.0 0.0 0.0 0.9 3.6 0.0 0.0 0.0 0.5 0.0 0.0 0.1 0.1 0.0 0.9 0.0 0.1 0.2 0.0 3.2 0.0 0.5 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.0 2.3 0.0 0.0 0.5 0.2 0.0 0.0 0.1 1.3 0.5 14.1 0.6 0.1 0.0 0.0 5.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.5 19.2 1.0 11.8 6.1 2.9 0.1 4.7 1.5 0.0 6.5 8.2 0.3 0.0 0.0 7.5 0.3 1.1 0.2 1.4 0.6 53.1 1.0 0.1 11.3 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.3 0.4 1.3 1.1 0.0 0.0 606.4 0.0 0.0 2.1 0.0 0.3 0.0 0.1 0.4 0.0 0.6 45.4 414.6 0.0 44.7 0.0 0.7 3.6 0.9 0.2 0.0 60.9 0.0 2.1 1.0 329.2 84.4 0.0 0.0 1.5 0.0 0.2 0.0 0.3 0.2 3.3 0.0 0.8 2.2 0.2 0.5 0.2 0.6 0.0 0.1 0.5 0.0 0.0 DGKK ENSG00000274588 "Diacylglycerol kinase kappa" Q5KSL6 X 50365409-50470825 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 29 "adrenal gland: 3.4;brain: 12.2;pituitary gland: 6.1" "Cell type enriched" "Detected in some" 6 "NK-cells: 13.4" "Not detected" "Not detected" "Region enhanced" "Detected in many" "thalamus: 12.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 21 "Hep G2: 34.5" "Region enhanced" "Detected in many" "hypothalamus: 19.8" "Low region specificity" "Detected in some" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 63: NK-cells & T-cells - Immune response" "unprognostic (3.99e-1)" "unprognostic (1.18e-1)" "unprognostic (4.18e-3)" "unprognostic (1.23e-1)" "unprognostic (5.83e-3)" "unprognostic (9.58e-2)" "unprognostic (2.41e-2)" "unprognostic (1.62e-2)" "unprognostic (2.06e-1)" "unprognostic (4.28e-3)" "unprognostic (3.89e-2)" "unprognostic (1.20e-1)" "unprognostic (9.49e-2)" "unprognostic (4.64e-3)" 0.0 3.4 1.3 0.0 5.1 0.1 0.0 0.0 2.9 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 4.5 0.0 0.0 0.0 0.0 0.8 2.3 0.0 0.0 0.0 6.1 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.2 12.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 34.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.3 5.1 0.0 2.9 0.1 4.5 0.8 2.3 1.1 0.4 12.2 0.2 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 1.0 0.1 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 1.0 0.1 0.0 13.4 2.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.1 DGKQ "DAGK, DAGK4, DAGK7" ENSG00000145214 "Diacylglycerol kinase theta" P52824 4 958887-986895 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 33.5;Intestinal goblet cells: 21.6;Paneth cells: 33.1;Proximal enterocytes: 29.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026797, CAB033835" Uncertain NA NA "Cluster 34: Basophils - Unknown function" "Cluster 45: Intestine - Brush border" "Cluster 24: NB-4 - Immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "CAB033835: AB_2091307, HPA026797: AB_10600902" "unprognostic (7.39e-2)" "unprognostic (1.66e-1)" "unprognostic (1.76e-1)" "unprognostic (2.64e-2)" "unprognostic (1.14e-1)" "unprognostic (5.08e-2)" "unprognostic (3.37e-1)" "unprognostic (6.39e-2)" "unprognostic (2.90e-2)" "unprognostic (1.06e-1)" "unprognostic (6.45e-2)" "unprognostic (1.06e-2)" "unprognostic (9.77e-2)" "unprognostic (3.08e-3)" "unprognostic (4.38e-2)" "unprognostic (2.65e-2)" "unprognostic (1.65e-3)" 6.5 8.2 11.7 9.2 11.4 9.8 6.7 15.4 15.8 9.0 3.6 20.0 22.2 7.9 2.6 10.8 7.6 5.1 6.0 14.0 10.9 8.3 8.1 9.5 11.0 14.3 8.6 6.5 9.9 3.7 10.5 3.2 10.1 9.3 6.5 1.0 9.4 4.0 3.6 13.2 23.6 2.7 6.1 15.4 8.4 9.0 11.8 7.5 8.7 1.3 4.4 8.4 9.7 7.0 5.7 9.1 3.9 13.2 4.7 3.8 14.5 10.7 6.0 6.0 5.9 6.5 11.1 7.6 8.8 6.8 12.2 6.5 2.2 7.5 1.4 6.0 6.9 11.8 10.3 11.6 8.0 5.1 15.2 7.2 12.5 4.9 2.3 5.1 7.3 15.6 9.1 0.9 4.7 8.6 10.7 29.6 6.9 15.9 15.3 17.0 1.1 0.9 6.5 7.9 2.4 6.6 3.7 4.1 11.3 3.0 9.9 12.3 10.8 10.3 4.8 11.7 7.2 20.2 9.4 6.0 8.9 10.9 9.5 2.9 0.5 1.3 2.0 0.5 0.9 0.5 0.7 1.7 0.4 0.4 0.7 1.3 0.3 2.4 0.4 0.8 0.5 0.8 11.7 11.4 15.4 15.8 14.0 10.9 14.3 8.6 10.1 6.1 11.8 7.0 4.3 3.2 3.1 8.5 3.6 2.8 1.3 2.9 1.2 3.6 3.5 3.9 3.0 4.3 2.9 3.7 4.2 0.5 15.1 33.5 0.0 3.0 0.6 2.6 3.3 3.3 7.7 5.7 12.4 4.9 2.1 2.9 3.1 4.1 0.0 6.2 2.5 5.8 2.5 3.3 11.8 21.6 0.0 4.1 2.3 1.3 4.1 4.6 3.6 5.6 4.5 3.0 10.3 3.0 3.2 5.7 33.1 2.6 4.6 3.1 29.1 0.9 4.4 1.0 0.0 2.6 2.8 3.2 4.3 2.9 3.8 0.7 6.7 3.6 14.5 3.8 DGKZ "DAGK5, DAGK6, DGK-ZETA, hDGKzeta" ENSG00000149091 "Diacylglycerol kinase zeta" Q13574 11 46332905-46380554 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 146.2" "Cell type enhanced" "Detected in all" "NK-cells: 129.8" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in many" 27 "amygdala: 46.5;basal ganglia: 75.1;cerebral cortex: 146.2;hippocampal formation: 133.8;white matter: 51.0" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA051336 Enhanced Supported Supported "Nuclear speckles" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 10: Brain - Neuronal signaling" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 63: NK-cells & T-cells - Immune response" "Nuclear speckles" "HPA051336: AB_2681448" "unprognostic (2.85e-2)" "unprognostic (3.90e-2)" "unprognostic (2.39e-1)" "unprognostic (1.65e-1)" "unprognostic (1.40e-1)" "unprognostic (4.12e-2)" "unprognostic (3.08e-3)" "unprognostic (1.31e-1)" "unprognostic (1.03e-2)" "unprognostic (2.49e-2)" "unprognostic (3.66e-3)" "unprognostic (8.18e-2)" "prognostic unfavorable (4.74e-5)" "unprognostic (1.48e-3)" "unprognostic (7.75e-2)" "unprognostic (3.61e-2)" "unprognostic (7.84e-3)" 20.7 14.2 46.5 21.6 75.1 54.6 19.4 3.3 146.2 16.5 0.0 20.3 36.4 16.8 4.0 19.5 15.3 11.1 46.5 133.8 0.0 18.3 10.5 18.3 39.9 0.0 0.0 12.4 31.5 10.0 58.7 14.1 0.0 18.6 6.6 2.5 43.4 10.7 95.7 22.3 41.2 9.1 0.0 36.1 22.2 15.4 1.4 34.0 12.5 25.1 17.1 18.2 15.3 51.0 38.1 33.2 22.1 33.2 11.5 12.8 102.1 29.0 21.5 30.0 26.3 39.8 17.1 48.4 20.5 30.1 33.0 43.3 26.7 42.0 10.6 48.8 62.5 31.7 25.2 29.5 20.5 60.5 61.2 17.3 19.3 16.5 22.2 15.3 33.4 39.3 45.1 29.1 21.5 99.8 58.6 94.3 64.3 54.5 50.3 69.0 38.2 20.6 9.1 36.6 150.3 25.6 33.2 109.6 23.0 13.8 78.8 75.2 37.9 39.2 42.4 62.6 52.9 19.1 23.4 40.3 53.8 54.0 37.2 12.4 13.5 6.0 6.8 5.6 4.1 0.3 4.3 5.9 12.0 0.8 4.3 4.6 9.5 7.6 6.4 5.7 4.4 10.5 46.5 75.1 3.3 146.2 133.8 0.0 0.0 0.0 0.0 0.0 1.4 51.0 46.0 3.2 6.6 44.7 16.4 13.3 22.3 16.3 14.2 27.6 24.6 19.8 24.4 8.6 8.7 9.2 20.9 14.6 95.8 37.7 9.8 13.2 6.1 9.9 15.2 34.2 51.5 23.4 114.0 47.8 105.1 12.4 34.1 14.1 21.0 25.7 56.7 7.1 51.2 16.8 45.0 26.3 22.4 46.1 26.9 11.4 13.1 34.0 12.4 31.9 50.6 6.4 129.8 8.5 24.7 33.5 41.0 8.2 25.3 16.6 97.0 20.2 8.2 9.9 32.9 17.8 16.8 7.0 12.2 12.3 9.2 27.4 71.8 19.4 29.9 17.2 DGUOK dGK ENSG00000114956 "Deoxyguanosine kinase" Q16854 2 73926826-73958961 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Transferase" "Disease variant, Neuropathy, Primary mitochondrial disease, Progressive external ophthalmoplegia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034766, HPA057246" Approved NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "HPA034766: AB_10669850, HPA057246: AB_2683381" "unprognostic (3.40e-1)" "unprognostic (2.43e-1)" "unprognostic (1.45e-2)" "unprognostic (2.94e-2)" "unprognostic (1.20e-1)" "unprognostic (4.17e-2)" "unprognostic (2.14e-2)" "unprognostic (1.37e-2)" "unprognostic (4.10e-3)" "unprognostic (5.07e-2)" "unprognostic (1.41e-1)" "unprognostic (9.84e-2)" "prognostic unfavorable (8.69e-7)" "unprognostic (3.86e-1)" "unprognostic (2.21e-2)" "unprognostic (5.98e-2)" "prognostic favorable (7.47e-4)" 20.8 30.0 37.1 20.3 39.2 27.1 28.1 36.5 48.4 23.0 36.8 25.0 17.7 23.1 34.4 21.8 31.3 19.4 23.0 38.5 42.8 24.6 30.5 17.7 36.8 37.9 37.7 30.0 16.3 11.0 41.3 21.5 39.1 24.5 29.1 34.5 19.8 22.5 17.1 26.5 20.2 21.9 37.9 25.9 21.0 32.8 38.8 36.3 22.6 17.7 40.9 22.2 20.9 38.8 45.1 72.5 74.4 67.9 47.8 53.8 37.1 29.3 56.0 66.7 61.1 91.2 51.5 83.0 27.4 42.1 74.1 34.7 85.4 57.1 79.3 47.1 53.6 65.8 25.4 107.5 70.5 62.1 66.0 49.7 51.3 50.4 58.9 48.6 48.3 91.4 67.2 37.0 78.8 54.4 59.6 101.2 76.7 60.5 53.9 73.8 73.1 59.7 55.8 49.6 85.0 82.6 27.9 28.2 77.1 35.5 34.0 34.8 45.3 43.3 68.8 37.8 52.6 32.3 31.4 86.1 62.2 65.9 95.1 129.8 70.9 138.7 62.3 87.3 72.4 108.5 77.0 69.6 81.6 114.5 98.6 79.6 56.4 79.4 84.7 91.3 79.9 91.3 37.1 39.2 36.5 48.4 38.5 42.8 37.9 37.7 39.1 37.9 38.8 38.8 72.5 32.1 42.8 14.7 103.4 74.2 138.7 249.6 88.2 52.3 85.0 128.1 19.1 78.6 108.6 60.7 6.2 159.4 89.7 58.9 84.1 102.6 12.3 82.3 69.1 74.1 113.1 67.1 17.5 149.1 165.4 88.3 40.2 82.6 57.6 87.4 76.1 69.9 90.9 52.2 21.1 100.1 158.7 88.3 112.3 15.1 93.5 80.2 110.3 15.9 151.9 89.5 118.4 12.5 27.2 173.0 88.1 86.9 70.2 146.2 88.2 119.7 87.2 40.4 92.1 55.3 89.3 105.3 129.4 88.3 83.3 124.5 101.4 124.5 104.9 142.9 DHDDS "DS, FLJ13102, hCIT, HDS, RP59" ENSG00000117682 "Dehydrodolichyl diphosphate synthase subunit" Q86SQ9 1 26432282-26471306 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Lipid metabolism" Transferase "Disease variant, Epilepsy, Mental retardation, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 256.5;Early spermatids: 99.1;Rod photoreceptor cells: 106.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026721, HPA026727" Uncertain Uncertain "Plasma membrane" NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 24: Salivary gland - Salivary secretion" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 9: Photoreceptor cells - Phototransduction" "Plasma membrane" "HPA026721: AB_1847643, HPA026727: AB_1847644" "unprognostic (1.11e-2)" "unprognostic (5.43e-2)" "unprognostic (5.12e-2)" "unprognostic (9.81e-2)" "unprognostic (6.71e-2)" "unprognostic (7.23e-2)" "unprognostic (1.32e-3)" "unprognostic (3.81e-3)" "unprognostic (2.40e-1)" "unprognostic (5.42e-2)" "unprognostic (4.51e-2)" "unprognostic (3.40e-2)" "prognostic favorable (4.08e-7)" "unprognostic (9.42e-2)" "unprognostic (2.85e-1)" "unprognostic (2.22e-1)" "unprognostic (2.95e-1)" 57.3 19.6 12.3 18.9 11.8 12.4 22.7 32.5 14.0 14.6 14.6 37.3 19.1 13.5 38.5 26.3 12.9 15.9 19.8 12.8 13.3 25.5 22.0 13.9 17.6 15.5 16.9 11.4 18.5 39.8 20.9 12.6 18.8 14.1 38.8 37.8 43.3 14.0 13.5 21.2 18.2 18.4 9.0 14.1 23.3 12.3 14.1 14.1 19.1 11.8 20.8 18.1 14.4 12.2 34.2 24.8 20.6 23.8 36.1 28.2 28.4 54.9 33.4 44.0 41.6 37.4 34.6 38.4 33.3 57.2 30.0 24.1 25.4 42.8 42.9 22.7 13.9 38.0 66.9 30.8 39.3 41.4 51.5 40.3 27.6 59.1 32.2 29.4 51.2 26.7 27.3 41.0 39.7 19.4 23.1 20.2 26.3 53.1 36.2 25.3 33.4 31.2 25.4 28.8 24.4 19.4 36.4 38.0 26.6 26.8 29.8 20.9 63.0 30.1 26.3 60.4 32.0 48.1 72.4 39.5 43.0 54.0 26.8 9.4 16.1 9.6 13.8 23.6 9.8 13.2 9.0 9.1 13.6 10.2 7.4 10.9 13.0 10.1 23.1 11.5 8.3 10.5 12.3 11.8 32.5 14.0 12.8 13.3 15.5 16.9 18.8 9.0 14.1 12.2 9.4 9.6 7.8 7.8 13.5 4.6 9.6 12.0 10.8 29.6 9.6 7.4 15.5 15.7 13.8 14.7 256.5 18.3 13.7 76.3 11.7 19.3 99.1 11.6 12.9 11.1 20.9 5.7 26.9 14.5 23.4 11.1 33.6 20.0 19.0 14.4 10.0 13.2 24.5 15.2 28.5 46.3 14.2 11.5 7.1 23.4 10.5 10.5 10.6 10.3 34.4 16.3 14.4 9.0 11.4 17.6 40.3 7.5 18.7 10.6 24.7 29.3 11.5 106.1 0.0 8.4 14.5 13.2 13.5 12.4 5.1 25.4 10.3 15.8 26.0 12.2 DHPS MIG13 ENSG00000095059 "Deoxyhypusine synthase" P49366 19 12675717-12681880 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hypusine biosynthesis" Transferase "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA014461, HPA029413" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 54: Non-specific - Microtubule organization" "Cluster 29: U-266 - Adaptive immune response" "Cluster 39: Non-specific - Basic cellular processes" "Nucleoplasm, Cytosol" "HPA014461: AB_1847651, HPA029413: AB_10602217" "unprognostic (4.17e-2)" "unprognostic (2.55e-2)" "unprognostic (2.05e-2)" "unprognostic (2.61e-1)" "unprognostic (3.10e-1)" "unprognostic (1.01e-2)" "unprognostic (3.06e-1)" "unprognostic (2.42e-1)" "unprognostic (1.85e-1)" "unprognostic (3.59e-2)" "unprognostic (1.20e-2)" "unprognostic (4.85e-2)" "unprognostic (3.05e-2)" "unprognostic (2.46e-3)" "unprognostic (1.32e-1)" "unprognostic (1.56e-1)" "unprognostic (8.83e-2)" 30.6 43.2 44.6 23.9 48.1 21.7 29.6 51.0 57.5 35.7 50.0 40.9 28.0 33.2 15.6 29.5 38.6 20.1 41.0 46.5 48.6 34.2 41.0 29.6 32.7 46.4 45.1 40.6 49.7 47.0 52.8 19.7 50.0 34.8 29.5 69.1 34.1 27.9 92.6 41.3 32.8 29.1 47.7 31.6 44.2 16.0 45.9 45.2 28.7 70.5 34.7 36.7 33.1 56.2 70.8 50.8 80.8 41.5 34.2 57.7 18.6 44.0 64.9 82.8 82.9 35.4 33.8 71.7 49.4 48.2 75.6 41.0 55.7 63.0 57.4 64.2 37.8 48.8 51.4 47.1 43.8 57.2 72.1 47.2 74.8 49.7 85.2 82.9 59.1 141.5 45.1 49.5 61.5 137.0 105.1 83.3 64.2 90.3 85.1 65.8 29.1 106.6 63.5 34.6 106.7 144.4 44.0 64.2 76.0 48.1 59.0 96.5 29.8 94.4 38.2 93.5 69.2 160.0 184.9 49.9 59.7 66.2 94.5 37.0 58.8 82.7 51.0 54.1 53.0 86.2 59.0 52.8 63.4 82.1 77.7 56.8 18.2 64.2 72.8 64.9 77.6 70.0 44.6 48.1 51.0 57.5 46.5 48.6 46.4 45.1 50.0 47.7 45.9 56.2 40.3 41.7 30.7 10.1 54.8 55.6 79.2 93.0 38.7 75.8 48.3 64.5 8.6 37.1 49.1 33.1 45.9 47.1 52.2 35.2 86.1 53.7 20.9 38.2 24.5 35.0 41.3 26.7 11.9 37.6 55.1 35.0 33.6 27.9 24.1 46.0 30.4 34.6 42.8 42.1 12.5 60.8 79.3 37.6 42.5 27.5 45.1 35.3 49.8 6.5 62.7 115.2 53.5 8.0 14.7 48.7 70.1 34.6 51.1 73.3 87.9 84.1 49.6 129.2 46.0 39.6 53.8 33.3 62.3 39.7 51.0 71.8 51.1 37.4 54.3 71.0 DIMT1 "DIMT1L, HSA9761" ENSG00000086189 "DIMT1 rRNA methyltransferase and ribosome maturation factor" Q9UNQ2 5 62347284-62403943 "Enzymes, Predicted intracellular proteins" "rRNA processing" "Methyltransferase, RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Prostatic glandular cells: 104.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA042944 Approved Supported "Nucleoplasm,Nucleoli,Nucleoli rim,Cytosol" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 46: Fibroblasts - ECM organization" "Cluster 25: RPMI-8226 - Immune response" "Cluster 22: Epithelial cell types - Mixed function" "Nucleoli, Nucleoli rim" "Nucleoplasm, Cytosol" "HPA042944: AB_2678234" "unprognostic (1.58e-1)" "unprognostic (2.27e-1)" "unprognostic (6.02e-3)" "unprognostic (7.16e-2)" "unprognostic (8.95e-3)" "unprognostic (1.73e-2)" "prognostic unfavorable (6.93e-4)" "unprognostic (8.88e-2)" "unprognostic (1.18e-2)" "unprognostic (1.62e-1)" "unprognostic (5.31e-2)" "unprognostic (3.70e-1)" "prognostic unfavorable (8.90e-12)" "unprognostic (8.89e-2)" "unprognostic (2.89e-1)" "unprognostic (1.49e-1)" "unprognostic (5.15e-2)" 16.3 13.6 6.5 13.3 6.5 9.1 19.7 6.7 9.6 17.2 6.4 10.9 8.5 14.6 13.9 17.5 14.5 14.2 17.7 6.6 6.8 10.6 15.4 9.8 15.9 6.7 6.7 15.5 19.3 13.3 10.3 17.3 6.7 15.9 12.0 2.9 15.2 16.2 9.7 8.5 8.8 21.0 6.7 13.3 8.5 8.2 6.6 15.0 13.4 12.8 16.8 26.0 11.4 6.7 33.1 19.9 24.2 44.1 37.7 57.4 35.0 57.3 33.7 57.3 55.8 45.1 36.3 61.4 48.4 61.9 45.4 20.2 38.7 35.8 61.3 46.4 34.0 27.2 15.0 33.8 48.1 32.4 34.7 46.7 31.1 54.1 57.3 28.1 46.1 37.0 49.3 27.9 47.3 43.5 50.1 58.6 36.1 18.9 49.7 28.2 33.3 119.2 45.8 29.9 31.5 19.8 38.5 32.2 35.5 19.6 27.0 29.2 40.3 21.0 29.5 33.7 71.2 27.4 46.7 62.6 27.0 61.6 45.1 7.9 5.3 2.7 6.7 9.1 12.7 10.4 11.2 9.1 9.3 6.1 11.6 9.7 0.1 7.7 6.8 12.1 7.8 6.3 6.5 6.5 6.7 9.6 6.6 6.8 6.7 6.7 6.7 6.7 6.6 6.7 25.3 3.2 9.5 6.5 37.8 50.9 90.3 54.8 69.4 6.2 29.9 20.2 35.3 17.2 36.3 14.7 10.4 45.3 21.9 5.0 21.5 28.6 10.1 23.8 28.3 32.0 4.8 20.4 11.1 22.5 48.1 35.6 13.7 23.2 13.3 13.3 17.5 13.4 33.1 0.0 10.5 12.1 32.6 16.4 22.8 4.4 28.9 18.5 28.4 2.8 19.7 7.4 13.4 8.0 12.9 19.8 7.5 20.3 29.3 104.3 4.0 32.5 24.0 4.7 6.6 51.8 49.8 16.5 20.4 58.7 37.8 35.7 31.1 28.6 18.3 76.6 DLAT "DLTA, E2, PDC-E2" ENSG00000150768 "Dihydrolipoamide S-acetyltransferase" P10515 11 112025408-112064404 "Citric acid cycle related proteins, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Carbohydrate metabolism, Glucose metabolism, Tricarboxylic acid cycle" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "tongue: 89.4" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 100.5;Distal tubular cells: 74.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003782, HPA040786, HPA062766" Supported Supported Mitochondria NA NA 44000 "Cluster 44: Non-specific - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 1: K-562 - Erythropoiesis" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "CAB003782: , HPA040786: AB_2677136, HPA062766: AB_2684864" "unprognostic (4.57e-3)" "unprognostic (1.75e-1)" "prognostic favorable (6.19e-6)" "unprognostic (7.68e-2)" "unprognostic (2.41e-1)" "unprognostic (1.70e-2)" "prognostic unfavorable (7.49e-5)" "unprognostic (8.68e-2)" "unprognostic (5.36e-2)" "unprognostic (2.93e-1)" "unprognostic (2.23e-3)" "unprognostic (6.25e-2)" "prognostic favorable (1.95e-14)" "unprognostic (5.82e-2)" "unprognostic (4.12e-2)" "unprognostic (2.17e-1)" "unprognostic (6.15e-2)" 24.7 16.5 7.7 13.3 8.3 7.9 14.5 9.5 9.3 11.0 10.4 24.7 18.3 10.0 13.4 19.5 13.0 8.5 69.4 8.1 11.1 33.8 15.5 11.7 16.1 8.3 8.9 9.5 6.8 31.7 8.5 13.1 9.7 14.5 26.0 10.8 16.8 14.8 75.4 10.3 16.5 13.4 8.2 9.9 14.3 9.9 9.4 12.7 20.2 89.4 18.2 14.2 8.1 8.0 18.7 16.4 28.2 34.4 41.6 30.5 26.5 26.6 18.2 34.8 38.7 52.8 56.7 85.4 46.0 28.7 42.6 41.0 65.7 34.2 38.9 27.3 30.2 51.9 17.9 39.2 29.0 64.9 26.6 36.9 37.7 32.0 35.2 24.2 33.9 41.7 88.4 42.6 41.2 16.6 25.4 66.9 30.3 58.6 35.4 45.4 38.0 93.3 64.4 21.4 51.2 27.8 30.7 93.4 20.5 30.9 67.4 42.9 17.8 29.1 29.1 29.1 33.0 11.1 19.4 127.5 7.7 73.0 22.7 9.1 3.8 3.0 4.3 5.8 5.4 5.6 4.9 5.1 5.8 4.0 5.6 5.1 0.3 4.7 6.1 4.5 5.8 5.0 7.7 8.3 9.5 9.3 8.1 11.1 8.3 8.9 9.7 8.2 9.4 8.0 7.6 12.8 14.5 15.3 13.8 11.2 9.2 18.2 14.2 8.1 9.2 5.8 100.5 15.7 13.2 11.0 0.0 21.2 6.4 26.3 74.3 18.7 3.9 15.8 11.6 9.6 17.3 18.1 18.0 11.4 39.6 11.7 11.7 12.1 3.8 13.5 7.5 15.5 18.7 8.4 24.4 17.8 24.4 8.8 7.5 3.2 6.2 9.5 17.8 9.4 16.7 10.4 4.1 11.1 19.7 14.1 9.2 10.9 19.4 7.0 19.0 37.6 30.3 11.1 0.0 14.2 19.9 25.1 18.3 21.1 9.8 17.4 8.5 26.3 26.7 9.3 DLST "DLTS, KGD2, OGDC-E2" ENSG00000119689 "Dihydrolipoamide S-succinyltransferase" P36957 14 74881891-74903743 "Citric acid cycle related proteins, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Tricarboxylic acid cycle" "Acyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003010 Supported Supported Nucleoplasm,Mitochondria,Cytosol NA NA 70000 "Cluster 15: NK-cells - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 21: OE19 - Mitochondria" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm "Mitochondria, Cytosol" "HPA003010: AB_1078679" "unprognostic (1.62e-1)" "unprognostic (3.01e-1)" "unprognostic (2.45e-3)" "unprognostic (6.36e-2)" "unprognostic (1.29e-1)" "unprognostic (1.21e-2)" "unprognostic (1.16e-1)" "unprognostic (5.83e-2)" "unprognostic (3.03e-1)" "unprognostic (1.37e-1)" "unprognostic (2.12e-2)" "unprognostic (1.18e-1)" "prognostic favorable (1.13e-12)" "unprognostic (3.29e-2)" "unprognostic (1.08e-1)" "unprognostic (1.66e-1)" "unprognostic (4.55e-3)" 64.5 85.5 33.5 32.3 34.7 75.0 59.6 35.8 34.7 62.1 43.8 63.3 58.7 47.5 43.2 62.9 46.1 36.2 129.0 30.8 35.1 100.4 78.4 48.5 36.9 35.8 34.5 45.8 44.8 78.8 35.4 44.8 34.3 41.3 59.3 37.1 46.5 43.5 144.7 64.3 58.3 52.1 33.6 46.1 57.7 29.3 37.3 42.5 42.9 224.2 45.7 58.0 49.7 32.5 79.1 81.1 63.7 45.4 98.1 110.6 97.5 106.3 107.8 106.8 99.0 80.9 88.1 81.0 44.3 118.1 48.1 87.8 109.0 105.6 112.0 61.5 43.3 68.4 66.3 74.8 101.4 49.5 45.4 114.0 90.5 103.8 126.7 95.5 106.1 36.6 53.4 55.6 110.3 112.0 59.0 69.7 55.0 146.6 79.0 73.8 93.8 46.7 125.8 100.8 75.5 64.1 100.6 129.4 71.3 54.2 121.7 70.5 90.8 63.8 83.2 79.5 74.0 38.7 43.7 73.4 93.9 47.9 68.8 3.0 1.3 2.3 2.1 2.0 1.8 1.6 1.9 1.6 2.1 1.0 1.5 2.2 1.3 3.5 1.8 2.8 2.0 1.5 33.5 34.7 35.8 34.7 30.8 35.1 35.8 34.5 34.3 33.6 37.3 32.5 24.2 6.4 4.8 14.0 22.7 26.4 23.5 19.7 21.6 19.1 25.1 20.4 28.5 21.5 10.1 20.2 31.3 41.0 27.7 41.9 56.7 37.8 7.3 10.9 20.4 19.8 14.8 22.5 21.9 25.7 38.8 25.6 30.5 18.9 21.0 19.4 23.2 43.6 32.1 13.5 24.6 31.8 12.2 20.9 19.0 6.2 18.0 18.8 23.2 13.1 27.1 10.0 20.6 18.6 18.5 44.3 28.0 20.7 20.0 28.2 49.8 73.3 8.7 20.8 26.3 18.3 24.0 12.1 15.3 34.2 28.4 79.5 23.1 19.3 40.5 27.7 DMPK "DM, DM1, DM1PK, DMK, MDPK, MT-PK" ENSG00000104936 "DM1 protein kinase" Q09013 19 45769709-45782552 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" Cataract "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 44.1;Sertoli cells: 59.2;Smooth muscle cells: 34.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "RH-30: 85.1" "Low region specificity" "Detected in all" "Region enhanced" "Detected in many" "spinal cord: 8.7" "HPA007164, HPA008905" Enhanced Approved Vesicles,Cytosol NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 38: Heart - Muscle contraction" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 48: Smooth muscle cells - ECM organization" Cytosol Vesicles "HPA007164: AB_1078687, HPA008905: AB_1078685" "unprognostic (7.44e-2)" "unprognostic (2.66e-1)" "unprognostic (1.76e-3)" "unprognostic (2.61e-3)" "unprognostic (1.29e-1)" "unprognostic (5.46e-2)" "unprognostic (8.67e-2)" "unprognostic (1.50e-1)" "unprognostic (1.31e-1)" "unprognostic (1.67e-1)" "prognostic favorable (9.39e-5)" "unprognostic (1.93e-1)" "unprognostic (1.60e-2)" "unprognostic (1.19e-1)" "unprognostic (1.18e-1)" "unprognostic (3.03e-2)" "unprognostic (4.24e-3)" 24.2 68.3 22.1 17.5 24.0 3.0 19.1 22.2 33.1 42.8 25.6 121.5 15.8 92.7 5.3 33.4 61.2 13.9 171.3 21.8 21.6 20.3 8.8 29.8 5.2 24.0 23.8 31.1 34.3 2.9 37.9 8.8 22.3 56.4 4.8 4.1 18.6 37.6 173.6 12.3 34.6 59.9 21.9 17.8 51.7 13.2 23.8 4.2 21.7 143.2 1.3 69.1 34.3 21.3 11.7 16.7 13.5 10.7 13.4 12.9 10.5 26.1 22.2 10.5 8.8 2.2 6.6 2.9 2.8 32.9 9.2 15.1 3.0 1.5 2.2 12.4 16.6 0.8 22.6 1.4 12.6 0.1 5.4 22.8 8.0 6.4 1.7 24.2 3.6 2.1 8.6 8.0 15.4 13.7 1.6 3.8 8.8 4.8 3.3 5.0 85.1 6.4 4.7 11.5 10.2 13.5 13.6 27.6 9.3 4.8 28.6 5.5 8.4 9.2 10.4 8.3 15.0 16.8 11.5 2.9 9.5 1.3 13.1 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 22.1 24.0 22.2 33.1 21.8 21.6 24.0 23.8 22.3 21.9 23.8 21.3 10.5 0.0 2.2 44.1 3.7 8.0 8.1 3.8 5.7 5.7 9.6 9.9 3.7 4.3 3.2 3.7 8.4 2.7 4.2 4.7 1.9 2.7 1.5 8.7 8.6 7.9 10.1 0.4 16.4 17.3 2.0 8.4 8.2 6.3 0.0 9.7 9.3 1.5 0.8 5.0 12.4 8.2 8.2 1.6 9.8 1.8 7.2 0.8 7.2 10.3 0.4 2.6 5.2 26.7 10.0 5.8 4.5 23.3 3.1 4.0 3.8 31.7 7.1 7.4 59.2 27.6 34.9 7.2 6.4 10.1 6.8 1.6 4.5 5.4 5.1 4.6 DNMT1 "CXXC9, DNMT, MCMT" ENSG00000130816 "DNA methyltransferase 1" P26358 19 10133342-10231286 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, Chromatin regulator, DNA-binding, Methyltransferase, Repressor, Transferase" "Deafness, Disease variant, FDA approved drug targets, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 388.1;Spermatocytes: 229.6;Syncytiotrophoblasts: 323.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002694, CAB005876" Enhanced Supported Nucleoplasm NA Yes "Cluster 6: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 47: Cytotrophoblasts - Unknown function" Nucleoplasm "CAB005876: AB_731983, HPA002694: AB_1847810" "unprognostic (3.51e-1)" "unprognostic (1.20e-2)" "unprognostic (1.26e-2)" "unprognostic (1.40e-1)" "unprognostic (3.62e-1)" "unprognostic (7.59e-3)" "prognostic unfavorable (1.46e-4)" "unprognostic (2.90e-1)" "unprognostic (4.23e-3)" "unprognostic (1.10e-2)" "unprognostic (1.07e-1)" "unprognostic (1.11e-2)" "unprognostic (1.28e-3)" "unprognostic (7.81e-3)" "unprognostic (1.73e-1)" "unprognostic (8.11e-2)" "unprognostic (1.46e-1)" 7.1 3.9 0.9 16.9 2.9 23.1 7.0 11.7 3.1 9.1 0.0 6.9 6.6 7.3 3.1 7.7 6.5 6.2 4.8 2.1 6.6 3.0 3.9 7.8 26.2 3.8 4.5 5.6 3.6 4.3 4.5 26.0 5.7 4.5 6.8 7.5 5.6 4.6 5.3 7.9 7.9 8.8 0.3 8.1 6.3 12.4 3.3 20.6 6.3 5.0 24.9 7.3 6.4 10.6 77.0 40.6 49.5 45.8 24.6 24.0 138.8 52.4 43.9 77.5 74.9 50.6 40.8 138.3 33.8 30.0 38.6 46.6 68.4 44.2 68.4 57.5 100.9 181.5 39.5 27.1 9.6 91.5 73.4 11.5 9.3 68.5 24.1 18.4 39.9 37.6 75.0 82.8 63.3 37.6 109.2 50.4 87.5 38.3 76.6 117.1 67.9 77.2 21.5 49.3 64.5 41.5 58.2 26.2 16.5 33.6 28.9 42.2 31.8 111.3 42.2 73.0 84.4 49.6 69.5 166.8 35.0 68.5 87.1 20.3 21.2 5.9 29.8 22.0 25.1 14.2 22.8 20.4 19.3 20.0 25.5 20.5 4.6 42.6 13.8 31.9 21.9 12.6 0.9 2.9 11.7 3.1 2.1 6.6 3.8 4.5 5.7 0.3 3.3 10.6 36.4 6.4 26.5 12.7 38.0 29.6 20.7 26.8 21.1 86.7 32.6 29.6 14.6 7.2 28.2 22.0 56.3 388.1 54.4 29.0 13.7 26.0 46.1 48.1 42.0 38.9 15.7 109.6 17.6 14.3 73.2 33.6 33.6 60.3 37.2 43.6 25.0 14.8 76.8 65.6 22.6 25.5 38.7 31.4 47.8 50.8 28.0 57.9 14.2 15.0 52.5 32.2 123.6 14.6 20.1 21.1 11.3 28.6 73.4 16.3 4.5 9.3 42.8 50.2 13.1 22.6 32.8 229.6 145.3 41.6 22.4 323.7 70.4 38.7 43.1 16.6 DNMT3A ENSG00000119772 "DNA methyltransferase 3 alpha" Q9Y6K1 2 25227855-25342590 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Chromatin regulator, DNA-binding, Methyltransferase, Repressor, Transferase" "Cancer-related genes, Disease variant, Dwarfism, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 127.2;Horizontal cells: 95.9;Rod photoreceptor cells: 143.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "NTERA-2: 59.6;REH: 59.5;SH-SY5Y: 71.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009469, HPA026588" Approved Supported Nucleoplasm NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 9: Photoreceptor cells - Phototransduction" Nucleoplasm "CAB009469: AB_2093990, HPA026588: AB_1847812" "unprognostic (2.38e-1)" "unprognostic (2.94e-1)" "unprognostic (5.65e-2)" "prognostic unfavorable (1.55e-4)" "unprognostic (8.38e-2)" "unprognostic (7.27e-2)" "prognostic unfavorable (1.58e-4)" "unprognostic (2.24e-1)" "unprognostic (7.25e-2)" "unprognostic (2.72e-1)" "prognostic favorable (1.18e-4)" "unprognostic (2.35e-2)" "prognostic unfavorable (2.49e-4)" "unprognostic (1.43e-1)" "unprognostic (1.87e-1)" "unprognostic (1.14e-1)" "unprognostic (2.70e-2)" 5.6 9.0 8.9 9.8 12.6 8.7 6.2 9.3 10.7 9.1 2.4 11.3 6.7 9.3 8.7 6.0 7.5 6.3 5.9 8.8 7.9 11.3 5.3 7.3 11.1 9.0 7.6 13.0 8.3 4.2 11.5 15.7 8.6 7.2 6.6 15.4 6.2 5.9 21.0 4.9 8.9 7.1 5.2 13.4 8.5 5.2 9.4 20.6 6.9 10.2 9.0 7.3 6.2 11.3 1.6 8.1 34.6 8.3 3.8 2.7 45.2 1.9 2.2 4.7 3.8 21.1 13.2 0.0 4.7 4.7 3.5 2.2 3.8 5.2 2.8 5.7 4.3 14.7 12.8 25.4 8.8 2.9 7.6 8.2 2.6 6.0 2.2 9.1 19.5 34.0 18.0 2.9 3.5 20.6 33.7 36.5 59.6 14.3 4.2 59.5 32.5 3.8 2.9 3.4 18.6 71.5 2.7 19.6 6.2 29.5 2.1 16.2 6.8 5.4 4.7 1.0 2.5 5.6 5.1 19.6 2.2 8.4 5.5 2.8 1.0 2.1 2.7 1.7 4.0 1.3 1.7 2.4 1.3 1.6 4.6 3.9 2.5 5.5 2.7 2.3 1.9 1.2 8.9 12.6 9.3 10.7 8.8 7.9 9.0 7.6 8.6 5.2 9.4 11.3 18.5 6.4 13.1 28.1 11.0 5.2 10.2 6.6 5.7 73.3 12.1 9.8 15.8 5.7 9.9 20.2 127.2 40.6 15.3 6.3 5.9 16.9 1.6 13.3 19.1 20.5 13.1 15.8 49.4 9.8 10.7 16.4 9.7 10.7 37.4 37.3 11.0 6.4 23.2 95.9 43.2 11.4 2.0 14.2 3.9 1.9 19.3 13.7 7.2 38.4 7.4 20.6 13.4 36.7 63.4 9.3 9.4 15.4 9.8 12.4 6.2 6.6 7.3 143.5 19.7 15.1 14.3 2.8 14.6 8.1 2.6 32.2 19.6 26.1 12.1 10.2 DNMT3B ENSG00000088305 "DNA methyltransferase 3 beta" Q9UBC3 20 32762385-32809356 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Activator, DNA-binding, Methyltransferase, Repressor, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 5.3;Extravillous trophoblasts: 5.2;Horizontal cells: 5.0;Inhibitory neurons: 6.8;Sertoli cells: 6.6" "Cancer enriched" "Detected in all" 25 "testis cancer: 111.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 245.7;CACO-2: 95.8;HEL: 100.7;K-562: 98.6;NTERA-2: 333.9;SuSa: 174.4" "Not detected" "Not detected" "Not detected" "Not detected" "HPA001595, HPA001803, CAB069896" Enhanced Supported Nucleoplasm NA Yes "Cluster 23: Testis - Cell cycle regulation" "Cluster 5: NTERA-2 - Transcription" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "CAB069896: AB_2094115, HPA001595: AB_1847814, HPA001803: " "unprognostic (7.65e-3)" "unprognostic (3.52e-3)" "unprognostic (1.17e-1)" "prognostic unfavorable (5.04e-4)" "unprognostic (3.42e-1)" "unprognostic (7.27e-2)" "unprognostic (4.39e-4)" "unprognostic (4.18e-3)" "unprognostic (8.60e-3)" "unprognostic (8.48e-2)" "unprognostic (6.79e-2)" "unprognostic (4.65e-2)" "prognostic unfavorable (1.87e-7)" "unprognostic (6.62e-2)" "unprognostic (1.00e-1)" "unprognostic (1.50e-1)" "unprognostic (6.55e-2)" 0.8 0.6 1.2 0.8 1.5 3.6 1.3 2.4 1.6 1.3 1.0 0.7 0.8 1.0 3.1 0.8 0.7 0.8 1.0 1.2 1.6 1.7 1.2 0.7 0.9 1.4 1.3 0.8 6.0 1.1 0.6 2.0 1.3 0.8 0.7 3.0 1.2 0.6 0.5 3.8 0.8 0.9 1.0 1.0 0.9 5.8 1.4 3.7 1.7 0.2 0.9 1.3 1.1 1.4 3.9 5.3 27.0 6.2 0.5 2.1 245.7 3.5 2.4 3.6 3.8 95.8 4.3 10.0 9.7 1.7 4.3 2.2 17.6 1.7 3.0 1.2 14.0 100.7 3.3 18.5 0.9 4.6 9.7 2.3 1.9 5.5 1.1 1.8 6.6 6.2 98.6 2.7 1.4 15.7 15.6 86.1 333.9 8.8 3.2 15.4 4.5 2.3 9.1 4.2 8.6 5.7 5.9 8.5 2.5 174.4 5.8 5.5 1.6 5.5 12.3 2.8 2.6 5.9 2.8 3.8 2.6 27.4 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 1.2 1.5 2.4 1.6 1.2 1.6 1.4 1.3 1.3 1.0 1.4 1.4 1.6 0.0 1.5 3.9 0.1 0.9 0.2 0.3 0.6 2.1 1.5 1.3 1.3 0.0 0.8 0.0 2.1 5.3 0.3 0.2 0.0 1.3 0.1 0.8 0.9 1.6 0.0 4.6 1.1 0.6 5.2 1.2 0.5 2.2 0.0 1.3 0.7 0.6 0.8 5.0 6.8 0.3 0.0 0.3 0.3 1.0 0.0 0.7 0.0 1.9 0.1 0.8 0.0 1.5 1.3 1.0 0.1 0.4 1.3 0.3 0.1 1.3 0.1 2.5 6.6 0.3 0.9 0.1 2.6 0.9 1.3 4.8 0.3 0.8 0.6 0.1 DNTT TDT ENSG00000107447 "DNA nucleotidylexotransferase" P04053 10 96304409-96338564 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Terminal addition" "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 12 "lymphoid tissue: 329.1" "Group enriched" "Detected in some" 5 "Early spermatids: 11.3;Late spermatids: 6.8" "Not detected" "Not detected" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "naive CD4 T-cell: 1.3" "Low lineage specificity" "Detected in single" "Group enriched" "Detected in some" 5 "MOLT-4: 416.0;REH: 1415.1" "Not detected" "Not detected" "Not detected" "Not detected" "HPA036532, HPA044194" Supported Nucleoplasm,Cytosol NA NA "Cluster 24: B-cells - Unknown function" "Cluster 63: T-cells - Adaptive immune response" "Cluster 14: REH - Unknown function" "Cluster 34: Spermatids - Unknown function" Nucleoplasm Cytosol "HPA036532: , HPA044194: AB_10960525" "unprognostic (4.24e-1)" "unprognostic (1.00e-1)" "unprognostic (2.60e-2)" "unprognostic (1.86e-2)" 0.0 0.0 0.0 0.2 0.1 27.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.7 0.0 329.1 0.4 0.0 2.3 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 195.3 0.0 0.0 0.0 0.0 416.0 0.0 0.1 0.0 0.0 1415.1 0.0 0.6 0.0 0.0 0.4 0.0 0.0 2.1 0.0 0.3 0.4 0.0 0.0 0.0 0.4 0.7 0.0 0.2 0.1 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.3 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 6.8 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 DOLK "DK1, KIAA1094, TMEM15" ENSG00000175283 "Dolichol kinase" Q9UPQ8 9 128945530-128947603 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Kinase, Transferase" "Congenital disorder of glycosylation, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Spermatocytes: 33.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA066767, HPA068706" Supported Nucleoplasm,Nucleoli,Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 29: Non-specific - Vesicular transport" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" "Nucleoplasm, Nucleoli" Cytosol "HPA066767: AB_2732751, HPA068706: AB_2732118" "unprognostic (6.35e-2)" "unprognostic (2.69e-1)" "unprognostic (2.63e-1)" "unprognostic (1.30e-3)" "unprognostic (3.55e-1)" "unprognostic (2.81e-3)" "unprognostic (8.90e-3)" "unprognostic (3.26e-1)" "unprognostic (1.02e-1)" "unprognostic (3.01e-1)" "unprognostic (8.83e-3)" "unprognostic (1.83e-2)" "prognostic favorable (5.53e-4)" "unprognostic (3.20e-2)" "unprognostic (1.06e-1)" "prognostic favorable (6.88e-5)" "unprognostic (6.13e-3)" 9.6 14.3 6.6 6.3 6.3 1.5 7.8 6.7 6.7 7.4 8.6 7.5 7.6 9.3 13.5 8.6 8.9 7.9 10.5 6.5 7.1 9.1 10.5 9.1 6.8 6.9 7.6 6.7 14.5 16.8 5.9 9.3 7.3 10.0 6.6 4.4 12.0 10.0 6.7 9.9 7.5 9.4 6.5 8.0 10.6 14.5 7.6 5.1 7.8 7.1 6.6 8.6 5.9 6.8 11.7 42.5 14.8 22.0 42.6 22.2 20.0 23.7 38.1 28.5 21.0 33.7 17.9 6.4 12.3 34.6 40.3 80.3 20.3 29.6 14.7 10.7 17.8 8.0 27.4 24.5 43.0 8.8 13.5 31.1 27.0 30.8 16.8 16.7 28.1 9.1 19.7 10.0 31.3 56.9 7.3 7.3 19.0 33.0 26.0 7.2 19.5 25.1 25.7 17.3 13.5 15.1 31.4 25.6 14.1 13.7 44.8 11.4 23.6 25.6 9.2 32.5 19.8 9.4 25.0 6.4 24.2 8.0 19.9 2.7 15.4 6.9 11.2 15.3 10.1 11.8 9.9 12.3 16.6 12.5 12.8 13.2 2.2 13.0 21.2 9.3 16.8 10.5 6.6 6.3 6.7 6.7 6.5 7.1 6.9 7.6 7.3 6.5 7.6 6.8 8.5 6.4 4.1 2.9 2.6 1.8 3.6 13.9 4.6 9.1 4.4 4.3 3.5 10.0 10.9 7.3 8.4 25.6 3.5 5.2 0.0 15.7 15.1 5.9 7.2 9.2 1.2 3.6 1.2 14.2 16.4 8.1 5.1 3.6 1.3 7.5 16.1 9.2 13.5 5.0 2.2 3.5 12.2 5.2 2.7 3.7 12.2 2.9 3.6 1.9 2.8 10.7 5.2 2.5 1.7 11.1 7.5 6.0 1.5 4.4 7.5 9.0 11.4 7.1 0.0 7.0 15.7 33.8 15.1 3.3 1.3 18.2 2.3 15.8 5.7 2.1 DOT1L "DOT1, KIAA1814, KMT4" ENSG00000104885 "DOT1 like histone lysine methyltransferase" Q8TEK3 19 2163933-2232578 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Chromatin regulator, DNA-binding, Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 4 "testis: 99.7" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 66.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA011875, HPA071217, HPA074977" Uncertain Enhanced Nucleoplasm NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 71: Testis - DNA repair" "Cluster 28: BEWO - Transcription regulation" "Cluster 44: Endometrium - Transcription" Nucleoplasm "HPA011875: AB_2668552, HPA071217: AB_2686364, HPA074977: " "unprognostic (1.41e-2)" "unprognostic (1.44e-1)" "unprognostic (2.26e-1)" "prognostic favorable (1.69e-4)" "unprognostic (1.08e-1)" "prognostic favorable (6.00e-4)" "unprognostic (2.53e-3)" "unprognostic (2.21e-1)" "unprognostic (1.57e-2)" "unprognostic (1.67e-2)" "unprognostic (5.25e-3)" "unprognostic (8.18e-3)" "unprognostic (2.56e-1)" "unprognostic (1.73e-3)" "unprognostic (1.43e-1)" "unprognostic (1.12e-1)" "unprognostic (1.67e-1)" 11.4 12.9 3.7 10.5 7.6 22.1 8.9 9.9 9.1 8.8 4.9 12.1 12.5 10.0 1.1 14.7 8.6 5.2 9.7 5.1 3.7 19.7 15.1 18.3 8.0 7.5 4.9 10.5 15.4 2.0 13.9 5.4 6.2 9.7 3.9 8.5 9.9 1.9 12.2 14.5 17.6 3.4 1.7 17.3 12.7 99.7 7.9 7.0 15.6 2.8 5.0 7.2 9.8 11.2 27.7 14.4 48.4 26.5 3.5 5.2 63.5 15.2 3.4 8.3 6.6 18.4 10.1 31.6 7.3 10.0 7.0 24.0 16.1 8.6 3.9 16.4 20.0 29.6 26.7 18.3 5.5 42.8 52.6 5.0 6.3 15.9 8.1 6.8 6.7 17.8 36.2 32.7 6.6 15.6 34.1 46.4 37.4 17.4 25.2 34.8 13.6 21.8 4.6 12.9 31.9 24.7 10.7 31.8 20.2 12.7 14.3 32.4 9.6 22.9 20.7 34.2 30.1 29.9 42.8 22.0 22.6 28.6 13.7 0.1 0.1 0.8 0.2 0.0 0.3 0.1 0.1 0.0 0.2 0.1 0.1 0.0 0.0 0.7 0.2 0.2 0.0 0.2 3.7 7.6 9.9 9.1 5.1 3.7 7.5 4.9 6.2 1.7 7.9 11.2 9.3 32.1 16.3 12.4 9.5 17.7 14.7 4.7 10.2 27.2 12.7 8.4 7.1 11.5 7.2 9.2 66.7 6.1 15.9 29.1 3.9 11.5 37.6 14.2 10.7 10.2 20.8 8.6 7.8 12.2 13.8 11.0 27.5 28.2 6.3 15.9 5.3 14.4 9.9 13.5 6.8 12.0 4.1 12.3 30.4 18.2 3.1 19.0 12.4 10.3 8.5 5.5 8.2 10.6 15.0 13.9 28.6 3.4 8.6 12.9 35.6 3.1 7.6 28.1 0.0 14.2 10.3 32.4 23.0 12.2 19.9 16.3 6.3 15.3 15.9 15.3 DPAGT1 "ALG7, CDG-Ij, D11S366, DGPT, DPAGT, DPAGT2, GPT" ENSG00000172269 "Dolichyl-phosphate N-acetylglucosaminephosphotransferase 1" Q9H3H5 11 119096503-119108331 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Congenital disorder of glycosylation, Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA053878 Approved NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 29: Non-specific - Vesicular transport" "Cluster 1: K-562 - Erythropoiesis" "Cluster 55: Plasma cells - Humoral immune response" "HPA053878: AB_2682288" "unprognostic (1.66e-2)" "unprognostic (3.14e-3)" "unprognostic (1.76e-1)" "unprognostic (7.83e-3)" "unprognostic (6.50e-2)" "unprognostic (8.53e-3)" "prognostic unfavorable (2.03e-5)" "unprognostic (2.52e-1)" "unprognostic (3.95e-1)" "unprognostic (9.05e-2)" "unprognostic (2.08e-2)" "unprognostic (7.12e-2)" "unprognostic (2.19e-3)" "unprognostic (1.87e-3)" "unprognostic (1.08e-2)" "unprognostic (2.52e-2)" "unprognostic (4.57e-2)" 11.3 14.1 13.0 13.7 13.3 9.1 14.8 13.9 22.4 16.1 17.6 17.7 16.8 10.2 21.8 12.4 17.3 14.5 8.6 13.5 14.1 12.8 21.2 11.4 11.5 14.2 14.4 9.0 27.1 18.6 4.4 15.8 14.2 14.3 20.0 7.4 27.8 16.3 5.6 9.0 14.9 17.7 13.4 9.8 14.4 4.8 14.6 8.2 15.5 8.5 14.3 16.8 6.2 14.9 22.0 39.2 22.2 55.7 60.0 37.0 24.6 33.7 38.3 25.7 32.2 43.4 88.3 41.5 62.8 45.4 57.7 77.1 42.0 60.7 31.1 29.4 23.8 83.5 14.1 51.6 50.7 53.9 47.4 40.3 48.7 62.4 85.3 29.9 53.3 25.2 51.7 84.1 50.9 67.7 19.5 39.9 22.5 148.3 49.4 26.2 26.6 61.3 60.3 44.7 23.0 30.1 30.7 99.3 17.1 32.3 116.8 19.4 29.1 57.3 24.5 30.3 23.7 19.6 32.2 13.9 14.3 68.3 48.9 28.4 35.7 4.4 25.2 35.5 28.4 24.5 20.1 24.8 43.3 25.6 16.6 15.8 3.0 20.7 32.7 37.5 19.6 20.2 13.0 13.3 13.9 22.4 13.5 14.1 14.2 14.4 14.2 13.4 14.6 14.9 11.5 6.4 8.1 7.2 10.7 13.3 15.2 34.4 13.1 6.1 18.4 12.1 5.0 14.3 22.8 14.7 14.6 34.2 9.6 10.3 3.9 32.9 0.9 15.6 12.3 16.0 10.2 8.6 7.3 13.3 44.4 11.0 14.3 11.2 12.7 12.7 15.7 23.1 28.8 3.3 5.7 19.8 32.6 13.0 11.4 1.9 14.0 14.1 8.8 5.6 20.9 6.2 13.4 7.5 5.4 13.9 11.1 8.2 33.2 14.5 19.3 11.3 37.2 4.6 0.0 6.0 10.7 6.8 10.3 14.1 12.5 23.5 10.0 15.9 20.7 12.9 DPH1 "DPH2L, DPH2L1, OVCA1" ENSG00000108963 "Diphthamide biosynthesis 1" Q9BZG8 17 2030137-2043898 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" Transferase "Disease variant, Dwarfism, Ectodermal dysplasia, Hypotrichosis, Mental retardation, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 19.4;Gastric mucus-secreting cells: 21.4;Plasma cells: 12.0;Squamous epithelial cells: 13.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA069750, HPA073864" Approved Approved "Nucleoplasm,Cell Junctions" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 72: Non-specific - Transcription" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 59: Non-specific - Transcription" Nucleoplasm "Cell Junctions" "HPA069750: AB_2686188, HPA073864: " "unprognostic (5.54e-2)" "unprognostic (1.99e-1)" "unprognostic (1.62e-1)" "unprognostic (1.86e-2)" "unprognostic (1.50e-2)" "unprognostic (1.46e-1)" "unprognostic (2.21e-1)" "unprognostic (1.10e-1)" "unprognostic (3.93e-2)" "unprognostic (2.30e-1)" "prognostic favorable (1.78e-5)" "unprognostic (2.74e-3)" "unprognostic (2.10e-2)" "unprognostic (1.03e-1)" "unprognostic (3.40e-1)" "unprognostic (7.30e-2)" "unprognostic (1.41e-1)" 24.5 32.3 13.1 6.0 12.8 5.3 22.2 16.8 17.7 29.1 10.7 26.8 8.0 28.8 5.6 19.8 31.0 9.1 19.2 13.7 11.9 28.0 36.3 16.6 7.5 10.3 10.9 26.6 32.0 14.2 59.3 8.5 10.3 36.2 6.2 12.4 23.7 11.0 42.3 29.3 20.8 8.9 10.1 24.3 27.0 20.3 11.7 6.7 28.6 13.7 6.0 24.2 22.3 11.5 15.4 24.9 6.3 16.0 22.2 14.2 18.7 19.3 26.8 29.7 18.7 24.1 11.6 29.0 23.6 52.5 11.2 11.6 20.7 21.1 15.9 9.0 52.4 6.3 10.5 13.1 19.4 8.3 10.2 20.3 20.3 22.7 19.0 20.5 13.9 16.8 23.4 11.2 11.9 18.2 14.7 4.8 6.5 17.3 25.9 16.6 5.7 22.0 13.3 8.0 13.1 15.2 17.4 17.9 17.2 6.9 25.9 6.8 10.1 19.4 10.1 26.2 16.7 10.3 8.3 6.8 20.3 10.8 8.5 0.8 4.5 0.8 8.0 6.1 8.9 8.8 6.5 7.4 7.7 7.2 9.6 6.9 0.3 6.7 4.5 5.5 10.2 5.2 13.1 12.8 16.8 17.7 13.7 11.9 10.3 10.9 10.3 10.1 11.7 11.5 0.9 3.2 9.2 1.3 9.3 0.4 0.9 0.5 19.4 2.1 0.8 0.8 1.5 0.0 2.7 0.0 2.1 1.4 0.9 0.6 0.0 0.5 1.2 1.5 1.2 1.7 0.0 9.0 4.0 0.6 0.9 4.5 21.4 0.8 2.5 1.0 0.7 0.0 0.6 1.7 3.7 0.8 0.0 0.0 0.8 1.5 0.6 3.9 0.0 1.0 0.4 0.9 2.1 1.5 1.4 0.0 0.2 0.4 12.0 0.5 0.5 0.5 3.0 2.8 0.0 1.3 3.2 1.2 0.5 13.0 0.3 1.4 5.4 1.3 0.4 0.6 DPH2 DPH2L2 ENSG00000132768 "Diphthamide biosynthesis 2" Q9BQC3 1 43970000-43973369 "Enzymes, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA045796 Uncertain Approved Nucleoplasm Yes No "Cluster 22: NK-cells - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 16: U-266 - Nucleosome" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm "HPA045796: AB_2679456" "unprognostic (2.41e-1)" "unprognostic (1.15e-1)" "unprognostic (4.20e-3)" "unprognostic (9.13e-3)" "unprognostic (3.83e-2)" "unprognostic (1.30e-1)" "prognostic unfavorable (1.17e-8)" "unprognostic (1.38e-1)" "unprognostic (1.81e-1)" "unprognostic (3.72e-1)" "unprognostic (2.49e-1)" "unprognostic (3.42e-3)" "unprognostic (2.60e-1)" "prognostic favorable (1.37e-4)" "unprognostic (1.38e-1)" "unprognostic (2.41e-2)" "unprognostic (6.37e-2)" 8.2 11.5 9.3 10.8 9.6 7.0 7.9 9.0 10.2 7.2 9.0 9.7 7.3 7.7 6.1 11.8 8.2 5.5 11.6 9.1 8.5 13.2 12.6 7.1 12.4 8.7 9.2 7.2 15.9 10.2 8.8 6.6 9.0 8.1 9.2 3.5 9.5 6.7 32.8 10.5 9.0 8.9 8.6 11.8 9.7 7.2 9.4 8.8 7.4 17.0 10.9 12.3 6.7 9.5 25.0 28.5 12.2 26.8 9.2 9.6 41.6 13.0 13.9 32.9 26.9 36.1 23.8 41.4 21.4 13.3 17.0 28.1 41.7 36.8 18.4 28.0 36.1 42.4 36.1 37.9 24.1 49.9 23.4 14.9 40.6 39.2 21.0 10.0 23.2 32.0 55.4 23.1 16.8 28.6 44.6 28.3 86.3 40.5 31.4 37.6 28.2 67.4 20.6 19.5 42.8 49.3 17.2 43.1 32.6 16.3 18.2 34.3 15.4 16.1 36.7 28.6 52.4 55.3 98.7 43.0 14.2 55.0 24.1 0.0 6.6 0.4 6.1 9.4 9.0 8.3 6.4 6.5 10.1 8.8 6.4 9.3 0.6 10.3 4.8 8.4 6.6 6.3 9.3 9.6 9.0 10.2 9.1 8.5 8.7 9.2 9.0 8.6 9.4 9.5 5.8 0.0 4.8 5.2 14.4 22.9 13.2 8.9 8.6 6.8 10.3 10.0 9.3 7.2 5.2 1.8 10.4 14.8 8.8 4.8 5.9 16.5 0.3 4.0 5.6 7.6 12.0 6.3 6.9 18.8 16.2 6.2 8.6 4.3 4.5 6.9 2.5 5.7 8.6 3.3 6.5 8.1 4.1 3.7 7.1 1.0 8.4 4.4 5.4 0.0 9.2 4.4 12.3 4.0 6.9 15.2 3.0 3.8 11.5 23.6 3.8 9.0 6.0 6.0 0.0 6.5 8.0 9.4 24.9 10.3 27.1 8.6 6.9 12.7 13.7 9.0 DPH5 CGI-30 ENSG00000117543 "Diphthamide biosynthesis 5" Q9H2P9 1 100989623-101026088 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA046439, HPA076234" Approved Approved "Nucleoli,Golgi apparatus" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 52: Non-specific - Ribosome" "Cluster 30: Epithelial cell lines - Translation" "Cluster 32: Non-specific - Translation" "Golgi apparatus" Nucleoli "HPA046439: AB_2679667, HPA076234: AB_2797274" "unprognostic (1.31e-1)" "unprognostic (3.37e-2)" "unprognostic (1.98e-2)" "unprognostic (7.82e-2)" "unprognostic (1.22e-2)" "unprognostic (2.23e-1)" "unprognostic (2.81e-2)" "unprognostic (3.57e-2)" "unprognostic (8.59e-2)" "unprognostic (8.12e-2)" "unprognostic (1.37e-2)" "unprognostic (2.56e-1)" "unprognostic (1.58e-2)" "unprognostic (2.15e-1)" "unprognostic (7.09e-2)" "unprognostic (1.88e-1)" "unprognostic (9.00e-2)" 12.5 23.2 17.2 8.4 17.8 10.7 28.8 17.3 22.5 23.2 18.3 14.6 7.1 17.2 23.8 13.7 26.2 11.6 23.5 17.4 18.7 19.5 25.3 10.1 18.1 17.8 18.0 49.8 31.4 20.0 15.5 12.3 17.8 15.0 17.5 8.8 11.9 17.1 20.8 15.0 11.2 19.7 17.6 15.4 14.1 9.8 19.0 29.0 20.7 25.0 25.4 14.7 13.3 18.0 28.1 30.1 40.1 37.0 48.3 154.7 34.9 24.9 42.9 41.0 34.5 35.3 7.7 46.0 33.2 22.2 23.1 20.0 47.5 41.1 62.6 20.0 35.8 22.1 26.7 71.4 84.1 33.4 13.8 97.1 63.9 38.8 118.6 67.4 64.8 33.4 62.6 16.7 70.3 26.3 40.7 36.7 31.5 15.2 46.4 37.8 51.1 32.6 50.0 25.7 44.2 22.2 13.7 36.2 114.0 29.6 27.3 18.3 25.1 23.0 28.7 28.8 34.4 20.0 24.1 31.9 31.5 29.6 7.9 5.7 7.5 4.6 16.1 8.9 21.7 19.2 17.9 17.7 13.6 15.1 24.0 20.9 2.7 24.7 10.6 9.8 12.8 10.2 17.2 17.8 17.3 22.5 17.4 18.7 17.8 18.0 17.8 17.6 19.0 18.0 8.1 6.4 14.6 17.0 30.3 15.8 17.0 24.2 19.9 5.3 18.7 12.3 23.8 21.5 12.7 7.3 0.0 26.2 10.1 4.7 23.5 14.0 1.8 14.2 19.6 11.2 10.2 17.7 12.0 18.4 27.8 13.5 5.6 8.2 25.4 29.0 12.1 29.3 18.9 1.7 14.6 15.0 22.4 28.4 13.1 3.0 27.1 14.0 12.4 8.4 27.7 16.5 27.8 27.2 28.3 8.9 12.9 13.9 10.3 10.8 8.1 30.9 16.8 6.5 6.6 16.6 12.5 15.7 17.6 17.0 18.0 13.0 19.4 33.4 23.7 11.3 DPM1 "CDGIE, MPDS" ENSG00000000419 "Dolichyl-phosphate mannosyltransferase subunit 1, catalytic" O60762 20 50934867-50958555 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Congenital disorder of glycosylation, Congenital muscular dystrophy, Disease variant, Dystroglycanopathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA051818 Approved NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 8: Non-specific - Mitochondria" "Cluster 39: CACO-2 - Unknown function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "HPA051818: AB_2681624" "unprognostic (2.21e-2)" "unprognostic (4.94e-2)" "unprognostic (1.16e-1)" "unprognostic (4.24e-3)" "unprognostic (1.65e-1)" "unprognostic (3.27e-2)" "prognostic unfavorable (1.94e-6)" "unprognostic (1.10e-1)" "unprognostic (7.49e-2)" "unprognostic (2.53e-2)" "unprognostic (1.29e-2)" "unprognostic (3.61e-2)" "unprognostic (3.02e-3)" "unprognostic (4.98e-2)" "unprognostic (2.59e-1)" "unprognostic (3.58e-1)" "unprognostic (2.74e-1)" 40.9 53.4 23.0 34.3 23.9 59.3 42.7 24.4 31.9 31.5 26.1 38.6 36.9 39.4 47.6 45.3 32.6 36.1 60.6 24.4 24.5 47.0 63.1 29.7 56.0 23.3 22.8 38.7 48.6 43.0 25.4 45.1 23.5 34.3 42.7 27.2 38.5 31.0 57.3 34.6 39.0 37.4 23.8 37.1 38.1 39.7 23.1 43.9 48.4 55.2 53.6 51.6 33.3 27.6 139.9 55.4 83.6 50.5 72.1 80.8 92.1 52.6 62.1 102.9 80.7 252.1 110.2 84.1 112.9 71.1 141.9 156.2 68.5 129.0 103.9 40.7 53.9 87.7 69.5 171.2 101.6 141.4 50.5 70.0 187.0 71.5 73.7 66.4 80.1 89.0 135.3 104.2 103.3 61.3 127.6 148.9 85.3 131.8 124.8 69.7 120.7 112.6 102.6 83.4 62.5 68.5 135.8 203.8 189.1 64.2 138.8 164.5 66.1 130.8 109.2 76.6 112.6 74.2 99.7 122.0 143.7 92.4 60.4 13.5 16.3 17.6 16.4 18.5 20.0 17.9 18.6 17.9 20.3 16.1 20.0 22.4 20.0 19.1 18.6 21.7 19.5 16.1 23.0 23.9 24.4 31.9 24.4 24.5 23.3 22.8 23.5 23.8 23.1 27.6 36.8 19.2 42.3 27.1 37.3 116.5 143.4 248.4 29.0 11.7 37.1 24.9 48.8 35.8 119.5 31.3 2.1 153.1 46.4 31.7 117.4 75.9 207.8 49.3 38.0 53.0 23.4 30.7 35.6 73.8 104.9 53.7 18.8 57.5 74.3 25.1 49.2 67.9 87.9 5.0 31.0 52.5 144.5 42.0 58.4 43.8 56.8 36.7 49.8 18.7 65.8 27.3 43.3 20.1 34.2 70.5 50.2 51.6 33.2 73.7 40.7 96.4 135.7 12.6 72.3 50.4 71.5 109.9 103.6 32.0 105.6 245.4 47.8 36.5 55.3 125.9 DSTYK "DustyPK, KIAA0472, RIP5, RIPK5, SPG23" ENSG00000133059 "Dual serine/threonine and tyrosine protein kinase" Q6XUX3 1 205142505-205211702 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Horizontal cells: 89.2;Melanocytes: 90.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044140 Approved NA NA "Cluster 34: Basophils - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 62: Horizontal cells - Visual perception" "HPA044140: AB_10965031" "unprognostic (1.42e-2)" "unprognostic (1.07e-2)" "unprognostic (7.92e-2)" "unprognostic (1.02e-3)" "unprognostic (1.39e-1)" "unprognostic (2.66e-1)" "unprognostic (1.43e-2)" "unprognostic (9.01e-2)" "unprognostic (1.81e-1)" "unprognostic (1.06e-1)" "unprognostic (2.25e-3)" "unprognostic (1.20e-1)" "unprognostic (3.26e-2)" "unprognostic (7.80e-2)" "unprognostic (1.93e-1)" "unprognostic (1.55e-1)" "prognostic unfavorable (8.73e-5)" 4.5 7.2 11.5 3.8 11.1 19.2 6.7 11.5 12.1 6.4 6.8 6.0 2.7 7.9 5.8 5.5 7.2 4.5 4.9 11.8 11.3 7.5 2.2 6.1 4.0 13.5 10.7 11.1 4.5 13.1 5.5 6.0 13.7 5.6 3.6 13.5 4.4 6.9 9.6 12.0 4.1 7.1 9.9 6.2 4.2 5.1 11.5 6.2 6.8 6.8 4.5 5.2 5.4 13.5 9.9 6.3 6.6 8.1 9.5 15.9 4.7 12.0 12.1 12.4 8.4 2.9 5.3 7.3 3.5 20.6 6.9 6.9 7.3 7.8 12.4 3.5 7.8 13.3 8.1 3.1 8.5 3.7 6.8 9.4 11.6 12.7 12.0 14.7 9.2 5.2 17.4 4.8 10.0 6.8 2.9 3.3 7.2 1.8 7.4 2.6 12.1 6.5 8.4 6.1 3.7 7.2 10.3 10.5 34.5 7.7 7.8 4.9 9.2 7.7 7.7 11.8 8.2 4.8 3.7 4.1 9.0 5.1 28.2 8.1 1.9 3.6 2.4 1.5 2.3 1.5 1.8 2.0 1.7 1.7 2.6 1.9 2.7 2.8 1.0 1.2 1.1 1.0 11.5 11.1 11.5 12.1 11.8 11.3 13.5 10.7 13.7 9.9 11.5 13.5 15.8 28.9 15.5 26.4 15.3 14.9 7.2 10.5 14.2 48.0 14.5 13.6 13.6 12.8 15.1 16.5 33.3 6.8 15.1 3.8 5.9 12.5 11.3 16.3 37.7 16.1 12.7 31.6 35.1 9.1 6.1 19.4 8.2 11.6 24.1 43.2 28.5 6.9 8.8 89.2 36.6 6.2 6.1 23.6 15.6 25.2 16.4 11.4 90.7 21.5 20.6 45.1 23.7 17.1 43.0 10.6 5.0 18.0 11.1 10.7 6.1 6.9 24.7 37.3 26.3 22.4 16.4 22.3 13.0 10.1 13.9 2.6 15.1 27.8 7.5 6.7 DTWD1 "MDS009, MGC111207" ENSG00000104047 "DTW domain containing 1" Q8N5C7 15 49621037-49656232 "Enzymes, Predicted intracellular proteins" "tRNA processing" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA042214 Uncertain Approved "Nucleoplasm,Nucleoli rim,Mitotic chromosome,Vesicles" Yes No "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 29: Non-specific - Vesicular transport" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 36: Stromal cells - Cell proliferation" "Nucleoli rim" "Nucleoplasm, Mitotic chromosome, Vesicles" "HPA042214: AB_2677903" "unprognostic (2.60e-2)" "unprognostic (1.73e-1)" "unprognostic (3.00e-1)" "unprognostic (3.70e-4)" "unprognostic (8.12e-2)" "unprognostic (2.37e-1)" "unprognostic (1.82e-1)" "unprognostic (9.87e-2)" "unprognostic (4.44e-3)" "unprognostic (4.25e-2)" "unprognostic (5.42e-2)" "unprognostic (1.48e-1)" "unprognostic (2.32e-3)" "unprognostic (1.02e-1)" "unprognostic (7.85e-2)" "unprognostic (2.80e-2)" "unprognostic (2.35e-1)" 19.6 11.8 7.7 13.0 10.1 5.4 18.2 8.2 9.1 27.4 6.5 21.1 7.4 22.6 16.8 13.3 21.1 23.0 11.0 9.0 8.9 11.0 11.5 10.9 12.9 5.7 6.9 22.7 33.3 11.5 9.2 12.8 6.0 15.7 11.9 8.8 21.5 14.7 10.3 12.2 9.1 20.5 6.4 9.0 14.9 9.5 9.9 11.7 17.6 21.1 10.0 20.4 15.9 9.8 10.0 11.9 21.2 11.5 41.3 84.1 16.6 29.3 28.6 36.8 27.5 4.2 8.3 16.7 20.3 38.7 16.8 17.8 15.6 15.8 37.7 10.8 11.2 13.8 23.5 14.5 29.1 18.0 11.1 38.8 20.4 24.3 29.7 32.9 15.5 19.3 26.3 17.3 41.7 23.3 12.3 15.1 12.4 22.6 15.7 17.4 44.7 64.9 12.3 7.1 18.6 14.4 34.7 11.5 27.3 22.1 12.1 25.4 10.7 43.6 17.3 25.6 32.3 13.2 22.2 10.0 37.5 53.9 28.3 8.7 9.7 5.2 6.8 11.7 9.8 9.7 10.3 11.6 12.8 10.1 12.0 11.5 2.6 13.9 15.3 25.3 8.9 6.0 7.7 10.1 8.2 9.1 9.0 8.9 5.7 6.9 6.0 6.4 9.9 9.8 39.9 19.2 15.0 36.6 16.6 19.2 15.4 31.9 18.2 41.8 23.0 34.0 18.8 12.8 22.1 35.0 31.3 23.4 27.1 4.7 31.3 20.1 21.0 27.8 88.1 23.6 15.5 20.8 57.2 21.0 27.7 49.9 20.4 14.1 7.0 29.3 25.4 14.9 19.5 18.5 55.2 19.2 40.7 16.4 14.9 11.2 37.9 16.7 16.0 18.7 10.4 20.3 18.6 33.7 66.1 20.8 10.3 28.2 27.0 21.5 9.5 22.0 37.9 40.0 6.6 35.5 46.7 51.2 44.3 19.6 19.0 9.7 16.2 35.4 17.1 12.7 DTWD2 FLJ33977 ENSG00000169570 "DTW domain containing 2" Q8NBA8 5 118836074-118988547 "Enzymes, Predicted intracellular proteins" "tRNA processing" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 70.4;Inhibitory neurons: 61.8;Oligodendrocyte precursor cells: 49.3;Oligodendrocytes: 43.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA053173, HPA054864" Approved Approved "Nuclear bodies" NA NA "Cluster 17: Basophils - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nuclear bodies" "HPA053173: AB_2682068, HPA054864: AB_2682629" "unprognostic (1.66e-1)" "unprognostic (1.60e-1)" "prognostic favorable (3.16e-4)" "unprognostic (4.80e-2)" "unprognostic (2.45e-2)" "unprognostic (1.42e-1)" "unprognostic (2.93e-1)" "unprognostic (1.15e-1)" "unprognostic (1.11e-1)" "unprognostic (2.77e-3)" "unprognostic (5.15e-2)" "unprognostic (2.90e-1)" "prognostic favorable (6.09e-5)" "unprognostic (1.25e-1)" "unprognostic (1.99e-1)" "unprognostic (5.93e-3)" "unprognostic (1.59e-1)" 3.1 3.3 1.3 2.3 1.3 1.2 3.6 2.3 1.8 5.1 2.2 3.3 3.2 2.6 2.3 4.2 2.3 3.2 6.5 1.2 0.8 6.5 4.5 2.4 2.3 1.1 1.4 1.7 3.0 4.7 0.8 1.8 1.2 3.4 3.3 3.4 3.2 2.7 10.5 3.3 2.7 3.2 1.0 3.0 2.7 2.4 1.3 2.0 9.1 6.3 2.3 2.9 1.3 1.4 4.3 2.6 3.6 5.3 2.0 1.0 3.6 3.9 2.7 5.5 6.3 1.8 3.2 3.6 6.9 3.4 2.6 4.8 6.0 4.4 6.9 1.2 4.2 4.9 4.3 2.9 1.7 5.9 6.1 1.5 7.4 2.4 2.4 3.2 1.8 6.4 3.8 5.5 3.7 4.2 4.9 3.6 3.8 3.1 1.4 2.0 3.3 1.9 7.0 6.2 1.8 3.3 3.9 4.2 5.4 2.9 9.7 3.9 2.2 6.9 5.1 2.3 5.7 3.8 6.6 2.8 4.0 3.5 3.4 0.9 0.3 0.1 0.2 0.3 0.3 0.4 0.3 0.3 0.3 0.6 0.4 0.4 0.6 0.5 0.3 0.5 0.1 0.4 1.3 1.3 2.3 1.8 1.2 0.8 1.1 1.4 1.2 1.0 1.3 1.4 2.7 9.6 3.6 33.6 5.7 2.8 2.7 3.9 8.6 12.0 5.4 2.8 11.7 8.6 4.7 7.3 16.7 2.7 3.7 4.0 9.8 2.9 12.8 4.2 1.9 2.0 4.2 12.6 70.4 8.3 1.1 3.0 9.7 3.6 0.0 4.5 1.8 5.6 3.9 20.2 61.8 2.0 4.1 2.6 2.5 20.3 2.5 4.5 7.2 21.5 4.6 7.3 4.1 49.3 43.9 1.9 5.2 2.2 8.0 2.1 3.7 12.1 3.1 9.1 0.0 4.5 2.8 12.7 17.4 10.0 3.7 0.7 2.8 7.3 3.4 3.4 DTX1 "hDx-1, RNF140" ENSG00000135144 "Deltex E3 ubiquitin ligase 1" Q86Y01 12 113056709-113098028 "Enzymes, Predicted intracellular proteins" "Notch signaling pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 11.1;lymphoid tissue: 11.8" "Group enriched" "Detected in many" 6 "Astrocytes: 48.3;Horizontal cells: 171.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 12 "Daudi: 109.1;REH: 45.1;U-698: 110.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA051249, HPA055275" Approved Supported "Nucleoplasm,Nuclear bodies,Cytosol" NA NA "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 62: Horizontal cells - Visual perception" "Nucleoplasm, Cytosol" "Nuclear bodies" "HPA051249: , HPA055275: AB_2682769" "unprognostic (2.13e-3)" "unprognostic (3.20e-3)" "unprognostic (4.24e-4)" "unprognostic (2.01e-1)" "unprognostic (7.48e-3)" "unprognostic (1.59e-3)" "unprognostic (2.49e-3)" "unprognostic (1.81e-1)" "unprognostic (9.55e-2)" "unprognostic (6.87e-2)" "unprognostic (2.19e-1)" "unprognostic (1.58e-1)" "prognostic unfavorable (3.02e-5)" "unprognostic (2.41e-2)" "unprognostic (4.70e-1)" "unprognostic (1.63e-1)" "unprognostic (4.78e-3)" 9.0 1.7 6.5 5.7 6.8 2.7 6.4 3.2 5.9 2.4 0.2 0.8 1.3 1.5 0.3 0.9 1.8 0.8 1.2 5.2 11.1 3.5 8.9 0.8 11.1 5.2 8.8 0.4 1.6 0.0 3.3 0.3 5.1 0.8 0.1 2.9 2.6 0.3 0.5 1.0 3.5 0.3 3.7 11.8 0.9 1.9 10.5 0.5 2.2 0.1 6.0 0.5 0.6 2.4 0.2 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 109.1 0.8 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.5 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.6 0.0 0.0 0.3 4.6 0.0 2.0 0.2 0.0 45.1 0.2 2.6 0.0 0.0 2.7 7.1 0.4 0.4 2.5 0.0 0.1 0.2 1.2 0.0 4.0 0.0 0.1 0.5 0.2 110.7 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 6.5 6.8 3.2 5.9 5.2 11.1 5.2 8.8 5.1 3.7 10.5 2.4 0.7 0.0 0.0 48.3 8.8 1.0 0.0 0.0 0.0 4.7 0.2 0.6 0.7 0.0 0.0 1.8 8.4 0.0 0.3 0.1 7.9 2.5 0.7 0.7 17.5 1.7 0.0 0.0 10.6 0.0 0.0 4.5 0.5 0.4 7.0 0.0 0.4 12.4 0.8 171.6 13.8 0.1 0.0 0.3 0.6 1.7 7.8 0.2 3.6 2.8 0.0 11.4 2.1 13.0 1.0 0.2 0.1 7.5 2.5 0.0 0.0 0.2 0.0 2.8 0.0 0.4 1.3 0.8 2.4 0.0 0.4 0.0 2.2 0.8 0.0 0.0 DTX2 "KIAA1528, RNF58" ENSG00000091073 "Deltex E3 ubiquitin ligase 2" Q86UW9 7 76461676-76505995 "Enzymes, Predicted intracellular proteins" "Notch signaling pathway, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "esophagus: 54.0" "Cell type enhanced" "Detected in all" "Basal respiratory cells: 87.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "A549: 67.7;CAPAN-2: 110.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA042931 Approved Supported "Nucleoplasm,Nuclear membrane" NA Yes "Cluster 8: Neutrophils - Inflammatory response" "Cluster 71: Testis - DNA repair" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Nucleoplasm, Nuclear membrane" "HPA042931: AB_2678227" "unprognostic (1.72e-1)" "unprognostic (1.73e-1)" "unprognostic (1.62e-2)" "unprognostic (1.58e-2)" "prognostic unfavorable (8.47e-4)" "unprognostic (2.85e-2)" "unprognostic (1.28e-3)" "unprognostic (7.54e-2)" "unprognostic (4.76e-2)" "unprognostic (2.28e-2)" "unprognostic (2.10e-2)" "unprognostic (6.56e-2)" "prognostic unfavorable (1.13e-8)" "unprognostic (2.87e-2)" "unprognostic (1.53e-1)" "unprognostic (1.50e-1)" "unprognostic (1.19e-2)" 10.0 5.0 5.6 12.3 6.3 5.1 10.3 3.3 10.1 17.4 13.8 15.8 10.2 9.3 1.1 54.0 10.5 9.3 6.8 4.3 5.9 5.4 8.7 10.3 10.9 11.1 8.1 8.1 10.5 8.4 6.7 5.3 8.1 13.7 8.1 4.4 30.4 3.9 12.5 31.0 13.3 4.3 3.8 13.3 14.2 28.1 13.5 9.0 7.9 2.7 10.1 12.1 27.2 12.8 31.8 67.7 9.9 14.7 5.5 5.4 21.2 6.8 5.7 7.2 9.9 19.1 110.9 9.8 4.7 6.8 38.1 23.2 5.3 32.1 4.5 22.1 11.3 5.6 14.4 16.9 7.4 8.2 13.7 9.6 19.1 18.7 10.0 5.6 5.5 17.2 17.3 14.3 8.8 15.3 12.6 28.6 14.4 23.8 10.2 13.8 9.1 17.7 3.4 24.4 3.9 8.2 10.9 18.4 9.3 8.6 18.5 21.6 5.8 40.5 19.0 13.8 27.1 10.7 13.7 11.2 8.8 8.8 21.3 17.7 11.6 17.2 8.6 13.3 6.2 6.6 7.1 8.5 10.1 7.3 7.1 7.9 22.8 4.2 18.8 17.8 11.0 8.4 5.6 6.3 3.3 10.1 4.3 5.9 11.1 8.1 8.1 3.8 13.5 12.8 7.3 6.4 5.0 5.2 13.1 33.9 19.5 87.2 23.3 2.6 7.1 4.8 2.3 4.3 59.2 7.3 8.4 18.5 12.0 39.1 3.9 19.4 33.0 8.1 3.1 5.9 9.1 3.8 5.7 10.8 13.5 6.5 61.2 10.7 3.8 3.2 7.1 4.3 21.6 3.3 5.2 25.6 22.4 11.0 7.7 10.4 5.6 14.5 7.2 19.7 10.0 5.7 8.2 18.1 10.0 23.1 37.9 4.9 13.9 20.0 21.0 3.2 62.8 9.2 6.6 3.0 7.3 11.0 11.0 27.0 35.4 37.6 9.7 1.9 26.1 62.5 DTX3 "FLJ34766, RNF154" ENSG00000178498 "Deltex E3 ubiquitin ligase 3" Q8N9I9 12 57604622-57609804 "Enzymes, Predicted intracellular proteins" "Notch signaling pathway, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Horizontal cells: 70.7" "Cancer enriched" "Detected in all" 4 "glioma: 54.0" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Group enriched" "Detected in many" 5 "NK-cells: 1.0;T-cells: 2.5" "Cell line enhanced" "Detected in many" "hTERT-RPE1: 84.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA059654 Approved Approved "Nucleoplasm,Nucleoli,Golgi apparatus" No No "Cluster 20: T-cells - T-cell receptor" "Cluster 35: Non-specific - Unknown function" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 48: Smooth muscle cells - ECM organization" "Nucleoplasm, Nucleoli" "Golgi apparatus" "HPA059654: AB_2684097" "unprognostic (2.31e-2)" "unprognostic (8.80e-2)" "unprognostic (2.06e-2)" "unprognostic (3.68e-1)" "unprognostic (3.35e-1)" "unprognostic (2.58e-2)" "unprognostic (6.91e-2)" "prognostic favorable (9.87e-4)" "unprognostic (1.84e-1)" "unprognostic (4.26e-2)" "prognostic favorable (1.44e-4)" "unprognostic (8.62e-2)" "unprognostic (5.44e-3)" "unprognostic (7.99e-2)" "unprognostic (8.81e-2)" "unprognostic (9.51e-2)" "unprognostic (3.48e-2)" 36.6 58.2 117.1 15.8 120.2 7.2 36.4 117.5 138.2 97.6 115.0 117.4 11.5 95.5 50.7 24.2 92.0 24.5 67.6 124.5 111.4 63.8 12.3 37.2 21.2 107.8 112.1 124.3 41.9 39.4 145.1 28.1 108.6 82.1 16.8 80.8 31.4 48.2 21.0 21.1 46.2 48.5 105.3 46.0 51.0 29.0 112.6 23.6 75.9 16.6 15.5 65.0 60.7 119.0 8.8 22.7 65.9 0.1 0.0 0.1 0.4 13.8 35.4 29.7 30.0 11.8 36.5 12.3 20.5 30.0 0.3 14.2 0.0 1.7 20.9 31.1 4.1 7.1 39.4 12.5 49.4 0.0 0.1 24.5 16.7 22.8 0.3 84.4 33.6 0.1 0.0 40.9 23.1 19.2 38.4 0.3 52.1 7.2 2.0 0.0 55.1 0.7 2.8 22.7 47.7 75.5 10.9 3.1 7.0 15.8 38.4 18.9 0.1 38.6 15.3 17.9 20.2 66.2 53.6 0.2 24.8 0.1 20.6 0.0 0.0 0.0 2.5 0.0 0.6 0.1 0.9 1.2 0.1 0.1 0.8 1.6 0.0 1.0 0.0 0.3 2.2 1.2 117.1 120.2 117.5 138.2 124.5 111.4 107.8 112.1 108.6 105.3 112.6 119.0 4.9 16.0 15.6 25.8 2.9 6.2 10.0 8.7 21.1 47.8 12.2 19.9 11.0 11.5 10.5 12.9 50.1 0.5 10.6 0.5 13.7 8.2 0.9 17.8 17.4 8.5 15.6 4.4 29.9 1.9 0.3 15.1 6.1 5.5 5.7 17.2 15.0 0.6 0.6 70.7 29.3 0.9 10.2 2.0 2.1 2.8 34.2 1.6 3.6 8.4 0.8 27.4 36.0 25.1 19.0 2.6 0.0 31.6 5.8 7.1 0.0 4.6 30.9 42.0 46.0 11.5 37.5 4.6 5.7 2.8 2.8 1.2 10.4 16.8 0.7 3.5 DTX3L "BBAP, RNF143" ENSG00000163840 "Deltex E3 ubiquitin ligase 3L" Q8TDB6 3 122564338-122575203 "Enzymes, Predicted intracellular proteins" "Antiviral defense, DNA damage, DNA repair, Host-virus interaction, Immunity, Innate immunity, Protein transport, Transport, Ubl conjugation pathway" "Chromatin regulator, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "BJ hTERT+ SV40 Large T+: 91.6;BJ hTERT+ SV40 Large T+ RasG12V: 112.3;GAMG: 87.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA010570 Uncertain Supported Nucleoplasm,Cytosol NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 64: Macrophages - Immune response" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Nucleoplasm, Cytosol" "HPA010570: AB_1847877" "unprognostic (8.15e-2)" "unprognostic (7.36e-3)" "unprognostic (5.04e-2)" "unprognostic (3.74e-3)" "unprognostic (9.51e-2)" "unprognostic (9.22e-2)" "unprognostic (1.82e-1)" "unprognostic (1.11e-2)" "unprognostic (9.23e-2)" "unprognostic (1.43e-1)" "prognostic unfavorable (8.99e-4)" "unprognostic (2.76e-2)" "unprognostic (2.33e-2)" "unprognostic (7.77e-2)" "unprognostic (9.28e-2)" "unprognostic (3.33e-2)" "unprognostic (2.61e-2)" 11.1 9.2 5.5 24.4 6.0 12.8 10.8 5.0 6.4 10.1 4.8 15.5 20.6 12.3 6.5 11.4 11.4 15.3 7.3 4.6 6.1 9.9 32.1 20.8 21.8 11.1 6.6 9.4 17.8 11.1 5.3 16.3 7.4 12.3 16.2 2.6 20.3 8.6 7.8 8.1 18.7 14.8 8.3 26.6 15.9 3.6 8.3 17.4 11.9 9.2 20.9 18.2 8.2 7.2 31.2 9.4 2.6 7.9 12.0 27.6 10.2 7.9 29.3 91.6 112.3 9.2 31.2 3.6 15.1 13.2 87.8 30.5 9.2 12.8 20.1 26.3 3.4 27.1 7.2 9.8 23.7 14.0 20.2 23.8 14.8 13.7 7.8 17.4 17.6 16.9 3.5 18.8 6.9 9.6 34.3 9.9 1.7 9.7 17.2 37.5 21.0 6.0 23.4 19.8 3.8 4.1 16.6 7.4 59.5 1.8 8.5 17.5 21.6 10.4 14.5 1.0 10.2 6.8 4.0 16.4 17.9 17.9 10.9 21.4 11.3 12.0 11.6 18.1 12.5 7.5 9.5 12.4 8.7 7.9 8.4 9.3 28.2 10.5 19.4 0.9 9.9 9.9 5.5 6.0 5.0 6.4 4.6 6.1 11.1 6.6 7.4 8.3 8.3 7.2 31.3 32.1 28.1 3.9 19.7 8.9 10.2 10.4 9.1 0.3 12.9 8.1 5.1 15.7 15.0 7.3 0.0 4.1 15.3 46.3 0.0 23.1 2.5 17.2 26.7 24.1 18.5 16.2 0.0 32.5 15.2 13.3 30.5 27.5 15.8 17.5 25.4 56.7 28.4 0.0 0.3 26.6 10.2 38.6 5.8 1.1 8.4 26.1 5.4 13.1 38.2 5.1 40.2 0.5 1.1 32.4 15.0 9.1 11.8 20.1 24.2 15.1 17.0 0.4 32.9 10.0 10.7 1.8 0.5 12.4 6.0 1.8 19.2 8.3 20.6 20.1 DTX4 "KIAA0937, RNF155" ENSG00000110042 "Deltex E3 ubiquitin ligase 4" Q9Y2E6 11 59171430-59208588 "Enzymes, Predicted intracellular proteins" "Notch signaling pathway, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 50.5" "Cell type enhanced" "Detected in many" "Distal enterocytes: 33.6;Oligodendrocytes: 33.9" "Cancer enhanced" "Detected in all" "thyroid cancer: 63.6" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "plasmacytoid DC: 2.8" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "BEWO: 62.8;CACO-2: 34.5;CAPAN-2: 37.7;OE19: 35.4;RT4: 95.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA056760, HPA059294" Approved Approved Vesicles NA NA "Cluster 29: Plasmacytoid DCs - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 15: RT4 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" Vesicles "HPA056760: AB_2683228, HPA059294: AB_2683969" "unprognostic (3.23e-2)" "unprognostic (1.57e-1)" "unprognostic (1.10e-2)" "unprognostic (4.98e-2)" "unprognostic (4.97e-2)" "unprognostic (5.03e-1)" "unprognostic (2.92e-1)" "unprognostic (1.06e-1)" "unprognostic (3.75e-1)" "unprognostic (1.14e-1)" "unprognostic (5.69e-2)" "unprognostic (3.04e-1)" "prognostic unfavorable (8.94e-4)" "unprognostic (5.51e-2)" "unprognostic (2.51e-1)" "prognostic favorable (5.81e-4)" "unprognostic (2.57e-3)" 10.4 1.9 13.9 5.5 21.2 9.3 9.5 21.4 20.0 8.0 8.2 17.5 16.4 3.8 1.9 4.7 5.8 4.9 3.2 13.2 21.2 8.5 32.5 18.1 5.3 30.2 22.4 15.0 7.9 1.0 4.1 14.8 27.0 7.5 17.2 10.4 21.7 3.1 1.4 3.9 14.4 2.5 33.5 6.7 11.6 1.7 25.6 1.5 10.2 1.7 6.5 15.0 3.9 50.5 4.8 5.7 30.5 0.6 8.5 0.5 62.8 0.4 2.7 0.3 0.4 34.5 37.7 11.6 2.1 0.7 1.2 16.5 9.5 11.8 0.1 0.8 0.5 0.1 6.6 11.2 2.4 0.9 2.3 1.4 19.3 0.1 0.5 2.1 0.0 2.1 0.1 1.1 1.4 2.7 0.5 0.1 16.1 35.4 1.5 4.1 27.1 1.3 2.6 95.2 0.0 0.1 24.3 6.4 0.8 7.7 4.9 0.5 0.3 0.1 4.9 0.1 0.0 0.4 0.1 1.1 0.2 2.8 2.6 0.7 0.4 0.4 0.0 0.4 0.0 1.0 0.0 0.0 0.6 1.3 0.0 0.0 1.5 0.0 0.2 2.8 0.0 0.1 13.9 21.2 21.4 20.0 13.2 21.2 30.2 22.4 27.0 33.5 25.6 50.5 8.9 19.2 16.8 9.4 3.1 1.7 3.2 7.9 2.2 2.0 2.9 3.9 1.4 28.6 21.8 7.3 0.0 15.0 6.9 33.6 0.0 10.2 0.4 1.5 8.1 3.6 4.9 0.0 12.0 4.9 19.2 7.2 12.2 3.0 1.3 4.9 5.7 23.1 3.7 0.0 8.4 10.5 2.0 2.5 2.5 0.4 4.1 2.7 5.4 3.7 0.9 30.3 0.0 7.5 33.9 10.8 16.3 3.4 0.0 3.1 19.8 9.1 14.9 2.0 0.0 22.1 3.6 0.4 1.7 1.8 1.3 5.5 1.2 5.9 18.5 22.5 DTYMK "CDC8, TMPK, TYMK" ENSG00000168393 "Deoxythymidylate kinase" P23919 2 241675747-241686944 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Nucleotide biosynthesis" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Erythroid cells: 108.6;Extravillous trophoblasts: 149.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA042593, HPA042719" Approved Approved Mitochondria NA NA 7000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Mitochondria "HPA042593: AB_10959590, HPA042719: AB_10960633" "unprognostic (1.90e-1)" "unprognostic (6.95e-2)" "unprognostic (4.14e-1)" "unprognostic (8.61e-2)" "unprognostic (1.89e-1)" "unprognostic (9.45e-2)" "prognostic unfavorable (1.73e-5)" "unprognostic (1.44e-2)" "unprognostic (2.64e-2)" "unprognostic (5.50e-2)" "unprognostic (2.60e-2)" "unprognostic (6.94e-2)" "prognostic unfavorable (1.22e-4)" "unprognostic (7.13e-2)" "unprognostic (6.81e-2)" "unprognostic (5.07e-2)" "unprognostic (9.19e-2)" 12.2 16.0 15.6 15.6 17.1 37.0 11.8 16.2 19.8 11.2 16.5 15.1 13.2 10.8 6.1 19.1 10.2 8.6 10.6 14.5 15.0 14.9 18.8 9.7 24.8 16.8 16.0 8.2 9.5 7.5 5.0 11.1 16.1 11.1 12.2 4.3 9.8 7.4 8.1 18.8 14.0 13.4 15.3 17.2 13.3 8.2 16.8 24.1 8.7 6.4 19.2 10.6 11.2 17.2 102.6 112.3 93.6 120.1 30.2 33.3 103.2 82.1 63.2 110.8 125.6 54.8 120.1 48.3 24.6 66.8 126.8 84.4 87.8 102.2 56.7 118.8 104.6 103.9 88.3 105.1 26.3 69.1 83.1 23.7 27.3 102.7 42.4 32.1 104.8 74.4 123.6 38.4 114.1 112.6 132.2 125.0 100.7 113.1 94.2 111.4 139.8 71.8 62.3 59.5 115.0 74.0 53.4 81.5 67.9 27.0 74.2 120.0 66.5 147.5 110.4 99.0 152.5 47.3 49.1 144.6 122.4 112.2 184.9 20.5 26.2 17.4 30.4 46.7 29.6 35.6 28.5 32.6 19.7 36.7 28.1 25.0 4.2 32.6 37.1 38.5 42.1 28.5 15.6 17.1 16.2 19.8 14.5 15.0 16.8 16.0 16.1 15.3 16.8 17.2 28.9 9.6 5.8 8.1 21.4 15.2 17.7 47.7 16.5 19.1 36.3 44.8 11.0 24.3 22.2 25.8 2.1 79.5 24.0 22.9 21.5 39.6 2.1 17.6 25.0 29.2 14.4 108.6 3.3 34.1 149.1 26.9 25.5 22.3 15.2 52.3 23.9 22.3 84.9 5.0 4.7 35.7 36.7 17.0 13.9 2.1 16.4 21.7 23.2 5.6 39.3 23.0 38.1 6.0 9.2 33.7 10.6 19.2 37.6 21.7 12.7 37.7 12.9 17.4 26.3 21.4 31.2 27.5 63.4 32.6 11.9 27.5 17.4 28.2 52.2 19.5 DYRK1A "DYRK, DYRK1, MNBH" ENSG00000157540 "Dual specificity tyrosine phosphorylation regulated kinase 1A" Q13627 21 37365573-37526358 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Host-virus interaction" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 156.7;Inhibitory neurons: 158.4;Microglial cells: 176.1;Oligodendrocyte precursor cells: 158.3;Oligodendrocytes: 157.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015323, HPA015810" Approved Approved "Nucleoli fibrillar center,Cytosol" NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 36: HEL - Hemostasis" "Cluster 44: Endometrium - Transcription" Cytosol "Nucleoli fibrillar center" "HPA015323: AB_1847922, HPA015810: AB_1847921" "unprognostic (2.71e-1)" "unprognostic (3.35e-2)" "unprognostic (1.27e-1)" "unprognostic (5.62e-2)" "unprognostic (4.17e-2)" "unprognostic (1.41e-1)" "unprognostic (1.67e-1)" "unprognostic (9.28e-2)" "unprognostic (1.02e-1)" "unprognostic (1.51e-1)" "unprognostic (9.95e-2)" "unprognostic (7.39e-2)" "unprognostic (9.09e-2)" "unprognostic (1.07e-1)" "unprognostic (2.92e-2)" "unprognostic (3.14e-1)" "unprognostic (1.40e-2)" 23.1 20.4 17.8 22.5 19.9 71.4 22.3 29.9 20.7 23.9 22.2 22.2 18.7 26.6 22.0 18.8 22.6 19.9 28.9 21.3 19.2 19.9 19.8 22.3 30.1 12.1 14.7 29.6 21.5 27.8 20.2 23.0 13.3 18.8 21.6 27.8 21.3 19.2 49.4 24.2 21.7 24.1 12.8 30.4 22.8 29.9 18.6 45.8 25.7 45.2 26.7 24.3 21.1 20.9 23.5 18.2 36.3 25.6 17.1 18.8 32.7 20.8 26.0 20.3 22.0 25.7 19.7 31.7 13.8 37.0 27.1 15.8 27.3 21.2 24.4 49.7 11.6 93.6 30.9 16.1 26.5 36.9 32.3 18.7 24.3 26.5 41.2 23.5 22.3 44.2 36.4 70.4 22.2 23.6 49.3 25.9 38.5 24.1 10.8 62.8 19.7 29.6 22.3 30.4 36.5 20.4 47.1 31.6 33.2 12.2 29.9 34.8 27.8 27.6 8.3 17.2 17.4 47.7 41.6 44.9 22.0 41.8 30.7 3.1 0.5 0.8 1.2 0.8 0.7 1.1 1.3 1.0 0.7 1.0 1.4 1.3 2.3 0.5 1.1 1.3 1.3 0.3 17.8 19.9 29.9 20.7 21.3 19.2 12.1 14.7 13.3 12.8 18.6 20.9 36.8 19.2 25.5 114.3 28.8 37.5 24.1 15.7 18.2 32.7 28.3 18.0 73.0 20.0 23.0 11.0 27.1 10.3 43.0 30.1 0.0 13.5 29.7 44.2 39.3 31.9 21.4 26.1 156.7 14.6 12.4 25.2 21.4 71.4 24.7 35.9 27.1 18.1 15.8 47.1 158.4 18.8 14.2 25.0 27.7 22.2 16.1 32.4 24.9 176.1 18.8 16.4 21.6 158.3 157.2 21.2 22.4 19.5 33.8 29.8 17.1 9.9 27.9 21.8 13.1 38.4 32.5 15.3 24.7 24.6 31.7 15.3 36.8 21.3 19.3 37.2 DYRK1B MIRK ENSG00000105204 "Dual specificity tyrosine phosphorylation regulated kinase 1B" Q9Y463 19 39825350-39834201 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Diabetes mellitus, Obesity" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 131.3;testis: 83.8" "Group enriched" "Detected in many" 12 "Early spermatids: 179.4;Late spermatids: 580.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "SH-SY5Y: 14.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028522, HPA028786" Uncertain Supported "Nucleoplasm,Mitotic chromosome" Yes No "Cluster 15: NK-cells - Transcription" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "Mitotic chromosome" "HPA028522: AB_2672656, HPA028786: AB_10670831" "unprognostic (2.22e-2)" "unprognostic (9.86e-2)" "unprognostic (4.55e-2)" "unprognostic (3.45e-3)" "unprognostic (1.96e-1)" "unprognostic (1.13e-2)" "unprognostic (2.25e-1)" "unprognostic (2.39e-1)" "unprognostic (6.02e-2)" "unprognostic (3.67e-2)" "unprognostic (8.93e-2)" "unprognostic (4.22e-2)" "prognostic favorable (8.83e-4)" "unprognostic (9.73e-2)" "unprognostic (1.12e-1)" "unprognostic (2.53e-2)" "unprognostic (3.88e-2)" 9.5 19.6 4.8 2.7 4.8 4.7 10.9 4.1 6.2 12.5 4.8 12.4 5.3 11.9 7.8 11.7 13.8 3.3 20.0 4.7 3.6 16.2 7.5 8.8 4.6 3.5 3.4 11.6 10.3 6.5 31.5 2.7 3.6 13.0 2.1 4.1 14.3 3.3 131.3 14.8 10.2 2.6 1.2 14.0 12.1 83.8 3.6 5.2 16.5 49.9 2.5 11.4 10.5 3.0 0.4 9.3 8.8 6.2 4.9 4.6 0.7 2.9 1.8 2.6 2.3 0.9 3.6 1.4 11.0 3.4 0.1 3.2 1.3 2.0 2.3 5.4 7.8 0.6 5.9 0.9 4.1 0.3 1.9 6.2 1.2 0.8 2.9 8.6 0.6 3.5 1.5 2.0 0.4 4.7 2.1 0.8 2.2 2.7 2.1 1.0 0.2 0.6 5.7 2.2 12.7 14.5 4.5 4.4 0.2 4.6 4.4 0.5 4.5 1.1 2.0 1.0 0.9 3.2 1.1 1.0 7.4 0.9 0.4 0.7 1.6 1.8 3.0 1.7 3.6 2.4 2.0 3.1 1.9 1.6 1.0 1.7 2.5 3.3 1.6 4.5 2.2 1.7 4.8 4.8 4.1 6.2 4.7 3.6 3.5 3.4 3.6 1.2 3.6 3.0 6.0 0.0 0.6 6.2 10.9 3.4 3.8 8.4 10.2 15.2 9.0 6.1 6.1 7.2 3.4 16.5 20.9 2.1 21.7 10.3 9.8 13.1 179.4 15.4 6.7 7.3 20.4 19.8 4.6 4.3 1.7 5.1 7.7 10.1 1.3 11.9 12.1 3.9 5.9 10.1 6.3 9.8 10.2 8.2 3.0 580.2 7.2 4.7 5.4 7.5 5.7 8.3 10.3 5.0 3.2 9.7 9.7 5.3 5.0 4.8 11.5 17.4 10.7 13.0 0.0 11.1 4.8 30.1 13.4 6.1 2.8 1.4 10.8 20.2 7.4 3.6 DYRK2 ENSG00000127334 "Dual specificity tyrosine phosphorylation regulated kinase 2" Q92630 12 67648338-67665406 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Ubl conjugation pathway" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 133.1;Horizontal cells: 80.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027230, HPA056902" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 15: NK-cells - Transcription" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm Cytosol "HPA027230: AB_1847925, HPA056902: AB_2683271" "unprognostic (5.86e-3)" "unprognostic (4.18e-1)" "unprognostic (4.08e-3)" "unprognostic (2.56e-3)" "unprognostic (1.18e-2)" "unprognostic (1.69e-1)" "unprognostic (3.37e-3)" "unprognostic (7.83e-2)" "unprognostic (2.83e-2)" "unprognostic (1.22e-1)" "unprognostic (1.04e-1)" "unprognostic (3.47e-1)" "unprognostic (2.12e-2)" "unprognostic (2.03e-2)" "unprognostic (1.38e-1)" "unprognostic (1.57e-1)" "unprognostic (1.35e-1)" 9.9 4.6 2.9 14.2 3.3 14.9 6.3 2.3 6.1 7.8 3.2 25.7 20.4 13.1 6.2 10.7 10.0 14.3 24.4 8.6 2.3 4.7 4.2 9.1 21.6 3.4 2.3 8.7 8.6 4.9 3.0 14.1 2.7 6.5 21.9 14.8 5.4 8.8 39.4 7.5 28.0 13.0 3.1 14.7 20.6 5.0 2.7 24.1 6.9 10.4 14.2 11.9 7.6 3.5 24.5 13.4 19.8 14.4 9.7 13.2 15.8 24.2 15.7 11.6 6.6 17.9 13.2 45.3 29.2 35.3 7.1 27.8 16.0 9.6 12.4 19.6 20.9 7.3 9.5 6.9 3.8 16.8 15.2 11.0 13.3 31.4 24.8 19.6 6.6 18.9 9.2 22.9 15.1 13.9 14.4 8.2 17.2 15.8 21.5 37.9 19.7 20.0 13.6 30.2 26.0 30.7 10.1 13.4 13.9 13.3 9.2 13.9 10.0 18.4 17.3 12.8 19.4 10.9 1.9 24.9 17.6 11.1 19.4 2.0 0.3 4.0 3.2 0.7 2.3 1.8 2.3 4.2 1.2 2.0 1.9 3.7 0.4 4.7 0.9 0.5 2.0 1.1 2.9 3.3 2.3 6.1 8.6 2.3 3.4 2.3 2.7 3.1 2.7 3.5 13.0 9.6 10.2 3.9 14.4 11.3 11.9 6.7 8.6 18.0 7.4 8.1 44.5 20.0 11.2 1.8 22.9 3.5 28.6 133.1 0.0 19.0 0.6 28.0 35.9 12.1 24.6 4.8 11.0 18.2 7.9 18.9 25.0 15.6 5.7 13.3 6.4 6.1 17.0 80.8 11.4 62.0 4.1 15.7 22.5 2.0 11.5 15.5 8.8 13.1 12.0 16.7 42.2 6.0 9.1 17.7 61.3 13.2 9.0 16.1 62.9 11.3 30.3 23.3 13.1 53.5 33.6 2.7 10.1 15.6 16.2 4.5 31.0 17.9 32.3 34.4 DYRK3 "hYAK3-2, RED, REDK" ENSG00000143479 "Dual specificity tyrosine phosphorylation regulated kinase 3" O43781 1 206635536-206684419 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 48.0" "Cell type enhanced" "Detected in many" "Early spermatids: 235.3;Late spermatids: 48.1;Spermatocytes: 108.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "plasmacytoid DC: 2.7" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "hTERT-HME1: 73.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA075041 Supported Nucleoplasm,Cytosol NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 30: Epithelial cell lines - Translation" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm Cytosol "HPA075041: AB_2686730" "unprognostic (6.51e-2)" "unprognostic (1.24e-2)" "unprognostic (3.36e-2)" "unprognostic (2.03e-1)" "unprognostic (2.81e-2)" "unprognostic (1.23e-1)" "unprognostic (1.20e-4)" "unprognostic (2.69e-1)" "unprognostic (3.91e-1)" "unprognostic (2.71e-1)" "unprognostic (2.79e-3)" "unprognostic (2.52e-1)" "prognostic unfavorable (9.41e-7)" "unprognostic (2.38e-1)" "unprognostic (2.04e-1)" "unprognostic (1.99e-2)" "unprognostic (7.62e-3)" 7.6 2.4 3.7 4.2 3.8 8.8 5.7 1.7 3.7 5.6 5.6 2.3 1.0 5.3 3.1 2.8 5.7 13.5 8.3 5.1 3.8 3.3 4.1 5.5 1.6 3.8 5.1 4.9 3.9 3.0 6.5 1.2 3.4 2.9 1.4 6.4 4.3 3.0 0.8 1.5 1.7 8.1 2.6 1.3 3.1 48.0 3.8 5.9 8.3 1.9 1.8 7.5 2.8 3.5 5.0 6.7 1.6 9.8 16.7 15.9 0.4 15.4 36.7 15.0 19.6 0.4 2.7 7.6 2.2 20.1 25.8 1.5 8.6 14.1 15.8 0.1 4.8 10.5 8.9 1.7 26.9 7.5 6.8 10.9 8.9 25.6 73.6 15.1 11.8 11.6 20.1 1.4 23.2 2.0 16.9 4.4 13.2 0.5 10.8 41.1 4.9 0.1 4.8 0.4 9.3 6.9 13.6 0.6 20.3 2.0 2.0 1.9 8.1 31.1 11.2 14.8 13.2 5.6 2.2 9.1 17.7 8.3 2.9 0.7 0.0 0.2 0.0 0.1 0.1 0.0 0.2 0.0 0.0 0.1 0.1 0.1 0.5 0.0 0.0 2.7 0.0 0.0 3.7 3.8 1.7 3.7 5.1 3.8 3.8 5.1 3.4 2.6 3.8 3.5 13.9 3.2 8.2 4.2 1.0 6.5 10.7 9.6 3.4 0.2 4.7 3.3 10.8 1.5 4.2 1.8 10.4 0.0 1.5 0.3 0.0 5.1 235.3 12.6 8.0 8.5 2.4 23.6 3.6 2.2 0.1 12.7 1.1 5.9 0.0 3.4 3.9 1.1 1.0 0.0 1.5 0.4 2.0 1.0 4.6 48.1 4.1 2.9 8.8 1.0 1.0 3.4 0.0 2.5 0.3 1.2 1.2 1.9 2.1 3.8 0.2 1.7 10.5 8.2 6.6 10.2 10.4 108.7 6.4 1.3 3.7 0.4 2.4 3.0 0.6 5.3 DYRK4 ENSG00000010219 "Dual specificity tyrosine phosphorylation regulated kinase 4" Q9NR20 12 4562204-4615302 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 36.7" "Group enriched" "Detected in all" 5 "Early spermatids: 392.2;Late spermatids: 393.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA028065, HPA056073" Enhanced Enhanced Vesicles No No "Cluster 14: Monocytes - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 34: Spermatids - Unknown function" Vesicles "HPA028065: AB_10601212, HPA056073: AB_2683028" "unprognostic (2.50e-1)" "unprognostic (1.55e-1)" "unprognostic (1.22e-1)" "unprognostic (3.56e-3)" "unprognostic (2.62e-1)" "unprognostic (4.07e-3)" "unprognostic (2.03e-2)" "unprognostic (4.69e-2)" "unprognostic (1.29e-1)" "unprognostic (7.13e-2)" "unprognostic (1.22e-2)" "unprognostic (2.46e-1)" "prognostic unfavorable (6.52e-6)" "unprognostic (1.86e-1)" "unprognostic (9.71e-2)" "unprognostic (1.04e-1)" "unprognostic (3.98e-2)" 2.1 4.2 3.9 3.4 4.2 4.6 6.4 5.1 7.6 5.9 4.2 5.4 4.6 5.0 17.0 4.0 5.0 4.4 4.7 4.2 4.4 3.5 4.2 4.7 5.9 4.4 4.5 5.1 3.0 5.0 3.6 6.8 4.8 5.0 6.2 7.7 3.7 7.2 2.2 4.9 4.0 5.1 4.1 6.2 3.2 36.7 4.8 4.3 9.1 4.1 5.4 4.7 2.0 5.7 2.0 3.2 3.9 4.3 5.8 7.1 4.7 2.4 4.8 5.4 5.9 0.6 3.2 6.1 0.3 6.9 3.7 4.2 3.0 4.5 4.2 4.7 6.8 4.2 1.0 3.6 16.4 3.7 3.3 4.9 9.6 3.8 12.4 10.1 7.8 6.5 1.8 6.7 4.9 4.3 3.5 9.1 5.3 1.0 1.8 0.7 2.8 2.6 6.7 1.9 0.0 1.5 0.5 2.4 3.3 8.4 1.9 3.3 0.5 6.3 4.9 0.6 3.1 1.9 2.6 3.8 3.3 5.8 3.3 0.3 1.7 0.8 0.5 1.3 0.6 4.4 0.8 0.9 1.6 3.0 0.8 0.9 0.0 0.7 3.5 0.8 0.7 0.8 3.9 4.2 5.1 7.6 4.2 4.4 4.4 4.5 4.8 4.1 4.8 5.7 13.0 12.8 16.2 11.1 15.8 8.9 13.2 31.2 14.8 20.7 21.2 30.4 23.8 7.2 19.9 16.5 10.4 15.7 16.7 5.2 31.3 25.1 392.2 14.0 22.5 15.5 5.4 12.2 10.3 27.1 12.0 17.3 14.3 13.3 17.7 19.0 8.2 9.8 49.7 13.5 10.4 75.4 14.2 16.1 9.3 393.1 15.2 18.7 16.0 9.4 14.5 19.4 13.4 14.1 16.1 20.1 14.2 31.6 22.9 16.4 7.3 35.6 13.9 21.7 6.6 15.2 17.6 23.7 39.0 20.4 7.5 9.9 12.7 40.6 17.3 11.8 DZIP3 "hRUL138, PPP1R66" ENSG00000198919 "DAZ interacting zinc finger protein 3" Q86Y13 3 108589705-108694840 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" "RNA-binding, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 327.4;Respiratory ciliated cells: 218.2;Spermatocytes: 351.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035066, HPA049232" Approved Approved Vesicles No No "Cluster 15: NK-cells - Transcription" "Cluster 77: Retina - Visual perception" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 49: Ciliated cells - Cilium organization" Vesicles "HPA035066: AB_10601549, HPA049232: AB_2680684" "unprognostic (1.14e-1)" "unprognostic (1.90e-1)" "unprognostic (7.68e-2)" "unprognostic (3.12e-2)" "unprognostic (2.15e-1)" "unprognostic (2.37e-2)" "unprognostic (3.33e-1)" "unprognostic (5.16e-2)" "unprognostic (2.74e-1)" "unprognostic (3.76e-2)" "unprognostic (2.59e-3)" "unprognostic (5.38e-2)" "prognostic favorable (3.65e-4)" "unprognostic (6.06e-2)" "unprognostic (2.78e-2)" "unprognostic (5.51e-3)" "unprognostic (3.81e-2)" 5.2 9.7 15.6 4.9 19.4 4.0 5.3 11.8 18.6 5.3 22.6 5.1 3.0 7.9 10.1 3.9 18.7 5.9 11.7 18.8 18.5 10.9 4.3 6.5 10.2 13.3 14.9 10.5 5.3 7.8 24.5 4.9 12.4 9.7 4.7 29.8 3.6 7.0 12.4 3.7 3.9 5.2 10.4 8.3 6.6 34.6 15.5 8.5 12.8 16.2 8.0 5.2 3.4 15.0 9.8 8.2 24.8 14.7 10.7 10.8 8.6 6.1 12.2 10.1 13.9 12.1 6.8 18.0 12.8 6.6 20.9 3.5 13.7 5.3 21.0 6.6 6.1 8.1 3.4 8.5 6.3 3.3 4.5 11.8 2.8 9.4 11.4 10.2 6.4 10.9 8.0 8.7 19.6 8.6 8.2 3.5 15.5 5.0 6.2 10.4 20.5 1.8 8.4 4.7 17.0 16.2 9.8 1.0 11.1 21.6 15.1 2.8 7.6 9.0 13.7 1.8 5.3 9.6 6.0 34.7 6.8 2.7 11.3 6.5 0.5 1.2 4.1 0.8 5.0 6.3 4.2 5.1 0.5 4.6 3.6 4.8 0.1 10.6 1.5 1.5 6.0 1.5 15.6 19.4 11.8 18.6 18.8 18.5 13.3 14.9 12.4 10.4 15.5 15.0 7.3 12.8 12.8 86.8 14.8 7.5 8.6 16.3 9.1 67.8 9.6 8.3 45.0 4.3 26.6 33.1 327.4 21.9 17.1 4.1 13.7 12.9 28.4 106.1 16.0 8.7 52.8 11.1 145.2 9.0 8.8 18.2 9.2 9.2 8.8 30.9 7.5 4.4 9.4 77.4 103.4 6.9 34.6 5.7 7.5 59.9 17.4 5.7 7.2 37.5 10.5 32.9 11.3 79.4 80.6 8.9 4.6 17.7 9.0 6.9 4.5 20.6 218.2 33.7 19.7 16.6 17.7 351.3 112.5 4.4 7.4 14.8 29.4 35.4 7.4 5.6 E4F1 E4F ENSG00000167967 "E4F transcription factor 1" Q66K89 16 2223580-2235742 "Enzymes, Predicted intracellular proteins, Transcription factors" "Cell cycle, Cell division, Growth regulation, Host-virus interaction, Mitosis, Transcription, Transcription regulation, Ubl conjugation pathway" "DNA-binding, Repressor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA052042, HPA069007, HPA071325, HPA072309" Enhanced Enhanced Nucleoplasm NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 72: Non-specific - Transcription" "Cluster 20: HeLa - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "HPA052042: AB_2681705, HPA069007: , HPA071325: AB_2686390, HPA072309: " "unprognostic (3.05e-1)" "prognostic favorable (9.13e-4)" "unprognostic (7.31e-2)" "unprognostic (4.57e-3)" "unprognostic (2.89e-1)" "prognostic favorable (1.10e-4)" "unprognostic (9.16e-2)" "unprognostic (4.23e-2)" "unprognostic (3.08e-1)" "unprognostic (1.87e-1)" "unprognostic (1.29e-2)" "unprognostic (8.49e-3)" "prognostic unfavorable (5.50e-4)" "unprognostic (1.85e-1)" "unprognostic (1.03e-1)" "unprognostic (5.12e-1)" "unprognostic (8.93e-3)" 13.5 16.0 7.9 6.6 8.6 11.3 15.1 10.2 13.5 17.5 4.8 16.5 6.2 18.7 1.9 16.1 15.2 3.3 15.3 8.1 7.0 16.1 19.0 13.4 6.8 10.2 8.1 15.9 15.2 4.4 19.0 5.3 10.0 21.3 1.8 3.0 16.0 5.5 19.0 23.6 15.0 2.7 6.1 20.5 14.8 14.4 8.3 6.4 22.6 4.3 2.8 16.1 16.4 9.4 10.9 20.2 8.3 16.4 4.8 4.4 20.0 14.8 6.6 10.0 6.7 32.7 16.2 15.8 15.8 5.7 5.6 14.6 6.8 7.6 1.8 17.2 25.6 11.2 36.1 18.0 9.3 14.2 19.1 6.6 8.5 9.0 4.1 5.6 6.9 13.5 26.7 10.6 3.8 30.1 18.8 30.6 18.7 6.6 18.8 34.7 9.1 27.9 6.2 7.6 21.4 15.5 18.4 21.9 10.7 3.0 19.4 20.0 12.3 12.0 15.7 12.0 12.4 20.7 10.9 32.0 5.0 10.0 12.3 6.8 8.1 11.7 10.2 9.8 8.8 8.2 8.4 9.7 8.8 8.0 9.0 8.4 11.4 6.9 11.8 5.2 11.4 7.5 7.9 8.6 10.2 13.5 8.1 7.0 10.2 8.1 10.0 6.1 8.3 9.4 9.1 16.0 8.2 8.5 14.4 7.1 7.9 12.2 9.1 13.8 12.3 10.8 4.9 5.7 13.9 11.0 37.5 20.4 18.5 26.5 11.7 11.1 19.6 12.6 10.2 10.3 25.8 6.5 8.1 10.5 17.2 8.7 31.1 11.6 2.5 12.3 6.8 10.5 12.6 30.3 7.2 19.8 20.3 7.3 7.8 5.0 11.5 7.3 7.2 10.3 9.1 11.3 13.4 5.0 5.5 11.1 14.5 16.1 13.2 9.7 15.4 8.0 12.0 15.7 13.1 9.6 11.2 19.0 16.1 7.6 8.9 13.4 11.8 12.6 15.3 6.4 EEF2K "CaMKIII, eEF-2K" ENSG00000103319 "Eukaryotic elongation factor 2 kinase" O00418 16 22206278-22288738 "Enzymes, Predicted intracellular proteins" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skin 1: 49.0" "Cell type enhanced" "Detected in many" "Bipolar cells: 69.1;Late spermatids: 76.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HaCaT: 1.5;HL-60: 1.6;HMC-1: 1.8;NB-4: 1.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007818, HPA056061" Approved Approved Nucleoplasm NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 31: Skin - Epidermis development" "Cluster 3: HMC-1 - Innate immune response" "Cluster 50: Fibroblasts - ECM organization" Nucleoplasm "CAB007818: AB_598150, HPA056061: AB_2683021" "unprognostic (4.79e-2)" "unprognostic (6.10e-1)" "unprognostic (3.89e-2)" "unprognostic (3.49e-1)" "unprognostic (1.94e-2)" "unprognostic (5.09e-3)" "unprognostic (1.40e-1)" "unprognostic (2.24e-2)" "unprognostic (1.74e-1)" "unprognostic (8.50e-2)" "unprognostic (2.01e-2)" "unprognostic (9.07e-3)" "prognostic unfavorable (2.38e-4)" "unprognostic (2.86e-1)" "unprognostic (1.11e-1)" "unprognostic (1.24e-1)" "unprognostic (1.80e-1)" 19.8 7.1 1.0 0.4 0.9 0.7 15.9 1.5 2.2 17.2 0.7 20.1 0.3 14.3 0.7 9.1 13.1 0.3 9.2 0.9 1.2 3.6 7.8 9.0 0.5 1.1 0.9 8.2 12.9 0.0 5.2 0.4 1.2 19.6 0.2 0.3 15.0 0.2 24.9 49.0 8.1 0.3 0.9 8.0 9.8 2.3 1.4 0.0 6.3 0.0 0.2 18.8 15.4 1.1 0.0 0.0 0.0 0.0 0.4 0.5 0.4 0.0 0.0 0.0 0.0 0.2 0.0 0.4 0.1 0.0 0.0 1.5 0.2 0.0 0.0 0.1 0.0 0.6 0.2 1.0 0.0 1.6 1.8 0.0 0.4 0.1 0.1 0.3 0.1 0.1 0.2 1.3 0.0 0.0 0.1 1.6 0.1 0.4 0.0 0.4 1.0 0.2 0.4 0.0 0.3 0.6 0.0 0.0 0.2 0.1 0.2 0.5 0.5 0.7 0.3 1.4 0.0 0.3 0.1 0.3 1.0 1.0 0.1 0.2 0.1 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.4 0.0 0.0 0.4 0.1 0.0 1.0 0.9 1.5 2.2 0.9 1.2 1.1 0.9 1.2 0.9 1.4 1.1 43.7 22.4 13.3 22.5 7.3 12.6 9.6 3.9 31.3 69.1 15.4 9.3 17.3 12.8 9.8 9.2 14.6 16.3 12.7 24.2 0.0 4.9 42.9 42.4 12.6 18.4 3.0 7.6 21.2 13.4 11.7 19.2 26.0 34.9 29.2 12.0 22.5 17.7 18.7 1.7 37.4 12.3 4.1 15.3 16.2 76.6 14.3 8.7 8.8 15.9 7.9 6.1 6.2 31.7 8.6 10.2 26.3 15.8 19.6 6.6 12.5 4.0 14.9 21.6 6.6 43.5 10.0 1.3 4.2 16.9 23.0 7.8 7.8 5.7 8.1 6.7 EGFR "ERBB, ERBB1" ENSG00000146648 "Epidermal growth factor receptor" P00533 7 55019017-55211628 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" "Host-virus interaction" "Developmental protein, Host cell receptor for virus entry, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 287.9;Skeletal myocytes: 251.2;Syncytiotrophoblasts: 376.8" "Cancer enhanced" "Detected in all" "glioma: 136.0" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in many" 13 "A-431: 5282.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000035, HPA001200, HPA018530, CAB068186, CAB073534" Enhanced Enhanced "Plasma membrane,Cell Junctions" "Secreted to blood" NA NA 4740000 88000000 "Cluster 31: Skin - Epidermis development" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 50: Fibroblasts - ECM organization" "Plasma membrane, Cell Junctions" "CAB000035: , CAB068186: AB_2665679, CAB073534: , HPA001200: AB_1078723, HPA018530: AB_1848044" "unprognostic (2.62e-2)" "unprognostic (9.56e-3)" "unprognostic (1.59e-1)" "unprognostic (7.51e-2)" "unprognostic (1.08e-1)" "unprognostic (1.27e-2)" "unprognostic (6.11e-2)" "unprognostic (4.88e-2)" "unprognostic (2.85e-2)" "unprognostic (3.30e-3)" "unprognostic (1.78e-3)" "unprognostic (1.04e-1)" "unprognostic (1.93e-3)" "unprognostic (6.98e-3)" "unprognostic (1.72e-1)" "unprognostic (6.62e-2)" "prognostic unfavorable (2.04e-5)" 27.9 11.4 12.6 4.0 18.3 0.0 20.0 16.6 9.7 20.4 10.5 12.2 5.7 11.4 10.3 23.5 13.9 9.0 7.1 6.3 10.3 11.6 35.3 14.9 2.5 10.4 19.0 15.1 15.8 3.5 2.9 67.9 8.9 16.2 10.7 10.2 22.1 15.0 10.9 51.0 9.5 9.3 7.5 5.1 11.1 4.2 22.6 12.8 20.6 20.6 8.3 14.7 24.1 6.3 5282.1 61.9 16.5 22.4 102.7 63.5 16.7 47.9 68.7 30.8 23.8 11.5 54.2 2.7 11.4 43.8 130.7 197.1 0.4 230.2 37.1 2.2 3.6 0.1 27.3 3.4 27.0 0.0 0.2 31.2 205.4 74.1 409.9 45.5 4.0 0.0 0.0 0.5 68.0 3.0 0.1 0.1 5.1 21.2 30.4 0.1 9.1 0.2 38.1 52.6 0.8 20.0 42.7 50.6 9.3 16.8 4.9 12.0 15.6 27.1 7.2 215.7 45.8 0.1 4.8 3.1 37.9 1.6 8.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.6 18.3 16.6 9.7 6.3 10.3 10.4 19.0 8.9 7.5 22.6 6.3 16.4 96.1 49.9 147.6 1.2 85.8 77.1 101.5 116.1 3.5 12.1 30.4 11.1 47.1 50.6 22.0 6.2 287.9 0.0 45.9 0.0 32.9 4.9 25.9 57.2 12.5 4.2 8.0 1.2 24.3 37.1 91.6 22.4 39.8 0.0 50.6 6.8 79.5 28.3 0.0 107.5 21.6 48.8 7.7 11.6 5.8 128.3 1.9 17.8 40.3 1.6 90.0 0.0 63.3 1.4 54.8 19.9 133.5 0.0 75.4 14.1 13.4 21.7 3.8 78.9 251.2 34.7 2.4 2.5 73.3 89.9 376.8 2.2 41.9 24.9 55.8 EIF2AK1 "HRI, KIAA1369" ENSG00000086232 "Eukaryotic translation initiation factor 2 alpha kinase 1" Q9BQI3 7 6022247-6059175 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Protein synthesis inhibitor, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 4 "Cytotrophoblasts: 219.1;Erythroid cells: 422.0;Syncytiotrophoblasts: 371.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016496, CAB022082, HPA061675" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 6: Erythroid cells - Oxygen transport" Nucleoplasm Cytosol "CAB022082: , HPA016496: AB_1848057, HPA061675: AB_2684583" "unprognostic (7.15e-3)" "unprognostic (2.00e-2)" "unprognostic (1.45e-1)" "unprognostic (2.91e-1)" "unprognostic (6.70e-2)" "unprognostic (9.69e-3)" "prognostic unfavorable (6.99e-4)" "unprognostic (2.36e-1)" "unprognostic (2.54e-1)" "unprognostic (1.07e-2)" "unprognostic (1.48e-1)" "unprognostic (8.96e-2)" "unprognostic (2.53e-1)" "unprognostic (1.99e-1)" "unprognostic (5.45e-2)" "unprognostic (9.02e-2)" "unprognostic (1.06e-2)" 27.2 39.4 28.1 27.7 28.9 105.9 35.9 30.6 36.1 29.0 34.9 48.8 37.1 25.0 37.4 30.4 31.0 23.8 33.8 28.1 30.6 43.8 65.1 30.3 35.2 30.5 28.9 29.3 44.3 78.0 25.9 52.3 31.6 35.0 47.3 29.0 46.8 24.2 38.3 33.3 37.2 23.8 29.1 26.6 49.1 19.5 29.8 43.6 39.3 34.4 40.4 27.2 22.4 33.7 144.5 90.5 71.2 108.8 66.4 59.6 92.4 73.0 66.8 64.2 80.8 83.7 96.2 112.5 77.4 81.3 115.5 100.4 93.1 67.1 82.2 69.8 140.3 115.9 91.6 127.3 54.3 100.8 102.0 48.1 82.8 60.7 64.9 67.7 69.4 88.1 189.0 106.8 61.4 146.5 55.6 128.6 88.5 84.6 99.7 120.0 74.6 134.0 82.3 70.3 87.3 156.5 139.3 186.6 63.8 98.6 141.0 122.4 65.9 37.0 134.2 65.3 78.2 106.5 114.8 115.6 73.9 129.8 108.7 11.1 6.9 17.3 8.2 5.5 5.6 12.3 6.5 9.3 6.9 9.5 7.5 6.6 3.7 10.2 6.2 6.0 8.9 4.8 28.1 28.9 30.6 36.1 28.1 30.6 30.5 28.9 31.6 29.1 29.8 33.7 23.1 38.5 43.7 14.4 42.8 23.8 34.9 34.3 41.5 29.7 52.5 34.9 49.6 45.8 37.7 44.1 16.7 219.1 52.5 57.1 66.5 55.0 8.8 59.5 42.3 27.5 38.5 422.0 21.8 44.8 82.1 29.7 64.7 48.1 20.8 44.9 21.0 63.2 53.8 32.0 21.9 68.7 54.9 39.0 29.9 16.1 34.5 65.2 24.9 13.1 62.8 46.4 70.0 19.1 26.9 53.0 47.0 37.6 60.1 43.3 47.5 66.1 48.3 26.5 13.1 32.0 26.0 33.7 34.5 45.5 22.4 371.0 38.0 57.1 52.7 32.3 EIF2AK2 "EIF2AK1, PKR, PPP1R83, PRKR" ENSG00000055332 "Eukaryotic translation initiation factor 2 alpha kinase 2" P19525 2 37099210-37157522 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Antiviral defense, Host-virus interaction, Immunity, Innate immunity, Transcription, Transcription regulation" "Kinase, RNA-binding, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003845, HPA019795, HPA063893" Approved Enhanced Cytosol NA NA 44000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Cytosol "CAB003845: AB_562332, HPA019795: AB_1848060, HPA063893: AB_2685144" "unprognostic (1.70e-2)" "unprognostic (2.26e-1)" "unprognostic (1.62e-1)" "prognostic unfavorable (3.77e-4)" "unprognostic (1.66e-1)" "unprognostic (1.04e-1)" "unprognostic (1.77e-3)" "unprognostic (8.42e-2)" "unprognostic (8.02e-2)" "unprognostic (4.67e-2)" "prognostic unfavorable (2.08e-4)" "unprognostic (1.19e-1)" "unprognostic (3.15e-3)" "unprognostic (3.33e-1)" "unprognostic (1.74e-1)" "unprognostic (4.65e-2)" "unprognostic (5.32e-2)" 11.1 9.0 7.2 10.5 8.1 30.1 8.6 7.4 9.5 9.8 8.6 8.8 7.6 10.5 8.0 6.3 8.3 9.5 6.3 7.8 11.1 8.5 7.7 8.9 8.0 10.9 8.1 10.8 7.4 11.1 6.6 11.2 10.9 10.1 8.6 6.6 17.7 8.4 4.5 4.6 9.9 11.1 15.6 11.9 9.5 3.3 13.0 11.7 10.0 5.8 7.1 8.0 5.9 8.7 38.4 22.1 16.7 17.4 21.5 28.3 20.1 21.2 29.1 56.3 41.1 23.0 23.2 27.4 27.0 29.8 66.2 27.4 24.2 27.1 29.5 45.7 12.0 33.8 19.2 18.7 17.9 32.2 0.2 22.5 13.1 23.7 19.3 17.7 18.0 10.7 19.1 23.6 20.3 13.4 35.5 17.0 15.8 8.4 10.8 27.6 40.9 12.1 15.3 18.7 14.1 20.4 32.0 24.0 50.7 12.7 9.2 9.0 31.4 25.7 24.9 15.1 36.2 19.0 30.8 0.3 15.9 20.0 23.1 10.7 5.3 6.3 5.4 7.9 5.2 5.3 4.5 5.2 4.8 4.2 3.0 4.3 15.7 6.5 8.0 3.1 6.5 2.1 7.2 8.1 7.4 9.5 7.8 11.1 10.9 8.1 10.9 15.6 13.0 8.7 94.5 67.3 34.0 25.1 35.9 19.5 42.3 33.0 31.3 38.8 26.6 26.0 29.9 32.9 46.0 22.0 14.6 47.8 44.8 32.2 21.5 40.2 2.4 55.8 68.7 76.3 15.0 36.0 39.6 48.5 89.2 52.6 22.4 41.7 41.1 93.5 33.5 21.9 38.2 47.1 42.9 24.0 16.2 29.9 20.8 4.2 57.2 50.7 21.4 48.7 47.1 50.9 45.3 51.3 16.8 54.7 21.8 84.2 46.0 39.5 33.6 33.0 48.9 24.8 39.5 60.5 45.9 2.4 5.5 22.5 10.1 40.8 40.0 61.3 28.6 40.5 EIF2AK3 "PEK, PERK" ENSG00000172071 "Eukaryotic translation initiation factor 2 alpha kinase 3" Q9NZJ5 2 88556741-88627464 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Stress response, Translation regulation, Unfolded protein response" "Kinase, Serine/threonine-protein kinase, Transferase" "Diabetes mellitus, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "pancreas: 19.6" "Cell type enhanced" "Detected in many" "Plasma cells: 121.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in some" "naive B-cell: 1.9" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "Daudi: 46.8;U-266/70: 44.0;U-698: 31.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009204, HPA015737" Approved NA NA "Cluster 24: B-cells - Unknown function" "Cluster 25: Pancreas - Digestion" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 55: Plasma cells - Humoral immune response" "CAB009204: AB_2230863, HPA015737: AB_1848062" "unprognostic (7.25e-3)" "unprognostic (5.35e-2)" "unprognostic (3.03e-3)" "unprognostic (9.32e-2)" "unprognostic (9.39e-3)" "unprognostic (3.25e-2)" "unprognostic (2.27e-2)" "unprognostic (3.46e-3)" "unprognostic (9.84e-2)" "unprognostic (3.50e-1)" "unprognostic (1.89e-1)" "unprognostic (2.31e-1)" "unprognostic (2.06e-1)" "unprognostic (2.92e-1)" "unprognostic (9.80e-2)" "unprognostic (3.60e-3)" "unprognostic (2.90e-3)" 3.3 3.1 0.8 4.0 1.1 2.6 1.6 1.6 1.4 2.3 1.6 4.7 6.2 1.9 1.0 1.6 1.3 1.4 1.5 0.8 1.5 2.0 1.9 1.8 3.2 1.0 1.2 1.9 19.6 3.4 1.1 3.2 0.9 4.0 1.8 0.1 9.7 1.2 2.0 1.4 5.0 0.9 1.5 3.1 12.3 1.0 1.2 1.3 3.5 0.0 2.3 1.9 1.8 2.1 8.7 3.3 1.2 4.3 2.8 2.0 15.9 12.4 1.1 0.7 2.1 3.5 2.9 46.8 8.0 1.3 3.1 7.2 1.6 1.3 1.1 25.3 7.1 4.6 1.7 2.0 1.1 3.9 12.3 0.1 1.5 0.7 2.0 0.8 1.4 4.9 3.0 8.7 0.6 4.4 5.5 2.2 6.2 2.7 7.2 25.1 7.0 8.2 1.3 5.0 5.6 9.9 6.3 6.5 8.2 1.7 2.2 4.4 3.9 2.5 5.5 10.8 7.1 44.0 24.4 31.0 4.6 4.2 6.2 0.0 0.1 0.1 0.3 0.0 0.2 1.0 0.2 0.8 0.1 1.9 0.2 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.8 1.1 1.6 1.4 0.8 1.5 1.0 1.2 0.9 1.5 1.2 2.1 9.2 9.6 7.5 14.7 43.8 20.3 8.9 7.2 26.7 8.4 14.7 8.9 8.2 17.2 7.2 12.9 8.4 4.1 13.4 14.0 0.0 3.7 0.1 18.4 18.3 7.6 13.7 1.7 31.3 6.5 6.9 15.2 40.2 39.2 1.3 4.4 8.9 11.8 4.6 1.7 39.0 30.1 14.2 5.1 41.2 0.7 7.5 27.7 32.0 21.5 3.9 3.0 9.2 20.1 26.2 7.0 7.7 5.7 121.3 13.0 5.4 2.9 7.7 2.3 0.0 13.4 9.4 3.1 3.6 23.8 18.3 6.7 12.8 3.5 6.8 16.6 EIF2AK4 "GCN2, KIAA1338" ENSG00000128829 "Eukaryotic translation initiation factor 2 alpha kinase 4" Q9P2K8 15 39934115-40035591 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Activation of host autophagy by virus, Adaptive immunity, Antiviral defense, Cell cycle, Growth arrest, Host-virus interaction, Immunity, Neurogenesis, Stress response, Translation regulation" "Activator, Kinase, RNA-binding, Serine/threonine-protein kinase, Transferase, tRNA-binding" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "plasmacytoid DC: 66.5" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA011811 Approved Approved Cytosol NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 15: Liver - Metabolism" "Cluster 44: HDLM-2 - Immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Cytosol "HPA011811: AB_2668543" "unprognostic (3.10e-1)" "unprognostic (4.78e-3)" "unprognostic (5.97e-2)" "unprognostic (7.18e-2)" "unprognostic (1.05e-2)" "unprognostic (3.32e-2)" "unprognostic (1.18e-1)" "unprognostic (3.18e-1)" "unprognostic (1.36e-1)" "unprognostic (1.21e-1)" "unprognostic (1.38e-2)" "unprognostic (7.27e-2)" "unprognostic (2.38e-1)" "unprognostic (1.27e-2)" "unprognostic (6.47e-2)" "unprognostic (2.31e-2)" "unprognostic (5.11e-3)" 20.1 14.6 21.5 12.2 22.4 18.7 17.6 27.2 23.7 14.6 16.8 15.5 11.3 30.5 15.4 16.0 16.1 17.0 17.7 21.2 22.0 13.4 21.3 16.9 16.9 20.3 20.2 17.1 14.1 17.7 24.1 19.0 20.5 19.8 12.9 13.1 13.9 11.5 18.9 19.0 11.3 15.6 18.9 15.7 15.2 8.9 22.1 13.1 21.8 11.0 11.6 17.2 12.4 28.9 37.1 17.5 30.3 46.3 49.0 81.7 28.9 51.0 58.1 40.8 40.0 25.2 15.6 19.6 25.9 69.3 54.7 38.6 41.1 61.4 56.6 92.8 20.4 41.6 30.8 30.7 42.1 25.6 27.8 65.3 41.2 39.0 69.8 57.3 58.0 40.5 31.3 18.1 81.7 12.3 21.7 34.6 18.8 32.8 38.2 25.4 42.2 33.1 51.4 24.7 16.1 24.4 36.4 22.2 32.3 29.5 30.7 43.4 61.6 54.3 40.9 27.3 33.6 24.6 47.8 6.0 38.1 34.4 77.4 11.6 10.8 8.6 6.8 14.1 5.7 7.1 7.6 7.9 17.6 9.2 8.3 8.2 3.3 8.5 20.5 66.5 5.8 4.9 21.5 22.4 27.2 23.7 21.2 22.0 20.3 20.2 20.5 18.9 22.1 28.9 47.9 16.0 31.1 28.7 29.3 12.0 27.5 17.8 43.3 29.9 45.0 45.2 32.3 32.9 21.4 16.5 12.5 37.5 32.2 21.1 13.7 23.7 1.5 19.3 52.7 35.3 14.4 37.4 42.7 25.4 34.8 36.5 23.4 27.0 24.1 35.0 22.9 27.8 30.7 28.6 53.9 25.9 12.2 33.7 55.4 4.3 42.3 52.1 32.0 29.0 41.1 30.4 16.5 30.2 26.3 47.6 16.2 39.9 115.6 30.7 6.4 18.2 12.9 23.9 46.0 43.6 35.6 8.6 29.8 47.0 14.5 15.2 18.2 64.0 29.6 18.4 ELOVL1 Ssc1 ENSG00000066322 "ELOVL fatty acid elongase 1" Q9BW60 1 43363398-43368074 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" Transferase "Disease variant, Ichthyosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033426, HPA056557" Enhanced Supported "Endoplasmic reticulum" NA Yes "Cluster 31: Non-specific - Inflammatory response" "Cluster 27: Brain & Skin - Unknown function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 30: Mammary glandular cells - Lactation" "Endoplasmic reticulum" "CAB033426: AB_2099896, HPA056557: AB_2683173" "unprognostic (5.23e-2)" "prognostic unfavorable (3.63e-5)" "unprognostic (8.00e-2)" "unprognostic (8.45e-2)" "unprognostic (7.60e-2)" "unprognostic (7.40e-2)" "prognostic unfavorable (2.79e-7)" "unprognostic (4.74e-2)" "unprognostic (1.33e-1)" "unprognostic (4.37e-1)" "prognostic unfavorable (8.51e-4)" "unprognostic (1.83e-1)" "unprognostic (2.88e-2)" "unprognostic (1.41e-2)" "unprognostic (1.28e-1)" "unprognostic (1.73e-1)" "unprognostic (9.00e-2)" 78.5 54.7 77.2 39.8 115.6 52.9 66.6 121.1 116.9 57.1 61.4 63.9 51.6 46.5 30.6 176.6 38.9 42.4 47.2 76.8 93.2 59.7 45.8 59.6 40.1 152.0 110.1 28.9 55.4 46.2 27.2 51.0 140.7 58.7 48.6 8.4 72.7 48.8 24.1 201.9 55.4 50.8 114.8 57.1 70.6 18.6 107.7 22.2 66.8 28.0 55.7 68.5 86.8 165.7 108.0 119.5 22.6 44.8 148.4 138.2 70.2 125.2 154.5 153.5 122.4 105.9 182.5 73.9 94.3 193.6 130.3 119.4 79.7 152.2 93.2 94.6 53.9 96.6 77.3 77.1 128.2 84.2 98.0 106.2 168.2 180.9 198.4 114.8 155.0 27.7 68.1 54.8 178.5 79.5 19.9 69.5 33.5 136.9 120.2 43.6 59.9 89.7 195.5 128.7 27.4 28.8 73.7 258.4 105.8 66.8 121.2 82.4 132.2 129.7 82.5 161.2 161.3 26.6 31.2 35.4 127.8 85.2 120.1 134.9 189.6 172.7 105.1 180.0 93.4 109.0 98.4 103.2 212.8 94.2 63.5 88.0 133.0 114.7 179.6 148.8 113.8 203.1 77.2 115.6 121.1 116.9 76.8 93.2 152.0 110.1 140.7 114.8 107.7 165.7 44.0 19.2 12.5 7.5 28.1 15.6 25.9 61.1 29.6 5.7 60.3 37.5 4.7 34.3 40.2 40.5 10.4 93.4 36.0 114.0 7.9 91.5 3.4 22.9 26.3 43.6 19.2 67.8 3.8 100.1 127.4 26.1 48.4 45.2 21.0 52.6 24.7 16.7 74.9 3.3 3.4 33.8 46.8 46.3 37.5 4.6 20.2 41.5 12.4 7.5 92.5 13.7 32.0 3.0 66.1 133.3 63.9 25.6 19.0 44.7 66.0 23.3 14.5 9.5 19.7 10.0 39.7 8.4 11.2 70.1 31.0 95.9 31.5 50.8 47.2 49.2 ELOVL2 Ssc2 ENSG00000197977 "ELOVL fatty acid elongase 2" Q9NXB9 6 10980759-11044305 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 52.5;placenta: 35.3;retina: 27.9" "Cell type enhanced" "Detected in many" "Astrocytes: 95.0;Cone photoreceptor cells: 29.2;Extravillous trophoblasts: 19.7;Sertoli cells: 19.7;Spermatocytes: 23.0" "Group enriched" "Detected in many" 8 "breast cancer: 11.9;glioma: 25.8;liver cancer: 24.0;melanoma: 14.2;prostate cancer: 9.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ hTERT+ SV40 Large T+ RasG12V: 29.9;GAMG: 31.2;HBF TERT88: 29.0;Hep G2: 23.4;RH-30: 31.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 15: Liver - Metabolism" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 33: Fibroblasts - ECM organization" "prognostic favorable (6.73e-5)" "unprognostic (4.20e-1)" "unprognostic (1.64e-1)" "unprognostic (1.28e-5)" "unprognostic (4.06e-2)" "unprognostic (4.09e-3)" "unprognostic (1.89e-1)" "unprognostic (5.73e-2)" "unprognostic (1.63e-1)" "unprognostic (2.56e-1)" "unprognostic (6.92e-3)" "unprognostic (1.78e-2)" "unprognostic (1.04e-12)" "unprognostic (9.98e-4)" "unprognostic (8.86e-2)" "unprognostic (3.41e-1)" "unprognostic (9.47e-2)" 1.2 0.9 8.6 1.5 10.7 0.0 4.8 10.0 13.9 0.2 4.0 0.5 0.2 0.5 2.3 0.4 0.2 0.6 3.2 9.0 8.8 0.2 52.5 0.2 0.5 10.6 9.3 0.2 2.6 9.7 2.9 35.3 9.8 5.3 0.1 27.9 0.7 0.4 1.0 0.2 0.3 0.7 9.6 0.0 0.1 11.5 8.8 1.1 1.8 0.9 0.9 2.0 0.1 14.1 0.0 5.3 20.1 0.0 0.0 0.0 11.5 0.4 1.0 17.7 29.9 0.0 0.0 0.0 0.0 1.1 31.2 0.0 21.3 0.0 29.0 0.0 18.2 0.1 0.4 23.4 0.9 0.4 4.8 0.2 0.0 13.7 0.0 1.0 0.0 0.9 1.2 0.0 0.4 0.1 12.1 0.2 3.8 0.0 17.4 16.6 31.8 0.0 0.0 0.3 8.0 9.1 0.0 0.0 7.5 16.1 3.7 9.3 0.0 0.0 0.0 0.0 7.4 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.6 10.7 10.0 13.9 9.0 8.8 10.6 9.3 9.8 9.6 8.8 14.1 0.5 0.0 0.0 95.0 0.1 0.1 0.0 0.0 0.0 2.2 7.8 1.3 1.2 8.6 0.0 0.0 29.2 2.3 0.0 0.0 0.0 7.2 10.1 0.0 0.5 1.9 0.0 0.0 2.5 1.0 19.7 8.0 0.0 0.0 0.0 0.3 0.0 17.5 1.2 0.0 5.9 0.0 0.0 0.0 0.0 14.9 0.9 0.1 0.0 6.5 0.0 4.9 0.0 4.5 16.8 1.0 0.0 0.4 0.0 1.9 0.0 0.1 0.0 11.8 19.7 0.1 3.9 23.0 8.9 0.2 0.0 1.6 0.1 0.0 0.0 0.1 ELOVL3 CIG-30 ENSG00000119915 "ELOVL fatty acid elongase 3" Q9HB03 10 102226299-102229589 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 9 "skin 1: 30.5" "Cell type enhanced" "Detected in some" "Adipocytes: 2.5;Breast myoepithelial cells: 3.2;Skeletal myocytes: 5.0;Spermatogonia: 3.4;Theca cells: 2.2" "Cancer enhanced" "Detected in many" "testis cancer: 10.6" "Low region specificity" "Detected in some" "Group enriched" "Detected in some" 10 "classical monocyte: 7.1;intermediate monocyte: 2.4;myeloid DC: 2.0;non-classical monocyte: 5.9" "Group enriched" "Detected in many" 10 "dendritic cells: 2.0;monocytes: 7.1" "Cell line enhanced" "Detected in many" "ASC diff: 9.5;ASC TERT1: 9.4;HSkMC: 13.9;NB-4: 11.6;SiHa: 22.6" "Not detected" "Not detected" "Not detected" "Not detected" HPA036236 Enhanced Approved Vesicles,Cytosol NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 61: Skin - Cornification" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 7: Non-specific - Mitochondria" "Vesicles, Cytosol" "HPA036236: AB_10601550" "unprognostic (1.52e-2)" "unprognostic (6.76e-2)" "unprognostic (1.84e-2)" "prognostic unfavorable (6.25e-5)" "unprognostic (8.23e-3)" "unprognostic (9.82e-2)" "unprognostic (2.17e-4)" "unprognostic (4.27e-2)" "unprognostic (2.28e-1)" "unprognostic (5.56e-2)" "unprognostic (1.84e-2)" "unprognostic (5.36e-3)" "unprognostic (2.66e-9)" "unprognostic (1.04e-1)" "unprognostic (2.81e-1)" "unprognostic (1.97e-1)" "unprognostic (1.79e-1)" 3.2 0.7 1.0 0.3 0.8 1.8 3.5 0.5 1.3 0.1 0.3 0.1 0.0 0.1 0.2 0.2 0.2 0.2 0.2 1.0 0.4 0.8 0.0 1.0 0.1 0.4 0.9 0.1 0.0 0.1 0.0 0.9 0.4 0.2 0.1 0.1 0.3 0.1 0.2 30.5 0.2 0.0 0.4 0.8 0.1 1.2 0.4 0.0 0.0 0.3 0.0 0.2 0.3 0.5 3.2 0.2 0.2 7.8 9.5 9.4 2.8 0.1 0.3 0.4 0.5 0.5 3.0 0.0 0.3 0.0 0.0 0.1 5.9 0.1 0.5 0.0 0.0 0.2 0.4 0.8 0.3 0.0 0.1 13.9 1.6 3.6 0.0 0.0 0.0 0.9 0.1 3.5 0.8 0.0 0.0 11.6 0.1 1.1 1.0 0.0 5.1 0.0 2.0 0.1 0.0 0.4 22.6 0.9 0.7 0.6 8.1 2.7 0.0 1.5 0.0 0.3 0.3 0.5 7.2 0.0 3.4 6.5 0.0 0.0 7.1 0.0 0.0 2.4 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.4 0.0 5.9 0.0 0.0 1.7 1.0 0.8 0.5 1.3 1.0 0.4 0.4 0.9 0.4 0.4 0.4 0.5 2.5 0.0 1.1 0.0 0.2 0.4 0.5 0.6 0.6 0.0 1.1 3.2 0.3 0.0 0.5 0.0 0.0 0.0 1.1 0.2 0.0 0.1 0.0 0.0 1.3 1.9 0.0 0.0 0.3 0.0 0.7 1.3 0.0 0.2 0.0 0.0 1.4 0.4 0.2 0.0 0.0 0.2 0.0 1.5 0.8 0.0 0.0 0.7 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.1 0.0 0.1 0.1 0.0 0.0 5.0 1.2 0.1 3.4 0.6 0.1 0.3 0.3 2.2 0.2 0.1 ELOVL4 "CT118, SCA34, STGD2, STGD3" ENSG00000118402 "ELOVL fatty acid elongase 4" Q9GZR5 6 79914814-79947553 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" Transferase "Disease variant, FDA approved drug targets, Ichthyosis, Mental retardation, Neurodegeneration, Spinocerebellar ataxia, Stargardt disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 105.5;retina: 176.7" "Cell type enhanced" "Detected in many" "Bipolar cells: 63.8;Cone photoreceptor cells: 148.0;Excitatory neurons: 55.3;Rod photoreceptor cells: 355.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 6 "MAIT T-cell: 23.7" "Lineage enriched" "Detected in single" 238 "T-cells: 23.7" "Cell line enhanced" "Detected in many" "JURKAT: 41.2;MOLT-4: 32.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 46: Photoreceptor cells - Phototransduction" "unprognostic (1.67e-2)" "unprognostic (8.58e-3)" "unprognostic (2.38e-2)" "unprognostic (3.08e-6)" "unprognostic (1.49e-1)" "unprognostic (2.10e-1)" "unprognostic (1.27e-1)" "unprognostic (1.39e-1)" "unprognostic (1.85e-1)" "unprognostic (3.46e-1)" "unprognostic (6.91e-3)" "unprognostic (3.39e-1)" "unprognostic (1.38e-2)" "unprognostic (3.45e-3)" "unprognostic (1.66e-1)" "unprognostic (1.77e-1)" "prognostic unfavorable (6.27e-4)" 0.7 2.0 7.1 1.1 7.0 0.1 4.1 10.0 15.4 3.5 9.7 1.8 0.6 2.2 1.0 10.6 0.7 1.6 0.9 7.8 9.9 1.5 0.1 0.3 0.4 14.4 5.3 1.7 0.5 10.8 6.4 1.7 15.0 4.0 1.0 176.7 2.8 1.7 0.2 43.1 0.8 2.7 4.3 0.5 0.9 5.7 7.4 105.5 1.5 0.5 1.7 1.2 4.0 7.2 0.0 0.8 10.8 12.0 8.8 8.5 1.6 5.6 6.1 4.7 10.2 1.5 0.0 0.0 1.0 7.7 19.3 1.1 14.1 7.9 3.5 0.0 18.2 0.4 2.2 0.0 8.1 4.4 1.7 6.9 2.9 4.8 4.9 6.8 7.8 41.2 0.0 0.0 10.0 1.9 32.8 0.0 10.4 0.0 5.6 0.0 15.5 0.0 0.1 0.0 14.2 4.2 6.0 9.6 1.7 7.4 3.8 0.3 0.8 2.1 4.1 3.2 4.3 7.2 15.3 0.0 5.0 0.0 3.3 0.0 0.0 0.0 2.3 0.0 23.7 0.0 3.3 3.9 0.0 0.0 0.6 1.6 0.0 0.0 0.0 0.0 0.2 0.9 7.1 7.0 10.0 15.4 7.8 9.9 14.4 5.3 15.0 4.3 7.4 7.2 0.7 0.0 0.0 7.5 0.2 11.3 2.3 7.5 15.4 63.8 0.7 1.7 0.9 0.0 3.9 0.0 148.0 0.9 1.7 0.0 0.0 0.1 6.3 0.3 7.0 2.2 8.9 0.0 55.3 0.0 1.5 6.5 0.0 0.1 0.0 1.5 0.0 0.0 0.2 42.1 53.0 0.5 6.1 0.3 1.5 2.1 1.2 0.2 3.6 8.4 0.1 50.7 0.0 20.1 8.6 0.0 1.1 3.4 0.3 3.1 0.0 2.3 0.5 355.3 0.0 2.0 4.3 15.4 15.4 14.8 37.8 1.0 2.6 1.3 0.2 0.7 ELOVL5 "dJ483K16.1, HELO1, SCA38" ENSG00000012660 "ELOVL fatty acid elongase 5" Q9NYP7 6 53267398-53349179 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" Transferase "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017042, HPA047752, HPA054197" Enhanced Enhanced "Endoplasmic reticulum" NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 35: Glandular cells - Unknown function" "Endoplasmic reticulum" "CAB017042: , HPA047752: AB_2680147, HPA054197: AB_2682413" "unprognostic (7.33e-2)" "unprognostic (5.80e-2)" "unprognostic (1.04e-1)" "unprognostic (1.92e-2)" "unprognostic (1.16e-1)" "unprognostic (5.01e-2)" "unprognostic (3.06e-1)" "unprognostic (2.19e-1)" "unprognostic (4.38e-2)" "unprognostic (1.43e-2)" "unprognostic (3.23e-1)" "unprognostic (6.40e-2)" "prognostic unfavorable (1.94e-6)" "unprognostic (1.58e-1)" "unprognostic (5.12e-2)" "prognostic unfavorable (6.80e-4)" "unprognostic (2.76e-2)" 242.4 134.7 51.3 74.9 67.0 114.6 199.2 74.6 79.2 48.9 49.4 40.0 28.3 39.8 49.7 28.4 46.0 51.3 37.8 50.8 65.3 38.9 108.9 68.4 106.7 80.7 69.0 32.3 15.4 24.3 28.5 40.2 74.5 128.0 18.3 36.5 24.8 103.0 9.9 32.9 47.5 52.4 67.7 56.1 22.8 82.5 65.8 107.3 45.1 19.5 102.4 67.1 27.0 98.9 137.2 98.1 168.0 309.0 436.0 250.8 71.3 155.8 174.2 123.2 171.5 87.4 154.5 154.4 110.3 163.3 193.1 78.9 168.0 142.6 183.7 131.2 117.5 153.1 85.0 122.9 239.0 122.2 107.2 233.6 109.8 123.6 153.9 124.5 139.1 301.4 194.2 87.3 90.3 14.9 364.4 107.9 91.2 5.2 73.6 139.9 115.3 54.3 232.7 80.6 155.7 107.1 129.3 66.9 135.2 108.7 152.3 112.9 133.0 134.7 118.5 242.2 208.8 72.8 72.1 116.2 70.2 173.6 97.8 47.6 49.2 183.7 34.9 34.9 56.5 88.4 58.1 42.7 77.9 101.5 27.8 26.3 261.5 36.7 45.0 20.4 110.0 50.6 51.3 67.0 74.6 79.2 50.8 65.3 80.7 69.0 74.5 67.7 65.8 98.9 48.6 80.1 50.7 75.4 118.3 52.4 108.2 36.8 44.3 11.6 177.3 70.9 23.3 21.5 40.2 12.9 2.1 25.3 55.5 2.1 15.6 34.9 94.2 37.4 53.2 54.4 25.0 77.0 25.8 36.1 58.2 54.8 3.1 66.4 99.0 28.4 39.3 88.7 35.5 8.4 29.8 1.6 16.2 57.3 114.6 181.0 20.8 55.5 48.0 39.4 53.5 83.2 39.1 49.3 111.2 27.8 1.4 32.0 45.2 169.2 21.9 48.4 58.5 6.0 65.7 27.3 77.5 27.0 18.9 35.7 60.9 31.2 97.2 60.0 4.4 73.4 ELOVL6 "FLJ23378, LCE, MGC5487" ENSG00000170522 "ELOVL fatty acid elongase 6" Q9H5J4 4 110045846-110199199 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 36.2" "Cell type enhanced" "Detected in many" "Excitatory neurons: 83.4;Hepatocytes: 102.0;Inhibitory neurons: 78.5;Oligodendrocytes: 77.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 6 "gdT-cell: 2.4;MAIT T-cell: 2.6;memory CD4 T-cell: 1.0;memory CD8 T-cell: 1.3;naive CD8 T-cell: 1.0;NK-cell: 3.3" "Group enriched" "Detected in many" 21 "NK-cells: 3.3;T-cells: 2.6" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA042355 Uncertain NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 15: Hepatocytes - Hemostasis" "HPA042355: AB_10796577" "unprognostic (3.92e-2)" "unprognostic (9.47e-2)" "prognostic favorable (6.74e-4)" "unprognostic (8.09e-2)" "unprognostic (2.06e-2)" "unprognostic (1.08e-3)" "unprognostic (4.16e-1)" "unprognostic (3.01e-3)" "unprognostic (4.03e-1)" "unprognostic (1.47e-1)" "unprognostic (2.33e-1)" "unprognostic (1.90e-2)" "unprognostic (2.28e-2)" "unprognostic (1.21e-1)" "unprognostic (2.12e-1)" "unprognostic (1.86e-1)" "unprognostic (5.32e-2)" 12.2 8.7 4.6 2.9 5.2 4.0 7.4 5.2 7.9 4.2 1.5 11.5 8.5 3.1 2.1 18.0 2.1 3.2 4.2 4.9 5.0 4.0 36.2 3.1 0.7 5.8 5.4 1.5 2.0 6.4 4.0 1.7 6.0 1.9 10.2 12.1 4.1 2.3 1.0 15.3 6.3 3.7 5.8 1.6 13.6 0.9 5.3 1.8 1.8 0.5 2.3 6.8 5.7 7.8 24.1 14.5 57.8 12.9 31.6 32.6 24.6 16.8 9.5 6.4 16.4 7.6 45.5 2.5 1.3 13.3 22.0 21.5 46.8 52.2 13.6 9.5 14.8 33.9 17.3 17.9 19.6 30.4 18.8 30.0 10.2 34.9 13.5 21.5 11.9 3.4 33.8 57.0 12.6 10.5 7.1 2.6 25.0 15.3 7.2 4.3 24.1 7.2 37.2 20.3 11.0 23.3 9.9 57.9 9.1 24.3 10.0 0.3 5.9 13.2 15.5 20.4 21.4 2.7 11.3 57.9 20.8 0.0 2.8 0.1 0.0 0.0 2.4 0.0 2.6 0.0 1.0 1.3 0.0 0.0 0.3 1.0 0.1 3.3 0.0 0.0 0.1 0.4 4.6 5.2 5.2 7.9 4.9 5.0 5.8 5.4 6.0 5.8 5.3 7.8 2.1 0.0 7.8 51.2 1.6 1.8 3.0 8.6 2.8 24.4 3.8 2.8 3.2 8.6 9.8 11.0 37.5 2.5 8.9 38.1 5.9 13.0 7.6 3.5 11.1 2.2 3.0 34.9 83.4 8.2 26.8 6.9 30.5 6.3 6.3 8.3 4.2 102.0 1.9 26.9 78.5 14.4 8.2 3.0 0.3 3.9 1.2 0.7 0.0 18.7 0.1 5.5 18.6 56.3 77.3 16.6 24.8 1.2 2.9 2.5 7.1 6.9 2.9 16.3 6.6 6.4 7.5 0.2 1.5 19.9 7.0 2.1 9.6 11.8 22.4 5.1 ELOVL7 FLJ23563 ENSG00000164181 "ELOVL fatty acid elongase 7" A1L3X0 5 60751791-60844274 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Microglial cells: 190.2;Oligodendrocytes: 90.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 5 "basophil: 1.9;neutrophil: 1.3" "Lineage enriched" "Detected in single" 17 "granulocytes: 1.9" "Cell line enhanced" "Detected in many" "GAMG: 41.9;HDLM-2: 29.3;HEL: 37.3" "Low region specificity" "Detected in all" HPA036337 Approved NA NA "Cluster 10: Basophils - Unknown function" "Cluster 27: Brain & Skin - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 44: Endometrium - Transcription" "HPA036337: AB_10670797" "unprognostic (6.34e-2)" "unprognostic (1.96e-2)" "unprognostic (1.51e-2)" "prognostic unfavorable (3.87e-5)" "unprognostic (3.84e-1)" "unprognostic (1.66e-1)" "unprognostic (1.60e-2)" "unprognostic (1.02e-1)" "unprognostic (1.76e-1)" "unprognostic (1.79e-1)" "unprognostic (2.37e-1)" "unprognostic (2.10e-1)" "prognostic favorable (1.54e-9)" "unprognostic (6.95e-2)" "unprognostic (1.01e-3)" "unprognostic (2.94e-1)" "unprognostic (6.30e-3)" 10.5 5.5 23.1 2.2 24.9 1.0 22.1 29.5 26.5 3.6 36.2 8.8 11.8 2.2 0.9 5.0 2.8 19.3 0.9 18.3 30.0 16.2 1.0 3.8 2.5 31.8 26.3 0.5 8.5 21.0 2.7 0.8 32.9 22.0 11.5 10.5 4.7 1.2 0.5 26.2 21.3 3.7 30.1 0.5 3.3 0.8 32.9 1.8 16.8 1.0 4.0 7.6 6.7 32.2 20.7 7.6 0.1 0.5 0.0 0.0 18.6 0.0 4.3 2.5 8.4 9.6 21.4 0.0 9.1 0.0 41.9 1.2 11.9 8.3 3.8 29.3 6.9 37.3 0.9 3.2 0.2 3.0 15.2 0.1 14.6 0.3 12.3 0.9 0.0 6.5 5.9 7.2 0.0 17.8 0.1 0.3 2.4 1.9 0.1 1.6 1.9 1.2 19.4 18.5 7.8 1.2 10.9 8.8 5.0 2.0 14.2 0.6 0.2 1.5 9.0 0.2 7.2 18.5 19.7 0.3 13.2 0.8 0.4 1.9 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 2.5 23.1 24.9 29.5 26.5 18.3 30.0 31.8 26.3 32.9 30.1 32.9 32.2 14.5 12.8 3.1 4.9 0.5 31.1 13.1 1.4 4.6 2.3 3.1 1.4 0.7 20.0 4.8 12.9 0.0 0.2 0.3 8.8 5.9 6.8 0.1 6.5 1.6 21.1 4.8 1.3 29.5 3.1 0.0 2.0 5.6 20.4 12.7 0.4 0.4 0.0 0.1 0.0 26.0 17.0 0.0 0.0 16.6 0.0 0.0 4.9 10.6 190.2 2.0 3.5 0.0 6.0 90.8 7.1 13.3 0.0 0.1 23.4 29.7 8.9 1.7 6.7 0.0 1.0 0.8 0.2 1.1 2.9 38.2 2.9 0.9 0.2 15.9 8.6 EOGT "AER61, C3orf64, FLJ33770" ENSG00000163378 "EGF domain specific O-linked N-acetylglucosamine transferase" Q5NDL2 3 68975217-69013684 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Peritubular cells: 40.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HUVEC TERT2: 86.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019460 Approved Approved "Nucleoplasm,Nuclear membrane,Cytosol" "Intracellular and membrane" NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 46: Fibroblasts - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Nuclear membrane" Cytosol "HPA019460: AB_1844628" "unprognostic (2.62e-1)" "unprognostic (3.72e-1)" "unprognostic (1.07e-1)" "unprognostic (1.95e-2)" "unprognostic (8.96e-2)" "unprognostic (6.30e-2)" "unprognostic (2.18e-3)" "unprognostic (6.66e-2)" "unprognostic (1.13e-2)" "unprognostic (2.57e-1)" "unprognostic (1.68e-1)" "unprognostic (3.57e-1)" "prognostic unfavorable (8.97e-5)" "unprognostic (7.41e-2)" "unprognostic (4.67e-1)" "unprognostic (3.44e-2)" "unprognostic (2.04e-1)" 19.4 9.1 7.2 12.8 7.2 5.9 19.5 6.7 10.9 14.0 22.4 25.8 7.4 29.9 9.8 17.5 18.5 17.8 28.5 7.1 7.0 10.2 5.7 28.7 8.2 7.7 7.6 11.6 12.6 5.0 9.3 22.3 8.0 27.9 8.6 8.8 16.4 33.7 20.0 9.7 11.4 25.4 7.8 10.0 15.5 8.9 7.8 11.1 7.9 15.2 8.8 24.7 13.7 7.5 19.0 7.1 12.5 14.4 16.6 32.2 8.6 25.4 31.5 16.0 21.0 9.1 10.2 1.1 3.8 28.1 13.6 6.0 8.3 32.3 19.9 62.3 5.6 20.2 15.5 13.5 18.7 11.5 8.2 26.8 29.4 20.6 25.1 19.4 86.2 0.8 5.9 11.1 53.7 5.5 2.0 3.8 13.5 6.2 3.5 0.8 12.4 8.2 13.9 43.4 1.2 6.3 29.1 1.7 23.5 12.8 6.0 15.9 44.6 40.6 13.4 5.1 24.3 6.0 20.5 9.3 16.3 17.1 23.8 5.4 1.5 0.0 2.0 1.4 2.3 1.1 3.0 4.3 2.4 0.7 2.5 2.7 0.2 2.4 0.5 0.4 6.6 1.3 7.2 7.2 6.7 10.9 7.1 7.0 7.7 7.6 8.0 7.8 7.8 7.5 29.6 12.8 10.3 14.0 3.5 7.1 11.4 13.2 16.5 2.2 7.5 11.7 20.7 4.3 14.5 1.8 16.7 0.9 3.1 5.1 0.0 4.6 16.5 15.3 7.5 23.7 6.0 3.8 11.2 8.2 5.3 9.3 9.2 15.4 0.0 9.4 20.3 3.6 6.7 0.0 21.4 4.5 2.0 6.8 9.8 15.1 3.1 8.6 8.8 30.9 6.5 1.4 1.0 9.5 12.2 12.4 3.4 40.6 5.4 8.3 2.1 1.9 13.2 5.6 0.0 26.8 15.2 5.5 2.5 14.8 4.5 0.8 7.0 6.9 3.4 8.6 EP300 "KAT3B, p300" ENSG00000100393 "E1A binding protein p300" Q09472 22 41092592-41180077 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Biological rhythms, Cell cycle, Host-virus interaction, Transcription, Transcription regulation" "Acyltransferase, Transferase" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000146, HPA003128, HPA004112" Supported Enhanced Nucleoplasm NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 44: Endometrium - Transcription" Nucleoplasm "CAB000146: AB_2533138, HPA003128: AB_1078745, HPA004112: AB_1078746" "unprognostic (7.67e-2)" "unprognostic (5.56e-2)" "unprognostic (2.29e-1)" "unprognostic (2.52e-1)" "unprognostic (6.10e-3)" "unprognostic (1.66e-1)" "unprognostic (2.21e-2)" "unprognostic (2.13e-1)" "unprognostic (1.54e-1)" "unprognostic (8.97e-2)" "unprognostic (1.74e-2)" "unprognostic (8.54e-2)" "prognostic favorable (7.45e-5)" "unprognostic (7.97e-2)" "unprognostic (1.41e-1)" "unprognostic (1.01e-1)" "unprognostic (8.66e-2)" 15.7 13.7 6.8 17.7 8.9 65.1 14.2 20.5 10.8 16.0 6.1 16.6 13.6 17.2 13.5 16.3 16.4 14.2 11.5 7.1 9.4 13.1 15.5 14.7 17.6 10.6 7.8 23.9 18.0 23.2 13.4 19.3 7.7 15.0 14.5 17.8 15.0 15.6 20.4 18.9 16.0 16.4 5.3 17.0 14.5 19.6 8.6 27.2 20.2 23.4 17.9 15.4 14.8 11.2 31.6 21.7 35.4 23.0 22.2 23.3 32.3 15.0 21.8 21.0 21.0 27.8 12.0 32.7 12.2 28.4 18.7 24.1 48.1 20.8 23.5 30.5 32.2 24.4 25.4 22.3 26.9 59.3 26.5 24.8 22.2 30.0 27.0 19.3 24.9 18.7 26.3 43.9 18.3 12.5 16.2 18.9 27.5 38.3 15.2 33.7 16.7 21.3 20.3 40.4 11.3 11.9 51.1 26.0 25.6 29.5 17.8 33.9 31.3 20.3 24.8 16.3 20.8 28.5 14.1 47.9 16.3 17.4 21.5 3.6 1.7 1.6 1.6 1.9 1.5 2.2 1.7 1.7 2.1 1.4 1.4 1.1 4.9 2.7 1.0 1.6 1.4 1.2 6.8 8.9 20.5 10.8 7.1 9.4 10.6 7.8 7.7 5.3 8.6 11.2 45.4 67.3 49.2 58.1 53.8 24.6 22.9 11.6 40.9 44.6 35.1 25.8 31.6 38.6 15.8 25.8 35.5 18.4 63.2 37.0 3.9 16.1 15.3 55.1 56.4 36.2 24.7 60.4 71.8 18.7 17.9 32.0 27.5 72.5 25.3 36.1 32.9 29.2 18.4 25.2 73.6 24.2 2.0 60.7 25.7 6.4 28.9 60.5 8.8 45.9 52.0 27.7 40.2 81.4 80.3 25.8 28.9 30.5 51.2 30.8 20.2 10.8 22.8 30.9 26.3 47.6 36.7 22.8 31.2 35.3 25.9 30.2 46.0 36.7 23.7 36.3 EPHA1 "EPH, EPHT, EPHT1" ENSG00000146904 "EPH receptor A1" P21709 7 143390289-143408856 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Angiogenesis, Cell adhesion" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "esophagus: 57.2;parathyroid gland: 206.5" "Cell type enhanced" "Detected in many" "Early spermatids: 23.3;Gastric mucus-secreting cells: 13.3;Proximal enterocytes: 13.2;Squamous epithelial cells: 28.7" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Group enriched" "Detected in some" 6 "memory CD4 T-cell: 1.9;naive CD4 T-cell: 3.8;naive CD8 T-cell: 2.9" "Lineage enriched" "Detected in single" 8 "T-cells: 3.8" "Cell line enhanced" "Detected in some" "CACO-2: 17.9;HaCaT: 16.6;HBEC3-KT: 13.5;MCF7: 15.0;NTERA-2: 54.4" "Low region specificity" "Detected in single" "Low region specificity" "Detected in single" CAB026144 Uncertain NA NA 32000000 "Cluster 32: T-cells - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 5: NTERA-2 - Transcription" "Cluster 61: Squamous epithelial cells - Keratinization" "CAB026144: " "unprognostic (1.54e-2)" "unprognostic (3.04e-2)" "unprognostic (2.07e-1)" "unprognostic (4.58e-3)" "unprognostic (5.82e-3)" "unprognostic (2.45e-2)" "unprognostic (9.56e-2)" "unprognostic (1.81e-2)" "unprognostic (5.09e-1)" "unprognostic (7.59e-3)" "unprognostic (6.54e-2)" "unprognostic (3.24e-3)" "prognostic favorable (1.14e-6)" "unprognostic (3.73e-2)" "unprognostic (3.28e-2)" "unprognostic (1.91e-1)" "unprognostic (1.21e-1)" 0.1 0.0 0.0 1.3 0.0 0.3 2.2 0.4 0.1 11.2 1.2 3.7 8.4 0.3 1.2 57.2 3.4 1.5 0.0 0.0 0.0 5.8 15.6 2.3 2.0 0.0 0.0 0.0 5.7 206.5 2.5 0.6 0.0 4.0 1.6 0.0 11.0 1.2 0.0 19.7 6.2 0.1 0.0 0.9 4.2 1.9 0.0 3.4 5.4 0.0 3.5 1.9 25.8 0.1 8.7 0.0 0.0 0.0 0.0 0.0 7.9 0.0 0.0 0.0 0.0 17.9 7.1 0.0 0.1 0.0 0.0 16.6 0.0 13.5 0.0 0.0 0.0 1.8 0.0 1.7 0.0 0.8 0.1 0.0 4.4 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.0 15.0 0.0 1.9 54.4 8.8 0.0 0.0 0.0 0.0 1.1 6.7 0.3 0.0 0.0 8.2 0.0 3.2 3.8 0.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 3.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.5 0.2 0.0 3.8 2.9 0.1 0.1 0.0 0.4 0.1 1.0 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 2.2 0.3 0.1 2.0 6.3 6.5 6.8 0.0 3.3 5.0 1.0 2.8 9.9 7.3 0.0 2.0 0.2 4.2 0.0 4.4 23.3 4.0 1.0 0.2 1.2 0.0 0.6 4.3 2.6 0.5 13.3 6.6 0.0 0.0 0.4 8.8 0.4 0.0 0.3 4.7 2.0 0.3 0.3 9.9 0.6 0.3 0.0 1.0 0.0 0.3 0.0 0.5 0.2 6.3 8.8 0.0 0.6 2.0 13.2 1.5 2.1 0.2 0.0 0.4 0.4 0.5 1.9 28.7 3.7 1.0 4.4 0.0 7.6 5.5 EPHA10 "FLJ16103, FLJ33655" ENSG00000183317 "EPH receptor A10" Q5JZY3 1 37713880-37765133 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 7.6;intestine: 13.4;testis: 13.4" "Group enriched" "Detected in some" 4 "Cone photoreceptor cells: 91.8;Early spermatids: 59.1;Late spermatids: 183.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 4.9;HDLM-2: 19.4;SCLC-21H: 8.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA027497 Uncertain "Intracellular and membrane" NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 44: HDLM-2 - Immune response" "Cluster 25: Spermatids - Spermatogenesis" "HPA027497: AB_10601158" "unprognostic (9.27e-2)" "unprognostic (1.21e-1)" "unprognostic (2.94e-2)" "unprognostic (1.24e-6)" "unprognostic (1.06e-1)" "unprognostic (1.11e-2)" "unprognostic (5.39e-2)" "unprognostic (1.25e-1)" "unprognostic (2.55e-2)" "unprognostic (1.40e-1)" "unprognostic (7.06e-3)" "unprognostic (1.50e-1)" "unprognostic (8.81e-5)" "unprognostic (2.55e-2)" "unprognostic (2.97e-2)" "unprognostic (2.67e-1)" "unprognostic (3.04e-2)" 0.0 0.4 4.2 0.9 4.4 0.3 0.9 0.0 7.6 0.2 0.0 13.4 3.5 0.1 3.9 0.4 0.9 1.0 0.1 4.3 2.1 0.2 0.0 0.1 0.2 1.9 0.4 0.0 2.6 1.3 6.7 0.0 0.7 0.6 6.3 3.1 1.4 0.2 0.0 0.2 6.7 0.4 0.0 0.1 3.1 13.4 4.1 0.1 0.4 0.0 0.1 0.2 0.2 1.8 1.5 1.0 0.0 0.0 0.0 0.0 4.9 0.0 0.0 0.0 0.0 1.6 2.7 0.0 0.4 0.0 0.2 0.1 0.1 0.0 0.0 19.4 0.7 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.7 0.0 1.0 0.0 0.1 0.7 2.0 0.6 0.0 0.0 0.4 0.3 1.7 8.6 0.4 1.1 0.0 0.0 0.2 2.8 0.1 0.0 0.0 0.9 0.1 0.0 1.7 1.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 4.2 4.4 0.0 7.6 4.3 2.1 1.9 0.4 0.7 0.0 4.1 1.8 0.0 0.0 0.5 0.3 0.2 0.1 0.0 0.0 0.0 5.6 1.3 0.9 1.5 0.0 0.1 0.0 91.8 0.0 0.0 23.8 0.0 0.4 59.1 0.0 0.0 0.1 18.7 0.0 24.5 2.5 0.0 0.3 1.5 0.1 0.0 0.1 0.0 0.0 0.0 11.8 15.8 10.5 0.0 0.0 0.0 183.7 1.8 0.1 0.0 1.0 0.0 0.4 0.0 2.5 2.2 2.3 21.1 0.4 0.0 0.2 7.8 0.0 0.0 3.1 0.0 0.0 0.1 18.2 2.6 0.0 0.0 0.0 0.1 0.0 11.0 0.2 EPHA2 ECK ENSG00000142627 "EPH receptor A2" P29317 1 16124337-16156069 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins, RAS pathway related proteins" "Angiogenesis, Apoptosis, Cell adhesion, Differentiation, Host-virus interaction" "Host cell receptor for virus entry, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Cataract, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 147.9" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 202.3;Glandular and luminal cells: 182.9;Squamous epithelial cells: 156.3;Suprabasal keratinocytes: 248.3;Urothelial cells: 200.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 94 "plasmacytoid DC: 9.4" "Lineage enriched" "Detected in single" 94 "dendritic cells: 9.4" "Cell line enhanced" "Detected in many" "CAPAN-2: 201.1;PC-3: 229.0;U-251 MG: 242.1;WM-115: 258.2" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" CAB010464 Supported "Nuclear speckles,Golgi apparatus,Plasma membrane,Cell Junctions" NA Yes 12000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 44: Endometrium - Transcription" "Plasma membrane, Cell Junctions" "Nuclear speckles, Golgi apparatus" "CAB010464: AB_631436" "unprognostic (9.41e-2)" "unprognostic (1.67e-1)" "unprognostic (4.13e-2)" "unprognostic (1.67e-2)" "unprognostic (6.22e-2)" "unprognostic (9.12e-2)" "unprognostic (5.24e-2)" "unprognostic (1.29e-3)" "unprognostic (2.52e-2)" "unprognostic (7.05e-3)" "unprognostic (1.52e-3)" "unprognostic (2.77e-1)" "unprognostic (2.65e-2)" "unprognostic (2.08e-1)" "unprognostic (1.73e-1)" "unprognostic (4.77e-3)" "unprognostic (4.40e-2)" 21.4 9.5 3.5 4.8 3.1 0.3 14.6 2.9 3.7 38.2 11.7 12.4 10.0 12.1 1.3 147.9 13.5 28.2 15.8 3.1 3.1 18.7 18.9 17.9 7.6 3.8 3.7 5.8 23.2 3.7 7.4 14.0 3.8 11.2 5.8 6.4 67.7 4.2 4.6 40.3 12.8 3.7 3.6 7.6 15.6 1.8 4.3 3.2 15.2 5.1 11.1 56.1 58.8 3.1 76.9 151.7 41.4 20.1 2.9 3.5 24.3 45.2 63.4 79.9 50.6 63.9 201.1 0.1 189.8 25.9 98.8 30.6 9.9 104.4 27.6 0.4 7.0 0.0 46.7 41.1 51.3 0.1 0.2 4.8 38.1 43.7 95.6 125.0 86.4 0.0 0.3 0.1 51.6 24.3 0.0 0.0 20.0 57.2 229.0 0.1 37.6 0.2 85.1 39.0 0.1 6.4 87.8 21.2 6.1 21.3 3.0 0.9 108.1 28.5 76.7 2.0 242.1 0.0 0.5 0.6 22.0 0.1 258.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.4 0.0 0.0 3.5 3.1 2.9 3.7 3.1 3.1 3.8 3.7 3.8 3.6 4.3 3.1 17.1 54.5 38.4 2.0 1.2 202.3 114.3 110.9 66.0 2.7 39.5 43.9 6.5 44.3 113.4 9.2 4.2 9.7 8.9 96.8 0.0 33.8 5.8 104.5 19.2 26.3 3.0 0.0 0.1 14.2 1.2 5.8 68.3 182.9 5.7 0.4 29.3 23.3 1.9 0.0 0.2 42.0 34.6 1.6 17.0 0.2 3.4 3.7 26.6 4.7 1.1 7.1 0.0 0.0 0.0 104.6 111.7 0.0 0.0 60.8 22.4 1.8 89.8 2.5 32.9 11.6 21.2 0.2 0.8 156.3 248.3 7.5 2.6 0.4 42.9 200.4 EPHA3 "ETK, ETK1, HEK, HEK4, TYRO4" ENSG00000044524 "EPH receptor A3" P29320 3 89107621-89482134 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "prostate: 31.5" "Group enriched" "Detected in some" 4 "Excitatory neurons: 70.6;Inhibitory neurons: 106.6;Microglial cells: 103.0;Oligodendrocytes: 48.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 5 "AF22: 197.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "CAB010462, HPA069390" Approved Supported "Nucleoplasm,Nuclear membrane,Plasma membrane,Actin filaments,Cytosol" "Intracellular and membrane" NA NA "Cluster 46: Fibroblasts - ECM organization" "Cluster 12: NES - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nuclear membrane, Plasma membrane, Cytosol" "Nucleoplasm, Actin filaments" "CAB010462: AB_2099218, HPA069390: " "unprognostic (1.48e-3)" "unprognostic (2.30e-2)" "unprognostic (4.95e-2)" "unprognostic (1.90e-1)" "unprognostic (2.96e-2)" "unprognostic (1.47e-2)" "unprognostic (2.03e-1)" "unprognostic (9.10e-3)" "unprognostic (1.24e-3)" "unprognostic (7.43e-2)" "unprognostic (1.83e-1)" "unprognostic (2.23e-1)" "prognostic unfavorable (3.28e-7)" "unprognostic (3.63e-2)" "unprognostic (1.88e-2)" "unprognostic (4.05e-2)" "unprognostic (1.20e-2)" 5.4 1.0 2.1 1.8 1.3 0.0 2.3 0.2 3.8 12.3 0.1 3.8 2.3 5.5 0.2 3.2 1.3 18.8 8.2 2.2 0.7 1.3 4.9 2.4 3.6 3.3 0.9 4.1 2.1 1.0 0.9 20.1 4.0 31.5 6.2 8.0 2.2 7.1 0.8 0.7 2.4 7.9 0.8 0.9 2.5 1.0 1.7 1.0 11.0 6.3 3.2 14.3 6.4 2.2 0.0 0.0 197.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.6 0.0 0.0 0.0 11.2 0.2 0.7 0.0 2.4 0.0 0.0 11.8 0.0 0.0 1.7 2.0 0.0 3.9 0.0 0.0 0.6 0.0 2.5 0.1 0.3 0.0 2.6 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.1 0.0 0.1 0.0 0.5 0.1 0.1 36.1 0.1 0.0 0.0 1.7 0.0 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 1.3 0.2 3.8 2.2 0.7 3.3 0.9 4.0 0.8 1.7 2.2 2.2 0.0 0.0 5.5 0.0 0.5 0.3 0.0 0.6 6.4 0.0 0.1 2.4 0.0 0.0 0.0 2.1 0.2 0.0 0.0 0.0 0.0 1.8 0.0 0.5 1.8 0.0 0.0 70.6 0.0 0.1 18.1 0.5 0.0 0.0 0.0 1.1 0.0 0.1 20.2 106.6 0.0 0.0 0.0 0.7 1.6 2.1 0.1 0.0 103.0 0.0 4.7 0.0 2.5 48.0 0.0 0.0 8.2 0.0 0.1 0.0 0.0 0.0 18.7 6.6 0.7 19.2 0.1 0.0 0.3 0.3 0.5 0.2 1.3 0.0 0.1 EPHA4 "Hek8, TYRO1" ENSG00000116106 "EPH receptor A4" P54764 2 221418027-221574202 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion, Neurogenesis" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 39.7" "Cell type enriched" "Detected in many" 4 "Excitatory neurons: 317.9" "Cancer enhanced" "Detected in many" "thyroid cancer: 14.9" "Group enriched" "Detected in many" 6 "cerebral cortex: 23.8;hippocampal formation: 20.9" "Group enriched" "Detected in many" 9 "basophil: 1.6;gdT-cell: 1.7;MAIT T-cell: 1.7;memory B-cell: 1.3;memory CD4 T-cell: 2.5;memory CD8 T-cell: 1.7;naive B-cell: 1.2;naive CD4 T-cell: 1.0;NK-cell: 3.5;T-reg: 1.2" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "AF22: 77.0;ASC diff: 33.9;CACO-2: 59.3;U-2197: 38.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB028368 Enhanced NA NA 9300000 "Cluster 22: NK-cells - Unknown function" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "CAB028368: AB_2099353" "unprognostic (1.28e-1)" "unprognostic (5.87e-2)" "unprognostic (2.28e-1)" "unprognostic (2.46e-2)" "unprognostic (5.99e-2)" "unprognostic (1.33e-1)" "unprognostic (7.05e-4)" "unprognostic (1.80e-2)" "unprognostic (2.40e-1)" "prognostic unfavorable (9.56e-4)" "unprognostic (1.12e-1)" "unprognostic (2.85e-2)" "prognostic favorable (5.67e-4)" "unprognostic (3.12e-2)" "unprognostic (1.96e-1)" "unprognostic (2.36e-1)" "unprognostic (8.66e-2)" 7.8 1.6 0.0 1.9 3.9 3.7 3.9 0.0 23.8 4.5 39.7 4.6 1.0 6.4 2.8 4.8 4.9 3.1 17.4 20.9 0.0 4.8 0.8 3.6 2.7 0.0 1.5 11.1 1.1 1.9 0.6 1.6 0.0 5.3 4.5 4.2 2.6 6.1 2.7 12.9 2.8 8.0 0.0 3.4 2.3 11.7 3.7 3.8 9.5 4.0 3.2 3.6 3.5 0.0 2.6 2.4 77.0 0.0 33.9 20.9 0.1 18.2 8.3 16.9 6.2 59.3 0.9 0.0 0.1 26.7 0.0 7.0 12.3 0.1 7.0 9.7 6.4 0.0 0.9 0.0 0.9 0.0 1.4 8.5 4.2 5.3 0.1 10.3 14.9 0.0 0.0 0.0 4.4 9.5 0.2 0.0 5.6 5.9 1.7 0.1 8.5 0.0 25.8 4.3 13.2 0.0 6.2 1.3 1.3 6.2 2.9 0.0 0.0 1.7 3.2 38.4 1.0 0.0 0.1 0.0 6.9 0.0 3.6 1.6 0.0 0.0 1.7 0.0 1.7 1.3 2.5 1.7 0.0 1.2 1.0 0.2 0.1 3.5 0.0 0.1 1.2 0.4 0.0 3.9 0.0 23.8 20.9 0.0 0.0 1.5 0.0 0.0 3.7 0.0 36.3 0.0 6.4 51.9 8.2 6.1 0.7 9.7 2.8 9.8 4.3 6.0 31.6 7.2 13.7 9.2 0.0 0.1 12.2 4.7 7.9 0.2 3.9 1.9 5.7 26.3 3.5 0.0 317.9 0.2 0.0 5.1 4.6 5.2 1.3 9.0 20.0 0.4 0.3 1.7 68.8 12.8 8.2 0.0 1.5 5.8 1.2 0.9 7.2 70.3 0.2 7.2 3.1 8.0 7.9 30.9 3.6 8.6 2.1 1.4 0.1 1.7 4.5 3.2 0.0 3.6 10.2 10.0 1.9 4.1 12.5 0.0 5.4 11.3 6.6 2.4 EPHA5 "CEK7, EHK1, Hek7, TYRO4" ENSG00000145242 "EPH receptor A5" P54756 4 65319563-65670495 "Enzymes, Metabolic proteins, Predicted membrane proteins" Neurogenesis "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 9 "brain: 21.3" "Group enriched" "Detected in some" 10 "Excitatory neurons: 202.5;Inhibitory neurons: 162.8;Oligodendrocyte precursor cells: 96.0" "Cancer enhanced" "Detected in some" "glioma: 0.8;prostate cancer: 0.5" "Region enhanced" "Detected in many" "cerebral cortex: 21.3" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "hTERT-RPE1: 10.0;PC-3: 9.4;TIME: 12.6;U-138 MG: 25.5;U-2197: 15.7;U-251 MG: 20.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA 33000 "Cluster 10: Brain - Neuronal signaling" "Cluster 18: U-2197 - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "unprognostic (1.02e-2)" "unprognostic (4.22e-2)" "unprognostic (2.38e-1)" "unprognostic (4.89e-4)" "unprognostic (7.43e-4)" "unprognostic (1.60e-1)" "unprognostic (6.68e-3)" "unprognostic (2.49e-1)" "unprognostic (1.12e-1)" "unprognostic (1.03e-2)" "unprognostic (9.25e-2)" "unprognostic (5.88e-3)" "unprognostic (2.55e-2)" "unprognostic (5.97e-4)" "unprognostic (3.81e-3)" 0.0 0.8 3.3 0.1 5.3 0.0 0.0 0.0 21.3 2.0 0.0 0.1 0.0 0.4 0.0 0.1 0.0 0.0 0.8 16.2 2.4 0.0 0.0 0.1 0.0 2.6 1.4 2.3 0.0 0.0 0.7 0.9 4.0 1.5 0.1 1.5 0.3 1.4 0.0 0.2 0.0 0.2 1.8 0.3 0.3 0.7 0.3 0.0 0.9 0.0 0.0 0.1 0.5 3.1 0.0 0.7 0.8 0.0 0.8 0.4 0.0 0.4 1.3 0.7 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.3 0.0 4.4 0.0 4.9 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 10.0 0.3 0.0 0.0 1.5 2.6 0.0 0.0 0.0 0.1 0.0 9.4 0.0 2.9 0.5 0.0 0.0 1.1 0.0 0.0 0.0 4.3 0.0 0.0 0.0 12.6 25.5 3.1 15.7 20.6 0.0 0.0 0.0 2.6 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 5.3 0.0 21.3 16.2 2.4 2.6 1.4 4.0 1.8 0.3 3.1 0.0 0.0 0.0 8.5 0.0 0.5 0.0 0.0 0.0 2.7 0.0 0.1 4.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.4 0.0 2.2 0.1 0.0 0.0 202.5 0.0 0.0 0.7 0.0 0.0 0.0 0.8 0.0 0.0 0.1 1.7 162.8 0.0 0.0 0.0 0.0 15.2 0.9 0.0 3.6 5.6 0.0 5.7 0.0 96.0 4.8 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 1.4 0.0 0.0 0.4 0.7 0.4 0.0 0.1 0.0 0.0 0.7 0.0 0.1 EPHA6 FLJ35246 ENSG00000080224 "EPH receptor A6" Q9UF33 3 96814581-97752460 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "brain: 24.2;ovary: 6.3;testis: 8.4" "Cell type enhanced" "Detected in some" "Astrocytes: 421.5;Early spermatids: 401.8;Excitatory neurons: 423.8;Inhibitory neurons: 879.2;Late spermatids: 208.7" "Cancer enhanced" "Detected in single" "prostate cancer: 0.7" "Region enhanced" "Detected in many" "cerebellum: 24.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 6 "HEK 293: 9.3;U-266/70: 28.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007397, HPA058047" Uncertain Enhanced Nucleoplasm NA NA "Cluster 6: Brain - Smell perception" "Cluster 29: U-266 - Adaptive immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "HPA007397: AB_2667821, HPA058047: AB_2683588" "unprognostic (9.87e-2)" "unprognostic (1.67e-2)" "unprognostic (3.42e-4)" "unprognostic (7.21e-5)" "unprognostic (8.51e-2)" "unprognostic (1.32e-1)" "unprognostic (1.82e-2)" "unprognostic (3.14e-1)" "unprognostic (1.87e-1)" "unprognostic (1.34e-1)" "unprognostic (2.22e-1)" "unprognostic (1.71e-4)" "unprognostic (1.93e-3)" "unprognostic (1.76e-1)" "unprognostic (1.48e-2)" "unprognostic (7.14e-3)" 0.2 0.0 6.5 0.0 12.7 0.0 0.2 24.2 10.9 0.8 0.0 3.2 0.1 0.9 0.3 0.8 1.9 0.9 0.3 11.4 0.0 0.4 0.0 0.1 0.0 0.0 0.2 6.3 0.5 0.1 0.1 0.0 1.1 1.0 0.7 1.1 0.1 0.6 0.0 0.0 0.3 1.4 0.1 0.0 0.6 8.4 3.5 0.2 2.0 0.1 0.1 1.4 0.6 0.0 0.0 0.3 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 9.3 0.0 2.2 0.0 0.0 2.3 0.0 0.0 0.4 0.0 0.9 0.9 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.8 1.0 0.0 0.0 0.0 0.0 0.5 0.0 0.1 0.0 2.4 0.0 0.9 28.1 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.5 12.7 24.2 10.9 11.4 0.0 0.0 0.2 1.1 0.1 3.5 0.0 0.0 0.0 0.0 421.5 0.1 0.3 0.3 0.0 5.2 1.6 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 401.8 0.1 1.4 0.1 0.0 0.0 423.8 0.0 0.0 0.9 0.0 0.1 0.0 0.3 0.0 0.0 0.1 0.0 879.2 0.0 0.0 0.0 0.0 208.7 3.1 0.2 0.0 30.0 0.0 1.0 0.0 31.2 9.0 0.1 0.0 1.5 0.0 0.1 0.0 1.7 0.0 0.3 0.0 0.2 0.1 14.7 2.7 6.0 0.0 0.1 0.0 0.4 0.0 0.1 EPHA7 Hek11 ENSG00000135333 "EPH receptor A7" Q15375 6 93240020-93419687 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Neurogenesis" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "intestine: 24.6;parathyroid gland: 69.9" "Group enriched" "Detected in some" 8 "Excitatory neurons: 138.6;Inhibitory neurons: 172.0" "Cancer enhanced" "Detected in many" "renal cancer: 6.4" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "AF22: 12.0;HEK 293: 35.1;RH-30: 31.7;THP-1: 32.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB010496 Approved "Intracellular and membrane" NA NA 660000 "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 43: THP-1 - Innate immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB010496: AB_2099673" "unprognostic (3.34e-1)" "unprognostic (7.82e-2)" "unprognostic (1.41e-1)" "unprognostic (9.32e-2)" "unprognostic (1.19e-1)" "unprognostic (3.56e-2)" "unprognostic (1.62e-2)" "unprognostic (4.07e-1)" "unprognostic (4.16e-2)" "unprognostic (3.19e-2)" "unprognostic (5.69e-2)" "unprognostic (1.69e-1)" "unprognostic (1.74e-2)" "unprognostic (1.35e-1)" "unprognostic (1.56e-2)" "unprognostic (4.82e-2)" 0.3 0.0 1.2 0.4 3.4 0.0 1.2 3.4 5.1 1.4 0.0 24.6 1.5 0.9 0.2 0.2 0.5 2.2 3.6 4.9 2.6 5.9 0.0 0.2 0.0 1.2 2.2 1.9 0.1 69.9 1.2 0.4 1.5 9.7 2.5 1.8 5.4 0.9 0.1 0.2 4.4 2.1 0.4 3.9 10.3 0.9 0.6 0.0 0.1 0.1 0.0 8.2 1.8 1.2 0.0 0.5 12.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 35.1 0.0 3.0 0.0 0.0 0.0 0.0 0.5 0.0 5.0 0.0 0.0 0.0 0.0 0.0 0.0 5.8 0.0 0.0 0.0 0.6 0.0 1.0 5.4 31.7 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.1 0.0 32.6 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 3.4 3.4 5.1 4.9 2.6 1.2 2.2 1.5 0.4 0.6 1.2 0.2 0.0 0.0 4.2 0.0 0.4 0.4 0.0 0.6 18.5 3.1 1.8 17.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 13.1 1.3 1.4 1.8 0.0 0.0 138.6 0.0 0.0 5.9 0.0 3.8 0.0 3.7 0.0 0.0 0.1 11.8 172.0 0.0 0.0 0.0 0.4 3.3 0.9 0.1 0.0 11.2 0.0 0.4 0.0 4.5 8.3 0.1 0.0 0.0 0.0 0.4 0.0 11.8 0.0 1.0 0.0 0.2 0.5 0.2 1.1 0.2 1.0 0.0 0.2 0.9 0.0 0.1 EPHA8 "EEK, Hek3" ENSG00000070886 "EPH receptor A8" P29322 1 22563489-22603595 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion, Neurogenesis" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "choroid plexus: 27.8" "Cell type enhanced" "Detected in some" "Bipolar cells: 4.2;Cone photoreceptor cells: 2.1;Early spermatids: 2.8;Horizontal cells: 3.3;Late spermatids: 5.8;Rod photoreceptor cells: 8.8" "Cancer enhanced" "Detected in single" "testis cancer: 0.5" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 12 "SCLC-21H: 59.6" "Region enhanced" "Detected in many" "cerebellum: 13.0" "Region enriched" "Detected in many" 4 "cerebellum: 11.7" "CAB009660, HPA031433" Uncertain "Intracellular and membrane" NA NA "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 46: Photoreceptor cells - Phototransduction" "CAB009660: AB_2099696, HPA031433: AB_10601371" "unprognostic (8.58e-2)" "unprognostic (8.59e-2)" "unprognostic (3.72e-1)" "unprognostic (1.15e-2)" "unprognostic (4.69e-4)" "unprognostic (3.58e-1)" "unprognostic (7.14e-2)" "unprognostic (1.52e-1)" "unprognostic (4.75e-2)" "unprognostic (9.80e-2)" "unprognostic (2.10e-1)" "unprognostic (9.84e-14)" "unprognostic (2.14e-3)" "unprognostic (1.69e-1)" "unprognostic (2.76e-1)" "unprognostic (8.68e-2)" 0.0 3.5 2.7 0.0 2.3 0.0 0.0 1.5 2.3 0.0 27.8 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 4.9 5.3 0.0 0.0 0.0 0.0 1.9 3.1 0.0 3.3 0.0 1.5 0.0 2.0 0.0 0.0 2.2 0.0 0.0 0.0 0.1 0.0 0.0 2.3 4.6 0.0 2.2 4.1 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 59.6 4.8 0.0 0.1 0.0 0.0 1.5 0.0 0.0 0.0 0.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 2.3 1.5 2.3 4.9 5.3 1.9 3.1 2.0 2.3 4.1 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.2 0.1 0.0 1.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.1 0.0 0.0 0.6 0.2 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 3.3 1.3 0.0 0.0 0.0 0.0 5.8 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.1 0.1 0.0 0.4 0.0 0.1 0.0 0.0 0.0 8.8 0.0 0.0 0.1 1.1 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 EPHB1 "EPHT2, Hek6" ENSG00000154928 "EPH receptor B1" P54762 3 134597801-135260467 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion, Neurogenesis" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 40.6" "Cell type enhanced" "Detected in many" "Astrocytes: 198.8;dendritic cells: 53.7;Early spermatids: 42.2;Excitatory neurons: 47.9;Inhibitory neurons: 44.3;Late spermatids: 41.2;Oligodendrocyte precursor cells: 77.9" "Cancer enriched" "Detected in many" 6 "glioma: 7.0" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 33 "neutrophil: 24.0;plasmacytoid DC: 23.3" "Group enriched" "Detected in many" 33 "dendritic cells: 23.3;granulocytes: 24.0" "Group enriched" "Detected in some" 5 "HDLM-2: 63.9;HMC-1: 35.5;RPTEC TERT1: 16.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA067740 Enhanced Approved "Endoplasmic reticulum,Plasma membrane,Cytosol" NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 44: HDLM-2 - Immune response" "Cluster 64: Astrocytes - Nervous system maintenance" "Endoplasmic reticulum, Plasma membrane, Cytosol" "HPA067740: AB_2685895" "unprognostic (1.99e-1)" "unprognostic (3.45e-1)" "unprognostic (2.52e-1)" "unprognostic (1.41e-6)" "unprognostic (6.52e-2)" "unprognostic (1.31e-1)" "unprognostic (1.07e-1)" "unprognostic (8.15e-2)" "unprognostic (9.88e-2)" "unprognostic (1.55e-1)" "unprognostic (1.11e-1)" "unprognostic (1.75e-1)" "unprognostic (1.04e-1)" "unprognostic (4.82e-2)" "unprognostic (1.78e-1)" "unprognostic (1.37e-3)" "unprognostic (4.88e-4)" 1.0 0.6 4.7 0.8 18.7 0.7 3.2 40.6 12.8 1.8 0.0 3.2 1.4 2.2 0.9 1.9 1.3 1.7 0.3 7.0 5.1 1.3 1.6 0.3 1.9 5.0 14.4 0.7 0.3 0.2 1.0 0.2 5.5 1.7 0.5 4.2 2.2 2.7 4.9 4.8 0.7 0.7 0.9 1.9 0.6 10.8 12.0 0.7 7.0 10.3 1.7 1.5 1.0 4.2 0.0 0.0 8.4 0.1 0.2 0.0 0.0 6.6 0.1 0.3 0.1 0.1 0.0 1.1 1.6 3.4 0.6 0.1 5.5 0.0 1.2 63.9 0.8 4.8 0.0 0.0 0.0 0.0 35.5 0.1 0.0 0.1 0.0 0.3 0.2 0.5 0.0 0.3 4.7 0.2 0.0 0.3 2.4 1.2 0.1 0.0 0.9 0.2 16.5 0.0 1.1 0.2 0.0 0.1 0.0 1.1 0.1 0.7 0.5 1.1 3.4 0.7 7.9 0.1 0.0 0.2 0.3 0.0 0.1 0.1 0.0 0.4 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 24.0 0.0 0.0 23.3 0.0 0.2 4.7 18.7 40.6 12.8 7.0 5.1 5.0 14.4 5.5 0.9 12.0 4.2 1.9 0.0 0.0 198.8 1.0 3.7 0.0 0.0 0.0 1.9 0.8 12.3 1.6 0.0 0.0 0.0 10.4 0.0 53.7 0.0 0.0 0.8 42.2 0.1 0.5 2.8 0.0 0.0 47.9 0.4 0.1 0.4 0.0 0.1 0.0 3.3 0.4 7.0 0.4 0.0 44.3 0.0 0.0 0.0 0.8 41.2 0.6 0.8 1.8 8.4 0.1 16.9 0.0 77.9 5.6 0.9 0.0 0.0 0.0 0.1 0.0 0.1 0.0 1.5 0.0 3.3 0.8 0.5 1.6 0.0 5.8 0.0 0.2 3.0 0.3 0.2 EPHB2 "DRT, EPHT3, ERK, Hek5, Tyro5" ENSG00000133216 "EPH receptor B2" P29323 1 22710839-22921500 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" Neurogenesis "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 23.3" "Cell type enhanced" "Detected in many" "Ductal cells: 45.1;Enteroendocrine cells: 48.7;Intestinal goblet cells: 61.1;Oligodendrocytes: 76.3;Pancreatic endocrine cells: 63.7;Undifferentiated cells: 97.2" "Cancer enhanced" "Detected in many" "colorectal cancer: 23.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "GAMG: 86.5;HUVEC TERT2: 74.2;TIME: 79.2;U-251 MG: 69.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "CAB013647, HPA071200" Approved Supported "Nucleoplasm,Plasma membrane" "Intracellular and membrane" No No 380000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 9: Intestine - Unknown function" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" "Plasma membrane" Nucleoplasm "CAB013647: , HPA071200: AB_2686360" "unprognostic (2.47e-2)" "unprognostic (2.43e-2)" "prognostic favorable (4.98e-4)" "prognostic unfavorable (1.05e-5)" "unprognostic (3.99e-2)" "unprognostic (8.91e-3)" "unprognostic (1.23e-1)" "unprognostic (2.33e-3)" "unprognostic (1.56e-1)" "unprognostic (7.73e-2)" "unprognostic (1.23e-2)" "unprognostic (2.15e-2)" "unprognostic (2.16e-4)" "unprognostic (1.45e-1)" "unprognostic (8.07e-2)" "unprognostic (2.58e-1)" "unprognostic (3.46e-2)" 3.1 1.6 2.1 9.2 3.7 0.5 1.6 4.1 4.2 2.5 0.0 22.6 21.0 1.8 1.9 0.6 4.4 3.7 3.3 2.2 4.3 3.8 0.4 1.8 2.9 5.7 4.5 10.6 3.9 6.1 2.9 4.0 4.8 1.9 23.3 2.9 1.5 3.0 0.2 0.9 21.8 3.3 5.0 2.4 1.7 1.8 5.4 1.2 7.3 0.3 1.7 4.4 1.0 8.2 43.4 17.2 17.2 27.7 1.6 1.5 0.0 10.0 0.5 27.3 5.7 6.3 16.6 0.6 20.2 4.0 86.5 39.6 10.8 52.8 7.7 0.1 4.1 0.0 1.9 0.1 16.5 0.0 4.3 5.3 17.5 48.7 0.3 25.4 74.2 2.4 1.8 0.1 5.7 6.4 1.1 0.3 4.0 49.0 11.2 5.3 18.0 0.8 14.7 4.0 18.0 19.3 17.4 0.7 0.2 1.5 1.1 0.5 79.2 11.5 29.6 29.4 69.5 0.0 0.2 0.1 21.8 0.9 0.5 0.1 0.4 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 2.1 3.7 4.1 4.2 2.2 4.3 5.7 4.5 4.8 5.0 5.4 8.2 0.4 3.2 0.0 5.5 0.3 0.8 1.7 20.5 0.0 15.4 0.1 0.1 1.3 7.2 8.6 0.0 0.0 0.5 0.1 24.3 0.0 45.1 2.6 1.0 0.8 1.2 48.7 0.0 34.1 8.0 2.8 5.0 1.1 2.4 0.0 0.5 0.4 0.4 9.6 6.7 32.3 61.1 6.1 7.6 1.4 0.8 0.9 7.2 0.0 21.5 0.7 18.4 0.0 5.5 76.3 63.7 12.6 0.7 0.3 2.3 5.5 0.2 1.7 1.8 0.0 0.6 2.1 0.5 3.5 0.0 0.4 1.1 0.3 0.2 97.2 1.1 EPHB3 "ETK2, Hek2, Tyro6" ENSG00000182580 "EPH receptor B3" P54753 3 184561785-184582408 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted membrane proteins" "Angiogenesis, Neurogenesis" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skin 1: 51.5" "Cell type enhanced" "Detected in many" "Breast glandular cells: 38.1;Breast myoepithelial cells: 50.8;Enteroendocrine cells: 71.5;Intestinal goblet cells: 43.3;Squamous epithelial cells: 44.3;Undifferentiated cells: 55.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 28.8;HaCaT: 40.2;OE19: 28.3;SK-BR-3: 30.9;T-47d: 20.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA007698, HPA008184, CAB034350" Enhanced NA NA 100000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 31: Skin - Epidermis development" "Cluster 28: BEWO - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" "CAB034350: AB_2262377, HPA007698: AB_1848205, HPA008184: AB_1848206" "unprognostic (2.94e-2)" "unprognostic (5.88e-2)" "unprognostic (2.17e-2)" "unprognostic (7.80e-2)" "unprognostic (1.52e-1)" "unprognostic (9.19e-2)" "unprognostic (8.35e-2)" "unprognostic (1.94e-1)" "unprognostic (5.51e-2)" "unprognostic (1.76e-1)" "unprognostic (7.42e-2)" "unprognostic (3.31e-1)" "prognostic unfavorable (7.88e-5)" "unprognostic (8.83e-3)" "unprognostic (3.03e-2)" "unprognostic (9.59e-3)" "unprognostic (2.10e-3)" 1.7 0.7 3.0 3.7 2.7 0.1 10.4 5.8 4.1 22.7 1.0 10.3 6.4 10.1 1.8 30.6 4.0 2.8 1.9 2.9 2.4 5.8 0.9 3.4 0.9 5.7 3.4 8.3 14.9 1.1 2.0 5.7 6.1 10.0 10.9 0.5 31.7 3.5 0.5 51.5 6.3 3.8 2.3 1.0 22.8 0.9 4.0 0.7 0.9 0.4 2.4 4.0 20.9 2.7 6.6 2.3 14.8 1.6 4.5 0.3 28.8 1.1 1.9 2.2 1.2 2.0 0.2 0.0 2.8 6.3 1.0 40.2 5.4 1.9 0.6 0.2 1.1 0.0 0.3 0.0 0.3 0.0 0.2 1.2 13.0 1.8 0.2 0.7 0.0 0.0 0.0 0.0 1.0 17.6 0.0 6.4 1.4 28.3 2.5 1.5 9.0 0.0 0.0 5.8 1.9 2.2 1.2 30.9 1.3 7.8 20.5 0.1 0.0 3.6 5.1 1.8 2.5 0.0 0.0 0.1 0.3 0.0 14.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 2.7 5.8 4.1 2.9 2.4 5.7 3.4 6.1 2.3 4.0 2.7 0.9 3.2 2.7 11.1 0.2 24.1 7.6 5.3 17.1 0.9 38.1 50.8 1.8 2.8 4.6 0.0 0.0 10.1 1.1 21.5 1.9 0.5 0.6 3.7 4.0 1.4 71.5 0.0 4.6 1.6 18.7 6.9 27.0 7.5 4.5 2.1 1.8 0.0 23.5 15.2 5.8 43.3 10.2 0.3 9.8 0.4 2.8 2.4 0.0 1.0 0.8 0.1 0.0 5.0 0.3 3.2 7.2 6.0 0.0 6.0 1.7 0.2 1.4 1.0 0.0 4.5 2.9 0.4 0.6 44.3 35.8 16.3 0.8 1.6 55.0 20.7 EPHB4 "HTK, Tyro11" ENSG00000196411 "EPH receptor B4" P54760 7 100802565-100827523 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" Angiogenesis "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 68.5;Hepatic stellate cells: 113.2;Syncytiotrophoblasts: 206.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "classical monocyte: 2.0;neutrophil: 4.3" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" CAB013537 Uncertain NA NA 1400000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 72: Non-specific - Transcription" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" "CAB013537: " "prognostic unfavorable (8.56e-4)" "unprognostic (1.05e-2)" "prognostic unfavorable (4.33e-4)" "unprognostic (1.33e-1)" "unprognostic (5.23e-2)" "unprognostic (3.43e-2)" "unprognostic (1.46e-1)" "unprognostic (1.01e-1)" "unprognostic (2.73e-1)" "unprognostic (1.84e-1)" "unprognostic (8.16e-3)" "unprognostic (1.43e-1)" "unprognostic (9.51e-3)" "unprognostic (6.63e-2)" "unprognostic (3.13e-1)" "unprognostic (2.07e-2)" "prognostic unfavorable (8.84e-4)" 26.4 49.8 5.0 8.0 4.3 5.6 32.6 4.6 4.8 45.6 6.8 20.7 8.3 61.5 3.8 24.7 27.1 18.0 26.1 4.1 4.1 28.3 33.3 28.2 5.8 5.5 5.1 36.0 26.8 10.1 6.3 35.5 5.3 28.9 10.2 0.3 24.2 22.4 7.7 35.8 17.5 22.2 5.1 47.9 21.4 12.3 6.3 3.1 17.6 13.3 4.9 17.3 28.1 4.8 37.7 33.1 32.5 94.2 20.4 13.0 94.7 14.1 31.2 22.3 29.0 27.4 28.3 4.8 63.6 15.3 31.3 38.2 14.3 38.3 11.9 6.2 25.6 1.3 19.0 43.2 11.8 0.7 0.9 15.3 56.7 14.2 33.1 24.8 84.0 1.5 71.9 1.8 18.4 66.4 0.7 15.0 54.7 56.3 47.5 51.4 15.6 8.9 28.6 19.9 0.2 27.4 22.0 10.4 22.1 45.1 26.1 6.7 71.3 27.6 42.6 51.3 21.4 0.2 0.8 1.7 4.0 12.0 51.2 0.0 2.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 4.3 0.0 0.1 0.1 0.0 0.7 5.0 4.3 4.6 4.8 4.1 4.1 5.5 5.1 5.3 5.1 6.3 4.8 47.1 9.6 12.6 1.6 1.9 20.5 10.3 13.9 15.9 0.1 22.0 19.7 5.7 7.2 8.5 5.5 0.0 68.5 1.1 9.1 0.0 12.3 28.5 4.8 21.8 51.2 3.0 10.8 0.3 6.6 11.2 6.5 12.8 8.0 1.3 10.7 113.2 22.4 9.0 0.0 0.2 17.4 8.2 4.1 3.4 9.9 8.1 1.3 3.6 1.9 1.5 1.7 0.0 0.0 1.0 20.6 7.6 4.1 1.4 13.3 1.3 4.0 4.2 0.2 6.6 5.7 6.3 1.4 10.2 12.1 17.8 206.5 1.2 2.9 19.9 8.0 ERBB2 "CD340, HER-2, HER2, NEU, NGL" ENSG00000141736 "Erb-b2 receptor tyrosine kinase 2" P04626 17 39687914-39730426 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Transcription, Transcription regulation" "Activator, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Collecting duct cells: 136.1;Distal enterocytes: 111.0;Proximal enterocytes: 121.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "gdT-cell: 5.0" "Lineage enriched" "Detected in many" 4 "T-cells: 5.0" "Group enriched" "Detected in many" 41 "OE19: 6565.0;SK-BR-3: 3115.9" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB000043, HPA001060, HPA001338, HPA001383, CAB020416, CAB062555" Enhanced Enhanced "Plasma membrane,Cytosol" NA NA 980000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 7: Kidney - Transmembrane transport" "Cluster 21: OE19 - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" "Plasma membrane" Cytosol "CAB000043: AB_2335701, CAB020416: AB_442047, CAB062555: AB_2665610, HPA001060: AB_2666185, HPA001338: AB_2666279, HPA001383: AB_1078500" "unprognostic (1.97e-1)" "unprognostic (6.60e-3)" "unprognostic (6.21e-2)" "prognostic unfavorable (8.99e-8)" "unprognostic (2.96e-2)" "unprognostic (1.40e-2)" "unprognostic (1.97e-2)" "unprognostic (9.04e-2)" "unprognostic (1.79e-2)" "unprognostic (1.20e-3)" "prognostic unfavorable (9.17e-4)" "unprognostic (3.92e-1)" "prognostic favorable (2.41e-14)" "unprognostic (9.29e-2)" "unprognostic (1.40e-1)" "unprognostic (3.75e-2)" "unprognostic (1.96e-1)" 13.0 5.4 16.1 12.1 20.5 1.6 56.0 14.3 13.1 37.6 23.3 68.2 63.6 25.2 26.6 102.4 64.2 31.0 57.0 13.3 16.0 73.5 31.1 36.2 4.8 22.4 22.7 23.9 37.6 81.7 17.3 27.0 17.1 55.6 48.5 8.1 68.7 50.5 20.7 91.0 67.3 25.0 18.5 6.9 49.7 11.7 15.4 7.4 56.5 15.0 28.0 40.0 52.9 16.4 38.7 45.7 50.4 31.7 59.3 41.2 67.7 27.2 44.9 58.6 48.9 34.4 102.7 2.9 54.6 62.7 31.5 117.6 2.8 61.2 26.9 5.2 38.6 1.8 36.0 56.3 35.3 0.9 1.0 41.0 56.6 36.2 21.9 56.2 24.4 1.9 6.2 2.4 43.3 59.4 7.1 3.0 90.7 6565.0 11.7 3.9 20.5 5.4 58.9 118.9 9.4 2.6 51.5 3115.9 16.9 62.2 88.1 2.2 2.9 30.2 37.7 37.7 17.6 5.3 3.3 3.6 3.0 0.9 98.5 1.1 0.2 0.4 5.0 0.1 0.3 0.6 0.2 1.4 0.2 0.6 0.5 1.4 1.2 0.4 0.1 0.1 0.2 1.7 16.1 20.5 14.3 13.1 13.3 16.0 22.4 22.7 17.1 18.5 15.4 16.4 3.9 41.7 40.1 12.7 2.2 14.0 19.0 37.1 17.6 4.6 62.7 34.9 20.7 32.9 43.8 136.1 12.5 12.0 5.1 111.0 7.9 30.9 0.3 48.7 13.9 6.1 15.6 1.3 0.9 25.5 84.8 15.7 53.5 61.3 0.0 20.3 11.7 10.7 4.0 6.7 1.0 47.5 42.7 2.2 3.1 1.0 18.3 1.7 10.6 1.0 1.2 24.1 26.8 2.0 1.0 32.5 54.8 23.0 1.1 34.9 121.7 19.5 42.0 5.8 0.0 13.1 12.7 6.8 5.7 43.5 18.9 22.7 2.8 4.4 75.4 31.3 ERBB3 "HER3, LCCS2" ENSG00000065361 "Erb-b2 receptor tyrosine kinase 3" P21860 12 56076799-56103505 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal enterocytes: 254.3;Oligodendrocytes: 187.0;Paneth cells: 184.6;Proximal enterocytes: 240.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 4 "basophil: 2.4;neutrophil: 1.0" "Lineage enriched" "Detected in single" 6 "granulocytes: 2.4" "Cell line enhanced" "Detected in many" "Hep G2: 116.4;OE19: 119.1;RT4: 89.7;SK-BR-3: 106.5;SK-MEL-30: 149.5;T-47d: 122.2;WM-115: 153.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025331, HPA045396, HPA070524" Approved Supported "Plasma membrane,Actin filaments" "Secreted - unknown location" NA NA 450000 "Cluster 17: Basophils - Unknown function" "Cluster 45: Intestine - Brush border" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 53: Intestinal epithelial cells - Unknown function" "Plasma membrane" "Actin filaments" "CAB025331: , HPA045396: AB_2679312, HPA070524: " "unprognostic (2.97e-1)" "unprognostic (2.71e-2)" "unprognostic (1.91e-1)" "unprognostic (8.97e-2)" "unprognostic (1.63e-1)" "unprognostic (1.07e-3)" "unprognostic (2.31e-3)" "unprognostic (2.66e-2)" "unprognostic (9.89e-2)" "unprognostic (4.30e-2)" "unprognostic (4.76e-3)" "unprognostic (5.77e-2)" "unprognostic (1.06e-2)" "unprognostic (4.56e-2)" "unprognostic (1.57e-1)" "unprognostic (6.72e-3)" "unprognostic (2.07e-2)" 2.4 2.6 34.4 8.0 69.2 0.9 56.5 45.9 62.0 20.9 10.9 62.9 88.5 5.5 12.3 82.0 12.1 30.6 9.0 39.2 43.1 36.2 98.6 29.3 0.6 59.4 54.4 1.6 57.0 23.8 2.4 13.0 54.7 37.8 64.1 1.3 83.0 18.2 2.4 75.7 82.5 3.8 36.2 0.6 74.7 2.3 55.9 1.0 9.4 1.7 12.5 21.8 44.2 104.9 39.8 2.1 3.2 1.4 0.2 0.1 63.2 3.9 7.2 4.5 4.1 20.4 70.4 0.2 0.8 1.0 0.6 32.2 5.0 7.7 2.3 0.7 3.0 0.1 1.1 116.4 0.1 0.1 0.5 1.3 9.3 0.7 0.3 0.7 0.1 0.8 2.6 1.0 0.4 71.6 0.4 1.3 10.4 119.1 1.9 0.4 7.4 2.1 7.9 89.7 3.3 1.3 2.6 106.5 149.5 9.1 122.2 0.7 0.3 0.5 4.0 1.9 0.5 0.9 0.6 0.6 0.4 0.3 153.4 2.4 0.1 0.3 0.2 0.1 0.1 0.1 0.2 0.1 0.1 0.2 0.2 0.4 1.0 0.4 0.2 0.2 0.3 0.1 34.4 69.2 45.9 62.0 39.2 43.1 59.4 54.4 54.7 36.2 55.9 104.9 0.8 118.6 81.0 1.0 1.5 18.2 15.3 21.6 19.4 1.5 106.4 47.8 1.9 171.6 74.6 35.0 2.1 52.6 2.0 254.3 1.9 60.1 1.3 36.1 10.9 2.7 93.1 2.7 0.7 88.1 84.6 4.5 96.4 95.9 1.3 0.7 5.0 112.0 6.1 0.0 2.0 145.2 40.7 1.9 3.7 0.5 1.5 1.5 55.2 1.0 1.7 7.7 0.0 49.8 187.0 94.8 184.6 0.0 0.3 103.3 240.2 30.0 54.8 1.1 6.6 4.5 3.4 9.5 13.4 87.7 36.9 100.6 2.5 0.1 136.9 135.4 ERBB4 "ALS19, HER4" ENSG00000178568 "Erb-b2 receptor tyrosine kinase 4" Q15303 2 211375717-212538841 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Apoptosis, Lactation, Transcription, Transcription regulation" "Activator, Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Amyotrophic lateral sclerosis, Cancer-related genes, Disease variant, FDA approved drug targets, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 16.9;fallopian tube: 11.2" "Cell type enhanced" "Detected in many" "Astrocytes: 2020.2;Inhibitory neurons: 6091.7;Oligodendrocyte precursor cells: 2369.0;Oligodendrocytes: 1049.9" "Group enriched" "Detected in many" 4 "breast cancer: 4.1;endometrial cancer: 2.1;glioma: 1.2;ovarian cancer: 2.8;testis cancer: 1.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 6.9;EFO-21: 5.1;HEK 293: 3.8;RPTEC TERT1: 5.6;SCLC-21H: 3.1;T-47d: 5.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000276, HPA012016, CAB025522" Enhanced NA NA 220000 "Cluster 57: Non-specific - Angiogenesis" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB000276: , CAB025522: , HPA012016: AB_1846541" "unprognostic (1.48e-1)" "unprognostic (3.28e-1)" "unprognostic (4.31e-3)" "unprognostic (1.76e-3)" "unprognostic (3.59e-1)" "unprognostic (2.75e-1)" "unprognostic (2.88e-1)" "unprognostic (9.56e-2)" "unprognostic (2.07e-1)" "unprognostic (4.67e-3)" "unprognostic (1.07e-1)" "unprognostic (3.61e-1)" "unprognostic (7.14e-3)" "unprognostic (1.49e-3)" "unprognostic (1.41e-1)" "unprognostic (1.14e-1)" "unprognostic (4.11e-2)" 0.3 0.4 10.0 0.0 13.3 0.0 5.6 10.5 11.5 2.9 0.0 0.1 0.0 0.2 0.0 0.1 11.2 0.0 3.0 9.9 12.7 5.1 0.0 0.8 0.0 4.9 16.9 0.1 0.6 3.1 2.4 0.1 7.6 0.3 0.0 2.0 4.7 1.2 1.5 0.3 0.0 0.0 4.3 0.0 0.4 3.3 8.0 0.0 1.6 1.7 0.0 0.1 0.1 6.1 0.0 0.0 6.9 0.2 0.0 0.0 0.0 0.0 0.2 0.3 0.1 0.0 0.0 0.0 5.1 0.7 0.0 0.3 0.2 0.0 0.0 0.1 3.8 0.0 1.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 2.1 0.0 0.0 0.3 0.0 5.6 0.3 3.1 0.2 0.0 0.1 0.1 0.1 5.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.0 13.3 10.5 11.5 9.9 12.7 4.9 16.9 7.6 4.3 8.0 6.1 0.4 0.0 12.6 2020.2 0.0 0.6 0.9 1.1 0.6 15.9 45.6 17.0 27.2 0.0 10.2 12.9 0.0 0.0 0.2 0.0 5.9 0.5 6.7 25.4 1.0 1.0 0.0 0.0 62.0 0.5 0.2 1.8 0.0 25.8 0.0 5.4 0.0 0.0 0.1 0.0 6091.7 0.0 2.0 0.0 0.3 2.2 1.8 0.3 3.6 96.5 0.0 9.1 0.0 2369.0 1049.9 0.0 0.0 0.4 0.0 1.6 0.0 0.2 28.1 1.9 6.6 4.1 3.0 1.8 2.6 0.2 1.3 0.0 0.2 0.0 0.0 1.2 ERN1 "IRE1, IRE1P" ENSG00000178607 "Endoplasmic reticulum to nucleus signaling 1" O75460 17 64039080-64130819 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Apoptosis, Transcription, Transcription regulation, Unfolded protein response" "Hydrolase, Kinase, Multifunctional enzyme, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 53.0;pancreas: 66.7" "Cell type enhanced" "Detected in many" "Plasma cells: 325.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 17.9" "Group enriched" "Detected in many" 5 "dendritic cells: 7.7;granulocytes: 17.9;T-cells: 9.0" "Cell line enhanced" "Detected in many" "Karpas-707: 74.6;RPMI-8226: 40.2;U-266/70: 77.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009495, HPA027730" Supported NA Yes "Cluster 38: Basophils - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 29: U-266 - Adaptive immune response" "Cluster 55: Plasma cells - Humoral immune response" "CAB009495: AB_2098712, HPA027730: AB_10602494" "unprognostic (2.52e-1)" "unprognostic (1.16e-2)" "unprognostic (1.89e-1)" "unprognostic (4.05e-3)" "unprognostic (3.63e-2)" "unprognostic (2.81e-2)" "unprognostic (9.14e-2)" "unprognostic (2.72e-2)" "unprognostic (4.55e-1)" "unprognostic (6.17e-2)" "unprognostic (2.95e-1)" "unprognostic (1.33e-1)" "prognostic unfavorable (1.68e-4)" "unprognostic (4.65e-1)" "unprognostic (1.89e-1)" "unprognostic (1.36e-2)" "unprognostic (3.11e-2)" 9.5 53.0 1.5 5.4 1.7 13.4 7.5 2.6 3.2 22.6 2.1 7.7 6.3 10.1 6.4 9.5 14.3 6.2 6.1 1.6 2.4 5.6 23.5 16.5 5.8 1.7 1.0 16.9 66.7 4.3 19.5 5.6 1.3 9.9 4.5 8.8 15.7 7.1 6.8 11.3 10.6 5.6 1.0 15.8 16.2 2.8 1.6 6.8 10.2 2.4 6.6 8.3 11.7 1.7 4.0 4.0 2.2 4.8 4.8 4.4 9.8 4.1 9.7 2.8 1.3 2.5 2.3 6.6 3.2 2.8 3.5 3.6 1.9 4.5 6.1 1.6 1.5 6.0 3.2 2.4 19.6 3.2 2.1 3.8 8.1 6.4 21.5 3.5 5.0 4.7 4.2 74.6 2.8 3.9 4.5 1.0 0.6 3.6 3.2 4.2 4.2 40.2 1.1 5.5 7.1 3.5 4.3 6.1 5.7 3.5 3.8 5.9 5.9 2.5 4.1 6.4 2.7 77.4 23.9 4.8 4.0 2.1 4.2 17.9 0.9 0.4 4.9 0.4 9.0 0.2 3.3 4.1 0.4 0.3 0.9 0.9 4.9 2.5 0.3 7.7 0.8 1.0 1.5 1.7 2.6 3.2 1.6 2.4 1.7 1.0 1.3 1.0 1.6 1.7 31.9 0.0 36.1 7.2 27.8 22.0 54.3 8.3 15.4 4.0 35.0 29.7 8.6 11.5 8.6 12.9 6.2 8.1 106.4 10.0 1.9 12.6 2.3 26.1 49.1 18.3 79.7 11.2 8.6 27.3 8.8 42.2 52.0 79.4 8.2 11.8 13.9 26.8 8.0 3.3 6.1 8.2 8.2 15.7 71.3 1.7 4.7 60.4 74.7 12.2 10.2 3.5 28.8 6.0 4.6 17.9 7.3 6.0 325.8 44.7 7.9 4.4 6.1 26.5 0.0 19.0 25.7 4.0 4.1 27.7 45.0 54.9 88.2 12.0 9.6 60.1 ERN2 IRE1b ENSG00000134398 "Endoplasmic reticulum to nucleus signaling 2" Q76MJ5 16 23690310-23713226 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Transcription, Transcription regulation" "Hydrolase, Kinase, Multifunctional enzyme, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "cervix: 19.5;gallbladder: 17.0;intestine: 28.9;salivary gland: 22.9;stomach 1: 51.9" "Cell type enhanced" "Detected in some" "Club cells: 38.4;Distal enterocytes: 80.2;Gastric mucus-secreting cells: 193.7;Intestinal goblet cells: 143.9;Paneth cells: 37.2;Undifferentiated cells: 70.9" "Cancer enhanced" "Detected in many" "colorectal cancer: 17.0;pancreatic cancer: 19.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 6 "OE19: 43.6" "Not detected" "Not detected" "Not detected" "Not detected" HPA076875 Approved Approved "Endoplasmic reticulum,Cytosol" "Intracellular and membrane" NA NA "Cluster 11: Basophils - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 21: OE19 - Mitochondria" "Cluster 27: Mucus-secreting cells - Mucin production" "Endoplasmic reticulum, Cytosol" "HPA076875: " "unprognostic (1.06e-1)" "unprognostic (5.20e-2)" "unprognostic (3.45e-1)" "unprognostic (2.98e-2)" "unprognostic (3.83e-2)" "unprognostic (1.13e-2)" "unprognostic (7.67e-4)" "unprognostic (1.31e-1)" "unprognostic (1.16e-1)" "unprognostic (4.93e-2)" "unprognostic (7.34e-2)" "unprognostic (1.19e-1)" "unprognostic (1.14e-9)" "unprognostic (1.48e-1)" "unprognostic (2.14e-1)" "unprognostic (1.06e-1)" "unprognostic (3.13e-3)" 0.1 0.4 0.1 3.0 0.1 0.0 0.1 0.6 0.4 19.5 0.2 28.9 12.9 0.0 0.0 0.9 0.4 17.0 0.0 0.1 0.2 0.1 0.0 0.8 0.0 0.2 0.1 0.0 0.9 0.0 0.2 0.0 0.2 3.5 23.0 0.0 22.9 0.1 0.0 0.2 12.4 0.9 0.0 0.0 51.9 0.1 0.1 0.0 0.0 0.0 0.0 4.6 0.3 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 6.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 43.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.2 0.0 0.1 0.0 0.0 0.1 0.1 0.6 0.4 0.1 0.2 0.2 0.1 0.2 0.0 0.1 0.4 0.0 0.0 1.1 0.0 0.8 0.0 1.5 6.8 0.0 0.0 0.0 0.0 0.5 20.0 38.4 0.0 0.0 0.5 0.0 80.2 0.0 2.3 0.1 0.5 0.2 0.1 10.8 0.0 0.2 1.9 0.0 0.1 193.7 1.6 4.5 0.1 0.0 0.0 0.1 0.0 0.1 143.9 6.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.0 0.1 33.1 37.2 0.0 0.5 1.3 6.1 0.1 16.9 0.0 0.0 1.7 1.6 0.0 0.2 0.0 0.0 0.1 0.4 0.0 70.9 11.1 ETNK1 "EKI, EKI1" ENSG00000139163 "Ethanolamine kinase 1" Q9HBU6 12 22625075-22690665 "Cancer-related genes, Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 299.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA010712, HPA029407" Approved Approved "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 45: Intestine - Brush border" "Cluster 5: NTERA-2 - Transcription" "Cluster 23: Spermatids - Flagellum & Golgi organization" "Nucleoplasm, Plasma membrane, Cytosol" "HPA010712: AB_2668349, HPA029407: AB_2673026" "unprognostic (2.06e-1)" "unprognostic (7.48e-2)" "unprognostic (1.23e-3)" "unprognostic (2.19e-1)" "unprognostic (8.79e-3)" "unprognostic (1.31e-2)" "prognostic unfavorable (5.85e-4)" "unprognostic (3.98e-3)" "unprognostic (8.30e-2)" "unprognostic (7.97e-3)" "unprognostic (2.01e-1)" "unprognostic (1.64e-2)" "unprognostic (4.53e-3)" "unprognostic (2.77e-1)" "unprognostic (2.91e-1)" "unprognostic (3.01e-1)" "prognostic favorable (1.75e-4)" 10.1 14.4 13.7 14.5 15.2 12.2 13.7 9.0 15.9 10.8 16.4 27.2 23.3 10.2 19.6 10.8 10.1 14.0 7.3 14.7 28.1 18.4 18.2 12.6 17.4 12.0 14.2 11.7 10.7 10.8 13.7 11.3 15.8 10.9 15.3 18.2 12.4 6.2 6.2 15.3 15.5 7.6 11.1 16.7 45.0 17.8 19.3 23.1 14.5 5.6 14.3 10.8 9.5 17.5 14.8 27.9 30.4 27.5 21.2 21.3 21.7 15.6 12.2 17.4 16.0 20.6 33.3 41.1 14.7 11.6 16.5 10.7 27.1 7.6 28.2 36.8 23.7 34.7 11.5 18.9 20.6 33.9 29.4 13.7 7.2 21.9 17.4 25.8 20.3 15.7 41.8 17.2 22.3 7.7 38.8 67.1 59.3 17.9 20.1 32.7 28.1 32.9 25.6 16.5 9.8 17.8 18.9 13.9 27.1 41.1 24.1 32.1 17.5 12.2 19.9 18.6 25.0 12.9 18.1 46.8 16.2 21.0 23.9 44.0 14.3 15.9 15.4 22.0 15.2 22.2 16.4 14.4 14.1 15.3 17.7 17.7 14.6 17.7 23.4 12.6 20.5 19.2 13.7 15.2 9.0 15.9 14.7 28.1 12.0 14.2 15.8 11.1 19.3 17.5 33.6 48.1 32.2 48.0 55.9 144.3 75.7 34.7 64.9 41.0 56.8 42.2 10.1 45.8 43.8 44.1 50.1 30.1 57.6 116.1 27.4 30.7 299.0 64.2 49.1 34.8 108.3 48.8 104.4 44.5 24.2 38.2 230.4 51.4 34.8 40.9 28.2 41.5 42.9 26.9 104.3 60.7 46.8 88.3 60.0 43.5 24.2 57.0 67.6 84.3 39.1 17.7 43.3 121.2 152.9 39.5 62.9 21.4 63.7 73.8 57.7 33.2 81.6 39.5 39.5 23.3 38.9 49.1 18.5 51.9 170.2 75.4 49.0 41.5 47.8 90.3 ETNK2 "EKI2, FLJ10761" ENSG00000143845 "Ethanolamine kinase 2" Q9NVF9 1 204131062-204152044 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 4 "kidney: 108.1;liver: 235.5;testis: 125.0" "Group enriched" "Detected in many" 4 "Early spermatids: 417.0;Late spermatids: 1337.3" "Cancer enhanced" "Detected in all" "liver cancer: 32.3" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "hTCEpi: 53.8;MCF7: 55.1" "Low region specificity" "Detected in many" "Region enriched" "Detected in many" 8 "basal ganglia: 22.6" HPA057167 Enhanced NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 25: Spermatids - Spermatogenesis" "HPA057167: AB_2683358" "unprognostic (1.64e-1)" "unprognostic (4.17e-2)" "unprognostic (2.56e-2)" "unprognostic (7.81e-2)" "prognostic unfavorable (4.11e-4)" "unprognostic (1.95e-1)" "unprognostic (1.99e-2)" "unprognostic (1.13e-1)" "unprognostic (9.39e-3)" "unprognostic (4.28e-2)" "unprognostic (6.54e-2)" "unprognostic (4.35e-2)" "prognostic favorable (6.50e-4)" "unprognostic (5.50e-3)" "unprognostic (4.69e-2)" "unprognostic (2.00e-2)" "unprognostic (1.20e-1)" 14.4 6.1 12.8 2.1 12.5 2.8 17.4 7.9 12.0 18.8 28.3 5.7 1.9 10.8 29.9 23.9 13.1 5.3 6.3 10.6 14.0 108.1 235.5 3.3 2.1 10.5 13.4 36.1 9.5 18.5 25.6 4.3 11.1 13.7 2.1 5.7 27.7 16.2 2.0 20.3 3.7 6.5 8.5 7.2 4.9 125.0 15.1 3.7 10.6 4.1 9.3 10.0 26.0 7.5 11.3 3.8 11.0 20.9 4.0 1.3 10.9 11.4 25.2 15.6 6.8 19.2 5.4 0.4 18.4 2.8 18.2 9.9 19.7 15.9 10.7 0.4 17.3 0.2 2.5 30.6 16.2 0.5 0.7 5.4 53.8 3.2 0.7 8.0 11.1 11.9 1.6 0.4 2.0 55.1 3.2 0.3 23.0 0.4 8.4 0.8 13.0 0.4 13.4 4.3 2.9 15.4 7.2 33.6 5.4 35.1 32.5 0.7 0.7 4.4 23.8 1.0 8.4 0.5 0.2 0.5 0.3 0.6 6.3 0.0 0.1 0.0 2.2 0.0 2.1 0.0 0.5 1.3 0.0 0.1 1.3 1.6 0.1 0.8 0.0 0.0 0.3 0.6 12.8 12.5 7.9 12.0 10.6 14.0 10.5 13.4 11.1 8.5 15.1 7.5 1.3 0.0 0.0 1.3 1.0 4.1 13.8 8.2 1.8 4.2 12.3 11.6 1.1 4.3 2.5 3.7 4.2 6.1 1.6 0.1 39.2 9.5 417.0 4.5 1.9 2.1 1.2 13.5 1.2 6.3 9.2 6.4 1.1 3.2 8.9 47.4 6.8 196.9 0.8 0.0 2.9 0.1 2.0 6.5 1.1 1337.3 29.2 1.6 10.6 0.0 0.0 3.8 1.0 2.5 0.2 4.5 0.0 42.2 0.0 14.9 0.3 147.2 3.1 0.8 0.0 4.1 4.4 11.0 7.4 16.1 2.4 9.4 2.9 34.1 0.2 13.5 EXT1 "LGCR, LGS, ttv" ENSG00000182197 "Exostosin glycosyltransferase 1" Q16394 8 117794490-118111826 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cancer-related genes, Disease variant, Hereditary multiple exostoses, Tumor suppressor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 229.6;Inhibitory neurons: 421.4;Microglial cells: 144.3;Oligodendrocyte precursor cells: 162.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ hTERT+: 95.5;fHDF/TERT166: 82.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044394 Uncertain NA Yes 17000000 "Cluster 7: Monocytes - Unknown function" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA044394: AB_10963838" "unprognostic (1.29e-2)" "prognostic unfavorable (7.04e-4)" "unprognostic (2.73e-2)" "unprognostic (2.02e-3)" "unprognostic (2.19e-1)" "unprognostic (7.55e-2)" "unprognostic (1.99e-1)" "prognostic unfavorable (1.20e-5)" "unprognostic (1.70e-1)" "unprognostic (3.01e-2)" "unprognostic (1.31e-2)" "unprognostic (6.58e-2)" "unprognostic (1.27e-2)" "unprognostic (9.84e-2)" "unprognostic (9.49e-2)" "prognostic unfavorable (4.64e-4)" "unprognostic (1.85e-1)" 5.1 4.2 2.0 5.2 2.5 1.1 4.3 2.3 2.3 7.6 3.9 7.7 14.1 4.9 2.9 5.5 3.8 5.8 7.0 3.4 1.3 3.8 13.3 7.9 3.0 1.1 2.1 5.0 5.5 3.3 1.8 11.1 1.0 5.0 8.2 2.7 3.2 7.7 1.5 7.8 11.7 6.1 1.4 5.1 5.3 2.4 1.2 3.0 5.2 2.4 3.8 11.8 4.2 1.9 29.3 8.5 13.5 5.5 22.8 23.0 5.9 51.5 95.5 40.9 39.4 10.0 3.1 0.5 24.8 82.1 24.0 19.8 5.0 31.4 55.7 12.5 9.9 1.5 5.9 6.5 10.0 0.0 1.6 10.8 10.8 38.8 38.5 47.7 28.1 2.9 0.9 7.4 18.7 3.2 1.8 0.2 4.6 13.7 10.1 0.0 4.1 1.3 23.1 7.6 4.5 4.0 8.0 3.9 9.2 32.6 5.3 0.5 32.0 35.2 28.7 32.0 15.8 5.5 5.1 2.4 36.5 0.0 9.2 0.1 0.4 0.0 0.0 0.6 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.2 0.4 0.2 0.3 0.1 2.0 2.5 2.3 2.3 3.4 1.3 1.1 2.1 1.0 1.4 1.2 1.9 21.1 19.2 6.0 127.3 3.0 54.8 23.0 27.7 10.2 23.6 7.8 10.8 6.5 24.3 13.7 7.3 14.6 6.5 5.1 49.2 0.0 37.3 1.8 17.7 37.1 25.9 4.8 1.7 229.6 20.1 3.9 32.6 11.7 18.2 7.0 108.3 16.8 32.9 2.5 10.1 421.4 25.5 4.1 37.9 13.9 2.7 17.4 9.6 19.6 144.3 8.1 5.9 4.1 162.8 101.8 27.4 16.1 36.1 5.3 19.3 44.9 4.9 14.2 22.4 0.0 17.1 36.4 0.6 5.1 12.6 47.3 12.2 4.2 35.0 26.3 26.8 EXT2 SOTV ENSG00000151348 "Exostosin glycosyltransferase 2" Q93063 11 44095673-44251962 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cancer-related genes, Disease variant, Epilepsy, Hereditary multiple exostoses, Mental retardation, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA078409 Supported "Golgi apparatus" NA NA 39000000 "Cluster 27: Non-specific - Gene expression" "Cluster 46: Fibroblasts - ECM organization" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 33: Fibroblasts - ECM organization" "Golgi apparatus" "HPA078409: AB_2686884" "unprognostic (5.87e-2)" "unprognostic (3.05e-3)" "unprognostic (3.48e-2)" "unprognostic (3.94e-1)" "unprognostic (1.42e-1)" "prognostic unfavorable (2.50e-4)" "unprognostic (1.77e-3)" "unprognostic (2.22e-2)" "unprognostic (1.97e-1)" "unprognostic (2.05e-1)" "unprognostic (1.74e-3)" "unprognostic (3.70e-2)" "prognostic unfavorable (5.36e-6)" "unprognostic (7.07e-3)" "unprognostic (2.97e-1)" "unprognostic (3.85e-1)" "unprognostic (1.36e-2)" 33.5 22.8 14.4 22.1 15.4 11.2 29.3 15.4 16.3 36.1 17.5 29.1 26.5 43.1 33.3 20.1 33.7 28.1 27.3 15.6 18.1 26.5 26.9 27.9 16.0 15.5 16.0 33.5 26.5 28.9 20.1 61.9 15.5 29.8 28.7 20.9 26.7 30.2 16.2 25.8 31.0 49.3 14.7 21.6 23.8 21.6 19.4 15.2 27.6 18.4 17.3 29.7 28.5 16.1 57.9 71.6 38.3 121.5 170.4 124.2 60.8 181.1 198.0 93.1 125.1 51.2 36.5 40.4 82.1 188.8 98.5 90.0 41.0 114.0 110.0 83.2 71.5 38.4 33.7 39.7 67.5 37.5 76.6 97.7 73.4 56.3 86.6 108.8 132.7 34.8 50.0 63.9 68.4 40.3 25.9 22.3 43.8 67.1 70.9 32.3 116.1 21.1 53.9 49.1 30.9 35.5 118.1 41.4 28.1 67.0 69.8 37.2 137.8 127.4 90.6 133.1 111.4 33.4 46.0 30.4 84.7 27.9 140.0 15.2 17.5 19.4 20.9 17.7 23.5 9.0 16.5 19.3 21.3 8.8 15.4 15.2 3.4 26.3 12.8 7.4 14.2 15.5 14.4 15.4 15.4 16.3 15.6 18.1 15.5 16.0 15.5 14.7 19.4 16.1 24.5 16.0 10.6 41.4 8.7 15.2 17.3 22.0 10.8 11.5 11.0 11.4 10.2 8.6 13.5 12.9 14.6 34.3 10.6 21.1 5.9 33.5 43.2 7.9 17.1 19.2 1.8 6.7 64.3 23.7 37.0 32.3 7.7 11.5 6.3 22.7 22.9 18.3 18.3 13.5 63.3 12.9 12.2 10.8 7.2 23.0 27.4 10.4 5.4 28.1 10.2 17.4 7.2 50.3 51.8 24.0 14.9 28.6 7.0 23.6 31.6 8.2 8.1 15.0 19.7 15.8 20.7 51.2 24.4 10.2 12.6 35.3 9.2 12.2 15.0 15.3 EXTL1 "EXTL, MGC70794" ENSG00000158008 "Exostosin like glycosyltransferase 1" Q92935 1 26019884-26036464 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "brain: 14.2;skeletal muscle: 12.7;tongue: 29.8" "Cell type enhanced" "Detected in some" "Bipolar cells: 15.3;Breast glandular cells: 8.8;Excitatory neurons: 22.7;Horizontal cells: 10.1;Melanocytes: 7.2;Oligodendrocyte precursor cells: 10.6" "Cancer enriched" "Detected in some" 13 "melanoma: 21.7" "Group enriched" "Detected in many" 11 "amygdala: 10.3;basal ganglia: 9.8;cerebral cortex: 14.2;hippocampal formation: 11.5;white matter: 6.9" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 10 "WM-115: 150.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA010726, HPA037749" Uncertain Approved Vesicles,Centrosome "Intracellular and membrane" NA NA 79000 "Cluster 47: Non-specific - Unknown function" "Cluster 17: WM-115 - Nervous system development" "Cluster 30: Mammary glandular cells - Lactation" Centrosome Vesicles "HPA010726: , HPA037749: AB_10805350" "unprognostic (2.00e-1)" "unprognostic (1.10e-2)" "unprognostic (8.16e-3)" "unprognostic (1.47e-2)" "unprognostic (2.47e-2)" "unprognostic (6.14e-3)" "unprognostic (3.78e-2)" "unprognostic (1.99e-1)" "unprognostic (1.99e-1)" "unprognostic (6.70e-2)" "unprognostic (1.44e-2)" "unprognostic (3.46e-1)" "unprognostic (1.12e-2)" "unprognostic (1.40e-3)" "unprognostic (2.27e-2)" "unprognostic (2.91e-1)" "unprognostic (1.35e-2)" 0.2 1.0 10.3 0.0 9.8 0.0 0.8 0.0 14.2 0.4 0.0 1.0 0.1 3.6 0.1 0.5 0.7 0.3 3.5 11.5 0.0 0.4 0.0 0.2 0.2 0.1 0.6 1.1 1.5 0.0 0.9 0.3 0.4 0.4 0.0 0.8 0.5 0.2 12.7 2.3 0.3 1.3 0.0 3.5 0.3 0.6 0.9 0.0 0.2 29.8 0.0 0.3 0.4 6.9 0.2 0.0 0.1 0.6 0.0 0.0 0.0 0.7 0.4 0.0 0.0 0.0 0.0 0.1 0.1 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.9 0.0 0.0 0.0 0.7 0.0 0.2 0.2 0.1 0.7 0.0 0.0 0.0 0.2 0.0 0.0 0.0 14.7 0.0 0.0 0.0 0.2 0.6 0.0 0.2 2.4 0.2 0.7 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.0 150.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.3 9.8 0.0 14.2 11.5 0.0 0.1 0.6 0.4 0.0 0.9 6.9 0.1 0.0 0.0 2.3 0.0 0.1 0.0 0.0 0.0 15.3 8.8 1.8 3.8 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.1 0.6 0.1 0.0 0.0 22.7 0.0 0.0 0.4 0.0 0.2 0.0 0.4 0.0 0.0 0.1 10.1 5.1 0.0 0.0 0.0 0.3 0.6 1.5 0.0 7.2 2.8 0.0 0.4 0.0 10.6 1.9 0.0 0.0 2.6 0.0 0.0 0.1 0.0 0.0 1.2 0.0 0.4 0.4 0.2 0.2 0.0 0.0 1.0 0.0 1.1 0.1 0.1 EXTL2 ENSG00000162694 "Exostosin like glycosyltransferase 2" Q9UBQ6 1 100872372-100895179 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 214.1;Theca cells: 328.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB020716, HPA068921" Approved Approved Nucleoplasm,Cytosol "Intracellular and membrane" NA NA 80000000 "Cluster 40: NK-cells - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 12: NES - Nervous system development" "Cluster 47: Cytotrophoblasts - Unknown function" Nucleoplasm Cytosol "CAB020716: , HPA068921: AB_2686058" "unprognostic (3.14e-1)" "unprognostic (6.34e-2)" "unprognostic (1.50e-2)" "unprognostic (8.20e-2)" "unprognostic (9.07e-3)" "unprognostic (1.25e-1)" "prognostic unfavorable (1.64e-5)" "unprognostic (7.81e-3)" "unprognostic (1.10e-2)" "unprognostic (1.28e-1)" "unprognostic (3.61e-2)" "unprognostic (3.00e-1)" "unprognostic (3.17e-2)" "unprognostic (6.84e-2)" "unprognostic (7.83e-2)" "unprognostic (1.24e-2)" "unprognostic (4.34e-2)" 8.8 24.6 11.4 5.0 15.0 2.2 11.5 12.0 16.4 13.9 19.1 10.8 4.8 18.1 13.7 6.5 10.9 11.4 9.2 10.3 15.4 12.9 12.6 8.4 4.2 12.9 14.9 19.6 9.0 14.6 12.9 24.9 13.7 13.4 7.6 13.9 7.1 11.9 6.9 6.5 5.4 17.0 11.2 6.5 7.3 10.7 17.8 8.2 10.1 7.1 3.7 9.2 6.9 11.3 13.0 6.9 50.2 50.7 53.2 39.3 31.4 23.2 37.5 17.5 39.4 6.1 9.9 15.2 21.8 20.9 13.5 12.7 18.3 19.6 35.4 31.8 13.4 19.0 23.6 18.3 17.5 28.9 9.3 47.3 6.8 35.9 6.6 36.5 65.0 19.2 23.9 2.0 45.1 6.9 15.5 15.5 62.2 12.2 15.5 11.2 51.5 12.1 18.4 9.7 20.6 57.5 17.4 4.6 42.0 35.8 10.9 12.7 27.7 44.0 25.8 27.8 24.4 15.5 15.0 9.8 69.2 29.3 14.4 2.0 0.5 0.0 3.4 0.7 1.5 1.2 1.1 2.3 1.7 1.7 1.2 2.7 0.1 3.9 0.5 4.6 0.0 1.2 11.4 15.0 12.0 16.4 10.3 15.4 12.9 14.9 13.7 11.2 17.8 11.3 12.3 12.8 8.4 39.8 4.9 8.5 10.2 13.8 21.1 20.7 13.2 13.5 12.7 10.0 11.0 14.7 35.5 214.1 5.0 3.3 11.7 5.8 45.3 20.3 28.7 13.1 9.5 16.2 47.1 2.1 36.9 36.0 15.3 11.0 17.7 35.3 13.6 16.4 24.3 3.3 49.9 5.6 12.2 7.3 5.7 34.9 25.1 5.8 23.2 12.2 7.4 18.8 8.2 40.7 32.9 2.4 2.6 34.6 5.9 6.2 2.9 11.9 25.3 19.7 13.1 25.4 22.4 37.1 12.3 8.5 8.1 74.3 6.1 328.5 7.1 4.9 EXTL3 "botv, REGR" ENSG00000012232 "Exostosin like glycosyltransferase 3" O43909 8 28600469-28755599 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Disease variant, Dwarfism, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 5.7" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB025387 Approved NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 38: Heart - Muscle contraction" "Cluster 38: EFO-21 - Unknown function" "Cluster 23: Spermatids - Flagellum & Golgi organization" "CAB025387: " "unprognostic (1.35e-1)" "unprognostic (1.31e-1)" "unprognostic (5.53e-2)" "unprognostic (1.19e-3)" "unprognostic (9.83e-2)" "unprognostic (2.41e-1)" "prognostic unfavorable (1.14e-5)" "unprognostic (4.25e-2)" "unprognostic (9.29e-3)" "unprognostic (1.05e-1)" "unprognostic (5.10e-3)" "unprognostic (1.19e-3)" "prognostic favorable (2.47e-5)" "unprognostic (1.34e-1)" "unprognostic (1.73e-1)" "unprognostic (8.91e-2)" "unprognostic (1.39e-2)" 10.8 16.5 11.3 7.2 12.0 3.8 6.3 7.6 13.7 8.9 5.8 11.1 5.5 13.8 5.4 12.3 11.3 7.9 31.1 14.7 10.4 7.0 6.2 8.6 5.4 10.7 14.3 10.0 11.9 18.9 10.3 13.8 7.2 8.5 5.4 11.2 8.1 11.8 20.8 11.1 6.7 17.9 8.9 8.6 9.0 10.3 23.4 6.4 7.7 22.7 4.8 10.6 7.2 12.7 45.3 33.6 70.1 37.0 18.8 18.5 15.6 33.7 32.6 20.3 16.4 28.9 15.9 12.2 46.6 40.1 28.2 29.7 34.5 55.1 22.4 8.9 18.9 17.2 15.7 14.3 9.8 8.6 46.9 22.2 36.7 15.9 14.6 16.9 44.3 17.4 16.2 15.4 16.5 8.5 15.5 4.7 49.2 13.3 13.6 18.4 31.3 7.1 31.2 29.0 15.2 26.6 14.3 8.6 17.3 22.0 8.4 9.4 34.9 26.6 62.7 25.4 28.9 7.9 17.9 13.5 22.5 10.3 23.7 3.0 1.3 2.0 1.7 0.9 0.8 0.3 0.7 0.9 1.3 0.4 0.5 0.4 5.7 0.5 1.4 1.1 0.3 0.8 11.3 12.0 7.6 13.7 14.7 10.4 10.7 14.3 7.2 8.9 23.4 12.7 6.3 3.2 4.4 10.4 2.4 5.0 2.9 8.7 6.8 17.5 4.8 4.2 26.8 7.2 5.0 1.8 25.0 3.7 7.1 4.9 3.9 9.7 32.0 4.2 7.0 7.3 4.2 1.3 20.0 10.6 16.9 6.5 4.1 5.9 5.7 3.0 8.2 9.0 4.4 8.4 19.0 2.4 2.0 6.6 2.5 10.1 9.9 6.1 5.4 16.9 5.7 6.7 23.7 13.0 16.6 12.3 2.4 14.3 4.2 6.3 2.1 3.5 4.9 16.2 26.3 8.4 9.6 4.3 9.1 4.3 3.0 2.2 4.5 8.6 3.1 3.1 EZH1 "KIAA0388, KMT6B" ENSG00000108799 "Enhancer of zeste 1 polycomb repressive complex 2 subunit" Q92800 17 42700275-42745049 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" "Chromatin regulator, Methyltransferase, Repressor, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "retina: 133.4" "Cell type enhanced" "Detected in many" "Rod photoreceptor cells: 258.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "ASC diff: 48.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005478, HPA077684" Supported Supported Nucleoplasm NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 54: Non-specific - Microtubule organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 46: Photoreceptor cells - Phototransduction" Nucleoplasm "HPA005478: AB_1848340, HPA077684: AB_2732356" "unprognostic (1.01e-1)" "unprognostic (6.02e-2)" "unprognostic (2.19e-2)" "unprognostic (8.57e-2)" "unprognostic (1.89e-1)" "unprognostic (1.84e-3)" "unprognostic (1.76e-2)" "unprognostic (1.18e-2)" "unprognostic (1.25e-1)" "unprognostic (1.55e-3)" "unprognostic (5.22e-3)" "unprognostic (4.11e-3)" "unprognostic (1.48e-2)" "unprognostic (4.60e-2)" "unprognostic (3.29e-1)" "unprognostic (5.39e-2)" "unprognostic (4.74e-2)" 39.6 18.1 35.0 14.4 37.4 15.2 34.1 42.4 41.5 41.5 29.4 31.6 13.0 31.1 26.5 21.6 35.6 12.8 31.8 33.9 33.9 28.6 13.4 25.7 20.5 37.7 36.5 47.8 18.3 25.5 26.3 12.5 40.2 26.0 15.4 133.4 20.2 23.8 43.8 26.1 30.6 20.4 32.3 37.8 20.7 12.0 35.8 22.9 28.4 33.2 20.4 29.2 31.4 41.5 8.9 9.3 12.4 8.5 48.4 29.1 10.4 14.0 12.7 11.4 11.6 4.4 10.8 13.4 8.6 15.0 11.2 19.8 8.1 9.2 16.3 15.0 14.5 4.7 19.7 5.4 16.6 10.2 10.8 16.7 16.6 8.6 20.8 20.0 9.4 13.4 12.5 18.5 10.2 3.7 16.6 12.9 3.4 8.2 4.7 10.7 12.4 14.5 11.7 9.3 8.4 6.8 7.8 3.8 9.5 17.5 13.2 6.5 9.8 12.2 5.0 14.4 8.9 19.3 10.4 8.0 8.8 10.4 6.4 14.2 5.2 7.8 6.0 5.4 8.2 5.8 5.3 6.1 2.0 6.3 7.7 5.8 19.7 5.8 3.6 6.3 6.4 2.6 35.0 37.4 42.4 41.5 33.9 33.9 37.7 36.5 40.2 32.3 35.8 41.5 34.2 9.6 20.8 41.1 23.6 5.2 14.2 6.6 8.6 71.7 8.7 13.1 39.3 20.0 14.1 12.9 66.7 7.9 24.6 9.3 9.8 11.2 0.7 21.8 23.2 20.7 13.1 36.4 36.8 7.5 3.2 25.3 8.6 25.5 20.3 19.4 15.4 7.8 9.0 47.1 34.0 4.9 12.2 17.1 7.2 2.8 31.1 14.7 1.8 15.0 24.1 30.8 33.0 20.6 58.9 12.1 7.7 34.3 15.9 9.1 12.9 10.7 28.0 258.1 52.6 32.7 24.1 10.7 10.6 6.6 6.1 10.8 21.8 26.2 7.4 9.6 EZH2 "ENX-1, EZH1, KMT6, KMT6A" ENSG00000106462 "Enhancer of zeste 2 polycomb repressive complex 2 subunit" Q15910 7 148807383-148884321 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Biological rhythms, Transcription, Transcription regulation" "Chromatin regulator, Methyltransferase, Repressor, Transferase" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 47.9;lymphoid tissue: 43.0;testis: 27.8" "Cell type enhanced" "Detected in many" "Early spermatids: 109.3;Spermatocytes: 142.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009589, HPA029131" Enhanced Supported Nucleoplasm NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "CAB009589: , HPA029131: AB_2672920" "unprognostic (2.42e-1)" "unprognostic (3.95e-3)" "unprognostic (1.57e-1)" "unprognostic (3.30e-3)" "unprognostic (1.33e-1)" "unprognostic (3.85e-3)" "prognostic unfavorable (2.11e-6)" "unprognostic (2.21e-2)" "prognostic unfavorable (1.96e-4)" "unprognostic (2.32e-3)" "unprognostic (1.58e-3)" "unprognostic (1.69e-3)" "prognostic unfavorable (8.18e-12)" "prognostic favorable (6.97e-4)" "unprognostic (1.83e-1)" "unprognostic (2.12e-1)" "unprognostic (6.67e-2)" 1.5 1.5 1.1 10.1 1.1 47.9 2.7 2.0 1.3 2.7 1.5 7.0 6.4 2.0 1.2 10.8 1.1 1.9 1.2 1.1 1.1 2.1 3.3 2.3 22.1 1.2 1.2 1.6 3.7 1.3 0.5 4.8 1.2 1.3 8.2 3.3 2.8 0.2 2.9 10.7 6.9 2.8 1.0 5.6 4.0 27.8 1.5 43.0 1.3 1.9 21.1 3.5 3.8 1.2 65.6 30.1 99.7 66.9 3.1 5.1 54.6 49.7 19.9 39.9 40.2 45.6 73.2 114.3 23.5 18.7 36.3 39.0 52.1 17.1 50.6 164.9 51.8 48.9 38.4 35.5 8.0 110.1 38.5 4.3 9.6 29.9 15.9 12.1 24.0 108.9 105.9 73.6 36.2 74.0 215.7 91.7 79.6 57.0 39.9 131.3 56.0 70.9 18.6 31.0 95.1 60.3 62.3 46.8 16.5 25.3 34.3 46.7 14.8 42.4 19.8 85.2 90.4 65.7 76.6 115.3 38.6 74.2 84.9 0.4 1.7 1.1 1.2 1.2 0.9 1.1 2.6 2.2 3.8 0.6 1.4 0.9 0.1 7.2 3.6 0.8 8.3 1.2 1.1 1.1 2.0 1.3 1.1 1.1 1.2 1.2 1.2 1.0 1.5 1.2 14.4 0.0 6.7 1.3 14.5 26.5 6.7 6.3 10.2 6.0 15.1 12.2 6.1 2.8 7.1 7.3 35.5 28.8 35.9 14.7 3.9 9.5 109.3 16.3 17.0 9.4 9.0 57.0 6.2 8.5 32.2 9.9 15.8 24.2 21.6 45.9 3.3 2.2 11.9 15.2 9.2 20.5 6.1 9.0 33.6 27.7 3.1 19.1 14.2 14.0 14.9 2.6 12.3 16.6 7.0 12.4 10.5 0.7 37.4 4.8 6.8 1.2 9.7 21.3 6.6 13.8 24.1 142.2 58.2 35.8 29.0 30.5 25.7 4.7 22.1 5.9 F13A1 F13A ENSG00000124491 "Coagulation factor XIII A chain" P00488 6 6144084-6321013 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Blood coagulation, Hemostasis" "Acyltransferase, Transferase" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adipose tissue: 232.8;placenta: 489.2" "Cell type enhanced" "Detected in many" "Hofbauer cells: 863.3;Langerhans cells: 205.1;Macrophages: 232.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "classical monocyte: 141.1;myeloid DC: 179.6" "Group enriched" "Detected in many" 184 "dendritic cells: 179.6;granulocytes: 50.2;monocytes: 141.1" "Cell line enhanced" "Detected in some" "AF22: 24.0;LHCN-M2: 8.9;RH-30: 43.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in some" "HPA001804, CAB002155" Enhanced "Secreted to blood" NA NA 1400000000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 28: Placenta - Pregnancy" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 4: Macrophages - Innate immune response" "CAB002155: AB_564077, HPA001804: AB_1078792" "unprognostic (4.44e-1)" "unprognostic (5.90e-2)" "unprognostic (2.65e-2)" "unprognostic (3.93e-2)" "unprognostic (5.02e-2)" "unprognostic (3.75e-2)" "unprognostic (5.27e-2)" "unprognostic (1.96e-1)" "unprognostic (2.68e-2)" "unprognostic (6.84e-3)" "unprognostic (4.96e-2)" "unprognostic (1.97e-1)" "prognostic unfavorable (6.61e-6)" "unprognostic (2.79e-2)" "unprognostic (1.52e-1)" "unprognostic (1.57e-1)" "unprognostic (2.54e-3)" 232.8 57.9 2.6 52.3 4.2 16.1 46.9 1.3 13.0 50.4 28.5 45.9 9.7 18.5 5.6 51.2 29.1 52.7 39.2 2.1 3.6 21.0 3.0 38.7 30.0 8.3 4.6 10.7 10.0 13.3 8.1 489.2 6.9 8.8 63.9 21.6 18.8 13.4 10.3 22.7 22.0 89.6 2.6 8.8 25.4 17.8 3.7 20.9 17.1 32.8 12.5 144.5 12.1 4.0 0.0 0.1 24.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 2.3 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 8.9 0.0 0.1 0.2 0.0 0.0 0.0 0.0 43.8 0.8 0.0 0.0 0.3 0.3 0.1 0.0 0.0 0.1 0.0 4.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 50.2 141.1 1.4 0.5 25.4 0.6 0.4 0.3 0.4 179.6 0.4 0.4 0.2 32.9 0.3 0.7 12.5 0.3 364.9 2.6 4.2 1.3 13.0 2.1 3.6 8.3 4.6 6.9 2.6 3.7 4.0 2.0 0.0 1.9 0.3 1.8 18.7 0.0 0.0 0.6 0.1 0.3 0.4 10.6 5.7 0.0 0.0 0.0 5.0 4.5 0.0 0.0 0.0 5.1 0.6 10.6 3.8 0.0 1.3 3.9 0.0 5.6 13.7 0.0 0.4 1.3 0.0 2.9 0.9 863.3 0.0 1.4 0.0 0.0 92.4 205.1 5.8 4.4 232.0 19.6 64.6 53.1 0.9 6.2 0.5 0.7 0.1 0.0 0.7 1.2 0.0 0.0 11.0 2.2 6.5 59.2 2.5 3.3 1.6 0.9 1.2 15.2 10.1 2.6 0.4 0.0 0.1 FAM20C "DKFZp547D065, DMP4, G-CK, IMAGE:4942737" ENSG00000177706 "FAM20C golgi associated secretory pathway kinase" Q8IXL6 7 192571-260772 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins" Biomineralization "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Collecting duct cells: 55.2;Hepatocytes: 94.0;Hofbauer cells: 54.9;Peritubular cells: 56.4;Proximal tubular cells: 48.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HSkMC: 55.3;hTERT-RPE1: 39.9;U-87 MG: 36.0;WM-115: 30.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019823 Approved "Nucleoplasm,Golgi apparatus" "Secreted in other tissues" NA NA 240000000 "Cluster 18: Non-specific - Mitochondria" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 4: Macrophages - Innate immune response" "Golgi apparatus" Nucleoplasm "HPA019823: AB_1848389" "unprognostic (1.94e-1)" "prognostic unfavorable (8.89e-4)" "unprognostic (3.15e-2)" "unprognostic (1.03e-2)" "unprognostic (3.33e-3)" "unprognostic (2.47e-2)" "unprognostic (7.86e-2)" "unprognostic (2.45e-3)" "unprognostic (3.35e-2)" "prognostic unfavorable (9.40e-6)" "unprognostic (1.97e-3)" "unprognostic (2.49e-1)" "unprognostic (3.08e-3)" "unprognostic (1.94e-2)" "unprognostic (3.92e-2)" "unprognostic (2.16e-2)" "unprognostic (3.83e-3)" 32.5 14.8 7.0 7.3 5.7 1.5 32.8 5.0 7.0 19.4 0.8 44.3 4.5 19.4 2.1 14.3 20.2 5.9 30.2 4.3 5.0 34.9 56.5 27.9 1.1 12.5 9.7 20.3 13.4 1.6 18.3 2.6 6.7 29.9 1.4 1.1 20.3 3.6 30.7 14.7 23.3 6.8 6.4 8.9 38.9 7.8 12.6 0.6 19.6 6.3 0.6 36.8 15.1 6.2 19.6 6.4 0.3 10.3 11.8 20.3 0.0 17.4 23.2 7.9 5.9 0.9 10.1 0.0 9.3 21.8 10.4 14.9 1.1 0.6 1.6 4.5 0.6 0.0 3.1 3.4 8.8 0.0 1.0 55.3 1.6 0.3 0.7 39.9 5.0 0.0 0.0 0.0 1.8 1.9 0.0 0.7 8.9 0.1 0.3 2.3 0.5 0.0 4.9 0.0 4.4 0.2 17.2 0.0 2.3 1.1 9.7 6.5 14.6 10.3 5.3 7.7 5.3 0.0 0.0 0.0 36.0 1.0 30.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.0 5.7 5.0 7.0 4.3 5.0 12.5 9.7 6.7 6.4 12.6 6.2 5.0 6.4 5.1 11.8 1.2 10.1 2.3 4.5 1.8 26.9 27.6 18.7 9.9 21.5 1.0 55.2 0.0 0.5 4.6 3.4 5.9 1.8 0.0 4.1 19.0 4.5 11.9 0.4 7.4 4.8 0.5 22.6 13.7 9.5 3.8 3.1 9.3 94.0 54.9 1.7 17.0 5.3 2.0 24.4 9.8 2.6 16.1 34.5 1.8 5.6 10.8 17.1 0.0 8.5 15.3 6.3 3.7 56.4 0.1 6.6 33.7 48.7 3.4 9.0 13.1 8.7 17.3 0.3 1.0 3.5 8.1 0.5 0.9 0.6 9.0 1.9 FANCL "FAAP43, FLJ10335, PHF9, Pog" ENSG00000115392 "FA complementation group L" Q9NW38 2 58159243-58241372 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Fanconi anemia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocyte precursor cells: 81.4;Oligodendrocytes: 188.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033842, HPA036685, HPA036686" Supported Approved "Nuclear bodies,Vesicles" NA Yes "Cluster 19: B-cells - Humoral immune response" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Nuclear bodies" Vesicles "CAB033842: AB_1122766, HPA036685: AB_10672474, HPA036686: AB_10670844" "unprognostic (3.02e-1)" "unprognostic (5.52e-2)" "unprognostic (2.19e-1)" "unprognostic (2.02e-3)" "unprognostic (6.24e-2)" "unprognostic (2.92e-2)" "prognostic unfavorable (2.81e-7)" "unprognostic (4.71e-2)" "unprognostic (2.63e-2)" "unprognostic (1.31e-2)" "unprognostic (3.50e-1)" "unprognostic (1.17e-2)" "prognostic unfavorable (1.12e-7)" "unprognostic (1.50e-1)" "unprognostic (1.39e-1)" "unprognostic (9.08e-3)" "prognostic favorable (7.80e-5)" 8.5 35.3 39.4 11.0 49.5 15.1 19.5 35.3 39.4 18.6 27.2 12.1 11.5 19.9 18.4 11.5 13.9 12.0 13.0 34.1 45.1 12.2 21.7 9.6 14.8 51.6 40.3 24.8 14.5 14.0 44.3 12.5 55.4 14.7 14.8 24.6 18.7 10.7 9.1 17.9 12.8 13.5 40.9 16.8 13.1 19.1 41.2 13.2 17.1 9.1 12.6 11.7 14.6 68.6 48.6 35.0 69.4 34.0 11.9 15.1 36.9 34.8 21.5 33.8 43.5 30.9 59.4 33.4 43.8 11.4 46.3 27.5 39.0 26.4 56.0 78.8 61.7 54.8 49.5 42.1 13.0 53.3 29.0 11.8 12.4 24.8 9.7 29.9 27.0 23.5 51.9 29.6 23.2 24.6 18.9 65.8 75.2 77.4 7.2 35.2 52.5 26.1 29.9 47.2 78.1 39.3 49.5 20.2 33.8 37.0 18.7 35.4 15.9 30.0 45.0 22.3 39.0 30.4 20.6 19.7 63.7 35.7 46.6 3.2 3.0 4.9 3.7 5.6 3.0 9.1 3.2 4.2 5.9 9.3 1.0 2.3 0.8 7.6 4.3 5.3 4.8 2.2 39.4 49.5 35.3 39.4 34.1 45.1 51.6 40.3 55.4 40.9 41.2 68.6 16.7 19.2 20.0 18.6 9.4 10.3 13.9 26.1 11.4 16.6 12.5 15.4 16.4 8.6 16.1 9.2 4.2 29.1 4.8 7.2 11.7 9.7 2.5 11.1 15.8 14.8 9.0 14.5 45.0 4.2 14.0 12.2 15.3 6.2 10.8 25.8 13.2 12.5 10.9 8.4 38.4 15.0 30.5 6.3 4.6 3.6 10.8 7.0 26.6 34.7 6.8 22.8 3.1 81.4 188.9 4.6 13.3 14.3 9.7 6.2 21.7 5.7 23.2 18.7 13.1 10.8 12.4 52.6 37.9 9.5 6.8 7.4 5.6 13.2 16.0 9.3 FASN "FAS, SDR27X1" ENSG00000169710 "Fatty acid synthase" P49327 17 82078338-82098294 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" "Hydrolase, Lyase, Multifunctional enzyme, Oxidoreductase, Transferase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 372.8;breast: 271.6" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 126.0;Breast glandular cells: 442.9;Breast myoepithelial cells: 165.4;Hepatocytes: 244.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in all" "SK-BR-3: 1109.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005192, HPA006461, CAB015417, HPA056108" Enhanced Enhanced "Plasma membrane,Cytosol" No No 3400000 "Cluster 57: Non-specific - Angiogenesis" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 30: Mammary glandular cells - Lactation" "Plasma membrane, Cytosol" "CAB005192: AB_2101095, CAB015417: AB_2231427, HPA006461: AB_1848437, HPA056108: AB_2683039" "unprognostic (3.35e-2)" "prognostic unfavorable (1.42e-5)" "unprognostic (9.69e-3)" "unprognostic (4.09e-2)" "unprognostic (3.46e-3)" "unprognostic (1.55e-2)" "unprognostic (3.09e-2)" "unprognostic (4.74e-3)" "unprognostic (3.15e-1)" "unprognostic (3.15e-1)" "unprognostic (2.87e-3)" "unprognostic (1.05e-1)" "prognostic unfavorable (7.16e-5)" "unprognostic (4.50e-2)" "unprognostic (9.62e-2)" "unprognostic (1.35e-2)" "unprognostic (7.03e-3)" 372.8 30.9 25.0 14.9 44.2 18.7 271.6 67.3 49.9 31.7 0.0 25.5 11.5 18.0 6.2 63.6 15.2 6.6 21.9 39.9 15.0 11.8 191.4 54.1 7.2 84.4 75.7 16.3 18.6 8.5 72.4 12.1 101.7 69.0 3.0 4.3 38.3 14.3 27.9 89.4 28.8 5.3 12.5 8.8 63.6 11.9 33.7 9.6 21.2 2.3 3.0 27.0 31.8 60.8 179.1 182.0 81.7 56.7 130.1 87.2 176.9 34.3 43.3 35.5 64.6 190.6 116.7 58.8 29.2 26.3 99.5 144.0 79.2 157.8 6.5 30.0 358.0 123.9 140.0 257.2 36.8 67.5 19.2 84.2 40.4 90.8 21.0 12.1 40.1 54.8 193.2 50.7 12.6 304.1 78.9 105.5 161.1 28.1 107.1 64.1 47.8 116.5 40.3 220.7 205.0 117.0 50.6 1109.2 93.6 29.5 199.4 123.4 71.1 52.3 107.0 45.2 88.4 68.5 17.1 60.6 31.2 71.1 79.5 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.2 0.2 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.1 25.0 44.2 67.3 49.9 39.9 15.0 84.4 75.7 101.7 12.5 33.7 60.8 9.6 25.6 126.0 28.4 7.4 7.8 12.7 33.2 8.0 28.7 442.9 165.4 5.9 21.5 28.4 11.0 6.2 32.0 12.8 35.7 3.9 19.2 1.5 19.6 19.8 10.8 18.1 20.6 11.9 29.2 77.7 13.4 33.6 17.1 12.7 29.9 10.8 244.1 13.9 30.3 12.5 22.3 22.4 9.8 6.2 3.4 16.4 7.0 17.8 4.7 6.2 14.1 8.2 11.6 17.6 19.1 23.6 11.3 9.7 60.4 6.5 5.9 23.7 13.1 0.0 9.0 14.9 1.8 11.7 34.1 13.8 29.6 10.6 27.9 27.4 19.6 FASTK FAST ENSG00000164896 "Fas activated serine/threonine kinase" Q14296 7 151076593-151080866 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Apoptosis "Kinase, RNA-binding, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031621, CAB032539" Approved Supported "Nuclear speckles,Mitochondria" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Mitochondria" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "Nuclear speckles" "CAB032539: AB_2101115, HPA031621: AB_10611966" "unprognostic (7.67e-2)" "unprognostic (6.41e-3)" "prognostic unfavorable (4.73e-4)" "unprognostic (2.60e-1)" "unprognostic (1.75e-3)" "unprognostic (2.03e-3)" "unprognostic (1.14e-3)" "unprognostic (1.01e-1)" "unprognostic (1.24e-1)" "unprognostic (4.66e-2)" "prognostic favorable (3.99e-4)" "unprognostic (3.49e-2)" "unprognostic (2.79e-2)" "unprognostic (4.12e-2)" "unprognostic (1.05e-1)" "unprognostic (1.09e-1)" "unprognostic (8.17e-2)" 23.4 36.5 35.5 13.4 33.8 8.2 21.7 32.3 50.6 23.5 30.1 31.5 26.2 23.3 11.9 39.5 21.1 14.5 66.9 34.8 32.9 34.9 58.0 18.8 14.4 34.2 33.9 24.6 28.1 31.0 41.2 9.4 34.5 34.1 11.8 7.9 27.8 18.8 122.6 28.2 25.0 11.8 33.1 24.8 29.0 21.8 35.7 14.7 26.9 95.3 10.5 26.7 25.1 34.3 39.3 45.0 13.9 34.9 50.4 22.4 22.8 29.9 40.1 25.3 29.7 31.5 34.9 9.2 41.0 40.9 46.9 24.1 13.5 36.4 6.1 26.9 23.8 11.4 12.7 27.8 62.7 9.0 25.2 29.8 51.8 29.4 21.5 20.9 30.0 22.4 17.0 20.2 29.2 80.4 20.4 23.5 24.6 47.8 50.8 13.2 17.4 30.4 34.2 27.8 16.4 18.2 40.3 62.5 43.0 11.5 34.4 31.2 24.0 32.7 7.5 31.7 28.0 50.5 33.0 6.5 66.2 19.0 39.8 18.0 31.5 30.1 22.3 32.5 23.4 19.5 23.4 23.4 28.4 21.6 25.5 21.9 6.8 20.4 32.5 38.2 28.3 21.9 35.5 33.8 32.3 50.6 34.8 32.9 34.2 33.9 34.5 33.1 35.7 34.3 21.2 0.0 7.0 17.9 34.3 24.6 37.8 68.8 23.3 42.9 31.7 26.9 18.9 30.0 43.6 25.8 25.0 49.2 38.2 59.2 86.1 49.4 10.0 22.5 21.3 22.9 44.9 28.2 12.7 47.6 26.8 33.8 54.6 24.8 38.8 38.6 23.6 37.1 43.3 37.0 13.6 54.9 59.0 26.3 22.5 20.2 36.4 25.8 94.3 7.5 35.3 54.7 44.3 9.5 10.7 38.6 40.0 34.3 46.1 27.7 86.6 66.3 24.9 51.1 13.1 33.7 35.0 58.5 70.7 36.0 25.3 60.5 34.8 50.1 61.2 35.0 FCSK "FLJ39408, FUK" ENSG00000157353 "Fucose kinase" Q8N0W3 16 70454595-70480274 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Transferase" "Congenital disorder of glycosylation, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in some" "Adipocytes: 2.7;Cardiomyocytes: 4.2;Cytotrophoblasts: 5.5;Extravillous trophoblasts: 3.0;Hofbauer cells: 5.0;Syncytiotrophoblasts: 5.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041971 Approved Approved Vesicles NA NA "Cluster 32: T-cells - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 6: T47d - Mammary gland" "Cluster 24: Non-specific - Transcription regulation" Vesicles "HPA041971: AB_10795648" "unprognostic (4.55e-1)" "unprognostic (3.21e-1)" "unprognostic (1.73e-2)" "unprognostic (3.95e-2)" "unprognostic (3.79e-2)" "unprognostic (2.64e-2)" "unprognostic (8.79e-3)" "unprognostic (1.26e-1)" "unprognostic (1.49e-1)" "unprognostic (1.57e-1)" "unprognostic (4.82e-3)" "unprognostic (4.85e-2)" "prognostic favorable (8.91e-4)" "unprognostic (2.49e-2)" "unprognostic (9.68e-2)" "unprognostic (8.89e-2)" "prognostic favorable (8.38e-4)" 3.9 7.2 5.4 5.4 7.1 5.0 4.9 8.2 7.7 5.6 7.5 7.5 10.1 4.9 2.4 5.6 5.5 3.8 4.3 5.3 5.0 8.9 8.2 4.8 5.4 6.4 4.6 6.6 8.3 9.1 9.8 3.6 5.7 6.3 3.9 2.9 5.9 4.4 5.5 7.2 7.4 3.1 4.5 6.4 6.6 4.5 5.7 3.8 7.9 2.3 2.8 4.8 4.8 11.1 3.4 4.6 2.5 5.8 1.5 1.8 10.0 1.8 2.8 2.2 3.0 4.2 10.0 2.3 8.8 1.7 0.7 4.8 1.8 4.7 1.6 4.4 6.5 2.9 8.9 4.5 3.7 3.8 2.3 3.0 5.4 2.1 4.4 3.3 4.3 4.6 5.9 2.6 1.8 10.3 4.6 9.2 1.6 5.5 2.7 7.0 0.6 10.4 5.9 5.5 4.0 5.3 10.1 3.7 5.3 1.9 14.8 7.5 5.0 1.8 2.4 4.0 2.2 9.5 5.1 4.8 3.3 3.8 4.2 0.2 1.9 0.8 1.9 1.0 1.6 0.8 1.9 1.9 1.1 1.5 2.6 1.2 1.6 1.2 1.2 1.3 1.4 1.2 5.4 7.1 8.2 7.7 5.3 5.0 6.4 4.6 5.7 4.5 5.7 11.1 2.7 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.2 0.0 0.0 0.0 0.0 5.5 1.1 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 3.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 5.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 5.2 0.2 0.0 0.0 0.0 FDFT1 SQS ENSG00000079459 "Farnesyl-diphosphate farnesyltransferase 1" P37268 8 11795573-11839304 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" "Multifunctional enzyme, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Basal respiratory cells: 479.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Group enriched" "Detected in all" 4 "Daudi: 133.1;RPMI-8226: 361.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008874 Approved Supported "Endoplasmic reticulum" NA NA "Cluster 37: B-cells - Transcription" "Cluster 72: Non-specific - Transcription" "Cluster 25: RPMI-8226 - Immune response" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Endoplasmic reticulum" "HPA008874: AB_1078844" "unprognostic (2.33e-1)" "unprognostic (2.60e-1)" "prognostic favorable (4.92e-5)" "unprognostic (1.29e-2)" "unprognostic (1.46e-2)" "unprognostic (1.71e-1)" "unprognostic (8.10e-2)" "unprognostic (1.01e-1)" "unprognostic (2.39e-1)" "unprognostic (2.45e-1)" "unprognostic (2.31e-3)" "unprognostic (2.57e-1)" "prognostic favorable (6.59e-9)" "unprognostic (2.28e-1)" "unprognostic (4.06e-2)" "unprognostic (3.86e-1)" "unprognostic (2.06e-1)" 69.1 126.7 8.2 6.7 14.9 15.0 69.5 13.1 11.6 93.3 7.4 113.4 6.7 80.2 2.9 165.7 59.4 3.2 62.9 10.0 11.7 71.3 118.3 88.0 6.0 29.9 14.1 66.9 58.6 2.0 51.2 4.2 23.1 64.5 5.8 5.4 141.7 3.1 160.3 129.0 92.2 4.9 15.4 50.4 113.2 118.7 15.3 3.2 45.9 6.9 4.5 70.4 107.8 31.9 19.1 8.1 28.8 19.4 3.8 5.7 10.9 19.2 10.6 7.4 8.6 8.1 14.1 133.1 3.9 3.2 34.6 17.8 10.6 24.7 8.2 13.1 17.2 9.6 11.1 21.7 7.4 5.5 13.0 11.2 6.0 13.2 4.7 5.3 2.1 24.5 12.1 60.0 4.6 11.1 16.7 12.9 27.1 9.0 5.3 14.9 11.3 361.0 11.9 61.5 9.6 11.2 4.3 11.2 35.9 12.3 11.6 6.8 11.3 5.1 21.6 3.1 5.8 17.0 30.2 26.3 7.5 18.7 19.7 52.1 19.5 25.5 23.1 23.6 20.7 60.5 25.3 24.5 29.1 45.6 25.7 23.3 22.3 26.7 15.1 27.9 45.7 43.9 8.2 14.9 13.1 11.6 10.0 11.7 29.9 14.1 23.1 15.4 15.3 31.9 31.1 54.5 164.1 67.6 78.0 52.5 94.0 479.6 87.6 17.7 79.6 49.8 78.5 101.5 325.8 79.1 14.6 266.2 49.4 134.8 88.0 165.6 294.4 55.0 20.9 45.2 79.1 113.2 29.3 284.4 153.3 37.1 64.2 68.1 57.0 86.2 22.1 221.8 94.1 11.8 25.6 117.4 284.8 41.9 32.2 228.8 77.0 54.3 101.4 38.4 97.1 61.9 55.6 30.2 95.6 163.6 108.4 53.4 50.0 101.3 87.0 74.9 142.6 21.0 52.6 13.8 74.4 215.5 76.1 112.5 88.8 175.0 55.7 131.4 100.4 167.2 FDPS ENSG00000160752 "Farnesyl diphosphate synthase" P14324 1 155308748-155320666 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Host-virus interaction, Isoprene biosynthesis, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" Transferase "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 355.7" "Cell type enhanced" "Detected in all" "Basal respiratory cells: 927.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HBEC3-KT: 1187.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA028200 Approved Approved Nucleoplasm,Cytosol NA NA 1500000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 37: Intestine - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Cytosol Nucleoplasm "HPA028200: AB_10612109" "unprognostic (1.23e-1)" "unprognostic (8.46e-3)" "unprognostic (2.47e-2)" "unprognostic (6.57e-2)" "unprognostic (4.58e-2)" "unprognostic (2.84e-2)" "prognostic unfavorable (7.35e-4)" "unprognostic (4.21e-2)" "unprognostic (6.78e-3)" "unprognostic (1.64e-3)" "unprognostic (7.19e-2)" "unprognostic (2.25e-2)" "unprognostic (1.11e-2)" "unprognostic (8.25e-2)" "unprognostic (2.07e-1)" "unprognostic (5.65e-2)" "unprognostic (8.44e-2)" 73.5 188.2 48.2 66.5 50.4 69.5 68.8 60.1 58.8 63.4 51.1 88.7 167.2 57.5 73.0 142.5 57.4 39.8 72.2 49.9 64.6 78.0 355.7 86.1 76.1 71.1 62.5 45.0 75.7 67.9 40.4 72.5 77.5 56.1 102.9 45.9 82.6 42.7 60.9 107.1 81.1 66.0 53.6 59.3 81.5 42.0 55.0 72.6 46.8 66.7 102.3 47.0 76.8 55.0 293.9 156.2 561.5 204.4 128.7 467.7 199.6 136.8 268.1 213.6 344.2 255.4 677.7 222.3 323.6 120.6 506.9 319.1 338.9 1187.5 198.9 122.4 242.5 129.4 260.1 311.5 210.8 212.1 142.0 335.5 184.6 339.6 168.8 96.4 377.6 322.3 235.1 579.9 225.3 315.1 273.6 205.0 338.9 216.4 225.5 231.6 243.2 620.0 567.7 193.0 217.4 185.6 140.7 253.0 243.0 317.3 182.6 567.6 277.1 118.4 144.3 74.3 254.9 244.3 202.3 401.1 115.3 221.7 191.1 90.6 85.5 124.1 89.2 92.9 79.7 102.8 77.8 91.1 95.6 95.1 69.9 87.1 38.9 115.2 70.0 76.2 113.7 134.7 48.2 50.4 60.1 58.8 49.9 64.6 71.1 62.5 77.5 53.6 55.0 55.0 154.2 73.7 181.6 38.5 68.4 36.8 83.3 927.7 42.1 69.4 84.6 56.9 1.8 97.2 431.5 53.3 62.6 207.8 74.9 343.0 137.0 180.9 216.6 56.7 38.2 161.9 71.4 133.4 30.8 329.9 198.7 59.8 52.0 77.8 62.8 116.6 168.1 361.9 112.0 55.5 28.1 135.7 299.1 54.8 44.4 67.9 60.9 52.8 96.0 15.0 144.7 81.1 87.6 22.6 39.7 256.7 324.3 70.3 91.3 206.1 194.1 145.0 129.6 90.8 72.3 47.0 177.5 42.0 14.2 49.7 59.8 143.5 68.3 230.6 165.4 148.2 FER "PPP1R74, TYK3" ENSG00000151422 "FER tyrosine kinase" P16591 5 108747841-109196841 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in all" 6 "Alveolar cells type 1: 80.1;Astrocytes: 207.3;Early spermatids: 158.1;Excitatory neurons: 266.3;granulocytes: 95.5;Inhibitory neurons: 313.8;Late spermatids: 182.4;Microglial cells: 227.7;Oligodendrocyte precursor cells: 284.0;Oligodendrocytes: 216.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in many" 5 "RPMI-8226: 91.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007641, CAB022464" Approved Supported Cytosol NA NA "Cluster 37: B-cells - Transcription" "Cluster 21: Non-specific - Transcription" "Cluster 25: RPMI-8226 - Immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol "CAB022464: , HPA007641: AB_1078845" "unprognostic (1.72e-1)" "unprognostic (1.66e-2)" "unprognostic (1.74e-1)" "unprognostic (2.46e-3)" "unprognostic (4.72e-2)" "unprognostic (5.65e-2)" "unprognostic (6.81e-2)" "unprognostic (7.39e-2)" "unprognostic (1.05e-1)" "unprognostic (8.36e-3)" "unprognostic (7.36e-2)" "unprognostic (8.05e-2)" "prognostic favorable (5.55e-4)" "unprognostic (3.83e-3)" "unprognostic (3.22e-1)" "unprognostic (1.03e-1)" "unprognostic (3.99e-3)" 4.2 3.7 3.4 3.0 3.2 1.6 3.6 2.8 3.4 3.8 0.6 3.9 1.7 3.7 2.9 4.2 3.0 3.3 3.0 3.1 3.9 3.5 2.3 3.7 1.4 3.6 3.7 4.6 1.9 9.4 2.5 4.2 3.8 3.0 2.4 5.7 2.5 3.9 1.3 4.5 2.0 4.9 4.1 2.7 2.2 6.7 3.1 2.8 6.4 2.0 2.0 3.5 3.2 5.0 9.8 3.4 11.0 18.0 6.6 10.1 7.2 11.4 11.0 6.5 7.6 19.0 5.5 15.3 6.9 13.8 8.4 6.3 6.2 14.4 14.7 6.5 8.4 9.8 14.5 7.0 4.4 5.6 8.2 6.2 7.9 15.8 17.5 6.4 9.8 14.6 12.9 11.1 8.4 2.7 4.4 1.7 1.6 0.9 7.0 3.3 10.7 91.7 6.4 3.3 3.8 5.6 18.6 1.0 11.4 7.0 4.4 2.4 14.7 12.5 10.2 6.5 9.0 9.4 14.9 5.9 7.4 1.9 6.0 8.9 3.7 4.6 1.2 2.5 2.1 10.3 0.7 1.4 2.3 3.4 1.2 1.5 0.3 1.1 2.0 4.5 1.7 0.9 3.4 3.2 2.8 3.4 3.1 3.9 3.6 3.7 3.8 4.1 3.1 5.0 23.8 80.1 28.3 207.3 9.5 29.2 15.8 9.5 25.6 17.6 6.6 8.5 21.9 10.0 21.8 14.7 18.8 3.9 7.5 4.9 1.9 13.6 158.1 13.1 17.2 19.7 8.4 10.7 266.3 6.0 10.7 31.4 16.8 12.6 95.5 21.8 18.9 2.3 8.2 18.5 313.8 4.5 8.2 9.5 13.4 182.4 19.3 14.1 14.2 227.7 12.0 10.5 4.1 284.0 216.0 9.1 4.7 17.7 13.7 12.1 1.7 6.9 27.9 16.3 6.6 30.7 23.8 7.7 11.5 13.2 17.6 3.1 10.4 10.2 4.1 6.9 FES FPS ENSG00000182511 "FES proto-oncogene, tyrosine kinase" P07332 15 90883695-90895776 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Proto-oncogene, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 83.4;lymphoid tissue: 110.9" "Cell type enhanced" "Detected in many" "Adipocytes: 46.8;Hofbauer cells: 48.7;Kupffer cells: 92.3;Macrophages: 51.9;monocytes: 57.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "eosinophil: 315.8" "Group enriched" "Detected in many" 4 "dendritic cells: 162.6;granulocytes: 315.8;monocytes: 151.7" "Cell line enhanced" "Detected in many" "HEL: 63.5;HL-60: 56.9;HMC-1: 116.6;NB-4: 76.1;THP-1: 110.8;U-937: 48.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA001376 Approved Approved Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 2: Immune cells - Immune response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 10: Non-specific - Unknown function" "Nucleoplasm, Cytosol" Vesicles "HPA001376: AB_1078847" "unprognostic (1.07e-2)" "unprognostic (2.54e-2)" "prognostic unfavorable (5.78e-4)" "unprognostic (2.31e-2)" "unprognostic (4.05e-3)" "unprognostic (7.33e-2)" "unprognostic (1.74e-1)" "unprognostic (2.22e-1)" "unprognostic (1.58e-3)" "unprognostic (1.35e-1)" "unprognostic (4.66e-2)" "unprognostic (5.15e-3)" "unprognostic (1.78e-3)" "unprognostic (2.53e-3)" "unprognostic (6.08e-2)" "unprognostic (1.18e-1)" "unprognostic (1.40e-1)" 30.8 8.0 9.4 20.2 8.8 83.4 21.3 9.6 10.8 18.1 9.6 12.5 5.8 15.7 2.4 5.9 19.0 14.0 19.6 8.3 8.7 18.9 25.2 30.9 13.8 11.1 9.2 13.5 7.8 2.3 5.6 16.3 10.1 17.9 4.6 1.5 58.3 8.0 6.1 8.0 12.5 10.7 10.4 110.9 9.6 4.5 10.9 4.2 16.0 7.0 5.7 15.1 13.5 9.8 0.4 0.8 0.8 10.3 3.1 8.8 17.9 2.9 0.1 5.1 2.9 2.6 0.1 6.8 0.5 6.0 0.2 1.5 1.7 0.3 1.6 3.3 1.1 63.5 0.0 11.9 6.8 56.9 116.6 8.8 0.1 7.6 0.0 0.0 31.2 9.4 1.8 0.2 0.0 21.3 1.8 76.1 3.2 2.5 0.0 8.6 0.1 0.1 0.0 0.2 0.4 0.1 0.0 2.8 2.3 2.9 0.1 110.8 24.9 0.2 10.4 0.2 0.2 0.1 8.0 2.5 0.3 48.0 2.4 64.4 151.7 315.8 0.5 88.6 0.4 5.2 0.3 0.4 162.6 4.1 0.2 0.3 100.5 51.4 39.8 65.0 0.2 81.5 9.4 8.8 9.6 10.8 8.3 8.7 11.1 9.2 10.1 10.4 10.9 9.8 46.8 3.2 5.8 3.6 5.0 3.8 5.4 0.5 0.6 0.2 4.1 3.8 3.4 8.6 0.5 1.8 0.0 5.3 25.6 0.6 3.9 7.3 1.7 2.0 4.2 29.1 3.0 8.0 2.8 4.3 4.2 9.0 2.0 4.2 29.2 10.7 20.0 15.0 48.7 0.0 0.2 2.0 2.0 92.3 27.9 8.4 9.0 51.9 7.2 5.6 57.8 2.5 26.8 2.0 0.3 2.1 2.0 10.1 4.0 3.1 0.7 1.5 0.2 1.9 13.1 4.6 12.9 4.4 15.9 1.0 2.8 4.5 6.7 3.3 3.7 5.2 FGFR1 "BFGFR, CD331, CEK, FLG, FLT2, H2, H3, H4, H5, KAL2, N-SAM" ENSG00000077782 "Fibroblast growth factor receptor 1" P11362 8 38400215-38468834 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins, Transporters" "Transcription, Transcription regulation" "Heparin-binding, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Craniosynostosis, Disease variant, Dwarfism, FDA approved drug targets, Holoprosencephaly, Hypogonadotropic hypogonadism, Kallmann syndrome, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Fibroblasts: 176.7;Leydig cells: 192.0;Oligodendrocyte precursor cells: 166.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "AN3-CA: 508.7;BJ hTERT+: 278.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033614, HPA056402" Approved NA NA 78000000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 89: Fibroblasts - ECM organization" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 50: Fibroblasts - ECM organization" "CAB033614: AB_783377, HPA056402: AB_2683118" "unprognostic (9.53e-2)" "unprognostic (7.33e-2)" "unprognostic (2.44e-1)" "unprognostic (1.35e-2)" "unprognostic (4.23e-3)" "unprognostic (7.02e-2)" "unprognostic (6.59e-2)" "unprognostic (2.77e-1)" "unprognostic (1.81e-1)" "unprognostic (3.99e-2)" "unprognostic (7.97e-3)" "unprognostic (4.59e-2)" "unprognostic (7.69e-2)" "unprognostic (6.87e-3)" "unprognostic (5.60e-2)" "unprognostic (4.59e-3)" "unprognostic (1.05e-3)" 95.1 12.8 27.5 15.9 24.6 14.1 87.1 48.8 22.4 79.8 37.2 97.2 8.8 74.2 15.8 35.8 85.9 57.1 89.9 30.9 28.8 40.1 9.1 55.7 16.6 35.9 37.3 108.2 98.6 20.4 57.1 51.3 63.7 60.5 17.9 15.8 31.4 53.6 24.8 35.6 41.7 57.1 30.3 9.9 40.4 20.4 33.4 17.1 33.7 23.3 16.1 79.3 63.9 29.6 12.9 42.0 198.0 508.7 120.1 91.2 142.9 136.7 278.8 90.0 95.8 27.3 6.5 1.8 38.3 127.7 103.9 0.2 90.0 6.8 104.3 39.2 24.1 0.0 7.7 27.8 69.7 31.1 0.6 80.5 0.7 70.9 13.3 45.6 86.9 6.0 11.9 0.4 40.5 12.5 91.5 9.2 145.9 1.6 21.6 86.3 21.1 0.4 35.6 0.3 7.9 19.4 23.4 1.0 5.1 93.4 9.3 5.4 51.4 49.2 28.9 149.6 29.7 2.4 4.1 0.5 60.3 1.7 27.1 0.2 0.3 0.1 1.7 0.1 1.1 0.3 0.7 1.2 0.0 0.6 0.5 1.5 0.6 0.4 0.2 0.2 1.0 0.1 27.5 24.6 48.8 22.4 30.9 28.8 35.9 37.3 63.7 30.3 33.4 29.6 101.0 3.2 15.8 55.8 1.8 31.5 95.9 1.1 37.0 4.4 28.7 77.7 52.5 24.3 5.1 9.2 4.2 8.3 6.3 0.4 0.0 27.3 15.3 48.2 40.6 75.5 25.0 3.6 25.4 65.2 80.5 176.7 3.1 75.3 8.2 40.4 47.5 0.8 25.3 21.9 21.1 0.6 4.1 5.6 75.2 15.0 192.0 11.7 33.8 19.7 1.7 88.1 6.2 166.4 14.2 21.6 0.3 99.6 6.4 94.7 0.1 7.9 1.0 3.3 13.1 118.9 59.9 1.6 14.1 4.8 19.7 10.4 14.1 2.1 0.7 11.7 FGFR2 "BEK, CD332, CEK3, CFD1, ECT1, JWS, K-SAM, KGFR, TK14, TK25" ENSG00000066468 "Fibroblast growth factor receptor 2" P21802 10 121478332-121598458 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" Apoptosis "Heparin-binding, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Craniosynostosis, Disease variant, Ectodermal dysplasia, FDA approved drug targets, Lacrimo-auriculo-dento-digital syndrome, Mental retardation, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 273.8;choroid plexus: 198.1" "Group enriched" "Detected in many" 5 "Astrocytes: 228.2;Cholangiocytes: 213.1;Oligodendrocytes: 562.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 24 "basophil: 13.2;eosinophil: 3.8" "Lineage enriched" "Detected in single" 58 "granulocytes: 13.2" "Cell line enhanced" "Detected in many" "AN3-CA: 189.0;BEWO: 60.9;CACO-2: 49.6;HaCaT: 55.6;HAP1: 63.7;NTERA-2: 57.8;T-47d: 49.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010886, HPA035305" Uncertain Supported "Nucleoplasm,Vesicles,Cell Junctions" "Secreted - unknown location" NA NA 1200000 "Cluster 34: Basophils - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Cell Junctions" "Nucleoplasm, Vesicles" "CAB010886: AB_259379, HPA035305: AB_10672862" "unprognostic (5.53e-2)" "prognostic favorable (8.79e-4)" "unprognostic (1.08e-1)" "unprognostic (5.23e-2)" "unprognostic (1.73e-1)" "prognostic favorable (9.32e-4)" "unprognostic (1.53e-1)" "unprognostic (4.96e-3)" "unprognostic (1.74e-1)" "unprognostic (1.56e-1)" "unprognostic (1.07e-1)" "unprognostic (3.74e-2)" "unprognostic (1.01e-1)" "unprognostic (6.11e-2)" "unprognostic (2.54e-1)" "unprognostic (6.93e-2)" "unprognostic (2.25e-1)" 5.7 21.3 103.9 8.2 186.8 0.3 22.9 178.9 198.9 19.7 198.1 44.8 10.4 54.6 15.3 25.2 29.6 31.3 5.6 109.9 124.7 26.3 41.0 30.9 2.9 250.9 185.9 18.0 31.0 61.0 6.8 15.7 220.5 27.4 21.2 1.2 59.1 54.6 0.5 109.3 12.2 43.6 165.5 0.8 22.5 7.6 148.0 10.1 54.6 0.2 9.1 16.6 27.4 273.8 7.2 0.4 30.2 189.0 0.1 0.0 60.9 0.4 0.0 0.0 0.0 49.6 1.1 0.1 12.5 2.8 0.1 55.6 63.7 13.0 0.0 0.1 12.7 0.0 0.2 1.2 1.5 0.2 11.7 0.1 26.2 0.0 0.6 0.0 0.0 0.3 0.2 0.2 0.0 11.7 0.2 0.1 57.8 8.7 0.0 0.1 0.0 7.5 18.0 15.8 0.5 0.5 0.4 33.4 0.0 36.6 49.3 0.0 0.1 0.3 8.5 0.2 0.7 0.1 0.1 0.0 0.3 0.0 0.5 13.2 0.0 3.8 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 103.9 186.8 178.9 198.9 109.9 124.7 250.9 185.9 220.5 165.5 148.0 273.8 1.4 19.2 36.0 228.2 0.6 40.1 34.3 18.4 58.6 0.2 8.7 25.4 9.1 213.1 38.4 36.8 0.0 16.5 0.3 7.3 0.0 7.4 4.1 28.1 4.4 1.0 2.4 2.7 14.8 0.2 3.0 9.0 13.3 53.1 0.0 0.1 1.8 5.0 2.3 0.0 31.2 40.8 10.2 0.6 4.4 9.6 1.2 1.1 5.4 10.3 0.6 2.0 1.0 6.0 562.5 0.7 3.0 6.0 0.1 15.0 1.8 13.6 15.3 0.2 0.0 1.6 2.6 0.7 9.9 18.7 27.7 4.0 1.5 0.4 3.8 31.4 FGFR3 "ACH, CD333, CEK2, JTK4" ENSG00000068078 "Fibroblast growth factor receptor 3" P22607 4 1793293-1808872 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" Apoptosis "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Craniosynostosis, Deafness, Disease variant, Dwarfism, Ectodermal dysplasia, FDA approved drug targets, Lacrimo-auriculo-dento-digital syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 148.3;esophagus: 139.7;skin 1: 271.5" "Cell type enhanced" "Detected in many" "Astrocytes: 410.4;Basal keratinocytes: 103.8;Cholangiocytes: 91.5;Suprabasal keratinocytes: 88.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "CACO-2: 48.2;HaCaT: 34.9;Hep G2: 80.6;NTERA-2: 36.1;RT4: 64.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004231, HPA067204" Enhanced Supported "Endoplasmic reticulum" "Secreted - unknown location" NA NA 2500000 "Cluster 27: Brain & Skin - Unknown function" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 64: Astrocytes - Nervous system maintenance" "Endoplasmic reticulum" "CAB004231: AB_627596, HPA067204: AB_2685804" "unprognostic (1.34e-1)" "unprognostic (5.29e-3)" "unprognostic (1.49e-1)" "prognostic unfavorable (3.77e-4)" "unprognostic (5.90e-2)" "unprognostic (1.24e-3)" "unprognostic (7.22e-2)" "unprognostic (2.54e-1)" "unprognostic (1.99e-1)" "unprognostic (2.17e-1)" "unprognostic (1.38e-1)" "unprognostic (2.88e-2)" "unprognostic (1.30e-1)" "unprognostic (9.11e-3)" "unprognostic (1.98e-1)" "unprognostic (4.74e-2)" "unprognostic (1.97e-1)" 1.6 1.6 118.0 1.5 140.6 1.4 5.5 115.6 104.0 23.7 37.4 12.2 19.5 1.5 2.8 139.7 2.2 7.9 4.8 100.8 107.6 39.3 40.7 7.4 0.4 144.7 129.2 0.5 76.4 0.2 16.1 9.3 109.8 13.8 5.2 0.2 20.2 15.0 1.3 271.5 14.7 0.4 108.9 4.0 7.8 17.6 148.3 1.7 1.5 0.9 11.1 23.1 60.9 81.2 0.0 3.8 19.5 5.6 0.0 0.3 22.1 2.4 0.3 0.8 0.4 48.2 1.0 0.0 17.8 0.7 0.7 34.9 5.5 0.3 0.3 0.2 19.3 14.2 3.9 80.6 0.1 0.0 0.6 0.0 10.9 0.2 0.1 0.1 0.1 2.3 16.7 0.1 0.0 23.9 0.8 0.5 36.1 19.5 0.1 1.2 1.0 0.3 2.8 64.1 5.7 1.6 1.9 4.0 0.0 22.2 20.4 2.5 1.0 0.0 2.1 0.5 1.6 0.1 0.0 0.0 0.2 1.7 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 118.0 140.6 115.6 104.0 100.8 107.6 144.7 129.2 109.8 108.9 148.3 81.2 2.2 0.0 32.5 410.4 1.1 103.8 4.1 29.8 23.9 0.0 4.8 1.5 3.1 91.5 37.6 14.7 0.0 0.5 1.6 36.1 0.0 5.0 7.9 3.0 1.7 3.4 4.2 0.0 0.5 0.7 12.0 3.2 3.6 4.0 0.0 0.1 16.1 30.4 0.6 0.0 1.3 20.7 4.1 1.2 6.5 1.3 0.6 0.6 12.4 14.0 0.6 0.1 0.0 34.2 2.2 0.4 18.0 0.4 0.0 4.2 21.2 9.9 9.8 0.6 0.0 0.7 2.9 0.4 25.9 55.0 88.7 0.8 0.7 0.1 17.0 12.8 FGFR4 "CD334, JTK2" ENSG00000160867 "Fibroblast growth factor receptor 4" P22455 5 177086905-177098144 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins, Transporters" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 82.5;lung: 65.4" "Cell type enhanced" "Detected in many" "Cholangiocytes: 78.6;Hepatocytes: 31.2;Skeletal myocytes: 141.2;Theca cells: 36.7;Undifferentiated cells: 38.6" "Cancer enhanced" "Detected in many" "liver cancer: 42.0" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in many" 4 "CACO-2: 173.9;Hep G2: 176.4;RH-30: 274.3" "Not detected" "Not detected" "Low region specificity" "Detected in many" "CAB005196, HPA027273, HPA027369, HPA028251" Approved "Intracellular and membrane" NA NA 7400000 "Cluster 18: Non-specific - Mitochondria" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 50: Fibroblasts - ECM organization" "CAB005196: AB_631512, HPA027273: AB_10600212, HPA027369: AB_10599427, HPA028251: AB_10601221" "unprognostic (1.96e-1)" "unprognostic (2.10e-2)" "unprognostic (1.12e-1)" "unprognostic (9.06e-3)" "unprognostic (2.87e-1)" "unprognostic (1.95e-2)" "unprognostic (7.85e-3)" "unprognostic (9.19e-2)" "unprognostic (4.25e-1)" "unprognostic (4.46e-2)" "unprognostic (1.16e-1)" "unprognostic (3.48e-2)" "unprognostic (1.78e-1)" "unprognostic (1.71e-3)" "unprognostic (2.41e-1)" "unprognostic (5.75e-2)" "unprognostic (4.68e-2)" 1.2 14.0 1.1 4.1 1.1 0.5 4.5 2.7 2.1 3.0 1.2 18.0 21.3 2.4 0.2 3.2 4.2 10.2 2.2 1.4 1.0 40.2 82.5 65.4 0.8 0.7 0.8 27.5 29.5 0.2 2.0 2.1 0.9 5.2 6.0 1.5 1.1 0.7 6.6 1.7 20.0 1.1 0.7 22.7 8.8 5.9 1.1 0.2 0.9 1.9 0.2 6.4 3.2 1.3 3.2 48.8 1.0 11.7 0.1 0.1 24.5 0.2 0.1 0.2 0.3 173.9 6.5 5.3 23.0 0.1 2.4 2.8 9.5 1.8 0.1 3.2 13.8 0.5 2.8 176.4 5.2 0.6 4.7 1.1 0.2 8.4 0.2 0.3 0.2 3.5 18.1 0.7 3.9 40.3 0.1 3.6 29.2 30.9 4.5 8.2 274.3 30.9 22.9 0.4 1.8 2.9 1.8 12.4 5.9 5.9 11.7 2.5 1.1 0.0 23.4 0.3 0.7 1.6 1.9 3.7 0.1 1.1 2.0 0.2 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 1.1 1.1 2.7 2.1 1.4 1.0 0.7 0.8 0.9 0.7 1.1 1.3 0.3 0.0 0.0 0.3 0.3 0.6 0.7 0.4 0.0 0.9 2.9 2.0 0.9 78.6 0.1 3.7 0.0 1.3 0.1 12.9 3.9 10.9 0.1 1.6 0.3 0.7 4.2 0.0 0.5 4.9 3.8 9.6 9.7 2.9 0.0 0.7 3.9 31.2 0.3 0.0 0.5 10.1 0.0 0.9 0.5 0.0 0.6 0.7 0.0 1.9 0.6 0.6 0.0 0.5 0.1 3.0 4.4 1.5 0.1 1.7 15.9 21.6 0.1 0.4 19.7 141.2 0.7 3.0 9.9 0.8 0.4 8.8 0.4 36.7 38.6 0.5 FGR "c-fgr, p55c-fgr, SRC2" ENSG00000000938 "FGR proto-oncogene, Src family tyrosine kinase" P09769 1 27612064-27635185 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Immunity, Innate immunity" "Kinase, Transferase, Tyrosine-protein kinase" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "bone marrow: 207.8;lung: 86.5;lymphoid tissue: 141.1" "Cell type enhanced" "Detected in many" "Kupffer cells: 182.2;Langerhans cells: 63.8;Macrophages: 155.9;monocytes: 159.7;NK-cells: 259.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Group enriched" "Detected in some" 4 "Daudi: 86.0;U-266/70: 153.1" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA002024 Enhanced Approved "Plasma membrane,Aggresome" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 29: U-266 - Adaptive immune response" "Cluster 19: Monocytes & Neutrophils - Innate immune response" "Plasma membrane" Aggresome "HPA002024: AB_1078503" "unprognostic (2.66e-2)" "unprognostic (1.51e-2)" "unprognostic (6.32e-2)" "unprognostic (9.74e-3)" "unprognostic (6.66e-3)" "unprognostic (6.71e-2)" "unprognostic (5.77e-2)" "unprognostic (1.25e-1)" "unprognostic (1.81e-2)" "unprognostic (7.45e-2)" "unprognostic (2.79e-2)" "unprognostic (1.10e-1)" "unprognostic (1.94e-2)" "unprognostic (6.26e-2)" "unprognostic (3.93e-2)" "unprognostic (2.30e-1)" "unprognostic (8.12e-3)" 25.0 6.8 12.8 62.2 11.9 207.8 16.0 11.9 19.1 7.6 11.5 6.0 3.9 8.1 1.7 5.2 15.6 12.7 8.7 11.4 12.3 7.5 10.8 86.5 27.5 13.6 12.7 2.9 5.8 1.6 2.7 7.9 14.5 7.2 4.0 0.7 6.6 2.4 3.2 4.5 10.1 16.3 12.5 141.1 5.9 2.5 17.2 8.4 7.4 6.5 20.0 17.8 7.3 12.6 0.0 0.0 0.3 0.0 0.5 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 86.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.7 0.0 0.0 0.0 1.7 29.3 0.3 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.3 0.0 0.0 3.8 5.2 0.1 0.0 0.0 0.1 0.0 0.1 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.2 0.0 0.0 0.0 0.0 0.0 153.1 2.1 6.5 0.0 19.5 0.0 30.8 381.4 229.4 189.5 469.1 11.3 54.0 15.8 89.1 196.1 84.0 8.0 78.4 272.9 264.5 405.2 9.0 1.2 494.1 12.8 11.9 11.9 19.1 11.4 12.3 13.6 12.7 14.5 12.5 17.2 12.6 8.6 6.4 20.0 0.0 24.9 2.8 0.6 0.2 0.0 0.0 0.4 0.6 1.6 1.5 5.7 1.8 0.0 0.5 55.2 0.0 0.0 0.0 0.3 0.1 0.2 14.9 0.0 7.4 0.2 0.2 0.7 2.7 1.5 0.1 13.3 0.1 6.8 1.9 56.8 0.0 0.1 0.0 0.0 182.2 63.8 0.7 0.3 155.9 1.8 6.5 159.7 0.1 259.5 1.0 0.4 0.0 1.2 0.0 4.2 0.4 0.0 0.7 1.5 0.0 0.0 0.7 0.6 0.2 0.5 0.5 1.1 1.0 28.0 0.0 0.0 2.5 FICD "HIP13, HYPE" ENSG00000198855 "FIC domain protein adenylyltransferase" Q9BVA6 12 108515277-108525837 "Enzymes, Predicted intracellular proteins" "Unfolded protein response" "Hydrolase, Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 62.8;Late spermatids: 52.0;Syncytiotrophoblasts: 31.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021390, HPA071134" Approved Approved Nucleoplasm "Intracellular and membrane" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 68: Epididymis - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 29: Early spermatids - Spermatogenesis" Nucleoplasm "HPA021390: AB_1851340, HPA071134: AB_2686347" "unprognostic (1.00e-1)" "unprognostic (8.76e-2)" "unprognostic (1.76e-2)" "prognostic favorable (4.61e-5)" "unprognostic (6.92e-2)" "unprognostic (2.68e-2)" "unprognostic (5.73e-2)" "unprognostic (2.84e-2)" "unprognostic (8.68e-2)" "unprognostic (2.57e-1)" "unprognostic (3.15e-2)" "unprognostic (1.19e-1)" "unprognostic (7.66e-2)" "unprognostic (1.56e-2)" "unprognostic (6.22e-2)" "unprognostic (3.12e-2)" "unprognostic (3.65e-2)" 3.5 7.5 5.1 5.3 6.5 2.9 3.6 6.2 5.9 6.3 4.5 3.2 3.3 3.3 12.2 1.8 3.2 3.0 2.7 5.3 6.3 3.0 8.2 3.9 4.0 7.0 6.6 2.6 12.7 4.7 11.6 3.7 6.3 4.7 2.9 2.4 8.9 6.0 2.0 2.8 2.7 3.8 6.4 3.5 4.3 7.6 6.3 2.4 10.9 2.0 5.3 3.3 1.6 7.4 2.5 6.3 2.5 5.0 5.9 4.1 6.8 16.5 8.7 7.6 5.3 3.9 2.4 3.5 6.0 8.0 9.0 3.2 2.7 1.8 6.7 6.1 4.0 2.0 4.6 5.6 23.0 3.0 7.2 1.9 3.8 10.7 15.2 9.4 5.5 3.3 1.4 11.6 6.9 5.9 4.0 3.1 2.7 2.7 10.2 2.3 3.4 8.7 3.6 4.9 2.4 1.6 7.4 3.4 8.3 3.7 5.4 2.9 6.2 7.8 2.8 13.8 6.4 22.9 4.0 1.2 10.7 2.6 5.5 11.5 2.7 4.5 6.3 4.8 7.7 4.7 4.6 5.9 2.7 2.9 2.7 5.2 5.4 3.3 5.8 15.3 3.1 1.9 5.1 6.5 6.2 5.9 5.3 6.3 7.0 6.6 6.3 6.4 6.3 7.4 3.8 0.0 3.7 6.5 6.5 0.8 4.5 4.4 1.2 5.5 5.9 3.4 2.9 4.3 3.3 7.3 2.1 6.2 4.3 2.3 5.9 5.8 62.8 2.7 6.9 4.2 1.8 2.7 2.3 9.5 5.5 6.5 5.6 7.3 13.4 3.2 4.6 5.1 6.1 13.5 2.9 4.0 0.0 2.9 3.5 52.0 3.4 4.6 7.2 1.9 2.8 11.8 5.2 3.5 4.5 7.6 1.4 9.8 15.0 8.9 1.9 2.4 4.4 7.8 13.1 4.2 4.7 9.6 9.3 1.7 3.3 31.1 4.7 5.0 2.5 4.8 FLAD1 "FAD1, PP591" ENSG00000160688 "Flavin adenine dinucleotide synthetase 1" Q8NFF5 1 154983338-154993111 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Nucleotidyltransferase, Transferase" "Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028476, HPA028486, HPA028563" Approved Supported "Plasma membrane,Cytosol" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 43: THP-1 - Innate immune response" "Cluster 25: Spermatids - Spermatogenesis" "Plasma membrane, Cytosol" "HPA028476: AB_10599974, HPA028486: AB_10600206, HPA028563: AB_10602286" "unprognostic (2.64e-1)" "unprognostic (2.60e-1)" "unprognostic (2.72e-1)" "unprognostic (3.84e-2)" "unprognostic (7.34e-2)" "unprognostic (1.45e-1)" "prognostic unfavorable (3.04e-4)" "unprognostic (1.31e-1)" "unprognostic (2.32e-1)" "unprognostic (8.08e-2)" "unprognostic (6.51e-2)" "unprognostic (9.74e-2)" "prognostic unfavorable (2.55e-6)" "unprognostic (1.67e-2)" "unprognostic (5.06e-2)" "unprognostic (5.50e-2)" "unprognostic (1.17e-2)" 21.9 21.1 19.2 17.0 20.5 14.2 23.5 20.2 20.7 20.4 19.7 22.8 20.1 19.8 20.5 26.1 19.1 11.8 28.7 20.1 19.5 21.7 32.8 17.7 22.8 20.2 20.3 15.5 18.9 18.0 15.1 14.3 20.6 24.3 18.9 9.8 21.0 13.7 34.1 32.9 24.9 17.7 19.6 30.1 22.0 19.0 20.6 16.0 22.5 32.0 23.0 22.6 21.1 21.0 33.4 52.4 32.8 56.1 27.9 20.5 62.1 24.7 20.5 35.2 30.2 46.9 40.1 38.5 48.8 23.0 18.3 42.6 63.4 51.3 23.0 40.6 47.5 31.4 42.8 33.7 38.1 46.0 39.1 29.5 65.9 40.2 42.8 17.0 41.5 40.4 51.4 30.3 30.2 71.8 31.9 32.0 71.7 72.2 53.8 52.8 16.2 88.7 33.9 45.8 54.9 75.6 38.7 86.2 50.0 63.0 74.0 68.6 26.4 21.9 30.1 28.6 39.6 47.5 63.7 66.9 26.4 36.8 36.1 29.8 35.3 23.7 34.5 33.0 38.9 39.0 31.9 33.8 37.7 34.2 29.1 28.9 7.8 26.1 41.4 38.3 37.9 37.6 19.2 20.5 20.2 20.7 20.1 19.5 20.2 20.3 20.6 19.6 20.6 21.0 12.2 9.6 10.6 9.8 19.3 26.5 18.1 37.1 23.3 15.7 16.4 15.9 39.4 20.0 22.6 25.8 6.2 42.5 16.9 22.1 31.3 24.4 25.3 15.4 12.0 14.1 12.0 19.0 8.2 28.2 42.6 12.1 25.0 12.6 8.8 21.2 11.7 27.0 27.6 15.2 6.3 20.8 28.5 18.1 11.1 77.6 10.2 14.8 14.2 5.6 34.7 23.3 32.0 4.5 8.2 25.4 14.9 9.8 18.3 26.1 30.3 32.9 19.3 17.2 6.6 9.7 18.3 22.9 20.6 25.7 27.6 36.0 20.2 23.1 25.4 20.0 FLT1 "FLT, VEGFR1" ENSG00000102755 "Fms related receptor tyrosine kinase 1" P17948 13 28300346-28495145 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" "Angiogenesis, Chemotaxis, Differentiation" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 7 "placenta: 432.4" "Cell type enhanced" "Detected in many" "Adipocytes: 411.6;Endothelial cells: 263.1;Extravillous trophoblasts: 815.4;Hepatic stellate cells: 234.9;Microglial cells: 433.8;Syncytiotrophoblasts: 1127.1" "Cancer enhanced" "Detected in all" "renal cancer: 28.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ: 71.8;BJ hTERT+: 57.2;HMC-1: 349.2;HUVEC TERT2: 64.9;WM-115: 127.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA011740, HPA014290, CAB068189, CAB068190" Enhanced Supported "Plasma membrane,Actin filaments" "Secreted to blood" NA NA 876000 87000 "Cluster 21: B-cells - Adaptive immune response" "Cluster 28: Placenta - Pregnancy" "Cluster 3: HMC-1 - Innate immune response" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" "Plasma membrane" "Actin filaments" "CAB068189: AB_2665636, CAB068190: AB_2665637, HPA011740: AB_1858737, HPA014290: AB_1858738" "unprognostic (3.33e-2)" "unprognostic (3.52e-3)" "unprognostic (1.13e-3)" "unprognostic (5.02e-2)" "unprognostic (3.65e-1)" "unprognostic (5.03e-2)" "unprognostic (8.25e-2)" "unprognostic (2.27e-3)" "unprognostic (9.91e-2)" "unprognostic (6.61e-2)" "unprognostic (2.33e-1)" "unprognostic (1.57e-1)" "prognostic unfavorable (2.19e-4)" "unprognostic (4.20e-2)" "unprognostic (6.00e-2)" "unprognostic (1.57e-1)" "unprognostic (6.32e-2)" 47.6 9.6 37.6 9.1 36.2 1.1 31.2 37.0 43.0 16.4 24.6 9.4 7.5 17.2 3.7 5.9 11.7 16.6 46.0 33.3 39.8 34.9 18.2 25.8 5.3 44.6 40.0 4.4 12.7 30.5 9.0 432.4 50.1 13.9 6.1 52.5 7.0 11.0 19.9 5.9 9.3 17.4 33.4 18.6 10.9 17.4 59.6 3.6 48.9 38.8 5.7 14.0 9.5 38.7 0.1 0.0 0.0 0.6 0.6 0.9 0.3 71.8 57.2 25.8 14.9 0.0 0.2 0.1 0.1 9.6 0.0 0.3 6.7 0.0 45.4 0.0 2.0 0.2 0.1 0.0 0.1 0.0 349.2 0.6 0.0 0.1 1.0 0.1 64.9 6.1 1.7 0.3 0.0 0.3 4.5 3.7 37.5 0.0 0.1 2.9 0.0 0.1 0.1 0.1 8.1 0.6 0.0 0.1 0.2 44.4 0.3 0.2 6.3 0.2 1.2 0.1 0.1 2.1 1.0 0.2 0.4 0.3 127.8 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.8 0.1 0.1 0.5 0.0 0.0 0.1 0.0 0.0 37.6 36.2 37.0 43.0 33.3 39.8 44.6 40.0 50.1 33.4 59.6 38.7 411.6 0.0 6.0 2.0 4.7 4.1 0.7 0.2 3.4 17.8 1.2 1.5 26.5 2.8 2.9 0.0 4.2 197.2 1.4 0.1 1.9 0.6 157.2 0.5 1.5 263.1 0.0 0.0 0.9 0.0 815.4 32.1 0.5 2.1 1.3 0.1 234.9 6.9 30.8 1.7 14.5 0.0 0.0 12.5 23.6 173.8 18.6 15.3 0.0 433.8 0.0 153.2 0.0 9.5 2.0 0.0 0.0 48.5 4.1 1.3 0.0 0.1 1.8 9.7 92.1 11.4 30.1 14.6 4.6 1.0 4.8 1127.1 2.8 1.5 0.0 1.1 FLT3 "CD135, FLK2, STK1" ENSG00000122025 "Fms related receptor tyrosine kinase 3" P36888 13 28003274-28100592 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins, RAS pathway related proteins" "Host-virus interaction" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "bone marrow: 5.3;brain: 4.9;lymphoid tissue: 6.5" "Cell type enhanced" "Detected in some" "dendritic cells: 24.4;Inhibitory neurons: 59.9;Kupffer cells: 29.1;Langerhans cells: 21.4;Macrophages: 16.9;monocytes: 39.5" "Cancer enhanced" "Detected in some" "breast cancer: 1.8" "Region enhanced" "Detected in some" "cerebellum: 4.9" "Group enriched" "Detected in many" 13 "myeloid DC: 68.7;plasmacytoid DC: 26.2" "Lineage enriched" "Detected in many" 19 "dendritic cells: 68.7" "Group enriched" "Detected in some" 11 "REH: 42.5;THP-1: 26.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA047539 Approved "Endoplasmic reticulum" NA NA 210000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 14: REH - Unknown function" "Cluster 41: Macrophages - Immune response" "Endoplasmic reticulum" "HPA047539: AB_2680080" "unprognostic (2.19e-3)" "unprognostic (3.16e-3)" "unprognostic (6.54e-3)" "unprognostic (9.96e-2)" "unprognostic (3.88e-1)" "unprognostic (3.96e-7)" "unprognostic (7.99e-3)" "unprognostic (1.65e-2)" "unprognostic (5.37e-2)" "unprognostic (1.01e-2)" "unprognostic (1.96e-1)" "unprognostic (1.03e-1)" "unprognostic (4.56e-2)" "unprognostic (3.65e-1)" "unprognostic (3.91e-2)" "unprognostic (2.51e-1)" "unprognostic (2.22e-1)" 0.5 0.1 0.3 3.0 0.2 5.3 1.5 4.9 0.8 0.5 0.1 0.7 0.3 0.2 0.1 0.6 0.4 1.6 0.1 0.2 0.5 1.5 0.5 0.7 6.5 1.3 0.9 0.1 2.8 0.0 0.0 0.0 1.7 0.1 0.8 0.0 0.4 0.2 0.0 0.7 1.6 0.8 0.8 5.7 0.6 0.6 0.8 4.7 0.1 0.3 3.6 1.3 0.1 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 3.2 0.6 0.0 0.0 42.5 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 26.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 3.6 3.4 0.0 0.8 0.0 0.2 0.0 0.0 68.7 0.0 0.0 0.0 0.1 2.0 0.0 26.2 0.0 2.7 0.3 0.2 4.9 0.8 0.2 0.5 1.3 0.9 1.7 0.8 0.8 0.8 0.0 0.0 0.0 2.3 1.5 0.3 0.0 0.0 0.0 0.0 1.5 1.0 0.4 1.5 0.0 0.0 0.0 0.0 24.4 0.0 0.0 2.7 3.7 0.3 0.1 0.2 0.0 8.2 7.4 0.0 0.0 0.2 0.0 1.1 0.0 0.0 0.7 0.1 0.5 0.0 59.9 0.0 0.0 29.1 21.4 2.3 0.0 16.9 1.8 1.9 39.5 0.0 0.0 1.5 4.2 0.1 0.0 0.0 2.2 0.0 0.0 0.3 0.0 0.0 0.0 0.2 0.1 0.2 0.6 0.0 0.6 0.0 1.7 0.0 0.0 0.0 FLT4 "PCL, VEGFR-3, VEGFR3" ENSG00000037280 "Fms related receptor tyrosine kinase 4" P35916 5 180601506-180649624 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" Angiogenesis "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in some" 7 "Adipocytes: 27.4;Endothelial cells: 27.1;Extravillous trophoblasts: 37.1;Hepatic stellate cells: 64.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 4 "MAIT T-cell: 3.8" "Lineage enriched" "Detected in single" 31 "T-cells: 3.8" "Cell line enhanced" "Detected in some" "AN3-CA: 10.1;BEWO: 12.4;HEK 293: 15.6;HL-60: 9.5;HUVEC TERT2: 9.9;JURKAT: 12.3;T-47d: 14.6;TIME: 15.7" "Low region specificity" "Detected in many" "Not detected" "Not detected" "CAB000099, HPA046519, HPA067906, HPA074389" Approved Supported "Nuclear speckles,Plasma membrane,Cell Junctions" "Secreted to blood" NA NA 20000000 290000000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 6: T47d - Mammary gland" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Nuclear speckles, Plasma membrane" "Cell Junctions" "CAB000099: , HPA046519: AB_2732527, HPA067906: AB_2732775, HPA074389: " "unprognostic (7.35e-2)" "unprognostic (1.63e-1)" "unprognostic (9.45e-3)" "unprognostic (3.81e-1)" "unprognostic (9.26e-2)" "unprognostic (3.20e-3)" "unprognostic (1.13e-2)" "unprognostic (1.80e-2)" "unprognostic (2.19e-1)" "unprognostic (1.70e-1)" "unprognostic (2.13e-2)" "unprognostic (3.69e-1)" "unprognostic (1.88e-2)" "unprognostic (9.41e-3)" "unprognostic (1.83e-1)" "unprognostic (8.26e-2)" "unprognostic (1.32e-1)" 17.2 11.3 3.5 4.7 4.6 0.8 14.7 2.6 3.4 9.0 2.6 4.9 2.8 8.0 3.0 4.4 9.8 3.8 9.7 5.1 2.6 20.1 6.2 16.9 5.5 3.4 3.0 4.5 2.0 2.3 7.8 6.4 3.6 5.6 1.3 0.3 2.0 2.5 4.7 4.0 7.2 4.1 2.8 17.6 3.5 3.1 4.2 1.0 25.7 4.1 1.4 5.6 5.5 2.7 0.1 2.5 3.2 10.1 0.0 0.0 12.4 0.3 0.1 0.0 0.0 0.4 0.3 0.3 0.9 0.1 0.6 0.4 3.4 0.2 0.3 0.1 15.6 1.2 0.5 0.5 0.1 9.5 0.3 0.2 0.1 0.2 0.4 0.3 9.9 12.3 0.4 0.4 2.1 5.6 0.1 0.5 7.0 0.3 0.6 8.2 0.1 0.1 0.1 0.3 0.3 1.1 0.1 0.2 0.1 3.1 14.6 0.3 15.7 0.2 6.9 0.2 0.1 0.2 0.1 0.1 0.1 0.2 0.1 0.1 0.0 0.0 0.5 0.0 3.8 0.0 0.2 0.8 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 3.5 4.6 2.6 3.4 5.1 2.6 3.4 3.0 3.6 2.8 4.2 2.7 27.4 0.0 1.7 0.7 0.7 0.9 0.2 0.0 1.2 0.2 1.4 1.4 4.5 0.0 0.6 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.4 0.1 0.1 27.1 0.0 0.0 0.2 0.0 37.1 0.8 0.0 0.1 2.5 2.4 64.6 0.6 1.2 0.0 0.1 0.0 0.0 3.3 0.8 0.7 0.3 0.6 0.0 3.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.8 0.0 0.2 0.0 0.7 0.7 0.1 5.2 0.1 1.1 1.0 1.8 0.2 0.0 0.1 FN3K ENSG00000167363 "Fructosamine 3 kinase" Q9H479 17 82735615-82751196 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 79.8" "Cell type enhanced" "Detected in many" "Distal tubular cells: 90.1;Proximal tubular cells: 167.2;Rod photoreceptor cells: 72.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HAP1: 34.3;Hep G2: 66.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA059151, HPA061358" Supported Approved Mitochondria NA NA 180000 "Cluster 35: Non-specific - Unknown function" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Mitochondria "HPA059151: AB_2683931, HPA061358: AB_2684490" "unprognostic (4.74e-2)" "unprognostic (9.19e-2)" "unprognostic (4.22e-2)" "prognostic favorable (1.10e-4)" "unprognostic (6.10e-2)" "unprognostic (1.39e-1)" "unprognostic (6.45e-2)" "unprognostic (9.86e-2)" "unprognostic (5.08e-2)" "unprognostic (2.61e-1)" "prognostic favorable (2.40e-4)" "unprognostic (6.66e-2)" "prognostic favorable (1.39e-6)" "unprognostic (2.68e-2)" "unprognostic (8.02e-2)" "unprognostic (4.77e-1)" "unprognostic (1.22e-2)" 14.4 47.3 47.4 2.9 64.3 12.0 8.4 64.4 56.6 10.4 36.8 15.5 22.4 9.4 7.0 4.6 12.5 6.9 47.5 46.5 54.3 49.6 48.1 7.8 2.4 63.3 56.8 22.3 18.1 21.9 22.4 5.3 62.7 12.5 9.5 13.8 28.5 12.1 23.5 5.3 14.5 6.6 49.4 4.6 17.4 5.2 55.6 1.0 10.2 10.9 2.3 8.8 7.9 79.8 1.3 16.1 4.4 23.2 6.9 5.7 2.9 2.9 2.2 5.4 2.7 21.0 3.3 0.2 3.9 2.6 4.5 0.6 34.3 2.5 2.0 1.0 2.4 12.5 12.9 66.2 18.8 0.3 10.1 4.9 9.0 2.1 0.0 5.7 10.6 1.0 22.4 0.6 1.1 1.8 0.2 0.2 2.9 7.6 13.0 2.1 0.3 0.1 11.5 4.5 7.0 22.7 5.3 1.2 15.8 3.8 15.4 4.5 2.5 0.4 1.6 5.6 4.3 1.2 0.3 0.1 0.4 0.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 47.4 64.3 64.4 56.6 46.5 54.3 63.3 56.8 62.7 49.4 55.6 79.8 3.9 3.2 2.0 8.8 1.9 1.5 3.7 1.5 14.8 41.9 4.5 3.7 5.8 4.3 2.5 31.3 47.9 11.7 2.6 5.7 90.1 3.2 0.2 11.6 3.0 5.2 5.4 49.2 10.2 1.2 2.6 8.6 47.9 25.9 1.3 6.9 4.2 5.4 8.2 32.0 13.0 10.4 6.1 1.0 3.4 0.4 5.3 5.7 12.4 5.6 1.2 36.2 1.0 6.0 17.1 1.7 7.3 3.0 9.1 3.9 28.2 167.2 2.5 72.9 0.0 6.1 9.8 0.8 4.1 12.8 1.8 8.3 3.1 18.6 9.5 3.5 FN3KRP "FLJ12171, FN3KL" ENSG00000141560 "Fructosamine 3 kinase related protein" Q9HA64 17 82716706-82730328 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 100.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA056172, HPA065831" Approved Approved Nucleoplasm NA NA 44000 "Cluster 41: Basophils - Cellular respiration" "Cluster 70: Brain - Nervous system development" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 47: Cytotrophoblasts - Unknown function" Nucleoplasm "HPA056172: AB_2683055, HPA065831: AB_2685565" "unprognostic (1.37e-1)" "unprognostic (4.95e-2)" "unprognostic (1.54e-2)" "unprognostic (2.09e-1)" "prognostic unfavorable (3.26e-4)" "unprognostic (2.31e-1)" "unprognostic (1.25e-2)" "unprognostic (8.67e-2)" "unprognostic (1.26e-1)" "unprognostic (1.99e-1)" "unprognostic (8.84e-2)" "unprognostic (4.32e-3)" "unprognostic (1.60e-2)" "unprognostic (1.31e-1)" "unprognostic (2.23e-2)" "unprognostic (3.97e-2)" "unprognostic (3.71e-2)" 23.2 22.1 40.6 13.3 43.7 18.8 19.7 43.3 41.3 23.4 35.1 22.9 15.3 23.1 19.4 20.4 20.4 16.6 16.1 41.1 41.7 23.9 29.3 16.3 18.5 42.5 41.6 32.1 19.3 18.4 17.2 21.8 43.2 20.8 18.0 17.8 22.2 23.2 11.4 23.6 19.4 22.1 42.9 20.9 20.6 13.7 41.7 16.6 16.7 10.6 22.8 19.7 20.7 48.3 31.4 122.3 33.6 44.5 15.9 30.3 27.2 56.9 31.8 54.5 44.3 64.9 21.8 25.6 37.0 46.6 50.5 35.3 30.1 43.5 48.7 17.2 54.3 42.6 66.2 77.5 28.3 30.7 23.2 27.8 50.9 51.7 28.1 33.4 39.8 35.9 42.5 15.8 70.7 59.8 58.8 45.2 15.2 68.7 53.5 44.0 83.4 40.3 38.9 58.7 27.6 58.1 93.7 42.7 47.3 57.4 69.8 43.6 34.8 103.3 35.9 74.2 85.3 32.1 37.8 64.8 48.1 38.2 49.0 32.0 21.9 30.6 29.6 24.7 29.5 23.9 28.8 28.8 18.2 24.8 32.5 24.3 3.4 32.1 13.8 36.0 29.7 26.0 40.6 43.7 43.3 41.3 41.1 41.7 42.5 41.6 43.2 42.9 41.7 48.3 14.3 12.8 11.1 5.5 13.9 15.0 26.0 26.0 15.4 18.1 13.3 15.6 6.9 25.8 15.3 11.0 8.4 100.3 20.0 12.2 23.5 20.6 2.0 10.7 13.0 14.8 7.8 31.2 7.6 11.1 45.3 18.1 13.3 22.3 13.3 18.6 10.8 12.1 33.8 3.3 6.7 15.4 22.4 11.2 11.3 4.2 28.3 12.8 23.2 6.5 20.9 36.1 17.5 5.0 11.8 17.8 15.9 31.6 27.6 15.5 11.1 28.2 10.0 18.5 13.1 13.6 20.9 18.3 36.2 18.0 15.3 62.5 17.2 22.3 15.6 24.0 FNTA "FPTA, PGGT1A, PTAR2" ENSG00000168522 "Farnesyltransferase, CAAX box, alpha" P49354 8 43034194-43085788 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "Prenyltransferase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010149, HPA018830" Approved Approved Cytosol NA NA 170000 "Cluster 26: Non-specific - Mitochondria" "Cluster 70: Brain - Nervous system development" "Cluster 30: Epithelial cell lines - Translation" "Cluster 47: Cytotrophoblasts - Unknown function" Cytosol "CAB010149: AB_2106299, HPA018830: AB_1848992" "unprognostic (2.09e-1)" "unprognostic (1.35e-1)" "unprognostic (2.90e-1)" "unprognostic (1.86e-3)" "unprognostic (2.64e-1)" "unprognostic (4.70e-3)" "unprognostic (1.83e-2)" "unprognostic (3.69e-2)" "unprognostic (1.70e-2)" "unprognostic (5.37e-2)" "unprognostic (3.25e-2)" "unprognostic (4.10e-1)" "prognostic unfavorable (2.94e-12)" "unprognostic (3.63e-2)" "unprognostic (2.33e-1)" "unprognostic (3.19e-2)" "unprognostic (1.29e-3)" 53.6 33.4 57.7 26.3 69.3 26.8 46.1 74.0 74.0 41.3 52.7 46.3 35.9 34.0 43.2 45.4 33.4 27.1 48.1 54.2 63.7 37.4 47.2 34.7 45.5 75.1 64.8 33.0 43.9 34.3 36.6 50.0 73.6 38.3 32.5 33.8 36.5 34.1 74.3 51.0 32.9 31.4 73.2 36.7 35.4 26.9 61.9 39.9 31.6 64.7 44.2 40.9 43.1 87.6 78.8 37.5 50.9 16.7 88.6 112.5 43.4 44.9 52.4 50.1 46.3 62.1 56.9 88.5 35.5 54.1 67.6 41.9 63.1 71.5 59.4 26.2 42.2 70.9 25.5 54.2 112.7 30.4 35.8 87.6 119.0 36.3 104.2 74.4 89.4 47.9 86.1 50.4 58.5 9.9 72.3 47.1 91.3 66.4 27.1 63.1 83.0 47.8 70.5 58.4 29.7 47.4 56.6 47.3 78.9 59.1 59.1 55.3 69.9 17.9 22.1 68.6 48.0 47.7 46.2 89.2 43.0 56.4 41.3 3.1 7.7 14.3 9.5 10.7 11.3 14.1 9.7 12.6 13.3 15.2 12.9 12.9 4.3 16.1 7.8 12.6 14.3 6.4 57.7 69.3 74.0 74.0 54.2 63.7 75.1 64.8 73.6 73.2 61.9 87.6 68.7 57.7 20.3 33.0 57.4 87.7 82.3 55.3 58.1 22.5 35.5 34.8 44.9 34.3 41.2 33.1 37.5 135.6 69.1 29.6 70.5 73.0 41.2 40.7 55.1 55.8 32.2 38.9 27.9 70.1 124.4 58.7 28.5 46.2 32.4 58.6 56.0 25.9 80.5 20.2 31.9 39.6 34.6 47.5 60.7 52.8 48.1 49.2 94.3 33.7 75.7 42.8 69.0 25.6 79.8 69.4 41.2 60.2 40.8 109.3 67.0 54.8 46.7 57.5 52.6 56.2 47.2 65.9 37.1 73.9 95.6 207.6 60.4 69.6 49.1 76.6 FNTB FPTB ENSG00000257365 "Farnesyltransferase, CAAX box, beta" P49356 14 64986895-65062652 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "Prenyltransferase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 70.0" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" HPA062743 Uncertain Approved Centrosome NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 70: Brain - Nervous system development" "Cluster 17: WM-115 - Nervous system development" "Cluster 51: Myeloid cells - Hemostasis" Centrosome "HPA062743: AB_2684861" "unprognostic (2.79e-1)" "unprognostic (1.50e-2)" "unprognostic (1.54e-1)" "unprognostic (8.57e-3)" "unprognostic (1.88e-1)" "unprognostic (6.88e-2)" "prognostic unfavorable (6.03e-4)" "unprognostic (6.21e-2)" "unprognostic (3.11e-2)" "unprognostic (1.46e-2)" "unprognostic (1.70e-2)" "unprognostic (2.11e-1)" "unprognostic (2.49e-3)" "unprognostic (2.36e-2)" "unprognostic (3.60e-1)" "unprognostic (5.56e-2)" "unprognostic (1.11e-3)" 8.7 8.7 15.9 5.1 30.2 2.9 7.8 40.7 20.1 7.7 13.5 6.5 5.9 6.6 8.4 13.3 9.5 5.9 12.9 14.5 20.7 8.2 5.8 6.7 5.7 55.0 34.2 7.3 5.6 13.0 7.0 8.7 46.5 9.1 7.7 6.1 9.2 9.3 18.1 11.8 5.2 11.6 36.7 4.7 5.5 9.5 30.7 6.5 5.8 19.7 8.3 7.6 8.9 70.0 37.1 31.9 20.4 12.5 13.9 11.9 14.6 20.2 14.7 22.4 23.0 15.9 14.6 6.0 12.0 21.1 13.2 24.1 47.5 15.1 18.3 9.0 15.9 23.2 8.0 28.1 9.0 8.3 32.2 9.7 14.3 9.4 5.7 22.4 19.1 10.9 13.7 8.4 13.1 30.9 13.3 22.6 8.4 23.1 29.9 12.2 17.6 7.6 16.2 15.7 12.0 13.5 11.9 24.4 30.2 15.9 22.7 14.0 15.2 16.2 34.7 8.4 14.2 5.7 5.6 6.6 18.3 10.3 39.4 21.9 12.8 11.5 3.8 9.9 9.6 2.5 6.2 5.1 7.4 1.7 4.7 3.7 3.4 4.0 5.1 5.8 6.2 7.4 15.9 30.2 40.7 20.1 14.5 20.7 55.0 34.2 46.5 36.7 30.7 70.0 3.9 12.8 2.2 0.0 1.6 2.4 3.5 4.3 2.8 4.6 6.2 6.6 8.3 2.8 5.6 3.7 2.1 15.9 2.4 4.3 0.0 6.6 9.2 3.9 3.0 4.5 7.7 7.8 0.0 4.8 15.3 4.9 4.1 4.8 0.0 12.7 5.0 8.0 8.1 5.0 0.0 5.9 6.1 8.1 2.5 6.0 5.6 15.7 5.4 0.0 7.5 7.6 2.1 0.0 0.0 4.2 1.9 8.6 2.1 4.7 4.0 6.0 4.0 4.1 19.7 5.1 5.5 2.7 4.7 6.7 3.7 8.2 2.5 7.3 5.3 3.3 FPGT GFPP ENSG00000254685 "Fucose-1-phosphate guanylyltransferase" O14772 1 74198212-74234086 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA072331 Uncertain Vesicles NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 1: Thyroid gland - Transcription" "Cluster 18: U-2197 - ECM organization" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Vesicles "HPA072331: " "unprognostic (1.53e-1)" "unprognostic (1.94e-1)" "unprognostic (8.18e-3)" "unprognostic (4.32e-2)" "unprognostic (5.14e-2)" "unprognostic (2.46e-1)" "prognostic unfavorable (2.30e-4)" "unprognostic (1.86e-1)" "unprognostic (5.14e-2)" "unprognostic (2.58e-1)" "unprognostic (7.59e-2)" "unprognostic (1.33e-1)" "unprognostic (3.59e-3)" "unprognostic (1.44e-1)" "unprognostic (7.88e-2)" "unprognostic (3.53e-2)" "unprognostic (1.91e-1)" 10.5 10.5 3.7 9.9 5.6 4.2 12.9 5.4 4.9 8.9 6.2 12.0 11.7 8.7 10.6 10.7 9.2 13.2 8.7 4.0 5.0 15.4 14.1 8.9 9.0 5.8 5.4 13.3 10.4 13.5 5.3 10.8 6.2 9.9 11.1 6.8 10.6 8.5 4.9 12.0 12.3 8.8 5.3 10.1 12.6 8.1 5.0 8.5 19.5 5.6 9.8 8.3 6.0 8.3 12.4 10.1 7.5 11.0 17.0 15.8 11.2 16.0 10.6 10.8 12.7 5.7 9.1 7.6 19.2 9.5 12.2 10.3 13.6 14.6 17.1 15.4 5.8 17.3 11.1 9.7 14.1 13.2 12.7 13.1 18.6 10.8 5.1 7.4 11.3 10.5 18.2 8.8 17.1 3.3 7.4 2.7 8.2 15.9 9.1 7.8 17.5 10.8 9.5 8.9 7.8 7.8 11.8 17.1 18.6 2.4 20.6 14.9 10.3 4.7 8.8 25.8 12.2 9.6 7.3 10.2 19.0 12.8 16.2 19.5 20.1 21.7 5.5 20.5 6.5 5.0 5.5 5.2 12.6 6.1 6.2 5.6 6.1 5.8 18.4 1.2 7.6 10.7 3.7 5.6 5.4 4.9 4.0 5.0 5.8 5.4 6.2 5.3 5.0 8.3 7.1 6.4 3.2 0.0 3.0 6.8 4.9 13.3 4.6 7.1 7.6 5.6 10.2 14.3 9.3 11.0 2.1 12.7 2.5 7.8 19.6 5.3 8.9 6.0 4.8 4.9 6.0 9.5 0.0 7.1 11.0 7.0 4.1 4.2 5.1 4.9 6.4 9.8 15.1 3.3 0.0 7.3 6.1 9.4 4.6 7.3 10.2 10.3 5.4 0.0 9.0 10.6 8.2 0.0 0.0 6.5 8.9 5.7 1.2 2.5 11.0 15.3 12.7 5.5 26.3 5.8 7.2 9.7 10.4 5.7 6.5 6.2 5.2 4.9 7.3 3.0 FRK "GTK, PTK5, RAK" ENSG00000111816 "Fyn related Src family tyrosine kinase" P42685 6 115931149-116060891 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" "FDA approved drug targets, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 13.7" "Cell type enhanced" "Detected in many" "Early spermatids: 89.4;Oligodendrocytes: 97.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "OE19: 18.3;RT4: 7.6" "Not detected" "Not detected" "Not detected" "Not detected" "CAB025217, HPA030479, HPA072590" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 17: Basophils - Unknown function" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 21: OE19 - Mitochondria" "Cluster 44: Endometrium - Transcription" Nucleoplasm Cytosol "CAB025217: , HPA030479: AB_2732457, HPA072590: " "unprognostic (7.70e-3)" "unprognostic (1.99e-2)" "unprognostic (1.11e-1)" "unprognostic (4.68e-3)" "unprognostic (1.96e-1)" "unprognostic (3.49e-2)" "unprognostic (2.09e-1)" "unprognostic (1.58e-1)" "unprognostic (4.23e-2)" "unprognostic (5.82e-3)" "unprognostic (1.45e-1)" "unprognostic (7.54e-2)" "prognostic favorable (9.66e-7)" "unprognostic (1.52e-2)" "unprognostic (1.34e-1)" "unprognostic (2.02e-2)" "unprognostic (1.10e-1)" 0.8 1.1 1.3 1.2 2.1 1.5 2.4 5.8 5.0 1.8 13.7 4.6 6.2 1.0 2.5 2.9 2.6 2.6 1.8 1.8 0.0 9.0 6.8 1.8 0.7 0.3 0.1 0.9 2.8 1.0 0.4 0.8 1.0 2.2 4.8 2.9 4.0 2.4 2.2 1.9 6.3 0.8 0.2 0.9 4.9 1.9 1.1 1.2 1.0 0.8 1.6 2.1 1.0 5.7 2.5 4.0 0.5 0.9 0.2 0.2 0.6 0.5 0.1 0.0 0.1 3.1 3.8 0.9 3.5 0.5 0.5 5.8 0.2 1.1 0.1 3.3 0.3 1.3 3.3 2.7 0.2 0.9 0.7 0.2 1.5 0.3 0.4 0.4 0.2 0.6 0.6 2.3 1.0 1.3 0.7 0.5 1.0 18.3 0.7 1.1 3.3 1.2 4.8 7.6 0.7 0.8 0.7 5.1 0.5 0.9 1.5 0.7 0.8 1.0 1.0 0.7 0.5 3.6 2.7 1.6 1.1 0.6 0.6 0.9 0.2 0.2 0.4 0.1 0.5 0.2 0.3 0.4 0.1 0.4 0.2 0.3 0.8 0.3 0.2 0.3 0.2 0.0 1.3 2.1 5.8 5.0 1.8 0.0 0.3 0.1 1.0 0.2 1.1 5.7 0.4 0.0 10.3 10.4 0.5 2.7 20.8 23.3 6.8 0.6 7.3 2.9 9.2 11.5 22.6 23.9 0.0 4.4 0.1 34.9 11.7 20.3 89.4 28.1 1.7 0.7 19.8 0.0 12.2 16.4 4.3 3.5 29.0 30.4 3.8 0.2 1.4 21.9 0.9 6.7 7.7 14.5 34.6 0.6 0.4 38.1 0.6 0.6 0.0 1.0 1.0 0.2 0.0 2.5 97.8 21.9 23.3 1.2 0.5 23.4 49.3 28.4 36.6 0.3 13.1 9.9 16.2 4.6 1.0 16.4 3.1 0.8 1.0 2.3 19.1 46.2 FTCD ENSG00000160282 "Formimidoyltransferase cyclodeaminase" O95954 21 46136262-46155579 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Histidine metabolism" "Lyase, Multifunctional enzyme, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "liver: 939.8" "Cell type enhanced" "Detected in many" "Cholangiocytes: 131.5;Early spermatids: 104.7;Hepatocytes: 444.9;Late spermatids: 124.3;Proximal tubular cells: 395.1" "Cancer enriched" "Detected in some" 8 "liver cancer: 87.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 30 "Hep G2: 92.9" "Not detected" "Not detected" "Not detected" "Not detected" "HPA020073, HPA030928, HPA030929, HPA036114" Enhanced Approved "Plasma membrane,Cytosol" No NA 1600000 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 85: Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Cytosol "Plasma membrane" "HPA020073: AB_1849005, HPA030928: AB_2673664, HPA030929: AB_2673665, HPA036114: AB_2674947" "unprognostic (1.71e-1)" "unprognostic (2.27e-1)" "unprognostic (4.62e-5)" "unprognostic (2.90e-2)" "unprognostic (1.13e-1)" "unprognostic (2.96e-1)" "prognostic favorable (1.70e-4)" "unprognostic (1.85e-1)" "unprognostic (2.67e-1)" "unprognostic (1.99e-1)" "prognostic favorable (6.78e-5)" "unprognostic (1.80e-1)" "prognostic favorable (5.78e-4)" "unprognostic (3.80e-2)" "unprognostic (3.60e-1)" "unprognostic (9.37e-2)" "unprognostic (2.10e-1)" 0.4 1.7 5.4 0.2 6.8 0.0 0.4 3.6 8.4 1.3 3.0 1.3 1.3 1.2 0.4 0.3 0.9 0.1 1.6 4.9 4.7 155.7 939.8 0.2 0.2 4.6 3.9 3.0 4.0 0.0 3.4 0.0 5.6 4.2 0.0 0.0 0.2 0.6 0.4 0.3 1.7 0.0 3.5 0.5 0.5 13.9 4.4 0.0 0.9 0.0 0.0 1.3 1.0 5.5 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.1 0.0 3.1 0.0 0.3 0.2 0.0 0.7 0.0 0.0 0.0 0.0 0.1 0.6 0.6 0.0 92.9 0.0 0.6 0.3 0.1 0.0 0.2 0.0 0.0 0.0 0.2 0.7 0.0 0.0 0.7 0.0 0.0 1.9 0.0 0.1 0.2 0.2 0.0 0.2 0.0 0.9 0.3 0.0 0.1 0.1 0.1 0.1 0.0 0.0 0.3 0.4 0.5 0.0 0.3 0.1 0.0 0.4 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 5.4 6.8 3.6 8.4 4.9 4.7 4.6 3.9 5.6 3.5 4.4 5.5 0.0 0.0 0.0 1.0 8.1 0.1 0.0 0.0 0.0 1.3 0.2 0.5 1.5 131.5 0.0 9.2 0.0 0.0 0.1 0.0 46.9 0.0 104.7 0.1 0.4 1.8 0.0 61.5 10.5 0.0 0.0 0.6 0.0 0.2 0.0 0.6 30.4 444.9 0.1 3.3 5.9 0.1 0.0 28.9 0.0 124.3 3.1 1.6 0.0 1.0 0.0 0.2 0.0 1.0 18.5 0.0 0.1 2.6 0.0 0.5 0.3 395.1 0.0 0.4 0.0 0.2 0.5 39.2 17.9 0.2 0.4 0.0 3.6 0.1 0.2 0.1 FTSJ1 "CDLIV, JM23, MRX44, MRX9, SPB1, TRM7, TRMT7" ENSG00000068438 "FtsJ RNA 2'-O-methyltransferase 1" Q9UET6 X 48476021-48486364 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "tRNA processing" "Methyltransferase, Transferase" "Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 75.7;Pancreatic endocrine cells: 60.1;Plasma cells: 59.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA002718 Approved Approved Cytosol NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 50: Non-specific - Ribosome" "Cluster 30: Epithelial cell lines - Translation" "Cluster 55: Plasma cells - Humoral immune response" Cytosol "HPA002718: AB_1078914" "unprognostic (2.56e-2)" "unprognostic (1.24e-2)" "unprognostic (1.44e-1)" "unprognostic (3.37e-1)" "unprognostic (2.13e-1)" "unprognostic (6.77e-2)" "prognostic unfavorable (1.74e-5)" "unprognostic (1.95e-2)" "unprognostic (2.39e-1)" "unprognostic (3.96e-3)" "unprognostic (2.06e-3)" "unprognostic (7.82e-2)" "prognostic unfavorable (5.24e-10)" "unprognostic (2.61e-1)" "unprognostic (1.49e-1)" "unprognostic (1.56e-2)" "unprognostic (1.23e-1)" 14.6 15.2 5.7 14.5 6.8 16.0 13.8 6.5 9.0 16.0 5.2 10.2 8.2 13.8 4.6 14.9 12.1 8.6 11.4 6.6 6.7 10.1 9.8 13.3 16.2 6.0 6.2 12.7 16.8 12.4 12.2 8.4 6.2 10.3 7.7 5.7 15.4 12.8 14.8 14.2 10.2 12.3 6.2 13.7 13.7 9.8 5.8 14.8 14.3 10.9 13.4 14.3 14.1 6.6 75.9 51.1 19.1 76.4 27.1 27.9 31.3 36.0 34.3 51.4 40.5 30.8 102.6 43.6 26.3 55.4 32.4 49.8 38.3 127.3 23.1 33.4 36.3 27.8 62.5 35.5 75.8 38.5 67.4 26.0 63.0 64.8 63.2 28.5 36.4 49.2 24.1 35.2 67.4 42.6 50.4 27.3 43.2 32.1 86.6 40.4 62.7 91.2 48.3 25.4 26.0 25.5 57.4 31.1 27.5 22.1 35.7 21.7 35.8 40.6 54.9 85.3 44.9 47.6 39.8 31.4 89.6 71.3 43.6 19.5 23.7 19.1 34.6 27.1 43.0 27.2 29.5 35.4 28.3 31.5 26.8 34.5 3.4 30.3 27.8 19.1 30.2 27.8 5.7 6.8 6.5 9.0 6.6 6.7 6.0 6.2 6.2 6.2 5.8 6.6 15.1 6.4 11.0 3.9 20.6 12.7 11.4 30.7 14.2 4.5 8.5 8.8 6.7 4.3 23.8 7.3 2.1 5.3 19.7 6.6 17.6 21.2 49.5 11.1 11.8 13.4 5.4 14.7 4.4 18.2 28.7 12.4 16.3 15.2 8.8 9.2 6.4 5.9 17.0 3.3 4.3 11.3 10.2 8.4 10.6 75.7 10.8 11.0 5.4 5.6 8.9 5.7 19.6 3.0 5.8 60.1 2.7 8.6 59.5 17.0 4.8 11.3 14.0 6.5 13.1 9.6 16.7 7.5 10.1 15.0 10.9 5.7 17.0 10.7 9.4 26.5 FUT1 "H, HSC" ENSG00000174951 "Fucosyltransferase 1 (H blood group)" P19526 19 48748011-48755390 "Blood group antigen proteins, Enzymes, Metabolic proteins, Predicted membrane proteins" "Blood group antigen, Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "pancreas: 27.5" "Cell type enhanced" "Detected in many" "Adipocytes: 13.8;Endothelial cells: 8.5;Langerhans cells: 41.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "basophil: 1.3" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "CACO-2: 9.3;HEL: 11.5;RT4: 11.2" "Not detected" "Not detected" "Low region specificity" "Detected in all" NA NA 15000 "Cluster 11: Basophils - Unknown function" "Cluster 25: Pancreas - Digestion" "Cluster 3: HMC-1 - Innate immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "unprognostic (2.90e-2)" "unprognostic (3.09e-2)" "unprognostic (8.05e-3)" "unprognostic (4.65e-3)" "unprognostic (2.92e-3)" "unprognostic (8.73e-2)" "unprognostic (2.58e-2)" "unprognostic (3.34e-2)" "unprognostic (2.36e-1)" "unprognostic (1.38e-1)" "unprognostic (4.19e-2)" "unprognostic (1.29e-1)" "prognostic favorable (3.99e-4)" "unprognostic (1.33e-1)" "unprognostic (3.22e-2)" "unprognostic (8.67e-3)" "unprognostic (3.98e-2)" 3.8 1.6 2.3 0.6 3.5 2.9 3.1 5.2 3.3 1.2 1.0 0.7 1.9 0.9 0.9 2.8 2.0 1.0 3.8 3.1 1.5 4.1 1.0 10.6 0.7 1.6 1.6 0.3 27.5 3.3 2.7 4.2 1.7 1.4 0.5 0.3 1.4 1.0 1.7 1.6 0.6 0.9 1.3 5.4 13.6 1.6 2.0 0.7 1.9 2.9 1.4 1.3 1.4 1.8 3.8 0.1 0.2 0.2 0.0 0.0 1.8 0.2 0.1 0.2 0.2 9.3 5.4 0.4 0.4 0.3 0.8 6.2 1.9 5.8 0.2 0.1 0.9 11.5 0.4 0.2 2.6 0.4 4.9 0.0 9.1 0.4 4.1 0.1 4.1 2.0 0.6 1.8 0.0 4.4 0.2 7.3 1.1 7.5 0.5 0.3 0.0 1.9 0.3 11.2 8.5 0.5 0.5 8.0 0.2 0.4 5.2 0.3 4.0 0.4 2.6 0.2 0.4 1.5 4.3 1.1 0.1 0.3 0.4 1.3 0.2 0.1 0.1 0.0 0.0 0.2 0.1 0.1 0.0 0.2 0.1 0.1 0.5 0.3 0.0 0.2 0.0 0.0 2.3 3.5 5.2 3.3 3.1 1.5 1.6 1.6 1.7 1.3 2.0 1.8 13.8 3.2 1.7 0.0 0.0 2.5 0.7 4.1 1.2 0.4 1.2 0.9 1.1 2.8 2.3 0.0 2.1 0.4 0.0 0.1 1.9 1.7 0.0 1.3 0.3 8.5 1.2 6.5 1.3 2.4 0.3 0.8 4.1 3.4 1.3 0.0 6.8 0.0 0.3 0.0 0.4 1.2 2.0 0.8 41.9 0.1 0.9 1.9 5.4 1.0 0.0 0.0 0.0 0.0 0.1 3.6 0.0 0.0 0.1 0.9 0.1 0.0 0.9 0.2 0.0 0.6 0.9 0.1 0.1 2.4 1.7 0.4 0.3 0.0 0.1 0.6 FUT2 "SE, Se2, SEC2, sej" ENSG00000176920 "Fucosyltransferase 2" Q10981 19 48695971-48705951 "Blood group antigen proteins, Enzymes, Metabolic proteins, Predicted membrane proteins" "Blood group antigen, Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 44.5;salivary gland: 66.2;stomach 1: 28.9" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 56.4;Club cells: 69.4;Distal enterocytes: 110.0;Gastric mucus-secreting cells: 83.6;Ionocytes: 57.0;Paneth cells: 75.5;Proximal enterocytes: 182.4;Undifferentiated cells: 62.9" "Low cancer specificity" "Detected in many" "Region enriched" "Detected in some" 4 "cerebellum: 5.5" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Group enriched" "Detected in some" 7 "CAPAN-2: 63.6;OE19: 76.1" "Region enhanced" "Detected in some" "cerebellum: 2.3" "Low region specificity" "Detected in all" HPA014402 Uncertain Uncertain "Plasma membrane,Cytosol" NA NA "Cluster 17: Basophils - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Plasma membrane, Cytosol" "HPA014402: AB_1849194" "unprognostic (2.95e-2)" "unprognostic (6.07e-2)" "unprognostic (2.80e-3)" "unprognostic (4.63e-3)" "unprognostic (2.63e-1)" "prognostic favorable (5.83e-4)" "unprognostic (6.30e-3)" "unprognostic (6.55e-3)" "unprognostic (1.58e-1)" "unprognostic (8.44e-2)" "unprognostic (7.89e-2)" "unprognostic (5.11e-1)" "unprognostic (4.04e-2)" "unprognostic (6.52e-3)" "unprognostic (1.73e-1)" "unprognostic (3.12e-1)" "unprognostic (2.87e-1)" 0.2 0.6 0.8 6.2 0.9 0.3 1.7 5.5 1.2 16.0 0.0 23.5 44.5 1.1 0.1 26.0 2.6 13.5 0.5 0.9 0.0 1.0 0.3 0.9 0.5 0.2 0.1 1.1 5.2 0.1 2.0 0.1 0.3 1.4 19.8 0.9 66.2 2.9 0.7 4.8 21.9 0.8 0.0 0.6 28.9 0.8 0.4 0.6 0.7 0.0 6.6 6.3 9.7 0.6 2.0 1.5 0.3 0.9 0.0 0.0 0.2 0.2 0.0 0.0 0.0 7.2 63.6 0.7 0.5 0.0 0.3 10.6 0.0 0.0 0.0 0.5 0.5 0.6 0.6 0.3 0.0 0.1 0.6 0.0 0.1 0.0 0.0 1.0 0.0 1.2 0.1 0.8 0.1 0.5 0.7 1.5 0.4 76.1 0.3 0.5 0.2 3.0 0.0 0.6 3.4 0.5 0.3 0.6 0.1 0.4 9.5 0.1 0.3 0.4 0.4 0.5 0.2 0.7 0.5 0.1 0.3 0.4 0.2 1.1 0.1 0.1 0.4 0.1 0.2 0.3 0.5 0.2 0.1 0.3 0.4 0.1 0.5 0.2 0.1 0.4 0.6 0.2 0.8 0.9 5.5 1.2 0.9 0.0 0.2 0.1 0.3 0.0 0.4 0.6 0.5 0.0 0.6 0.7 0.6 0.9 2.3 56.4 5.7 2.5 6.1 3.0 0.8 32.9 69.4 20.2 2.1 0.1 0.4 110.0 1.9 4.7 0.5 8.4 2.7 0.7 11.4 0.0 2.3 46.5 0.0 0.5 83.6 23.9 0.0 0.1 0.0 0.1 0.1 0.0 1.4 42.1 57.0 0.3 0.3 0.2 0.0 0.3 1.8 0.0 0.3 0.5 2.1 0.5 1.2 31.8 75.5 0.0 0.2 2.9 182.4 0.1 37.8 4.2 0.0 1.2 2.4 0.3 0.2 9.9 1.4 0.1 0.8 0.3 62.9 19.4 FUT3 "CD174, LE" ENSG00000171124 "Fucosyltransferase 3 (Lewis blood group)" P21217 19 5842888-5851474 "Blood group antigen proteins, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Blood group antigen, Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 158.7;intestine: 72.3;retina: 79.3;salivary gland: 84.2" "Cell type enhanced" "Detected in many" "Distal enterocytes: 154.7;Intestinal goblet cells: 78.7;Pancreatic endocrine cells: 49.0;Paneth cells: 88.9;Proximal enterocytes: 85.2;Undifferentiated cells: 65.6" "Cancer enhanced" "Detected in many" "colorectal cancer: 41.4" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A-431: 46.3;hTCEpi: 6.9;OE19: 20.6;RH-30: 14.8;SK-BR-3: 7.1" HPA046966 Supported NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 37: Intestine - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA046966: AB_2679879" "prognostic unfavorable (6.86e-4)" "unprognostic (2.59e-1)" "unprognostic (1.06e-1)" "unprognostic (9.12e-2)" "unprognostic (8.58e-3)" "unprognostic (1.63e-3)" "unprognostic (3.88e-2)" "unprognostic (2.03e-2)" "unprognostic (4.02e-2)" "unprognostic (3.98e-2)" "unprognostic (4.21e-2)" "unprognostic (2.99e-1)" "prognostic favorable (8.22e-7)" "unprognostic (5.66e-3)" "unprognostic (9.56e-2)" "unprognostic (4.30e-2)" "unprognostic (1.07e-1)" 0.5 0.0 0.4 12.6 0.6 0.7 1.2 0.5 0.7 25.9 0.5 72.3 47.7 0.3 0.0 158.7 1.3 22.4 0.2 0.4 1.2 9.8 2.3 5.2 0.1 0.8 0.5 0.1 9.1 0.0 0.6 0.1 0.7 2.2 44.5 79.3 84.2 8.5 0.1 3.2 56.3 2.8 0.2 0.2 20.8 4.0 0.6 0.2 0.0 0.0 15.9 3.0 53.2 0.7 46.3 0.0 0.2 0.2 0.0 0.0 3.3 0.0 0.0 0.0 0.0 0.1 5.2 0.0 0.6 0.0 0.0 2.0 0.0 0.4 0.0 0.2 0.2 0.0 0.0 0.3 0.0 0.0 0.1 0.0 6.9 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.2 0.1 20.6 0.0 0.0 14.8 1.6 0.0 0.6 0.0 0.2 0.0 7.1 0.2 0.1 0.1 0.4 0.0 0.2 0.1 0.1 0.3 0.3 0.3 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.4 0.6 0.5 0.7 0.4 1.2 0.8 0.5 0.7 0.2 0.6 0.7 0.1 0.0 4.8 0.3 1.1 0.0 3.0 23.6 0.0 1.8 1.7 0.3 0.3 11.5 36.4 0.0 0.0 0.1 0.0 154.7 0.0 43.2 4.9 1.1 0.1 0.5 13.8 0.0 0.1 14.2 0.4 0.0 18.3 0.6 8.9 0.1 0.0 0.4 0.0 0.0 0.0 78.7 14.2 0.0 0.0 8.7 0.0 0.2 0.0 1.0 0.0 1.9 0.0 0.0 0.1 49.0 88.9 0.0 0.1 0.9 85.2 16.5 22.8 34.9 0.0 0.0 1.5 0.5 0.2 6.5 0.0 0.3 0.5 0.0 65.6 27.3 FUT5 FUC-TV ENSG00000130383 "Fucosyltransferase 5" Q11128 19 5865826-5870540 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "MCF7: 1.1" HPA046966 Uncertain NA NA "Cluster 40: Non-specific - Basic cellular processes" "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" "HPA046966: AB_2679879" "unprognostic (7.72e-2)" "unprognostic (3.59e-1)" "unprognostic (5.03e-2)" "unprognostic (1.20e-1)" 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 FUT6 "FCT3A, FLJ40754, FT1A, FucT-VI" ENSG00000156413 "Fucosyltransferase 6" P51993 19 5830408-5839722 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 79.4;kidney: 36.1;salivary gland: 45.7" "Cell type enhanced" "Detected in some" "Distal enterocytes: 35.6;Intestinal goblet cells: 39.4;Paneth cells: 21.5;Proximal enterocytes: 101.4;Proximal tubular cells: 45.3;Undifferentiated cells: 29.0" "Cancer enhanced" "Detected in many" "colorectal cancer: 9.8" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "basophil: 1.3" "Low lineage specificity" "Detected in single" "Group enriched" "Detected in some" 6 "Hep G2: 10.5;RPMI-8226: 4.0" "HPA043707, HPA046966" Approved Supported "Golgi apparatus" "Secreted to blood" NA NA 51000 "Cluster 10: Basophils - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 45: Enterocytes - Digestion" "Golgi apparatus" "HPA043707: AB_2678628, HPA046966: AB_2679879" "unprognostic (3.65e-2)" "unprognostic (3.00e-3)" "unprognostic (2.13e-3)" "unprognostic (2.78e-3)" "unprognostic (6.35e-2)" "prognostic favorable (2.12e-4)" "unprognostic (8.02e-2)" "unprognostic (6.68e-3)" "unprognostic (4.01e-2)" "unprognostic (8.53e-2)" "unprognostic (2.62e-2)" "unprognostic (4.94e-2)" "prognostic favorable (3.17e-8)" "unprognostic (1.05e-2)" "unprognostic (1.38e-1)" "unprognostic (2.40e-1)" "unprognostic (1.27e-1)" 0.1 0.0 0.1 2.6 0.1 0.4 1.7 0.2 0.1 17.3 0.4 17.3 28.6 0.3 0.0 79.4 0.6 9.3 0.0 0.1 0.1 36.1 12.4 0.2 0.1 0.1 0.1 0.0 3.7 0.0 0.0 0.0 0.1 0.2 11.6 2.0 45.7 2.5 0.0 0.1 27.0 0.4 0.1 0.1 4.8 0.2 0.1 0.0 0.0 0.0 6.7 0.0 26.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 1.0 0.2 10.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.2 0.0 0.0 0.7 4.0 0.2 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.2 0.0 1.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.6 0.0 0.1 0.0 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.2 0.2 0.0 0.5 0.0 0.7 0.0 0.4 3.5 0.0 0.4 3.7 1.9 0.3 18.6 15.7 1.8 0.0 0.2 0.3 35.6 3.9 6.8 0.3 0.6 0.7 0.3 4.9 0.0 0.1 0.4 0.1 0.3 0.0 0.7 0.0 0.2 0.7 5.1 0.1 0.0 0.1 39.4 8.2 0.0 0.8 0.0 0.3 0.4 0.0 0.0 0.0 0.9 0.0 0.5 0.1 2.7 21.5 0.0 0.0 0.2 101.4 45.3 6.4 11.5 0.0 0.3 0.7 1.0 0.6 3.6 0.1 0.0 0.5 0.1 29.0 1.7 FUT8 ENSG00000033170 "Fucosyltransferase 8" Q9BYC5 14 65410592-65744121 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Congenital disorder of glycosylation, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 64.3" "Cell type enriched" "Detected in many" 4 "Oligodendrocytes: 1019.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in many" 5 "B-cells: 15.6;NK-cells: 14.8;T-cells: 10.0" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017129, HPA043410" Enhanced Approved "Nucleoplasm,Golgi apparatus,Cytosol" NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 70: Brain - Nervous system development" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Golgi apparatus" "Nucleoplasm, Cytosol" "CAB017129: , HPA043410: AB_2678467" "unprognostic (1.67e-1)" "unprognostic (1.63e-1)" "unprognostic (3.28e-2)" "unprognostic (1.65e-3)" "unprognostic (2.10e-1)" "unprognostic (5.61e-2)" "unprognostic (1.41e-1)" "unprognostic (8.81e-2)" "unprognostic (2.00e-2)" "unprognostic (1.33e-3)" "unprognostic (8.09e-2)" "unprognostic (1.94e-1)" "unprognostic (1.04e-3)" "unprognostic (1.40e-1)" "unprognostic (2.94e-1)" "unprognostic (1.40e-1)" "unprognostic (8.28e-3)" 7.9 8.2 21.0 11.9 38.2 3.6 10.5 44.1 28.2 6.9 0.0 11.4 17.5 9.0 5.3 6.8 15.6 11.1 4.7 20.4 27.7 6.9 3.4 8.1 11.7 32.8 29.9 7.3 9.9 9.6 4.6 17.3 29.3 5.8 11.6 8.3 42.6 10.5 2.5 5.3 17.4 11.0 29.4 10.2 31.8 16.4 29.7 11.3 8.4 6.3 18.6 13.3 4.5 64.3 115.9 22.5 12.6 110.6 49.5 38.4 61.6 35.9 64.8 30.3 32.6 16.9 44.8 30.7 29.2 40.1 79.4 9.0 29.9 11.4 45.6 124.2 11.0 33.5 7.2 23.0 26.8 7.6 23.9 96.0 6.8 39.3 19.4 124.4 69.6 17.1 14.1 28.8 20.8 60.8 36.6 16.7 14.7 59.6 66.6 26.9 10.3 17.2 46.5 33.1 23.4 16.6 20.8 9.8 8.0 70.6 10.2 12.9 141.8 34.5 36.0 15.3 30.5 47.3 18.5 74.3 68.6 13.6 11.1 0.7 2.0 0.7 3.6 0.9 3.8 15.6 6.2 5.6 2.6 8.3 6.6 6.6 0.3 14.8 1.4 2.6 10.0 2.9 21.0 38.2 44.1 28.2 20.4 27.7 32.8 29.9 29.3 29.4 29.7 64.3 19.0 12.8 32.5 227.5 43.1 12.1 7.4 11.5 17.1 10.1 18.3 11.7 5.9 8.6 18.9 12.9 4.2 45.5 8.3 5.9 0.0 9.1 37.9 9.9 14.6 16.0 5.4 15.8 169.0 31.7 28.1 22.7 78.0 10.2 7.6 3.3 14.6 3.5 13.0 8.4 166.4 26.5 2.0 12.2 8.6 15.3 12.8 10.2 1.8 70.3 3.6 27.8 9.2 138.7 1019.1 54.7 10.3 13.5 124.3 8.8 24.5 8.4 15.3 9.1 0.0 14.3 13.2 34.6 26.8 7.4 9.8 14.1 18.9 10.6 21.7 7.2 FUT9 Fuc-TIX ENSG00000172461 "Fucosyltransferase 9" Q9Y231 6 96015974-96215612 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "brain: 18.9;stomach 1: 23.2" "Cell type enhanced" "Detected in some" "Astrocytes: 776.4;Excitatory neurons: 333.5;Inhibitory neurons: 238.2;Oligodendrocyte precursor cells: 168.9;Oligodendrocytes: 224.7" "Cancer enhanced" "Detected in some" "glioma: 1.2" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "MCF7: 2.9;OE19: 2.8;RT4: 6.5;SCLC-21H: 6.3;SK-BR-3: 3.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA070923 Approved "Nucleoplasm,Microtubules,Cytokinetic bridge,Cytosol" Yes No "Cluster 22: Non-specific - Unknown function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 64: Astrocytes - Nervous system maintenance" Nucleoplasm "Microtubules, Cytokinetic bridge, Cytosol" "HPA070923: AB_2686323" "unprognostic (1.60e-1)" "unprognostic (2.48e-1)" "unprognostic (5.99e-3)" "unprognostic (1.33e-1)" "unprognostic (2.40e-1)" "unprognostic (2.97e-1)" "unprognostic (1.35e-1)" "unprognostic (2.85e-1)" "unprognostic (1.45e-1)" "unprognostic (1.12e-1)" "unprognostic (6.43e-3)" "unprognostic (5.60e-2)" "unprognostic (1.65e-2)" "unprognostic (3.03e-2)" 0.0 0.4 10.5 0.0 12.6 0.0 0.6 14.5 11.7 0.0 0.0 0.1 2.1 0.2 0.0 0.0 0.2 0.0 0.0 11.8 13.6 0.2 0.0 0.0 0.0 3.4 18.9 0.0 4.8 0.0 0.4 0.4 3.2 0.2 0.0 0.5 0.0 0.2 0.1 0.1 0.0 0.0 5.5 0.0 23.2 0.0 15.3 0.0 0.1 0.0 0.0 0.9 0.0 6.4 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.9 0.0 0.0 1.4 2.8 0.0 0.0 0.0 0.0 0.0 6.5 6.3 0.1 0.0 3.6 0.0 0.1 0.2 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.5 12.6 14.5 11.7 11.8 13.6 3.4 18.9 3.2 5.5 15.3 6.4 0.0 0.0 0.0 776.4 0.2 0.0 0.6 0.0 0.0 4.2 1.4 1.7 0.8 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.3 0.5 0.1 1.3 0.0 0.0 333.5 2.0 0.0 0.1 56.1 1.4 0.0 0.4 0.0 0.0 0.1 0.0 238.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 28.1 0.0 0.2 0.0 168.9 224.7 0.5 0.0 0.0 0.1 1.1 0.0 0.0 0.0 0.7 0.0 0.0 0.1 0.2 0.2 0.0 0.0 0.3 0.1 0.0 0.0 0.2 FYN "MGC45350, SLK, SYN" ENSG00000010810 "FYN proto-oncogene, Src family tyrosine kinase" P06241 6 111660332-111873452 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Adaptive immunity, Host-virus interaction, Immunity" "Developmental protein, Kinase, Transferase, Tyrosine-protein kinase" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 382.6;dendritic cells: 291.6;NK-cells: 228.6;Oligodendrocyte precursor cells: 342.8;Proximal tubular cells: 212.2;T-cells: 275.8" "Cancer enhanced" "Detected in all" "glioma: 42.5" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in all" 16 "NK-cells: 69.0;T-cells: 174.8" "Cell line enhanced" "Detected in many" "U-2197: 538.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005034, CAB018387, HPA023887, HPA063770" Approved Enhanced "Plasma membrane,Cytosol" NA NA 820000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 18: U-2197 - ECM organization" "Cluster 24: Non-specific - Transcription regulation" "Plasma membrane" Cytosol "CAB005034: AB_562117, CAB018387: AB_627642, HPA023887: AB_1849226, HPA063770: AB_2685119" "unprognostic (8.62e-3)" "unprognostic (8.25e-2)" "unprognostic (2.11e-1)" "unprognostic (2.00e-2)" "unprognostic (1.51e-1)" "unprognostic (2.43e-2)" "prognostic favorable (1.84e-4)" "unprognostic (4.60e-2)" "unprognostic (2.89e-2)" "unprognostic (2.92e-1)" "prognostic favorable (4.78e-4)" "unprognostic (1.43e-1)" "prognostic unfavorable (1.43e-4)" "unprognostic (6.95e-2)" "unprognostic (3.10e-1)" "unprognostic (6.62e-3)" "unprognostic (2.40e-1)" 76.6 10.8 117.1 52.4 106.4 32.3 46.8 83.8 104.3 45.5 33.3 32.9 16.4 45.6 33.8 16.0 51.4 32.1 40.5 102.1 121.5 23.9 20.4 63.5 108.9 136.3 104.9 28.8 8.5 18.7 22.9 29.7 107.0 17.6 15.6 26.9 12.9 12.5 12.3 41.5 47.1 38.0 109.9 71.9 29.3 16.5 105.7 86.1 45.7 18.3 67.6 48.4 33.4 109.8 10.4 1.5 178.6 30.2 133.4 81.4 3.2 29.1 90.8 24.2 42.9 1.3 1.6 21.0 18.3 56.1 21.0 1.3 25.8 39.9 46.8 0.7 66.5 57.0 13.6 2.7 78.7 19.5 19.0 78.8 59.1 90.5 76.8 62.9 99.5 99.6 4.9 140.3 86.8 1.5 92.7 17.9 26.0 3.3 18.0 29.1 24.0 1.4 0.0 9.1 124.6 50.7 5.7 2.4 124.7 39.6 1.3 57.0 63.9 72.3 13.5 538.7 18.5 20.0 19.7 32.5 136.0 44.3 128.9 1.1 6.4 0.2 137.0 5.6 174.8 4.8 83.9 152.7 7.4 6.4 27.9 72.3 3.0 69.0 4.2 4.3 79.2 51.5 117.1 106.4 83.8 104.3 102.1 121.5 136.3 104.9 107.0 109.9 105.7 109.8 87.8 0.0 8.3 382.6 26.0 17.1 2.5 0.6 1.8 57.2 2.9 6.9 11.3 14.3 2.1 7.3 0.0 2.7 291.6 1.2 17.6 9.3 3.7 5.6 51.7 70.3 13.2 20.9 118.7 1.0 2.4 61.9 17.9 4.9 52.0 20.9 76.4 60.3 3.0 47.1 127.6 3.8 2.0 35.8 96.1 3.2 26.4 42.7 37.4 88.1 64.5 89.1 228.6 342.8 162.3 9.7 0.1 7.2 96.2 3.9 17.7 212.2 4.4 8.3 13.1 48.8 32.9 3.9 8.6 0.7 13.4 52.0 275.8 71.1 2.9 1.1 G2E3 "FLJ20333, KIAA1333, PHF7B" ENSG00000092140 "G2/M-phase specific E3 ubiquitin protein ligase" Q7L622 14 30559158-30620064 "Enzymes, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" "Developmental protein, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 42.3" "Group enriched" "Detected in all" 6 "Early spermatids: 722.5;Late spermatids: 233.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001601 Uncertain Approved "Golgi apparatus,Vesicles,Cytosol" NA Yes "Cluster 18: Basophils - Vesicular transport" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 29: Early spermatids - Spermatogenesis" Cytosol "Golgi apparatus, Vesicles" "HPA001601: AB_1079198" "unprognostic (4.75e-2)" "unprognostic (6.31e-2)" "unprognostic (2.27e-2)" "unprognostic (4.86e-2)" "unprognostic (9.10e-2)" "unprognostic (3.99e-2)" "unprognostic (5.44e-6)" "unprognostic (1.17e-2)" "unprognostic (2.81e-2)" "unprognostic (1.86e-1)" "unprognostic (3.13e-2)" "unprognostic (1.35e-1)" "unprognostic (1.00e-1)" "unprognostic (1.67e-1)" "unprognostic (1.23e-1)" "unprognostic (2.32e-2)" "unprognostic (2.12e-2)" 4.8 3.2 2.1 6.4 7.0 10.0 6.4 11.6 5.5 6.4 0.7 5.6 5.0 6.3 3.7 6.2 4.8 3.8 4.8 2.4 5.6 4.5 5.2 4.5 9.1 3.1 2.5 6.1 5.2 5.6 2.7 6.3 2.7 5.1 5.3 13.8 4.9 4.6 3.0 5.9 4.9 6.2 1.0 6.3 5.3 42.3 7.0 14.3 6.6 3.9 8.9 4.9 3.9 9.6 37.9 15.6 33.7 16.1 11.2 15.0 30.5 31.9 12.9 20.2 22.9 17.1 20.5 32.9 10.9 18.4 15.9 29.7 36.4 18.8 42.2 25.7 15.7 19.6 17.1 31.0 10.3 34.0 22.5 8.1 7.4 15.1 34.9 18.3 22.9 22.5 21.2 24.2 29.0 21.9 22.6 9.6 31.2 27.5 32.7 21.4 0.0 8.2 10.5 22.3 28.4 19.9 27.7 16.0 7.9 20.5 19.1 12.5 17.3 19.7 21.9 16.9 21.9 14.1 47.7 38.8 5.4 16.6 29.2 20.2 6.5 12.9 7.6 8.5 10.1 9.2 7.4 6.3 5.6 9.9 9.2 7.8 5.9 6.5 11.3 6.8 6.6 4.1 2.1 7.0 11.6 5.5 2.4 5.6 3.1 2.5 2.7 1.0 7.0 9.6 22.6 19.2 9.0 17.9 32.9 21.9 22.5 11.8 26.7 34.9 13.0 10.8 10.0 12.8 13.6 5.5 25.0 17.8 23.0 9.0 9.8 8.9 722.5 13.9 26.6 17.0 13.8 42.7 45.3 7.1 22.7 20.6 14.3 14.1 17.1 23.3 13.2 7.5 14.2 35.3 38.4 14.7 14.2 13.9 12.4 233.9 16.4 16.5 8.8 24.4 16.2 15.5 32.0 41.7 43.1 10.7 9.4 14.3 14.4 22.5 5.6 12.0 10.9 33.4 52.6 18.0 18.6 69.8 42.7 20.7 25.4 10.0 24.9 11.9 12.4 20.6 GAK DNAJC26 ENSG00000178950 "Cyclin G associated kinase" O14976 4 849276-932373 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 134.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027405, HPA027459, HPA027463" Approved Supported "Golgi apparatus,Vesicles" NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 18: Non-specific - Mitochondria" "Cluster 24: NB-4 - Immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "Golgi apparatus" Vesicles "HPA027405: AB_10611111, HPA027459: AB_10599948, HPA027463: AB_10601959" "unprognostic (1.55e-1)" "unprognostic (1.66e-1)" "unprognostic (2.46e-1)" "unprognostic (3.24e-3)" "unprognostic (1.07e-1)" "unprognostic (3.50e-3)" "unprognostic (1.68e-1)" "unprognostic (7.07e-2)" "unprognostic (1.39e-2)" "unprognostic (3.34e-1)" "unprognostic (3.03e-2)" "unprognostic (3.33e-3)" "prognostic favorable (1.70e-6)" "unprognostic (1.09e-3)" "unprognostic (1.79e-1)" "unprognostic (6.26e-2)" "prognostic favorable (7.41e-4)" 31.9 40.7 21.1 25.9 22.5 35.5 34.0 20.1 29.7 42.7 20.1 56.3 51.2 41.9 8.0 49.7 43.0 17.7 25.4 21.5 17.8 55.0 47.7 46.0 25.6 28.7 19.8 40.5 53.1 22.7 37.1 15.6 22.1 41.8 14.8 9.4 71.0 13.3 31.4 40.4 57.4 9.8 17.7 61.5 54.2 45.8 20.6 21.6 38.5 6.6 12.9 38.7 39.3 20.5 36.0 28.3 16.9 29.0 16.6 14.2 43.6 33.0 19.7 22.3 18.5 35.9 49.8 30.4 20.9 20.1 40.3 29.7 17.7 27.4 10.5 30.7 27.9 35.3 29.5 27.5 31.1 36.2 53.0 20.5 23.2 22.7 11.0 14.2 24.7 35.3 38.4 37.4 15.2 34.7 61.6 92.1 30.4 38.2 46.3 50.2 19.4 27.4 18.2 28.8 29.0 31.3 19.3 24.2 23.3 14.1 39.2 30.7 40.8 30.9 18.0 31.8 45.1 59.5 41.3 33.8 34.9 43.7 29.0 3.0 10.3 12.8 8.8 9.8 7.6 4.9 5.8 6.1 6.5 3.9 3.3 4.8 7.4 4.8 24.6 7.6 5.6 9.4 21.1 22.5 20.1 29.7 21.5 17.8 28.7 19.8 22.1 17.7 20.6 20.5 24.7 25.6 33.2 34.0 33.9 17.0 15.3 17.9 14.8 27.2 25.3 17.7 12.2 18.6 28.2 25.8 64.6 19.0 46.2 131.3 9.8 18.8 99.1 32.2 21.6 26.7 29.4 26.1 25.7 28.0 17.5 19.5 93.8 52.5 18.3 31.2 18.5 31.6 36.6 11.8 23.5 66.5 26.4 35.9 18.4 134.7 25.1 35.5 16.0 59.0 28.8 16.3 35.0 9.0 24.4 37.6 71.1 18.8 26.1 28.4 65.8 31.0 33.8 26.9 19.7 17.9 18.0 32.9 27.4 19.9 22.3 31.1 34.6 41.6 65.0 44.6 GAL3ST1 CST ENSG00000128242 "Galactose-3-O-sulfotransferase 1" Q99999 22 30554635-30574665 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Lipid metabolism, Sphingolipid metabolism" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 51.6;intestine: 24.4;kidney: 18.4" "Cell type enhanced" "Detected in many" "Cholangiocytes: 30.0;Muller glia cells: 35.3;Oligodendrocyte precursor cells: 26.7;Oligodendrocytes: 53.6;Proximal enterocytes: 48.1;Proximal tubular cells: 24.6" "Cancer enriched" "Detected in many" 6 "renal cancer: 38.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 27.6;CACO-2: 7.7;EFO-21: 14.6;K-562: 6.6;OE19: 10.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001220, HPA077138" Approved Uncertain Nucleoplasm,Vesicles "Intracellular and membrane" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 45: Intestine - Brush border" "Cluster 39: CACO-2 - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Vesicles Nucleoplasm "HPA001220: AB_1078933, HPA077138: " "unprognostic (2.69e-2)" "unprognostic (3.12e-4)" "unprognostic (5.93e-2)" "unprognostic (1.08e-2)" "unprognostic (2.32e-1)" "unprognostic (6.50e-3)" "unprognostic (1.53e-2)" "unprognostic (2.23e-1)" "unprognostic (2.89e-1)" "unprognostic (5.18e-2)" "unprognostic (1.19e-1)" "unprognostic (4.43e-2)" "prognostic unfavorable (1.79e-4)" "unprognostic (2.33e-1)" "unprognostic (4.23e-2)" "unprognostic (1.24e-1)" "unprognostic (3.56e-2)" 1.3 0.2 14.8 0.4 33.3 0.8 1.1 27.7 25.8 2.7 0.3 5.2 23.0 2.4 1.7 0.5 3.1 5.2 1.1 14.6 18.3 18.4 4.0 1.9 0.7 32.9 29.0 2.3 6.9 0.7 1.5 0.9 31.0 3.1 2.4 2.3 0.5 1.4 3.1 1.6 24.4 0.3 23.2 0.3 8.2 5.0 29.1 0.1 0.2 0.3 0.0 1.6 1.8 51.6 0.0 27.6 0.5 0.2 0.0 0.0 2.0 0.0 0.2 0.0 0.0 7.7 3.8 0.4 14.6 0.0 0.5 0.1 0.0 0.0 0.0 0.3 0.7 0.4 0.4 5.7 0.6 0.2 0.2 0.2 0.0 0.1 0.2 0.0 0.0 0.4 6.6 0.6 0.0 0.2 0.3 1.1 3.9 10.6 0.4 0.2 0.0 0.7 1.1 0.1 0.3 1.8 0.0 0.4 0.2 0.7 0.2 0.2 0.8 0.2 0.2 0.3 0.0 2.4 1.2 0.3 0.1 0.1 0.2 0.2 0.1 0.0 0.0 0.1 0.1 0.4 0.1 0.1 0.0 0.3 0.1 0.1 0.5 0.0 0.0 0.6 0.0 0.0 14.8 33.3 27.7 25.8 14.6 18.3 32.9 29.0 31.0 23.2 29.1 51.6 0.5 0.0 0.0 2.3 0.3 0.4 0.1 0.0 0.0 0.8 0.6 3.3 0.6 30.0 0.0 3.7 0.0 0.1 0.0 14.0 15.6 7.0 1.1 1.1 0.3 0.3 10.9 2.7 2.0 11.1 0.1 0.3 5.1 2.4 0.0 0.9 0.0 1.6 0.1 0.0 1.9 5.7 0.0 0.3 0.3 0.8 1.5 0.2 0.0 0.0 0.0 35.3 0.0 26.7 53.6 5.0 8.8 2.2 0.1 0.4 48.1 24.6 0.1 1.3 0.0 2.1 0.3 12.4 14.3 0.0 0.3 0.3 0.2 0.0 7.6 0.1 GALK1 GALK ENSG00000108479 "Galactokinase 1" P51570 17 75751594-75765236 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Carbohydrate metabolism, Galactose metabolism" "Kinase, Transferase" "Cataract, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 126.4" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 100.1;Hepatocytes: 116.7;Proximal enterocytes: 139.4;Proximal tubular cells: 122.0" "Cancer enhanced" "Detected in all" "liver cancer: 42.1" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007094, HPA016960" Approved Approved "Golgi apparatus,Cytosol" NA NA 57000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 85: Liver - Metabolism" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Cytosol "Golgi apparatus" "HPA007094: AB_1078939, HPA016960: AB_1849430" "unprognostic (1.16e-1)" "unprognostic (1.33e-2)" "unprognostic (1.81e-2)" "unprognostic (2.94e-2)" "unprognostic (1.00e-1)" "unprognostic (2.21e-1)" "unprognostic (1.29e-1)" "unprognostic (7.82e-2)" "unprognostic (2.26e-1)" "unprognostic (7.04e-2)" "unprognostic (1.06e-1)" "unprognostic (2.35e-2)" "prognostic unfavorable (1.55e-6)" "unprognostic (3.04e-1)" "unprognostic (1.71e-1)" "unprognostic (2.77e-1)" "prognostic unfavorable (1.62e-5)" 18.6 12.5 5.9 7.8 6.7 5.6 17.1 6.4 8.4 17.5 5.9 12.5 20.6 16.5 1.0 24.4 14.9 4.3 19.7 6.0 6.6 32.0 126.4 18.7 7.4 7.9 6.3 13.7 31.2 10.6 5.7 5.8 7.5 13.3 2.0 0.7 20.0 5.7 8.6 20.6 18.3 3.9 7.0 24.5 17.6 16.0 6.8 6.1 11.6 3.6 3.4 13.0 17.8 8.2 20.4 65.2 4.9 20.7 6.8 16.6 16.7 16.9 14.3 16.8 15.8 35.4 4.2 31.2 19.5 9.3 12.6 11.9 5.0 4.4 1.9 14.2 39.3 20.1 25.1 62.4 22.1 13.0 41.9 15.3 6.9 8.5 3.5 8.5 39.1 16.9 15.9 21.2 11.7 77.3 38.6 44.7 4.7 9.8 32.3 43.6 50.1 50.9 9.8 7.3 9.9 26.1 14.6 35.8 35.0 3.8 29.8 20.9 33.4 24.3 22.3 21.7 14.6 44.4 12.4 8.2 26.7 30.3 18.3 7.2 77.2 23.0 23.0 67.8 20.8 27.7 18.5 21.2 70.1 18.9 10.0 14.5 53.1 16.2 55.6 93.3 23.6 40.8 5.9 6.7 6.4 8.4 6.0 6.6 7.9 6.3 7.5 7.0 6.8 8.2 42.1 16.0 12.9 3.3 17.7 8.7 10.0 4.4 7.4 7.3 22.4 20.6 22.6 22.8 10.6 12.9 0.0 48.4 16.3 8.4 68.4 28.5 1.3 4.9 24.5 23.5 8.4 9.0 1.5 55.2 100.1 25.3 10.2 8.6 27.9 16.6 29.3 116.7 56.1 3.3 1.7 20.9 22.4 49.0 25.2 5.6 31.1 33.3 39.2 0.0 42.3 19.2 20.6 2.5 1.6 19.3 49.6 24.0 29.1 5.7 139.4 122.0 4.0 6.1 6.6 19.2 20.8 1.7 22.1 16.6 12.5 42.3 14.9 6.1 28.2 9.2 GALK2 GK2 ENSG00000156958 "Galactokinase 2" Q01415 15 49155656-49367869 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 92.2;Inhibitory neurons: 90.1;Oligodendrocytes: 109.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA043564, HPA048267" Uncertain Approved Nucleoplasm,Cytosol NA NA 24000 "Cluster 44: Non-specific - Transcription" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 16: U-266 - Nucleosome" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Nucleoplasm, Cytosol" "HPA043564: AB_2678557, HPA048267: AB_2680335" "unprognostic (2.27e-2)" "unprognostic (1.45e-1)" "unprognostic (2.38e-1)" "prognostic favorable (7.31e-4)" "unprognostic (3.04e-1)" "unprognostic (9.78e-2)" "unprognostic (2.66e-1)" "unprognostic (1.95e-1)" "unprognostic (2.30e-1)" "unprognostic (8.67e-3)" "unprognostic (2.25e-2)" "unprognostic (2.43e-1)" "prognostic favorable (1.88e-5)" "unprognostic (2.33e-1)" "unprognostic (9.79e-2)" "unprognostic (2.13e-2)" "unprognostic (1.93e-1)" 10.3 16.8 8.5 8.5 9.3 6.6 11.2 10.1 9.3 12.5 14.8 15.2 20.2 8.5 8.7 8.1 12.2 8.9 12.8 8.7 8.5 30.4 21.1 10.5 8.3 8.6 9.0 9.3 12.2 17.5 9.6 9.9 9.0 9.7 16.2 7.7 9.9 10.9 10.5 9.0 16.6 10.7 8.5 8.9 13.2 7.0 8.3 12.6 14.8 16.9 10.0 9.3 8.5 11.4 14.7 17.1 7.5 10.1 19.1 29.7 21.9 14.7 20.2 14.7 17.2 21.6 15.0 4.8 11.6 15.9 18.0 20.5 30.2 21.6 20.6 26.2 9.1 26.8 15.7 18.4 20.9 19.2 8.2 15.4 38.4 15.7 37.4 16.8 30.2 11.0 27.4 25.5 16.1 15.9 13.9 15.3 3.3 44.0 15.9 16.7 9.5 71.0 27.3 13.8 9.1 6.0 16.6 33.3 29.6 15.0 16.9 18.3 16.6 14.1 9.6 58.4 14.3 20.9 76.2 8.9 22.2 70.1 19.8 45.4 15.3 28.4 18.1 16.7 18.9 14.0 18.0 17.3 15.2 11.1 14.2 14.3 7.6 19.6 17.2 13.3 35.3 13.1 8.5 9.3 10.1 9.3 8.7 8.5 8.6 9.0 9.0 8.5 8.3 11.4 13.6 3.2 14.9 48.6 12.7 5.6 13.6 16.8 9.1 13.3 12.1 10.3 3.1 27.1 14.5 5.5 37.5 14.8 10.6 14.5 29.4 20.0 12.0 19.2 15.7 12.0 9.0 12.0 92.2 13.1 29.0 12.7 18.3 12.0 2.5 9.8 22.9 25.7 20.4 15.2 90.1 25.1 20.3 16.8 5.7 4.8 11.5 12.6 14.2 63.7 16.5 11.6 20.6 41.7 109.5 10.7 16.2 11.3 27.9 8.3 30.5 56.5 34.1 25.8 0.0 13.4 11.6 22.3 5.9 9.0 6.3 25.7 13.9 13.8 19.0 9.7 GALNT1 GalNAc-T1 ENSG00000141429 "Polypeptide N-acetylgalactosaminyltransferase 1" Q10472 18 35581117-35711834 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HUVEC TERT2: 331.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA012628 Uncertain "Intracellular and membrane" NA NA 2600000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 37: Intestine - Unknown function" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA012628: AB_1849439" "unprognostic (9.81e-2)" "unprognostic (1.01e-1)" "unprognostic (4.39e-2)" "unprognostic (2.73e-1)" "unprognostic (2.08e-1)" "unprognostic (2.83e-2)" "unprognostic (1.96e-2)" "unprognostic (7.06e-2)" "unprognostic (2.03e-2)" "unprognostic (1.51e-2)" "unprognostic (3.00e-2)" "unprognostic (1.00e-1)" "unprognostic (3.47e-2)" "unprognostic (4.38e-2)" "unprognostic (2.74e-2)" "unprognostic (1.07e-2)" "unprognostic (8.60e-2)" 28.9 20.6 11.9 27.4 12.1 26.0 37.2 12.3 14.2 26.5 15.1 42.8 42.9 19.4 19.7 57.6 15.9 28.9 23.8 10.9 14.4 17.4 45.9 23.3 33.5 13.1 13.2 16.9 24.6 12.2 13.5 52.0 13.5 25.4 41.1 17.1 46.8 18.0 29.0 52.4 49.3 22.7 13.1 25.4 27.1 16.9 13.1 18.6 30.0 37.3 40.8 70.5 27.0 13.9 32.5 34.9 40.5 37.6 78.5 74.0 53.4 33.2 35.4 30.3 27.4 21.0 61.9 38.3 34.9 36.0 28.7 24.4 20.2 63.8 48.1 45.0 18.5 48.7 62.8 48.8 39.2 106.6 62.1 50.7 59.7 47.6 52.1 90.1 331.4 30.8 14.8 49.3 118.9 26.1 31.6 40.5 41.6 33.5 16.4 38.9 53.0 18.5 124.8 148.9 21.8 42.9 59.4 43.0 36.2 77.1 32.9 82.8 116.3 55.7 22.5 37.0 37.1 70.1 35.7 72.5 39.1 72.1 29.5 7.2 3.4 7.6 3.2 4.5 3.6 4.1 2.2 2.9 4.0 2.4 2.0 3.0 4.3 4.6 6.6 4.4 2.5 1.4 11.9 12.1 12.3 14.2 10.9 14.4 13.1 13.2 13.5 13.1 13.1 13.9 85.6 80.1 44.1 35.9 33.4 29.8 28.4 28.8 22.2 31.3 77.2 43.8 43.3 48.6 39.9 16.5 12.5 31.0 44.8 109.1 7.9 42.6 1.4 77.6 44.7 41.7 38.9 30.9 57.5 39.9 92.7 49.8 26.0 73.0 20.3 51.7 35.7 71.3 77.9 85.8 56.3 59.0 16.2 58.8 37.1 2.9 19.0 56.7 19.6 57.1 41.3 105.9 28.8 54.3 56.8 58.5 51.4 18.0 36.7 54.4 76.8 22.0 33.5 28.5 13.1 55.2 28.7 6.5 12.2 26.3 82.1 33.2 33.7 50.3 85.3 52.8 GALNT10 GalNAc-T10 ENSG00000164574 "Polypeptide N-acetylgalactosaminyltransferase 10" Q86SR1 5 154190730-154420984 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "ovary: 65.8" "Cell type enhanced" "Detected in many" "Microglial cells: 74.0;Oligodendrocyte precursor cells: 156.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "hTERT-RPE1: 284.9;TIME: 161.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007525 Approved Approved "Nucleoplasm,Golgi apparatus,Plasma membrane" "Intracellular and membrane" NA NA 1100000 "Cluster 41: Basophils - Cellular respiration" "Cluster 89: Fibroblasts - ECM organization" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 68: Oligodendrocytes - Mixed function" "Plasma membrane" "Nucleoplasm, Golgi apparatus" "HPA007525: AB_1849443" "unprognostic (6.99e-2)" "unprognostic (4.33e-2)" "unprognostic (9.85e-2)" "prognostic favorable (3.33e-6)" "unprognostic (1.63e-1)" "unprognostic (6.98e-2)" "unprognostic (6.95e-3)" "unprognostic (2.38e-1)" "unprognostic (3.34e-1)" "prognostic unfavorable (5.69e-4)" "unprognostic (2.88e-3)" "unprognostic (2.63e-1)" "unprognostic (1.54e-1)" "unprognostic (7.76e-3)" "unprognostic (1.22e-1)" "unprognostic (1.61e-2)" "unprognostic (3.08e-1)" 12.1 15.6 10.7 14.4 14.5 19.3 13.5 12.1 10.0 24.1 33.0 16.1 14.4 6.3 6.0 4.9 14.6 16.7 9.0 9.5 12.5 9.7 4.4 15.5 9.9 16.1 13.9 65.8 9.8 13.6 11.5 4.7 12.3 9.1 14.7 7.8 13.5 3.7 5.4 6.0 12.6 11.6 9.9 15.8 22.0 4.5 13.9 7.8 16.6 8.2 9.4 11.1 5.2 12.6 25.6 85.3 20.3 17.8 42.2 37.3 15.6 71.7 39.9 27.9 26.7 12.1 56.7 16.6 49.3 121.4 49.9 4.4 9.4 56.0 25.4 43.2 6.7 45.4 16.0 16.5 32.4 9.9 42.3 46.7 12.9 22.7 33.2 284.9 54.4 12.5 10.5 50.9 48.4 26.4 1.1 6.8 8.0 71.1 17.3 5.1 10.7 16.6 38.6 17.1 2.7 6.6 31.8 117.0 9.4 29.6 45.6 7.4 161.2 67.5 15.9 16.8 77.7 14.5 15.0 8.7 44.2 19.3 21.1 2.0 1.2 2.4 3.1 1.6 2.8 1.9 1.8 2.0 1.4 2.1 0.8 2.1 2.5 1.9 1.8 1.1 1.6 1.0 10.7 14.5 12.1 10.0 9.5 12.5 16.1 13.9 12.3 9.9 13.9 12.6 17.4 9.6 46.4 32.7 17.4 4.8 3.9 5.6 1.8 4.6 12.4 8.6 5.0 5.7 8.7 14.7 4.2 0.7 27.7 23.0 9.8 9.1 10.3 12.4 7.4 14.1 3.0 21.4 14.3 30.1 1.5 13.7 30.5 22.3 10.2 10.5 23.9 5.3 8.5 0.0 15.9 20.4 6.1 19.5 7.8 22.5 38.2 12.4 0.0 74.0 11.9 17.4 44.3 156.9 66.9 36.8 13.6 50.0 15.4 8.2 15.3 2.7 0.7 10.5 6.6 5.6 7.8 2.0 4.0 1.2 3.7 0.8 21.7 27.3 12.2 4.2 GALNT11 GalNAc-T11 ENSG00000178234 "Polypeptide N-acetylgalactosaminyltransferase 11" Q8NCW6 7 152025674-152122340 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Notch signaling pathway" "Glycosyltransferase, Transferase" Heterotaxy "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "choroid plexus: 408.0;kidney: 229.5" "Cell type enhanced" "Detected in many" "Excitatory neurons: 131.1;Inhibitory neurons: 130.7;Proximal tubular cells: 196.7" "Cancer enhanced" "Detected in all" "renal cancer: 30.9" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039330 Uncertain NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA039330: AB_10795249" "unprognostic (6.09e-2)" "unprognostic (1.22e-1)" "unprognostic (4.98e-2)" "unprognostic (3.48e-2)" "prognostic unfavorable (9.54e-4)" "unprognostic (1.76e-1)" "unprognostic (9.10e-3)" "unprognostic (1.56e-3)" "unprognostic (1.38e-1)" "unprognostic (3.65e-1)" "unprognostic (3.82e-2)" "unprognostic (1.64e-1)" "prognostic favorable (2.24e-6)" "unprognostic (1.33e-1)" "unprognostic (1.17e-1)" "unprognostic (2.97e-1)" "unprognostic (9.51e-2)" 32.4 25.4 27.9 15.2 30.7 12.7 29.0 24.1 29.3 23.7 408.0 21.9 14.5 23.8 24.6 26.3 22.4 26.1 26.4 39.1 25.1 229.5 19.9 27.5 16.1 20.8 23.9 28.1 84.1 58.0 24.4 45.8 21.6 32.3 17.6 40.6 22.8 25.6 28.4 23.8 15.0 24.2 16.9 20.5 22.0 11.8 30.3 23.8 34.4 26.0 17.8 24.2 24.0 27.0 28.9 25.4 36.8 41.2 83.1 81.3 37.7 22.6 25.6 18.6 17.4 20.7 29.7 0.1 57.8 36.8 51.8 13.3 17.6 31.9 22.8 23.5 26.3 5.8 23.4 18.2 27.3 26.2 29.3 72.1 40.3 15.5 13.0 32.3 34.1 19.9 29.5 0.2 47.0 24.9 22.7 23.6 30.4 45.1 20.2 0.1 16.1 0.9 61.1 43.8 32.6 43.3 37.5 18.0 31.0 39.0 26.8 22.3 31.1 24.8 8.8 31.6 25.1 8.4 11.4 0.5 51.6 25.1 86.6 10.2 12.7 13.5 28.1 15.2 27.8 9.5 15.4 25.8 13.0 5.7 13.1 19.9 6.6 26.2 21.3 4.0 12.7 14.4 27.9 30.7 24.1 29.3 39.1 25.1 20.8 23.9 21.6 16.9 30.3 27.0 28.7 12.8 25.2 44.4 12.9 10.5 24.6 20.5 13.1 123.9 23.5 20.7 30.7 15.7 16.1 35.0 27.1 84.0 49.1 8.7 60.7 17.8 4.8 31.5 38.8 22.8 22.8 7.8 131.1 18.7 13.5 33.8 11.7 57.1 14.5 26.0 22.1 15.8 25.3 75.7 130.7 10.0 8.2 19.7 12.5 3.5 19.9 21.7 17.8 46.9 18.0 37.8 43.3 54.3 42.0 13.0 8.3 36.1 20.3 26.3 9.6 196.7 21.2 39.4 0.0 36.3 25.0 38.7 27.5 24.7 11.8 36.3 29.1 24.3 9.3 19.1 GALNT12 GalNAc-T12 ENSG00000119514 "Polypeptide N-acetylgalactosaminyltransferase 12" Q8IXK2 9 98807670-98850081 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "epididymis: 74.7;intestine: 55.8;stomach 1: 54.8" "Cell type enhanced" "Detected in many" "Distal enterocytes: 101.2;Intestinal goblet cells: 142.4;Undifferentiated cells: 42.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "OE19: 128.4;U-2197: 160.9" "Low region specificity" "Detected in some" "Low region specificity" "Detected in many" "HPA048292, HPA071076" Enhanced Approved "Nucleoplasm,Plasma membrane,Cell Junctions" "Intracellular and membrane" NA NA 47000 "Cluster 48: NK-cells - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 18: U-2197 - ECM organization" "Cluster 27: Mucus-secreting cells - Mucin production" "Plasma membrane" "Nucleoplasm, Cell Junctions" "HPA048292: AB_2680343, HPA071076: " "unprognostic (7.85e-3)" "unprognostic (1.50e-1)" "unprognostic (2.33e-1)" "unprognostic (1.47e-2)" "unprognostic (2.97e-3)" "unprognostic (4.10e-2)" "unprognostic (1.06e-1)" "unprognostic (1.03e-1)" "unprognostic (2.03e-2)" "unprognostic (1.97e-1)" "unprognostic (2.61e-2)" "unprognostic (7.71e-2)" "prognostic favorable (3.24e-4)" "unprognostic (9.05e-2)" "unprognostic (1.92e-1)" "unprognostic (1.60e-3)" "unprognostic (6.87e-2)" 5.0 2.0 1.2 7.7 1.3 2.2 3.4 6.5 1.8 8.7 4.3 55.3 34.2 3.7 74.7 19.6 7.5 10.5 1.2 1.1 1.4 4.8 0.4 11.7 3.2 2.6 1.4 0.4 13.6 6.3 3.4 2.6 2.7 4.6 55.8 0.6 25.5 4.3 1.3 3.4 27.1 14.0 1.1 2.2 54.8 4.6 1.5 3.3 14.7 0.6 6.1 11.9 4.6 1.6 5.4 4.1 3.4 13.5 10.0 7.8 0.0 1.4 2.1 2.0 4.6 0.8 21.6 0.0 5.0 0.9 12.2 38.0 2.9 1.3 1.6 26.2 1.7 2.4 0.2 0.0 0.5 1.6 0.5 3.8 0.9 6.4 0.0 2.7 2.3 19.3 30.2 0.0 0.6 13.9 2.6 4.7 16.7 128.4 5.6 6.5 0.3 0.1 2.3 7.7 12.4 1.1 0.5 30.6 3.0 7.7 4.5 4.5 4.3 0.0 0.3 160.9 0.0 2.1 4.8 2.3 37.1 0.0 0.9 0.0 0.0 0.5 0.3 0.0 0.6 0.0 0.4 0.2 0.0 0.1 0.6 0.3 0.0 0.6 0.0 0.1 0.0 0.1 1.2 1.3 6.5 1.8 1.1 1.4 2.6 1.4 2.7 1.1 1.5 1.6 1.3 3.2 25.7 2.0 2.3 2.4 1.3 8.3 1.2 2.4 0.4 0.1 1.0 18.6 16.9 11.0 16.7 1.0 2.6 101.2 0.0 11.2 1.8 4.8 1.6 1.6 19.9 1.3 7.4 25.4 1.7 12.5 32.1 8.7 2.5 2.4 0.0 0.0 2.3 0.0 5.7 142.4 2.0 0.3 3.9 1.4 2.1 3.9 0.0 3.7 0.2 0.8 3.1 3.5 7.0 32.0 36.5 7.5 1.7 7.4 21.9 2.7 16.9 0.2 0.0 0.7 1.5 5.9 10.5 9.9 1.3 1.1 4.5 5.1 42.5 11.1 GALNT13 "GalNAc-T13, KIAA1918" ENSG00000144278 "Polypeptide N-acetylgalactosaminyltransferase 13" Q8IUC8 2 153871922-154453979 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 30.1;retina: 9.9" "Cell type enhanced" "Detected in some" "Excitatory neurons: 214.6;Inhibitory neurons: 333.1;Oligodendrocyte precursor cells: 986.7;Oligodendrocytes: 398.2" "Cancer enriched" "Detected in some" 5 "glioma: 4.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "SH-SY5Y: 43.8;U-251 MG: 12.0;WM-115: 33.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA060775 Approved NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA060775: AB_2684358" "unprognostic (1.97e-1)" "unprognostic (3.43e-3)" "unprognostic (2.47e-2)" "unprognostic (1.00e-3)" "unprognostic (4.21e-3)" "unprognostic (7.73e-3)" "unprognostic (6.50e-2)" "unprognostic (8.17e-2)" "unprognostic (3.57e-1)" "unprognostic (9.15e-2)" "unprognostic (3.83e-2)" "unprognostic (3.09e-2)" "unprognostic (5.17e-2)" "unprognostic (2.05e-5)" "unprognostic (8.61e-3)" "unprognostic (1.52e-1)" "unprognostic (2.05e-1)" 2.1 5.0 8.4 0.2 9.9 0.1 1.2 30.1 7.7 1.7 1.0 0.4 0.2 1.8 1.2 0.1 0.4 0.5 0.2 7.6 17.9 0.1 0.0 2.1 0.0 9.3 12.3 0.5 0.3 0.0 1.7 0.4 11.4 2.0 0.3 9.9 4.1 1.4 1.0 0.6 0.3 1.0 9.5 0.0 0.4 0.6 10.8 0.0 0.0 0.0 0.0 0.7 0.2 11.4 0.0 5.2 2.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 2.7 0.1 5.5 0.0 0.0 0.1 2.8 0.0 5.0 1.8 0.0 0.0 0.0 0.1 0.2 0.0 0.0 8.6 0.0 0.1 0.1 0.5 1.0 0.0 0.0 0.2 7.3 0.2 6.9 0.0 0.3 1.0 0.0 0.0 7.5 43.8 0.1 0.1 0.0 0.7 0.0 0.1 0.0 0.1 1.9 0.1 12.0 0.6 0.1 0.0 7.2 0.0 33.5 0.0 0.1 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 8.4 9.9 30.1 7.7 7.6 17.9 9.3 12.3 11.4 9.5 10.8 11.4 0.2 25.6 1.1 13.1 0.0 0.1 0.0 0.0 0.0 14.4 0.2 0.3 1.0 0.0 1.3 0.0 52.1 0.1 0.0 0.1 0.0 0.0 1.9 0.4 21.5 0.7 3.5 0.0 214.6 0.2 0.0 2.8 0.0 0.3 0.0 0.1 0.0 0.0 0.1 72.3 333.1 1.3 0.0 0.0 0.0 1.1 0.0 0.1 0.0 2.8 0.0 0.9 0.0 986.7 398.2 0.3 0.0 0.0 0.0 0.0 0.4 0.2 0.0 1.6 0.0 0.2 0.5 0.8 0.6 0.0 0.1 0.0 0.2 4.2 0.9 0.0 GALNT14 "FLJ12691, GalNac-T10, GalNac-T14" ENSG00000158089 "Polypeptide N-acetylgalactosaminyltransferase 14" Q96FL9 2 30910467-31155202 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "kidney: 41.3" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 21.6;Excitatory neurons: 29.1;Inhibitory neurons: 79.2;Proximal enterocytes: 21.9;Proximal tubular cells: 45.5" "Cancer enriched" "Detected in many" 7 "renal cancer: 45.9" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in some" 8 "neutrophil: 8.5" "Lineage enriched" "Detected in many" 8 "granulocytes: 8.5" "Cell line enhanced" "Detected in many" "A549: 28.6;RPMI-8226: 32.3;RPTEC TERT1: 41.3;RT4: 35.3;SCLC-21H: 24.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA030138 Approved "Nucleoplasm,Golgi apparatus" NA NA 27000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 7: Kidney - Transmembrane transport" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Golgi apparatus" Nucleoplasm "HPA030138: AB_2673332" "unprognostic (5.69e-2)" "unprognostic (1.35e-1)" "unprognostic (2.05e-2)" "unprognostic (2.82e-3)" "unprognostic (3.85e-2)" "unprognostic (2.10e-2)" "unprognostic (3.32e-1)" "unprognostic (7.58e-2)" "unprognostic (1.96e-1)" "unprognostic (2.80e-1)" "unprognostic (1.22e-3)" "unprognostic (1.12e-1)" "unprognostic (3.18e-3)" "unprognostic (5.18e-3)" "unprognostic (2.67e-2)" "unprognostic (2.56e-1)" "unprognostic (9.51e-3)" 1.2 1.5 3.9 1.0 10.6 5.9 0.8 2.0 4.5 1.3 3.6 0.3 0.5 0.3 0.3 11.8 1.2 2.2 0.3 2.9 3.2 41.3 1.3 0.6 2.2 1.7 6.7 0.1 3.1 4.0 5.9 0.0 0.8 1.6 0.1 0.6 1.2 0.0 0.1 2.1 3.3 0.7 1.8 2.4 0.5 2.5 10.9 0.4 0.9 0.4 4.8 2.3 1.3 3.3 23.6 28.6 0.0 0.0 0.0 0.0 0.0 7.9 4.1 4.9 0.6 0.0 0.0 22.1 7.8 0.4 0.0 0.0 1.0 1.0 0.8 0.6 2.8 12.1 0.0 0.0 0.0 18.2 0.0 0.1 4.5 0.0 17.0 0.2 0.0 0.6 0.0 19.0 0.0 10.7 0.1 0.0 12.6 0.0 0.0 15.5 0.0 32.3 41.3 35.3 24.4 18.3 0.0 0.0 0.1 4.4 0.1 0.0 0.0 0.0 19.6 0.0 0.5 1.9 6.2 0.1 0.0 11.1 0.8 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 8.5 0.0 0.0 0.0 0.0 0.0 3.9 10.6 2.0 4.5 2.9 3.2 1.7 6.7 0.8 1.8 10.9 3.3 2.2 0.0 0.0 1.0 1.4 2.8 4.1 5.3 21.6 0.3 0.6 2.4 1.1 0.0 6.2 9.2 0.0 0.0 0.0 0.3 13.7 2.9 5.7 0.0 0.1 1.2 0.0 0.0 29.1 0.4 0.0 1.1 0.5 0.4 0.0 0.0 8.2 0.2 0.1 0.0 79.2 0.9 2.0 0.6 0.3 12.0 0.0 0.4 0.0 2.8 0.0 0.2 0.0 4.0 8.7 2.6 0.0 0.0 3.1 14.2 21.9 45.5 1.1 0.4 6.6 0.4 2.2 3.4 6.9 9.2 0.9 0.0 0.4 0.2 1.8 5.1 GALNT15 "GALNT7, GALNTL2, pp-GalNAc-T15" ENSG00000131386 "Polypeptide N-acetylgalactosaminyltransferase 15" Q8N3T1 3 16174680-16231992 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adipose tissue: 157.4;brain: 141.7" "Cell type enhanced" "Detected in many" "Adipocytes: 103.9;Astrocytes: 34.6;Early spermatids: 26.6;Endothelial cells: 26.9;Hepatic stellate cells: 41.7;Muller glia cells: 47.4;Oligodendrocytes: 69.3" "Cancer enriched" "Detected in many" 5 "glioma: 21.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in many" 5 "ASC diff: 133.0;ASC TERT1: 128.8;HSkMC: 102.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA017076 Uncertain Approved "Golgi apparatus,Cytosol" "Intracellular and membrane" NA NA 40000 "Cluster 15: NK-cells - Transcription" "Cluster 57: Non-specific - Angiogenesis" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "Golgi apparatus" Cytosol "HPA017076: AB_1849458" "unprognostic (3.87e-1)" "unprognostic (4.84e-4)" "unprognostic (6.39e-2)" "unprognostic (8.77e-3)" "unprognostic (2.77e-1)" "unprognostic (2.52e-1)" "unprognostic (7.40e-4)" "unprognostic (4.24e-1)" "unprognostic (2.24e-1)" "unprognostic (8.28e-6)" "unprognostic (5.13e-2)" "unprognostic (2.58e-1)" "unprognostic (2.66e-2)" "unprognostic (1.37e-3)" "unprognostic (1.88e-1)" "unprognostic (8.51e-2)" "unprognostic (1.78e-3)" 157.4 4.9 45.1 1.7 55.8 2.7 87.2 62.5 49.3 12.3 14.4 21.7 3.0 11.4 11.9 12.4 24.9 5.6 18.1 47.9 90.8 11.8 4.0 9.4 4.1 137.6 60.4 22.3 3.6 2.4 3.5 32.3 130.8 6.0 3.9 13.4 25.5 4.7 36.3 41.7 21.2 7.0 102.4 12.3 15.3 9.1 62.8 4.0 18.3 35.3 1.3 33.0 22.8 141.7 0.4 1.3 0.9 1.0 133.0 128.8 0.3 3.4 2.5 0.4 1.3 0.0 0.5 0.5 1.9 7.8 2.3 0.8 0.5 1.4 2.0 0.6 1.4 1.1 1.9 0.0 7.4 1.5 0.4 102.8 0.0 1.2 1.8 2.4 2.8 0.7 0.2 3.0 1.1 1.9 0.0 2.1 0.5 0.8 1.1 0.3 1.1 24.1 0.5 0.5 0.4 0.3 0.4 1.0 0.6 0.6 0.7 1.8 3.9 0.6 4.3 26.8 0.6 1.4 5.1 1.4 2.5 0.4 0.4 0.5 0.1 0.0 0.2 0.1 0.1 0.1 0.1 0.1 0.0 0.2 0.1 0.2 0.1 0.2 0.1 0.3 0.1 0.0 45.1 55.8 62.5 49.3 47.9 90.8 137.6 60.4 130.8 102.4 62.8 141.7 103.9 0.0 1.7 34.6 0.1 0.5 0.4 0.0 0.0 3.8 1.1 0.9 2.8 0.0 0.6 0.0 0.0 0.0 0.3 0.0 0.0 0.1 26.6 0.5 3.3 26.9 0.0 0.0 4.9 0.0 0.1 24.7 0.0 1.0 1.3 0.1 41.7 1.8 0.1 0.0 3.9 0.0 0.0 0.8 2.1 16.7 1.8 0.5 0.0 22.5 0.1 47.4 0.0 5.0 69.3 0.2 0.0 0.7 1.8 2.1 0.0 0.1 0.0 3.2 0.0 7.3 2.1 25.5 0.5 0.1 0.9 0.0 0.2 0.3 0.0 0.3 GALNT16 "GalNAc-T16, GALNTL1, KIAA1130" ENSG00000100626 "Polypeptide N-acetylgalactosaminyltransferase 16" Q8N428 14 69259277-69357033 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 40.8;heart muscle: 45.0" "Cell type enhanced" "Detected in many" "Astrocytes: 16.6;Cardiomyocytes: 46.7;Excitatory neurons: 27.6;Fibroblasts: 24.0;Inhibitory neurons: 23.8;Smooth muscle cells: 14.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 8.5;ASC diff: 11.7;hTEC/SVTERT24-B: 17.0;hTERT-RPE1: 17.2;SCLC-21H: 8.7;U-2 OS: 19.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA059136, HPA075325" Approved Approved Vesicles,Cytosol NA NA 370000 "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "Vesicles, Cytosol" "HPA059136: AB_2683919, HPA075325: " "unprognostic (9.71e-3)" "unprognostic (7.47e-2)" "unprognostic (4.02e-1)" "unprognostic (2.30e-2)" "unprognostic (6.71e-2)" "unprognostic (5.72e-3)" "unprognostic (3.18e-3)" "unprognostic (1.22e-1)" "unprognostic (1.02e-1)" "unprognostic (1.28e-2)" "unprognostic (3.62e-4)" "unprognostic (1.31e-2)" "prognostic favorable (5.23e-6)" "unprognostic (5.38e-3)" "unprognostic (3.34e-2)" "unprognostic (3.93e-2)" "unprognostic (7.96e-5)" 14.4 11.6 25.7 2.0 24.4 0.1 12.0 14.7 28.4 7.6 6.5 6.5 2.2 7.3 2.8 3.6 5.6 3.4 45.0 27.0 35.5 7.7 2.0 3.4 3.2 19.6 22.5 2.1 4.3 2.5 4.7 0.4 19.9 4.0 2.2 1.3 23.5 4.6 4.4 7.5 3.7 8.6 16.4 12.1 3.2 3.5 40.8 2.2 4.9 5.8 1.3 3.1 5.0 21.3 0.0 0.8 8.5 0.3 11.7 5.3 0.0 1.3 0.1 1.5 2.3 0.4 0.0 0.0 0.2 1.4 0.8 0.0 3.0 0.0 0.3 0.1 6.0 0.0 0.2 0.5 0.1 0.0 0.5 0.5 0.0 17.0 0.0 17.2 0.9 0.0 0.0 0.0 2.8 0.5 0.0 0.0 1.7 0.0 0.1 0.0 4.8 0.0 0.5 0.0 8.7 3.0 1.8 0.4 0.0 0.3 0.3 0.0 0.1 1.7 19.9 2.2 2.0 0.0 0.0 0.0 1.6 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 25.7 24.4 14.7 28.4 27.0 35.5 19.6 22.5 19.9 16.4 40.8 21.3 4.0 0.0 0.0 16.6 0.0 4.1 0.4 0.0 0.0 2.8 3.1 3.0 46.7 0.0 0.0 0.0 2.1 0.1 0.2 0.0 3.9 0.1 9.7 0.2 0.4 1.7 0.0 0.0 27.6 0.0 0.0 24.0 0.5 0.2 0.0 0.3 0.0 0.0 0.2 0.0 23.8 0.1 0.0 0.0 6.1 11.2 0.9 0.3 3.6 5.6 0.0 0.1 0.0 8.0 1.6 0.0 0.0 3.8 0.0 0.5 0.1 0.1 0.0 0.8 6.6 10.1 14.8 0.6 2.1 0.3 3.3 0.0 0.3 11.2 0.6 0.4 GALNT17 "GalNAc-T17, GalNAc-T19, GalNAc-T5L, GALNTL3, ppGalNAc-T17, WBSCR17" ENSG00000185274 "Polypeptide N-acetylgalactosaminyltransferase 17" Q6IS24 7 71132144-71713600 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Williams-Beuren syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 55.0;choroid plexus: 46.0;heart muscle: 43.5" "Cell type enhanced" "Detected in some" "Collecting duct cells: 1.8;Endometrial stromal cells: 7.4;Fibroblasts: 1.5;Granulosa cells: 1.7;Theca cells: 2.3" "Cancer enhanced" "Detected in many" "prostate cancer: 8.0" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 14.3;NTERA-2: 10.8;RPMI-8226: 12.6;SK-BR-3: 45.7;SuSa: 14.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA013624, HPA047986" Approved Uncertain "Nucleoplasm,Nucleoli,Nuclear bodies,Golgi apparatus" NA NA "Cluster 35: Non-specific - Unknown function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 36: Stromal cells - Cell proliferation" "Nucleoplasm, Golgi apparatus" "Nucleoli, Nuclear bodies" "HPA013624: AB_1858787, HPA047986: " "unprognostic (2.79e-2)" "unprognostic (6.83e-2)" "unprognostic (5.54e-2)" "unprognostic (3.66e-3)" "unprognostic (1.50e-1)" "unprognostic (2.62e-1)" "unprognostic (6.41e-2)" "unprognostic (5.18e-2)" "unprognostic (1.00e-1)" "prognostic favorable (4.60e-4)" "unprognostic (2.00e-1)" "unprognostic (4.73e-1)" "unprognostic (1.96e-2)" "unprognostic (9.63e-3)" "prognostic favorable (3.91e-4)" "unprognostic (1.92e-1)" "unprognostic (7.94e-3)" 3.2 8.7 30.5 1.9 37.9 0.0 2.0 35.9 51.2 4.0 46.0 16.6 0.3 16.6 3.1 9.3 8.7 2.5 43.5 55.0 3.2 5.7 0.4 9.3 0.0 2.1 3.8 31.6 10.1 1.2 13.3 0.2 3.0 14.7 1.0 3.3 3.3 8.2 4.7 2.2 3.9 8.3 0.0 3.4 2.4 5.0 11.2 2.6 10.1 2.9 1.5 21.2 3.3 24.8 0.0 0.0 14.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 10.8 0.0 0.0 0.0 0.0 12.6 0.0 0.0 0.7 0.0 0.0 45.7 0.0 14.1 0.0 0.0 0.0 0.0 3.8 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 30.5 37.9 35.9 51.2 55.0 3.2 2.1 3.8 3.0 0.0 11.2 24.8 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 7.4 0.0 0.0 0.0 0.0 0.7 0.0 1.5 0.0 0.1 0.0 1.7 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 2.3 0.0 0.0 GALNT18 "GalNAc-T18, GALNT15, GALNTL4, MGC71806" ENSG00000110328 "Polypeptide N-acetylgalactosaminyltransferase 18" Q6P9A2 11 11270877-11622005 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 149.5;Excitatory neurons: 104.4;Inhibitory neurons: 156.3;Microglial cells: 79.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A-431: 42.1;HaCaT: 52.4;HBEC3-KT: 36.5;PC-3: 36.4;RPMI-8226: 39.3;SK-BR-3: 47.2;U-87 MG: 33.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA012955, HPA070681" Approved Approved "Golgi apparatus,Vesicles,Cytosol" NA NA 300000 "Cluster 82: Adipose tissue - ECM organization" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Golgi apparatus" "Vesicles, Cytosol" "HPA012955: AB_1849460, HPA070681: " "unprognostic (1.26e-1)" "unprognostic (2.80e-1)" "unprognostic (3.69e-2)" "prognostic unfavorable (1.29e-4)" "unprognostic (7.37e-2)" "unprognostic (1.22e-1)" "unprognostic (6.42e-3)" "unprognostic (6.68e-2)" "unprognostic (6.04e-2)" "unprognostic (2.05e-1)" "unprognostic (5.24e-2)" "unprognostic (1.70e-1)" "unprognostic (2.66e-3)" "unprognostic (3.54e-2)" "unprognostic (1.63e-1)" "unprognostic (2.10e-1)" "unprognostic (1.81e-2)" 18.0 4.7 19.1 4.1 17.7 0.0 15.6 17.1 20.8 13.0 10.7 24.8 3.0 24.0 2.4 7.7 12.0 11.2 26.9 29.5 12.9 26.5 10.5 51.2 5.4 12.2 17.2 4.9 8.2 9.8 6.4 24.4 13.9 13.0 3.2 3.6 17.0 9.3 10.7 13.0 8.8 13.3 12.3 3.6 6.8 14.7 19.7 6.3 42.8 6.2 3.3 11.7 11.5 12.9 42.1 15.0 2.0 9.1 0.0 0.0 0.3 4.5 11.2 0.6 0.0 1.7 5.4 0.1 3.1 0.1 5.6 52.4 9.9 36.5 0.1 0.0 14.6 0.0 0.1 0.1 0.5 0.0 0.0 0.2 14.9 0.0 13.5 0.0 0.0 18.5 0.0 0.1 1.9 10.2 0.5 0.1 1.5 0.1 36.4 0.0 0.0 39.3 27.5 5.1 0.6 4.1 7.6 47.2 0.3 1.4 9.9 0.1 0.0 0.7 8.1 0.4 0.2 0.0 0.0 0.0 33.6 0.0 10.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.1 17.7 17.1 20.8 29.5 12.9 12.2 17.2 13.9 12.3 19.7 12.9 40.5 44.8 6.9 149.5 0.1 5.6 6.6 18.3 12.0 1.6 1.6 2.5 8.5 30.0 13.7 20.2 2.1 49.2 0.4 0.8 15.6 19.9 2.2 1.9 0.4 40.6 0.0 0.0 104.4 4.0 3.5 5.4 0.0 1.3 1.3 16.7 18.5 2.6 2.6 0.0 156.3 0.4 8.2 0.8 1.1 1.4 1.5 0.4 1.8 79.6 0.0 43.1 0.0 8.5 10.5 7.3 0.2 3.0 0.2 13.4 0.0 40.8 14.3 2.1 13.1 15.1 7.4 0.6 1.1 1.8 5.4 15.5 0.3 46.7 1.1 1.9 GALNT2 GalNAc-T2 ENSG00000143641 "Polypeptide N-acetylgalactosaminyltransferase 2" Q10471 1 230057990-230282122 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Congenital disorder of glycosylation, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Exocrine glandular cells: 133.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "WM-115: 429.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA011222 Supported Supported "Golgi apparatus" "Intracellular and membrane" NA NA 13000000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 17: WM-115 - Nervous system development" "Cluster 55: Plasma cells - Humoral immune response" "Golgi apparatus" "HPA011222: AB_1849446" "unprognostic (1.26e-1)" "prognostic unfavorable (1.22e-6)" "unprognostic (1.15e-2)" "unprognostic (1.35e-2)" "unprognostic (8.70e-3)" "unprognostic (7.77e-3)" "unprognostic (1.25e-1)" "prognostic unfavorable (8.48e-8)" "unprognostic (2.93e-1)" "unprognostic (1.93e-1)" "unprognostic (1.70e-2)" "unprognostic (9.65e-2)" "prognostic unfavorable (2.79e-13)" "unprognostic (3.79e-3)" "unprognostic (1.49e-1)" "unprognostic (3.64e-2)" "unprognostic (1.89e-1)" 32.9 49.6 17.0 34.8 19.9 13.9 21.9 15.2 16.7 24.7 22.0 28.9 19.5 27.1 6.9 21.0 22.4 21.2 27.4 15.8 18.6 18.5 100.1 27.1 14.0 23.0 19.5 39.2 68.1 9.9 13.6 27.6 18.3 21.4 12.4 19.8 22.1 14.3 67.4 14.7 23.6 25.0 15.3 17.4 33.1 19.7 25.1 42.8 19.0 27.4 11.2 33.4 19.5 15.5 79.5 103.7 59.9 71.4 112.4 95.3 122.8 146.3 90.0 58.4 55.6 45.2 146.5 20.0 106.2 77.7 135.9 150.7 39.9 123.0 48.6 200.1 52.0 60.7 217.2 50.9 60.9 23.4 114.8 136.9 59.8 78.0 30.9 127.3 69.2 110.1 77.0 29.6 65.6 21.8 122.3 23.9 82.1 52.8 97.7 134.3 85.5 61.7 57.4 92.9 18.9 70.1 148.4 7.9 91.0 31.7 46.5 43.5 165.3 56.7 107.9 129.5 118.0 97.9 60.3 44.4 146.1 46.3 429.7 1.5 10.7 3.6 4.4 9.3 3.2 3.4 2.6 4.5 7.8 5.8 2.5 5.0 3.2 2.8 10.2 13.2 3.3 7.7 17.0 19.9 15.2 16.7 15.8 18.6 23.0 19.5 18.3 15.3 25.1 15.5 18.6 16.0 21.3 71.5 32.1 15.3 20.0 52.8 20.5 30.8 13.8 10.7 13.6 18.6 30.1 23.9 33.3 7.3 21.7 24.1 5.9 49.7 47.2 18.7 15.4 17.9 16.8 27.6 67.3 133.0 123.4 36.1 21.4 24.5 13.3 20.5 19.6 98.8 24.9 28.6 82.0 18.9 4.1 42.4 9.7 24.6 35.8 28.9 24.9 106.8 44.0 10.9 18.6 72.9 44.6 88.5 21.6 29.3 109.0 23.5 17.9 19.2 23.5 73.5 13.1 33.1 25.4 3.4 14.0 16.6 8.0 16.6 21.2 32.8 17.6 29.9 GALNT3 "GalNAc-T3, HFTC, HHS" ENSG00000115339 "Polypeptide N-acetylgalactosaminyltransferase 3" Q14435 2 165747588-165794659 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "stomach 1: 77.3" "Cell type enhanced" "Detected in many" "Intestinal goblet cells: 152.8;Pancreatic endocrine cells: 188.1;Prostatic glandular cells: 155.7;Urothelial cells: 274.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 50.5" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "CAPAN-2: 85.4;HaCaT: 108.3;HBEC3-KT: 69.2;hTCEpi: 88.2;OE19: 201.1" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA007613 Enhanced Supported "Golgi apparatus" NA NA 440000 "Cluster 46: Basophils - DNA binding" "Cluster 37: Intestine - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 22: Epithelial cell types - Mixed function" "Golgi apparatus" "HPA007613: AB_1078941" "unprognostic (1.95e-1)" "prognostic unfavorable (2.08e-4)" "unprognostic (1.16e-3)" "unprognostic (2.78e-1)" "unprognostic (3.22e-2)" "prognostic unfavorable (4.10e-4)" "unprognostic (4.13e-2)" "unprognostic (4.47e-2)" "unprognostic (2.74e-1)" "unprognostic (6.44e-2)" "unprognostic (3.62e-3)" "unprognostic (1.33e-1)" "unprognostic (1.14e-2)" "unprognostic (1.79e-2)" "unprognostic (3.54e-1)" "unprognostic (1.28e-1)" "unprognostic (1.57e-1)" 1.5 1.7 1.7 8.4 2.1 54.0 26.0 2.7 1.8 29.3 4.3 48.9 43.5 5.2 9.3 27.4 38.8 32.2 0.6 1.8 3.4 10.9 2.4 14.0 3.7 4.5 5.2 6.8 26.2 6.9 9.8 6.4 3.3 25.2 53.2 3.7 55.3 8.2 0.3 15.3 39.5 2.5 7.0 20.1 77.3 25.8 1.9 3.3 25.4 0.4 12.3 17.3 12.6 5.4 61.5 0.0 0.6 0.2 0.1 2.6 43.0 18.3 7.7 6.6 16.0 32.0 85.4 0.4 0.1 0.0 0.1 108.3 0.0 69.2 13.5 1.3 13.0 0.0 14.9 0.3 0.3 14.5 0.4 0.5 88.2 0.0 30.3 2.1 0.1 2.9 0.0 55.0 5.0 42.7 0.5 5.6 0.1 201.1 7.8 0.2 0.0 1.7 17.8 42.0 6.5 0.1 0.3 49.6 16.8 1.9 21.7 0.9 0.5 0.1 1.0 0.1 0.3 34.4 16.3 1.3 0.2 14.0 0.6 50.5 6.8 32.2 10.2 9.0 7.5 6.6 3.1 5.8 11.4 6.0 1.0 3.4 25.2 10.6 13.8 17.3 5.6 6.2 1.7 2.1 2.7 1.8 1.8 3.4 4.5 5.2 3.3 7.0 1.9 5.4 1.0 12.8 34.4 7.8 13.6 38.0 107.9 36.5 29.6 0.6 45.0 26.8 0.4 35.8 45.9 66.2 0.0 8.5 37.7 68.6 3.9 70.2 127.5 91.8 5.2 2.9 23.4 1.3 10.5 113.2 22.5 2.3 102.4 70.5 45.7 0.7 1.1 0.6 8.2 0.0 5.1 152.8 28.5 1.9 12.4 14.1 2.5 8.3 16.0 1.0 7.5 16.1 15.5 27.6 1.4 188.1 46.5 0.4 29.7 155.7 32.6 3.1 89.3 1.0 6.6 0.6 4.3 71.5 1.1 42.4 41.3 11.2 14.4 1.2 61.8 274.4 GALNT4 GalNAc-T4 ENSG00000257594 "Polypeptide N-acetylgalactosaminyltransferase 4" Q8N4A0 12 89519412-89524796 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "stomach 1: 31.6" "Cell type enhanced" "Detected in some" "Gastric mucus-secreting cells: 11.2;Glandular and luminal cells: 3.4;Paneth cells: 3.4;Respiratory ciliated cells: 2.9" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "PC-3: 22.2" HPA076116 Approved "Golgi apparatus" NA NA 520000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 37: Intestine - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 16: Pancreatic endocrine cells - Mixed function" "Golgi apparatus" "HPA076116: AB_2686778" "unprognostic (2.96e-2)" "unprognostic (7.65e-3)" "unprognostic (8.76e-2)" "unprognostic (3.94e-5)" "unprognostic (3.50e-1)" "unprognostic (4.87e-2)" "unprognostic (2.02e-1)" "unprognostic (2.92e-2)" "unprognostic (2.78e-1)" "unprognostic (4.07e-2)" "unprognostic (1.28e-2)" "unprognostic (2.24e-1)" "unprognostic (5.81e-6)" "unprognostic (2.34e-1)" "unprognostic (1.91e-1)" "unprognostic (9.65e-2)" "unprognostic (2.52e-1)" 3.1 2.2 1.2 6.1 1.7 7.7 4.0 1.3 1.7 16.1 1.1 18.6 17.3 13.5 2.6 3.3 11.9 11.8 1.9 1.3 1.7 5.6 4.8 3.7 3.4 1.9 1.4 2.8 5.0 1.9 1.2 3.0 1.8 3.8 17.3 3.9 16.1 2.2 0.3 1.9 18.4 3.1 1.7 5.9 31.6 0.8 1.5 1.2 3.2 1.7 3.5 4.9 1.5 1.7 3.2 9.4 3.3 18.2 6.3 9.1 2.3 7.6 3.6 3.1 3.3 3.5 5.8 0.0 1.9 5.7 1.3 4.8 0.9 4.9 5.2 8.4 2.1 3.9 1.6 3.2 3.3 3.8 8.3 4.1 2.2 6.3 2.7 7.1 9.9 0.7 2.5 1.7 4.8 2.6 0.3 7.2 2.2 7.1 22.2 1.0 0.6 1.6 9.2 9.6 0.2 1.7 1.0 5.0 7.0 3.1 10.0 3.7 9.1 6.2 2.2 3.9 2.7 1.7 2.9 1.6 3.2 2.0 3.8 3.9 3.3 1.6 2.0 4.9 3.5 1.3 1.1 1.5 2.2 1.9 1.5 1.3 3.2 4.9 5.3 0.8 1.3 2.0 1.2 1.7 1.3 1.7 1.3 1.7 1.9 1.4 1.8 1.7 1.5 1.7 0.1 0.0 0.6 0.0 0.6 0.0 0.0 0.0 1.2 0.3 0.0 0.1 0.0 0.0 1.8 0.0 0.0 0.0 0.1 1.0 0.0 0.0 0.0 1.0 0.6 0.1 0.0 1.3 0.0 0.2 0.0 0.7 11.2 3.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 3.4 0.0 0.1 0.0 0.4 0.0 2.9 0.9 0.0 0.1 0.5 0.0 0.0 0.9 0.0 0.0 0.3 0.1 0.1 0.1 GALNT5 GalNAc-T5 ENSG00000136542 "Polypeptide N-acetylgalactosaminyltransferase 5" Q7Z7M9 2 157257705-157318491 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 13.5;lung: 10.2;stomach 1: 12.8" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 157.0;Distal enterocytes: 48.3;Intestinal goblet cells: 75.5;Pancreatic endocrine cells: 53.5;Prostatic glandular cells: 40.1;Urothelial cells: 115.1" "Low cancer specificity" "Detected in many" "Region enriched" "Detected in single" 9 "cerebellum: 4.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A-431: 45.3;BJ: 29.8;BJ hTERT+: 53.5;fHDF/TERT166: 64.5;HaCaT: 51.8;K-562: 30.7;LHCN-M2: 52.0" "Not detected" "Not detected" "Low region specificity" "Detected in single" "HPA008963, HPA009035" Approved Approved "Nucleoli,Golgi apparatus,Vesicles,Cytosol" NA NA 1300000 "Cluster 37: Intestine - Unknown function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 27: Mucus-secreting cells - Mucin production" "Golgi apparatus, Cytosol" "Nucleoli, Vesicles" "HPA008963: AB_1078942, HPA009035: AB_1078943" "unprognostic (6.34e-3)" "unprognostic (9.31e-2)" "unprognostic (2.11e-2)" "unprognostic (9.89e-2)" "unprognostic (3.19e-2)" "unprognostic (2.46e-2)" "unprognostic (4.63e-3)" "unprognostic (1.88e-1)" "unprognostic (1.09e-1)" "unprognostic (6.93e-2)" "unprognostic (4.01e-3)" "unprognostic (1.78e-1)" "unprognostic (1.15e-2)" "unprognostic (6.27e-2)" "unprognostic (1.29e-1)" "unprognostic (1.88e-1)" "unprognostic (9.48e-3)" 0.1 0.0 0.0 0.7 0.0 0.6 1.1 4.0 0.3 1.1 5.2 10.6 2.2 0.1 0.1 4.5 0.0 2.7 0.4 0.4 0.0 0.0 0.0 10.2 0.0 0.1 0.1 0.1 0.0 0.1 0.6 0.0 0.2 0.7 13.5 0.1 8.2 0.1 0.0 0.3 4.1 0.4 0.0 0.1 12.8 0.1 0.1 0.1 0.1 0.1 1.7 4.5 4.6 0.2 45.3 4.8 0.0 0.0 2.0 17.0 0.0 29.8 53.5 0.5 1.1 1.9 24.4 0.0 0.1 64.5 0.0 51.8 0.9 10.0 3.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 10.0 0.2 0.0 0.9 0.0 0.0 0.0 30.7 0.0 52.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.9 0.1 0.7 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 25.4 0.3 0.6 0.1 0.0 0.1 0.0 4.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.0 0.3 0.4 0.0 0.1 0.1 0.2 0.0 0.1 0.2 0.1 157.0 36.1 0.0 0.1 0.8 13.3 20.2 6.2 0.0 0.5 2.8 0.5 2.8 32.9 0.0 0.0 0.0 0.2 48.3 0.0 1.2 6.9 1.2 0.0 0.6 2.4 5.2 0.8 3.2 0.0 2.1 35.7 2.8 0.0 0.0 0.0 0.3 0.0 0.0 0.1 75.5 6.1 0.0 0.7 0.5 0.0 0.3 3.6 0.0 1.6 0.0 0.0 0.0 0.1 53.5 26.4 0.0 1.4 40.1 3.1 0.2 10.0 0.0 0.0 0.5 1.2 2.6 0.5 4.5 0.1 0.0 0.3 0.0 22.7 115.1 GALNT6 GalNAc-T6 ENSG00000139629 "Polypeptide N-acetylgalactosaminyltransferase 6" Q8NCL4 12 51351247-51392867 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "stomach 1: 62.6" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 49.2;Gastric mucus-secreting cells: 130.5;granulocytes: 164.5;Oligodendrocytes: 57.6" "Cancer enhanced" "Detected in many" "breast cancer: 31.4" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "eosinophil: 29.1" "Group enriched" "Detected in all" 4 "granulocytes: 29.1;monocytes: 9.7;NK-cells: 15.5" "Cell line enhanced" "Detected in many" "BJ hTERT+: 107.0;CACO-2: 104.1;OE19: 97.6;SK-BR-3: 110.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA011762, HPA017086" Enhanced Approved "Nucleoplasm,Golgi apparatus" "Intracellular and membrane" NA NA 4800000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 4: Stomach - Digestion" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 60: Granulocytes - Receptor signaling" "Nucleoplasm, Golgi apparatus" "HPA011762: AB_1849450, HPA017086: AB_1849452" "unprognostic (2.03e-1)" "unprognostic (6.65e-2)" "unprognostic (2.26e-2)" "prognostic favorable (9.85e-4)" "unprognostic (1.35e-2)" "unprognostic (1.18e-1)" "unprognostic (7.15e-3)" "unprognostic (2.05e-1)" "unprognostic (2.27e-2)" "prognostic favorable (5.40e-4)" "unprognostic (1.88e-2)" "unprognostic (5.25e-2)" "unprognostic (7.13e-4)" "unprognostic (5.65e-3)" "unprognostic (3.18e-1)" "unprognostic (2.16e-2)" "unprognostic (1.18e-2)" 1.7 3.1 3.3 8.0 11.8 9.6 18.1 7.2 9.1 32.2 0.2 6.7 21.2 1.3 24.7 2.4 6.5 2.4 0.4 4.2 7.3 2.9 1.2 5.7 7.2 8.8 11.1 0.9 8.3 1.4 1.1 9.6 10.8 0.9 6.9 0.1 31.0 3.2 0.4 5.6 21.6 1.6 5.2 8.2 62.6 0.6 9.7 6.8 2.5 0.1 5.9 3.7 1.8 18.1 39.0 4.1 0.7 0.1 0.0 0.6 59.8 63.0 107.0 25.4 17.0 104.1 19.0 0.5 5.8 34.4 0.0 35.9 1.5 27.3 17.1 8.3 4.1 24.6 0.7 0.8 1.0 13.6 82.2 2.3 25.2 23.1 23.0 0.2 65.7 14.2 5.4 1.0 0.1 73.7 43.2 10.1 5.3 97.6 66.6 0.2 0.1 10.3 21.3 2.2 0.5 23.5 0.4 110.5 0.1 12.2 59.3 5.9 75.7 0.2 12.9 0.2 0.3 2.1 0.5 3.6 7.2 29.5 0.2 7.1 5.8 29.1 3.8 5.2 1.6 1.2 2.2 3.1 4.5 3.3 3.4 2.9 1.1 15.5 9.7 4.1 1.7 3.2 3.3 11.8 7.2 9.1 4.2 7.3 8.8 11.1 10.8 5.2 9.7 18.1 0.8 3.2 2.4 0.3 11.8 2.9 3.8 5.8 5.7 0.4 38.9 18.4 1.3 1.5 15.6 1.8 0.0 14.1 11.3 12.4 3.9 2.6 2.0 3.5 0.3 4.1 0.0 15.3 1.0 10.9 49.2 1.6 130.5 5.8 164.5 3.8 1.4 0.3 14.4 0.0 0.5 17.4 2.0 16.3 10.3 1.5 0.0 15.1 1.8 1.0 7.2 0.2 9.2 0.0 57.6 24.3 33.9 0.4 5.5 7.6 39.6 2.0 12.4 0.0 0.0 1.5 1.5 0.4 1.6 2.6 9.2 4.8 14.9 1.8 11.8 5.8 GALNT7 GALNAC-T7 ENSG00000109586 "Polypeptide N-acetylgalactosaminyltransferase 7" Q86SF2 4 173168811-173323967 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 143.4;Inhibitory neurons: 172.0;Intestinal goblet cells: 126.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA064243, HPA065317" Enhanced Approved "Nucleoplasm,Golgi apparatus" NA NA 6200000 "Cluster 5: Granulocytes - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 27: Mucus-secreting cells - Mucin production" "Golgi apparatus" Nucleoplasm "HPA064243: AB_2685223, HPA065317: AB_2685465" "unprognostic (1.81e-1)" "unprognostic (2.11e-1)" "prognostic favorable (4.53e-4)" "unprognostic (1.37e-3)" "unprognostic (1.48e-1)" "unprognostic (6.86e-3)" "unprognostic (2.72e-2)" "unprognostic (1.77e-1)" "unprognostic (2.85e-2)" "unprognostic (2.25e-1)" "prognostic unfavorable (7.65e-4)" "unprognostic (1.33e-1)" "unprognostic (4.66e-3)" "unprognostic (3.05e-1)" "unprognostic (3.19e-1)" "unprognostic (2.34e-3)" "unprognostic (5.97e-2)" 6.4 6.4 6.4 16.3 8.8 11.5 23.3 34.2 8.3 25.1 3.5 47.8 29.1 16.9 7.0 14.9 9.8 15.6 5.9 6.6 7.8 7.8 2.9 9.6 12.2 12.6 8.3 11.2 22.2 8.7 5.2 13.0 11.7 39.7 52.8 22.4 27.4 8.1 1.4 3.9 33.7 16.7 10.1 11.0 65.7 11.9 8.4 60.0 13.5 3.9 9.8 17.0 5.9 16.0 71.1 37.2 35.0 11.2 18.6 27.1 50.3 18.1 20.5 16.7 23.0 11.5 109.9 39.4 13.3 16.6 45.2 59.2 15.0 32.0 22.7 154.3 29.1 47.8 72.2 0.4 12.2 71.6 32.8 17.5 28.3 37.6 18.9 63.4 112.3 28.2 32.6 59.3 86.0 23.5 52.7 39.4 34.8 70.2 24.0 52.1 32.4 10.2 123.2 32.8 28.2 21.5 8.5 50.4 25.4 45.3 20.2 21.0 135.6 11.9 52.3 0.6 40.0 17.2 0.2 20.8 48.6 42.3 43.6 13.2 14.3 18.9 5.1 7.5 7.2 6.2 5.7 5.3 12.4 3.3 4.4 3.3 21.3 7.5 8.0 5.0 9.2 6.4 6.4 8.8 34.2 8.3 6.6 7.8 12.6 8.3 11.7 10.1 8.4 16.0 10.0 6.4 38.0 72.8 12.1 1.8 9.0 12.3 4.0 47.9 41.1 19.8 9.6 8.6 36.0 20.2 2.1 1.4 16.4 143.4 0.0 14.4 2.5 28.3 13.3 11.3 22.8 12.0 74.4 48.9 3.7 12.1 102.4 52.9 24.1 14.8 12.1 0.2 10.3 10.1 172.0 126.8 24.4 17.9 6.2 4.2 9.3 17.2 8.8 62.8 16.3 8.1 5.2 71.4 54.1 39.9 50.0 5.3 6.6 52.8 63.7 10.0 17.4 25.5 13.1 16.1 11.7 3.8 5.5 14.9 1.1 0.8 9.9 13.1 48.6 19.4 GALNT8 GALNAC-T8 ENSG00000130035 "Polypeptide N-acetylgalactosaminyltransferase 8" Q9NY28 12 4720400-4851927 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "intestine: 31.3;testis: 13.5" "Group enriched" "Detected in some" 6 "Early spermatids: 95.2;Intestinal goblet cells: 47.0;Late spermatids: 150.2" "Group enriched" "Detected in some" 4 "colorectal cancer: 1.2;glioma: 1.8;pancreatic cancer: 0.8;testis cancer: 2.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "Karpas-707: 23.4;U-266/84: 7.6" "Not detected" "Not detected" "HPA012638, HPA073461" Supported Approved "Golgi apparatus,Vesicles" "Intracellular and membrane" NA No "Cluster 22: NK-cells - Unknown function" "Cluster 45: Intestine - Brush border" "Cluster 2: Karpas-707 - Immune response" "Cluster 31: Spermatids - Spermatogenesis" "Golgi apparatus, Vesicles" "HPA012638: AB_2294503, HPA073461: AB_2686604" "unprognostic (2.36e-2)" "unprognostic (1.95e-1)" "unprognostic (1.13e-2)" "unprognostic (1.75e-2)" "unprognostic (6.24e-2)" "unprognostic (2.87e-1)" "unprognostic (2.59e-2)" "unprognostic (3.79e-1)" "unprognostic (2.72e-1)" "unprognostic (5.76e-2)" "unprognostic (8.06e-5)" "unprognostic (1.16e-2)" "unprognostic (6.67e-5)" "unprognostic (5.18e-2)" "unprognostic (2.59e-2)" "unprognostic (2.53e-1)" "unprognostic (1.33e-2)" 0.4 0.6 3.2 1.8 3.3 0.0 0.6 2.7 5.1 0.5 2.0 14.0 5.7 0.3 0.1 0.1 0.6 0.0 2.5 3.2 2.8 0.4 0.2 0.3 0.2 3.4 3.2 0.7 0.2 0.0 2.8 0.1 3.3 0.4 31.3 0.2 0.4 0.3 0.1 0.2 12.6 0.8 2.9 0.5 0.5 13.5 3.3 0.0 0.2 0.0 0.0 0.4 0.3 4.1 0.0 0.0 0.5 0.1 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 23.4 0.0 0.0 0.0 0.1 3.1 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 7.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.1 0.1 0.0 3.2 3.3 2.7 5.1 3.2 2.8 3.4 3.2 3.3 2.9 3.3 4.1 0.1 6.4 0.5 1.3 0.5 0.0 0.0 0.1 0.6 2.1 0.1 2.3 4.5 0.0 0.0 0.0 0.0 0.0 1.5 1.8 0.0 0.0 95.2 0.5 0.1 0.5 6.6 0.0 1.1 0.4 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 4.7 47.0 0.0 0.0 0.0 150.2 1.5 0.1 0.0 3.7 0.2 0.5 0.0 15.1 7.4 0.2 0.6 2.6 0.0 0.1 1.0 1.0 0.0 0.6 6.6 0.7 0.1 12.3 8.3 0.0 0.0 0.0 0.8 0.3 2.2 0.0 GALNT9 GALNAC-T9 ENSG00000182870 "Polypeptide N-acetylgalactosaminyltransferase 9" Q9HCQ5 12 132196372-132329589 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 22.5;kidney: 9.4;thyroid gland: 13.0" "Cell type enhanced" "Detected in some" "Bipolar cells: 7.7;Collecting duct cells: 27.6;Excitatory neurons: 37.1;Inhibitory neurons: 13.1;Proximal tubular cells: 8.2" "Group enriched" "Detected in some" 5 "glioma: 0.9;ovarian cancer: 0.5;renal cancer: 1.6;thyroid cancer: 1.0" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 4 "U-87 MG: 13.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA075016 Approved Vesicles NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 7: Kidney - Transmembrane transport" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Vesicles "HPA075016: AB_2686729" "unprognostic (1.13e-1)" "unprognostic (3.47e-2)" "unprognostic (1.47e-1)" "unprognostic (6.44e-2)" "unprognostic (1.03e-1)" "unprognostic (6.53e-2)" "unprognostic (2.65e-1)" "unprognostic (1.32e-2)" "unprognostic (2.03e-1)" "unprognostic (1.64e-3)" "unprognostic (2.85e-1)" "unprognostic (6.62e-2)" "unprognostic (5.17e-2)" "unprognostic (1.89e-1)" "unprognostic (1.71e-1)" "unprognostic (3.89e-2)" "unprognostic (5.69e-2)" 9.3 1.2 8.3 0.1 11.9 0.0 0.1 19.9 22.5 3.9 0.0 1.5 0.2 0.8 2.3 0.1 1.9 0.0 0.8 11.2 2.9 9.4 0.2 0.5 0.3 6.1 4.4 1.3 0.1 0.2 8.4 0.0 5.9 1.0 0.0 0.6 0.2 0.3 0.1 0.1 0.5 0.0 1.0 0.9 0.6 0.7 9.6 0.1 13.0 0.0 0.0 0.5 0.8 11.0 0.0 0.9 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.3 0.0 3.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 13.5 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.3 11.9 19.9 22.5 11.2 2.9 6.1 4.4 5.9 1.0 9.6 11.0 0.0 0.0 0.6 2.6 0.0 0.0 0.5 0.0 0.0 7.7 0.1 0.0 1.6 0.0 0.0 27.6 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.6 0.4 1.3 0.0 0.0 37.1 0.0 0.0 2.7 0.0 0.8 1.3 0.0 0.0 0.0 0.2 3.3 13.1 0.0 0.0 0.0 0.0 0.3 0.6 0.1 0.0 5.6 0.0 1.7 0.0 2.0 2.9 0.1 0.0 1.9 0.0 0.6 0.0 8.2 0.0 3.3 0.0 0.9 0.6 0.0 0.1 0.0 0.1 0.1 0.0 2.0 0.1 0.8 GALNTL6 "GalNAc-T6L, GALNT17" ENSG00000174473 "Polypeptide N-acetylgalactosaminyltransferase like 6" Q49A17 4 171812254-173041559 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enhanced" "Detected in some" "brain: 7.8;lymphoid tissue: 2.5" "Group enriched" "Detected in some" 17 "Excitatory neurons: 424.4;Inhibitory neurons: 1567.9" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in single" "memory B-cell: 1.6" "Lineage enriched" "Detected in single" 8 "B-cells: 1.6" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031019 Uncertain "Intracellular and membrane" NA NA "Cluster 37: B-cells - Transcription" "Cluster 65: Brain - Ion transport" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA031019: AB_10601653" "unprognostic (6.84e-2)" "unprognostic (1.28e-1)" "unprognostic (2.01e-2)" "unprognostic (5.73e-2)" "unprognostic (7.50e-2)" "unprognostic (8.32e-2)" "unprognostic (3.25e-1)" "unprognostic (9.55e-2)" "unprognostic (1.06e-1)" "unprognostic (1.83e-1)" "unprognostic (2.06e-1)" "unprognostic (2.80e-1)" "unprognostic (1.79e-2)" "unprognostic (1.90e-1)" "unprognostic (1.11e-2)" "unprognostic (4.84e-3)" "unprognostic (1.73e-2)" 0.0 0.2 3.6 0.4 2.8 0.4 0.2 0.5 4.0 1.0 0.0 0.3 0.2 0.0 0.0 0.0 0.2 0.1 0.1 6.0 7.8 0.0 0.1 0.1 0.3 0.2 5.3 0.0 0.1 0.0 0.0 0.0 2.3 0.7 0.2 1.3 0.3 0.0 0.3 0.1 0.5 0.0 1.1 2.5 1.0 2.4 4.0 0.0 0.1 1.4 0.1 0.1 0.4 0.6 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.8 0.0 0.0 0.1 0.5 0.0 0.2 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.2 0.0 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.1 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 2.8 0.5 4.0 6.0 7.8 0.2 5.3 2.3 1.1 4.0 0.6 0.0 0.0 1.5 10.4 2.4 0.3 0.1 0.0 0.0 1.6 0.3 0.0 1.2 0.0 1.8 0.0 0.0 0.0 0.0 0.2 0.0 0.0 13.5 0.0 0.0 0.1 0.0 0.0 424.4 4.1 0.0 0.3 2.0 0.0 0.0 2.4 0.0 0.0 0.1 0.0 1567.9 2.6 0.0 1.6 0.0 21.1 0.3 0.9 5.4 13.1 0.0 0.1 0.0 57.3 9.1 0.0 0.0 0.0 0.0 0.5 0.1 0.0 0.0 0.1 0.0 1.2 0.2 1.6 1.6 0.0 0.3 0.0 0.0 0.1 0.4 0.1 GALT ENSG00000213930 "Galactose-1-phosphate uridylyltransferase" P07902 9 34638133-34651035 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Carbohydrate metabolism, Galactose metabolism" "Nucleotidyltransferase, Transferase" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 50.0" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004868, HPA005729" Enhanced Approved Cytosol NA NA 260000 "Cluster 37: B-cells - Transcription" "Cluster 85: Liver - Metabolism" "Cluster 20: HeLa - Mitochondria" "Cluster 47: Cytotrophoblasts - Unknown function" Cytosol "HPA004868: AB_1079130, HPA005729: AB_1079131" "unprognostic (2.38e-1)" "unprognostic (8.92e-2)" "unprognostic (1.45e-3)" "unprognostic (1.54e-1)" "unprognostic (5.46e-2)" "unprognostic (1.22e-1)" "unprognostic (2.94e-1)" "unprognostic (2.13e-1)" "unprognostic (3.97e-2)" "unprognostic (1.13e-2)" "prognostic favorable (3.11e-5)" "unprognostic (9.68e-2)" "prognostic favorable (6.25e-6)" "unprognostic (7.90e-2)" "unprognostic (2.74e-1)" "unprognostic (3.56e-1)" "unprognostic (7.75e-2)" 6.7 14.0 5.3 6.7 5.9 8.1 6.3 5.5 6.5 6.9 4.6 8.5 18.3 6.9 5.3 5.3 7.8 6.8 10.4 5.2 6.3 10.0 50.0 6.6 12.0 5.5 5.7 8.2 7.5 13.0 6.1 9.2 5.3 6.4 6.7 6.3 12.3 7.5 10.2 15.2 16.5 4.0 4.5 9.7 8.1 2.4 6.1 7.8 8.2 7.6 7.7 5.3 6.1 4.7 5.5 7.5 6.8 2.4 9.0 9.2 7.8 4.2 12.1 4.3 5.1 9.5 4.8 6.1 4.2 5.2 1.6 2.9 1.3 11.8 0.8 9.7 4.8 2.5 14.7 9.8 8.7 1.4 2.9 12.6 7.4 2.7 3.6 9.3 10.6 8.3 2.3 6.4 7.3 5.1 5.4 10.3 2.3 6.7 1.3 8.4 5.9 3.3 12.5 7.8 1.6 5.7 5.0 9.8 5.4 5.0 9.2 8.2 1.6 1.7 3.4 3.4 0.0 3.9 2.4 1.3 4.1 4.4 10.8 16.5 23.7 11.7 15.4 21.5 21.3 24.8 25.2 21.1 21.5 13.2 15.3 14.8 4.6 29.0 20.4 18.2 30.0 17.6 5.3 5.9 5.5 6.5 5.2 6.3 5.5 5.7 5.3 4.5 6.1 4.7 12.6 6.4 21.2 10.7 19.0 21.7 13.4 19.3 19.4 44.0 10.5 12.1 25.7 14.3 15.4 16.5 47.9 72.5 13.9 17.3 29.4 18.3 7.6 7.8 11.8 14.6 16.3 13.7 9.1 7.3 36.3 18.3 9.2 8.0 20.3 24.7 23.6 69.9 24.1 47.1 12.5 17.0 26.4 15.5 8.7 36.8 18.3 12.4 21.4 5.6 15.9 18.7 34.0 6.0 3.7 6.9 37.5 13.9 10.7 4.7 67.1 46.3 11.1 38.5 6.6 11.2 12.2 4.8 6.6 8.6 20.2 59.1 25.5 27.4 20.4 9.2 GAMT "PIG2, TP53I2" ENSG00000130005 "Guanidinoacetate N-methyltransferase" Q14353 19 1397026-1401570 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Methyltransferase, Transferase" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 615.1;skeletal muscle: 1234.9;tongue: 466.4" "Group enriched" "Detected in many" 4 "Hepatocytes: 718.3;Proximal tubular cells: 417.4" "Cancer enriched" "Detected in all" 5 "liver cancer: 173.2" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "Hep G2: 176.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA051806 Approved NA NA 420000 "Cluster 29: Plasmacytoid DCs - Unknown function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA051806: AB_2681619" "unprognostic (3.25e-1)" "unprognostic (7.74e-3)" "unprognostic (3.22e-2)" "unprognostic (6.32e-2)" "unprognostic (4.35e-2)" "unprognostic (1.86e-1)" "unprognostic (2.92e-2)" "unprognostic (2.80e-2)" "unprognostic (1.14e-1)" "unprognostic (2.27e-1)" "unprognostic (3.41e-2)" "unprognostic (7.10e-2)" "unprognostic (6.36e-2)" "prognostic unfavorable (6.57e-4)" "unprognostic (1.78e-1)" "unprognostic (1.82e-1)" "unprognostic (1.54e-2)" 14.0 26.6 69.4 4.5 74.5 8.8 15.6 68.6 79.1 16.5 53.4 10.9 3.2 10.0 141.9 23.0 14.7 9.9 98.1 67.3 67.1 72.0 615.1 8.1 7.7 71.8 68.3 22.8 229.8 37.8 37.4 4.9 70.4 36.5 2.2 15.0 42.6 17.5 1234.9 32.8 6.4 4.6 68.8 10.7 31.8 55.0 76.1 24.8 22.2 466.4 4.3 12.9 15.3 94.5 21.6 24.1 25.2 56.9 30.9 37.3 34.3 25.2 41.2 31.8 28.7 54.8 15.1 11.3 17.2 30.0 3.8 9.1 39.8 15.5 8.5 81.5 46.2 34.9 20.3 176.7 18.2 0.7 11.5 41.8 5.5 33.8 0.1 44.0 6.9 43.0 50.6 26.6 52.6 22.1 103.9 12.0 28.6 10.7 75.4 103.1 22.3 81.4 38.1 19.5 8.4 58.5 1.9 14.3 32.0 16.1 65.3 48.1 12.2 34.6 35.6 1.9 11.6 119.0 24.8 19.5 32.2 46.1 40.7 3.7 2.5 15.3 18.8 3.4 27.3 22.0 26.3 23.8 11.2 32.3 40.6 30.8 1.5 18.2 6.1 47.3 15.8 14.9 69.4 74.5 68.6 79.1 67.3 67.1 71.8 68.3 70.4 68.8 76.1 94.5 9.2 0.0 7.2 5.5 18.0 58.9 42.1 57.8 116.7 41.0 60.3 99.9 99.3 127.2 12.9 16.5 56.3 35.7 15.4 0.8 92.0 39.9 5.2 6.5 7.4 9.2 7.2 35.8 7.4 33.6 41.2 30.9 10.2 4.0 4.5 43.3 18.9 718.3 81.7 18.5 10.1 1.5 6.1 29.5 13.3 16.0 83.9 13.9 32.0 3.7 4.7 57.3 10.3 4.0 36.7 13.5 0.1 139.5 12.5 24.1 0.1 417.4 6.1 61.7 32.9 77.8 47.1 4.3 22.6 42.1 42.9 12.0 19.7 31.1 3.3 23.2 GART "GARS-AIRS-GART, PGFT, PRGS" ENSG00000159131 "Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase" P22102 21 33503931-33543491 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Purine biosynthesis" "Ligase, Multifunctional enzyme, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002119, HPA005779" Approved Approved Mitochondria,Cytosol NA NA 300000 "Cluster 27: Non-specific - Gene expression" "Cluster 3: T-cells - Adaptive immune response" "Cluster 1: K-562 - Erythropoiesis" "Cluster 39: Non-specific - Basic cellular processes" Cytosol Mitochondria "HPA002119: AB_1849482, HPA005779: AB_1849484" "unprognostic (3.77e-2)" "unprognostic (2.25e-2)" "unprognostic (4.51e-3)" "unprognostic (1.72e-2)" "unprognostic (2.30e-2)" "prognostic unfavorable (5.05e-5)" "prognostic unfavorable (9.82e-5)" "unprognostic (2.50e-2)" "unprognostic (2.76e-3)" "unprognostic (2.92e-1)" "prognostic unfavorable (2.19e-4)" "unprognostic (1.98e-3)" "prognostic unfavorable (3.95e-6)" "unprognostic (1.36e-2)" "unprognostic (2.31e-1)" "unprognostic (2.28e-1)" "unprognostic (1.57e-1)" 24.1 20.3 9.2 24.2 12.2 18.8 24.3 11.3 11.9 16.4 10.1 23.2 22.1 18.3 17.1 24.8 21.8 15.9 20.7 8.6 10.5 21.0 29.7 16.0 30.3 11.0 10.3 19.0 22.3 19.9 12.8 26.1 11.7 17.0 29.1 20.9 16.8 16.7 29.1 17.4 19.4 26.3 11.3 20.0 19.7 29.3 10.9 34.4 20.8 21.9 38.6 32.2 16.5 14.0 132.2 61.5 90.3 98.8 61.1 64.2 100.3 82.6 70.8 96.8 101.5 117.7 108.9 174.8 48.5 55.6 124.9 67.9 189.0 130.4 138.3 91.3 111.7 265.2 68.5 78.6 85.2 148.6 66.3 57.3 86.5 113.3 162.5 48.1 91.5 138.4 312.4 108.5 84.9 63.6 158.2 100.0 194.4 186.3 71.8 131.1 166.6 246.7 74.7 69.4 93.1 84.1 116.9 89.1 107.1 81.0 113.0 93.9 68.7 64.9 76.9 56.1 90.9 106.8 159.6 193.0 67.1 171.3 96.2 9.0 24.0 16.3 25.9 33.9 31.4 29.7 25.2 27.1 31.6 24.5 26.4 26.2 10.6 43.9 30.6 23.2 34.1 22.8 9.2 12.2 11.3 11.9 8.6 10.5 11.0 10.3 11.7 11.3 10.9 14.0 21.1 19.2 19.8 17.3 30.1 46.0 50.3 34.1 38.1 18.5 18.6 17.3 19.3 11.5 28.0 14.7 35.5 41.2 21.8 12.4 23.5 28.4 21.7 23.3 36.9 21.9 13.1 40.3 19.1 24.2 37.4 27.2 21.4 23.4 7.6 31.8 16.1 18.0 23.6 5.0 21.1 17.1 22.4 17.0 12.0 6.6 17.4 17.0 12.4 10.3 19.8 13.3 22.6 17.6 19.3 31.5 12.7 18.0 22.7 54.3 16.4 14.3 17.8 28.5 13.1 23.0 23.9 57.2 27.6 34.4 45.9 25.6 21.2 55.0 24.1 46.6 GATM AGAT ENSG00000171766 "Glycine amidinotransferase" P50440 15 45361124-45402327 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 12 "kidney: 2099.3;liver: 2804.2;pancreas: 2935.3" "Group enriched" "Detected in many" 8 "Hepatocytes: 1495.2;Proximal tubular cells: 3703.0" "Cancer enhanced" "Detected in all" "liver cancer: 135.2" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 5 "memory B-cell: 11.0;myeloid DC: 6.6;naive B-cell: 5.4;plasmacytoid DC: 6.8" "Group enriched" "Detected in many" 5 "B-cells: 11.0;dendritic cells: 6.8" "Group enriched" "Detected in many" 4 "RH-30: 210.1;RT4: 55.8;U-266/70: 126.3;U-266/84: 165.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA026077 Enhanced Supported Mitochondria NA NA 600000 "Cluster 43: B-cells - Humoral immune response" "Cluster 29: Non-specific - Vesicular transport" "Cluster 29: U-266 - Adaptive immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Mitochondria "HPA026077: AB_1849528" "unprognostic (1.91e-1)" "unprognostic (1.33e-2)" "unprognostic (2.77e-2)" "unprognostic (6.57e-2)" "unprognostic (9.43e-2)" "unprognostic (1.67e-2)" "unprognostic (6.99e-3)" "unprognostic (1.04e-1)" "unprognostic (4.51e-2)" "unprognostic (3.36e-2)" "unprognostic (1.33e-1)" "unprognostic (5.67e-2)" "prognostic favorable (1.38e-4)" "unprognostic (1.09e-1)" "unprognostic (4.07e-2)" "unprognostic (3.60e-2)" "unprognostic (1.80e-1)" 14.4 21.4 133.9 12.4 138.4 1.8 25.4 152.5 216.5 9.9 94.3 19.6 175.5 8.4 10.5 25.1 11.6 47.7 57.2 131.1 140.9 2099.3 2804.2 7.3 18.4 148.0 135.4 165.2 2935.3 2.7 8.3 74.7 153.4 12.4 11.5 7.5 57.5 15.1 142.5 137.6 110.2 14.5 149.2 33.6 99.2 78.2 140.4 12.6 63.0 46.9 29.7 18.0 15.5 181.2 12.9 6.5 4.4 0.6 0.1 0.2 0.8 0.1 0.1 0.0 0.2 1.4 21.4 34.4 1.0 0.0 5.7 2.2 17.0 0.6 0.4 1.9 0.3 2.8 0.4 0.3 0.8 20.7 2.6 0.8 0.7 0.0 0.4 0.0 0.3 7.8 0.4 0.7 0.2 0.6 2.2 0.6 11.2 31.3 0.0 0.5 210.1 1.5 3.5 55.8 23.5 4.1 6.9 0.4 1.2 2.1 2.9 23.7 0.0 0.0 0.5 0.2 6.3 126.3 165.5 0.8 1.6 0.3 1.0 0.0 1.1 0.3 0.2 1.6 0.0 11.0 0.0 0.2 6.6 5.4 0.0 1.4 0.0 0.1 0.6 6.8 0.0 1.0 133.9 138.4 152.5 216.5 131.1 140.9 148.0 135.4 153.4 149.2 140.4 181.2 2.4 3.2 1.1 67.3 42.3 54.3 14.9 5.2 5.7 8.1 16.9 9.5 35.5 228.8 5.4 71.7 0.0 1.0 0.8 3.1 295.4 58.2 8.8 1.3 0.4 7.3 0.0 29.3 6.8 290.0 1.2 19.8 69.8 2.7 3.8 219.5 23.9 1495.2 89.6 8.4 3.3 3.1 2.0 80.3 80.3 18.3 4.4 50.6 23.2 20.6 3.1 19.1 2.1 57.3 196.3 97.3 3.9 3.4 7.2 6.4 98.4 3703.0 1.9 3.8 6.6 38.4 16.8 22.0 9.7 16.0 133.7 1.8 17.6 4.1 3.4 20.4 GBE1 ENSG00000114480 "1,4-alpha-glucan branching enzyme 1" Q04446 3 81489703-81761645 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Glycogen biosynthesis" "Glycosyltransferase, Transferase" "Disease variant, Glycogen storage disease, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 149.1" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "ASC diff: 287.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038073, HPA038074, HPA038075" Enhanced Approved Cytosol NA NA 6500000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "HPA038073: AB_10673040, HPA038074: AB_10672403, HPA038075: AB_10674545" "unprognostic (3.10e-1)" "unprognostic (1.02e-3)" "unprognostic (6.76e-2)" "unprognostic (1.05e-2)" "unprognostic (3.48e-2)" "unprognostic (1.89e-1)" "unprognostic (9.01e-3)" "unprognostic (1.17e-2)" "unprognostic (2.65e-1)" "unprognostic (1.50e-1)" "unprognostic (2.19e-2)" "unprognostic (5.68e-2)" "unprognostic (1.46e-1)" "unprognostic (5.36e-2)" "unprognostic (4.42e-1)" "unprognostic (2.83e-3)" "unprognostic (3.78e-3)" 73.9 53.8 4.5 14.9 5.7 19.7 38.6 7.1 8.2 14.2 14.2 11.8 13.2 17.3 14.2 18.1 13.8 13.0 55.6 6.2 8.2 41.4 108.6 17.2 8.6 10.7 18.7 14.2 14.2 19.1 10.4 25.6 10.3 13.2 13.8 22.0 15.5 14.9 149.1 14.4 11.5 21.8 7.0 12.0 11.1 7.9 7.4 11.4 19.6 56.6 13.2 19.2 13.9 7.4 61.3 36.2 11.9 168.7 287.6 216.8 21.5 99.1 140.1 58.1 97.6 7.1 15.6 67.9 42.7 122.5 34.5 7.1 9.9 45.7 135.4 32.3 6.4 21.2 70.0 22.8 197.5 72.2 17.8 161.2 33.2 93.5 95.5 144.9 130.5 8.0 17.0 38.0 191.1 17.8 12.5 92.7 12.0 16.8 58.0 22.9 53.6 81.1 41.4 20.5 6.0 7.9 64.6 18.7 20.9 17.2 13.3 58.9 183.4 118.9 28.1 84.7 92.8 174.8 21.4 24.6 194.1 47.8 49.8 7.5 11.8 15.6 5.2 10.8 5.1 11.6 5.6 5.7 13.8 12.5 6.4 6.6 11.4 13.5 11.8 4.8 5.1 6.5 4.5 5.7 7.1 8.2 6.2 8.2 10.7 18.7 10.3 7.0 7.4 7.4 49.7 16.0 12.4 31.3 14.9 30.7 22.2 36.8 27.3 18.6 7.5 5.5 60.2 15.7 21.9 31.3 0.0 30.3 8.4 9.5 41.1 32.1 36.2 16.3 15.2 32.0 22.1 4.6 52.4 25.4 74.0 34.9 6.6 14.7 43.1 16.0 15.4 75.2 26.3 30.3 47.4 8.7 12.2 12.9 21.3 16.9 17.4 17.3 24.9 87.1 16.3 10.4 7.2 49.3 63.0 37.8 5.8 13.2 12.8 17.7 11.3 50.8 25.0 17.8 32.9 45.8 26.7 6.9 7.3 20.6 21.3 54.9 8.7 34.2 8.3 14.5 GCAT KBL ENSG00000100116 "Glycine C-acetyltransferase" O75600 22 37807905-37817176 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "pancreas: 140.2" "Cell type enhanced" "Detected in many" "Distal tubular cells: 80.3;Hepatocytes: 66.1;Proximal tubular cells: 163.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020460, HPA063924" Approved Supported "Nucleoplasm,Nuclear speckles,Mitochondria" Yes No "Cluster 20: T-cells - T-cell receptor" "Cluster 22: Non-specific - Unknown function" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm "Nuclear speckles, Mitochondria" "HPA020460: AB_1849548, HPA063924: " "unprognostic (1.61e-1)" "unprognostic (1.80e-2)" "unprognostic (8.38e-2)" "unprognostic (1.05e-1)" "unprognostic (1.10e-2)" "unprognostic (4.17e-2)" "unprognostic (2.40e-1)" "unprognostic (1.37e-2)" "unprognostic (3.56e-2)" "unprognostic (2.76e-3)" "unprognostic (1.12e-1)" "unprognostic (2.51e-1)" "unprognostic (1.36e-3)" "unprognostic (8.00e-2)" "unprognostic (1.97e-1)" "unprognostic (4.73e-3)" "unprognostic (3.99e-1)" 6.6 15.7 25.1 3.2 24.8 14.1 6.5 26.2 33.3 6.3 22.5 7.3 4.9 7.8 3.0 17.0 6.0 5.0 43.4 26.1 25.0 13.0 53.3 5.6 2.8 25.9 27.4 9.0 140.2 6.0 9.7 2.7 27.8 22.8 4.9 2.2 13.3 6.8 19.5 8.1 5.4 4.2 24.4 1.5 13.2 10.3 27.9 4.3 16.0 19.1 3.1 7.1 7.0 24.6 18.7 4.7 11.9 68.2 24.0 19.4 8.4 25.9 26.9 19.2 16.3 10.5 2.1 5.8 11.8 11.7 11.3 10.6 11.9 18.3 4.3 2.6 21.9 12.9 15.0 42.5 39.0 23.0 16.4 22.8 10.9 12.7 27.7 6.2 16.0 23.0 33.2 6.6 9.2 16.2 24.3 42.3 5.0 28.8 19.0 25.2 2.5 34.4 24.6 14.3 24.5 16.7 20.0 32.3 13.9 4.2 25.8 11.1 11.8 19.3 10.6 12.9 9.2 21.9 11.5 12.1 13.3 21.1 20.5 0.1 0.6 0.4 0.7 0.7 0.3 0.1 1.6 0.5 1.3 0.0 3.5 1.4 0.3 1.3 0.4 1.3 1.7 1.4 25.1 24.8 26.2 33.3 26.1 25.0 25.9 27.4 27.8 24.4 27.9 24.6 3.5 6.4 15.4 9.8 2.8 7.8 18.5 11.2 12.5 8.9 18.6 17.4 54.6 11.5 9.4 11.0 4.2 15.7 0.7 13.1 80.3 7.2 4.1 9.9 8.1 5.5 2.4 22.7 5.0 10.3 19.6 9.8 15.3 16.7 8.9 17.6 5.0 66.1 4.7 8.4 4.7 32.3 8.2 2.9 1.3 7.7 3.7 2.1 21.4 1.0 1.0 25.1 1.0 6.6 4.1 5.4 8.7 9.8 2.0 19.1 8.6 163.8 6.4 2.2 6.6 4.8 30.1 12.6 33.2 19.6 6.0 27.8 3.0 27.8 24.0 14.4 GCK "HK4, MODY2" ENSG00000106633 Glucokinase P35557 7 44143213-44198170 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Glycolysis "Allosteric enzyme, Kinase, Transferase" "Diabetes mellitus, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "brain: 12.6;choroid plexus: 7.4;heart muscle: 8.8;liver: 21.5;pituitary gland: 23.9" "Cell type enhanced" "Detected in some" "Bipolar cells: 5.0;Cardiomyocytes: 4.9;Fibroblasts: 5.2;Horizontal cells: 5.0;Smooth muscle cells: 3.7" "Cancer enhanced" "Detected in some" "liver cancer: 4.0" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "memory B-cell: 2.3;naive CD4 T-cell: 2.0" "Low lineage specificity" "Detected in many" "Cell line enriched" "Detected in some" 5 "SCLC-21H: 6.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA007034, HPA007093" Approved Approved "Golgi apparatus,Cytosol" NA NA "Cluster 37: B-cells - Transcription" "Cluster 15: Liver - Metabolism" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 33: Fibroblasts - ECM organization" "Golgi apparatus, Cytosol" "HPA007034: AB_1079050, HPA007093: AB_1079051" "unprognostic (3.09e-1)" "unprognostic (2.99e-2)" "unprognostic (3.32e-2)" "unprognostic (6.64e-7)" "unprognostic (8.00e-2)" "unprognostic (2.75e-1)" "unprognostic (1.07e-2)" "unprognostic (2.68e-1)" "unprognostic (1.24e-1)" "unprognostic (5.48e-2)" "unprognostic (8.11e-3)" "unprognostic (3.08e-1)" "unprognostic (3.79e-3)" "unprognostic (2.01e-2)" "unprognostic (3.24e-1)" "unprognostic (4.36e-2)" "unprognostic (1.53e-1)" 0.8 0.3 8.9 0.3 8.3 0.2 0.7 8.1 9.5 2.8 7.4 0.5 0.1 1.2 0.8 0.4 1.2 0.5 8.8 8.2 11.0 1.2 21.5 0.4 0.2 9.0 9.9 1.4 1.8 0.1 23.9 1.6 9.1 1.2 0.2 1.0 0.3 0.7 0.2 0.7 0.5 0.3 8.3 0.6 0.6 0.4 12.6 0.1 0.5 0.1 0.2 1.1 2.0 7.9 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.1 0.3 0.2 0.0 0.0 0.0 0.1 0.7 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.3 0.5 0.0 0.7 0.0 0.0 0.1 0.4 0.0 0.0 0.0 0.1 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.6 1.2 1.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.7 0.1 0.0 0.6 0.0 0.2 0.2 0.1 0.0 0.1 0.0 0.3 2.3 0.7 0.1 0.1 0.3 2.0 0.4 0.8 0.1 0.0 0.1 0.0 0.3 8.9 8.3 8.1 9.5 8.2 11.0 9.0 9.9 9.1 8.3 12.6 7.9 0.3 0.0 0.0 0.7 0.3 1.1 0.7 0.0 1.2 5.0 0.1 0.8 4.9 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.1 0.0 1.3 0.5 2.4 0.0 1.8 0.0 0.2 5.2 0.0 0.0 0.0 2.4 0.0 0.4 0.7 5.0 2.4 0.0 0.0 0.0 0.7 0.3 0.9 0.1 0.0 1.0 0.0 2.8 0.0 0.5 1.0 0.1 0.1 2.2 0.2 1.7 0.0 0.1 0.0 0.8 0.0 0.6 3.7 0.5 1.1 0.0 0.1 0.8 0.3 0.5 0.0 0.7 GCNT1 "C2GNT, NACGT2, NAGCT2" ENSG00000187210 "Glucosaminyl (N-acetyl) transferase 1" Q02742 9 76419850-76651203 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "intestine: 49.9;parathyroid gland: 84.1;stomach 1: 39.0;thyroid gland: 21.5" "Cell type enhanced" "Detected in many" "Gastric mucus-secreting cells: 93.8;Kupffer cells: 42.2;Proximal enterocytes: 40.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in many" "eosinophil: 21.6" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HHSteC: 46.2;HSkMC: 39.4;U-2197: 33.9" "Group enriched" "Detected in all" 6 "cerebellum: 7.6;olfactory bulb: 24.9" "Low region specificity" "Detected in all" "HPA003522, HPA003523, HPA031151" Uncertain Supported "Nuclear speckles" NA NA 84000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 18: U-2197 - ECM organization" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Nuclear speckles" "HPA003522: , HPA003523: , HPA031151: AB_10602904" "unprognostic (3.14e-1)" "unprognostic (2.01e-1)" "unprognostic (2.19e-1)" "prognostic favorable (8.44e-4)" "unprognostic (5.53e-2)" "unprognostic (2.41e-1)" "unprognostic (1.65e-2)" "unprognostic (3.37e-2)" "unprognostic (2.40e-1)" "unprognostic (2.63e-1)" "unprognostic (1.90e-1)" "unprognostic (3.06e-1)" "unprognostic (3.02e-3)" "unprognostic (4.21e-1)" "unprognostic (2.00e-1)" "unprognostic (2.80e-1)" "prognostic unfavorable (4.96e-4)" 4.0 0.8 1.8 5.0 2.2 5.1 4.6 4.8 1.7 10.6 1.3 8.7 49.9 5.9 0.7 1.8 1.5 2.9 1.2 2.0 0.9 0.9 1.9 4.2 6.7 1.0 1.0 0.7 2.1 84.1 0.9 2.9 1.0 6.3 9.3 0.1 3.8 1.3 0.3 1.1 32.3 4.8 1.0 7.3 39.0 1.6 1.5 3.0 21.5 0.7 4.7 2.2 0.8 1.4 4.7 0.4 0.3 0.1 5.5 26.5 6.7 18.8 8.4 15.0 10.5 4.7 1.1 3.3 1.8 14.1 2.9 4.0 9.5 7.8 16.6 2.3 1.6 8.2 0.4 0.8 46.2 6.0 2.7 39.4 2.0 14.5 15.5 12.2 13.9 4.1 0.0 3.2 15.1 7.1 3.2 9.7 8.8 11.9 1.1 5.3 9.3 1.6 17.5 8.3 2.0 0.0 2.3 2.5 0.1 6.6 0.0 4.1 5.6 9.3 5.9 33.9 8.4 4.7 0.9 0.0 18.7 10.1 2.3 6.1 3.2 21.6 1.5 7.8 0.5 1.9 1.7 1.5 5.8 10.2 0.3 1.1 1.1 5.8 7.3 2.8 2.5 2.1 1.8 2.2 4.8 1.7 2.0 0.9 1.0 1.0 1.0 1.0 1.5 1.4 2.9 0.0 1.7 2.0 8.3 0.9 5.0 34.4 0.6 0.0 8.8 4.2 1.0 0.0 15.6 3.7 0.0 2.1 10.7 16.6 0.0 1.0 20.1 15.1 4.2 5.1 27.6 17.9 11.8 24.3 27.1 3.4 93.8 24.6 10.8 0.6 6.4 0.3 8.1 0.0 1.7 21.3 16.2 42.2 8.5 12.9 0.0 18.6 1.8 15.0 6.7 0.1 8.2 0.5 0.8 12.9 14.5 1.2 2.2 6.8 40.7 1.4 17.0 0.4 0.0 0.9 1.8 1.8 3.3 1.0 0.3 19.0 10.6 0.2 38.4 1.5 GCNT2 "bA360O19.2, bA421M1.1, CCAT, GCNT5, IGNT, II, NACGT1, NAGCT1, ULG3" ENSG00000111846 "Glucosaminyl (N-acetyl) transferase 2 (I blood group)" Q8N0V5 6 10492223-10629368 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "prostate: 13.5" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 76.9;Endometrial ciliated cells: 79.1;Glandular and luminal cells: 105.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in some" "basophil: 1.9" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "EFO-21: 44.2;Hep G2: 19.7;SK-MEL-30: 17.1;SuSa: 21.4" "Region enriched" "Detected in all" 4 "basal ganglia: 61.1" "Low region specificity" "Detected in all" HPA026776 Approved Approved "Golgi apparatus" No No 750000 "Cluster 41: Basophils - Cellular respiration" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 38: EFO-21 - Unknown function" "Cluster 44: Endometrium - Transcription" "Golgi apparatus" "HPA026776: AB_1849573" "unprognostic (2.47e-1)" "unprognostic (6.87e-3)" "unprognostic (3.12e-1)" "unprognostic (1.42e-2)" "unprognostic (9.31e-2)" "unprognostic (2.51e-1)" "unprognostic (4.11e-2)" "unprognostic (2.39e-1)" "unprognostic (1.27e-1)" "unprognostic (2.11e-2)" "unprognostic (6.28e-4)" "unprognostic (3.96e-2)" "unprognostic (1.58e-3)" "unprognostic (6.54e-2)" "unprognostic (6.32e-2)" "unprognostic (1.13e-1)" "unprognostic (1.53e-1)" 0.6 0.3 0.7 1.0 0.6 0.3 10.1 2.5 1.1 4.2 4.5 3.6 5.2 1.4 0.2 1.4 0.8 1.5 6.6 0.8 1.1 5.7 5.1 3.9 1.8 1.2 1.0 0.3 1.3 0.4 1.4 2.6 1.4 13.5 2.0 0.3 4.2 0.3 0.7 1.4 5.8 1.6 0.9 1.5 5.9 2.5 0.9 0.5 1.2 1.8 2.4 1.0 0.7 1.0 6.3 4.9 1.5 4.8 0.0 0.0 9.6 0.0 4.1 1.1 0.5 11.0 5.2 3.5 44.2 0.0 3.2 0.3 0.4 5.1 2.9 3.1 1.8 0.5 2.6 19.7 0.0 1.7 4.7 0.0 0.0 0.5 0.0 2.4 9.1 0.0 0.4 0.0 0.4 0.0 0.0 4.0 4.4 0.0 3.6 0.2 3.8 6.0 16.0 2.9 4.0 1.2 0.0 14.4 17.1 21.4 0.3 0.8 6.4 0.8 0.5 0.0 5.0 0.1 0.0 2.4 0.8 0.3 2.3 1.9 1.1 0.5 0.1 0.8 0.0 0.7 0.1 0.1 0.8 0.4 0.1 0.2 0.1 0.2 0.2 0.2 0.0 0.3 0.7 0.6 2.5 1.1 0.8 1.1 1.2 1.0 1.4 0.9 0.9 1.0 1.4 76.9 32.4 1.0 9.5 4.6 6.6 15.5 9.6 5.1 30.5 16.1 18.4 2.8 28.6 7.3 0.0 27.9 6.4 15.5 11.7 2.9 4.3 79.1 5.5 11.0 2.4 25.9 0.7 24.7 2.1 2.0 16.8 105.5 2.5 0.0 12.8 32.0 15.8 3.3 11.8 5.6 6.1 7.7 9.4 8.2 0.3 7.8 49.8 52.5 11.1 2.4 0.0 18.6 1.1 12.0 11.9 0.0 1.0 16.6 44.3 13.4 27.9 0.6 0.0 0.7 2.2 6.2 27.6 11.2 1.7 10.9 3.1 0.0 16.3 8.1 GCNT3 "C2/4GnT, C2GnT-M, C2GnT2" ENSG00000140297 "Glucosaminyl (N-acetyl) transferase 3, mucin type" O95395 15 59594875-59640239 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "gallbladder: 75.5;intestine: 142.9;salivary gland: 55.8" "Cell type enhanced" "Detected in many" "Collecting duct cells: 104.8;Distal enterocytes: 360.1;Ductal cells: 92.6;Glandular and luminal cells: 75.6;Paneth cells: 163.2;Proximal enterocytes: 85.5" "Group enriched" "Detected in many" 4 "colorectal cancer: 16.4;pancreatic cancer: 29.8;stomach cancer: 20.1" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 147.4;EFO-21: 24.6;Hep G2: 30.3;OE19: 75.9" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA011154 Enhanced Approved "Golgi apparatus,Vesicles" NA NA "Cluster 17: Basophils - Unknown function" "Cluster 9: Intestine - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 53: Intestinal epithelial cells - Unknown function" "Golgi apparatus" Vesicles "HPA011154: AB_1078961" "unprognostic (5.09e-2)" "unprognostic (2.39e-1)" "unprognostic (5.92e-2)" "prognostic favorable (1.78e-4)" "unprognostic (3.99e-3)" "unprognostic (2.02e-2)" "prognostic unfavorable (6.49e-5)" "unprognostic (1.69e-1)" "unprognostic (1.31e-1)" "unprognostic (2.34e-1)" "unprognostic (1.64e-2)" "unprognostic (1.63e-1)" "unprognostic (4.02e-3)" "unprognostic (1.48e-1)" "unprognostic (1.06e-2)" "unprognostic (4.65e-2)" "unprognostic (2.43e-1)" 0.2 0.7 0.2 11.9 0.2 0.5 0.4 0.6 0.4 19.2 0.2 142.9 97.5 2.0 0.0 15.8 4.2 75.5 0.1 0.2 0.1 17.9 0.4 0.7 0.9 0.1 0.4 0.1 2.1 0.9 0.1 0.1 0.2 1.2 123.2 0.1 55.8 0.3 0.2 0.3 123.3 4.6 0.0 0.1 25.8 4.3 0.2 1.3 2.1 0.0 10.6 9.1 29.9 0.4 0.1 147.4 0.0 0.2 0.0 1.0 0.2 0.1 7.7 0.0 0.0 6.3 6.0 0.6 24.6 0.0 9.5 0.5 0.0 0.0 0.0 0.5 0.1 0.0 0.5 30.3 0.0 0.2 0.2 0.3 3.5 0.7 0.0 0.1 0.0 0.2 0.0 0.4 1.4 0.6 0.1 0.2 0.2 75.9 0.3 0.4 0.0 0.6 10.2 1.2 0.2 0.2 0.0 0.2 0.4 0.1 0.1 0.0 0.1 0.2 0.4 7.3 0.1 0.2 0.5 0.8 8.9 0.3 0.1 0.9 0.1 0.1 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.2 0.0 0.1 0.7 0.2 0.1 0.3 0.1 0.0 0.2 0.2 0.6 0.4 0.2 0.1 0.1 0.4 0.2 0.0 0.2 0.4 0.0 0.0 2.2 0.0 1.0 0.0 18.3 8.9 0.0 0.0 0.5 0.0 0.7 11.5 40.5 104.8 0.0 0.0 0.1 360.1 0.0 92.6 9.8 23.3 8.6 0.3 7.8 0.0 0.0 14.9 0.0 0.2 27.5 75.6 0.0 0.0 0.0 0.2 0.1 0.0 0.0 26.9 8.2 0.6 0.0 19.2 0.0 0.5 0.0 0.0 1.0 0.0 0.0 0.0 0.0 58.4 163.2 0.0 0.1 8.0 85.5 4.4 9.8 0.0 6.6 0.6 1.5 3.0 0.3 1.4 0.0 0.0 0.8 0.0 48.5 52.4 GCNT4 "C2GNT3, LINC01336" ENSG00000176928 "Glucosaminyl (N-acetyl) transferase 4" Q9P109 5 75025346-75052558 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 24.0;lymphoid tissue: 15.4;stomach 1: 18.5" "Cell type enhanced" "Detected in many" "Cholangiocytes: 32.9;Cytotrophoblasts: 39.6;Glandular and luminal cells: 16.7;Proximal enterocytes: 28.0;Syncytiotrophoblasts: 24.4" "Low cancer specificity" "Detected in many" "Group enriched" "Detected in many" 20 "amygdala: 1.1;basal ganglia: 1.8;cerebral cortex: 3.3;hippocampal formation: 2.1;white matter: 1.4" "Immune cell enhanced" "Detected in many" "basophil: 22.4" "Group enriched" "Detected in many" 53 "granulocytes: 22.4;T-cells: 18.2" "Cell line enriched" "Detected in some" 5 "RT4: 37.1" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA037431 Approved Supported "Nucleoplasm,Golgi apparatus" No NA "Cluster 20: T-cells - T-cell receptor" "Cluster 56: Intestine - Transmembrane transport" "Cluster 15: RT4 - Unknown function" "Cluster 47: Cytotrophoblasts - Unknown function" "Golgi apparatus" Nucleoplasm "HPA037431: AB_10670382" "unprognostic (1.88e-2)" "unprognostic (5.63e-2)" "unprognostic (6.05e-2)" "unprognostic (1.28e-1)" "unprognostic (1.12e-1)" "unprognostic (4.98e-2)" "unprognostic (4.11e-3)" "unprognostic (1.63e-2)" "unprognostic (3.47e-1)" "unprognostic (2.20e-2)" "unprognostic (4.49e-3)" "unprognostic (6.04e-2)" "prognostic favorable (1.93e-7)" "unprognostic (8.39e-2)" "unprognostic (1.93e-1)" "unprognostic (6.06e-2)" "unprognostic (5.82e-2)" 0.9 0.8 1.1 2.9 1.8 0.7 1.3 0.0 3.3 1.4 0.0 1.4 24.0 1.2 1.9 2.2 2.1 5.3 0.4 2.1 0.0 4.1 1.1 1.7 4.4 0.0 0.0 1.0 4.6 9.6 0.2 6.3 0.0 1.7 1.3 0.1 0.5 4.8 1.0 2.1 20.2 2.3 0.0 1.7 18.5 1.6 0.0 15.4 0.5 1.4 3.0 4.1 1.8 1.4 0.3 0.2 1.4 2.3 2.5 0.8 0.1 2.8 7.2 1.5 1.2 3.7 0.2 0.0 0.4 2.2 0.8 1.0 1.4 2.5 0.3 0.0 0.1 1.2 0.3 0.3 1.1 0.0 0.0 0.4 3.9 0.1 0.5 0.0 0.0 2.2 0.0 0.5 0.2 0.0 2.1 0.1 0.6 8.0 0.0 0.0 0.0 3.6 0.3 37.1 0.0 0.1 0.3 0.0 0.1 7.0 0.0 0.0 0.0 0.8 0.2 1.0 0.1 0.0 0.0 0.0 0.5 0.0 0.1 22.4 0.0 0.0 1.2 0.0 5.0 0.0 11.4 3.7 0.0 0.0 11.1 8.1 0.2 0.3 0.2 0.1 18.2 2.3 1.1 1.8 0.0 3.3 2.1 0.0 0.0 0.0 0.0 0.0 0.0 1.4 1.2 3.2 5.0 0.7 0.3 0.6 8.7 0.5 0.0 0.0 0.9 2.3 0.5 32.9 2.7 12.9 0.0 39.6 0.8 4.9 9.8 7.1 0.1 11.9 2.4 1.8 0.0 0.0 1.3 4.4 0.9 2.5 14.8 16.7 7.6 2.0 3.3 0.7 2.3 0.0 0.0 2.7 0.0 0.3 0.0 0.3 4.1 0.2 0.0 0.0 0.7 0.0 0.0 0.0 0.0 5.2 6.9 2.6 0.5 3.0 28.0 0.7 0.6 0.0 6.6 1.6 2.5 0.2 1.7 0.6 0.1 24.4 3.7 0.0 4.4 4.2 GDPGP1 C15orf58 ENSG00000183208 "GDP-D-glucose phosphorylase 1" Q6ZNW5 15 90233808-90245811 "Enzymes, Predicted intracellular proteins" "Guanine-nucleotide releasing factor, Hydrolase, Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "HPA048189, HPA059841" Approved Approved Cytosol NA NA "Cluster 24: B-cells - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 6: T47d - Mammary gland" "Cluster 1: Pancreatic cells - Digestion" Cytosol "HPA048189: AB_2680307, HPA059841: AB_2684138" "prognostic favorable (6.32e-4)" "unprognostic (1.85e-1)" "unprognostic (2.17e-1)" "unprognostic (2.42e-2)" "unprognostic (2.14e-1)" "unprognostic (1.18e-1)" "unprognostic (1.18e-1)" "unprognostic (2.58e-1)" "unprognostic (3.68e-2)" "unprognostic (4.46e-3)" "unprognostic (1.53e-1)" "unprognostic (3.00e-1)" "unprognostic (1.82e-2)" "unprognostic (2.93e-3)" "unprognostic (8.43e-2)" "unprognostic (1.87e-1)" "unprognostic (1.02e-3)" 1.8 3.2 3.9 3.0 3.0 2.0 2.3 4.3 4.2 2.0 3.1 5.7 5.3 2.2 3.0 2.4 4.6 3.0 5.8 3.2 2.9 4.3 4.9 2.9 3.5 3.7 2.9 2.9 3.5 4.9 3.7 1.0 4.6 3.7 7.7 2.7 3.8 3.1 7.9 2.1 3.9 2.8 1.8 3.2 3.5 4.6 2.9 3.1 3.8 1.5 4.1 3.4 1.5 5.0 3.0 11.8 1.4 4.3 4.3 0.9 3.9 2.7 1.7 3.5 3.3 3.5 11.5 7.5 5.2 2.1 2.6 5.0 4.5 3.2 1.4 6.7 7.8 6.7 7.0 5.1 4.6 3.6 4.2 1.1 2.1 2.4 1.3 3.9 4.2 4.4 2.5 2.6 2.1 6.5 2.7 1.6 1.8 9.2 4.8 4.7 1.0 3.8 4.1 5.9 4.5 2.0 4.3 6.6 4.5 2.6 7.6 3.7 4.2 1.8 1.9 2.7 2.7 5.8 7.3 3.4 4.1 3.0 3.3 3.8 2.2 1.0 3.1 2.6 2.7 2.3 2.9 3.7 2.0 4.2 3.0 2.8 3.1 3.4 2.2 2.1 3.9 1.4 3.9 3.0 4.3 4.2 3.2 2.9 3.7 2.9 4.6 1.8 2.9 5.0 1.4 0.0 3.2 0.3 2.1 0.0 2.8 0.9 1.8 3.8 3.4 2.2 6.4 8.6 1.5 7.3 6.2 2.4 2.5 6.5 3.9 3.8 3.0 3.8 1.6 1.7 5.4 1.7 2.6 6.0 1.2 1.5 4.1 2.3 3.8 2.3 1.4 4.5 4.1 1.7 2.8 3.6 0.0 2.2 0.0 2.4 2.8 3.5 0.0 1.0 2.3 3.5 2.1 1.0 2.1 4.9 5.5 2.2 2.4 2.2 3.8 5.8 3.4 4.4 0.0 3.8 1.0 2.9 2.8 1.8 0.3 0.4 3.2 1.5 4.2 3.1 GFPT1 "GFA, GFAT, GFAT1, GFPT" ENSG00000198380 "Glutamine--fructose-6-phosphate transaminase 1" Q06210 2 69319780-69387250 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Biological rhythms" "Aminotransferase, Transferase" "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal enterocytes: 184.2;Intestinal goblet cells: 244.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA047240 Approved "Nucleoplasm,Nucleoli,Nucleoli fibrillar center" NA NA 93000 "Cluster 46: Basophils - DNA binding" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 30: Epithelial cell lines - Translation" "Cluster 27: Mucus-secreting cells - Mucin production" "Nucleoplasm, Nucleoli" "Nucleoli fibrillar center" "HPA047240: " "unprognostic (4.38e-3)" "unprognostic (8.20e-2)" "prognostic favorable (7.13e-5)" "unprognostic (2.97e-1)" "unprognostic (1.32e-1)" "unprognostic (2.40e-2)" "unprognostic (1.08e-2)" "unprognostic (2.11e-1)" "unprognostic (2.99e-1)" "unprognostic (3.14e-1)" "unprognostic (4.84e-2)" "unprognostic (5.00e-2)" "unprognostic (3.83e-2)" "unprognostic (9.49e-2)" "unprognostic (1.78e-1)" "unprognostic (1.63e-1)" "unprognostic (2.58e-1)" 31.2 17.9 6.6 21.5 6.5 15.0 22.4 5.5 7.1 37.8 31.5 74.3 38.4 15.6 41.6 16.4 24.3 32.5 24.8 7.0 11.0 21.6 23.1 17.0 10.6 4.9 10.5 12.0 33.7 26.2 18.9 36.0 10.8 36.7 76.6 10.4 42.4 25.9 10.2 6.0 41.2 23.2 5.3 9.5 64.3 46.6 8.0 10.2 91.8 13.9 15.9 21.8 9.2 6.8 46.6 42.7 34.7 20.9 107.7 75.8 73.5 97.1 94.5 44.7 59.3 109.5 50.5 31.7 31.9 92.9 61.4 22.6 47.1 28.6 73.6 38.4 18.4 38.2 25.0 94.5 123.0 27.9 17.9 47.8 132.5 88.7 158.8 55.5 43.4 29.8 34.8 58.3 85.2 30.9 31.3 22.9 37.0 116.7 27.4 28.2 79.1 18.3 70.6 42.0 25.2 11.9 35.2 52.4 93.7 73.5 22.7 17.2 61.8 37.2 62.3 64.6 47.5 39.5 32.2 25.4 65.7 18.3 46.9 9.2 3.5 4.9 7.5 4.3 7.0 6.4 6.5 8.3 4.7 3.6 6.3 6.2 1.2 5.2 5.2 4.4 5.0 4.2 6.6 6.5 5.5 7.1 7.0 11.0 4.9 10.5 10.8 5.3 8.0 6.8 14.6 51.3 49.5 15.7 29.8 28.4 21.6 31.7 26.7 13.7 50.6 16.5 43.1 42.9 54.5 44.1 12.5 28.6 30.3 184.2 17.6 34.1 123.9 54.4 54.1 17.2 75.1 3.8 49.2 89.5 70.3 37.6 110.1 60.0 24.1 19.2 17.9 53.6 17.0 6.7 56.3 244.0 16.2 10.0 31.4 23.7 23.3 16.0 53.4 27.2 28.1 10.6 13.4 42.7 43.8 66.0 83.3 28.2 82.1 72.3 62.5 30.0 89.7 14.0 19.7 21.6 41.8 134.1 45.3 20.3 21.0 34.3 33.4 15.7 135.3 56.3 GFPT2 GFAT2 ENSG00000131459 "Glutamine-fructose-6-phosphate transaminase 2" O94808 5 180300698-180353336 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Aminotransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 112.4" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 30.4;Fibroblasts: 77.9;Skeletal myocytes: 27.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "MAIT T-cell: 3.5" "Lineage enriched" "Detected in single" 35 "T-cells: 3.5" "Cell line enhanced" "Detected in many" "ASC diff: 119.1;ASC TERT1: 202.3;GAMG: 152.5;HSkMC: 130.7;hTEC/SVTERT24-B: 248.0;U-87 MG: 426.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA056892, HPA059910" Uncertain Approved Vesicles NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 57: Non-specific - Angiogenesis" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 50: Fibroblasts - ECM organization" Vesicles "HPA056892: AB_2683266, HPA059910: AB_2684157" "unprognostic (3.48e-1)" "prognostic unfavorable (9.09e-4)" "unprognostic (1.91e-2)" "unprognostic (1.08e-2)" "unprognostic (6.28e-2)" "unprognostic (3.39e-3)" "unprognostic (3.05e-1)" "prognostic unfavorable (2.95e-4)" "unprognostic (7.65e-2)" "unprognostic (2.73e-2)" "unprognostic (4.50e-2)" "unprognostic (2.94e-2)" "prognostic unfavorable (2.58e-14)" "unprognostic (3.67e-3)" "unprognostic (1.23e-2)" "prognostic unfavorable (3.47e-4)" "unprognostic (1.52e-3)" 112.4 7.0 14.2 18.6 14.8 0.1 23.0 19.7 17.6 24.8 14.1 18.0 1.6 15.9 7.7 5.7 35.8 16.4 27.8 14.9 16.8 6.8 2.1 25.2 2.8 27.8 15.7 33.4 12.4 4.6 5.1 6.5 21.5 15.6 3.2 2.9 7.1 8.2 4.6 8.4 11.3 11.3 16.8 1.9 14.6 8.6 15.7 1.2 10.8 7.1 3.5 38.3 17.9 20.4 0.1 27.7 21.5 28.0 119.1 202.3 2.3 3.5 0.7 2.3 0.8 0.7 0.1 0.0 1.4 23.2 152.5 0.4 11.8 0.2 1.4 2.6 4.2 0.0 13.7 0.0 49.4 0.0 0.2 130.7 1.0 248.0 0.7 41.7 40.7 1.0 0.0 0.4 107.7 4.2 0.1 0.0 45.7 0.3 12.3 0.6 0.2 0.0 0.0 0.0 1.0 1.6 43.0 0.8 1.4 25.0 1.9 0.3 19.5 67.9 10.7 44.3 52.2 0.1 0.1 0.0 426.7 0.0 1.5 0.0 0.0 0.0 0.7 0.0 3.5 0.0 0.3 1.2 0.0 0.0 0.3 0.5 0.0 0.0 0.0 0.0 0.0 0.1 14.2 14.8 19.7 17.6 14.9 16.8 27.8 15.7 21.5 16.8 15.7 20.4 4.1 3.2 4.8 13.4 0.8 7.4 0.4 0.2 3.4 0.0 3.2 6.3 3.0 5.7 3.2 1.8 0.0 1.1 3.5 0.4 1.9 1.0 5.7 2.0 30.4 1.9 0.0 0.0 20.0 0.8 0.5 77.9 6.6 1.9 1.3 0.4 1.4 0.0 0.5 0.0 12.1 0.5 0.0 0.3 9.6 3.5 10.2 1.7 8.8 4.7 0.0 6.1 0.0 10.6 6.5 0.4 0.0 18.8 2.5 1.7 0.0 0.4 1.5 0.1 0.0 27.3 17.6 10.1 8.3 1.7 4.3 2.7 8.9 0.0 0.1 0.6 GGPS1 GGPPS1 ENSG00000152904 "Geranylgeranyl diphosphate synthase 1" O95749 1 235327350-235344532 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Isoprene biosynthesis" Transferase "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 212.7;Late spermatids: 290.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029472, HPA050727" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 21: Non-specific - Transcription" "Cluster 43: THP-1 - Innate immune response" "Cluster 25: Spermatids - Spermatogenesis" Cytosol Nucleoplasm "HPA029472: AB_10696206, HPA050727: " "unprognostic (7.45e-2)" "unprognostic (3.18e-2)" "unprognostic (1.25e-1)" "unprognostic (2.23e-2)" "unprognostic (1.43e-1)" "unprognostic (3.10e-3)" "prognostic unfavorable (6.69e-4)" "unprognostic (4.50e-2)" "unprognostic (3.66e-2)" "unprognostic (3.77e-3)" "unprognostic (2.66e-2)" "unprognostic (8.77e-3)" "unprognostic (1.95e-2)" "unprognostic (1.99e-1)" "unprognostic (3.35e-2)" "unprognostic (1.41e-1)" "unprognostic (1.70e-2)" 24.0 23.5 20.4 17.3 21.4 7.8 34.1 23.0 27.6 24.5 18.5 24.8 21.2 23.3 30.4 22.4 21.2 20.0 23.5 21.1 22.5 27.8 21.7 20.1 21.3 21.8 20.6 23.3 16.4 21.1 17.6 19.2 22.3 29.4 23.9 38.8 31.2 19.7 29.8 20.3 20.6 25.7 22.3 20.5 20.4 48.2 20.9 27.6 27.4 28.9 21.9 23.6 17.0 25.7 41.3 22.3 54.5 41.5 41.7 59.9 20.5 36.2 50.7 23.6 33.1 17.5 64.5 28.1 51.3 40.6 38.1 33.5 29.4 37.8 31.2 28.8 54.4 24.0 19.7 29.9 46.9 30.0 19.7 39.3 66.5 32.2 43.0 41.8 42.5 46.2 58.5 24.7 31.5 24.6 37.0 35.7 46.4 109.9 11.5 22.6 17.3 32.6 66.2 22.4 43.3 59.8 27.3 61.5 54.7 20.1 76.7 46.5 35.9 27.9 20.8 47.6 34.7 42.0 55.8 34.3 35.4 33.3 51.4 43.7 31.0 48.5 31.5 37.3 32.1 38.6 39.5 33.8 30.4 32.8 36.2 33.4 27.8 31.9 54.2 25.2 42.5 36.8 20.4 21.4 23.0 27.6 21.1 22.5 21.8 20.6 22.3 22.3 20.9 25.7 18.3 32.1 34.5 16.3 27.2 39.9 60.4 64.6 27.9 32.1 29.1 22.4 24.5 17.2 39.5 20.2 43.8 30.7 24.1 21.4 72.4 37.5 212.7 16.8 15.1 29.4 17.4 12.0 26.5 28.3 43.7 31.0 14.3 12.9 24.6 16.4 28.9 13.0 26.8 48.8 25.7 26.1 69.2 26.9 49.0 290.7 35.8 24.3 67.6 20.6 36.7 55.4 36.0 15.6 23.2 31.8 23.3 35.0 8.5 65.6 29.3 61.3 30.4 51.2 26.3 26.1 32.5 111.6 50.0 18.7 40.6 47.1 33.0 30.9 22.7 55.9 GGT1 "CD224, D22S672, D22S732, GGT" ENSG00000100031 "Gamma-glutamyltransferase 1" P19440 22 24594811-24629005 "Candidate cardiovascular disease genes, CD markers, Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Glutathione biosynthesis, Lipid metabolism" "Acyltransferase, Hydrolase, Protease, Transferase" "Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "kidney: 174.8;liver: 115.7" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 80.1;Cholangiocytes: 48.6;Distal enterocytes: 54.1;Ductal cells: 82.6;Hepatocytes: 40.8;Proximal enterocytes: 111.7;Proximal tubular cells: 62.9" "Cancer enhanced" "Detected in all" "renal cancer: 37.2" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HDLM-2: 103.6;Karpas-707: 165.8;OE19: 169.5;RPMI-8226: 210.3;RPTEC TERT1: 203.2" "HPA045635, HPA047534, HPA065444" Supported Uncertain Vesicles "Intracellular and membrane" NA NA 3600000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 21: OE19 - Mitochondria" "Cluster 45: Enterocytes - Digestion" Vesicles "HPA045635: AB_2679400, HPA047534: AB_2680079, HPA065444: AB_2685491" "unprognostic (8.13e-3)" "unprognostic (4.76e-1)" "unprognostic (8.29e-2)" "unprognostic (1.28e-2)" "unprognostic (3.70e-2)" "unprognostic (1.43e-2)" "unprognostic (5.60e-3)" "unprognostic (1.68e-1)" "unprognostic (2.21e-1)" "prognostic favorable (7.44e-4)" "unprognostic (4.55e-2)" "unprognostic (2.55e-2)" "prognostic favorable (4.83e-4)" "unprognostic (1.44e-2)" "unprognostic (5.37e-2)" "unprognostic (1.74e-1)" "unprognostic (6.10e-2)" 3.3 2.4 5.5 6.4 6.7 12.0 24.7 7.0 7.5 28.7 5.1 20.3 84.7 3.0 72.0 3.3 3.3 47.1 7.2 5.1 5.1 174.8 115.7 42.6 5.4 7.2 6.6 3.2 63.1 0.2 5.5 2.4 7.8 48.8 11.0 1.6 9.9 21.6 1.9 4.1 80.4 2.2 5.9 13.3 31.3 18.4 7.1 6.5 15.9 0.4 6.2 5.7 4.3 9.2 1.0 79.7 1.0 0.3 0.0 0.5 2.2 0.5 1.7 0.8 1.0 11.7 18.3 1.0 16.2 0.1 14.8 11.0 6.2 0.8 0.5 103.6 12.3 0.6 40.8 64.3 5.5 1.5 33.2 2.1 0.9 2.5 1.7 1.4 0.5 19.0 8.4 165.8 1.0 1.7 1.6 52.4 6.4 169.5 0.7 0.7 6.8 210.3 203.2 2.9 0.5 1.2 0.4 33.3 0.8 22.2 32.4 39.6 6.4 10.6 9.3 46.6 0.9 48.2 18.4 0.7 19.0 58.7 0.5 4.8 12.3 0.2 1.0 6.0 2.9 2.2 5.0 2.4 6.5 0.2 0.6 1.4 15.9 4.9 4.0 0.1 6.5 5.6 5.5 6.7 7.0 7.5 5.1 5.1 7.2 6.6 7.8 5.9 7.1 9.2 0.2 80.1 22.8 3.3 2.8 0.8 0.1 0.3 4.6 0.5 5.9 2.3 0.7 48.6 4.9 1.8 0.0 1.4 0.7 54.1 1.9 82.6 1.8 1.2 0.6 0.7 1.2 5.3 4.4 8.1 0.4 3.9 15.3 5.1 5.7 0.1 1.8 40.8 4.9 0.0 4.1 4.4 4.1 2.5 1.7 6.7 0.0 2.9 1.8 1.0 5.8 2.5 0.0 1.5 5.7 20.9 20.1 0.4 12.8 2.0 111.7 62.9 1.6 0.1 0.0 0.1 1.0 0.6 0.8 0.4 0.4 0.8 4.0 0.0 6.5 0.1 GGT5 "GGT-REL, GGTLA1" ENSG00000099998 "Gamma-glutamyltransferase 5" P36269 22 24219654-24245108 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glutathione biosynthesis, Leukotriene biosynthesis" "Acyltransferase, Hydrolase, Protease, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Endothelial cells: 42.8;Fibroblasts: 58.3;Leydig cells: 36.4;Sertoli cells: 184.1;Smooth muscle cells: 85.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "basophil: 2.3;eosinophil: 4.5" "Lineage enriched" "Detected in single" 8 "granulocytes: 4.5" "Cell line enhanced" "Detected in many" "ASC diff: 164.9;ASC TERT1: 124.4;HHSteC: 234.7;HSkMC: 271.7;TIME: 110.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA008121, CAB032489" Uncertain Approved "Nucleoli fibrillar center" "Intracellular and membrane" NA NA 22000000 "Cluster 52: Eosinophils - Transcription" "Cluster 72: Non-specific - Transcription" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 48: Smooth muscle cells - ECM organization" "Nucleoli fibrillar center" "CAB032489: AB_2111010, HPA008121: AB_1078965" "unprognostic (8.14e-2)" "unprognostic (2.53e-1)" "unprognostic (5.66e-2)" "unprognostic (9.94e-2)" "unprognostic (8.13e-2)" "unprognostic (8.21e-2)" "unprognostic (2.33e-2)" "unprognostic (2.90e-1)" "unprognostic (1.81e-2)" "unprognostic (1.07e-1)" "unprognostic (8.37e-2)" "unprognostic (7.94e-2)" "prognostic unfavorable (6.36e-5)" "prognostic unfavorable (4.06e-4)" "prognostic unfavorable (6.97e-4)" "unprognostic (1.79e-1)" "unprognostic (8.33e-2)" 137.6 60.5 39.0 18.6 39.3 1.4 90.6 37.6 41.7 73.2 32.8 27.8 19.4 54.4 12.9 19.6 70.6 37.2 93.4 35.0 45.1 78.2 55.2 37.7 48.0 52.2 46.3 26.6 25.8 13.2 41.1 11.9 46.9 49.3 12.0 2.1 37.1 20.9 23.1 40.1 40.8 32.2 41.9 36.1 40.0 9.6 45.3 10.4 110.2 16.6 18.3 45.1 64.2 38.2 0.0 1.8 0.6 0.0 164.9 124.4 1.1 2.9 0.2 0.1 0.0 0.1 0.1 0.2 3.4 0.2 0.3 0.3 0.1 0.1 0.0 2.2 0.9 6.7 1.0 24.1 234.7 3.0 6.4 271.7 0.1 3.4 3.2 0.4 45.8 0.7 0.4 1.2 44.1 0.4 0.0 22.4 3.6 1.1 0.0 0.1 4.0 1.0 6.1 0.0 0.4 5.9 0.1 7.3 0.1 22.7 1.0 1.7 110.8 0.1 2.3 0.1 0.0 0.3 1.5 0.2 3.9 5.7 0.2 2.3 0.5 4.5 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 1.1 0.4 0.0 0.0 0.0 0.2 39.0 39.3 37.6 41.7 35.0 45.1 52.2 46.3 46.9 41.9 45.3 38.2 27.2 3.2 16.0 1.0 0.3 7.0 3.3 3.2 0.0 0.0 7.2 4.2 4.4 0.0 17.9 0.0 0.0 0.2 0.4 0.0 0.0 0.6 0.8 0.3 8.3 42.8 0.0 2.7 0.1 0.2 0.2 58.3 1.1 0.4 1.3 0.0 33.5 0.1 2.1 0.0 0.1 0.0 0.0 1.0 12.5 3.3 36.4 1.8 3.6 22.5 3.3 0.3 0.0 0.5 0.0 0.4 0.0 23.7 0.3 2.2 0.0 0.1 2.2 1.0 184.1 33.9 85.6 0.6 0.4 0.3 4.4 0.3 1.1 2.1 0.0 1.4 GGT6 FLJ90165 ENSG00000167741 "Gamma-glutamyltransferase 6" Q6P531 17 4556927-4560818 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glutathione biosynthesis" "Acyltransferase, Hydrolase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 53.8;intestine: 53.4;salivary gland: 55.8;skin 1: 56.2" "Cell type enhanced" "Detected in many" "Distal enterocytes: 208.5;Intestinal goblet cells: 69.4;Paneth cells: 135.8;Proximal enterocytes: 130.9;Undifferentiated cells: 86.1" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 7 "RT4: 58.5;SK-BR-3: 19.4;T-47d: 60.5" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA023362, HPA027213" Approved NA NA 72000 "Cluster 6: Non-specific - Transcription" "Cluster 24: Salivary gland - Salivary secretion" "Cluster 6: T47d - Mammary gland" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA023362: AB_1848955, HPA027213: AB_10601326" "unprognostic (2.23e-2)" "unprognostic (1.20e-2)" "unprognostic (2.14e-3)" "unprognostic (4.51e-2)" "unprognostic (9.71e-2)" "unprognostic (7.67e-3)" "unprognostic (1.29e-1)" "prognostic favorable (4.35e-4)" "unprognostic (2.10e-1)" "unprognostic (2.33e-1)" "unprognostic (3.07e-2)" "unprognostic (5.06e-2)" "prognostic favorable (9.42e-7)" "unprognostic (1.56e-1)" "unprognostic (5.71e-2)" "unprognostic (9.17e-2)" "unprognostic (8.07e-3)" 0.3 0.6 0.4 5.0 0.5 0.2 9.0 0.7 0.7 7.9 0.4 53.4 44.5 0.4 41.1 53.8 8.5 5.3 0.0 0.5 0.3 39.2 0.4 3.5 0.0 0.5 0.4 0.5 46.8 0.0 0.5 0.0 0.5 6.5 34.0 0.1 55.8 6.4 0.4 56.2 38.4 0.8 0.2 0.1 23.7 0.7 0.4 0.7 0.2 0.0 9.0 18.4 18.8 0.9 3.6 0.0 0.0 0.1 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 1.8 0.0 0.1 0.0 1.3 0.0 0.0 0.1 0.9 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 6.3 0.1 0.4 0.0 0.0 0.0 0.1 0.0 0.4 0.0 58.5 0.2 0.2 0.0 19.4 0.0 0.0 60.5 0.0 0.0 0.1 0.0 0.2 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.1 0.1 0.1 0.1 0.0 0.4 0.5 0.7 0.7 0.5 0.3 0.5 0.4 0.5 0.2 0.4 0.9 0.1 35.3 6.9 0.0 1.1 4.1 14.7 12.5 5.2 0.0 17.9 11.0 0.2 20.0 38.0 23.9 2.1 0.0 0.3 208.5 21.5 23.8 0.1 7.4 0.3 0.5 6.0 0.0 0.0 38.2 0.0 0.9 24.5 2.6 0.0 0.1 0.4 0.0 0.1 0.0 0.0 69.4 12.2 0.0 1.8 0.2 0.6 0.6 0.0 0.0 2.0 0.1 0.0 0.0 0.0 10.6 135.8 0.0 0.0 5.5 130.9 39.5 45.9 0.3 0.0 0.4 2.3 0.0 0.1 30.6 20.9 0.0 1.0 0.0 86.1 26.7 GGT7 "D20S101, dJ18C9.2, GGTL3, GGTL5" ENSG00000131067 "Gamma-glutamyltransferase 7" Q9UJ14 20 34844720-34872856 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glutathione biosynthesis" "Acyltransferase, Hydrolase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 60.9;Inhibitory neurons: 58.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA013204, HPA013339" Approved Approved Nucleoplasm,Vesicles NA NA 1900000 "Cluster 30: Non-specific - Translation" "Cluster 80: Striated muscle - Unknown function" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Vesicles Nucleoplasm "HPA013204: AB_1850347, HPA013339: AB_2668816" "unprognostic (1.32e-3)" "unprognostic (2.33e-1)" "unprognostic (9.31e-2)" "prognostic unfavorable (1.26e-5)" "unprognostic (1.27e-1)" "unprognostic (6.55e-2)" "unprognostic (1.46e-3)" "unprognostic (2.49e-2)" "unprognostic (3.49e-1)" "unprognostic (1.16e-2)" "unprognostic (3.34e-3)" "unprognostic (3.61e-2)" "unprognostic (5.00e-3)" "unprognostic (1.81e-1)" "unprognostic (1.63e-1)" "unprognostic (5.50e-2)" "unprognostic (2.00e-1)" 13.2 13.8 37.0 11.8 35.8 5.5 15.4 43.4 43.8 25.6 53.2 19.1 16.0 19.3 29.1 10.1 21.1 18.2 22.3 38.6 33.3 24.9 16.8 14.4 18.2 34.3 28.9 24.1 27.1 22.9 40.5 13.7 33.6 24.8 14.9 22.7 30.8 22.6 67.5 17.9 20.1 14.9 22.5 15.4 22.1 10.1 32.0 15.8 28.8 13.8 13.6 19.7 18.0 35.4 5.2 7.7 38.5 39.5 29.7 26.4 34.2 21.7 21.9 17.5 26.0 40.6 25.5 0.0 25.1 17.1 17.8 3.6 16.8 9.5 11.5 1.8 29.9 15.9 16.0 21.3 26.5 0.8 24.9 38.5 10.6 19.7 9.1 52.2 1.5 20.3 12.0 2.8 12.2 9.1 4.2 8.1 8.9 9.1 3.8 0.1 26.3 25.9 25.3 7.7 22.4 26.1 11.2 17.6 28.2 14.4 13.5 14.2 0.6 59.8 23.6 5.7 12.6 29.6 4.2 1.9 70.4 1.5 22.4 1.4 2.8 1.5 6.9 2.0 2.0 6.1 5.8 2.6 2.5 5.4 11.5 8.2 0.3 3.0 0.7 1.4 5.1 1.8 37.0 35.8 43.4 43.8 38.6 33.3 34.3 28.9 33.6 22.5 32.0 35.4 2.0 3.2 2.7 23.2 6.4 7.4 18.1 14.8 9.1 40.2 9.6 5.8 1.9 32.9 11.1 18.4 12.5 24.2 2.2 14.2 0.0 16.1 3.2 3.3 7.6 2.1 10.8 1.7 60.9 5.6 12.3 14.0 23.4 4.5 2.5 9.0 1.4 12.1 4.5 40.4 58.0 15.2 38.7 3.2 4.4 1.8 12.5 3.2 10.6 17.8 2.8 9.7 4.1 31.2 25.5 6.3 17.8 7.9 1.9 9.3 11.9 6.1 7.2 19.3 6.6 16.0 9.4 13.9 15.5 5.7 4.3 16.8 7.2 17.0 17.9 13.9 GK "GK1, GKD" ENSG00000198814 "Glycerol kinase" P32189 X 30653359-30731462 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Glycerol metabolism" "Kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 90.7;kidney: 107.7;liver: 79.2" "Cell type enhanced" "Detected in many" "Langerhans cells: 139.2;Macrophages: 133.4;Proximal enterocytes: 144.2;Proximal tubular cells: 161.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 8 "neutrophil: 178.4" "Lineage enriched" "Detected in all" 8 "granulocytes: 178.4" "Cell line enhanced" "Detected in many" "BJ hTERT+: 37.4;Hep G2: 46.4" "Low region specificity" "Detected in all" HPA060687 Supported NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 41: Macrophages - Immune response" "HPA060687: AB_2684343" "unprognostic (8.78e-3)" "unprognostic (8.41e-3)" "unprognostic (1.28e-2)" "unprognostic (3.77e-2)" "unprognostic (3.15e-1)" "unprognostic (4.15e-3)" "unprognostic (5.52e-2)" "unprognostic (1.42e-2)" "unprognostic (3.85e-1)" "unprognostic (8.56e-3)" "unprognostic (1.30e-2)" "unprognostic (1.58e-2)" "prognostic favorable (3.24e-9)" "unprognostic (1.59e-1)" "unprognostic (9.35e-2)" "unprognostic (4.57e-3)" "unprognostic (4.11e-3)" 8.8 9.8 3.1 51.5 2.8 6.6 4.8 3.7 17.2 4.8 8.4 13.0 86.6 3.6 12.3 9.6 7.7 23.8 4.8 2.3 4.1 107.7 79.2 19.7 10.6 7.2 4.2 2.6 4.5 14.0 5.4 8.2 6.8 3.6 10.9 10.3 11.2 2.2 2.6 6.3 90.7 4.4 3.6 10.1 6.2 2.9 14.5 5.4 6.6 3.1 14.5 30.2 2.7 8.0 4.5 3.5 4.5 7.7 2.7 10.4 1.8 10.6 37.4 7.6 8.6 5.8 4.1 12.6 1.7 4.1 6.9 0.3 8.5 3.5 10.1 8.2 9.6 7.5 6.6 46.4 17.2 14.2 15.4 6.3 4.9 24.2 22.3 1.9 6.0 9.6 4.0 17.3 2.1 6.2 11.0 14.6 7.5 4.9 4.0 15.0 7.1 13.1 5.7 14.8 4.8 6.1 9.4 9.4 21.5 4.5 10.6 10.1 2.3 5.5 2.3 0.3 4.9 9.1 10.7 12.5 9.5 9.1 5.6 5.0 22.8 7.9 1.7 7.2 1.3 3.1 3.1 2.2 14.2 5.6 1.8 1.9 178.4 4.8 9.1 4.2 11.5 6.2 3.1 2.8 3.7 17.2 2.3 4.1 7.2 4.2 6.8 3.6 14.5 8.0 2.0 16.0 27.4 19.6 15.8 6.9 12.3 12.6 4.6 3.2 9.4 3.9 4.3 12.8 22.5 7.3 16.7 1.2 5.6 54.7 35.2 21.9 61.5 15.1 2.7 3.8 12.1 6.3 41.5 11.1 1.1 12.4 20.9 1.7 14.5 6.9 3.6 38.1 34.8 5.0 37.2 14.7 0.0 26.6 139.2 29.9 1.2 133.4 14.2 10.3 42.6 29.1 3.1 28.6 19.6 10.6 39.9 2.2 12.4 17.0 144.2 161.1 47.7 17.7 0.0 9.2 7.0 15.3 1.7 14.7 16.9 0.8 15.7 3.7 11.0 26.8 GK2 "GKP2, GKTA" ENSG00000196475 "Glycerol kinase 2" Q14410 4 79406361-79408228 "Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Glycerol metabolism" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in single" 306 "testis: 89.5" "Group enriched" "Detected in some" 92 "Early spermatids: 589.0;Late spermatids: 163.3;Spermatocytes: 194.7" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 40 "SCLC-21H: 3.9" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA060687 Uncertain NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA060687: AB_2684343" "unprognostic (1.31e-1)" 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 89.5 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.2 0.2 0.2 0.2 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 589.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 163.3 3.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 194.7 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GK3P "GKP3, GKTB" ENSG00000229894 "Glycerol kinase 3 pseudogene" Q14409 4 165277812-165279679 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycerol metabolism" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "testis: 13.4" "Cell type enhanced" "Detected in some" "Astrocytes: 1.0;Distal tubular cells: 1.9;Excitatory neurons: 1.3;Microglial cells: 1.0;Oligodendrocyte precursor cells: 1.5" "Not detected" "Not detected" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA060687 Uncertain NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 78: Testis - Spermatogenesis" "Cluster 11: Alveolar cells - Smell perception" "HPA060687: AB_2684343" "unprognostic (1.34e-1)" "unprognostic (2.41e-1)" "unprognostic (3.01e-2)" "unprognostic (1.17e-2)" "unprognostic (2.11e-2)" "unprognostic (3.94e-1)" "unprognostic (1.61e-1)" "unprognostic (2.04e-1)" "unprognostic (6.19e-2)" "unprognostic (6.99e-2)" "unprognostic (4.63e-2)" "unprognostic (2.02e-1)" "unprognostic (4.56e-1)" "unprognostic (3.34e-4)" 0.0 0.0 0.1 0.0 0.9 0.4 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 13.4 0.6 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.1 0.9 0.0 1.2 1.8 0.0 0.2 0.0 0.1 0.0 0.6 1.1 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.1 0.1 0.0 0.0 0.0 1.3 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 1.0 0.0 0.0 0.0 1.5 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GK5 MGC40579 ENSG00000175066 "Glycerol kinase 5" Q6ZS86 3 142157527-142225592 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycerol metabolism" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "NK-cells: 127.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA042606, HPA057998" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 51: Non-specific - Unknown function" "Cluster 6: T47d - Mammary gland" "Cluster 63: NK-cells & T-cells - Immune response" "Nucleoplasm, Cytosol" "HPA042606: AB_10795509, HPA057998: AB_2683573" "unprognostic (7.79e-2)" "unprognostic (5.15e-2)" "unprognostic (2.02e-2)" "unprognostic (1.33e-1)" "unprognostic (3.07e-2)" "unprognostic (3.60e-2)" "unprognostic (9.89e-3)" "unprognostic (3.13e-1)" "unprognostic (2.77e-2)" "unprognostic (1.76e-2)" "unprognostic (7.76e-2)" "unprognostic (2.03e-1)" "unprognostic (1.12e-2)" "unprognostic (2.10e-3)" "unprognostic (4.49e-2)" "unprognostic (1.32e-1)" "unprognostic (5.59e-3)" 4.6 7.0 2.3 3.8 2.4 7.8 6.8 4.8 2.7 5.0 7.0 6.8 9.4 5.4 9.0 4.3 6.0 3.2 2.4 2.3 2.4 3.6 2.1 3.8 2.2 4.4 3.1 8.6 4.0 3.1 5.8 1.7 4.0 8.4 7.3 4.7 11.0 4.0 2.5 5.9 8.0 3.3 2.9 2.2 5.2 3.2 3.0 2.1 4.6 1.5 2.4 4.2 4.4 4.6 11.2 2.7 3.9 2.6 8.0 15.2 6.7 3.6 2.5 3.9 2.5 4.2 6.0 7.9 3.2 3.5 4.3 4.6 4.5 3.5 5.2 2.9 4.3 5.2 7.1 3.1 4.3 6.1 6.7 6.2 3.0 2.6 3.4 2.5 2.3 9.1 4.6 4.7 7.2 7.2 5.3 5.0 2.5 7.5 3.1 4.9 4.2 2.9 4.1 6.8 3.8 2.8 10.1 10.5 3.3 2.3 14.8 4.0 2.5 3.1 2.6 6.9 4.1 4.9 5.1 8.1 5.6 3.8 5.3 2.0 0.4 0.3 1.5 0.3 0.7 0.2 0.5 0.5 0.3 0.4 0.3 0.6 1.1 1.5 2.6 0.4 0.2 0.2 2.3 2.4 4.8 2.7 2.3 2.4 4.4 3.1 4.0 2.9 3.0 4.6 13.7 38.5 30.7 31.6 6.8 4.0 12.3 3.7 15.9 30.6 26.6 13.6 10.5 17.2 17.3 27.6 29.2 13.1 80.5 37.4 7.9 14.9 2.8 32.7 22.5 9.7 27.9 8.8 37.6 20.4 7.3 15.2 25.0 39.2 8.8 23.2 5.0 11.8 5.6 15.2 44.1 42.0 0.0 10.0 3.9 5.2 33.8 20.2 3.6 15.9 9.3 10.2 127.7 27.6 75.6 19.3 31.6 46.6 34.6 21.5 69.5 6.1 14.1 33.0 26.3 16.0 9.0 4.0 5.9 19.4 4.0 6.8 21.0 21.1 34.5 17.3 GLUL GLNS ENSG00000135821 "Glutamate-ammonia ligase" P15104 1 182378098-182392206 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Angiogenesis "Ligase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 1443.6" "Group enriched" "Detected in all" 4 "Late spermatids: 8544.2;Muller glia cells: 6247.0" "Cancer enhanced" "Detected in all" "liver cancer: 365.1" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 656.8" "Lineage enriched" "Detected in all" 4 "granulocytes: 656.8" "Cell line enhanced" "Detected in many" "ASC diff: 1150.8;ASC TERT1: 807.6;HSkMC: 702.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007316, HPA007571, CAB008636" Approved Supported "Plasma membrane,Mitochondria,Cytosol" NA NA 150000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 80: Striated muscle - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 25: Spermatids - Spermatogenesis" "Mitochondria, Cytosol" "Plasma membrane" "CAB008636: AB_1616669, HPA007316: AB_888438, HPA007571: AB_1078980" "prognostic favorable (4.81e-4)" "unprognostic (1.52e-3)" "unprognostic (3.89e-1)" "unprognostic (3.32e-1)" "unprognostic (1.25e-1)" "unprognostic (9.52e-2)" "unprognostic (7.58e-2)" "unprognostic (1.03e-1)" "unprognostic (1.26e-1)" "unprognostic (8.92e-2)" "unprognostic (1.32e-1)" "unprognostic (1.17e-1)" "unprognostic (1.38e-2)" "unprognostic (4.17e-2)" "unprognostic (2.06e-1)" "unprognostic (5.55e-2)" "unprognostic (4.53e-3)" 753.5 76.0 694.3 156.9 746.5 232.9 573.5 717.5 1237.1 161.4 583.2 157.8 24.4 116.7 115.7 218.7 224.3 105.4 129.7 676.6 764.7 65.3 280.7 221.7 75.2 891.0 783.7 303.0 204.7 32.3 70.5 176.6 767.0 103.4 92.5 891.1 233.5 96.0 1443.6 231.4 148.2 124.1 725.0 216.4 648.2 87.1 811.4 97.0 257.4 472.0 103.2 185.5 292.0 810.4 26.4 10.8 117.2 0.2 1150.8 807.6 86.0 44.1 141.7 25.9 23.4 64.1 26.7 22.4 46.3 85.5 23.8 59.3 51.8 309.4 21.5 61.2 143.3 296.5 47.6 124.8 61.1 132.6 227.2 702.1 363.3 32.9 384.6 39.1 52.8 71.7 254.3 13.3 92.6 15.0 208.2 126.5 87.3 36.8 55.0 74.3 31.3 38.6 45.8 114.0 79.7 52.5 12.4 157.3 17.4 93.3 153.1 165.9 39.7 0.9 1.9 0.8 10.1 4.8 3.4 0.4 22.3 73.9 5.0 396.5 153.4 409.4 42.3 145.8 17.6 11.5 29.9 35.5 80.0 17.8 15.3 25.3 656.8 27.2 130.5 43.7 13.0 172.0 694.3 746.5 717.5 1237.1 676.6 764.7 891.0 783.7 767.0 725.0 811.4 810.4 127.8 125.0 173.8 599.4 37.6 134.7 533.8 1190.7 260.0 105.6 166.6 99.1 216.2 171.6 855.3 82.8 52.1 161.7 113.4 118.3 74.3 124.2 1491.3 140.2 150.0 191.5 325.9 319.7 3.4 116.6 65.9 404.4 388.4 124.6 786.3 88.0 152.8 597.1 798.0 43.7 22.0 256.7 451.6 907.2 614.1 8544.2 487.4 687.4 136.9 74.9 112.7 6247.0 42.2 38.2 330.0 108.1 105.3 375.0 38.7 421.0 10.3 46.6 569.9 176.0 92.1 481.5 218.5 48.2 63.6 186.5 128.3 235.3 108.6 53.3 173.3 1420.5 GLYAT "ACGNAT, GAT" ENSG00000149124 Glycine-N-acyltransferase Q6IB77 11 58640426-58731974 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Detoxification "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 14 "kidney: 571.8;liver: 698.0" "Group enriched" "Detected in some" 6 "Hepatocytes: 346.7;Proximal tubular cells: 1261.0" "Group enriched" "Detected in some" 158 "liver cancer: 21.7;renal cancer: 25.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "U-937: 1.4" "Not detected" "Not detected" "HPA040251, HPA044094" Enhanced NA NA 21000 "Cluster 81: Kidney & Liver - Metabolism" "Cluster 32: U-937 - Innate immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA040251: AB_2676902, HPA044094: AB_2678807" "unprognostic (2.15e-2)" "unprognostic (9.38e-4)" "unprognostic (4.60e-2)" "unprognostic (1.65e-3)" "unprognostic (1.83e-1)" "unprognostic (1.60e-1)" "prognostic favorable (1.31e-6)" "unprognostic (2.69e-1)" 47.0 0.1 0.0 0.1 0.1 0.1 8.5 0.1 0.2 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.0 0.4 0.2 0.1 0.0 571.8 698.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.1 0.1 1.2 0.0 0.1 0.2 0.1 0.0 0.0 0.1 0.3 0.5 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.2 0.0 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.3 0.3 0.1 0.0 1.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.2 0.1 0.0 0.1 0.0 0.2 0.0 0.0 0.1 0.3 0.0 0.0 0.0 5.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 11.5 0.0 31.3 0.0 0.1 0.0 0.0 123.3 0.0 6.0 0.0 0.0 0.6 0.0 8.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 10.8 346.7 0.0 0.0 0.2 0.0 0.0 10.7 0.0 8.2 0.0 6.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1261.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 3.8 0.0 0.0 0.0 GLYATL1 "FLJ34646, MGC15397" ENSG00000166840 "Glycine-N-acyltransferase like 1" Q969I3 11 58905398-59043527 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 4 "liver: 576.3" "Group enriched" "Detected in some" 4 "Hepatocytes: 234.3;Proximal tubular cells: 797.1" "Group enriched" "Detected in some" 8 "liver cancer: 14.1;prostate cancer: 13.3;renal cancer: 10.1" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CACO-2: 2.0;Daudi: 4.9;RPTEC TERT1: 1.5;U-2197: 1.2" HPA039501 Supported Uncertain "Golgi apparatus,Cytosol" NA NA "Cluster 85: Liver - Metabolism" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Golgi apparatus" Cytosol "HPA039501: AB_2676545" "unprognostic (9.46e-3)" "unprognostic (5.33e-2)" "unprognostic (3.90e-5)" "unprognostic (3.93e-3)" "unprognostic (3.54e-3)" "unprognostic (2.17e-1)" "prognostic favorable (3.69e-4)" "unprognostic (3.62e-1)" "unprognostic (2.51e-1)" "unprognostic (1.05e-1)" "unprognostic (2.08e-1)" "unprognostic (2.92e-1)" "prognostic favorable (3.03e-5)" "unprognostic (1.50e-1)" "unprognostic (1.01e-1)" "unprognostic (1.86e-2)" "unprognostic (4.55e-2)" 0.0 0.0 0.1 0.0 0.1 0.0 1.3 0.3 0.4 0.1 0.4 0.3 1.6 0.1 0.7 0.1 1.3 0.9 0.0 0.1 0.3 141.4 576.3 0.0 0.1 0.9 0.2 0.0 1.7 2.6 0.0 0.0 1.1 11.1 0.3 0.2 1.9 0.0 0.0 0.6 0.2 0.0 0.3 0.1 2.7 0.1 0.3 2.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.2 0.6 0.0 0.2 0.1 0.5 0.4 2.0 0.0 4.9 0.0 0.3 0.4 0.0 0.0 0.0 0.8 0.0 0.2 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.2 1.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 1.5 0.0 0.1 0.0 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.6 0.0 1.2 0.8 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.3 0.4 0.1 0.3 0.9 0.2 1.1 0.3 0.3 0.3 0.0 0.0 0.0 0.0 3.5 0.0 0.1 0.0 0.0 0.0 1.8 0.0 0.3 12.8 0.0 14.7 0.0 0.0 0.0 0.1 107.6 0.1 0.0 2.5 0.1 0.5 0.0 8.0 0.7 0.6 0.0 0.1 0.0 0.1 0.0 0.1 5.0 234.3 0.0 0.0 0.8 0.1 0.0 8.1 0.0 0.0 0.0 3.1 1.8 0.0 0.0 0.0 0.0 0.5 0.2 0.3 0.0 0.0 0.0 1.3 0.0 797.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.3 0.0 1.9 0.1 0.9 0.2 GLYATL1B GLYATL1P3 ENSG00000255151 "Glycine-N-acyltransferase like 1B" A0A0U1RQE8 11 59086307-59094786 "Enzymes, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Group enriched" "Detected in some" 7 "breast: 7.3;lymphoid tissue: 2.8" "Cell type enriched" "Detected in single" 57 "Proximal tubular cells: 5.8" "Cancer enhanced" "Detected in single" "prostate cancer: 0.7" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "naive B-cell: 1.5" "Lineage enriched" "Detected in single" 15 "B-cells: 1.5" "Cell line enhanced" "Detected in some" "Daudi: 1.8;T-47d: 1.2;U-266/70: 1.8" HPA039501 Uncertain Uncertain "Golgi apparatus,Cytosol" NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 16: Immune cells - Immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Golgi apparatus" Cytosol "HPA039501: AB_2676545" "unprognostic (1.39e-1)" "unprognostic (3.46e-1)" "unprognostic (1.44e-1)" "unprognostic (1.25e-1)" "unprognostic (5.20e-2)" "unprognostic (2.62e-1)" "unprognostic (2.11e-1)" "unprognostic (3.21e-4)" "unprognostic (3.45e-1)" 0.0 0.0 0.0 0.8 0.0 0.0 7.3 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.2 0.0 0.0 0.2 0.1 0.0 0.0 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.4 0.8 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.1 0.9 0.0 1.8 0.6 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GLYATL2 "BXMAS2-10, MGC24009" ENSG00000156689 "Glycine-N-acyltransferase like 2" Q8WU03 11 58834065-58904215 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "breast: 12.0;cervix: 19.9;salivary gland: 33.4" "Cell type enhanced" "Detected in some" "Breast glandular cells: 14.8;Oligodendrocyte precursor cells: 3.0;Prostatic glandular cells: 3.6;Sertoli cells: 6.6" "Group enriched" "Detected in many" 4 "breast cancer: 16.7;endometrial cancer: 15.7" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BJ hTERT+: 5.3;BJ hTERT+ SV40 Large T+ RasG12V: 3.7;HAP1: 6.0;SK-BR-3: 14.1;U-2197: 6.6" "Low region specificity" "Detected in many" "HPA060292, HPA065454" Uncertain Approved Mitochondria NA NA "Cluster 24: Salivary gland - Salivary secretion" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 35: Glandular cells - Unknown function" Mitochondria "HPA060292: AB_2684245, HPA065454: " "unprognostic (1.02e-2)" "unprognostic (3.79e-3)" "unprognostic (8.11e-4)" "prognostic favorable (9.05e-7)" "unprognostic (1.05e-1)" "unprognostic (8.41e-2)" "unprognostic (2.66e-2)" "unprognostic (9.98e-3)" "unprognostic (1.27e-1)" "unprognostic (9.18e-3)" "unprognostic (1.64e-1)" "unprognostic (1.59e-1)" "unprognostic (7.42e-5)" "unprognostic (7.79e-3)" "unprognostic (8.28e-2)" "unprognostic (9.11e-3)" "unprognostic (2.31e-2)" 0.2 0.1 0.2 0.1 0.3 0.1 12.0 0.2 0.5 19.9 0.0 0.1 0.3 0.4 0.3 0.9 0.1 7.5 0.3 0.2 0.4 0.9 0.1 0.0 0.3 0.7 0.2 0.0 0.1 0.0 0.1 0.0 0.6 0.9 0.2 0.3 33.4 0.1 0.0 1.4 0.1 0.3 0.7 0.3 0.1 0.0 0.2 0.1 0.1 0.5 0.4 0.1 0.3 1.1 0.0 0.0 0.4 0.0 0.7 2.6 0.0 1.7 5.3 2.3 3.7 0.0 0.0 0.1 0.0 1.4 1.0 0.4 6.0 0.0 1.9 0.0 1.1 0.0 0.0 0.0 0.2 0.0 0.2 0.5 0.0 0.5 0.2 2.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.1 0.1 14.1 0.0 0.0 0.0 0.0 0.0 1.8 0.1 6.6 2.0 0.0 0.0 0.1 0.0 0.0 0.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.2 0.3 0.2 0.5 0.2 0.4 0.7 0.2 0.6 0.7 0.2 1.1 0.2 0.0 0.0 0.0 0.0 1.0 2.3 1.4 0.0 0.5 14.8 2.2 0.1 0.0 1.5 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.5 0.4 1.1 0.0 0.0 1.5 1.4 0.0 0.5 0.0 1.2 0.0 0.4 0.0 0.0 0.1 0.0 1.5 0.0 0.0 0.0 0.4 0.0 0.0 0.3 1.8 0.0 0.0 0.0 0.0 3.0 0.4 0.1 0.0 0.0 0.0 3.6 0.0 0.2 0.1 0.1 6.6 0.2 0.6 0.0 0.1 0.0 2.0 0.0 0.0 0.0 0.0 1.9 GLYATL3 "bA28H17.2, C6orf140" ENSG00000203972 "Glycine-N-acyltransferase like 3" Q5SZD4 6 49499923-49528078 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in single" "liver: 1.2" "Not detected" "Not detected" "Cancer enhanced" "Detected in single" "endometrial cancer: 0.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 67 "T-47d: 13.7" "Not detected" "Not detected" "Not detected" "Not detected" HPA044044 Uncertain NA NA "Cluster 85: Liver - Metabolism" "Cluster 6: T47d - Mammary gland" "HPA044044: AB_10960855" "unprognostic (3.57e-1)" "unprognostic (6.85e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.7 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GLYCTK "HBEBP2, HBEBP4" ENSG00000168237 "Glycerate kinase" Q8IVS8 3 52287089-52295257 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 11 "liver: 275.1" "Cell type enhanced" "Detected in many" "Hepatocytes: 183.0;Proximal enterocytes: 105.2;Proximal tubular cells: 83.0" "Cancer enriched" "Detected in all" 6 "liver cancer: 52.7" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006913 Approved Approved "Golgi apparatus,Cytosol,Rods & Rings" NA NA "Cluster 35: T-regs - Unknown function" "Cluster 62: Liver - Hemostasis" "Cluster 21: OE19 - Mitochondria" "Cluster 2: Hepatocytes - Metabolism" Cytosol "Golgi apparatus, Rods & Rings" "HPA006913: AB_1078993" "unprognostic (1.51e-2)" "unprognostic (2.55e-1)" "unprognostic (1.25e-1)" "unprognostic (3.46e-2)" "unprognostic (1.18e-1)" "prognostic favorable (1.64e-4)" "unprognostic (2.72e-2)" "unprognostic (2.84e-2)" "unprognostic (7.73e-3)" "unprognostic (1.82e-1)" "unprognostic (3.36e-3)" "unprognostic (2.15e-1)" "unprognostic (3.30e-2)" "unprognostic (3.42e-1)" "unprognostic (3.77e-1)" "unprognostic (3.82e-2)" "unprognostic (9.00e-3)" 14.8 8.3 1.0 4.5 0.9 6.7 9.3 0.5 1.5 2.9 0.9 11.4 22.4 3.2 0.6 3.8 2.7 2.2 4.4 0.9 1.2 24.9 275.1 4.2 4.6 1.4 0.9 2.4 5.9 2.5 2.9 2.2 1.2 3.7 3.6 0.6 3.1 1.0 3.6 1.9 21.7 1.6 0.4 8.9 8.5 2.3 1.2 2.3 4.1 1.0 3.2 3.3 2.5 1.2 2.9 5.8 3.4 1.2 15.7 2.4 1.8 2.4 2.6 4.6 3.9 12.1 2.4 6.7 1.6 2.7 3.7 1.6 1.7 7.8 0.8 2.0 1.8 9.3 7.5 16.2 1.7 2.8 5.0 2.4 3.5 7.6 3.2 2.1 10.2 5.2 2.4 4.5 3.6 1.9 5.9 2.7 1.5 14.2 4.2 1.9 2.5 11.1 5.8 3.9 1.9 1.9 2.6 1.4 3.0 1.0 3.2 1.7 3.8 3.5 4.1 2.4 6.1 5.1 3.9 5.4 2.7 4.9 2.2 2.2 5.2 6.6 5.6 2.8 2.6 4.4 4.2 4.9 5.6 2.6 3.3 4.3 4.4 3.6 3.5 3.4 6.6 3.7 1.0 0.9 0.5 1.5 0.9 1.2 1.4 0.9 1.2 0.4 1.2 1.2 5.4 6.4 3.2 0.7 8.2 0.4 3.2 4.1 1.8 1.6 2.1 1.4 1.6 18.6 3.0 9.2 0.0 7.9 9.2 18.4 19.6 5.4 0.3 4.4 2.7 8.3 23.4 26.5 0.6 6.2 5.3 2.9 27.0 8.6 1.3 3.4 14.6 183.0 13.2 0.0 0.4 15.8 2.0 16.6 2.4 0.0 1.2 9.1 3.6 1.0 7.7 1.2 9.2 0.5 0.7 4.0 40.6 0.0 13.5 2.8 105.2 83.0 2.4 1.5 0.0 2.7 2.7 1.8 8.3 2.1 1.3 11.1 9.3 7.7 24.9 4.3 GMPPB KIAA1851 ENSG00000173540 "GDP-mannose pyrophosphorylase B" Q9Y5P6 3 49716844-49723973 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Nucleotidyltransferase, Transferase" "Congenital muscular dystrophy, Disease variant, Dystroglycanopathy, Limb-girdle muscular dystrophy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Plasma cells: 130.2;Syncytiotrophoblasts: 79.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA014657 Uncertain NA NA 38000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 55: Plasma cells - Humoral immune response" "HPA014657: AB_1849852" "unprognostic (3.48e-2)" "unprognostic (9.84e-2)" "unprognostic (2.77e-2)" "prognostic favorable (6.19e-6)" "unprognostic (1.01e-2)" "unprognostic (5.11e-3)" "unprognostic (1.54e-2)" "unprognostic (4.01e-3)" "unprognostic (1.04e-1)" "unprognostic (1.99e-2)" "unprognostic (5.01e-3)" "unprognostic (5.73e-2)" "prognostic favorable (3.17e-4)" "unprognostic (1.60e-1)" "unprognostic (1.79e-1)" "unprognostic (1.67e-1)" "unprognostic (1.22e-1)" 14.5 30.1 6.1 16.1 6.0 11.8 15.3 5.7 6.6 20.8 9.2 23.1 14.5 18.6 14.5 26.3 19.5 9.5 18.2 6.0 6.3 17.5 44.2 21.4 13.0 6.7 6.5 14.0 57.4 10.1 39.4 7.5 6.1 27.9 12.2 4.1 35.4 14.7 13.4 14.9 21.8 9.4 6.1 27.9 26.2 9.6 6.8 9.3 26.3 5.7 13.0 15.9 16.8 5.9 31.8 27.0 21.0 12.3 15.6 10.8 21.7 36.1 17.1 29.0 26.1 18.7 21.5 17.6 15.8 18.1 22.2 16.7 18.6 29.0 10.6 17.2 14.5 13.5 27.2 21.5 31.1 19.0 19.6 8.2 15.1 40.0 34.8 11.3 24.8 20.2 10.4 32.0 16.3 20.3 27.3 11.7 12.2 22.5 34.3 9.2 12.5 30.4 16.3 24.0 13.8 16.0 15.7 36.5 12.5 10.6 20.6 13.9 21.9 25.7 25.0 33.4 38.8 33.7 11.1 13.6 25.4 14.7 28.6 22.1 15.6 6.7 18.3 21.3 18.6 22.7 15.9 19.3 14.7 22.5 11.8 14.6 4.0 11.3 21.8 61.8 12.0 14.8 6.1 6.0 5.7 6.6 6.0 6.3 6.7 6.5 6.1 6.1 6.8 5.9 7.3 9.6 17.2 1.6 35.4 0.8 22.8 0.7 2.8 3.7 34.1 14.1 4.5 15.7 3.8 18.4 2.1 28.5 28.5 43.6 29.4 39.8 10.0 18.3 14.3 10.7 16.7 9.9 0.8 50.6 67.2 15.5 34.7 17.8 0.0 11.2 9.3 28.4 39.0 6.7 0.8 55.9 0.0 10.7 1.7 10.0 15.5 13.7 1.8 1.0 40.9 5.8 19.6 1.0 0.4 31.9 27.1 7.5 130.2 40.9 29.2 25.7 14.4 6.2 0.0 5.3 12.2 22.9 12.6 14.7 1.7 79.5 14.7 13.1 32.8 37.1 GNE "IBM2, Uae1" ENSG00000159921 "Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase" Q9Y223 9 36214441-36277042 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Allosteric enzyme, Hydrolase, Kinase, Multifunctional enzyme, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 4 "intestine: 48.4;liver: 90.5;salivary gland: 55.3" "Cell type enhanced" "Detected in all" "Distal enterocytes: 59.3;Hepatocytes: 119.3;Intestinal goblet cells: 88.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "RPTEC TERT1: 107.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007045, HPA027258" Approved Supported Cytosol NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 85: Liver - Metabolism" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 27: Mucus-secreting cells - Mucin production" Cytosol "HPA007045: AB_1079003, HPA027258: AB_1849873" "unprognostic (7.54e-2)" "unprognostic (1.61e-2)" "unprognostic (1.07e-3)" "unprognostic (7.28e-2)" "unprognostic (7.00e-2)" "unprognostic (1.85e-2)" "unprognostic (2.78e-3)" "unprognostic (5.39e-2)" "unprognostic (1.73e-1)" "unprognostic (1.70e-2)" "unprognostic (2.88e-3)" "unprognostic (4.20e-2)" "prognostic favorable (9.28e-11)" "unprognostic (2.90e-1)" "unprognostic (8.28e-2)" "unprognostic (2.95e-1)" "unprognostic (1.72e-2)" 11.9 9.0 5.5 8.7 7.4 15.5 15.8 8.9 6.5 11.3 7.9 34.0 4.3 10.3 3.5 11.6 9.1 7.4 7.7 5.5 7.3 10.0 90.5 6.8 7.3 7.7 7.3 14.8 10.2 6.1 4.8 14.2 8.9 15.3 48.4 8.0 55.3 7.2 7.9 3.8 7.6 11.7 6.6 6.2 4.6 4.8 7.1 6.2 6.9 15.3 9.5 14.2 7.5 10.5 9.9 44.4 20.1 17.1 22.5 22.4 29.9 13.5 17.9 19.5 25.1 10.5 32.6 13.5 14.2 24.2 50.5 3.9 15.3 4.6 21.8 25.1 1.4 11.0 26.0 15.2 15.4 0.2 31.2 14.4 4.6 32.0 30.6 14.3 8.4 20.7 14.4 27.3 19.3 1.8 19.1 6.3 11.8 6.7 23.7 15.5 16.3 3.8 107.7 19.4 16.7 15.2 13.7 5.3 12.6 7.1 4.8 12.0 12.2 12.7 12.9 15.5 12.2 11.7 26.0 7.0 17.0 9.8 18.2 0.2 0.5 0.2 0.7 0.6 0.5 0.6 0.9 0.8 0.4 0.9 1.0 1.2 0.3 0.7 0.8 0.6 0.4 0.6 5.5 7.4 8.9 6.5 5.5 7.3 7.7 7.3 8.9 6.6 7.1 10.5 9.7 9.6 10.0 9.4 7.1 1.9 3.1 6.7 1.8 8.4 8.2 7.5 6.7 10.0 16.9 9.2 6.2 8.6 4.3 59.3 1.9 10.4 3.4 7.2 12.1 6.3 11.5 7.8 12.8 6.0 9.5 8.3 2.6 10.6 10.1 9.1 7.1 119.3 2.9 11.8 15.6 88.1 16.2 7.8 4.4 2.4 10.8 5.4 1.8 5.6 6.1 1.9 2.1 32.2 28.2 5.3 20.3 6.4 7.9 6.9 2.9 2.2 18.8 6.9 13.1 10.0 6.3 1.8 2.7 1.2 1.6 19.8 5.7 2.3 26.8 13.4 GNMT ENSG00000124713 "Glycine N-methyltransferase" Q14749 6 42960754-42963880 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Methyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 9 "liver: 296.5;pancreas: 600.1" "Cell type enriched" "Detected in many" 10 "Hepatocytes: 842.9" "Group enriched" "Detected in many" 20 "liver cancer: 69.6;prostate cancer: 49.8" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "Hep G2: 8.5;SCLC-21H: 9.5;T-47d: 6.1" "Region enriched" "Detected in some" 4 "cerebellum: 15.7" "Low region specificity" "Detected in many" HPA027501 Enhanced Approved Cytosol NA NA 390000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 25: Pancreas - Digestion" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 2: Hepatocytes - Metabolism" Cytosol "HPA027501: AB_1849879" "unprognostic (1.53e-2)" "unprognostic (8.02e-4)" "unprognostic (3.11e-2)" "unprognostic (4.24e-3)" "unprognostic (3.91e-2)" "unprognostic (6.40e-4)" "prognostic favorable (1.86e-4)" "unprognostic (4.08e-6)" "unprognostic (1.01e-1)" "unprognostic (2.67e-2)" "unprognostic (1.63e-3)" "unprognostic (2.52e-1)" "unprognostic (3.50e-3)" "unprognostic (1.03e-1)" "unprognostic (1.99e-1)" "unprognostic (2.49e-2)" "unprognostic (4.92e-2)" 0.9 0.9 2.3 1.3 2.5 3.8 7.1 2.8 2.4 0.8 2.0 0.7 0.2 0.8 2.2 0.6 1.3 0.5 4.7 2.2 2.2 0.9 296.5 2.0 1.0 1.1 1.0 1.9 600.1 0.2 8.4 0.4 1.1 20.3 0.3 2.2 9.8 1.2 1.8 0.9 1.6 0.5 0.9 2.9 50.8 0.7 1.9 1.8 1.9 0.4 1.2 0.8 0.7 2.1 0.4 0.3 1.4 3.9 0.4 0.1 0.2 0.3 1.6 0.6 0.9 0.0 0.1 1.3 0.1 0.3 0.7 0.4 0.2 0.2 0.2 1.6 1.2 1.0 0.9 8.5 0.0 0.9 1.8 0.3 0.0 0.3 0.1 0.9 0.0 3.0 1.2 1.5 0.2 1.8 1.6 3.0 0.1 0.4 0.4 1.4 1.3 0.8 0.6 0.2 9.5 1.3 0.1 1.3 0.6 0.4 6.1 2.8 0.3 0.7 0.7 0.4 0.8 1.0 1.0 1.1 0.1 1.6 0.8 0.0 0.1 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.2 0.0 0.1 0.2 0.5 0.0 0.0 0.7 0.0 0.1 2.3 2.5 2.8 2.4 2.2 2.2 1.1 1.0 1.1 0.9 1.9 2.1 0.3 0.0 2.2 5.5 2.8 0.3 5.2 0.7 0.0 1.7 10.2 14.7 5.4 24.3 0.2 1.8 0.0 0.1 1.7 0.0 3.9 0.5 0.2 1.6 0.2 2.2 0.0 77.9 18.4 0.9 0.1 0.3 0.5 0.8 0.0 2.6 24.3 842.9 0.7 1.7 18.2 0.0 6.1 28.9 0.7 0.1 0.9 1.1 0.0 11.2 0.3 0.2 0.0 7.1 4.7 0.6 0.0 2.6 0.5 17.9 0.3 3.4 4.6 0.3 0.0 0.2 0.6 0.6 0.7 0.0 0.1 0.1 3.0 0.0 0.2 1.9 GNPAT "DAP-AT, DAPAT, DHAPAT" ENSG00000116906 "Glyceronephosphate O-acyltransferase" O15228 1 231241207-231277973 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Acyltransferase, Transferase" "Cataract, Disease variant, Dwarfism, Rhizomelic chondrodysplasia punctata" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 119.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 25: Spermatids - Spermatogenesis" "unprognostic (8.87e-2)" "unprognostic (3.28e-2)" "unprognostic (3.36e-2)" "unprognostic (2.56e-2)" "unprognostic (5.25e-3)" "unprognostic (1.91e-1)" "unprognostic (5.07e-2)" "unprognostic (6.72e-2)" "unprognostic (1.14e-1)" "unprognostic (1.10e-1)" "unprognostic (1.48e-2)" "unprognostic (2.68e-1)" "prognostic unfavorable (8.29e-6)" "unprognostic (5.69e-2)" "unprognostic (1.66e-1)" "unprognostic (4.48e-2)" "unprognostic (2.68e-1)" 22.4 26.9 21.6 20.5 24.0 17.3 21.7 23.9 28.2 18.3 25.2 30.0 30.0 20.3 23.7 22.1 27.9 18.2 44.9 22.0 23.5 25.7 30.9 18.7 23.6 24.1 22.5 22.5 29.5 22.6 17.9 19.4 23.3 22.8 24.8 17.0 26.4 20.9 101.9 23.6 28.1 26.4 23.6 18.5 26.9 32.0 23.2 27.5 20.8 84.1 25.8 21.5 17.0 26.1 39.8 43.6 60.4 46.1 48.7 71.4 40.7 32.9 37.1 34.1 39.1 56.1 48.3 57.0 40.4 49.5 35.9 41.9 40.6 44.7 50.0 64.8 37.2 41.2 41.4 81.7 49.4 70.9 31.4 50.1 53.8 35.5 39.6 44.5 81.2 56.0 61.1 53.3 71.7 13.1 63.6 41.0 97.1 112.0 49.5 68.7 81.0 66.9 42.7 29.2 40.0 57.1 55.2 30.7 49.1 23.8 53.7 110.7 42.8 34.5 32.1 50.5 83.3 68.2 93.6 65.1 49.8 58.8 65.3 34.1 36.4 37.3 23.7 37.1 27.2 35.1 30.6 31.3 36.4 37.7 26.4 24.4 14.3 26.9 50.3 17.2 37.9 29.8 21.6 24.0 23.9 28.2 22.0 23.5 24.1 22.5 23.3 23.6 23.2 26.1 17.7 25.6 20.8 19.9 32.3 13.5 19.5 23.1 16.5 23.3 14.9 12.6 55.8 30.0 21.2 27.6 39.6 25.3 20.1 16.4 17.6 41.5 70.3 21.5 19.4 21.4 28.2 13.2 18.9 43.4 19.2 19.5 21.4 14.1 11.4 30.1 19.2 26.9 27.4 11.8 18.6 21.0 22.4 24.8 18.3 119.2 25.4 21.8 12.4 15.9 38.7 22.7 26.8 17.1 29.2 40.2 30.3 26.7 30.1 24.9 41.7 28.0 30.8 24.2 19.7 16.5 22.4 50.9 31.5 18.8 13.9 12.4 24.5 19.7 30.1 19.0 GNPNAT1 "FLJ10607, Gpnat1" ENSG00000100522 "Glucosamine-phosphate N-acetyltransferase 1" Q96EK6 14 52775193-52791668 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 77.1" "Cell type enhanced" "Detected in all" "Hepatocytes: 89.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044647 Approved NA NA 72000 "Cluster 27: Non-specific - Gene expression" "Cluster 85: Liver - Metabolism" "Cluster 21: OE19 - Mitochondria" "Cluster 55: Plasma cells - Humoral immune response" "HPA044647: AB_10795986" "unprognostic (4.55e-3)" "unprognostic (1.19e-2)" "unprognostic (4.47e-3)" "unprognostic (5.18e-3)" "unprognostic (4.23e-1)" "unprognostic (1.52e-2)" "unprognostic (1.21e-1)" "unprognostic (3.19e-3)" "unprognostic (1.03e-1)" "unprognostic (6.81e-2)" "prognostic unfavorable (8.52e-5)" "unprognostic (5.82e-2)" "unprognostic (3.22e-3)" "unprognostic (2.16e-2)" "unprognostic (1.68e-1)" "unprognostic (1.31e-1)" "unprognostic (4.05e-2)" 21.5 7.3 4.8 11.1 5.5 3.9 16.8 6.9 6.1 14.6 5.0 18.4 15.0 9.2 9.5 8.5 8.4 11.4 5.4 5.9 5.8 13.6 77.1 6.0 7.3 4.9 4.7 9.3 25.4 8.0 5.8 10.5 5.4 15.5 22.0 5.6 19.3 7.0 11.2 6.7 14.1 10.7 4.9 5.5 19.7 15.3 5.1 5.8 8.5 7.3 8.5 13.8 6.1 6.2 99.8 37.6 30.5 34.7 32.0 73.8 49.9 63.6 41.4 53.5 54.8 43.4 59.1 56.3 34.6 64.2 26.2 40.0 59.2 64.0 92.9 32.4 31.1 38.1 36.2 55.1 46.2 42.7 19.5 29.9 53.1 92.9 99.5 27.7 62.1 35.3 36.7 13.4 70.8 85.6 52.0 21.9 31.8 129.1 67.6 34.7 14.4 33.9 51.2 51.3 30.6 42.8 54.1 70.5 46.6 20.8 83.4 14.6 70.1 55.2 56.9 97.6 50.0 14.0 28.4 24.4 26.1 27.4 32.8 6.4 1.7 0.1 5.0 2.1 6.0 4.6 5.2 4.6 4.0 5.1 5.9 4.7 0.6 5.5 5.0 2.4 6.8 3.1 4.8 5.5 6.9 6.1 5.9 5.8 4.9 4.7 5.4 4.9 5.1 6.2 14.1 16.0 12.1 5.2 10.7 19.2 33.7 19.1 10.2 9.6 23.6 16.3 3.6 18.6 18.5 12.9 4.2 23.3 10.6 13.4 33.2 40.3 43.8 16.0 25.5 17.7 5.4 13.3 16.5 37.6 74.8 25.8 32.6 39.5 7.0 16.5 12.1 89.4 15.5 3.3 10.8 61.0 10.2 6.0 9.3 11.8 19.6 8.6 7.2 8.4 5.4 5.3 18.6 9.0 9.0 45.9 14.0 18.0 13.8 42.0 8.0 16.1 13.0 6.4 19.7 18.3 24.7 71.2 7.2 22.3 21.3 12.2 10.6 13.7 30.1 38.1 GNPTAB "GNPTA, KIAA1208, MGC4170" ENSG00000111670 "N-acetylglucosamine-1-phosphate transferase subunits alpha and beta" Q3T906 12 101745499-101830959 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" Transferase "Cancer-related genes, Disease variant, Mucolipidosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "NK-cells: 192.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA014558, HPA042343" Approved Supported "Golgi apparatus" NA NA 160000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 63: NK-cells & T-cells - Immune response" "Golgi apparatus" "HPA014558: AB_2732409, HPA042343: " "unprognostic (6.72e-2)" "unprognostic (1.66e-1)" "unprognostic (8.71e-3)" "prognostic favorable (8.48e-4)" "unprognostic (1.39e-1)" "unprognostic (8.37e-2)" "unprognostic (2.73e-1)" "unprognostic (8.57e-2)" "unprognostic (3.73e-2)" "unprognostic (1.09e-2)" "unprognostic (2.28e-2)" "unprognostic (2.00e-1)" "unprognostic (6.86e-2)" "unprognostic (3.44e-1)" "unprognostic (1.02e-1)" "unprognostic (5.44e-2)" "unprognostic (4.98e-2)" 11.9 7.9 18.8 16.2 22.2 23.9 16.4 14.4 20.0 17.4 2.7 29.6 14.2 11.8 6.2 15.6 8.8 14.8 21.5 22.7 10.8 14.5 9.4 27.0 20.6 8.5 11.1 7.2 11.3 23.0 8.4 14.8 9.7 20.1 30.3 13.0 54.3 13.0 16.4 25.1 16.2 15.9 8.9 19.0 21.3 10.4 12.4 34.1 13.9 25.9 17.8 19.3 12.0 13.3 18.2 17.5 6.4 10.9 52.3 24.8 19.6 25.4 52.3 24.7 32.2 13.5 12.4 38.1 17.9 35.1 20.1 23.2 29.8 32.8 38.4 18.1 15.6 16.3 15.4 19.3 9.7 15.0 31.7 19.3 17.7 23.5 13.8 61.4 44.0 30.0 25.9 11.0 23.4 27.8 45.6 21.0 22.0 22.6 12.5 10.6 32.6 51.2 39.5 46.8 13.6 11.2 42.3 29.7 60.7 23.5 30.6 9.8 43.6 23.1 12.5 19.6 14.4 30.0 32.9 21.5 26.4 21.8 14.6 8.6 3.8 4.4 18.8 3.6 6.2 3.0 4.0 10.3 7.1 4.9 5.1 7.9 1.4 17.0 4.6 6.9 3.3 3.7 18.8 22.2 14.4 20.0 22.7 10.8 8.5 11.1 9.7 8.9 12.4 13.3 25.3 60.9 65.0 35.9 42.1 16.8 32.9 16.2 17.1 23.6 25.2 18.9 43.5 18.6 27.8 22.0 25.0 25.7 107.3 68.3 7.9 10.3 0.6 25.3 23.7 21.1 18.0 19.5 84.5 15.1 15.0 18.9 33.1 61.6 122.8 24.6 10.4 9.7 46.7 8.4 83.8 29.6 24.4 46.7 17.6 3.8 17.1 41.2 42.7 30.0 43.5 26.9 192.6 135.2 19.8 15.7 129.3 12.8 63.9 28.1 17.7 13.8 10.0 37.0 0.0 18.6 14.9 12.4 33.0 26.7 14.3 8.8 63.4 30.6 49.7 46.5 GOT1 AST1 ENSG00000120053 "Glutamic-oxaloacetic transaminase 1" P17174 10 99396870-99430624 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Amino-acid biosynthesis" "Aminotransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 4 "heart muscle: 511.1;liver: 369.5;skeletal muscle: 489.9;tongue: 1011.6" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 449.0;Distal tubular cells: 240.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA064532, HPA072629" Enhanced Supported Nucleoplasm,Cytosol NA Yes 100000000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 30: Epithelial cell lines - Translation" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm Cytosol "HPA064532: AB_2685279, HPA072629: AB_2686540" "unprognostic (6.40e-2)" "prognostic favorable (6.23e-4)" "unprognostic (5.99e-2)" "unprognostic (2.84e-2)" "unprognostic (2.82e-1)" "unprognostic (2.96e-2)" "unprognostic (5.25e-2)" "unprognostic (1.08e-3)" "unprognostic (6.67e-2)" "unprognostic (1.45e-1)" "unprognostic (1.79e-2)" "unprognostic (1.79e-1)" "prognostic favorable (3.72e-13)" "unprognostic (1.93e-2)" "unprognostic (4.23e-1)" "unprognostic (6.85e-2)" "unprognostic (1.00e-1)" 14.7 54.9 67.8 14.7 71.1 8.0 22.7 70.3 119.1 53.1 82.6 50.9 62.0 13.1 25.9 42.7 17.9 49.0 511.1 70.0 77.6 143.1 369.5 15.5 14.1 83.5 55.0 18.1 34.0 142.4 22.5 14.4 83.7 22.7 59.2 106.2 48.6 27.4 489.9 23.9 45.8 21.4 48.4 16.9 58.9 33.6 69.1 17.7 47.7 1011.6 30.3 22.3 21.0 70.1 73.7 40.3 46.0 114.4 35.1 30.7 127.1 58.9 108.7 101.8 109.8 89.9 56.4 71.9 20.4 50.2 89.2 88.6 107.1 78.9 105.8 25.7 46.7 28.1 46.7 114.3 184.9 77.9 44.0 47.3 82.5 86.9 228.4 69.5 49.5 48.6 71.1 106.2 65.4 64.9 42.5 56.5 29.2 118.7 56.1 45.5 44.4 72.8 173.7 37.5 19.6 28.7 44.8 59.3 222.6 66.8 115.7 27.1 23.3 25.4 56.3 28.0 68.7 76.8 99.7 74.3 65.4 40.8 34.1 4.0 8.7 6.8 19.7 25.8 18.4 17.6 21.5 20.7 21.9 21.2 15.6 22.7 0.8 20.5 31.5 36.4 27.6 15.6 67.8 71.1 70.3 119.1 70.0 77.6 83.5 55.0 83.7 48.4 69.1 70.1 10.3 16.0 16.2 26.1 38.8 11.9 41.8 82.7 24.5 95.6 18.8 21.2 449.0 72.9 34.4 73.5 62.6 35.9 10.7 62.1 240.7 51.9 166.7 17.8 9.3 16.7 19.7 39.5 47.4 30.8 18.1 23.5 76.9 21.5 31.8 20.2 17.2 191.8 31.6 75.7 63.3 45.3 54.9 12.4 6.9 24.1 11.1 13.0 49.8 13.1 10.5 36.6 6.2 21.1 37.2 27.6 34.4 14.3 22.4 13.1 97.0 163.3 27.9 76.5 13.1 15.2 20.5 116.7 10.4 40.9 10.4 55.1 14.6 47.0 66.4 42.3 GOT1L1 MGC33309 ENSG00000169154 "Glutamic-oxaloacetic transaminase 1 like 1" Q8NHS2 8 37934281-37940124 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Aminotransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in single" 25 "testis: 14.1" "Cell type enriched" "Detected in some" 5 "Early spermatids: 137.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected" "Not detected" HPA028778 Uncertain NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 23: Spermatids - Flagellum & Golgi organization" "HPA028778: AB_10602138" "unprognostic (6.93e-3)" "unprognostic (5.46e-1)" 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.1 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 137.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 24.5 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.8 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GOT2 "KAT4, KATIV, KYAT4, mitAAT" ENSG00000125166 "Glutamic-oxaloacetic transaminase 2" P00505 16 58707131-58734342 "Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Lipid transport, Transport" "Aminotransferase, Transferase" "Cancer-related genes, Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 698.4;tongue: 726.8" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 341.9;Hepatocytes: 176.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018139, HPA058537" Enhanced "Intracellular and membrane" NA NA 2800000 "Cluster 13: T-cells - Unknown function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 54: Cardiomyocytes - Muscle contraction" "HPA018139: AB_1849903, HPA058537: " "unprognostic (1.50e-2)" "unprognostic (4.79e-2)" "unprognostic (2.73e-3)" "unprognostic (2.63e-3)" "unprognostic (3.02e-2)" "prognostic unfavorable (1.61e-4)" "prognostic favorable (5.75e-5)" "unprognostic (1.12e-2)" "unprognostic (3.19e-1)" "unprognostic (3.72e-2)" "unprognostic (2.27e-1)" "unprognostic (3.00e-1)" "prognostic favorable (2.90e-9)" "unprognostic (1.16e-1)" "unprognostic (1.48e-1)" "unprognostic (5.56e-2)" "unprognostic (2.22e-1)" 19.6 73.9 52.4 27.4 55.9 21.1 36.3 62.5 66.9 34.1 129.4 57.6 37.4 36.5 66.3 66.9 46.7 24.1 313.2 57.9 59.3 88.0 321.4 25.2 35.6 60.6 51.0 29.4 33.2 98.6 46.7 24.7 62.5 59.0 65.0 91.4 47.7 65.7 698.4 41.1 35.7 46.7 50.1 28.5 54.9 28.9 58.7 35.9 42.6 726.8 57.0 57.0 45.1 61.0 137.2 182.4 93.8 114.8 66.6 59.8 122.0 101.4 108.8 197.6 107.7 158.9 120.1 302.3 117.3 114.6 86.5 195.5 203.2 199.2 250.1 83.1 182.0 81.4 92.1 179.3 84.2 132.3 71.9 58.4 110.9 125.2 108.2 112.4 201.8 141.9 167.0 30.6 102.2 122.5 164.0 128.0 127.7 90.8 338.0 177.8 142.7 291.1 187.9 197.7 148.2 107.6 195.2 208.5 74.8 84.2 105.5 42.7 82.3 71.4 129.3 56.2 132.4 69.9 68.6 247.4 76.7 130.9 73.8 4.6 20.6 7.4 28.3 16.9 43.7 26.5 33.1 34.1 34.7 22.3 30.1 28.4 1.8 30.2 18.4 30.0 48.7 31.2 52.4 55.9 62.5 66.9 57.9 59.3 60.6 51.0 62.5 50.1 58.7 61.0 15.1 9.6 15.8 11.8 19.8 32.0 37.0 39.4 34.1 34.5 27.5 16.3 341.9 22.8 22.5 36.8 77.2 42.6 11.8 42.6 56.7 50.8 4.0 30.4 20.0 23.8 20.5 39.3 24.7 42.5 38.8 21.1 30.1 25.4 14.5 37.5 23.2 176.1 39.1 20.2 27.1 33.5 26.4 17.0 15.1 8.1 18.0 13.5 24.9 5.6 12.7 16.1 8.2 11.6 17.6 40.3 13.3 22.6 39.2 38.2 27.6 63.2 17.5 48.9 0.0 15.2 24.0 11.9 15.0 68.9 30.0 23.7 17.4 36.4 54.4 69.6 GPAM "GPAT1, KIAA1560, MGC26846" ENSG00000119927 "Glycerol-3-phosphate acyltransferase, mitochondrial" Q9HCL2 10 112149865-112215377 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adipose tissue: 305.7;liver: 144.1" "Cell type enhanced" "Detected in many" "Astrocytes: 90.8;Hepatocytes: 184.5;Horizontal cells: 45.4" "Cancer enriched" "Detected in all" 5 "liver cancer: 20.5" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in all" "ASC diff: 250.3;Hep G2: 71.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA046339, HPA060090" Approved Approved Mitochondria NA NA "Cluster 24: B-cells - Unknown function" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 2: Hepatocytes - Metabolism" Mitochondria "HPA046339: AB_2679627, HPA060090: AB_2684202" "unprognostic (1.82e-1)" "unprognostic (6.28e-2)" "unprognostic (1.13e-1)" "unprognostic (1.30e-1)" "unprognostic (6.80e-2)" "unprognostic (8.75e-2)" "unprognostic (1.40e-2)" "unprognostic (2.16e-2)" "unprognostic (4.59e-1)" "unprognostic (4.80e-1)" "unprognostic (2.37e-2)" "unprognostic (5.44e-2)" "prognostic favorable (4.54e-6)" "unprognostic (2.84e-1)" "unprognostic (4.41e-2)" "unprognostic (2.52e-2)" "unprognostic (1.37e-1)" 305.7 33.9 14.9 4.8 17.1 3.4 67.7 12.2 14.0 3.0 6.9 6.4 4.0 4.2 75.1 2.9 3.1 6.0 12.3 12.4 13.0 4.4 144.1 4.1 4.6 12.9 16.0 5.3 5.0 4.3 2.1 3.0 12.1 3.9 4.7 5.1 17.2 5.3 8.3 3.2 6.1 4.9 11.5 2.9 4.9 5.6 15.7 3.6 12.4 8.8 4.3 4.8 2.6 10.5 9.9 7.4 9.7 12.9 250.3 9.1 12.7 9.2 10.5 6.6 5.1 17.3 5.7 6.9 5.0 6.5 6.1 12.3 15.5 7.9 12.3 5.0 8.4 6.4 7.9 71.8 7.7 11.2 3.4 43.8 13.1 11.7 23.6 49.7 5.8 9.7 8.5 6.1 7.7 5.6 9.6 8.8 8.1 5.6 10.1 9.7 25.4 5.1 4.3 6.8 4.1 12.1 12.8 6.1 14.5 8.9 6.3 4.0 4.4 7.5 4.6 9.4 14.8 6.1 7.3 14.3 8.8 9.8 5.8 0.0 0.3 0.1 0.7 0.4 0.9 0.5 0.5 0.5 0.4 1.1 0.5 0.9 0.0 0.3 0.3 0.6 0.6 0.3 14.9 17.1 12.2 14.0 12.4 13.0 12.9 16.0 12.1 11.5 15.7 10.5 9.1 9.6 27.1 90.8 5.2 0.4 0.8 1.6 4.6 5.3 8.1 8.4 18.9 20.0 4.3 5.5 10.4 5.2 4.3 1.7 1.9 2.7 0.5 5.1 10.0 5.0 1.2 12.2 8.2 3.3 2.9 5.1 3.6 4.2 2.5 12.7 6.4 184.5 3.1 45.4 9.4 3.0 0.0 9.3 1.0 0.9 5.3 1.9 1.8 10.3 1.4 6.1 3.1 10.1 10.1 3.4 2.7 12.0 6.4 1.1 3.7 3.3 4.7 9.1 6.6 4.3 6.6 4.0 3.2 5.4 0.1 1.9 3.3 8.6 5.0 0.6 GPAT2 CT123 ENSG00000186281 "Glycerol-3-phosphate acyltransferase 2, mitochondrial" Q6NUI2 2 96021946-96039451 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in many" 5 "Breast glandular cells: 84.5;Sertoli cells: 98.6;Smooth muscle cells: 30.3;Spermatocytes: 64.4;Spermatogonia: 45.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in some" "BJ: 8.2;BJ hTERT+ SV40 Large T+: 19.6;BJ hTERT+ SV40 Large T+ RasG12V: 11.6;OE19: 13.9;U-2 OS: 10.9" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA036841 Uncertain Approved Mitochondria NA NA "Cluster 24: B-cells - Unknown function" "Cluster 43: Testis - Unknown function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 30: Mammary glandular cells - Lactation" Mitochondria "HPA036841: AB_10601479" "unprognostic (1.42e-2)" "unprognostic (2.39e-2)" "unprognostic (6.69e-2)" "unprognostic (3.83e-1)" "unprognostic (1.44e-1)" "unprognostic (2.38e-3)" "unprognostic (4.99e-2)" "unprognostic (3.28e-2)" "unprognostic (1.70e-1)" "unprognostic (1.44e-2)" "unprognostic (5.96e-2)" "unprognostic (4.67e-2)" "unprognostic (7.43e-6)" "unprognostic (2.11e-1)" "unprognostic (7.68e-2)" "unprognostic (3.49e-1)" "unprognostic (3.65e-1)" 5.8 0.8 1.5 1.4 1.7 1.2 4.5 1.4 1.7 2.4 3.3 1.8 0.2 1.5 3.1 0.8 1.6 1.6 7.4 1.2 1.3 1.6 1.0 1.3 2.4 1.7 1.6 1.2 1.6 0.1 0.6 1.4 2.0 1.1 1.0 0.2 2.2 2.8 2.1 1.1 2.2 1.6 1.3 4.6 2.1 7.6 2.4 0.8 1.7 3.0 1.9 2.0 1.4 2.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 8.2 0.0 19.6 11.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.4 0.0 0.0 0.0 0.4 0.0 2.8 0.0 0.0 0.3 0.0 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 13.9 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 10.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.2 1.0 0.7 1.0 1.6 0.5 0.7 0.4 2.4 0.3 1.1 0.0 0.1 1.0 0.0 0.5 0.6 1.5 1.7 1.4 1.7 1.2 1.3 1.7 1.6 2.0 1.3 2.4 2.1 12.9 0.0 1.1 0.3 3.5 1.0 1.1 0.7 0.6 0.7 84.5 3.4 1.3 1.5 0.5 1.8 0.0 0.1 1.7 3.1 1.9 2.2 1.9 0.1 0.5 6.5 0.0 0.8 1.0 2.0 0.6 3.3 1.5 0.5 1.3 0.2 10.8 0.0 2.4 8.4 0.4 0.6 0.0 0.8 2.1 5.3 0.6 1.5 1.8 1.9 0.7 1.0 1.0 0.0 1.4 0.8 1.3 0.0 3.6 0.4 0.0 0.2 0.2 0.4 98.6 3.2 30.3 64.4 45.3 0.4 0.1 0.1 2.2 0.3 2.1 1.8 GPAT3 "AGPAT10, AGPAT9, HMFN0839, LPAAT-theta, MAG1, MGC11324" ENSG00000138678 "Glycerol-3-phosphate acyltransferase 3" Q53EU6 4 83535914-83605875 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "kidney: 88.4" "Cell type enhanced" "Detected in many" "Basal prostatic cells: 60.0;Early spermatids: 82.3;Macrophages: 60.5;Proximal enterocytes: 56.2;Proximal tubular cells: 67.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in many" "basophil: 182.5" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "CAPAN-2: 157.6;GAMG: 116.4;HMC-1: 57.4;U-87 MG: 66.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA029414 Approved NA NA "Cluster 38: Basophils - Unknown function" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 41: Macrophages - Immune response" "HPA029414: AB_10601562" "unprognostic (9.51e-2)" "unprognostic (1.43e-2)" "unprognostic (5.67e-2)" "unprognostic (1.70e-1)" "unprognostic (3.50e-3)" "unprognostic (2.61e-2)" "unprognostic (2.05e-1)" "unprognostic (1.25e-1)" "unprognostic (1.09e-2)" "unprognostic (4.30e-2)" "unprognostic (1.12e-1)" "unprognostic (2.92e-1)" "prognostic favorable (2.71e-9)" "unprognostic (3.74e-1)" "unprognostic (3.45e-2)" "unprognostic (2.53e-3)" "prognostic unfavorable (8.21e-4)" 14.0 1.0 0.9 5.7 1.1 11.9 6.5 3.9 2.7 5.5 8.9 13.7 39.9 3.7 1.2 8.3 3.6 8.6 25.3 1.0 2.8 88.4 18.1 4.2 2.0 5.5 3.4 16.1 1.2 23.2 5.0 1.5 5.5 1.6 11.1 1.2 3.5 3.6 37.6 2.6 35.6 3.5 2.0 4.7 15.2 7.4 2.7 1.7 19.8 12.5 2.1 6.0 6.3 1.8 30.6 29.6 0.0 0.4 1.5 3.7 0.6 2.4 4.3 0.6 0.6 2.2 157.6 0.0 3.2 5.9 116.4 6.8 14.3 2.8 0.5 2.1 6.7 0.0 9.2 29.7 4.2 8.9 57.4 2.0 0.2 1.1 3.5 11.5 15.0 8.5 25.1 23.7 0.6 3.1 2.3 2.2 0.7 45.6 12.5 0.3 6.7 11.6 29.8 2.0 0.7 0.0 5.8 6.1 17.3 1.6 1.2 1.6 0.7 6.9 12.3 6.9 28.9 1.1 2.2 0.0 66.4 17.6 52.2 182.5 33.2 4.0 0.6 27.8 6.0 0.1 3.5 2.0 81.4 0.1 2.5 1.2 91.1 1.6 23.6 0.3 2.3 10.4 0.9 1.1 3.9 2.7 1.0 2.8 5.5 3.4 5.5 2.0 2.7 1.8 4.8 6.4 6.8 0.0 1.3 0.0 60.0 0.0 8.0 0.8 10.2 4.1 0.0 4.3 5.0 11.0 0.0 0.4 0.8 18.6 15.6 4.8 82.3 1.0 1.1 5.4 1.2 6.1 0.0 6.8 1.3 5.5 34.7 2.4 7.6 0.8 7.5 13.2 14.8 5.0 0.0 9.9 0.0 11.3 0.0 21.7 1.2 60.5 0.0 0.0 28.7 0.1 1.0 0.0 0.0 10.4 6.7 0.7 1.2 32.4 56.2 67.4 1.5 0.3 6.6 5.8 1.7 10.6 1.9 5.2 0.0 1.0 7.3 4.9 3.6 28.9 GPAT4 "AGPAT6, DKFZp586M1819, LPAAT-zeta, TSARG7" ENSG00000158669 "Glycerol-3-phosphate acyltransferase 4" Q86UL3 8 41577187-41625001 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016471 Approved NA NA "Cluster 44: Non-specific - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 30: Mammary glandular cells - Lactation" "HPA016471: AB_1844649" "unprognostic (3.05e-2)" "unprognostic (4.05e-2)" "unprognostic (4.24e-2)" "prognostic unfavorable (9.37e-4)" "unprognostic (7.45e-2)" "unprognostic (2.99e-3)" "unprognostic (5.08e-2)" "unprognostic (5.11e-2)" "unprognostic (3.79e-2)" "prognostic unfavorable (2.20e-4)" "unprognostic (1.98e-2)" "prognostic favorable (4.15e-4)" "unprognostic (1.73e-3)" "unprognostic (3.16e-2)" "unprognostic (3.35e-1)" "unprognostic (2.04e-2)" "prognostic favorable (5.65e-4)" 23.6 33.6 13.5 28.0 15.3 28.4 42.4 29.7 17.6 24.7 25.0 21.3 19.7 28.6 12.8 16.3 21.0 23.1 20.4 13.4 15.0 30.1 32.7 23.9 22.3 16.2 16.5 23.0 23.1 40.5 16.2 27.2 15.6 18.3 21.7 15.4 25.4 20.3 57.6 18.4 19.0 33.2 15.4 21.2 26.8 24.2 15.7 22.1 20.0 39.9 27.4 24.6 18.8 16.8 39.0 42.4 49.7 38.9 53.1 64.1 43.7 82.7 70.8 61.4 63.6 28.7 76.1 53.8 56.6 68.7 75.4 22.0 58.7 37.3 78.8 58.0 32.4 63.0 49.0 26.5 31.0 6.8 87.1 40.6 26.9 64.0 23.0 52.5 64.1 52.7 47.9 61.5 63.4 16.5 60.0 17.3 53.1 71.3 22.5 34.7 49.8 29.2 36.4 57.5 32.4 44.7 32.2 43.9 89.1 56.5 60.9 42.4 47.0 63.0 43.8 73.0 62.6 33.0 47.9 58.7 51.9 36.9 63.1 16.0 17.0 7.8 12.5 15.9 11.6 8.6 9.6 12.6 21.0 9.9 8.5 8.5 3.8 5.8 14.3 8.0 9.7 13.8 13.5 15.3 29.7 17.6 13.4 15.0 16.2 16.5 15.6 15.4 15.7 16.8 20.0 3.2 31.2 0.0 14.5 0.0 13.2 0.0 11.4 16.9 50.2 19.6 0.0 27.1 13.6 11.0 10.4 33.9 18.4 10.8 3.9 41.3 40.6 14.1 19.4 21.7 17.0 21.5 0.0 39.8 42.5 13.1 27.0 29.2 2.5 21.2 18.2 62.4 27.1 15.2 0.0 14.2 0.0 28.1 0.0 58.7 12.8 31.7 0.0 0.0 31.2 11.8 9.2 0.0 0.0 44.9 11.3 10.5 23.9 27.7 13.3 28.2 5.8 15.1 6.6 20.3 11.6 4.3 14.8 10.1 0.0 40.4 16.7 23.0 11.1 18.2 GPHN KIAA1385 ENSG00000171723 Gephyrin Q9NQX3 14 66507407-67181803 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Molybdenum cofactor biosynthesis" "Multifunctional enzyme, Transferase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 62.4" "Group enriched" "Detected in many" 4 "Astrocytes: 493.0;Excitatory neurons: 686.5;Inhibitory neurons: 866.7;Oligodendrocyte precursor cells: 576.1;Oligodendrocytes: 597.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003116, CAB004419, HPA024694" Enhanced Approved Vesicles,Cytosol NA NA 6900 "Cluster 16: MAIT-cells - Unknown function" "Cluster 15: Liver - Metabolism" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Vesicles Cytosol "CAB004419: AB_627670, HPA003116: AB_1078963, HPA024694: AB_1849616" "unprognostic (8.37e-2)" "unprognostic (2.53e-2)" "unprognostic (2.42e-1)" "unprognostic (1.20e-1)" "unprognostic (5.14e-2)" "unprognostic (4.89e-3)" "unprognostic (8.29e-2)" "unprognostic (1.41e-2)" "unprognostic (1.42e-1)" "unprognostic (2.23e-1)" "unprognostic (2.49e-2)" "unprognostic (8.54e-2)" "prognostic favorable (5.25e-12)" "unprognostic (9.81e-2)" "unprognostic (2.27e-1)" "unprognostic (7.50e-2)" "prognostic unfavorable (4.61e-5)" 13.8 11.1 35.5 3.5 36.0 2.6 13.4 48.4 54.1 9.7 20.9 11.8 7.4 9.9 11.6 12.2 11.1 6.2 17.1 36.1 37.6 25.3 62.4 9.3 3.8 32.7 35.3 8.9 23.9 11.7 13.6 3.6 32.3 11.3 10.1 23.1 9.4 6.6 24.5 15.2 9.0 6.2 32.4 6.7 14.7 6.2 34.6 5.8 11.9 13.8 4.3 11.4 10.7 39.5 39.9 8.8 13.7 15.9 14.2 17.5 9.5 11.1 5.7 12.7 12.2 2.8 17.9 0.0 1.8 7.7 5.5 13.1 17.0 19.9 18.9 15.0 14.9 15.8 9.4 22.3 7.8 9.1 15.8 13.3 13.8 2.9 16.0 4.8 11.8 13.8 9.3 14.2 7.1 19.2 11.9 22.2 5.0 28.3 17.0 0.0 32.5 13.2 16.7 7.5 25.8 10.3 10.2 31.6 12.4 3.3 18.5 11.5 6.7 14.1 24.8 11.3 13.0 22.8 9.1 0.3 10.5 0.8 11.2 0.0 0.7 0.3 2.0 1.2 3.2 1.2 2.5 1.7 1.1 1.9 1.7 1.6 0.0 1.3 1.0 1.5 3.0 0.7 35.5 36.0 48.4 54.1 36.1 37.6 32.7 35.3 32.3 32.4 34.6 39.5 11.5 6.4 13.1 493.0 11.8 4.7 9.2 5.8 27.9 34.3 12.4 6.7 12.7 8.6 10.8 1.8 52.1 3.9 3.5 8.6 13.7 4.0 3.8 7.2 13.5 10.7 6.0 7.6 686.5 5.3 2.3 8.7 19.9 13.6 0.0 3.9 15.7 47.6 3.7 43.7 866.7 15.0 8.2 5.8 1.7 5.0 11.1 4.5 1.8 148.0 1.3 8.9 1.0 576.1 597.5 3.1 7.8 5.7 15.1 11.5 7.1 20.1 2.4 34.9 0.0 12.5 11.8 11.8 8.9 26.7 5.8 2.1 7.9 9.0 10.4 6.5 GPT "ALT1, GPT1" ENSG00000167701 "Glutamic--pyruvic transaminase" P24298 8 144502973-144507174 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Aminotransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 179.6" "Cell type enhanced" "Detected in many" "Distal enterocytes: 176.9;Hepatocytes: 237.3;Paneth cells: 88.4;Proximal enterocytes: 139.7;Proximal tubular cells: 164.9" "Cancer enriched" "Detected in many" 7 "liver cancer: 38.6" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "Hep G2: 2.5;Karpas-707: 2.8;U-266/70: 2.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031059, HPA031060, CAB032997, CAB032999" Enhanced NA NA 17000000 "Cluster 7: Monocytes - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 29: U-266 - Adaptive immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "CAB032997: AB_2261949, CAB032999: AB_2095427, HPA031059: AB_10600214, HPA031060: AB_10602178" "unprognostic (8.22e-3)" "unprognostic (2.52e-2)" "unprognostic (2.39e-1)" "unprognostic (1.89e-1)" "unprognostic (3.38e-1)" "unprognostic (1.37e-2)" "prognostic favorable (1.47e-5)" "unprognostic (9.42e-2)" "unprognostic (2.19e-1)" "unprognostic (1.32e-1)" "unprognostic (4.41e-1)" "unprognostic (9.22e-2)" "prognostic favorable (2.19e-4)" "unprognostic (2.83e-2)" "unprognostic (2.82e-1)" "unprognostic (1.23e-1)" "unprognostic (1.98e-2)" 22.6 2.4 2.2 4.6 1.9 2.3 12.5 3.3 4.7 0.7 3.5 36.0 18.3 0.5 0.4 2.4 1.3 2.4 40.3 2.1 0.4 13.9 179.6 0.4 0.3 0.8 0.5 1.1 10.3 1.4 2.9 0.1 0.6 1.8 5.8 0.6 14.6 1.2 50.1 17.1 18.0 0.4 0.2 0.6 15.0 2.6 0.9 0.0 0.9 24.3 0.2 0.6 1.3 0.9 0.2 0.8 0.2 0.5 0.4 0.0 0.6 0.4 0.0 0.0 0.0 0.2 0.9 0.4 0.3 0.0 0.0 2.1 0.0 0.0 0.0 0.7 1.3 0.3 1.5 2.5 0.0 0.0 0.3 0.0 0.2 0.0 0.0 0.3 0.0 0.4 0.2 2.8 0.0 1.3 0.4 0.4 0.3 0.6 0.5 0.5 0.1 1.5 0.0 0.9 0.5 0.8 0.2 0.7 0.1 0.1 1.9 0.1 0.2 0.1 0.6 0.7 0.1 2.9 0.2 0.2 0.4 0.9 0.2 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 2.2 1.9 3.3 4.7 2.1 0.4 0.8 0.5 0.6 0.2 0.9 0.9 0.2 0.0 0.0 14.4 5.3 1.7 1.3 1.2 0.6 0.9 14.1 4.6 8.5 34.3 1.8 7.3 0.0 0.0 0.4 176.9 21.5 1.1 16.5 0.5 0.4 1.1 2.4 43.2 0.8 2.4 3.3 0.3 51.0 0.7 8.9 0.3 14.3 237.3 0.1 3.3 0.5 30.4 0.0 14.4 2.1 48.1 0.6 1.2 1.8 1.0 0.1 15.6 0.0 2.0 0.0 1.3 88.4 0.4 0.1 1.2 139.7 164.9 0.5 2.0 0.0 2.0 0.4 1.0 0.6 2.4 4.5 0.0 1.8 0.4 62.1 1.6 GPT2 ALT2 ENSG00000166123 "Glutamic--pyruvic transaminase 2" Q8TD30 16 46884362-46931289 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Aminotransferase, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "pancreas: 267.4;skeletal muscle: 176.4;tongue: 184.5" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 64.3;Hepatocytes: 123.9;Syncytiotrophoblasts: 83.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "memory B-cell: 1.3;naive B-cell: 1.0" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "Hep G2: 159.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA051514 Approved Approved Mitochondria No No "Cluster 19: B-cells - Humoral immune response" "Cluster 80: Striated muscle - Unknown function" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Mitochondria "HPA051514: AB_2681516" "unprognostic (1.65e-2)" "unprognostic (3.32e-2)" "unprognostic (2.87e-1)" "unprognostic (3.87e-2)" "unprognostic (3.41e-1)" "unprognostic (1.27e-1)" "unprognostic (1.95e-3)" "unprognostic (3.44e-2)" "unprognostic (6.12e-2)" "prognostic favorable (3.17e-4)" "unprognostic (1.90e-1)" "unprognostic (1.30e-1)" "unprognostic (1.56e-1)" "unprognostic (1.44e-2)" "unprognostic (4.86e-1)" "unprognostic (3.54e-3)" "unprognostic (3.18e-1)" 56.8 10.4 51.6 4.0 49.9 3.8 17.0 49.1 56.9 5.2 38.4 7.7 1.7 3.7 31.4 77.8 7.6 9.8 7.9 51.3 45.7 23.5 103.7 2.1 4.3 69.8 45.9 2.3 267.4 8.3 13.0 3.1 63.9 24.2 4.9 6.9 48.8 10.9 176.4 37.8 3.9 3.1 60.2 2.3 58.6 15.0 54.9 7.7 7.6 184.5 13.4 2.7 7.7 64.5 42.6 19.0 23.8 90.6 32.7 7.0 43.1 28.9 10.9 30.7 19.2 65.3 17.6 29.9 24.7 20.7 15.6 33.6 43.3 42.8 20.4 14.0 21.1 10.5 10.8 159.9 22.4 75.6 9.5 15.2 37.0 30.0 46.3 20.3 15.1 56.1 8.7 23.3 10.3 75.8 15.1 62.9 25.3 52.2 54.2 0.3 26.3 71.1 12.4 21.0 73.7 37.7 14.9 76.4 39.0 9.4 19.6 67.6 11.3 21.1 40.9 14.2 23.4 110.2 36.9 87.1 32.6 48.3 11.7 0.4 0.2 0.0 0.1 0.0 0.0 1.3 0.0 0.1 0.4 1.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 51.6 49.9 49.1 56.9 51.3 45.7 69.8 45.9 63.9 60.2 54.9 64.5 1.3 6.4 3.4 54.9 4.8 15.9 4.9 6.8 64.3 14.5 6.7 8.4 14.9 8.6 9.1 18.4 22.9 9.2 0.3 10.2 11.7 7.0 9.6 12.2 7.2 2.3 13.1 5.2 16.7 30.2 44.8 7.5 37.2 37.5 3.8 14.9 5.0 123.9 3.8 6.7 18.8 13.4 6.1 3.2 7.3 22.9 4.7 2.3 8.8 1.0 1.1 42.5 1.0 13.6 26.0 25.6 5.2 15.4 7.9 12.4 2.0 38.6 5.4 5.9 0.0 5.2 3.6 2.5 17.3 53.1 16.3 83.3 1.4 2.6 6.3 4.2 GRK1 "GPRK1, RHOK, RK" ENSG00000185974 "G protein-coupled receptor kinase 1" Q15835 13 113667219-113737736 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Sensory transduction, Vision" "Kinase, Serine/threonine-protein kinase, Transferase" "Congenital stationary night blindness, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 50 "retina: 42.6" "Group enriched" "Detected in some" 16 "Cone photoreceptor cells: 56.3;Rod photoreceptor cells: 84.9" "Cancer enriched" "Detected in single" 5 "thyroid cancer: 0.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA035200, HPA059376" Enhanced NA NA "Cluster 79: Retina - Phototransduction" "Cluster 46: Photoreceptor cells - Phototransduction" "HPA035200: AB_2674515, HPA059376: AB_2683996" "unprognostic (7.93e-2)" "unprognostic (2.50e-1)" "unprognostic (1.87e-1)" "unprognostic (1.24e-5)" "unprognostic (1.76e-3)" "unprognostic (1.53e-1)" "unprognostic (3.59e-2)" "unprognostic (2.21e-2)" "unprognostic (1.84e-3)" "unprognostic (2.00e-2)" "unprognostic (4.02e-2)" "unprognostic (6.91e-2)" "unprognostic (6.18e-2)" "unprognostic (6.11e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 42.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.6 0.0 0.0 0.0 56.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 4.4 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 84.9 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GRK2 "ADRBK1, BARK1" ENSG00000173020 "G protein-coupled receptor kinase 2" P25098 11 67266473-67286556 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 197.1" "Cell type enhanced" "Detected in many" "Adipocytes: 33.4;dendritic cells: 80.2;Hofbauer cells: 35.8;Macrophages: 37.6;Pancreatic endocrine cells: 32.4;T-cells: 31.0;Theca cells: 36.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "NB-4: 318.0;REH: 417.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005021, CAB037248, HPA060707" Enhanced Approved Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 2: Immune cells - Immune response" "Cluster 14: REH - Unknown function" "Cluster 7: Non-specific - Mitochondria" Cytosol "CAB005021: AB_562360, CAB037248: AB_1078280, HPA060707: " "unprognostic (5.58e-2)" "unprognostic (1.75e-1)" "unprognostic (2.01e-2)" "unprognostic (5.33e-2)" "unprognostic (1.38e-1)" "unprognostic (1.29e-3)" "unprognostic (3.31e-2)" "unprognostic (6.17e-2)" "unprognostic (1.11e-1)" "unprognostic (6.35e-2)" "unprognostic (2.22e-1)" "unprognostic (2.55e-2)" "prognostic unfavorable (1.25e-4)" "unprognostic (3.66e-1)" "unprognostic (2.40e-1)" "unprognostic (4.04e-2)" "unprognostic (5.19e-3)" 41.2 35.6 42.4 73.0 42.7 197.1 38.0 31.6 63.8 41.3 16.9 54.3 38.2 34.7 10.4 68.1 41.6 28.8 49.1 44.4 32.5 38.6 47.4 64.1 102.4 36.4 31.6 30.1 33.1 16.2 37.5 25.5 36.5 59.1 33.3 7.9 47.1 22.8 55.6 68.3 88.7 25.1 29.1 186.8 45.4 24.1 36.9 74.7 32.2 40.9 77.8 41.3 47.4 41.8 43.1 29.8 28.1 48.0 22.2 19.9 28.7 24.7 23.4 33.0 27.4 67.1 69.0 215.3 39.5 23.0 44.0 56.7 41.3 33.5 17.2 264.4 26.3 122.5 35.4 30.8 27.9 259.5 238.3 18.0 38.2 26.5 34.8 24.4 42.8 87.7 45.3 107.7 29.0 80.7 147.5 318.0 35.3 125.8 44.4 417.0 55.3 65.2 34.0 54.6 57.0 30.8 36.9 52.9 90.5 16.9 49.7 283.0 24.5 26.7 34.8 33.6 28.4 69.2 67.5 195.3 34.0 153.6 24.6 12.6 17.8 19.2 8.4 27.6 6.3 6.1 6.3 7.0 10.2 6.4 5.0 4.9 35.7 6.9 33.7 9.0 4.4 15.9 42.4 42.7 31.6 63.8 44.4 32.5 36.4 31.6 36.5 29.1 36.9 41.8 33.4 3.2 17.9 0.0 16.7 0.0 0.0 0.0 0.0 0.0 24.5 19.7 0.0 0.0 4.3 5.5 0.0 8.9 80.2 0.0 1.9 10.3 0.0 16.6 14.7 9.0 0.0 0.0 0.0 12.6 5.9 6.1 0.0 18.9 21.5 22.3 0.0 0.0 35.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 37.6 0.0 0.0 8.8 0.0 0.0 0.0 0.0 32.4 0.0 0.0 17.7 0.0 0.0 5.6 0.7 0.0 0.0 0.0 10.0 0.0 0.0 0.0 0.0 9.6 31.0 36.3 0.0 0.0 GRK3 "ADRBK2, BARK2" ENSG00000100077 "G protein-coupled receptor kinase 3" P35626 22 25564675-25729294 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 30.2" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 32.2;Club cells: 16.7;Extravillous trophoblasts: 29.2;granulocytes: 18.9;Hofbauer cells: 29.3;Macrophages: 26.4;monocytes: 27.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 9 "classical monocyte: 4.1;eosinophil: 5.2;intermediate monocyte: 7.2;memory B-cell: 4.1;myeloid DC: 3.2;naive B-cell: 5.0;non-classical monocyte: 6.8;plasmacytoid DC: 2.7" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HDLM-2: 43.6;JURKAT: 69.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000804 Uncertain Approved "Nucleoplasm,Plasma membrane" NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 2: Immune cells - Immune response" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 41: Macrophages - Immune response" Nucleoplasm "Plasma membrane" "HPA000804: AB_1078281" "unprognostic (1.02e-1)" "unprognostic (4.38e-2)" "unprognostic (5.68e-3)" "unprognostic (4.33e-2)" "unprognostic (2.09e-1)" "unprognostic (3.67e-2)" "unprognostic (3.29e-1)" "unprognostic (1.78e-2)" "unprognostic (1.97e-1)" "unprognostic (3.54e-1)" "unprognostic (1.95e-3)" "unprognostic (5.79e-2)" "unprognostic (1.01e-3)" "unprognostic (1.74e-1)" "unprognostic (2.87e-3)" "unprognostic (1.89e-2)" "prognostic favorable (1.29e-4)" 30.2 5.4 6.5 12.9 8.9 7.8 9.4 2.3 14.7 4.0 0.0 3.1 2.8 5.3 1.3 2.4 8.7 4.7 4.3 18.9 2.6 2.4 3.2 9.4 15.1 5.4 6.2 2.9 7.1 4.2 3.2 4.4 2.5 7.5 3.9 4.8 3.2 1.6 0.9 3.3 4.7 5.9 2.9 18.8 3.8 15.7 7.6 10.2 4.1 1.2 15.6 6.2 1.5 6.0 0.1 3.9 11.9 3.9 8.1 1.0 17.3 1.3 3.8 3.8 6.5 6.4 6.8 22.5 0.3 0.3 10.5 0.2 11.9 9.1 11.1 43.6 7.6 10.3 1.3 14.3 0.3 33.8 16.8 2.0 6.2 2.6 4.6 0.6 0.7 69.4 1.1 0.1 4.4 5.6 24.4 2.4 8.5 12.1 0.0 10.8 18.9 3.8 0.0 6.6 27.6 37.5 2.2 0.1 9.0 10.9 3.3 13.4 0.3 0.1 23.6 0.2 4.9 2.6 9.1 17.4 15.8 11.8 3.7 0.5 4.1 5.2 0.0 7.2 0.2 4.1 0.0 0.2 3.2 5.0 0.1 0.1 0.2 0.0 6.8 2.7 0.3 1.5 6.5 8.9 2.3 14.7 18.9 2.6 5.4 6.2 2.5 2.9 7.6 6.0 3.9 16.0 32.2 0.0 10.2 0.0 0.0 0.0 0.0 0.0 11.7 9.5 0.0 0.0 16.7 0.0 0.0 2.0 1.1 0.0 1.9 9.4 0.0 12.7 5.8 2.4 0.0 0.0 0.0 1.8 29.2 4.1 0.0 2.2 18.9 3.7 0.0 0.0 29.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 26.4 0.0 0.0 27.4 0.0 0.0 0.0 0.0 3.4 0.0 0.0 2.1 0.0 0.0 1.8 6.6 0.0 0.0 0.0 5.1 0.0 0.0 0.0 0.0 3.3 1.1 5.0 0.0 0.0 GRK4 "GPRK2L, GPRK4" ENSG00000125388 "G protein-coupled receptor kinase 4" P32298 4 2963571-3040760 "Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 19.3;testis: 42.3" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 123.0;Early spermatids: 357.7;Late spermatids: 500.3;Spermatocytes: 180.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA057023 Approved Supported "Plasma membrane,Cytosol" NA NA "Cluster 17: Basophils - Unknown function" "Cluster 21: Non-specific - Transcription" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 40: Granulosa cells - Unknown function" Cytosol "Plasma membrane" "HPA057023: AB_2683313" "unprognostic (1.86e-2)" "unprognostic (2.88e-1)" "unprognostic (1.03e-1)" "unprognostic (9.51e-3)" "unprognostic (3.65e-1)" "unprognostic (1.84e-1)" "unprognostic (1.21e-1)" "unprognostic (2.39e-1)" "unprognostic (1.79e-1)" "unprognostic (1.87e-1)" "unprognostic (3.90e-4)" "unprognostic (3.20e-1)" "unprognostic (1.01e-2)" "unprognostic (4.74e-2)" "unprognostic (2.17e-1)" "unprognostic (1.17e-1)" "unprognostic (1.89e-1)" 2.8 3.3 6.2 1.1 6.2 1.3 2.4 19.3 8.4 3.0 0.3 2.8 1.0 2.7 2.3 1.8 2.1 2.4 4.9 6.5 5.7 2.2 2.0 2.0 1.2 6.0 5.5 3.5 5.4 4.4 6.2 1.6 5.7 2.0 1.4 10.1 2.9 2.1 4.8 2.3 1.4 2.1 3.6 1.4 3.0 42.3 6.4 1.6 3.3 4.4 1.2 2.3 2.2 7.2 2.3 0.8 2.7 7.9 6.3 6.1 1.6 4.3 1.9 2.4 2.1 2.3 0.7 5.1 1.9 7.1 4.8 0.7 3.6 3.6 2.1 3.4 3.4 5.6 3.2 2.6 3.8 2.3 1.9 4.1 5.7 4.3 2.0 2.7 4.7 5.5 5.4 6.6 5.8 2.6 4.8 4.8 2.1 3.3 6.0 6.1 3.4 2.1 2.3 2.9 15.2 4.8 2.7 1.2 4.1 1.9 6.0 3.5 5.5 6.6 1.7 4.5 4.0 6.5 4.0 3.8 3.3 5.0 2.2 2.1 0.3 0.6 0.3 0.7 0.4 0.3 0.2 0.2 0.1 0.3 0.5 0.4 1.1 0.5 0.2 0.7 0.1 0.4 6.2 6.2 19.3 8.4 6.5 5.7 6.0 5.5 5.7 3.6 6.4 7.2 3.9 3.2 7.4 34.6 2.1 11.2 3.2 5.0 7.4 57.1 5.0 5.5 11.4 4.3 5.6 3.7 123.0 2.1 4.7 0.8 13.7 2.7 357.7 4.2 7.2 4.2 10.3 8.6 53.9 3.8 5.3 8.7 5.1 3.8 5.7 75.0 6.1 3.0 3.4 18.5 71.1 2.4 4.1 2.9 4.6 500.3 13.1 3.1 7.2 9.4 3.0 11.4 2.1 48.2 29.3 2.1 0.4 8.2 5.3 1.8 2.0 5.0 1.2 58.2 6.6 8.4 5.7 180.4 22.3 6.5 11.4 3.0 4.0 34.6 1.3 2.4 GRK5 GPRK5 ENSG00000198873 "G protein-coupled receptor kinase 5" P34947 10 119207571-119459745 "Enzymes, Predicted intracellular proteins" "Apoptosis, Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 57.7;Microglial cells: 56.2;Sertoli cells: 59.2;Smooth muscle cells: 46.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "BJ hTERT+: 32.1;HUVEC TERT2: 24.9;OE19: 25.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025579, HPA046838" Approved Supported "Nuclear membrane,Nuclear speckles,Plasma membrane" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 21: OE19 - Mitochondria" "Cluster 50: Fibroblasts - ECM organization" "Nuclear membrane, Nuclear speckles" "Plasma membrane" "CAB025579: , HPA046838: AB_2679833" "unprognostic (1.09e-1)" "unprognostic (3.47e-1)" "unprognostic (1.19e-1)" "unprognostic (6.02e-2)" "unprognostic (6.56e-2)" "unprognostic (3.74e-2)" "unprognostic (4.62e-2)" "unprognostic (3.69e-1)" "unprognostic (4.11e-1)" "unprognostic (1.06e-1)" "unprognostic (3.70e-1)" "unprognostic (2.32e-1)" "prognostic unfavorable (2.38e-7)" "unprognostic (1.10e-1)" "unprognostic (3.27e-2)" "unprognostic (1.55e-2)" "unprognostic (1.90e-2)" 38.4 18.0 4.2 5.9 5.0 2.7 24.6 5.0 4.6 18.8 3.5 26.3 10.0 21.1 3.5 12.6 19.6 5.7 48.8 4.0 5.1 14.2 12.9 65.6 7.8 3.9 3.6 35.0 4.7 21.3 13.3 8.3 3.9 14.1 4.9 1.0 7.8 4.0 11.9 11.5 25.8 7.3 3.3 37.0 27.5 4.1 4.9 6.2 19.6 9.7 6.8 19.4 18.1 3.5 3.7 2.3 5.4 5.7 11.8 11.0 1.6 7.1 32.1 4.1 2.3 1.7 5.4 3.9 1.6 11.1 7.5 0.9 2.3 7.7 2.7 15.4 2.0 0.7 4.6 7.0 8.2 0.2 2.0 1.5 1.1 8.5 1.2 5.2 24.9 2.4 0.4 3.7 1.5 0.7 3.8 3.5 0.8 25.8 5.2 1.3 0.8 0.9 0.6 1.5 1.8 4.9 2.4 1.1 7.0 3.0 0.1 0.9 7.8 2.3 1.6 14.6 2.8 0.9 4.4 2.4 4.9 4.4 2.4 0.4 1.5 2.9 2.0 1.4 0.1 3.8 3.0 1.6 0.9 4.0 4.5 2.0 2.1 0.1 0.5 0.0 4.0 1.7 4.2 5.0 5.0 4.6 4.0 5.1 3.9 3.6 3.9 3.3 4.9 3.5 32.6 57.7 3.7 3.6 19.7 1.7 0.7 0.5 1.2 3.9 2.3 2.0 19.4 0.0 1.3 3.7 0.0 3.7 13.3 0.4 0.0 1.1 18.7 0.4 5.1 28.4 4.8 0.0 17.7 3.1 15.8 35.7 18.8 1.0 4.5 7.8 24.7 2.2 4.4 1.7 36.5 0.8 6.1 15.5 6.3 4.9 4.4 14.2 7.2 56.2 3.6 0.0 19.6 14.1 5.7 2.4 1.2 4.5 10.2 0.7 4.9 0.6 0.8 0.9 59.2 18.2 46.5 1.3 2.1 0.7 2.4 13.1 14.1 4.6 0.5 0.9 GRK6 GPRK6 ENSG00000198055 "G protein-coupled receptor kinase 6" P43250 5 177403204-177442901 "Enzymes, Predicted intracellular proteins" "Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 134.1" "Cell type enhanced" "Detected in many" "Late spermatids: 90.6;NK-cells: 123.6;Plasma cells: 112.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015327, HPA018903" Approved Approved Mitochondria NA NA 170000 "Cluster 52: Eosinophils - Transcription" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 2: Karpas-707 - Immune response" "Cluster 55: Plasma cells - Humoral immune response" Mitochondria "HPA015327: AB_1850334, HPA018903: AB_1850335" "unprognostic (1.06e-1)" "unprognostic (3.39e-2)" "unprognostic (4.46e-2)" "unprognostic (3.87e-2)" "unprognostic (2.35e-3)" "unprognostic (1.53e-1)" "prognostic unfavorable (5.66e-6)" "unprognostic (2.63e-1)" "unprognostic (6.45e-2)" "unprognostic (8.96e-2)" "prognostic favorable (1.22e-4)" "unprognostic (1.74e-2)" "unprognostic (1.99e-2)" "unprognostic (1.83e-3)" "unprognostic (1.15e-1)" "unprognostic (4.00e-2)" "unprognostic (3.47e-1)" 14.0 10.8 12.6 36.7 12.3 134.1 12.7 8.1 16.0 11.3 9.2 19.7 18.5 14.8 2.4 21.5 13.3 12.4 13.3 12.7 9.6 11.0 13.6 21.8 61.6 13.3 10.5 11.1 13.3 5.5 10.5 6.8 11.1 15.8 8.8 2.2 17.9 7.4 15.7 15.5 29.1 9.2 8.9 63.3 15.9 22.3 10.7 35.9 10.2 6.2 30.2 16.6 13.2 13.9 41.1 44.2 15.7 67.8 4.6 7.4 66.4 29.4 15.1 36.2 35.5 103.0 34.1 48.7 44.0 15.6 53.5 29.1 24.3 67.0 14.3 133.9 77.3 43.5 36.2 36.0 24.1 58.6 52.8 11.7 16.1 36.2 21.4 8.8 20.5 87.8 45.6 170.9 11.2 117.4 61.3 61.4 26.7 20.4 48.1 57.1 25.5 71.2 10.7 32.9 36.0 48.6 24.3 42.5 56.8 7.1 32.6 63.4 26.3 29.6 43.8 31.2 75.1 48.8 64.2 40.7 20.0 95.0 29.2 12.7 20.9 74.5 23.6 36.5 17.0 19.3 19.6 21.9 11.9 19.5 20.3 18.0 50.6 40.3 51.9 12.5 26.4 22.6 12.6 12.3 8.1 16.0 12.7 9.6 13.3 10.5 11.1 8.9 10.7 13.9 9.2 0.0 2.2 2.6 71.7 23.7 60.3 4.9 5.7 10.5 14.7 17.3 3.0 10.0 4.6 3.7 6.2 13.9 70.8 18.2 15.6 6.0 37.2 7.4 8.2 6.6 11.4 41.7 3.7 8.3 12.6 9.7 16.8 6.4 14.7 13.9 10.0 6.5 20.4 16.8 3.5 14.3 4.1 29.8 18.8 90.6 6.2 41.2 14.2 2.8 26.4 9.0 123.6 2.0 3.3 10.3 14.0 5.3 112.2 61.1 11.8 8.5 2.0 8.6 13.1 8.4 10.7 3.9 4.2 11.9 20.3 12.7 66.5 12.1 17.1 56.6 GRK7 GPRK7 ENSG00000114124 "G protein-coupled receptor kinase 7" Q8WTQ7 3 141778148-141818490 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Sensory transduction, Vision" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 19 "retina: 11.3" "Cell type enriched" "Detected in some" 73 "Cone photoreceptor cells: 329.4" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA075093, HPA078232" Enhanced Approved Mitochondria NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 79: Retina - Phototransduction" "Cluster 9: Photoreceptor cells - Phototransduction" Mitochondria "HPA075093: , HPA078232: " "unprognostic (1.11e-1)" "unprognostic (1.70e-2)" "unprognostic (3.35e-3)" "unprognostic (1.22e-2)" "unprognostic (1.13e-1)" "unprognostic (1.60e-1)" "unprognostic (1.39e-2)" "unprognostic (5.08e-2)" "unprognostic (1.21e-1)" "unprognostic (1.31e-2)" "unprognostic (3.46e-2)" "unprognostic (1.20e-1)" "unprognostic (2.53e-8)" "unprognostic (3.08e-1)" "unprognostic (1.99e-1)" "unprognostic (3.11e-1)" "unprognostic (2.91e-1)" 0.0 0.0 0.1 0.0 0.1 0.2 0.0 0.5 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 11.3 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.5 0.1 0.1 0.0 0.1 0.0 0.2 0.0 0.1 0.1 0.1 0.0 0.0 3.9 0.1 0.4 0.2 0.0 0.6 1.0 0.1 0.1 0.2 0.0 0.0 0.0 329.4 0.0 0.2 0.0 0.0 0.0 1.0 0.1 0.1 0.1 0.0 0.0 2.5 0.0 0.0 0.1 0.0 0.1 0.0 0.4 0.0 0.0 0.1 0.0 2.1 0.0 0.0 0.0 0.4 2.4 0.0 0.1 0.0 1.9 0.1 1.1 0.0 4.5 3.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.2 0.0 0.5 0.1 0.1 0.0 0.2 0.3 0.0 0.1 0.3 0.1 0.0 GSK3A ENSG00000105723 "Glycogen synthase kinase 3 alpha" P49840 19 42226225-42242625 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Carbohydrate metabolism, Glycogen metabolism, Neurogenesis, Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Signal transduction inhibitor, Transferase" "Alzheimer disease, Cancer-related genes, Diabetes mellitus" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004422, HPA028423" Approved Approved Cytosol NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 47: Non-specific - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 7: Non-specific - Mitochondria" Cytosol "CAB004422: AB_627680, HPA028423: AB_10612116" "unprognostic (5.46e-2)" "unprognostic (1.50e-1)" "unprognostic (1.45e-1)" "prognostic unfavorable (4.02e-4)" "unprognostic (1.35e-1)" "unprognostic (3.96e-2)" "prognostic unfavorable (1.13e-4)" "unprognostic (3.80e-3)" "unprognostic (2.27e-1)" "unprognostic (2.87e-1)" "unprognostic (4.99e-2)" "unprognostic (3.36e-1)" "unprognostic (2.69e-1)" "unprognostic (2.77e-2)" "unprognostic (4.49e-2)" "unprognostic (7.22e-2)" "unprognostic (8.22e-3)" 30.6 43.3 37.5 22.1 44.0 30.7 29.4 33.6 90.2 34.5 13.7 39.4 40.9 38.1 21.7 40.2 31.8 18.7 45.8 47.0 30.9 39.2 30.4 30.4 23.7 39.1 30.9 34.5 29.6 34.4 32.1 19.9 37.6 33.3 21.1 32.6 31.7 25.9 79.2 42.9 37.1 23.0 20.5 31.2 35.4 30.6 38.2 32.9 29.6 42.0 22.7 37.7 33.0 49.5 57.0 102.1 54.3 53.2 30.3 29.5 25.9 42.7 36.1 49.6 46.0 39.0 39.6 41.0 39.6 33.9 44.8 25.6 49.5 51.3 38.5 33.8 74.5 41.5 41.3 42.7 42.7 51.7 54.0 27.2 45.8 41.9 47.7 44.8 46.5 34.7 73.9 63.0 41.1 80.0 87.7 39.0 42.8 84.5 40.0 58.4 33.8 30.4 43.4 76.1 63.7 67.5 52.8 71.6 36.6 42.8 39.5 69.5 40.6 52.0 40.9 31.0 71.9 65.8 82.8 38.7 66.4 49.8 58.2 0.9 0.5 1.4 0.5 0.8 0.9 0.3 0.3 0.7 0.2 0.2 0.2 0.8 1.7 0.3 0.4 0.6 0.5 0.7 37.5 44.0 33.6 90.2 47.0 30.9 39.1 30.9 37.6 20.5 38.2 49.5 45.6 6.4 16.2 5.2 16.4 24.6 17.7 7.3 14.8 40.8 35.0 39.2 12.9 17.2 7.9 16.5 62.6 23.4 31.4 42.3 3.9 15.2 8.6 19.6 21.5 26.6 23.4 28.6 15.1 17.2 25.3 21.3 16.8 25.0 2.5 27.2 18.2 13.9 20.3 60.6 14.9 29.7 6.1 21.3 15.4 14.6 17.7 25.2 16.0 8.4 14.4 41.8 21.6 11.1 12.2 24.2 24.3 16.6 12.6 29.0 45.0 16.0 5.9 47.0 6.6 50.4 27.4 16.4 19.4 20.2 28.1 44.1 20.6 42.6 28.8 30.1 GSK3B ENSG00000082701 "Glycogen synthase kinase 3 beta" P49841 3 119821321-120094994 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Biological rhythms, Carbohydrate metabolism, Differentiation, Glycogen metabolism, Neurogenesis, Wnt signaling pathway" "Developmental protein, Kinase, Serine/threonine-protein kinase, Signal transduction inhibitor, Transferase" "Alzheimer disease, Diabetes mellitus" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "Excitatory neurons: 218.7;Inhibitory neurons: 246.3;Microglial cells: 197.7;Oligodendrocyte precursor cells: 241.8;Oligodendrocytes: 202.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB016263, HPA028017" Approved Supported Nucleoplasm No No "Cluster 52: Eosinophils - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 30: Epithelial cell lines - Translation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "CAB016263: AB_2279451, HPA028017: AB_10600708" "unprognostic (1.09e-2)" "unprognostic (2.62e-1)" "unprognostic (1.40e-1)" "unprognostic (2.17e-3)" "unprognostic (1.15e-1)" "unprognostic (4.86e-2)" "prognostic unfavorable (8.20e-5)" "unprognostic (3.39e-2)" "unprognostic (1.11e-1)" "unprognostic (1.67e-2)" "unprognostic (1.05e-3)" "unprognostic (6.79e-2)" "prognostic favorable (1.52e-4)" "unprognostic (2.39e-1)" "unprognostic (2.58e-1)" "unprognostic (1.28e-2)" "unprognostic (1.16e-1)" 11.0 13.6 9.2 11.7 9.5 15.1 11.2 16.6 16.9 10.0 0.0 11.7 12.3 10.3 11.1 13.8 10.1 11.1 18.2 8.2 13.8 12.0 14.8 13.9 10.4 15.2 15.3 9.3 10.7 17.3 7.1 16.3 16.5 10.0 12.4 23.6 13.2 9.3 17.5 16.3 15.3 13.3 4.9 12.9 12.6 23.1 9.6 20.0 15.1 18.0 11.7 12.0 9.5 12.5 59.3 22.7 46.8 25.5 31.9 29.5 50.3 36.6 57.6 28.3 29.3 25.9 23.8 24.1 19.1 43.0 33.8 46.0 22.2 59.1 45.8 15.5 6.6 42.2 18.4 16.6 35.6 31.6 49.9 34.3 39.5 27.0 56.8 27.3 31.5 29.3 13.6 34.6 40.5 25.1 44.0 10.7 25.2 23.3 28.3 16.9 41.0 22.2 25.1 45.3 37.1 22.6 38.5 29.0 44.1 41.1 30.9 27.0 40.0 45.5 55.1 12.7 20.6 31.9 35.2 44.8 29.4 22.0 33.9 1.0 1.8 6.3 0.7 1.6 1.2 0.5 1.0 1.7 1.4 0.7 0.9 0.8 6.6 0.5 2.1 1.1 1.2 0.8 9.2 9.5 16.6 16.9 8.2 13.8 15.2 15.3 16.5 4.9 9.6 12.5 39.3 32.1 26.7 113.6 28.3 50.9 37.8 22.2 46.1 63.2 21.9 17.0 39.7 20.0 21.4 18.4 60.5 27.0 29.0 37.3 11.7 26.9 138.2 25.2 31.6 31.5 26.9 15.4 218.7 32.0 49.3 25.1 46.4 32.5 17.2 18.1 25.0 22.9 21.5 143.0 246.3 22.3 20.3 27.3 29.2 48.1 13.1 33.4 35.6 197.7 35.5 31.6 22.6 241.8 202.5 49.0 23.4 19.9 29.0 28.7 35.8 17.3 16.3 42.4 13.1 24.4 38.2 38.8 29.3 50.8 41.1 43.0 36.4 32.7 25.9 41.6 GSTA1 ENSG00000243955 "Glutathione S-transferase alpha 1" P08263 6 52791371-52803860 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Isomerase, Oxidoreductase, Peroxidase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adrenal gland: 916.5;kidney: 943.1;liver: 2610.5" "Cell type enhanced" "Detected in many" "Exocrine glandular cells: 1652.6;Granulosa cells: 3177.1;Proximal enterocytes: 4294.8;Proximal tubular cells: 3190.6;Theca cells: 4578.2" "Cancer enriched" "Detected in many" 4 "liver cancer: 555.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 14 "Hep G2: 263.9" "HPA004342, HPA048934, HPA053817" Supported Supported Cytosol NA NA 27800000 "Cluster 85: Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 40: Granulosa cells - Unknown function" Cytosol "HPA004342: AB_1078987, HPA048934: AB_2680563, HPA053817: AB_2630367" "unprognostic (4.84e-3)" "unprognostic (2.40e-2)" "unprognostic (3.40e-1)" "unprognostic (4.78e-2)" "unprognostic (1.72e-1)" "unprognostic (1.26e-1)" "unprognostic (1.00e-2)" "prognostic favorable (8.66e-4)" "unprognostic (5.75e-2)" "unprognostic (6.90e-3)" "unprognostic (3.00e-1)" "unprognostic (8.27e-2)" "prognostic unfavorable (3.71e-4)" "unprognostic (1.21e-1)" "unprognostic (4.26e-3)" "unprognostic (1.02e-1)" "unprognostic (2.16e-2)" 0.5 916.5 0.0 2.5 0.0 0.0 4.2 0.0 0.2 2.0 0.0 7.3 672.0 0.4 7.0 5.3 86.1 119.5 0.2 0.0 0.0 943.1 2610.5 12.2 0.5 0.0 0.0 78.9 148.6 0.0 0.2 0.5 0.0 18.7 8.1 0.0 21.5 0.6 0.1 1.2 674.6 0.3 0.0 0.2 135.5 336.8 0.3 0.1 0.1 0.0 11.5 2.2 5.1 0.1 0.0 0.1 0.1 0.0 0.0 0.0 1.1 0.1 0.0 0.0 0.0 19.4 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.5 0.1 263.9 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.1 0.0 0.0 0.4 2.1 0.0 0.2 1.5 2.1 0.3 0.0 0.0 1.1 0.0 0.2 0.5 0.5 0.1 0.6 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 6.4 7.7 0.0 13.5 0.0 5.0 35.7 0.0 0.0 7.0 1.5 0.0 453.2 159.9 73.5 0.0 0.1 0.1 5.8 536.1 71.3 11.8 0.4 0.1 3.1 3.0 45.5 0.0 1652.6 0.2 7.3 116.7 0.5 2.5 3177.1 26.4 1013.9 0.1 0.0 0.0 165.6 42.7 31.5 0.0 43.0 65.6 25.3 0.0 0.0 13.3 0.0 1.0 0.0 0.1 629.1 187.4 4.5 0.2 27.6 4294.8 3190.6 533.5 0.0 0.0 0.0 98.6 36.8 3.4 6.8 0.0 0.5 10.4 4578.2 295.3 58.7 GSTA2 GST2 ENSG00000244067 "Glutathione S-transferase alpha 2" P09210 6 52750087-52763475 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "kidney: 696.0;liver: 2058.5" "Cell type enhanced" "Detected in many" "Cholangiocytes: 201.6;Distal tubular cells: 213.2;Exocrine glandular cells: 239.6;Pancreatic endocrine cells: 334.7;Proximal enterocytes: 367.0;Proximal tubular cells: 1186.6;Respiratory ciliated cells: 435.5" "Group enriched" "Detected in many" 16 "liver cancer: 124.6;renal cancer: 48.1" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 13 "CACO-2: 25.9;Hep G2: 20.0" "HPA004342, HPA048934, HPA053817" Supported Supported Cytosol NA NA "Cluster 85: Liver - Metabolism" "Cluster 39: CACO-2 - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Cytosol "HPA004342: AB_1078987, HPA048934: AB_2680563, HPA053817: AB_2630367" "unprognostic (1.14e-1)" "unprognostic (1.20e-1)" "unprognostic (2.72e-2)" "unprognostic (1.15e-1)" "unprognostic (6.43e-3)" "unprognostic (2.41e-1)" "unprognostic (1.30e-1)" "unprognostic (1.15e-1)" "prognostic unfavorable (1.17e-4)" "unprognostic (4.34e-2)" "unprognostic (1.91e-1)" "unprognostic (6.54e-2)" 0.4 4.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.6 149.5 0.0 0.7 0.1 2.5 109.4 0.0 0.0 0.0 696.0 2058.5 4.8 0.1 0.0 0.0 0.2 299.2 0.0 0.0 0.1 0.0 3.8 0.1 0.0 0.5 0.0 0.0 0.0 115.5 0.0 0.0 0.0 11.7 44.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.2 0.0 0.0 0.0 25.9 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 1.2 0.0 20.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.2 0.0 1.7 0.0 0.0 0.6 0.4 0.0 0.0 0.0 0.2 0.7 0.0 0.0 0.6 0.0 0.0 0.3 0.6 0.5 0.5 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.4 0.0 1.7 0.0 0.2 1.5 0.0 0.0 0.1 0.1 0.0 201.6 31.1 16.5 0.0 0.0 0.0 0.1 213.2 8.1 6.9 0.0 0.0 0.6 0.0 0.0 0.0 239.6 0.2 0.5 7.7 0.0 0.0 37.2 0.7 124.2 0.1 0.0 0.0 13.7 2.0 2.2 0.0 14.6 1.2 5.1 0.0 0.0 5.2 0.0 0.0 0.0 0.1 334.7 18.8 0.4 0.0 3.9 367.0 1186.6 435.5 0.0 0.0 0.0 1.5 1.9 0.7 0.0 0.0 0.0 2.6 10.4 30.1 1.3 GSTA3 ENSG00000174156 "Glutathione S-transferase alpha 3" Q16772 6 52896639-52909698 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "adrenal gland: 67.3;fallopian tube: 65.4;placenta: 22.7;skin 1: 26.0" "Cell type enhanced" "Detected in some" "Cytotrophoblasts: 194.9;Syncytiotrophoblasts: 515.3;Theca cells: 91.3" "Cancer enhanced" "Detected in some" "endometrial cancer: 1.5;testis cancer: 1.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "SuSa: 1.4" "HPA004342, HPA048934, HPA053817" Approved Supported Cytosol NA NA "Cluster 89: Fibroblasts - ECM organization" "Cluster 12: NES - Nervous system development" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" Cytosol "HPA004342: AB_1078987, HPA048934: AB_2680563, HPA053817: AB_2630367" "unprognostic (7.51e-2)" "unprognostic (7.06e-3)" "unprognostic (3.10e-1)" "unprognostic (5.53e-2)" "unprognostic (4.38e-3)" "unprognostic (2.86e-3)" "unprognostic (1.81e-1)" "unprognostic (1.41e-1)" "unprognostic (1.93e-1)" "unprognostic (9.35e-2)" 0.0 67.3 0.0 0.1 0.1 0.0 1.8 0.0 0.0 1.1 0.5 0.0 0.3 0.8 0.8 0.0 65.4 0.0 0.0 0.0 0.2 0.0 0.0 1.4 0.0 0.1 0.5 0.9 0.1 2.9 0.0 22.7 0.0 0.1 0.0 0.0 0.3 0.2 0.0 26.0 0.4 0.1 0.0 0.0 2.4 11.0 0.3 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.2 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.1 0.5 0.0 0.0 0.3 0.1 0.0 0.0 1.1 0.0 0.0 1.0 0.0 0.9 0.0 0.0 0.4 0.0 0.0 0.0 6.2 0.0 0.0 194.9 0.0 0.0 0.0 0.0 1.3 47.0 0.5 0.5 0.0 0.0 0.0 0.0 7.5 1.1 0.0 0.7 1.3 7.4 0.0 0.4 15.7 0.0 0.0 0.0 2.0 0.0 0.4 2.1 1.5 0.0 24.9 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.4 24.8 0.0 0.0 0.0 0.8 0.5 0.5 0.0 9.8 515.3 0.1 91.3 0.0 0.0 GSTA4 ENSG00000170899 "Glutathione S-transferase alpha 4" O15217 6 52977948-52995304 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 295.7" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 280.0;Granulosa cells: 335.6;Syncytiotrophoblasts: 450.3;Theca cells: 415.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 6 "non-classical monocyte: 20.0" "Lineage enriched" "Detected in many" 6 "monocytes: 20.0" "Cell line enhanced" "Detected in many" "AF22: 95.4;ASC TERT1: 93.1" "Low region specificity" "Detected in all" HPA048934 Approved NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 35: Non-specific - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 40: Granulosa cells - Unknown function" "HPA048934: AB_2680563" "unprognostic (5.13e-3)" "unprognostic (2.75e-1)" "unprognostic (5.04e-2)" "unprognostic (1.38e-1)" "unprognostic (5.24e-2)" "unprognostic (3.63e-3)" "unprognostic (1.81e-1)" "unprognostic (1.63e-2)" "unprognostic (5.05e-3)" "unprognostic (9.26e-2)" "unprognostic (3.31e-3)" "unprognostic (2.29e-2)" "unprognostic (1.34e-2)" "unprognostic (2.21e-1)" "unprognostic (4.07e-3)" "unprognostic (1.53e-1)" "unprognostic (1.13e-1)" 19.2 295.7 51.2 6.9 52.6 1.7 36.0 55.6 61.0 37.0 37.7 19.2 20.4 27.5 61.2 53.4 24.7 22.9 20.4 53.8 55.5 32.1 34.8 38.7 7.3 44.1 43.5 51.9 31.3 74.4 43.1 48.0 45.2 40.7 24.5 31.2 32.8 28.5 35.9 136.0 19.0 26.2 43.0 13.6 37.2 37.3 48.7 9.9 25.0 36.7 21.4 15.6 40.3 53.8 1.3 10.3 95.4 80.3 56.1 93.1 8.9 13.6 33.7 9.4 16.0 15.6 0.3 1.0 9.1 25.8 10.1 3.9 69.7 13.5 11.8 2.3 29.2 3.3 8.2 54.4 39.8 0.0 2.3 80.1 20.6 12.0 10.1 28.5 59.1 14.1 12.9 15.0 31.9 0.0 1.2 0.3 36.4 58.5 17.3 2.4 41.2 18.6 34.3 1.7 42.2 62.1 0.4 9.9 24.9 48.9 2.5 2.8 28.5 10.0 22.6 9.3 11.6 18.4 2.5 0.5 15.2 1.5 11.0 0.0 0.0 0.0 2.6 0.9 2.0 0.8 0.7 1.2 0.9 2.9 0.5 0.7 0.0 3.2 20.0 1.7 0.8 0.9 51.2 52.6 55.6 61.0 53.8 55.5 44.1 43.5 45.2 43.0 48.7 53.8 15.4 51.3 84.3 22.9 2.2 44.9 22.0 79.0 35.3 39.7 26.1 31.2 10.0 15.7 44.4 27.6 0.0 280.0 3.6 5.6 54.8 14.0 1.4 3.5 24.1 20.0 23.9 9.5 63.4 9.0 108.8 40.5 23.0 4.1 5.7 335.6 31.4 21.1 69.8 37.0 88.2 41.8 57.0 2.5 14.6 9.6 41.7 3.5 96.0 13.1 2.8 70.1 4.1 75.9 62.7 10.8 9.6 39.1 0.8 25.8 12.7 47.7 15.6 11.3 19.7 28.5 36.3 4.7 10.5 96.3 135.5 450.3 3.9 415.9 18.0 21.1 GSTA5 ENSG00000182793 "Glutathione S-transferase alpha 5" Q7RTV2 6 52831655-52840843 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Cell type enriched" "Detected in some" 10 "Smooth muscle cells: 23.6" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA004342, HPA048934, HPA053817" Uncertain Approved Cytosol NA NA "Cluster 10: Non-specific - Unknown function" Cytosol "HPA004342: AB_1078987, HPA048934: AB_2680563, HPA053817: AB_2630367" "unprognostic (1.97e-2)" "unprognostic (2.83e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.2 2.2 0.4 0.0 0.0 0.0 23.6 0.4 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.1 GSTK1 GST13 ENSG00000197448 "Glutathione S-transferase kappa 1" Q9Y2Q3 7 143244093-143270854 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 1160.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006311, HPA022904" Supported Supported Peroxisomes NA NA 110000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 8: Non-specific - Mitochondria" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 39: Non-specific - Basic cellular processes" Peroxisomes "HPA006311: AB_1849786, HPA022904: AB_1849787" "prognostic favorable (4.41e-6)" "unprognostic (2.40e-1)" "unprognostic (6.53e-2)" "unprognostic (4.49e-3)" "unprognostic (2.92e-2)" "unprognostic (1.15e-2)" "unprognostic (1.37e-1)" "unprognostic (2.99e-1)" "unprognostic (1.43e-1)" "unprognostic (3.76e-3)" "unprognostic (1.99e-2)" "unprognostic (7.27e-2)" "prognostic favorable (2.10e-6)" "unprognostic (2.66e-2)" "unprognostic (2.94e-1)" "unprognostic (9.13e-2)" "unprognostic (2.15e-2)" 150.9 180.9 77.5 135.9 82.5 187.0 159.1 82.7 89.2 154.5 141.0 217.9 317.2 95.2 110.7 154.0 144.7 140.6 271.7 75.7 82.7 257.2 449.3 125.1 185.0 85.2 84.0 71.1 138.0 308.2 79.7 104.2 85.3 111.4 230.8 26.9 213.0 96.4 238.6 132.6 277.1 106.6 79.8 236.5 163.4 85.1 83.3 96.2 160.1 324.1 183.7 129.5 112.4 88.6 150.7 106.1 14.7 130.1 224.2 319.7 68.8 87.0 148.4 76.3 150.8 64.5 375.2 85.4 120.8 126.7 114.5 222.4 57.5 136.2 66.0 165.0 62.3 69.6 80.9 102.9 154.1 84.7 108.4 290.4 164.3 88.0 62.0 113.1 205.3 109.5 99.3 100.9 207.2 116.2 87.3 152.9 34.7 291.3 158.6 73.9 2.4 169.6 266.1 81.6 59.7 81.4 159.4 256.3 137.4 88.3 123.6 117.0 122.2 41.0 37.7 108.5 75.2 171.0 86.5 20.0 148.5 336.0 86.6 351.1 537.1 210.7 298.5 597.9 289.7 254.5 554.6 386.4 445.2 183.2 281.3 274.6 165.0 188.3 641.7 187.0 800.5 917.1 77.5 82.5 82.7 89.2 75.7 82.7 85.2 84.0 85.3 79.8 83.3 88.6 181.9 70.5 95.6 17.0 134.1 114.2 174.9 244.0 118.4 11.6 181.9 198.2 172.9 211.6 219.5 121.4 12.5 295.3 151.4 301.6 291.6 160.5 561.3 102.7 95.8 117.0 153.6 63.3 25.8 120.3 132.0 96.4 185.5 92.9 145.1 47.4 155.3 322.1 304.2 8.4 28.8 252.8 154.6 288.3 174.1 1160.2 72.7 195.8 151.2 16.9 228.5 85.9 194.7 16.6 14.3 104.5 505.2 50.8 130.0 82.9 670.0 620.2 154.0 15.4 85.5 65.9 121.7 6.9 10.3 166.3 116.4 183.7 250.7 150.7 366.5 218.9 GSTM1 "GST1, H-B, MU" ENSG00000134184 "Glutathione S-transferase mu 1" P09488 1 109687814-109709039 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 479.1;liver: 609.6" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 9.6;Alveolar cells type 2: 6.8;Cardiomyocytes: 6.0;Club cells: 6.7;Hepatocytes: 5.5;Kupffer cells: 7.1" "Cancer enhanced" "Detected in all" "urothelial cancer: 63.1" "Region enriched" "Detected in all" 18 "cerebral cortex: 479.1" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HEL: 87.0;HeLa: 96.1;HHSteC: 78.6;hTEC/SVTERT24-B: 73.0;HUVEC TERT2: 62.4;MOLT-4: 115.4;U-266/84: 64.4" "Low region specificity" "Detected in all" "CAB022669, CAB047357, HPA048652, HPA055972, HPA055973" Approved Approved "Cytokinetic bridge,Cytosol" Yes NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 15: Hepatocytes - Hemostasis" Cytosol "Cytokinetic bridge" "CAB022669: , CAB047357: , HPA048652: AB_2680478, HPA055972: AB_2682992, HPA055973: AB_2682993" "unprognostic (2.22e-2)" "unprognostic (5.35e-2)" "unprognostic (3.87e-3)" "unprognostic (3.20e-1)" "unprognostic (4.95e-2)" "unprognostic (1.03e-1)" "unprognostic (3.56e-2)" "unprognostic (1.81e-1)" "unprognostic (2.41e-1)" "unprognostic (6.55e-2)" "unprognostic (2.34e-1)" "unprognostic (3.45e-1)" "unprognostic (3.17e-2)" "unprognostic (2.12e-1)" "unprognostic (1.36e-1)" "unprognostic (2.18e-1)" "unprognostic (4.72e-3)" 55.5 155.7 26.1 17.4 26.4 9.7 56.9 24.9 479.1 61.5 26.9 39.1 27.9 38.1 69.6 152.3 45.8 29.4 30.5 25.9 25.8 37.3 609.6 28.2 1.8 25.5 26.3 178.4 66.8 48.7 33.5 8.7 26.1 47.0 22.4 10.2 43.8 128.6 69.3 73.5 47.3 64.3 25.0 63.6 59.5 57.0 26.6 33.5 27.7 0.0 17.9 127.0 135.2 25.3 0.3 0.6 0.3 1.3 0.0 0.0 0.5 0.0 0.3 0.2 0.4 1.0 7.0 26.9 0.1 41.6 0.0 1.3 0.1 0.6 0.7 0.1 0.4 87.0 96.1 1.7 78.6 0.0 0.7 0.1 0.1 73.0 0.3 48.1 62.4 50.1 0.0 56.8 2.5 0.0 115.4 0.7 54.6 0.1 0.0 0.4 0.6 11.1 9.0 0.1 5.3 0.7 0.0 0.3 0.5 2.6 1.1 44.5 0.2 35.5 2.0 0.9 0.1 45.1 64.4 3.7 30.7 1.1 2.0 2.2 26.1 32.2 28.8 39.1 31.0 30.8 31.4 28.5 77.8 32.5 33.1 32.6 2.0 30.1 17.4 41.1 38.9 28.5 26.1 26.4 24.9 479.1 25.9 25.8 25.5 26.3 26.1 25.0 26.6 25.3 0.3 9.6 6.8 0.0 0.2 1.8 0.6 2.0 0.0 0.1 2.7 1.9 6.0 2.8 6.7 0.0 0.0 0.0 0.8 0.4 0.0 1.2 0.0 0.9 1.9 0.8 0.0 0.0 0.0 0.0 0.0 1.7 0.0 1.5 2.5 0.0 5.0 5.5 0.1 0.0 0.0 0.3 0.0 7.1 2.2 0.4 3.7 0.5 0.0 0.0 0.7 2.4 0.0 0.0 0.0 0.6 0.1 2.2 0.0 0.1 1.9 0.0 5.1 0.0 0.0 0.3 1.4 0.5 0.4 0.0 1.6 0.0 0.8 0.0 0.2 1.8 GSTM2 GST4 ENSG00000213366 "Glutathione S-transferase mu 2" P28161 1 109668022-109709551 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 61.0;Plasma cells: 28.4;Squamous epithelial cells: 27.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "ASC TERT1: 116.0;HSkMC: 115.6" "Low region specificity" "Detected in all" "CAB040547, HPA055972, HPA055973" Approved Supported Vesicles,Cytosol NA NA 1200000 "Cluster 26: Non-specific - Mitochondria" "Cluster 35: Non-specific - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 59: Non-specific - Transcription" Cytosol Vesicles "CAB040547: , HPA055972: AB_2682992, HPA055973: AB_2682993" "unprognostic (2.51e-3)" "unprognostic (1.28e-1)" "unprognostic (2.04e-2)" "unprognostic (2.57e-2)" "unprognostic (2.20e-1)" "unprognostic (5.04e-2)" "unprognostic (7.31e-2)" "prognostic favorable (9.70e-5)" "unprognostic (1.51e-2)" "unprognostic (7.43e-2)" "unprognostic (1.80e-3)" "unprognostic (2.94e-1)" "unprognostic (1.48e-3)" "unprognostic (1.07e-2)" "unprognostic (1.87e-1)" "unprognostic (2.32e-1)" "unprognostic (2.14e-1)" 73.7 84.4 92.3 11.9 109.9 10.7 81.2 86.7 104.6 165.9 111.5 115.2 26.3 70.6 43.7 61.6 102.7 22.0 99.7 93.5 104.7 86.8 35.6 45.2 14.3 94.3 97.1 240.9 54.5 53.6 113.7 9.3 91.9 159.0 17.7 25.1 55.2 80.7 218.4 88.2 65.5 34.2 93.9 52.6 88.3 41.9 105.2 15.9 97.9 108.4 12.6 108.3 144.5 90.6 0.0 3.5 37.8 38.9 44.0 116.0 7.2 24.5 42.6 22.1 28.0 6.7 0.0 0.7 25.5 61.1 18.0 0.2 3.1 0.2 28.6 1.5 0.8 14.0 0.4 9.3 29.6 1.1 25.2 115.6 1.0 32.7 0.0 58.5 16.1 11.6 4.2 0.7 48.5 0.3 19.5 24.6 6.7 0.7 32.4 23.8 0.1 0.2 6.6 0.5 8.1 18.7 0.0 1.0 13.0 21.7 38.6 7.0 0.2 24.3 1.2 35.3 1.9 11.9 19.0 1.3 36.7 0.5 0.3 1.8 3.8 29.6 3.1 6.3 3.1 8.8 8.8 3.4 23.0 6.2 34.4 15.1 2.2 18.0 4.1 29.8 9.4 10.8 92.3 109.9 86.7 104.6 93.5 104.7 94.3 97.1 91.9 93.9 105.2 90.6 2.0 0.0 4.8 16.0 4.5 4.8 2.4 0.9 20.5 1.5 4.5 4.3 61.0 2.8 11.5 3.7 0.0 0.5 6.1 0.4 0.0 0.2 1.9 2.8 10.3 5.8 0.0 10.9 1.5 0.0 0.2 19.2 14.8 2.7 2.5 4.4 1.8 0.8 1.5 3.3 2.6 1.3 2.0 0.8 2.3 10.4 15.5 3.4 5.4 11.2 0.7 7.2 8.2 12.5 0.7 0.1 0.0 10.5 28.4 0.8 0.4 1.2 9.9 0.3 6.6 5.6 13.6 0.3 0.8 27.0 2.8 0.5 5.1 4.0 0.7 1.6 GSTM3 GST5 ENSG00000134202 "Glutathione S-transferase mu 3" P21266 1 109733932-109741038 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 377.9" "Cell type enhanced" "Detected in all" "Distal tubular cells: 802.2;Early spermatids: 2092.4;Late spermatids: 3843.4;Spermatocytes: 1177.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "eosinophil: 3.4;gdT-cell: 3.1;memory CD4 T-cell: 3.9;memory CD8 T-cell: 2.2;naive CD4 T-cell: 7.8;naive CD8 T-cell: 4.3;T-reg: 1.9" "Group enriched" "Detected in many" 7 "granulocytes: 3.4;T-cells: 7.8" "Cell line enhanced" "Detected in many" "SK-BR-3: 228.4;T-47d: 479.6;WM-115: 186.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "CAB017130, HPA035190, CAB040583, HPA055972" Enhanced Approved Cytosol NA NA 790000 "Cluster 32: T-cells - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 6: T47d - Mammary gland" "Cluster 25: Spermatids - Spermatogenesis" Cytosol "CAB017130: , CAB040583: , HPA035190: AB_10795023, HPA055972: AB_2682992" "unprognostic (2.13e-2)" "unprognostic (2.76e-2)" "unprognostic (1.95e-1)" "unprognostic (5.87e-2)" "unprognostic (1.25e-1)" "unprognostic (7.28e-2)" "unprognostic (3.28e-3)" "unprognostic (1.98e-1)" "prognostic unfavorable (1.89e-4)" "unprognostic (3.45e-1)" "unprognostic (1.51e-1)" "unprognostic (2.30e-1)" "unprognostic (6.16e-3)" "unprognostic (1.38e-2)" "unprognostic (1.21e-2)" "unprognostic (1.90e-2)" "unprognostic (3.48e-2)" 38.7 39.0 56.9 11.0 61.1 3.3 83.5 50.3 69.1 52.7 109.7 45.0 46.8 32.1 243.2 53.6 35.1 47.0 74.8 56.9 63.6 188.1 20.0 23.6 6.2 54.4 54.8 120.4 101.0 41.1 33.7 21.6 55.5 47.5 19.9 21.1 22.6 165.9 65.8 57.2 27.8 58.3 57.5 14.1 76.2 377.9 61.6 13.2 57.9 51.2 7.9 57.1 53.2 58.3 0.2 6.9 49.3 0.1 64.5 39.9 8.5 54.3 9.4 58.2 56.2 21.8 1.9 0.1 30.8 27.8 40.1 2.6 10.0 22.3 80.5 0.3 14.9 50.8 152.1 33.9 69.5 0.0 115.2 40.3 27.0 87.8 0.1 63.5 73.1 61.9 4.7 0.6 26.6 30.0 14.5 1.2 5.3 0.2 93.1 0.4 31.9 2.3 16.3 117.1 86.1 46.0 112.5 228.4 10.5 14.1 479.6 75.3 57.9 0.8 20.9 59.6 36.3 7.7 13.1 0.2 0.6 0.1 186.9 0.3 0.1 3.4 3.1 0.1 0.8 0.3 3.9 2.2 0.1 0.2 7.8 4.3 0.9 0.7 0.1 0.5 1.9 1.5 56.9 61.1 50.3 69.1 56.9 63.6 54.4 54.8 55.5 57.5 61.6 58.3 22.2 6.4 11.5 18.3 7.0 143.5 97.2 104.4 50.1 17.5 196.1 176.8 88.0 50.1 35.9 222.5 6.2 16.3 8.7 17.3 802.2 88.0 2092.4 51.4 40.6 32.9 50.4 33.0 7.5 149.5 9.0 131.6 43.8 93.6 9.5 22.7 58.2 14.2 10.6 15.2 8.0 24.9 28.5 13.9 54.1 3843.4 385.5 15.1 60.5 2.8 3.5 247.5 2.1 14.6 1.7 126.4 32.5 276.1 3.4 53.7 116.9 38.9 5.4 19.2 190.7 23.8 94.4 1177.6 54.4 71.9 107.4 10.3 24.4 121.4 44.1 80.8 GSTM4 ENSG00000168765 "Glutathione S-transferase mu 4" Q03013 1 109656099-109674836 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Lipid metabolism" "Lyase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 149.5" "Cell type enhanced" "Detected in many" "Proximal enterocytes: 382.8;Proximal tubular cells: 109.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 9 "eosinophil: 351.7" "Lineage enriched" "Detected in all" 9 "granulocytes: 351.7" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA048652, HPA055972, HPA055973" Approved Approved "Cytokinetic bridge,Cytosol" Yes NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 8: Non-specific - Mitochondria" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 45: Enterocytes - Digestion" Cytosol "Cytokinetic bridge" "HPA048652: AB_2680478, HPA055972: AB_2682992, HPA055973: AB_2682993" "prognostic favorable (9.96e-5)" "unprognostic (1.96e-3)" "unprognostic (7.49e-2)" "unprognostic (9.92e-3)" "unprognostic (1.48e-1)" "unprognostic (1.08e-2)" "unprognostic (8.47e-2)" "unprognostic (3.48e-2)" "unprognostic (1.20e-1)" "unprognostic (4.76e-2)" "unprognostic (3.73e-1)" "unprognostic (1.44e-1)" "unprognostic (1.46e-1)" "unprognostic (1.92e-2)" "unprognostic (2.20e-1)" "unprognostic (1.41e-1)" "unprognostic (2.47e-2)" 22.3 31.1 19.7 15.3 23.7 5.9 22.5 19.1 23.8 24.5 40.0 45.4 149.5 22.6 24.3 31.3 22.2 17.8 33.5 19.2 19.9 45.9 41.2 14.6 11.8 20.7 20.9 42.9 21.2 57.8 18.6 7.6 20.2 25.8 38.5 12.5 21.2 41.0 92.4 20.6 99.4 25.7 21.1 30.2 28.8 15.1 20.1 9.9 27.7 45.5 15.6 36.8 28.8 20.2 13.5 6.0 10.5 78.9 23.0 35.1 13.4 4.3 34.1 9.8 12.8 43.3 1.5 12.5 16.1 19.1 19.3 13.6 27.1 14.4 6.2 18.9 0.0 27.4 23.5 38.8 37.1 9.5 31.8 22.3 14.0 12.6 0.0 27.5 8.1 31.7 12.8 18.4 6.9 12.7 8.1 41.9 8.2 56.3 31.9 16.9 5.8 18.5 38.8 9.6 7.4 17.6 0.2 68.2 54.9 7.8 18.6 20.1 3.6 11.4 44.0 12.5 6.3 27.0 51.4 1.1 37.1 13.9 32.5 11.9 14.5 351.7 12.2 14.5 7.4 17.0 9.3 14.1 37.8 14.9 8.9 10.7 1.8 12.8 3.6 12.6 14.1 12.6 19.7 23.7 19.1 23.8 19.2 19.9 20.7 20.9 20.2 21.1 20.1 20.2 6.9 9.6 2.7 11.4 9.9 18.1 27.3 17.9 18.8 6.2 14.7 19.0 30.2 21.5 9.5 31.3 0.0 21.0 13.9 53.0 101.8 45.9 3.0 4.5 10.8 8.6 7.2 4.2 3.3 57.7 18.6 22.9 13.3 5.4 21.0 13.3 14.3 35.7 35.6 5.0 3.3 45.9 6.1 17.2 26.0 6.4 30.1 14.9 40.9 2.8 14.8 23.9 17.5 5.0 3.4 35.4 38.6 24.8 13.3 6.7 382.8 109.8 7.5 5.4 32.9 15.3 23.2 7.0 7.3 23.0 15.3 8.8 11.2 12.6 96.7 26.9 GSTM5 ENSG00000134201 "Glutathione S-transferase mu 5" P46439 1 109711780-109775428 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 4 "breast: 929.9" "Group enriched" "Detected in many" 4 "Fibroblasts: 59.0;Leydig cells: 143.5;Muller glia cells: 213.3;Peritubular cells: 127.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 4 "plasmacytoid DC: 3.9" "Lineage enriched" "Detected in single" 4 "dendritic cells: 3.9" "Group enriched" "Detected in some" 5 "fHDF/TERT166: 21.6;HHSteC: 10.3;HSkMC: 10.9" "HPA055972, HPA055973" Approved Uncertain "Cytokinetic bridge,Cytosol" Yes NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 5: Breast - Unknown function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 5: Muller glia cells - Visual perception" Cytosol "Cytokinetic bridge" "HPA055972: AB_2682992, HPA055973: AB_2682993" "unprognostic (1.46e-2)" "unprognostic (8.64e-3)" "unprognostic (5.58e-2)" "unprognostic (1.42e-1)" "unprognostic (5.34e-3)" "unprognostic (8.09e-2)" "unprognostic (9.64e-4)" "unprognostic (1.31e-2)" "unprognostic (1.44e-1)" "unprognostic (9.16e-2)" "unprognostic (3.31e-1)" "unprognostic (1.92e-2)" "unprognostic (1.42e-2)" "unprognostic (3.74e-2)" "unprognostic (4.39e-2)" "unprognostic (3.03e-3)" "unprognostic (1.40e-1)" 21.7 6.4 60.3 4.6 65.3 0.5 929.9 60.4 71.1 72.5 62.9 13.9 2.3 35.1 32.9 11.6 62.0 25.8 17.0 61.4 54.5 5.5 3.9 18.0 5.0 57.2 55.4 213.9 4.7 0.2 9.4 0.8 56.7 27.9 7.8 12.4 7.9 32.6 3.9 12.2 10.3 26.5 60.1 7.7 13.2 11.4 53.5 6.4 9.1 14.0 6.5 27.9 47.6 58.6 0.0 0.0 0.0 0.0 1.7 1.6 0.4 1.3 0.0 0.3 0.2 0.0 0.0 0.1 0.0 21.6 0.0 0.0 0.0 0.0 0.6 0.0 0.0 2.8 0.0 0.0 10.3 0.0 0.0 10.9 0.0 0.0 0.0 0.0 0.7 0.4 0.0 0.0 0.0 0.0 0.1 0.4 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.7 0.1 0.0 0.1 0.0 0.6 0.0 3.9 0.9 0.7 60.3 65.3 60.4 71.1 61.4 54.5 57.2 55.4 56.7 60.1 53.5 58.6 2.5 0.0 0.5 32.3 0.0 6.6 0.9 0.2 0.0 2.0 0.5 0.8 0.9 1.5 0.0 0.0 2.1 0.0 0.3 0.0 0.0 0.0 9.0 0.3 12.3 2.2 0.0 2.1 0.1 0.0 0.1 59.0 1.1 0.3 0.0 0.6 5.7 0.0 0.3 0.0 0.5 0.1 0.0 0.6 9.3 15.1 143.5 0.6 10.6 1.9 0.0 213.3 0.0 2.0 0.3 0.0 0.0 127.2 0.1 0.1 0.1 0.0 0.0 6.8 26.3 2.3 9.4 2.0 1.8 1.0 6.5 0.0 2.8 2.4 0.1 0.6 GSTO1 "GSTTLp28, P28" ENSG00000148834 "Glutathione S-transferase omega 1" P78417 10 104235356-104267459 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Oxidoreductase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 657.7" "Cell type enhanced" "Detected in all" "Hofbauer cells: 676.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "SK-MEL-30: 1106.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037603, HPA037604" Enhanced NA NA 120000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 85: Liver - Metabolism" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 51: Myeloid cells - Hemostasis" "HPA037603: AB_2675574, HPA037604: AB_10672283" "prognostic favorable (6.95e-4)" "unprognostic (9.23e-2)" "unprognostic (1.43e-2)" "unprognostic (6.83e-2)" "unprognostic (7.16e-2)" "prognostic unfavorable (8.83e-4)" "unprognostic (1.38e-2)" "unprognostic (1.84e-1)" "unprognostic (9.23e-3)" "unprognostic (4.57e-2)" "unprognostic (7.65e-2)" "unprognostic (2.13e-1)" "prognostic unfavorable (2.11e-4)" "unprognostic (1.86e-2)" "unprognostic (1.29e-1)" "unprognostic (5.51e-3)" "unprognostic (5.82e-2)" 95.0 145.4 119.1 102.8 123.1 191.6 89.9 121.3 166.7 90.1 118.0 92.7 167.6 72.0 96.2 79.3 75.4 84.8 277.4 117.3 124.8 154.4 657.7 154.7 93.1 121.3 127.1 83.1 80.5 129.7 102.9 113.6 122.7 80.3 94.8 38.2 75.6 89.6 148.4 63.8 165.2 86.9 122.2 107.1 93.3 14.9 128.8 124.8 82.9 122.5 77.4 109.6 82.6 136.4 287.7 194.5 142.9 249.3 201.4 385.1 62.8 358.3 640.7 237.9 257.2 247.2 292.8 254.2 152.8 245.6 296.8 158.8 97.0 329.2 244.5 128.4 233.7 186.6 122.1 542.7 359.7 241.5 294.5 291.5 136.7 346.3 414.5 331.3 464.1 231.2 394.4 153.4 511.4 159.3 188.3 330.0 130.4 308.1 134.8 136.0 94.9 108.1 358.4 185.1 72.1 88.6 117.6 81.0 1106.0 238.2 92.0 192.7 426.6 276.9 143.6 427.3 328.4 2.7 3.3 2.0 517.7 416.2 112.0 842.8 532.4 157.9 133.0 457.0 164.5 148.8 164.6 172.9 429.3 111.9 143.0 144.3 151.8 185.0 369.1 203.0 204.8 632.1 119.1 123.1 121.3 166.7 117.3 124.8 121.3 127.1 122.7 122.2 128.8 136.4 107.4 76.9 72.6 8.8 64.8 93.7 328.2 297.6 51.2 36.9 63.5 105.5 328.2 218.8 113.3 101.2 20.9 394.2 82.0 101.6 332.6 341.0 22.4 68.1 79.6 164.5 103.5 192.8 12.1 248.4 176.6 173.0 49.5 81.7 146.3 107.6 388.0 628.2 676.5 23.5 11.7 163.8 124.1 321.8 223.6 17.3 114.6 484.5 126.3 8.4 277.7 81.2 95.8 8.5 21.8 347.6 150.7 112.8 39.9 169.4 483.2 538.0 114.3 29.8 151.2 85.3 176.1 5.7 5.1 55.8 78.7 111.0 81.4 224.8 196.6 204.9 GSTO2 ENSG00000065621 "Glutathione S-transferase omega 2" Q9H4Y5 10 104268873-104304950 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Oxidoreductase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 35.9" "Cell type enhanced" "Detected in many" "Distal tubular cells: 133.1;Early spermatids: 314.6;Late spermatids: 442.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "BJ hTERT+: 16.9;CAPAN-2: 17.1;hTCEpi: 16.2;hTERT-HME1: 18.3;OE19: 22.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in some" HPA048141 Approved NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 22: Non-specific - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 34: Spermatids - Unknown function" "HPA048141: AB_2680281" "unprognostic (5.77e-2)" "unprognostic (6.69e-2)" "unprognostic (7.15e-2)" "unprognostic (1.80e-1)" "unprognostic (2.48e-1)" "unprognostic (3.11e-2)" "unprognostic (3.12e-1)" "unprognostic (2.15e-1)" "unprognostic (7.42e-2)" "unprognostic (5.28e-2)" "unprognostic (1.44e-1)" "unprognostic (1.02e-1)" "prognostic favorable (7.10e-7)" "unprognostic (4.56e-2)" "unprognostic (3.92e-2)" "unprognostic (1.75e-2)" "unprognostic (3.47e-1)" 0.5 3.5 5.0 0.3 5.7 2.0 5.2 3.4 5.3 4.3 0.4 4.4 2.8 2.2 4.9 11.8 4.3 1.2 0.6 4.4 4.1 14.0 2.8 2.4 0.3 2.2 2.5 5.4 16.7 5.0 14.6 1.0 2.6 8.3 3.1 6.0 7.5 3.2 1.4 14.8 3.5 1.2 1.1 0.5 10.9 35.9 4.3 2.2 7.0 1.3 0.7 3.8 7.5 5.3 10.2 1.4 0.5 0.6 0.6 1.3 1.4 9.6 16.9 4.7 4.9 0.6 17.1 1.6 4.0 0.8 0.5 10.7 0.5 5.3 1.2 1.1 3.2 0.5 3.1 2.4 2.1 0.7 0.7 1.7 16.2 0.3 18.3 1.3 0.8 1.7 1.5 2.9 1.3 12.3 0.1 0.5 1.7 22.1 1.1 0.5 0.7 0.3 4.6 6.5 0.6 1.1 3.3 2.4 2.9 0.8 12.6 0.3 2.4 1.5 5.1 0.6 0.5 2.8 6.4 0.4 1.5 0.8 0.5 0.2 0.1 0.7 0.5 0.2 0.3 0.3 0.5 0.3 0.0 0.5 0.7 0.4 1.7 1.0 0.1 0.3 1.2 0.2 5.0 5.7 3.4 5.3 4.4 4.1 2.2 2.5 2.6 1.1 4.3 5.3 3.6 3.2 21.0 13.1 1.3 34.2 62.1 94.5 50.1 19.0 61.7 78.2 3.0 21.5 46.4 40.5 16.7 14.4 3.8 12.8 133.1 30.6 314.6 26.9 7.6 5.4 54.2 3.6 33.9 63.3 9.9 4.7 31.6 37.6 2.5 3.3 15.7 3.6 1.8 0.0 28.7 34.0 50.8 1.6 3.7 442.8 2.8 2.7 17.8 1.9 2.1 11.1 1.0 24.1 20.1 31.6 29.1 9.8 0.9 25.6 27.1 43.8 31.2 23.0 6.6 3.1 7.4 22.0 8.9 46.0 47.3 6.7 4.3 11.6 40.7 58.0 GSTP1 "FAEES3, GST3, GSTP" ENSG00000084207 "Glutathione S-transferase pi 1" P09211 11 67583742-67586656 "Cancer-related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "esophagus: 2087.9" "Cell type enhanced" "Detected in all" "Squamous epithelial cells: 4033.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "hTCEpi: 4998.3;OE19: 7810.3" "Low region specificity" "Detected in all" "HPA019779, HPA019869" Enhanced Supported Mitochondria,Cytosol No No 69000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 21: OE19 - Mitochondria" "Cluster 61: Squamous epithelial cells - Keratinization" "Mitochondria, Cytosol" "HPA019779: AB_1849799, HPA019869: AB_1849801" "unprognostic (9.81e-2)" "unprognostic (6.52e-2)" "unprognostic (7.24e-2)" "unprognostic (2.72e-2)" "unprognostic (1.06e-2)" "unprognostic (1.30e-3)" "unprognostic (3.27e-1)" "unprognostic (4.98e-2)" "unprognostic (1.28e-1)" "unprognostic (5.16e-3)" "unprognostic (2.14e-3)" "unprognostic (9.37e-2)" "unprognostic (5.72e-2)" "unprognostic (7.78e-2)" "unprognostic (2.23e-1)" "unprognostic (6.72e-3)" "unprognostic (1.48e-1)" 290.5 276.2 346.8 232.1 370.3 601.3 288.7 358.9 425.7 641.9 695.8 329.6 394.6 331.9 280.3 2087.9 647.5 435.8 367.2 341.4 381.9 567.7 45.1 468.3 321.8 375.7 379.2 306.9 340.9 737.4 320.2 326.9 378.5 291.7 197.1 137.9 541.2 780.4 355.0 731.4 321.7 214.2 367.0 257.2 535.5 45.8 378.1 296.9 579.0 312.5 380.8 526.5 946.2 377.7 1202.5 1599.4 763.7 1198.9 577.8 645.2 705.3 511.3 678.1 761.2 589.3 2956.3 1225.0 3.3 1144.7 813.5 683.7 1707.8 2073.9 2248.5 214.4 848.0 765.3 59.9 1107.6 0.5 852.2 400.3 667.6 807.2 4998.3 609.9 583.3 560.9 1160.2 847.2 1318.2 321.8 605.7 4.3 918.2 1100.6 1475.2 7810.3 681.3 844.8 129.6 3.8 1236.8 3.6 260.6 754.3 719.1 230.9 2394.0 598.2 3.6 656.3 634.5 351.6 883.8 740.6 378.6 200.0 1353.9 447.1 400.0 652.4 747.8 56.0 3145.4 246.6 720.0 2470.8 271.9 509.2 322.4 597.7 3582.7 476.3 267.8 466.5 130.5 1443.8 1608.5 1435.1 363.3 3948.4 346.8 370.3 358.9 425.7 341.4 381.9 375.7 379.2 378.5 367.0 378.1 377.7 466.7 1153.8 872.3 25.5 296.8 865.6 1914.8 3813.8 767.2 170.0 628.7 838.3 297.3 987.9 2763.5 1230.4 33.3 2116.8 372.4 655.0 1805.9 1811.9 4.9 1381.0 589.0 431.4 368.2 166.3 6.8 1444.4 1703.9 710.5 781.9 1020.9 269.9 795.0 382.3 10.5 861.2 70.7 10.1 992.4 1930.7 597.9 1090.3 25.5 572.3 703.5 1531.5 27.2 2166.5 558.5 459.3 17.6 38.4 1412.1 948.9 400.2 591.6 2266.2 844.4 3495.5 3715.4 274.4 361.6 401.3 941.7 4.8 54.9 4033.7 1061.7 1645.5 342.5 527.8 1118.5 3418.6 GSTT2B GSTT2P ENSG00000133433 "Glutathione S-transferase theta 2B" P0CG30 22 23957414-23961195 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "adrenal gland: 81.8;breast: 307.9" "Cell type enhanced" "Detected in many" "Distal tubular cells: 29.4;Hepatocytes: 27.6;Muller glia cells: 20.9;Peritubular cells: 28.6;Skeletal myocytes: 26.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AN3-CA: 57.0;HHSteC: 81.9;SK-MEL-30: 60.3;T-47d: 64.8" HPA000750 Uncertain Supported Nucleoplasm,Cytosol No No "Cluster 82: Adipose tissue - ECM organization" "Cluster 6: T47d - Mammary gland" "Cluster 33: Fibroblasts - ECM organization" Cytosol Nucleoplasm "HPA000750: AB_1849804" "prognostic favorable (5.06e-4)" "unprognostic (5.14e-2)" "unprognostic (1.90e-1)" "unprognostic (4.51e-2)" "unprognostic (7.13e-2)" "unprognostic (8.41e-3)" "unprognostic (2.58e-1)" "unprognostic (7.99e-2)" "unprognostic (1.15e-1)" "unprognostic (1.92e-1)" "unprognostic (1.76e-2)" "unprognostic (4.11e-1)" "unprognostic (1.18e-2)" "unprognostic (2.04e-1)" "unprognostic (1.07e-1)" "unprognostic (1.48e-2)" "unprognostic (2.19e-3)" 12.3 81.8 21.6 4.3 21.5 0.0 307.9 21.4 27.0 16.6 19.5 17.2 1.4 15.5 12.0 24.7 16.1 5.5 23.9 20.8 22.7 15.2 39.5 18.5 1.8 22.2 22.2 22.6 26.1 6.4 26.0 4.4 22.2 40.6 1.9 3.8 12.5 10.4 16.4 47.8 8.3 11.8 21.0 10.2 23.8 5.5 24.3 1.8 18.6 41.0 1.6 12.1 14.0 21.1 17.0 0.8 0.0 57.0 1.0 1.1 2.4 8.0 4.7 11.5 11.9 24.8 0.2 0.0 12.9 20.2 29.7 24.5 0.0 25.5 5.2 0.0 2.2 0.9 33.6 4.0 81.9 0.1 9.1 33.4 4.0 33.2 6.7 32.6 9.6 0.0 0.0 0.0 6.9 0.3 0.0 0.0 0.2 0.9 12.5 0.0 42.4 0.1 26.0 0.0 1.1 23.8 8.2 0.2 60.3 0.2 64.8 0.9 32.0 9.9 6.5 1.3 6.4 0.0 0.0 0.1 6.1 0.0 23.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 21.6 21.5 21.4 27.0 20.8 22.7 22.2 22.2 22.2 21.0 24.3 21.1 8.1 3.2 3.6 1.3 0.9 0.0 8.6 0.0 2.8 3.9 9.4 17.9 0.2 7.2 1.3 0.0 0.0 1.6 0.1 0.0 29.4 7.9 0.6 1.3 11.8 7.1 1.2 5.3 2.4 9.1 3.5 7.6 1.1 2.9 1.3 2.2 18.5 27.6 10.5 0.0 2.1 0.4 0.0 3.8 0.0 1.5 9.9 1.5 0.0 0.0 3.2 20.9 0.0 2.0 0.7 4.2 0.0 28.6 0.7 7.9 0.0 5.7 0.0 2.8 6.6 26.7 9.6 0.4 0.7 0.9 0.0 1.8 0.2 0.4 0.1 3.8 GSTT4 "GSTTP1, HS322B1A" ENSG00000276950 "Glutathione S-transferase theta 4" A0A1W2PR19 22 23998401-24005453 "Enzymes, Predicted intracellular proteins" Transferase "Evidence at transcript level" "Evidence at transcript level" "No human protein/transcript evidence" "Evidence at transcript level" "Tissue enriched" "Detected in single" 24 "testis: 2.4" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 78: Testis - Spermatogenesis" "unprognostic (5.66e-2)" "unprognostic (1.77e-2)" "unprognostic (6.83e-4)" "unprognostic (4.36e-1)" "unprognostic (5.47e-1)" "unprognostic (2.23e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 GSTZ1 "GSTZ1-1, MAAI, MAI" ENSG00000100577 "Glutathione S-transferase zeta 1" O43708 14 77320996-77331597 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Phenylalanine catabolism, Tyrosine catabolism" "Isomerase, Multifunctional enzyme, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 5 "liver: 263.1" "Cell type enhanced" "Detected in many" "Hepatocytes: 373.2;Late spermatids: 398.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "MCF7: 182.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA004701 Approved Approved Nucleoplasm,Cytosol NA NA 340000 "Cluster 18: Basophils - Vesicular transport" "Cluster 62: Liver - Hemostasis" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 2: Hepatocytes - Metabolism" Cytosol Nucleoplasm "HPA004701: AB_1078990" "prognostic favorable (4.93e-4)" "unprognostic (1.08e-1)" "unprognostic (2.56e-1)" "unprognostic (2.16e-3)" "unprognostic (4.55e-1)" "unprognostic (3.03e-2)" "unprognostic (8.03e-3)" "unprognostic (1.98e-1)" "unprognostic (2.18e-1)" "prognostic favorable (3.73e-4)" "unprognostic (7.90e-2)" "unprognostic (1.73e-1)" "prognostic favorable (1.12e-7)" "unprognostic (1.00e-1)" "unprognostic (1.11e-1)" "unprognostic (4.12e-1)" "unprognostic (4.92e-2)" 13.9 34.7 11.1 9.7 12.5 9.3 23.2 13.2 16.3 12.7 10.5 21.9 22.5 10.8 22.1 26.9 14.9 11.9 14.3 10.5 12.3 24.5 263.1 7.8 13.5 12.6 11.7 6.5 20.1 26.4 13.3 11.2 12.8 21.1 21.7 5.1 24.1 9.6 47.4 22.1 15.6 7.9 12.3 12.1 18.9 57.8 11.9 14.0 19.5 37.3 17.4 11.9 13.8 14.0 18.8 39.0 27.6 19.9 17.1 23.9 45.8 11.4 11.9 21.6 30.9 13.0 45.2 43.5 14.9 13.6 13.4 24.1 18.9 22.5 20.7 23.2 21.0 20.8 13.3 26.9 26.3 7.8 15.8 22.1 24.0 12.4 20.8 12.0 18.6 24.7 17.5 37.0 14.5 182.1 12.2 16.4 8.2 64.1 30.3 20.2 29.5 34.2 32.5 24.0 30.2 26.2 26.0 49.1 35.6 15.5 81.2 11.1 13.8 17.0 52.5 18.9 8.6 28.2 32.7 35.2 41.9 11.3 20.8 13.4 15.5 9.9 2.6 22.2 2.4 8.2 4.6 3.7 20.7 10.4 3.9 3.1 1.6 5.1 20.1 15.0 7.9 7.4 11.1 12.5 13.2 16.3 10.5 12.3 12.6 11.7 12.8 12.3 11.9 14.0 6.1 6.4 9.6 6.5 13.5 13.4 19.8 26.2 15.9 7.3 36.1 34.2 13.0 47.1 19.0 9.2 4.2 91.4 7.5 34.9 46.9 45.0 125.8 19.4 15.6 11.1 28.8 30.3 2.9 68.0 62.5 15.0 33.1 27.0 3.8 25.7 15.4 373.2 44.6 16.8 3.3 45.7 20.3 38.1 10.9 398.1 11.8 19.0 17.8 3.7 30.4 26.4 4.1 2.0 9.2 41.8 37.4 6.0 13.2 19.8 72.9 77.8 15.0 11.9 0.0 12.3 13.2 51.3 29.4 38.0 14.1 76.2 6.7 55.8 50.3 30.3 GTF2B TFIIB ENSG00000137947 "General transcription factor IIB" Q00403 1 88852633-88891944 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction, Transcription, Transcription regulation" "Acyltransferase, DNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA061626 Supported Supported "Nucleoplasm,Nuclear bodies" No No "Cluster 5: Granulocytes - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" "Nucleoplasm, Nuclear bodies" "HPA061626: AB_2684570" "prognostic favorable (4.81e-4)" "unprognostic (5.21e-2)" "unprognostic (3.94e-3)" "unprognostic (1.27e-1)" "unprognostic (1.66e-1)" "unprognostic (2.43e-1)" "unprognostic (1.08e-2)" "unprognostic (2.65e-2)" "unprognostic (4.37e-3)" "unprognostic (3.37e-1)" "unprognostic (1.37e-2)" "unprognostic (3.13e-1)" "unprognostic (1.42e-2)" "unprognostic (1.10e-2)" "unprognostic (1.40e-1)" "unprognostic (4.06e-3)" "unprognostic (3.74e-2)" 25.3 26.4 14.8 18.8 15.7 62.2 28.3 16.4 24.0 22.9 17.7 22.6 17.9 21.8 30.3 26.3 22.7 23.8 15.7 15.5 16.5 22.9 32.6 22.0 28.9 15.5 15.9 26.3 23.3 22.7 20.3 25.2 15.7 18.1 23.1 17.9 22.9 16.3 23.1 28.3 23.9 20.7 16.2 28.7 23.0 16.3 15.1 40.2 21.2 18.5 31.3 31.5 23.7 17.0 40.0 13.6 34.6 18.8 49.8 34.4 42.9 32.1 39.4 44.1 46.4 17.9 24.3 45.5 37.8 28.0 53.3 22.0 36.8 32.1 38.3 42.8 34.3 48.6 21.2 32.1 31.9 56.8 28.7 30.0 32.1 38.2 21.7 33.4 25.1 41.1 43.1 33.6 47.0 12.6 54.9 46.7 28.8 35.4 29.3 34.4 46.8 34.2 47.0 47.2 26.7 22.4 28.5 35.4 57.8 30.7 15.9 51.1 22.3 19.2 24.0 35.0 38.8 35.1 29.9 62.6 12.8 48.8 16.7 91.2 49.3 82.1 45.9 57.1 53.2 57.8 52.1 50.5 62.5 48.2 62.9 53.9 99.7 54.9 60.4 40.5 70.1 50.9 14.8 15.7 16.4 24.0 15.5 16.5 15.5 15.9 15.7 16.2 15.1 17.0 106.6 6.4 29.7 13.7 114.9 46.3 75.4 63.3 58.6 14.6 39.7 104.9 12.3 21.5 45.6 11.0 2.1 74.0 122.3 39.1 39.2 49.2 22.9 53.9 28.4 30.3 20.3 51.1 22.7 38.6 60.0 53.0 41.8 29.8 48.9 30.2 16.8 17.6 40.5 18.5 21.4 30.5 52.9 32.3 42.5 7.9 36.4 93.4 28.4 22.5 40.3 30.7 33.0 18.1 25.2 49.9 70.5 29.3 74.3 27.8 26.9 47.4 55.2 18.5 13.1 86.6 65.0 24.2 29.0 40.1 50.0 150.1 122.8 34.5 22.7 79.4 GTF3C4 "KAT12, TFIIIC90" ENSG00000125484 "General transcription factor IIIC subunit 4" Q9UKN8 9 132670035-132694953 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transcription "Acyltransferase, DNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA069369 Supported Nucleoplasm,Mitochondria No No "Cluster 40: NK-cells - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm Mitochondria "HPA069369: AB_2686130" "unprognostic (7.02e-2)" "unprognostic (9.01e-2)" "unprognostic (1.31e-1)" "unprognostic (4.10e-2)" "unprognostic (8.20e-2)" "unprognostic (2.78e-1)" "unprognostic (3.71e-3)" "unprognostic (1.69e-2)" "unprognostic (1.58e-1)" "unprognostic (1.76e-1)" "unprognostic (4.77e-1)" "unprognostic (1.92e-2)" "prognostic favorable (2.99e-4)" "unprognostic (1.65e-1)" "unprognostic (1.23e-1)" "unprognostic (2.35e-1)" "unprognostic (1.54e-2)" 4.9 4.4 4.3 4.6 5.0 6.9 8.4 9.2 4.3 7.3 3.6 5.3 3.9 6.6 5.5 6.7 6.6 5.2 5.8 4.5 5.2 6.0 5.3 5.7 5.0 3.4 4.8 10.3 6.1 9.4 3.2 6.4 3.7 6.2 5.4 5.5 7.3 5.7 5.8 9.8 3.6 6.2 3.6 4.5 5.8 8.3 5.6 8.1 9.5 8.0 6.6 5.0 3.8 3.8 15.2 21.7 25.8 22.5 12.3 14.4 20.0 15.1 18.4 19.6 14.4 25.4 10.9 22.7 9.8 18.6 18.1 33.8 39.8 23.6 21.1 15.4 19.1 19.0 28.9 10.8 12.8 28.6 12.4 11.4 17.6 20.4 26.1 11.6 16.8 15.1 32.7 11.4 14.0 24.6 17.8 13.3 33.1 22.2 21.4 17.6 31.1 20.6 14.3 12.5 36.3 24.6 25.9 25.8 15.9 15.8 35.4 12.1 17.8 32.9 18.7 15.1 21.6 4.9 12.3 25.1 13.5 17.8 20.7 0.0 0.3 0.2 0.5 0.3 0.4 0.5 0.4 0.6 0.2 0.4 0.5 0.5 0.3 0.5 0.2 0.5 0.4 0.2 4.3 5.0 9.2 4.3 4.5 5.2 3.4 4.8 3.7 3.6 5.6 3.8 9.9 19.2 11.5 2.3 7.8 30.7 6.9 6.9 21.6 15.5 19.1 14.7 14.6 1.5 6.7 3.7 14.6 7.5 9.0 6.6 7.9 8.3 6.5 21.5 26.2 11.6 13.1 8.2 3.2 6.3 7.5 13.0 8.6 17.7 1.3 17.1 10.0 8.6 6.3 20.2 3.1 8.1 10.2 7.6 9.3 3.7 19.0 6.3 3.6 1.9 7.1 11.9 7.2 1.0 2.1 5.8 7.0 19.2 10.7 11.6 3.8 6.6 16.2 16.9 0.0 18.8 10.9 16.7 13.8 22.1 40.1 6.4 8.8 18.2 9.0 6.4 GUK1 ENSG00000143774 "Guanylate kinase 1" Q16774 1 228139962-228148984 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028118, HPA048587, HPA068324" Approved Uncertain Nucleoplasm,Cytosol NA NA 240000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 35: Non-specific - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 16: Pancreatic endocrine cells - Mixed function" Nucleoplasm Cytosol "HPA028118: AB_2756308, HPA048587: AB_2680453, HPA068324: " "unprognostic (9.15e-2)" "unprognostic (2.63e-2)" "unprognostic (3.60e-3)" "unprognostic (7.91e-2)" "unprognostic (8.54e-3)" "unprognostic (1.24e-1)" "unprognostic (3.55e-3)" "unprognostic (2.05e-1)" "unprognostic (3.47e-1)" "unprognostic (7.32e-2)" "unprognostic (3.38e-2)" "unprognostic (5.28e-2)" "prognostic unfavorable (8.85e-5)" "unprognostic (2.91e-1)" "unprognostic (5.41e-1)" "unprognostic (2.39e-2)" "unprognostic (6.12e-2)" 226.7 198.9 291.7 93.9 277.9 251.9 213.3 255.3 465.2 187.1 274.1 196.5 113.8 169.2 48.6 333.8 161.8 116.3 240.0 302.8 257.9 230.6 318.1 222.8 124.5 263.1 263.0 146.9 208.9 72.0 165.7 78.9 261.8 161.3 31.5 110.8 191.0 71.6 149.0 285.7 155.0 53.6 266.3 179.4 202.0 107.3 281.3 97.1 151.3 61.8 39.2 188.6 202.4 289.4 356.1 122.4 53.0 164.5 155.6 186.6 264.3 230.8 116.5 130.8 102.8 70.6 239.1 133.4 266.5 151.4 110.0 230.3 45.7 252.0 14.0 203.7 357.1 79.3 292.9 156.3 282.8 90.5 133.0 260.0 150.6 91.9 73.3 94.2 179.2 279.9 219.5 205.1 109.5 295.2 411.4 194.3 166.8 172.6 522.9 155.3 99.9 354.9 125.2 164.1 173.7 311.3 148.7 250.2 309.7 13.5 185.2 191.7 318.5 237.7 157.4 353.4 387.5 186.8 221.9 151.6 300.3 146.2 246.0 379.0 323.8 663.9 420.6 363.0 406.5 265.0 346.8 454.1 279.7 230.8 256.5 323.4 420.1 339.5 390.9 567.3 394.6 571.4 291.7 277.9 255.3 465.2 302.8 257.9 263.1 263.0 261.8 266.3 281.3 289.4 503.7 60.9 87.2 35.3 199.9 660.0 271.5 643.5 215.7 195.5 425.9 448.7 130.8 195.9 312.2 237.3 717.2 241.6 351.2 655.8 694.6 510.9 134.0 212.5 272.0 451.4 269.6 866.9 50.2 685.5 417.9 276.9 189.1 304.2 182.6 162.5 365.5 353.4 407.5 109.4 33.5 426.5 384.5 291.7 557.0 609.3 233.6 265.6 519.4 22.5 355.5 411.0 398.6 16.1 58.6 975.0 718.8 243.8 365.6 571.5 857.7 801.1 231.6 570.9 249.8 158.2 378.6 89.8 100.3 448.6 719.7 262.4 326.7 226.3 331.5 612.2 GXYLT1 "FLJ43151, GLT8D3" ENSG00000151233 "Glucoside xylosyltransferase 1" Q4G148 12 42081845-42144874 "Enzymes, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "Intracellular and membrane" NA NA 3200000 "Cluster 52: Eosinophils - Transcription" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 32: U-937 - Innate immune response" "Cluster 40: Granulosa cells - Unknown function" "unprognostic (1.09e-2)" "unprognostic (1.16e-1)" "unprognostic (1.53e-1)" "unprognostic (5.07e-1)" "unprognostic (1.22e-1)" "unprognostic (9.89e-2)" "unprognostic (5.22e-3)" "unprognostic (1.77e-2)" "unprognostic (4.42e-3)" "unprognostic (1.46e-2)" "unprognostic (1.64e-2)" "unprognostic (3.20e-1)" "unprognostic (1.92e-2)" "unprognostic (8.16e-2)" "unprognostic (2.93e-1)" "unprognostic (3.96e-2)" "prognostic favorable (3.91e-4)" 5.8 4.8 4.0 5.9 4.3 7.5 4.9 4.6 3.4 4.0 4.2 4.1 4.0 3.9 3.7 3.2 4.5 4.0 3.0 3.4 5.7 6.4 12.2 5.5 5.2 5.0 4.6 5.5 4.2 6.0 3.6 11.1 4.7 4.1 4.9 6.1 3.5 3.3 2.4 4.2 5.6 3.7 5.0 6.7 4.6 9.5 4.5 6.8 8.9 3.9 4.6 4.6 3.4 4.9 12.9 10.8 12.2 11.9 8.5 22.1 45.6 28.4 19.0 20.7 20.9 25.1 25.9 11.2 21.7 15.8 14.9 6.0 20.6 9.2 38.1 18.7 23.2 18.4 9.1 20.5 13.4 20.1 16.9 17.1 7.8 31.6 13.9 12.3 27.7 12.6 11.8 19.3 26.7 8.9 13.0 12.2 14.8 4.9 10.2 6.1 24.6 10.0 12.5 19.1 6.2 10.5 20.2 11.4 16.8 22.6 23.4 15.6 23.9 14.7 49.8 8.7 18.1 25.2 30.4 14.1 19.9 53.8 9.2 0.1 0.6 1.8 0.4 1.2 0.2 0.4 0.6 0.5 1.0 0.4 0.5 0.5 0.4 0.9 1.5 0.2 0.7 0.3 4.0 4.3 4.6 3.4 3.4 5.7 5.0 4.6 4.7 5.0 4.5 4.9 22.1 16.0 15.0 10.1 21.5 3.2 14.3 7.9 8.6 9.0 13.3 8.6 7.4 7.2 8.8 35.0 8.4 42.7 34.2 10.5 1.9 9.5 1.6 7.2 11.9 16.4 3.0 8.0 14.3 10.4 39.8 15.7 6.6 10.7 19.1 57.6 24.3 27.8 13.8 15.2 16.1 9.5 6.1 16.2 7.4 3.4 11.8 13.2 5.4 25.3 20.5 10.3 15.5 16.6 17.8 8.9 12.5 7.5 21.5 14.5 12.3 3.9 12.1 15.5 13.1 13.3 11.7 25.2 33.4 11.0 4.4 45.6 22.2 13.9 9.1 12.7 GXYLT2 GLT8D4 ENSG00000172986 "Glucoside xylosyltransferase 2" A0PJZ3 3 72888046-72998138 "Enzymes, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Early spermatids: 47.9;Endometrial stromal cells: 45.4;Fibroblasts: 23.0;Late spermatids: 27.1;Oligodendrocytes: 61.3;Skeletal myocytes: 40.0;Theca cells: 22.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "GAMG: 22.3;JURKAT: 22.1;MOLT-4: 36.5" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" HPA068429 Uncertain Approved "Nucleoplasm,Cytokinetic bridge,Midbody ring" Yes No "Cluster 35: T-regs - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 50: Fibroblasts - ECM organization" Nucleoplasm "Cytokinetic bridge, Midbody ring" "HPA068429: AB_2685988" "unprognostic (9.43e-2)" "unprognostic (8.87e-3)" "unprognostic (1.90e-1)" "unprognostic (4.77e-2)" "unprognostic (3.33e-2)" "unprognostic (7.04e-2)" "unprognostic (4.79e-3)" "unprognostic (5.29e-2)" "unprognostic (5.25e-2)" "unprognostic (5.10e-2)" "unprognostic (2.00e-1)" "unprognostic (7.33e-2)" "prognostic unfavorable (1.46e-7)" "unprognostic (3.22e-3)" "unprognostic (4.70e-1)" "unprognostic (2.51e-1)" "prognostic unfavorable (2.42e-5)" 6.0 3.8 2.6 5.2 5.3 1.8 4.0 4.3 3.2 5.7 2.6 3.7 0.6 5.6 2.5 3.2 5.1 10.1 13.6 2.0 2.4 0.9 0.3 3.8 1.5 6.2 5.8 16.5 4.2 2.4 1.9 4.0 4.1 3.3 2.0 0.4 5.3 4.0 0.8 1.7 1.2 5.5 5.3 0.7 1.3 5.8 4.6 6.7 8.8 1.5 1.0 5.7 3.6 6.9 0.2 1.8 0.1 11.2 9.9 19.3 1.7 1.8 4.2 4.0 9.8 0.5 1.2 0.0 3.1 4.9 22.3 0.1 1.0 2.2 3.8 0.0 1.3 0.0 7.2 12.4 12.6 4.9 0.0 18.8 1.1 9.7 1.6 6.0 0.0 22.1 5.8 0.1 2.4 2.7 36.5 0.1 6.6 0.1 2.2 0.2 9.5 0.0 1.3 1.7 1.1 5.0 9.8 0.5 1.3 2.0 3.7 1.5 0.1 4.3 13.5 13.3 6.5 1.0 0.1 0.2 11.1 2.3 7.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.6 0.3 0.0 2.6 5.3 4.3 3.2 2.0 2.4 6.2 5.8 4.1 5.3 4.6 6.9 1.6 3.2 2.6 7.2 0.1 1.9 1.9 5.3 0.0 0.6 1.5 7.6 14.6 2.8 2.3 0.0 0.0 0.2 1.5 1.4 0.0 0.1 47.9 5.7 45.4 0.6 3.5 0.0 8.3 1.1 0.3 23.0 0.0 7.5 0.0 8.0 0.7 0.0 0.4 0.0 9.0 2.9 0.0 0.0 4.0 27.1 8.1 0.5 0.0 12.2 0.0 2.5 0.0 3.0 61.3 0.8 0.4 7.2 0.0 2.0 0.6 0.5 2.1 0.4 0.0 40.0 3.9 2.5 4.2 0.2 0.4 0.8 0.4 22.9 1.6 0.4 GYG1 GYG ENSG00000163754 "Glycogenin 1" P46976 3 148991408-149031775 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Glycogen biosynthesis" Transferase "Disease variant, Glycogen storage disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 560.0;tongue: 357.6" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 229.8;Early spermatids: 251.2;Late spermatids: 368.8;Spermatocytes: 296.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030497, HPA073229" Supported Approved Vesicles NA NA 30000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 66: Spermatocytes - Spermatogenesis" Vesicles "HPA030497: AB_10602326, HPA073229: " "unprognostic (2.68e-2)" "unprognostic (6.31e-3)" "unprognostic (3.21e-1)" "unprognostic (1.81e-1)" "unprognostic (6.19e-2)" "unprognostic (1.49e-2)" "prognostic unfavorable (6.15e-5)" "unprognostic (2.55e-2)" "unprognostic (2.71e-1)" "unprognostic (1.10e-1)" "unprognostic (7.75e-3)" "unprognostic (1.29e-1)" "unprognostic (3.56e-2)" "unprognostic (1.27e-2)" "unprognostic (1.96e-1)" "unprognostic (1.05e-1)" "unprognostic (4.79e-2)" 40.3 31.1 30.1 31.3 32.2 219.8 33.8 33.1 39.4 36.5 28.7 152.2 16.7 64.1 38.7 53.6 52.6 23.9 117.8 29.9 44.0 29.0 18.6 41.1 24.8 37.0 39.7 43.8 42.7 25.2 31.5 23.0 39.0 47.3 25.6 34.3 39.7 64.4 560.0 21.2 37.7 68.1 35.9 59.2 50.7 115.1 33.6 18.0 21.1 357.6 23.0 86.1 30.8 38.3 62.7 39.8 29.0 32.6 78.5 81.7 39.5 90.2 74.4 128.3 119.2 52.3 62.2 0.1 43.5 105.1 68.4 18.8 76.7 39.8 128.6 21.1 33.3 47.6 16.7 59.9 70.7 49.1 68.8 45.1 63.8 42.7 53.3 66.8 74.7 30.7 29.8 109.8 74.7 110.3 9.6 38.9 34.9 48.3 32.2 26.7 43.8 89.3 35.7 57.6 23.7 11.3 47.6 64.6 54.4 27.3 64.4 51.4 62.9 65.4 19.4 47.4 66.9 98.7 59.1 44.4 55.1 74.3 21.7 22.7 58.1 42.4 39.4 59.6 73.1 15.9 25.7 41.3 64.0 14.0 13.8 23.5 27.0 44.3 67.9 25.3 39.4 50.1 30.1 32.2 33.1 39.4 29.9 44.0 37.0 39.7 39.0 35.9 33.6 38.3 27.7 12.8 11.1 16.3 28.3 12.1 22.4 27.7 12.5 9.4 22.5 17.1 229.8 15.7 21.9 33.1 18.8 36.5 50.4 9.9 27.4 43.4 251.2 7.9 15.2 32.6 14.4 12.2 9.8 77.6 47.2 45.0 17.3 9.5 18.3 19.7 45.3 13.5 95.3 6.7 11.3 19.0 26.4 87.1 26.3 368.8 53.1 56.2 40.9 6.5 56.2 132.1 36.0 11.6 5.4 31.6 14.3 76.8 104.1 45.9 15.0 17.3 16.1 7.0 65.7 35.8 50.3 296.7 52.2 23.1 14.9 29.3 61.2 33.8 15.2 19.6 GYG2 GN-2 ENSG00000056998 "Glycogenin 2" O15488 X 2828822-2882820 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycogen biosynthesis" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 4 "adipose tissue: 156.3" "Cell type enhanced" "Detected in many" "Astrocytes: 10.7;Enteroendocrine cells: 20.4;Granulosa cells: 10.2;Hepatocytes: 20.2" "Cancer enhanced" "Detected in all" "melanoma: 42.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 39.1;CACO-2: 30.4;Hep G2: 32.6;NTERA-2: 38.4;SK-MEL-30: 87.6;SuSa: 59.0" "Low region specificity" "Detected in all" "HPA005495, HPA064686" Enhanced Approved Nucleoplasm,Nucleoli,Cytosol No No "Cluster 57: Non-specific - Angiogenesis" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 40: Granulosa cells - Unknown function" "Nucleoli, Cytosol" Nucleoplasm "HPA005495: AB_1079035, HPA064686: AB_2685323" "unprognostic (4.45e-2)" "unprognostic (4.21e-2)" "unprognostic (6.41e-3)" "unprognostic (8.50e-2)" "unprognostic (2.07e-3)" "unprognostic (5.16e-1)" "unprognostic (1.74e-2)" "unprognostic (1.18e-1)" "unprognostic (7.43e-3)" "unprognostic (6.74e-2)" "prognostic favorable (3.01e-5)" "unprognostic (9.76e-2)" "unprognostic (6.10e-5)" "unprognostic (1.78e-1)" "unprognostic (5.05e-3)" "unprognostic (5.41e-2)" "unprognostic (6.60e-2)" 156.3 2.2 10.3 1.9 10.8 0.2 38.9 18.4 8.8 3.0 8.5 3.9 1.5 6.6 1.0 0.9 5.1 2.2 1.4 11.2 18.9 2.0 18.5 0.5 0.6 29.4 24.5 2.5 5.4 1.0 0.8 2.1 27.3 4.0 2.8 1.4 4.7 6.6 0.3 1.9 2.1 3.7 36.0 0.3 4.5 0.9 13.7 0.4 1.7 0.5 0.3 3.7 2.0 35.4 0.1 11.5 39.1 0.2 20.5 0.0 28.5 2.0 6.3 6.1 8.2 30.4 0.6 0.0 3.1 5.2 6.6 0.0 22.5 0.5 6.8 0.2 6.3 0.1 0.7 32.6 6.7 0.0 8.9 8.1 0.4 1.0 0.0 0.2 0.0 0.0 0.3 0.1 6.6 1.9 0.0 1.0 38.4 0.4 0.2 6.1 13.0 0.0 0.0 0.1 0.0 0.7 0.1 0.3 87.6 59.0 4.1 25.4 0.0 0.0 6.7 3.8 0.1 0.1 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 10.3 10.8 18.4 8.8 11.2 18.9 29.4 24.5 27.3 36.0 13.7 35.4 0.3 0.0 0.0 10.7 0.2 0.4 1.1 0.5 0.0 1.2 2.1 0.8 1.2 4.3 0.2 0.0 4.2 6.0 0.0 1.2 5.9 1.0 0.4 3.8 1.0 0.3 20.4 0.0 5.9 4.0 7.9 1.6 4.6 0.7 0.0 10.2 0.0 20.2 1.1 0.0 4.9 1.7 0.0 1.0 0.0 0.5 0.6 0.1 3.6 0.0 0.0 1.6 0.0 0.5 0.1 2.1 0.6 3.0 0.0 1.0 0.4 2.4 1.1 0.1 0.0 0.3 1.2 0.3 1.5 0.0 0.3 2.3 0.0 3.2 3.5 0.7 GYS1 "GSY, GYS" ENSG00000104812 "Glycogen synthase 1" P13807 19 48968130-48993310 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Glycogen biosynthesis" "Allosteric enzyme, Glycosyltransferase, Transferase" "Diabetes mellitus, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 5 "heart muscle: 118.5;skeletal muscle: 319.4;tongue: 201.6" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 67.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007793, HPA041598" Enhanced Approved Microtubules,Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 54: Cardiomyocytes - Muscle contraction" "Microtubules, Cytosol" "CAB007793: AB_562291, HPA041598: AB_2677571" "unprognostic (3.37e-1)" "unprognostic (3.07e-1)" "unprognostic (1.02e-1)" "unprognostic (1.83e-1)" "unprognostic (1.92e-1)" "unprognostic (2.04e-2)" "unprognostic (6.83e-3)" "unprognostic (2.41e-2)" "unprognostic (1.12e-1)" "unprognostic (3.30e-2)" "unprognostic (1.30e-1)" "unprognostic (4.49e-2)" "prognostic unfavorable (3.46e-4)" "unprognostic (4.04e-2)" "unprognostic (6.76e-2)" "unprognostic (5.87e-3)" "unprognostic (3.81e-2)" 32.4 26.3 17.9 16.2 18.8 46.0 23.7 26.4 23.3 17.1 22.2 21.7 15.3 18.8 8.9 38.2 18.7 10.1 118.5 19.7 17.6 21.8 14.9 16.0 15.5 22.2 20.9 19.7 13.6 15.7 15.5 11.3 19.6 27.4 14.7 19.2 22.2 15.5 319.4 20.7 19.9 16.7 16.4 18.5 23.2 6.1 20.2 14.7 15.9 201.6 14.4 24.3 23.2 18.3 67.3 26.3 19.0 26.3 43.2 16.9 37.6 45.5 31.7 46.8 54.3 25.8 21.3 28.0 27.0 44.7 12.4 46.6 32.0 57.7 40.6 17.4 46.5 23.1 33.3 23.1 24.3 25.4 15.9 41.8 27.2 30.2 25.4 40.5 39.8 28.8 16.4 36.1 59.4 25.4 31.8 21.9 10.2 29.0 29.8 26.6 33.2 27.5 46.7 70.6 11.8 16.4 40.5 52.1 10.4 25.2 27.7 26.1 31.0 57.1 22.0 26.1 50.5 29.8 33.1 13.5 58.3 22.2 13.1 7.7 9.4 6.6 7.0 5.3 8.6 5.2 6.0 6.5 13.4 3.9 4.7 4.4 3.7 10.6 8.0 7.2 8.6 7.1 17.9 18.8 26.4 23.3 19.7 17.6 22.2 20.9 19.6 16.4 20.2 18.3 3.5 0.0 14.2 21.9 5.9 5.1 3.7 11.7 11.4 4.2 7.3 5.5 67.9 2.8 5.8 0.0 16.7 7.6 6.8 13.2 0.0 8.1 0.3 6.9 8.9 7.1 7.2 4.8 14.7 6.9 31.7 5.0 12.8 11.9 4.5 6.7 9.7 5.2 8.3 0.0 16.6 9.2 4.1 7.0 5.7 0.7 5.3 7.2 7.2 4.7 9.8 3.3 10.3 8.5 6.9 11.8 8.2 5.7 9.7 5.4 9.2 6.0 6.2 11.7 0.0 5.0 7.3 1.3 2.9 15.3 4.1 4.0 5.2 3.8 11.7 3.3 GYS2 ENSG00000111713 "Glycogen synthase 2" P54840 12 21536107-21604847 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Glycogen biosynthesis" "Allosteric enzyme, Glycosyltransferase, Transferase" "Disease variant, Glycogen storage disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 30 "liver: 173.8" "Cell type enriched" "Detected in some" 8 "Hepatocytes: 63.6" "Cancer enriched" "Detected in single" 29 "liver cancer: 12.6" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA039482 Approved NA NA "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 2: Hepatocytes - Metabolism" "HPA039482: AB_10795107" "unprognostic (7.22e-3)" "unprognostic (2.85e-2)" "unprognostic (8.88e-2)" "unprognostic (1.78e-2)" "unprognostic (5.68e-2)" "unprognostic (3.16e-1)" "prognostic favorable (7.62e-5)" "unprognostic (1.06e-1)" "unprognostic (1.29e-1)" "unprognostic (1.68e-1)" "unprognostic (4.68e-2)" "unprognostic (2.15e-1)" "unprognostic (1.13e-1)" "unprognostic (4.22e-2)" "unprognostic (6.53e-2)" "unprognostic (1.85e-1)" "unprognostic (2.66e-4)" 3.1 0.0 0.1 0.0 0.0 0.0 1.0 0.1 0.1 2.4 0.0 0.1 0.0 0.0 0.0 5.7 0.0 0.0 0.2 0.0 0.0 0.2 173.8 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.2 0.0 0.0 0.1 5.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 5.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 4.9 0.2 0.0 0.1 0.0 0.0 0.0 0.0 1.4 63.6 0.0 0.0 7.7 0.0 6.1 1.6 0.0 0.0 0.0 0.0 0.0 3.7 0.0 0.0 0.0 5.0 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 HACE1 KIAA1320 ENSG00000085382 "HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1" Q8IYU2 6 104728094-104859919 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Transcription, Transcription regulation, Ubl conjugation pathway" Transferase "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "placenta: 30.6" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 45.9;Excitatory neurons: 118.8;Inhibitory neurons: 84.2;Microglial cells: 45.9;Oligodendrocyte precursor cells: 64.3;Oligodendrocytes: 74.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA046071 Supported "Nuclear bodies,Endoplasmic reticulum" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 28: Placenta - Pregnancy" "Cluster 28: BEWO - Transcription regulation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Endoplasmic reticulum" "Nuclear bodies" "HPA046071: AB_2679524" "unprognostic (6.32e-2)" "unprognostic (3.77e-2)" "unprognostic (2.93e-2)" "unprognostic (1.12e-2)" "unprognostic (3.75e-2)" "unprognostic (3.75e-3)" "unprognostic (1.22e-3)" "unprognostic (4.63e-2)" "unprognostic (7.41e-2)" "unprognostic (1.24e-1)" "unprognostic (1.56e-2)" "unprognostic (2.25e-1)" "prognostic unfavorable (1.17e-5)" "unprognostic (1.12e-2)" "unprognostic (2.06e-1)" "prognostic unfavorable (7.50e-4)" "unprognostic (1.75e-1)" 3.7 3.2 2.7 2.2 4.4 2.9 3.1 5.0 4.8 3.9 0.4 2.6 2.1 3.9 1.1 5.3 3.3 3.1 3.3 3.1 2.5 6.2 1.6 3.6 2.2 1.9 2.6 3.8 1.9 7.2 1.5 30.6 2.3 3.7 1.8 11.5 2.9 4.1 2.2 2.5 2.1 4.0 1.4 2.5 2.4 10.4 3.1 3.9 4.5 4.1 2.4 3.3 2.9 5.8 3.9 2.7 11.3 14.3 6.6 8.8 13.3 7.7 11.9 4.8 7.2 2.5 2.3 2.2 3.4 5.9 8.1 2.6 2.8 5.3 10.0 9.1 7.2 7.7 2.5 3.4 6.6 6.8 2.5 5.9 4.7 6.2 5.2 6.3 8.0 9.2 7.6 2.4 9.6 2.8 5.1 4.1 5.0 2.9 2.6 8.0 12.8 0.9 3.8 6.6 6.1 9.1 4.2 4.3 2.3 7.3 2.7 9.2 8.5 3.9 3.2 10.5 7.4 3.5 4.1 7.6 4.0 6.4 7.1 0.0 0.6 0.7 1.2 1.0 1.3 0.9 1.1 1.1 0.6 0.8 1.2 0.9 0.1 0.8 0.5 0.8 0.4 0.5 2.7 4.4 5.0 4.8 3.1 2.5 1.9 2.6 2.3 1.4 3.1 5.8 11.6 3.2 1.1 42.4 5.1 4.7 2.3 2.3 5.2 11.6 5.3 3.7 6.7 1.5 3.9 5.5 45.9 10.6 4.1 1.5 1.9 1.6 6.2 2.7 6.2 12.9 1.8 3.0 118.8 1.5 5.4 7.1 5.6 3.4 1.3 7.1 4.2 2.6 5.7 16.8 84.2 2.0 0.0 4.1 2.4 4.6 6.2 3.5 1.8 45.9 4.3 6.1 8.2 64.3 74.6 1.4 2.9 3.8 3.7 1.6 3.8 5.7 2.6 31.7 6.6 6.4 6.6 13.2 3.5 5.3 4.7 6.3 6.2 2.9 1.9 1.9 HADHB MTPB ENSG00000138029 "Hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta" P55084 2 26243170-26290465 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Fatty acid metabolism, Lipid metabolism" "Acyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 793.3;skeletal muscle: 950.6;tongue: 1097.1" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 1167.5;Distal tubular cells: 520.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037539, HPA037540, HPA066099" Enhanced Supported Mitochondria No No 61000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 39: Non-specific - Mitochondria" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 54: Cardiomyocytes - Muscle contraction" Mitochondria "HPA037539: AB_10671374, HPA037540: AB_2675531, HPA066099: AB_2685618" "unprognostic (5.15e-2)" "unprognostic (8.72e-2)" "unprognostic (8.21e-2)" "unprognostic (8.67e-2)" "unprognostic (7.70e-2)" "unprognostic (2.59e-2)" "unprognostic (7.29e-2)" "unprognostic (9.70e-2)" "unprognostic (2.01e-1)" "unprognostic (2.09e-1)" "unprognostic (2.03e-1)" "unprognostic (8.94e-2)" "prognostic favorable (1.37e-9)" "unprognostic (2.47e-1)" "unprognostic (2.50e-1)" "unprognostic (2.88e-1)" "unprognostic (9.68e-2)" 127.0 224.7 120.6 51.1 135.4 58.8 91.3 146.4 138.1 65.2 128.0 110.7 224.2 55.9 73.7 101.3 68.8 64.3 793.3 109.0 138.1 231.4 324.8 64.7 54.9 135.9 141.6 78.4 83.7 209.5 48.1 65.6 139.6 77.1 113.2 63.0 104.8 75.0 950.6 74.4 184.4 79.0 141.4 75.8 109.0 67.1 143.3 53.1 90.8 1097.1 62.5 89.2 64.1 152.8 108.2 83.2 56.6 102.2 342.1 190.1 57.9 89.0 134.6 89.0 86.8 100.5 101.7 53.9 60.8 145.3 100.1 82.8 95.2 124.8 109.2 121.1 83.1 123.6 44.9 194.2 145.9 100.6 90.0 183.7 201.6 92.7 149.0 151.0 168.2 81.0 105.2 83.9 189.5 78.0 57.1 190.7 39.8 160.2 89.0 61.7 188.3 103.2 183.3 148.9 27.2 93.7 151.7 169.8 239.5 68.5 105.4 177.9 118.0 83.5 86.9 79.3 65.1 62.6 101.1 94.7 95.5 158.4 84.4 95.7 168.1 66.4 45.2 150.3 57.6 65.5 61.3 56.6 154.2 49.7 55.8 51.3 72.7 88.2 123.3 51.8 94.7 135.6 120.6 135.4 146.4 138.1 109.0 138.1 135.9 141.6 139.6 141.4 143.3 152.8 106.5 48.1 36.5 63.0 48.3 62.1 136.5 183.3 49.5 29.3 49.5 52.3 1167.5 104.4 107.7 97.5 56.3 227.9 42.4 129.5 520.4 124.0 93.4 59.5 49.0 75.2 74.9 85.2 32.7 57.2 75.2 79.5 53.0 60.2 62.8 94.2 69.9 277.6 139.6 13.5 33.0 93.4 114.0 98.1 67.4 99.7 56.5 78.1 88.9 27.2 110.2 65.0 32.0 35.2 47.5 58.4 134.8 62.8 37.1 60.5 376.0 321.1 73.5 80.0 72.3 72.9 80.7 120.4 49.4 53.8 54.7 186.6 45.2 194.0 113.5 110.3 HAS1 HAS ENSG00000105509 "Hyaluronan synthase 1" Q92839 19 51713112-51723991 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 49.6;ovary: 20.8" "Cell type enhanced" "Detected in some" "Basal keratinocytes: 26.6;Bipolar cells: 20.3;Cholangiocytes: 38.6;Fibroblasts: 64.2;Suprabasal keratinocytes: 17.8" "Cancer enhanced" "Detected in some" "pancreatic cancer: 2.0" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in single" 4 "eosinophil: 2.5" "Lineage enriched" "Detected in single" 18 "granulocytes: 2.5" "Cell line enriched" "Detected in some" 4 "U-87 MG: 112.6" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" HPA067602 Approved Supported "Nucleoplasm,Plasma membrane" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 82: Adipose tissue - ECM organization" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 50: Fibroblasts - ECM organization" "Plasma membrane" Nucleoplasm "HPA067602: AB_2685871" "unprognostic (3.56e-2)" "unprognostic (1.19e-1)" "unprognostic (4.43e-2)" "unprognostic (5.26e-4)" "unprognostic (7.17e-3)" "unprognostic (7.05e-2)" "unprognostic (1.02e-1)" "unprognostic (5.49e-4)" "unprognostic (4.80e-2)" "unprognostic (1.99e-2)" "unprognostic (8.43e-2)" "unprognostic (1.72e-1)" "unprognostic (2.30e-11)" "unprognostic (9.12e-4)" "unprognostic (8.99e-2)" "unprognostic (3.73e-4)" "unprognostic (2.43e-2)" 49.6 0.5 1.4 6.3 1.1 3.6 1.3 1.1 1.1 0.1 0.0 2.8 0.1 1.0 0.0 0.8 9.0 5.5 9.2 0.9 2.0 0.5 0.6 3.7 0.0 1.8 0.8 20.8 2.1 0.3 0.9 0.3 0.7 0.2 0.5 0.2 0.2 0.0 0.2 5.4 1.3 0.7 0.3 0.3 1.7 0.3 2.2 0.1 0.7 0.0 0.0 6.3 0.6 1.3 0.0 0.5 0.0 0.0 0.2 0.6 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.7 0.0 0.1 3.2 0.0 27.0 0.0 0.1 0.0 0.0 0.0 0.2 6.8 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.4 0.0 0.3 0.8 0.0 0.0 0.0 0.0 112.6 0.0 0.2 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.0 0.0 0.0 0.0 0.0 1.4 1.1 1.1 1.1 0.9 2.0 1.8 0.8 0.7 0.3 2.2 1.3 1.5 0.0 1.8 0.0 0.2 26.6 0.1 0.8 0.6 20.3 0.0 0.0 1.3 38.6 0.7 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.1 0.5 0.5 0.0 0.0 1.7 0.0 0.2 64.2 2.6 0.0 2.5 0.0 0.0 0.1 0.2 0.0 1.5 0.0 0.0 0.8 9.0 0.2 0.3 8.3 8.8 0.0 0.0 0.2 0.0 0.0 0.9 0.1 0.0 0.4 0.1 0.2 0.0 0.1 0.0 0.5 0.0 3.1 10.6 0.1 0.5 0.4 17.8 0.1 0.3 0.0 0.0 0.2 HAS2 ENSG00000170961 "Hyaluronan synthase 2" Q92819 8 121612116-121641440 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 22.7;urinary bladder: 20.5" "Cell type enhanced" "Detected in many" "Basal prostatic cells: 54.1;Fibroblasts: 62.1;Langerhans cells: 28.9;Melanocytes: 30.2;Smooth muscle cells: 30.7;Urothelial cells: 89.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in many" 4 "HBF TERT88: 157.8;hTEC/SVTERT24-B: 153.8;LHCN-M2: 206.5;U-138 MG: 396.9;U-251 MG: 123.7" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA052060 Approved "Nuclear speckles" NA NA "Cluster 82: Adipose tissue - ECM organization" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "Nuclear speckles" "HPA052060: AB_2681712" "unprognostic (7.01e-2)" "unprognostic (1.34e-2)" "unprognostic (4.07e-2)" "unprognostic (4.65e-2)" "unprognostic (1.17e-1)" "unprognostic (2.91e-2)" "unprognostic (5.33e-2)" "unprognostic (2.57e-3)" "unprognostic (3.44e-2)" "unprognostic (1.34e-1)" "unprognostic (8.19e-3)" "unprognostic (1.24e-1)" "unprognostic (1.66e-7)" "unprognostic (1.47e-3)" "unprognostic (3.67e-2)" "unprognostic (1.23e-1)" "unprognostic (1.54e-3)" 22.7 0.3 0.6 9.0 0.5 0.1 5.3 0.6 0.5 0.7 0.1 4.1 2.8 0.8 1.2 1.6 1.7 7.8 4.0 0.5 1.5 1.1 2.9 3.7 1.6 1.6 2.1 0.2 0.9 0.2 0.3 2.3 1.3 1.1 5.6 0.0 1.0 0.2 0.5 2.3 5.2 3.9 1.1 0.1 2.0 1.8 1.3 0.8 0.7 0.9 0.9 20.5 0.6 0.9 0.3 2.8 0.0 0.4 4.7 11.8 0.0 23.5 17.3 29.9 51.2 0.2 0.4 0.1 0.0 20.8 0.0 4.2 0.0 0.0 157.8 0.1 0.6 0.0 0.6 0.0 19.9 0.0 0.0 31.0 0.0 153.8 14.1 0.7 0.0 0.0 0.0 0.0 206.5 0.3 0.0 0.0 0.4 0.0 3.4 0.0 26.6 0.0 0.0 2.0 0.0 0.4 10.0 0.0 5.6 9.0 0.2 0.3 0.0 396.9 1.4 37.7 123.7 0.0 0.0 0.0 8.5 0.1 8.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.5 0.6 0.5 0.5 1.5 1.6 2.1 1.3 1.1 1.3 0.9 2.2 0.0 0.0 0.0 0.0 16.3 54.1 1.8 0.6 0.0 0.1 0.4 1.2 0.0 0.2 3.7 0.0 0.2 0.2 1.6 0.0 0.9 19.0 0.1 3.5 7.2 1.2 0.0 0.1 0.0 0.0 62.1 1.1 0.1 13.4 0.0 0.7 0.0 0.3 0.0 0.2 2.3 0.0 0.0 28.9 3.4 1.8 0.7 30.2 0.0 0.0 0.0 0.0 16.1 0.2 1.6 1.9 0.0 0.0 11.0 0.0 0.1 0.0 0.0 0.0 6.9 30.7 0.3 0.1 0.6 11.9 0.1 1.5 0.0 3.9 89.3 HAS3 ENSG00000103044 "Hyaluronan synthase 3" O00219 16 69105653-69118719 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 33.5;urinary bladder: 92.8" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 162.3;Basal prostatic cells: 51.6;Basal respiratory cells: 107.1;Suprabasal keratinocytes: 158.6;Urothelial cells: 115.5" "Group enriched" "Detected in many" 8 "cervical cancer: 17.1;head and neck cancer: 44.9;lung cancer: 23.3;urothelial cancer: 31.1" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HaCaT: 52.5;PC-3: 270.5;RT4: 111.6" "Low region specificity" "Detected in some" "Not detected" "Not detected" "HPA031554, CAB033850" Supported Approved Microtubules NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 28: Keratinocytes - Keratinization" Microtubules "CAB033850: AB_2116418, HPA031554: AB_10670703" "unprognostic (3.26e-2)" "unprognostic (1.22e-1)" "unprognostic (5.12e-2)" "unprognostic (1.19e-1)" "unprognostic (2.16e-1)" "unprognostic (7.59e-3)" "unprognostic (2.86e-3)" "unprognostic (1.84e-1)" "unprognostic (3.70e-1)" "unprognostic (1.77e-1)" "prognostic unfavorable (5.36e-4)" "unprognostic (2.46e-1)" "unprognostic (3.27e-3)" "unprognostic (3.25e-2)" "unprognostic (1.32e-1)" "unprognostic (2.21e-2)" "unprognostic (3.40e-3)" 0.8 0.5 0.9 0.7 1.2 0.9 7.5 1.3 1.3 4.6 0.9 5.3 2.9 0.9 1.1 33.5 1.2 4.8 0.7 0.6 1.1 1.1 1.3 20.1 0.4 1.0 1.3 1.4 1.3 0.4 1.7 3.4 1.1 3.7 3.1 0.8 5.4 1.5 1.2 9.7 2.2 0.6 0.4 0.8 12.8 3.5 1.0 0.5 5.9 0.9 2.8 92.8 10.3 1.0 3.5 17.1 1.0 0.9 0.3 0.4 6.6 1.1 0.4 1.0 0.4 3.4 9.0 0.7 2.0 0.4 4.0 52.5 2.9 31.5 1.0 0.2 1.3 0.0 0.2 0.6 0.1 0.3 0.9 0.5 8.6 1.0 3.0 4.0 0.7 0.6 0.1 0.4 0.3 1.8 1.2 0.7 15.5 18.7 270.5 2.0 0.1 0.2 28.3 111.6 19.2 0.8 1.8 0.1 0.3 3.1 0.6 0.8 0.3 0.9 0.9 29.9 1.8 1.0 0.9 0.2 1.0 0.0 0.6 0.1 0.2 0.3 0.2 0.0 0.1 0.1 0.1 0.0 0.1 0.2 0.2 0.1 0.0 0.0 0.1 0.1 0.2 0.2 0.9 1.2 1.3 1.3 0.6 1.1 1.0 1.3 1.1 0.4 1.0 1.0 4.2 0.0 30.8 0.7 0.2 162.3 51.6 107.1 8.6 1.1 1.6 6.1 1.4 0.0 12.2 0.0 2.1 1.0 0.1 16.4 0.0 4.5 10.2 0.7 0.3 2.4 0.0 0.4 1.0 3.6 0.9 1.1 5.1 2.7 0.0 0.4 1.1 0.2 0.3 0.0 2.1 0.7 2.0 0.0 6.5 22.7 1.2 0.5 3.6 0.0 0.0 0.1 0.0 0.5 0.8 2.4 0.2 0.4 0.6 18.4 0.1 0.7 3.0 1.0 0.0 0.9 1.9 0.5 0.7 25.6 158.6 0.3 1.1 0.1 2.2 115.5 HASPIN GSG2 ENSG00000177602 "Histone H3 associated protein kinase" Q8TF76 17 3723903-3726699 "Enzymes, Predicted intracellular proteins" "Cell cycle" "Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "bone marrow: 6.0;lymphoid tissue: 5.3;testis: 7.3" "Cell type enhanced" "Detected in some" "Cytotrophoblasts: 1.2;Extravillous trophoblasts: 3.3" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Not detected" "Not detected" "HPA027422, HPA030698" Approved Supported Nucleoplasm NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "HPA027422: AB_10601812, HPA030698: AB_2673575" "unprognostic (1.15e-2)" "unprognostic (2.78e-2)" "unprognostic (7.06e-2)" "unprognostic (2.14e-2)" "unprognostic (8.05e-2)" "unprognostic (2.81e-1)" "unprognostic (1.01e-4)" "unprognostic (1.57e-2)" "unprognostic (6.60e-2)" "unprognostic (1.77e-1)" "unprognostic (2.75e-3)" "unprognostic (3.82e-3)" "unprognostic (0.00e+0)" "unprognostic (5.65e-3)" "unprognostic (3.09e-2)" "unprognostic (1.31e-1)" "unprognostic (1.73e-1)" 0.2 0.1 0.0 1.8 0.2 6.0 0.4 0.0 0.1 0.2 0.2 1.1 1.5 0.2 0.1 1.3 0.3 0.2 0.1 0.0 0.0 0.1 0.1 1.4 4.2 0.1 0.1 0.1 0.2 0.0 0.0 0.6 0.1 0.3 1.0 0.0 0.4 0.0 0.6 0.7 1.8 0.4 0.0 1.7 0.9 7.3 0.2 5.3 0.3 0.1 5.1 0.3 0.5 0.2 11.3 12.2 11.1 12.5 0.7 1.4 9.3 10.2 7.8 19.7 19.3 9.6 4.6 27.7 5.7 5.7 7.9 18.0 20.1 9.9 18.7 0.1 16.7 13.8 9.9 5.8 0.5 8.1 13.7 0.9 0.8 14.9 9.2 2.4 9.1 21.6 12.4 23.7 10.1 5.9 16.4 4.8 9.8 8.7 8.3 16.8 13.9 7.4 3.0 7.8 4.4 6.5 8.9 6.1 3.5 9.6 6.1 7.5 4.7 8.7 9.9 9.8 18.1 4.5 5.4 13.4 5.1 11.5 10.7 0.1 0.1 0.5 0.0 0.1 0.0 0.1 0.1 0.0 0.2 0.5 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.2 0.0 0.1 0.0 0.0 0.1 0.1 0.1 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 1.2 0.2 0.0 0.0 0.1 0.0 0.1 0.1 0.3 0.0 0.0 0.0 0.0 3.3 0.2 0.0 0.2 0.0 0.9 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.0 0.0 HAT1 KAT1 ENSG00000128708 "Histone acetyltransferase 1" O14929 2 171922448-171983686 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036788, CAB037191" Supported Supported Nucleoplasm NA NA 27000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 52: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Nucleoplasm "CAB037191: AB_477070, HPA036788: AB_10672267" "unprognostic (1.76e-1)" "unprognostic (1.01e-2)" "unprognostic (7.39e-3)" "unprognostic (8.24e-3)" "unprognostic (2.76e-1)" "unprognostic (1.54e-1)" "prognostic unfavorable (5.72e-5)" "unprognostic (2.71e-2)" "unprognostic (9.08e-3)" "unprognostic (3.69e-2)" "unprognostic (1.56e-2)" "unprognostic (1.24e-1)" "unprognostic (3.23e-2)" "unprognostic (6.89e-2)" "unprognostic (1.80e-1)" "unprognostic (3.97e-2)" "unprognostic (6.69e-2)" 27.7 27.0 14.3 33.5 15.5 59.8 41.4 15.9 19.2 26.8 15.3 27.7 19.9 24.6 16.7 26.6 24.4 24.6 31.4 13.1 16.2 32.2 30.2 25.7 48.7 15.0 14.6 23.2 30.0 37.9 16.9 30.6 15.5 29.0 30.7 28.8 32.8 24.0 67.7 23.8 21.7 29.3 16.1 27.7 23.6 20.1 15.5 50.7 32.8 50.8 47.5 39.0 19.6 17.3 132.4 61.5 106.6 98.8 55.2 56.8 75.2 133.9 88.9 144.4 149.9 144.3 88.2 147.0 85.0 81.5 122.7 101.3 116.7 109.5 220.5 83.5 115.8 131.1 91.5 131.0 26.7 165.5 77.9 34.2 62.2 191.0 63.6 45.5 92.6 100.4 136.5 93.1 166.5 91.8 131.1 148.3 89.0 158.9 63.9 102.8 134.4 99.4 85.3 130.2 67.8 55.4 112.4 62.4 118.1 81.5 86.4 164.5 47.5 129.8 99.2 109.5 137.1 40.9 100.5 173.8 87.6 117.8 113.8 47.6 35.3 53.7 32.8 42.0 40.6 35.5 34.9 34.0 27.4 30.7 33.9 37.6 40.3 44.6 59.2 14.3 49.2 34.0 14.3 15.5 15.9 19.2 13.1 16.2 15.0 14.6 15.5 16.1 15.5 17.3 55.6 35.3 28.9 13.7 49.7 74.2 117.7 129.7 46.1 24.2 36.4 42.3 49.5 25.8 66.2 27.6 33.3 77.5 43.5 19.0 82.2 45.2 70.3 33.1 32.3 43.2 14.3 103.1 28.6 46.5 83.1 43.7 15.8 28.9 40.6 30.7 28.9 20.1 51.8 28.6 45.3 20.9 111.9 29.5 36.3 14.7 30.7 34.5 32.0 16.9 28.8 53.4 43.3 21.6 28.0 27.8 21.0 36.9 50.8 52.0 18.2 46.0 65.4 42.0 39.5 43.8 51.3 65.7 67.5 28.8 52.7 58.3 49.0 43.9 29.4 64.1 HCK JTK9 ENSG00000101336 "HCK proto-oncogene, Src family tyrosine kinase" P08631 20 32052197-32101856 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Exocytosis, Host-virus interaction, Immunity, Inflammatory response, Innate immunity, Phagocytosis" "Kinase, Transferase, Tyrosine-protein kinase" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 112.1" "Cell type enhanced" "Detected in many" "Hofbauer cells: 150.7;Kupffer cells: 155.5;Langerhans cells: 89.2;Macrophages: 170.1;Microglial cells: 52.5;monocytes: 222.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 16 "classical monocyte: 575.0;eosinophil: 707.8;intermediate monocyte: 1059.1;myeloid DC: 336.3;neutrophil: 801.3;non-classical monocyte: 1251.7" "Group enriched" "Detected in all" 16 "dendritic cells: 336.3;granulocytes: 801.3;monocytes: 1251.7" "Group enriched" "Detected in some" 9 "THP-1: 69.3;U-937: 199.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "CAB005195, HPA035534, HPA063768" Approved Supported "Vesicles,Plasma membrane,Cytosol" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 2: Immune cells - Immune response" "Cluster 32: U-937 - Innate immune response" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Vesicles "Plasma membrane, Cytosol" "CAB005195: AB_631619, HPA035534: , HPA063768: AB_2685118" "unprognostic (6.22e-2)" "unprognostic (6.16e-3)" "unprognostic (2.26e-2)" "unprognostic (7.98e-2)" "unprognostic (8.83e-2)" "unprognostic (5.50e-2)" "unprognostic (4.09e-2)" "unprognostic (1.72e-2)" "unprognostic (4.34e-2)" "unprognostic (1.59e-1)" "unprognostic (4.08e-2)" "unprognostic (1.21e-1)" "prognostic unfavorable (1.66e-4)" "unprognostic (4.92e-2)" "unprognostic (4.42e-2)" "unprognostic (6.95e-2)" "unprognostic (1.12e-1)" 24.8 9.2 4.7 100.0 5.0 55.2 6.0 5.5 6.0 5.5 13.7 12.8 15.2 3.1 2.6 6.7 7.6 14.4 4.8 4.7 6.2 4.7 14.1 46.0 38.6 9.9 6.8 2.5 4.5 2.1 3.1 20.9 8.3 4.0 13.6 0.5 5.1 4.7 1.6 5.8 17.8 25.3 8.1 112.1 6.7 2.3 8.4 14.5 2.8 6.9 39.3 32.8 4.1 12.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.9 0.0 0.1 0.1 1.3 0.0 0.0 0.1 0.0 4.3 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 15.6 0.0 0.1 0.1 4.9 0.4 0.0 0.0 0.4 0.2 0.6 0.0 0.0 0.3 0.0 0.5 0.0 0.2 0.7 0.0 69.3 0.0 0.0 0.3 0.0 0.1 1.9 0.3 10.3 0.0 199.6 0.0 6.4 575.0 707.8 1.1 1059.1 1.3 48.4 1.1 1.1 336.3 43.0 1.1 0.9 801.3 11.0 1251.7 30.4 1.2 566.4 4.7 5.0 5.5 6.0 4.7 6.2 9.9 6.8 8.3 8.1 8.4 12.0 0.6 6.4 14.0 0.0 17.1 3.1 4.0 0.2 0.6 0.1 0.4 1.3 2.0 1.5 3.9 7.3 0.0 0.9 12.1 0.2 1.9 0.1 2.5 0.1 0.1 3.7 1.8 1.7 1.2 0.6 0.9 1.3 4.6 0.1 6.3 0.1 1.1 2.3 150.7 0.0 1.0 0.5 22.4 155.5 89.2 0.3 0.0 170.1 1.8 52.5 222.0 0.0 4.1 1.5 0.6 0.0 0.0 0.0 0.7 0.5 0.1 0.3 1.5 0.1 0.0 0.6 0.5 0.2 0.3 0.2 1.1 1.6 3.0 0.2 0.9 3.7 HECTD1 KIAA1131 ENSG00000092148 "HECT domain E3 ubiquitin protein ligase 1" Q9ULT8 14 31100112-31207804 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 218.4" "Cell type enhanced" "Detected in all" "Urothelial cells: 302.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002929, HPA054461" Approved Enhanced Nucleoplasm,Nucleoli NA NA "Cluster 46: Basophils - DNA binding" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 22: Epithelial cell types - Mixed function" "Nucleoplasm, Nucleoli" "HPA002929: AB_1850574, HPA054461: AB_2682496" "unprognostic (6.71e-2)" "unprognostic (4.86e-2)" "unprognostic (5.31e-2)" "unprognostic (1.25e-1)" "unprognostic (1.64e-1)" "unprognostic (6.99e-2)" "unprognostic (1.32e-1)" "unprognostic (7.03e-2)" "unprognostic (2.29e-2)" "unprognostic (3.13e-2)" "unprognostic (3.60e-3)" "unprognostic (1.51e-1)" "prognostic favorable (1.20e-6)" "unprognostic (6.53e-2)" "unprognostic (1.22e-1)" "unprognostic (1.07e-1)" "unprognostic (9.91e-3)" 43.0 48.6 27.8 23.1 33.6 54.0 37.6 58.6 33.7 43.5 34.0 38.3 25.1 37.0 30.7 74.6 33.8 26.7 47.2 27.2 30.9 37.0 74.3 32.9 28.7 30.2 30.1 38.5 34.7 56.5 34.4 35.5 32.5 30.7 31.2 66.9 42.6 31.0 218.4 50.8 33.6 30.8 28.0 30.4 43.7 42.7 31.3 26.3 51.3 133.6 37.3 39.8 51.5 36.6 95.1 54.6 49.2 30.4 144.0 77.2 44.7 54.8 54.1 47.4 39.7 41.0 47.8 72.1 57.8 97.3 34.0 62.6 63.2 47.7 69.6 44.5 24.9 75.6 44.3 163.9 66.9 81.8 52.7 66.3 64.4 52.2 80.9 63.6 87.5 42.2 54.4 32.1 72.8 72.4 31.8 31.7 36.0 76.6 47.5 53.6 58.0 30.4 71.3 93.2 36.2 40.8 79.8 54.5 49.0 56.3 58.7 49.5 93.4 56.6 42.9 41.9 49.0 34.3 52.9 79.0 28.0 37.3 49.7 9.1 5.7 8.3 4.5 4.8 5.2 4.8 5.2 4.1 6.4 6.3 4.2 4.3 3.0 6.3 3.8 5.3 5.6 2.4 27.8 33.6 58.6 33.7 27.2 30.9 30.2 30.1 32.5 28.0 31.3 36.6 63.4 48.1 80.8 84.5 60.7 86.7 93.5 61.2 48.3 98.9 40.8 28.6 108.1 25.8 94.8 71.7 98.0 70.2 72.1 40.9 11.7 44.2 3.6 101.6 83.0 60.0 48.7 41.2 89.9 36.1 42.9 59.9 96.8 118.1 32.9 81.6 46.4 84.7 29.0 65.6 101.1 33.0 63.1 43.9 34.5 8.7 69.0 54.0 33.8 90.9 65.1 40.9 78.2 100.0 127.9 52.6 33.9 74.4 71.1 106.3 37.1 22.4 148.4 194.5 46.0 77.4 78.9 50.6 100.0 83.7 114.9 140.0 61.4 97.0 44.5 302.9 HECTD2 FLJ37306 ENSG00000165338 "HECT domain E3 ubiquitin protein ligase 2" Q5U5R9 10 91409280-91514829 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 127.5;Inhibitory neurons: 99.4;Microglial cells: 60.0;Oligodendrocyte precursor cells: 87.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 6 "NK-cell: 2.8" "Lineage enriched" "Detected in single" 6 "NK-cells: 2.8" "Cell line enhanced" "Detected in many" "AF22: 29.0" "Low region specificity" "Detected in all" "Region enhanced" "Detected in all" "cerebellum: 56.1" HPA037767 Approved Approved Nucleoplasm NA NA "Cluster 15: NK-cells - Transcription" "Cluster 89: Fibroblasts - ECM organization" "Cluster 12: NES - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "HPA037767: AB_10671378" "unprognostic (6.35e-2)" "unprognostic (1.33e-1)" "unprognostic (3.26e-2)" "unprognostic (3.34e-1)" "unprognostic (6.65e-3)" "unprognostic (1.10e-2)" "unprognostic (9.37e-4)" "unprognostic (1.42e-1)" "unprognostic (1.59e-1)" "unprognostic (2.31e-1)" "unprognostic (2.54e-3)" "unprognostic (4.44e-2)" "prognostic unfavorable (1.67e-5)" "unprognostic (6.98e-3)" "unprognostic (1.39e-1)" "unprognostic (1.93e-1)" "unprognostic (5.84e-2)" 6.6 5.8 6.9 3.7 7.7 1.6 7.3 8.1 8.7 9.0 2.2 8.3 3.0 12.0 11.3 5.3 9.4 7.9 6.0 7.2 5.2 7.1 3.2 6.9 3.4 3.5 3.6 11.8 5.3 7.5 6.9 7.3 1.9 16.8 5.0 11.7 5.7 16.4 5.8 4.6 4.6 12.6 3.3 3.8 5.5 7.0 5.3 3.8 6.7 7.2 2.3 8.2 7.4 6.8 5.8 2.9 29.0 12.0 6.2 6.8 5.2 4.7 6.2 9.2 8.5 0.3 5.4 0.0 3.9 4.8 5.4 0.4 7.9 3.3 11.3 6.3 9.8 3.4 23.1 1.8 3.1 0.7 2.1 7.0 2.9 6.7 5.7 13.0 7.0 7.1 4.5 14.6 14.5 2.7 3.6 1.8 12.1 0.5 2.9 9.0 19.1 3.5 6.5 1.6 6.8 7.2 9.1 2.0 9.4 8.8 13.2 2.0 7.3 9.2 6.3 0.6 8.9 1.0 2.0 8.2 8.1 0.1 5.4 0.0 0.0 0.0 0.4 0.4 0.3 0.1 0.2 0.3 0.2 0.2 0.2 0.2 0.0 2.8 0.1 0.0 0.0 0.2 6.9 7.7 8.1 8.7 7.2 5.2 3.5 3.6 1.9 3.3 5.3 6.8 9.4 0.0 5.1 45.4 3.5 6.1 8.8 3.6 8.6 20.6 6.3 8.4 7.9 4.3 6.0 5.5 27.1 0.4 1.2 1.1 21.5 2.7 2.8 6.8 14.2 8.9 9.0 1.3 127.5 3.7 0.4 12.8 7.1 7.3 3.8 7.8 8.2 1.2 6.5 28.6 99.4 2.7 4.1 7.0 6.5 2.0 12.2 7.0 7.2 60.0 2.3 13.1 0.0 87.0 21.2 2.5 1.4 14.3 4.5 4.9 0.5 1.4 7.2 9.1 13.1 15.8 10.5 9.5 9.5 8.4 4.4 0.4 3.0 4.5 1.2 4.3 HECTD3 FLJ21156 ENSG00000126107 "HECT domain E3 ubiquitin protein ligase 3" Q5T447 1 45002540-45011324 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 33.7;Proximal enterocytes: 44.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027467 Approved NA NA "Cluster 34: Basophils - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 45: Enterocytes - Digestion" "HPA027467: AB_10600710" "unprognostic (1.86e-1)" "unprognostic (1.19e-2)" "unprognostic (2.39e-1)" "unprognostic (1.58e-1)" "unprognostic (1.18e-1)" "unprognostic (2.05e-1)" "prognostic unfavorable (2.14e-5)" "unprognostic (1.74e-2)" "unprognostic (2.92e-2)" "unprognostic (7.42e-2)" "unprognostic (2.47e-1)" "unprognostic (8.39e-2)" "unprognostic (2.65e-1)" "unprognostic (7.52e-2)" "unprognostic (3.35e-1)" "prognostic favorable (1.85e-6)" "unprognostic (3.19e-1)" 22.8 24.5 19.7 12.3 21.2 15.0 20.0 20.9 20.6 17.1 18.7 33.2 47.2 18.1 16.0 26.4 13.8 12.3 17.0 20.4 20.7 19.6 30.5 14.0 16.5 22.2 20.5 19.5 37.0 26.7 11.9 14.2 22.3 14.8 26.2 7.4 34.1 15.6 39.9 27.9 40.4 14.8 19.8 20.1 22.6 13.6 20.9 12.7 17.0 24.0 14.4 20.4 18.9 22.6 22.1 19.8 12.4 20.1 42.5 26.5 24.3 20.6 31.2 22.3 25.2 28.7 6.8 10.3 17.1 34.1 50.0 20.2 29.7 21.5 20.0 19.3 22.8 16.6 28.4 24.9 37.2 13.0 26.8 28.6 36.5 38.4 14.8 23.2 50.4 17.8 38.0 11.3 28.9 18.8 16.6 10.6 17.1 24.9 29.6 19.5 22.7 15.0 33.2 25.7 29.7 12.4 27.9 47.8 25.5 31.1 15.5 12.0 38.0 25.7 20.4 32.2 23.9 14.4 18.3 5.8 41.3 14.0 12.9 10.7 8.0 8.0 7.3 10.9 6.3 6.0 6.1 6.5 7.3 3.3 5.0 6.1 2.8 4.0 6.3 5.5 6.7 6.5 19.7 21.2 20.9 20.6 20.4 20.7 22.2 20.5 22.3 19.8 20.9 22.6 6.9 3.2 8.2 7.2 5.6 3.8 2.2 3.1 8.6 5.2 8.5 6.2 6.0 8.6 5.8 5.5 6.2 7.1 9.2 33.7 1.9 10.3 1.2 4.0 7.5 7.0 2.4 20.6 5.4 15.5 14.2 7.0 21.4 8.1 6.3 6.4 6.4 14.1 13.6 6.7 5.0 15.1 0.0 15.3 2.9 2.3 14.6 7.8 3.6 4.7 10.2 3.1 5.2 2.0 4.7 13.2 28.1 9.8 9.1 2.8 44.8 6.9 1.4 6.2 6.6 4.5 6.7 4.5 7.4 9.7 6.1 6.0 7.1 13.5 14.9 2.3 HECW1 "KIAA0322, NEDL1" ENSG00000002746 "HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1" Q76N89 7 43112629-43566001 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "brain: 16.4;kidney: 7.8" "Cell type enhanced" "Detected in some" "Early spermatids: 135.6;Excitatory neurons: 533.3;Inhibitory neurons: 157.3;Late spermatids: 72.0;Oligodendrocyte precursor cells: 277.9" "Not detected" "Not detected" "Region enriched" "Detected in many" 4 "cerebral cortex: 16.4" "Group enriched" "Detected in some" 4 "basophil: 4.9;neutrophil: 3.3" "Lineage enriched" "Detected in many" 5 "granulocytes: 4.9" "Cell line enhanced" "Detected in some" "A549: 3.8;GAMG: 3.7;U-266/70: 12.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007203, HPA007593, HPA007609" Uncertain Supported Cytosol NA NA "Cluster 17: Basophils - Unknown function" "Cluster 58: Brain - Synaptic function" "Cluster 29: U-266 - Adaptive immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "HPA007203: AB_2667776, HPA007593: AB_1852305, HPA007609: AB_2117518" "unprognostic (1.40e-1)" "unprognostic (2.85e-3)" "unprognostic (2.57e-1)" "unprognostic (4.39e-1)" "unprognostic (2.43e-2)" "unprognostic (2.80e-2)" "unprognostic (8.65e-4)" "unprognostic (6.93e-2)" "unprognostic (7.30e-2)" "unprognostic (7.31e-2)" "unprognostic (3.43e-2)" "unprognostic (2.67e-2)" "unprognostic (1.43e-3)" "unprognostic (1.64e-2)" "unprognostic (5.23e-3)" "unprognostic (1.89e-2)" "unprognostic (2.42e-2)" 0.1 0.0 1.5 0.2 1.7 0.5 0.2 0.0 16.4 0.1 0.0 0.2 0.0 0.2 0.6 1.0 0.1 1.9 0.0 0.7 0.0 7.8 0.1 0.1 0.4 0.2 0.0 0.3 0.0 0.2 0.0 0.1 0.1 1.3 0.1 2.2 0.4 0.2 0.9 0.6 0.1 0.1 0.0 0.1 0.3 1.8 0.2 0.0 0.5 2.6 0.2 0.3 0.1 3.8 0.0 3.8 0.3 0.5 0.0 0.0 0.0 1.2 2.2 0.1 0.5 0.0 0.0 0.2 2.3 2.2 3.7 0.2 0.0 0.0 0.2 0.1 0.7 0.0 0.3 0.2 0.2 1.1 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.2 0.0 2.3 0.0 0.0 0.0 0.0 1.8 0.1 0.7 0.4 0.0 0.0 0.0 0.0 0.1 0.4 0.4 0.0 0.0 0.2 0.2 0.0 0.0 0.6 0.8 0.9 0.3 12.0 0.4 0.0 2.7 0.3 0.0 4.9 0.8 0.7 0.3 0.5 0.2 0.6 0.3 0.1 0.1 1.0 0.3 0.3 3.3 0.6 0.6 0.9 0.1 0.0 1.5 1.7 0.0 16.4 0.7 0.0 0.2 0.0 0.1 0.0 0.2 3.8 0.0 0.0 0.0 7.8 0.1 0.4 0.3 0.0 0.0 15.4 0.1 0.3 1.4 0.0 0.0 0.0 4.2 0.0 0.0 0.5 0.0 0.0 135.6 1.1 3.6 0.2 0.0 0.0 533.3 0.0 0.1 0.7 0.0 0.7 0.0 0.0 0.4 0.1 0.0 45.4 157.3 0.1 0.0 0.0 1.4 72.0 0.3 0.2 0.0 24.4 0.1 0.6 0.0 277.9 4.8 0.0 1.4 0.4 0.0 0.4 4.3 15.8 0.0 1.9 0.0 0.6 0.4 3.2 3.3 0.3 0.3 0.0 0.6 0.2 0.5 0.3 HECW2 "KIAA1301, NEDL2" ENSG00000138411 "HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2" Q9P2P5 2 196189099-196593684 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 331.5;Hepatic stellate cells: 99.2;Inhibitory neurons: 375.4;Oligodendrocyte precursor cells: 143.2;Oligodendrocytes: 460.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in some" "neutrophil: 4.7;non-classical monocyte: 3.7" "Group enriched" "Detected in many" 8 "granulocytes: 4.7;monocytes: 3.7" "Cell line enhanced" "Detected in many" "HDLM-2: 30.1;hTEC/SVTERT24-B: 16.3;HUVEC TERT2: 20.9;SCLC-21H: 31.6;TIME: 26.3;U-138 MG: 21.7" "Low region specificity" "Detected in all" HPA034609 Enhanced NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 57: Non-specific - Angiogenesis" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA034609: AB_10669993" "unprognostic (2.65e-2)" "unprognostic (3.89e-1)" "unprognostic (1.42e-1)" "unprognostic (9.00e-3)" "unprognostic (2.55e-1)" "unprognostic (4.28e-2)" "unprognostic (7.63e-3)" "unprognostic (1.23e-1)" "unprognostic (2.61e-2)" "unprognostic (7.05e-2)" "unprognostic (4.16e-2)" "unprognostic (2.27e-1)" "prognostic unfavorable (5.18e-5)" "unprognostic (8.05e-3)" "unprognostic (5.20e-2)" "unprognostic (1.49e-1)" "unprognostic (4.48e-2)" 4.1 1.5 2.4 1.2 3.5 0.1 1.7 4.4 6.1 2.2 0.0 0.4 0.4 0.8 0.3 3.1 3.5 2.1 8.1 3.3 0.0 1.6 2.7 5.3 2.0 1.1 0.8 0.2 0.6 4.3 1.2 7.4 2.1 0.4 0.4 2.7 0.9 0.5 1.4 0.8 0.5 1.3 0.0 6.0 0.9 3.5 1.7 0.8 3.8 3.5 2.4 1.0 0.6 8.2 0.1 1.4 2.3 0.0 1.4 4.2 1.6 2.7 7.3 2.1 2.6 0.3 0.1 1.4 0.5 13.4 3.3 3.2 0.9 0.1 4.5 30.1 1.6 0.0 2.3 0.2 0.2 0.5 0.3 1.0 1.3 16.3 5.7 4.1 20.9 0.0 0.2 0.1 6.7 1.8 0.0 0.7 2.5 0.2 1.0 0.0 0.5 0.0 0.1 0.0 31.6 2.5 2.0 0.5 0.0 0.4 0.1 0.2 26.3 21.7 1.4 4.6 0.7 0.2 0.0 1.3 5.4 0.1 0.2 0.1 0.3 0.8 0.0 1.1 0.0 0.4 0.0 0.0 0.4 0.5 0.0 0.0 4.7 0.0 3.7 0.0 0.0 0.1 2.4 3.5 4.4 6.1 3.3 0.0 1.1 0.8 2.1 0.0 1.7 8.2 61.2 0.0 12.1 12.7 3.6 2.2 0.3 0.1 3.4 9.5 1.1 0.8 18.7 0.0 0.1 0.0 0.0 0.2 0.7 0.6 0.0 0.1 11.1 0.4 1.6 34.2 2.4 0.0 331.5 0.0 0.3 4.2 0.5 0.3 1.3 4.9 99.2 1.5 0.1 0.0 375.4 0.6 0.0 7.2 3.0 5.3 0.0 1.4 3.6 14.0 1.2 12.0 0.0 143.2 460.7 0.1 0.0 2.6 3.4 0.4 0.0 0.1 1.0 1.1 0.0 1.2 2.2 0.5 6.1 9.2 1.6 0.1 1.4 0.7 0.1 0.6 HEMK1 MTQ1 ENSG00000114735 "HemK methyltransferase family member 1" Q9Y5R4 3 50569152-50596168 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 5 "Early spermatids: 149.9;Late spermatids: 151.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HDLM-2: 58.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034701, HPA034702" Uncertain NA NA "Cluster 44: Non-specific - Transcription" "Cluster 43: Testis - Unknown function" "Cluster 44: HDLM-2 - Immune response" "Cluster 34: Spermatids - Unknown function" "HPA034701: AB_10601429, HPA034702: AB_10673101" "unprognostic (1.27e-2)" "unprognostic (6.96e-2)" "unprognostic (2.49e-1)" "unprognostic (4.11e-2)" "unprognostic (2.43e-1)" "unprognostic (7.95e-3)" "unprognostic (9.39e-2)" "unprognostic (3.51e-3)" "unprognostic (1.45e-1)" "unprognostic (3.04e-1)" "unprognostic (5.33e-3)" "unprognostic (2.54e-3)" "unprognostic (1.58e-2)" "unprognostic (4.16e-2)" "unprognostic (4.53e-2)" "unprognostic (6.23e-2)" "unprognostic (2.44e-3)" 12.2 18.6 12.9 11.3 13.6 9.1 13.1 13.4 17.1 19.1 18.5 16.4 11.6 14.4 10.8 14.7 17.4 8.6 17.6 12.6 13.3 23.0 29.7 13.9 15.0 13.9 13.9 21.7 22.3 15.4 19.4 10.5 13.8 22.8 10.7 5.7 21.2 11.7 9.8 10.1 15.0 11.0 13.6 19.3 18.9 27.0 13.3 15.3 25.2 12.5 11.5 17.4 15.2 14.7 11.8 7.0 10.5 10.2 23.6 18.3 14.8 13.6 11.1 13.0 16.1 6.0 18.7 11.7 10.6 18.9 13.8 13.3 8.0 31.2 5.6 58.4 6.5 13.4 11.7 8.1 19.9 14.1 9.2 13.9 24.1 13.8 15.8 22.9 15.9 22.3 11.9 11.9 12.4 10.4 24.1 14.9 4.6 13.5 18.6 7.9 5.2 23.2 15.5 13.9 3.8 11.9 5.1 15.1 15.6 13.8 12.1 21.2 7.2 13.8 11.9 11.0 17.2 10.6 5.7 6.6 20.6 18.0 8.1 24.5 12.4 12.3 18.7 9.0 16.8 19.8 14.8 15.6 17.1 17.5 16.1 17.2 2.0 16.1 5.7 22.0 10.8 13.3 12.9 13.6 13.4 17.1 12.6 13.3 13.9 13.9 13.8 13.6 13.3 14.7 5.9 12.8 13.4 9.4 14.0 4.5 13.2 11.1 6.2 11.2 12.5 10.0 14.8 8.6 14.8 7.3 0.0 25.7 14.9 11.3 11.7 13.5 149.9 10.3 7.6 6.4 0.0 8.6 2.1 8.2 18.9 12.3 11.2 8.0 17.1 16.0 16.1 15.2 19.9 6.7 2.6 19.7 12.2 8.1 4.6 151.1 11.5 9.1 8.8 4.7 17.4 12.7 16.5 2.0 4.1 9.7 10.3 8.2 12.5 8.2 19.2 20.0 22.0 20.0 19.7 10.8 8.3 27.3 8.7 9.1 3.4 13.7 13.8 7.8 16.0 10.0 HENMT1 "C1orf59, FLJ30525, HEN1" ENSG00000162639 "HEN methyltransferase 1" Q5T8I9 1 108648290-108661526 "Enzymes, Predicted intracellular proteins" "RNA-mediated gene silencing" "Methyltransferase, RNA-binding, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 72.0" "Group enriched" "Detected in many" 4 "NK-cells: 58.7;Spermatocytes: 178.5;Spermatogonia: 107.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "JURKAT: 71.4;MOLT-4: 68.2;NB-4: 75.3;U-937: 98.6" "Low region specificity" "Detected in many" "Region enriched" "Detected in single" 19 "cerebellum: 9.1" "HPA028464, HPA028497" Uncertain Approved "Plasma membrane,Focal adhesion sites" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 78: Testis - Spermatogenesis" "Cluster 32: U-937 - Innate immune response" "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" "Plasma membrane, Focal adhesion sites" "HPA028464: AB_10600103, HPA028497: AB_10601552" "unprognostic (1.82e-1)" "prognostic favorable (2.56e-4)" "prognostic favorable (9.95e-4)" "unprognostic (2.92e-3)" "unprognostic (1.91e-1)" "unprognostic (3.88e-3)" "unprognostic (2.01e-2)" "unprognostic (1.49e-1)" "unprognostic (7.01e-2)" "unprognostic (1.25e-1)" "unprognostic (2.95e-1)" "unprognostic (1.19e-1)" "prognostic unfavorable (2.48e-5)" "unprognostic (2.53e-1)" "unprognostic (2.43e-1)" "unprognostic (2.18e-1)" "unprognostic (1.65e-1)" 5.4 2.9 8.6 8.0 8.9 13.3 8.0 6.8 9.2 8.5 4.9 6.5 5.0 3.9 4.7 2.7 2.3 6.5 1.8 8.9 9.6 3.4 2.0 4.7 13.5 8.0 8.1 5.2 2.1 0.9 5.3 5.6 8.9 3.7 9.5 3.0 3.0 3.4 3.2 3.8 7.6 3.6 7.8 11.1 4.7 72.0 10.6 18.7 2.2 6.2 11.3 6.2 2.0 8.6 16.9 8.5 0.7 0.0 0.7 0.5 0.1 4.0 1.5 9.4 1.5 24.7 26.0 0.0 8.9 7.5 0.0 0.1 0.0 0.2 5.9 5.5 0.0 42.4 31.7 0.0 8.1 25.4 36.4 7.8 0.5 2.1 0.0 0.0 1.9 71.4 0.0 18.5 0.4 42.8 68.2 75.3 24.0 13.5 3.7 29.3 0.0 1.5 0.0 18.0 40.1 0.0 35.3 9.8 0.1 2.4 0.0 55.7 0.5 0.0 31.4 17.5 0.1 11.2 15.0 0.1 0.0 98.6 0.3 43.3 19.7 43.2 61.8 24.0 55.6 12.6 30.0 56.4 24.6 7.1 24.7 45.1 19.6 55.6 29.8 19.5 31.2 39.9 8.6 8.9 6.8 9.2 8.9 9.6 8.0 8.1 8.9 7.8 10.6 8.6 2.4 0.0 1.1 2.3 5.4 1.7 1.4 6.6 1.2 5.2 8.1 7.1 1.8 14.3 4.0 5.5 0.0 12.8 28.0 4.0 3.9 3.0 12.2 2.2 3.6 3.0 4.9 13.9 5.2 1.3 21.5 5.2 2.6 2.4 7.0 2.9 6.1 0.5 15.8 0.0 3.7 4.0 4.1 11.7 3.3 20.1 5.0 7.5 1.8 3.7 11.2 3.6 58.7 4.0 2.7 2.8 7.4 3.0 8.0 1.2 5.5 0.8 2.8 2.4 6.6 3.0 3.5 178.5 107.7 2.9 1.6 5.2 23.0 8.5 6.1 3.3 HERC1 "p532, p619" ENSG00000103657 "HECT and RLD domain containing E3 ubiquitin protein ligase family member 1" Q15751 15 63608618-63833948 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Transport, Ubl conjugation pathway" "Guanine-nucleotide releasing factor, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 458.8;Inhibitory neurons: 338.0;Oligodendrocytes: 201.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049749 Uncertain NA NA "Cluster 17: Basophils - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA049749: AB_2680866" "unprognostic (9.72e-2)" "unprognostic (7.51e-2)" "unprognostic (3.43e-1)" "unprognostic (3.80e-1)" "unprognostic (2.35e-1)" "prognostic favorable (4.87e-5)" "unprognostic (1.53e-1)" "unprognostic (2.15e-2)" "unprognostic (3.02e-2)" "unprognostic (2.89e-3)" "prognostic favorable (3.66e-4)" "unprognostic (1.24e-1)" "prognostic favorable (1.36e-6)" "unprognostic (2.87e-1)" "unprognostic (3.36e-2)" "unprognostic (9.04e-3)" "unprognostic (3.94e-1)" 10.5 7.4 8.6 10.3 10.1 27.4 12.7 14.1 20.3 13.0 5.2 11.8 5.3 10.8 6.5 8.1 7.6 9.6 15.2 9.3 0.0 9.1 9.1 10.6 13.7 1.7 0.3 18.5 8.4 22.7 8.8 10.3 1.8 8.6 9.2 18.3 8.8 10.3 30.4 12.1 9.9 12.4 0.0 15.2 10.2 11.5 0.0 25.6 14.0 29.3 12.8 9.2 7.9 22.7 13.5 17.1 19.1 6.6 33.3 21.1 6.4 10.3 13.4 10.7 12.3 10.9 5.3 19.8 9.3 19.8 9.7 14.5 31.2 9.0 14.6 15.4 9.6 42.5 26.4 7.8 5.3 31.6 25.1 15.3 8.5 15.1 14.5 9.3 22.7 13.3 44.0 8.6 9.4 21.7 11.3 6.5 9.3 10.4 8.7 12.2 20.6 11.6 4.4 32.9 17.0 8.4 18.2 12.5 10.5 23.0 6.1 12.7 23.6 13.6 12.6 11.9 13.6 9.4 17.4 13.3 7.8 23.3 4.9 24.4 3.8 8.7 4.9 3.4 3.7 5.9 5.5 4.6 3.4 9.5 5.5 5.4 13.5 2.9 6.7 7.5 7.8 1.8 8.6 10.1 14.1 20.3 9.3 0.0 1.7 0.3 1.8 0.0 0.0 22.7 66.0 6.4 39.5 113.0 44.2 14.9 10.6 16.1 17.1 65.3 19.7 17.1 64.8 17.2 19.9 22.0 66.7 8.8 66.1 11.4 1.9 11.0 28.7 13.5 24.0 44.5 10.2 47.5 458.8 14.1 15.1 28.5 34.7 17.8 50.6 36.5 47.2 21.0 16.2 85.8 338.0 13.1 10.2 43.2 27.4 14.3 27.7 39.2 19.6 137.7 36.0 29.9 35.0 160.4 201.5 11.7 14.7 39.9 44.9 12.7 12.5 15.7 16.6 55.0 6.6 34.4 36.0 43.5 31.3 17.1 15.3 8.9 61.1 31.9 14.4 12.1 HERC2 "D15F37S1, jdf2, p528" ENSG00000128731 "HECT and RLD domain containing E3 ubiquitin protein ligase 2" O95714 15 28111040-28322179 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HEL: 54.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017188, HPA048389, HPA074166" Approved Supported "Plasma membrane,Cytosol" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 59: Non-specific - Translation" "Cluster 36: HEL - Hemostasis" "Cluster 40: Granulosa cells - Unknown function" Cytosol "Plasma membrane" "CAB017188: , HPA048389: AB_2680382, HPA074166: " "unprognostic (1.59e-1)" "unprognostic (1.44e-1)" "unprognostic (1.92e-1)" "unprognostic (6.64e-2)" "unprognostic (6.62e-2)" "unprognostic (5.74e-2)" "unprognostic (9.17e-2)" "unprognostic (2.08e-1)" "unprognostic (1.87e-1)" "unprognostic (4.11e-2)" "unprognostic (9.40e-3)" "unprognostic (3.60e-2)" "prognostic favorable (1.41e-7)" "unprognostic (7.66e-2)" "unprognostic (2.10e-1)" "unprognostic (2.34e-2)" "unprognostic (1.71e-1)" 5.3 5.7 2.5 2.3 2.9 4.0 4.9 1.5 3.1 5.5 3.0 9.3 2.6 7.6 1.7 5.2 6.1 2.2 7.4 2.3 1.1 3.7 3.7 5.1 2.3 2.0 1.8 8.3 6.1 5.4 6.3 2.7 2.7 4.4 2.8 5.3 4.8 2.9 14.2 5.3 6.1 3.7 0.4 4.3 6.3 4.8 2.7 4.4 5.8 9.3 2.4 5.6 5.0 6.2 8.5 16.5 11.2 4.7 9.2 6.9 3.2 6.0 7.1 7.6 7.3 8.6 1.1 8.5 7.2 10.4 11.5 8.5 12.0 5.9 5.6 5.2 7.8 54.0 20.2 2.9 3.5 12.8 4.1 5.7 4.5 9.0 11.2 4.9 10.2 7.0 21.2 3.4 7.3 3.9 2.9 4.3 3.4 6.4 7.1 10.2 16.0 0.7 2.6 18.2 12.3 7.1 14.6 4.1 4.5 5.8 4.8 14.8 15.3 14.0 9.2 5.5 9.1 2.2 3.3 7.7 6.5 5.9 7.6 0.1 0.2 0.1 0.3 0.0 0.1 0.2 0.1 0.1 0.2 0.4 0.2 0.1 0.0 0.1 0.1 0.6 0.2 0.1 2.5 2.9 1.5 3.1 2.3 1.1 2.0 1.8 2.7 0.4 2.7 6.2 56.2 22.4 23.5 68.9 34.3 16.4 15.3 18.1 27.9 107.9 39.1 31.2 66.6 21.5 23.6 64.4 148.0 25.9 28.5 31.8 1.9 28.7 13.0 35.0 55.8 73.3 28.1 67.9 88.9 30.4 15.5 34.3 43.3 29.6 3.8 135.0 38.9 36.7 19.0 122.8 82.9 32.1 16.2 22.3 20.7 15.8 56.2 22.1 69.4 84.3 26.9 41.0 45.3 65.9 89.7 36.6 30.8 52.3 56.6 20.5 31.1 19.8 19.6 142.9 65.7 46.0 43.2 72.5 66.4 38.3 21.0 17.8 30.0 62.7 35.5 11.5 HERC3 KIAA0032 ENSG00000138641 "HECT and RLD domain containing E3 ubiquitin protein ligase 3" Q15034 4 88592434-88708541 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 5 "retina: 114.1" "Group enriched" "Detected in some" 9 "Cardiomyocytes: 23.8;Cytotrophoblasts: 7.0;Extravillous trophoblasts: 17.3;Hofbauer cells: 9.3;Syncytiotrophoblasts: 7.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "fHDF/TERT166: 48.2;hTERT-HME1: 68.6" HPA039170 Approved Supported Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 77: Retina - Visual perception" "Cluster 30: Epithelial cell lines - Translation" "Cluster 38: Extravillous trophoblasts - Unknown function" Cytosol "HPA039170: AB_10673414" "unprognostic (2.21e-2)" "unprognostic (1.65e-2)" "unprognostic (9.28e-3)" "unprognostic (3.24e-1)" "unprognostic (6.26e-2)" "unprognostic (1.88e-2)" "unprognostic (1.30e-2)" "unprognostic (1.85e-2)" "unprognostic (9.77e-2)" "unprognostic (6.51e-3)" "unprognostic (3.48e-3)" "unprognostic (2.58e-2)" "prognostic favorable (5.65e-7)" "unprognostic (1.83e-1)" "unprognostic (3.21e-2)" "unprognostic (1.67e-1)" "unprognostic (1.16e-2)" 11.6 10.2 10.6 13.3 13.4 24.3 14.0 24.5 12.5 13.3 9.4 11.4 11.6 9.9 9.6 16.5 10.2 12.0 21.9 9.6 9.5 14.9 12.1 13.6 17.1 13.6 9.4 12.0 9.3 21.1 9.4 10.1 14.0 19.5 12.1 114.1 12.1 10.9 19.3 18.2 12.1 13.6 7.8 16.1 12.8 3.2 10.0 16.8 14.5 24.4 15.0 11.0 15.3 16.8 12.2 2.4 2.4 3.8 15.3 23.9 9.0 14.5 24.2 13.0 8.5 2.8 14.8 12.0 7.9 48.2 6.1 5.2 4.4 14.1 13.0 7.2 3.4 8.9 6.3 1.9 7.9 22.6 15.7 13.2 15.4 12.7 68.6 8.9 14.2 7.5 7.8 6.2 29.5 3.8 17.8 6.7 0.4 9.6 3.9 19.7 16.5 4.5 8.3 2.6 3.4 3.2 20.4 10.7 4.6 3.9 1.9 12.2 25.7 16.7 9.6 19.9 10.4 11.5 3.1 7.5 11.5 10.2 6.1 7.8 4.9 7.3 3.8 5.6 4.4 4.3 4.7 4.0 5.4 4.2 7.0 4.4 16.2 2.4 9.2 2.4 8.1 2.9 10.6 13.4 24.5 12.5 9.6 9.5 13.6 9.4 14.0 7.8 10.0 16.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 23.8 0.0 0.0 0.0 0.0 7.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 17.3 1.2 0.0 0.0 0.0 0.0 0.0 0.0 9.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 7.4 0.0 0.0 0.0 0.0 HERC4 "DKFZP564G092, KIAA1593" ENSG00000148634 "HECT and RLD domain containing E3 ubiquitin protein ligase 4" Q5GLZ8 10 67921899-68075301 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Differentiation, Spermatogenesis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocyte precursor cells: 174.9;Oligodendrocytes: 209.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "BJ: 201.4;fHDF/TERT166: 226.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045453, HPA070301" Uncertain Supported "Nucleoli fibrillar center,Cytosol" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "Nucleoli fibrillar center" "HPA045453: AB_10961917, HPA070301: AB_2686247" "unprognostic (3.66e-2)" "unprognostic (6.31e-2)" "unprognostic (1.58e-1)" "unprognostic (2.30e-1)" "unprognostic (1.42e-1)" "unprognostic (4.23e-2)" "unprognostic (3.51e-2)" "unprognostic (1.01e-3)" "unprognostic (3.54e-1)" "unprognostic (8.57e-2)" "unprognostic (4.94e-3)" "unprognostic (2.25e-2)" "prognostic unfavorable (3.86e-5)" "unprognostic (1.17e-1)" "unprognostic (2.40e-1)" "unprognostic (3.98e-1)" "unprognostic (2.31e-2)" 13.9 19.6 18.2 14.4 18.9 10.9 14.3 19.5 23.5 15.2 15.3 14.1 13.8 14.9 14.0 14.5 13.4 13.3 13.6 20.6 22.4 13.7 16.6 13.9 21.0 19.4 19.7 15.3 11.1 12.0 14.1 16.5 19.4 12.2 15.9 13.9 11.5 11.4 13.5 13.4 14.6 15.6 18.1 18.2 11.6 14.2 21.1 15.2 13.1 12.3 19.4 16.2 14.3 26.7 75.4 30.4 16.7 28.5 47.5 63.9 15.5 201.4 125.5 75.5 47.6 17.5 35.3 29.7 14.3 226.7 40.6 40.9 21.1 28.9 102.0 17.6 9.2 13.7 51.3 12.2 22.6 17.3 21.3 30.2 33.8 39.3 34.4 89.1 47.5 15.0 14.9 14.3 117.4 35.2 11.3 19.9 9.9 15.8 49.0 15.3 7.6 8.2 32.3 23.7 8.7 9.4 66.1 26.4 26.5 37.6 15.4 20.1 65.0 38.2 17.5 94.7 31.9 8.7 11.2 17.8 67.7 32.3 13.6 10.8 5.0 6.6 3.9 4.1 5.0 3.4 4.1 4.5 5.7 3.4 4.1 4.2 6.7 5.2 4.1 1.6 5.6 3.7 18.2 18.9 19.5 23.5 20.6 22.4 19.4 19.7 19.4 18.1 21.1 26.7 29.8 48.1 29.3 127.0 41.0 50.3 33.7 27.2 26.2 50.1 29.1 16.6 23.0 14.3 24.1 18.4 43.8 29.3 38.7 78.7 7.9 19.5 66.4 44.3 45.4 30.9 22.1 32.4 170.2 12.2 40.8 30.3 34.1 70.9 30.4 31.3 28.5 24.5 23.6 53.8 148.8 29.9 26.4 42.9 23.3 47.4 26.8 30.9 17.8 149.9 36.0 18.9 40.2 174.9 209.2 38.6 52.3 19.2 17.4 42.6 37.8 24.9 25.5 45.8 6.6 33.2 28.1 25.2 12.4 23.4 60.9 15.6 40.9 38.5 21.9 48.5 HERC6 FLJ20637 ENSG00000138642 "HECT and RLD domain containing E3 ubiquitin protein ligase family member 6" Q8IVU3 4 88378739-88443097 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Group enriched" "Detected in many" 5 "BJ hTERT+ SV40 Large T+: 116.1;BJ hTERT+ SV40 Large T+ RasG12V: 85.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA035846 Uncertain Approved Nucleoplasm,Cytosol NA NA "Cluster 13: T-cells - Unknown function" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 40: Granulosa cells - Unknown function" Cytosol Nucleoplasm "HPA035846: AB_10673487" "unprognostic (1.95e-2)" "unprognostic (2.71e-1)" "unprognostic (2.23e-2)" "unprognostic (2.67e-2)" "unprognostic (8.61e-2)" "unprognostic (2.98e-2)" "unprognostic (2.78e-2)" "unprognostic (3.27e-1)" "unprognostic (1.49e-1)" "unprognostic (5.95e-2)" "unprognostic (1.52e-2)" "unprognostic (6.22e-2)" "prognostic favorable (7.14e-5)" "unprognostic (1.80e-1)" "unprognostic (2.59e-1)" "unprognostic (8.43e-3)" "unprognostic (3.77e-2)" 4.1 5.5 6.5 5.4 7.2 7.9 6.2 5.2 8.8 14.2 4.3 6.1 5.3 8.5 4.2 20.9 9.7 10.7 9.6 7.0 7.6 6.0 4.8 8.1 5.0 8.2 6.6 8.3 5.4 7.1 4.4 5.5 7.3 8.4 6.1 4.4 30.5 5.1 3.0 4.1 5.3 8.0 11.7 8.2 7.2 3.9 6.9 12.3 4.3 4.7 5.3 6.0 11.2 6.8 6.7 4.5 0.3 0.9 0.3 3.8 1.2 0.8 22.1 116.1 85.8 0.4 8.3 0.0 1.5 2.1 18.8 2.5 10.9 5.7 7.6 13.9 2.2 6.3 3.8 0.6 3.7 11.3 4.2 5.2 1.3 9.1 0.3 7.0 3.4 5.2 0.0 1.5 2.6 4.1 5.3 3.6 1.5 6.0 2.2 3.6 0.1 0.5 7.8 8.2 0.3 2.7 8.2 2.7 13.5 5.6 4.8 2.0 1.2 1.6 2.1 0.2 2.1 0.3 0.1 0.0 5.2 2.5 5.4 4.4 3.2 4.7 6.4 3.4 12.8 3.5 8.9 6.3 2.8 3.0 6.9 4.7 1.9 6.0 7.4 0.3 12.5 4.2 6.5 7.2 5.2 8.8 7.0 7.6 8.2 6.6 7.3 11.7 6.9 6.8 11.4 12.8 10.6 14.4 5.8 2.8 5.2 3.3 4.6 18.1 4.9 4.6 13.9 7.2 9.8 5.5 16.7 5.8 5.0 8.3 0.0 7.8 1.3 6.4 3.9 11.5 1.8 4.8 21.5 17.4 1.8 6.6 5.6 5.0 5.7 25.9 5.3 2.2 5.0 1.7 25.8 2.9 4.1 2.2 0.8 1.6 4.4 4.7 5.4 28.1 5.7 3.7 4.1 24.1 2.8 13.3 2.4 5.7 3.8 8.3 6.2 4.1 14.6 1.0 6.6 2.0 3.6 0.8 2.1 18.4 1.1 2.5 8.2 13.3 2.5 8.0 HGSNAT "FLJ32731, HGNAT, TMEM76" ENSG00000165102 "Heparan-alpha-glucosaminide N-acetyltransferase" Q68CP4 8 43140464-43202855 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Acyltransferase, Transferase" "Disease variant, Mucopolysaccharidosis, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA029578 Approved NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 52: Non-specific - Transcription" "HPA029578: AB_10602423" "unprognostic (5.35e-2)" "unprognostic (4.61e-2)" "unprognostic (4.31e-2)" "unprognostic (1.36e-1)" "prognostic unfavorable (5.46e-4)" "unprognostic (3.94e-3)" "unprognostic (1.10e-1)" "unprognostic (6.54e-3)" "unprognostic (5.02e-2)" "prognostic favorable (6.33e-5)" "unprognostic (2.55e-2)" "unprognostic (5.48e-3)" "unprognostic (2.03e-1)" "unprognostic (1.27e-2)" "unprognostic (1.55e-1)" "unprognostic (1.72e-1)" "unprognostic (3.45e-2)" 32.3 20.0 13.1 17.5 13.0 21.7 27.8 10.6 13.5 35.0 13.8 25.4 18.4 30.1 30.6 24.0 29.0 25.9 23.3 13.3 17.6 20.0 26.6 24.5 11.7 13.3 12.0 35.9 29.9 22.7 30.7 28.4 13.2 26.9 17.2 12.5 25.9 23.3 14.4 35.4 20.9 25.1 11.4 17.6 23.2 7.6 15.8 11.3 26.9 17.6 15.7 25.2 28.7 13.0 27.4 36.0 8.9 18.0 71.7 53.8 13.3 30.5 36.2 21.8 19.3 5.1 39.2 14.8 20.5 42.9 15.2 15.5 4.0 18.5 12.7 6.4 6.9 16.3 22.2 8.1 23.0 3.7 2.5 36.2 25.9 11.7 24.9 34.5 39.2 7.0 7.5 22.1 40.4 10.0 14.8 7.2 8.0 16.3 5.4 1.6 16.1 7.7 36.1 22.8 4.7 14.0 39.0 12.6 17.4 19.0 43.7 20.9 46.3 33.2 5.4 20.9 12.7 17.9 18.2 6.1 26.8 6.3 20.8 0.2 8.8 9.4 2.7 5.4 3.0 1.9 2.3 2.8 15.8 2.1 1.7 1.9 3.2 8.8 8.6 2.0 1.7 5.0 13.1 13.0 10.6 13.5 13.3 17.6 13.3 12.0 13.2 11.4 15.8 13.0 39.1 16.0 31.9 48.0 26.7 18.0 19.5 22.6 8.6 50.6 23.9 21.7 10.5 28.6 17.8 51.5 50.1 39.2 30.1 27.2 3.9 26.7 0.5 23.5 42.1 37.8 24.1 15.3 61.8 28.1 39.4 34.3 32.6 36.5 8.2 51.2 49.6 23.5 29.2 25.2 76.3 28.0 18.3 34.3 58.8 3.2 35.1 43.3 19.6 44.0 33.5 13.5 34.0 50.8 43.8 29.9 17.0 31.6 19.8 20.7 31.4 9.9 23.5 39.6 26.3 30.2 28.2 1.1 3.0 22.3 21.2 30.1 25.0 37.4 21.7 17.7 HIPK1 "KIAA0630, MGC26642, MGC33446, MGC33548, Myak, Nbak2" ENSG00000163349 "Homeodomain interacting protein kinase 1" Q86Z02 1 113929324-113977869 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 142.0" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "MCF7: 176.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016664 Approved Supported Nucleoplasm,Centrosome,Cytosol NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 24: Non-specific - Transcription regulation" "Nucleoplasm, Cytosol" Centrosome "HPA016664: AB_1850725" "unprognostic (2.98e-1)" "unprognostic (3.94e-2)" "unprognostic (4.89e-3)" "unprognostic (2.52e-2)" "unprognostic (6.47e-2)" "unprognostic (9.84e-3)" "unprognostic (4.64e-3)" "unprognostic (7.22e-2)" "unprognostic (7.52e-2)" "unprognostic (1.45e-2)" "unprognostic (1.26e-1)" "unprognostic (1.15e-1)" "unprognostic (8.63e-2)" "unprognostic (1.84e-1)" "unprognostic (2.64e-1)" "unprognostic (1.94e-2)" "unprognostic (1.99e-2)" 19.8 20.0 24.7 20.2 23.5 142.0 16.8 44.5 20.9 24.4 42.4 19.0 12.7 18.1 17.2 23.1 35.0 22.2 18.0 20.6 32.5 18.2 17.8 23.4 20.9 37.2 39.4 22.8 21.8 21.3 20.5 17.7 29.8 15.4 18.9 56.5 15.2 17.7 25.7 23.4 16.8 18.2 36.9 20.7 17.8 47.1 27.5 57.4 29.8 27.1 20.6 19.7 18.8 25.6 23.4 18.8 25.4 19.5 29.2 15.2 17.1 15.8 19.0 22.2 20.9 21.8 8.8 31.4 21.2 25.3 8.2 15.5 33.1 18.6 31.7 23.0 16.7 45.8 23.7 23.0 24.3 36.7 54.2 16.5 26.5 28.3 28.7 20.8 33.2 54.2 31.8 32.8 32.1 176.4 48.8 21.0 26.2 17.1 15.8 29.1 74.4 10.9 19.8 19.9 11.2 15.0 28.9 30.6 20.5 27.9 17.7 52.3 32.6 21.5 29.0 35.3 24.3 20.1 17.2 26.7 23.7 29.3 50.3 2.1 2.5 5.0 3.0 2.1 3.0 0.9 2.7 2.8 1.7 1.1 2.6 3.3 5.8 2.7 1.6 3.7 2.0 1.5 24.7 23.5 44.5 20.9 20.6 32.5 37.2 39.4 29.8 36.9 27.5 25.6 30.1 54.5 37.2 14.4 26.0 61.4 16.2 16.7 15.4 57.7 29.8 20.2 34.6 22.8 24.5 27.6 70.9 10.7 125.8 38.9 5.9 14.6 95.2 147.9 33.4 28.9 37.2 64.4 27.4 21.0 10.3 24.3 20.9 47.0 46.9 26.3 21.8 37.4 22.2 74.0 33.9 25.4 12.2 49.5 77.7 101.4 22.1 50.2 21.4 31.9 43.1 30.6 36.0 21.1 26.5 18.8 22.4 37.2 43.5 33.7 17.8 16.4 116.4 64.8 26.3 36.5 44.3 49.7 31.5 25.6 80.6 14.2 69.7 21.9 28.3 32.7 HIPK2 ENSG00000064393 "Homeodomain interacting protein kinase 2" Q9H2X6 7 139561570-139777998 "Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Apoptosis, DNA damage, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 10 "brain: 397.5" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 463.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 7 "basophil: 27.5" "Lineage enriched" "Detected in many" 7 "granulocytes: 27.5" "Cell line enhanced" "Detected in many" "HDLM-2: 120.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007611 Supported Supported Nucleoplasm NA NA "Cluster 38: Basophils - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 44: HDLM-2 - Immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "HPA007611: AB_1850730" "unprognostic (1.35e-3)" "unprognostic (1.49e-2)" "unprognostic (1.65e-1)" "unprognostic (7.65e-2)" "unprognostic (5.50e-2)" "unprognostic (9.44e-2)" "unprognostic (2.76e-1)" "unprognostic (4.66e-2)" "unprognostic (1.44e-1)" "unprognostic (2.76e-2)" "unprognostic (3.42e-3)" "unprognostic (4.58e-2)" "prognostic favorable (9.99e-4)" "unprognostic (1.38e-1)" "unprognostic (7.82e-2)" "unprognostic (3.93e-3)" "unprognostic (1.03e-2)" 19.8 9.2 253.4 6.9 359.7 15.0 10.3 124.8 187.0 4.3 39.4 6.6 7.4 6.0 4.1 9.2 8.8 4.7 30.3 146.3 235.5 25.5 14.9 10.7 4.1 253.8 268.7 5.5 11.5 11.5 8.9 10.1 192.5 9.3 4.8 27.8 12.1 5.7 23.5 3.0 6.3 3.9 187.4 6.9 14.5 1.9 318.3 6.9 9.3 17.0 4.2 6.0 5.2 397.5 11.7 51.4 23.2 14.3 55.2 39.4 2.7 6.4 6.3 7.0 7.3 3.8 6.3 0.0 14.3 12.1 43.2 0.6 10.7 16.6 17.5 120.9 4.3 53.7 8.7 18.4 31.0 14.9 14.0 60.3 10.5 32.4 47.9 16.5 17.6 10.0 31.7 14.4 54.3 8.9 18.9 10.6 5.9 6.6 34.3 22.1 12.7 1.6 31.5 2.0 14.1 12.9 14.4 0.5 7.0 4.3 7.9 6.0 59.5 24.5 11.6 28.5 31.4 68.7 44.3 10.2 49.4 7.7 13.4 27.5 1.3 3.5 0.2 1.1 0.3 0.6 0.5 0.2 0.6 0.5 1.6 0.5 1.7 0.2 4.1 0.2 0.1 0.7 253.4 359.7 124.8 187.0 146.3 235.5 253.8 268.7 192.5 187.4 318.3 397.5 107.8 16.0 31.2 82.6 45.8 9.3 30.6 24.9 16.5 116.0 65.6 32.6 213.9 55.8 35.6 64.4 152.2 8.8 72.0 38.4 35.2 32.5 3.1 39.1 12.2 80.3 67.2 18.5 17.8 67.0 1.5 28.1 70.8 41.7 44.9 24.3 151.0 145.2 15.7 222.1 36.3 32.2 63.1 119.5 10.9 4.0 13.1 53.2 44.4 49.6 47.6 78.0 95.8 145.3 463.7 63.4 24.6 18.8 97.9 118.9 22.5 75.0 48.7 62.9 46.0 96.6 60.8 2.7 4.8 42.5 9.5 9.6 30.5 20.1 29.3 43.9 HIPK3 "DYRK6, FIST3, PKY, YAK1" ENSG00000110422 "Homeodomain interacting protein kinase 3" Q9H422 11 33256672-33357023 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA028069 Approved Supported "Nuclear bodies,Cytosol" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Cytosol "Nuclear bodies" "HPA028069: AB_10601815" "unprognostic (2.41e-3)" "unprognostic (1.02e-1)" "unprognostic (4.61e-1)" "unprognostic (5.74e-2)" "unprognostic (2.09e-1)" "unprognostic (1.78e-2)" "unprognostic (1.63e-1)" "unprognostic (7.29e-2)" "unprognostic (1.61e-1)" "unprognostic (2.78e-1)" "unprognostic (2.18e-1)" "unprognostic (2.68e-1)" "unprognostic (3.29e-3)" "unprognostic (7.89e-3)" "unprognostic (1.80e-1)" "unprognostic (1.87e-1)" "unprognostic (2.48e-2)" 57.8 21.5 29.5 25.3 31.5 23.3 35.1 32.9 23.4 27.6 75.9 30.7 16.7 33.1 24.2 30.9 31.7 30.6 53.7 19.9 42.1 38.2 29.8 26.9 22.8 35.5 36.2 27.2 25.8 46.7 12.8 34.7 27.8 23.3 20.6 22.4 22.9 26.1 69.0 22.3 20.2 39.3 34.2 30.6 22.1 18.9 43.1 25.5 33.7 85.3 24.7 32.3 22.4 33.0 19.3 18.0 13.4 15.1 60.5 37.9 12.9 20.0 23.1 15.9 13.3 19.9 13.8 20.7 16.3 24.4 8.0 24.3 10.2 22.2 22.1 30.8 15.8 21.0 20.3 15.2 25.0 22.9 12.8 35.8 42.8 6.1 17.7 16.5 19.4 14.8 6.4 40.4 26.0 10.1 19.2 15.8 3.4 17.3 11.1 25.4 47.3 19.9 26.4 29.4 2.0 11.3 27.1 30.7 18.7 14.2 34.6 41.2 25.8 24.8 16.9 28.9 14.6 21.7 37.2 21.4 11.9 23.5 23.7 10.6 12.7 6.1 4.0 9.4 5.0 2.8 3.6 4.3 14.0 3.3 3.2 4.0 21.1 4.4 11.1 1.7 4.0 5.0 29.5 31.5 32.9 23.4 19.9 42.1 35.5 36.2 27.8 34.2 43.1 33.0 122.2 12.8 44.7 46.0 29.6 66.5 42.8 21.3 39.3 16.2 35.8 25.8 159.9 37.1 32.9 33.1 18.8 18.6 31.2 32.7 5.9 13.0 21.8 76.5 80.5 96.5 37.1 20.6 44.9 24.9 13.4 59.2 23.0 49.0 14.5 24.3 57.5 53.2 30.7 32.0 48.0 28.4 12.2 102.0 76.0 26.1 42.9 68.1 58.7 73.1 69.1 16.2 25.7 45.8 69.1 21.5 21.1 37.6 24.9 52.6 40.7 35.0 65.4 24.9 52.6 83.4 56.4 10.7 8.1 33.4 75.0 15.5 29.8 12.5 25.2 51.2 HIPK4 FLJ32818 ENSG00000160396 "Homeodomain interacting protein kinase 4" Q8NE63 19 40379271-40390181 "Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 15 "brain: 7.7;testis: 18.1" "Group enriched" "Detected in some" 6 "Early spermatids: 101.4;Late spermatids: 32.9" "Not detected" "Not detected" "Region enhanced" "Detected in many" "basal ganglia: 7.7" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 23: Spermatids - Flagellum & Golgi organization" "unprognostic (2.07e-2)" "unprognostic (6.25e-2)" "unprognostic (2.58e-2)" "unprognostic (5.53e-3)" "unprognostic (4.00e-2)" "unprognostic (1.36e-1)" "unprognostic (3.69e-2)" "unprognostic (2.52e-3)" "unprognostic (1.08e-1)" "unprognostic (7.48e-3)" "unprognostic (8.85e-2)" "unprognostic (9.09e-2)" "unprognostic (3.06e-2)" "unprognostic (8.71e-3)" "unprognostic (3.64e-2)" "unprognostic (2.03e-2)" "unprognostic (4.63e-2)" 0.2 0.1 1.3 0.0 7.7 0.0 0.2 1.1 3.6 0.3 0.0 0.5 0.0 0.4 0.0 0.2 0.2 0.0 0.4 5.1 0.0 0.1 0.1 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.1 0.1 0.0 0.8 0.2 0.1 0.0 0.0 0.0 0.1 18.1 0.3 0.0 0.1 0.0 0.0 0.3 0.1 0.2 0.0 0.6 0.0 0.4 0.0 0.0 0.0 0.1 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.2 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.3 7.7 1.1 3.6 5.1 0.0 0.0 0.0 0.0 0.0 0.3 0.2 1.6 0.0 0.0 0.0 0.0 0.5 0.3 0.0 0.6 0.0 0.7 1.8 1.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 101.4 0.1 0.3 0.6 0.0 0.0 8.4 0.0 0.0 0.6 0.0 0.4 0.0 0.1 0.0 0.0 0.1 0.0 4.9 0.0 0.0 0.0 0.7 32.9 1.5 0.3 0.0 1.9 0.0 0.0 1.0 0.0 0.5 0.1 0.0 0.7 0.1 0.1 0.0 0.1 0.0 0.0 0.0 4.2 0.7 10.3 0.5 1.1 0.3 0.0 0.1 0.2 0.0 0.1 HK1 ENSG00000156515 "Hexokinase 1" P19367 10 69269984-69401884 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Glycolysis, Immunity, Inflammatory response, Innate immunity" "Allosteric enzyme, Kinase, Transferase" "Cancer-related genes, Charcot-Marie-Tooth disease, Disease variant, Mental retardation, Neurodegeneration, Neuropathy, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 4 "Early spermatids: 374.0;Horizontal cells: 304.5;Late spermatids: 1034.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007043, HPA007044, CAB010052" Supported Supported Mitochondria NA NA 560000 "Cluster 51: Monocytes - Innate immune response" "Cluster 39: Non-specific - Mitochondria" "Cluster 1: K-562 - Erythropoiesis" "Cluster 25: Spermatids - Spermatogenesis" Mitochondria "CAB010052: AB_627721, HPA007043: AB_1850652, HPA007044: AB_1079049" "unprognostic (8.80e-2)" "unprognostic (1.78e-1)" "unprognostic (2.03e-1)" "unprognostic (2.00e-3)" "unprognostic (1.15e-2)" "prognostic unfavorable (3.39e-6)" "unprognostic (1.23e-1)" "unprognostic (1.97e-1)" "unprognostic (4.29e-2)" "unprognostic (1.16e-1)" "unprognostic (3.93e-3)" "unprognostic (1.12e-1)" "unprognostic (1.37e-3)" "unprognostic (7.25e-2)" "unprognostic (1.40e-2)" "unprognostic (2.00e-3)" "unprognostic (3.86e-2)" 47.0 24.4 61.0 45.0 65.7 60.3 40.6 58.0 76.6 54.7 64.2 60.1 13.1 41.3 11.2 129.9 37.0 25.7 150.8 69.1 62.7 49.2 8.5 48.1 34.1 56.7 59.8 19.9 12.3 25.0 44.9 49.3 71.1 52.9 31.9 147.6 67.1 53.1 193.5 102.6 29.2 49.8 40.0 40.3 61.6 77.2 53.5 44.9 71.0 146.7 47.6 74.3 80.9 54.1 101.6 56.6 74.2 71.1 81.0 60.4 47.1 98.3 256.5 128.5 138.0 16.3 11.0 7.3 75.8 165.9 92.9 86.2 69.9 220.0 122.0 67.5 54.5 250.0 58.3 1.1 91.7 5.1 181.2 91.5 125.8 184.5 407.6 160.8 135.4 36.8 424.5 51.3 178.7 167.7 29.7 13.1 113.8 51.7 247.0 44.8 45.0 0.6 88.7 117.4 75.7 88.7 112.6 215.4 65.2 104.3 117.7 16.5 140.4 190.5 86.4 106.5 139.6 61.1 42.8 17.4 247.3 130.4 56.1 68.7 88.8 44.6 41.5 125.2 69.0 33.5 47.9 47.6 81.0 19.9 41.7 33.9 20.9 31.2 135.4 9.1 58.1 110.4 61.0 65.7 58.0 76.6 69.1 62.7 56.7 59.8 71.1 40.0 53.5 54.1 26.1 25.6 32.4 38.2 26.5 48.3 50.5 37.8 43.9 83.9 33.1 21.7 130.6 4.3 34.2 27.6 54.2 70.6 14.6 30.3 13.7 28.6 374.0 32.6 28.0 37.9 18.7 104.8 53.8 30.6 93.3 30.3 41.3 34.5 23.4 72.6 26.7 1.1 49.4 304.5 49.8 28.7 44.7 41.7 21.9 1034.1 15.2 51.3 37.4 29.0 35.3 32.9 20.6 14.1 3.5 54.6 11.1 18.4 19.1 29.1 0.7 1.1 30.7 95.5 19.7 22.2 43.1 5.3 6.2 86.0 51.7 118.9 30.5 28.3 19.3 43.5 HK2 ENSG00000159399 "Hexokinase 2" P52789 2 74834127-74893359 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Glycolysis "Allosteric enzyme, Kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "retina: 144.0" "Cell type enhanced" "Detected in many" "Distal enterocytes: 216.4;Early spermatids: 89.5;Paneth cells: 108.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "eosinophil: 51.7" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "U-87 MG: 172.5" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA028587, HPA061711" Enhanced Supported Vesicles,Centrosome,Mitochondria,Cytosol NA NA 100000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 54: Non-specific - Microtubule organization" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 53: Intestinal epithelial cells - Unknown function" "Mitochondria, Cytosol" "Vesicles, Centrosome" "HPA028587: AB_10602605, HPA061711: " "unprognostic (1.28e-1)" "unprognostic (1.52e-3)" "unprognostic (3.02e-1)" "unprognostic (3.63e-2)" "unprognostic (1.69e-1)" "unprognostic (7.21e-2)" "prognostic unfavorable (3.65e-4)" "unprognostic (2.85e-2)" "unprognostic (2.57e-1)" "unprognostic (2.17e-1)" "unprognostic (4.43e-3)" "unprognostic (2.24e-2)" "prognostic unfavorable (1.37e-4)" "unprognostic (1.20e-1)" "unprognostic (1.17e-1)" "unprognostic (1.42e-1)" "unprognostic (7.67e-2)" 58.2 2.7 2.7 14.6 3.9 45.7 16.0 4.8 5.6 7.8 2.7 46.6 2.8 5.1 66.1 19.9 9.7 9.5 7.9 3.5 3.6 1.9 2.7 15.2 5.8 11.1 6.3 14.9 2.9 2.5 1.9 13.1 8.5 4.9 37.3 144.0 14.7 1.1 45.6 14.6 13.0 3.3 5.9 6.9 18.7 32.8 6.0 3.7 14.1 83.7 7.8 27.1 15.9 8.6 55.9 0.4 12.5 45.4 103.3 10.8 46.5 21.3 30.6 23.4 33.4 44.0 9.8 40.7 20.1 9.9 30.2 19.0 57.0 44.7 67.0 11.6 12.5 55.1 12.4 61.0 32.5 80.8 86.3 18.2 47.3 44.5 77.1 26.3 11.3 23.0 49.2 0.2 6.9 39.6 19.8 82.0 45.3 52.4 38.2 31.8 26.2 31.7 14.2 77.2 9.2 44.6 13.5 67.4 27.4 17.8 3.6 12.8 9.4 74.0 13.4 31.2 39.2 27.1 8.2 20.2 172.5 57.9 19.9 16.8 14.0 51.7 0.2 11.0 0.6 1.2 0.8 0.1 11.8 1.3 1.2 1.2 11.2 0.0 7.7 0.3 1.5 4.7 2.7 3.9 4.8 5.6 3.5 3.6 11.1 6.3 8.5 5.9 6.0 8.6 1.6 16.0 45.3 4.9 5.7 51.6 9.5 26.7 5.7 14.8 16.0 5.6 7.2 4.3 24.2 5.5 83.4 2.3 0.6 216.4 0.0 4.6 89.5 5.8 4.1 4.4 39.0 4.2 0.2 4.5 33.5 6.4 14.8 15.0 22.2 27.2 1.4 0.3 15.8 21.9 0.1 37.7 6.1 20.8 35.1 46.0 14.6 22.8 23.2 25.3 18.9 6.3 2.1 0.5 0.7 25.6 108.3 7.9 4.7 34.3 5.4 0.2 15.2 42.1 13.1 19.9 3.3 3.9 4.2 10.7 57.0 8.2 3.6 5.8 51.7 70.0 HK3 ENSG00000160883 "Hexokinase 3" P52790 5 176880869-176899346 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Glycolysis "Allosteric enzyme, Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "bone marrow: 129.3;lymphoid tissue: 76.6" "Group enriched" "Detected in some" 13 "Early spermatids: 11.1;Hofbauer cells: 34.5;Kupffer cells: 43.9;Macrophages: 38.8;monocytes: 14.6" "Low cancer specificity" "Detected in many" "Group enriched" "Detected in some" 7 "cerebellum: 1.4;cerebral cortex: 1.6;thalamus: 2.4" "Immune cell enhanced" "Detected in many" "basophil: 569.7" "Group enriched" "Detected in many" 13 "granulocytes: 569.7;monocytes: 200.9" "Cell line enriched" "Detected in some" 5 "U-937: 20.6" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" HPA056743 Enhanced NA NA 2000000 "Cluster 10: Basophils - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 32: U-937 - Innate immune response" "Cluster 19: Monocytes & Neutrophils - Innate immune response" "HPA056743: AB_2683222" "unprognostic (4.22e-2)" "unprognostic (4.07e-2)" "unprognostic (1.23e-1)" "unprognostic (8.63e-2)" "unprognostic (2.02e-2)" "unprognostic (1.39e-1)" "unprognostic (8.69e-2)" "unprognostic (2.11e-1)" "unprognostic (5.37e-2)" "unprognostic (1.39e-1)" "unprognostic (1.96e-2)" "unprognostic (3.82e-1)" "prognostic unfavorable (3.84e-8)" "unprognostic (7.02e-2)" "unprognostic (6.01e-3)" "unprognostic (1.46e-1)" "unprognostic (5.42e-2)" 8.4 4.5 0.0 19.0 0.2 129.3 2.6 1.4 1.6 0.8 0.2 2.5 2.0 1.0 0.1 0.9 5.1 2.1 4.0 0.2 0.0 1.8 5.2 25.1 4.2 0.0 0.0 1.0 1.5 0.1 0.7 2.8 0.0 1.1 1.4 0.1 1.5 0.3 0.9 0.5 3.1 7.9 0.0 76.6 2.1 1.3 2.4 1.4 1.3 0.5 0.7 4.5 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 4.5 0.1 0.2 0.0 0.0 0.0 0.0 3.7 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 20.6 0.0 569.7 92.5 204.8 0.3 179.4 0.2 0.4 0.2 0.1 30.2 0.2 0.1 0.1 32.2 0.2 200.9 1.4 0.2 43.6 0.0 0.2 1.4 1.6 0.2 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 1.1 0.7 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 11.1 0.1 0.0 0.1 0.0 0.0 0.4 0.0 0.2 0.2 0.0 0.4 1.3 0.0 0.4 0.2 34.5 0.0 0.4 0.0 0.0 43.9 0.9 1.8 0.0 38.8 0.0 1.0 14.6 0.0 2.1 0.0 0.1 0.1 0.0 0.4 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.4 0.2 0.2 0.1 0.3 0.3 0.1 0.0 0.0 HKDC1 "FLJ22761, FLJ37767" ENSG00000156510 "Hexokinase domain containing 1" Q2TB90 10 69220332-69267552 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Glycolysis "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 53.5;retina: 46.8" "Cell type enhanced" "Detected in many" "Cholangiocytes: 31.5;Distal enterocytes: 29.0;Ductal cells: 32.6;Endometrial ciliated cells: 50.0;Glandular and luminal cells: 55.2;Muller glia cells: 126.9;Proximal enterocytes: 56.3" "Cancer enhanced" "Detected in many" "colorectal cancer: 20.3" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 4 "memory CD4 T-cell: 3.1;naive CD4 T-cell: 5.8;naive CD8 T-cell: 2.3;T-reg: 5.4" "Lineage enriched" "Detected in single" 23 "T-cells: 5.8" "Cell line enhanced" "Detected in some" "A549: 40.1;CACO-2: 57.5;CAPAN-2: 111.4;EFO-21: 33.9;GAMG: 45.4;Hep G2: 33.6;RPTEC TERT1: 81.9" "Region enhanced" "Detected in many" "cerebral cortex: 11.9" "Low region specificity" "Detected in all" "HPA064198, HPA064230" Enhanced Enhanced Mitochondria No No "Cluster 20: T-cells - T-cell receptor" "Cluster 56: Intestine - Transmembrane transport" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 5: Muller glia cells - Visual perception" Mitochondria "HPA064198: AB_2685210, HPA064230: AB_2685219" "unprognostic (1.29e-2)" "unprognostic (2.26e-2)" "unprognostic (1.86e-1)" "unprognostic (8.47e-2)" "unprognostic (1.55e-1)" "unprognostic (3.05e-1)" "unprognostic (6.31e-3)" "unprognostic (5.03e-2)" "unprognostic (1.08e-1)" "unprognostic (1.19e-1)" "unprognostic (1.23e-3)" "unprognostic (3.11e-1)" "unprognostic (1.04e-3)" "unprognostic (1.35e-1)" "unprognostic (2.24e-1)" "unprognostic (2.10e-3)" "unprognostic (2.19e-1)" 0.1 0.0 1.1 2.7 1.3 0.0 0.0 1.4 1.0 1.1 1.4 6.8 53.5 0.9 0.0 0.1 4.6 6.8 0.0 1.0 1.1 13.3 4.6 1.5 1.0 1.3 2.1 0.0 6.2 0.0 0.3 0.0 1.7 0.0 4.2 46.8 0.1 0.0 0.0 0.1 48.0 0.5 1.4 0.3 1.1 1.0 1.0 5.2 9.3 0.0 0.2 0.0 0.1 1.2 1.2 40.1 0.2 0.1 0.0 0.0 0.2 0.0 0.3 0.1 0.1 57.5 111.4 0.0 33.9 0.3 45.4 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.5 33.6 2.7 0.0 0.0 0.0 0.3 0.4 3.2 0.6 0.0 11.3 0.0 0.0 0.7 0.1 0.2 0.1 0.0 11.9 1.3 0.0 1.2 0.1 81.9 0.1 0.0 0.0 0.0 0.0 1.3 0.3 0.0 0.0 0.0 0.4 1.6 0.2 0.8 0.0 0.1 0.0 8.1 0.0 0.5 0.0 0.0 0.0 0.6 0.0 0.5 0.0 3.1 1.0 0.0 0.0 5.8 2.3 0.0 0.2 0.0 0.0 5.4 1.0 1.1 1.3 1.4 1.0 1.0 1.1 1.3 2.1 1.7 1.4 1.0 1.2 0.0 3.2 4.8 11.8 0.7 0.0 0.0 0.3 0.0 1.9 0.0 0.0 1.0 31.5 1.0 16.5 0.0 0.0 0.2 29.0 1.9 32.6 0.6 50.0 4.5 0.5 0.0 0.0 0.4 7.3 0.0 0.2 1.5 55.2 0.0 0.0 0.0 0.4 0.1 3.3 0.5 5.6 0.0 0.3 0.0 0.2 0.3 0.4 0.0 0.0 0.0 126.9 0.0 0.0 0.5 25.5 12.7 0.0 0.3 0.0 56.3 15.7 0.3 5.1 0.0 0.1 0.4 0.0 0.2 0.0 0.0 0.0 1.3 0.1 5.6 0.3 HLTF "HIP116A, HLTF1, RNF80, SMARCA3, SNF2L3" ENSG00000071794 "Helicase like transcription factor" Q14527 3 149030127-149086554 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Transcription, Ubl conjugation pathway" "Activator, Chromatin regulator, DNA-binding, Helicase, Hydrolase, Multifunctional enzyme, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 143.4;Spermatogonia: 113.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015284, HPA049001" Uncertain Enhanced Nucleoplasm NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 21: Non-specific - Transcription" "Cluster 6: T47d - Mammary gland" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" Nucleoplasm "HPA015284: AB_1857263, HPA049001: AB_2680594" "unprognostic (3.21e-2)" "unprognostic (3.46e-2)" "unprognostic (6.81e-2)" "unprognostic (1.95e-3)" "unprognostic (4.29e-1)" "unprognostic (1.29e-1)" "prognostic unfavorable (7.27e-4)" "unprognostic (3.01e-2)" "unprognostic (2.13e-2)" "unprognostic (2.27e-1)" "unprognostic (4.78e-2)" "unprognostic (9.00e-3)" "unprognostic (1.39e-1)" "unprognostic (2.94e-1)" "unprognostic (3.42e-1)" "unprognostic (2.83e-2)" "unprognostic (1.07e-2)" 12.2 23.6 10.3 7.4 11.9 11.5 13.8 20.7 12.0 11.1 17.6 9.9 5.3 13.6 10.2 7.5 11.5 9.3 19.0 10.3 13.4 16.9 18.5 7.8 11.9 13.1 12.6 18.8 13.6 17.2 12.4 8.2 13.9 15.7 7.5 27.6 11.1 11.6 11.6 5.6 6.8 12.1 15.1 8.7 9.9 44.7 12.2 15.8 21.0 11.4 11.2 8.3 6.0 17.5 66.7 31.8 44.3 34.6 29.0 37.3 4.3 44.1 26.2 32.0 37.0 25.8 45.1 42.7 52.3 20.6 62.3 1.9 60.1 17.5 52.9 23.7 29.1 102.6 23.6 10.5 18.1 27.2 40.7 23.7 9.3 23.9 13.9 48.4 18.7 68.1 36.5 26.9 44.2 33.5 56.4 40.9 33.5 33.3 39.3 64.2 49.8 6.6 26.2 21.1 43.5 25.6 66.9 30.4 60.8 23.3 91.5 25.9 13.2 37.1 22.4 53.1 48.5 39.3 23.5 55.4 36.2 36.3 14.6 8.2 1.0 3.5 4.3 1.7 8.0 6.9 3.8 5.8 3.4 4.9 5.6 5.7 0.0 4.7 1.9 7.8 3.9 2.8 10.3 11.9 20.7 12.0 10.3 13.4 13.1 12.6 13.9 15.1 12.2 17.5 19.5 25.6 20.4 56.8 15.6 5.6 8.5 12.9 10.8 99.3 20.1 16.5 46.4 18.6 18.5 31.3 41.7 10.2 29.9 1.9 35.2 10.1 9.9 36.7 31.1 14.3 4.9 71.5 67.5 8.4 10.1 27.6 12.8 11.7 55.7 55.8 13.2 17.2 8.7 47.1 88.7 6.9 18.3 4.6 3.1 12.3 33.8 11.9 5.4 28.1 5.2 35.4 12.3 66.4 68.7 7.4 3.6 32.4 19.3 8.2 2.0 19.2 26.2 76.2 13.1 37.5 23.8 143.4 113.2 11.5 4.3 1.6 22.1 100.6 7.5 6.6 HMBS "PBGD, PORC, UPS" ENSG00000256269 "Hydroxymethylbilane synthase" P08397 11 119084866-119093549 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Heme biosynthesis, Porphyrin biosynthesis" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 6 "bone marrow: 170.8" "Cell type enriched" "Detected in many" 15 "Erythroid cells: 935.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006114, HPA050659" Supported Approved "Lipid droplets" NA NA 21000000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 1: K-562 - Erythropoiesis" "Cluster 6: Erythroid cells - Oxygen transport" "Lipid droplets" "HPA006114: AB_1079067, HPA050659: AB_2681206" "unprognostic (6.24e-2)" "unprognostic (9.10e-3)" "unprognostic (1.42e-2)" "unprognostic (4.98e-2)" "unprognostic (1.04e-1)" "unprognostic (1.30e-1)" "unprognostic (2.29e-3)" "unprognostic (2.81e-1)" "unprognostic (2.18e-1)" "unprognostic (1.13e-2)" "unprognostic (6.83e-2)" "unprognostic (5.06e-2)" "unprognostic (2.90e-3)" "unprognostic (3.91e-3)" "unprognostic (9.53e-2)" "unprognostic (1.32e-1)" "unprognostic (6.11e-2)" 10.3 15.9 9.3 9.3 10.4 170.8 9.4 11.5 10.4 7.9 10.1 13.7 12.5 10.2 11.9 14.4 7.7 4.0 17.3 9.1 10.0 12.3 22.8 8.8 9.2 10.7 10.2 3.8 16.2 9.2 8.5 10.6 10.6 8.6 14.9 5.9 9.9 8.6 30.4 10.5 10.1 10.5 10.4 15.2 11.7 5.7 10.7 7.6 8.9 23.9 11.9 9.6 8.0 12.6 40.0 59.9 27.7 47.5 21.6 27.2 41.7 31.1 34.8 45.0 38.2 74.4 60.2 59.4 68.3 40.1 42.0 53.7 41.6 60.1 28.2 42.0 42.4 97.2 22.5 55.0 40.8 37.6 31.2 29.8 38.0 71.5 53.1 18.7 21.5 55.9 154.6 25.7 35.9 158.4 36.3 72.6 32.1 72.8 36.5 41.9 27.8 59.5 45.3 36.2 31.1 41.4 24.6 38.4 29.3 19.3 64.7 52.3 20.0 33.0 25.5 32.9 36.0 14.2 16.7 36.6 22.7 47.4 40.0 48.5 38.5 4.4 13.6 35.2 17.8 21.4 12.5 15.1 52.8 24.4 19.7 14.7 1.3 11.5 22.2 35.1 14.2 26.6 9.3 10.4 11.5 10.4 9.1 10.0 10.7 10.2 10.6 10.4 10.7 12.6 5.2 9.6 9.0 4.2 12.1 7.9 11.0 26.7 13.6 5.6 14.5 16.8 13.7 18.6 12.8 11.0 27.1 57.8 12.1 12.4 19.6 25.6 1.7 5.8 10.4 6.2 13.2 935.9 3.8 31.2 61.1 9.0 5.6 5.8 2.5 6.3 4.6 23.7 29.1 10.1 5.7 19.1 14.2 13.0 10.4 3.0 5.9 9.5 14.2 1.9 15.3 7.5 8.2 4.5 8.6 23.3 13.0 8.6 25.0 14.5 9.2 24.5 13.6 25.9 0.0 8.6 11.7 1.7 32.0 18.8 8.1 23.3 6.1 16.7 31.0 10.5 HMGCS1 HMGCS ENSG00000112972 "3-hydroxy-3-methylglutaryl-CoA synthase 1" Q01581 5 43287470-43313512 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 390.2" "Cell type enhanced" "Detected in many" "Hepatocytes: 511.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "AF22: 797.7;GAMG: 523.5;HBEC3-KT: 467.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB032907, HPA036913, HPA036914" Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" No No 470000 "Cluster 44: Non-specific - Transcription" "Cluster 85: Liver - Metabolism" "Cluster 12: NES - Nervous system development" "Cluster 15: Hepatocytes - Hemostasis" "Nucleoplasm, Cytosol" "Plasma membrane" "CAB032907: AB_2118319, HPA036913: AB_2675380, HPA036914: AB_10671751" "unprognostic (1.31e-1)" "unprognostic (5.12e-3)" "unprognostic (6.82e-3)" "unprognostic (4.59e-2)" "unprognostic (8.39e-2)" "unprognostic (2.49e-2)" "unprognostic (1.03e-1)" "unprognostic (3.14e-2)" "unprognostic (1.27e-2)" "unprognostic (3.13e-1)" "unprognostic (6.40e-3)" "unprognostic (9.15e-2)" "prognostic favorable (3.87e-6)" "unprognostic (1.09e-1)" "unprognostic (9.22e-2)" "unprognostic (3.03e-2)" "unprognostic (2.37e-2)" 19.2 55.2 25.2 27.2 32.9 15.8 40.1 23.0 38.6 56.4 16.8 50.2 93.6 19.8 36.1 137.5 12.4 23.3 16.1 36.1 44.6 32.8 390.2 51.4 21.5 46.5 34.7 21.6 26.6 31.7 15.0 22.5 47.2 40.5 45.4 34.2 53.2 15.7 17.8 85.9 47.2 19.9 24.7 14.8 43.4 33.2 35.3 19.1 23.6 16.7 31.5 18.3 69.5 30.4 103.4 48.8 797.7 93.0 45.8 178.4 54.1 16.2 63.8 22.8 45.2 86.6 146.6 108.4 35.6 23.3 523.5 80.2 199.7 467.2 24.1 23.5 240.7 40.1 45.3 119.3 71.3 88.0 28.0 98.5 56.2 119.5 47.9 14.0 23.7 98.4 73.1 291.7 19.4 48.9 81.3 111.9 143.1 41.7 25.9 57.5 111.9 121.8 357.7 158.2 68.2 33.0 83.6 41.4 25.9 114.5 63.6 116.7 28.3 17.1 85.7 18.0 15.5 38.8 64.0 148.3 15.0 106.2 15.5 3.3 1.8 1.9 2.4 3.3 2.4 3.8 2.6 3.4 3.5 2.9 2.2 3.1 3.0 3.2 3.6 2.9 2.6 1.6 25.2 32.9 23.0 38.6 36.1 44.6 46.5 34.7 47.2 24.7 35.3 30.4 27.8 67.3 172.6 70.5 44.8 108.3 42.3 93.8 68.3 43.6 46.3 30.0 8.9 47.1 79.2 47.8 52.1 22.3 43.3 211.2 13.7 43.0 9.0 47.1 20.2 31.3 92.1 22.3 44.9 59.8 41.1 32.3 100.4 98.6 58.5 56.6 22.1 511.7 25.5 48.8 42.6 101.9 75.3 21.9 38.2 3.2 12.8 27.5 26.6 15.0 49.1 26.4 14.4 53.3 41.8 50.4 132.3 14.3 38.1 149.2 56.8 21.4 51.1 50.1 0.0 40.1 32.8 20.0 8.7 197.9 236.4 44.5 36.4 129.4 62.9 74.5 HMGCS2 ENSG00000134240 "3-hydroxy-3-methylglutaryl-CoA synthase 2" P54868 1 119748002-119768905 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 7 "liver: 2434.1" "Cell type enhanced" "Detected in many" "Distal enterocytes: 327.2;Hepatocytes: 1118.3;Intestinal goblet cells: 226.8;Paneth cells: 177.7;Undifferentiated cells: 282.3" "Cancer enriched" "Detected in many" 5 "liver cancer: 441.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 12 "OE19: 113.6;RT4: 201.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027423, HPA027442, CAB032906" Enhanced Approved Mitochondria NA NA 830000 "Cluster 85: Liver - Metabolism" "Cluster 21: OE19 - Mitochondria" "Cluster 2: Hepatocytes - Metabolism" Mitochondria "CAB032906: AB_2118322, HPA027423: AB_2672266, HPA027442: AB_2672277" "unprognostic (2.57e-1)" "unprognostic (1.12e-1)" "unprognostic (3.93e-2)" "unprognostic (7.62e-2)" "unprognostic (1.49e-2)" "prognostic favorable (2.43e-7)" "unprognostic (9.68e-2)" "unprognostic (3.21e-2)" "prognostic favorable (2.17e-4)" "unprognostic (1.20e-1)" "unprognostic (6.42e-2)" "prognostic favorable (3.43e-5)" "unprognostic (9.57e-2)" "unprognostic (2.31e-1)" "unprognostic (5.00e-2)" "unprognostic (1.54e-3)" 1.0 0.3 0.0 7.3 0.0 0.0 222.4 0.0 0.0 0.1 5.2 366.7 165.6 1.4 0.4 4.3 0.4 4.3 36.6 0.0 0.1 64.9 2434.1 2.2 0.1 0.0 0.1 0.1 20.1 0.1 0.1 0.4 0.0 34.0 228.0 0.1 50.8 0.6 6.9 14.2 151.8 23.7 0.0 0.6 101.2 35.6 0.0 0.4 0.6 3.1 0.0 36.5 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 12.9 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.1 0.0 0.9 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.2 113.6 0.1 0.2 0.7 0.7 0.0 201.6 0.1 0.8 0.6 0.0 0.0 0.1 7.6 0.0 0.0 0.0 0.5 0.1 0.0 0.2 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 3.2 10.8 0.0 2.4 0.1 3.7 0.0 1.2 0.0 18.8 5.6 8.7 42.9 0.1 31.3 0.0 0.8 0.0 327.2 0.0 0.0 1.9 0.6 0.1 1.1 73.1 24.0 0.0 0.0 0.2 0.2 66.8 1.4 4.5 19.5 16.4 1118.3 0.2 0.0 0.0 226.8 0.0 26.1 0.7 3.9 1.5 0.2 5.4 0.0 0.0 0.0 0.0 0.0 0.1 0.1 177.7 0.0 0.0 6.3 12.4 0.9 0.0 0.0 6.6 0.0 0.1 0.4 0.5 1.9 0.3 9.4 2.2 0.1 282.3 26.5 HNMT ENSG00000150540 "Histamine N-methyltransferase" P50135 2 137964020-138016364 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Methyltransferase, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 245.9" "Cell type enhanced" "Detected in many" "Hofbauer cells: 299.3;Kupffer cells: 263.7;Proximal tubular cells: 268.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 21 "classical monocyte: 110.9;intermediate monocyte: 89.8;myeloid DC: 68.3;non-classical monocyte: 52.2" "Group enriched" "Detected in many" 23 "dendritic cells: 68.3;monocytes: 110.9" "Cell line enhanced" "Detected in many" "Hep G2: 227.2;HSkMC: 87.9;RT4: 117.1;SuSa: 107.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035480, HPA035481, HPA073754" Approved Approved Nucleoplasm,Centrosome,Cytosol NA NA 130000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 85: Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 4: Macrophages - Innate immune response" "Nucleoplasm, Cytosol" Centrosome "HPA035480: AB_2674645, HPA035481: AB_10672094, HPA073754: " "unprognostic (1.32e-1)" "unprognostic (3.53e-1)" "unprognostic (5.44e-2)" "unprognostic (2.09e-2)" "unprognostic (2.81e-1)" "unprognostic (2.33e-1)" "unprognostic (2.29e-2)" "unprognostic (6.02e-2)" "unprognostic (5.69e-2)" "unprognostic (1.43e-1)" "prognostic unfavorable (3.41e-4)" "unprognostic (5.24e-2)" "unprognostic (1.34e-2)" "unprognostic (1.76e-2)" "unprognostic (5.34e-2)" "unprognostic (1.21e-1)" "prognostic favorable (4.68e-4)" 70.4 18.2 13.0 41.7 13.3 12.6 62.3 13.1 18.8 57.3 19.2 53.9 29.3 62.8 27.1 17.5 34.5 68.7 21.7 15.6 19.1 109.7 245.9 49.0 35.1 16.0 15.3 91.0 29.0 40.2 9.5 46.8 18.1 37.0 56.4 6.1 30.5 44.3 5.9 17.4 29.1 33.1 16.1 37.5 29.1 10.3 14.5 8.2 14.6 11.9 16.4 49.7 24.5 22.2 0.7 0.9 5.6 14.6 61.9 64.6 0.4 3.9 6.2 0.4 2.3 29.7 15.7 0.9 50.2 17.0 0.8 1.1 11.9 0.0 0.1 0.7 4.9 0.2 44.5 227.2 28.0 0.3 0.6 87.9 0.1 21.5 0.0 4.7 15.9 0.1 0.5 0.7 47.4 3.7 0.0 0.5 28.1 39.3 5.6 0.5 1.5 0.2 67.9 117.1 0.1 0.8 22.1 28.4 0.1 107.9 1.0 53.2 4.8 4.8 11.8 6.2 16.3 0.4 0.3 0.7 20.9 27.8 3.3 1.3 110.9 0.7 0.5 89.8 0.3 1.8 0.2 0.2 68.3 0.5 0.3 0.4 3.9 0.5 52.2 1.5 0.7 32.6 13.0 13.3 13.1 18.8 15.6 19.1 16.0 15.3 18.1 16.1 14.5 22.2 15.5 28.9 44.1 9.4 5.0 35.6 81.5 64.6 30.7 0.7 78.1 65.4 2.2 133.0 88.9 60.7 0.0 54.9 2.6 59.4 123.3 122.1 1.5 28.3 50.6 9.4 16.4 16.8 16.8 48.0 81.6 54.2 20.9 115.3 0.0 17.4 19.2 165.7 299.3 0.0 13.8 67.8 24.4 263.7 97.2 4.2 131.4 127.4 56.9 31.9 122.0 25.5 4.1 45.8 14.3 71.0 108.6 105.3 0.2 39.8 31.9 268.3 38.4 0.8 78.9 55.2 55.7 0.5 0.9 33.2 25.9 37.6 4.0 43.9 83.5 126.1 HPGDS "GSTS, GSTS1, GSTS1-1, H-PGDS, PGD2, PGDS" ENSG00000163106 "Hematopoietic prostaglandin D synthase" O60760 4 94298535-94342876 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism" "Isomerase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "placenta: 18.7" "Group enriched" "Detected in many" 18 "granulocytes: 1056.2;Hofbauer cells: 631.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 28 "basophil: 18.1" "Lineage enriched" "Detected in single" 28 "granulocytes: 18.1" "Group enriched" "Detected in some" 8 "HEL: 46.2;HMC-1: 13.5" "Low region specificity" "Detected in many" "Not detected" "Not detected" HPA024035 Enhanced Approved Nucleoplasm,Vesicles,Cytosol NA NA 250000 "Cluster 46: Basophils - DNA binding" "Cluster 19: Lung - Lung function" "Cluster 36: HEL - Hemostasis" "Cluster 60: Granulocytes - Receptor signaling" "Vesicles, Cytosol" Nucleoplasm "HPA024035: AB_1855743" "unprognostic (5.71e-2)" "unprognostic (5.80e-3)" "unprognostic (1.17e-1)" "unprognostic (5.36e-3)" "unprognostic (2.76e-1)" "unprognostic (2.38e-4)" "unprognostic (1.01e-2)" "unprognostic (4.41e-3)" "unprognostic (1.35e-1)" "unprognostic (7.75e-4)" "unprognostic (1.44e-1)" "unprognostic (1.14e-1)" "unprognostic (5.15e-3)" "unprognostic (4.07e-2)" "unprognostic (6.48e-2)" "unprognostic (2.61e-2)" "unprognostic (6.14e-2)" 3.4 1.9 2.2 1.1 2.1 1.1 4.0 2.3 3.1 3.5 2.1 5.1 5.8 2.4 2.3 2.9 1.4 6.9 1.8 2.3 2.3 1.5 0.8 9.4 0.6 2.7 2.6 0.5 0.5 0.8 0.4 18.7 2.9 2.6 5.3 0.1 1.5 1.3 0.5 3.3 5.6 3.3 2.6 0.3 2.8 0.7 3.1 2.0 0.3 1.7 0.9 4.8 1.2 3.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 46.2 0.0 0.0 0.0 3.5 13.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 18.1 0.1 0.3 0.0 0.1 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.1 2.2 2.1 2.3 3.1 2.3 2.3 2.7 2.6 2.9 2.6 3.1 3.5 0.3 12.8 44.7 1.0 0.2 4.1 0.8 0.0 0.6 0.0 0.2 0.8 0.3 0.0 3.7 0.0 0.0 3.6 0.7 0.5 0.0 0.5 0.1 0.2 0.0 2.0 7.1 12.2 0.8 0.0 3.0 3.0 3.6 0.0 1056.2 0.0 0.0 0.0 631.9 0.0 0.6 0.0 0.0 11.4 13.1 0.0 0.3 16.3 3.6 32.8 0.1 0.0 0.0 0.0 0.5 0.1 1.2 0.4 2.1 3.9 0.0 0.0 1.5 0.1 0.0 0.6 0.4 0.0 0.1 0.0 5.4 5.5 20.5 0.3 0.9 0.2 HPRT1 "HGPRT, HPRT" ENSG00000165704 "Hypoxanthine phosphoribosyltransferase 1" P00492 X 134460165-134520513 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Purine salvage" "Glycosyltransferase, Transferase" "Disease variant, FDA approved drug targets, Gout" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal tubular cells: 226.9;Spermatocytes: 213.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006360, CAB012200" Enhanced Supported Cytosol NA NA 9400000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 58: Brain - Synaptic function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" Cytosol "CAB012200: AB_297217, HPA006360: AB_1079082" "unprognostic (2.02e-1)" "unprognostic (2.18e-1)" "unprognostic (1.46e-1)" "unprognostic (2.32e-3)" "unprognostic (8.55e-2)" "prognostic unfavorable (1.35e-5)" "unprognostic (1.58e-2)" "unprognostic (4.77e-3)" "unprognostic (4.93e-2)" "unprognostic (2.02e-2)" "unprognostic (7.05e-2)" "unprognostic (1.38e-3)" "unprognostic (6.00e-2)" "unprognostic (2.12e-1)" "unprognostic (2.04e-1)" "unprognostic (2.70e-2)" "unprognostic (1.51e-1)" 15.6 26.2 37.3 24.3 39.4 54.7 20.4 26.0 63.7 13.6 22.9 25.5 20.4 14.0 62.7 20.3 16.9 14.6 24.5 40.3 47.1 45.5 45.8 14.5 32.1 31.2 32.1 16.8 37.1 21.9 31.5 16.3 34.7 15.4 23.5 74.1 13.5 16.0 22.6 14.8 26.5 17.3 24.6 16.9 32.2 76.1 31.4 31.3 22.1 17.8 30.6 25.4 13.9 31.3 138.0 64.9 18.0 37.2 39.4 56.1 54.1 71.6 68.7 89.5 116.8 58.7 85.5 154.4 158.7 46.7 106.8 82.0 117.4 98.2 153.4 129.2 219.3 84.0 85.0 60.2 38.9 182.9 74.0 41.6 36.1 80.1 126.4 49.5 104.9 90.3 65.5 3.8 71.0 141.0 141.9 157.0 37.0 160.7 171.8 83.8 91.1 158.6 109.6 65.7 113.0 61.6 51.7 41.5 50.1 48.8 35.5 75.2 52.4 60.5 45.6 175.0 181.5 56.5 105.1 0.9 74.6 199.5 33.8 5.8 21.9 20.4 20.8 36.5 30.0 24.0 30.4 27.6 37.9 24.8 24.8 26.9 5.6 39.4 35.5 15.7 57.4 25.3 37.3 39.4 26.0 63.7 40.3 47.1 31.2 32.1 34.7 24.6 31.4 31.3 32.1 19.2 8.2 11.1 39.6 39.6 55.7 75.6 18.8 38.3 26.4 22.0 23.8 30.0 29.9 57.0 4.2 17.9 28.1 16.8 226.9 50.1 11.9 30.1 28.3 39.2 27.5 101.8 55.3 32.3 30.5 29.5 30.1 41.8 34.9 29.0 20.7 22.2 71.2 25.2 43.1 30.4 63.1 60.7 81.7 32.2 40.7 56.2 55.2 10.3 122.5 37.2 26.8 22.1 30.7 36.6 28.2 26.7 30.9 78.1 24.1 30.2 28.9 78.0 52.6 31.6 39.4 213.5 172.6 40.4 38.8 6.0 53.8 30.2 51.3 46.8 HS3ST1 3OST1 ENSG00000002587 "Heparan sulfate-glucosamine 3-sulfotransferase 1" O14792 4 11393150-11429564 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 25.4;ovary: 31.9" "Cell type enhanced" "Detected in many" "Club cells: 112.0;granulocytes: 96.3;Granulosa cells: 285.0;Peritubular cells: 90.3;Urothelial cells: 92.9" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in all" "cerebellum: 25.4" "Group enriched" "Detected in some" 36 "memory B-cell: 14.9;naive B-cell: 26.6;plasmacytoid DC: 42.3" "Group enriched" "Detected in many" 108 "B-cells: 26.6;dendritic cells: 42.3" "Cell line enhanced" "Detected in some" "A-431: 5.8;CAPAN-2: 20.6;HaCaT: 6.0;RPTEC TERT1: 13.2;RT4: 14.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA002237 Approved Approved Vesicles "Intracellular and membrane" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 21: Non-specific - Transcription" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 40: Granulosa cells - Unknown function" Vesicles "HPA002237: AB_1079085" "unprognostic (1.10e-1)" "unprognostic (2.66e-1)" "unprognostic (4.01e-2)" "prognostic favorable (7.73e-4)" "unprognostic (3.32e-2)" "unprognostic (8.90e-3)" "unprognostic (4.21e-1)" "unprognostic (2.08e-1)" "unprognostic (2.22e-1)" "unprognostic (1.32e-1)" "unprognostic (1.77e-2)" "unprognostic (1.08e-1)" "prognostic favorable (5.99e-8)" "unprognostic (9.99e-2)" "unprognostic (1.42e-1)" "unprognostic (1.57e-1)" "prognostic favorable (8.67e-4)" 2.6 2.5 2.3 2.7 1.9 2.0 1.9 25.4 6.9 2.4 0.0 2.1 3.7 3.4 1.3 11.6 4.4 12.7 1.9 1.6 4.7 5.9 0.4 1.8 2.3 4.7 3.3 31.9 1.0 0.1 4.7 0.7 3.8 2.0 1.1 1.0 5.6 1.5 0.4 0.5 2.9 0.9 4.4 3.3 6.5 1.3 5.8 1.3 1.6 0.2 1.2 14.5 2.6 6.1 5.8 1.8 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 20.6 0.0 0.4 0.0 0.0 6.0 0.0 2.8 0.0 0.3 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.8 0.3 0.0 0.0 0.7 0.0 0.0 0.0 0.0 1.1 1.6 2.2 1.2 0.0 0.0 13.2 14.5 4.6 0.0 0.0 0.1 0.4 0.2 0.0 0.0 2.0 0.7 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.3 0.2 14.9 0.0 0.0 0.7 26.6 0.0 0.0 0.0 0.0 0.0 42.3 0.0 1.1 2.3 1.9 25.4 6.9 1.6 4.7 4.7 3.3 3.8 4.4 5.8 6.1 3.5 3.2 5.8 0.0 13.1 9.1 13.5 70.1 5.2 3.7 2.4 9.3 3.2 32.9 112.0 20.2 4.2 0.5 21.6 5.2 0.0 25.0 1.7 3.6 1.0 28.9 2.4 0.0 13.4 2.1 42.1 13.2 23.9 14.9 96.3 285.0 25.0 0.4 37.6 1.7 35.0 7.2 71.2 3.5 3.7 2.0 8.7 12.5 1.8 6.5 4.9 32.9 8.2 24.1 0.7 51.9 6.5 90.3 0.0 5.6 2.7 19.1 61.2 2.6 0.0 0.5 17.5 5.4 5.6 36.6 8.1 1.4 1.4 68.5 4.3 92.9 HS3ST2 3OST2 ENSG00000122254 "Heparan sulfate-glucosamine 3-sulfotransferase 2" Q9Y278 16 22814162-22916338 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 6 "brain: 29.9" "Cell type enhanced" "Detected in some" "Excitatory neurons: 99.8;Hofbauer cells: 16.9;Inhibitory neurons: 25.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 6 "HaCaT: 9.7;SH-SY5Y: 16.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA017736 Approved NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA017736: AB_1851095" "unprognostic (4.09e-2)" "unprognostic (2.90e-3)" "unprognostic (5.97e-3)" "unprognostic (3.46e-3)" "prognostic unfavorable (1.57e-4)" "unprognostic (2.00e-1)" "unprognostic (1.05e-1)" "unprognostic (2.17e-3)" "unprognostic (1.83e-1)" "unprognostic (2.75e-2)" "unprognostic (1.95e-1)" "unprognostic (2.45e-1)" "prognostic favorable (1.35e-4)" "unprognostic (4.89e-2)" "unprognostic (1.16e-1)" "unprognostic (1.35e-1)" "unprognostic (3.00e-2)" 3.0 1.2 11.5 0.0 16.8 0.0 2.1 0.8 29.9 1.8 0.5 0.7 0.0 0.7 0.0 0.2 0.6 0.0 1.0 11.7 6.2 0.4 0.6 5.4 0.0 3.9 6.6 0.3 0.2 0.0 0.3 0.1 5.2 1.9 0.2 0.4 3.1 0.0 0.4 2.0 0.5 0.1 2.4 0.3 0.7 0.3 2.6 0.0 1.8 0.1 0.0 1.1 1.1 16.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 9.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 16.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.5 16.8 0.8 29.9 11.7 6.2 3.9 6.6 5.2 2.4 2.6 16.3 0.8 0.0 0.0 1.6 0.0 3.6 0.2 0.0 0.0 10.3 0.1 0.1 0.9 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 1.6 0.1 0.0 0.0 2.3 0.0 0.0 99.8 0.0 0.2 1.9 0.0 0.2 0.0 0.0 0.4 0.2 16.9 0.0 25.7 0.0 0.0 1.0 2.7 1.5 1.2 7.3 0.0 0.0 0.0 0.0 0.0 3.5 1.8 0.9 0.0 5.7 0.0 1.1 0.0 0.0 0.0 0.7 0.0 0.3 5.8 0.1 0.0 0.0 2.0 0.3 0.1 0.0 0.0 0.8 HS3ST3A1 "30ST3A1, 3OST3A1" ENSG00000153976 "Heparan sulfate-glucosamine 3-sulfotransferase 3A1" Q9Y663 17 13494032-13601929 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "ovary: 8.1" "Cell type enhanced" "Detected in some" "Astrocytes: 9.8;Granulosa cells: 11.6;Hepatic stellate cells: 7.1;Horizontal cells: 26.9;Leydig cells: 13.7;Squamous epithelial cells: 9.3" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in many" "medulla oblongata: 5.9" "Immune cell enhanced" "Detected in some" "T-reg: 2.2" "Group enriched" "Detected in many" 5 "dendritic cells: 1.7;T-cells: 2.2" "Group enriched" "Detected in many" 4 "PC-3: 40.9;U-251 MG: 123.0;U-87 MG: 73.2" "Region enhanced" "Detected in many" "olfactory bulb: 5.0" "Region enhanced" "Detected in some" "olfactory bulb: 5.3" "HPA062518, HPA071530" Uncertain Approved Microtubules NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 64: Macrophages - Immune response" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 40: Granulosa cells - Unknown function" Microtubules "HPA062518: AB_2684789, HPA071530: AB_2686411" "unprognostic (2.88e-3)" "unprognostic (4.21e-2)" "unprognostic (8.35e-2)" "unprognostic (3.50e-2)" "unprognostic (1.48e-3)" "unprognostic (4.44e-2)" "unprognostic (2.01e-1)" "unprognostic (4.46e-3)" "unprognostic (2.12e-4)" "unprognostic (1.12e-2)" "unprognostic (8.52e-2)" "unprognostic (1.55e-1)" "unprognostic (1.85e-9)" "unprognostic (1.83e-2)" "unprognostic (1.21e-1)" "unprognostic (1.33e-3)" "unprognostic (4.70e-3)" 0.4 2.0 0.1 1.9 1.0 1.0 0.4 0.0 0.6 4.5 3.2 1.2 1.4 0.7 0.1 4.6 1.3 0.3 2.5 0.2 0.0 1.4 1.9 1.2 2.6 5.9 1.4 8.1 0.3 0.0 0.7 2.7 1.1 3.1 0.3 1.3 2.0 4.9 0.1 0.7 1.2 0.2 3.5 6.4 0.6 2.3 0.1 0.3 0.3 0.0 1.6 0.5 3.4 0.5 0.1 0.3 3.3 0.0 2.7 6.8 5.1 18.2 4.4 3.2 2.0 0.0 0.6 0.0 2.6 11.2 0.0 0.0 0.1 0.0 3.1 1.1 18.3 4.9 1.5 2.0 1.6 0.0 1.2 4.9 0.1 8.5 2.2 5.5 0.0 0.2 19.2 0.0 3.8 2.5 0.1 3.3 3.5 0.0 40.9 0.6 0.0 0.0 0.0 0.0 0.0 0.6 0.2 0.0 0.1 2.0 0.1 0.6 0.2 3.1 0.4 0.1 123.0 0.0 0.0 0.0 73.2 0.0 9.1 0.0 0.0 0.0 0.7 0.0 0.3 0.0 0.4 0.5 0.0 0.0 0.5 0.5 0.2 0.3 0.0 1.7 2.2 0.3 0.1 1.0 0.0 0.6 0.2 0.0 5.9 1.4 1.1 3.5 0.1 0.5 0.2 0.0 0.0 9.8 0.0 0.6 0.0 0.0 5.7 0.3 0.0 0.3 0.8 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.2 0.8 0.4 0.3 1.1 0.0 0.0 1.8 0.2 0.0 4.7 0.0 0.2 0.0 11.6 7.1 0.0 1.6 26.9 4.1 0.0 0.0 0.8 0.3 0.1 13.7 0.0 0.0 1.9 0.0 2.4 0.0 0.5 0.2 0.7 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 2.8 4.0 0.3 0.4 9.3 0.6 0.1 0.1 0.0 0.0 0.0 HS3ST3B1 "30ST3B1, 3OST3B1" ENSG00000125430 "Heparan sulfate-glucosamine 3-sulfotransferase 3B1" Q9Y662 17 14301081-14349404 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 28.4;retina: 11.5" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 39.6;dendritic cells: 32.5;Hepatic stellate cells: 25.7;Hepatocytes: 39.7;Syncytiotrophoblasts: 36.3" "Cancer enhanced" "Detected in many" "liver cancer: 5.3" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in many" "plasmacytoid DC: 35.1" "Group enriched" "Detected in many" 5 "dendritic cells: 35.1;T-cells: 26.2" "Cell line enhanced" "Detected in many" "AF22: 20.7;BEWO: 14.9;Hep G2: 18.8;HSkMC: 20.2;U-251 MG: 19.9" "Low region specificity" "Detected in many" "Low region specificity" "Detected in single" HPA064126 Approved Vesicles NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 28: BEWO - Transcription regulation" "Cluster 65: Plasmacytoid DCs - Unknown function" Vesicles "HPA064126: AB_2685194" "unprognostic (1.74e-1)" "unprognostic (1.13e-1)" "unprognostic (2.29e-2)" "unprognostic (5.55e-3)" "unprognostic (2.85e-3)" "unprognostic (5.22e-2)" "unprognostic (5.03e-3)" "unprognostic (1.79e-1)" "unprognostic (2.93e-1)" "unprognostic (8.13e-3)" "unprognostic (8.80e-2)" "unprognostic (1.13e-1)" "unprognostic (1.02e-3)" "unprognostic (7.77e-3)" "unprognostic (9.46e-2)" "unprognostic (1.91e-1)" "unprognostic (1.54e-3)" 0.9 0.9 0.2 4.6 1.0 1.4 0.9 0.3 1.3 2.4 1.5 1.2 1.3 0.6 0.2 1.8 0.9 1.4 1.5 0.4 0.4 3.0 28.4 1.6 6.3 5.4 2.5 3.5 0.6 0.3 0.7 3.5 2.0 2.0 1.7 11.5 5.3 2.0 1.0 1.5 1.8 0.5 2.9 3.4 1.2 0.4 1.4 3.2 0.7 0.9 4.8 2.6 1.9 0.9 0.0 0.4 20.7 0.0 6.2 6.9 14.9 6.1 8.7 5.3 5.6 0.0 0.1 0.0 0.0 8.2 0.0 0.1 0.5 3.3 2.7 1.8 4.5 0.5 2.9 18.8 8.1 0.8 3.2 20.2 1.1 1.9 4.8 1.2 0.0 1.1 6.6 0.1 4.3 1.1 1.0 0.8 0.7 0.1 0.6 3.9 0.7 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 2.8 0.4 0.6 0.0 5.2 0.0 0.1 19.9 0.0 0.0 0.0 4.0 0.0 1.2 0.2 0.4 0.0 10.2 0.7 8.1 0.9 12.0 8.0 0.8 0.7 12.1 11.8 0.9 6.6 0.8 35.1 26.2 5.1 0.2 1.0 0.3 1.3 0.4 0.4 5.4 2.5 2.0 2.9 1.4 0.9 2.9 0.0 1.1 6.2 3.5 11.5 0.3 4.9 21.1 3.2 1.2 2.2 3.0 10.0 3.9 7.3 39.6 7.2 32.5 0.0 0.0 0.7 14.3 0.3 1.5 2.9 0.0 0.4 3.3 0.2 11.9 6.6 0.0 0.8 0.0 2.4 25.7 39.7 1.6 8.4 2.2 0.1 2.0 3.8 12.9 3.3 2.8 6.7 1.8 1.9 1.3 7.3 14.4 3.5 0.1 0.2 0.0 1.2 2.2 1.1 0.4 0.1 3.9 17.9 13.1 15.0 2.6 4.0 0.3 10.0 14.8 36.3 12.4 0.1 0.2 0.3 HS3ST4 3OST4 ENSG00000182601 "Heparan sulfate-glucosamine 3-sulfotransferase 4" Q9Y661 16 25691959-26137685 "Enzymes, Metabolic proteins, Predicted membrane proteins" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 10 "brain: 38.1" "Group enriched" "Detected in some" 9 "Excitatory neurons: 431.4;Microglial cells: 536.8" "Cancer enhanced" "Detected in some" "prostate cancer: 1.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "NTERA-2: 1.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" NA NA "Cluster 65: Brain - Ion transport" "Cluster 5: NTERA-2 - Transcription" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "unprognostic (1.09e-2)" "unprognostic (1.87e-1)" "unprognostic (2.95e-1)" "unprognostic (2.24e-1)" "unprognostic (1.43e-3)" "unprognostic (1.27e-1)" "unprognostic (3.84e-1)" "unprognostic (8.81e-3)" "unprognostic (6.71e-2)" "unprognostic (2.39e-1)" "unprognostic (1.92e-1)" "unprognostic (2.51e-2)" "unprognostic (3.67e-2)" 0.0 0.0 19.0 0.0 17.5 0.0 2.2 7.0 15.8 0.3 3.3 0.0 0.0 0.0 0.3 0.4 0.0 0.0 0.0 33.2 12.2 0.0 0.0 0.0 0.0 18.2 11.8 0.0 0.0 3.6 0.3 0.0 19.0 0.8 0.0 2.0 0.1 0.0 0.0 0.5 0.0 0.0 7.5 1.6 1.7 0.5 38.1 0.2 0.0 0.0 0.0 0.2 0.5 18.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.0 17.5 7.0 15.8 33.2 12.2 18.2 11.8 19.0 7.5 38.1 18.5 0.0 0.0 0.0 7.5 0.1 0.0 0.4 0.1 0.0 26.0 2.6 2.7 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.0 431.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 48.9 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 536.8 0.0 0.4 0.0 6.6 9.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.2 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.2 HS3ST5 3-OST-5 ENSG00000249853 "Heparan sulfate-glucosamine 3-sulfotransferase 5" Q8IZT8 6 114055586-114343045 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 9.7;skeletal muscle: 3.2" "Cell type enhanced" "Detected in some" "Astrocytes: 102.5;Excitatory neurons: 154.8;Inhibitory neurons: 130.9;Oligodendrocytes: 606.0" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "PC-3: 4.6;RT4: 6.8;SCLC-21H: 14.2;U-266/70: 4.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA021823, HPA064677" Approved NA NA "Cluster 70: Brain - Nervous system development" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "HPA021823: AB_1851100, HPA064677: AB_2685318" "unprognostic (1.19e-1)" "unprognostic (2.63e-2)" "unprognostic (2.81e-2)" "unprognostic (1.04e-2)" "unprognostic (1.72e-2)" "unprognostic (3.00e-2)" "unprognostic (7.98e-4)" "unprognostic (5.39e-2)" "unprognostic (6.29e-2)" "unprognostic (1.61e-1)" "unprognostic (1.91e-1)" "unprognostic (5.72e-2)" "unprognostic (3.28e-2)" "unprognostic (3.01e-1)" "unprognostic (3.48e-1)" "unprognostic (1.53e-2)" 0.0 0.3 3.5 0.1 9.7 0.2 0.0 3.6 4.4 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 2.8 4.5 0.1 0.0 0.1 0.0 7.2 7.0 0.0 0.2 0.0 0.0 0.0 7.3 0.0 0.1 1.1 0.0 1.3 3.2 0.2 0.1 0.1 6.5 0.0 0.2 0.1 7.6 0.0 0.0 1.4 0.0 2.2 0.0 6.0 0.1 0.0 2.5 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.7 1.9 4.6 0.0 0.8 0.0 0.0 6.8 14.2 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.6 0.0 0.1 4.1 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.5 9.7 3.6 4.4 2.8 4.5 7.2 7.0 7.3 6.5 7.6 6.0 0.0 0.0 0.0 102.5 0.0 1.3 0.0 0.0 0.0 3.8 0.0 0.0 0.6 0.0 0.0 11.0 18.8 0.0 0.0 0.0 0.0 0.0 2.8 0.1 0.0 0.1 0.0 0.0 154.8 0.2 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 130.9 0.4 0.0 0.0 0.0 0.8 3.7 0.0 0.0 9.4 0.0 0.0 0.0 11.6 606.0 0.9 0.0 0.0 0.0 0.0 0.0 0.2 0.0 1.8 0.0 7.9 0.1 1.3 0.7 0.0 0.0 0.1 0.0 0.0 0.0 0.5 HS3ST6 HS3ST5 ENSG00000162040 "Heparan sulfate-glucosamine 3-sulfotransferase 6" Q96QI5 16 1911475-1918415 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "skin 1: 75.7" "Cell type enhanced" "Detected in some" "Endometrial ciliated cells: 10.7;Horizontal cells: 21.9;Suprabasal keratinocytes: 9.1;Urothelial cells: 24.9" "Cancer enhanced" "Detected in many" "urothelial cancer: 4.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "A549: 1.1" "Not detected" "Not detected" "Low region specificity" "Detected in all" NA NA "Cluster 31: Skin - Epidermis development" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 22: Epithelial cell types - Mixed function" "unprognostic (5.72e-2)" "prognostic favorable (3.73e-4)" "unprognostic (1.30e-1)" "unprognostic (1.20e-2)" "unprognostic (1.19e-2)" "unprognostic (3.10e-1)" "unprognostic (4.99e-3)" "unprognostic (2.10e-2)" "unprognostic (6.55e-3)" "unprognostic (2.42e-1)" "unprognostic (3.61e-1)" "unprognostic (2.26e-1)" 0.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 8.6 0.0 0.5 0.0 0.0 0.0 14.4 0.7 0.0 0.0 0.0 0.0 0.8 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.8 0.0 1.4 0.0 0.0 1.9 0.0 0.3 75.7 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.1 0.0 0.0 0.1 4.1 10.8 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 1.5 3.4 0.9 0.0 0.0 0.1 0.0 0.3 0.0 0.7 1.8 0.0 0.2 0.0 6.3 0.0 0.0 4.5 10.7 0.5 0.1 0.0 0.0 0.1 0.0 0.4 2.0 0.0 1.4 0.0 0.0 0.0 0.0 0.2 21.9 0.1 0.9 4.1 0.0 1.5 1.4 0.0 0.1 3.6 0.0 0.0 0.0 0.0 0.0 0.2 0.0 2.8 0.0 0.0 2.7 0.2 0.2 5.0 0.2 0.0 0.0 0.3 0.0 0.0 4.5 9.1 0.1 0.1 0.0 1.7 24.9 HUNK ENSG00000142149 "Hormonally up-regulated Neu-associated kinase" P57058 21 31873020-32044633 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "pancreas: 9.8" "Cell type enriched" "Detected in many" 5 "Inhibitory neurons: 109.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 13.2;BEWO: 16.3;RH-30: 18.1;SCLC-21H: 14.8;SiHa: 13.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA027295, HPA027372" Approved Approved "Nucleoplasm,Plasma membrane" NA NA "Cluster 29: Non-specific - Vesicular transport" "Cluster 28: BEWO - Transcription regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Plasma membrane" "HPA027295: AB_2672203, HPA027372: AB_2672239" "unprognostic (9.09e-3)" "unprognostic (7.29e-2)" "unprognostic (1.42e-1)" "unprognostic (5.95e-3)" "unprognostic (1.99e-1)" "unprognostic (2.12e-4)" "unprognostic (4.00e-2)" "unprognostic (6.90e-2)" "unprognostic (5.07e-1)" "unprognostic (2.27e-1)" "unprognostic (9.09e-2)" "unprognostic (1.13e-1)" "prognostic favorable (7.48e-5)" "unprognostic (8.84e-2)" "unprognostic (2.22e-1)" "unprognostic (1.39e-1)" "unprognostic (6.69e-2)" 0.7 1.0 0.8 1.3 1.3 0.2 1.2 0.4 4.7 0.4 0.0 3.6 1.4 4.1 1.9 0.4 1.9 0.5 0.4 4.2 2.6 3.7 0.5 0.9 0.4 0.4 0.1 0.6 9.8 0.1 1.1 4.6 0.1 0.9 3.7 3.0 0.6 2.1 0.3 3.0 2.7 2.4 0.0 0.1 1.3 0.9 0.2 0.7 0.6 0.2 0.6 1.5 0.7 1.6 0.0 3.9 13.2 0.1 0.0 0.0 16.3 1.3 0.0 0.2 0.0 5.3 0.1 0.0 0.5 6.2 0.2 0.0 7.7 0.0 0.1 0.1 3.9 0.0 3.7 2.6 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 4.7 0.0 0.0 0.0 1.1 0.2 1.1 10.2 0.1 0.1 0.1 18.1 0.1 1.3 0.0 14.8 9.8 13.2 1.0 0.5 9.3 5.5 1.4 0.0 0.1 9.3 0.1 0.0 0.1 0.0 1.8 0.0 0.0 6.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.8 1.3 0.4 4.7 4.2 2.6 0.4 0.1 0.1 0.0 0.2 1.6 0.2 6.4 9.1 7.5 0.0 5.1 2.6 0.2 0.6 8.1 0.5 2.8 3.5 14.3 3.0 7.3 2.1 9.2 0.0 4.6 0.0 5.3 0.2 1.2 1.3 0.8 4.9 0.0 19.0 3.3 13.9 7.9 0.5 3.4 0.0 4.3 0.4 1.0 2.7 3.3 109.6 5.1 0.0 0.0 4.2 0.1 0.3 0.4 3.6 1.0 0.1 8.1 0.0 10.1 1.5 1.6 4.4 0.0 0.0 2.1 1.8 1.9 0.8 1.2 0.0 6.3 2.2 0.7 1.1 0.7 5.8 6.2 0.5 0.0 10.6 0.9 HUWE1 "Ib772, KIAA0312, UREB1" ENSG00000086758 "HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1" Q7Z6Z7 X 53532096-53686728 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Biological rhythms, Differentiation, DNA damage, DNA repair, Ubl conjugation pathway" "DNA-binding, Transferase" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in all" 4 "Granulosa cells: 507.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002548, CAB022718" Approved Enhanced Nucleoplasm,Cytosol NA NA 73000 "Cluster 27: Non-specific - Gene expression" "Cluster 80: Striated muscle - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 40: Granulosa cells - Unknown function" "Nucleoplasm, Cytosol" "CAB022718: , HPA002548: AB_1080489" "unprognostic (4.73e-2)" "unprognostic (9.06e-2)" "unprognostic (1.31e-1)" "unprognostic (1.59e-2)" "unprognostic (6.64e-2)" "unprognostic (3.16e-2)" "unprognostic (1.33e-2)" "unprognostic (2.21e-1)" "unprognostic (3.56e-1)" "unprognostic (5.51e-2)" "unprognostic (1.33e-1)" "unprognostic (8.89e-2)" "unprognostic (8.10e-3)" "unprognostic (2.17e-1)" "unprognostic (1.32e-1)" "unprognostic (3.67e-2)" "unprognostic (2.45e-1)" 37.7 46.1 55.6 21.1 57.4 26.7 37.4 57.6 69.6 39.8 42.0 49.4 17.6 45.6 52.6 48.4 40.7 18.5 57.1 62.6 61.3 45.2 41.8 36.1 26.6 58.7 67.8 54.0 45.9 43.2 54.2 24.0 73.2 38.4 22.7 40.0 38.9 28.6 101.0 59.3 40.2 28.8 49.1 42.5 45.5 43.0 65.1 41.2 42.9 58.1 30.3 44.6 40.2 57.2 166.8 100.4 64.0 45.4 109.2 64.8 78.5 48.8 62.6 50.2 52.3 77.0 52.2 86.6 32.3 89.4 90.4 77.8 145.6 81.8 68.3 125.6 64.6 69.1 91.9 60.5 100.2 104.5 40.6 62.4 59.8 120.8 137.6 49.7 88.3 66.4 70.3 54.5 66.3 102.4 57.0 58.2 87.7 45.4 71.3 52.0 87.9 52.8 84.0 113.3 53.1 38.4 137.7 60.5 44.1 118.7 87.0 50.1 113.8 46.0 65.8 66.5 62.9 47.3 50.2 73.1 49.2 100.1 67.6 2.8 2.3 4.3 3.3 1.9 4.0 2.4 3.1 3.5 3.3 2.4 2.2 2.2 1.9 3.5 3.8 3.5 2.9 1.9 55.6 57.4 57.6 69.6 62.6 61.3 58.7 67.8 73.2 49.1 65.1 57.2 41.4 51.3 46.1 70.2 41.9 30.1 32.6 30.4 44.9 57.8 37.0 35.6 110.4 37.1 35.4 40.5 50.1 31.0 40.0 29.2 1.9 42.8 28.6 45.6 59.8 38.3 47.6 47.7 94.4 35.4 34.8 38.6 57.1 69.6 22.1 507.7 32.9 48.1 24.8 82.4 85.8 28.1 18.3 31.4 30.8 32.8 28.3 34.1 26.6 59.0 43.7 22.6 35.0 83.9 95.3 49.3 20.5 39.1 50.9 44.1 27.1 14.7 35.7 33.3 13.1 69.6 56.4 34.5 44.6 53.3 41.6 37.9 46.7 114.1 31.7 42.0 HYKK "AGPHD1, LOC123688" ENSG00000188266 "Hydroxylysine kinase" A2RU49 15 78507564-78537372 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal tubular cells: 29.4;Late spermatids: 33.7;Proximal enterocytes: 37.0;Proximal tubular cells: 39.4;Skeletal myocytes: 28.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "naive CD4 T-cell: 3.0" "Lineage enriched" "Detected in single" 6 "T-cells: 3.0" "Cell line enhanced" "Detected in many" "HEK 293: 22.2;U-266/84: 24.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA040706 Approved Approved Vesicles,Aggresome NA NA "Cluster 32: T-cells - Unknown function" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Vesicles Aggresome "HPA040706: AB_10795528" "unprognostic (9.26e-2)" "unprognostic (1.98e-4)" "unprognostic (7.84e-2)" "unprognostic (3.16e-2)" "unprognostic (3.64e-1)" "unprognostic (2.72e-2)" "unprognostic (1.14e-1)" "unprognostic (8.00e-3)" "unprognostic (2.73e-1)" "unprognostic (5.16e-2)" "unprognostic (6.24e-3)" "unprognostic (6.37e-2)" "unprognostic (3.44e-3)" "unprognostic (2.19e-1)" "unprognostic (1.04e-1)" "unprognostic (3.11e-3)" "unprognostic (3.90e-2)" 4.5 4.8 2.8 1.0 3.1 1.3 4.5 2.2 3.2 5.6 1.6 4.6 7.3 3.8 5.9 2.8 4.3 2.4 5.3 2.7 2.2 12.3 5.7 2.1 2.0 2.0 2.0 6.1 6.8 4.8 3.5 0.7 1.8 4.1 3.4 2.6 3.5 4.1 6.2 2.8 7.2 3.6 1.6 1.3 5.1 5.3 2.3 1.9 4.5 5.4 1.7 3.9 3.8 2.9 4.3 6.3 1.0 11.3 2.3 5.3 2.7 1.5 2.7 3.7 4.2 2.2 4.9 3.1 1.4 2.5 6.3 5.2 10.0 3.3 3.5 1.5 22.2 1.7 3.8 5.6 6.0 0.5 1.9 4.8 6.4 1.4 2.7 1.8 2.7 13.8 4.0 8.4 2.2 5.0 4.2 1.0 0.7 9.8 8.3 2.4 12.4 2.7 7.1 5.1 1.3 1.6 2.9 8.6 10.9 1.9 9.5 0.4 1.9 2.4 1.8 4.3 4.4 12.9 24.2 0.2 3.2 0.2 3.4 0.4 0.1 0.2 0.1 0.0 0.1 0.1 1.1 0.1 0.0 0.1 3.0 0.6 0.3 0.1 0.0 0.3 0.5 0.4 2.8 3.1 2.2 3.2 2.7 2.2 2.0 2.0 1.8 1.6 2.3 2.9 4.1 12.8 4.1 4.6 1.4 3.6 7.7 4.5 6.2 2.0 4.5 9.8 6.7 0.0 2.9 7.3 2.1 7.3 1.5 2.8 29.4 2.5 14.0 2.7 3.3 4.1 4.2 1.3 2.8 7.9 4.4 5.4 5.1 1.5 0.0 2.4 6.8 7.1 0.8 0.0 2.7 3.9 2.0 1.0 0.9 33.7 5.3 1.0 7.2 2.8 0.3 7.5 0.0 0.5 1.1 2.9 3.6 3.8 1.7 3.7 37.0 39.4 3.5 1.9 0.0 28.1 4.0 5.4 8.0 4.9 1.6 3.4 1.6 3.9 5.7 4.7 ICMT "HSTE14, PCCMT, PPMT" ENSG00000116237 "Isoprenylcysteine carboxyl methyltransferase" O60725 1 6221193-6235972 "Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Extravillous trophoblasts: 85.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Region enriched" "Detected in all" 5 "cerebellum: 112.8" "Low region specificity" "Detected in all" "HPA032024, HPA032025" Uncertain NA NA "Cluster 44: Non-specific - Transcription" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 38: Extravillous trophoblasts - Unknown function" "HPA032024: AB_2674115, HPA032025: AB_10601819" "unprognostic (1.95e-3)" "unprognostic (3.83e-2)" "unprognostic (7.34e-2)" "unprognostic (4.40e-2)" "unprognostic (5.53e-2)" "unprognostic (9.30e-2)" "prognostic unfavorable (1.79e-4)" "unprognostic (2.30e-2)" "unprognostic (7.05e-2)" "unprognostic (2.15e-1)" "unprognostic (1.87e-1)" "unprognostic (6.58e-2)" "unprognostic (2.11e-2)" "unprognostic (4.11e-1)" "unprognostic (5.27e-1)" "unprognostic (8.97e-2)" "unprognostic (1.99e-3)" 22.6 23.0 12.4 13.6 18.1 4.0 15.8 18.2 13.1 20.3 17.7 20.9 19.6 20.1 20.9 21.6 16.2 13.1 27.1 12.5 12.9 25.9 13.6 14.9 10.2 12.6 14.9 9.1 17.4 26.8 22.0 21.0 12.7 17.3 17.4 28.7 17.1 18.9 53.0 19.2 18.3 21.9 12.3 9.1 15.7 5.2 14.5 14.9 18.1 82.6 11.0 17.4 16.0 12.0 35.8 32.6 43.7 43.0 131.2 51.8 18.7 84.9 56.1 48.7 36.9 35.0 28.2 39.0 31.7 66.7 42.0 47.4 50.5 35.6 51.5 78.8 51.3 26.8 46.0 26.8 25.5 42.5 36.4 33.3 23.5 51.2 19.2 32.4 38.5 31.6 26.5 29.8 55.7 22.3 43.2 29.6 29.7 64.1 46.0 35.8 61.5 22.6 59.3 25.8 59.2 28.8 41.3 96.3 37.2 48.4 25.2 35.4 48.1 55.3 21.7 65.4 61.6 27.7 57.8 30.5 27.1 96.5 29.3 2.6 1.9 1.6 3.1 2.2 2.7 1.1 2.5 3.1 1.7 1.8 2.1 1.8 0.6 1.8 1.9 2.7 1.4 1.9 12.4 18.1 18.2 13.1 12.5 12.9 12.6 14.9 12.7 12.3 14.5 12.0 18.0 22.4 12.1 5.9 7.7 6.2 9.6 12.2 7.4 18.0 16.3 9.8 39.3 15.7 19.6 29.5 31.3 57.6 12.3 40.7 13.7 21.9 3.5 19.5 18.8 18.1 22.8 14.9 10.2 22.2 85.7 19.6 12.8 16.9 5.1 13.9 21.8 23.9 29.1 48.8 9.4 21.4 12.2 12.0 7.0 5.1 20.8 9.8 7.2 7.5 12.1 18.9 10.3 2.0 5.4 26.8 12.2 26.4 18.3 14.1 45.5 36.9 41.7 58.8 13.1 9.9 22.1 15.4 26.8 28.2 10.4 32.0 10.4 13.9 23.1 14.7 IDNK "bA522I20.2, C9orf103, hGntK" ENSG00000148057 "IDNK gluconokinase" Q5T6J7 9 83623049-83644130 "Enzymes, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 70.5" "Cell type enhanced" "Detected in many" "Distal tubular cells: 80.3;Proximal enterocytes: 84.2;Proximal tubular cells: 224.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "MCF7: 26.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020378, HPA058429" Approved Approved Mitochondria,Cytosol NA NA "Cluster 35: T-regs - Unknown function" "Cluster 7: Kidney - Transmembrane transport" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Mitochondria, Cytosol" "HPA020378: AB_1845794, HPA058429: AB_2683716" "unprognostic (1.49e-3)" "unprognostic (7.94e-2)" "unprognostic (3.30e-1)" "prognostic favorable (1.10e-6)" "unprognostic (1.39e-1)" "unprognostic (1.56e-1)" "unprognostic (5.41e-3)" "unprognostic (1.81e-2)" "unprognostic (6.08e-2)" "unprognostic (1.57e-1)" "unprognostic (2.61e-2)" "unprognostic (3.00e-1)" "unprognostic (5.86e-3)" "unprognostic (7.32e-2)" "unprognostic (1.07e-1)" "unprognostic (2.55e-1)" "unprognostic (3.11e-2)" 8.9 12.0 18.8 6.1 24.5 5.8 8.7 20.6 26.8 4.3 22.7 9.5 26.3 5.3 13.3 8.3 12.9 6.4 5.8 19.1 22.6 50.9 70.5 7.3 11.0 20.3 20.8 5.5 13.8 14.8 9.0 3.0 20.6 8.4 9.2 10.9 8.8 9.5 2.3 7.1 26.9 4.4 20.5 7.9 8.9 3.7 20.8 38.9 13.2 2.6 9.5 5.2 3.9 21.1 4.3 10.4 1.7 1.8 4.6 6.9 7.8 3.4 8.6 3.5 2.8 2.9 5.3 5.8 5.2 5.8 3.5 8.4 1.3 2.0 3.6 11.9 1.6 2.1 4.6 12.7 19.4 1.5 2.8 4.3 3.3 7.2 7.2 6.2 7.9 16.0 1.9 7.1 4.8 26.8 3.7 1.4 1.6 18.1 6.0 4.6 4.2 3.3 9.6 5.5 6.9 8.6 7.5 6.5 7.6 2.5 6.0 8.1 7.4 1.6 1.3 14.3 6.1 9.0 10.4 1.0 7.3 2.4 2.8 100.7 13.0 19.1 30.5 24.1 25.4 39.3 26.0 24.7 18.1 26.7 20.2 27.2 2.8 33.1 47.6 20.9 52.2 24.8 18.8 24.5 20.6 26.8 19.1 22.6 20.3 20.8 20.6 20.5 20.8 21.1 6.2 12.8 8.7 14.7 9.3 6.8 3.2 7.3 4.0 8.9 10.0 8.4 9.9 10.0 8.8 5.5 0.0 8.0 11.3 8.4 80.3 11.3 0.4 34.6 2.0 5.6 7.3 2.5 4.7 16.1 4.6 8.0 4.6 7.0 20.8 10.2 3.3 44.3 11.1 10.1 5.6 12.8 12.2 11.6 7.5 2.0 4.4 8.2 12.4 11.2 19.8 38.0 24.7 8.0 11.4 5.4 21.7 4.1 12.1 4.6 84.2 224.4 28.3 3.5 0.0 8.8 5.9 1.4 1.5 5.4 5.8 3.0 13.7 9.9 11.2 4.2 IGF1R "CD221, IGFIR, IGFR, JTK13, MGC18216" ENSG00000140443 "Insulin like growth factor 1 receptor" P08069 15 98648539-98964530 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" "Host-virus interaction" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 239.4;Inhibitory neurons: 194.6;Microglial cells: 245.4;Oligodendrocyte precursor cells: 237.7;Oligodendrocytes: 261.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "neutrophil: 4.3" "Group enriched" "Detected in many" 6 "granulocytes: 4.3;T-cells: 1.4" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010268, HPA045563" Approved NA NA 46000 "Cluster 50: Neutrophils - Cellular senescence" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 20: HeLa - Mitochondria" "Cluster 40: Granulosa cells - Unknown function" "CAB010268: AB_671792, HPA045563: AB_2679368" "unprognostic (1.30e-3)" "unprognostic (5.81e-3)" "unprognostic (1.53e-1)" "unprognostic (3.34e-2)" "unprognostic (2.65e-1)" "unprognostic (2.05e-2)" "unprognostic (1.29e-2)" "unprognostic (6.87e-2)" "unprognostic (2.64e-2)" "unprognostic (2.87e-2)" "unprognostic (8.56e-2)" "unprognostic (1.62e-1)" "prognostic favorable (3.75e-7)" "unprognostic (1.57e-1)" "unprognostic (3.59e-1)" "unprognostic (1.41e-1)" "unprognostic (1.06e-1)" 7.3 11.3 10.1 3.6 11.2 11.0 12.2 12.0 12.0 10.1 35.5 12.5 2.5 11.0 11.1 7.5 13.0 4.5 9.6 9.5 8.2 11.6 0.9 9.5 2.7 12.4 13.4 15.8 15.4 2.1 8.8 12.1 11.2 14.7 4.5 16.0 10.0 9.6 7.0 11.1 6.5 6.1 10.3 5.8 9.6 8.4 13.2 6.1 12.9 11.6 3.4 9.9 10.0 11.1 6.1 34.0 22.6 0.2 11.9 8.3 16.3 8.0 14.5 2.5 2.2 15.6 17.5 1.6 22.1 13.8 14.7 31.6 10.9 25.0 1.9 0.1 11.1 27.5 32.3 31.2 10.4 11.1 2.5 12.1 14.9 4.5 18.6 9.3 8.4 2.8 1.4 5.4 9.9 48.1 5.4 9.8 23.0 11.8 1.3 7.7 19.3 6.7 7.4 37.8 8.1 35.9 56.0 3.3 30.1 50.2 16.7 3.8 24.5 1.5 26.5 6.5 12.0 1.9 9.8 5.9 4.6 10.0 5.9 1.9 0.3 0.9 0.4 0.2 0.2 0.1 0.3 0.1 0.1 0.4 1.4 0.4 4.3 0.5 0.3 0.1 0.0 0.3 10.1 11.2 12.0 12.0 9.5 8.2 12.4 13.4 11.2 10.3 13.2 11.1 30.8 28.9 13.4 157.7 3.5 32.8 28.8 31.1 35.3 51.5 58.3 33.4 30.8 5.7 30.2 22.0 91.8 33.7 8.0 10.7 1.9 16.6 27.6 79.7 39.6 26.1 35.0 7.8 239.4 11.2 20.3 25.2 11.2 91.3 0.0 106.5 52.5 1.5 6.5 75.7 194.6 21.1 20.3 6.6 8.3 53.4 18.0 8.3 21.4 245.4 8.5 45.6 14.4 237.7 261.0 29.1 12.9 13.5 4.3 70.9 5.3 21.8 55.4 36.1 0.0 20.4 27.6 4.0 17.2 17.9 32.0 27.5 6.4 20.9 24.5 51.5 IKBKB "IKK-beta, IKK2, IKKB, NFKBIKB" ENSG00000104365 "Inhibitor of nuclear factor kappa B kinase subunit beta" O14920 8 42271302-42332460 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins" "Host-virus interaction" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, FDA approved drug targets, SCID" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 135.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001249, CAB004447" Enhanced Supported Cytosol NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 80: Striated muscle - Unknown function" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 9: Photoreceptor cells - Phototransduction" Cytosol "CAB004447: AB_627785, HPA001249: AB_1079126" "unprognostic (1.04e-1)" "unprognostic (2.30e-2)" "unprognostic (1.31e-1)" "unprognostic (1.73e-3)" "unprognostic (1.26e-1)" "unprognostic (1.27e-3)" "unprognostic (1.95e-1)" "unprognostic (1.25e-3)" "unprognostic (1.75e-1)" "unprognostic (1.55e-1)" "unprognostic (3.27e-1)" "unprognostic (1.73e-1)" "unprognostic (1.20e-2)" "unprognostic (1.89e-2)" "unprognostic (9.20e-2)" "unprognostic (3.02e-1)" "prognostic favorable (1.46e-6)" 9.4 8.2 9.1 4.7 9.8 4.8 8.3 9.2 10.9 7.2 11.7 6.8 4.8 8.1 7.3 10.2 11.6 8.6 5.6 9.2 9.5 6.8 6.6 11.3 12.2 10.5 9.9 6.1 6.2 13.5 4.0 8.2 10.0 7.9 6.8 12.3 8.9 9.3 13.7 11.4 4.9 12.7 9.7 10.5 5.5 3.2 10.1 10.8 9.4 24.3 11.6 11.1 6.8 10.2 6.2 15.7 8.0 13.6 17.3 18.9 5.8 9.2 18.2 15.2 17.2 3.1 13.9 14.1 10.0 16.5 12.5 5.6 8.4 18.3 17.8 9.8 10.8 17.8 7.8 5.9 20.9 6.1 24.0 12.3 13.7 15.0 19.1 36.1 20.7 11.6 12.8 6.9 34.6 5.1 13.9 11.3 6.1 18.9 6.0 11.1 15.3 10.0 19.6 5.7 1.3 4.7 6.4 6.4 11.7 10.0 8.7 23.6 13.6 7.2 3.9 13.9 6.1 2.8 4.0 10.3 13.8 7.6 16.7 7.4 5.0 5.6 4.6 4.1 4.3 4.4 5.1 5.5 3.7 4.8 4.8 4.7 5.2 5.1 5.5 8.5 5.9 2.9 9.1 9.8 9.2 10.9 9.2 9.5 10.5 9.9 10.0 9.7 10.1 10.2 31.3 12.8 26.9 19.2 28.4 24.3 34.1 13.9 25.6 12.7 20.6 15.5 8.8 14.3 15.4 16.5 135.5 10.4 34.1 15.9 1.9 13.4 2.3 13.9 15.6 27.4 11.4 10.1 19.7 13.6 5.3 12.4 21.9 16.5 38.0 24.0 19.6 12.0 18.6 18.5 20.6 16.4 8.2 32.3 24.0 3.4 16.4 23.4 19.6 58.1 33.7 8.7 47.4 17.1 30.2 16.6 15.0 12.8 18.2 31.9 13.2 5.5 20.2 47.9 6.6 13.1 11.4 4.8 7.0 17.8 29.1 15.2 24.3 6.2 14.1 30.8 IKBKE "IKK-i, IKKE, KIAA0151" ENSG00000263528 "Inhibitor of nuclear factor kappa B kinase subunit epsilon" Q14164 1 206470476-206496889 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, Host-virus interaction" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 24.3" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 37.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "NB-4: 47.7" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA015788, CAB025983" Approved Supported Cytosol NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 24: NB-4 - Immune response" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Cytosol "CAB025983: , HPA015788: AB_1851566" "unprognostic (6.43e-2)" "unprognostic (3.04e-1)" "unprognostic (1.48e-1)" "unprognostic (5.76e-2)" "unprognostic (7.78e-3)" "unprognostic (7.37e-3)" "unprognostic (1.99e-3)" "unprognostic (2.82e-1)" "unprognostic (5.09e-3)" "unprognostic (1.30e-1)" "unprognostic (1.50e-1)" "unprognostic (1.27e-1)" "prognostic unfavorable (5.34e-7)" "unprognostic (1.48e-2)" "unprognostic (5.77e-2)" "unprognostic (2.84e-3)" "unprognostic (2.84e-2)" 2.4 3.7 2.6 16.7 4.6 8.7 3.1 2.0 3.2 4.1 1.9 7.8 7.4 1.7 3.9 14.6 2.8 5.1 1.4 2.7 3.3 3.4 1.6 4.1 24.3 4.1 3.6 1.2 3.4 1.0 1.9 2.6 3.9 3.6 7.7 0.1 6.9 2.1 0.5 15.0 8.0 2.5 2.7 14.2 7.2 0.7 4.4 16.5 4.5 0.3 20.4 8.4 6.8 4.6 17.8 13.9 3.7 0.4 6.7 9.2 3.9 7.1 22.3 9.4 10.4 11.5 26.9 35.3 18.6 14.5 11.5 23.0 0.1 18.1 2.2 5.5 3.5 4.7 8.8 7.6 8.4 29.5 14.8 12.2 3.2 7.7 1.7 10.9 14.2 9.4 2.3 10.0 10.5 3.6 19.2 47.7 5.2 4.3 10.9 9.7 4.3 27.7 10.7 29.4 0.0 0.0 2.9 22.9 4.2 4.5 13.8 20.3 26.5 9.0 5.5 6.9 8.5 3.5 1.8 23.3 17.1 24.2 3.7 12.2 32.8 0.6 21.2 23.3 14.8 26.4 32.4 30.1 9.5 14.0 25.7 27.3 2.2 23.9 13.4 3.2 52.8 28.6 2.6 4.6 2.0 3.2 2.7 3.3 4.1 3.6 3.9 2.7 4.4 4.6 0.4 0.0 4.5 0.7 13.7 1.9 3.6 37.8 1.8 0.0 4.3 3.7 0.9 4.3 16.3 0.0 0.0 4.2 7.9 11.7 0.0 12.1 3.3 1.5 0.9 0.7 3.6 4.4 1.5 12.6 5.2 3.4 17.3 2.4 5.1 3.7 2.2 0.8 13.8 0.0 1.5 6.4 8.2 12.9 0.7 7.0 0.9 16.0 7.2 1.9 9.0 0.0 14.4 1.0 0.2 15.9 21.5 0.7 6.4 3.2 10.7 3.5 14.5 0.0 0.0 0.7 3.1 0.3 0.9 11.1 4.8 1.5 15.8 3.9 10.2 11.6 ILK ENSG00000166333 "Integrin linked kinase" Q13418 11 6603708-6610874 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004041, HPA048437" Enhanced Supported "Nucleoplasm,Plasma membrane,Focal adhesion sites" NA NA 30000000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 51: Myeloid cells - Hemostasis" "Plasma membrane, Focal adhesion sites" Nucleoplasm "CAB004041: AB_2127050, HPA048437: AB_2680391" "unprognostic (1.78e-1)" "unprognostic (2.26e-2)" "unprognostic (5.26e-2)" "unprognostic (2.12e-2)" "unprognostic (7.57e-2)" "unprognostic (1.01e-1)" "unprognostic (6.19e-3)" "unprognostic (5.25e-3)" "unprognostic (1.49e-2)" "unprognostic (9.65e-2)" "unprognostic (2.64e-1)" "unprognostic (8.12e-2)" "prognostic favorable (2.44e-4)" "unprognostic (4.01e-3)" "unprognostic (9.27e-2)" "unprognostic (2.42e-1)" "unprognostic (6.36e-3)" 108.0 77.2 49.8 85.1 52.4 43.7 91.8 51.7 50.6 151.6 55.0 398.2 66.4 359.1 81.8 115.5 164.2 88.0 175.9 47.4 50.7 78.8 65.9 107.9 72.4 51.8 50.6 101.0 89.3 73.2 47.1 98.8 50.9 182.7 116.8 28.3 69.5 412.2 90.8 61.5 117.4 364.7 51.1 95.5 149.7 26.5 53.7 45.8 72.0 92.0 70.5 226.7 118.8 51.9 127.8 94.4 148.9 51.8 224.8 159.4 67.2 182.2 360.0 211.9 256.0 102.7 145.7 47.0 47.0 304.1 206.9 99.5 84.4 155.6 213.0 83.5 74.3 69.1 84.9 82.8 150.8 55.9 74.7 153.2 72.8 143.8 108.9 217.7 206.9 40.5 63.7 55.0 282.8 97.1 49.4 97.4 94.3 107.5 110.8 51.0 77.8 50.5 160.3 100.8 25.6 57.4 86.0 118.4 103.6 144.0 82.2 62.2 238.8 263.9 118.0 111.1 90.7 38.9 25.9 67.1 195.6 82.8 125.3 314.9 260.0 417.6 127.3 258.1 124.9 96.9 114.4 122.3 242.7 92.9 70.2 88.5 165.5 257.8 254.8 98.5 142.8 402.8 49.8 52.4 51.7 50.6 47.4 50.7 51.8 50.6 50.9 51.1 53.7 51.9 79.5 44.8 17.9 24.2 33.6 50.5 73.7 100.6 24.5 21.5 43.1 68.2 0.5 70.1 49.7 57.0 8.4 119.8 46.0 71.9 58.7 136.1 64.6 33.2 78.1 69.4 37.9 53.7 14.6 125.0 177.7 83.2 50.4 52.5 30.4 41.6 76.4 31.4 127.4 8.4 17.1 50.1 69.2 51.5 97.7 143.7 71.4 115.9 85.4 30.9 143.0 54.3 77.2 15.6 15.3 117.1 60.0 147.4 35.1 42.0 74.5 98.6 31.0 32.9 157.8 53.3 165.8 31.7 17.1 32.3 43.2 110.0 49.3 65.0 50.1 43.9 INMT ENSG00000241644 "Indolethylamine N-methyltransferase" O95050 7 30697985-30757602 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Detoxification "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lung: 205.8" "Group enriched" "Detected in many" 7 "Endothelial cells: 150.4;Hepatic stellate cells: 268.4;Leydig cells: 285.2;Peritubular cells: 455.5" "Cancer enhanced" "Detected in many" "thyroid cancer: 22.2" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "basophil: 1.6" "Low lineage specificity" "Detected in single" "Group enriched" "Detected in some" 5 "CACO-2: 16.7;HHSteC: 6.7" HPA061343 Approved "Golgi apparatus,Vesicles" NA NA "Cluster 17: Basophils - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 39: CACO-2 - Unknown function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Golgi apparatus, Vesicles" "HPA061343: AB_2684483" "unprognostic (1.70e-1)" "unprognostic (4.36e-2)" "unprognostic (5.26e-2)" "unprognostic (6.78e-3)" "unprognostic (1.59e-1)" "unprognostic (3.39e-4)" "prognostic favorable (5.72e-4)" "unprognostic (3.08e-2)" "unprognostic (3.94e-2)" "unprognostic (1.59e-1)" "unprognostic (8.51e-2)" "unprognostic (9.07e-2)" "unprognostic (4.97e-2)" "unprognostic (1.62e-2)" "unprognostic (1.43e-2)" "unprognostic (9.71e-2)" "unprognostic (1.58e-2)" 64.5 51.2 3.1 2.7 6.0 0.7 10.2 7.9 13.1 6.4 9.3 9.5 2.8 16.0 25.4 15.0 43.8 8.3 75.6 7.6 8.7 20.0 23.3 205.8 7.6 9.6 6.0 17.7 11.3 5.7 7.8 33.7 5.6 29.6 4.6 0.5 9.1 48.0 14.4 4.2 8.5 25.7 2.5 13.0 12.7 15.8 4.8 1.7 21.3 13.2 4.0 11.1 7.2 16.6 0.0 0.1 0.0 0.1 1.5 2.1 0.3 0.2 2.1 0.0 0.0 16.7 0.1 0.0 0.0 0.5 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.2 6.7 0.1 0.3 0.8 0.0 0.0 0.0 0.0 0.4 0.2 0.1 0.2 0.2 0.1 0.0 0.4 0.7 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.2 0.5 0.1 0.6 0.0 0.6 0.1 0.0 1.0 0.0 0.6 0.2 0.0 0.7 0.3 0.0 0.2 0.1 0.3 1.6 0.2 0.2 0.2 0.1 0.1 0.3 0.1 0.1 0.1 0.4 0.2 0.2 0.8 0.5 0.1 0.3 0.1 0.2 3.1 6.0 7.9 13.1 7.6 8.7 9.6 6.0 5.6 2.5 4.8 16.6 39.4 0.0 3.6 0.0 1.0 2.2 0.1 0.0 1.2 0.0 0.4 0.6 10.0 7.2 2.5 0.0 0.0 0.7 0.3 0.0 0.0 0.0 2.3 0.1 0.8 150.4 1.2 8.0 0.0 0.0 0.4 38.2 0.0 0.0 0.0 0.9 268.4 5.1 0.8 0.0 0.0 0.2 0.0 16.6 4.4 16.0 285.2 0.7 3.6 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 455.5 1.5 0.2 0.0 0.1 0.7 0.0 32.9 5.0 19.6 1.3 1.3 0.4 2.3 1.8 1.3 0.2 0.0 0.4 INSR CD220 ENSG00000171105 "Insulin receptor" P06213 19 7112255-7294414 "CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" "Carbohydrate metabolism" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Diabetes mellitus, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in many" 8 "dendritic cells: 9.8;granulocytes: 5.9;monocytes: 12.5" "Cell line enhanced" "Detected in many" "Karpas-707: 54.9;U-266/70: 40.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036302, HPA036303" Uncertain Approved "Vesicles,Plasma membrane" NA Yes 190000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 22: Non-specific - Unknown function" "Cluster 2: Karpas-707 - Immune response" "Cluster 52: Non-specific - Transcription" Vesicles "Plasma membrane" "HPA036302: AB_2675048, HPA036303: " "unprognostic (4.64e-2)" "unprognostic (2.42e-1)" "unprognostic (9.65e-3)" "unprognostic (9.70e-2)" "unprognostic (1.44e-1)" "unprognostic (1.15e-2)" "unprognostic (2.58e-1)" "unprognostic (5.09e-2)" "unprognostic (1.97e-1)" "unprognostic (3.05e-1)" "unprognostic (9.29e-2)" "unprognostic (1.86e-1)" "unprognostic (6.33e-2)" "unprognostic (3.45e-3)" "unprognostic (2.43e-1)" "unprognostic (2.75e-1)" "unprognostic (8.82e-2)" 13.0 22.6 12.5 2.8 16.8 5.6 13.0 17.3 12.8 14.6 18.8 15.0 10.0 18.4 6.3 4.1 16.9 8.2 26.3 10.0 12.2 21.8 33.0 7.2 2.3 18.3 16.3 39.9 64.2 13.0 16.3 7.4 18.7 15.2 10.4 6.5 16.9 9.9 23.5 11.5 12.2 11.5 14.1 48.2 12.5 5.4 16.6 2.7 14.5 13.3 3.5 12.3 9.2 22.5 6.2 3.2 3.6 5.7 18.8 6.1 11.1 3.5 2.9 1.6 1.6 8.4 7.0 9.0 8.2 6.8 4.0 1.6 8.9 1.4 1.2 0.0 6.4 0.0 2.3 22.6 8.2 4.3 6.7 10.0 4.5 0.2 4.9 4.2 3.8 4.8 9.5 54.9 1.8 3.2 3.1 7.8 3.3 3.8 5.2 29.0 2.1 7.6 0.1 27.8 6.6 5.2 6.5 3.8 3.3 6.4 1.4 21.6 3.6 3.4 2.1 8.2 5.1 40.4 23.9 20.2 4.3 7.3 0.0 2.7 8.6 5.9 0.2 8.8 0.3 0.8 0.3 0.1 9.8 1.1 0.7 0.1 1.9 1.0 12.5 8.2 0.0 1.6 12.5 16.8 17.3 12.8 10.0 12.2 18.3 16.3 18.7 14.1 16.6 22.5 75.6 48.1 34.7 64.9 10.6 64.9 63.6 34.7 8.0 40.4 134.0 76.2 92.1 137.2 83.3 62.5 79.2 17.8 6.7 124.1 15.6 55.1 4.7 26.8 106.8 123.9 163.6 25.0 68.3 78.7 53.7 43.7 20.4 42.1 3.8 168.4 255.2 246.0 9.2 38.7 100.8 97.3 32.6 49.0 31.1 9.0 96.3 35.0 51.6 62.8 24.2 31.6 0.0 62.8 183.5 50.7 68.8 245.3 21.8 107.9 122.9 114.1 65.3 23.6 59.2 37.6 44.2 5.2 3.6 3.2 68.8 38.3 4.7 81.4 65.2 130.0 INSRR IRR ENSG00000027644 "Insulin receptor related receptor" P14616 1 156840063-156859117 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "brain: 14.5;kidney: 3.8" "Cell type enhanced" "Detected in some" "Bipolar cells: 1.9;Cardiomyocytes: 2.3;Early spermatids: 2.8;Spermatocytes: 4.1;Spermatogonia: 5.2" "Not detected" "Not detected" "Group enriched" "Detected in many" 7 "medulla oblongata: 14.5;pons: 13.4" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 7 "SCLC-21H: 4.6;SH-SY5Y: 15.9" "Not detected" "Not detected" "Not detected" "Not detected" HPA025285 Uncertain NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" "HPA025285: AB_1851814" "unprognostic (1.19e-1)" "unprognostic (7.69e-2)" "unprognostic (2.42e-2)" "unprognostic (6.76e-4)" "unprognostic (1.51e-1)" "unprognostic (9.07e-3)" "unprognostic (5.57e-2)" "unprognostic (1.75e-1)" "unprognostic (6.17e-2)" "unprognostic (5.57e-2)" "unprognostic (2.20e-2)" "unprognostic (7.00e-2)" "unprognostic (4.22e-5)" "unprognostic (2.82e-1)" "unprognostic (9.55e-2)" "unprognostic (2.75e-3)" "unprognostic (3.66e-2)" 0.5 1.4 0.0 0.0 0.5 0.0 0.2 1.2 1.9 1.3 0.2 0.1 0.0 0.5 0.0 0.0 0.4 0.0 0.2 0.0 0.5 3.8 0.0 0.0 0.0 14.5 0.6 0.0 0.2 0.0 0.6 0.0 13.4 0.6 0.0 0.2 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 1.7 2.0 0.3 0.3 0.1 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 4.6 15.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 1.2 1.9 0.0 0.5 14.5 0.6 13.4 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.7 0.1 0.0 0.0 0.3 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 4.1 5.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 IP6K1 "IHPK1, KIAA0263" ENSG00000176095 "Inositol hexakisphosphate kinase 1" Q92551 3 49724294-49786542 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040825 Approved Supported "Nucleoplasm,Nucleoli fibrillar center,Cytosol" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 43: Testis - Unknown function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 9: Photoreceptor cells - Phototransduction" "Nucleoli fibrillar center" "Nucleoplasm, Cytosol" "HPA040825: AB_10960426" "unprognostic (6.18e-2)" "unprognostic (1.33e-1)" "unprognostic (3.58e-2)" "unprognostic (4.71e-2)" "unprognostic (1.99e-1)" "prognostic favorable (2.08e-4)" "unprognostic (9.97e-3)" "unprognostic (8.45e-2)" "unprognostic (1.16e-1)" "unprognostic (2.11e-1)" "prognostic favorable (6.85e-4)" "unprognostic (1.29e-2)" "prognostic favorable (5.77e-5)" "unprognostic (8.75e-2)" "unprognostic (1.67e-1)" "unprognostic (9.24e-2)" "unprognostic (1.64e-2)" 17.9 20.2 32.4 12.1 33.6 12.5 17.2 27.6 34.9 21.5 17.2 24.1 12.1 25.6 12.2 20.0 19.4 12.9 15.8 35.9 27.7 21.3 14.6 17.5 13.3 26.4 28.2 25.5 19.8 22.8 21.5 16.4 27.4 18.1 11.3 18.3 17.4 17.2 12.6 23.1 17.8 16.9 24.5 21.9 18.5 32.2 30.7 17.2 16.2 11.4 13.2 19.1 16.0 29.0 20.6 24.5 27.9 33.1 28.6 21.8 22.5 26.6 27.8 42.7 37.3 31.9 20.9 17.3 16.8 29.7 28.8 14.9 39.8 24.2 24.0 35.6 30.6 40.5 36.1 21.8 31.4 25.0 26.7 25.6 29.4 46.4 27.8 24.0 36.1 20.3 26.7 20.3 21.4 18.2 30.6 25.6 30.2 16.1 37.6 19.1 19.8 35.7 27.7 30.8 15.0 29.8 33.4 21.8 30.6 16.0 17.6 36.2 32.8 23.9 23.6 33.1 31.0 24.3 35.6 18.8 21.9 28.4 24.9 4.7 7.3 12.1 11.7 5.4 11.4 6.0 10.4 12.8 5.6 8.4 12.6 12.7 33.3 10.3 7.0 4.1 11.8 9.5 32.4 33.6 27.6 34.9 35.9 27.7 26.4 28.2 27.4 24.5 30.7 29.0 17.1 25.6 12.3 24.5 25.0 15.6 14.7 7.4 11.4 38.4 19.7 15.0 8.8 18.6 10.1 12.9 89.6 19.2 27.6 22.0 5.9 14.5 88.2 24.9 19.9 19.0 27.6 24.2 42.3 13.0 16.1 14.7 14.8 17.3 19.7 19.6 19.6 12.2 12.8 30.3 46.6 14.1 10.2 15.0 14.2 23.7 21.1 17.8 19.6 31.9 15.9 19.6 35.0 43.7 39.8 19.2 8.8 16.6 28.9 19.6 14.6 12.5 21.8 78.3 19.7 16.2 18.3 24.6 21.9 13.7 18.8 27.5 27.6 30.5 12.8 20.4 IP6K3 "IHPK3, INSP6K3" ENSG00000161896 "Inositol hexakisphosphate kinase 3" Q96PC2 6 33721662-33746905 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 7 "skeletal muscle: 308.1;tongue: 83.3" "Cell type enhanced" "Detected in some" "Bipolar cells: 8.5;Cardiomyocytes: 11.2;Hepatocytes: 8.9;Horizontal cells: 10.1;Oligodendrocytes: 15.3;Proximal tubular cells: 8.2;Skeletal myocytes: 51.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HHSteC: 21.9;HSkMC: 7.9;LHCN-M2: 36.2;RH-30: 15.7" "Low region specificity" "Detected in some" "Not detected" "Not detected" "HPA053644, HPA062531" Enhanced Approved Nucleoplasm,Cytosol Yes NA "Cluster 80: Striated muscle - Unknown function" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 37: Myocytes - Muscle contraction" Nucleoplasm Cytosol "HPA053644: AB_2682214, HPA062531: " "unprognostic (3.23e-2)" "unprognostic (2.87e-1)" "unprognostic (2.07e-5)" "unprognostic (1.07e-3)" "unprognostic (2.20e-1)" "unprognostic (5.10e-3)" "unprognostic (1.38e-1)" "unprognostic (1.75e-1)" "unprognostic (2.45e-1)" "unprognostic (2.47e-2)" "unprognostic (1.24e-2)" "unprognostic (2.94e-3)" "prognostic unfavorable (6.09e-4)" "unprognostic (1.63e-2)" "unprognostic (2.01e-1)" "unprognostic (2.66e-3)" "unprognostic (1.33e-1)" 1.4 0.7 4.8 0.4 15.5 0.0 1.3 12.2 9.5 1.9 5.7 6.8 0.4 3.8 0.1 6.5 1.2 0.1 29.6 5.9 8.8 6.0 18.8 5.2 0.1 14.7 13.1 0.5 0.6 0.0 0.5 4.7 15.0 5.3 0.6 0.9 2.7 1.6 308.1 0.7 2.3 1.8 7.0 3.3 1.6 0.2 12.4 0.5 12.9 83.3 0.0 2.4 1.9 27.1 0.1 0.0 0.5 0.0 0.0 0.1 3.6 0.1 0.4 0.3 2.6 0.0 0.0 0.0 0.5 0.0 0.1 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.1 21.9 0.0 0.1 7.9 1.2 0.1 0.6 0.1 0.0 0.0 0.0 0.0 36.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 15.7 0.0 0.0 0.0 0.4 0.1 0.0 0.7 0.5 5.3 0.0 0.3 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.8 15.5 12.2 9.5 5.9 8.8 14.7 13.1 15.0 7.0 12.4 27.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.2 0.0 8.5 0.4 0.4 11.2 0.0 1.4 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.4 5.0 0.2 0.0 0.0 0.2 0.0 0.1 0.9 0.0 0.2 0.0 0.0 0.0 8.9 0.3 10.1 0.1 0.0 0.0 0.0 0.0 0.1 0.9 0.1 0.0 0.0 0.0 1.1 0.0 0.0 15.3 0.0 0.0 0.0 0.0 0.0 0.0 8.2 1.0 0.4 6.6 51.7 1.0 0.0 0.0 0.0 0.0 0.7 0.0 0.1 0.0 0.2 IPMK ENSG00000151151 "Inositol polyphosphate multikinase" Q8NFU5 10 58191517-58267894 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Lipid metabolism, Phospholipid metabolism" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Suprabasal keratinocytes: 58.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "neutrophil: 3.0" "Group enriched" "Detected in many" 4 "granulocytes: 3.0;monocytes: 1.0" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037837, HPA057542" Uncertain Enhanced Nucleoplasm NA NA "Cluster 34: Basophils - Unknown function" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 41: Macrophages - Immune response" Nucleoplasm "HPA037837: AB_10670166, HPA057542: AB_2683460" "unprognostic (4.52e-2)" "unprognostic (3.29e-2)" "unprognostic (4.22e-3)" "unprognostic (6.85e-2)" "unprognostic (2.41e-2)" "unprognostic (1.99e-1)" "unprognostic (1.39e-3)" "unprognostic (2.10e-1)" "unprognostic (9.39e-2)" "unprognostic (2.23e-1)" "unprognostic (1.55e-1)" "unprognostic (8.56e-2)" "prognostic unfavorable (9.96e-7)" "unprognostic (1.79e-1)" "unprognostic (4.33e-1)" "unprognostic (1.27e-3)" "unprognostic (9.02e-3)" 4.9 3.1 3.1 5.8 3.1 2.4 4.7 4.1 4.5 4.4 2.3 7.1 7.9 2.3 3.4 5.2 2.9 6.9 1.8 2.9 3.2 4.1 18.1 3.3 4.6 3.6 3.6 1.8 3.8 12.1 1.9 8.7 3.2 3.4 6.0 4.7 2.7 1.7 2.7 5.1 10.4 1.9 3.2 6.4 3.5 2.2 3.5 4.5 4.1 3.2 4.4 5.2 2.5 3.2 16.3 4.1 5.9 5.8 5.7 6.6 5.1 4.2 9.0 3.5 7.1 8.3 10.1 13.0 8.3 5.0 3.4 4.9 5.0 5.6 11.2 5.9 3.8 3.2 3.9 7.9 3.4 5.1 7.1 7.3 4.9 6.0 12.0 4.0 7.7 3.7 2.1 6.5 6.3 4.1 7.0 9.8 3.8 6.6 3.8 0.5 12.8 6.0 6.6 4.1 4.1 7.1 5.5 14.4 4.3 9.6 12.0 6.1 6.7 3.8 7.4 8.1 5.4 13.8 8.7 10.1 7.2 5.3 1.5 1.7 0.7 1.6 0.1 0.7 0.1 0.3 0.1 0.1 0.4 0.2 0.4 0.1 3.0 0.2 1.0 0.2 0.0 0.1 3.1 3.1 4.1 4.5 2.9 3.2 3.6 3.6 3.2 3.2 3.5 3.2 8.9 6.4 4.2 16.6 16.9 54.0 10.0 8.4 26.2 10.0 11.6 8.3 2.8 4.3 13.3 1.8 6.2 10.5 8.1 29.3 3.9 4.2 3.0 24.3 9.7 9.9 8.4 3.0 21.8 4.9 22.5 15.7 8.2 22.8 7.0 2.5 8.2 13.2 10.0 13.5 27.8 10.6 10.2 22.8 40.7 1.4 2.8 29.1 26.6 24.4 16.6 5.4 2.1 30.7 23.6 6.2 21.7 1.9 8.5 9.6 28.6 9.1 29.1 5.8 6.6 10.2 8.5 10.0 5.1 20.1 58.1 9.4 10.1 4.1 11.1 17.5 IPPK "C9orf12, FLJ13163, INSP5K2, IP5K, IPK1" ENSG00000127080 "Inositol-pentakisphosphate 2-kinase" Q9H8X2 9 92613183-92670131 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "esophagus: 31.6" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA020603 Uncertain Approved Cytosol NA NA "Cluster 13: T-cells - Unknown function" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 28: BEWO - Transcription regulation" "Cluster 61: Squamous epithelial cells - Keratinization" Cytosol "HPA020603: AB_1851853" "unprognostic (3.51e-2)" "unprognostic (4.66e-2)" "unprognostic (6.26e-2)" "unprognostic (1.26e-1)" "unprognostic (3.63e-2)" "unprognostic (2.08e-1)" "unprognostic (4.88e-2)" "unprognostic (3.13e-2)" "unprognostic (4.40e-2)" "unprognostic (1.10e-1)" "unprognostic (2.68e-1)" "unprognostic (1.98e-1)" "unprognostic (6.26e-9)" "unprognostic (1.28e-2)" "unprognostic (4.23e-2)" "unprognostic (2.83e-1)" "prognostic unfavorable (1.28e-4)" 5.4 6.9 5.2 4.5 5.7 8.5 6.4 7.5 6.4 9.1 3.9 4.1 3.2 5.2 4.8 31.6 5.4 4.6 7.8 6.9 4.7 4.4 5.3 4.7 5.7 5.5 5.1 5.4 3.6 8.5 8.1 5.5 5.7 4.2 4.4 5.7 8.8 2.8 7.6 29.8 4.2 5.4 5.0 5.4 4.6 11.6 5.6 5.9 4.6 6.1 8.7 5.7 15.5 5.6 19.3 10.1 9.2 8.0 11.1 8.2 30.4 13.5 8.5 13.6 7.8 6.3 7.4 11.9 6.6 18.9 12.0 27.1 16.4 18.9 11.3 14.9 10.4 9.8 21.9 9.9 7.8 16.7 11.2 8.1 18.4 16.3 12.7 12.4 10.3 9.8 13.5 14.1 13.6 26.3 9.6 7.7 15.8 21.2 14.9 8.5 9.8 4.9 8.0 11.5 19.1 11.2 10.9 44.9 7.8 8.9 10.6 4.2 19.7 10.0 11.3 28.2 14.4 13.0 16.2 6.5 13.0 7.5 9.9 0.0 1.4 3.4 3.6 1.8 4.1 2.4 3.0 3.1 2.1 2.2 2.3 2.6 2.1 0.8 1.9 2.3 4.6 1.9 5.2 5.7 7.5 6.4 6.9 4.7 5.5 5.1 5.7 5.0 5.6 5.6 6.8 3.2 3.4 10.1 4.8 25.4 6.4 7.6 16.5 7.5 6.0 4.7 0.4 1.5 5.1 1.8 6.2 10.8 4.6 5.0 5.9 6.2 11.0 8.3 5.3 6.8 6.7 6.1 23.8 8.0 13.8 4.1 7.1 10.2 0.0 3.6 10.0 3.1 5.1 15.2 23.7 3.5 6.1 7.5 4.6 33.7 3.1 5.3 3.6 7.5 2.8 4.9 8.2 20.6 23.3 9.1 1.4 3.0 6.0 6.4 2.6 3.6 2.6 4.6 6.6 3.9 3.5 20.0 19.4 25.5 29.5 22.8 6.0 4.4 3.7 10.5 IRAK1 "IRAK, pelle" ENSG00000184216 "Interleukin 1 receptor associated kinase 1" P51617 X 154010506-154019902 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Host-virus interaction, Immunity, Innate immunity" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Exocrine glandular cells: 113.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004461, HPA054476" Supported Supported Nucleoplasm,Cytosol No No "Cluster 15: NK-cells - Transcription" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 1: Pancreatic cells - Digestion" Cytosol Nucleoplasm "CAB004461: AB_2249106, HPA054476: AB_2682501" "unprognostic (4.46e-3)" "unprognostic (9.32e-2)" "unprognostic (1.71e-2)" "unprognostic (5.04e-3)" "unprognostic (7.09e-3)" "unprognostic (4.43e-3)" "prognostic unfavorable (3.03e-4)" "unprognostic (7.89e-3)" "unprognostic (3.36e-2)" "unprognostic (3.69e-2)" "unprognostic (1.95e-1)" "unprognostic (6.64e-2)" "prognostic unfavorable (2.06e-4)" "unprognostic (2.76e-3)" "unprognostic (2.36e-1)" "unprognostic (2.21e-3)" "unprognostic (3.04e-1)" 48.6 61.2 24.4 37.6 25.3 82.4 40.7 23.6 34.9 29.0 20.0 41.4 43.3 31.8 7.7 69.1 28.8 20.2 34.4 22.3 26.5 44.2 64.7 48.9 33.7 38.1 30.0 28.9 84.9 12.4 37.5 17.8 30.8 46.1 15.0 4.5 41.6 21.0 92.5 44.3 51.1 16.4 29.6 69.9 41.9 20.8 34.3 19.4 24.5 16.8 24.0 47.7 36.5 29.4 467.2 178.9 24.5 201.2 48.4 38.5 108.3 68.8 64.5 104.0 96.0 142.3 199.4 200.8 371.4 73.6 157.6 124.3 57.6 112.4 39.8 156.7 173.4 73.3 158.6 85.7 110.8 174.2 118.7 53.2 96.1 99.0 107.8 53.2 62.8 39.6 130.9 220.3 73.3 171.4 70.8 152.1 60.9 148.4 353.5 181.6 126.4 334.7 68.5 86.3 137.4 98.7 82.2 88.6 135.2 9.5 34.3 179.2 86.4 123.8 194.6 284.6 424.2 274.8 190.6 358.2 179.6 205.1 130.8 1.3 7.2 6.2 5.3 9.2 4.7 6.5 4.3 4.4 4.8 7.9 2.5 4.7 5.2 5.4 7.5 10.9 2.3 3.3 24.4 25.3 23.6 34.9 22.3 26.5 38.1 30.0 30.8 29.6 34.3 29.4 20.2 0.0 13.3 5.9 29.7 13.4 14.5 10.9 5.2 9.1 23.9 19.0 9.3 18.6 16.0 11.0 6.2 11.4 33.0 41.4 7.9 40.5 0.9 9.8 13.5 18.1 20.4 18.1 9.7 113.6 20.9 15.2 18.3 17.3 12.7 25.5 13.2 35.9 57.2 16.8 8.9 27.2 0.0 51.4 24.7 3.8 18.0 43.0 14.2 11.2 24.2 21.8 13.4 4.5 6.6 75.0 28.6 21.4 33.5 30.0 39.4 19.6 10.0 5.3 0.0 14.5 14.9 1.6 8.1 15.1 13.1 12.3 19.6 18.4 39.4 25.3 IRAK3 IRAK-M ENSG00000090376 "Interleukin 1 receptor associated kinase 3" Q9Y616 12 66189195-66254622 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Asthma "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 78.1" "Cell type enhanced" "Detected in many" "Adipocytes: 83.3;Kupffer cells: 123.0;Macrophages: 126.3;Microglial cells: 114.3;monocytes: 96.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 5 "basophil: 12.7;classical monocyte: 23.4;intermediate monocyte: 24.2;myeloid DC: 11.5;neutrophil: 12.9;non-classical monocyte: 42.0" "Group enriched" "Detected in many" 12 "dendritic cells: 11.5;granulocytes: 12.9;monocytes: 42.0" "Cell line enhanced" "Detected in many" "ASC diff: 25.9;ASC TERT1: 21.1;HEL: 22.9;HL-60: 30.8;NB-4: 25.1;THP-1: 37.3;U-937: 26.8" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" HPA043097 Approved Approved Vesicles "Intracellular and membrane" NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 32: U-937 - Innate immune response" "Cluster 41: Macrophages - Immune response" Vesicles "HPA043097: AB_10795612" "unprognostic (7.12e-2)" "unprognostic (1.06e-1)" "unprognostic (2.90e-1)" "unprognostic (1.28e-1)" "unprognostic (1.90e-1)" "unprognostic (7.56e-3)" "unprognostic (1.49e-1)" "unprognostic (2.46e-1)" "unprognostic (7.82e-2)" "unprognostic (1.33e-1)" "unprognostic (2.95e-2)" "unprognostic (8.52e-2)" "prognostic unfavorable (6.23e-4)" "unprognostic (5.58e-2)" "unprognostic (4.64e-2)" "unprognostic (3.41e-2)" "unprognostic (3.23e-2)" 18.7 3.8 3.7 12.4 4.1 78.1 11.6 4.1 7.5 9.3 5.4 4.6 1.3 4.0 3.0 3.8 8.0 6.9 7.9 3.2 4.7 3.5 2.8 19.0 4.1 5.6 5.7 3.2 2.5 0.9 8.9 6.8 6.5 5.3 2.8 0.4 6.2 5.6 2.6 3.4 5.6 5.4 5.0 27.5 6.9 1.8 5.6 2.7 5.0 4.6 3.9 8.4 6.6 5.1 0.0 0.0 0.4 0.0 25.9 21.1 0.0 2.9 0.0 1.5 2.3 0.0 2.2 0.0 1.4 5.3 0.0 0.0 3.2 0.0 1.3 0.0 0.0 22.9 1.4 0.0 13.4 30.8 4.0 13.5 0.1 1.2 0.0 0.0 7.6 0.0 0.0 0.0 1.0 0.0 0.0 25.1 1.3 0.0 0.0 0.0 6.4 0.0 0.1 3.3 0.1 0.0 11.6 0.0 1.2 0.1 0.1 37.3 8.2 0.0 0.0 0.0 0.0 0.9 0.2 2.2 0.0 26.8 0.0 12.7 23.4 4.3 0.0 24.2 0.0 0.1 0.0 0.0 11.5 0.7 0.0 0.0 12.9 1.8 42.0 0.1 0.6 7.3 3.7 4.1 4.1 7.5 3.2 4.7 5.6 5.7 6.5 5.0 5.6 5.1 83.3 9.6 19.4 1.3 2.3 1.5 4.8 27.5 6.2 0.3 2.5 1.8 2.8 0.0 46.9 3.7 0.0 0.2 14.8 0.5 0.0 0.6 6.4 0.5 7.5 38.5 0.0 9.7 0.4 1.2 0.4 22.3 18.3 0.5 27.3 0.5 36.4 1.2 9.4 0.0 5.6 1.1 36.7 123.0 12.1 5.3 7.2 126.3 5.4 114.3 96.9 0.2 3.1 2.0 0.6 4.9 0.1 11.3 9.1 1.6 0.0 0.2 35.1 0.1 0.0 18.1 10.2 0.8 1.8 1.2 1.3 0.3 3.5 12.5 0.7 2.5 IRAK4 NY-REN-64 ENSG00000198001 "Interleukin 1 receptor associated kinase 4" Q9NWZ3 12 43758944-43789543 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Immunity, Innate immunity" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "U-937: 56.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB016685, CAB022077" Uncertain Approved Nucleoli,Microtubules,Cytosol NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 32: U-937 - Innate immune response" "Cluster 63: NK-cells & T-cells - Immune response" Microtubules "Nucleoli, Cytosol" "CAB016685: AB_1618505, CAB022077: " "unprognostic (2.76e-2)" "unprognostic (5.63e-2)" "unprognostic (1.47e-2)" "prognostic favorable (3.46e-5)" "unprognostic (6.15e-2)" "unprognostic (3.50e-3)" "unprognostic (1.44e-2)" "unprognostic (8.49e-2)" "unprognostic (6.44e-3)" "unprognostic (7.50e-2)" "unprognostic (4.00e-3)" "unprognostic (6.29e-2)" "unprognostic (4.52e-2)" "unprognostic (2.95e-1)" "unprognostic (2.31e-1)" "unprognostic (1.84e-1)" "prognostic favorable (4.42e-5)" 8.6 6.5 4.0 13.6 4.6 10.0 8.9 4.5 5.1 7.9 5.1 7.9 9.1 6.8 7.0 10.5 7.0 8.8 5.4 3.9 4.6 8.0 9.2 8.5 17.5 5.5 4.7 5.6 15.1 6.9 6.2 8.3 5.4 7.5 8.4 12.3 8.4 7.0 3.0 13.3 11.9 7.2 4.8 18.6 10.5 5.8 4.9 18.5 10.9 3.2 16.3 7.8 7.9 5.3 9.3 6.8 4.7 6.2 16.5 27.6 6.7 12.9 9.1 10.0 9.1 5.8 8.7 15.8 12.4 10.7 6.6 7.5 5.3 8.3 14.2 22.8 4.9 15.2 5.2 3.7 9.4 21.2 17.7 14.7 12.7 12.7 7.4 17.4 15.0 15.1 14.4 11.6 27.8 5.1 18.6 11.7 1.7 0.0 7.9 12.2 5.8 8.4 7.8 8.8 3.4 3.3 6.3 7.9 6.2 6.4 9.9 18.5 13.4 12.2 2.3 15.1 9.0 14.0 19.4 13.7 12.7 56.2 6.9 20.8 4.0 8.7 6.1 4.6 6.3 3.3 4.9 5.3 3.7 4.4 4.4 4.8 7.9 7.9 5.9 5.1 6.7 4.6 4.0 4.6 4.5 5.1 3.9 4.6 5.5 4.7 5.4 4.8 4.9 5.3 24.1 19.2 15.6 5.2 36.5 10.8 11.3 10.7 17.1 5.8 15.2 11.2 4.5 17.2 11.3 33.1 20.9 14.9 52.1 15.7 21.5 12.7 18.4 14.1 12.4 17.3 3.6 12.0 2.9 17.8 8.4 13.7 33.6 15.2 22.1 10.7 16.1 8.7 16.9 8.4 3.4 11.9 14.2 24.7 20.2 23.2 12.5 25.1 10.6 20.6 28.2 9.9 60.8 2.5 14.7 13.3 7.2 11.3 33.2 8.9 18.6 13.8 9.5 27.2 6.6 9.5 11.0 28.2 12.5 17.2 11.8 27.9 41.1 15.0 9.2 13.5 IRF2BP1 "DKFZP434M154, IRF-2BP1" ENSG00000170604 "Interferon regulatory factor 2 binding protein 1" Q8IU81 19 45883608-45886141 "Enzymes, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" "Repressor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in all" "NB-4: 82.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA042164, HPA049480" Approved Supported Nucleoplasm NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 35: Non-specific - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm "HPA042164: AB_2677882, HPA049480: AB_2680785" "unprognostic (5.90e-2)" "unprognostic (1.34e-1)" "unprognostic (8.86e-2)" "unprognostic (9.49e-2)" "unprognostic (1.78e-1)" "unprognostic (2.61e-2)" "unprognostic (1.62e-1)" "unprognostic (1.67e-1)" "unprognostic (3.03e-1)" "unprognostic (1.01e-1)" "prognostic favorable (2.32e-4)" "unprognostic (2.60e-1)" "prognostic favorable (3.85e-5)" "unprognostic (1.33e-2)" "unprognostic (6.99e-2)" "unprognostic (2.66e-1)" "unprognostic (5.07e-3)" 11.1 15.8 12.2 4.6 11.9 3.6 12.3 13.8 15.8 17.8 3.8 17.6 7.3 20.0 3.6 11.8 16.9 3.2 16.6 12.7 10.8 14.2 21.0 8.3 5.2 15.2 11.9 21.7 15.7 7.1 20.6 3.1 11.8 15.3 2.0 4.3 13.7 6.9 22.0 14.4 13.8 3.0 10.3 13.6 16.4 9.3 11.8 6.1 12.3 7.9 2.8 15.9 12.0 14.8 18.1 27.1 6.5 14.6 5.5 3.4 10.8 13.0 7.4 10.2 8.9 10.1 8.4 14.5 9.6 6.7 6.1 16.7 4.7 4.9 3.0 18.4 46.4 14.6 7.6 13.1 11.1 15.2 13.1 4.8 6.6 5.3 3.8 6.4 6.3 17.8 23.4 11.2 4.0 14.1 31.0 82.8 12.3 6.7 23.8 35.2 7.7 12.6 7.4 9.9 19.4 33.3 13.8 17.8 17.3 2.5 14.8 27.8 9.2 8.8 17.7 6.8 18.6 30.4 36.2 8.6 11.9 14.3 13.0 0.0 0.3 0.1 0.7 0.4 0.7 0.7 0.6 0.6 0.3 0.6 0.9 0.5 0.4 0.7 0.2 0.5 0.6 0.4 12.2 11.9 13.8 15.8 12.7 10.8 15.2 11.9 11.8 10.3 11.8 14.8 6.0 0.0 1.1 2.6 8.4 10.7 5.8 4.1 14.2 15.2 13.5 11.4 1.3 11.5 2.4 11.0 0.0 10.9 8.4 8.9 13.7 7.8 2.0 6.0 6.7 6.3 9.6 10.1 2.2 9.5 6.6 8.2 7.1 6.9 0.0 8.3 7.9 9.3 5.0 10.1 3.2 11.2 0.0 2.2 8.6 1.5 18.6 5.1 8.8 3.7 4.5 10.2 5.2 2.0 3.7 7.5 11.9 10.9 2.5 7.4 9.3 13.5 3.0 7.0 19.7 10.7 11.7 3.8 2.2 8.9 11.2 8.8 7.3 9.9 8.7 3.0 IRF2BPL "C14orf4, EAP1, KIAA1865" ENSG00000119669 "Interferon regulatory factor 2 binding protein like" Q9H1B7 14 77024543-77028708 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Transferase "Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA050862, HPA061333" Approved Enhanced Nucleoplasm NA Yes "Cluster 8: Neutrophils - Inflammatory response" "Cluster 72: Non-specific - Transcription" "Cluster 2: Karpas-707 - Immune response" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "HPA050862: AB_2681258, HPA061333: AB_2684481" "unprognostic (5.58e-2)" "unprognostic (6.48e-2)" "unprognostic (1.99e-3)" "prognostic unfavorable (5.52e-4)" "unprognostic (8.78e-3)" "unprognostic (1.57e-2)" "unprognostic (2.70e-1)" "unprognostic (1.81e-1)" "unprognostic (5.74e-2)" "unprognostic (2.53e-2)" "unprognostic (2.51e-3)" "unprognostic (5.39e-2)" "unprognostic (1.03e-3)" "unprognostic (2.55e-1)" "unprognostic (9.33e-2)" "unprognostic (1.14e-1)" "unprognostic (1.58e-2)" 26.1 25.3 12.2 9.2 13.9 5.6 28.5 13.4 12.0 20.1 12.8 32.4 6.9 25.8 5.1 13.3 33.7 6.5 22.6 14.1 21.1 28.7 19.1 20.9 6.2 15.2 14.8 32.4 17.5 19.8 22.6 7.9 10.9 18.4 3.3 7.3 19.2 10.1 16.8 25.2 15.1 8.0 12.6 19.0 18.8 13.5 19.0 9.7 18.7 4.2 3.3 26.4 18.2 9.4 15.4 13.2 32.2 36.3 9.6 8.8 45.8 15.9 13.0 4.4 5.9 6.2 24.8 5.4 11.3 13.6 12.4 23.6 5.6 11.8 3.7 25.8 19.1 6.9 13.0 8.5 12.5 1.9 29.7 11.8 9.1 7.8 6.8 34.8 6.0 10.9 10.4 59.4 5.7 42.2 21.0 14.5 14.5 6.6 68.2 4.4 9.1 13.0 15.6 22.4 24.9 36.0 22.5 23.2 42.5 8.6 16.1 3.4 10.4 20.2 19.5 6.8 10.3 22.9 26.3 9.0 31.3 4.7 25.8 1.7 1.4 1.3 2.8 1.9 2.7 1.4 2.5 2.6 1.3 1.6 2.0 2.3 9.0 5.9 2.3 10.7 2.6 0.8 12.2 13.9 13.4 12.0 14.1 21.1 15.2 14.8 10.9 12.6 19.0 9.4 71.4 22.4 14.3 5.9 40.2 73.7 32.5 22.5 115.5 57.1 54.6 41.5 19.5 32.9 11.6 64.4 29.2 22.8 58.9 10.8 37.2 19.6 1.3 25.3 26.0 44.0 47.6 10.8 8.2 19.0 49.7 47.8 12.2 25.6 26.6 15.2 55.6 60.5 33.3 10.1 8.6 14.7 16.2 54.7 78.9 4.0 30.1 26.6 35.6 9.4 10.0 57.8 38.1 8.5 4.8 17.8 7.0 34.3 21.1 30.0 6.7 23.1 13.8 10.4 39.5 56.4 83.2 1.6 50.5 54.2 50.6 46.0 39.0 27.5 12.8 20.6 ITCH AIP4 ENSG00000078747 "Itchy E3 ubiquitin protein ligase" Q96J02 20 34363241-34540748 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Antiviral defense, Apoptosis, Host-virus interaction, Immunity, Innate immunity, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 139.7;Oligodendrocytes: 260.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021126, HPA049032, CAB072824, CAB072825" Supported Enhanced Nucleoplasm,Vesicles No No "Cluster 1: Neutrophils - Mixed function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm Vesicles "CAB072824: , CAB072825: , HPA021126: AB_1851941, HPA049032: AB_2680607" "unprognostic (2.51e-1)" "unprognostic (6.95e-2)" "unprognostic (1.25e-3)" "unprognostic (3.22e-2)" "unprognostic (1.77e-1)" "unprognostic (1.13e-1)" "unprognostic (2.78e-1)" "unprognostic (9.29e-3)" "unprognostic (1.94e-1)" "unprognostic (3.89e-3)" "unprognostic (1.28e-3)" "unprognostic (1.42e-1)" "unprognostic (1.84e-2)" "unprognostic (1.30e-1)" "unprognostic (2.24e-1)" "unprognostic (3.23e-2)" "unprognostic (2.21e-1)" 19.5 16.2 13.7 18.1 27.1 27.3 20.0 19.6 17.7 24.5 17.7 21.6 20.2 19.4 16.6 42.8 15.7 17.0 20.2 14.7 15.9 23.3 55.6 18.7 21.4 19.8 20.0 18.8 16.5 23.1 7.8 25.6 21.0 19.6 23.5 25.6 18.7 19.9 17.2 14.0 20.9 21.5 15.9 20.4 20.9 38.5 20.2 23.2 26.3 21.7 25.7 30.6 14.8 45.7 55.5 34.6 35.2 25.9 38.3 57.4 42.7 43.5 52.0 56.2 54.0 101.5 83.8 26.7 42.1 55.6 73.9 66.2 54.9 92.3 66.2 20.8 17.9 78.3 28.2 59.3 43.9 32.6 34.4 31.7 46.2 44.4 72.2 49.8 41.7 40.6 45.5 45.7 46.2 26.5 49.2 18.8 16.9 35.6 44.2 40.9 76.3 63.6 34.7 91.2 21.4 16.4 82.0 32.7 51.0 33.9 38.3 31.1 39.5 61.5 36.0 42.8 33.3 36.2 40.5 40.0 41.0 21.6 38.0 4.6 6.7 7.0 12.0 7.0 12.5 9.2 4.2 6.1 4.9 7.8 3.7 5.7 20.2 7.6 4.9 14.3 5.8 4.3 13.7 27.1 19.6 17.7 14.7 15.9 19.8 20.0 21.0 15.9 20.2 45.7 26.1 12.8 21.8 56.5 33.1 15.0 23.9 11.7 25.6 19.5 15.1 8.5 25.0 12.8 25.6 31.3 25.0 17.5 46.1 28.8 5.9 12.8 59.0 26.5 34.6 20.7 12.0 26.5 85.0 16.3 21.2 24.2 33.1 36.1 19.0 17.9 18.2 53.0 15.8 15.2 72.3 16.9 10.2 24.3 26.7 139.7 22.4 31.4 26.6 68.4 30.0 38.2 43.3 79.4 260.0 22.6 23.7 15.4 50.3 25.8 21.1 26.8 23.5 26.0 13.1 21.4 22.0 40.6 25.5 30.4 16.2 46.9 30.8 12.3 11.9 40.6 ITK "EMT, LYK, PSCTK2" ENSG00000113263 "IL2 inducible T cell kinase" Q08881 5 157142933-157255185 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Adaptive immunity, Immunity" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 14 "lymphoid tissue: 57.9" "Group enriched" "Detected in some" 6 "dendritic cells: 51.7;granulocytes: 31.8;NK-cells: 42.2;Plasma cells: 34.0;T-cells: 115.7" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Group enriched" "Detected in many" 23 "gdT-cell: 39.6;MAIT T-cell: 26.4;memory CD4 T-cell: 55.6;memory CD8 T-cell: 54.9;naive CD4 T-cell: 78.2;naive CD8 T-cell: 65.0;NK-cell: 29.3;T-reg: 73.2" "Group enriched" "Detected in many" 23 "NK-cells: 29.3;T-cells: 78.2" "Group enriched" "Detected in some" 10 "JURKAT: 62.2;MOLT-4: 23.7" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA043670 Uncertain "Plasma membrane,Cytosol" NA NA "Cluster 20: T-cells - T-cell receptor" "Cluster 3: T-cells - Adaptive immune response" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 24: Non-specific - Transcription regulation" "Plasma membrane, Cytosol" "HPA043670: " "unprognostic (2.08e-3)" "unprognostic (6.57e-4)" "unprognostic (5.06e-3)" "unprognostic (4.96e-5)" "unprognostic (1.52e-2)" "unprognostic (1.12e-4)" "unprognostic (8.45e-4)" "unprognostic (1.56e-2)" "unprognostic (1.87e-2)" "unprognostic (5.99e-3)" "unprognostic (1.76e-1)" "unprognostic (2.52e-1)" "unprognostic (4.52e-6)" "unprognostic (3.64e-1)" "unprognostic (4.42e-2)" "unprognostic (1.46e-1)" "unprognostic (3.26e-2)" 1.0 0.3 0.0 15.9 0.0 3.7 0.9 0.0 0.0 1.0 0.0 1.4 0.7 0.4 0.0 1.4 0.4 4.2 0.2 0.0 0.0 0.3 1.6 3.1 29.3 0.0 0.0 0.1 0.2 0.0 0.0 0.2 0.0 0.4 1.5 0.0 0.3 0.1 0.0 0.2 4.0 0.5 0.0 10.5 3.1 0.5 0.0 57.9 0.5 0.0 24.6 3.9 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 3.9 0.0 0.0 0.0 0.0 4.5 0.0 0.0 0.0 0.0 0.0 0.0 62.2 0.0 0.0 0.0 0.0 23.7 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.1 0.0 39.6 0.0 26.4 0.0 55.6 54.9 0.1 0.0 78.2 65.0 1.3 29.3 2.3 0.1 73.2 44.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 6.2 0.0 4.0 2.7 0.6 0.0 0.0 0.0 0.4 0.4 0.9 0.0 0.6 1.8 0.0 0.1 51.7 0.1 0.0 0.1 8.5 0.2 0.3 0.8 0.0 1.7 0.2 0.0 0.0 1.1 7.7 0.4 31.8 0.1 1.8 1.0 0.0 0.0 0.2 0.0 0.0 1.6 5.1 6.7 0.0 2.9 1.8 1.0 2.8 0.0 42.2 0.0 0.1 0.0 0.0 0.0 34.0 0.3 0.0 0.4 0.0 0.0 0.0 1.0 1.0 0.0 0.0 0.2 3.4 0.1 115.7 0.0 0.1 0.6 ITPK1 ENSG00000100605 "Inositol-tetrakisphosphate 1-kinase" Q13572 14 92936914-93116320 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Isomerase, Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Proximal enterocytes: 106.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 42.9" "Group enriched" "Detected in all" 5 "granulocytes: 42.9;monocytes: 25.9" "Cell line enhanced" "Detected in all" "WM-115: 110.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA055230 Approved Approved Mitochondria NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 57: Non-specific - Angiogenesis" "Cluster 17: WM-115 - Nervous system development" "Cluster 45: Enterocytes - Digestion" Mitochondria "HPA055230: AB_2682748" "unprognostic (1.93e-3)" "unprognostic (2.50e-1)" "unprognostic (2.15e-1)" "prognostic favorable (8.56e-4)" "unprognostic (4.27e-1)" "unprognostic (2.04e-2)" "unprognostic (6.97e-2)" "unprognostic (1.32e-1)" "unprognostic (1.24e-2)" "unprognostic (2.86e-2)" "unprognostic (8.14e-2)" "unprognostic (2.27e-1)" "unprognostic (1.37e-3)" "unprognostic (2.39e-1)" "unprognostic (2.02e-1)" "unprognostic (4.20e-1)" "unprognostic (7.25e-3)" 60.0 27.2 88.3 15.5 105.9 17.3 45.3 84.7 92.7 57.0 57.2 60.1 44.4 66.8 11.6 24.8 30.3 19.4 59.2 92.5 80.7 35.6 48.3 31.6 9.0 90.2 95.8 27.1 30.7 14.8 20.6 6.8 83.0 38.8 16.4 9.3 21.0 21.7 40.9 22.2 58.5 23.4 83.2 38.1 34.2 29.5 100.4 6.9 25.4 16.1 6.6 62.5 35.0 100.7 28.1 56.6 10.3 26.3 22.5 12.6 27.8 11.8 17.5 22.9 13.8 32.8 48.9 17.7 57.4 18.6 8.7 32.5 29.6 50.3 7.2 65.9 13.1 39.2 14.6 28.5 16.8 17.9 41.5 8.2 29.5 11.6 26.3 9.9 22.8 18.0 21.9 19.8 11.3 74.6 15.5 25.5 22.0 36.4 25.5 29.1 15.1 26.3 15.5 46.3 28.0 35.5 29.6 59.0 49.5 7.8 79.5 21.7 18.0 15.9 17.3 27.0 18.9 19.3 19.1 11.4 14.6 13.8 110.8 5.3 9.8 18.2 3.2 15.4 1.9 3.3 2.0 2.1 7.0 1.0 1.2 2.2 42.9 2.4 25.9 3.5 3.0 5.1 88.3 105.9 84.7 92.7 92.5 80.7 90.2 95.8 83.0 83.2 100.4 100.7 11.8 12.8 11.1 32.0 10.8 7.4 7.5 8.3 2.8 10.2 11.8 7.6 24.3 17.2 5.1 29.5 18.8 9.7 12.9 73.5 13.7 19.2 12.7 18.1 12.5 12.4 28.8 5.9 45.1 27.3 10.0 8.9 13.3 21.2 16.5 9.2 13.9 31.3 19.4 6.7 21.6 24.8 4.1 44.7 11.8 30.3 14.9 30.5 26.6 16.9 23.2 17.2 18.6 31.7 46.5 44.6 38.7 48.2 13.2 15.2 106.6 23.0 3.3 13.7 19.7 7.4 17.8 4.3 14.3 7.0 4.4 6.8 12.7 10.3 34.5 11.0 ITPKA "IP3-3KA, IP3KA" ENSG00000137825 "Inositol-trisphosphate 3-kinase A" P23677 15 41493393-41503551 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Calmodulin-binding, Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 36.5;intestine: 18.1" "Cell type enhanced" "Detected in some" "Distal enterocytes: 51.4;Early spermatids: 45.4;Gastric mucus-secreting cells: 34.1;Late spermatids: 166.4;Proximal enterocytes: 35.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 8 "MAIT T-cell: 1.4" "Lineage enriched" "Detected in single" 11 "T-cells: 1.4" "Cell line enhanced" "Detected in many" "Hep G2: 33.6;OE19: 18.2" "Low region specificity" "Detected in all" HPA040454 Enhanced Approved Approved "Vesicles,Plasma membrane" No No "Cluster 16: MAIT-cells - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 31: Spermatids - Spermatogenesis" Vesicles "Plasma membrane" "HPA040454: AB_10672897" "unprognostic (5.91e-2)" "unprognostic (2.16e-3)" "unprognostic (4.19e-1)" "unprognostic (3.57e-3)" "prognostic unfavorable (6.77e-4)" "unprognostic (2.25e-2)" "unprognostic (2.69e-2)" "unprognostic (1.01e-1)" "unprognostic (3.58e-1)" "unprognostic (1.28e-1)" "unprognostic (1.21e-1)" "unprognostic (2.06e-1)" "prognostic unfavorable (3.76e-9)" "unprognostic (2.15e-1)" "unprognostic (2.87e-1)" "unprognostic (1.12e-3)" "unprognostic (2.10e-2)" 0.2 7.3 21.4 0.7 26.7 0.4 0.2 13.8 36.5 1.3 10.9 10.7 17.6 0.3 0.1 0.3 0.5 0.2 2.6 28.7 12.4 0.2 1.7 0.5 0.1 10.9 12.0 0.3 1.9 2.0 0.4 0.3 11.6 0.8 2.7 0.3 1.4 0.3 4.4 0.4 18.1 0.3 11.3 0.2 10.9 10.4 12.1 0.0 0.2 0.0 0.0 0.6 0.9 20.4 7.1 1.9 0.3 7.9 0.0 2.5 14.3 4.3 3.4 2.8 2.9 16.3 0.3 0.0 3.5 0.4 6.3 0.8 3.4 0.3 0.2 6.6 4.3 9.9 4.7 33.6 12.6 3.4 0.5 0.2 0.2 2.7 0.8 1.6 0.2 1.3 12.9 1.9 1.0 4.7 0.3 6.5 0.9 18.2 5.6 1.7 1.4 0.6 0.3 0.4 0.7 1.5 3.2 0.0 0.3 0.0 0.9 5.0 0.3 6.9 7.1 7.7 11.8 1.0 10.8 0.0 12.6 13.2 2.3 0.0 0.0 0.0 0.1 0.0 1.4 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 21.4 26.7 13.8 36.5 28.7 12.4 10.9 12.0 11.6 11.3 12.1 20.4 0.1 0.0 0.0 3.3 0.5 0.1 0.3 0.1 0.0 0.0 0.3 0.0 1.4 0.0 0.1 0.0 0.0 0.6 0.1 51.4 0.0 0.1 45.4 0.3 2.4 0.5 0.0 0.8 23.7 0.7 0.5 0.3 34.1 0.3 0.0 1.0 0.4 0.3 0.2 0.0 0.8 12.0 0.0 0.0 0.0 166.4 2.5 0.4 0.0 1.9 0.0 7.9 0.0 1.5 2.9 0.8 16.1 1.5 0.1 0.1 35.8 0.1 0.1 0.2 6.6 0.3 0.5 14.4 4.9 0.0 0.0 0.1 0.4 0.1 18.7 0.2 ITPKB "IP3-3KB, IP3KB" ENSG00000143772 "Inositol-trisphosphate 3-kinase B" P27987 1 226631690-226739323 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Calmodulin-binding, Kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 211.8;choroid plexus: 123.3" "Cell type enhanced" "Detected in many" "Adipocytes: 70.5;Astrocytes: 225.3;Microglial cells: 58.1;Oligodendrocytes: 110.6" "Cancer enhanced" "Detected in all" "melanoma: 44.3" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "SK-MEL-30: 47.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030273, HPA072923" Enhanced Approved Nucleoplasm NA NA 39000 "Cluster 49: Eosinophils - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 64: Astrocytes - Nervous system maintenance" Nucleoplasm "HPA030273: AB_10601127, HPA072923: AB_2686558" "unprognostic (4.54e-2)" "unprognostic (3.85e-2)" "unprognostic (8.41e-3)" "unprognostic (9.37e-3)" "unprognostic (1.53e-1)" "prognostic favorable (1.72e-5)" "unprognostic (1.24e-1)" "prognostic favorable (6.65e-4)" "unprognostic (2.29e-1)" "unprognostic (9.57e-2)" "unprognostic (1.41e-2)" "unprognostic (1.75e-2)" "unprognostic (3.23e-3)" "unprognostic (2.90e-2)" "unprognostic (7.46e-2)" "unprognostic (6.54e-3)" "unprognostic (7.87e-2)" 29.6 4.5 148.6 15.6 205.6 19.0 19.6 152.0 104.8 28.0 123.3 45.3 6.6 48.8 17.0 14.0 27.0 10.0 16.2 109.0 149.5 15.1 3.2 22.5 29.0 211.8 188.0 9.5 5.8 7.1 6.8 15.9 169.1 14.5 6.7 0.6 30.2 22.7 12.4 19.4 24.9 31.7 154.6 23.5 21.2 3.7 207.6 33.2 8.3 12.3 20.3 38.6 15.6 133.7 4.7 5.0 7.9 9.1 6.1 3.9 2.1 1.2 5.5 2.5 5.7 0.7 5.8 21.6 7.4 1.2 0.5 6.8 10.1 4.1 1.2 3.0 6.9 9.6 5.5 0.0 2.3 8.8 16.4 4.4 5.9 2.8 2.5 6.9 17.2 10.8 0.1 2.9 0.3 4.5 16.7 12.1 17.3 3.5 8.0 6.4 14.2 4.8 18.2 7.5 4.6 6.0 3.8 2.8 47.2 7.7 11.7 10.1 12.0 3.2 2.4 2.9 7.6 0.2 8.0 25.8 0.8 8.0 12.1 0.9 0.9 5.4 2.6 1.3 2.3 1.2 3.2 2.7 0.6 1.8 4.7 3.5 3.4 2.1 2.5 0.5 1.9 2.0 148.6 205.6 152.0 104.8 109.0 149.5 211.8 188.0 169.1 154.6 207.6 133.7 70.5 0.0 7.4 225.3 16.0 12.2 4.8 3.1 7.4 0.3 7.0 5.3 8.5 1.5 4.5 7.3 0.0 0.6 28.9 1.2 3.9 2.2 2.8 4.7 6.8 42.2 4.2 5.2 2.4 2.4 2.3 8.9 3.6 4.5 10.1 21.8 27.8 1.0 19.8 0.0 6.9 2.8 2.0 16.0 38.0 22.9 7.2 14.4 19.6 58.1 10.2 1.2 28.8 10.6 110.6 2.7 3.7 9.4 11.8 5.1 2.0 0.6 2.6 0.1 0.0 5.9 16.3 0.9 4.7 5.3 10.1 0.4 35.2 3.7 3.1 2.7 ITPKC "IP3-3KC, IP3KC" ENSG00000086544 "Inositol-trisphosphate 3-kinase C" Q96DU7 19 40717112-40740860 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Calmodulin-binding, Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "esophagus: 96.7" "Cell type enhanced" "Detected in many" "Gastric mucus-secreting cells: 151.4;Glandular and luminal cells: 139.3;Squamous epithelial cells: 160.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "hTCEpi: 46.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA050760, HPA053003" Approved Supported "Nuclear speckles" No No "Cluster 10: Basophils - Unknown function" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 44: Endometrium - Transcription" "Nuclear speckles" "HPA050760: AB_2681227, HPA053003: AB_2682011" "unprognostic (4.27e-2)" "unprognostic (3.73e-2)" "unprognostic (8.31e-2)" "unprognostic (9.12e-3)" "unprognostic (1.10e-2)" "unprognostic (9.81e-2)" "unprognostic (6.06e-2)" "prognostic unfavorable (4.91e-4)" "unprognostic (1.48e-1)" "unprognostic (1.54e-3)" "unprognostic (1.84e-3)" "unprognostic (2.63e-1)" "unprognostic (2.59e-1)" "unprognostic (1.70e-1)" "unprognostic (2.86e-2)" "unprognostic (3.45e-2)" "unprognostic (3.32e-1)" 45.3 13.9 11.2 10.8 9.6 3.5 29.4 9.4 10.7 32.6 11.6 16.8 11.7 18.6 4.7 96.7 25.0 23.0 19.3 10.0 10.7 18.8 17.7 41.8 6.0 15.0 11.5 12.9 22.8 10.3 22.0 10.3 11.6 27.1 6.8 5.5 31.1 10.5 18.4 51.0 16.9 16.3 10.8 14.5 26.3 6.0 15.2 8.7 17.2 8.9 13.9 22.4 42.0 9.3 12.9 12.0 7.3 11.5 32.2 27.8 11.6 7.5 15.7 7.6 6.7 17.3 13.1 3.5 8.5 9.7 5.7 13.3 7.3 32.6 3.1 6.7 7.5 2.7 4.5 12.3 31.8 3.0 3.6 38.8 46.4 7.2 26.5 10.3 18.9 5.0 10.6 6.1 7.5 15.7 4.4 4.5 3.7 29.4 5.4 4.7 3.6 4.9 12.0 21.5 5.2 6.5 7.6 30.5 7.2 8.4 14.1 7.6 12.2 4.9 7.3 3.3 5.1 3.5 0.9 3.7 7.6 3.1 5.4 0.9 0.7 0.4 0.8 0.3 0.3 0.3 0.6 0.4 0.3 0.7 0.4 0.5 0.3 0.2 0.5 0.5 0.6 0.4 11.2 9.6 9.4 10.7 10.0 10.7 15.0 11.5 11.6 10.8 15.2 9.3 75.4 86.6 35.2 6.5 2.7 60.4 72.4 17.4 39.9 10.0 88.4 44.4 4.1 7.2 29.7 3.7 0.0 7.7 2.8 57.7 1.9 13.9 2.1 67.5 23.2 26.4 16.7 3.2 7.4 12.3 5.5 20.1 151.4 139.3 3.8 4.3 25.7 6.8 2.9 5.0 6.0 27.2 2.0 7.8 9.6 2.2 11.8 6.8 19.6 6.5 3.1 3.7 3.1 9.0 3.5 23.2 50.8 7.5 1.2 65.3 28.7 4.4 29.4 6.2 0.0 7.1 10.1 1.9 2.0 160.8 53.4 16.8 5.2 4.6 18.0 98.6 JADE2 "JADE-2, KIAA0239, PHF15" ENSG00000043143 "Jade family PHD finger 2" Q9NQC1 5 134524312-134583230 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA025959, HPA055789" Uncertain Enhanced Nucleoplasm NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 64: Macrophages - Immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 24: Non-specific - Transcription regulation" Nucleoplasm "HPA025959: AB_1855289, HPA055789: AB_2682922" "unprognostic (8.98e-2)" "unprognostic (1.38e-1)" "unprognostic (1.10e-2)" "unprognostic (1.29e-1)" "unprognostic (3.46e-2)" "unprognostic (2.14e-1)" "unprognostic (7.69e-2)" "unprognostic (5.56e-2)" "unprognostic (8.25e-2)" "prognostic unfavorable (4.42e-4)" "unprognostic (1.58e-2)" "unprognostic (3.49e-2)" "prognostic favorable (5.36e-6)" "unprognostic (3.73e-1)" "unprognostic (1.76e-3)" "unprognostic (2.68e-1)" "unprognostic (2.87e-2)" 16.1 20.1 11.8 15.2 16.5 9.8 13.7 10.3 14.0 16.3 1.1 14.5 10.2 12.9 6.4 9.7 16.1 10.7 12.1 11.2 16.0 11.9 5.5 13.8 26.8 14.4 12.8 23.9 13.3 20.4 13.1 7.1 13.9 13.0 6.2 8.9 14.5 14.1 12.7 12.0 18.4 9.8 9.8 21.8 12.7 6.8 13.9 15.8 16.2 8.5 16.2 17.9 11.6 15.7 66.6 46.2 1.3 2.0 13.8 18.5 19.6 10.7 28.9 21.0 26.4 35.2 50.4 75.2 24.7 13.4 21.3 13.0 6.4 60.8 8.2 44.2 2.3 18.0 30.0 7.7 17.5 19.2 2.5 11.8 27.3 26.3 29.5 14.5 15.1 21.4 10.5 24.4 13.1 26.4 35.6 18.5 14.7 19.5 23.9 29.9 1.2 29.8 19.9 18.1 9.0 5.6 30.2 0.8 42.2 11.4 12.1 25.3 22.5 13.9 12.7 43.2 30.1 10.6 49.7 68.3 24.1 34.1 22.6 0.9 0.6 2.0 3.2 0.6 3.4 3.8 3.1 3.1 1.1 2.3 3.0 3.1 0.7 1.9 1.6 0.5 3.1 1.3 11.8 16.5 10.3 14.0 11.2 16.0 14.4 12.8 13.9 9.8 13.9 15.7 13.6 9.6 11.2 4.2 35.1 4.2 7.0 6.5 21.6 24.4 10.3 7.1 13.3 12.8 6.0 7.3 35.5 7.3 41.0 7.7 7.9 5.5 0.6 4.6 5.4 12.5 11.5 4.6 15.3 16.9 9.7 10.2 5.6 3.6 2.5 16.0 18.2 3.5 4.2 10.1 16.0 8.8 6.1 30.5 15.7 0.8 20.5 12.1 1.8 5.6 19.4 7.4 42.2 9.0 16.5 8.8 4.9 19.2 22.4 4.6 13.8 10.4 9.5 22.9 0.0 6.7 11.6 0.3 3.3 6.0 3.7 7.3 35.0 4.2 10.7 4.3 JAK1 "JAK1A, JAK1B, JTK3" ENSG00000162434 "Janus kinase 1" P23458 1 64833229-65067754 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "NK-cells: 700.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "ASC diff: 336.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB013088 Approved NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 16: Immune cells - Immune response" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 63: NK-cells & T-cells - Immune response" "CAB013088: " "prognostic favorable (9.63e-4)" "unprognostic (1.24e-1)" "prognostic favorable (2.81e-4)" "unprognostic (5.10e-2)" "unprognostic (1.16e-1)" "unprognostic (4.21e-2)" "unprognostic (1.53e-1)" "unprognostic (7.00e-3)" "unprognostic (8.40e-2)" "unprognostic (7.88e-3)" "unprognostic (1.66e-2)" "unprognostic (8.84e-2)" "prognostic favorable (2.67e-4)" "unprognostic (2.35e-1)" "unprognostic (2.04e-1)" "unprognostic (7.30e-2)" "unprognostic (3.51e-1)" 99.6 38.2 44.8 73.9 42.6 51.4 60.7 46.7 45.4 58.2 61.7 50.5 33.9 56.7 60.8 38.7 40.7 64.2 49.5 46.0 53.9 55.4 86.6 62.1 110.1 56.0 47.0 77.1 46.7 55.0 35.6 57.0 49.1 42.2 54.5 41.7 34.2 55.2 83.4 79.2 50.8 64.2 44.0 88.3 49.5 46.8 59.8 103.8 45.0 118.6 101.7 81.2 39.3 45.5 50.4 66.2 27.7 3.0 336.8 177.2 35.1 76.3 116.1 64.6 75.7 21.4 27.7 76.5 59.1 142.8 118.7 27.8 19.4 63.6 93.8 102.7 29.5 104.0 32.1 56.2 126.6 40.2 68.4 159.9 92.6 97.2 103.0 78.4 208.7 37.0 37.9 78.9 80.1 31.2 22.3 39.6 18.6 65.3 37.4 30.5 77.8 28.5 213.8 84.9 19.8 57.9 107.4 51.6 52.9 56.6 104.3 28.6 180.8 74.7 34.1 174.2 42.0 47.7 23.6 60.4 70.5 57.9 34.1 162.4 52.1 146.8 94.0 66.3 105.7 89.1 90.2 100.7 69.4 73.1 97.0 80.6 177.9 305.4 76.2 55.0 117.1 130.8 44.8 42.6 46.7 45.4 46.0 53.9 56.0 47.0 49.1 44.0 59.8 45.5 211.2 51.3 94.9 62.3 219.8 116.6 150.7 91.3 78.0 37.0 66.2 71.6 112.8 87.2 84.2 112.2 22.9 9.0 345.0 89.2 43.0 171.3 125.2 90.1 167.0 183.0 66.4 52.8 59.6 213.8 105.2 131.9 91.3 151.2 57.0 48.7 174.2 91.4 58.5 21.9 85.3 62.0 69.2 160.2 148.9 101.7 96.0 177.9 49.8 80.6 234.8 53.5 700.3 61.3 42.7 217.5 58.6 84.7 175.2 183.8 53.7 79.0 61.9 38.6 164.3 70.6 191.8 40.8 53.1 71.2 166.1 12.2 256.0 95.7 47.6 200.1 JAK2 JTK10 ENSG00000096968 "Janus kinase 2" O60674 9 4984390-5129948 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Adaptive immunity, Immunity, Innate immunity" "Chromatin regulator, Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 93.4;Inhibitory neurons: 122.3;Microglial cells: 106.8;Oligodendrocyte precursor cells: 69.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 132.5" "Lineage enriched" "Detected in all" 5 "granulocytes: 132.5" "Group enriched" "Detected in many" 5 "ASC diff: 42.2;HDLM-2: 75.0;HEL: 154.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB013089, HPA040820, HPA043870" Approved Supported "Nucleoplasm,Plasma membrane,Focal adhesion sites" No No "Cluster 46: Basophils - DNA binding" "Cluster 16: Immune cells - Immune response" "Cluster 36: HEL - Hemostasis" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "Plasma membrane, Focal adhesion sites" "CAB013089: AB_2533647, HPA040820: AB_2677151, HPA043870: AB_2678708" "unprognostic (2.24e-3)" "unprognostic (2.76e-2)" "unprognostic (1.50e-2)" "unprognostic (7.67e-2)" "unprognostic (5.50e-2)" "unprognostic (3.09e-2)" "unprognostic (1.48e-1)" "unprognostic (7.36e-2)" "unprognostic (1.09e-1)" "unprognostic (5.49e-3)" "unprognostic (1.58e-1)" "unprognostic (1.72e-2)" "unprognostic (3.85e-1)" "unprognostic (4.53e-2)" "unprognostic (3.43e-2)" "unprognostic (1.96e-1)" "unprognostic (7.37e-3)" 15.6 7.6 3.2 19.2 3.7 21.7 8.9 6.3 9.1 8.5 1.1 6.7 6.5 11.3 8.6 8.8 8.0 10.5 24.5 2.7 3.1 6.8 4.5 10.9 18.2 3.3 1.8 11.5 3.8 6.5 2.9 11.0 2.0 6.8 6.5 12.8 4.0 6.2 9.8 11.2 7.7 9.5 3.5 17.6 13.4 9.8 1.7 7.5 4.8 8.9 12.7 11.7 9.1 3.9 6.8 3.7 3.7 6.3 42.2 12.4 1.1 9.1 8.6 7.2 4.6 1.2 2.0 0.3 2.1 5.4 5.4 2.3 4.4 5.1 4.9 75.0 1.4 154.7 7.6 1.7 10.0 10.5 7.1 9.5 2.1 2.8 4.5 7.6 6.6 5.1 10.9 17.4 11.6 2.2 2.9 12.8 3.3 3.3 4.3 5.1 8.2 2.2 4.7 3.5 4.2 2.4 2.6 3.5 2.8 3.6 2.0 15.4 13.1 10.2 3.6 10.7 6.4 3.1 6.4 1.5 13.6 4.7 5.3 132.5 20.5 38.2 5.6 20.1 4.5 5.6 4.1 3.1 26.5 4.9 2.2 2.8 19.2 9.6 16.4 9.7 4.5 7.7 3.2 3.7 6.3 9.1 2.7 3.1 3.3 1.8 2.0 3.5 1.7 3.9 14.3 16.0 7.9 31.6 12.9 9.7 3.3 4.9 10.8 8.0 5.2 3.4 30.0 0.0 6.7 7.3 8.4 1.9 13.9 11.7 1.9 3.3 8.6 5.1 11.2 9.4 3.0 19.8 93.4 3.9 0.9 8.9 38.7 5.6 14.0 11.4 4.6 1.9 14.2 8.4 122.3 4.5 0.0 33.6 28.8 7.1 23.6 38.9 5.4 106.8 49.5 12.6 8.2 69.9 42.3 7.0 20.9 33.4 10.7 3.0 3.9 3.3 7.1 11.2 0.0 9.7 12.5 15.0 5.5 11.6 8.4 3.4 10.4 5.1 4.1 4.5 JAK3 "JAK-3, JAK3_HUMAN, JAKL, L-JAK, LJAK" ENSG00000105639 "Janus kinase 3" P52333 19 17824780-17848071 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Adaptive immunity, Immunity, Innate immunity" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, SCID" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 55.1" "Cell type enhanced" "Detected in many" "B-cells: 27.8;dendritic cells: 20.1;Macrophages: 17.9;NK-cells: 18.6;Plasma cells: 18.4;T-cells: 37.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in some" "HDLM-2: 35.7;HEL: 15.9;HMC-1: 15.5;Karpas-707: 40.2;U-266/70: 15.4;U-266/84: 24.7;U-937: 24.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA070314 Enhanced Approved "Plasma membrane,Cytosol" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 2: Immune cells - Immune response" "Cluster 2: Karpas-707 - Immune response" "Cluster 58: T-cells - T-cell receptor" "Plasma membrane, Cytosol" "HPA070314: AB_2686251" "unprognostic (5.59e-3)" "prognostic favorable (6.42e-5)" "unprognostic (5.71e-2)" "unprognostic (2.34e-1)" "unprognostic (6.13e-3)" "unprognostic (1.11e-3)" "unprognostic (4.21e-2)" "unprognostic (2.60e-1)" "unprognostic (2.38e-2)" "unprognostic (2.36e-1)" "unprognostic (3.58e-2)" "unprognostic (1.94e-1)" "prognostic unfavorable (2.89e-14)" "unprognostic (2.28e-1)" "unprognostic (2.21e-2)" "unprognostic (4.43e-2)" "unprognostic (7.61e-2)" 6.7 2.5 4.0 36.3 4.4 18.6 4.0 3.9 5.6 3.3 3.7 4.0 3.0 2.2 2.4 2.8 5.3 4.8 3.2 4.1 6.7 6.2 2.9 13.1 40.5 7.3 6.1 15.5 1.8 1.9 3.1 5.7 6.4 4.4 3.1 0.6 3.5 1.9 0.7 1.7 15.4 3.5 5.5 55.1 4.6 2.6 6.6 11.3 4.9 0.9 29.7 7.4 3.1 6.1 0.2 0.6 0.5 1.8 0.6 2.4 0.4 0.8 0.0 0.1 0.1 0.0 1.6 0.7 3.3 0.7 0.4 0.2 0.0 0.4 0.0 35.7 0.0 15.9 0.1 1.5 1.2 0.0 15.5 8.4 0.5 0.1 0.0 0.1 0.3 3.6 0.1 40.2 0.0 0.7 6.5 0.0 0.3 0.9 1.3 8.2 0.0 0.7 0.8 0.0 0.0 0.6 0.2 0.4 0.1 0.2 3.5 2.4 0.7 0.0 0.7 0.0 0.0 15.4 24.7 4.3 0.1 24.2 0.3 2.0 7.5 0.3 17.8 14.6 20.2 9.4 21.1 18.6 6.8 10.3 20.2 18.5 25.1 13.4 14.2 5.5 18.0 12.4 4.0 4.4 3.9 5.6 4.1 6.7 7.3 6.1 6.4 5.5 6.6 6.1 5.5 0.0 4.6 2.3 27.8 0.8 0.6 0.5 0.6 0.6 0.5 0.8 1.9 0.0 1.0 1.8 0.0 1.1 20.1 0.0 0.0 0.5 1.0 0.3 2.1 8.0 0.0 6.1 4.3 0.4 0.8 4.6 2.0 0.4 5.1 0.8 9.7 0.4 14.5 0.0 2.6 0.0 0.0 9.2 1.9 2.0 12.5 17.9 3.6 4.7 16.6 0.9 18.6 0.0 0.4 0.5 0.0 14.7 18.4 0.5 0.0 0.3 0.9 0.7 6.6 0.3 2.9 0.3 0.7 0.3 1.0 1.4 37.7 14.8 0.1 0.6 KALRN "ARHGEF24, DUET, duo, HAPIP, Hs.8004, Kalirin, TRAD" ENSG00000160145 "Kalirin RhoGEF kinase" O60229 3 124080023-124726325 "Cancer-related genes, Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Guanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 31.3" "Group enriched" "Detected in many" 5 "Excitatory neurons: 1434.2;Inhibitory neurons: 480.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in single" "T-reg: 1.6" "Lineage enriched" "Detected in single" 5 "T-cells: 1.6" "Cell line enhanced" "Detected in many" "CACO-2: 57.4;HEL: 35.3;OE19: 20.1;SH-SY5Y: 15.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA011913, CAB026456" Approved Approved Nucleoplasm,Cytosol NA NA 83000 "Cluster 35: T-regs - Unknown function" "Cluster 47: Non-specific - Unknown function" "Cluster 39: CACO-2 - Unknown function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoplasm, Cytosol" "CAB026456: , HPA011913: AB_1850494" "unprognostic (2.54e-2)" "unprognostic (3.43e-1)" "unprognostic (2.08e-1)" "unprognostic (3.12e-4)" "unprognostic (2.54e-1)" "unprognostic (1.74e-1)" "unprognostic (1.52e-1)" "unprognostic (1.53e-1)" "unprognostic (3.41e-2)" "unprognostic (8.58e-2)" "unprognostic (1.65e-1)" "unprognostic (1.04e-1)" "unprognostic (2.26e-3)" "unprognostic (5.58e-2)" "unprognostic (2.67e-1)" "unprognostic (3.70e-2)" "unprognostic (2.81e-3)" 9.4 6.3 15.0 2.2 23.4 0.3 6.7 0.0 31.3 9.1 4.9 2.0 2.5 7.7 1.9 9.5 4.6 2.9 12.8 21.3 3.4 3.8 5.8 4.4 0.9 0.0 6.6 3.1 8.8 3.5 4.1 4.2 0.0 2.8 1.8 4.5 2.8 4.9 27.2 2.0 2.0 6.2 0.0 8.5 12.1 2.6 10.7 0.5 5.1 19.3 1.6 2.6 6.0 20.9 0.7 1.1 6.2 1.3 0.9 0.2 8.1 2.5 1.5 2.4 1.1 57.4 4.5 0.2 0.8 6.4 3.9 0.4 1.4 0.0 2.0 0.0 0.7 35.3 0.4 8.9 0.1 0.0 0.0 0.4 0.0 0.5 0.1 2.6 2.9 0.1 8.3 0.2 0.7 4.2 0.0 0.0 3.5 20.1 5.4 1.8 2.8 0.0 0.2 0.5 2.1 15.9 0.7 0.5 0.5 6.0 1.2 0.1 14.4 7.0 2.8 1.0 1.1 0.0 0.6 0.0 0.8 0.0 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.0 0.0 0.7 0.2 0.2 0.0 0.0 0.0 1.6 0.4 15.0 23.4 0.0 31.3 21.3 3.4 0.0 6.6 0.0 0.0 10.7 20.9 56.2 3.2 3.9 191.3 0.6 1.7 1.5 0.3 0.6 61.2 6.1 7.1 32.1 18.6 0.5 16.5 6.2 8.0 2.5 40.5 1.9 5.0 57.0 15.0 18.8 23.2 9.6 5.3 1434.2 8.4 1.7 5.9 29.0 7.4 3.8 4.4 45.3 21.7 1.0 0.0 480.8 16.4 0.0 1.6 1.1 64.0 3.7 5.3 3.6 48.7 0.0 4.7 8.2 162.3 63.1 4.4 21.0 33.1 0.3 2.6 34.8 3.6 8.4 2.7 19.7 8.8 21.8 5.2 2.6 4.9 1.1 14.2 1.0 17.5 12.3 1.6 KAT2A "GCN5, GCN5L2, PCAF-b" ENSG00000108773 "Lysine acetyltransferase 2A" Q92830 17 42113111-42121367 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Host-virus interaction, Transcription, Transcription regulation" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 84.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA048958 Uncertain NA NA "Cluster 30: Non-specific - Translation" "Cluster 72: Non-specific - Transcription" "Cluster 21: OE19 - Mitochondria" "Cluster 52: Non-specific - Transcription" "HPA048958: AB_2680571" "unprognostic (1.71e-1)" "unprognostic (9.08e-2)" "unprognostic (1.66e-1)" "unprognostic (2.31e-1)" "unprognostic (3.41e-1)" "unprognostic (9.07e-2)" "unprognostic (1.91e-3)" "unprognostic (3.87e-2)" "unprognostic (2.53e-1)" "unprognostic (1.09e-1)" "prognostic favorable (3.57e-4)" "unprognostic (2.78e-2)" "prognostic unfavorable (1.41e-8)" "unprognostic (3.97e-2)" "unprognostic (2.90e-1)" "unprognostic (1.89e-1)" "unprognostic (2.29e-3)" 14.1 20.8 11.3 6.5 11.9 4.2 13.2 7.7 18.9 20.3 3.1 15.4 6.7 17.2 1.7 14.7 21.0 3.1 10.1 10.8 12.7 13.1 15.7 9.7 5.3 10.8 10.4 28.4 16.9 5.8 14.4 4.6 10.0 16.9 4.0 1.0 10.0 4.3 11.8 15.9 13.5 3.4 5.3 17.4 13.0 10.8 14.0 4.7 14.6 2.1 4.6 15.5 16.4 12.4 24.7 46.6 6.8 25.3 9.3 7.6 29.7 15.7 8.3 34.0 16.7 31.9 19.5 48.1 38.6 12.1 25.6 36.0 27.9 25.0 12.1 27.0 58.0 12.0 29.8 28.8 9.7 32.3 30.8 9.0 20.8 19.1 11.9 9.2 13.8 11.9 30.7 8.9 9.1 26.4 77.7 23.5 14.5 60.9 0.0 18.3 13.3 31.9 9.2 24.4 32.4 14.2 16.8 36.2 13.2 5.1 26.9 15.3 10.7 17.1 17.4 25.1 28.2 23.8 24.5 26.9 12.5 27.5 9.7 0.0 0.1 0.0 0.2 0.0 0.4 0.5 0.5 0.6 0.4 0.3 0.6 0.1 0.0 0.1 0.0 0.1 0.0 0.2 11.3 11.9 7.7 18.9 10.8 12.7 10.8 10.4 10.0 5.3 14.0 12.4 21.5 12.8 11.5 84.5 19.0 12.2 12.6 6.8 26.2 16.5 18.9 22.7 7.1 18.6 6.6 18.4 10.4 25.1 10.7 7.9 3.9 9.2 1.3 5.9 11.3 18.4 15.7 6.7 39.6 8.0 20.5 12.1 17.3 8.2 11.4 25.8 22.5 20.2 12.1 10.1 41.0 10.1 6.1 10.9 6.8 3.7 32.6 9.8 7.2 32.8 5.2 3.7 5.2 41.7 28.3 6.7 7.3 29.0 7.2 10.9 4.0 4.1 5.4 7.8 13.1 15.1 10.8 5.2 18.2 18.7 13.9 11.2 7.8 26.4 20.2 9.1 KAT2B "GCN5, GCN5L, P/CAF, PCAF" ENSG00000114166 "Lysine acetyltransferase 2B" Q92831 3 20040446-20154404 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Biological rhythms, Cell cycle, Host-virus interaction, Transcription, Transcription regulation" "Activator, Acyltransferase, Transferase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 165.2;Oligodendrocyte precursor cells: 418.2;Oligodendrocytes: 175.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002470, CAB004526, HPA055839, HPA073897" Supported Enhanced Nucleoplasm,Cytosol NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 68: Oligodendrocytes - Mixed function" Nucleoplasm Cytosol "CAB004526: AB_2128417, HPA002470: , HPA055839: AB_2682938, HPA073897: " "unprognostic (2.91e-2)" "unprognostic (6.85e-3)" "unprognostic (9.05e-2)" "unprognostic (2.25e-1)" "unprognostic (2.66e-2)" "unprognostic (3.01e-3)" "unprognostic (2.44e-1)" "unprognostic (3.83e-3)" "unprognostic (2.44e-2)" "unprognostic (1.03e-1)" "unprognostic (5.23e-3)" "unprognostic (7.13e-2)" "unprognostic (7.03e-2)" "unprognostic (2.26e-2)" "unprognostic (1.59e-1)" "unprognostic (5.16e-2)" "unprognostic (4.63e-2)" 17.9 9.9 38.7 15.4 46.5 48.0 10.3 39.1 40.3 14.9 33.8 13.8 17.7 12.3 8.1 27.4 11.7 12.6 35.9 34.4 42.2 16.6 39.3 16.2 22.4 41.7 44.9 27.7 18.7 51.0 10.2 13.7 43.0 14.5 12.5 33.9 37.6 13.0 60.2 14.3 21.5 13.6 37.1 19.8 13.9 2.7 42.2 23.6 14.4 56.1 20.1 11.9 15.1 45.1 2.7 6.9 3.8 6.2 15.1 14.2 8.8 8.8 13.0 9.1 13.3 2.1 4.5 24.0 3.6 16.7 11.5 2.0 9.4 2.8 7.6 21.8 9.0 21.0 10.7 0.7 7.1 3.2 26.2 6.1 5.0 7.9 5.1 16.0 8.8 5.8 13.7 32.9 13.0 3.3 7.0 6.4 1.6 6.7 6.8 9.1 7.1 5.1 12.4 14.2 1.9 4.1 4.9 7.9 30.5 5.9 8.2 14.2 8.5 15.3 6.1 5.8 10.1 12.3 27.6 5.7 13.9 13.8 33.0 0.6 0.4 1.3 1.5 0.7 1.5 0.4 1.3 1.1 0.4 0.8 0.4 0.8 2.4 0.5 0.5 1.2 2.2 0.3 38.7 46.5 39.1 40.3 34.4 42.2 41.7 44.9 43.0 37.1 42.2 45.1 15.5 32.1 20.8 165.2 11.9 8.5 11.3 2.2 3.4 14.6 5.5 5.0 64.1 4.3 10.4 5.5 4.2 7.3 19.5 16.6 11.7 3.8 3.8 6.4 5.7 14.6 11.5 52.2 22.4 4.4 1.1 11.7 3.6 13.1 10.8 12.3 20.7 33.6 7.7 15.2 32.1 7.3 4.1 22.8 23.3 1.8 6.5 16.0 17.8 52.5 11.1 14.8 14.4 418.2 175.4 3.3 2.4 5.3 19.9 7.1 24.7 6.2 12.7 11.9 6.6 25.2 9.0 0.8 1.4 10.0 12.9 9.9 23.5 2.9 3.8 8.0 KAT5 "cPLA2, ESA1, HTATIP, HTATIP1, PLIP, TIP60, ZC2HC5" ENSG00000172977 "Lysine acetyltransferase 5" Q92993 11 65711996-65719604 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Transcription factors" "Growth regulation, Host-virus interaction, Transcription, Transcription regulation" "Activator, Acyltransferase, Chromatin regulator, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016953, HPA074328" Approved Supported Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Nucleoplasm "Vesicles, Cytosol" "HPA016953: AB_1851277, HPA074328: " "unprognostic (2.20e-1)" "unprognostic (3.58e-1)" "unprognostic (3.59e-2)" "unprognostic (2.74e-1)" "unprognostic (9.61e-2)" "unprognostic (7.16e-2)" "unprognostic (1.29e-3)" "unprognostic (1.20e-1)" "unprognostic (2.01e-1)" "unprognostic (2.74e-1)" "unprognostic (2.13e-1)" "unprognostic (2.54e-1)" "prognostic favorable (1.10e-13)" "unprognostic (1.37e-1)" "unprognostic (2.55e-1)" "unprognostic (1.85e-1)" "unprognostic (8.54e-2)" 31.6 30.0 38.7 23.8 41.0 52.9 32.1 41.7 48.8 39.5 38.6 43.6 21.6 45.1 33.7 34.9 44.9 20.5 32.4 37.9 38.9 32.9 26.3 29.5 28.0 40.0 39.5 39.2 32.7 45.6 33.7 29.9 41.2 33.1 27.0 31.0 29.6 36.3 42.8 47.6 32.2 35.2 40.0 34.3 35.9 45.2 39.9 39.3 38.2 34.6 30.2 39.5 34.8 43.8 37.2 44.1 40.1 29.6 31.3 32.7 41.1 26.7 43.6 44.0 38.0 32.6 42.2 34.3 36.2 47.4 47.5 30.8 50.8 45.1 26.4 44.4 32.5 50.6 36.3 38.9 44.6 55.7 56.4 35.2 49.7 28.9 59.0 33.7 28.1 39.1 52.5 51.1 42.0 68.2 45.7 62.3 33.9 26.8 28.4 38.2 26.5 63.3 40.6 56.2 37.1 38.9 25.4 46.5 51.2 20.8 45.9 34.2 36.3 33.9 30.4 27.6 28.0 38.7 43.7 50.4 29.7 27.0 29.3 42.7 33.6 58.8 33.4 32.0 29.6 28.2 28.8 34.2 34.1 30.4 36.5 29.8 34.8 35.8 34.6 20.9 31.0 36.4 38.7 41.0 41.7 48.8 37.9 38.9 40.0 39.5 41.2 40.0 39.9 43.8 17.6 12.8 17.5 10.7 26.0 21.2 44.2 60.2 17.6 44.9 17.3 15.0 1.0 25.8 33.8 29.5 31.3 51.3 25.6 27.1 35.2 42.2 11.1 20.2 14.2 18.7 30.4 12.4 7.5 51.5 42.6 21.1 20.4 19.8 33.7 27.0 18.2 10.9 36.3 38.7 8.7 25.1 42.7 17.6 15.2 11.1 28.0 20.4 42.7 3.7 38.8 40.3 33.0 7.1 13.8 39.4 30.6 38.7 10.4 24.2 23.3 32.6 30.0 44.8 46.0 27.6 27.0 61.1 27.8 14.6 21.3 102.5 21.6 29.2 26.2 31.0 KAT6A "MOZ, MYST3, RUNXBP2, ZC2HC6A, ZNF220" ENSG00000083168 "Lysine acetyltransferase 6A" Q92794 8 41929479-42051994 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, Acyltransferase, Chromatin regulator, Repressor, Transferase" "Cancer-related genes, Mental retardation, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017023, HPA063266, HPA065052" Supported Supported "Nucleoli,Nuclear speckles,Cytosol" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 34: Non-specific - Transcription" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 24: Non-specific - Transcription regulation" "Nuclear speckles" "Nucleoli, Cytosol" "CAB017023: , HPA063266: AB_2684973, HPA065052: AB_2685414" "unprognostic (3.51e-2)" "unprognostic (1.14e-1)" "unprognostic (2.04e-1)" "unprognostic (3.23e-2)" "unprognostic (2.28e-1)" "unprognostic (9.27e-3)" "unprognostic (3.61e-1)" "unprognostic (2.29e-1)" "unprognostic (2.95e-1)" "unprognostic (2.45e-2)" "unprognostic (1.50e-1)" "unprognostic (4.45e-2)" "unprognostic (4.20e-3)" "unprognostic (1.18e-1)" "unprognostic (2.24e-1)" "unprognostic (8.58e-2)" "unprognostic (2.95e-2)" 14.4 7.1 8.6 15.4 12.7 38.2 12.3 20.1 10.5 13.7 9.7 10.2 9.6 15.6 8.6 13.4 12.0 11.2 9.1 9.1 12.8 9.1 10.0 16.7 16.8 12.7 12.4 21.5 11.7 18.0 6.7 14.9 12.9 11.0 10.6 18.1 9.6 9.7 13.1 16.6 12.1 13.5 8.2 15.7 11.3 11.4 10.1 27.0 14.2 16.0 17.2 12.0 10.7 16.7 19.6 23.2 34.8 21.8 17.8 20.3 9.8 15.4 20.6 17.9 14.2 16.3 11.5 33.4 13.4 19.0 19.5 17.3 27.3 18.6 23.2 16.1 14.4 60.4 14.2 10.3 14.8 27.3 23.6 17.1 19.1 20.4 24.8 14.5 18.8 29.7 36.6 24.2 16.0 10.4 59.9 9.4 12.8 20.4 8.1 37.7 39.1 9.9 11.0 27.1 17.6 16.7 15.8 12.4 13.8 15.8 26.3 12.9 25.5 21.6 15.3 21.1 15.5 16.8 22.1 33.8 12.6 14.1 17.3 2.5 0.8 1.8 1.6 0.9 1.6 1.4 1.6 2.1 0.6 1.6 1.9 1.8 5.1 1.9 0.9 1.1 1.9 1.2 8.6 12.7 20.1 10.5 9.1 12.8 12.7 12.4 12.9 8.2 10.1 16.7 87.5 35.3 34.9 64.0 54.0 50.3 24.2 15.5 18.2 54.8 31.7 25.5 23.7 18.6 25.3 12.9 54.2 14.4 61.5 23.2 3.9 14.2 2.6 30.3 47.5 56.7 24.7 31.2 62.8 11.8 17.0 32.4 21.4 44.8 35.4 31.9 43.5 25.3 17.0 58.9 76.6 24.9 10.2 44.2 34.5 4.8 28.3 43.7 23.2 120.9 30.3 27.9 61.8 93.5 129.2 15.7 20.2 23.0 38.7 30.7 22.9 10.6 22.8 44.9 19.7 49.3 34.6 37.8 37.0 23.0 61.2 21.1 61.4 19.7 19.3 27.2 KAT6B "Morf, MOZ2, MYST4, qkf, querkopf, ZC2HC6B" ENSG00000156650 "Lysine acetyltransferase 6B" Q8WYB5 10 74824927-75032624 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, Acyltransferase, Chromatin regulator, Repressor, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "PC-3: 25.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006104 Supported Approved "Nucleoplasm,Nuclear bodies" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 59: Non-specific - Translation" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 24: Non-specific - Transcription regulation" "Nucleoplasm, Nuclear bodies" "HPA006104: AB_1079445" "unprognostic (4.17e-1)" "unprognostic (1.98e-1)" "unprognostic (1.82e-1)" "unprognostic (2.32e-2)" "unprognostic (7.83e-2)" "unprognostic (2.85e-2)" "unprognostic (3.56e-1)" "unprognostic (2.62e-1)" "unprognostic (2.54e-1)" "unprognostic (1.09e-1)" "unprognostic (9.47e-2)" "unprognostic (8.78e-2)" "prognostic favorable (4.82e-4)" "unprognostic (2.52e-1)" "unprognostic (3.70e-1)" "unprognostic (2.59e-2)" "unprognostic (3.15e-1)" 7.6 6.3 5.0 3.1 5.6 8.8 7.3 5.6 5.3 10.5 2.0 9.6 3.2 9.2 5.2 6.9 8.3 3.8 7.5 5.7 4.0 4.3 4.6 6.5 4.4 3.1 3.5 12.2 8.6 10.5 7.4 4.4 3.0 6.5 4.1 6.4 7.3 4.3 11.8 8.0 8.1 6.0 3.0 5.4 9.3 7.8 5.6 9.8 7.3 6.0 4.1 9.1 8.9 4.9 4.7 4.4 8.0 6.9 6.2 9.2 4.1 4.1 7.5 3.4 3.6 3.4 5.3 9.8 2.1 7.1 3.5 3.8 4.2 3.3 5.6 4.2 6.8 3.6 3.9 4.5 4.5 8.6 2.4 5.9 5.3 4.5 6.9 10.5 3.8 7.7 3.9 9.0 4.2 4.7 8.2 4.3 5.0 4.9 25.7 12.7 4.3 2.4 2.3 2.3 4.2 6.9 4.1 7.4 3.7 2.8 4.5 3.2 4.7 4.6 5.5 3.1 3.8 6.4 8.1 6.4 5.0 8.9 1.3 1.7 1.3 1.6 2.3 1.0 2.6 2.2 1.9 2.1 1.1 2.8 2.9 2.6 1.8 4.4 1.1 1.7 1.7 1.0 5.0 5.6 5.6 5.3 5.7 4.0 3.1 3.5 3.0 3.0 5.6 4.9 34.5 44.8 53.7 90.1 48.1 19.9 20.8 16.3 74.6 52.8 36.7 27.3 53.9 12.8 29.3 9.2 68.8 10.4 51.8 22.5 9.8 12.7 6.2 41.1 72.7 24.9 23.8 32.0 130.2 18.0 10.6 44.4 57.6 50.8 41.7 68.0 18.9 16.0 11.0 43.7 131.2 21.7 12.2 12.3 15.0 8.3 42.3 24.1 14.2 41.2 13.6 45.5 42.2 101.0 92.1 10.5 19.4 40.3 62.5 21.0 17.8 10.2 28.6 52.5 26.3 55.3 44.1 33.1 32.2 46.6 17.5 22.7 59.7 27.1 17.5 23.5 KAT7 "HBO1, HBOA, MYST2, ZC2HC7" ENSG00000136504 "Lysine acetyltransferase 7" O95251 17 49788648-49835026 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Transcription factors" "DNA damage, DNA repair, DNA replication, Transcription, Transcription regulation" "Acyltransferase, Chromatin regulator, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA044470, HPA071116" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 42: Non-specific - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 5: NTERA-2 - Transcription" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm Cytosol "HPA044470: AB_10965785, HPA071116: " "unprognostic (1.30e-1)" "unprognostic (3.15e-2)" "unprognostic (6.20e-3)" "unprognostic (2.20e-2)" "unprognostic (7.99e-2)" "unprognostic (1.53e-1)" "unprognostic (1.35e-2)" "unprognostic (1.72e-2)" "unprognostic (1.36e-1)" "unprognostic (6.26e-2)" "unprognostic (1.44e-2)" "unprognostic (2.52e-1)" "unprognostic (1.33e-3)" "unprognostic (2.75e-1)" "unprognostic (5.03e-2)" "unprognostic (6.23e-2)" "unprognostic (7.68e-2)" 17.6 14.2 16.1 8.1 16.9 40.9 16.6 24.2 21.5 20.1 15.1 20.9 7.2 22.6 12.2 20.4 20.3 6.6 22.8 16.5 14.8 17.7 11.7 14.5 10.4 13.6 12.3 20.9 12.4 23.5 17.1 10.0 15.5 17.5 10.0 19.2 17.8 14.0 37.7 25.5 16.0 12.4 10.3 15.9 16.0 38.6 14.9 17.4 21.1 20.1 13.5 22.5 19.0 18.7 17.1 22.6 22.5 17.3 10.1 14.3 27.2 11.2 16.5 24.7 18.7 35.9 11.5 17.8 21.8 13.7 24.7 16.7 23.0 12.8 32.5 18.6 20.3 20.7 14.8 17.8 15.0 21.6 17.2 13.3 16.6 21.1 25.3 14.4 22.7 16.0 23.6 18.9 27.4 28.8 26.4 23.2 79.0 38.4 20.2 20.6 34.7 18.2 12.8 17.6 25.7 15.7 7.6 9.2 14.9 40.5 38.6 22.9 8.8 24.5 13.3 16.0 19.4 21.4 32.7 23.3 17.3 13.6 23.3 17.1 6.8 9.5 8.3 5.4 10.6 5.8 7.8 8.5 7.0 6.1 9.3 8.5 10.1 11.7 7.1 4.3 8.5 7.9 16.1 16.9 24.2 21.5 16.5 14.8 13.6 12.3 15.5 10.3 14.9 18.7 16.0 25.6 21.3 9.4 23.6 16.8 11.7 10.1 25.0 32.6 18.5 16.6 28.5 20.0 15.6 27.6 31.3 22.7 27.6 11.7 9.8 11.9 23.1 22.4 21.0 18.7 25.1 25.4 14.8 7.5 14.5 15.3 15.3 29.9 24.1 18.2 15.4 10.4 13.3 45.4 16.7 13.4 12.2 22.6 13.2 16.5 16.8 15.9 14.2 10.3 19.1 16.5 25.7 13.0 18.3 10.0 8.9 18.4 18.6 15.4 12.8 10.2 18.6 25.1 39.5 21.2 24.2 73.7 31.6 17.9 20.0 33.8 28.4 15.2 12.1 10.2 KAT8 "FLJ14040, hMOF, MOF, MYST1, ZC2HC8" ENSG00000103510 "Lysine acetyltransferase 8" Q9H7Z6 16 31114489-31131393 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, Acyltransferase, Chromatin regulator, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 113.9;Late spermatids: 147.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "eosinophil: 29.9" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA066324 Supported Nucleoplasm NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 80: Striated muscle - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 34: Spermatids - Unknown function" Nucleoplasm "HPA066324: AB_2685658" "unprognostic (8.58e-2)" "unprognostic (9.53e-2)" "unprognostic (7.83e-2)" "unprognostic (1.12e-2)" "unprognostic (8.59e-2)" "unprognostic (1.06e-1)" "unprognostic (3.22e-1)" "prognostic favorable (6.34e-4)" "unprognostic (3.13e-2)" "unprognostic (3.05e-1)" "unprognostic (5.50e-2)" "unprognostic (9.77e-2)" "unprognostic (7.33e-2)" "unprognostic (2.97e-1)" "unprognostic (1.29e-1)" "unprognostic (5.00e-1)" "unprognostic (1.41e-1)" 28.8 30.9 40.4 17.8 41.6 32.9 31.3 50.6 50.4 40.8 38.2 36.9 16.6 39.2 46.5 21.1 41.7 14.7 42.0 41.5 41.6 28.4 29.0 31.3 24.6 42.0 41.3 60.7 31.8 37.4 31.0 20.4 41.3 32.0 17.3 27.5 34.7 23.7 49.8 33.8 30.2 25.5 40.0 39.7 28.2 32.8 41.6 39.6 35.5 49.8 23.3 30.9 31.0 43.1 18.1 27.4 33.5 10.7 38.5 28.9 34.3 16.0 29.6 24.7 26.8 13.6 38.1 42.3 24.5 19.6 22.8 22.5 53.6 26.4 24.1 35.8 35.0 18.7 21.5 43.3 34.5 30.5 31.9 27.9 51.4 18.5 52.4 33.2 23.6 44.1 49.5 33.7 13.1 51.4 47.4 57.2 38.0 43.1 15.9 75.1 28.1 49.5 20.1 10.7 35.2 35.9 9.4 25.9 14.1 20.7 28.6 49.6 14.7 11.0 22.2 12.1 11.6 32.4 34.8 24.2 16.0 40.7 16.3 8.0 7.4 29.9 3.0 4.1 3.7 3.6 3.6 4.1 6.6 2.9 4.6 3.3 28.4 3.2 8.3 2.7 2.4 3.4 40.4 41.6 50.6 50.4 41.5 41.6 42.0 41.3 41.3 40.0 41.6 43.1 26.2 19.2 18.2 16.0 30.4 20.8 41.9 18.1 34.7 19.0 21.5 26.2 16.8 21.5 21.0 9.2 14.6 30.5 20.9 17.8 21.5 21.9 113.9 17.5 18.2 21.8 24.6 29.5 16.4 26.6 21.7 29.4 17.9 18.0 27.3 33.9 23.2 12.4 29.1 32.0 18.6 21.2 18.3 30.1 25.4 147.5 53.7 28.1 24.9 12.2 32.6 41.0 15.5 11.1 13.2 15.0 25.8 54.2 16.5 35.2 25.1 17.5 11.8 26.9 26.3 32.8 30.6 27.5 26.2 20.6 15.6 45.4 24.6 24.5 22.9 23.2 KCMF1 "DEBT91, DKFZP434L1021, PCMF, ZZZ1" ENSG00000176407 "Potassium channel modulatory factor 1" Q9P0J7 2 84971093-85059472 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030383, HPA030384" Enhanced Enhanced Nucleoplasm,Cytosol NA NA "Cluster 35: T-regs - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 30: Epithelial cell lines - Translation" "Cluster 22: Epithelial cell types - Mixed function" Cytosol Nucleoplasm "HPA030383: AB_10599977, HPA030384: AB_10601230" "unprognostic (8.01e-2)" "unprognostic (1.98e-2)" "unprognostic (9.95e-2)" "unprognostic (7.42e-3)" "unprognostic (1.24e-2)" "unprognostic (8.54e-2)" "prognostic unfavorable (2.33e-7)" "unprognostic (5.68e-3)" "unprognostic (1.43e-1)" "unprognostic (9.81e-2)" "prognostic unfavorable (6.10e-5)" "unprognostic (4.98e-2)" "prognostic unfavorable (4.18e-6)" "unprognostic (6.11e-2)" "unprognostic (2.66e-1)" "unprognostic (4.42e-1)" "unprognostic (1.01e-1)" 39.7 24.0 23.4 34.0 22.2 60.8 33.8 21.3 30.2 28.1 20.4 46.7 34.8 29.2 39.7 58.3 27.6 29.5 44.1 25.6 24.1 33.1 45.0 31.9 36.1 25.2 26.5 24.7 80.0 39.2 20.8 33.0 24.8 27.9 46.4 32.4 36.8 31.8 140.0 35.2 36.2 40.5 24.8 28.3 33.5 69.0 27.3 37.0 40.4 71.7 52.3 37.7 36.1 22.1 102.3 76.4 66.7 51.8 69.0 66.2 114.5 106.0 96.0 97.4 64.6 93.8 104.5 110.9 107.2 141.6 97.0 65.1 52.7 100.6 127.8 87.6 37.9 69.8 55.9 97.3 134.7 77.9 63.9 69.0 155.7 95.7 262.5 86.4 74.7 57.2 71.3 83.1 98.4 91.5 76.9 42.6 74.9 125.5 64.1 55.4 94.7 68.5 88.3 85.8 64.8 48.9 61.0 76.0 101.8 76.4 35.3 48.1 66.2 98.9 99.2 93.5 111.8 99.1 130.9 110.4 74.5 55.7 75.8 3.1 1.6 5.4 2.7 1.4 2.1 2.3 1.9 2.0 1.4 3.1 1.6 1.8 4.5 1.9 2.2 2.6 6.0 1.0 23.4 22.2 21.3 30.2 25.6 24.1 25.2 26.5 24.8 24.8 27.3 22.1 45.5 32.1 26.6 25.5 29.6 70.9 92.9 32.7 24.5 31.8 42.8 34.3 51.4 21.5 33.2 12.9 14.6 23.6 42.0 56.2 25.4 34.8 85.2 55.3 33.8 33.1 19.2 29.0 47.9 53.4 32.0 31.9 18.8 80.5 17.7 30.9 24.3 32.9 20.1 72.3 47.4 29.0 20.3 33.3 61.1 127.7 25.7 34.7 26.6 51.5 36.8 37.5 21.6 45.8 36.6 61.2 40.8 29.0 27.6 107.6 44.8 30.7 22.5 27.5 26.3 48.2 47.2 44.9 24.6 34.4 79.0 40.8 32.1 27.1 33.7 135.5 KDR "CD309, FLK1, VEGFR, VEGFR2" ENSG00000128052 "Kinase insert domain receptor" P35968 4 55078481-55125595 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, RAS pathway related proteins" "Angiogenesis, Differentiation, Host-virus interaction" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in many" 9 "Adipocytes: 157.8;Endothelial cells: 143.8;Hepatic stellate cells: 158.1;Muller glia cells: 206.6" "Cancer enhanced" "Detected in all" "renal cancer: 27.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 9 "HUVEC TERT2: 74.8;TIME: 83.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004028, HPA073577" Enhanced Approved "Nuclear membrane,Vesicles" "Intracellular and membrane" NA NA 11000000 "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 5: Muller glia cells - Visual perception" Vesicles "Nuclear membrane" "CAB004028: AB_2212507, HPA073577: " "unprognostic (1.61e-1)" "unprognostic (2.03e-1)" "unprognostic (9.65e-2)" "unprognostic (1.97e-1)" "unprognostic (9.63e-2)" "unprognostic (1.22e-2)" "unprognostic (1.78e-3)" "unprognostic (2.59e-2)" "unprognostic (1.19e-2)" "unprognostic (1.10e-1)" "unprognostic (8.79e-3)" "unprognostic (1.34e-1)" "prognostic unfavorable (7.26e-4)" "unprognostic (4.00e-2)" "unprognostic (2.30e-1)" "unprognostic (3.22e-1)" "unprognostic (1.86e-1)" 41.6 11.7 2.7 4.3 3.8 0.0 26.1 2.8 4.1 14.8 10.4 6.3 2.2 39.5 2.9 4.0 17.9 5.6 20.6 2.1 2.8 15.7 9.2 23.5 2.8 3.2 3.6 5.2 6.2 8.6 11.0 30.9 3.5 11.7 1.0 16.4 5.3 10.0 6.5 5.9 7.5 7.5 3.3 4.4 8.4 1.8 4.5 1.0 34.4 4.6 1.0 8.6 7.5 3.4 0.0 0.0 4.4 0.0 0.4 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.6 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 6.6 0.0 0.0 8.5 0.0 0.0 0.9 0.0 0.0 0.4 0.2 74.8 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.9 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 83.4 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 3.8 2.8 4.1 2.1 2.8 3.2 3.6 3.5 3.3 4.5 3.4 157.8 0.0 4.9 0.0 1.4 2.5 0.5 0.1 1.8 11.7 1.3 2.5 9.4 1.5 18.4 0.0 0.0 0.1 0.8 0.0 0.0 0.5 0.8 0.4 2.6 143.8 0.0 2.7 0.1 0.0 0.1 8.3 0.0 0.8 2.5 0.0 158.1 3.3 0.4 0.0 1.3 0.0 0.0 10.6 2.1 0.9 0.0 1.2 7.2 7.5 0.0 206.6 0.0 0.0 6.1 0.5 0.0 0.4 1.3 0.5 0.0 0.0 3.9 7.9 0.0 0.9 7.5 0.3 0.9 0.8 2.7 0.1 0.6 1.6 0.0 1.4 KHK ENSG00000138030 Ketohexokinase P50053 2 27086747-27100762 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Carbohydrate metabolism" "Kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 14 "intestine: 121.2;kidney: 104.4;liver: 180.5" "Cell type enhanced" "Detected in many" "Hepatocytes: 428.5;Proximal enterocytes: 1858.7;Proximal tubular cells: 1019.7" "Group enriched" "Detected in all" 7 "liver cancer: 62.2;renal cancer: 32.5" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HEL: 32.8;Hep G2: 48.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007040 Enhanced Approved Vesicles,Cytosol NA NA 620000 "Cluster 39: Non-specific - mRNA processing" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Cytosol Vesicles "HPA007040: AB_1079185" "unprognostic (8.44e-2)" "unprognostic (1.49e-1)" "unprognostic (1.70e-1)" "prognostic unfavorable (7.62e-8)" "unprognostic (2.25e-1)" "unprognostic (1.21e-1)" "unprognostic (3.08e-2)" "unprognostic (3.13e-2)" "unprognostic (1.67e-2)" "unprognostic (2.50e-2)" "unprognostic (3.01e-2)" "unprognostic (1.30e-1)" "unprognostic (1.68e-2)" "unprognostic (2.56e-3)" "unprognostic (2.32e-1)" "unprognostic (2.44e-1)" "unprognostic (1.02e-2)" 2.2 4.6 4.2 3.0 4.3 1.7 2.0 7.1 5.9 2.6 1.2 4.2 112.4 3.8 0.6 2.4 4.3 1.3 1.4 4.8 3.9 104.4 180.5 1.6 1.9 5.4 4.0 3.6 9.4 2.6 1.4 0.5 5.5 1.6 1.2 1.5 4.4 1.4 3.8 2.4 121.2 1.9 3.6 2.0 2.9 3.2 3.8 0.7 1.1 2.0 1.2 1.8 2.3 4.7 25.0 18.5 2.8 11.0 2.0 0.5 2.5 1.7 1.1 2.3 1.4 9.0 5.3 3.7 5.8 0.1 2.6 10.7 9.4 3.1 0.8 8.8 17.2 32.8 5.2 48.0 1.1 4.6 3.7 0.1 1.3 2.7 0.2 1.2 2.1 5.1 5.9 6.1 0.2 16.0 5.4 3.6 4.0 22.3 7.2 18.9 1.4 20.9 2.7 3.0 10.2 15.8 3.6 6.2 6.9 1.0 2.7 2.0 1.9 0.7 3.6 1.6 6.5 7.5 14.4 6.3 3.0 10.7 1.8 0.0 5.4 0.3 4.1 3.1 5.5 3.8 6.6 6.0 4.9 3.6 4.7 5.8 0.5 4.9 1.4 6.1 4.7 4.9 4.2 4.3 7.1 5.9 4.8 3.9 5.4 4.0 5.5 3.6 3.8 4.7 6.5 3.2 3.7 1.6 6.8 3.6 2.6 0.8 6.8 3.6 4.7 5.8 1.8 20.0 1.0 40.5 2.1 4.1 1.3 7.4 129.1 3.2 1.2 0.1 0.6 5.5 6.0 15.6 3.4 3.0 3.6 2.4 3.6 0.3 4.5 2.9 9.7 428.5 8.3 6.7 2.7 89.6 4.1 11.9 2.0 6.2 1.8 10.8 8.8 0.0 1.9 9.8 4.1 2.5 2.3 2.1 95.7 1.5 8.0 0.7 1858.7 1019.7 0.0 5.4 0.0 5.0 5.0 1.1 5.8 4.6 6.8 9.4 6.8 0.8 82.6 2.2 KIT "C-Kit, CD117, PBT, SCFR" ENSG00000157404 "KIT proto-oncogene, receptor tyrosine kinase" P10721 4 54657918-54740715 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, RAS pathway related proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "breast: 114.9" "Cell type enhanced" "Detected in many" "Breast glandular cells: 83.1;granulocytes: 529.3;Inhibitory neurons: 111.2;Ionocytes: 101.7;Melanocytes: 211.7" "Cancer enhanced" "Detected in many" "testis cancer: 28.6" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 7 "basophil: 20.3;eosinophil: 12.8;NK-cell: 13.1" "Group enriched" "Detected in many" 7 "granulocytes: 20.3;NK-cells: 13.1" "Group enriched" "Detected in many" 13 "HEL: 247.2;HMC-1: 496.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003288, HPA004471, CAB068253, CAB072867, HPA073252" Enhanced Supported Supported "Plasma membrane" NA NA 49000000 "Cluster 2: Granulocytes - Unknown function" "Cluster 5: Breast - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 60: Granulocytes - Receptor signaling" "Plasma membrane" "CAB003288: AB_2335702, CAB068253: AB_2665717, CAB072867: AB_2665718, HPA004471: AB_1078431, HPA073252: AB_2686589" "unprognostic (1.55e-2)" "unprognostic (1.91e-1)" "unprognostic (4.04e-2)" "unprognostic (8.19e-2)" "unprognostic (3.96e-2)" "unprognostic (2.18e-2)" "unprognostic (2.33e-2)" "unprognostic (1.97e-2)" "unprognostic (3.60e-2)" "unprognostic (1.64e-1)" "unprognostic (2.20e-1)" "unprognostic (1.92e-2)" "prognostic favorable (5.63e-4)" "unprognostic (1.34e-3)" "unprognostic (1.87e-1)" "unprognostic (1.29e-2)" "unprognostic (2.30e-1)" 6.6 1.8 8.2 5.3 6.3 6.4 114.9 21.4 6.5 17.6 5.1 13.5 9.2 9.6 5.9 13.0 2.9 20.3 3.4 23.9 5.1 12.4 0.8 21.8 3.4 6.8 12.3 45.0 2.6 1.7 1.9 10.0 8.8 5.6 16.0 3.2 21.4 8.7 1.1 24.5 13.4 10.1 5.9 5.0 17.4 6.2 16.7 3.1 47.1 6.9 6.2 14.5 4.9 5.1 0.0 0.0 3.9 0.0 0.7 0.3 0.0 3.3 4.6 12.6 15.8 0.0 0.0 0.0 0.0 7.3 0.6 0.3 2.6 0.0 10.8 0.0 5.9 247.2 0.0 0.0 0.0 0.0 496.2 0.0 0.0 0.0 0.0 0.0 28.4 4.3 3.5 0.5 0.0 0.0 1.4 2.5 6.9 0.0 0.0 0.8 0.0 0.0 0.0 24.2 6.0 2.1 0.0 0.0 0.0 14.1 0.0 2.6 0.3 0.5 0.0 4.9 0.1 0.4 0.0 0.0 0.5 0.9 0.6 20.3 0.0 12.8 0.1 0.0 2.3 0.0 0.4 0.9 2.3 0.0 0.0 0.0 1.0 13.1 1.4 0.1 0.0 0.2 8.2 6.3 21.4 6.5 23.9 5.1 6.8 12.3 8.8 5.9 16.7 5.1 7.3 6.4 21.9 9.8 1.0 14.3 0.9 0.4 2.2 4.5 83.1 59.2 0.7 4.3 3.6 3.7 0.0 0.1 5.2 0.4 3.9 1.0 0.0 0.2 0.7 9.2 5.4 15.5 0.9 0.0 0.1 2.8 8.6 0.7 529.3 0.5 1.8 0.0 0.3 0.0 111.2 0.5 101.7 0.3 4.2 0.4 1.2 1.6 211.7 14.0 0.2 2.4 0.0 16.1 3.7 0.0 0.1 0.0 3.2 0.5 0.0 0.8 0.1 0.2 0.0 0.7 0.8 0.1 12.3 2.2 3.8 0.3 8.8 63.7 0.6 0.3 KMT2A "ALL-1, CXXC7, HRX, HTRX1, MLL, MLL1A, TRX1" ENSG00000118058 "Lysine methyltransferase 2A" Q03164 11 118436490-118526832 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Apoptosis, Biological rhythms, Transcription, Transcription regulation" "Chromatin regulator, DNA-binding, Methyltransferase, Transferase" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017794, CAB024270, HPA044910" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 15: NK-cells - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 1: K-562 - Erythropoiesis" "Cluster 52: Non-specific - Transcription" Nucleoplasm Cytosol "CAB017794: , CAB024270: , HPA044910: AB_2679141" "unprognostic (6.80e-2)" "unprognostic (8.93e-2)" "unprognostic (1.83e-1)" "unprognostic (4.56e-1)" "unprognostic (4.96e-2)" "unprognostic (1.72e-3)" "unprognostic (4.52e-3)" "unprognostic (6.07e-2)" "unprognostic (1.61e-1)" "unprognostic (8.46e-2)" "unprognostic (3.21e-1)" "unprognostic (1.16e-1)" "unprognostic (5.91e-3)" "unprognostic (7.90e-2)" "unprognostic (3.73e-1)" "unprognostic (1.67e-1)" "unprognostic (1.02e-1)" 9.9 6.7 8.0 8.5 8.6 19.5 9.9 21.2 9.3 10.3 1.6 10.8 5.4 10.7 8.2 6.8 10.3 6.4 6.5 7.4 9.6 6.7 6.0 10.5 12.4 6.3 6.3 21.2 11.1 9.8 10.2 5.6 6.6 9.2 6.4 23.9 9.4 8.4 7.4 10.4 9.8 7.6 3.2 9.7 8.2 5.3 7.0 14.1 9.9 8.4 11.3 10.7 9.3 11.9 17.9 8.6 20.1 14.5 11.1 16.1 6.2 8.7 11.8 9.0 9.6 17.3 11.4 23.1 15.9 10.8 14.6 16.0 22.9 7.2 17.9 26.0 10.0 45.7 8.9 9.3 6.1 28.5 7.8 7.2 7.4 20.3 24.0 8.9 12.8 13.3 32.8 18.8 9.2 12.7 18.2 12.7 13.6 6.6 13.7 13.8 21.9 6.9 9.8 13.8 18.0 11.8 22.0 6.7 3.9 9.8 11.9 9.1 20.4 14.1 12.7 9.4 14.7 5.1 4.4 15.6 4.7 17.6 8.3 2.1 0.6 1.9 1.6 0.6 1.6 2.5 1.8 1.5 0.3 1.8 1.8 1.2 0.5 2.0 0.7 1.4 1.7 0.4 8.0 8.6 21.2 9.3 7.4 9.6 6.3 6.3 6.6 3.2 7.0 11.9 87.1 70.5 65.8 93.4 83.4 86.9 67.6 29.4 64.9 158.1 76.8 73.9 44.5 40.0 32.2 38.6 152.2 13.9 81.0 26.2 3.9 33.0 10.1 62.1 101.4 74.4 66.4 67.3 146.0 25.6 10.2 65.6 44.4 85.2 29.0 57.5 60.0 27.3 16.8 195.2 170.1 29.6 20.3 37.0 63.7 5.8 66.8 44.8 42.7 62.8 49.9 98.9 78.2 106.6 131.9 28.2 20.1 78.6 83.3 88.3 22.7 10.5 52.7 152.4 65.7 113.4 84.6 25.5 30.7 46.3 80.6 6.0 102.8 55.8 30.6 64.8 KMT2B "CXXC10, HRX2, KIAA0304, MLL1B, MLL2, MLL4, TRX2, WBP7" ENSG00000272333 "Lysine methyltransferase 2B" Q9UMN6 19 35717973-35738878 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Chromatin regulator, DNA-binding, Methyltransferase, Transferase" "Cancer-related genes, Disease variant, Dystonia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Bipolar cells: 64.5;Rod photoreceptor cells: 71.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006487 Approved Nucleoplasm,Cytosol NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 43: Testis - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 52: Non-specific - Transcription" Nucleoplasm Cytosol "HPA006487: AB_1080587" "unprognostic (1.09e-2)" "unprognostic (3.53e-2)" "unprognostic (3.41e-2)" "unprognostic (7.95e-2)" "unprognostic (9.92e-2)" "unprognostic (3.53e-3)" "unprognostic (2.33e-2)" "unprognostic (4.57e-2)" "unprognostic (7.28e-2)" "unprognostic (2.07e-2)" "unprognostic (3.13e-3)" "unprognostic (2.63e-3)" "unprognostic (9.47e-3)" "unprognostic (2.10e-1)" "unprognostic (2.37e-1)" "unprognostic (3.77e-2)" "unprognostic (2.24e-2)" 11.6 10.1 15.4 9.8 15.7 14.3 11.8 17.2 22.9 12.9 12.2 13.6 9.8 14.1 4.4 12.8 13.1 6.8 8.4 14.7 14.8 10.3 10.0 12.1 14.5 15.4 14.4 16.1 16.0 5.1 14.5 5.8 14.7 13.4 3.9 5.8 13.3 5.8 16.1 18.8 14.5 4.5 12.4 15.6 12.7 22.5 15.9 9.3 16.6 5.0 6.8 12.6 12.0 16.0 16.7 36.7 11.1 17.3 6.0 4.3 11.0 6.7 4.7 7.3 5.0 25.3 7.4 15.5 11.8 5.1 8.5 10.8 11.3 5.2 4.2 21.2 13.6 29.7 20.2 24.4 8.6 17.4 26.1 6.9 9.4 8.9 10.7 6.9 5.7 13.5 22.5 15.8 6.4 34.1 15.9 24.4 12.0 18.8 9.2 19.8 8.9 7.6 7.8 21.3 14.0 10.0 13.5 20.6 11.3 7.9 11.8 21.3 12.5 16.3 17.0 10.5 17.4 22.2 15.7 12.4 8.5 18.8 12.2 0.3 0.4 0.4 1.0 0.1 0.5 0.4 0.6 0.7 0.3 0.7 0.6 0.9 1.8 0.5 0.2 2.1 0.8 0.4 15.4 15.7 17.2 22.9 14.7 14.8 15.4 14.4 14.7 12.4 15.9 16.0 24.6 9.6 15.4 13.7 18.6 12.7 10.0 6.2 9.6 64.5 16.1 14.6 9.2 8.6 6.3 9.2 52.1 6.5 27.4 25.2 0.0 6.4 2.8 17.9 31.6 15.6 20.3 7.4 11.7 7.7 6.1 12.4 27.5 26.0 5.1 30.5 11.0 11.2 8.4 35.3 11.8 14.1 6.1 11.8 7.1 4.7 8.1 13.4 5.4 7.5 9.5 25.7 19.6 7.5 10.0 8.4 16.7 12.4 17.9 19.6 13.9 5.0 6.7 71.2 0.0 25.0 17.3 26.5 38.5 11.9 12.9 9.4 20.6 30.7 16.3 14.8 KMT2C "HALR, KIAA1506, MLL3" ENSG00000055609 "Lysine methyltransferase 2C" Q8NEZ4 7 152134922-152436641 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Transcription, Transcription regulation" "Activator, Acyltransferase, Chromatin regulator, DNA-binding, Methyltransferase, Transferase" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 363.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 15.2" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA074736 Approved Nucleoplasm NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 80: Striated muscle - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 44: Endometrium - Transcription" Nucleoplasm "HPA074736: AB_2686709" "unprognostic (7.75e-2)" "unprognostic (3.10e-1)" "unprognostic (2.83e-1)" "unprognostic (1.33e-2)" "unprognostic (1.31e-1)" "unprognostic (5.23e-3)" "unprognostic (1.09e-1)" "unprognostic (1.59e-2)" "unprognostic (1.01e-1)" "unprognostic (1.17e-1)" "unprognostic (3.45e-1)" "unprognostic (1.06e-1)" "prognostic favorable (8.01e-6)" "unprognostic (1.78e-1)" "unprognostic (3.83e-1)" "unprognostic (3.04e-2)" "unprognostic (2.64e-1)" 12.7 11.2 16.7 7.3 25.7 16.4 12.9 16.7 15.7 15.3 5.5 13.1 5.7 14.3 13.7 14.1 11.9 7.7 10.2 13.0 18.9 8.9 10.4 12.7 8.1 25.3 19.4 16.8 18.5 12.4 12.1 10.3 20.6 9.3 7.6 21.7 14.2 9.0 25.9 17.6 12.8 7.5 12.2 12.2 15.2 13.4 19.1 16.1 14.6 16.9 9.5 11.3 12.7 28.6 13.4 6.1 11.6 11.7 19.0 13.9 10.2 4.7 6.4 5.0 5.5 10.9 4.7 22.4 8.9 11.3 9.2 5.2 14.3 7.5 9.2 12.7 6.5 14.0 7.3 4.5 8.9 22.9 12.8 6.6 9.1 7.1 8.2 7.2 8.4 9.7 22.5 15.0 11.7 12.7 14.8 11.1 6.8 8.5 7.9 9.5 12.3 8.4 5.8 10.9 19.6 12.8 13.4 15.8 6.3 10.6 4.6 15.7 12.8 8.0 4.4 9.0 8.9 15.3 7.7 22.4 10.7 14.7 8.4 6.1 3.0 4.4 1.9 2.7 1.6 6.9 2.0 1.5 1.4 3.9 1.9 1.4 15.2 2.2 2.6 3.7 1.3 0.8 16.7 25.7 16.7 15.7 13.0 18.9 25.3 19.4 20.6 12.2 19.1 28.6 62.4 76.9 71.9 292.8 75.0 89.1 38.3 31.5 62.0 89.0 59.6 35.2 65.8 44.3 72.4 46.0 173.0 38.0 61.9 61.7 5.9 37.6 32.1 94.4 92.1 58.9 67.9 55.5 180.7 33.1 51.7 58.3 89.2 200.5 65.2 52.8 56.7 46.0 33.7 80.8 172.2 53.5 42.7 54.7 79.6 17.3 67.4 90.5 42.7 202.4 77.1 57.7 59.8 299.6 363.2 37.6 49.0 60.2 90.3 53.6 36.3 14.7 46.9 73.0 26.3 83.0 55.5 42.3 33.9 80.9 96.3 127.2 76.8 54.8 39.1 61.4 KMT2D "ALR, CAGL114, MLL2, MLL4, TNRC21" ENSG00000167548 "Lysine methyltransferase 2D" O14686 12 49018978-49060794 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Transcription, Transcription regulation" "Chromatin regulator, Methyltransferase, Transferase" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "neutrophil: 1.5" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA035977 Approved Approved "Nucleoplasm,Plasma membrane,Cytosol" Yes No "Cluster 33: Neutrophils - Chromatin organization" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 1: K-562 - Erythropoiesis" "Cluster 9: Photoreceptor cells - Phototransduction" Cytosol "Nucleoplasm, Plasma membrane" "HPA035977: AB_10670673" "unprognostic (8.33e-2)" "unprognostic (1.49e-1)" "unprognostic (9.14e-2)" "unprognostic (2.52e-1)" "unprognostic (8.07e-2)" "unprognostic (6.91e-3)" "unprognostic (7.35e-2)" "unprognostic (2.29e-1)" "unprognostic (3.57e-1)" "unprognostic (5.14e-2)" "unprognostic (7.23e-2)" "unprognostic (3.07e-1)" "unprognostic (1.68e-2)" "unprognostic (7.10e-2)" "unprognostic (1.87e-1)" "unprognostic (3.20e-2)" "unprognostic (7.60e-2)" 19.9 21.9 14.0 17.0 14.4 62.1 20.3 14.7 18.1 20.2 3.8 21.3 13.2 26.9 14.4 25.5 24.1 11.7 23.7 12.1 9.1 18.2 20.5 25.1 17.5 9.3 8.2 25.3 33.2 22.9 25.4 16.2 8.6 19.2 14.7 48.0 22.1 16.2 44.9 30.4 27.9 15.5 3.1 36.6 25.5 23.6 12.7 29.0 26.5 21.9 17.2 19.4 19.4 13.4 32.3 31.9 31.0 24.7 29.3 20.4 32.6 17.3 17.1 20.3 10.9 54.8 14.1 33.4 21.2 23.9 14.0 21.5 38.1 19.9 17.7 22.4 26.7 47.2 37.7 29.9 20.5 59.1 43.2 18.4 25.8 30.7 32.0 27.3 31.8 33.2 55.1 19.2 23.7 37.4 26.8 48.0 29.9 45.4 25.0 37.4 22.4 12.0 18.1 37.2 24.6 21.2 28.1 25.5 19.5 26.1 24.0 44.1 49.8 15.5 30.7 14.5 30.5 24.8 20.9 31.7 17.1 28.0 12.5 0.5 0.2 0.3 0.2 0.0 0.1 0.1 0.1 0.1 0.0 0.2 0.1 0.1 1.5 0.5 0.0 0.2 0.0 0.1 14.0 14.4 14.7 18.1 12.1 9.1 9.3 8.2 8.6 3.1 12.7 13.4 12.9 9.6 19.1 17.6 13.3 14.0 7.8 8.1 14.2 26.8 12.1 7.1 7.8 12.8 10.9 18.4 52.1 8.2 15.3 12.3 1.9 6.3 2.8 10.7 12.7 13.2 13.1 16.0 17.4 6.0 6.0 8.8 24.5 13.1 8.2 23.3 17.9 13.0 9.8 21.9 16.5 10.0 6.1 15.7 18.4 2.4 9.6 15.4 10.6 15.0 14.9 6.4 17.5 12.5 19.8 8.8 9.5 10.9 10.1 11.0 13.3 4.5 9.0 38.4 6.6 14.4 12.5 6.5 3.8 18.9 17.6 11.4 15.3 10.8 10.3 9.6 KMT5A "PR-Set7, SET07, SET8, SETD8" ENSG00000183955 "Lysine methyltransferase 5A" Q9NQR1 12 123383773-123409353 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, Transcription, Transcription regulation" "Chromatin regulator, Methyltransferase, Repressor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Erythroid cells: 62.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA064495 Supported Nucleoplasm,Cytosol NA Yes "Cluster 49: Eosinophils - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 1: K-562 - Erythropoiesis" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm Cytosol "HPA064495: AB_2685273" "unprognostic (5.62e-2)" "unprognostic (4.45e-2)" "unprognostic (3.90e-1)" "unprognostic (3.04e-1)" "unprognostic (2.20e-2)" "unprognostic (1.73e-1)" "prognostic unfavorable (6.21e-7)" "unprognostic (3.88e-3)" "unprognostic (1.06e-2)" "unprognostic (1.64e-2)" "unprognostic (6.13e-2)" "unprognostic (3.44e-1)" "unprognostic (4.75e-3)" "unprognostic (4.27e-2)" "unprognostic (1.30e-1)" "unprognostic (4.39e-2)" "unprognostic (1.06e-1)" 13.7 10.1 22.6 15.3 22.1 39.2 13.1 20.8 23.2 22.2 18.7 17.7 12.8 21.3 12.9 40.7 21.7 13.6 17.0 22.2 20.6 13.7 14.0 15.5 15.4 22.4 22.7 12.0 19.7 11.4 10.7 16.5 22.9 30.2 14.4 11.7 24.0 19.7 24.4 28.1 15.6 16.7 21.4 16.8 16.9 7.9 23.3 17.9 25.7 15.3 16.6 16.6 25.7 23.9 37.3 24.3 27.8 43.5 18.1 30.9 40.1 57.4 26.3 32.0 26.9 28.8 21.9 84.9 33.1 37.5 11.7 35.8 41.6 21.7 33.3 39.3 45.0 68.8 26.4 15.2 26.5 54.8 18.8 15.1 27.1 34.7 32.8 30.2 26.2 36.4 136.8 38.1 27.5 29.9 58.1 84.9 13.8 34.6 29.0 70.4 22.1 24.1 22.8 43.4 37.9 30.9 51.3 28.3 28.6 23.6 39.6 75.3 32.4 35.2 26.0 42.3 42.3 23.0 25.9 75.9 24.6 29.6 29.9 2.3 1.2 4.3 1.3 2.1 2.7 1.7 1.6 2.1 1.0 1.1 0.9 1.1 1.8 2.3 2.1 2.0 1.5 0.3 22.6 22.1 20.8 23.2 22.2 20.6 22.4 22.7 22.9 21.4 23.3 23.9 34.5 12.8 14.5 0.0 12.7 0.0 17.6 0.0 20.5 20.8 32.0 27.3 0.0 7.2 6.8 27.6 6.2 15.1 22.4 10.4 7.9 9.2 10.1 46.8 43.8 20.7 4.9 62.1 0.0 9.4 16.6 14.7 15.8 41.1 2.5 21.3 30.4 19.5 17.7 3.3 0.0 22.2 0.0 16.8 0.0 3.2 16.1 19.6 0.0 0.0 3.4 28.7 7.2 0.0 0.0 13.6 9.6 42.9 15.9 24.1 14.3 13.1 11.7 17.9 6.6 23.2 19.7 9.7 10.2 38.8 0.0 14.2 14.5 18.4 12.7 22.5 KMT5B "CGI-85, SUV420H1" ENSG00000110066 "Lysine methyltransferase 5B" Q4FZB7 11 68154863-68213828 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Myogenesis, Transcription, Transcription regulation" "Chromatin regulator, Methyltransferase, Repressor, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "SK-MEL-30: 128.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA063648 Supported Nucleoplasm NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 59: Non-specific - Transcription" Nucleoplasm "HPA063648: AB_2685073" "unprognostic (5.82e-2)" "unprognostic (4.25e-2)" "unprognostic (2.54e-1)" "unprognostic (5.36e-3)" "unprognostic (3.52e-1)" "unprognostic (2.94e-1)" "unprognostic (1.83e-2)" "unprognostic (1.08e-1)" "unprognostic (3.16e-2)" "unprognostic (1.71e-1)" "unprognostic (5.54e-2)" "unprognostic (1.21e-1)" "unprognostic (3.79e-3)" "unprognostic (2.62e-1)" "unprognostic (4.26e-2)" "unprognostic (3.21e-2)" "prognostic favorable (9.30e-4)" 18.6 16.5 16.3 15.7 17.5 28.5 27.5 26.2 17.6 20.2 17.3 22.3 22.8 26.2 19.0 17.2 18.2 15.0 15.9 15.8 17.2 19.7 22.4 18.1 19.2 16.1 16.3 22.4 22.8 20.6 15.6 22.3 15.6 22.0 21.6 33.4 23.4 16.3 16.9 21.7 21.8 20.7 14.8 17.2 20.7 20.7 16.1 27.0 31.0 16.7 20.4 16.5 17.6 21.3 25.3 18.8 37.6 24.5 8.6 21.4 40.8 17.7 12.3 21.7 12.8 59.7 39.6 20.5 30.2 24.4 21.4 13.0 26.2 20.6 31.6 23.2 15.1 19.4 21.9 24.7 31.0 27.7 25.6 21.3 41.6 26.2 27.3 20.0 21.8 20.3 29.3 23.4 18.7 52.2 19.6 28.9 40.4 50.4 13.9 31.9 29.4 55.4 16.2 24.2 32.7 39.1 27.5 27.4 128.7 20.3 35.1 17.9 23.1 29.2 38.9 22.5 18.4 29.5 13.8 43.0 18.4 17.3 31.8 10.0 3.7 16.5 4.4 5.2 3.1 3.2 4.6 5.4 3.5 3.8 5.3 4.8 10.9 9.6 5.3 5.4 4.1 2.8 16.3 17.5 26.2 17.6 15.8 17.2 16.1 16.3 15.6 14.8 16.1 21.3 39.8 60.9 61.3 0.0 32.9 0.0 42.3 0.0 50.7 50.0 45.8 34.7 0.0 25.8 25.4 25.8 12.5 27.4 37.6 32.6 21.5 27.9 22.0 42.6 46.3 31.7 25.5 31.4 0.0 32.7 29.6 26.3 37.2 44.3 22.7 40.7 30.0 37.7 17.9 63.9 0.0 26.6 0.0 32.4 0.0 21.0 28.0 27.7 0.0 0.0 38.2 29.6 43.3 0.0 0.0 37.1 25.7 31.6 34.8 43.7 36.4 22.7 32.1 39.6 32.9 44.8 28.6 45.8 58.9 38.0 0.0 51.7 30.7 31.8 25.1 53.6 KMT5C "MGC2705, SUV420H2" ENSG00000133247 "Lysine methyltransferase 5C" Q86Y97 19 55339853-55348121 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" "Chromatin regulator, Methyltransferase, Repressor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Bipolar cells: 47.9;Cone photoreceptor cells: 50.1;Horizontal cells: 67.3;Rod photoreceptor cells: 49.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HEK 293: 20.7;SCLC-21H: 19.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA052294 Uncertain Supported Nucleoplasm NA NA "Cluster 35: Non-specific - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 62: Horizontal cells - Visual perception" Nucleoplasm "HPA052294: AB_2681788" "unprognostic (4.02e-2)" "unprognostic (3.45e-2)" "unprognostic (2.92e-3)" "unprognostic (6.77e-3)" "unprognostic (2.48e-1)" "unprognostic (8.27e-2)" "unprognostic (2.29e-2)" "unprognostic (1.27e-1)" "unprognostic (8.69e-2)" "unprognostic (3.04e-1)" "unprognostic (9.48e-3)" "unprognostic (1.49e-2)" "prognostic unfavorable (1.05e-8)" "unprognostic (7.39e-2)" "unprognostic (2.96e-1)" "unprognostic (9.41e-2)" "unprognostic (2.39e-2)" 3.7 5.9 5.5 1.3 6.0 5.0 4.6 6.4 6.5 5.6 4.3 5.4 3.5 5.0 0.9 4.8 8.6 1.1 4.5 5.1 4.9 5.2 5.1 5.4 1.5 6.1 5.7 6.3 5.9 1.3 11.1 1.9 5.9 6.7 0.9 2.6 5.2 1.3 2.8 9.2 5.0 0.7 4.9 5.7 4.8 7.1 5.8 1.9 4.6 0.6 0.9 4.6 4.5 7.4 6.2 4.1 4.1 3.3 0.8 1.0 10.5 1.8 0.7 0.6 1.5 2.8 5.1 6.2 2.2 1.3 0.3 3.1 2.8 2.2 0.7 5.5 20.7 4.2 3.7 3.0 1.4 2.7 5.7 1.0 2.9 1.9 1.0 1.4 1.3 6.5 12.4 3.6 0.7 7.1 8.6 6.4 7.0 3.8 6.0 12.3 4.7 6.2 1.0 1.5 19.3 8.2 0.9 4.9 2.4 2.6 5.3 3.7 1.4 2.1 4.4 0.9 1.3 9.8 5.2 4.1 1.2 6.5 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 5.5 6.0 6.4 6.5 5.1 4.9 6.1 5.7 5.9 4.9 5.8 7.4 3.3 6.4 4.1 0.0 4.9 0.0 13.5 0.0 7.4 47.9 11.8 9.3 0.0 8.6 3.1 3.7 50.1 31.1 13.3 7.5 1.9 6.6 2.3 27.4 7.5 3.9 7.3 18.9 0.0 2.9 20.4 5.4 16.3 18.0 2.5 11.1 6.1 1.1 9.6 67.3 0.0 15.0 0.0 5.1 0.0 2.4 7.5 6.2 0.0 0.0 2.2 19.9 8.2 0.0 0.0 8.7 11.9 6.4 9.8 10.6 21.1 2.7 3.6 49.7 6.6 5.4 3.0 21.0 30.5 6.5 0.0 19.8 13.0 23.0 11.3 11.8 KSR1 "KSR, RSU2" ENSG00000141068 "Kinase suppressor of ras 1" Q8IVT5 17 27456470-27626438 "Enzymes, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "pancreas: 101.4" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 73.0;Glandular and luminal cells: 50.3;Inhibitory neurons: 50.2;Oligodendrocyte precursor cells: 53.3;Oligodendrocytes: 49.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "eosinophil: 3.8" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HDLM-2: 393.5;HEL: 140.5;HMC-1: 93.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009623, HPA011215, HPA011878" Uncertain Supported Vesicles,Cytosol NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 22: Non-specific - Unknown function" "Cluster 44: HDLM-2 - Immune response" "Cluster 44: Endometrium - Transcription" Cytosol Vesicles "CAB009623: AB_2265455, HPA011215: AB_1852649, HPA011878: " "unprognostic (2.03e-2)" "unprognostic (2.74e-1)" "unprognostic (2.60e-1)" "unprognostic (3.48e-3)" "unprognostic (2.90e-1)" "unprognostic (6.98e-2)" "unprognostic (1.92e-5)" "unprognostic (8.36e-3)" "unprognostic (1.32e-1)" "unprognostic (3.15e-2)" "unprognostic (1.12e-3)" "unprognostic (1.65e-1)" "prognostic unfavorable (6.54e-4)" "unprognostic (1.00e-1)" "unprognostic (7.55e-2)" "unprognostic (1.74e-2)" "unprognostic (9.61e-2)" 22.6 17.5 19.6 19.9 22.0 16.7 15.6 17.4 35.8 36.9 13.2 13.1 8.1 26.5 9.9 29.8 20.8 21.4 13.6 33.1 19.3 40.7 6.5 26.2 14.3 28.6 20.2 26.4 101.4 7.3 15.1 44.9 23.0 15.6 8.5 19.4 8.4 18.5 30.0 21.6 15.2 20.0 17.5 22.5 9.3 25.3 22.9 11.6 31.0 14.0 14.6 14.6 23.1 26.7 4.6 18.1 11.1 5.8 9.2 6.5 64.7 4.2 9.1 6.2 7.2 55.0 0.8 4.4 9.5 8.0 40.8 2.8 11.0 2.5 3.7 393.5 12.1 140.5 19.3 23.0 16.0 1.8 93.0 8.1 4.0 17.8 0.5 25.3 34.8 6.1 75.0 0.5 3.6 4.4 2.1 5.4 8.3 4.0 3.2 9.1 61.5 3.2 25.1 3.3 17.1 11.3 22.3 5.1 6.0 29.4 0.7 7.5 32.5 1.8 8.2 5.1 3.0 0.5 0.1 0.1 1.8 7.9 10.5 0.0 1.0 3.8 0.3 2.1 0.3 0.4 0.1 0.2 0.5 0.1 0.1 0.1 1.1 0.9 1.1 0.0 0.5 0.4 19.6 22.0 17.4 35.8 33.1 19.3 28.6 20.2 23.0 17.5 22.9 26.7 19.7 6.4 3.4 33.6 4.1 3.1 3.6 3.1 1.8 11.8 1.9 2.3 1.2 1.5 11.9 14.7 73.0 19.2 4.9 7.1 3.9 2.0 33.4 24.0 21.6 9.1 6.6 0.4 26.2 5.3 21.0 8.2 3.6 50.3 0.0 10.8 11.7 1.3 6.7 10.1 50.2 2.2 0.0 8.3 6.9 47.7 1.5 9.0 8.8 27.2 10.4 5.7 4.1 53.3 49.2 2.1 7.1 2.2 2.8 1.6 6.7 3.2 14.9 25.8 0.0 5.3 4.8 2.6 6.1 11.3 6.0 19.4 5.7 8.4 1.2 6.2 KSR2 FLJ25965 ENSG00000171435 "Kinase suppressor of ras 2" Q6VAB6 12 117453012-117968990 "Enzymes, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "brain: 10.0;pituitary gland: 7.9" "Cell type enhanced" "Detected in many" "Collecting duct cells: 161.8;Excitatory neurons: 284.7;Inhibitory neurons: 234.9;Oligodendrocyte precursor cells: 95.0" "Not detected" "Not detected" "Region enhanced" "Detected in many" "cerebral cortex: 10.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HUVEC TERT2: 4.5;SCLC-21H: 3.2;TIME: 6.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA035536 Enhanced NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA035536: AB_10673485" "unprognostic (1.74e-2)" "unprognostic (4.21e-2)" "unprognostic (2.38e-1)" "unprognostic (2.29e-2)" "unprognostic (9.11e-2)" "unprognostic (8.42e-2)" "unprognostic (6.91e-3)" "unprognostic (1.10e-2)" "unprognostic (5.78e-2)" "unprognostic (5.80e-2)" "unprognostic (2.05e-4)" "unprognostic (1.19e-1)" "unprognostic (9.28e-3)" "unprognostic (5.02e-2)" "unprognostic (5.68e-2)" "unprognostic (8.14e-3)" "unprognostic (5.74e-2)" 0.0 0.9 2.3 0.0 2.4 0.0 0.2 1.1 10.0 0.0 0.0 0.2 0.0 0.0 0.4 0.0 0.2 0.0 0.0 7.7 0.0 0.7 0.0 0.0 0.1 0.7 0.0 0.0 0.5 0.6 7.9 0.0 0.6 0.1 0.3 1.9 0.1 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.8 0.3 0.0 0.6 0.0 0.1 0.2 0.0 2.7 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.0 0.1 0.1 0.0 0.0 0.0 0.3 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.5 1.3 0.0 0.0 0.0 1.0 0.0 0.0 0.3 0.0 0.8 0.0 0.0 0.1 0.4 0.9 3.2 0.1 0.0 0.0 0.0 0.0 0.7 0.0 6.9 0.0 0.5 0.0 0.1 0.5 1.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 2.4 1.1 10.0 7.7 0.0 0.7 0.0 0.6 0.1 0.3 2.7 0.9 0.0 0.0 17.6 0.5 0.3 1.2 0.1 0.0 55.2 2.8 2.4 2.2 5.7 0.2 161.8 39.6 0.9 0.0 1.3 0.0 2.3 10.8 4.0 0.3 0.5 20.4 5.3 284.7 1.5 0.4 0.1 0.0 4.7 0.0 0.0 0.0 0.0 0.1 47.1 234.9 10.3 2.0 0.3 0.4 12.5 0.0 0.0 0.0 5.6 0.0 2.4 0.0 95.0 4.2 0.4 1.5 0.0 0.0 1.4 0.1 0.8 0.3 28.2 0.0 0.3 0.1 0.6 3.1 0.0 0.3 0.3 0.6 0.0 3.0 1.3 KYAT1 "CCBL1, GTK, KATI" ENSG00000171097 "Kynurenine aminotransferase 1" Q16773 9 128832942-128882494 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Aminotransferase, Lyase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in some" 6 "Granulosa cells: 45.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "HPA021176, HPA021177, HPA027736" Approved Supported Cytosol NA NA 22000 "Cluster 27: Non-specific - Gene expression" "Cluster 39: Non-specific - Mitochondria" "Cluster 20: HeLa - Mitochondria" "Cluster 40: Granulosa cells - Unknown function" Cytosol "HPA021176: AB_1846120, HPA021177: AB_1846119, HPA027736: AB_10611818" "unprognostic (6.51e-2)" "unprognostic (8.67e-3)" "unprognostic (1.05e-2)" "unprognostic (5.98e-3)" "unprognostic (2.15e-2)" "unprognostic (5.44e-2)" "unprognostic (2.91e-2)" "unprognostic (1.12e-2)" "unprognostic (2.47e-1)" "unprognostic (8.60e-3)" "unprognostic (1.43e-1)" "unprognostic (3.65e-2)" "unprognostic (3.10e-2)" "unprognostic (5.79e-2)" "unprognostic (2.03e-1)" "unprognostic (1.08e-1)" "unprognostic (1.98e-1)" 3.5 4.7 12.3 3.6 13.3 2.3 4.0 13.0 15.5 7.2 10.6 4.7 2.5 5.8 2.9 5.3 6.4 2.7 10.3 12.1 11.8 7.8 12.7 3.6 5.0 13.2 12.3 6.2 3.1 5.5 8.7 2.5 12.8 7.4 1.3 7.5 4.2 4.3 12.6 7.7 4.2 3.1 12.3 5.4 4.9 5.6 12.9 8.9 6.1 8.7 4.8 7.2 6.7 18.0 4.8 9.8 9.3 10.6 6.9 11.4 3.0 5.5 8.0 6.2 8.0 3.9 9.7 8.3 2.9 4.6 7.0 14.9 13.9 11.1 9.3 10.0 7.3 5.7 27.7 9.6 7.7 5.0 1.9 4.5 7.1 7.1 7.7 21.8 11.3 22.7 8.2 9.0 8.5 3.1 14.0 3.4 15.2 18.3 7.6 16.4 6.4 18.9 8.7 1.7 10.5 7.4 9.9 2.9 6.2 12.8 6.6 1.6 7.0 4.6 7.9 7.1 5.0 15.2 11.0 11.6 9.6 8.3 3.2 0.1 1.4 2.9 5.1 1.8 4.5 7.7 5.7 6.0 5.5 3.3 5.9 6.7 0.9 3.3 2.9 2.4 7.0 3.3 12.3 13.3 13.0 15.5 12.1 11.8 13.2 12.3 12.8 12.3 12.9 18.0 2.6 0.0 1.5 0.0 1.5 0.0 0.0 0.0 0.0 0.0 2.0 1.5 0.0 0.0 0.6 0.0 0.0 5.0 0.9 0.0 3.9 1.6 0.0 2.6 3.3 0.7 0.0 0.0 0.0 0.2 2.4 0.7 0.0 4.2 0.0 45.1 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.3 0.0 0.0 7.3 2.9 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 2.1 1.3 1.3 0.0 0.0 KYAT3 "CCBL2, KAT3, KATIII, RBM1, RP11-82K18.3" ENSG00000137944 "Kynurenine aminotransferase 3" Q6YP21 1 88935773-88992953 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Aminotransferase, Lyase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 70.7;Exocrine glandular cells: 38.2;Extravillous trophoblasts: 39.9;Proximal tubular cells: 35.6;Syncytiotrophoblasts: 83.5;Theca cells: 43.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026538, HPA027168" Enhanced Approved "Nucleoli,Cytokinetic bridge,Cytosol" Yes NA "Cluster 27: Non-specific - Gene expression" "Cluster 1: Thyroid gland - Transcription" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 7: Non-specific - Mitochondria" Cytosol "Nucleoli, Cytokinetic bridge" "HPA026538: AB_1852076, HPA027168: AB_1852078" "prognostic favorable (3.19e-5)" "unprognostic (3.36e-3)" "unprognostic (1.88e-2)" "unprognostic (1.62e-1)" "unprognostic (2.01e-2)" "prognostic favorable (1.86e-4)" "unprognostic (2.61e-1)" "unprognostic (3.61e-3)" "unprognostic (2.11e-1)" "prognostic favorable (2.80e-4)" "unprognostic (1.04e-1)" "unprognostic (3.17e-1)" "prognostic favorable (5.02e-6)" "unprognostic (1.17e-1)" "unprognostic (1.06e-1)" "unprognostic (2.51e-1)" "unprognostic (2.78e-1)" 19.3 22.5 8.3 16.0 9.3 13.4 29.8 10.0 12.2 18.0 12.3 19.9 22.6 21.3 21.7 26.5 18.3 20.0 11.3 9.4 9.5 30.5 27.4 15.4 22.1 8.5 9.5 25.7 30.0 33.4 15.2 22.7 9.2 21.1 21.7 11.0 20.5 22.1 10.6 18.8 17.4 15.7 8.7 17.6 22.7 9.9 8.7 21.6 26.2 10.0 23.7 24.6 14.9 8.9 55.1 11.1 52.2 18.0 19.1 51.2 46.4 31.7 57.2 39.8 49.4 15.6 18.9 35.6 23.8 23.8 27.3 15.7 15.6 25.6 57.7 22.7 21.3 32.4 9.8 26.8 61.8 45.6 8.5 44.9 25.2 29.0 50.1 26.8 37.0 41.0 41.5 19.0 37.9 17.8 48.0 21.6 31.0 42.5 10.3 49.3 36.2 19.2 87.0 49.2 38.9 45.6 44.4 60.0 29.1 31.8 33.3 13.9 27.7 17.5 11.4 55.5 23.1 23.7 13.6 23.6 8.4 19.5 14.7 8.3 12.1 7.5 8.0 7.7 11.1 8.6 10.6 9.5 16.3 8.9 10.6 9.3 8.8 11.3 10.2 5.9 16.3 8.3 8.3 9.3 10.0 12.2 9.4 9.5 8.5 9.5 9.2 8.7 8.7 8.9 10.6 12.8 11.0 0.0 4.1 0.0 0.0 0.0 0.0 0.0 16.0 13.7 0.0 0.0 8.1 12.9 0.0 70.7 13.1 0.0 25.4 34.4 0.0 12.7 14.1 4.6 0.0 0.0 0.0 38.2 39.9 10.1 0.0 14.3 5.1 17.5 0.0 0.0 24.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.1 0.0 0.0 32.0 0.0 0.0 0.0 0.0 25.2 0.0 0.0 1.8 0.0 0.0 35.6 3.6 0.0 0.0 0.0 8.2 0.0 0.0 0.0 0.0 83.5 7.6 43.3 0.0 0.0 LACC1 "C13orf31, FAMIN, FLJ38725" ENSG00000179630 "Laccase domain containing 1" Q8IV20 13 43879284-43893932 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Immunity, Inflammatory response, Innate immunity" "Hydrolase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 27.4" "Cell type enhanced" "Detected in many" "Oligodendrocytes: 39.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "classical monocyte: 3.0;eosinophil: 3.1;intermediate monocyte: 5.2;myeloid DC: 2.7;non-classical monocyte: 8.0" "Group enriched" "Detected in many" 4 "dendritic cells: 2.7;granulocytes: 3.1;monocytes: 8.0" "Cell line enhanced" "Detected in many" "HMC-1: 37.1;TIME: 118.2" "Low region specificity" "Detected in all" "CAB034228, HPA040150, HPA044211" Uncertain NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 65: Brain - Ion transport" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 4: Macrophages - Innate immune response" "CAB034228: AB_1564163, HPA040150: AB_10963540, HPA044211: AB_10961258" "unprognostic (2.48e-1)" "unprognostic (3.27e-2)" "unprognostic (4.54e-2)" "unprognostic (3.31e-3)" "unprognostic (1.17e-2)" "unprognostic (3.90e-2)" "unprognostic (6.41e-3)" "unprognostic (4.43e-2)" "unprognostic (3.03e-3)" "unprognostic (1.78e-2)" "unprognostic (6.06e-3)" "unprognostic (2.02e-1)" "unprognostic (3.93e-2)" "unprognostic (3.30e-1)" "unprognostic (9.36e-3)" "unprognostic (2.22e-1)" "unprognostic (1.18e-1)" 6.4 6.6 12.7 12.2 22.3 1.9 5.4 10.8 20.6 4.5 6.8 10.3 9.9 3.9 3.2 6.8 3.2 9.8 10.1 11.7 13.6 4.8 7.2 6.4 8.8 13.9 14.5 3.4 3.5 9.9 2.8 6.1 15.2 5.4 13.3 0.8 4.6 4.9 1.4 4.8 13.8 5.8 12.5 7.2 6.8 9.4 17.3 6.5 3.5 1.2 8.3 11.1 2.9 27.4 4.7 2.5 1.3 0.0 2.7 12.3 9.5 10.3 25.7 2.8 3.9 5.3 10.5 9.9 2.3 13.8 6.0 6.7 0.3 2.9 4.5 6.6 1.7 12.3 2.6 1.9 12.5 2.9 37.1 16.3 8.5 10.3 12.6 3.4 5.9 1.1 0.0 7.1 6.4 2.3 0.3 3.7 0.9 2.6 2.2 2.3 0.0 5.2 7.4 5.5 1.6 2.5 3.4 1.2 4.9 6.8 1.5 6.2 118.2 3.5 1.1 18.8 0.1 0.0 0.0 2.4 10.0 3.7 8.0 1.0 3.0 3.1 0.7 5.2 0.8 0.8 0.6 0.6 2.7 1.0 0.2 0.3 0.1 0.4 8.0 0.5 0.8 1.0 12.7 22.3 10.8 20.6 11.7 13.6 13.9 14.5 15.2 12.5 17.3 27.4 4.6 12.8 6.8 1.0 5.9 5.7 8.4 8.1 3.4 0.5 5.1 4.6 24.2 4.3 7.8 11.0 0.0 6.5 1.0 7.6 1.9 5.5 1.3 5.1 3.4 7.4 5.4 1.7 2.1 3.8 4.3 4.5 2.0 8.5 8.2 9.7 5.0 5.1 15.3 0.0 6.2 4.4 6.1 17.6 10.3 3.1 2.1 24.2 1.8 1.9 7.8 2.0 1.0 2.0 39.2 8.0 11.2 1.5 0.5 11.4 10.5 8.2 7.2 0.2 6.6 5.3 6.0 17.1 16.7 8.4 10.2 9.2 4.3 4.6 6.7 10.2 LANCL1 "GPR69A, p40" ENSG00000115365 "LanC like 1" O43813 2 210431249-210477652 "Enzymes, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 140.7" "Cell type enhanced" "Detected in all" "Early spermatids: 140.5;Inhibitory neurons: 157.1;Oligodendrocytes: 599.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA034994 Enhanced Uncertain Microtubules NA NA 22000 "Cluster 44: Non-specific - Transcription" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Microtubules "HPA034994: AB_10601936" "unprognostic (2.34e-1)" "unprognostic (1.78e-1)" "unprognostic (1.24e-1)" "unprognostic (1.50e-2)" "unprognostic (1.98e-1)" "unprognostic (2.67e-2)" "unprognostic (2.02e-2)" "unprognostic (1.20e-1)" "unprognostic (6.10e-2)" "unprognostic (9.76e-2)" "unprognostic (2.82e-2)" "unprognostic (2.08e-1)" "unprognostic (2.13e-3)" "unprognostic (1.23e-1)" "unprognostic (9.27e-2)" "unprognostic (1.29e-1)" "unprognostic (1.06e-1)" 28.1 26.8 57.3 15.5 91.9 19.1 33.6 85.2 81.5 23.1 21.5 22.1 21.5 28.8 19.6 29.5 23.4 23.0 40.9 59.0 67.7 37.6 23.6 21.2 26.7 95.1 79.4 32.1 24.6 64.9 19.2 22.1 89.0 33.0 22.7 48.5 20.3 31.7 28.5 42.2 20.7 33.0 92.8 23.3 19.0 53.9 77.5 40.0 24.3 51.2 27.7 21.4 16.6 140.7 26.3 29.2 45.9 46.8 51.3 71.9 32.0 39.3 50.3 35.5 46.4 32.8 29.4 22.5 50.3 44.9 57.8 26.6 30.2 63.6 59.4 26.1 32.4 39.6 96.1 58.3 42.5 50.5 13.6 52.1 51.2 46.7 37.8 80.3 52.2 68.3 50.1 35.6 46.4 23.1 68.5 27.9 30.7 31.9 20.2 30.5 64.1 33.4 65.2 25.4 43.6 60.4 46.0 97.5 51.2 67.3 33.2 26.7 53.5 62.2 41.4 32.9 41.8 21.8 43.8 31.3 58.4 38.5 73.4 8.6 2.5 6.8 11.8 5.3 11.5 7.9 10.4 11.8 8.3 8.8 11.0 12.7 0.8 8.1 8.5 7.3 11.7 6.8 57.3 91.9 85.2 81.5 59.0 67.7 95.1 79.4 89.0 92.8 77.5 140.7 13.5 12.8 14.2 36.2 11.6 26.3 10.0 13.2 31.3 27.2 19.0 13.5 35.7 10.0 12.3 20.2 18.8 10.8 12.3 5.9 15.6 8.7 140.5 11.6 12.6 13.4 6.7 17.9 68.4 12.0 5.6 16.1 9.2 10.7 6.3 24.0 11.4 20.1 8.8 50.5 157.1 7.6 12.2 10.3 6.4 114.7 13.1 5.0 16.0 20.6 4.5 20.7 15.5 70.4 599.1 5.3 6.0 19.2 11.0 6.5 9.2 18.8 14.2 24.1 19.7 14.8 22.0 41.7 19.0 25.3 33.1 5.1 13.8 14.8 12.7 8.1 LATS1 WARTS ENSG00000131023 "Large tumor suppressor kinase 1" O95835 6 149658153-149718105 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Tumor suppressor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031804 Approved NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 34: Non-specific - Transcription" "Cluster 1: K-562 - Erythropoiesis" "Cluster 59: Non-specific - Transcription" "HPA031804: AB_10601688" "unprognostic (4.02e-3)" "unprognostic (3.80e-3)" "unprognostic (1.28e-2)" "unprognostic (1.00e-1)" "unprognostic (4.40e-2)" "unprognostic (2.09e-1)" "unprognostic (6.15e-3)" "unprognostic (1.29e-2)" "unprognostic (9.67e-2)" "unprognostic (1.02e-2)" "unprognostic (1.74e-1)" "unprognostic (1.52e-1)" "unprognostic (5.62e-2)" "unprognostic (1.92e-1)" "unprognostic (8.43e-2)" "unprognostic (2.63e-1)" "unprognostic (2.65e-1)" 8.1 8.0 4.8 8.6 4.9 15.4 9.2 11.0 7.0 10.1 5.5 7.3 7.2 12.1 7.4 8.2 9.7 7.7 5.6 5.2 4.6 7.7 7.8 9.1 9.8 4.7 4.3 15.6 6.8 11.7 5.2 8.8 5.0 11.0 8.5 11.0 8.7 7.7 6.4 9.1 7.7 10.7 4.3 10.2 7.7 6.2 5.1 11.7 8.9 8.1 8.4 9.0 7.2 7.6 8.7 6.8 13.7 19.8 12.9 16.6 10.7 11.3 11.4 11.8 11.7 11.1 7.3 14.0 11.1 15.7 9.4 11.8 18.3 12.0 18.5 12.9 14.7 28.1 8.2 9.9 11.9 26.5 19.8 11.3 19.1 13.5 22.7 12.2 14.8 12.1 35.3 13.9 11.9 10.4 13.8 11.0 8.5 8.0 6.5 13.6 16.4 6.5 11.0 12.2 9.3 14.7 16.1 11.5 8.4 9.3 12.0 22.9 18.7 9.5 14.8 11.4 18.2 11.6 13.5 15.8 8.7 14.8 14.3 8.2 3.0 4.8 5.9 5.3 5.3 3.8 4.5 5.0 3.3 4.7 3.8 5.1 2.0 3.0 8.9 2.8 4.8 2.4 4.8 4.9 11.0 7.0 5.2 4.6 4.7 4.3 5.0 4.3 5.1 7.6 21.1 12.8 21.3 33.0 21.9 16.3 11.2 9.7 27.9 20.3 15.2 10.2 9.6 12.8 12.5 7.3 18.8 8.5 18.7 15.3 1.9 7.5 23.0 14.1 23.4 16.2 16.8 17.7 51.4 6.6 11.4 19.7 20.9 17.1 14.0 19.8 21.0 13.3 11.0 13.5 48.0 12.6 6.1 14.7 11.6 6.9 13.7 16.6 14.2 32.8 15.0 10.7 10.3 54.8 64.0 9.9 11.5 25.9 21.9 15.4 13.6 6.6 12.8 22.0 19.7 28.8 15.1 8.8 9.6 18.8 18.0 13.1 23.3 13.8 11.7 11.8 LATS2 ENSG00000150457 "Large tumor suppressor kinase 2" Q9NRM7 13 20973036-21061586 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 139.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039191, HPA049037" Approved Supported "Centriolar satellite,Cytosol" NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 44: Endometrium - Transcription" "Centriolar satellite, Cytosol" "HPA039191: AB_2676385, HPA049037: AB_2680609" "unprognostic (2.77e-1)" "prognostic unfavorable (3.26e-4)" "unprognostic (6.22e-3)" "unprognostic (3.38e-2)" "unprognostic (2.51e-2)" "unprognostic (1.84e-2)" "unprognostic (1.88e-1)" "unprognostic (2.16e-3)" "unprognostic (4.48e-1)" "unprognostic (6.57e-3)" "unprognostic (8.03e-2)" "unprognostic (4.92e-2)" "unprognostic (7.85e-2)" "unprognostic (1.66e-2)" "unprognostic (1.25e-1)" "unprognostic (7.97e-2)" "unprognostic (1.11e-2)" 19.8 12.2 3.9 7.3 4.3 15.1 12.4 4.8 3.7 10.1 7.7 13.1 2.9 12.2 3.0 11.5 9.7 15.1 11.5 5.3 3.3 9.9 9.8 12.4 5.3 5.4 4.6 11.0 10.2 4.3 2.3 13.9 4.5 9.8 4.3 1.3 6.1 8.8 16.7 7.7 6.2 13.1 4.1 11.2 7.8 14.6 5.1 2.4 13.5 13.3 3.3 14.2 8.9 4.7 6.8 7.4 16.0 9.7 18.4 24.1 14.6 22.1 22.8 22.5 19.2 21.1 10.0 0.0 10.5 33.8 8.8 9.6 9.5 10.1 33.1 3.8 2.5 12.4 9.4 16.0 28.6 3.4 4.2 36.0 18.1 14.9 9.9 11.3 32.0 2.8 2.3 0.5 28.9 11.7 0.4 11.6 3.8 7.0 3.5 2.9 28.5 0.0 16.3 3.1 0.3 0.0 17.4 11.3 23.9 13.9 9.8 6.4 40.6 23.8 15.9 17.7 14.1 2.9 1.7 0.0 5.7 3.8 18.6 0.1 0.5 0.5 0.4 0.4 0.9 0.0 0.0 0.1 0.4 0.0 0.0 0.0 0.9 0.4 0.2 0.0 0.0 0.1 3.9 4.3 4.8 3.7 5.3 3.3 5.4 4.6 4.5 4.1 5.1 4.7 36.6 41.7 9.9 12.1 2.8 32.9 14.7 8.5 21.6 0.4 12.5 11.0 24.3 15.7 10.5 5.5 0.0 24.8 21.0 6.5 3.9 10.1 139.4 40.3 30.4 35.1 0.0 8.2 0.6 7.3 8.9 37.2 8.6 62.1 5.1 9.8 44.6 19.6 9.9 0.0 0.6 1.9 6.1 17.9 49.3 13.7 25.4 26.0 17.8 21.5 11.0 4.9 13.4 2.0 8.8 18.6 2.8 34.6 8.9 21.7 0.6 9.5 11.6 1.0 6.6 32.3 30.0 8.8 14.5 9.9 25.3 48.0 8.1 7.9 1.5 15.2 LCAT ENSG00000213398 "Lecithin-cholesterol acyltransferase" P04180 16 67939750-67944131 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism" "Acyltransferase, Hydrolase, Transferase" "Corneal dystrophy, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 5 "liver: 283.0" "Cell type enriched" "Detected in many" 8 "Hepatocytes: 219.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "eosinophil: 1.9" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "BEWO: 76.5;Hep G2: 62.9" "Low region specificity" "Detected in all" "Region enhanced" "Detected in many" "cerebellum: 29.2" HPA044767 Approved Nucleoplasm "Secreted to blood" NA NA 6470000000 6400000000 "Cluster 52: Eosinophils - Transcription" "Cluster 15: Liver - Metabolism" "Cluster 28: BEWO - Transcription regulation" "Cluster 15: Hepatocytes - Hemostasis" Nucleoplasm "HPA044767: AB_2756312" "unprognostic (3.34e-2)" "unprognostic (3.56e-2)" "prognostic unfavorable (8.50e-4)" "unprognostic (5.43e-3)" "unprognostic (1.25e-2)" "unprognostic (2.16e-1)" "prognostic favorable (4.21e-8)" "unprognostic (6.42e-2)" "unprognostic (4.26e-1)" "unprognostic (4.12e-1)" "unprognostic (1.50e-2)" "unprognostic (7.21e-2)" "prognostic unfavorable (1.71e-4)" "unprognostic (9.93e-2)" "unprognostic (1.83e-1)" "unprognostic (2.85e-1)" "unprognostic (1.90e-3)" 29.5 20.8 29.3 8.3 29.8 4.2 27.2 56.7 37.5 41.4 37.8 30.6 5.0 28.7 9.1 13.4 26.1 11.5 42.0 28.5 32.3 33.2 283.0 36.1 7.5 41.9 32.7 28.5 17.7 8.0 17.5 17.8 31.6 40.0 4.8 2.8 16.9 18.6 13.2 32.0 17.8 12.3 31.9 23.3 16.5 11.3 33.4 9.4 43.2 8.9 4.4 27.5 27.3 32.0 5.7 9.0 13.0 14.8 11.1 15.6 76.5 21.9 9.3 14.5 10.2 29.5 6.8 3.1 4.0 31.9 5.3 19.4 3.1 30.0 8.9 1.5 7.9 3.9 22.8 62.9 15.2 0.7 10.3 27.1 27.9 30.0 10.4 19.5 10.8 8.7 8.7 1.2 10.5 9.1 3.7 9.5 8.6 1.1 5.0 4.0 14.1 3.3 4.1 9.6 0.5 6.7 33.1 1.6 3.9 26.5 18.6 6.0 20.6 18.5 28.8 20.7 8.1 17.7 5.2 8.3 8.9 2.5 16.5 0.9 0.4 1.9 0.3 0.0 0.4 0.4 0.2 0.3 0.1 0.6 0.4 0.1 1.0 0.4 0.1 0.3 0.0 0.0 29.3 29.8 56.7 37.5 28.5 32.3 41.9 32.7 31.6 31.9 33.4 32.0 16.5 9.6 4.8 27.4 1.1 9.4 4.1 4.6 6.8 0.4 1.9 5.5 7.9 5.7 3.3 3.7 2.1 7.7 1.3 0.1 0.0 1.7 0.2 2.1 6.0 8.0 1.2 14.3 0.1 1.0 3.4 7.3 1.1 1.6 1.3 5.4 10.8 219.5 2.4 0.0 0.1 0.0 4.1 6.6 3.8 1.3 8.7 2.4 7.2 6.5 3.0 7.7 1.0 4.5 1.4 2.1 0.0 8.6 1.9 4.3 0.0 0.4 4.4 0.6 13.1 7.6 10.4 0.9 1.4 0.9 2.6 12.2 1.6 4.1 0.1 1.7 LCK ENSG00000182866 "LCK proto-oncogene, Src family tyrosine kinase" P06239 1 32251239-32286165 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Host-virus interaction" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 15 "lymphoid tissue: 343.0" "Group enriched" "Detected in many" 9 "dendritic cells: 143.9;NK-cells: 272.9;T-cells: 255.5" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Group enriched" "Detected in all" 12 "gdT-cell: 1109.8;MAIT T-cell: 1034.8;memory CD4 T-cell: 1123.8;memory CD8 T-cell: 1201.7;naive CD4 T-cell: 1260.7;naive CD8 T-cell: 1168.7;NK-cell: 641.5;T-reg: 1682.7" "Group enriched" "Detected in all" 12 "NK-cells: 641.5;T-cells: 1682.7" "Group enriched" "Detected in some" 6 "JURKAT: 365.7;MOLT-4: 536.9;U-698: 302.7" "Low region specificity" "Detected in some" "Low region specificity" "Detected in single" "HPA003494, CAB003816" Enhanced Approved "Golgi apparatus" NA NA "Cluster 20: T-cells - T-cell receptor" "Cluster 63: T-cells - Adaptive immune response" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 63: NK-cells & T-cells - Immune response" "Golgi apparatus" "CAB003816: AB_562158, HPA003494: AB_1852751" "unprognostic (6.38e-3)" "unprognostic (5.45e-3)" "unprognostic (8.39e-2)" "prognostic favorable (2.96e-6)" "unprognostic (2.20e-2)" "prognostic favorable (2.91e-4)" "unprognostic (4.78e-3)" "unprognostic (1.33e-2)" "prognostic favorable (5.65e-5)" "unprognostic (3.07e-2)" "unprognostic (3.80e-2)" "unprognostic (2.83e-1)" "prognostic unfavorable (2.60e-5)" "unprognostic (8.15e-2)" "unprognostic (4.05e-2)" "unprognostic (7.39e-2)" "unprognostic (1.17e-2)" 3.4 2.2 0.4 50.6 0.5 13.7 2.3 0.4 0.5 2.2 0.7 6.9 7.6 1.7 13.0 3.9 2.1 9.4 1.9 0.5 0.4 3.8 3.8 11.4 111.0 0.8 0.5 1.6 0.9 0.5 0.8 1.1 0.6 2.8 6.5 0.0 4.8 1.4 1.3 1.9 23.1 2.3 0.6 39.9 12.1 1.1 0.5 343.0 3.7 1.4 79.6 13.2 2.7 0.6 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.6 0.7 64.1 3.5 0.0 0.3 0.1 0.0 0.2 0.0 0.1 0.6 0.0 0.0 1.4 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 365.7 0.2 0.0 0.0 0.0 536.9 0.2 5.9 4.6 0.3 20.6 0.1 0.3 0.3 0.2 0.1 0.0 0.1 0.3 0.3 0.4 0.6 0.4 0.0 0.0 1.7 0.1 0.1 0.7 0.3 302.7 0.0 0.1 0.0 12.8 5.2 6.0 1109.8 4.9 1034.8 62.0 1123.8 1201.7 5.2 98.9 1260.7 1168.7 33.6 641.5 6.0 7.7 1682.7 1836.9 0.4 0.5 0.4 0.5 0.5 0.4 0.8 0.5 0.6 0.6 0.5 0.6 4.9 0.0 9.3 0.0 23.4 4.6 1.2 0.4 0.0 0.0 3.5 5.2 1.8 4.3 1.6 3.7 0.0 0.3 143.9 0.9 0.0 0.6 0.1 1.0 0.5 3.4 2.4 10.1 0.2 0.5 0.2 3.1 7.7 0.7 5.1 0.0 4.6 1.5 0.3 0.0 0.2 0.3 0.0 7.8 7.3 0.0 0.0 8.1 3.6 0.0 8.7 0.0 272.9 0.5 0.1 4.7 0.0 0.4 15.7 1.0 0.0 1.4 1.8 0.0 0.0 1.5 2.4 4.5 2.0 0.5 3.1 0.4 255.5 2.9 1.3 1.1 LCLAT1 "AGPAT8, ALCAT1, FLJ37965, LYCAT" ENSG00000172954 "Lysocardiolipin acyltransferase 1" Q6UWP7 2 30447226-30644225 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Developmental protein, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 67.3;Inhibitory neurons: 86.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031880, HPA049217" Uncertain Supported "Endoplasmic reticulum,Cytosol" NA NA "Cluster 34: Basophils - Unknown function" "Cluster 6: Brain - Smell perception" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Endoplasmic reticulum" Cytosol "HPA031880: AB_10610002, HPA049217: AB_2680678" "unprognostic (6.60e-2)" "unprognostic (2.47e-1)" "unprognostic (1.12e-1)" "unprognostic (9.52e-3)" "unprognostic (4.10e-1)" "prognostic unfavorable (9.67e-4)" "prognostic unfavorable (8.72e-4)" "unprognostic (2.03e-1)" "unprognostic (1.33e-1)" "unprognostic (3.88e-2)" "unprognostic (7.11e-3)" "unprognostic (2.85e-2)" "unprognostic (4.14e-2)" "unprognostic (1.07e-1)" "unprognostic (1.63e-1)" "unprognostic (3.93e-3)" "unprognostic (1.10e-1)" 4.2 4.9 6.1 5.0 6.7 9.9 5.3 10.8 9.3 6.7 3.4 7.8 12.3 7.2 9.8 5.1 6.1 6.2 11.3 5.3 7.8 9.5 8.6 5.1 5.4 2.9 3.3 4.9 5.9 6.3 3.2 4.3 3.1 7.8 7.9 10.6 4.6 7.0 9.6 6.6 9.5 8.7 0.8 5.3 5.3 8.3 7.0 6.4 10.9 4.1 5.4 4.9 3.7 10.2 16.9 21.6 11.3 19.3 2.6 5.7 16.3 11.8 11.7 12.3 10.3 21.8 19.0 10.5 10.7 18.4 15.2 18.3 38.8 16.0 12.1 13.6 13.0 19.4 12.8 21.6 12.0 28.1 14.3 4.6 12.4 13.0 18.0 8.0 8.7 6.0 18.3 9.5 9.6 12.8 16.1 16.5 12.5 13.6 12.4 15.6 22.9 21.8 9.7 24.7 13.1 20.5 26.4 17.4 15.7 7.7 12.6 9.5 10.0 22.1 18.2 12.4 18.9 7.0 16.2 23.2 22.7 20.1 17.3 15.9 2.3 5.0 5.2 3.8 6.2 7.5 8.3 6.7 2.8 9.7 11.7 11.5 7.2 4.6 3.6 2.0 4.2 3.0 6.1 6.7 10.8 9.3 5.3 7.8 2.9 3.3 3.1 0.8 7.0 10.2 6.5 9.6 6.9 27.1 11.4 7.1 5.0 8.4 6.8 15.5 6.9 5.3 20.1 18.6 8.7 14.7 27.1 5.2 6.7 10.4 0.0 7.7 3.9 12.0 7.0 7.7 13.1 10.3 67.3 16.4 5.3 6.7 3.1 9.4 3.8 11.6 8.6 21.5 6.1 15.2 86.8 14.3 0.0 5.7 3.9 1.4 5.6 3.4 5.4 45.0 2.4 7.9 5.2 50.8 37.3 12.9 8.6 9.1 5.2 5.4 21.4 12.1 16.6 18.2 6.6 10.9 16.3 13.9 21.0 7.9 6.7 1.9 9.1 10.9 17.0 4.7 LCMT1 "CGI-68, PPMT1" ENSG00000205629 "Leucine carboxyl methyltransferase 1" Q9UIC8 16 25111731-25178231 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Granulosa cells: 197.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041559, HPA043530" Uncertain Approved Nucleoplasm,Cytosol NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 80: Striated muscle - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 40: Granulosa cells - Unknown function" "Nucleoplasm, Cytosol" "HPA041559: AB_2677548, HPA043530: AB_2678532" "unprognostic (9.08e-2)" "prognostic favorable (2.78e-4)" "unprognostic (1.18e-1)" "unprognostic (3.71e-1)" "unprognostic (3.15e-1)" "unprognostic (1.73e-1)" "prognostic unfavorable (5.85e-4)" "unprognostic (1.41e-2)" "unprognostic (7.41e-2)" "unprognostic (4.45e-2)" "unprognostic (4.62e-2)" "unprognostic (1.16e-1)" "prognostic favorable (7.53e-6)" "unprognostic (1.23e-1)" "unprognostic (8.99e-2)" "unprognostic (1.84e-3)" "unprognostic (6.71e-2)" 17.5 27.3 41.5 13.3 43.2 19.9 22.5 41.1 44.5 23.9 36.5 22.0 16.8 21.2 31.1 22.8 20.5 13.6 36.1 45.1 42.8 26.9 10.9 14.9 16.7 39.9 39.0 28.1 47.2 32.0 32.9 24.1 42.4 20.8 21.3 21.8 21.2 21.3 52.3 28.2 17.1 18.5 40.2 16.2 22.5 35.4 43.4 21.3 18.6 36.2 20.2 18.1 20.6 43.0 40.3 36.3 33.9 47.2 30.2 42.9 34.9 24.7 40.5 35.7 45.9 46.4 35.7 24.4 34.1 37.6 44.2 20.1 35.9 34.3 47.9 24.9 53.3 13.5 35.4 77.3 67.9 32.0 20.9 48.7 37.7 39.9 41.4 51.3 32.3 54.0 21.5 31.2 39.5 102.3 37.9 60.6 52.1 25.3 37.0 44.3 30.9 47.7 40.7 27.9 55.5 34.1 29.0 45.8 58.2 39.9 46.0 14.9 19.1 34.6 24.3 23.4 25.0 39.8 43.9 25.8 42.3 27.5 26.6 33.4 36.5 46.2 39.4 33.5 43.3 42.0 47.8 42.1 35.0 31.6 42.8 39.2 14.6 33.6 37.6 18.1 82.9 42.2 41.5 43.2 41.1 44.5 45.1 42.8 39.9 39.0 42.4 40.2 43.4 43.0 21.0 16.0 19.8 15.3 23.5 24.1 31.1 55.6 33.6 25.7 39.3 42.0 34.8 15.7 29.6 33.1 2.1 164.5 20.9 60.5 49.0 51.7 76.5 22.7 31.4 22.7 51.4 29.5 29.0 66.7 69.4 29.1 20.9 20.2 9.5 197.7 23.2 9.5 46.8 23.5 30.1 46.9 38.7 33.9 20.0 137.5 26.1 27.0 33.8 17.8 31.3 32.0 32.0 28.1 31.7 46.7 45.1 24.0 28.9 34.6 79.4 90.0 30.0 26.1 26.3 22.9 67.7 67.3 52.9 35.6 31.8 163.8 29.6 78.7 43.7 34.7 LCMT2 "KIAA0547, MGC9534, PPM2, TYW4" ENSG00000168806 "Leucine carboxyl methyltransferase 2" O60294 15 43323649-43330582 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "tRNA processing" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Spermatocytes: 23.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" HPA039401 Approved Approved Cytosol NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" Cytosol "HPA039401: AB_10805478" "unprognostic (4.32e-2)" "unprognostic (1.44e-1)" "unprognostic (1.55e-1)" "unprognostic (4.11e-2)" "unprognostic (1.99e-1)" "unprognostic (2.27e-1)" "unprognostic (9.08e-2)" "unprognostic (5.14e-2)" "unprognostic (3.52e-2)" "unprognostic (2.20e-1)" "unprognostic (3.33e-3)" "unprognostic (9.57e-2)" "prognostic favorable (5.69e-9)" "unprognostic (2.28e-1)" "unprognostic (3.21e-2)" "unprognostic (1.62e-2)" "unprognostic (1.57e-1)" 5.1 4.7 5.3 4.8 5.2 1.9 6.3 6.8 10.2 6.3 6.4 4.8 3.4 6.0 7.6 5.0 6.3 3.1 5.5 5.0 6.2 7.3 6.0 4.0 6.5 5.1 5.2 5.7 3.8 8.0 4.2 3.6 5.5 6.2 4.6 7.3 3.9 6.4 4.0 3.8 4.3 5.3 5.2 4.4 4.1 3.9 5.2 7.8 5.7 4.7 9.2 5.2 3.2 5.3 8.8 6.7 15.7 13.7 16.3 5.1 7.7 10.7 12.3 13.2 14.6 10.2 4.0 7.5 20.8 12.0 14.2 20.0 0.0 13.8 10.1 11.6 7.3 13.3 18.3 5.9 9.9 0.0 9.8 7.8 13.0 9.8 9.0 8.9 4.3 16.9 17.1 9.6 16.1 13.4 15.4 6.3 6.8 19.0 5.8 17.8 13.7 7.2 23.4 9.8 21.1 17.6 13.8 11.6 6.0 12.1 14.1 20.2 3.7 15.6 7.1 18.1 17.4 6.5 16.6 3.0 9.7 10.9 16.5 1.7 2.6 3.8 2.3 2.4 3.3 3.2 3.9 2.9 4.4 3.5 6.0 4.1 0.8 2.0 2.2 2.6 3.3 3.2 5.3 5.2 6.8 10.2 5.0 6.2 5.1 5.2 5.5 5.2 5.2 5.3 1.5 0.0 3.1 1.3 3.5 3.1 3.7 1.9 1.8 7.6 2.9 2.8 3.6 5.7 5.7 3.7 8.4 4.3 2.7 2.8 3.9 6.5 2.1 3.6 3.9 3.1 5.4 4.8 1.1 4.0 2.3 3.7 2.0 4.1 1.3 2.2 5.0 4.1 2.7 3.3 1.6 2.2 4.1 1.3 0.8 1.5 5.0 2.7 0.0 1.9 2.4 7.3 4.1 0.5 1.7 3.4 2.1 1.5 2.5 3.3 1.8 4.7 6.2 6.6 6.6 5.1 3.7 23.4 10.5 2.7 2.8 2.5 2.6 2.4 3.3 2.8 LFNG SCDO3 ENSG00000106003 "LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" Q8NES3 7 2512529-2529177 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Developmental protein, Glycosyltransferase, Transferase" "Disease variant, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "pancreas: 74.4" "Cell type enhanced" "Detected in many" "dendritic cells: 40.3;Enteroendocrine cells: 87.4;monocytes: 38.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "CAPAN-2: 37.7;OE19: 46.4;RH-30: 46.0;U-2 OS: 49.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA069130 Approved Approved "Nuclear membrane,Golgi apparatus" "Intracellular and membrane" NA NA 880000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 22: Non-specific - Unknown function" "Cluster 21: OE19 - Mitochondria" "Cluster 41: Macrophages - Immune response" "Golgi apparatus" "Nuclear membrane" "HPA069130: AB_2686091" "unprognostic (4.58e-2)" "unprognostic (1.17e-2)" "unprognostic (2.52e-2)" "prognostic favorable (6.36e-4)" "unprognostic (1.85e-2)" "unprognostic (8.34e-2)" "unprognostic (4.15e-1)" "unprognostic (7.86e-2)" "unprognostic (1.91e-1)" "unprognostic (2.25e-1)" "unprognostic (8.55e-3)" "unprognostic (1.89e-1)" "unprognostic (5.16e-3)" "unprognostic (5.40e-2)" "unprognostic (1.09e-1)" "unprognostic (1.97e-2)" "unprognostic (2.28e-2)" 16.7 6.5 23.3 17.3 25.9 9.8 13.7 29.3 22.4 9.9 11.1 23.1 15.5 9.4 2.2 11.4 6.1 11.8 13.1 17.4 30.1 9.0 2.5 14.4 18.6 34.1 35.6 1.8 74.4 3.0 3.7 6.5 24.8 17.1 12.0 3.0 33.4 4.6 4.6 58.2 17.2 5.8 25.0 20.9 37.8 4.2 38.1 5.8 6.7 3.6 10.8 12.2 13.8 23.6 1.5 14.3 18.4 2.5 2.0 1.7 1.2 5.4 2.8 4.7 5.9 6.0 37.7 1.1 16.7 14.8 8.1 27.1 2.9 5.1 2.3 8.6 0.6 4.3 7.7 3.2 0.1 6.2 7.7 3.3 12.6 7.8 0.8 3.2 1.9 0.3 0.7 0.2 3.6 34.5 0.1 8.7 22.4 46.4 10.3 1.8 46.0 2.9 1.8 4.5 16.9 4.2 6.2 1.4 0.3 4.7 10.2 7.3 4.5 10.5 49.7 0.4 15.4 0.2 0.0 1.4 11.8 16.4 2.0 6.3 5.3 12.7 1.8 6.9 2.0 1.1 1.7 0.9 2.3 2.0 1.8 1.8 2.8 1.3 6.6 0.6 4.2 1.7 23.3 25.9 29.3 22.4 17.4 30.1 34.1 35.6 24.8 25.0 38.1 23.6 23.3 6.4 6.0 18.9 15.6 6.8 2.5 10.6 3.4 8.5 5.3 12.4 3.6 5.7 2.8 0.0 0.0 0.1 40.3 23.1 0.0 1.2 0.1 2.4 8.5 16.0 87.4 2.7 0.0 6.4 0.3 5.7 30.5 1.2 17.7 0.1 13.9 0.6 7.0 0.0 0.1 34.5 6.1 30.4 13.8 0.5 1.8 30.6 3.6 11.2 38.2 31.3 19.6 1.5 0.1 21.7 3.1 0.0 12.6 2.2 8.8 0.4 1.2 0.8 0.0 0.6 5.0 0.3 3.1 0.6 4.0 0.0 15.9 0.5 15.3 0.7 LIAS LAS ENSG00000121897 "Lipoic acid synthetase" O43766 4 39459004-39485109 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Transferase "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 86.0;Late spermatids: 100.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018842, HPA019076" Approved Supported Approved Nucleoplasm,Mitochondria Yes No "Cluster 30: Non-specific - Translation" "Cluster 80: Striated muscle - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm Mitochondria "HPA018842: AB_1852864, HPA019076: AB_1852866" "unprognostic (3.61e-1)" "unprognostic (1.89e-1)" "unprognostic (8.44e-2)" "unprognostic (2.33e-1)" "unprognostic (4.87e-2)" "unprognostic (1.49e-1)" "unprognostic (8.31e-2)" "unprognostic (1.57e-1)" "unprognostic (4.19e-2)" "unprognostic (3.68e-2)" "unprognostic (2.46e-3)" "unprognostic (3.80e-2)" "prognostic favorable (4.11e-7)" "unprognostic (9.41e-3)" "unprognostic (2.35e-1)" "unprognostic (5.45e-2)" "unprognostic (6.98e-2)" 5.4 7.5 5.9 3.0 6.5 6.6 5.7 7.6 9.8 5.1 5.9 6.4 5.5 4.6 5.3 6.7 6.1 3.6 11.1 6.2 6.7 8.7 8.6 2.9 5.1 6.3 6.4 10.0 6.8 6.5 4.0 3.3 6.8 4.1 6.4 5.4 4.3 3.1 27.2 5.7 5.2 5.2 5.5 3.6 6.3 9.8 6.2 4.3 4.2 21.0 4.2 5.8 4.7 8.3 5.7 4.5 5.4 5.2 11.5 11.4 4.8 6.6 3.7 6.1 4.1 6.8 7.8 20.8 7.3 2.5 15.2 4.9 15.9 9.1 8.0 2.4 4.0 8.8 2.3 7.0 10.4 19.1 5.5 10.8 14.6 7.1 22.4 13.4 7.0 12.7 21.1 5.2 7.5 3.6 10.9 24.9 7.3 15.3 14.2 9.1 15.2 12.9 7.1 2.9 6.0 4.8 3.8 4.9 22.5 7.6 5.6 8.8 2.6 4.7 10.6 6.3 15.5 9.9 15.8 14.3 7.2 22.2 4.0 2.5 6.4 3.9 5.7 7.6 12.7 10.0 8.1 8.0 6.2 7.6 16.2 11.6 3.4 7.7 5.6 5.5 5.7 4.7 5.9 6.5 7.6 9.8 6.2 6.7 6.3 6.4 6.8 5.5 6.2 8.3 11.0 9.6 12.6 14.0 12.9 9.7 11.6 17.4 12.0 25.8 15.7 17.3 20.1 17.2 12.7 18.4 10.4 24.0 22.6 12.9 21.5 13.2 86.0 11.2 15.8 10.3 18.1 12.4 11.9 6.4 18.2 10.4 9.2 10.3 17.7 19.0 11.4 19.0 17.5 10.1 18.8 13.5 18.3 13.5 7.8 100.1 10.2 11.4 1.8 6.5 17.6 15.4 16.5 14.6 22.9 10.3 10.1 12.4 5.8 6.6 18.3 32.6 14.1 26.7 0.0 10.8 20.5 64.9 25.1 13.7 9.2 9.6 14.2 19.0 18.4 8.8 LIMK1 LIMK ENSG00000106683 "LIM domain kinase 1" P53667 7 74082933-74122525 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Williams-Beuren syndrome" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 77.9" "Cell type enhanced" "Detected in many" "Granulosa cells: 27.6;Horizontal cells: 35.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-87 MG: 136.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028516, HPA073571" Approved Supported "Nuclear speckles,Cytosol" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 70: Brain - Nervous system development" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 4: Macrophages - Innate immune response" "Nuclear speckles, Cytosol" "HPA028516: AB_10601751, HPA073571: " "unprognostic (1.45e-2)" "unprognostic (2.75e-1)" "prognostic unfavorable (4.95e-5)" "unprognostic (2.77e-2)" "unprognostic (1.40e-3)" "unprognostic (3.35e-2)" "prognostic unfavorable (7.79e-6)" "unprognostic (1.90e-2)" "unprognostic (2.16e-1)" "unprognostic (1.18e-1)" "unprognostic (3.32e-2)" "unprognostic (3.16e-2)" "prognostic unfavorable (6.63e-8)" "unprognostic (4.14e-2)" "unprognostic (7.00e-2)" "unprognostic (3.84e-2)" "unprognostic (5.79e-2)" 11.1 10.5 31.1 18.7 32.7 6.8 9.4 28.3 77.9 21.4 0.2 8.9 6.6 13.1 3.5 11.3 7.3 10.1 9.4 35.0 43.8 10.8 4.6 13.2 23.5 75.5 40.0 13.2 11.4 5.8 13.9 7.3 73.0 12.3 4.1 4.0 17.9 8.2 23.7 11.4 12.1 7.1 31.8 22.3 9.2 15.6 59.1 8.1 11.2 7.8 18.2 13.1 14.7 38.3 47.4 37.2 27.2 45.4 35.1 47.0 20.0 28.8 27.3 22.6 25.4 21.3 45.6 30.2 12.7 35.5 76.9 28.1 10.1 17.8 8.6 53.7 18.6 23.2 13.1 24.6 40.5 17.2 81.4 46.8 15.6 18.5 9.6 68.3 34.4 20.9 15.1 9.0 28.8 41.4 14.8 31.4 52.1 16.6 23.7 21.1 43.3 18.2 26.5 10.1 10.7 25.2 18.6 43.7 23.5 29.7 13.9 15.4 41.1 36.0 33.7 94.5 47.7 10.2 12.5 54.9 136.5 12.4 25.2 0.1 6.1 3.5 1.8 6.0 1.4 3.4 0.4 1.2 7.0 1.7 0.1 0.5 0.5 5.8 3.8 0.7 0.3 3.3 31.1 32.7 28.3 77.9 35.0 43.8 75.5 40.0 73.0 31.8 59.1 38.3 2.9 3.2 2.7 7.5 14.4 2.9 5.2 6.6 1.8 6.6 7.7 6.9 3.4 7.2 3.8 1.8 2.1 2.5 11.9 2.9 0.0 6.6 1.2 2.7 9.7 4.1 2.4 0.4 15.4 6.5 6.3 9.2 3.1 5.1 5.7 27.6 3.3 2.1 25.0 35.3 20.8 2.7 0.0 13.5 10.8 2.2 7.2 15.6 3.6 6.5 14.9 3.5 22.6 6.6 2.4 13.5 2.3 6.0 10.0 9.0 0.3 2.8 3.1 3.3 0.0 5.3 4.5 3.4 11.5 1.8 3.1 3.7 11.1 6.9 2.4 7.2 LIMK2 ENSG00000182541 "LIM domain kinase 2" P53671 22 31212239-31280080 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 115.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 4 "eosinophil: 40.0;neutrophil: 96.9" "Lineage enriched" "Detected in all" 6 "granulocytes: 96.9" "Cell line enhanced" "Detected in all" "BEWO: 135.5;hTCEpi: 251.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008183, CAB019313, HPA053882" Approved Supported Nucleoplasm,Cytosol NA Yes "Cluster 5: Granulocytes - Unknown function" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm Cytosol "CAB019313: , HPA008183: AB_1079252, HPA053882: AB_2682291" "unprognostic (1.79e-1)" "unprognostic (1.95e-1)" "unprognostic (1.04e-2)" "unprognostic (2.59e-2)" "unprognostic (1.39e-1)" "unprognostic (2.42e-2)" "unprognostic (4.02e-2)" "unprognostic (5.99e-2)" "unprognostic (1.21e-1)" "unprognostic (2.95e-1)" "unprognostic (3.96e-1)" "unprognostic (1.43e-1)" "prognostic unfavorable (4.57e-6)" "unprognostic (4.48e-2)" "unprognostic (1.48e-2)" "unprognostic (5.72e-2)" "unprognostic (1.37e-1)" 20.1 14.4 25.5 39.8 27.3 53.8 30.9 25.8 22.1 26.4 32.6 34.0 21.2 17.0 7.7 71.8 34.2 21.3 14.3 20.8 27.7 27.7 33.0 46.8 23.2 37.8 34.2 21.6 28.8 27.0 21.9 48.0 32.8 36.7 34.7 25.5 50.7 19.1 18.8 71.5 29.3 15.9 32.7 37.5 30.0 19.2 33.6 21.3 42.0 9.2 17.8 25.7 45.3 33.1 26.6 4.4 17.9 10.0 7.6 8.8 135.5 17.2 8.0 16.9 14.2 22.7 12.2 25.8 29.9 26.0 8.1 52.6 20.9 90.3 10.6 19.1 22.8 18.8 21.1 24.7 11.4 35.1 33.1 14.3 251.5 13.7 41.0 114.5 43.6 20.6 10.7 18.2 23.3 20.9 21.5 12.0 16.7 68.3 6.7 28.1 30.0 14.3 19.6 62.3 22.8 20.4 13.0 82.1 35.1 54.8 68.7 13.9 26.6 15.1 23.5 8.3 16.3 10.0 16.2 22.4 9.6 16.4 6.6 5.8 5.1 40.0 3.1 3.5 5.9 2.0 5.7 4.3 1.9 2.4 5.6 4.4 96.9 6.7 1.4 4.4 15.2 4.4 25.5 27.3 25.8 22.1 20.8 27.7 37.8 34.2 32.8 32.7 33.6 33.1 19.5 32.1 17.9 16.3 5.2 35.9 37.7 24.8 59.2 9.4 18.0 23.2 25.1 10.0 32.6 5.5 20.9 69.8 15.3 39.3 3.9 13.0 1.4 49.6 19.2 22.4 13.2 10.3 6.4 45.0 52.4 7.6 48.9 41.6 23.5 8.6 14.3 7.1 18.2 3.3 11.3 42.8 18.3 8.9 8.2 1.6 4.4 13.8 3.6 16.9 5.4 16.6 2.1 2.5 15.5 25.9 21.2 4.5 6.2 27.1 12.0 10.5 36.3 22.8 19.7 7.5 17.2 15.6 18.4 46.1 39.1 115.5 9.3 7.1 51.7 29.9 LIPT2 ENSG00000175536 "Lipoyl(octanoyl) transferase 2" A6NK58 11 74490519-74493724 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Acyltransferase, Ligase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 12.3" "Cell type enhanced" "Detected in many" "Early spermatids: 55.4;Late spermatids: 29.4;Proximal tubular cells: 17.7;Spermatocytes: 46.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA040249 Approved NA NA "Cluster 30: Non-specific - Translation" "Cluster 23: Testis - Cell cycle regulation" "Cluster 21: OE19 - Mitochondria" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA040249: AB_10795275" "unprognostic (8.80e-2)" "unprognostic (9.67e-2)" "unprognostic (5.12e-3)" "unprognostic (1.09e-1)" "unprognostic (6.74e-3)" "unprognostic (1.43e-1)" "unprognostic (1.50e-2)" "unprognostic (8.96e-2)" "unprognostic (1.11e-2)" "prognostic favorable (1.63e-4)" "unprognostic (6.11e-2)" "unprognostic (2.02e-1)" "unprognostic (1.17e-2)" "unprognostic (9.45e-2)" "unprognostic (1.01e-1)" "unprognostic (1.51e-2)" "unprognostic (1.35e-1)" 1.3 2.0 1.8 1.6 2.0 2.1 2.4 1.8 1.8 1.5 1.2 2.1 3.7 1.6 3.2 1.8 3.2 1.9 1.5 1.6 1.8 4.6 3.1 1.7 2.2 2.4 1.9 3.4 2.9 2.1 2.1 2.1 2.4 1.8 2.3 1.9 2.1 2.7 8.0 1.6 3.6 0.6 1.8 2.1 3.5 12.3 2.8 2.7 3.0 7.1 2.2 1.7 1.2 3.3 2.1 3.3 6.6 3.1 2.1 0.4 6.9 0.8 1.5 3.3 2.3 9.8 3.0 11.5 4.0 0.6 8.0 3.2 2.8 1.9 1.2 2.2 2.6 4.0 3.2 2.9 2.9 4.4 5.0 1.4 2.2 2.2 2.2 1.5 0.2 12.7 3.0 4.1 1.3 4.0 6.6 6.1 4.9 13.0 2.6 4.3 7.0 3.7 2.6 7.3 5.5 3.6 5.6 2.0 8.1 6.2 5.6 3.2 0.6 1.0 2.1 1.5 1.8 5.7 5.8 9.3 0.6 2.7 2.9 0.1 4.7 7.5 5.5 3.0 7.6 10.6 7.3 6.6 5.3 10.5 13.3 10.9 1.1 8.4 3.4 6.3 3.7 4.8 1.8 2.0 1.8 1.8 1.6 1.8 2.4 1.9 2.4 1.8 2.8 3.3 0.6 0.0 0.0 1.0 2.5 0.8 1.1 2.9 4.0 0.9 1.7 1.9 1.1 2.8 1.4 3.7 0.0 13.2 0.7 0.9 5.9 2.6 55.4 1.5 0.7 1.0 0.0 4.0 0.3 4.4 14.1 1.4 2.0 1.1 0.0 1.9 2.2 4.2 5.4 3.3 0.2 3.1 4.1 1.3 0.0 29.4 1.8 2.3 1.8 0.0 0.7 9.8 2.1 0.5 1.1 2.8 0.5 1.2 0.8 1.0 4.3 17.7 1.9 1.6 0.0 1.3 0.9 46.7 10.7 2.9 0.6 8.1 1.4 3.0 3.1 0.3 LMTK2 "AATYK2, BREK, cprk, KIAA1079, KPI-2, KPI2, LMR2, PPP1R100" ENSG00000164715 "Lemur tyrosine kinase 2" Q8IWU2 7 98106862-98209638 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal enterocytes: 50.7;Excitatory neurons: 114.9;Inhibitory neurons: 69.0;Oligodendrocyte precursor cells: 52.3" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "cerebral cortex: 25.2" "Immune cell enhanced" "Detected in single" "neutrophil: 1.4" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA010657, HPA041836" Uncertain Approved "Nuclear speckles,Plasma membrane,Centriolar satellite,Cytosol" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nuclear speckles, Centriolar satellite" "Plasma membrane, Cytosol" "HPA010657: AB_1079259, HPA041836: AB_2677698" "unprognostic (7.36e-2)" "unprognostic (3.16e-1)" "unprognostic (1.59e-1)" "unprognostic (2.60e-3)" "unprognostic (2.47e-2)" "unprognostic (2.45e-1)" "unprognostic (2.35e-2)" "unprognostic (1.23e-1)" "unprognostic (4.96e-1)" "prognostic unfavorable (8.03e-4)" "unprognostic (1.23e-1)" "unprognostic (4.65e-1)" "prognostic favorable (1.12e-7)" "unprognostic (1.88e-1)" "unprognostic (3.92e-1)" "unprognostic (2.16e-2)" "unprognostic (6.38e-3)" 3.5 7.0 4.2 3.9 6.2 13.8 3.6 0.0 25.2 4.9 0.0 9.7 8.8 3.9 3.9 9.5 4.1 4.2 12.4 6.0 0.0 6.6 6.2 6.6 3.6 2.1 0.5 5.0 14.8 10.7 7.0 3.1 1.8 5.1 8.0 8.2 7.9 4.0 11.1 9.0 9.8 3.7 0.0 4.6 6.5 5.2 1.2 4.9 5.8 7.0 4.8 5.8 6.2 8.7 12.5 14.5 11.0 11.4 5.8 4.6 10.2 5.1 5.5 4.9 5.9 11.5 11.1 6.5 14.3 6.5 18.6 13.4 12.8 7.8 7.6 9.4 9.0 4.4 13.0 11.6 7.0 8.0 7.6 3.2 10.5 10.1 13.6 4.9 7.4 7.4 11.8 13.4 4.5 16.9 8.5 4.8 13.4 17.1 7.0 9.2 7.5 13.0 8.2 21.7 7.8 15.7 10.2 18.4 7.4 11.0 5.1 3.2 9.2 10.2 16.6 20.5 11.7 5.9 11.2 12.8 6.8 6.2 12.3 0.5 0.1 0.1 0.2 0.0 0.1 0.1 0.2 0.2 0.1 0.2 0.3 0.4 1.4 0.1 0.3 0.2 0.2 0.1 4.2 6.2 0.0 25.2 6.0 0.0 2.1 0.5 1.8 0.0 1.2 8.7 6.0 28.9 17.0 28.7 7.8 9.7 4.3 6.2 14.8 14.2 5.5 3.9 22.4 15.7 11.8 1.8 14.6 2.8 7.5 50.7 1.9 6.1 1.1 13.2 7.6 5.7 12.0 8.4 114.9 9.1 1.9 5.4 21.4 26.4 2.5 5.3 2.5 8.4 2.2 6.7 69.0 14.7 4.1 1.6 2.3 2.0 1.8 3.2 1.8 16.9 2.8 6.1 7.2 52.3 29.6 10.3 23.8 4.5 12.9 8.8 14.0 3.0 15.8 10.6 0.0 8.6 5.7 6.9 6.3 15.5 10.9 3.0 8.6 2.7 14.7 20.5 LMTK3 "KIAA1883, LMR3, PPP1R101, TYKLM3" ENSG00000142235 "Lemur tyrosine kinase 3" Q96Q04 19 48485271-48513935 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 8 "brain: 44.0" "Cell type enhanced" "Detected in many" "Club cells: 41.4;Excitatory neurons: 37.0;Inhibitory neurons: 38.8;Urothelial cells: 49.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HMC-1: 9.4;SK-BR-3: 16.4;U-266/70: 9.8;U-266/84: 9.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040203, HPA077070" Enhanced Supported Uncertain "Nucleoplasm,Cell Junctions" NA NA "Cluster 20: T-cells - T-cell receptor" "Cluster 10: Brain - Neuronal signaling" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Nucleoplasm "Cell Junctions" "HPA040203: AB_10671690, HPA077070: AB_2732330" "unprognostic (2.41e-1)" "unprognostic (1.48e-1)" "unprognostic (5.37e-2)" "unprognostic (5.45e-2)" "unprognostic (2.95e-1)" "unprognostic (1.71e-2)" "unprognostic (5.67e-2)" "unprognostic (2.46e-1)" "unprognostic (2.09e-1)" "unprognostic (2.51e-3)" "unprognostic (5.71e-2)" "unprognostic (1.47e-1)" "prognostic favorable (3.18e-8)" "unprognostic (1.38e-1)" "unprognostic (3.22e-2)" "unprognostic (3.24e-1)" "unprognostic (6.11e-2)" 0.0 1.7 23.1 0.7 27.5 0.4 0.7 6.1 44.0 0.6 0.0 0.2 3.7 0.1 1.1 0.6 0.3 0.4 0.3 31.7 6.7 1.1 0.0 1.3 1.1 9.9 1.2 0.1 0.8 3.6 5.7 0.6 1.5 1.5 0.0 2.7 2.6 1.1 0.0 0.8 1.9 0.0 0.7 0.6 1.2 0.2 8.4 0.4 0.8 0.0 0.8 0.2 0.0 21.8 6.0 4.4 0.5 0.5 0.0 0.0 5.1 0.1 0.4 0.0 0.2 3.7 5.2 1.6 1.5 0.0 1.4 3.0 0.8 1.9 0.0 0.7 2.8 0.2 2.5 0.9 0.0 0.0 9.4 0.1 1.1 0.3 0.0 2.0 0.0 5.0 1.6 3.6 0.0 7.9 1.1 4.1 1.2 3.4 1.5 4.8 0.0 2.1 1.7 1.2 1.5 2.9 0.2 16.4 0.9 1.2 5.6 0.2 0.1 0.0 1.5 0.1 0.0 9.8 9.3 1.9 0.3 4.6 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.1 0.4 0.0 0.0 0.4 0.4 0.0 0.0 0.0 0.0 0.4 0.0 23.1 27.5 6.1 44.0 31.7 6.7 9.9 1.2 1.5 0.7 8.4 21.8 0.3 3.2 1.7 11.8 2.1 0.5 13.1 17.0 2.8 15.9 20.5 6.2 2.7 2.8 41.4 7.3 0.0 4.9 0.6 0.4 25.4 21.5 0.1 8.4 0.6 0.5 0.0 0.0 37.0 0.4 2.8 0.9 6.6 8.1 0.0 0.6 1.4 0.4 1.3 18.5 38.8 1.2 8.2 0.6 0.9 0.2 0.6 0.4 3.6 1.9 0.2 6.9 0.0 26.2 9.6 17.2 0.1 0.0 14.5 18.8 3.0 0.6 25.9 2.2 0.0 0.4 3.3 4.0 3.3 7.1 1.8 6.8 1.3 2.9 1.5 49.5 LNX1 "LNX, MPDZ, PDZRN2" ENSG00000072201 "Ligand of numb-protein X 1" Q8TBB1 4 53459301-53701405 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Adipocytes: 77.5;Early spermatids: 171.7;Excitatory neurons: 123.8;Glandular and luminal cells: 83.0" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in many" 9 "amygdala: 2.7;basal ganglia: 6.0;cerebral cortex: 10.3;hippocampal formation: 7.5;white matter: 3.1" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "OE19: 17.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002235, HPA071091" Approved Supported "Cell Junctions,Cytosol" "Intracellular and membrane" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 24: Salivary gland - Salivary secretion" "Cluster 21: OE19 - Mitochondria" "Cluster 44: Endometrium - Transcription" "Cell Junctions" Cytosol "HPA002235: AB_1079261, HPA071091: AB_2686344" "unprognostic (4.95e-2)" "unprognostic (1.74e-2)" "unprognostic (2.00e-2)" "unprognostic (3.16e-2)" "unprognostic (2.79e-1)" "unprognostic (2.31e-1)" "unprognostic (1.31e-1)" "unprognostic (5.62e-2)" "unprognostic (8.14e-2)" "unprognostic (1.06e-1)" "unprognostic (5.18e-2)" "unprognostic (8.56e-2)" "prognostic favorable (3.08e-7)" "unprognostic (2.67e-1)" "unprognostic (5.49e-2)" "unprognostic (6.81e-2)" "unprognostic (3.05e-2)" 21.9 2.5 2.7 2.1 6.0 1.0 14.3 0.1 10.3 6.1 0.0 6.7 9.4 4.2 0.6 24.4 6.4 5.5 8.7 7.5 0.1 10.6 4.4 2.7 2.1 0.0 0.1 2.1 16.3 11.9 4.3 24.6 0.4 5.9 6.9 3.8 25.1 7.2 5.9 11.8 9.0 3.0 0.0 0.9 9.5 4.4 0.6 3.3 17.9 12.0 4.1 4.3 7.9 3.1 1.4 0.5 1.6 0.9 2.7 5.8 8.0 1.2 0.6 0.0 0.0 2.9 8.9 1.7 1.1 4.3 0.4 1.4 0.0 0.2 0.0 0.4 4.6 2.2 1.5 1.5 1.3 2.4 0.7 4.4 0.2 0.3 0.0 1.9 2.7 0.8 1.9 0.8 6.4 4.5 2.2 1.7 4.3 17.7 0.7 1.2 0.6 0.7 5.6 8.2 2.2 2.1 0.6 10.8 0.9 9.1 5.7 1.1 7.8 10.0 2.6 3.1 1.6 3.6 0.5 1.1 8.7 2.0 1.5 0.3 0.0 0.0 0.1 0.1 0.2 0.2 0.2 0.2 0.1 0.1 0.2 0.2 0.0 0.7 0.4 0.2 0.2 0.0 2.7 6.0 0.1 10.3 7.5 0.1 0.0 0.1 0.4 0.0 0.6 3.1 77.5 0.0 3.9 4.9 1.7 8.2 18.0 14.5 24.5 7.5 13.3 7.1 1.6 12.8 15.5 7.3 6.2 30.6 1.5 18.5 19.6 13.7 171.7 37.7 7.6 16.0 13.8 3.6 123.8 11.7 22.1 4.8 14.3 83.0 2.5 1.5 2.9 6.2 2.5 42.1 42.2 13.4 14.2 0.3 2.1 47.9 4.4 1.3 5.4 11.2 0.4 2.2 2.1 43.7 4.0 12.3 26.5 8.6 0.9 8.5 14.5 2.9 17.9 5.8 0.0 10.0 2.2 0.9 2.6 32.2 11.9 14.9 1.9 1.4 14.2 15.2 LPCAT1 "AGPAT10, AGPAT9, AYTL2, FLJ12443" ENSG00000153395 "Lysophosphatidylcholine acyltransferase 1" Q8NF37 5 1456480-1523962 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lung: 57.3;lymphoid tissue: 38.2" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 324.0;Cone photoreceptor cells: 146.0;Rod photoreceptor cells: 148.2" "Cancer enhanced" "Detected in all" "lung cancer: 79.2" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "BEWO: 89.1;EFO-21: 82.4;PC-3: 60.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA012501, HPA022268" Enhanced Supported "Endoplasmic reticulum,Lipid droplets" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 64: Macrophages - Immune response" "Cluster 28: BEWO - Transcription regulation" "Cluster 11: Alveolar cells - Smell perception" "Endoplasmic reticulum" "Lipid droplets" "HPA012501: AB_1845224, HPA022268: AB_1845225" "unprognostic (5.33e-3)" "prognostic unfavorable (7.11e-5)" "unprognostic (3.11e-1)" "prognostic unfavorable (3.67e-4)" "unprognostic (3.13e-2)" "unprognostic (1.26e-2)" "prognostic unfavorable (1.88e-8)" "unprognostic (5.90e-2)" "unprognostic (6.37e-2)" "unprognostic (2.08e-2)" "prognostic favorable (4.90e-5)" "unprognostic (4.89e-2)" "prognostic unfavorable (2.64e-7)" "unprognostic (2.60e-1)" "unprognostic (3.13e-1)" "unprognostic (1.52e-1)" "unprognostic (4.03e-1)" 11.1 9.4 3.4 2.4 3.5 1.4 8.4 0.6 13.3 10.6 3.2 8.8 0.8 12.4 0.1 4.6 10.8 0.8 7.7 6.0 8.3 6.1 3.9 57.3 1.6 3.3 5.0 8.6 5.1 0.6 10.0 1.4 6.3 6.8 0.1 2.1 8.3 0.8 2.5 5.0 11.2 0.4 2.3 38.2 6.9 2.8 5.1 0.5 7.3 0.0 0.3 11.5 7.0 1.0 5.5 8.1 1.5 8.6 1.0 1.3 89.1 19.2 1.1 1.0 0.9 3.1 2.6 17.7 82.4 0.5 3.8 15.7 1.7 0.5 0.5 41.5 36.1 4.4 12.7 5.8 1.7 4.7 11.8 1.5 0.4 1.0 0.2 1.3 1.1 6.2 9.8 3.5 0.0 11.8 17.3 7.3 31.2 0.5 60.7 32.2 1.5 13.7 3.6 7.5 11.5 11.1 16.5 14.8 5.1 0.9 6.9 7.4 9.8 1.6 19.0 6.1 7.3 10.9 11.0 4.4 3.7 7.7 5.5 0.0 0.2 0.2 1.1 0.5 1.1 0.2 0.2 0.5 0.1 0.1 0.0 0.3 0.8 0.5 0.4 0.0 0.2 0.2 3.4 3.5 0.6 13.3 6.0 8.3 3.3 5.0 6.3 2.3 5.1 1.0 12.6 86.6 324.0 18.9 41.9 6.2 2.5 5.3 6.8 65.8 8.9 6.3 4.0 5.7 14.4 14.7 146.0 9.0 97.4 6.7 0.0 22.4 1.7 4.8 13.7 13.5 14.9 3.6 13.9 13.6 81.9 13.1 7.1 5.2 8.2 44.7 16.4 5.2 27.0 23.5 16.7 9.6 2.0 29.2 20.5 2.8 10.8 42.6 7.2 22.5 15.7 30.3 96.8 14.1 1.7 20.3 0.3 15.4 39.9 6.2 2.0 4.6 5.7 148.2 0.0 6.3 11.5 3.4 12.2 1.5 4.0 31.7 30.7 22.5 5.3 1.7 LPCAT2 "AGPAT11, AYTL1, FLJ20481, LysoPAFAT" ENSG00000087253 "Lysophosphatidylcholine acyltransferase 2" Q7L5N7 16 55509072-55586666 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 88.3;thyroid gland: 86.3" "Cell type enhanced" "Detected in many" "granulocytes: 173.3;Microglial cells: 224.9" "Cancer enhanced" "Detected in all" "thyroid cancer: 23.1" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 151.4;eosinophil: 199.2" "Lineage enriched" "Detected in many" 5 "granulocytes: 199.2" "Cell line enhanced" "Detected in many" "CAPAN-2: 115.9;HaCaT: 89.2;HL-60: 103.0;HMC-1: 161.7;hTERT-RPE1: 162.9;WM-115: 117.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007891, HPA008433" Enhanced Supported Supported "Endoplasmic reticulum,Lipid droplets" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 3: HMC-1 - Innate immune response" "Cluster 60: Granulocytes - Receptor signaling" "Endoplasmic reticulum" "Lipid droplets" "HPA007891: AB_1845223, HPA008433: " "unprognostic (1.43e-1)" "unprognostic (2.44e-2)" "prognostic favorable (3.43e-4)" "prognostic favorable (8.03e-6)" "unprognostic (2.91e-1)" "unprognostic (9.65e-3)" "unprognostic (8.12e-3)" "unprognostic (3.26e-3)" "unprognostic (1.67e-1)" "unprognostic (7.97e-2)" "unprognostic (3.18e-3)" "unprognostic (9.16e-2)" "unprognostic (1.93e-1)" "unprognostic (2.33e-1)" "unprognostic (4.15e-2)" "unprognostic (1.96e-1)" "unprognostic (3.53e-2)" 9.8 9.0 5.6 14.4 7.7 88.3 12.2 10.6 5.2 14.0 10.7 9.0 7.4 18.5 36.7 7.8 8.8 10.5 5.7 4.8 8.5 10.9 3.9 10.4 5.0 13.7 8.5 15.8 5.4 13.6 1.0 16.0 15.9 7.0 9.3 7.7 8.4 28.6 2.2 12.0 9.1 15.0 12.7 11.8 9.0 4.1 7.9 3.5 86.3 5.8 4.0 9.5 7.5 22.4 33.5 4.2 3.5 0.3 10.8 4.1 5.6 14.1 13.5 6.8 6.9 7.5 115.9 0.0 46.6 19.9 5.5 89.2 2.2 19.4 10.9 9.1 9.6 34.2 10.2 17.3 4.1 103.0 161.7 2.1 19.2 7.5 6.3 162.9 53.5 1.8 1.5 0.4 11.6 2.1 0.0 41.8 5.1 9.5 0.4 10.4 3.8 5.1 6.8 12.9 2.2 25.3 27.1 10.8 19.9 15.8 4.6 25.8 60.3 0.3 0.1 6.9 9.6 0.6 0.2 0.2 0.5 49.4 117.8 151.4 17.5 199.2 0.0 27.4 0.0 0.0 0.0 0.0 21.0 0.1 0.0 0.0 47.0 0.0 39.1 0.7 0.0 6.5 5.6 7.7 10.6 5.2 4.8 8.5 13.7 8.5 15.9 12.7 7.9 22.4 68.6 6.4 25.7 2.9 1.1 15.4 37.2 68.3 17.1 5.5 8.8 33.9 2.2 4.3 22.3 68.0 10.4 0.7 3.3 7.0 1.9 8.3 1.7 6.4 4.8 41.0 1.2 9.7 8.1 9.7 7.5 20.7 10.2 13.9 173.3 0.4 12.1 2.0 36.5 0.0 11.7 12.2 18.3 71.9 57.7 3.1 16.4 74.4 17.8 224.9 40.6 24.0 0.0 4.5 66.5 32.8 23.0 12.8 1.0 9.0 3.4 3.5 8.1 5.3 0.0 20.0 4.2 49.6 24.0 14.2 15.3 1.9 5.6 7.0 11.6 17.6 LPCAT3 "C3F, MBOAT5, nessy, OACT5" ENSG00000111684 "Lysophosphatidylcholine acyltransferase 3" Q6P1A2 12 6976185-7018477 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 103.5;Proximal enterocytes: 121.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RT4: 156.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 47: Cytotrophoblasts - Unknown function" "unprognostic (1.74e-1)" "unprognostic (3.33e-2)" "unprognostic (1.70e-1)" "unprognostic (1.57e-1)" "unprognostic (6.72e-2)" "unprognostic (3.86e-1)" "unprognostic (2.40e-2)" "unprognostic (6.90e-2)" "unprognostic (1.88e-1)" "unprognostic (5.00e-3)" "unprognostic (2.06e-1)" "unprognostic (2.58e-2)" "prognostic favorable (4.89e-5)" "unprognostic (1.13e-1)" "unprognostic (2.21e-1)" "unprognostic (6.49e-3)" "unprognostic (1.23e-1)" 36.6 52.1 8.4 21.6 9.3 28.4 36.3 11.1 9.5 20.3 10.3 51.4 123.0 18.8 21.5 32.0 21.2 18.6 37.4 8.3 9.0 44.4 109.2 46.0 17.0 11.0 9.7 17.7 50.8 19.6 15.2 38.0 9.2 35.9 47.9 4.0 37.3 16.3 45.6 34.0 99.7 21.7 9.2 20.1 58.7 11.2 9.9 21.5 27.7 57.5 21.2 35.3 21.7 9.3 20.2 34.0 15.8 44.3 109.4 51.2 32.9 11.8 49.5 31.7 53.4 78.6 103.9 21.9 6.5 19.1 65.7 50.8 19.2 43.0 24.3 52.7 21.3 44.7 28.2 71.5 23.6 23.3 45.8 81.2 24.7 30.2 15.1 20.1 30.0 33.0 24.4 15.4 20.9 30.0 29.1 28.7 53.1 73.1 20.2 29.9 21.5 22.4 38.7 156.0 13.6 12.5 68.5 107.3 7.9 49.5 10.9 31.4 12.0 19.2 27.8 34.1 8.3 19.1 14.5 30.9 24.0 23.5 17.0 44.4 55.7 91.0 21.5 80.5 25.4 12.3 22.3 24.8 37.2 12.3 20.1 21.3 53.7 32.3 98.7 21.1 29.7 38.3 8.4 9.3 11.1 9.5 8.3 9.0 11.0 9.7 9.2 9.2 9.9 9.3 17.9 70.5 38.5 15.7 13.1 23.6 39.4 35.8 36.5 5.2 19.8 13.8 0.6 12.8 30.3 20.2 0.0 103.5 11.6 47.0 11.7 29.9 2.5 18.8 21.4 13.1 43.2 57.7 20.7 33.0 51.7 14.3 49.5 26.6 14.0 10.6 15.0 62.9 41.6 11.8 16.7 26.8 26.4 21.9 9.6 1.7 18.3 15.2 7.2 6.5 15.8 12.2 15.5 25.6 22.4 18.1 27.1 6.4 17.5 24.7 121.9 37.2 16.4 4.0 19.7 6.0 18.2 24.3 35.3 17.7 22.3 66.4 18.9 17.0 41.2 25.9 LPCAT4 "AGPAT7, AYTL3, FLJ10257, LPAAT-eta, LPEAT2" ENSG00000176454 "Lysophosphatidylcholine acyltransferase 4" Q643R3 15 34358633-34367196 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 85.2;Gastric mucus-secreting cells: 131.5;Urothelial cells: 129.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HaCaT: 108.5;OE19: 113.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA057321 Supported NA NA "Cluster 13: T-cells - Unknown function" "Cluster 57: Non-specific - Angiogenesis" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "HPA057321: " "unprognostic (2.79e-2)" "unprognostic (8.34e-2)" "unprognostic (1.08e-2)" "unprognostic (4.64e-3)" "unprognostic (1.29e-2)" "unprognostic (2.15e-2)" "prognostic unfavorable (9.99e-4)" "unprognostic (7.47e-2)" "unprognostic (1.13e-1)" "unprognostic (2.90e-1)" "unprognostic (1.23e-3)" "unprognostic (1.33e-1)" "unprognostic (9.95e-3)" "unprognostic (1.52e-2)" "unprognostic (1.37e-1)" "unprognostic (1.69e-2)" "unprognostic (3.44e-3)" 19.7 6.2 18.0 12.2 18.3 6.7 17.8 12.8 38.5 21.6 4.0 44.8 30.9 14.4 9.4 36.1 18.7 17.0 26.0 18.8 21.2 9.3 3.4 10.0 9.7 26.2 12.8 11.8 10.2 7.1 11.8 5.1 26.0 11.1 35.9 4.9 11.8 8.8 8.3 18.6 31.2 16.7 8.5 16.3 39.7 3.3 18.1 8.7 8.4 8.0 11.2 22.2 28.9 21.6 13.7 31.9 15.7 12.6 41.4 41.9 7.5 18.8 31.5 17.6 24.0 11.6 36.0 12.4 38.4 26.3 41.3 108.5 13.8 35.5 7.8 25.2 8.2 12.5 13.6 11.3 8.5 13.5 12.3 31.3 15.8 16.6 21.4 40.6 29.0 22.1 8.3 23.6 33.1 13.3 11.9 26.1 15.7 113.7 26.0 14.7 17.6 25.1 38.7 32.4 12.6 9.5 11.3 14.9 7.3 18.2 11.5 17.9 36.4 32.5 19.6 51.8 18.3 28.5 23.9 4.3 24.3 37.0 7.6 0.1 0.8 3.6 2.7 1.1 6.6 1.6 3.2 4.2 1.3 2.3 1.8 1.7 3.5 1.7 1.4 4.6 5.6 0.8 18.0 18.3 12.8 38.5 18.8 21.2 26.2 12.8 26.0 8.5 18.1 21.6 31.0 25.6 5.9 8.8 13.1 4.8 7.8 35.5 15.4 15.5 5.8 8.3 12.8 25.8 63.1 9.2 4.2 4.9 15.7 85.2 1.9 11.6 0.0 7.1 7.8 31.9 25.3 9.2 57.5 9.8 17.1 9.6 131.5 10.1 12.0 5.5 23.6 0.7 7.9 10.1 53.3 58.0 24.4 8.1 9.7 1.2 15.5 6.3 8.8 9.4 5.7 1.7 9.2 12.5 7.2 43.1 83.4 6.8 29.1 9.7 58.7 2.8 40.7 5.9 13.1 5.1 11.9 2.5 8.1 20.3 6.1 2.5 19.9 8.6 71.8 129.9 LPGAT1 "FAM34A, FAM34A1, KIAA0205, NET8" ENSG00000123684 "Lysophosphatidylglycerol acyltransferase 1" Q92604 1 211743457-211830763 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 416.1;Oligodendrocytes: 474.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "eosinophil: 16.1" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 77: Retina - Visual perception" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 29: Early spermatids - Spermatogenesis" "unprognostic (4.60e-2)" "unprognostic (1.04e-1)" "unprognostic (3.90e-1)" "unprognostic (1.28e-1)" "unprognostic (1.36e-1)" "unprognostic (1.66e-1)" "unprognostic (9.47e-3)" "unprognostic (1.12e-2)" "unprognostic (1.08e-1)" "unprognostic (2.67e-1)" "unprognostic (2.54e-1)" "unprognostic (1.31e-1)" "unprognostic (1.64e-2)" "unprognostic (1.18e-1)" "unprognostic (2.02e-1)" "unprognostic (1.50e-2)" "unprognostic (3.70e-2)" 20.0 19.7 17.0 13.4 29.4 20.0 13.4 13.8 19.5 11.4 21.3 9.3 23.6 9.0 10.1 7.7 8.5 12.1 11.8 14.6 18.0 9.8 36.4 8.8 10.5 18.2 22.4 6.0 13.7 13.9 8.9 9.1 17.8 10.1 10.3 41.1 9.4 12.4 9.9 6.2 35.0 12.2 13.2 16.7 7.4 22.3 21.7 8.2 25.8 14.9 9.8 13.8 7.4 39.2 28.2 30.4 9.8 23.5 17.4 24.2 14.1 19.7 31.2 18.0 16.5 9.1 22.9 11.5 11.3 30.7 20.1 15.0 33.2 17.6 22.6 22.6 11.2 12.0 24.5 20.8 20.9 29.9 19.8 14.3 21.2 16.6 21.6 33.1 21.9 16.2 14.0 0.2 24.1 8.8 11.4 11.1 10.7 12.0 4.9 27.2 38.8 3.5 20.1 23.0 56.6 29.3 32.3 33.9 33.9 15.1 17.3 19.3 21.3 32.7 14.4 30.3 32.5 16.1 21.2 30.2 16.2 25.0 22.8 12.3 2.7 16.1 1.4 2.2 1.1 1.8 0.9 1.0 3.2 1.0 0.2 0.8 12.1 5.3 1.7 2.4 0.2 0.9 17.0 29.4 13.8 19.5 14.6 18.0 18.2 22.4 17.8 13.2 21.7 39.2 50.0 28.9 21.0 28.7 42.2 12.2 77.7 11.5 38.1 206.3 32.2 18.9 40.4 72.9 16.9 12.9 62.6 2.3 73.2 25.3 1.9 71.9 416.1 39.1 39.2 31.6 13.8 15.3 73.5 59.4 4.7 30.9 19.9 28.0 12.7 22.0 25.0 56.2 20.9 35.3 92.3 14.6 26.4 49.7 27.3 60.2 47.2 44.9 30.2 46.9 58.6 34.7 49.4 70.4 474.0 47.8 19.5 55.7 15.0 53.3 126.1 24.2 38.2 127.6 19.7 47.1 33.2 67.2 33.3 30.7 7.5 1.1 32.5 129.4 23.4 63.1 LRAT LCA14 ENSG00000121207 "Lecithin retinol acyltransferase" O95237 4 154626945-154753120 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Sensory transduction, Vision" "Acyltransferase, Transferase" "Disease variant, Leber congenital amaurosis" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 2.6" "Cell type enriched" "Detected in many" 6 "Granulosa cells: 104.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in some" "classical monocyte: 1.9" "Low lineage specificity" "Detected in many" "Cell line enriched" "Detected in some" 11 "NTERA-2: 15.3" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA070726 Uncertain "Endoplasmic reticulum,Golgi apparatus" NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 45: Intestine - Brush border" "Cluster 5: NTERA-2 - Transcription" "Cluster 40: Granulosa cells - Unknown function" "Golgi apparatus" "Endoplasmic reticulum" "HPA070726: " "unprognostic (3.64e-3)" "unprognostic (1.07e-2)" "unprognostic (1.05e-1)" "unprognostic (1.34e-1)" "unprognostic (4.75e-2)" "unprognostic (2.01e-1)" "unprognostic (3.38e-1)" "unprognostic (9.15e-2)" "unprognostic (2.48e-1)" "unprognostic (2.24e-1)" "unprognostic (2.65e-1)" "unprognostic (9.25e-2)" "unprognostic (1.03e-4)" "unprognostic (4.49e-6)" "unprognostic (6.11e-2)" "unprognostic (1.05e-1)" "unprognostic (3.98e-1)" 0.2 0.2 0.6 0.2 0.7 0.5 0.4 0.7 2.6 0.2 1.6 0.5 1.2 0.1 0.3 0.0 0.2 0.5 0.1 0.7 1.2 0.1 2.1 0.3 0.1 1.0 1.1 0.3 0.8 0.2 0.2 0.1 1.3 0.4 0.1 1.0 0.1 0.5 0.8 0.4 1.6 0.1 0.7 0.1 0.3 0.8 0.7 0.0 1.5 0.0 0.1 0.1 0.1 0.9 0.5 0.4 0.2 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.1 0.3 0.2 0.2 0.0 0.1 0.2 0.0 0.0 0.1 0.1 0.1 0.1 0.0 0.3 15.3 0.0 0.0 0.0 0.0 0.1 1.4 0.4 0.0 0.0 0.1 0.0 0.1 0.2 0.1 0.0 0.0 0.3 0.1 0.4 0.1 0.0 0.0 0.0 0.0 0.1 0.4 0.6 1.9 0.1 0.1 0.6 0.1 0.1 0.1 0.1 1.5 0.2 0.1 0.1 0.8 0.2 0.2 0.2 0.1 2.2 0.6 0.7 0.7 2.6 0.7 1.2 1.0 1.1 1.3 0.7 0.7 0.9 0.2 0.0 4.4 4.6 0.1 1.1 4.4 4.0 0.6 0.5 8.6 9.1 0.3 11.5 1.7 0.0 0.0 0.1 0.3 0.8 3.9 1.2 15.2 0.9 0.5 0.3 0.0 0.0 2.2 0.8 0.1 1.5 2.0 2.2 0.0 104.4 1.4 2.2 0.1 0.0 0.6 0.9 2.0 0.8 2.8 3.2 0.0 0.3 5.4 0.0 0.0 3.9 0.0 1.0 2.2 1.2 0.0 0.0 0.0 2.4 12.3 1.0 0.9 0.8 0.0 1.4 8.1 10.5 4.7 1.4 1.1 0.3 0.6 0.0 1.2 0.6 LRRK1 "FLJ23119, KIAA1790, RIPK6, Roco1" ENSG00000154237 "Leucine rich repeat kinase 1" Q38SD2 15 100919327-101078257 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 64.6;Microglial cells: 107.7" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in some" "cerebral cortex: 3.6" "Immune cell enhanced" "Detected in some" "plasmacytoid DC: 1.3" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "U-698: 27.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA010537 Uncertain Supported Mitochondria,Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 64: Macrophages - Immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol Mitochondria "HPA010537: AB_1079283" "unprognostic (3.74e-2)" "unprognostic (1.41e-1)" "unprognostic (2.82e-1)" "unprognostic (3.72e-1)" "unprognostic (6.68e-2)" "unprognostic (6.35e-2)" "unprognostic (1.94e-1)" "unprognostic (4.75e-2)" "unprognostic (3.43e-2)" "unprognostic (3.34e-2)" "unprognostic (2.95e-2)" "unprognostic (8.50e-2)" "prognostic unfavorable (5.71e-5)" "unprognostic (2.92e-2)" "unprognostic (1.82e-2)" "unprognostic (3.13e-1)" "unprognostic (5.25e-2)" 2.9 1.0 1.3 5.8 0.5 6.4 2.3 0.0 3.6 3.8 0.0 5.3 3.8 3.8 1.7 4.5 4.9 3.2 1.4 0.8 0.0 0.9 0.8 3.3 7.2 0.0 0.0 3.8 5.9 2.0 0.9 4.1 0.1 4.0 5.1 0.2 3.9 3.5 1.0 4.7 5.0 3.0 0.0 6.2 3.7 5.2 0.0 2.2 1.6 1.3 7.9 2.9 3.0 1.3 4.5 15.3 0.3 0.0 4.9 3.9 1.8 3.7 7.1 2.3 2.0 3.1 7.2 20.2 4.2 6.3 0.0 17.3 5.2 2.8 2.8 3.1 2.8 17.4 12.8 0.0 2.0 5.2 9.0 3.3 4.7 3.0 6.3 2.3 2.4 0.4 3.6 18.4 1.1 0.4 0.0 4.2 1.4 5.1 5.2 2.9 2.0 15.3 0.0 0.6 0.4 3.3 8.8 2.5 6.2 0.4 1.5 4.4 6.3 0.0 3.1 5.2 0.1 15.9 18.2 27.4 1.1 2.1 6.7 0.0 0.4 1.2 0.0 0.1 0.0 1.0 0.0 0.0 0.4 0.4 0.0 0.0 0.3 0.0 0.4 1.3 0.0 0.0 1.3 0.5 0.0 3.6 0.8 0.0 0.0 0.0 0.1 0.0 0.0 1.3 8.3 16.0 13.6 2.9 17.3 3.2 8.0 3.5 7.4 0.9 5.7 5.1 2.9 2.8 6.0 0.0 6.2 9.6 13.6 19.8 0.0 4.5 3.7 12.6 19.4 8.8 13.8 3.4 64.6 3.3 4.2 11.5 3.6 6.6 1.3 1.4 9.7 0.4 10.7 0.0 10.0 11.7 0.0 24.8 10.1 4.6 32.3 19.9 3.6 107.7 28.3 0.6 1.0 12.5 1.2 7.5 11.4 21.4 14.2 10.7 11.6 0.3 6.3 0.7 6.6 11.2 3.9 6.5 1.5 6.6 3.4 3.6 1.3 2.8 12.5 9.9 LRRK2 "DKFZp434H2111, FLJ45829, PARK8, RIPK7, ROCO2" ENSG00000188906 "Leucine rich repeat kinase 2" Q5S007 12 40196744-40369285 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Autophagy, Differentiation" "GTPase activation, Hydrolase, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "lung: 52.4" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 502.2;Excitatory neurons: 92.0;monocytes: 133.1;Oligodendrocyte precursor cells: 256.9" "Cancer enhanced" "Detected in many" "renal cancer: 17.1;thyroid cancer: 22.7" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in many" 8 "neutrophil: 58.2" "Lineage enriched" "Detected in many" 8 "granulocytes: 58.2" "Cell line enhanced" "Detected in some" "A549: 4.6;ASC TERT1: 5.6;BJ hTERT+: 3.2;RPTEC TERT1: 7.8;T-47d: 3.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA014293, CAB037160" Approved Supported Vesicles NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 11: Alveolar cells - Smell perception" Vesicles "CAB037160: AB_1840989, HPA014293: AB_1853353" "unprognostic (2.67e-1)" "unprognostic (1.75e-1)" "unprognostic (6.45e-3)" "unprognostic (1.06e-1)" "unprognostic (3.00e-2)" "unprognostic (6.10e-3)" "unprognostic (2.71e-1)" "unprognostic (3.14e-1)" "unprognostic (2.25e-1)" "unprognostic (9.07e-2)" "unprognostic (2.76e-1)" "unprognostic (1.23e-1)" "prognostic favorable (3.02e-6)" "unprognostic (2.55e-2)" "unprognostic (3.43e-2)" "unprognostic (2.01e-3)" "unprognostic (5.21e-3)" 4.8 3.1 1.1 10.1 1.9 9.0 2.6 0.9 2.1 5.1 1.2 4.3 0.6 4.8 1.9 7.0 4.1 6.2 3.9 1.3 1.1 10.9 5.6 52.4 6.8 1.7 1.1 5.4 3.6 8.4 2.1 1.2 1.4 2.6 1.8 1.5 3.5 2.0 5.5 2.1 3.6 4.0 1.1 10.8 2.1 0.8 1.2 2.5 2.9 7.9 5.4 4.5 5.5 1.9 0.0 4.6 0.0 0.0 2.3 5.6 0.0 1.3 3.2 0.1 0.1 0.0 0.0 0.0 0.0 0.8 0.1 0.0 0.0 0.0 0.2 0.0 0.3 0.2 0.1 0.0 0.6 0.4 0.0 2.1 0.4 0.0 0.0 2.5 0.4 0.0 0.0 0.0 0.4 0.0 0.0 0.8 0.1 0.0 0.0 0.0 0.0 0.0 7.8 0.0 0.0 0.3 0.0 0.5 2.7 0.1 3.1 1.5 1.0 0.4 0.5 0.6 0.4 0.0 0.0 0.0 1.3 0.0 1.7 0.0 7.2 2.2 0.0 5.2 0.0 1.8 0.0 0.0 2.1 1.7 0.0 0.0 58.2 0.0 6.9 0.3 0.0 1.3 1.1 1.9 0.9 2.1 1.3 1.1 1.7 1.1 1.4 1.1 1.2 1.9 7.4 32.1 502.2 17.3 29.9 2.4 1.8 0.4 2.8 8.6 1.3 1.4 7.8 5.7 17.3 27.6 0.0 0.0 1.9 0.0 1.9 1.3 0.5 0.4 2.6 7.0 0.0 2.1 92.0 2.7 0.1 16.1 0.5 0.4 13.9 2.7 13.2 8.2 4.6 47.1 28.0 0.0 0.0 55.8 8.7 1.2 19.0 52.2 12.4 73.1 133.1 8.6 3.1 256.9 3.1 0.8 1.1 12.0 2.8 0.6 0.0 22.5 3.4 1.0 0.0 22.5 4.8 0.3 1.0 12.6 3.1 0.4 3.4 11.2 0.0 0.7 LRSAM1 "CMT2P, FLJ31641, RIFLE, TAL" ENSG00000148356 "Leucine rich repeat and sterile alpha motif containing 1" Q6UWE0 9 127451489-127503499 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Autophagy, Protein transport, Transport, Ubl conjugation pathway" Transferase "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 32.0;Excitatory neurons: 28.6;Inhibitory neurons: 26.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021403, HPA021844, CAB037304" Supported Approved Cytosol NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 27: Brain & Skin - Unknown function" "Cluster 6: T47d - Mammary gland" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "CAB037304: AB_2138198, HPA021403: AB_1853366, HPA021844: AB_1853368" "unprognostic (8.83e-2)" "unprognostic (3.13e-1)" "unprognostic (7.48e-3)" "unprognostic (4.15e-3)" "unprognostic (9.42e-2)" "unprognostic (2.05e-1)" "unprognostic (1.64e-1)" "unprognostic (5.00e-2)" "unprognostic (1.66e-1)" "unprognostic (2.72e-2)" "prognostic favorable (6.78e-6)" "unprognostic (1.27e-1)" "prognostic favorable (5.72e-4)" "unprognostic (1.94e-2)" "unprognostic (3.26e-1)" "unprognostic (9.07e-2)" "unprognostic (3.33e-2)" 7.2 9.8 8.6 3.4 8.6 2.0 7.3 7.3 12.5 10.7 5.2 16.5 3.4 9.0 5.9 8.7 7.8 3.9 17.3 8.8 8.8 9.0 8.8 7.4 4.5 11.1 7.6 10.7 5.7 6.9 9.0 3.4 11.4 9.1 2.6 2.3 7.5 5.6 13.5 21.2 9.1 5.0 7.0 9.5 9.5 4.3 7.9 3.4 8.8 7.2 3.2 12.3 10.2 9.0 5.7 10.8 4.8 10.7 9.8 9.1 8.3 5.3 8.1 10.0 7.6 8.9 5.9 9.8 5.9 9.9 3.6 18.7 7.8 13.3 3.8 11.5 5.3 5.2 9.0 10.2 9.4 6.2 7.3 6.1 7.9 6.1 12.2 10.7 11.2 7.6 4.8 7.6 4.5 17.6 3.9 4.5 4.7 17.4 9.3 7.1 5.6 18.4 11.5 5.1 9.8 9.2 4.1 12.6 8.8 4.3 26.5 3.2 10.2 4.6 5.6 4.2 2.5 6.2 7.9 1.1 9.1 4.5 2.6 18.5 4.8 21.3 3.7 6.5 4.7 3.7 2.8 3.5 6.1 2.7 1.1 1.4 4.0 1.3 6.8 3.6 2.3 3.8 8.6 8.6 7.3 12.5 8.8 8.8 11.1 7.6 11.4 7.0 7.9 9.0 5.3 9.6 3.9 32.0 5.1 1.1 3.1 2.9 4.6 6.7 5.2 5.0 20.4 4.3 7.3 0.0 6.2 5.0 5.3 6.0 5.9 7.1 0.6 3.6 4.7 4.8 1.2 2.5 28.6 1.4 2.1 4.9 12.2 4.6 9.5 6.6 3.3 7.1 6.3 11.8 26.9 5.8 14.2 5.6 3.7 1.2 2.8 7.4 3.6 10.3 7.4 4.7 3.1 18.1 21.0 4.7 5.0 5.3 3.9 5.0 6.6 5.8 6.0 5.2 0.0 5.1 6.0 5.7 3.6 5.8 2.7 7.0 5.6 3.9 4.8 3.3 LTK TYK1 ENSG00000062524 "Leukocyte receptor tyrosine kinase" P29376 15 41503637-41513887 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Systemic lupus erythematosus" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 13.2;lung: 15.1;salivary gland: 11.8" "Cell type enhanced" "Detected in some" "Distal enterocytes: 25.3;Gastric mucus-secreting cells: 18.8;Hepatic stellate cells: 11.4;Intestinal goblet cells: 7.9;Proximal enterocytes: 15.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Group enriched" "Detected in some" 5 "MAIT T-cell: 5.7;plasmacytoid DC: 5.0" "Group enriched" "Detected in many" 10 "dendritic cells: 5.0;T-cells: 5.7" "Cell line enhanced" "Detected in some" "HEL: 5.0;NB-4: 9.7;RH-30: 4.6;THP-1: 14.7" "Low region specificity" "Detected in many" HPA059545 Approved Vesicles NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 43: THP-1 - Innate immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" Vesicles "HPA059545: AB_2684057" "unprognostic (9.47e-4)" "unprognostic (5.52e-4)" "unprognostic (1.51e-1)" "unprognostic (2.49e-1)" "unprognostic (4.12e-1)" "unprognostic (5.65e-3)" "unprognostic (1.74e-2)" "unprognostic (7.22e-2)" "unprognostic (2.89e-2)" "unprognostic (2.81e-3)" "unprognostic (9.36e-3)" "unprognostic (5.36e-2)" "unprognostic (4.68e-2)" "unprognostic (5.78e-2)" "unprognostic (1.52e-1)" "unprognostic (1.10e-1)" "unprognostic (1.90e-1)" 0.8 0.6 1.0 1.4 1.6 4.6 0.5 1.2 1.8 0.9 0.6 5.2 12.5 0.2 0.0 0.3 0.4 2.4 1.7 1.3 0.7 4.0 2.9 15.1 1.2 0.6 0.6 0.1 0.3 0.6 0.7 10.4 0.7 0.4 5.7 0.1 11.8 0.3 1.8 1.4 13.2 0.3 0.6 5.5 9.9 2.5 0.8 0.4 0.7 0.0 2.1 0.7 0.7 0.9 0.0 0.0 0.0 0.0 0.1 0.2 0.5 0.1 0.6 0.8 1.2 2.2 0.0 0.0 0.0 0.6 0.0 0.0 2.6 0.0 0.4 0.2 1.3 5.0 0.1 0.0 2.0 0.0 0.0 0.3 0.4 0.0 0.1 0.0 0.0 0.0 1.9 0.0 1.8 0.0 0.0 9.7 0.4 1.8 0.2 0.2 4.6 0.1 0.0 0.0 0.4 2.9 0.1 0.2 0.0 2.6 0.2 14.7 0.0 0.0 0.2 0.1 0.0 0.3 0.2 0.2 0.0 0.5 0.8 0.0 0.0 0.0 0.4 0.0 5.7 0.5 0.3 1.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 5.0 0.0 0.1 1.0 1.6 1.2 1.8 1.3 0.7 0.6 0.6 0.7 0.6 0.8 0.9 0.3 0.0 0.0 0.3 1.6 0.1 0.0 0.4 0.0 0.0 0.2 0.1 0.8 2.8 0.9 0.0 0.0 0.3 5.5 25.3 0.0 0.0 2.8 0.1 0.4 1.8 1.8 3.2 2.9 0.2 1.5 0.2 18.8 0.2 0.0 0.3 11.4 0.5 0.1 0.0 0.2 7.9 0.0 1.9 0.6 2.1 0.0 0.4 3.6 0.0 0.4 0.0 1.0 0.5 0.4 0.7 5.5 0.0 2.7 0.0 15.3 0.0 5.6 0.0 0.0 0.3 0.5 2.2 1.2 0.0 0.1 0.4 4.0 0.0 3.8 0.0 LTN1 "C21orf10, C21orf98, FLJ11053, KIAA0714, LISTERIN, RNF160, ZNF294" ENSG00000198862 "Listerin E3 ubiquitin protein ligase 1" O94822 21 28928144-28992956 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 213.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029143, CAB034164, HPA055604" Uncertain Enhanced Cytosol NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 29: Early spermatids - Spermatogenesis" Cytosol "CAB034164: AB_2180094, HPA029143: AB_10671360, HPA055604: AB_2682859" "unprognostic (3.67e-2)" "unprognostic (7.07e-2)" "unprognostic (7.78e-2)" "unprognostic (3.99e-1)" "unprognostic (1.42e-2)" "unprognostic (3.66e-3)" "unprognostic (5.38e-2)" "unprognostic (5.40e-2)" "unprognostic (9.98e-2)" "unprognostic (4.45e-2)" "unprognostic (2.85e-2)" "unprognostic (1.13e-1)" "unprognostic (9.87e-2)" "unprognostic (1.72e-1)" "unprognostic (8.22e-2)" "unprognostic (4.57e-2)" "unprognostic (1.52e-1)" 7.7 8.4 4.5 9.3 7.8 16.5 12.4 7.0 6.2 9.3 5.3 9.2 8.8 10.7 10.2 9.1 7.0 7.4 7.7 4.1 6.6 8.3 11.0 7.4 12.0 6.1 5.9 10.1 9.4 9.9 3.9 18.6 6.7 12.7 10.6 11.6 10.1 8.1 9.5 9.4 9.0 9.1 6.2 10.3 11.0 13.6 6.1 11.3 12.1 11.2 10.5 8.3 5.9 13.1 20.4 8.6 17.5 7.9 14.6 19.9 17.7 16.8 13.6 14.2 19.4 12.1 16.5 13.3 8.0 15.1 12.2 10.2 18.8 13.8 25.5 15.7 13.0 39.8 11.9 9.7 11.0 13.3 14.8 13.9 12.1 20.1 16.6 13.9 15.2 9.5 33.0 31.0 16.4 6.3 8.6 12.9 25.1 16.8 10.1 11.4 34.9 28.0 16.0 17.3 9.5 19.7 19.3 14.5 17.0 16.3 14.8 18.6 20.2 12.4 22.9 16.8 14.3 25.1 25.1 18.5 19.3 28.3 15.0 12.6 4.9 7.9 6.3 7.6 5.2 5.8 4.2 4.2 4.9 5.1 4.5 3.4 8.6 7.0 10.7 3.1 5.0 2.6 4.5 7.8 7.0 6.2 4.1 6.6 6.1 5.9 6.7 6.2 6.1 13.1 42.1 16.0 22.6 36.6 30.7 30.2 26.3 22.8 30.7 28.4 22.8 17.4 25.8 12.8 24.0 11.0 33.3 19.3 26.8 18.4 1.9 14.4 213.7 21.6 45.9 27.5 22.7 18.7 47.1 14.0 18.8 30.3 38.2 36.2 27.8 24.2 14.3 19.7 13.2 42.1 54.8 18.9 22.4 18.1 13.2 73.1 26.8 23.5 12.4 25.3 28.2 44.9 18.6 53.8 90.8 20.2 14.2 21.1 43.9 31.5 16.6 16.9 22.6 30.5 13.1 29.3 28.6 46.8 23.9 30.1 32.0 29.8 30.5 34.3 20.8 29.8 LYN JTK8 ENSG00000254087 "LYN proto-oncogene, Src family tyrosine kinase" P07948 8 55879835-56014169 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Adaptive immunity, Host-virus interaction, Immunity, Inflammatory response, Innate immunity" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 73.8;lymphoid tissue: 85.4" "Cell type enhanced" "Detected in many" "B-cells: 237.5;Kupffer cells: 183.7;Macrophages: 226.0;monocytes: 182.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 64.4" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HEL: 198.4;HMC-1: 193.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001231, CAB004492" Enhanced Supported "Golgi apparatus,Vesicles,Plasma membrane" NA NA 770000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 2: Immune cells - Immune response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 57: B-cells - Immune response" "Golgi apparatus, Plasma membrane" Vesicles "CAB004492: AB_627897, HPA001231: AB_1079286" "unprognostic (7.87e-2)" "unprognostic (4.89e-2)" "unprognostic (9.04e-2)" "unprognostic (3.74e-1)" "unprognostic (8.12e-2)" "unprognostic (2.17e-1)" "unprognostic (5.70e-2)" "unprognostic (1.11e-1)" "unprognostic (2.79e-1)" "unprognostic (8.80e-2)" "unprognostic (3.68e-2)" "unprognostic (7.15e-2)" "prognostic unfavorable (3.43e-4)" "unprognostic (2.13e-1)" "unprognostic (2.72e-3)" "unprognostic (1.21e-1)" "unprognostic (7.39e-2)" 17.2 7.3 3.9 79.2 4.0 73.8 9.2 7.4 8.7 11.0 7.8 14.2 36.3 6.2 4.8 8.6 10.0 23.5 5.4 4.4 5.5 5.9 14.9 28.2 49.2 9.4 7.2 3.6 9.5 6.3 4.8 23.5 8.3 5.6 13.3 8.9 17.0 9.7 1.6 3.7 31.6 14.2 7.2 85.4 13.3 3.1 9.0 10.4 10.6 4.4 53.1 29.7 5.7 11.2 47.2 24.6 6.9 0.7 0.5 0.0 43.6 34.6 54.7 21.0 15.7 18.0 15.5 41.2 15.0 12.1 15.3 19.3 22.2 23.8 14.6 70.0 19.8 198.4 6.9 5.5 4.0 20.6 193.4 0.8 7.8 0.6 13.6 13.1 27.2 0.0 98.3 90.2 3.0 3.3 0.1 21.5 38.6 72.9 2.1 3.3 9.6 5.0 9.8 24.9 4.5 74.8 17.3 0.1 7.5 44.9 3.4 41.4 33.1 0.0 10.0 0.1 15.0 26.4 13.2 102.4 1.5 38.8 1.7 4.5 12.2 22.7 1.6 28.3 1.3 15.9 0.3 0.6 10.3 16.1 0.2 0.7 64.4 4.3 49.1 16.2 0.0 5.0 3.9 4.0 7.4 8.7 4.4 5.5 9.4 7.2 8.3 7.2 9.0 11.2 21.0 35.3 37.5 27.7 237.5 5.4 23.8 32.4 4.6 6.3 10.3 7.0 2.2 18.6 44.5 9.2 2.1 2.9 130.0 14.5 0.0 21.8 0.9 14.6 26.2 28.1 6.0 40.4 1.1 53.0 65.2 13.6 18.8 15.9 72.8 0.5 22.9 13.2 126.6 0.0 2.5 14.1 14.2 183.7 96.1 2.4 3.4 226.0 5.4 92.8 182.6 54.3 94.7 13.0 1.7 40.7 13.3 1.2 58.9 62.9 26.0 2.1 40.9 2.6 19.7 3.7 6.4 1.2 2.1 4.9 5.8 38.7 25.0 62.5 17.1 82.4 MAEA "EMP, GID9, HLC-10, p44EMLP" ENSG00000090316 "Macrophage erythroblast attacher, E3 ubiquitin ligase" Q7L5Y9 4 1289887-1340147 "Enzymes, Predicted intracellular proteins" "Cell cycle, Cell division, Erythrocyte maturation, Ubl conjugation pathway" "Actin-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036886, HPA058185" Approved Enhanced Nucleoplasm Yes No "Cluster 5: Granulocytes - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 24: NB-4 - Immune response" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm "HPA036886: , HPA058185: AB_2683633" "unprognostic (2.70e-2)" "unprognostic (1.52e-1)" "unprognostic (1.78e-2)" "unprognostic (1.11e-1)" "unprognostic (2.03e-2)" "prognostic favorable (5.34e-4)" "unprognostic (3.10e-3)" "unprognostic (3.89e-2)" "unprognostic (1.78e-1)" "unprognostic (2.50e-1)" "unprognostic (6.94e-3)" "unprognostic (4.65e-3)" "prognostic favorable (1.90e-4)" "unprognostic (1.17e-2)" "unprognostic (2.49e-1)" "unprognostic (1.97e-1)" "unprognostic (4.51e-2)" 28.5 44.2 21.9 23.5 21.3 18.3 28.8 19.8 24.0 32.6 25.9 39.7 33.5 34.4 10.9 46.7 29.2 17.5 38.6 21.1 27.2 40.9 32.3 24.0 24.3 25.7 23.0 34.9 35.4 30.7 38.9 17.2 26.3 29.2 14.2 8.8 35.7 21.5 37.1 41.2 35.7 14.9 18.1 40.0 37.1 26.8 23.2 20.7 33.9 19.2 15.7 30.7 33.5 20.0 58.1 66.9 47.6 47.7 31.5 31.1 61.4 57.4 30.6 47.1 42.2 70.5 73.5 52.5 43.6 42.4 85.5 42.0 46.1 72.2 19.1 42.4 52.2 49.2 74.1 68.1 37.1 55.8 50.9 38.8 38.6 37.8 23.6 31.8 38.0 50.4 70.4 41.6 41.3 61.5 84.2 86.5 62.2 63.4 72.9 81.0 38.1 47.8 50.3 68.2 84.7 57.8 51.1 39.3 41.5 26.3 71.5 48.4 52.8 85.9 36.0 39.0 96.1 50.5 83.4 58.1 59.0 51.3 48.2 74.9 49.9 70.9 59.2 52.6 83.5 47.6 47.1 56.4 47.1 38.1 41.4 42.5 117.9 45.5 77.3 33.0 59.8 59.1 21.9 21.3 19.8 24.0 21.1 27.2 25.7 23.0 26.3 18.1 23.2 20.0 22.0 19.2 25.0 28.4 21.6 18.7 15.7 33.9 8.0 28.1 22.5 25.3 35.5 14.3 24.3 16.5 20.9 48.2 29.7 41.2 46.9 43.4 8.0 21.9 25.2 24.4 20.4 26.3 19.6 30.3 46.4 25.0 25.5 25.0 10.8 30.4 19.6 15.0 39.6 21.9 23.2 33.1 30.5 29.2 15.9 9.8 35.4 23.2 28.4 14.0 46.3 22.3 28.8 22.6 20.0 40.3 31.3 37.2 23.5 22.7 30.4 36.4 17.9 19.1 13.1 24.9 27.9 36.6 44.0 19.3 19.9 95.2 29.7 59.6 38.1 21.8 MAK "dJ417M14.2, RP62" ENSG00000111837 "Male germ cell associated kinase" P20794 6 10762723-10838553 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Differentiation, Spermatogenesis, Transcription, Transcription regulation" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 22 "retina: 118.9" "Group enriched" "Detected in many" 5 "Cone photoreceptor cells: 369.1;Early spermatids: 119.7;Rod photoreceptor cells: 330.1" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in single" "Immune cell enriched" "Detected in single" 9 "neutrophil: 6.3" "Lineage enriched" "Detected in single" 9 "granulocytes: 6.3" "Cell line enhanced" "Detected in single" "HDLM-2: 1.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 79: Retina - Phototransduction" "Cluster 44: HDLM-2 - Immune response" "Cluster 9: Photoreceptor cells - Phototransduction" "unprognostic (1.23e-3)" "unprognostic (8.77e-3)" "unprognostic (2.44e-1)" "unprognostic (3.81e-2)" "unprognostic (6.62e-2)" "unprognostic (1.35e-3)" "unprognostic (1.97e-2)" "unprognostic (2.53e-1)" "unprognostic (3.21e-2)" "unprognostic (2.42e-2)" "unprognostic (1.13e-3)" "unprognostic (6.73e-2)" "unprognostic (6.59e-5)" "unprognostic (1.55e-1)" "unprognostic (8.40e-2)" "unprognostic (7.71e-3)" "unprognostic (4.59e-2)" 0.3 0.1 0.2 0.6 0.0 0.6 0.4 1.5 0.4 0.3 5.4 0.0 0.1 0.4 0.0 0.2 5.4 0.4 0.1 0.1 0.0 0.2 0.0 0.7 0.1 0.7 0.9 0.1 0.2 4.6 0.8 0.1 0.1 0.2 0.0 118.9 0.2 0.0 0.1 0.3 0.1 0.0 0.2 0.7 0.3 4.7 0.2 0.0 0.2 0.0 0.1 0.1 0.1 0.4 0.7 0.0 0.3 0.2 0.0 0.0 0.4 0.0 0.0 0.2 0.3 0.0 0.4 0.1 0.1 0.0 0.4 0.1 0.1 0.0 0.1 1.3 0.4 0.0 0.0 0.0 0.0 0.5 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.0 0.1 0.4 0.2 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.5 0.2 0.0 0.1 0.0 0.2 0.2 0.1 0.0 0.1 0.2 0.0 0.2 0.2 0.0 0.1 0.0 0.1 0.1 0.4 0.6 0.3 0.3 0.3 0.3 0.1 0.3 0.2 0.3 0.4 0.3 0.5 6.3 0.2 0.6 0.3 0.1 0.1 0.2 0.0 1.5 0.4 0.1 0.0 0.7 0.9 0.1 0.2 0.2 0.4 2.1 0.0 6.4 16.3 1.5 0.4 2.3 0.8 2.8 14.6 4.0 3.9 0.9 0.0 5.3 3.7 369.1 0.5 0.5 0.1 0.0 0.4 119.7 43.3 1.7 1.8 0.0 1.3 45.6 0.2 1.0 2.2 1.1 3.8 2.5 0.3 1.1 0.1 0.2 5.0 39.4 0.0 2.0 0.6 0.7 47.1 0.6 1.3 1.8 12.2 1.3 23.6 0.0 30.7 21.5 0.1 0.0 0.4 1.0 1.1 0.0 0.1 48.9 330.1 0.0 5.4 1.5 15.2 5.5 0.7 0.4 0.8 0.8 0.3 0.0 0.8 MAP2K1 "MAPKK1, MEK1, PRKMK1" ENSG00000169032 "Mitogen-activated protein kinase kinase 1" Q02750 15 66386837-66491544 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Cardiomyopathy, Disease variant, Ectodermal dysplasia, FDA approved drug targets, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hepatocytes: 172.5;Langerhans cells: 265.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003834, HPA026430" Approved Enhanced "Plasma membrane,Cytosol" NA NA 120000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 39: Non-specific - Mitochondria" "Cluster 18: U-2197 - ECM organization" "Cluster 41: Macrophages - Immune response" "Plasma membrane, Cytosol" "CAB003834: AB_562310, HPA026430: AB_1853742" "unprognostic (4.05e-2)" "unprognostic (1.23e-2)" "unprognostic (2.07e-1)" "unprognostic (4.92e-2)" "prognostic unfavorable (1.95e-4)" "unprognostic (1.81e-3)" "unprognostic (5.78e-2)" "unprognostic (9.91e-3)" "unprognostic (1.11e-1)" "unprognostic (1.77e-1)" "unprognostic (1.45e-1)" "unprognostic (7.62e-3)" "unprognostic (1.20e-1)" "unprognostic (2.71e-1)" "unprognostic (1.96e-1)" "unprognostic (1.15e-1)" "unprognostic (9.40e-3)" 57.9 31.0 47.6 38.3 79.7 63.7 32.5 30.2 61.3 31.1 22.5 26.5 19.4 26.3 29.6 51.8 23.7 27.0 40.7 69.4 44.3 31.2 105.3 34.7 49.5 31.6 32.6 25.7 22.4 38.5 26.8 29.6 40.1 26.2 23.6 34.1 29.3 21.8 85.5 23.7 27.0 31.9 35.7 32.6 24.1 15.2 42.8 33.8 22.8 51.3 55.4 31.2 33.7 49.9 105.8 55.3 94.4 39.0 55.3 41.3 53.8 83.6 61.6 76.6 68.1 79.0 82.1 96.8 93.2 59.9 58.2 93.3 88.8 106.4 89.8 79.1 56.8 30.9 50.4 40.7 45.1 41.0 45.3 32.3 64.0 55.9 81.6 81.5 60.7 48.0 54.3 116.7 113.4 40.3 33.5 51.9 47.9 93.9 42.9 39.2 58.1 84.7 74.8 48.5 58.3 31.7 60.8 45.5 63.0 74.9 41.0 33.7 90.8 99.5 63.8 71.1 112.4 74.0 143.1 60.6 105.1 69.9 48.4 3.0 7.5 5.4 6.4 7.7 5.8 2.8 5.6 6.1 7.7 4.6 6.9 4.2 3.5 8.3 7.7 15.1 4.6 2.8 47.6 79.7 30.2 61.3 69.4 44.3 31.6 32.6 40.1 35.7 42.8 49.9 24.5 28.9 24.8 24.2 40.0 82.8 45.9 32.3 21.1 10.0 22.2 10.2 21.5 40.0 24.9 25.8 14.6 48.1 45.0 25.1 46.9 69.4 12.1 16.3 13.9 34.6 21.7 19.0 69.7 23.1 48.8 30.3 17.9 35.4 8.9 19.8 18.9 172.5 51.4 10.1 46.4 15.4 20.3 90.7 265.3 23.6 22.4 115.1 53.4 48.7 87.9 34.9 35.0 28.1 31.7 103.9 23.5 21.8 49.1 87.7 22.2 35.9 17.7 7.8 6.6 16.3 52.4 35.6 42.7 30.3 67.3 51.7 54.0 5.9 19.1 65.4 MAP2K2 "MEK2, PRKMK2" ENSG00000126934 "Mitogen-activated protein kinase kinase 2" P36507 19 4090321-4124122 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Cardiomyopathy, Disease variant, Ectodermal dysplasia, FDA approved drug targets, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 724.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003835, HPA051993" Supported Supported Cytosol NA NA 140000 "Cluster 52: Eosinophils - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 25: Spermatids - Spermatogenesis" Cytosol "CAB003835: AB_562312, HPA051993: AB_2681685" "unprognostic (4.39e-1)" "prognostic favorable (3.72e-4)" "unprognostic (4.24e-1)" "unprognostic (1.26e-3)" "unprognostic (2.58e-1)" "prognostic favorable (7.98e-4)" "unprognostic (2.08e-3)" "unprognostic (2.11e-1)" "unprognostic (2.65e-1)" "unprognostic (1.06e-1)" "unprognostic (7.45e-3)" "unprognostic (4.95e-2)" "unprognostic (1.32e-1)" "prognostic favorable (5.43e-5)" "unprognostic (2.91e-2)" "unprognostic (2.25e-1)" "unprognostic (4.90e-2)" 73.9 118.4 145.5 54.1 143.1 102.4 69.1 151.5 190.7 76.6 150.4 103.4 134.0 72.3 23.2 121.6 64.7 30.4 156.6 145.9 147.3 82.6 123.3 66.8 57.1 149.6 152.9 84.1 134.3 54.9 99.3 36.4 154.3 93.9 42.7 68.0 79.6 37.6 289.0 95.8 101.0 31.7 143.5 89.1 92.7 131.6 150.7 69.3 74.6 132.1 41.0 77.2 75.2 142.8 163.1 175.4 93.7 132.8 127.1 151.9 93.8 104.5 138.8 139.6 125.8 153.0 85.5 137.7 95.9 120.0 111.9 114.3 74.2 111.6 107.4 118.1 90.4 50.5 91.4 171.7 194.0 93.6 101.8 168.8 106.8 98.2 129.5 185.5 125.2 123.0 98.1 263.1 119.3 203.5 186.3 130.6 107.8 118.6 125.9 140.7 61.9 159.1 123.5 102.7 126.8 126.3 95.7 130.6 344.1 107.3 101.0 158.5 111.8 113.6 98.2 293.4 163.9 263.1 172.4 100.2 176.5 166.8 199.3 27.5 13.0 45.4 16.9 16.6 13.6 13.0 13.3 17.2 15.9 18.2 12.3 15.9 21.2 18.8 14.1 9.0 14.3 7.3 145.5 143.1 151.5 190.7 145.9 147.3 149.6 152.9 154.3 143.5 150.7 142.8 77.7 9.6 31.9 22.5 62.3 35.4 93.3 21.3 15.4 85.1 92.9 95.4 62.9 44.3 22.8 40.5 41.7 28.7 102.3 300.5 146.8 20.7 248.1 59.5 68.3 52.1 63.2 123.1 17.6 45.5 38.6 60.3 64.7 48.8 19.7 124.4 49.2 48.1 55.0 121.1 23.2 107.7 16.2 56.0 38.2 724.3 35.8 65.6 42.7 10.3 28.5 121.1 62.8 13.0 24.2 47.0 151.8 23.0 79.9 103.2 166.1 92.8 18.9 106.8 26.3 93.1 71.8 23.5 17.4 42.9 63.9 35.6 77.0 120.2 119.9 113.1 MAP2K3 "MAPKK3, MEK3, MKK3, PRKMK3" ENSG00000034152 "Mitogen-activated protein kinase kinase 3" P46734 17 21284672-21315232 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 212.4" "Cell type enhanced" "Detected in many" "Erythroid cells: 325.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB018548 Approved Supported Nucleoplasm,Cytosol NA NA 28000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 44: Endometrium - Transcription" "Nucleoplasm, Cytosol" "CAB018548: AB_631927" "unprognostic (2.31e-1)" "unprognostic (6.39e-2)" "unprognostic (4.63e-2)" "unprognostic (3.68e-1)" "unprognostic (3.54e-3)" "unprognostic (1.60e-1)" "unprognostic (2.97e-2)" "unprognostic (1.35e-2)" "unprognostic (5.25e-3)" "unprognostic (1.88e-2)" "unprognostic (3.16e-2)" "unprognostic (2.18e-2)" "unprognostic (1.33e-1)" "unprognostic (6.48e-2)" "unprognostic (1.22e-2)" "unprognostic (2.92e-1)" "unprognostic (1.77e-1)" 47.3 32.5 12.9 35.3 12.1 212.4 30.7 17.6 23.2 22.7 22.6 33.1 49.0 17.1 14.5 62.7 29.9 40.0 66.7 11.5 14.4 45.7 95.7 67.5 34.0 13.6 14.3 12.6 33.6 17.9 37.1 28.9 14.2 28.9 24.1 6.0 45.3 16.5 132.7 53.1 41.0 22.5 14.3 60.4 42.8 6.2 15.8 20.9 24.0 74.6 41.1 54.1 33.4 17.0 75.5 73.9 9.7 44.5 57.7 36.6 36.3 113.0 121.8 88.3 80.5 82.9 46.6 68.1 44.7 178.3 74.2 72.4 31.0 100.5 62.1 69.5 56.9 39.2 42.0 76.1 18.2 51.9 76.7 28.5 28.2 120.6 35.9 27.7 40.0 38.6 7.7 33.2 74.7 74.1 25.5 49.3 28.1 134.1 42.3 53.0 62.2 50.0 50.5 77.4 26.3 9.4 41.7 45.9 82.0 95.7 22.5 17.7 36.8 83.0 68.4 90.1 73.9 39.8 21.8 88.1 80.2 44.3 44.1 54.1 49.3 77.8 35.9 72.1 31.1 33.3 29.1 33.6 49.6 25.5 17.9 24.1 145.6 15.3 104.7 35.4 44.5 35.6 12.9 12.1 17.6 23.2 11.5 14.4 13.6 14.3 14.2 14.3 15.8 17.0 44.2 38.5 53.6 2.6 51.5 258.0 188.4 57.0 97.9 7.1 69.3 51.3 21.9 44.3 50.5 22.0 4.2 73.3 117.4 109.1 74.3 99.1 1.5 130.5 44.8 49.4 120.4 325.0 7.2 79.8 82.0 43.7 68.3 237.8 94.0 11.5 22.1 73.1 49.0 18.5 8.0 77.0 28.5 59.4 278.7 1.8 12.2 118.1 87.2 4.7 48.3 17.3 35.0 5.5 2.0 129.1 135.3 16.6 85.2 158.7 60.8 44.2 40.4 7.4 0.0 61.9 42.4 1.1 5.3 97.3 218.1 67.0 62.6 10.5 58.5 255.7 MAP2K4 "JNKK1, MEK4, MKK4, PRKMK4, SERK1" ENSG00000065559 "Mitogen-activated protein kinase kinase 4" P45985 17 12020829-12143830 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 226.9;Inhibitory neurons: 189.3;Oligodendrocyte precursor cells: 148.3;Oligodendrocytes: 203.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 10.4" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in all" 5 "SuSa: 177.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007751, HPA060074" Enhanced Approved "Nucleoplasm,Cell Junctions" NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 47: Non-specific - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "Cell Junctions" "CAB007751: , HPA060074: AB_2684197" "unprognostic (1.55e-1)" "unprognostic (1.85e-1)" "unprognostic (4.47e-2)" "unprognostic (1.02e-2)" "unprognostic (1.04e-1)" "unprognostic (2.70e-1)" "unprognostic (2.89e-1)" "unprognostic (2.16e-1)" "unprognostic (1.93e-3)" "unprognostic (2.53e-1)" "unprognostic (2.76e-3)" "unprognostic (4.82e-2)" "unprognostic (5.32e-3)" "unprognostic (3.13e-1)" "unprognostic (2.30e-1)" "unprognostic (7.00e-2)" "unprognostic (1.79e-1)" 11.4 13.1 27.3 10.1 30.2 3.6 14.5 18.7 44.8 12.0 8.7 12.0 10.1 12.1 17.5 18.8 11.4 10.9 15.8 32.7 28.5 16.2 21.8 11.7 11.7 30.0 21.8 12.6 11.5 19.4 13.8 15.8 30.9 14.3 13.1 15.4 10.5 12.7 24.1 15.1 10.5 13.8 19.0 11.6 11.2 11.0 25.9 15.2 16.7 28.2 14.4 14.7 13.0 30.1 31.1 26.2 33.8 17.5 18.3 23.5 21.3 20.6 27.1 23.1 21.9 15.6 10.4 12.8 16.4 32.4 15.2 20.2 29.7 28.8 34.3 22.7 33.7 14.2 14.1 29.8 21.4 13.7 20.5 19.6 27.9 27.0 28.0 23.9 21.3 17.8 15.4 7.3 29.4 11.5 16.8 12.9 19.6 33.2 12.4 20.3 37.8 8.9 31.6 19.7 6.8 19.9 23.8 12.7 20.3 177.7 16.1 10.0 19.6 11.3 17.4 15.8 24.9 14.2 16.9 9.9 21.3 10.7 16.8 0.4 2.1 1.7 2.2 1.2 1.9 2.1 1.8 1.8 1.5 2.7 1.5 2.4 10.4 2.7 3.9 1.5 2.2 1.8 27.3 30.2 18.7 44.8 32.7 28.5 30.0 21.8 30.9 19.0 25.9 30.1 13.9 9.6 19.4 71.8 27.1 41.4 36.1 12.7 66.0 15.3 20.4 16.3 22.6 7.2 18.3 14.7 8.4 12.6 17.7 19.1 25.4 12.3 7.2 16.9 16.4 12.0 12.0 14.5 226.9 14.3 10.3 19.4 42.3 27.3 1.3 20.1 11.0 20.8 11.7 18.5 189.3 13.1 20.3 19.9 14.7 8.9 11.8 15.4 12.4 68.4 24.1 11.3 14.4 148.3 203.0 16.9 9.3 12.8 26.9 37.7 11.0 25.2 8.6 10.0 13.1 19.2 20.2 7.3 9.3 56.7 39.2 25.3 20.7 15.0 13.3 41.5 MAP2K5 "HsT17454, MAPKK5, MEK5, PRKMK5" ENSG00000137764 "Mitogen-activated protein kinase kinase 5" Q13163 15 67542703-67807117 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 8 "Astrocytes: 119.5;Early spermatids: 138.1;Excitatory neurons: 201.4;Inhibitory neurons: 169.3;Late spermatids: 212.4;Microglial cells: 87.1;Oligodendrocyte precursor cells: 146.3;Oligodendrocytes: 146.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB022094, HPA027347, HPA027755" Supported Approved Nucleoli,Microtubules NA NA "Cluster 15: NK-cells - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoli, Microtubules" "CAB022094: , HPA027347: AB_10599290, HPA027755: AB_10600883" "unprognostic (4.54e-2)" "unprognostic (1.87e-2)" "unprognostic (4.16e-2)" "unprognostic (9.06e-2)" "unprognostic (1.77e-3)" "unprognostic (1.06e-1)" "unprognostic (1.96e-1)" "unprognostic (3.73e-1)" "unprognostic (2.41e-2)" "unprognostic (2.83e-1)" "unprognostic (1.47e-2)" "unprognostic (5.41e-2)" "prognostic favorable (8.03e-5)" "unprognostic (1.68e-1)" "unprognostic (2.74e-1)" "unprognostic (3.99e-2)" "unprognostic (2.73e-2)" 14.3 14.8 9.2 6.3 9.8 10.3 12.4 11.2 14.1 13.2 4.6 15.7 9.2 11.5 6.1 8.7 12.1 8.8 15.0 11.6 9.9 9.9 10.0 9.7 8.5 9.6 6.5 17.2 13.2 18.8 10.2 11.1 9.4 9.4 8.8 11.2 10.5 10.6 23.2 14.5 10.1 8.9 5.6 9.0 11.6 13.8 7.3 17.2 10.6 17.8 7.6 11.8 11.1 12.3 9.0 23.4 13.8 16.3 20.0 34.9 10.9 8.8 17.8 16.3 17.7 9.4 15.8 14.8 18.2 14.8 17.7 13.3 23.8 14.3 13.4 21.6 23.7 20.2 17.0 10.3 25.1 12.3 12.1 23.9 18.3 11.8 26.6 35.7 21.7 33.6 18.0 24.1 13.6 11.6 20.1 14.7 19.4 10.4 11.3 19.7 16.0 24.9 9.8 16.3 8.6 13.4 9.9 14.5 36.5 23.6 18.2 23.7 18.2 16.7 10.9 11.7 12.1 33.7 43.4 17.5 22.4 27.6 12.3 10.9 5.8 5.6 5.6 4.4 8.3 4.8 5.3 6.7 8.1 4.3 7.3 7.0 1.4 9.4 5.4 3.0 6.2 4.4 9.2 9.8 11.2 14.1 11.6 9.9 9.6 6.5 9.4 5.6 7.3 12.3 7.9 6.4 5.8 119.5 10.0 6.9 8.1 3.7 8.6 12.6 8.6 6.1 8.1 5.7 3.2 5.5 10.4 13.4 10.2 13.2 7.9 9.3 138.1 4.4 5.0 7.6 9.5 9.4 201.4 8.5 10.7 9.7 7.7 3.9 2.5 12.3 12.5 8.7 10.0 5.0 169.3 9.2 4.1 10.1 6.1 212.4 12.5 7.9 10.6 87.1 7.2 17.9 11.3 146.3 146.5 7.5 12.5 11.7 5.6 5.3 12.2 9.7 4.0 8.2 0.0 7.9 6.3 11.9 13.0 9.9 8.2 9.9 10.4 11.6 10.4 4.6 MAP2K6 "MAPKK6, MEK6, MKK6, PRKMK6, SAPKK3" ENSG00000108984 "Mitogen-activated protein kinase kinase 6" P52564 17 69414697-69553865 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Stress response, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 40.5" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 53.9;Glandular and luminal cells: 82.7;Oligodendrocytes: 52.5" "Cancer enhanced" "Detected in many" "endometrial cancer: 8.1" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 7 "classical monocyte: 22.0;neutrophil: 45.9;plasmacytoid DC: 78.3" "Group enriched" "Detected in all" 9 "dendritic cells: 78.3;granulocytes: 45.9;monocytes: 22.0" "Cell line enhanced" "Detected in many" "A549: 40.0;AN3-CA: 21.4;HUVEC TERT2: 28.4;MOLT-4: 21.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007744, HPA031134" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 44: Endometrium - Transcription" "Nucleoplasm, Cytosol" "CAB007744: AB_562318, HPA031134: AB_10603016" "prognostic favorable (2.27e-6)" "unprognostic (2.24e-1)" "unprognostic (8.46e-2)" "unprognostic (4.10e-2)" "unprognostic (3.75e-2)" "unprognostic (1.23e-1)" "unprognostic (7.61e-3)" "unprognostic (9.52e-2)" "unprognostic (3.67e-1)" "unprognostic (4.09e-3)" "prognostic favorable (7.52e-4)" "unprognostic (3.61e-2)" "unprognostic (2.29e-2)" "unprognostic (7.48e-2)" "unprognostic (9.43e-2)" "unprognostic (1.39e-1)" "unprognostic (2.03e-2)" 5.2 1.3 4.2 8.4 4.0 15.9 20.4 11.6 4.0 27.0 7.6 30.7 10.3 6.1 3.2 3.1 4.5 7.2 1.4 2.7 6.2 5.5 12.2 1.8 8.0 5.4 3.8 3.1 8.3 0.3 1.6 1.6 3.9 3.3 31.7 5.8 2.5 3.1 40.5 2.0 10.8 3.3 4.4 4.0 7.4 1.3 5.7 11.5 3.3 21.1 5.9 3.3 1.2 7.7 0.1 40.0 17.6 21.4 7.4 4.0 2.5 0.3 5.8 1.6 2.4 1.2 1.7 1.1 14.2 0.8 1.3 1.9 6.1 0.8 0.5 1.3 3.2 0.1 10.3 11.4 7.4 1.7 1.3 19.0 0.5 0.3 0.0 1.4 28.4 5.3 0.1 2.5 0.0 0.3 21.6 0.7 12.5 0.9 7.3 7.7 1.8 0.5 7.8 5.4 7.8 11.8 1.7 1.3 3.9 9.3 5.4 2.3 5.1 1.9 2.3 1.6 0.5 1.7 2.2 0.5 1.6 2.5 1.5 2.5 22.0 4.0 2.8 2.6 5.0 4.1 3.1 3.5 7.1 5.2 3.6 3.4 45.9 4.7 1.1 78.3 5.0 6.2 4.2 4.0 11.6 4.0 2.7 6.2 5.4 3.8 3.9 4.4 5.7 7.7 11.2 3.2 6.7 27.7 7.7 2.7 4.1 0.8 8.6 5.2 14.3 29.1 1.3 5.7 3.6 0.0 2.1 9.7 29.2 42.3 23.5 1.9 10.2 53.9 11.5 7.9 45.6 5.0 26.0 4.1 6.6 5.0 9.2 82.7 1.3 13.4 4.2 2.5 6.2 3.3 22.4 22.9 0.0 6.8 7.4 2.9 4.4 6.9 3.6 24.4 9.6 31.8 10.3 32.6 52.5 1.1 16.7 3.8 10.7 1.3 14.5 1.5 4.2 4.2 0.0 3.9 5.7 0.1 1.8 4.8 4.3 0.8 13.3 1.4 30.6 2.8 MAP2K7 "Jnkk2, MKK7, PRKMK7" ENSG00000076984 "Mitogen-activated protein kinase kinase 7" O14733 19 7903843-7914478 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001633, CAB004262, HPA064711" Supported Approved "Golgi apparatus,Plasma membrane,Cytosol" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 59: Non-specific - Translation" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 52: Non-specific - Transcription" "Plasma membrane, Cytosol" "Golgi apparatus" "CAB004262: AB_627925, HPA001633: AB_1079516, HPA064711: AB_2685331" "unprognostic (1.77e-1)" "unprognostic (5.04e-2)" "unprognostic (1.06e-2)" "unprognostic (2.16e-1)" "unprognostic (4.24e-2)" "prognostic favorable (8.54e-5)" "unprognostic (1.80e-3)" "unprognostic (2.55e-1)" "unprognostic (2.69e-2)" "unprognostic (1.69e-2)" "unprognostic (1.27e-3)" "unprognostic (1.56e-1)" "unprognostic (3.54e-2)" "unprognostic (3.71e-2)" "unprognostic (6.05e-2)" "unprognostic (1.73e-2)" "prognostic favorable (1.56e-4)" 19.1 17.0 17.9 11.7 17.8 19.4 19.5 16.8 19.0 25.1 10.4 24.4 13.1 26.1 3.7 20.2 20.5 5.9 20.8 14.8 15.2 18.7 24.7 17.1 11.7 17.3 17.3 23.2 21.6 9.6 23.4 9.2 17.1 21.0 4.6 5.6 19.2 7.9 52.4 27.9 20.1 6.2 15.1 24.5 18.8 17.5 17.3 10.9 19.0 16.4 6.1 22.0 22.4 19.9 25.8 14.4 12.2 20.2 9.7 9.3 22.8 16.5 8.0 11.0 11.3 20.9 15.2 30.5 25.9 8.8 10.7 22.9 10.7 12.8 4.3 24.7 53.3 21.4 20.9 15.6 12.4 20.1 26.0 10.8 16.1 8.7 9.8 14.5 10.0 21.9 31.9 38.5 6.5 13.4 28.8 48.6 21.7 13.6 32.0 28.5 13.4 31.0 9.8 21.0 22.4 22.5 11.3 19.4 23.9 7.3 21.0 22.7 15.3 33.2 19.0 23.7 22.7 55.5 27.7 28.8 16.6 29.2 13.6 0.0 0.8 0.6 0.6 0.8 0.4 0.7 0.5 0.6 0.4 1.0 0.5 0.7 1.5 1.0 0.5 0.8 0.2 0.4 17.9 17.8 16.8 19.0 14.8 15.2 17.3 17.3 17.1 15.1 17.3 19.9 15.4 25.6 18.1 11.1 27.0 38.6 37.2 22.7 22.2 52.9 23.5 16.5 14.4 24.3 14.5 20.2 77.2 28.3 27.8 31.1 13.7 22.8 4.8 16.2 20.3 19.5 36.5 23.6 9.9 19.0 31.1 18.5 16.3 24.8 10.8 33.3 21.4 22.2 18.6 57.2 11.0 24.0 32.6 22.2 17.1 11.7 28.9 20.5 32.0 6.5 25.3 23.9 46.4 9.0 15.0 25.7 20.8 12.4 30.4 39.8 38.7 18.4 15.3 65.7 32.9 30.2 22.1 17.7 36.4 22.7 42.6 49.3 30.3 30.3 27.6 33.2 MAP3K1 "MAPKKK1, MEKK, MEKK1" ENSG00000095015 "Mitogen-activated protein kinase kinase kinase 1" Q13233 5 56815549-56896152 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocyte precursor cells: 210.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "SH-SY5Y: 52.5;THP-1: 51.0" "Region enriched" "Detected in all" 6 "olfactory bulb: 18.2" "Low region specificity" "Detected in all" "CAB004500, HPA046509" Approved Approved Cytosol NA NA "Cluster 38: Basophils - Unknown function" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 57: B-cells - Immune response" Cytosol "CAB004500: AB_627926, HPA046509: AB_2679678" "unprognostic (1.77e-1)" "unprognostic (1.71e-2)" "unprognostic (4.09e-1)" "unprognostic (2.18e-1)" "unprognostic (3.48e-2)" "unprognostic (5.39e-3)" "unprognostic (5.20e-3)" "unprognostic (2.52e-2)" "unprognostic (1.35e-1)" "unprognostic (1.41e-1)" "unprognostic (1.05e-2)" "unprognostic (6.73e-2)" "unprognostic (1.97e-3)" "unprognostic (2.18e-2)" "unprognostic (1.58e-1)" "unprognostic (9.92e-3)" "unprognostic (1.11e-1)" 5.5 3.8 3.0 13.3 2.6 24.0 20.1 4.0 2.1 7.0 6.2 5.4 6.3 7.5 6.6 10.0 9.7 5.7 3.7 2.1 2.7 9.9 6.0 7.5 18.1 3.9 3.2 7.2 9.8 7.1 1.3 11.4 3.7 5.4 6.3 26.9 18.5 8.3 1.7 19.7 6.5 5.7 3.8 20.5 8.1 8.3 3.5 9.9 16.2 4.4 24.0 6.7 6.4 3.9 13.3 7.9 12.1 8.1 1.9 1.5 20.3 2.5 3.3 7.6 10.6 37.1 9.7 11.9 0.9 3.0 6.5 6.7 10.1 4.6 10.5 4.0 4.4 6.6 3.4 17.5 4.7 10.6 17.6 1.9 4.8 2.4 3.8 2.1 3.3 4.0 5.8 20.7 2.0 5.8 7.4 14.2 5.6 6.8 1.0 11.5 8.6 41.1 13.2 13.6 5.1 52.5 7.6 9.5 21.5 10.7 26.0 51.0 9.8 0.7 6.4 2.9 4.7 15.0 8.2 22.1 1.2 6.1 13.2 6.3 3.1 0.7 0.8 4.5 0.7 4.0 2.4 1.1 1.8 3.3 1.5 0.5 1.7 1.7 4.9 1.0 3.8 1.7 3.0 2.6 4.0 2.1 2.1 2.7 3.9 3.2 3.7 3.8 3.5 3.9 20.8 6.4 9.8 17.9 102.5 52.4 15.1 17.1 43.9 14.9 73.2 30.6 3.5 48.6 15.9 36.8 47.9 15.1 31.9 7.3 7.9 18.9 2.0 25.0 20.6 24.0 10.2 14.5 11.7 14.8 8.6 10.7 14.3 43.7 7.6 20.0 21.8 15.0 32.3 28.6 31.8 11.4 6.1 76.0 48.4 3.6 5.3 66.5 37.4 69.3 99.1 11.6 9.2 210.1 12.5 12.9 7.7 1.9 41.5 14.8 10.6 20.7 11.0 38.5 6.6 9.3 11.9 8.6 17.9 69.1 54.7 6.7 31.6 15.4 9.7 12.0 MAP3K10 "MEKK10, MLK2, MST" ENSG00000130758 "Mitogen-activated protein kinase kinase kinase 10" Q02779 19 40191426-40215575 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 46.2" "Cell type enhanced" "Detected in many" "Excitatory neurons: 18.9;Horizontal cells: 23.5" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in many" 8 "amygdala: 22.8;basal ganglia: 17.5;cerebral cortex: 46.2;hippocampal formation: 37.7;white matter: 11.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007039 Approved Approved "Nucleoplasm,Actin filaments,Cytosol" NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 62: Horizontal cells - Visual perception" "Nucleoplasm, Actin filaments, Cytosol" "HPA007039: AB_1079357" "unprognostic (2.09e-1)" "unprognostic (3.77e-2)" "unprognostic (1.42e-3)" "unprognostic (2.03e-2)" "unprognostic (2.04e-1)" "prognostic favorable (8.69e-4)" "unprognostic (4.50e-3)" "unprognostic (1.80e-1)" "unprognostic (3.94e-2)" "unprognostic (6.13e-2)" "unprognostic (1.34e-3)" "unprognostic (4.62e-3)" "unprognostic (6.88e-2)" "unprognostic (1.53e-2)" "unprognostic (1.51e-2)" "unprognostic (4.77e-3)" "prognostic favorable (2.13e-4)" 6.9 8.3 22.8 2.3 17.5 1.9 6.5 0.0 46.2 7.7 0.0 8.6 2.0 7.9 0.3 5.3 6.6 1.8 10.7 37.7 0.1 7.4 5.2 6.7 2.3 3.2 0.6 7.3 6.9 3.3 14.3 1.6 0.0 8.1 0.6 1.4 5.9 2.0 16.8 7.1 6.3 1.8 0.0 8.1 7.1 11.1 2.4 1.8 6.9 4.3 0.9 7.2 6.6 11.6 6.3 7.2 2.2 5.2 2.0 1.2 6.2 4.3 2.0 1.9 1.9 1.7 1.7 5.7 4.4 1.4 4.6 1.9 0.8 2.2 0.2 10.9 6.8 1.4 3.3 1.7 3.8 1.2 3.4 1.1 5.0 2.0 1.4 2.0 1.7 7.6 5.5 9.1 0.5 3.7 4.5 2.2 2.6 2.0 4.7 5.8 2.3 3.4 1.7 3.8 7.4 10.7 4.9 1.7 10.0 1.3 2.4 2.2 2.9 4.9 4.8 7.3 8.3 12.7 7.7 2.6 5.7 2.3 7.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 22.8 17.5 0.0 46.2 37.7 0.1 3.2 0.6 0.0 0.0 2.4 11.6 5.6 0.0 0.0 6.5 4.2 1.5 1.8 1.1 1.2 14.9 2.9 2.4 2.8 5.7 0.5 7.3 8.4 0.9 3.3 2.4 0.0 2.5 2.8 2.4 3.6 3.6 4.2 5.3 18.9 4.3 0.8 2.6 5.6 3.8 0.0 10.3 3.9 3.2 2.5 23.5 15.9 1.7 0.0 1.6 2.9 7.6 3.1 2.7 1.8 9.4 2.5 5.7 4.1 9.0 12.4 3.7 2.9 4.9 1.5 2.5 1.7 3.1 0.6 7.7 6.6 4.5 4.0 4.1 1.8 1.8 2.7 1.4 4.4 3.2 2.4 2.0 MAP3K11 "MEKK11, MLK3, PTK1, SPRK" ENSG00000173327 "Mitogen-activated protein kinase kinase kinase 11" Q16584 11 65597756-65615382 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal enterocytes: 123.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB010165 Approved Supported "Centriolar satellite,Cytosol" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 53: Intestinal epithelial cells - Unknown function" "Centriolar satellite, Cytosol" "CAB010165: AB_631936" "unprognostic (8.36e-2)" "unprognostic (1.17e-2)" "unprognostic (1.06e-1)" "unprognostic (9.99e-2)" "unprognostic (3.40e-1)" "unprognostic (1.87e-1)" "unprognostic (7.56e-3)" "unprognostic (3.10e-2)" "unprognostic (4.50e-2)" "unprognostic (4.30e-1)" "unprognostic (4.69e-2)" "unprognostic (2.77e-2)" "unprognostic (3.13e-2)" "unprognostic (2.01e-2)" "unprognostic (7.62e-2)" "unprognostic (1.95e-1)" "unprognostic (8.27e-3)" 47.6 32.6 39.9 36.9 51.7 24.4 42.9 45.1 48.4 27.2 27.2 40.0 48.3 29.7 7.4 35.6 31.3 13.5 53.2 36.1 38.8 48.5 95.3 62.7 23.7 48.8 50.3 21.0 35.8 12.1 27.8 21.6 44.6 39.2 11.7 2.8 29.1 12.6 20.1 35.9 51.0 10.0 41.5 78.3 36.3 21.3 50.5 19.3 37.3 10.4 11.3 29.2 28.3 60.1 48.0 43.4 23.1 22.6 7.0 8.0 21.7 19.3 11.9 19.9 14.9 43.4 43.9 16.4 65.5 13.0 33.0 40.9 12.2 19.5 7.1 40.2 15.5 50.0 28.2 50.9 18.6 28.9 71.2 12.4 19.1 14.5 13.3 21.6 57.4 21.5 21.6 32.7 10.9 58.2 34.0 50.9 24.2 31.0 48.1 56.1 13.3 36.2 19.2 43.1 19.6 22.9 22.0 58.1 107.7 10.4 46.6 45.8 68.8 31.3 35.8 48.1 32.4 23.3 27.5 15.8 35.3 33.1 75.1 7.5 10.5 13.1 3.1 15.3 3.0 2.7 3.2 4.5 10.1 3.0 2.4 1.8 17.3 2.4 15.4 3.0 1.8 9.5 39.9 51.7 45.1 48.4 36.1 38.8 48.8 50.3 44.6 41.5 50.5 60.1 70.0 22.4 21.1 4.2 22.1 21.0 25.3 18.4 20.5 24.4 28.9 23.4 8.7 31.5 14.1 11.0 25.0 24.7 26.4 123.5 19.6 21.9 13.5 15.4 11.3 78.9 41.9 13.0 4.1 27.5 17.7 11.4 44.4 26.1 26.0 19.6 58.5 56.2 53.3 18.5 3.5 54.9 20.3 50.6 65.5 68.5 9.6 48.3 21.4 21.5 50.2 16.1 23.7 3.0 29.5 33.7 99.0 6.4 15.5 28.1 113.1 27.6 10.3 54.7 32.9 10.5 12.8 12.2 18.3 24.8 30.0 34.3 24.0 28.9 55.2 34.6 MAP3K12 "DLK, MEKK12, MUK, ZPK, ZPKP1" ENSG00000139625 "Mitogen-activated protein kinase kinase kinase 12" Q12852 12 53479669-53500063 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Rod photoreceptor cells: 85.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "ASC diff: 55.9;HHSteC: 53.7;HSkMC: 51.8;hTERT-RPE1: 69.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039936, HPA071996" Enhanced Approved "Nucleoplasm,Plasma membrane" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 35: Non-specific - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 46: Photoreceptor cells - Phototransduction" "Nucleoplasm, Plasma membrane" "HPA039936: AB_10795239, HPA071996: AB_2686481" "unprognostic (4.01e-1)" "unprognostic (3.30e-1)" "unprognostic (8.89e-3)" "unprognostic (6.40e-3)" "unprognostic (1.10e-1)" "unprognostic (2.22e-1)" "unprognostic (6.97e-2)" "unprognostic (3.61e-2)" "unprognostic (2.39e-1)" "unprognostic (2.70e-1)" "prognostic favorable (1.51e-4)" "unprognostic (8.50e-3)" "prognostic unfavorable (5.43e-10)" "unprognostic (1.65e-2)" "unprognostic (2.44e-1)" "unprognostic (1.32e-1)" "unprognostic (1.18e-1)" 12.6 7.6 12.9 5.4 15.2 3.2 10.3 25.9 19.6 23.5 4.3 13.3 3.2 22.9 4.8 4.0 18.5 14.0 8.6 15.6 11.3 8.5 1.7 11.2 4.4 11.9 11.1 21.6 3.6 7.3 22.7 6.4 13.2 9.6 3.8 13.6 4.9 10.9 2.7 5.7 8.9 14.4 8.0 9.0 7.3 9.0 13.0 6.0 8.6 6.3 2.7 14.0 12.2 13.7 0.5 15.1 8.6 14.2 55.9 28.9 1.2 10.1 18.9 10.8 11.0 0.3 1.8 3.5 5.4 10.8 8.7 0.1 4.3 6.8 4.3 4.9 5.4 3.5 8.3 0.0 53.7 0.1 3.6 51.8 5.2 14.6 7.8 69.1 16.9 7.8 0.1 15.7 10.0 6.7 3.8 0.9 3.2 0.0 5.5 5.4 6.3 1.0 5.4 0.1 9.3 12.4 5.6 6.8 14.9 1.8 4.6 10.3 12.9 10.2 10.8 4.5 2.5 6.1 8.0 0.0 16.8 6.9 10.4 0.0 0.5 0.0 0.4 0.4 0.8 0.1 0.5 0.6 0.2 0.0 0.2 0.3 1.0 0.2 0.1 0.0 0.1 0.1 12.9 15.2 25.9 19.6 15.6 11.3 11.9 11.1 13.2 8.0 13.0 13.7 11.4 6.4 14.6 21.5 8.1 0.8 2.4 0.5 4.6 28.9 5.6 5.2 0.8 7.2 6.4 1.8 37.5 1.9 12.2 4.8 9.8 6.7 1.5 11.5 27.6 10.4 3.5 1.3 21.1 1.8 2.2 11.0 2.0 15.8 12.7 7.0 15.0 7.8 4.1 30.3 19.1 2.8 2.0 10.3 2.2 1.8 8.1 8.6 0.0 8.4 8.5 19.9 5.2 10.6 11.0 4.4 2.1 8.2 6.7 5.3 7.1 14.8 5.5 85.0 6.6 23.5 10.2 2.5 2.1 2.5 1.0 2.2 11.6 12.5 4.1 3.9 MAP3K13 "LZK, MEKK13" ENSG00000073803 "Mitogen-activated protein kinase kinase kinase 13" O43283 3 185282941-185489094 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016497, HPA036691, HPA036692" Uncertain Approved "Nucleoplasm,Centriolar satellite,Cytosol" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 68: Epididymis - Unknown function" "Cluster 6: T47d - Mammary gland" "Cluster 22: Epithelial cell types - Mixed function" "Centriolar satellite" "Nucleoplasm, Cytosol" "HPA016497: AB_10670027, HPA036691: AB_10673661, HPA036692: AB_10670845" "unprognostic (8.95e-2)" "unprognostic (6.72e-3)" "unprognostic (9.46e-2)" "prognostic unfavorable (1.28e-5)" "unprognostic (5.16e-2)" "unprognostic (2.81e-1)" "unprognostic (2.61e-1)" "unprognostic (1.23e-2)" "unprognostic (9.04e-2)" "prognostic favorable (1.11e-4)" "prognostic unfavorable (7.27e-5)" "unprognostic (2.70e-3)" "unprognostic (1.54e-2)" "unprognostic (2.94e-2)" "unprognostic (2.82e-1)" "unprognostic (6.64e-2)" "unprognostic (9.31e-3)" 14.7 34.0 18.5 13.0 19.8 15.8 21.0 23.2 25.8 17.0 18.5 24.6 24.3 17.9 56.8 19.7 20.2 18.1 10.4 19.7 20.4 30.9 29.6 17.5 11.7 20.7 21.7 22.2 25.9 34.6 20.7 13.1 21.1 19.7 26.2 36.2 26.2 14.9 4.7 14.0 25.0 17.0 21.2 13.1 23.9 18.8 21.5 11.1 25.7 6.8 15.0 23.2 15.8 23.5 73.9 14.5 27.4 0.7 24.4 29.9 16.1 16.5 11.2 26.2 31.5 27.9 27.0 0.6 55.1 30.4 43.7 41.1 0.8 38.4 46.5 82.1 36.8 0.3 18.9 23.3 26.5 39.2 20.1 27.2 32.8 22.6 28.1 27.1 29.6 0.7 0.9 57.5 23.8 23.0 4.6 18.2 31.5 56.5 33.4 0.6 32.8 40.5 46.9 18.8 44.7 29.8 28.0 41.5 59.9 29.8 62.8 21.5 19.7 21.5 27.8 39.4 36.5 29.3 40.8 24.4 31.4 19.5 36.1 14.0 21.6 9.4 16.6 22.1 25.7 42.8 19.6 21.0 37.4 34.9 27.2 26.6 35.9 20.8 15.9 16.4 8.6 12.4 18.5 19.8 23.2 25.8 19.7 20.4 20.7 21.7 21.1 21.2 21.5 23.5 69.5 54.5 82.7 80.0 41.8 141.6 219.1 196.7 100.7 117.9 144.0 115.1 25.2 144.4 131.6 79.1 91.8 139.5 22.9 96.1 287.6 106.6 134.8 76.5 50.7 65.9 106.4 43.8 170.7 127.5 38.9 49.0 72.4 73.1 29.8 96.6 93.5 99.4 64.9 45.4 184.5 130.9 138.4 53.2 193.0 213.0 43.2 52.7 85.4 28.1 283.9 137.5 22.6 102.1 89.8 137.5 95.1 54.2 40.6 322.2 111.6 283.9 125.7 88.8 46.0 38.5 62.7 119.5 39.1 94.6 145.6 203.4 32.2 50.0 109.3 279.4 MAP3K14 "FTDCR1B, HS, HSNIK, NIK" ENSG00000006062 "Mitogen-activated protein kinase kinase kinase 14" Q99558 17 45263119-45317029 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "monocytes: 33.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "A549: 40.6;U-251 MG: 43.1" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA027269, HPA027270" Approved Supported "Nucleoplasm,Nucleoli fibrillar center,Vesicles,Cytosol" NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 59: Non-specific - Translation" "Cluster 9: U-2 OS - Unknown function" "Cluster 3: Monocytes - Immune response regulation" "Vesicles, Cytosol" "Nucleoplasm, Nucleoli fibrillar center" "HPA027269: AB_2732436, HPA027270: AB_2732437" "unprognostic (1.05e-2)" "prognostic favorable (5.27e-5)" "unprognostic (2.71e-2)" "unprognostic (9.42e-2)" "unprognostic (5.31e-2)" "unprognostic (2.61e-3)" "unprognostic (2.70e-2)" "unprognostic (1.72e-1)" "unprognostic (3.40e-1)" "unprognostic (3.45e-1)" "unprognostic (1.07e-2)" "unprognostic (1.78e-1)" "prognostic unfavorable (2.78e-4)" "unprognostic (8.82e-2)" "unprognostic (3.49e-2)" "unprognostic (1.03e-2)" "unprognostic (2.28e-1)" 5.9 4.7 2.6 12.5 5.0 5.2 6.4 2.9 2.3 7.1 2.8 15.6 8.1 5.7 1.9 7.8 6.6 5.9 9.9 3.2 2.7 5.1 7.3 8.1 17.7 3.6 4.6 6.0 8.3 4.6 5.9 2.7 3.1 7.0 5.2 2.2 8.1 4.7 28.0 8.5 10.3 5.9 2.5 12.4 7.6 6.9 4.8 13.4 5.8 9.9 16.0 7.2 7.1 2.1 17.1 40.6 3.6 6.5 2.4 7.1 9.4 4.5 3.4 14.9 9.1 5.5 21.0 7.4 24.1 5.3 14.6 11.6 1.5 6.5 7.6 24.3 3.1 1.4 10.1 2.1 7.1 1.1 6.9 10.0 3.6 7.3 3.6 15.6 3.0 3.2 2.7 30.1 8.1 6.1 6.8 1.7 1.8 11.1 5.1 9.5 12.1 17.9 10.5 2.6 3.5 3.0 7.6 3.4 5.0 5.5 2.8 0.4 5.6 6.5 10.2 5.7 43.1 29.1 12.1 4.1 3.9 4.0 9.2 0.0 2.0 0.8 1.6 1.8 1.0 4.2 1.1 1.0 1.4 4.4 1.2 0.9 1.6 2.0 0.6 1.7 2.9 1.6 2.6 5.0 2.9 2.3 3.2 2.7 3.6 4.6 3.1 2.5 4.8 2.1 5.8 3.2 12.8 23.5 15.3 0.0 14.7 0.0 14.8 4.5 5.6 4.8 2.3 18.6 2.5 0.0 4.2 0.9 14.5 13.9 0.0 4.8 4.7 7.0 4.0 6.1 13.1 1.3 8.9 2.7 1.5 6.3 10.2 5.6 1.3 2.1 6.4 9.2 4.9 1.7 15.6 7.8 0.0 9.4 0.0 6.2 4.7 11.3 0.0 26.2 33.4 1.9 5.2 6.6 5.5 3.3 9.6 1.2 8.5 6.2 13.4 3.8 5.1 2.9 0.0 12.9 2.8 4.2 3.0 7.9 0.0 0.0 10.6 2.4 8.5 6.8 MAP3K15 "ASK3, bA723P2.3, FLJ16518" ENSG00000180815 "Mitogen-activated protein kinase kinase kinase 15" Q6ZN16 X 19360056-19515261 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 7 "adrenal gland: 10.8;choroid plexus: 13.1" "Cell type enhanced" "Detected in some" "Collecting duct cells: 5.5;Cone photoreceptor cells: 4.2;Granulosa cells: 7.5;Theca cells: 29.8" "Cancer enhanced" "Detected in single" "testis cancer: 0.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 2.0;HAP1: 4.9;HEK 293: 4.1;JURKAT: 2.5;REH: 2.6;SuSa: 4.7" "Low region specificity" "Detected in many" "Low region specificity" "Detected in some" HPA004006 Approved Vesicles NA NA "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 52: Non-specific - Transcription" Vesicles "HPA004006: AB_1079358" "unprognostic (2.87e-1)" "unprognostic (7.09e-2)" "unprognostic (3.21e-2)" "unprognostic (6.56e-8)" "unprognostic (3.47e-2)" "unprognostic (1.42e-2)" "unprognostic (2.19e-3)" "unprognostic (2.35e-2)" "unprognostic (1.46e-1)" "unprognostic (4.87e-2)" "unprognostic (1.30e-2)" "unprognostic (8.95e-2)" "unprognostic (2.77e-3)" "unprognostic (4.00e-1)" "unprognostic (2.37e-1)" "unprognostic (3.98e-2)" "unprognostic (8.20e-2)" 0.0 10.8 0.1 0.0 0.0 0.3 0.0 0.1 0.0 0.0 13.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.7 0.6 1.1 0.0 0.3 0.0 0.0 0.3 0.4 0.5 0.7 0.5 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.6 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.1 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.3 0.0 4.9 0.0 0.0 0.8 4.1 1.7 0.0 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.3 0.0 0.0 0.1 0.0 1.1 1.3 0.0 0.5 2.6 0.0 0.0 0.3 0.0 0.1 0.1 0.0 0.0 0.0 4.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.7 0.6 0.0 0.3 0.4 0.0 0.2 0.0 0.2 0.0 3.1 0.3 0.0 0.1 0.5 0.0 0.0 1.0 0.2 0.6 2.9 0.0 0.0 5.5 4.2 0.0 0.1 0.2 3.9 0.0 0.4 0.3 0.3 0.1 0.0 0.4 2.6 0.0 0.3 0.4 0.0 0.3 0.0 7.5 0.4 0.0 0.1 0.0 2.5 0.0 0.0 0.0 0.0 0.2 0.3 0.2 0.0 1.0 0.0 0.3 0.0 0.5 1.1 0.1 0.0 1.2 0.0 0.2 0.0 0.1 0.0 0.6 0.0 0.3 0.2 0.6 1.4 0.0 0.0 0.1 0.2 29.8 0.1 0.0 MAP3K19 "FLJ23074, RCK, YSK4" ENSG00000176601 "Mitogen-activated protein kinase kinase kinase 19" Q56UN5 2 134964485-135047468 "Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "brain: 5.0;choroid plexus: 9.3;fallopian tube: 18.3;testis: 5.4" "Group enriched" "Detected in some" 8 "Early spermatids: 59.7;Endometrial ciliated cells: 73.7;Late spermatids: 148.4;Respiratory ciliated cells: 121.0" "Cancer enhanced" "Detected in some" "endometrial cancer: 0.8" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA011388 Uncertain Cytosol NA NA "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 25: Spermatids - Spermatogenesis" Cytosol "HPA011388: AB_1848822" "unprognostic (7.12e-3)" "unprognostic (6.55e-3)" "unprognostic (6.96e-2)" "unprognostic (3.90e-3)" "unprognostic (3.63e-1)" "unprognostic (2.21e-1)" "unprognostic (1.96e-1)" "unprognostic (9.38e-2)" "unprognostic (1.09e-1)" "unprognostic (4.33e-1)" "unprognostic (2.02e-2)" "unprognostic (1.32e-1)" "unprognostic (4.04e-6)" "unprognostic (1.50e-1)" "unprognostic (4.13e-2)" "unprognostic (1.54e-1)" "unprognostic (2.83e-4)" 0.0 0.1 1.1 0.0 1.2 0.0 0.0 0.8 0.8 0.5 9.3 0.0 0.0 0.6 0.0 0.0 18.3 0.0 0.1 1.1 1.9 0.0 0.0 1.5 0.1 5.0 3.6 0.0 0.0 0.0 0.3 0.0 3.0 0.1 0.0 0.5 0.1 0.0 0.0 0.1 0.1 0.0 3.8 0.0 0.0 5.4 1.9 0.0 0.0 0.0 0.0 0.0 0.0 3.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 1.2 0.8 0.8 1.1 1.9 5.0 3.6 3.0 3.8 1.9 3.1 0.1 0.0 1.1 2.3 0.1 0.0 0.1 2.6 0.0 0.3 0.0 0.0 0.4 0.0 11.4 0.0 10.4 0.0 0.0 0.0 0.0 0.0 59.7 73.7 0.4 0.0 0.0 0.0 1.3 0.0 0.0 0.3 0.0 1.3 0.0 0.0 0.0 0.0 0.1 0.0 1.3 0.0 2.0 0.0 0.0 148.4 0.3 0.1 0.0 0.0 0.0 0.0 0.0 1.0 1.2 0.0 0.0 0.0 0.0 0.4 0.0 0.0 121.0 0.2 0.0 0.0 0.8 7.5 2.6 0.0 0.0 0.0 0.1 0.0 0.0 0.1 MAP3K2 "MEKK2, MEKK2B" ENSG00000169967 "Mitogen-activated protein kinase kinase kinase 2" Q9Y2U5 2 127298730-127388465 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 11.3" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA021540 Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 44: HDLM-2 - Immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" "Nucleoplasm, Cytosol" "HPA021540: AB_2670742" "unprognostic (5.81e-2)" "unprognostic (2.76e-1)" "unprognostic (1.58e-1)" "unprognostic (9.46e-2)" "unprognostic (1.02e-1)" "unprognostic (5.76e-2)" "unprognostic (7.19e-2)" "unprognostic (4.50e-1)" "unprognostic (1.27e-1)" "unprognostic (4.00e-1)" "unprognostic (1.25e-1)" "unprognostic (1.39e-1)" "unprognostic (4.97e-3)" "unprognostic (7.56e-2)" "unprognostic (8.93e-2)" "unprognostic (8.88e-2)" "unprognostic (2.11e-1)" 12.6 8.9 12.1 13.4 16.3 37.6 10.5 13.5 15.9 12.0 9.9 12.5 15.3 11.2 8.3 9.5 9.0 12.9 6.6 10.3 14.3 11.9 22.3 10.8 12.9 18.0 14.9 10.6 10.6 14.0 7.8 9.9 17.4 8.9 10.1 15.6 10.2 9.0 13.4 12.6 14.1 12.7 15.2 13.5 14.7 11.3 18.3 14.4 17.9 9.1 13.8 10.4 8.3 24.8 29.4 12.3 9.6 9.7 13.2 17.4 16.0 17.9 19.4 17.2 13.9 14.8 12.7 19.2 30.0 25.7 16.0 24.3 15.6 12.0 19.3 48.6 12.1 17.9 22.3 13.0 15.2 18.2 37.2 15.7 12.9 21.0 25.5 15.1 8.1 14.2 8.6 37.3 17.2 10.7 21.4 12.9 9.9 8.2 15.8 14.0 18.0 14.5 7.0 27.1 19.0 10.2 26.1 15.8 16.4 7.8 10.3 13.7 18.7 33.6 31.3 15.7 24.5 38.4 30.0 19.5 16.1 11.7 14.8 3.4 2.5 1.7 1.3 1.5 1.6 2.7 1.2 1.3 2.1 2.2 1.5 1.6 11.3 2.0 2.0 4.2 1.1 1.0 12.1 16.3 13.5 15.9 10.3 14.3 18.0 14.9 17.4 15.2 18.3 24.8 45.7 83.3 46.0 53.8 88.9 72.0 36.9 34.3 55.2 53.6 42.2 32.1 30.1 45.8 44.2 29.5 106.3 20.5 107.9 72.6 13.7 21.2 4.6 77.0 71.0 36.9 45.4 27.8 60.6 34.0 19.8 54.9 42.3 90.2 60.9 42.2 25.4 69.1 47.7 72.3 57.7 40.1 30.5 80.1 113.7 7.6 42.3 107.7 56.9 50.6 79.1 25.9 30.9 49.8 87.7 49.0 28.8 51.9 57.3 48.3 54.5 33.1 58.5 59.2 19.7 69.2 47.4 42.3 52.6 43.5 78.6 26.3 65.5 51.7 31.8 46.1 MAP3K20 "MLK7, MLTK, MLTKalpha, MLTKbeta, MRK, ZAK" ENSG00000091436 "Mitogen-activated protein kinase kinase kinase 20" Q9NYL2 2 173075435-173268015 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 261.9;tongue: 279.7" "Cell type enhanced" "Detected in many" "Adipocytes: 57.5;Alveolar cells type 2: 57.7;Cytotrophoblasts: 52.6;Endometrial stromal cells: 96.7;Granulosa cells: 100.7;Smooth muscle cells: 83.2;Theca cells: 70.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "myeloid DC: 15.5" "Group enriched" "Detected in many" 5 "dendritic cells: 15.5;monocytes: 9.4" "Cell line enhanced" "Detected in many" "U-138 MG: 176.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017205 Approved Supported Cytosol NA Yes "Cluster 28: Myeloid DCs - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 7: Non-specific - Mitochondria" Cytosol "HPA017205: AB_1858933" "unprognostic (2.90e-2)" "unprognostic (9.99e-3)" "unprognostic (4.63e-3)" "unprognostic (1.98e-1)" "unprognostic (7.63e-2)" "unprognostic (5.02e-2)" "unprognostic (2.34e-2)" "unprognostic (3.89e-3)" "unprognostic (2.83e-2)" "unprognostic (9.27e-2)" "unprognostic (4.54e-2)" "unprognostic (1.74e-1)" "prognostic unfavorable (3.41e-6)" "unprognostic (2.34e-1)" "unprognostic (1.86e-1)" "unprognostic (2.23e-1)" "unprognostic (1.19e-2)" 71.0 11.4 9.5 20.5 9.7 4.7 21.4 10.3 8.5 44.9 15.7 65.8 13.0 76.4 18.6 50.0 48.0 31.4 195.7 9.3 12.1 7.5 25.2 22.5 9.8 13.8 14.7 69.5 11.7 49.3 3.8 27.6 11.2 44.0 20.9 2.5 12.4 57.1 261.9 14.1 19.2 75.0 11.1 12.5 31.5 10.6 12.5 11.5 16.4 279.7 10.2 56.1 21.2 9.4 34.6 28.6 22.0 29.1 62.7 92.5 13.8 121.9 94.7 55.9 59.6 19.5 22.2 26.5 31.2 122.5 48.8 22.9 33.1 64.6 124.2 52.0 22.0 43.3 30.5 4.1 24.8 39.3 43.8 74.7 27.2 105.2 164.2 46.3 37.5 28.5 19.8 4.9 36.8 14.8 24.8 19.0 12.2 28.9 16.0 36.2 45.0 0.1 13.6 19.6 12.9 12.4 47.0 11.3 19.7 35.6 12.9 20.9 37.9 176.3 71.4 53.1 27.9 0.1 0.1 5.5 126.2 10.6 18.9 0.2 9.4 0.0 1.0 8.3 1.0 1.6 0.8 1.7 15.5 2.5 0.0 0.8 2.6 0.5 8.2 0.3 0.8 3.4 9.5 9.7 10.3 8.5 9.3 12.1 13.8 14.7 11.2 11.1 12.5 9.4 57.5 38.5 57.7 0.0 2.8 0.0 0.0 0.0 0.0 0.0 20.0 44.4 0.0 0.0 7.4 11.0 0.0 52.6 2.3 0.0 1.9 43.9 0.0 36.7 96.7 14.1 0.0 0.0 0.0 27.6 21.9 36.5 0.0 35.6 5.1 100.7 0.0 0.0 19.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.2 0.0 0.0 15.5 0.0 0.0 0.0 0.0 38.6 0.0 0.0 1.4 0.0 0.0 1.9 13.1 0.0 0.0 0.0 83.2 0.0 0.0 0.0 0.0 21.6 3.6 70.5 0.0 0.0 MAP3K21 "KIAA1804, MLK4" ENSG00000143674 "Mitogen-activated protein kinase kinase kinase 21" Q5TCX8 1 233327724-233385148 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "pancreas: 20.3" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 35.3;Alveolar cells type 2: 10.0;Collecting duct cells: 14.7;Ductal cells: 11.9;Exocrine glandular cells: 9.8;Glandular and luminal cells: 11.7;Proximal tubular cells: 12.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in single" 5 "NK-cell: 1.5" "Lineage enriched" "Detected in single" 5 "NK-cells: 1.5" "Cell line enhanced" "Detected in many" "HEK 293: 27.4" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" HPA007636 Uncertain Approved "Plasma membrane,Cytosol" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 29: Non-specific - Vesicular transport" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 11: Alveolar cells - Smell perception" "Plasma membrane, Cytosol" "HPA007636: AB_1079392" "unprognostic (3.29e-2)" "unprognostic (5.10e-2)" "unprognostic (2.00e-1)" "unprognostic (2.42e-3)" "unprognostic (4.30e-2)" "unprognostic (1.23e-1)" "unprognostic (1.82e-2)" "unprognostic (1.84e-1)" "unprognostic (1.51e-1)" "unprognostic (1.25e-1)" "unprognostic (2.09e-1)" "unprognostic (8.21e-2)" "unprognostic (3.76e-2)" "unprognostic (2.23e-1)" "unprognostic (1.71e-1)" "unprognostic (9.22e-2)" "unprognostic (4.84e-2)" 0.7 3.8 1.8 1.3 1.6 2.1 2.5 5.2 2.4 1.0 0.7 6.3 11.7 1.2 3.3 2.5 4.6 1.7 0.4 1.4 1.4 13.5 5.4 4.5 0.9 1.5 0.3 0.7 20.3 4.3 2.1 0.3 1.7 1.3 6.9 1.0 3.8 2.7 0.0 3.3 10.1 0.6 0.2 0.5 12.4 9.4 1.8 0.4 2.3 0.0 1.3 1.2 1.8 1.3 11.6 19.4 0.4 0.0 0.0 0.0 9.6 0.3 0.0 0.4 0.8 10.8 9.8 1.1 7.7 0.2 3.6 6.0 14.4 5.9 1.2 21.6 27.4 0.1 11.4 0.0 0.7 19.0 4.3 0.2 7.8 0.3 10.9 2.2 0.7 8.7 0.2 3.7 0.0 2.6 6.1 6.8 13.6 13.4 8.4 0.0 0.0 20.7 13.1 4.8 13.9 3.7 6.6 0.3 0.0 1.5 5.6 6.0 0.0 0.0 1.8 0.1 11.5 3.4 4.6 0.0 1.8 5.1 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.1 0.0 0.0 0.0 1.5 0.0 0.1 0.0 0.0 1.8 1.6 5.2 2.4 1.4 1.4 1.5 0.3 1.7 0.2 1.8 1.3 0.9 35.3 10.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 7.0 6.5 0.0 0.0 0.6 14.7 0.0 0.0 0.4 0.0 3.9 11.9 0.0 5.7 1.0 0.3 0.0 0.0 0.0 9.8 0.0 0.5 0.0 11.7 0.0 2.5 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 1.0 0.0 0.0 0.0 0.0 7.6 0.0 0.0 0.7 0.0 0.0 12.9 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.3 0.7 0.0 0.0 0.0 MAP3K3 "MAPKKK3, MEKK3" ENSG00000198909 "Mitogen-activated protein kinase kinase kinase 3" Q99759 17 63622415-63696305 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007764, HPA035410, HPA035411" Uncertain Approved Nucleoplasm NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Nucleoplasm "CAB007764: AB_562314, HPA035410: AB_2674614, HPA035411: AB_2674615" "unprognostic (9.65e-3)" "unprognostic (1.33e-1)" "unprognostic (5.14e-2)" "prognostic unfavorable (1.13e-4)" "unprognostic (1.16e-1)" "unprognostic (4.12e-2)" "unprognostic (1.03e-2)" "unprognostic (1.33e-1)" "unprognostic (1.36e-1)" "unprognostic (9.37e-2)" "unprognostic (1.46e-3)" "unprognostic (5.51e-2)" "unprognostic (2.35e-1)" "unprognostic (2.79e-2)" "unprognostic (4.68e-2)" "unprognostic (1.09e-1)" "unprognostic (3.08e-2)" 30.1 12.3 11.3 23.7 12.4 31.5 23.6 13.9 12.3 21.6 13.6 28.8 8.7 23.8 6.5 17.7 24.2 21.8 40.9 10.5 12.1 22.9 13.9 28.7 22.3 14.9 12.7 24.0 12.9 15.2 13.8 22.9 13.2 22.2 8.5 6.9 15.1 18.4 23.7 19.3 18.7 22.0 13.1 34.5 18.7 17.2 12.9 15.1 18.0 30.3 14.5 23.4 19.1 13.6 22.6 16.3 20.4 20.1 37.7 30.2 9.4 22.0 24.4 27.0 21.2 7.8 4.5 24.2 15.0 43.2 18.7 8.3 13.4 15.5 16.9 21.7 29.3 19.6 22.6 11.0 19.5 15.6 20.1 22.3 10.4 33.6 17.1 16.3 65.7 17.4 12.2 31.1 21.4 15.9 27.3 15.9 12.5 4.5 16.8 14.3 53.0 15.6 9.4 10.3 10.6 25.3 14.6 17.1 17.9 24.9 17.3 14.8 60.5 67.8 17.8 37.3 26.9 30.3 33.6 8.9 14.4 12.0 18.0 15.0 11.4 15.3 2.8 11.8 3.0 2.0 3.4 2.8 4.9 2.4 3.3 3.2 25.1 1.9 12.5 1.9 2.9 3.5 11.3 12.4 13.9 12.3 10.5 12.1 14.9 12.7 13.2 13.1 12.9 13.6 31.6 19.2 14.5 23.5 11.0 7.8 5.4 3.9 5.7 15.8 9.5 8.9 10.3 12.8 5.1 16.5 14.6 3.2 25.8 3.3 9.8 4.5 8.3 10.0 12.3 33.0 4.2 2.1 39.8 8.1 3.3 13.6 3.1 9.3 3.8 7.1 48.2 10.1 16.3 18.5 34.2 3.9 2.0 47.1 13.0 6.4 14.9 35.1 23.2 54.4 42.7 8.8 24.7 31.2 36.1 5.2 1.9 13.2 8.3 8.2 3.7 2.4 5.4 14.0 19.7 21.9 12.9 23.9 17.8 6.1 11.2 1.4 15.6 6.2 4.5 3.8 MAP3K4 "KIAA0213, MAPKKK4, MEKK4, MTK1" ENSG00000085511 "Mitogen-activated protein kinase kinase kinase 4" Q9Y6R4 6 160991727-161117385 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Oligodendrocyte precursor cells: 87.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 31.5" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007625 Uncertain Approved Cytosol NA NA "Cluster 34: Basophils - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 1: K-562 - Erythropoiesis" "Cluster 44: Endometrium - Transcription" Cytosol "HPA007625: AB_1853770" "unprognostic (3.05e-3)" "unprognostic (2.19e-2)" "unprognostic (1.36e-1)" "unprognostic (1.44e-1)" "unprognostic (2.06e-1)" "unprognostic (7.65e-2)" "unprognostic (1.35e-3)" "unprognostic (6.38e-2)" "unprognostic (2.09e-1)" "unprognostic (3.81e-3)" "unprognostic (2.09e-2)" "unprognostic (2.61e-1)" "unprognostic (1.16e-2)" "unprognostic (5.86e-2)" "unprognostic (3.45e-1)" "unprognostic (1.93e-1)" "unprognostic (6.84e-2)" 4.9 3.9 5.1 6.4 4.4 5.8 6.0 9.4 7.7 7.8 0.0 6.0 5.3 9.3 3.6 8.5 7.2 4.5 5.5 6.4 4.8 5.0 4.5 6.2 7.3 2.7 2.0 8.6 6.4 8.0 3.9 7.1 3.6 7.3 5.3 4.1 7.3 6.3 11.1 8.5 5.5 7.6 2.7 6.3 5.8 7.5 3.1 9.6 5.5 10.2 9.8 7.1 6.7 5.6 8.1 9.0 16.8 14.7 9.9 11.9 11.1 9.0 7.9 10.2 10.7 12.6 5.8 16.7 6.4 23.2 14.6 19.7 17.4 18.0 12.4 12.4 14.3 21.8 8.5 12.9 7.9 22.9 10.1 7.6 20.5 10.7 9.6 15.8 13.5 12.4 56.1 18.8 11.0 8.3 15.6 11.9 10.3 5.8 13.8 16.9 15.6 13.3 9.0 5.8 9.7 8.5 17.0 17.8 1.5 14.7 7.4 27.6 13.0 12.4 15.9 11.7 43.3 10.8 9.3 15.3 14.6 23.2 13.2 31.5 4.0 2.7 5.2 3.2 9.3 6.7 7.5 4.8 4.9 9.1 5.2 5.2 0.2 4.1 1.9 6.1 5.7 3.0 5.1 4.4 9.4 7.7 6.4 4.8 2.7 2.0 3.6 2.7 3.1 5.6 19.9 19.2 12.2 32.7 20.8 9.8 10.5 9.7 30.7 18.5 13.3 16.8 20.9 10.0 14.9 14.7 22.9 20.6 17.0 7.1 3.9 9.7 5.5 35.3 55.4 14.5 15.4 12.8 66.1 7.5 11.5 16.1 15.8 39.4 3.8 35.3 6.1 8.3 7.3 23.5 64.5 9.3 6.1 8.2 6.4 4.4 11.5 15.3 0.0 45.9 18.8 14.9 10.3 87.4 57.1 12.5 8.1 12.4 18.2 13.6 9.3 6.9 10.6 29.8 6.6 21.8 19.4 14.7 25.7 28.1 11.8 33.1 25.2 8.1 11.7 16.7 MAP3K5 "ASK1, MAPKKK5, MEKK5" ENSG00000197442 "Mitogen-activated protein kinase kinase kinase 5" Q99683 6 136557046-136792477 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Host-virus interaction, Immunity, Innate immunity, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 88.1" "Cell type enhanced" "Detected in many" "Astrocytes: 383.6;Excitatory neurons: 170.4;Inhibitory neurons: 204.8;Microglial cells: 216.4;Oligodendrocyte precursor cells: 210.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BJ hTERT+: 42.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB007824, HPA063245" Supported Supported Cytosol NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 35: Non-specific - Unknown function" "Cluster 2: Karpas-707 - Immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Cytosol "CAB007824: AB_598175, HPA063245: AB_2684969" "unprognostic (1.37e-1)" "unprognostic (3.21e-2)" "unprognostic (2.85e-2)" "unprognostic (1.38e-1)" "unprognostic (3.19e-1)" "prognostic favorable (6.08e-4)" "unprognostic (8.76e-2)" "unprognostic (1.41e-2)" "unprognostic (2.84e-1)" "unprognostic (1.90e-2)" "prognostic unfavorable (5.91e-4)" "unprognostic (3.97e-1)" "unprognostic (3.75e-2)" "unprognostic (1.37e-1)" "unprognostic (2.72e-1)" "unprognostic (2.72e-2)" "unprognostic (6.59e-3)" 13.2 88.1 21.7 11.7 23.6 14.1 9.5 21.6 18.9 8.4 7.0 8.7 7.3 11.3 7.7 10.0 12.9 7.5 11.3 18.6 18.9 10.6 9.0 11.9 12.1 17.2 20.7 49.3 30.9 1.9 16.2 5.3 16.1 18.0 9.7 14.5 7.1 7.1 6.3 8.0 9.0 5.1 16.6 11.7 14.8 12.0 24.8 8.2 12.8 6.1 12.3 18.5 9.2 15.7 5.6 3.4 0.0 0.0 7.6 20.2 1.9 8.0 42.6 4.0 3.8 0.3 5.6 3.3 11.5 11.1 3.0 7.6 13.6 4.1 10.5 4.6 10.6 28.9 7.6 0.0 36.3 13.6 0.1 26.8 5.3 6.3 17.9 15.4 13.6 4.1 7.3 31.2 28.7 10.9 0.3 11.6 1.3 10.9 4.5 7.6 8.9 13.2 16.2 35.3 9.7 6.4 6.6 6.3 1.8 1.4 1.4 12.0 12.0 6.7 2.1 0.4 7.5 25.3 18.0 0.0 5.3 18.6 6.0 3.5 1.8 2.1 1.5 1.4 2.9 1.1 2.5 2.2 1.5 1.5 0.2 0.8 5.2 2.3 1.4 1.5 4.6 0.9 21.7 23.6 21.6 18.9 18.6 18.9 17.2 20.7 16.1 16.6 24.8 15.7 11.9 6.4 22.0 383.6 14.3 5.0 20.5 32.0 3.4 18.2 10.0 5.0 21.2 4.3 35.1 11.0 6.2 1.0 25.9 12.3 3.9 3.0 6.4 17.3 31.4 7.7 34.8 14.9 170.4 23.1 1.1 12.1 20.9 62.5 5.7 67.7 9.7 11.2 8.0 0.0 204.8 18.2 14.2 23.5 10.2 4.2 23.6 26.6 0.0 216.4 21.7 43.3 12.3 210.1 4.2 17.8 8.7 14.3 13.5 18.8 7.2 8.3 20.5 2.6 13.1 5.3 17.9 3.4 15.5 13.1 10.1 2.7 18.5 16.2 11.2 23.4 MAP3K6 "ASK2, MAPKKK6, MEKK6" ENSG00000142733 "Mitogen-activated protein kinase kinase kinase 6" O95382 1 27354067-27366961 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Adipocytes: 45.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in single" "Low region specificity" "Detected in single" HPA051192 Approved Approved "Nucleoplasm,Plasma membrane,Actin filaments,Cytosol" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Nucleoplasm "Plasma membrane, Actin filaments, Cytosol" "HPA051192: AB_2681380" "unprognostic (1.19e-2)" "unprognostic (2.77e-3)" "unprognostic (2.62e-2)" "unprognostic (1.97e-2)" "prognostic unfavorable (2.13e-4)" "prognostic favorable (7.26e-4)" "prognostic unfavorable (8.76e-4)" "unprognostic (9.10e-2)" "unprognostic (2.79e-1)" "unprognostic (6.91e-2)" "unprognostic (6.56e-2)" "unprognostic (1.25e-1)" "unprognostic (4.65e-3)" "unprognostic (4.95e-2)" "unprognostic (2.79e-1)" "unprognostic (7.07e-3)" "unprognostic (1.50e-1)" 42.9 17.8 17.2 5.5 17.0 0.6 42.6 17.4 20.7 50.2 16.8 25.4 1.8 30.9 4.1 70.0 38.8 4.7 61.8 16.6 17.4 37.3 10.4 54.2 4.7 18.4 17.5 15.6 15.2 5.2 18.0 5.1 17.6 41.3 4.5 1.4 30.3 7.3 15.2 65.7 17.7 12.1 17.3 22.3 23.6 8.3 18.4 2.8 30.3 11.3 7.9 39.8 53.4 16.6 7.2 7.2 6.9 4.4 9.9 12.5 1.4 9.0 5.3 7.2 4.4 2.0 9.4 0.1 8.4 16.4 3.2 10.1 2.0 6.4 3.6 6.5 7.1 0.3 16.0 4.7 2.7 0.5 0.4 10.2 17.6 7.8 2.3 8.8 4.0 0.7 2.0 2.7 10.2 25.1 0.2 9.0 2.2 8.7 8.1 2.3 3.2 1.7 12.9 9.1 2.0 3.0 8.5 7.1 6.3 3.1 4.4 5.0 11.6 13.2 7.2 16.6 5.2 3.5 4.1 0.0 12.1 5.8 4.3 0.9 0.6 3.3 2.8 2.0 3.7 1.5 2.5 3.1 1.3 2.0 1.8 1.6 1.2 0.7 4.5 0.0 3.0 1.2 17.2 17.0 17.4 20.7 16.6 17.4 18.4 17.5 17.6 17.3 18.4 16.6 45.8 19.2 17.8 6.2 3.9 12.5 11.9 8.8 17.1 1.1 8.1 8.9 12.2 5.7 10.3 3.7 0.0 1.2 4.3 8.4 3.9 2.8 0.4 2.3 6.0 27.7 0.0 0.8 1.5 4.4 2.5 10.3 8.6 5.2 2.5 1.2 28.9 0.9 2.8 5.0 1.7 6.1 4.1 8.5 7.1 1.2 16.1 6.4 5.4 5.6 9.3 5.4 8.2 0.0 0.2 12.8 1.9 15.1 3.1 9.5 1.1 1.7 6.2 0.8 6.6 10.8 11.1 13.5 7.7 14.7 14.8 0.1 8.2 0.3 8.8 14.9 MAP3K7 "MEKK7, TAK1" ENSG00000135341 "Mitogen-activated protein kinase kinase kinase 7" O43318 6 90513573-90587072 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Host-virus interaction, Stress response, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 137.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007633, HPA075335" Approved Supported "Nuclear speckles,Plasma membrane,Cytosol" NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 21: Non-specific - Transcription" "Cluster 1: K-562 - Erythropoiesis" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol "Nuclear speckles, Plasma membrane" "HPA007633: AB_1079359, HPA075335: " "unprognostic (1.48e-1)" "unprognostic (3.45e-2)" "unprognostic (1.35e-1)" "unprognostic (6.48e-2)" "unprognostic (1.44e-1)" "unprognostic (1.84e-1)" "prognostic unfavorable (3.51e-4)" "unprognostic (9.77e-2)" "unprognostic (6.51e-2)" "unprognostic (1.98e-2)" "unprognostic (1.44e-1)" "unprognostic (2.79e-1)" "unprognostic (2.56e-3)" "unprognostic (4.76e-2)" "unprognostic (1.95e-1)" "unprognostic (2.08e-1)" "unprognostic (1.17e-1)" 11.8 12.5 13.1 12.5 15.1 8.7 14.3 15.6 17.3 14.3 11.7 11.6 9.2 16.6 16.5 10.6 11.0 12.7 16.9 14.7 14.9 11.4 11.6 10.4 16.4 15.3 13.7 15.8 9.7 16.3 13.0 17.4 15.8 14.9 10.9 23.5 12.1 13.3 16.9 13.9 9.8 14.0 15.3 17.6 10.8 9.9 13.8 20.8 14.7 18.4 16.8 14.3 12.2 22.4 16.7 14.4 41.3 35.6 29.5 39.1 29.0 32.7 37.7 28.8 36.1 18.6 15.5 36.9 20.4 35.6 25.6 17.3 26.3 25.5 48.7 19.0 27.7 32.9 19.9 24.9 30.8 36.9 24.4 32.5 30.5 28.2 34.2 33.1 27.4 31.8 67.0 29.3 41.8 20.3 17.2 31.2 34.0 25.7 18.0 29.3 73.9 18.0 24.2 18.4 20.8 29.5 22.9 15.6 24.8 32.2 15.5 64.7 26.5 23.3 14.7 21.6 30.9 25.9 24.7 15.8 35.7 39.7 35.0 18.2 11.5 18.4 12.8 15.9 14.5 13.0 12.3 12.5 14.6 9.9 13.7 13.4 11.5 17.9 17.6 8.9 20.8 13.4 13.1 15.1 15.6 17.3 14.7 14.9 15.3 13.7 15.8 15.3 13.8 22.4 16.1 16.0 26.9 47.0 24.3 36.3 20.8 19.5 21.6 23.3 17.9 12.3 31.0 14.3 16.9 16.5 27.1 31.8 17.8 12.4 7.9 17.6 3.6 10.9 19.8 21.2 12.1 14.1 85.7 20.9 34.6 23.2 16.3 14.8 13.9 25.9 25.7 20.7 24.3 28.6 63.8 13.7 20.3 27.3 24.6 3.2 26.8 21.7 21.4 36.5 35.2 19.6 16.5 50.8 137.2 20.1 9.1 41.0 18.8 30.1 11.1 16.6 21.4 21.5 19.7 28.0 18.5 25.9 24.9 21.3 37.2 48.4 22.7 18.1 15.1 24.8 MAP3K8 "c-COT, COT, EST, ESTF, MEKK8, Tpl-2" ENSG00000107968 "Mitogen-activated protein kinase kinase kinase 8" P41279 10 30434021-30461833 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Immunity" "Kinase, Serine/threonine-protein kinase, Transferase" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 5 "bone marrow: 332.1" "Cell type enhanced" "Detected in many" "Macrophages: 225.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HMC-1: 44.2" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" "CAB005120, HPA017962" Supported Supported Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 41: Macrophages - Immune response" Cytosol "CAB005120: AB_2140669, HPA017962: AB_1853776" "unprognostic (1.91e-2)" "unprognostic (2.94e-1)" "unprognostic (3.07e-1)" "unprognostic (9.29e-2)" "unprognostic (6.73e-2)" "unprognostic (1.00e-2)" "unprognostic (1.44e-1)" "unprognostic (3.36e-2)" "unprognostic (1.41e-2)" "unprognostic (8.04e-3)" "unprognostic (8.23e-2)" "unprognostic (2.96e-1)" "prognostic unfavorable (8.76e-7)" "unprognostic (1.88e-1)" "unprognostic (1.49e-1)" "unprognostic (1.63e-2)" "unprognostic (5.98e-3)" 69.1 18.8 7.2 39.9 5.8 332.1 31.8 5.9 8.0 15.1 22.1 19.6 8.3 18.3 5.9 23.2 38.0 37.4 18.5 6.7 13.5 12.7 16.2 64.5 33.7 10.7 8.1 12.0 7.4 6.9 8.4 46.5 8.8 11.1 16.4 10.9 12.5 11.2 6.6 36.0 21.1 35.6 9.3 41.7 20.3 3.0 15.9 9.3 14.7 6.1 28.8 49.4 20.4 7.9 15.5 13.7 3.6 7.7 18.3 15.4 17.3 3.8 20.3 8.2 9.6 9.4 34.2 10.3 9.2 8.1 8.1 28.2 8.4 3.7 3.0 23.3 4.4 19.2 25.6 30.8 16.0 6.0 44.2 19.5 2.1 7.4 1.6 7.7 3.6 0.2 8.8 14.7 1.4 8.8 0.2 22.3 1.4 8.3 4.9 1.3 3.0 5.8 7.9 30.8 0.3 1.6 13.7 11.3 1.9 10.0 3.7 12.7 0.1 4.8 4.3 18.0 0.6 22.4 22.7 3.2 6.9 25.3 0.2 45.8 14.7 53.1 15.7 26.4 8.7 20.8 3.3 10.3 14.5 38.0 0.2 6.0 35.5 28.3 38.7 30.0 1.0 10.3 7.2 5.8 5.9 8.0 6.7 13.5 10.7 8.1 8.8 9.3 15.9 7.9 51.0 38.5 49.6 11.8 147.3 116.9 50.0 91.1 109.8 19.0 51.7 24.3 10.1 11.5 67.5 3.7 0.0 29.3 203.6 13.6 1.9 31.4 0.5 149.3 51.4 55.7 12.0 21.2 7.7 11.3 86.8 66.2 33.1 205.6 71.1 1.1 25.0 3.1 128.2 0.0 7.1 6.3 83.4 113.8 205.5 1.1 8.4 225.1 42.7 30.9 64.7 6.1 36.0 2.0 0.7 23.4 20.7 4.1 107.8 46.8 3.9 3.5 78.8 1.6 6.6 23.6 62.3 0.3 0.8 129.1 84.8 159.4 97.8 1.5 6.5 195.6 MAP3K9 "MEKK9, MLK1, PRKE1" ENSG00000006432 "Mitogen-activated protein kinase kinase kinase 9" P80192 14 70722526-70809534 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Stress response, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 22.7;retina: 9.6" "Cell type enhanced" "Detected in many" "Excitatory neurons: 49.6;Inhibitory neurons: 58.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A-431: 22.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000942 Approved Approved Nucleoplasm,Nucleoli "Intracellular and membrane" NA NA "Cluster 6: Brain - Smell perception" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Nucleoli" "HPA000942: AB_1079360" "unprognostic (1.20e-1)" "unprognostic (3.75e-1)" "unprognostic (4.01e-2)" "unprognostic (1.43e-2)" "unprognostic (3.16e-3)" "unprognostic (2.45e-2)" "unprognostic (3.75e-5)" "unprognostic (2.58e-1)" "unprognostic (4.20e-2)" "unprognostic (4.38e-2)" "unprognostic (1.53e-2)" "unprognostic (2.48e-2)" "unprognostic (4.23e-6)" "unprognostic (5.71e-3)" "unprognostic (6.86e-3)" "unprognostic (1.79e-1)" "unprognostic (2.35e-1)" 0.2 1.0 3.3 1.0 4.6 0.7 1.3 10.7 22.7 0.9 0.4 1.5 1.5 0.4 1.5 5.1 1.0 0.4 0.5 4.0 3.2 1.4 0.7 1.9 1.4 8.6 3.0 0.6 2.2 2.7 1.1 0.6 7.7 0.9 1.5 9.6 1.7 0.5 0.8 4.0 1.4 0.2 0.3 0.9 1.6 5.5 10.0 0.9 2.7 0.4 3.6 0.7 1.8 6.8 22.3 10.5 2.0 2.5 0.0 0.0 6.7 0.5 0.3 2.1 1.9 7.8 8.6 4.5 2.8 0.1 4.7 10.3 6.5 12.8 2.2 3.0 1.7 0.2 4.1 5.2 0.3 0.5 0.9 0.1 6.5 1.5 12.7 3.7 0.0 4.1 1.7 1.0 0.5 9.4 3.7 0.5 4.2 9.0 4.5 1.3 3.9 0.9 4.6 10.9 13.8 3.0 6.3 7.7 1.2 3.7 6.9 0.8 0.0 0.0 8.5 0.0 3.5 2.2 5.6 2.4 3.4 0.4 1.4 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.3 0.1 0.1 0.2 0.2 0.0 0.0 0.2 0.0 3.3 4.6 10.7 22.7 4.0 3.2 8.6 3.0 7.7 0.3 10.0 6.8 0.3 6.4 13.4 6.8 3.9 8.7 13.7 9.4 6.8 17.7 11.2 4.8 2.3 14.3 12.4 7.3 12.5 2.8 1.7 5.7 1.9 6.1 19.8 7.4 0.7 0.8 8.4 0.0 49.6 4.8 1.6 1.0 4.1 8.5 1.3 1.8 1.1 4.8 1.2 30.3 58.1 4.0 4.1 0.8 1.9 20.0 0.6 0.8 3.6 5.6 0.4 3.2 0.0 8.5 1.3 11.1 3.9 0.0 2.8 15.8 2.6 2.8 7.1 12.7 0.0 0.8 1.3 8.0 8.4 12.6 9.1 4.0 3.7 6.0 5.8 27.9 MAP4K1 HPK1 ENSG00000104814 "Mitogen-activated protein kinase kinase kinase kinase 1" Q92918 19 38587641-38618882 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 30.1;lymphoid tissue: 56.9" "Cell type enhanced" "Detected in many" "B-cells: 42.6;dendritic cells: 42.6;Langerhans cells: 27.8;Plasma cells: 30.4;Rod photoreceptor cells: 77.9;T-cells: 43.6" "Cancer enhanced" "Detected in all" "testis cancer: 15.2" "Low region specificity" "Detected in some" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in some" "Daudi: 45.2;HDLM-2: 46.4;Karpas-707: 46.9;REH: 25.5;RPMI-8226: 29.8;U-266/70: 36.0;U-266/84: 38.2;U-698: 57.8" "Not detected" "Not detected" "Low region specificity" "Detected in some" "HPA007419, CAB007754" Enhanced Approved "Plasma membrane" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 16: Immune cells - Immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 58: T-cells - T-cell receptor" "Plasma membrane" "CAB007754: AB_562299, HPA007419: AB_1853778" "unprognostic (1.99e-3)" "prognostic favorable (6.17e-5)" "unprognostic (9.50e-3)" "unprognostic (3.27e-1)" "unprognostic (6.03e-2)" "prognostic favorable (3.26e-4)" "unprognostic (4.88e-3)" "unprognostic (5.32e-3)" "unprognostic (2.79e-1)" "unprognostic (2.51e-1)" "unprognostic (3.92e-2)" "unprognostic (2.55e-1)" "prognostic unfavorable (7.99e-10)" "unprognostic (1.72e-1)" "unprognostic (1.83e-1)" "unprognostic (3.18e-2)" "unprognostic (1.50e-2)" 2.7 1.5 0.6 14.6 0.7 9.2 1.7 0.7 1.2 1.6 0.7 5.0 2.7 1.3 0.8 2.8 1.8 2.3 1.7 0.7 0.8 2.7 3.0 6.2 32.2 1.0 0.8 0.9 1.2 0.2 1.8 1.8 0.9 2.5 2.3 16.1 2.8 0.5 0.8 1.9 30.1 0.9 0.8 56.9 3.1 1.5 0.9 13.1 3.2 0.2 29.3 2.9 2.1 0.9 0.2 0.3 0.2 0.6 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.1 45.2 0.7 0.0 0.0 0.1 0.1 0.0 0.0 46.4 0.3 9.8 0.1 0.1 0.0 3.1 0.5 0.1 0.0 0.0 0.0 0.0 0.0 21.3 0.2 46.9 0.1 0.3 11.0 12.0 1.4 0.3 0.1 25.5 0.1 29.8 0.0 0.0 0.4 0.1 0.1 0.2 0.1 0.3 0.2 10.8 0.1 0.1 0.3 0.1 0.1 36.0 38.2 57.8 0.0 13.5 0.1 2.9 4.9 2.0 18.9 9.4 17.4 22.7 15.8 20.1 23.9 15.5 8.6 12.1 0.5 6.1 5.7 22.2 22.2 12.1 0.6 0.7 0.7 1.2 0.7 0.8 1.0 0.8 0.9 0.8 0.9 0.9 0.7 3.2 4.9 0.3 42.6 2.3 0.2 0.4 1.2 6.7 0.7 1.0 0.9 0.0 0.6 0.0 12.5 0.2 42.6 0.1 0.0 0.0 0.0 0.3 0.2 1.6 0.0 5.5 0.7 0.2 0.3 1.5 2.0 0.3 15.8 0.4 1.1 1.1 2.6 1.7 1.0 0.1 0.0 8.8 27.8 0.2 0.0 11.6 3.6 1.9 10.3 11.5 15.5 1.0 0.5 0.0 0.0 0.0 30.4 0.3 0.0 0.2 0.0 77.9 0.0 1.0 0.4 0.7 6.4 0.6 1.0 0.1 43.6 0.3 0.3 0.1 MAP4K2 "BL44, GCK, RAB8IP" ENSG00000168067 "Mitogen-activated protein kinase kinase kinase kinase 2" Q12851 11 64784918-64803241 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Immunity, Innate immunity, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Late spermatids: 46.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007330 Enhanced Approved Vesicles NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 32: U-937 - Innate immune response" "Cluster 58: T-cells - T-cell receptor" Vesicles "HPA007330: AB_1079361" "unprognostic (1.66e-1)" "unprognostic (2.83e-1)" "unprognostic (3.07e-3)" "unprognostic (4.37e-3)" "unprognostic (2.67e-1)" "unprognostic (9.23e-2)" "prognostic unfavorable (3.10e-5)" "unprognostic (4.51e-2)" "unprognostic (3.65e-1)" "unprognostic (5.28e-2)" "unprognostic (1.24e-2)" "unprognostic (1.41e-1)" "unprognostic (2.47e-2)" "unprognostic (2.97e-1)" "unprognostic (1.57e-2)" "unprognostic (1.82e-1)" "unprognostic (1.95e-2)" 5.0 3.9 8.9 6.9 7.2 15.5 4.1 9.8 9.9 4.6 4.9 5.6 3.3 4.8 2.5 2.7 3.8 4.2 4.3 7.6 7.0 5.4 2.0 9.7 17.6 7.8 8.0 3.4 5.0 3.2 5.8 8.9 8.1 4.7 3.0 5.3 6.6 5.8 2.5 3.5 8.9 3.7 6.6 18.0 5.2 4.6 9.7 7.4 7.0 1.5 14.2 4.6 3.5 8.8 9.4 8.4 5.4 9.8 4.7 2.9 12.7 7.0 6.5 8.2 5.8 3.7 4.3 16.4 12.6 8.0 14.5 2.8 6.5 6.8 4.9 21.5 3.1 28.9 12.0 7.9 5.8 15.3 10.4 2.9 3.4 6.4 4.1 5.7 20.3 28.0 2.5 1.5 2.5 11.8 9.2 15.2 3.6 5.6 11.2 18.8 0.6 18.9 4.6 4.7 6.4 9.3 6.0 7.8 6.4 6.1 15.5 23.2 15.8 6.8 15.0 6.3 2.9 1.8 3.8 18.1 6.0 22.8 5.1 2.2 4.3 5.9 4.9 12.5 4.9 9.9 6.5 4.4 4.4 6.6 7.7 6.0 8.0 2.5 15.8 5.0 9.5 7.3 8.9 7.2 9.8 9.9 7.6 7.0 7.8 8.0 8.1 6.6 9.7 8.8 21.6 3.2 4.8 6.8 32.9 1.3 2.8 1.8 6.2 20.6 8.1 10.4 4.7 7.2 2.4 1.8 25.0 7.6 9.4 6.8 3.9 1.7 33.8 2.6 3.8 20.0 6.0 5.0 5.9 1.7 11.3 4.9 9.2 6.0 1.3 7.7 24.3 2.0 11.0 11.8 4.6 1.8 6.1 8.9 3.1 46.8 4.1 16.2 1.8 18.7 13.4 7.2 14.4 2.0 7.2 0.9 16.2 7.2 15.6 1.8 1.6 3.6 1.5 14.6 6.6 3.7 4.3 2.1 13.8 5.2 1.4 5.1 19.9 22.6 2.2 2.0 MAP4K3 "GLK, MAPKKKK3, RAB8IPL1" ENSG00000011566 "Mitogen-activated protein kinase kinase kinase kinase 3" Q8IVH8 2 39249266-39437301 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 118.8;Excitatory neurons: 201.0;Inhibitory neurons: 198.3;Microglial cells: 144.3;Oligodendrocyte precursor cells: 160.4;Oligodendrocytes: 129.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in all" "AF22: 102.3;RT4: 97.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA030380 Approved Approved "Nucleoplasm,Centriolar satellite" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 44: Endometrium - Transcription" "Centriolar satellite" Nucleoplasm "HPA030380: AB_10601132" "unprognostic (4.82e-2)" "unprognostic (7.22e-2)" "unprognostic (5.87e-3)" "unprognostic (7.34e-3)" "unprognostic (6.77e-2)" "unprognostic (2.57e-1)" "unprognostic (1.05e-2)" "unprognostic (6.73e-2)" "unprognostic (1.66e-1)" "unprognostic (6.73e-2)" "unprognostic (4.33e-3)" "unprognostic (4.26e-2)" "unprognostic (2.12e-1)" "unprognostic (3.08e-2)" "unprognostic (3.30e-1)" "unprognostic (2.43e-1)" "unprognostic (5.08e-2)" 15.8 17.1 11.6 6.7 12.5 10.5 16.6 21.6 16.7 15.0 15.3 15.5 13.2 17.2 13.4 10.2 13.6 14.7 19.3 14.2 11.2 24.5 15.1 13.3 6.1 9.9 10.0 20.2 12.2 25.3 12.2 27.4 10.0 16.9 13.0 28.0 10.8 14.0 30.9 16.4 14.3 14.5 11.3 11.6 26.6 21.3 10.2 8.1 24.4 22.2 6.1 18.3 11.4 14.4 25.6 15.6 102.3 16.3 16.3 32.4 28.0 22.1 28.3 21.6 18.3 13.3 12.6 5.5 24.3 15.3 22.1 13.6 39.0 19.7 32.6 6.3 16.0 9.2 10.8 30.9 42.3 4.0 14.5 29.3 19.0 28.1 30.1 22.6 18.8 5.0 12.1 9.9 29.2 13.9 9.0 6.0 30.7 24.0 23.4 9.9 33.3 4.2 28.3 97.3 18.2 20.7 12.9 20.7 58.8 32.0 13.9 5.6 15.4 16.7 19.7 15.0 12.1 15.1 9.3 1.9 20.5 6.6 19.0 0.7 0.1 0.0 0.2 0.2 0.0 0.0 0.2 0.1 0.0 0.1 0.2 0.2 0.0 0.2 0.4 0.1 0.1 0.0 11.6 12.5 21.6 16.7 14.2 11.2 9.9 10.0 10.0 11.3 10.2 14.4 36.2 3.2 8.4 118.8 8.1 17.6 17.9 11.0 16.5 24.7 14.1 12.3 38.2 21.5 16.5 22.0 25.0 13.1 4.1 12.5 19.6 10.3 45.1 22.3 19.9 20.6 9.6 4.6 201.0 12.4 6.7 18.2 25.5 59.4 2.5 15.6 14.3 18.6 9.7 6.7 198.3 13.9 2.0 10.9 20.6 103.0 20.8 14.4 5.4 144.3 4.4 13.2 3.1 160.4 129.2 17.5 5.7 17.7 14.3 18.6 14.0 11.9 19.5 37.9 19.7 18.7 17.6 22.6 19.8 11.8 19.2 10.4 5.9 17.4 10.6 30.2 MAP4K4 "FLH21957, HGK, NIK" ENSG00000071054 "Mitogen-activated protein kinase kinase kinase kinase 4" O95819 2 101696850-101894689 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 5 "brain: 472.1" "Cell type enhanced" "Detected in many" "Microglial cells: 337.3;Oligodendrocytes: 1134.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008476 Uncertain NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 70: Brain - Nervous system development" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "HPA008476: AB_1079362" "unprognostic (6.40e-2)" "unprognostic (1.09e-2)" "unprognostic (4.01e-1)" "unprognostic (1.89e-1)" "unprognostic (1.88e-1)" "unprognostic (1.87e-2)" "unprognostic (2.83e-2)" "prognostic unfavorable (1.57e-4)" "unprognostic (4.29e-2)" "unprognostic (9.79e-2)" "unprognostic (2.22e-3)" "unprognostic (8.65e-2)" "prognostic unfavorable (3.62e-6)" "unprognostic (6.67e-3)" "unprognostic (8.98e-2)" "unprognostic (3.15e-1)" "unprognostic (7.14e-3)" 54.1 9.1 272.6 42.9 316.1 72.5 32.2 208.8 252.5 23.9 95.0 21.1 10.6 27.4 12.1 35.2 19.7 34.5 44.8 219.4 256.3 15.0 32.8 29.2 54.1 317.5 286.1 23.1 16.1 15.0 10.0 49.4 273.1 13.9 17.8 22.7 19.3 10.2 37.4 21.1 17.7 28.7 246.7 24.2 22.0 40.1 348.5 44.3 15.8 30.6 60.1 33.1 25.6 472.1 112.7 83.8 175.2 84.3 162.4 288.6 219.5 139.8 114.3 122.2 100.1 139.5 145.6 163.1 118.3 210.3 36.0 45.5 56.0 123.2 121.1 219.8 38.0 122.4 62.5 367.7 136.7 59.1 5.5 261.3 55.3 301.9 133.5 122.1 322.5 90.3 80.9 0.4 325.4 61.3 137.8 36.5 89.2 42.5 131.5 164.1 120.0 0.6 81.2 38.8 68.5 113.6 96.5 0.4 104.0 160.8 22.4 105.1 409.1 240.5 102.9 70.6 168.6 0.3 0.4 96.7 155.2 73.2 180.1 8.8 3.2 0.0 2.3 3.2 1.6 3.4 2.9 1.5 1.1 5.0 2.2 2.5 13.5 1.1 3.1 6.0 3.7 1.5 272.6 316.1 208.8 252.5 219.4 256.3 317.5 286.1 273.1 246.7 348.5 472.1 104.3 19.2 23.9 283.0 64.5 30.0 41.9 17.4 12.5 109.1 14.3 17.4 71.0 28.6 29.6 18.4 50.1 13.1 38.4 12.0 0.0 57.4 31.5 67.2 77.1 84.2 17.4 48.0 197.5 53.2 23.4 49.7 26.5 101.0 24.0 151.8 67.1 39.2 38.8 35.3 122.4 13.6 14.2 26.9 245.9 46.0 55.0 54.7 19.6 337.3 88.0 49.2 10.3 228.7 1134.5 128.1 12.0 17.3 18.0 72.1 5.3 6.3 22.9 10.4 52.6 65.2 73.3 29.0 82.1 24.3 24.6 7.8 38.4 17.2 14.4 40.4 MAP4K5 "GCKR, KHS, KHS1" ENSG00000012983 "Mitogen-activated protein kinase kinase kinase kinase 5" Q9Y4K4 14 50418501-50561126 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocyte precursor cells: 332.7;Oligodendrocytes: 707.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 5 "basophil: 66.7;eosinophil: 26.3" "Lineage enriched" "Detected in all" 7 "granulocytes: 66.7" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036696, HPA078030" Uncertain Approved "Plasma membrane,Cytosol" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 70: Brain - Nervous system development" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol "Plasma membrane" "HPA036696: AB_10672362, HPA078030: " "unprognostic (1.39e-1)" "unprognostic (1.00e-1)" "unprognostic (3.80e-1)" "unprognostic (1.66e-1)" "unprognostic (4.41e-2)" "unprognostic (1.43e-1)" "unprognostic (8.58e-3)" "unprognostic (4.13e-2)" "unprognostic (6.31e-2)" "unprognostic (2.24e-2)" "unprognostic (1.53e-3)" "unprognostic (7.34e-2)" "unprognostic (1.78e-2)" "unprognostic (3.71e-2)" "unprognostic (1.40e-1)" "unprognostic (9.58e-3)" "unprognostic (2.02e-2)" 20.5 12.8 16.2 13.2 31.1 22.1 22.2 20.7 21.5 30.6 3.9 20.8 13.1 33.4 12.9 20.5 19.0 21.5 10.9 18.3 23.9 11.9 10.0 17.1 12.4 28.4 22.0 32.4 14.2 14.8 11.8 19.8 24.8 17.9 16.6 18.6 18.0 21.1 12.3 28.5 14.7 24.7 17.6 15.7 16.8 7.9 23.8 11.6 17.0 14.2 13.2 20.2 23.8 58.1 51.7 15.2 36.5 31.5 33.0 34.5 35.6 59.2 53.0 39.4 34.9 19.3 35.2 35.3 34.3 54.6 20.9 36.1 34.3 31.9 59.7 29.4 24.8 21.7 27.1 17.5 27.9 19.6 33.0 25.2 25.7 34.8 36.1 63.0 52.6 31.7 20.8 22.5 58.6 19.4 26.6 18.7 17.7 16.6 29.5 31.8 55.4 13.5 39.2 39.5 11.7 26.5 33.5 23.0 23.4 29.3 25.8 14.7 53.8 50.9 35.7 35.2 28.2 16.3 18.0 23.6 19.2 13.5 37.2 66.7 2.8 26.3 6.7 3.3 3.8 6.1 4.2 5.9 3.0 9.7 4.4 4.6 1.0 10.1 2.2 4.9 1.0 1.9 16.2 31.1 20.7 21.5 18.3 23.9 28.4 22.0 24.8 17.6 23.8 58.1 40.5 41.7 20.8 135.2 29.9 70.0 42.9 21.4 56.3 56.7 32.6 26.5 10.5 30.0 27.4 27.6 47.9 11.4 30.6 27.5 19.6 29.5 3.7 25.7 52.2 40.4 23.4 46.7 144.2 20.9 19.5 50.1 43.8 49.1 29.8 37.8 38.6 9.0 8.1 33.7 144.1 16.4 8.2 12.3 24.8 3.7 42.6 25.1 23.2 101.2 18.3 19.5 18.6 332.7 707.2 25.9 20.2 51.1 27.0 57.4 10.9 12.0 25.6 33.1 13.1 49.7 41.7 10.6 14.1 54.9 86.1 6.6 31.5 22.4 18.6 61.7 MAPK1 "ERK, ERK2, MAPK2, p41mapk, PRKM1, PRKM2" ENSG00000100030 "Mitogen-activated protein kinase 1" P28482 22 21759657-21867680 "Cancer-related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins" "Apoptosis, Cell cycle, Host-virus interaction, Transcription, Transcription regulation" "DNA-binding, Kinase, Repressor, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "K-562: 341.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003995, CAB004229, HPA005700, HPA030069, CAB079930, CAB079932, CAB079933" Enhanced Supported "Nuclear speckles,Cytosol" NA NA 140000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 65: Brain - Ion transport" "Cluster 1: K-562 - Erythropoiesis" "Cluster 63: NK-cells & T-cells - Immune response" Cytosol "Nuclear speckles" "CAB004229: AB_627547, CAB079930: , CAB079932: , CAB079933: , HPA003995: AB_1078751, HPA005700: AB_1078750, HPA030069: AB_10602035" "unprognostic (9.41e-3)" "unprognostic (2.68e-1)" "unprognostic (2.50e-3)" "unprognostic (4.17e-1)" "unprognostic (4.44e-3)" "unprognostic (1.72e-1)" "prognostic unfavorable (4.95e-4)" "unprognostic (2.29e-1)" "unprognostic (1.67e-1)" "unprognostic (1.58e-1)" "unprognostic (8.43e-3)" "unprognostic (1.04e-1)" "unprognostic (1.35e-2)" "unprognostic (2.08e-1)" "unprognostic (1.94e-1)" "unprognostic (1.41e-1)" "unprognostic (6.49e-2)" 31.1 33.1 64.8 35.9 84.4 41.2 29.8 37.3 80.9 31.4 32.9 36.1 25.8 29.6 30.1 43.0 29.0 28.9 42.2 91.3 46.4 42.1 34.2 38.5 36.8 29.1 45.1 29.2 38.1 51.7 12.0 33.1 35.9 32.8 36.2 30.3 28.9 32.7 38.1 45.0 29.5 39.1 43.8 40.5 33.9 43.7 60.1 44.4 46.1 41.9 41.9 35.5 18.9 43.2 78.7 48.0 60.5 37.2 75.9 76.7 25.9 84.7 77.5 73.2 72.0 43.8 40.8 45.8 41.3 112.7 67.5 74.6 73.9 67.9 97.8 180.4 72.1 78.9 43.0 67.7 73.5 113.2 80.5 56.9 60.1 89.4 81.6 58.0 101.7 45.4 341.9 50.5 97.5 36.6 72.0 38.5 24.4 104.5 46.8 79.4 149.6 13.2 55.5 62.9 50.0 28.6 91.5 64.2 57.2 60.4 42.4 47.1 90.1 61.5 79.6 71.9 54.2 47.1 59.4 65.8 60.0 60.0 68.4 1.4 4.9 7.2 15.9 6.0 4.9 2.3 3.6 6.0 4.1 2.6 3.5 6.1 16.5 9.3 6.9 4.0 3.4 4.0 64.8 84.4 37.3 80.9 91.3 46.4 29.1 45.1 35.9 43.8 60.1 43.2 36.8 48.1 35.8 97.6 44.0 60.2 28.4 25.1 28.5 25.5 32.5 24.5 41.5 42.9 31.2 51.5 54.2 21.8 151.7 74.4 19.6 28.5 49.0 33.5 40.3 39.9 59.6 63.8 109.2 39.2 23.2 38.4 52.0 45.0 92.8 28.8 52.1 63.5 53.2 28.6 91.2 42.2 26.4 89.0 77.1 14.7 32.6 74.9 40.9 68.4 75.0 35.8 143.2 82.4 75.1 45.3 35.2 44.4 37.0 43.8 32.8 46.0 32.2 22.4 32.9 44.6 37.3 74.1 53.4 44.9 61.8 19.2 91.4 43.3 38.6 38.8 MAPK10 "JNK3, p493F12, p54bSAPK, PRKM10" ENSG00000109339 "Mitogen-activated protein kinase 10" P53779 4 85990007-86594625 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Biological rhythms" "Kinase, Serine/threonine-protein kinase, Transferase" "Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 91.3" "Cell type enhanced" "Detected in many" "Astrocytes: 902.0;Excitatory neurons: 1018.9;Inhibitory neurons: 727.8;Late spermatids: 400.5;Oligodendrocyte precursor cells: 596.6;Oligodendrocytes: 302.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enriched" "Detected in many" 6 "AF22: 155.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB022625 Approved NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 10: Brain - Neuronal signaling" "Cluster 12: NES - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "CAB022625: " "unprognostic (2.46e-2)" "unprognostic (4.36e-2)" "unprognostic (1.13e-1)" "unprognostic (4.05e-2)" "unprognostic (5.17e-2)" "unprognostic (2.03e-1)" "unprognostic (4.59e-2)" "unprognostic (4.82e-2)" "unprognostic (3.81e-2)" "unprognostic (4.45e-2)" "unprognostic (1.18e-3)" "unprognostic (3.02e-2)" "prognostic favorable (3.11e-4)" "unprognostic (1.92e-2)" "unprognostic (1.44e-1)" "unprognostic (6.22e-3)" "prognostic favorable (5.57e-4)" 26.1 15.6 45.2 5.1 61.6 14.5 7.4 25.4 91.3 17.5 23.5 5.7 3.6 14.5 18.8 9.8 15.8 13.8 6.9 60.4 24.9 20.4 3.2 8.6 5.2 29.0 36.2 14.7 7.4 10.3 25.5 4.3 31.4 22.4 5.4 18.3 4.7 24.2 2.6 4.6 5.1 15.5 24.9 7.4 6.6 26.4 39.2 3.4 20.5 4.2 4.6 14.0 18.4 55.6 2.9 4.9 155.0 4.8 4.1 3.6 5.6 3.2 2.9 2.7 1.2 3.3 4.4 7.1 5.1 1.9 3.8 9.4 1.8 4.2 4.3 4.9 4.0 5.7 7.3 4.6 3.6 2.7 3.1 4.1 1.9 3.7 5.0 5.5 3.5 4.8 5.2 27.9 1.7 3.5 4.4 3.1 8.8 0.7 3.2 4.9 4.0 2.5 10.7 16.9 9.2 8.4 3.3 5.9 2.2 5.0 8.8 3.3 7.5 6.3 6.4 3.0 2.7 8.2 5.1 4.4 9.9 3.5 3.8 3.3 0.7 1.2 0.8 0.7 1.0 1.3 0.7 1.0 0.6 1.1 1.0 1.4 4.4 1.2 0.7 1.2 1.2 0.9 45.2 61.6 25.4 91.3 60.4 24.9 29.0 36.2 31.4 24.9 39.2 55.6 4.3 22.4 33.8 902.0 1.6 0.8 15.7 5.5 4.0 26.1 3.2 3.7 1.6 8.6 12.8 22.0 6.2 0.3 0.1 0.0 11.7 2.4 219.5 61.1 25.1 1.3 2.4 0.0 1018.9 0.0 0.5 16.9 2.0 7.1 2.5 6.2 1.1 0.0 0.3 38.7 727.8 0.0 4.1 0.3 0.0 400.5 26.4 1.5 1.8 185.5 0.0 15.7 0.0 596.6 302.8 2.0 0.0 54.9 0.1 7.6 0.0 22.6 68.9 10.8 6.6 7.2 18.5 10.5 5.5 1.3 1.0 0.1 0.9 28.5 0.0 22.6 MAPK11 "p38-2, p38Beta, PRKM11, SAPK2" ENSG00000185386 "Mitogen-activated protein kinase 11" Q15759 22 50263713-50270767 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "Stress response, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 70.9" "Cell type enhanced" "Detected in many" "Adipocytes: 29.5;Astrocytes: 16.6;Endothelial cells: 21.1;Excitatory neurons: 15.8;Hepatic stellate cells: 20.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB012961, HPA045069" Approved Approved Mitochondria NA NA "Cluster 57: Non-specific - Angiogenesis" "Cluster 17: WM-115 - Nervous system development" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Mitochondria "CAB012961: AB_2533144, HPA045069: AB_2679207" "unprognostic (1.11e-1)" "unprognostic (1.28e-1)" "unprognostic (1.49e-2)" "unprognostic (1.92e-1)" "unprognostic (1.18e-2)" "unprognostic (1.64e-3)" "unprognostic (1.02e-1)" "unprognostic (5.84e-2)" "unprognostic (5.89e-2)" "unprognostic (2.46e-1)" "unprognostic (4.96e-3)" "unprognostic (2.18e-1)" "prognostic unfavorable (6.02e-6)" "unprognostic (9.84e-2)" "unprognostic (4.25e-2)" "unprognostic (9.16e-2)" "unprognostic (2.10e-2)" 27.5 6.8 52.3 7.9 56.0 1.1 24.0 48.2 70.9 15.1 40.6 7.3 1.9 15.5 5.8 9.4 16.7 8.7 18.9 55.2 49.6 18.6 4.8 16.8 9.4 48.2 47.2 12.5 5.7 5.4 28.4 8.3 48.2 18.2 2.6 8.6 7.2 7.2 6.4 7.5 8.3 9.4 47.4 16.3 10.9 6.1 50.2 3.5 11.0 5.8 6.1 11.6 12.3 51.0 2.8 6.8 7.4 27.8 9.5 14.3 0.2 10.2 7.4 6.8 2.7 2.8 5.2 0.0 8.7 9.9 11.3 6.9 4.9 4.2 0.5 13.9 3.4 10.1 10.4 0.6 10.9 2.5 15.0 19.9 12.3 1.9 0.8 7.7 15.2 10.6 8.1 26.8 6.9 12.4 0.5 9.4 0.6 8.4 7.7 26.7 0.1 9.9 10.3 0.0 6.8 18.4 9.0 3.7 7.7 0.9 12.2 7.9 24.0 20.4 16.5 1.5 3.7 1.2 3.2 11.8 10.4 2.9 17.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 52.3 56.0 48.2 70.9 55.2 49.6 48.2 47.2 48.2 47.4 50.2 51.0 29.5 0.0 1.1 16.6 2.2 1.9 1.8 3.2 8.0 3.3 1.1 1.5 6.6 1.5 1.7 0.0 6.2 0.0 1.8 0.1 1.9 1.0 4.7 0.6 1.8 21.1 0.0 0.4 15.8 0.2 0.4 2.7 0.5 1.7 0.0 0.1 20.0 2.1 0.3 0.0 3.6 0.2 2.0 1.3 2.1 9.7 3.1 0.5 5.4 13.1 0.1 5.9 0.0 1.0 0.9 0.7 0.0 2.2 1.6 2.9 0.0 1.9 1.3 11.4 0.0 0.6 1.8 1.3 3.2 1.8 1.3 0.0 3.3 0.7 0.1 1.1 MAPK12 "ERK6, p38gamma, PRKM12, SAPK-3, SAPK3" ENSG00000188130 "Mitogen-activated protein kinase 12" P53778 22 50245450-50261716 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Stress response, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 8 "skeletal muscle: 279.7;tongue: 120.9" "Cell type enhanced" "Detected in many" "Adipocytes: 23.1;Astrocytes: 22.9;Endothelial cells: 15.8;Hepatic stellate cells: 20.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Region enhanced" "Detected in all" "cerebellum: 31.6" "Low region specificity" "Detected in all" "CAB025483, HPA054562" Enhanced Approved "Nuclear speckles,Cytosol" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 80: Striated muscle - Unknown function" "Cluster 25: RPMI-8226 - Immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Nuclear speckles" Cytosol "CAB025483: , HPA054562: AB_2682524" "unprognostic (3.68e-2)" "unprognostic (1.72e-1)" "unprognostic (4.53e-3)" "unprognostic (1.54e-1)" "unprognostic (3.22e-2)" "unprognostic (6.35e-3)" "unprognostic (3.90e-3)" "unprognostic (3.16e-2)" "unprognostic (6.02e-2)" "unprognostic (5.70e-2)" "unprognostic (3.48e-2)" "unprognostic (1.07e-1)" "prognostic unfavorable (5.00e-6)" "unprognostic (2.57e-1)" "unprognostic (8.88e-2)" "unprognostic (1.11e-2)" "unprognostic (4.28e-3)" 11.0 2.3 15.6 3.8 16.5 1.3 7.9 15.5 21.2 11.4 9.2 4.7 3.5 19.0 9.8 6.3 11.2 4.4 15.7 15.1 16.5 10.7 1.4 6.8 4.1 17.1 14.9 10.6 1.8 4.3 25.1 4.1 14.6 10.0 1.1 1.4 4.3 6.9 279.7 1.5 4.4 8.6 14.6 4.3 5.0 4.6 15.2 0.9 3.2 120.9 1.4 6.0 5.9 13.9 23.2 13.9 5.3 16.3 12.4 13.5 7.5 17.5 15.1 28.2 18.3 19.6 7.2 45.1 23.4 19.6 16.8 15.4 24.3 3.4 5.5 12.8 34.0 29.2 46.7 24.9 37.7 28.4 54.5 29.8 6.0 7.2 0.0 16.8 33.2 4.0 26.3 38.5 13.4 12.8 0.0 35.4 15.9 7.6 22.5 41.4 14.2 43.9 17.5 3.0 18.0 6.5 13.3 0.5 22.1 4.2 7.1 29.6 18.7 28.5 26.1 6.6 11.2 9.3 7.3 24.5 7.2 24.7 11.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 15.6 16.5 15.5 21.2 15.1 16.5 17.1 14.9 14.6 14.6 15.2 13.9 23.1 0.0 3.2 22.9 1.6 0.8 0.7 3.3 1.2 5.5 1.2 1.3 8.8 4.3 0.8 0.0 0.0 0.3 0.9 0.3 1.9 0.5 0.3 0.6 10.0 15.8 1.8 1.7 9.8 0.0 2.8 5.3 2.6 0.7 10.8 0.6 20.7 0.9 6.3 1.7 6.5 0.2 8.2 2.2 0.8 1.9 6.5 2.2 0.0 6.5 0.6 8.1 0.0 5.0 0.9 0.5 0.0 3.8 2.8 3.6 0.4 8.0 0.9 2.2 6.6 3.3 3.0 0.7 12.1 0.8 0.6 0.4 2.2 3.2 0.3 0.2 MAPK13 "p38delta, PRKM13, SAPK4" ENSG00000156711 "Mitogen-activated protein kinase 13" O15264 6 36127809-36144524 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Stress response, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 102.4" "Cell type enhanced" "Detected in many" "Distal enterocytes: 146.2;Late spermatids: 282.5;Proximal enterocytes: 178.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HBEC3-KT: 63.8;RPMI-8226: 40.2;RT4: 47.0" "Low region specificity" "Detected in single" "Region enriched" "Detected in all" 14 "cerebellum: 37.5" "HPA007667, CAB025854" Enhanced Approved "Nucleoplasm,Nucleoli,Nucleoli rim,Cytosol" NA NA "Cluster 35: T-regs - Unknown function" "Cluster 24: Salivary gland - Salivary secretion" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 30: Mammary glandular cells - Lactation" "Nucleoplasm, Nucleoli, Nucleoli rim, Cytosol" "CAB025854: , HPA007667: AB_1079867" "unprognostic (6.36e-2)" "unprognostic (6.88e-2)" "unprognostic (2.93e-1)" "unprognostic (6.64e-3)" "unprognostic (1.13e-2)" "unprognostic (4.80e-2)" "unprognostic (4.30e-3)" "unprognostic (5.28e-2)" "unprognostic (1.77e-1)" "unprognostic (2.14e-2)" "unprognostic (1.57e-1)" "unprognostic (7.21e-2)" "prognostic favorable (9.00e-4)" "unprognostic (3.12e-2)" "unprognostic (1.70e-1)" "unprognostic (2.21e-2)" "unprognostic (1.41e-1)" 8.7 55.9 3.1 8.8 3.0 9.4 14.2 0.5 4.4 18.6 0.0 44.6 30.9 3.4 11.5 102.4 7.6 7.5 2.5 2.9 2.2 17.3 6.7 23.8 7.9 0.6 0.0 5.4 47.7 38.9 33.3 5.6 0.2 16.7 24.4 2.7 49.5 15.5 1.2 74.1 40.1 1.9 0.1 16.1 24.1 40.0 4.2 6.9 18.9 1.0 12.4 12.2 39.3 2.7 31.4 0.3 0.7 0.5 2.4 11.2 4.3 3.3 0.4 0.3 0.8 22.3 28.4 7.0 2.0 2.5 4.6 24.4 0.3 63.8 0.7 20.0 7.9 0.2 1.2 22.8 4.0 0.4 2.2 9.2 25.9 4.3 1.0 4.5 4.1 1.2 0.6 9.4 0.9 12.7 0.4 2.6 0.4 30.9 0.4 21.0 0.5 40.2 11.6 47.0 30.5 0.7 2.5 0.5 0.2 1.3 33.0 4.1 6.3 2.4 0.4 1.0 0.7 0.8 12.7 2.3 0.1 1.3 0.2 7.6 0.4 6.5 18.3 0.1 12.3 13.9 14.5 15.4 0.1 22.0 12.8 14.4 4.6 3.8 0.1 0.2 38.0 8.6 3.1 3.0 0.5 4.4 2.9 2.2 0.6 0.0 0.2 0.1 4.2 2.7 1.5 28.9 33.0 1.0 16.4 27.3 43.5 24.9 15.4 0.7 58.8 17.7 1.7 25.8 27.3 29.5 6.2 55.3 14.9 146.2 15.6 56.9 110.3 9.1 2.8 2.1 65.5 0.0 10.0 115.9 11.8 5.0 32.1 26.2 2.5 21.1 1.1 1.7 40.3 0.0 6.7 83.2 34.6 6.8 3.3 282.5 7.2 8.8 17.8 3.7 14.2 2.1 21.6 1.5 1.2 103.6 102.2 9.8 11.4 37.1 178.4 11.5 3.7 2.4 0.0 2.2 3.4 56.6 2.9 62.6 53.3 32.3 18.5 2.5 93.0 59.9 MAPK14 "CSBP1, CSBP2, CSPB1, Mxi2, p38, PRKM14, PRKM15" ENSG00000112062 "Mitogen-activated protein kinase 14" Q16539 6 36027677-36111236 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Stress response, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 104.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 5 "basophil: 79.0;neutrophil: 24.9" "Lineage enriched" "Detected in all" 7 "granulocytes: 79.0" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010285, CAB040578, HPA051825" Approved Supported "Nuclear speckles,Cytosol" NA NA 970000 "Cluster 38: Basophils - Unknown function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 32: U-937 - Innate immune response" "Cluster 19: Monocytes & Neutrophils - Innate immune response" "Nuclear speckles" Cytosol "CAB010285: AB_632140, CAB040578: , HPA051825: " "unprognostic (6.76e-3)" "unprognostic (6.28e-2)" "unprognostic (6.30e-3)" "unprognostic (3.30e-3)" "unprognostic (6.98e-2)" "unprognostic (4.04e-2)" "unprognostic (8.10e-2)" "unprognostic (1.93e-1)" "unprognostic (2.20e-3)" "unprognostic (8.39e-2)" "unprognostic (6.27e-2)" "unprognostic (1.10e-1)" "unprognostic (1.47e-2)" "unprognostic (3.66e-3)" "unprognostic (6.66e-2)" "unprognostic (3.25e-1)" "unprognostic (1.58e-1)" 29.9 26.1 15.2 31.5 16.5 89.3 23.8 19.2 17.1 30.8 19.3 26.6 27.9 37.2 15.8 32.3 25.7 23.5 25.7 17.2 18.2 23.9 41.4 28.3 28.0 11.5 11.7 22.2 18.3 20.6 19.3 44.6 12.1 19.6 29.0 14.8 21.0 24.4 33.5 34.4 26.2 39.0 13.0 44.9 22.5 9.1 18.1 38.6 31.1 31.9 33.3 32.3 29.2 13.8 49.7 26.7 28.3 44.9 60.0 59.8 62.2 50.2 64.8 58.7 60.3 67.3 24.8 40.4 49.6 54.9 28.0 34.8 47.2 43.7 60.9 47.3 37.6 94.9 37.2 53.1 33.2 60.3 54.9 43.1 40.5 42.2 40.9 47.6 67.1 67.2 52.4 49.1 40.3 21.1 62.2 62.5 17.0 29.9 26.2 71.7 45.5 37.5 38.5 67.6 21.8 17.2 46.0 33.5 50.3 34.1 40.8 99.9 47.9 52.5 29.8 33.6 47.7 24.3 59.8 39.5 23.2 112.1 43.9 79.0 10.3 6.3 4.5 7.2 5.5 3.1 4.4 5.1 8.2 5.3 4.6 4.7 24.9 6.1 10.8 4.0 5.8 5.1 15.2 16.5 19.2 17.1 17.2 18.2 11.5 11.7 12.1 13.0 18.1 13.8 24.4 32.1 13.9 37.2 22.6 15.9 11.0 13.9 28.5 18.9 14.0 11.7 25.0 14.3 18.5 18.4 31.3 45.4 26.8 29.0 1.9 13.9 3.6 18.7 25.8 22.6 16.8 47.1 104.9 11.3 18.7 25.9 21.9 30.7 21.0 17.7 28.9 52.9 25.3 11.8 79.2 25.4 10.2 51.7 24.9 5.2 24.5 38.5 10.6 52.5 58.7 10.9 39.1 46.8 69.6 22.8 16.2 26.7 27.7 10.3 33.7 17.2 20.9 22.5 13.1 20.4 15.7 9.9 8.5 27.1 19.0 23.9 28.0 12.3 18.8 10.7 MAPK15 "ERK7, ERK8" ENSG00000181085 "Mitogen-activated protein kinase 15" Q8TD08 8 143716340-143722458 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 54.9;fallopian tube: 46.7" "Group enriched" "Detected in some" 5 "Endometrial ciliated cells: 62.5;Respiratory ciliated cells: 107.9" "Cancer enhanced" "Detected in many" "ovarian cancer: 18.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CAPAN-2: 9.6;HeLa: 20.7;MCF7: 14.3;T-47d: 14.0" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" HPA002704 Approved "Nucleoplasm,Cell Junctions,Cytosol" NA NA "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 20: HeLa - Mitochondria" "Cluster 49: Ciliated cells - Cilium organization" "Nucleoplasm, Cytosol" "Cell Junctions" "HPA002704: AB_1079307" "unprognostic (9.11e-2)" "unprognostic (1.38e-1)" "unprognostic (8.04e-3)" "unprognostic (2.94e-1)" "unprognostic (2.54e-2)" "unprognostic (1.14e-2)" "unprognostic (1.22e-1)" "unprognostic (6.09e-2)" "unprognostic (2.59e-2)" "unprognostic (1.48e-1)" "unprognostic (3.88e-1)" "unprognostic (9.51e-2)" "unprognostic (2.64e-2)" "unprognostic (1.54e-2)" "unprognostic (5.78e-1)" "unprognostic (6.35e-2)" "unprognostic (1.62e-2)" 1.6 0.1 3.3 0.2 4.0 0.0 1.9 1.7 8.1 6.9 54.9 1.0 0.3 2.5 2.4 1.1 46.7 0.2 0.6 5.0 3.6 10.5 0.3 12.1 0.4 10.2 14.5 0.9 4.4 9.4 6.9 0.3 7.0 2.2 0.2 0.0 2.2 1.7 0.1 4.0 0.8 0.4 6.6 0.7 0.8 11.4 6.4 1.1 16.1 0.0 0.2 0.5 2.1 3.0 0.4 0.6 1.9 0.0 0.0 0.0 0.7 1.8 0.0 0.0 0.0 0.5 9.6 0.0 1.6 0.0 0.0 5.5 0.1 0.2 0.0 1.0 2.0 0.0 20.7 0.0 0.2 0.0 0.1 0.1 0.0 0.0 0.0 1.2 0.0 0.2 3.4 0.0 0.0 14.3 0.0 0.0 2.5 1.2 1.2 0.0 3.7 0.5 1.0 1.6 3.6 5.1 0.0 3.3 0.0 0.2 14.0 0.0 0.1 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 4.0 1.7 8.1 5.0 3.6 10.2 14.5 7.0 6.6 6.4 3.0 0.1 0.0 6.4 0.0 0.1 0.4 0.3 5.7 0.0 0.0 1.0 1.3 0.7 0.0 11.8 0.0 0.0 0.0 0.0 0.1 0.0 1.1 13.8 62.5 0.5 0.3 0.0 0.0 0.2 0.0 0.7 0.8 0.0 1.7 0.0 0.6 0.0 0.0 0.1 0.0 0.0 0.6 16.2 0.0 0.0 11.5 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.3 0.0 1.4 107.9 0.0 0.0 0.4 2.2 2.3 0.9 0.0 0.3 0.1 0.2 0.1 0.3 0.1 MAPK3 "ERK1, p44erk1, p44mapk, PRKM3" ENSG00000102882 "Mitogen-activated protein kinase 3" P27361 16 30114105-30123506 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Apoptosis, Cell cycle, Host-virus interaction" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal enterocytes: 336.9;Early spermatids: 267.2;Proximal enterocytes: 235.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 5 "eosinophil: 49.1;neutrophil: 21.5" "Lineage enriched" "Detected in all" 7 "granulocytes: 49.1" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002683, HPA003995, HPA005700, HPA030069" Approved Supported Nucleoplasm NA NA 46000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 57: Non-specific - Angiogenesis" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "CAB002683: , HPA003995: AB_1078751, HPA005700: AB_1078750, HPA030069: AB_10602035" "unprognostic (5.03e-2)" "unprognostic (4.62e-2)" "unprognostic (3.46e-2)" "unprognostic (1.60e-1)" "unprognostic (4.70e-3)" "unprognostic (2.75e-1)" "prognostic unfavorable (1.11e-4)" "unprognostic (2.09e-2)" "unprognostic (3.59e-2)" "unprognostic (1.12e-1)" "unprognostic (1.55e-1)" "unprognostic (3.51e-2)" "unprognostic (8.78e-2)" "unprognostic (1.45e-1)" "unprognostic (3.01e-2)" "unprognostic (2.38e-1)" "unprognostic (1.19e-2)" 99.5 64.3 178.7 42.4 162.3 45.2 86.3 113.0 200.9 93.3 86.0 117.2 103.1 74.9 27.4 129.6 71.6 65.3 65.4 168.6 132.7 49.4 21.2 71.3 37.8 135.6 148.7 78.7 33.7 61.2 55.8 70.2 142.3 49.2 91.9 71.5 61.0 43.3 51.7 77.6 113.2 58.7 127.4 57.4 86.4 31.6 129.5 31.4 58.0 57.0 49.3 64.8 89.0 130.9 56.3 30.0 62.2 35.7 153.7 202.4 35.1 40.7 101.1 63.4 75.3 36.4 110.0 56.3 39.7 115.5 73.2 20.6 53.3 47.8 61.0 106.9 61.8 17.3 31.6 61.8 154.2 13.0 46.2 125.8 27.3 72.5 32.2 96.1 163.7 60.3 24.3 70.0 85.2 147.1 59.2 21.5 16.9 113.6 26.1 68.9 37.3 127.4 58.0 35.0 55.2 39.3 23.2 81.8 24.1 50.5 53.5 30.7 117.2 41.7 35.4 48.4 14.5 79.1 39.3 29.6 83.3 27.1 30.0 6.2 5.1 49.1 1.6 3.7 2.6 2.3 3.7 3.0 2.8 2.5 2.6 2.9 21.5 2.2 2.0 2.8 6.6 2.8 178.7 162.3 113.0 200.9 168.6 132.7 135.6 148.7 142.3 127.4 129.5 130.9 95.5 22.4 17.5 7.5 10.7 9.8 22.2 11.4 5.7 30.4 23.3 19.9 15.4 20.0 13.0 9.2 22.9 77.6 15.2 336.9 23.5 39.8 267.2 24.8 25.1 68.1 54.7 6.1 7.7 61.2 134.2 34.7 79.0 15.7 2.5 19.1 71.7 7.0 45.2 8.4 10.3 159.3 22.4 26.4 12.3 176.0 32.3 20.6 23.2 7.5 24.5 67.0 13.4 7.1 9.8 118.8 167.2 27.4 6.2 13.5 235.6 23.9 24.7 41.5 19.7 18.8 29.3 10.9 19.8 15.8 13.2 33.8 14.5 40.0 94.9 22.4 MAPK4 "Erk3-related, Erk4, PRKM4" ENSG00000141639 "Mitogen-activated protein kinase 4" P31152 18 50560087-50731826 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 81.9;parathyroid gland: 51.0" "Cell type enhanced" "Detected in some" "Astrocytes: 202.7;Excitatory neurons: 105.2;Inhibitory neurons: 58.5;Late spermatids: 66.4;Muller glia cells: 62.6" "Cancer enriched" "Detected in many" 4 "glioma: 15.2" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HAP1: 2.3;HeLa: 3.3;NTERA-2: 2.2;SCLC-21H: 11.6;SH-SY5Y: 2.8;SK-MEL-30: 1.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007461 Approved "Nucleoplasm,Golgi apparatus,Midbody" Yes NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoplasm, Golgi apparatus" Midbody "HPA007461: AB_1079308" "unprognostic (4.12e-2)" "unprognostic (3.24e-2)" "unprognostic (3.60e-1)" "unprognostic (1.42e-3)" "unprognostic (5.17e-2)" "unprognostic (1.84e-2)" "unprognostic (6.32e-2)" "unprognostic (2.08e-2)" "unprognostic (8.24e-2)" "unprognostic (1.61e-1)" "unprognostic (4.38e-3)" "unprognostic (2.16e-1)" "unprognostic (3.44e-7)" "unprognostic (1.96e-4)" "unprognostic (5.99e-4)" "unprognostic (2.31e-2)" "unprognostic (1.82e-1)" 0.9 26.8 56.5 0.2 79.9 0.0 0.8 56.4 46.0 1.5 28.0 6.8 0.6 0.8 3.1 2.3 1.5 1.8 22.1 41.6 57.5 3.3 4.5 2.3 0.0 65.4 70.0 2.9 1.4 51.0 17.8 2.6 56.7 5.0 0.8 22.6 0.9 9.8 1.5 1.3 1.6 1.8 48.8 0.1 2.1 2.4 81.9 7.3 6.2 1.5 0.0 4.6 1.3 38.7 0.0 0.0 1.0 0.6 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 0.0 0.0 0.0 1.1 1.1 3.3 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.7 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 11.6 2.8 0.0 0.8 1.9 0.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 56.5 79.9 56.4 46.0 41.6 57.5 65.4 70.0 56.7 48.8 81.9 38.7 0.4 9.6 0.0 202.7 0.0 0.0 0.4 0.0 0.0 11.4 0.9 1.1 22.9 1.5 0.0 0.0 0.0 4.6 0.0 0.0 5.9 0.9 30.1 0.0 0.0 0.3 0.0 0.0 105.2 0.0 0.3 1.0 0.0 0.0 0.0 0.7 0.0 1.0 0.4 5.0 58.5 0.0 0.0 0.0 0.0 66.4 0.9 0.1 0.0 7.5 0.0 62.6 0.0 18.6 1.9 0.4 0.0 1.5 0.0 0.7 0.0 0.2 0.0 1.0 0.0 1.0 0.7 0.8 0.6 0.0 0.0 1.8 0.0 0.4 0.0 0.1 MAPK6 "ERK3, HsT17250, p97MAPK, PRKM6" ENSG00000069956 "Mitogen-activated protein kinase 6" Q16659 15 51952106-52067375 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 218.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005184, HPA030262, HPA047825" Approved Supported Supported Cytosol NA NA "Cluster 15: NK-cells - Transcription" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 30: Epithelial cell lines - Translation" "Cluster 44: Endometrium - Transcription" Cytosol "CAB005184: AB_2140298, HPA030262: AB_10601868, HPA047825: " "unprognostic (6.61e-2)" "unprognostic (1.75e-2)" "unprognostic (5.05e-2)" "unprognostic (3.40e-3)" "unprognostic (2.72e-1)" "unprognostic (5.52e-2)" "unprognostic (6.13e-2)" "unprognostic (2.32e-3)" "unprognostic (3.99e-2)" "unprognostic (8.54e-2)" "unprognostic (3.68e-2)" "unprognostic (3.90e-2)" "unprognostic (3.27e-3)" "unprognostic (2.03e-1)" "unprognostic (1.72e-1)" "unprognostic (3.07e-2)" "unprognostic (2.31e-2)" 10.9 7.0 8.6 12.1 11.1 32.4 13.9 14.5 13.3 15.3 7.6 20.3 17.5 16.4 10.9 28.0 8.2 17.5 7.7 10.5 10.5 15.2 35.3 8.8 10.8 10.5 10.8 6.2 8.3 11.0 8.0 12.6 10.6 10.1 18.7 17.9 15.3 8.7 27.7 23.1 24.5 13.7 9.7 8.3 16.9 29.3 10.6 14.5 13.9 32.9 13.6 27.3 21.3 12.0 27.1 36.0 69.1 26.7 21.1 34.3 50.5 38.0 38.0 34.2 40.1 43.3 15.9 38.9 26.0 48.9 50.0 37.5 53.8 72.4 46.5 24.0 16.8 58.0 20.3 68.9 50.4 43.9 118.6 36.8 130.0 41.5 106.8 36.4 32.7 26.1 76.5 64.3 44.2 61.3 30.8 34.4 24.7 33.6 17.2 26.8 44.5 62.3 32.8 112.3 33.8 31.9 30.7 24.6 56.5 94.9 22.6 64.3 32.9 40.7 43.9 26.8 51.4 33.2 104.4 47.5 50.4 62.9 51.2 1.7 2.5 0.7 1.9 2.3 2.3 2.5 2.8 2.2 2.3 1.3 2.6 1.9 0.3 3.6 1.5 1.0 4.3 1.9 8.6 11.1 14.5 13.3 10.5 10.5 10.5 10.8 10.6 9.7 10.6 12.0 31.3 28.9 31.5 24.5 24.2 111.9 123.8 50.6 24.5 55.6 39.3 19.3 21.9 25.8 43.1 16.5 16.7 16.9 15.9 110.2 17.6 35.2 147.5 61.3 75.7 28.8 31.0 17.1 29.1 50.1 39.5 39.2 35.7 126.4 137.9 19.3 17.9 59.6 28.0 33.7 31.0 42.9 42.7 41.8 66.6 218.1 22.7 50.5 30.2 17.8 15.7 32.3 11.3 28.6 63.7 69.1 46.5 23.7 35.3 89.0 110.6 60.3 42.9 23.8 19.7 24.7 33.9 72.7 81.0 49.6 110.7 33.1 23.0 13.9 28.6 174.0 MAPK7 "BMK1, ERK5, PRKM7" ENSG00000166484 "Mitogen-activated protein kinase 7" Q13164 17 19377721-19383544 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Differentiation" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Spermatocytes: 33.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "ASC diff: 43.1;SuSa: 53.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB018561, HPA031031" Uncertain Enhanced Nucleoplasm,Cytosol NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 71: Testis - DNA repair" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 41: Macrophages - Immune response" Nucleoplasm Cytosol "CAB018561: AB_2140544, HPA031031: AB_2673706" "unprognostic (1.63e-1)" "unprognostic (2.75e-2)" "unprognostic (1.72e-1)" "unprognostic (2.90e-2)" "unprognostic (4.38e-2)" "unprognostic (1.20e-3)" "prognostic unfavorable (1.86e-4)" "unprognostic (5.67e-3)" "unprognostic (1.62e-2)" "unprognostic (1.16e-1)" "unprognostic (1.83e-2)" "unprognostic (4.75e-2)" "unprognostic (1.23e-2)" "unprognostic (1.90e-1)" "unprognostic (5.71e-1)" "unprognostic (1.55e-1)" "unprognostic (3.78e-2)" 8.3 13.7 4.0 4.0 4.4 5.2 7.7 4.0 5.9 14.3 4.4 10.6 5.5 11.1 3.3 16.3 8.7 4.5 6.2 3.9 4.5 7.7 3.9 8.7 3.7 5.3 6.1 12.5 3.4 2.9 6.1 6.7 4.4 8.9 3.5 2.2 6.7 6.1 5.0 12.5 7.3 6.7 3.3 9.4 6.7 11.8 5.0 3.5 7.4 3.4 3.6 10.1 15.2 4.1 6.9 11.0 9.9 7.7 43.1 17.2 10.4 9.0 8.3 13.0 12.4 12.2 1.4 4.1 7.3 16.5 10.4 8.2 10.4 9.4 7.8 7.2 8.3 1.9 8.4 5.4 21.2 1.9 7.8 21.6 6.2 18.2 7.2 12.0 9.5 7.5 3.7 1.4 13.2 4.8 13.0 7.4 10.7 8.4 6.7 8.6 12.9 3.0 5.4 3.7 4.4 12.3 9.7 1.0 5.0 53.7 6.1 3.1 6.0 14.6 10.8 15.5 6.7 2.6 4.0 1.2 16.5 1.6 9.2 0.8 3.4 10.7 3.7 6.5 2.0 1.8 1.8 3.2 2.3 1.0 1.6 2.0 1.1 4.9 6.0 1.4 1.0 3.1 4.0 4.4 4.0 5.9 3.9 4.5 5.3 6.1 4.4 3.3 5.0 4.1 10.7 6.4 3.3 2.6 7.8 5.5 6.1 9.5 13.6 2.4 5.8 4.6 5.3 2.8 5.6 5.5 2.1 5.7 6.7 16.2 5.9 8.1 8.7 3.0 7.9 8.5 10.7 1.7 2.0 6.2 8.0 9.6 12.2 5.2 2.5 7.7 7.5 1.1 7.7 0.0 2.1 6.9 10.2 6.9 6.1 5.7 11.5 14.4 3.6 6.5 3.4 13.1 17.5 1.0 2.0 8.0 20.8 11.7 9.3 6.3 9.0 3.5 3.2 2.1 26.3 8.4 11.1 33.2 16.4 9.8 4.3 5.1 6.2 7.7 6.7 5.3 MAPK8 "JNK, JNK1, PRKM8, SAPK1" ENSG00000107643 "Mitogen-activated protein kinase 8" P45983 10 48306639-48439360 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Biological rhythms" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 160.5;Excitatory neurons: 199.1;Inhibitory neurons: 218.2;Oligodendrocyte precursor cells: 233.7;Oligodendrocytes: 163.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004463, CAB069396" Approved NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 6: Brain - Smell perception" "Cluster 44: HDLM-2 - Immune response" "Cluster 29: Early spermatids - Spermatogenesis" "CAB004463: AB_675868, CAB069396: AB_1619977" "unprognostic (7.49e-2)" "unprognostic (1.47e-1)" "unprognostic (2.74e-2)" "unprognostic (1.46e-1)" "unprognostic (3.07e-2)" "unprognostic (1.60e-2)" "prognostic unfavorable (8.66e-4)" "unprognostic (4.23e-2)" "unprognostic (5.98e-2)" "unprognostic (4.31e-3)" "unprognostic (2.33e-1)" "unprognostic (6.06e-2)" "prognostic favorable (8.66e-4)" "unprognostic (1.58e-1)" "unprognostic (9.95e-2)" "unprognostic (1.85e-2)" "unprognostic (1.01e-3)" 7.2 6.7 11.3 7.0 12.6 11.3 13.8 18.3 12.8 8.8 4.5 9.0 10.4 11.0 7.7 9.4 7.5 9.2 7.2 12.5 9.4 13.6 15.6 6.7 7.8 11.6 9.7 11.0 7.5 8.6 7.9 8.3 13.1 8.3 9.9 21.9 9.6 8.2 11.7 6.5 11.2 9.6 8.8 6.7 8.1 13.1 10.9 13.8 14.1 9.6 9.6 8.3 7.0 12.8 29.2 7.2 21.8 12.8 11.3 10.4 16.5 37.9 23.6 20.0 17.8 7.7 19.2 10.9 10.5 21.3 10.7 13.1 10.2 15.2 31.2 45.4 16.5 15.9 6.8 12.7 16.0 24.2 13.2 9.5 18.5 14.4 21.8 12.5 22.0 22.4 25.1 14.5 13.2 8.6 22.1 15.4 14.4 10.0 4.7 17.8 25.8 12.6 17.1 11.1 38.3 34.8 13.5 11.9 16.1 14.8 12.4 11.4 16.7 14.4 31.9 14.6 30.4 6.2 18.0 16.4 14.3 24.9 8.7 0.0 1.1 1.4 1.1 1.1 2.1 0.6 1.7 1.3 1.0 0.8 1.7 1.0 0.8 1.3 1.4 1.8 1.1 1.0 11.3 12.6 18.3 12.8 12.5 9.4 11.6 9.7 13.1 8.8 10.9 12.8 21.2 3.2 17.1 145.3 21.9 44.7 50.6 19.3 20.5 56.2 34.4 17.7 10.0 22.8 18.0 7.3 31.3 15.5 22.3 19.1 11.7 28.9 160.5 25.7 21.9 22.0 31.0 12.4 199.1 25.3 7.4 21.8 16.3 42.9 12.0 25.8 10.4 22.3 9.8 70.7 218.2 16.5 28.5 11.0 34.9 99.2 14.6 18.4 21.4 93.7 25.4 18.9 11.3 233.7 163.0 35.9 22.5 10.1 31.2 39.3 25.4 24.3 16.6 34.6 6.6 23.0 24.5 28.1 28.1 17.5 36.7 15.7 21.6 41.0 11.9 45.5 MAPK9 "JNK2, p54a, PRKM9, SAPK" ENSG00000050748 "Mitogen-activated protein kinase 9" P45984 5 180233143-180292099 "Enzymes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Biological rhythms" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Inhibitory neurons: 64.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 6 "basophil: 16.3" "Lineage enriched" "Detected in all" 6 "granulocytes: 16.3" "Cell line enhanced" "Detected in all" "HDLM-2: 211.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008910, HPA072462" Enhanced Approved "Nuclear speckles,Plasma membrane,Cytosol" NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 39: Non-specific - Mitochondria" "Cluster 44: HDLM-2 - Immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Plasma membrane, Cytosol" "Nuclear speckles" "CAB008910: , HPA072462: " "unprognostic (5.04e-3)" "unprognostic (2.06e-2)" "prognostic favorable (1.11e-4)" "unprognostic (8.53e-2)" "unprognostic (1.75e-1)" "unprognostic (5.06e-3)" "unprognostic (6.83e-3)" "unprognostic (3.16e-1)" "unprognostic (4.93e-2)" "unprognostic (3.76e-1)" "unprognostic (5.97e-2)" "unprognostic (1.36e-1)" "unprognostic (1.50e-1)" "unprognostic (2.13e-1)" "unprognostic (2.29e-1)" "unprognostic (9.38e-3)" "unprognostic (2.40e-1)" 19.3 21.1 28.4 18.4 32.6 21.3 17.5 36.5 41.4 17.7 7.2 22.4 18.5 15.3 16.2 15.4 15.3 13.9 25.7 34.2 25.8 21.1 17.7 19.5 19.9 25.7 19.7 14.6 45.7 30.1 12.9 19.7 26.4 20.0 26.4 21.4 19.1 21.6 40.8 11.7 19.3 19.9 16.9 16.6 22.5 17.8 22.2 22.5 26.7 34.8 21.1 17.4 11.1 29.8 52.7 42.7 37.0 46.5 35.7 39.3 79.4 49.6 43.5 40.5 40.5 56.4 36.7 55.9 83.1 52.6 89.3 39.6 38.4 82.8 47.5 211.8 36.9 23.2 46.8 40.3 27.1 49.0 39.2 29.3 36.5 39.5 38.0 42.5 48.9 43.0 26.2 39.5 55.9 68.9 49.2 20.4 25.8 64.8 25.0 46.9 62.7 26.9 30.8 49.7 42.5 29.9 58.2 55.8 40.4 45.8 56.9 41.7 35.5 48.3 49.2 69.3 75.2 28.2 35.6 37.9 51.5 44.8 32.9 16.3 0.5 2.2 1.6 1.1 1.6 0.8 1.2 1.4 0.8 1.3 0.8 0.9 0.7 1.2 2.3 1.2 2.7 0.3 28.4 32.6 36.5 41.4 34.2 25.8 25.7 19.7 26.4 16.9 22.2 29.8 20.5 32.1 14.4 26.1 10.5 10.1 7.0 6.5 9.1 21.9 16.8 12.2 27.6 12.8 8.5 9.2 16.7 15.3 20.5 20.7 5.9 8.0 1.2 17.6 14.2 12.2 16.7 9.5 62.5 16.0 23.3 11.1 15.8 18.6 11.4 14.5 12.5 16.7 11.7 13.5 64.3 17.9 4.1 24.2 20.5 3.1 10.5 15.0 5.4 31.9 13.9 11.4 15.5 25.1 32.9 13.1 12.3 13.5 15.6 10.2 13.4 11.0 6.9 14.8 13.1 13.5 13.7 17.0 17.1 9.4 11.4 17.8 14.7 8.2 15.4 8.8 MAPKAPK2 MK2 ENSG00000162889 "MAPK activated protein kinase 2" P49137 1 206684905-206734281 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted membrane proteins" "DNA damage" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "dendritic cells: 185.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 6 "plasmacytoid DC: 21.9" "Lineage enriched" "Detected in all" 6 "dendritic cells: 21.9" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010297, HPA045556, HPA063708, HPA064435" Approved Supported Nucleoplasm,Centrosome NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 29: U-266 - Adaptive immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Nucleoplasm Centrosome "CAB010297: AB_2250405, HPA045556: AB_2679367, HPA063708: AB_2685100, HPA064435: AB_2685263" "unprognostic (7.93e-2)" "unprognostic (1.83e-1)" "unprognostic (5.27e-2)" "unprognostic (5.12e-2)" "unprognostic (1.80e-1)" "unprognostic (1.32e-2)" "prognostic unfavorable (1.93e-4)" "unprognostic (9.85e-2)" "unprognostic (1.68e-1)" "unprognostic (2.00e-1)" "unprognostic (1.01e-2)" "unprognostic (1.35e-1)" "prognostic unfavorable (4.58e-6)" "unprognostic (2.12e-1)" "unprognostic (1.37e-1)" "unprognostic (6.96e-2)" "unprognostic (3.29e-2)" 61.9 80.4 34.8 56.2 39.1 174.6 50.5 36.9 33.9 47.3 38.7 50.3 65.5 53.3 24.1 55.8 50.8 52.5 190.1 30.8 36.6 79.5 66.8 79.3 57.8 53.1 42.1 44.8 53.8 38.0 63.3 25.7 43.9 42.8 35.3 17.6 54.9 33.1 196.7 54.4 61.7 45.4 40.1 78.3 68.2 46.9 45.2 45.6 47.7 94.3 54.4 63.5 46.6 38.6 85.4 33.1 44.8 50.6 128.4 75.0 55.1 57.3 130.0 86.0 80.7 63.8 40.4 40.6 38.8 116.9 54.1 63.0 33.8 61.7 61.4 46.5 25.4 69.1 41.7 41.3 99.0 102.3 219.5 104.1 77.3 82.8 91.3 71.8 71.7 54.1 79.7 180.2 70.5 105.2 41.2 73.3 51.5 29.9 45.1 103.7 94.0 13.5 64.9 51.5 35.7 45.7 68.0 114.2 83.1 83.0 55.4 97.2 68.7 77.6 64.7 91.0 79.7 232.0 220.6 33.2 87.8 60.9 26.0 1.6 0.8 1.8 1.8 1.4 1.6 1.1 1.3 1.7 0.7 1.2 0.6 1.2 3.7 2.6 1.3 21.9 1.8 0.7 34.8 39.1 36.9 33.9 30.8 36.6 53.1 42.1 43.9 40.1 45.2 38.6 49.2 54.5 49.9 15.7 27.9 85.4 52.3 18.3 20.5 12.4 61.4 37.8 102.5 37.1 26.8 31.3 20.9 6.4 185.9 51.9 15.6 30.6 76.2 32.2 40.9 43.7 61.7 15.4 4.7 58.5 9.2 33.4 32.1 46.6 34.9 24.8 19.2 40.0 24.8 0.0 10.6 38.1 16.2 34.6 82.7 36.1 22.7 60.9 33.8 13.1 23.7 21.7 74.2 8.5 17.4 61.6 34.4 17.3 69.6 67.3 22.2 25.0 14.4 16.0 26.3 36.9 48.5 13.7 10.3 31.5 72.0 16.6 46.0 19.2 30.5 75.0 MAPKAPK3 "3pK, MAPKAP3, MK-3, MK3" ENSG00000114738 "MAPK activated protein kinase 3" Q16644 3 50611520-50649291 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 4 "bone marrow: 106.5;heart muscle: 256.3;skeletal muscle: 224.2;tongue: 284.3" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 226.6;Hofbauer cells: 102.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Group enriched" "Detected in all" 5 "dendritic cells: 142.8;granulocytes: 126.3;monocytes: 341.5" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA058275 Supported Nucleoplasm NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 8: Non-specific - Mitochondria" "Cluster 32: U-937 - Innate immune response" "Cluster 54: Cardiomyocytes - Muscle contraction" Nucleoplasm "HPA058275: AB_2683663" "unprognostic (6.46e-3)" "unprognostic (1.84e-1)" "prognostic favorable (8.08e-5)" "unprognostic (1.17e-1)" "unprognostic (1.93e-1)" "unprognostic (9.96e-2)" "unprognostic (8.77e-3)" "unprognostic (7.68e-3)" "unprognostic (1.11e-1)" "unprognostic (5.87e-2)" "unprognostic (2.19e-3)" "unprognostic (1.01e-1)" "prognostic favorable (1.90e-8)" "unprognostic (2.15e-2)" "unprognostic (1.22e-1)" "unprognostic (1.86e-1)" "unprognostic (1.69e-1)" 15.3 43.3 18.0 29.8 19.6 106.5 15.8 19.2 19.2 15.0 21.3 19.7 30.2 11.3 10.3 49.6 15.1 12.1 256.3 18.0 19.7 40.0 18.7 28.2 21.7 23.6 20.5 14.2 36.2 47.2 23.5 13.9 22.5 18.4 20.0 4.7 27.7 12.6 224.2 53.4 24.2 15.9 21.6 25.3 27.6 9.2 21.1 42.0 41.2 284.3 24.2 20.3 22.2 21.6 99.6 30.3 12.4 35.9 18.4 45.7 27.9 23.8 33.7 35.7 30.3 47.1 90.2 39.8 23.5 79.5 88.5 34.6 85.9 92.7 31.9 88.3 22.3 209.5 40.6 43.5 36.8 152.1 106.4 36.9 57.0 83.1 112.2 35.6 31.9 70.2 59.7 25.4 76.1 40.5 65.3 153.3 46.4 34.6 127.0 28.5 29.9 60.1 165.5 56.2 23.0 16.5 21.3 58.9 27.7 20.6 37.8 93.4 23.8 28.1 64.5 146.4 59.5 17.2 33.7 33.1 148.3 234.7 11.8 45.3 169.5 126.3 27.6 271.6 27.3 15.1 30.9 32.1 142.8 8.8 23.9 27.8 104.4 42.1 341.5 91.2 28.0 132.6 18.0 19.6 19.2 19.2 18.0 19.7 23.6 20.5 22.5 21.6 21.1 21.6 3.5 9.6 14.0 8.5 8.6 11.3 26.9 14.0 19.4 1.1 15.3 12.3 226.6 15.7 10.4 11.0 0.0 6.0 38.1 16.2 64.6 45.6 34.5 3.4 2.7 7.1 6.0 19.1 0.3 30.4 7.4 14.9 11.7 5.4 36.2 8.3 5.3 14.2 102.1 0.0 0.7 15.4 10.2 68.0 23.9 86.2 7.2 59.4 7.2 0.0 76.6 17.1 41.2 0.5 2.0 76.2 15.6 3.4 12.7 30.9 30.7 35.4 5.7 2.3 26.3 9.7 12.0 4.1 4.6 34.2 20.2 5.1 24.3 22.0 28.2 33.5 MAPKAPK5 "MK5, PRAK" ENSG00000089022 "MAPK activated protein kinase 5" Q8IW41 12 111842228-111902222 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004546, HPA015515" Supported Supported Nucleoplasm,Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoplasm, Cytosol" "CAB004546: AB_627910, HPA015515: AB_1853569" "unprognostic (6.45e-2)" "unprognostic (7.29e-2)" "unprognostic (1.27e-3)" "unprognostic (1.09e-2)" "unprognostic (5.52e-2)" "unprognostic (3.76e-2)" "prognostic unfavorable (2.98e-8)" "unprognostic (1.88e-1)" "unprognostic (3.09e-2)" "unprognostic (1.22e-1)" "unprognostic (1.75e-1)" "unprognostic (1.25e-2)" "unprognostic (3.20e-1)" "unprognostic (6.03e-2)" "unprognostic (3.39e-2)" "unprognostic (9.41e-2)" "unprognostic (3.25e-2)" 18.1 20.8 12.6 17.9 14.4 27.1 20.4 14.9 15.0 15.2 15.7 28.2 25.5 15.7 20.7 17.2 16.1 12.2 16.7 15.3 14.3 20.3 19.4 17.5 20.7 12.3 12.4 18.1 20.4 21.4 11.6 20.3 11.8 17.0 30.7 27.2 17.4 15.6 30.4 20.1 28.2 18.9 11.3 15.6 18.0 15.9 12.9 23.2 19.3 25.3 19.3 18.5 14.4 13.8 32.4 42.1 40.0 33.7 28.2 28.4 60.6 31.7 38.1 47.7 32.7 54.8 25.9 48.6 22.9 37.7 28.4 31.6 53.1 33.2 44.4 32.6 29.0 43.4 29.5 44.2 34.1 55.1 29.4 30.2 46.7 45.6 53.7 36.0 35.6 43.4 61.0 18.7 35.3 36.4 55.2 86.6 56.9 79.1 29.4 53.7 29.1 46.9 37.9 46.2 49.0 41.4 36.1 60.5 46.3 36.2 49.1 62.0 31.2 26.8 27.2 27.9 40.4 37.8 50.1 57.4 32.7 39.4 38.9 1.1 3.3 2.3 4.2 2.4 2.2 3.5 2.7 3.0 2.2 3.1 4.2 3.1 1.6 2.9 8.8 2.6 4.8 1.8 12.6 14.4 14.9 15.0 15.3 14.3 12.3 12.4 11.8 11.3 12.9 13.8 16.9 3.2 23.1 12.1 22.3 20.5 22.3 12.5 21.1 47.0 18.3 14.0 20.1 22.8 15.4 3.7 41.7 29.9 32.4 34.1 13.7 28.2 17.2 14.2 17.3 16.0 36.6 15.8 24.6 29.6 33.3 19.4 20.9 15.2 2.5 22.3 14.6 13.4 19.9 23.5 22.3 47.3 14.2 21.2 17.7 7.3 15.5 15.0 8.8 14.0 27.8 19.6 25.7 15.6 21.8 36.3 27.4 17.7 21.6 37.5 63.6 21.8 12.0 36.4 19.7 22.6 19.8 30.7 40.3 23.6 21.3 30.1 22.2 22.5 32.3 32.3 MARCHF1 "FLJ20668, MARCH-I, MARCH1, RNF171" ENSG00000145416 "Membrane associated ring-CH-type finger 1" Q8TCQ1 4 163524298-164384050 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Immunity, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 31.6;retina: 27.5" "Group enriched" "Detected in some" 4 "B-cells: 21.4;Hofbauer cells: 46.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 94 "classical monocyte: 41.8;eosinophil: 25.5;intermediate monocyte: 41.0;memory B-cell: 42.3;myeloid DC: 44.2;naive B-cell: 35.8;non-classical monocyte: 45.4;plasmacytoid DC: 16.5" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "Daudi: 7.1;U-266/70: 7.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA014600, HPA048024" Uncertain Supported "Endoplasmic reticulum,Golgi apparatus,Vesicles" NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 16: Immune cells - Immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 41: Macrophages - Immune response" Vesicles "Endoplasmic reticulum, Golgi apparatus" "HPA014600: AB_1853573, HPA048024: " "unprognostic (7.29e-2)" "unprognostic (5.82e-2)" "unprognostic (1.48e-1)" "unprognostic (9.09e-2)" "unprognostic (8.25e-2)" "unprognostic (2.98e-2)" "unprognostic (4.79e-3)" "unprognostic (9.00e-2)" "unprognostic (3.00e-2)" "unprognostic (2.18e-1)" "unprognostic (1.13e-1)" "unprognostic (2.20e-1)" "unprognostic (1.24e-1)" "unprognostic (7.00e-2)" "unprognostic (2.48e-2)" "unprognostic (2.70e-1)" "unprognostic (2.91e-2)" 6.4 3.5 7.8 21.5 8.1 3.9 2.7 3.6 7.7 3.1 1.8 3.5 3.9 2.5 0.7 3.0 2.8 5.3 1.7 6.6 10.1 1.8 4.1 8.0 31.6 8.0 8.2 2.7 2.8 0.8 2.5 9.9 6.9 2.3 4.5 27.5 3.2 1.2 1.0 4.5 7.0 6.2 7.0 25.8 3.9 1.7 12.1 5.6 2.1 1.0 25.5 7.7 2.9 14.4 0.6 0.5 2.1 1.2 0.0 0.0 1.3 0.9 0.0 0.0 0.0 1.2 2.4 7.1 2.5 0.0 0.2 1.0 0.0 0.0 0.0 0.8 0.7 5.0 3.0 0.5 0.0 3.1 1.6 0.0 0.0 0.0 0.1 2.8 0.0 1.3 1.9 3.6 2.4 0.7 1.8 1.9 2.6 0.2 0.9 2.0 0.3 0.5 0.1 1.1 1.0 0.9 0.6 1.0 0.4 1.4 2.9 0.5 2.3 0.8 1.4 0.5 1.7 7.0 2.5 1.9 0.9 1.5 1.1 0.0 41.8 25.5 0.1 41.0 0.0 42.3 0.1 0.0 44.2 35.8 0.0 0.0 0.3 0.3 45.4 16.5 0.0 18.4 7.8 8.1 3.6 7.7 6.6 10.1 8.0 8.2 6.9 7.0 12.1 14.4 0.1 0.0 0.0 0.0 21.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.9 0.0 0.0 0.0 0.0 0.3 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.5 0.2 0.0 0.0 0.0 0.0 0.0 0.0 46.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.8 0.1 0.0 0.0 0.0 MARCHF10 "FLJ35757, MARCH-X, MARCH10, RNF190" ENSG00000173838 "Membrane associated ring-CH-type finger 10" Q8NA82 17 62701314-62808344 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 11 "testis: 137.6" "Not detected" "Not detected" "Low cancer specificity" "Detected in single" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 2.5;EFO-21: 4.7;HSkMC: 2.1;SCLC-21H: 8.3" "Low region specificity" "Detected in single" "Low region specificity" "Detected in some" HPA023322 Enhanced Approved "Plasma membrane,Cytosol" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 49: Ciliated cells - Cilium organization" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 24: Non-specific - Transcription regulation" "Plasma membrane, Cytosol" "HPA023322: AB_1856351" "unprognostic (2.79e-2)" "unprognostic (2.32e-1)" "unprognostic (9.60e-3)" "unprognostic (6.95e-2)" "unprognostic (1.21e-1)" "unprognostic (1.21e-1)" "unprognostic (1.03e-2)" "unprognostic (1.67e-1)" "unprognostic (1.39e-1)" "unprognostic (7.99e-4)" "unprognostic (3.16e-1)" "unprognostic (2.85e-3)" "unprognostic (1.38e-1)" "unprognostic (4.83e-2)" "unprognostic (9.37e-3)" "unprognostic (2.66e-1)" 0.1 0.2 1.3 0.2 1.6 0.0 0.1 1.2 0.9 1.4 10.5 1.1 0.0 0.4 7.5 0.1 12.8 0.1 0.1 1.1 1.3 1.5 0.0 2.7 0.0 3.6 5.0 0.1 0.2 0.3 12.7 0.0 2.6 0.6 0.0 0.1 0.3 0.1 0.0 0.2 0.4 0.0 3.6 0.1 0.4 137.6 1.3 0.2 0.1 0.0 0.0 0.1 0.2 2.0 0.1 0.0 0.1 0.0 0.0 0.1 2.5 1.1 0.1 0.8 0.2 0.0 0.0 0.0 4.7 0.3 0.1 0.0 0.0 0.2 0.9 0.0 0.0 0.8 0.6 0.0 1.0 0.0 0.0 2.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.6 1.0 0.1 0.0 0.2 0.0 0.1 0.0 0.0 0.1 0.7 0.0 8.3 0.0 0.0 0.5 0.0 0.3 0.1 0.0 0.0 0.0 0.4 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.9 0.0 0.3 0.0 0.1 0.1 0.2 0.0 0.1 0.4 0.0 0.1 0.0 0.0 0.2 0.1 1.3 1.6 1.2 0.9 1.1 1.3 3.6 5.0 2.6 3.6 1.3 2.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 MARCHF11 "MARCH-XI, MARCH11, RNF226" ENSG00000183654 "Membrane associated ring-CH-type finger 11" A6NNE9 5 16067139-16180762 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 8 "testis: 82.4" "Cell type enriched" "Detected in single" 30 "Cardiomyocytes: 6.1" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 11 "SH-SY5Y: 83.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 54: Cardiomyocytes - Muscle contraction" "unprognostic (9.91e-3)" "unprognostic (1.08e-1)" "unprognostic (2.98e-1)" "unprognostic (1.50e-1)" "unprognostic (1.54e-1)" "unprognostic (1.52e-1)" "unprognostic (3.55e-2)" 0.1 0.7 4.7 0.0 4.6 0.0 0.3 5.0 6.7 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.9 5.7 6.7 0.2 0.1 0.0 0.0 5.7 4.7 0.3 1.3 0.0 9.9 0.0 5.0 0.3 0.0 3.6 1.0 0.0 0.0 0.1 0.0 0.0 3.8 0.0 0.1 82.4 4.8 0.0 0.0 0.0 0.0 0.0 0.1 4.7 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.0 83.8 0.0 0.0 0.0 7.5 0.0 0.0 0.0 1.5 0.3 0.0 0.0 1.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.7 4.6 5.0 6.7 5.7 6.7 5.7 4.7 5.0 3.8 4.8 4.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 MARCHF2 "HSPC240, MARCH-II, MARCH2, RNF172" ENSG00000099785 "Membrane associated ring-CH-type finger 2" Q9P0N8 19 8413270-8439017 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Endocytosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in some" "Adipocytes: 23.1;Cardiomyocytes: 42.3;Extravillous trophoblasts: 11.6;Hofbauer cells: 66.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA014063 Approved Supported "Endoplasmic reticulum,Cytosol" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 3: HMC-1 - Innate immune response" "Cluster 24: Non-specific - Transcription regulation" "Endoplasmic reticulum" Cytosol "HPA014063: AB_1853576" "unprognostic (1.15e-2)" "unprognostic (4.01e-3)" "prognostic unfavorable (6.48e-4)" "prognostic favorable (1.05e-5)" "unprognostic (3.00e-1)" "prognostic favorable (8.29e-4)" "unprognostic (3.43e-2)" "unprognostic (6.95e-2)" "unprognostic (3.06e-3)" "unprognostic (2.32e-1)" "prognostic favorable (6.21e-4)" "unprognostic (2.01e-1)" "unprognostic (3.52e-1)" "unprognostic (1.01e-1)" "unprognostic (3.16e-1)" "unprognostic (9.91e-2)" "unprognostic (1.80e-2)" 65.7 33.0 102.2 20.3 101.5 29.4 49.8 99.5 106.6 24.2 66.4 96.2 15.7 34.4 53.9 32.4 27.1 15.3 101.1 90.9 94.3 35.6 59.1 41.9 19.5 113.7 102.5 15.8 19.2 15.3 30.5 19.8 106.0 40.8 14.0 9.1 25.5 28.8 89.5 34.5 31.4 30.1 109.2 51.2 32.9 18.9 105.1 14.2 47.9 48.6 14.5 49.8 26.1 96.7 11.4 14.2 6.3 29.5 37.9 12.6 10.7 12.3 14.7 9.5 9.8 7.0 5.5 4.4 34.8 26.7 12.6 8.1 8.2 17.5 7.3 22.7 20.3 34.2 6.6 15.9 20.5 5.0 49.6 14.7 20.1 9.2 8.1 13.9 38.2 17.8 4.9 24.5 7.5 21.5 7.0 16.7 13.3 14.0 34.2 11.0 2.0 11.4 22.4 13.9 3.1 17.7 0.8 12.9 24.2 21.5 10.2 10.8 38.9 13.3 8.4 44.5 10.4 21.7 28.2 5.0 21.6 10.2 10.7 52.6 18.5 31.3 10.6 28.6 10.8 7.2 10.6 8.6 13.1 7.3 7.2 9.6 23.4 7.9 25.7 51.8 14.9 17.4 102.2 101.5 99.5 106.6 90.9 94.3 113.7 102.5 106.0 109.2 105.1 96.7 23.1 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 42.3 0.0 0.0 0.0 0.0 8.1 9.9 0.0 0.0 0.0 0.0 0.0 0.0 5.0 0.0 0.0 0.0 0.0 11.6 7.7 0.0 0.0 0.0 0.0 0.0 0.0 66.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.6 0.0 0.0 0.0 0.0 5.7 1.5 0.0 0.0 0.0 MARCHF3 "MARCH-III, MARCH3, MGC48332, RNF173" ENSG00000173926 "Membrane associated ring-CH-type finger 3" Q86UD3 5 126867714-127030558 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Endocytosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in some" 4 "Cytotrophoblasts: 43.8;Syncytiotrophoblasts: 98.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "memory B-cell: 10.5;naive B-cell: 12.1" "Lineage enriched" "Detected in many" 4 "B-cells: 12.1" "Cell line enhanced" "Detected in many" "hTEC/SVTERT24-B: 40.4;HUVEC TERT2: 27.4;TIME: 33.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA043406 Uncertain Supported Vesicles NA NA "Cluster 37: B-cells - Transcription" "Cluster 77: Retina - Visual perception" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" Vesicles "HPA043406: AB_10793947" "unprognostic (5.96e-3)" "unprognostic (1.46e-2)" "unprognostic (1.91e-2)" "unprognostic (4.21e-2)" "unprognostic (9.00e-3)" "unprognostic (1.17e-2)" "unprognostic (7.75e-3)" "unprognostic (9.41e-2)" "unprognostic (8.93e-2)" "unprognostic (2.05e-3)" "unprognostic (3.15e-2)" "unprognostic (1.82e-1)" "unprognostic (5.60e-6)" "unprognostic (7.74e-2)" "unprognostic (7.64e-2)" "unprognostic (1.05e-1)" "unprognostic (3.64e-1)" 5.6 2.8 6.1 2.9 5.6 3.7 2.6 5.3 4.1 0.9 1.9 5.3 0.9 1.4 0.0 1.4 1.5 5.2 7.8 3.9 5.7 0.8 0.7 2.4 2.5 11.5 7.1 1.1 2.4 0.3 2.4 1.7 7.9 0.6 5.6 7.4 4.6 0.2 6.5 5.8 2.4 2.9 8.3 1.6 2.4 5.6 7.8 1.3 1.4 3.3 2.1 7.6 0.7 8.5 0.4 1.8 3.9 2.1 3.4 3.2 1.2 14.2 5.9 11.1 16.3 1.9 0.8 3.8 1.3 1.9 2.4 1.1 4.9 2.5 15.3 0.8 4.7 12.2 3.2 1.9 5.6 5.0 3.0 2.4 0.7 40.4 4.8 2.6 27.4 0.6 5.1 0.7 9.3 1.3 0.5 2.3 3.3 3.0 4.6 1.5 15.5 1.2 0.9 2.0 1.3 0.9 3.3 0.5 1.6 1.9 2.9 5.0 33.5 2.2 1.8 12.6 1.6 1.9 2.3 2.3 8.3 3.8 2.0 0.0 0.2 2.8 0.5 0.4 0.1 10.5 0.6 0.3 0.1 12.1 2.3 0.5 0.8 2.3 0.3 0.7 2.9 0.8 6.1 5.6 5.3 4.1 3.9 5.7 11.5 7.1 7.9 8.3 7.8 8.5 3.8 0.0 0.0 0.0 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.4 0.0 0.0 0.0 0.0 43.8 5.7 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 3.2 5.8 0.0 0.0 0.0 0.0 0.0 0.0 8.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 98.6 0.6 0.0 0.0 0.0 MARCHF4 "KIAA1399, MARCH-IV, MARCH4, RNF174" ENSG00000144583 "Membrane associated ring-CH-type finger 4" Q9P2E8 2 216257865-216372483 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Group enriched" "Detected in some" 4 "brain: 4.4;pituitary gland: 6.2" "Not detected" "Not detected" "Cancer enhanced" "Detected in some" "pancreatic cancer: 1.2" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ: 69.0;fHDF/TERT166: 43.8;TIME: 32.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA014348 Approved NA NA "Cluster 65: Brain - Ion transport" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 43: Cardiomyocytes - Nuclear processes" "HPA014348: AB_1853578" "unprognostic (4.84e-2)" "unprognostic (1.02e-4)" "unprognostic (1.63e-1)" "unprognostic (5.42e-2)" "unprognostic (3.31e-2)" "unprognostic (1.88e-1)" "unprognostic (1.38e-1)" "unprognostic (1.26e-2)" "unprognostic (1.24e-2)" "unprognostic (6.49e-2)" "unprognostic (5.55e-3)" "unprognostic (1.07e-1)" "unprognostic (6.81e-5)" "unprognostic (4.82e-2)" "unprognostic (2.06e-1)" "unprognostic (1.23e-1)" "unprognostic (1.09e-3)" 0.0 0.7 2.6 0.0 3.9 0.0 0.0 0.0 4.4 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.6 0.0 0.0 3.1 2.2 0.0 0.0 0.0 0.0 0.5 4.1 0.0 0.4 0.0 6.2 0.6 1.1 0.0 0.2 0.6 0.0 0.0 0.0 0.1 0.2 0.0 2.7 0.0 1.3 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 12.5 2.5 0.0 0.0 0.2 1.6 0.0 69.0 23.2 14.5 5.1 0.1 1.0 0.0 10.5 43.8 24.2 0.1 0.0 26.7 14.1 0.0 0.0 5.1 0.0 0.0 3.4 0.0 0.0 0.1 0.0 13.3 19.6 9.3 19.0 0.0 0.0 0.0 22.6 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 11.4 1.9 0.1 0.0 0.0 2.2 0.0 0.0 32.7 22.7 23.9 0.1 18.6 0.0 0.0 0.0 5.2 0.0 16.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 3.9 0.0 4.4 3.1 2.2 0.5 4.1 1.1 2.7 1.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 MARCHF5 "FLJ20445, MARCH-V, MARCH5, MITOL, RNF153" ENSG00000198060 "Membrane associated ring-CH-type finger 5" Q9NX47 10 92291167-92353964 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in some" "Adipocytes: 23.8;Cardiomyocytes: 28.6;Cytotrophoblasts: 39.2;Extravillous trophoblasts: 44.0;Hofbauer cells: 34.9;Syncytiotrophoblasts: 65.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA056596 Supported Mitochondria NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 24: Non-specific - Transcription regulation" Mitochondria "HPA056596: AB_2683181" "unprognostic (4.00e-2)" "unprognostic (5.15e-2)" "unprognostic (1.25e-1)" "unprognostic (4.10e-2)" "unprognostic (5.47e-3)" "unprognostic (2.33e-3)" "unprognostic (4.43e-1)" "unprognostic (1.63e-1)" "unprognostic (1.24e-2)" "unprognostic (9.77e-2)" "unprognostic (5.50e-3)" "unprognostic (4.02e-3)" "unprognostic (6.14e-2)" "unprognostic (2.87e-1)" "unprognostic (1.62e-1)" "unprognostic (4.53e-1)" "unprognostic (2.85e-2)" 13.6 14.0 9.1 7.7 9.6 17.3 15.0 9.1 11.9 12.2 10.4 9.8 11.3 13.3 12.6 19.3 10.1 10.7 12.8 9.6 9.4 15.1 20.1 10.4 9.0 9.0 9.4 14.0 9.2 12.5 7.0 7.8 8.8 15.1 10.1 8.8 13.7 7.8 18.2 9.8 11.6 10.7 9.6 8.9 10.5 8.8 9.3 12.5 17.2 16.1 9.8 10.7 12.2 9.7 28.0 14.8 28.7 33.1 19.2 19.8 14.8 24.5 26.7 29.8 30.4 10.0 19.6 16.2 16.5 24.1 13.0 22.4 20.3 20.5 42.5 12.3 23.9 13.1 13.6 23.7 23.2 21.1 12.4 20.4 27.0 19.7 40.9 39.6 26.6 17.0 14.5 19.7 24.2 17.7 18.7 24.1 6.7 18.1 22.1 20.0 29.4 9.8 30.8 17.8 13.3 24.5 21.3 15.5 26.7 13.7 27.1 16.1 26.0 13.9 15.3 15.3 34.0 19.9 16.2 14.2 12.7 28.7 9.5 4.2 6.0 7.0 5.1 7.5 5.2 5.2 5.7 5.5 6.9 4.5 5.7 5.5 12.2 5.0 6.7 4.6 5.9 5.0 9.1 9.6 9.1 11.9 9.6 9.4 9.0 9.4 8.8 9.6 9.3 9.7 23.8 0.0 0.0 0.0 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 28.6 0.0 0.0 0.0 0.0 39.2 12.9 0.0 0.0 0.0 0.0 0.0 0.0 3.5 0.0 0.0 0.0 0.0 44.0 9.3 0.0 0.0 0.0 0.0 0.0 0.0 34.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.4 0.0 0.0 0.0 0.0 65.3 2.8 0.0 0.0 0.0 MARCHF6 "MARCH-VI, MARCH6, RNF176, TEB4" ENSG00000145495 "Membrane associated ring-CH-type finger 6" O60337 5 10353695-10440388 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase Epilepsy "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in some" "Adipocytes: 38.5;Cardiomyocytes: 102.5;Cytotrophoblasts: 54.4;dendritic cells: 25.8;Extravillous trophoblasts: 30.0;Hofbauer cells: 36.4;Syncytiotrophoblasts: 81.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040841, HPA063246" Approved Supported "Endoplasmic reticulum" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 3: T-cells - Adaptive immune response" "Cluster 20: HeLa - Mitochondria" "Cluster 24: Non-specific - Transcription regulation" "Endoplasmic reticulum" "HPA040841: AB_2677162, HPA063246: AB_2684970" "unprognostic (3.31e-2)" "unprognostic (2.04e-1)" "unprognostic (2.85e-2)" "unprognostic (3.80e-3)" "unprognostic (4.00e-1)" "unprognostic (2.26e-1)" "unprognostic (3.06e-2)" "unprognostic (9.52e-3)" "unprognostic (1.53e-1)" "unprognostic (1.05e-3)" "unprognostic (3.94e-2)" "unprognostic (5.58e-2)" "unprognostic (5.08e-3)" "unprognostic (1.61e-1)" "unprognostic (2.88e-1)" "unprognostic (3.57e-1)" "unprognostic (8.50e-3)" 22.1 25.5 16.1 20.3 23.7 76.5 25.9 28.3 20.7 20.1 2.9 26.9 32.8 22.7 25.5 20.9 24.9 24.5 30.8 22.0 30.4 34.1 32.5 25.1 24.7 13.7 17.5 36.0 39.3 62.4 20.8 22.8 16.9 22.7 19.8 36.6 25.6 23.8 48.4 24.8 30.3 18.9 13.8 28.2 30.2 29.9 27.9 32.3 29.3 51.8 23.3 23.7 18.6 33.5 37.4 55.1 90.1 69.9 50.6 40.4 73.7 57.7 53.7 48.9 61.8 52.8 97.0 39.4 85.4 54.4 67.2 52.3 48.2 37.7 65.4 82.9 43.0 50.7 179.7 36.2 35.6 61.4 54.6 47.4 40.6 49.0 53.1 50.0 45.8 41.4 62.1 85.1 45.0 42.4 33.1 47.2 32.8 29.9 38.5 50.9 37.6 57.0 38.0 72.4 38.7 56.0 107.2 57.9 38.4 41.3 48.2 32.5 44.8 58.4 56.8 29.1 43.7 59.3 94.1 55.7 43.1 40.7 42.8 15.6 7.4 12.6 11.2 8.4 12.8 11.7 10.8 11.0 6.3 9.6 12.5 12.4 12.1 9.1 11.1 5.0 10.4 9.1 16.1 23.7 28.3 20.7 22.0 30.4 13.7 17.5 16.9 13.8 27.9 33.5 38.5 0.0 0.0 0.0 13.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 102.5 0.0 0.0 0.0 0.0 54.4 25.8 0.0 0.0 0.0 0.0 0.0 0.0 10.4 0.0 0.0 0.0 0.0 30.0 19.3 0.0 0.0 0.0 0.0 0.0 0.0 36.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 17.0 0.0 0.0 0.0 0.0 81.3 5.8 0.0 0.0 0.0 MARCHF7 "AXOT, MARCH-VII, MARCH7, RNF177" ENSG00000136536 "Membrane associated ring-CH-type finger 7" Q9H992 2 159712457-159771027 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in some" "Adipocytes: 33.3;Cardiomyocytes: 88.4;Cytotrophoblasts: 36.2;dendritic cells: 28.2;Extravillous trophoblasts: 38.8;Hofbauer cells: 34.0;Syncytiotrophoblasts: 44.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA014275, HPA022152" Enhanced Supported "Plasma membrane,Cytosol" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 23: Testis - Cell cycle regulation" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 24: Non-specific - Transcription regulation" "Plasma membrane, Cytosol" "HPA014275: AB_10599820, HPA022152: AB_10601107" "unprognostic (2.42e-1)" "unprognostic (2.24e-1)" "unprognostic (1.02e-2)" "unprognostic (1.92e-2)" "unprognostic (1.62e-2)" "unprognostic (2.10e-1)" "prognostic unfavorable (2.41e-4)" "unprognostic (2.46e-2)" "unprognostic (6.42e-2)" "unprognostic (3.44e-1)" "unprognostic (3.17e-2)" "unprognostic (3.53e-2)" "prognostic unfavorable (1.84e-4)" "unprognostic (1.41e-3)" "unprognostic (1.38e-1)" "unprognostic (2.57e-1)" "unprognostic (1.61e-1)" 38.3 30.0 16.4 37.9 21.7 43.2 48.2 32.3 21.5 38.6 25.1 33.2 30.0 45.0 34.2 67.3 37.5 38.1 48.9 15.8 16.1 32.8 40.1 38.2 47.9 17.4 17.1 47.5 22.3 36.6 22.7 46.9 17.7 38.1 36.9 37.9 26.9 36.3 55.2 38.6 30.0 50.6 14.9 45.1 33.5 62.0 17.1 60.8 47.5 44.1 52.2 39.0 37.5 21.8 50.3 35.3 88.7 40.7 61.9 81.9 89.1 83.9 81.1 82.5 73.9 70.9 57.5 71.0 36.8 84.2 46.8 61.3 55.4 74.5 102.9 75.9 43.2 96.0 53.8 53.3 60.7 79.9 72.6 72.7 83.0 99.5 86.5 92.5 99.3 50.7 75.6 65.6 82.9 44.2 52.4 73.8 84.6 54.6 47.3 75.0 64.5 59.3 74.6 112.1 51.9 48.6 65.6 48.2 67.0 94.3 56.9 94.4 93.5 86.9 51.9 53.9 47.2 51.5 61.0 96.8 54.1 46.8 84.0 83.5 28.8 59.6 28.6 29.5 33.3 27.6 30.4 32.4 27.6 26.4 36.3 35.9 127.5 39.4 43.4 22.3 34.3 30.9 16.4 21.7 32.3 21.5 15.8 16.1 17.4 17.1 17.7 14.9 17.1 21.8 33.3 0.0 0.0 0.0 7.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 88.4 0.0 0.0 0.0 0.0 36.2 28.2 0.0 0.0 0.0 0.0 0.0 0.0 8.9 0.0 0.0 0.0 0.0 38.8 13.5 0.0 0.0 0.0 0.0 0.0 0.0 34.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.0 0.0 0.0 0.0 0.0 44.2 5.8 0.0 0.0 0.0 MARCHF8 "c-MIR, CMIR, MARCH-VIII, MARCH8, MIR, RNF178" ENSG00000165406 "Membrane associated ring-CH-type finger 8" Q5T0T0 10 45454585-45594906 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Adaptive immunity, Immunity, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in some" 4 "Cardiomyocytes: 26.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA014597 Approved NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 44: HDLM-2 - Immune response" "Cluster 24: Non-specific - Transcription regulation" "HPA014597: AB_1853580" "unprognostic (1.38e-1)" "unprognostic (3.69e-2)" "unprognostic (1.74e-1)" "unprognostic (1.68e-3)" "unprognostic (1.32e-1)" "unprognostic (2.01e-2)" "unprognostic (3.51e-1)" "unprognostic (2.58e-1)" "unprognostic (1.56e-2)" "unprognostic (2.04e-1)" "prognostic favorable (2.71e-4)" "unprognostic (1.28e-1)" "prognostic favorable (6.64e-4)" "unprognostic (1.01e-1)" "unprognostic (1.24e-1)" "unprognostic (1.85e-1)" "unprognostic (3.12e-2)" 14.3 19.2 11.8 12.4 18.5 49.1 16.8 19.3 13.1 13.8 11.7 21.3 14.2 14.4 10.4 10.6 15.3 13.4 20.5 11.1 13.1 15.5 16.9 15.0 16.9 18.8 14.2 19.5 26.5 19.8 16.0 12.2 17.3 11.5 18.3 18.2 14.8 15.2 14.7 10.5 22.4 13.8 14.7 18.7 14.4 57.1 16.1 17.8 16.3 15.4 20.3 11.4 9.0 26.7 16.6 16.4 13.7 12.4 19.4 24.2 10.1 7.5 35.0 13.6 14.8 4.2 16.8 23.8 12.6 21.9 12.3 3.0 15.2 12.4 12.6 36.3 16.7 9.2 7.4 10.0 13.6 11.3 39.1 19.8 16.3 6.8 17.9 13.4 22.5 22.4 26.5 23.2 10.5 5.8 11.5 7.1 4.5 2.4 5.3 12.7 13.7 7.0 10.2 9.5 12.2 17.0 14.7 3.5 14.0 13.3 21.2 5.2 15.1 10.6 13.6 15.6 12.0 39.8 34.2 10.5 21.0 15.5 2.9 13.9 1.1 10.8 3.0 1.9 4.5 3.5 3.4 3.3 1.6 5.4 2.5 3.2 14.1 8.5 0.9 1.6 3.6 2.5 11.8 18.5 19.3 13.1 11.1 13.1 18.8 14.2 17.3 14.7 16.1 26.7 6.1 0.0 0.0 0.0 4.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 26.6 0.0 0.0 0.0 0.0 2.0 6.3 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 1.7 2.8 0.0 0.0 0.0 0.0 0.0 0.0 6.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.2 0.0 0.0 0.0 0.0 1.6 1.3 0.0 0.0 0.0 MARCHF9 "FLJ36578, MARCH9, RNF179" ENSG00000139266 "Membrane associated ring-CH-type finger 9" Q86YJ5 12 57755103-57760411 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in some" 4 "Adipocytes: 6.0;B-cells: 6.6;Cardiomyocytes: 12.3;dendritic cells: 12.0;Hofbauer cells: 7.3;Plasma cells: 8.3;T-cells: 3.4" "Cancer enriched" "Detected in all" 4 "glioma: 39.3" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enriched" "Detected in many" 12 "RH-30: 515.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 77: Retina - Visual perception" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 24: Non-specific - Transcription regulation" "unprognostic (2.96e-2)" "unprognostic (6.78e-2)" "unprognostic (1.90e-3)" "prognostic favorable (3.07e-4)" "unprognostic (2.16e-1)" "unprognostic (6.85e-2)" "unprognostic (8.15e-3)" "prognostic favorable (1.54e-5)" "unprognostic (7.76e-2)" "prognostic favorable (1.59e-4)" "unprognostic (1.08e-2)" "unprognostic (1.06e-1)" "prognostic favorable (2.98e-5)" "unprognostic (2.44e-1)" "unprognostic (2.86e-1)" "unprognostic (2.45e-1)" "unprognostic (1.34e-1)" 8.8 17.6 15.3 7.8 16.0 5.1 10.0 17.7 16.9 11.3 14.5 13.5 7.6 9.0 8.4 12.6 8.4 6.4 17.3 15.6 16.1 28.0 8.6 19.0 13.9 14.8 15.2 8.9 17.4 17.9 34.9 7.7 14.2 16.5 6.5 40.6 14.3 8.5 13.0 17.9 20.0 4.7 14.6 29.0 14.8 5.2 15.5 19.4 25.4 9.0 13.8 9.8 10.0 14.3 15.3 7.5 11.6 12.7 1.2 0.4 15.0 2.3 16.0 8.8 8.5 9.7 12.0 37.3 12.1 0.4 15.2 13.6 19.1 16.3 5.7 22.4 21.1 4.8 5.9 5.0 10.7 4.6 7.5 1.8 16.8 2.5 8.9 26.0 3.8 36.9 6.9 37.1 2.3 14.5 24.3 5.8 7.6 10.8 16.1 19.9 515.3 40.6 17.5 13.4 26.1 17.1 1.1 1.2 10.4 5.6 26.4 9.1 0.3 11.4 9.1 6.5 7.5 41.8 20.4 22.6 12.5 1.1 11.7 2.0 0.4 0.1 3.2 0.6 5.0 4.6 5.1 4.4 1.4 5.8 5.0 3.7 0.2 2.6 0.2 9.8 3.3 1.1 15.3 16.0 17.7 16.9 15.6 16.1 14.8 15.2 14.2 14.6 15.5 14.3 6.0 0.0 0.0 0.0 6.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.3 0.0 0.0 0.0 0.0 1.9 12.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.8 1.6 0.0 0.0 0.0 0.0 0.0 0.0 7.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 1.1 3.4 0.0 0.0 0.0 MARK1 "MARK, PAR-1C" ENSG00000116141 "Microtubule affinity regulating kinase 1" Q9P0L2 1 220528136-220664461 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Autism, Autism spectrum disorder" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 73.8;Excitatory neurons: 171.3;Inhibitory neurons: 170.1;Oligodendrocyte precursor cells: 167.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HAP1: 11.3;RT4: 33.7;SuSa: 12.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007421, HPA008061" Uncertain NA NA "Cluster 77: Retina - Visual perception" "Cluster 15: RT4 - Unknown function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA007421: AB_1079311, HPA008061: AB_1079310" "unprognostic (1.51e-1)" "unprognostic (6.27e-2)" "unprognostic (6.72e-2)" "unprognostic (3.63e-2)" "unprognostic (2.23e-1)" "unprognostic (1.01e-1)" "unprognostic (1.54e-2)" "unprognostic (3.48e-1)" "prognostic unfavorable (2.63e-4)" "unprognostic (4.59e-2)" "prognostic favorable (2.23e-5)" "unprognostic (6.62e-2)" "unprognostic (4.27e-2)" "unprognostic (9.56e-3)" "unprognostic (3.35e-2)" "unprognostic (1.72e-1)" "unprognostic (3.74e-2)" 6.3 1.8 6.9 1.4 7.1 0.0 4.9 6.4 10.0 4.6 8.4 5.4 0.4 4.2 9.7 4.8 3.3 1.7 8.0 7.4 6.7 2.3 0.3 3.1 0.5 6.4 6.8 1.7 0.9 2.4 6.9 1.1 7.4 3.0 1.2 9.3 3.7 4.0 2.2 2.5 2.5 3.9 5.7 1.3 2.8 6.9 6.5 1.4 4.3 3.5 1.9 5.3 5.1 6.4 0.4 0.0 5.4 1.1 0.0 0.0 1.8 1.6 2.2 1.8 2.5 0.0 0.0 0.0 0.0 0.0 2.5 2.5 11.3 6.0 1.0 0.0 8.4 0.0 2.3 0.0 0.0 0.7 0.8 0.9 4.7 0.0 3.0 0.8 0.2 2.7 0.0 0.0 0.0 0.0 0.0 0.0 8.1 5.5 1.8 0.0 7.4 0.0 0.0 33.7 6.4 6.2 0.3 0.3 0.5 12.2 0.5 0.0 0.0 0.0 2.4 4.0 7.1 0.0 0.0 0.0 1.2 0.0 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.9 7.1 6.4 10.0 7.4 6.7 6.4 6.8 7.4 5.7 6.5 6.4 3.2 0.0 0.5 73.8 0.5 3.4 2.6 10.0 13.1 28.6 1.6 3.8 21.9 0.0 4.7 3.7 31.3 2.1 0.0 0.7 0.0 1.6 7.3 19.3 6.4 3.4 9.0 0.0 171.3 0.0 2.3 6.3 2.6 35.5 0.0 13.6 3.3 0.0 0.3 10.1 170.1 0.4 4.1 0.3 1.5 3.6 2.1 0.2 0.0 15.0 0.0 12.3 0.0 167.9 45.9 0.1 0.0 6.4 0.6 4.8 1.5 0.2 4.1 11.9 0.0 6.9 17.5 17.4 5.1 13.1 3.3 1.0 0.4 1.1 0.9 4.8 MARK2 "EMK1, PAR-1, PAR-1B, Par1b" ENSG00000072518 "Microtubule affinity regulating kinase 2" Q7KZI7 11 63838928-63911020 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Differentiation, Wnt signaling pathway" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038790, HPA074905" Approved Supported "Nucleoplasm,Plasma membrane" NA NA "Cluster 10: Basophils - Unknown function" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" "Plasma membrane" Nucleoplasm "HPA038790: AB_10674840, HPA074905: AB_2686722" "unprognostic (1.33e-2)" "unprognostic (2.45e-2)" "unprognostic (1.64e-1)" "prognostic unfavorable (3.21e-4)" "unprognostic (7.13e-2)" "unprognostic (3.82e-2)" "prognostic unfavorable (1.30e-4)" "unprognostic (2.73e-3)" "unprognostic (4.41e-1)" "unprognostic (5.79e-2)" "unprognostic (3.94e-3)" "unprognostic (3.77e-1)" "unprognostic (5.20e-3)" "unprognostic (5.15e-3)" "unprognostic (6.78e-2)" "unprognostic (1.03e-1)" "unprognostic (2.40e-1)" 11.3 13.8 12.6 21.1 16.1 24.0 16.8 8.1 16.3 18.5 10.8 25.9 26.1 14.6 7.7 51.8 16.6 14.1 20.9 14.9 9.3 13.9 13.1 17.0 21.5 11.8 9.3 12.0 22.4 19.4 19.8 14.9 11.5 20.5 22.4 8.8 27.0 13.1 20.8 40.9 25.1 16.3 7.3 24.1 20.9 10.6 9.5 23.2 19.5 13.7 24.0 19.3 25.0 17.9 52.0 34.1 26.6 28.6 14.6 18.6 35.2 20.8 20.0 29.5 22.3 34.1 49.5 37.8 35.6 20.8 32.0 57.5 26.9 28.7 24.6 26.7 20.9 40.7 23.9 20.3 17.0 45.9 51.4 10.9 36.8 27.0 21.4 13.5 24.7 33.6 35.7 36.5 19.5 64.4 49.3 29.9 31.7 36.0 24.2 39.9 20.4 39.7 19.1 39.8 37.9 25.4 34.7 90.2 24.3 28.9 65.1 26.4 22.7 30.3 19.1 39.6 23.4 24.5 28.8 36.7 20.1 23.2 25.3 1.4 0.7 2.1 1.3 0.7 2.1 0.9 1.0 1.3 1.0 1.6 0.8 0.9 3.6 1.6 1.1 0.9 0.6 0.7 12.6 16.1 8.1 16.3 14.9 9.3 11.8 9.3 11.5 7.3 9.5 17.9 17.3 6.4 6.8 29.7 18.5 25.2 21.1 9.1 19.4 26.8 30.0 18.2 12.8 27.1 11.9 20.2 8.4 26.0 33.4 90.3 1.9 20.2 0.6 29.5 15.8 14.7 29.9 14.7 43.6 21.4 20.6 11.7 27.0 41.0 17.2 21.1 13.6 13.0 17.9 20.2 30.3 39.9 10.2 26.7 18.5 0.9 12.8 25.0 3.6 29.0 17.0 18.8 36.0 31.7 51.8 27.3 39.4 10.9 15.6 30.4 33.4 8.1 14.5 18.1 19.7 19.6 13.1 9.1 18.4 39.9 34.4 65.0 23.6 16.0 33.6 44.3 MARK3 "CTAK1, KP78, PAR-1A" ENSG00000075413 "Microtubule affinity regulating kinase 3" P27448 14 103385377-103503831 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 32 "eosinophil: 101.5" "Lineage enriched" "Detected in all" 32 "granulocytes: 101.5" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA024652 Approved NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 59: Non-specific - Translation" "Cluster 30: Epithelial cell lines - Translation" "Cluster 52: Non-specific - Transcription" "HPA024652: AB_1853582" "unprognostic (6.86e-2)" "unprognostic (2.93e-1)" "unprognostic (7.70e-2)" "unprognostic (3.48e-2)" "unprognostic (8.41e-2)" "unprognostic (1.50e-1)" "unprognostic (2.31e-3)" "unprognostic (2.21e-1)" "prognostic unfavorable (1.14e-4)" "unprognostic (2.29e-3)" "unprognostic (3.66e-2)" "unprognostic (1.55e-2)" "unprognostic (1.13e-1)" "unprognostic (4.71e-2)" "unprognostic (1.34e-1)" "unprognostic (1.33e-2)" "unprognostic (1.60e-1)" 34.6 52.5 14.9 23.0 15.9 53.2 27.5 16.0 22.1 29.8 15.1 34.8 20.4 31.3 26.7 39.8 36.8 20.8 71.5 14.5 14.8 38.7 30.8 38.3 24.9 15.1 15.0 33.7 46.7 33.8 32.0 22.8 16.2 30.5 21.3 23.2 29.2 24.2 71.0 27.3 31.8 30.8 15.0 42.6 46.5 38.4 14.7 31.0 33.2 42.7 26.2 32.1 28.5 15.6 28.1 33.3 52.8 34.7 64.3 43.6 40.9 54.9 56.8 66.3 62.4 23.3 46.2 36.3 31.9 52.5 27.0 51.5 58.3 56.6 81.2 39.4 28.0 46.8 34.9 30.8 123.5 53.4 27.2 56.1 51.5 53.1 105.0 51.9 61.0 33.0 45.4 77.1 51.2 61.6 34.9 38.4 42.0 57.7 56.0 44.9 56.2 30.1 54.1 52.3 44.5 43.1 59.0 36.6 52.1 58.7 50.8 47.1 50.2 34.8 23.4 62.1 48.4 44.4 67.0 42.1 41.5 40.8 48.0 0.3 1.5 101.5 1.4 1.1 0.9 1.5 2.2 2.8 1.8 0.6 2.4 1.6 2.3 1.4 1.1 1.2 3.1 0.7 14.9 15.9 16.0 22.1 14.5 14.8 15.1 15.0 16.2 15.0 14.7 15.6 38.0 57.7 79.1 154.1 43.6 44.2 57.2 28.7 33.0 78.7 26.3 21.7 74.6 47.1 45.2 38.6 162.6 33.3 47.9 36.6 11.7 46.8 38.0 47.5 63.7 50.9 31.2 187.1 153.5 42.0 31.0 47.3 52.0 62.1 48.2 128.7 63.9 30.1 30.2 58.9 145.0 32.3 30.5 40.4 63.0 52.4 60.9 42.6 37.4 70.3 57.5 34.4 61.8 138.2 172.3 60.4 34.0 59.0 55.9 67.4 34.6 21.5 36.8 86.7 32.9 38.9 44.1 74.6 72.4 36.1 52.1 49.1 54.8 98.9 33.7 114.6 MARK4 "FLJ90097, KIAA1860, MARKL1, Nbla00650, PAR-1D" ENSG00000007047 "Microtubule affinity regulating kinase 4" Q96L34 19 45079288-45305284 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell cycle, Cell division, Cilium biogenesis/degradation, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Horizontal cells: 119.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039186 Approved Supported Cytosol NA NA "Cluster 10: Basophils - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 12: NES - Nervous system development" "Cluster 62: Horizontal cells - Visual perception" Cytosol "HPA039186: AB_10796223" "unprognostic (1.64e-1)" "unprognostic (1.95e-1)" "unprognostic (1.57e-3)" "prognostic unfavorable (8.31e-8)" "unprognostic (2.02e-1)" "prognostic unfavorable (3.05e-5)" "unprognostic (1.90e-1)" "unprognostic (2.16e-2)" "unprognostic (6.26e-2)" "unprognostic (5.64e-3)" "unprognostic (1.24e-3)" "unprognostic (7.50e-2)" "unprognostic (3.80e-2)" "unprognostic (6.89e-2)" "unprognostic (7.23e-2)" "unprognostic (4.65e-2)" "unprognostic (3.02e-2)" 13.1 13.5 27.5 7.2 31.4 8.5 13.0 16.1 37.7 17.1 11.3 16.5 5.0 15.5 16.6 16.4 14.8 10.6 17.3 31.6 19.6 13.5 21.8 13.9 8.3 24.0 25.2 21.7 14.0 20.5 16.6 11.6 22.6 16.2 5.8 26.0 12.7 13.0 38.7 26.9 9.1 14.6 14.1 11.4 14.3 40.4 29.9 13.1 12.7 12.0 9.6 19.0 16.7 26.1 20.3 7.7 36.6 23.8 25.3 36.8 8.8 15.3 25.1 21.8 20.8 4.0 10.8 8.5 12.0 28.9 20.6 13.5 26.4 22.5 14.2 15.7 16.0 20.7 8.5 17.0 47.6 4.4 15.1 48.1 31.9 18.7 22.8 43.3 29.5 22.1 22.6 21.8 24.9 14.4 16.7 14.5 12.3 18.6 4.7 61.5 11.4 6.3 23.4 16.0 58.8 27.1 20.5 17.5 12.5 35.9 9.0 29.3 21.6 16.7 12.9 12.2 9.0 22.7 21.8 10.8 17.9 8.4 12.7 1.1 1.0 0.2 1.0 0.7 0.2 0.2 0.3 1.3 0.3 0.2 0.6 0.7 0.9 0.7 0.7 0.9 0.8 0.4 27.5 31.4 16.1 37.7 31.6 19.6 24.0 25.2 22.6 14.1 29.9 26.1 8.7 12.8 3.1 30.7 6.0 25.0 11.3 7.2 15.4 20.9 10.2 7.0 9.1 11.5 4.4 9.2 25.0 4.3 8.1 3.7 11.7 8.4 2.3 6.6 9.5 12.2 6.1 6.1 31.1 6.1 1.5 8.4 10.2 10.5 2.5 18.9 18.5 10.7 7.0 119.5 36.5 4.7 4.1 9.5 11.0 6.3 16.1 8.2 3.6 16.9 5.9 19.6 12.3 23.1 16.4 9.5 3.5 13.9 7.7 13.0 4.7 6.5 2.5 15.6 0.0 7.6 8.4 1.2 8.3 12.5 24.2 11.5 10.3 26.1 3.2 15.5 MAST1 "KIAA0973, SAST" ENSG00000105613 "Microtubule associated serine/threonine kinase 1" Q9Y2H9 19 12833951-12874952 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "brain: 37.7;pituitary gland: 23.3;retina: 15.4" "Cell type enhanced" "Detected in many" "Bipolar cells: 24.7;Cone photoreceptor cells: 43.8;Excitatory neurons: 64.7;Inhibitory neurons: 70.3;Oligodendrocyte precursor cells: 22.1;Rod photoreceptor cells: 20.4" "Cancer enhanced" "Detected in many" "glioma: 3.5" "Region enhanced" "Detected in many" "cerebral cortex: 37.7" "Immune cell enhanced" "Detected in single" "MAIT T-cell: 1.0" "Lineage enriched" "Detected in single" 9 "T-cells: 1.0" "Cell line enhanced" "Detected in many" "AN3-CA: 23.3;SCLC-21H: 40.5;SH-SY5Y: 20.2;U-266/70: 16.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028181, HPA073106" Enhanced Supported Vesicles,Cytosol NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 58: Brain - Synaptic function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Vesicles Cytosol "HPA028181: AB_10603872, HPA073106: AB_2732218" "unprognostic (6.32e-2)" "unprognostic (3.66e-2)" "unprognostic (3.93e-2)" "unprognostic (2.83e-5)" "unprognostic (1.72e-1)" "unprognostic (4.19e-2)" "unprognostic (2.38e-1)" "unprognostic (8.72e-2)" "unprognostic (1.04e-1)" "unprognostic (3.64e-1)" "unprognostic (8.89e-3)" "unprognostic (3.43e-2)" "unprognostic (3.84e-3)" "unprognostic (1.19e-1)" "unprognostic (7.04e-2)" "unprognostic (2.49e-2)" "unprognostic (1.96e-1)" 0.0 2.2 6.5 0.3 12.1 0.3 0.1 7.3 37.7 0.2 0.0 1.2 0.3 0.0 0.0 0.2 0.1 0.2 0.2 8.3 2.4 0.1 0.6 0.1 0.1 11.2 1.1 0.3 0.6 0.5 23.3 0.0 9.5 0.2 0.1 15.4 0.2 0.0 0.0 3.7 0.4 0.0 0.0 0.1 0.6 5.0 1.2 0.8 0.1 0.0 0.0 0.2 0.3 3.0 3.6 1.6 1.5 23.3 0.0 0.0 1.9 0.2 0.1 0.3 0.9 0.8 1.5 5.8 2.6 0.0 3.9 0.1 6.8 0.1 0.1 4.1 4.5 0.5 5.8 2.6 0.0 1.3 1.2 0.5 0.1 0.8 0.7 1.3 0.0 15.2 5.2 3.0 0.0 0.8 2.4 0.6 6.9 0.6 7.2 15.9 4.6 8.3 0.3 0.2 40.5 20.2 0.8 1.4 4.3 1.2 3.8 2.1 0.0 2.8 4.2 3.1 0.8 16.7 14.5 3.7 5.1 3.1 0.1 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.6 0.0 6.5 12.1 7.3 37.7 8.3 2.4 11.2 1.1 9.5 0.0 1.2 3.0 0.5 0.0 2.4 7.8 0.2 0.9 1.6 0.6 0.6 24.7 0.8 2.5 1.0 0.0 0.3 0.0 43.8 0.6 0.4 0.6 0.0 0.4 14.0 0.2 0.2 1.3 0.0 0.0 64.7 0.5 0.6 1.3 0.0 0.3 1.3 0.5 1.1 0.5 0.2 15.2 70.3 0.1 0.0 1.0 1.2 8.2 0.6 0.7 5.4 6.5 0.1 3.7 0.0 22.1 3.0 0.3 2.5 1.2 0.0 1.0 0.9 0.2 1.0 20.4 0.0 2.0 0.5 8.0 5.2 0.7 1.4 0.3 1.0 0.4 0.7 1.2 MAST2 "KIAA0807, MAST205" ENSG00000086015 "Microtubule associated serine/threonine kinase 2" Q6P0Q8 1 45786987-46036122 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 170.6" "Cell type enhanced" "Detected in many" "Distal enterocytes: 66.9;Inhibitory neurons: 86.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "non-classical monocyte: 1.5" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039722, HPA040155" Approved Approved Cytosol NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "HPA039722: AB_10795294, HPA040155: AB_10793957" "unprognostic (7.80e-2)" "unprognostic (3.02e-2)" "unprognostic (5.77e-2)" "unprognostic (1.52e-1)" "unprognostic (3.82e-1)" "unprognostic (3.17e-2)" "prognostic unfavorable (4.31e-8)" "unprognostic (8.86e-2)" "unprognostic (2.34e-2)" "unprognostic (1.98e-1)" "unprognostic (1.60e-1)" "unprognostic (1.75e-1)" "prognostic unfavorable (6.85e-13)" "unprognostic (4.82e-3)" "unprognostic (2.43e-1)" "unprognostic (9.73e-2)" "unprognostic (4.90e-1)" 18.3 11.8 16.2 11.0 15.5 8.0 18.7 15.4 17.5 57.4 7.3 39.1 21.9 43.5 12.8 14.7 31.2 19.0 65.3 15.2 19.4 12.2 18.9 17.8 8.9 19.7 27.7 51.9 9.2 13.9 27.0 8.6 26.4 40.0 25.3 24.0 18.4 15.4 170.6 14.6 30.7 26.3 14.6 7.2 24.0 56.3 18.3 5.8 13.2 73.1 11.1 46.9 28.8 15.7 31.7 25.1 24.7 19.2 30.7 41.4 27.6 32.2 22.8 29.4 32.6 29.4 10.1 48.8 15.2 38.6 59.9 15.7 30.1 18.8 30.4 23.7 16.4 22.2 29.2 27.4 28.4 12.0 27.3 34.1 23.7 49.8 37.0 35.2 27.5 12.5 17.3 14.6 34.2 21.9 17.7 12.5 20.4 21.2 28.2 25.6 40.7 9.4 16.1 16.8 34.0 20.6 38.0 50.4 16.3 26.9 22.8 11.9 27.9 55.7 36.8 30.1 33.0 19.5 18.9 17.5 38.0 16.0 24.2 0.0 0.3 0.4 0.3 0.2 0.4 0.0 0.2 0.4 0.6 0.1 0.1 0.2 0.0 0.5 1.5 0.0 0.0 0.2 16.2 15.5 15.4 17.5 15.2 19.4 19.7 27.7 26.4 14.6 18.3 15.7 5.5 0.0 2.0 32.0 2.3 4.2 4.1 3.0 8.0 15.8 8.2 6.7 46.5 4.3 5.5 3.7 54.2 6.1 2.4 66.9 1.9 4.6 38.0 4.4 17.0 7.3 12.1 6.5 45.4 6.3 4.8 12.0 12.8 7.8 0.0 13.0 3.6 6.6 6.2 5.0 86.6 24.6 0.0 2.8 7.8 57.7 9.0 5.3 7.2 30.9 2.5 3.7 7.2 52.3 52.5 8.3 33.9 10.1 5.5 10.7 50.2 5.7 3.1 12.8 6.6 11.7 9.0 28.0 13.2 6.3 2.7 5.5 3.5 12.4 22.4 7.4 MAST3 KIAA0561 ENSG00000099308 "Microtubule associated serine/threonine kinase 3" O60307 19 18097793-18151692 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 62.1" "Cell type enhanced" "Detected in many" "Excitatory neurons: 62.6;Oligodendrocytes: 63.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035061, HPA035062" Uncertain Approved "Nuclear speckles" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 10: Brain - Neuronal signaling" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nuclear speckles" "HPA035061: AB_10670585, HPA035062: AB_10671508" "unprognostic (5.94e-3)" "unprognostic (4.75e-2)" "unprognostic (1.70e-1)" "unprognostic (1.02e-1)" "unprognostic (3.38e-1)" "prognostic favorable (2.97e-4)" "unprognostic (1.93e-1)" "unprognostic (4.63e-2)" "unprognostic (1.43e-1)" "unprognostic (3.21e-1)" "prognostic favorable (7.01e-4)" "unprognostic (2.58e-1)" "unprognostic (1.64e-3)" "unprognostic (1.02e-2)" "unprognostic (3.61e-1)" "unprognostic (1.58e-3)" "unprognostic (1.26e-3)" 4.9 4.8 49.9 9.2 53.4 14.4 3.7 0.0 62.1 9.4 0.0 7.3 9.6 5.3 4.7 3.3 7.1 3.1 3.7 61.6 0.0 7.6 14.5 9.1 11.2 5.3 1.9 7.1 20.2 5.0 15.5 2.6 4.3 5.6 4.3 1.0 4.8 3.9 3.0 7.3 12.4 3.0 0.0 19.2 4.5 3.6 13.7 4.2 4.5 1.6 10.1 3.7 4.9 47.4 3.5 5.1 2.3 10.2 6.7 5.4 5.5 3.5 2.2 2.4 3.4 5.2 4.7 9.0 5.1 3.5 2.6 1.9 3.4 2.0 1.7 7.7 4.2 4.1 5.7 8.3 5.6 2.2 13.2 6.2 5.7 3.6 1.4 3.2 1.1 6.1 4.3 5.8 2.8 6.3 4.7 7.3 2.4 7.7 6.2 12.6 2.0 6.6 1.9 1.5 3.8 6.2 4.9 2.8 2.1 1.6 3.2 5.1 4.0 3.0 3.2 13.1 1.5 6.2 9.0 8.0 6.7 11.6 2.9 0.3 6.2 14.8 11.7 8.0 8.4 5.9 6.3 4.7 3.2 5.9 4.9 8.4 32.9 8.1 14.7 15.4 7.6 6.1 49.9 53.4 0.0 62.1 61.6 0.0 5.3 1.9 4.3 0.0 13.7 47.4 2.6 6.4 9.4 5.5 13.5 0.5 0.8 2.8 2.8 3.0 2.6 2.8 1.5 7.2 3.6 9.2 2.1 0.5 19.0 30.0 3.9 2.9 9.3 2.8 5.4 3.8 2.4 1.3 62.6 10.5 1.5 3.4 7.7 1.5 2.5 3.0 4.6 16.3 7.7 0.0 6.1 8.5 0.0 21.7 6.3 30.8 4.1 13.3 5.4 19.7 19.6 0.9 32.0 8.0 63.7 7.1 7.9 6.8 5.1 1.2 16.7 8.8 4.2 0.7 0.0 2.1 3.0 0.6 3.9 2.3 2.3 0.4 11.0 5.3 13.0 0.6 MAST4 KIAA0303 ENSG00000069020 "Microtubule associated serine/threonine kinase family member 4" O15021 5 66596361-67169595 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "Astrocytes: 519.7;Basal prostatic cells: 507.3;Excitatory neurons: 636.6;Inhibitory neurons: 489.6;Suprabasal keratinocytes: 399.2;Urothelial cells: 676.4" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "cerebral cortex: 27.7" "Immune cell enhanced" "Detected in many" "basophil: 15.2" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HBEC3-KT: 33.2;HDLM-2: 43.2;HEL: 35.5;RT4: 42.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000544 Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 38: Basophils - Unknown function" "Cluster 46: Fibroblasts - ECM organization" "Cluster 36: HEL - Hemostasis" "Cluster 22: Epithelial cell types - Mixed function" "Nucleoplasm, Cytosol" "HPA000544: AB_1079315" "unprognostic (1.77e-2)" "unprognostic (6.24e-2)" "unprognostic (1.80e-1)" "unprognostic (4.99e-3)" "unprognostic (2.83e-2)" "prognostic favorable (5.18e-5)" "unprognostic (9.01e-2)" "unprognostic (1.00e-1)" "unprognostic (2.79e-2)" "unprognostic (9.47e-2)" "unprognostic (5.03e-2)" "unprognostic (3.01e-2)" "unprognostic (1.01e-2)" "unprognostic (1.37e-2)" "unprognostic (2.63e-1)" "unprognostic (2.63e-1)" "unprognostic (3.08e-2)" 14.9 11.0 4.6 4.5 5.2 1.9 11.1 0.9 27.7 12.1 0.0 6.0 5.1 10.0 5.0 27.0 9.4 8.0 29.5 4.2 5.4 12.0 8.4 11.0 4.4 5.0 5.5 16.4 4.6 15.3 4.6 8.8 1.2 7.6 4.1 4.7 11.5 6.6 11.2 14.8 4.5 9.3 1.1 5.0 7.0 10.0 3.3 16.8 6.5 7.2 10.1 16.0 21.2 11.4 14.6 7.8 3.8 0.2 12.4 10.9 9.0 3.2 4.9 1.1 1.0 7.3 3.9 1.0 6.5 2.7 2.9 12.8 11.8 33.2 1.3 43.2 3.8 35.5 4.7 3.1 0.9 0.1 11.9 18.4 17.8 7.1 14.2 13.3 26.2 3.2 3.5 3.9 8.9 12.6 5.1 0.2 2.5 1.2 6.3 1.1 3.3 0.7 3.1 42.9 5.5 4.4 4.3 1.7 0.2 2.7 2.8 0.2 25.2 3.0 4.1 4.6 5.4 9.9 4.8 0.2 7.7 0.1 2.4 15.2 0.3 0.8 0.9 0.4 2.5 2.9 4.0 1.0 0.4 2.5 4.2 1.8 3.5 2.3 0.9 1.0 6.9 1.3 4.6 5.2 0.9 27.7 4.2 5.4 5.0 5.5 1.2 1.1 3.3 11.4 130.2 32.1 53.3 519.7 11.4 368.6 507.3 127.9 114.9 15.9 79.3 38.1 139.1 27.1 78.7 18.4 2.1 40.7 4.9 24.4 37.2 59.0 129.2 35.8 5.3 111.8 32.2 5.5 636.6 115.8 50.0 33.2 28.5 55.3 93.8 19.4 70.6 42.2 5.1 8.4 489.6 18.1 40.7 6.9 33.7 127.4 41.3 9.8 48.0 78.7 2.1 55.2 4.1 165.9 108.4 70.8 27.2 32.7 13.5 355.5 14.8 93.9 57.2 4.5 39.5 15.9 31.1 14.8 9.2 211.7 399.2 137.2 21.0 14.7 16.1 676.4 MASTL "FLJ14813, Gwl, THC2" ENSG00000120539 "Microtubule associated serine/threonine kinase like" Q96GX5 10 27154824-27187953 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 24.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Not detected" "Not detected" "Not detected" "Not detected" "HPA027175, HPA054273" Approved Enhanced Nucleoplasm NA Yes "Cluster 8: Neutrophils - Inflammatory response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "HPA027175: AB_1853591, HPA054273: AB_2682433" "unprognostic (4.10e-2)" "unprognostic (6.89e-2)" "unprognostic (1.22e-2)" "unprognostic (3.14e-3)" "unprognostic (3.67e-1)" "unprognostic (1.97e-2)" "prognostic unfavorable (2.52e-6)" "unprognostic (2.19e-2)" "unprognostic (4.00e-2)" "unprognostic (4.05e-2)" "prognostic unfavorable (4.81e-5)" "unprognostic (3.78e-2)" "prognostic unfavorable (1.71e-6)" "unprognostic (1.55e-3)" "unprognostic (2.27e-1)" "unprognostic (2.66e-1)" "unprognostic (1.79e-1)" 5.0 3.9 1.7 6.2 1.9 18.7 5.3 2.3 2.3 3.8 2.1 4.1 4.4 3.9 4.5 5.9 3.0 3.9 2.5 1.9 2.0 3.9 4.9 4.0 8.9 2.0 2.0 3.4 3.3 6.0 3.1 6.5 2.1 3.1 5.2 2.7 4.1 3.0 2.3 6.0 4.3 4.5 1.6 4.6 4.7 6.5 2.0 10.4 4.7 2.2 7.1 4.5 4.3 2.3 29.4 22.0 43.8 15.5 6.2 9.1 25.4 43.3 18.0 68.4 83.8 26.7 27.2 22.4 16.1 18.4 33.5 26.8 27.9 16.0 48.2 20.2 26.5 26.9 14.5 15.5 3.8 10.4 19.8 5.6 7.5 41.6 7.9 9.0 14.7 18.2 21.1 49.9 41.5 17.9 34.8 11.2 32.0 15.9 8.9 22.2 71.9 18.9 17.4 10.6 19.2 26.8 26.0 17.6 19.1 28.1 17.2 21.4 12.6 17.0 36.3 44.0 37.4 5.9 10.3 34.7 18.3 31.1 14.8 0.2 1.8 1.7 0.7 1.7 1.1 1.1 0.9 0.7 1.0 1.6 0.9 0.8 2.3 1.0 1.8 1.1 1.6 0.8 1.7 1.9 2.3 2.3 1.9 2.0 2.0 2.0 2.1 1.6 2.0 2.3 4.3 6.4 7.8 2.6 7.4 11.0 4.9 4.4 4.0 1.7 4.2 4.8 3.0 2.8 7.0 1.8 0.0 8.6 10.1 7.0 0.0 4.0 3.0 9.7 5.3 4.6 4.2 7.8 4.3 2.5 24.9 7.3 6.1 17.9 12.7 6.9 2.5 2.5 5.8 3.3 4.3 3.7 4.1 7.8 19.3 1.7 3.1 11.3 0.0 3.7 5.1 1.8 3.1 3.5 4.9 4.4 2.9 2.6 7.1 5.0 2.8 1.9 4.0 1.0 0.0 3.8 5.3 14.9 14.1 10.9 9.9 6.2 11.6 5.4 4.5 6.6 MAT1A "MAT, MATA1, SAMS, SAMS1" ENSG00000151224 "Methionine adenosyltransferase 1A" Q00266 10 80271820-80289658 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "One-carbon metabolism" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 23 "liver: 1346.5" "Cell type enriched" "Detected in some" 55 "Hepatocytes: 5534.4" "Cancer enriched" "Detected in many" 54 "liver cancer: 209.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 14 "Hep G2: 94.9" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA048627 Supported NA NA 1900000 "Cluster 62: Liver - Hemostasis" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 2: Hepatocytes - Metabolism" "HPA048627: AB_2680465" "unprognostic (6.92e-2)" "unprognostic (2.63e-1)" "unprognostic (2.88e-2)" "unprognostic (9.43e-2)" "unprognostic (3.79e-2)" "unprognostic (2.49e-2)" "unprognostic (2.03e-3)" "unprognostic (1.46e-1)" "unprognostic (1.09e-1)" "unprognostic (2.58e-2)" "unprognostic (1.76e-1)" "unprognostic (8.66e-2)" "unprognostic (1.11e-16)" "unprognostic (8.59e-3)" "unprognostic (9.90e-2)" "unprognostic (3.58e-1)" "unprognostic (5.98e-2)" 0.5 0.5 0.4 0.1 0.8 0.0 0.4 0.1 0.5 0.2 0.9 0.2 0.2 0.1 57.5 0.1 1.2 0.0 0.2 0.2 0.2 0.9 1346.5 0.4 0.1 0.6 0.8 6.3 43.8 0.1 0.8 0.1 0.4 0.0 0.0 0.0 0.3 1.9 0.0 4.2 0.0 0.2 0.8 0.5 0.2 3.7 0.2 0.4 0.4 0.0 0.0 0.5 0.1 0.2 6.5 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.5 0.0 0.2 0.3 0.0 3.2 0.1 0.0 0.0 0.0 0.3 0.5 1.6 0.0 94.9 0.0 0.5 0.0 0.0 0.1 0.0 0.0 0.2 0.0 2.1 0.2 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.3 1.0 0.2 0.0 0.5 0.0 0.0 0.2 0.0 1.2 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.1 0.2 0.0 0.3 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.8 0.1 0.5 0.2 0.2 0.6 0.8 0.4 0.8 0.2 0.2 0.0 0.0 0.5 0.0 8.8 2.0 0.1 0.4 0.0 0.0 0.2 0.6 0.7 67.2 0.9 1.8 0.0 0.0 0.0 0.0 1.9 0.1 23.9 3.0 0.0 5.3 0.0 69.5 0.1 4.6 0.0 0.0 0.0 0.2 0.0 7.6 76.8 5534.4 0.1 0.0 0.0 0.0 0.0 100.4 0.6 5.3 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.4 0.0 0.1 0.0 0.6 10.2 0.0 0.0 0.0 0.2 2.7 0.3 0.0 2.7 0.0 6.0 1.0 0.0 0.0 MAT2A "MATA2, MATII, SAMS2" ENSG00000168906 "Methionine adenosyltransferase 2A" P31153 2 85539168-85545281 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "One-carbon metabolism" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "pancreas: 874.7" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009968, HPA043028" Approved Approved Nucleoplasm,Cytosol NA NA 1800000 "Cluster 39: Non-specific - mRNA processing" "Cluster 22: Non-specific - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 41: Macrophages - Immune response" Nucleoplasm Cytosol "CAB009968: AB_675710, HPA043028: AB_10960707" "unprognostic (1.38e-3)" "unprognostic (2.58e-2)" "unprognostic (3.96e-2)" "prognostic unfavorable (5.29e-5)" "unprognostic (9.89e-3)" "unprognostic (5.90e-3)" "prognostic unfavorable (4.87e-4)" "prognostic favorable (8.94e-4)" "prognostic unfavorable (5.94e-5)" "unprognostic (4.07e-2)" "unprognostic (2.02e-1)" "unprognostic (2.59e-2)" "unprognostic (9.63e-3)" "unprognostic (1.04e-1)" "unprognostic (2.02e-1)" "unprognostic (4.39e-2)" "unprognostic (1.77e-2)" 270.4 277.5 184.1 153.2 226.7 98.3 136.1 199.3 235.9 173.0 152.6 193.2 141.4 165.5 236.0 166.2 200.1 209.5 189.6 191.5 207.3 203.6 115.7 168.5 121.8 226.8 219.3 211.0 874.7 165.8 284.1 122.3 208.0 196.2 146.5 248.7 137.7 120.0 278.9 141.1 155.6 127.2 194.4 116.7 225.5 132.3 219.2 102.1 388.8 112.0 127.7 262.9 168.2 289.7 175.3 253.0 290.4 181.6 195.3 236.7 171.1 213.5 195.6 219.3 232.4 208.4 569.9 404.5 137.0 261.0 178.9 264.3 369.6 318.6 279.8 207.0 271.0 242.5 408.7 181.9 355.6 364.3 259.7 215.9 315.8 237.4 164.1 278.1 211.5 230.7 277.9 309.0 505.1 149.5 334.4 398.2 193.5 148.7 320.8 350.3 275.0 264.2 328.9 271.2 227.9 209.6 193.2 183.4 354.6 145.9 156.0 192.3 207.7 267.4 160.9 149.3 260.5 189.0 161.4 290.6 175.0 447.3 143.8 9.1 24.7 8.2 22.3 26.9 32.7 19.8 25.2 23.7 23.6 18.9 23.1 20.5 2.5 27.3 22.3 16.6 24.2 24.9 184.1 226.7 199.3 235.9 191.5 207.3 226.8 219.3 208.0 194.4 219.2 289.7 150.5 48.1 83.6 122.4 104.2 143.5 217.1 47.1 206.1 73.5 116.3 134.6 6.5 82.9 57.6 71.7 68.8 36.2 126.3 60.6 19.6 59.2 75.2 28.8 49.2 83.6 83.3 87.1 56.1 58.5 40.6 121.9 106.0 47.4 84.4 83.3 45.0 44.6 67.4 26.9 60.4 65.1 26.4 118.8 141.9 25.8 72.1 165.7 67.6 26.2 64.6 58.8 27.8 28.6 95.5 53.6 48.0 83.8 78.4 66.7 73.8 138.7 35.2 89.0 111.7 298.5 231.0 54.1 56.2 168.2 118.3 38.2 102.0 51.1 70.6 88.4 MATK "CHK, CTK, DKFZp434N1212, HHYLTK, HYL, HYLTK, Lsk, MGC1708, MGC2101" ENSG00000007264 "Megakaryocyte-associated tyrosine kinase" P42679 19 3777970-3802129 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 20.5;brain: 41.9" "Cell type enhanced" "Detected in many" "dendritic cells: 177.0;Hofbauer cells: 57.4;NK-cells: 422.2;T-cells: 99.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "NK-cell: 76.8" "Group enriched" "Detected in many" 57 "NK-cells: 76.8;T-cells: 46.2" "Cell line enhanced" "Detected in some" "HL-60: 108.3;HMC-1: 30.9;K-562: 48.9;MCF7: 34.4;NB-4: 74.8;SCLC-21H: 30.9;THP-1: 27.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004847, HPA066547" Approved Approved "Microtubules,Cytokinetic bridge,Mitotic spindle,Centriolar satellite,Cytosol" Yes NA "Cluster 48: NK-cells - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 1: K-562 - Erythropoiesis" "Cluster 63: NK-cells & T-cells - Immune response" Microtubules "Cytokinetic bridge, Mitotic spindle, Centriolar satellite, Cytosol" "HPA004847: AB_1079316, HPA066547: " "prognostic favorable (5.27e-4)" "unprognostic (1.28e-2)" "unprognostic (1.84e-1)" "unprognostic (3.54e-2)" "unprognostic (3.36e-1)" "unprognostic (3.39e-2)" "unprognostic (9.50e-2)" "unprognostic (1.23e-1)" "unprognostic (7.91e-2)" "unprognostic (3.19e-3)" "unprognostic (2.07e-2)" "unprognostic (4.51e-2)" "unprognostic (1.16e-2)" "unprognostic (7.59e-2)" "unprognostic (1.66e-1)" "unprognostic (2.26e-1)" "unprognostic (2.33e-2)" 4.7 1.3 18.3 6.6 21.3 20.5 2.5 2.9 41.9 1.1 1.6 2.1 6.6 0.9 0.1 2.1 4.0 4.4 1.4 25.9 8.7 2.4 3.2 9.9 9.4 10.4 11.0 0.7 1.2 0.7 2.7 1.0 8.8 1.3 1.1 2.2 3.2 0.7 0.8 1.9 6.2 0.8 4.7 16.5 4.0 3.1 14.1 3.8 1.6 0.2 4.0 1.6 1.1 23.6 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.5 0.0 0.2 1.7 0.0 1.0 10.6 13.8 0.4 0.0 0.0 18.1 12.0 1.5 2.9 0.0 108.3 30.9 0.1 0.0 0.2 0.1 0.0 0.0 1.2 48.9 0.1 0.0 34.4 0.3 74.8 8.4 9.0 0.3 0.0 0.1 0.0 0.0 0.0 30.9 0.1 0.1 0.1 0.1 0.9 0.0 27.4 3.3 0.0 0.6 1.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 46.2 0.0 31.3 0.0 5.7 29.3 0.8 0.9 2.7 16.4 1.0 76.8 0.2 0.3 0.4 7.6 18.3 21.3 2.9 41.9 25.9 8.7 10.4 11.0 8.8 4.7 14.1 23.6 1.4 0.0 1.1 0.3 11.1 0.4 0.1 0.0 0.0 1.4 4.9 7.2 1.3 0.0 0.0 0.0 12.5 0.3 177.0 0.3 0.0 0.0 2.0 0.2 0.5 1.9 7.1 28.6 17.7 0.0 0.5 0.8 11.7 0.5 44.5 0.1 8.6 1.1 57.4 0.0 8.3 0.3 0.0 6.0 14.6 5.1 0.0 11.5 1.8 4.7 3.0 1.3 422.2 2.0 1.6 0.0 1.1 0.0 17.1 0.1 0.3 0.2 0.7 2.0 0.0 0.5 1.2 0.4 4.5 1.3 1.1 0.3 99.7 0.0 1.1 0.0 MBOAT1 "dJ434O11.1, LPEAT1, MGC44669, OACT1" ENSG00000172197 "Membrane bound O-acyltransferase domain containing 1" Q6ZNC8 6 20099684-20212469 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Gastric mucus-secreting cells: 18.8;Langerhans cells: 25.2;Oligodendrocytes: 41.5;Respiratory ciliated cells: 19.1;Suprabasal keratinocytes: 15.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HaCaT: 42.2;HEL: 40.6;T-47d: 31.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 48: Smooth muscle cells - ECM organization" "unprognostic (1.26e-2)" "unprognostic (4.18e-2)" "unprognostic (2.06e-2)" "unprognostic (5.85e-3)" "unprognostic (3.88e-2)" "unprognostic (5.31e-2)" "unprognostic (2.55e-2)" "unprognostic (6.57e-3)" "unprognostic (1.87e-1)" "unprognostic (1.62e-3)" "prognostic unfavorable (9.15e-4)" "unprognostic (2.90e-2)" "unprognostic (5.59e-2)" "unprognostic (5.17e-2)" "unprognostic (2.56e-1)" "unprognostic (1.70e-1)" "unprognostic (4.24e-2)" 7.3 3.3 1.4 6.0 3.6 11.1 12.5 4.6 2.4 13.3 1.9 19.2 13.8 14.2 5.8 10.5 21.7 8.4 5.9 1.1 2.1 6.1 4.5 7.4 5.4 7.4 3.8 12.5 5.8 5.7 2.4 4.0 6.3 9.3 18.9 1.2 8.1 5.3 1.9 6.8 16.4 8.4 4.6 7.3 15.2 1.4 4.1 2.7 7.6 2.2 5.2 8.6 10.9 9.4 4.5 4.7 8.3 6.6 0.9 2.7 0.6 7.1 2.0 4.4 5.1 2.3 19.0 0.0 14.5 6.8 3.9 42.2 7.6 3.6 6.3 11.3 4.5 40.6 7.9 0.1 5.5 10.6 11.9 1.2 3.6 1.9 8.1 2.3 2.4 7.1 5.4 7.2 1.0 4.7 6.3 10.1 2.1 4.4 2.3 2.0 9.1 25.0 5.9 8.7 0.4 5.3 1.4 8.6 9.0 15.9 31.2 5.3 2.0 6.0 4.2 3.6 3.4 9.7 20.9 0.1 0.6 7.9 7.9 39.9 27.6 66.8 3.9 33.3 20.2 2.6 9.1 7.2 15.1 1.6 2.6 2.6 34.4 4.4 41.1 18.5 13.5 7.9 1.4 3.6 4.6 2.4 1.1 2.1 7.4 3.8 6.3 4.6 4.1 9.4 1.3 3.2 0.5 0.3 1.7 11.0 0.9 3.5 4.6 0.0 2.4 1.3 0.4 0.0 6.6 0.0 0.0 0.1 3.7 3.5 1.9 2.7 0.0 4.7 3.1 2.5 0.0 8.4 1.1 1.2 0.1 6.4 18.8 7.5 0.0 1.9 1.1 0.0 1.5 0.0 0.5 2.0 2.0 1.0 25.2 0.0 0.3 4.4 8.8 6.5 4.5 1.3 0.0 0.0 41.5 1.5 7.7 0.0 1.5 0.8 5.5 0.0 19.1 0.1 0.0 1.0 3.6 0.0 0.1 5.4 15.5 0.3 6.4 10.4 3.0 1.8 MBOAT2 "FLJ14415, FLJ90298, OACT2" ENSG00000143797 "Membrane bound O-acyltransferase domain containing 2" Q6ZWT7 2 8852690-9003709 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 171.1;Erythroid cells: 162.6;Excitatory neurons: 134.6;Horizontal cells: 141.3;Oligodendrocyte precursor cells: 177.4;Oligodendrocytes: 230.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 7 "basophil: 4.7;eosinophil: 1.7;neutrophil: 4.0" "Lineage enriched" "Detected in single" 10 "granulocytes: 4.7" "Cell line enhanced" "Detected in many" "SK-BR-3: 41.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA014836 Uncertain Approved Vesicles NA NA "Cluster 38: Basophils - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Vesicles "HPA014836: AB_1854745" "unprognostic (2.49e-1)" "unprognostic (2.17e-2)" "unprognostic (2.61e-1)" "prognostic unfavorable (2.13e-9)" "unprognostic (1.30e-1)" "unprognostic (2.32e-2)" "unprognostic (2.38e-1)" "unprognostic (3.97e-3)" "unprognostic (3.09e-1)" "unprognostic (3.00e-1)" "unprognostic (1.03e-3)" "unprognostic (1.70e-1)" "unprognostic (5.90e-2)" "unprognostic (2.23e-1)" "unprognostic (3.04e-2)" "unprognostic (6.66e-2)" "prognostic unfavorable (5.32e-4)" 2.2 2.1 16.4 2.4 23.6 26.9 9.0 20.5 18.4 7.7 26.2 7.6 2.4 4.6 2.7 15.8 2.9 3.6 4.6 18.9 21.9 7.0 0.8 6.7 1.9 21.8 22.2 5.8 1.4 29.3 5.4 3.2 22.4 14.4 8.5 15.6 5.7 2.3 1.1 11.6 3.7 3.9 20.6 2.4 6.1 2.1 21.9 2.4 4.5 1.1 4.8 3.8 8.4 29.3 14.0 4.2 12.7 5.4 5.6 12.5 7.3 6.5 2.4 8.5 5.6 1.1 21.9 3.9 7.5 15.9 6.8 10.5 11.4 13.5 12.6 12.3 19.0 16.7 5.9 0.0 6.9 0.0 5.0 9.1 7.8 8.1 5.6 18.5 4.5 5.5 14.4 3.0 7.5 3.6 4.9 0.3 5.0 6.4 15.8 7.4 20.0 0.1 12.6 2.0 7.6 23.0 6.9 41.1 6.6 6.2 7.7 4.8 2.5 14.7 7.7 11.6 19.0 1.1 0.4 4.3 23.3 2.4 5.1 4.7 0.4 1.7 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 4.0 0.0 0.1 0.1 0.0 0.2 16.4 23.6 20.5 18.4 18.9 21.9 21.8 22.2 22.4 20.6 21.9 29.3 7.7 19.2 12.7 171.1 1.7 3.3 4.6 33.1 0.6 20.6 18.1 12.1 12.2 7.2 54.7 40.5 8.4 3.9 1.1 28.2 5.9 5.6 9.7 3.2 19.4 13.4 37.6 162.6 134.6 1.5 1.4 12.7 21.4 2.9 8.2 14.7 4.6 0.2 1.8 141.3 107.8 59.3 32.6 1.9 17.7 12.7 5.3 5.0 14.2 33.7 29.0 98.7 0.0 177.4 230.5 88.1 42.9 7.5 0.3 19.5 1.6 10.4 45.7 8.8 6.6 10.5 15.2 12.1 24.8 24.4 5.1 1.9 2.0 1.9 12.7 66.4 MCAT "fabD, FASN2C, MCT, MCT1, MT, NET62" ENSG00000100294 "Malonyl-CoA-acyl carrier protein transacylase" Q8IVS2 22 43132209-43143398 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Proximal tubular cells: 94.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003122, HPA035471" Approved Supported Mitochondria NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 18: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Mitochondria "HPA003122: AB_2666795, HPA035471: AB_10670590" "unprognostic (1.05e-1)" "unprognostic (1.57e-2)" "unprognostic (1.39e-2)" "prognostic favorable (5.53e-4)" "unprognostic (3.52e-1)" "unprognostic (1.34e-1)" "unprognostic (1.36e-3)" "unprognostic (4.71e-2)" "unprognostic (5.13e-2)" "unprognostic (2.94e-1)" "unprognostic (1.32e-1)" "unprognostic (9.86e-2)" "prognostic favorable (2.18e-4)" "prognostic favorable (3.89e-4)" "unprognostic (3.67e-2)" "unprognostic (1.76e-1)" "unprognostic (3.08e-1)" 10.2 21.6 11.8 5.7 12.5 9.0 11.7 11.1 14.4 9.2 17.1 12.5 6.7 11.5 9.9 15.5 14.3 6.6 18.2 13.6 12.5 25.1 22.7 8.7 5.1 11.9 11.6 11.3 15.0 17.6 16.6 4.6 12.2 13.5 7.1 7.2 13.3 6.6 21.9 14.9 8.6 5.8 10.6 8.1 14.8 17.1 12.0 7.8 13.1 10.1 6.1 10.8 10.3 11.0 14.1 18.2 12.6 22.3 10.4 11.0 12.9 15.4 13.6 20.3 18.8 18.3 14.1 23.6 15.5 11.5 11.5 23.3 24.1 20.4 15.1 8.2 71.3 8.8 21.6 20.6 16.6 42.3 10.3 8.3 19.5 19.9 15.7 11.8 14.7 14.1 21.1 9.4 10.1 26.0 19.9 46.0 12.3 19.8 31.8 26.0 12.4 37.7 25.7 12.1 16.6 8.8 16.6 32.0 24.3 5.7 16.5 27.1 8.9 8.8 17.4 19.2 22.0 16.6 18.4 17.1 19.0 16.0 10.8 0.0 11.4 0.8 8.8 11.1 11.5 9.4 9.7 11.4 16.4 12.4 10.9 7.9 2.9 14.5 6.9 16.2 7.0 7.3 11.8 12.5 11.1 14.4 13.6 12.5 11.9 11.6 12.2 10.6 12.0 11.0 8.0 6.4 6.8 3.9 6.9 17.8 12.3 19.6 5.7 11.2 13.6 11.4 9.5 31.5 10.6 20.2 0.0 18.7 5.7 12.3 50.9 32.0 23.4 28.5 8.3 9.4 14.5 17.9 3.6 21.8 11.9 8.8 12.2 9.2 3.8 10.8 17.5 22.3 15.5 6.7 3.7 14.7 14.2 6.3 4.3 11.8 7.5 6.1 7.2 0.0 8.2 12.5 4.1 1.5 2.1 23.7 15.2 16.6 5.6 17.3 12.5 94.3 27.7 9.6 19.7 11.2 10.0 30.0 11.7 9.0 21.0 9.2 4.8 30.5 22.4 11.5 MCM3AP "GANP, KIAA0572, Map80, SAC3" ENSG00000160294 "Minichromosome maintenance complex component 3 associated protein" O60318 21 46235133-46286297 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters" "Immunity, mRNA transport, Protein transport, Translocation, Transport" "Acyltransferase, Transferase" "Mental retardation, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021527, HPA032103" Approved Supported "Nucleoplasm,Nuclear membrane,Cytosol" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 1: K-562 - Erythropoiesis" "Cluster 59: Non-specific - Transcription" "Nuclear membrane, Cytosol" Nucleoplasm "HPA021527: AB_1853626, HPA032103: AB_2674152" "unprognostic (1.75e-1)" "unprognostic (1.31e-1)" "unprognostic (2.31e-1)" "unprognostic (2.20e-1)" "unprognostic (1.72e-1)" "unprognostic (6.31e-3)" "unprognostic (1.48e-2)" "unprognostic (2.06e-1)" "unprognostic (4.17e-2)" "unprognostic (4.76e-3)" "prognostic favorable (2.05e-4)" "unprognostic (1.96e-1)" "unprognostic (2.81e-3)" "unprognostic (1.04e-1)" "unprognostic (1.05e-1)" "unprognostic (3.85e-3)" "unprognostic (2.28e-1)" 16.8 12.0 10.0 20.3 11.5 19.7 13.6 8.9 10.7 14.7 17.0 15.1 14.0 16.5 8.3 14.3 15.2 14.2 15.1 8.5 7.8 13.0 9.7 16.0 21.0 10.8 10.4 17.6 15.4 16.9 9.2 16.3 9.5 14.2 15.0 12.8 13.7 13.4 41.3 13.8 16.1 17.1 9.4 19.6 15.4 14.1 11.0 21.7 16.0 28.7 21.5 13.6 11.2 14.6 38.0 36.3 41.8 45.5 33.1 41.4 38.0 40.8 48.1 37.1 30.2 33.1 21.9 53.6 32.9 43.2 40.3 21.9 55.9 34.0 32.7 55.7 50.8 87.9 35.0 25.9 29.6 40.6 47.7 31.7 28.7 51.2 35.2 25.4 40.7 31.7 107.3 39.6 43.3 21.1 43.5 26.8 72.3 40.0 30.2 56.3 26.6 48.9 17.8 34.1 35.2 37.6 52.4 33.7 39.0 31.5 46.0 41.2 51.6 39.1 29.7 33.1 31.0 71.8 86.2 33.0 35.3 38.0 51.8 0.6 2.0 1.6 2.3 1.9 2.4 1.1 1.3 2.6 1.9 1.6 1.2 1.3 1.2 1.1 1.1 1.6 1.8 2.1 10.0 11.5 8.9 10.7 8.5 7.8 10.8 10.4 9.5 9.4 11.0 14.6 17.3 9.6 18.9 28.1 21.3 7.0 7.1 9.0 22.2 21.8 13.8 13.0 4.7 14.3 12.7 11.0 20.9 11.4 20.6 17.5 1.9 11.3 3.5 16.8 23.7 14.8 12.0 18.5 28.0 14.2 11.7 12.8 27.0 17.7 8.8 20.1 11.7 18.6 15.4 16.8 34.2 19.2 10.2 19.7 8.4 4.3 18.3 18.6 10.6 34.7 24.3 9.3 16.5 37.2 35.3 15.9 8.6 14.3 21.6 14.0 13.8 6.6 15.5 21.7 19.7 17.9 12.9 19.7 15.0 21.2 10.4 9.3 19.1 16.0 17.9 7.9 MDM2 "HDM2, MGC5370" ENSG00000135679 "MDM2 proto-oncogene" Q00987 12 68808177-68850686 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Host-virus interaction, Ubl conjugation pathway" Transferase "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Endometrial ciliated cells: 257.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HBEC3-KT: 504.6;U-698: 517.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000086, CAB016303, CAB079977" Supported Supported "Nucleoplasm,Golgi apparatus,Cytosol" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 49: Ciliated cells - Cilium organization" "Nucleoplasm, Cytosol" "Golgi apparatus" "CAB000086: AB_563872, CAB016303: AB_627920, CAB079977: " "unprognostic (1.16e-1)" "prognostic favorable (3.23e-4)" "unprognostic (6.16e-2)" "prognostic favorable (4.51e-7)" "unprognostic (7.25e-2)" "unprognostic (6.91e-2)" "unprognostic (3.77e-2)" "unprognostic (1.72e-1)" "unprognostic (2.45e-2)" "unprognostic (3.23e-1)" "unprognostic (1.80e-3)" "unprognostic (2.36e-1)" "unprognostic (4.22e-2)" "unprognostic (4.59e-2)" "unprognostic (1.81e-1)" "unprognostic (2.68e-1)" "unprognostic (8.95e-2)" 14.0 11.6 5.4 10.4 10.0 28.6 11.9 7.4 7.6 13.9 28.0 20.7 6.4 9.5 7.1 13.0 14.1 12.0 6.8 3.8 7.4 9.5 26.9 14.3 13.8 9.9 8.5 10.8 14.3 10.9 5.0 16.4 9.2 11.3 21.9 14.2 9.6 11.5 18.6 10.9 7.5 12.4 6.0 11.4 10.0 6.6 9.2 15.6 15.4 12.9 17.0 15.1 10.8 12.8 18.7 42.1 43.5 22.6 55.9 51.5 223.4 49.7 50.3 26.2 41.5 26.8 8.4 188.6 13.5 34.7 7.3 11.0 31.4 504.6 42.1 51.0 22.0 35.3 36.0 115.0 55.7 32.6 31.0 77.8 46.5 101.5 69.4 26.9 73.7 32.1 37.1 45.4 50.8 28.0 43.1 10.7 36.9 10.1 8.2 149.4 31.7 16.2 16.0 146.0 34.3 20.2 32.0 25.0 11.3 88.8 58.3 21.4 82.3 20.2 38.0 16.8 18.5 68.2 47.7 517.6 31.3 12.8 81.2 6.1 5.4 5.2 4.1 4.1 3.7 4.7 3.5 4.1 3.0 5.4 3.6 3.5 19.2 3.7 7.2 3.9 4.1 3.6 5.4 10.0 7.4 7.6 3.8 7.4 9.9 8.5 9.2 6.0 9.2 12.8 23.1 32.1 56.3 26.1 36.4 15.6 30.5 42.6 22.8 26.8 21.4 17.1 20.9 24.3 75.8 25.8 33.3 47.5 32.1 19.3 13.7 19.5 2.5 257.4 34.5 22.0 25.1 29.9 28.8 24.2 28.0 31.9 28.5 74.8 32.9 33.2 15.7 45.0 18.3 30.3 32.9 23.4 32.6 49.0 25.0 2.9 19.3 44.9 12.4 37.5 35.4 27.8 10.3 25.6 71.8 22.4 20.1 15.1 117.7 39.8 15.8 21.3 141.7 35.3 19.7 30.0 32.4 17.3 20.0 59.5 22.0 94.3 31.8 49.4 20.9 82.0 MECOM "EVI1, KMT8E, MDS1, MDS1-EVI1, PRDM3" ENSG00000085276 "MDS1 and EVI1 complex locus" Q03112 3 169083499-169663775 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Apoptosis, Differentiation, Transcription, Transcription regulation" "Developmental protein, DNA-binding, Methyltransferase, Transferase" "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "stomach 1: 73.3" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 184.8;Collecting duct cells: 125.0;Gastric mucus-secreting cells: 111.1;Glandular and luminal cells: 107.7;Microglial cells: 346.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "plasmacytoid DC: 1.6" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "HUVEC TERT2: 55.5;RPTEC TERT1: 71.2;RT4: 119.6;TIME: 53.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA046537 Supported Supported "Nuclear speckles" NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 46: Fibroblasts - ECM organization" "Cluster 15: RT4 - Unknown function" "Cluster 44: Endometrium - Transcription" "Nuclear speckles" "HPA046537: AB_2679689" "unprognostic (4.09e-2)" "unprognostic (1.96e-1)" "unprognostic (3.24e-3)" "unprognostic (7.29e-2)" "unprognostic (2.87e-2)" "unprognostic (2.53e-1)" "unprognostic (1.83e-2)" "unprognostic (4.77e-3)" "unprognostic (1.53e-2)" "unprognostic (3.27e-3)" "prognostic unfavorable (2.59e-4)" "unprognostic (1.87e-1)" "unprognostic (2.60e-3)" "unprognostic (6.54e-2)" "unprognostic (1.03e-1)" "unprognostic (2.81e-2)" "unprognostic (3.37e-3)" 16.0 0.9 7.3 7.3 7.2 1.4 12.3 8.5 7.3 21.3 2.4 24.9 19.8 17.3 4.4 13.5 23.4 8.3 13.0 4.9 6.3 41.3 1.4 25.5 1.5 9.1 7.2 2.3 23.3 1.7 4.2 17.4 8.9 6.9 30.0 1.8 8.8 8.0 4.3 2.6 10.2 8.0 4.1 6.2 73.3 3.0 8.1 2.0 5.7 12.0 5.3 30.4 7.5 6.3 25.8 0.7 0.9 0.2 3.7 2.7 1.1 3.7 4.2 1.1 2.2 10.7 26.1 0.9 39.1 0.6 5.5 13.4 10.2 15.7 3.1 1.4 16.6 16.7 7.6 1.1 0.4 0.3 5.1 5.7 2.2 1.0 12.1 12.0 55.5 1.4 13.0 1.8 10.3 9.8 0.9 0.4 1.7 13.5 6.6 9.8 13.1 0.3 71.2 119.6 1.0 3.1 1.3 6.7 0.3 1.5 7.1 1.1 53.4 9.7 6.6 2.5 16.9 1.4 0.7 0.9 4.8 1.0 1.6 0.9 0.4 0.1 0.0 0.1 0.1 0.1 0.0 0.0 0.5 0.2 0.0 0.0 0.3 0.4 0.5 1.6 0.1 0.0 7.3 7.2 8.5 7.3 4.9 6.3 9.1 7.2 8.9 4.1 8.1 6.3 80.2 60.9 184.8 16.0 0.6 2.2 33.3 29.4 10.2 0.0 1.2 0.9 11.4 2.8 69.6 125.0 0.0 1.1 0.1 25.5 52.8 1.6 10.4 71.9 5.8 70.5 19.9 7.4 10.3 75.4 0.2 4.8 111.1 107.7 9.5 0.8 69.3 0.2 0.0 0.0 9.1 29.0 20.3 0.6 1.9 3.2 0.3 2.6 1.8 346.6 1.0 0.0 0.0 6.0 13.8 49.8 19.3 0.0 0.3 13.9 6.2 0.7 53.2 0.1 0.0 1.4 5.7 3.0 1.2 39.4 1.4 0.4 1.3 0.5 53.9 45.4 MELK KIAA0175 ENSG00000165304 "Maternal embryonic leucine zipper kinase" Q14680 9 36572862-36677683 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 10.0;lymphoid tissue: 21.0" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 16.1;Erythroid cells: 15.2;Extravillous trophoblasts: 44.1;Spermatocytes: 23.2;Spermatogonia: 21.3" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Immune cell enriched" "Detected in single" 4 "T-reg: 1.7" "Lineage enriched" "Detected in single" 4 "T-cells: 1.7" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in some" "Low region specificity" "Detected in many" HPA017214 Uncertain NA Yes "Cluster 4: T-regs - Cell cycle regulation" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 12: Non-specific - Cell cycle regulation" "HPA017214: AB_1853798" "unprognostic (5.03e-2)" "unprognostic (9.57e-2)" "unprognostic (2.27e-2)" "unprognostic (3.42e-3)" "unprognostic (2.16e-1)" "unprognostic (1.23e-1)" "prognostic unfavorable (2.91e-7)" "prognostic unfavorable (3.99e-4)" "unprognostic (1.26e-2)" "unprognostic (1.60e-2)" "prognostic unfavorable (4.58e-4)" "unprognostic (4.69e-2)" "prognostic unfavorable (0.00e+0)" "unprognostic (8.86e-3)" "unprognostic (1.37e-1)" "unprognostic (2.40e-1)" "unprognostic (1.35e-1)" 0.9 0.5 0.0 5.7 0.0 10.0 1.4 0.0 0.1 1.3 0.0 6.8 5.2 1.0 0.0 7.9 0.3 0.6 0.2 0.0 0.0 0.3 0.7 0.9 10.0 0.0 0.1 0.2 0.3 0.1 0.0 5.3 0.1 0.3 8.5 0.0 1.2 0.1 0.0 3.4 4.4 2.4 0.0 2.0 3.2 9.2 0.3 21.0 0.3 0.1 11.7 1.7 2.3 0.0 123.4 62.1 81.6 48.5 11.1 18.8 47.1 88.8 62.2 121.5 148.2 47.8 47.3 40.9 27.8 43.8 106.5 41.0 71.7 55.5 133.1 112.3 28.6 32.0 69.1 48.1 4.3 50.2 39.0 6.9 9.8 93.9 53.0 15.6 62.2 61.9 41.7 63.2 100.9 40.9 63.1 23.4 65.1 55.1 47.9 57.4 54.9 25.8 37.7 40.7 55.1 40.8 47.4 45.3 28.6 45.2 38.0 23.7 30.8 65.4 81.8 56.1 82.3 12.3 47.9 60.7 41.2 36.8 91.3 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.2 1.7 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.7 1.9 4.6 0.9 3.5 0.0 0.0 0.9 0.8 0.4 0.0 2.0 0.0 0.0 16.1 0.7 4.5 0.0 1.1 2.8 2.9 1.4 1.3 0.0 15.2 0.8 1.1 44.1 3.3 4.6 2.1 0.0 7.8 1.4 0.7 10.1 0.0 0.7 4.7 4.1 1.6 3.0 2.7 1.2 1.9 0.0 0.0 3.1 0.0 2.1 1.0 0.4 1.7 2.7 0.0 10.2 0.5 0.6 0.1 2.0 0.0 0.0 0.0 3.7 23.2 21.3 9.3 1.7 8.9 2.7 0.7 8.9 2.3 MERTK "c-Eyk, mer, RP38, Tyro12" ENSG00000153208 "MER proto-oncogene, tyrosine kinase" Q12866 2 111898607-112029561 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Disease variant, Proto-oncogene, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 162.6;Kupffer cells: 119.8;Macrophages: 46.5;Microglial cells: 124.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 12 "intermediate monocyte: 8.6;non-classical monocyte: 5.5" "Lineage enriched" "Detected in single" 50 "monocytes: 8.6" "Cell line enhanced" "Detected in many" "CACO-2: 35.1;Hep G2: 39.9;HUVEC TERT2: 38.4;RT4: 23.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036196, HPA075622" Enhanced Approved "Endoplasmic reticulum,Plasma membrane,Midbody,Cytosol" Yes NA 65000000 "Cluster 7: Monocytes - Unknown function" "Cluster 26: Pituitary gland - Hormone signaling" "Cluster 39: CACO-2 - Unknown function" "Cluster 4: Macrophages - Innate immune response" "Plasma membrane" "Endoplasmic reticulum, Midbody, Cytosol" "HPA036196: AB_10670676, HPA075622: AB_2686759" "unprognostic (2.17e-2)" "unprognostic (8.10e-2)" "unprognostic (4.85e-2)" "unprognostic (2.68e-1)" "unprognostic (2.44e-1)" "unprognostic (1.77e-1)" "unprognostic (1.07e-1)" "prognostic favorable (4.74e-4)" "unprognostic (6.84e-2)" "unprognostic (1.25e-1)" "unprognostic (6.22e-2)" "unprognostic (3.72e-1)" "prognostic favorable (4.43e-5)" "unprognostic (5.13e-2)" "unprognostic (2.11e-1)" "unprognostic (5.86e-2)" "unprognostic (2.05e-2)" 20.1 59.8 22.8 13.5 28.0 1.5 15.3 18.0 29.3 12.6 44.7 10.9 12.3 11.5 26.3 8.4 15.5 12.0 7.0 22.0 22.5 11.4 21.0 13.6 13.1 23.5 22.3 12.6 9.9 21.2 15.5 20.1 22.4 14.1 7.9 16.6 6.4 16.3 3.2 6.4 14.3 14.4 18.4 30.6 13.9 17.2 30.1 6.8 10.1 4.6 8.9 13.6 9.4 22.0 1.0 1.7 7.6 17.3 0.4 0.2 12.3 0.0 0.2 1.0 1.7 35.1 2.2 0.1 8.1 0.1 7.9 0.2 10.2 0.0 1.4 1.5 5.5 7.0 0.0 39.9 0.3 0.2 1.5 0.5 0.0 8.9 0.6 4.0 38.4 1.5 2.2 3.5 2.9 1.8 0.0 9.1 4.8 1.1 6.0 2.9 2.1 3.0 19.4 23.4 0.3 7.2 0.2 0.5 3.2 2.7 0.0 0.4 5.8 1.0 3.4 0.1 0.0 3.1 4.8 0.1 0.0 1.4 0.0 0.0 0.6 0.0 0.0 8.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 5.5 0.1 0.0 0.2 22.8 28.0 18.0 29.3 22.0 22.5 23.5 22.3 22.4 18.4 30.1 22.0 8.8 3.2 27.7 162.6 1.7 1.7 2.9 0.3 1.8 0.6 2.1 4.3 2.7 2.8 6.4 0.0 2.1 3.3 0.4 1.2 1.9 1.1 2.3 8.0 4.7 10.2 0.0 0.4 5.0 1.0 1.1 3.2 0.5 12.1 0.0 3.8 28.5 9.2 25.5 0.0 7.0 2.0 0.0 119.8 1.8 2.7 5.0 46.5 0.0 124.6 1.5 7.7 0.0 10.6 0.6 1.2 1.9 6.8 10.8 2.9 4.4 1.9 1.5 11.3 6.6 1.5 9.2 0.6 1.5 0.6 1.3 18.9 1.3 3.5 1.9 1.6 MET "DFNB97, HGFR, RCCP2" ENSG00000105976 "MET proto-oncogene, receptor tyrosine kinase" P08581 7 116672196-116798377 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Deafness, Disease variant, FDA approved drug targets, Non-syndromic deafness, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 42.9" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 103.6;Club cells: 99.8;Glandular and luminal cells: 161.4;Pancreatic endocrine cells: 93.9;Prostatic glandular cells: 149.3;Urothelial cells: 128.6" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in many" 5 "cerebral cortex: 7.5;hippocampal formation: 6.6;midbrain: 2.5;pons: 4.9;white matter: 7.8" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A-431: 203.8;CAPAN-2: 219.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB005282, CAB018577, HPA055607" Approved Approved "Plasma membrane,Cytosol" "Secreted to blood" NA NA 179000000 100000000 "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 44: Endometrium - Transcription" "Plasma membrane, Cytosol" "CAB005282: AB_631940, CAB018577: AB_649068, HPA055607: AB_2682860" "unprognostic (1.60e-2)" "unprognostic (7.71e-2)" "unprognostic (2.53e-2)" "unprognostic (1.58e-1)" "unprognostic (3.57e-3)" "prognostic unfavorable (6.75e-4)" "unprognostic (1.68e-1)" "unprognostic (3.22e-2)" "unprognostic (3.81e-2)" "unprognostic (2.52e-2)" "prognostic unfavorable (1.21e-7)" "unprognostic (1.86e-1)" "unprognostic (1.25e-1)" "unprognostic (5.53e-2)" "unprognostic (8.88e-2)" "unprognostic (2.01e-2)" "unprognostic (2.20e-1)" 10.3 0.8 0.1 3.4 0.6 7.4 8.9 0.1 7.5 13.1 9.6 9.7 6.5 6.4 2.5 6.1 4.7 11.9 6.2 6.6 0.8 20.1 42.9 20.3 2.3 1.1 2.5 0.8 6.6 0.8 3.8 26.4 4.9 6.7 9.3 3.9 8.7 11.2 14.3 7.7 8.2 5.7 0.3 6.0 15.4 0.5 0.5 3.7 17.6 11.0 3.2 18.4 4.4 7.8 203.8 115.3 0.1 0.6 8.6 8.7 7.9 113.7 48.2 60.3 51.1 25.0 219.0 8.4 179.0 72.1 163.3 51.8 19.7 110.0 123.7 0.3 23.4 0.1 112.5 21.4 1.5 0.3 0.2 11.4 42.4 40.6 129.1 109.4 42.4 0.2 4.5 0.8 114.1 5.0 0.1 0.1 17.3 32.9 113.0 0.2 95.3 0.2 105.8 24.0 16.5 0.0 45.4 15.4 44.9 19.8 0.4 0.9 72.3 89.7 30.6 46.7 88.9 2.5 19.1 1.5 99.3 0.3 12.9 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.6 0.1 7.5 6.6 0.8 1.1 2.5 4.9 0.3 0.5 7.8 32.6 28.9 103.6 0.3 1.0 39.0 70.5 58.1 38.1 6.7 6.5 6.9 12.3 11.5 99.8 31.3 0.0 76.0 0.4 20.5 0.0 38.5 0.0 52.5 11.6 20.1 7.2 0.0 2.6 46.9 7.5 7.4 32.6 161.4 0.0 0.0 3.9 30.5 7.0 0.0 1.0 20.5 18.3 1.3 2.2 0.1 0.6 4.4 3.6 1.9 1.0 7.6 0.0 0.5 7.7 93.9 5.5 0.0 0.4 149.3 11.2 15.6 34.5 0.3 0.0 37.8 5.2 0.0 0.6 7.9 17.8 21.8 1.2 0.0 16.4 128.6 METTL1 "C12orf1, TRM8, TRMT8" ENSG00000037897 "Methyltransferase like 1" Q9UBP6 12 57768471-57772119 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "tRNA processing" "Methyltransferase, RNA-binding, Transferase, tRNA-binding" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Proximal tubular cells: 60.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in all" 6 "RH-30: 293.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020914, HPA050450" Uncertain Supported Nucleoplasm NA NA "Cluster 29: Plasmacytoid DCs - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm "HPA020914: AB_1853830, HPA050450: AB_2681130" "unprognostic (5.24e-2)" "unprognostic (2.60e-1)" "unprognostic (9.43e-2)" "unprognostic (3.46e-1)" "unprognostic (9.01e-2)" "unprognostic (1.41e-2)" "prognostic unfavorable (4.25e-6)" "unprognostic (5.67e-2)" "unprognostic (6.19e-2)" "unprognostic (1.14e-3)" "unprognostic (1.78e-1)" "unprognostic (2.32e-1)" "prognostic unfavorable (3.55e-6)" "unprognostic (7.75e-2)" "unprognostic (1.96e-1)" "unprognostic (5.01e-2)" "unprognostic (2.22e-1)" 13.6 23.2 8.9 9.8 9.2 11.0 12.8 8.7 11.9 9.8 9.9 8.4 4.0 10.8 20.8 13.1 10.2 5.5 10.3 9.2 9.4 22.0 17.5 9.3 8.1 9.2 9.3 11.3 28.0 9.1 12.7 8.7 9.0 13.4 10.8 3.7 10.6 7.1 15.5 11.7 6.9 12.3 8.9 9.0 9.8 9.9 9.6 4.8 14.3 6.9 9.3 16.5 9.4 9.0 24.7 44.1 17.7 14.9 22.6 15.7 23.4 24.8 23.1 41.9 24.7 32.0 32.6 28.8 45.7 33.0 23.1 27.9 27.4 39.8 38.0 17.2 32.6 34.9 17.4 35.0 17.9 39.0 17.4 14.7 32.7 47.8 33.5 18.9 22.2 17.8 34.1 28.2 23.1 47.0 26.1 39.6 40.6 29.1 41.5 23.0 293.1 43.1 33.6 29.8 18.7 16.2 26.9 29.6 22.9 16.0 38.5 32.0 17.1 17.4 18.0 29.6 34.0 13.2 9.3 32.6 24.4 25.3 34.5 0.0 7.1 0.0 8.0 10.8 27.4 6.9 10.0 9.6 16.3 10.5 13.4 13.2 1.1 12.9 1.8 19.3 5.1 7.5 8.9 9.2 8.7 11.9 9.2 9.4 9.2 9.3 9.0 8.9 9.6 9.0 6.3 9.6 3.3 0.7 8.3 10.5 17.1 14.8 13.6 3.7 12.2 12.4 4.3 10.0 14.1 5.5 0.0 18.7 3.1 6.3 25.4 16.8 12.1 5.3 13.2 8.2 6.6 6.3 0.8 24.1 25.3 11.3 10.2 8.9 12.7 8.7 3.3 7.9 22.7 3.3 0.6 8.4 12.2 2.2 9.8 10.9 11.1 6.4 7.2 0.0 16.7 2.6 3.1 3.5 1.1 12.3 2.3 4.9 14.9 15.4 1.1 60.4 2.6 5.4 0.0 9.7 13.0 8.0 17.7 12.1 10.4 9.7 4.1 14.0 10.7 11.3 METTL11B "C1orf184, HOMT1B" ENSG00000203740 "Methyltransferase like 11B" Q5VVY1 1 170145959-170168866 "Enzymes, Predicted intracellular proteins" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "heart muscle: 1.7;skeletal muscle: 1.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 4 "NTERA-2: 1.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA028049 Uncertain NA NA "Cluster 38: Heart - Muscle contraction" "Cluster 5: NTERA-2 - Transcription" "HPA028049: AB_10610139" "unprognostic (1.12e-1)" "unprognostic (2.57e-1)" "unprognostic (5.62e-2)" "unprognostic (7.59e-2)" "unprognostic (7.25e-2)" "unprognostic (1.19e-1)" "unprognostic (8.68e-2)" "unprognostic (5.24e-2)" "unprognostic (2.76e-3)" "unprognostic (5.43e-2)" "unprognostic (4.56e-1)" "unprognostic (5.79e-4)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 METTL16 "METT10D, MGC3329" ENSG00000127804 "Methyltransferase like 16" Q86W50 17 2405562-2511891 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Methyltransferase, RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020352, HPA059798" Uncertain Supported Nucleoplasm,Cytosol NA NA "Cluster 32: T-cells - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 52: Non-specific - Transcription" Nucleoplasm Cytosol "HPA020352: AB_1853828, HPA059798: AB_2684128" "unprognostic (4.94e-3)" "unprognostic (2.86e-2)" "unprognostic (2.29e-2)" "unprognostic (5.66e-3)" "unprognostic (1.50e-1)" "unprognostic (5.47e-2)" "unprognostic (3.35e-2)" "unprognostic (1.88e-1)" "unprognostic (1.25e-1)" "unprognostic (3.46e-1)" "prognostic favorable (3.06e-4)" "unprognostic (5.35e-2)" "unprognostic (4.85e-3)" "unprognostic (2.91e-2)" "unprognostic (2.32e-1)" "unprognostic (1.61e-1)" "unprognostic (2.68e-2)" 6.8 6.2 4.4 6.6 6.2 8.8 7.8 5.1 5.2 7.2 4.3 6.0 5.3 9.5 5.7 5.9 9.1 4.9 7.2 4.0 4.4 6.3 3.8 7.0 8.3 4.7 5.2 12.3 7.5 10.1 4.5 4.2 4.9 7.4 5.8 7.7 6.6 7.0 6.6 6.4 5.2 8.5 5.0 6.9 4.7 5.4 4.8 10.4 9.3 7.4 8.3 6.4 5.3 7.9 9.0 25.3 12.7 12.9 9.7 12.1 12.3 11.8 9.6 12.4 10.3 34.5 6.1 28.1 11.9 10.1 13.3 12.5 30.2 15.3 16.8 11.0 20.7 14.2 21.2 16.0 10.8 13.3 11.0 10.2 14.0 17.3 24.9 8.5 13.0 16.1 19.1 14.8 8.4 11.0 19.1 7.8 14.9 10.9 10.1 31.8 13.8 12.7 9.2 8.3 6.8 11.4 16.7 9.3 9.0 13.5 11.9 8.6 10.2 11.6 7.3 16.3 16.3 8.3 11.3 19.4 15.5 11.1 15.8 1.6 2.1 0.8 3.5 1.4 4.4 3.5 3.3 3.4 1.5 2.9 4.9 3.7 0.0 1.3 1.0 2.0 2.3 1.4 4.4 6.2 5.1 5.2 4.0 4.4 4.7 5.2 4.9 5.0 4.8 7.9 17.5 12.8 33.5 19.2 25.7 11.5 21.4 12.6 9.6 28.7 14.9 14.1 15.8 15.7 25.8 7.3 45.9 8.9 19.3 11.8 13.7 9.9 20.8 18.8 21.7 13.9 20.4 6.3 20.9 10.8 9.1 18.9 15.3 15.0 24.7 25.5 17.5 9.2 10.4 26.9 21.6 13.7 10.2 10.0 5.9 7.6 14.9 11.6 8.8 17.8 13.7 20.2 30.9 23.6 42.2 9.7 6.3 12.8 14.5 20.1 23.2 9.0 26.3 37.4 6.6 28.0 21.3 11.8 16.7 14.7 12.8 6.0 25.5 28.7 16.8 17.0 METTL3 "M6A, MT-A70, Spo8" ENSG00000165819 "Methyltransferase like 3" Q86U44 14 21498133-21511342 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Biological rhythms, Differentiation, DNA damage, Immunity, Innate immunity, Oogenesis, Spermatogenesis" "Methyltransferase, RNA-binding, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in all" 4 "Early spermatids: 188.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 23: Testis - Cell cycle regulation" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 23: Spermatids - Flagellum & Golgi organization" "unprognostic (1.62e-1)" "unprognostic (1.65e-1)" "unprognostic (5.75e-2)" "unprognostic (1.70e-1)" "unprognostic (1.22e-1)" "unprognostic (1.01e-1)" "prognostic unfavorable (2.19e-5)" "unprognostic (1.02e-3)" "unprognostic (1.85e-1)" "prognostic favorable (2.78e-4)" "prognostic favorable (2.72e-4)" "unprognostic (4.52e-2)" "unprognostic (4.64e-3)" "unprognostic (2.98e-2)" "unprognostic (7.14e-2)" "unprognostic (5.36e-2)" "unprognostic (1.22e-1)" 12.1 18.5 12.1 11.3 13.0 5.8 16.0 12.6 13.1 12.9 12.5 11.9 7.6 13.2 18.1 11.7 18.8 9.8 16.7 12.5 12.9 14.1 11.7 12.9 19.0 14.1 13.1 15.0 11.5 19.0 13.0 15.2 13.7 17.3 12.9 8.6 14.2 16.7 16.8 16.5 10.6 16.3 13.1 13.9 11.2 19.8 13.4 17.8 16.8 18.6 21.2 14.4 12.4 13.7 39.6 57.7 55.0 22.2 40.5 33.4 27.5 35.9 26.0 41.7 48.5 22.0 46.4 40.8 22.6 22.3 54.2 41.6 66.4 35.2 65.7 39.1 39.8 25.9 31.9 88.1 16.6 34.8 28.2 25.0 30.3 26.0 30.2 18.6 54.8 20.8 32.0 23.5 55.9 29.1 31.0 28.6 46.4 66.1 70.7 30.7 42.6 36.5 38.8 26.6 33.4 36.6 38.7 50.6 37.5 42.7 39.8 22.8 36.6 15.0 24.8 27.6 24.9 24.9 32.5 29.0 18.2 27.7 32.0 6.5 8.9 8.9 8.0 11.5 12.4 14.3 10.0 9.4 10.9 10.8 10.3 9.3 0.9 15.7 9.6 13.0 15.5 8.4 12.1 13.0 12.6 13.1 12.5 12.9 14.1 13.1 13.7 13.1 13.4 13.7 12.5 12.8 20.1 15.7 16.2 14.9 23.3 21.2 21.1 23.4 15.1 16.5 30.6 12.8 13.6 12.9 14.6 31.1 16.2 5.4 3.9 14.5 188.2 11.7 11.4 14.7 10.8 20.4 15.0 10.0 15.7 15.3 7.1 10.0 8.8 20.4 9.7 9.5 16.6 21.9 13.7 8.7 14.2 10.0 9.9 24.3 17.1 10.8 16.0 10.3 17.9 14.9 15.5 19.1 21.7 10.8 6.5 19.9 14.9 18.8 5.5 9.1 15.3 21.0 32.9 16.4 17.5 42.4 20.3 12.4 12.4 25.3 13.2 13.2 13.4 19.0 METTL4 "FLJ23017, HsT661" ENSG00000101574 "Methyltransferase like 4" Q8N3J2 18 2537525-2571509 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Chromatin regulator, Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040061, HPA046734" Approved Approved Mitochondria NA Yes "Cluster 41: Basophils - Cellular respiration" "Cluster 16: Immune cells - Immune response" "Cluster 16: U-266 - Nucleosome" "Cluster 59: Non-specific - Transcription" Mitochondria "HPA040061: AB_10697713, HPA046734: AB_2732532" "unprognostic (1.85e-2)" "unprognostic (1.27e-1)" "unprognostic (7.31e-2)" "unprognostic (1.07e-1)" "unprognostic (1.11e-1)" "unprognostic (5.06e-3)" "unprognostic (1.12e-5)" "unprognostic (1.74e-1)" "unprognostic (5.12e-2)" "unprognostic (2.23e-2)" "unprognostic (2.24e-1)" "unprognostic (1.89e-1)" "unprognostic (7.72e-2)" "unprognostic (3.26e-1)" "unprognostic (4.00e-1)" "unprognostic (2.96e-2)" "unprognostic (1.05e-3)" 7.4 4.9 5.2 7.9 6.0 5.5 5.8 5.7 7.0 8.4 5.6 5.9 5.7 7.5 5.4 6.1 6.2 5.7 5.6 4.9 5.7 6.4 5.0 6.2 11.5 6.3 5.6 6.8 4.4 6.4 5.2 5.9 6.5 6.6 6.7 5.1 5.5 7.1 3.4 5.9 7.9 6.7 6.1 10.4 5.8 7.3 5.6 10.4 8.9 5.5 11.0 6.8 7.8 7.6 12.7 5.0 15.1 8.3 5.9 8.7 19.0 19.9 15.7 18.2 16.9 10.8 9.2 24.3 11.5 8.3 16.4 10.7 24.7 9.3 21.2 18.6 9.1 10.6 10.5 7.9 9.0 23.1 12.0 7.1 19.3 19.6 12.0 10.3 17.8 15.9 14.0 33.8 14.3 5.7 16.0 7.4 9.2 10.5 8.2 12.5 13.6 16.7 8.9 7.0 27.6 12.8 16.2 9.3 18.6 11.6 10.8 14.8 11.1 21.9 28.9 19.4 26.3 16.1 47.6 15.7 14.1 15.5 23.8 18.6 2.7 7.3 6.1 2.6 7.0 6.2 7.0 8.5 1.9 7.3 8.5 7.9 10.0 5.9 2.2 3.8 8.8 4.9 5.2 6.0 5.7 7.0 4.9 5.7 6.3 5.6 6.5 6.1 5.6 7.6 24.3 12.8 8.2 8.5 21.1 4.8 13.6 6.5 10.8 9.6 7.6 7.4 3.8 10.0 10.3 3.7 14.6 7.5 13.7 10.1 0.0 5.9 6.9 7.5 9.1 10.0 2.4 11.0 17.0 7.3 9.4 7.3 12.2 7.4 7.0 10.3 11.4 4.9 6.0 8.4 20.3 7.6 4.1 7.0 6.5 3.3 12.8 7.0 3.6 14.0 4.5 6.6 13.4 18.1 25.8 8.3 4.0 10.9 15.0 10.8 10.1 5.1 12.0 6.5 13.1 8.3 6.8 30.5 21.8 9.0 4.8 10.4 18.3 8.5 6.2 19.4 MEX3C "FLJ38871, RKHD2, RNF194" ENSG00000176624 "Mex-3 RNA binding family member C" Q5U5Q3 18 51174550-51218333 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" "RNA-binding, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 118.4" "Group enriched" "Detected in many" 6 "Early spermatids: 555.3;Late spermatids: 514.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 9.7" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040603 Uncertain Approved Vesicles "Intracellular and membrane" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 23: Testis - Cell cycle regulation" "Cluster 30: Epithelial cell lines - Translation" "Cluster 34: Spermatids - Unknown function" Vesicles "HPA040603: AB_10805714" "unprognostic (1.09e-1)" "unprognostic (2.90e-2)" "unprognostic (8.88e-2)" "unprognostic (8.88e-3)" "unprognostic (2.04e-1)" "unprognostic (7.30e-2)" "prognostic unfavorable (8.49e-5)" "unprognostic (4.34e-2)" "unprognostic (4.43e-1)" "unprognostic (1.05e-2)" "unprognostic (1.03e-2)" "unprognostic (6.75e-2)" "unprognostic (7.99e-2)" "unprognostic (1.82e-1)" "unprognostic (1.48e-1)" "unprognostic (8.01e-2)" "unprognostic (3.17e-1)" 17.6 13.5 9.1 17.0 9.9 49.4 17.4 12.5 12.3 16.4 9.0 13.5 12.6 17.6 10.4 15.5 14.0 18.6 10.8 10.5 9.8 11.9 14.0 13.7 23.6 10.5 10.0 23.5 14.7 17.9 1.7 16.1 10.6 11.5 14.1 14.8 9.6 12.2 9.7 9.2 13.4 20.1 10.7 22.3 13.3 118.4 9.3 40.9 16.1 17.1 26.6 20.2 2.4 11.6 23.8 19.6 71.2 26.8 27.7 36.8 49.6 32.8 37.4 18.9 22.2 33.6 17.3 53.0 13.2 44.2 30.4 44.6 27.9 42.7 31.0 43.0 12.5 10.7 19.1 29.0 44.5 75.2 22.3 28.2 46.5 26.9 76.4 47.0 41.8 36.0 11.3 95.7 40.0 18.0 63.8 24.3 32.1 13.3 15.0 61.7 36.5 46.7 31.1 9.5 34.8 39.1 30.4 12.4 117.7 54.3 13.5 34.3 43.2 46.3 30.9 15.1 28.1 64.5 12.4 87.2 32.9 31.3 110.7 9.7 1.2 1.5 2.3 1.0 2.0 1.9 2.4 2.4 1.4 1.1 0.9 2.3 0.4 3.4 0.7 1.1 2.0 1.4 9.1 9.9 12.5 12.3 10.5 9.8 10.5 10.0 10.6 10.7 9.3 11.6 25.2 19.2 5.0 6.8 18.6 38.2 10.3 12.4 11.4 12.6 25.9 23.2 14.5 14.3 11.2 3.7 20.9 5.2 56.6 9.0 5.9 12.1 555.3 18.9 22.7 30.0 6.7 7.4 8.0 8.5 7.0 18.2 6.1 34.9 12.7 79.3 10.4 7.6 7.7 11.8 7.9 9.4 12.2 10.9 20.5 514.0 16.1 13.8 19.6 5.6 8.2 10.0 34.0 14.1 13.3 16.5 3.9 15.1 20.6 15.4 9.1 9.3 6.4 14.8 0.0 30.2 17.7 14.4 14.2 18.1 45.9 4.2 24.2 14.9 11.5 19.6 MFNG ENSG00000100060 "MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" O00587 22 37469063-37486393 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Developmental protein, Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 69.1" "Cell type enhanced" "Detected in many" "Adipocytes: 51.4;dendritic cells: 54.6;Endothelial cells: 37.1;Hepatic stellate cells: 53.2;Kupffer cells: 45.8;monocytes: 40.6;NK-cells: 72.1;T-cells: 51.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "Daudi: 174.6;HEL: 143.4;HL-60: 220.9;HMC-1: 266.9;HUVEC TERT2: 232.9;TIME: 134.7;U-698: 166.8;U-937: 201.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA048936, HPA056479" Approved Approved Vesicles "Intracellular and membrane" NA NA 74000 "Cluster 27: Non-specific - Gene expression" "Cluster 16: Immune cells - Immune response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 63: NK-cells & T-cells - Immune response" Vesicles "HPA048936: AB_2680564, HPA056479: " "unprognostic (1.21e-1)" "unprognostic (4.17e-3)" "prognostic unfavorable (5.12e-4)" "prognostic favorable (1.65e-4)" "unprognostic (6.41e-3)" "unprognostic (1.00e-2)" "unprognostic (2.64e-1)" "unprognostic (2.36e-2)" "unprognostic (4.64e-2)" "unprognostic (2.91e-2)" "unprognostic (5.44e-2)" "unprognostic (1.42e-1)" "prognostic unfavorable (3.31e-5)" "unprognostic (2.67e-1)" "unprognostic (4.03e-2)" "unprognostic (3.86e-2)" "unprognostic (1.43e-1)" 22.2 7.1 8.9 37.0 8.9 40.3 14.8 8.4 10.8 8.9 6.4 10.5 8.6 9.7 2.4 7.5 11.0 14.5 14.6 7.9 9.2 9.5 7.1 26.3 69.1 18.1 10.8 3.1 3.9 2.6 3.1 30.3 20.5 6.6 7.8 0.7 5.4 5.7 7.5 5.0 24.0 11.5 10.2 58.9 8.6 2.9 11.0 50.5 9.6 8.8 42.5 13.9 6.2 10.3 6.0 2.2 0.2 0.0 0.2 0.5 0.0 0.0 0.0 0.0 0.2 7.1 3.0 174.6 0.7 0.0 0.8 10.8 45.1 8.7 0.2 81.6 1.0 143.4 0.6 1.5 0.6 220.9 266.9 0.0 2.6 1.7 3.2 0.9 232.9 69.0 0.7 73.8 0.0 1.5 27.8 3.0 0.4 6.1 1.0 67.0 1.8 128.7 0.4 0.1 94.1 0.9 0.5 0.3 0.3 0.8 1.3 14.1 134.7 0.0 5.8 22.8 0.6 0.4 0.4 166.8 1.1 201.1 2.7 210.3 198.9 386.5 196.1 196.1 214.5 103.0 222.7 206.1 204.1 113.5 243.4 209.9 127.9 217.1 218.7 51.7 284.3 314.0 8.9 8.9 8.4 10.8 7.9 9.2 18.1 10.8 20.5 10.2 11.0 10.3 51.4 0.0 3.8 0.0 35.4 3.7 0.4 0.2 0.0 6.3 1.0 1.3 1.6 5.7 3.1 0.0 0.0 0.3 54.6 1.1 0.0 2.9 0.2 0.4 0.2 37.1 1.2 30.1 0.1 0.9 0.3 1.1 2.0 1.0 31.6 0.1 53.2 1.5 31.9 0.0 0.1 2.1 0.0 45.8 20.2 0.3 0.0 33.5 3.6 6.5 40.6 0.1 72.1 0.0 0.0 3.7 4.0 0.0 35.0 0.5 2.3 0.3 0.1 0.6 0.0 1.6 1.0 0.1 0.7 0.3 2.4 0.7 51.0 0.1 0.8 0.4 MGAT1 "GLCNAC-TI, GLYT1, GNT-1, GnTI, MGAT" ENSG00000131446 "Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase" P26572 5 180784780-180815652 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Extravillous trophoblasts: 280.2;Syncytiotrophoblasts: 384.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017432 Approved NA NA 12000000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 18: Non-specific - Mitochondria" "Cluster 44: HDLM-2 - Immune response" "Cluster 41: Macrophages - Immune response" "HPA017432: AB_1853851" "unprognostic (1.12e-1)" "unprognostic (1.34e-2)" "unprognostic (3.38e-2)" "unprognostic (2.11e-1)" "unprognostic (3.91e-2)" "unprognostic (6.70e-2)" "unprognostic (4.39e-2)" "unprognostic (9.34e-2)" "unprognostic (2.00e-1)" "unprognostic (2.98e-1)" "unprognostic (3.70e-3)" "unprognostic (6.44e-2)" "prognostic unfavorable (8.65e-4)" "unprognostic (4.15e-2)" "unprognostic (3.52e-2)" "unprognostic (5.68e-2)" "unprognostic (5.00e-2)" 130.4 66.7 44.0 65.8 43.8 60.6 113.7 40.7 59.9 70.7 64.6 69.8 50.2 75.2 28.2 103.2 85.8 39.9 103.2 38.4 42.0 63.3 146.9 113.3 68.5 56.7 43.2 75.1 115.3 20.3 61.7 67.3 54.0 75.5 30.1 29.2 82.0 37.1 61.1 73.4 82.2 40.9 47.4 139.9 78.1 36.4 64.9 38.3 96.1 35.6 42.2 85.0 72.3 49.3 58.3 58.2 30.9 66.3 149.6 68.7 111.0 130.1 154.4 77.4 96.7 79.4 45.6 50.2 77.3 122.3 78.2 68.8 17.0 190.8 46.1 271.6 47.6 44.2 34.1 61.7 72.8 40.6 137.6 79.7 91.5 63.1 62.9 53.6 67.9 34.2 26.1 84.7 70.9 78.3 38.9 55.2 29.6 37.5 72.0 46.2 44.5 66.8 30.9 67.3 27.2 32.1 54.6 56.5 115.7 27.2 43.8 68.5 72.9 94.7 44.7 42.7 61.1 165.9 149.2 44.7 77.6 78.9 49.8 93.0 228.6 104.6 83.5 186.7 91.6 48.3 60.2 70.3 161.7 42.0 51.4 59.1 152.2 70.4 149.4 152.9 75.3 235.1 44.0 43.8 40.7 59.9 38.4 42.0 56.7 43.2 54.0 47.4 64.9 49.3 157.8 48.1 31.1 9.8 57.7 61.2 44.6 52.8 50.1 20.7 41.5 29.7 18.4 44.3 32.7 29.5 56.3 94.9 114.7 43.8 37.2 49.0 31.7 26.2 34.2 94.2 49.8 47.6 7.5 79.0 280.2 80.5 33.6 48.7 30.4 27.2 125.7 88.1 200.5 63.9 8.5 54.9 20.3 195.5 142.1 43.2 62.7 234.9 81.8 26.2 112.1 18.9 87.6 8.0 14.6 54.0 34.7 76.0 169.7 76.9 57.2 22.5 20.4 78.8 32.9 72.1 51.5 26.8 22.5 46.8 63.9 384.9 59.3 43.7 36.7 56.8 MGAT2 GNT-II ENSG00000168282 "Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase" Q10469 14 49620799-49623481 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Congenital disorder of glycosylation, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA043721, HPA056824" Approved Supported "Golgi apparatus" NA Yes 5100000 "Cluster 44: Non-specific - Transcription" "Cluster 14: B-cells - Humoral immune response" "Cluster 29: U-266 - Adaptive immune response" "Cluster 55: Plasma cells - Humoral immune response" "Golgi apparatus" "HPA043721: AB_2678636, HPA056824: AB_2683248" "unprognostic (1.20e-2)" "prognostic unfavorable (3.22e-4)" "unprognostic (2.84e-1)" "unprognostic (5.49e-2)" "unprognostic (1.37e-1)" "unprognostic (1.70e-1)" "unprognostic (3.77e-1)" "unprognostic (1.92e-2)" "unprognostic (1.14e-1)" "unprognostic (7.44e-2)" "unprognostic (7.12e-2)" "unprognostic (5.63e-2)" "unprognostic (2.59e-3)" "unprognostic (9.14e-2)" "unprognostic (3.74e-2)" "unprognostic (4.72e-2)" "unprognostic (2.12e-2)" 16.8 17.6 5.9 24.3 5.8 10.3 13.3 6.9 6.8 17.4 9.0 23.6 23.1 12.7 21.7 11.8 11.9 15.2 11.7 5.6 6.7 14.2 40.7 13.8 25.3 6.4 6.3 13.1 23.8 8.2 7.9 22.0 6.6 14.1 21.9 8.2 15.8 13.7 5.0 9.3 22.5 16.0 6.9 20.2 21.0 24.3 7.2 16.4 13.3 5.6 25.1 20.9 8.8 7.3 63.5 30.7 23.2 39.2 53.6 51.7 15.1 68.6 67.7 62.2 55.8 37.5 47.1 63.7 56.9 62.9 36.0 49.5 32.9 39.7 66.7 65.5 29.1 40.7 21.7 37.2 42.3 94.5 91.2 39.8 31.2 36.8 51.8 45.5 75.5 31.4 31.7 170.4 66.3 24.2 32.9 60.1 23.8 22.2 49.1 36.7 67.1 55.6 49.3 36.2 24.0 25.6 49.3 12.9 39.8 22.2 39.1 63.6 78.9 56.1 60.8 41.1 49.6 182.8 94.6 56.7 27.3 46.5 38.6 49.4 38.6 39.3 36.6 34.1 39.3 25.1 33.3 33.1 39.9 15.9 19.3 26.8 11.6 22.3 39.8 47.2 31.6 44.8 5.9 5.8 6.9 6.8 5.6 6.7 6.4 6.3 6.6 6.9 7.2 7.3 17.4 12.8 8.6 2.0 31.7 15.7 25.7 28.8 14.2 13.7 15.5 8.9 0.1 24.3 18.0 11.0 4.2 26.4 46.9 34.6 9.8 31.0 7.9 12.5 20.7 20.8 12.1 19.0 3.0 34.4 40.3 24.3 13.7 11.7 17.1 27.7 27.1 63.0 37.2 18.5 4.3 20.5 40.7 34.5 28.8 6.0 17.4 26.3 21.4 2.8 40.6 16.7 63.8 6.0 4.5 36.5 25.1 22.2 77.1 27.0 26.7 15.2 23.5 15.8 6.6 15.8 34.6 56.4 13.0 15.2 14.1 5.3 31.5 23.2 20.0 25.5 MGAT3 GNT-III ENSG00000128268 "Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase" Q09327 22 39457012-39492194 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 47.0;intestine: 28.4" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 44.8;Bipolar cells: 30.7;Excitatory neurons: 25.1;Inhibitory neurons: 27.4;Oligodendrocytes: 45.7;Proximal enterocytes: 37.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "basophil: 1.4;eosinophil: 1.1" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "BEWO: 65.1;HMC-1: 56.0;OE19: 58.8;U-266/70: 73.6;U-266/84: 32.6;U-698: 32.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017598 Approved "Intracellular and membrane" NA NA 170000 "Cluster 52: Eosinophils - Transcription" "Cluster 10: Brain - Neuronal signaling" "Cluster 21: OE19 - Mitochondria" "Cluster 45: Enterocytes - Digestion" "HPA017598: AB_1853853" "unprognostic (1.41e-3)" "unprognostic (5.98e-3)" "unprognostic (4.79e-2)" "unprognostic (2.96e-1)" "unprognostic (2.76e-1)" "unprognostic (5.71e-3)" "unprognostic (8.92e-2)" "unprognostic (2.17e-1)" "unprognostic (4.35e-3)" "unprognostic (6.77e-2)" "unprognostic (8.12e-3)" "unprognostic (8.74e-2)" "prognostic unfavorable (5.04e-8)" "unprognostic (6.73e-2)" "unprognostic (1.46e-1)" "unprognostic (5.89e-2)" "unprognostic (4.92e-2)" 7.8 1.1 26.8 4.0 20.9 10.8 6.4 7.6 47.0 6.2 0.0 5.2 21.5 3.8 0.8 1.1 3.4 3.8 4.8 30.3 10.0 3.0 0.2 14.9 7.6 28.1 15.6 1.2 3.1 0.4 1.8 10.5 21.8 1.2 4.6 6.7 1.8 1.0 1.5 2.3 28.4 2.8 4.8 4.8 7.4 5.4 23.9 1.8 1.5 1.8 9.0 1.6 1.5 27.3 0.3 0.4 10.4 1.0 0.0 0.0 65.1 0.5 0.7 0.5 0.0 14.9 3.7 23.4 8.1 0.0 0.2 1.3 5.4 0.0 0.1 0.0 0.5 18.9 0.0 0.2 0.2 0.0 56.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 15.8 2.9 0.0 0.2 0.6 1.4 3.1 58.8 0.0 1.2 0.0 3.9 0.4 0.6 6.0 4.4 0.0 0.0 0.0 18.5 0.8 1.0 0.0 0.1 8.1 0.1 0.1 73.6 32.6 32.6 0.2 0.1 1.7 1.4 0.0 1.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 26.8 20.9 7.6 47.0 30.3 10.0 28.1 15.6 21.8 4.8 23.9 27.3 2.0 44.8 3.0 6.5 2.2 0.4 0.1 1.8 0.0 30.7 0.6 1.1 1.9 1.5 3.7 0.0 6.2 5.5 0.0 4.1 0.0 0.0 19.1 0.9 11.0 2.5 7.8 13.7 25.1 0.2 12.0 2.3 10.2 2.0 2.5 0.0 0.0 0.0 1.5 13.5 27.4 3.8 2.0 0.0 2.3 16.6 4.4 0.9 0.0 0.0 0.1 1.5 0.0 21.6 45.7 1.8 6.1 3.8 1.7 0.3 37.4 1.8 5.2 2.3 6.6 0.3 4.3 0.7 1.2 0.2 0.6 3.7 0.5 0.6 4.5 1.5 MGAT4A "GnT-4a, GnT-Iva" ENSG00000071073 "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A" Q9UM21 2 98619106-98731132 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 96.0" "Cell type enhanced" "Detected in many" "Microglial cells: 175.2;Proximal enterocytes: 132.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BEWO: 127.2;HUVEC TERT2: 48.3;JURKAT: 86.5;TIME: 78.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007608 Enhanced Approved "Golgi apparatus" "Secreted to blood" NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 28: BEWO - Transcription regulation" "Cluster 24: Non-specific - Transcription regulation" "Golgi apparatus" "HPA007608: AB_10602008" "prognostic unfavorable (4.30e-4)" "unprognostic (1.15e-1)" "unprognostic (2.07e-1)" "prognostic unfavorable (6.48e-8)" "unprognostic (1.35e-1)" "unprognostic (2.28e-2)" "unprognostic (3.82e-3)" "unprognostic (1.89e-1)" "unprognostic (3.76e-1)" "unprognostic (3.58e-1)" "unprognostic (2.80e-2)" "unprognostic (2.32e-2)" "unprognostic (4.17e-2)" "unprognostic (1.50e-1)" "unprognostic (4.62e-2)" "unprognostic (4.04e-2)" "unprognostic (2.04e-1)" 11.2 7.8 13.2 20.8 17.8 96.0 12.5 26.1 15.6 8.9 15.1 24.4 29.5 5.8 3.7 6.3 7.0 12.7 7.6 13.1 15.2 27.5 9.7 16.9 21.1 16.4 15.8 3.2 38.8 28.0 9.8 19.6 15.5 7.5 25.5 5.4 25.9 6.4 3.8 4.1 43.8 11.5 18.1 8.1 11.3 6.3 15.5 20.5 8.7 4.7 18.2 13.1 4.7 22.9 8.8 1.7 3.4 7.3 0.0 0.0 127.2 0.0 0.1 0.9 0.0 21.0 10.6 0.0 18.9 0.0 2.4 0.4 7.2 1.0 0.2 10.6 7.9 0.5 0.0 36.7 0.2 17.8 6.4 0.0 4.7 0.0 0.7 0.3 48.3 86.5 1.6 9.2 0.0 17.3 39.3 30.9 1.1 7.6 1.4 9.8 0.0 10.5 24.8 17.6 10.4 3.3 2.5 32.2 4.8 9.2 7.6 23.8 78.8 0.0 4.0 0.1 2.6 3.2 7.6 2.2 0.0 26.7 0.6 7.0 5.1 12.7 20.8 1.0 27.5 3.6 25.2 23.7 3.8 2.5 32.6 27.2 14.0 15.3 2.5 17.1 16.0 12.5 13.2 17.8 26.1 15.6 13.1 15.2 16.4 15.8 15.5 18.1 15.5 22.9 80.8 54.5 25.7 19.2 22.7 9.9 21.1 6.1 11.4 19.8 28.2 15.6 13.4 11.5 17.6 22.0 4.2 6.2 116.9 92.4 21.5 20.8 12.7 14.2 3.8 39.8 53.0 6.3 58.0 29.8 77.9 7.2 19.4 35.1 13.3 5.1 18.9 10.4 57.2 48.8 48.6 41.3 34.6 33.9 18.3 17.5 2.5 54.5 10.6 175.2 21.0 13.4 89.6 36.7 42.0 21.6 58.2 2.2 31.4 17.8 132.4 27.3 7.1 4.8 6.6 6.8 4.9 2.5 7.7 8.6 10.5 14.9 112.2 0.7 40.9 30.2 MGAT4B GnT-Ivb ENSG00000161013 "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B" Q9UQ53 5 179797597-179806952 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 277.1" "Cell type enhanced" "Detected in many" "Distal enterocytes: 224.7;Proximal enterocytes: 224.5;Undifferentiated cells: 131.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 6 "eosinophil: 5.5" "Lineage enriched" "Detected in single" 6 "granulocytes: 5.5" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA012804, HPA052134" Uncertain Approved "Nucleoplasm,Golgi apparatus,Vesicles,Cytosol" "Intracellular and membrane" NA NA 19000 "Cluster 52: Eosinophils - Transcription" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 45: Enterocytes - Digestion" Nucleoplasm "Golgi apparatus, Vesicles, Cytosol" "HPA012804: , HPA052134: AB_2681741" "unprognostic (2.01e-2)" "unprognostic (8.68e-3)" "unprognostic (1.40e-1)" "unprognostic (3.83e-2)" "prognostic unfavorable (6.15e-5)" "unprognostic (3.61e-3)" "unprognostic (7.57e-3)" "unprognostic (1.22e-2)" "unprognostic (2.02e-1)" "unprognostic (5.13e-2)" "unprognostic (2.26e-2)" "unprognostic (2.27e-2)" "prognostic favorable (5.78e-4)" "unprognostic (1.52e-1)" "unprognostic (2.54e-1)" "unprognostic (1.72e-2)" "unprognostic (1.42e-1)" 48.4 105.0 17.2 19.0 16.9 24.6 39.9 16.8 19.3 37.0 18.1 147.0 134.1 36.9 13.4 75.1 37.2 23.5 103.3 18.9 14.2 124.8 277.1 61.2 15.5 16.3 15.0 41.1 63.3 22.9 37.7 17.9 15.1 42.3 65.0 4.4 57.9 11.9 43.8 53.4 168.3 14.9 14.6 52.8 96.3 30.6 18.0 10.5 60.1 14.9 16.0 38.7 42.1 16.2 84.2 85.3 40.8 93.7 117.4 65.1 71.1 48.3 98.3 44.4 34.8 91.7 226.4 14.4 122.3 108.2 193.1 61.6 57.9 110.1 32.2 121.0 33.0 43.5 75.1 78.4 85.9 53.7 13.4 70.5 76.6 44.1 53.0 165.2 89.1 16.9 28.7 38.5 73.6 92.6 8.4 47.4 24.7 123.7 35.1 21.6 31.4 40.4 132.3 158.5 67.5 39.7 73.7 75.2 139.1 33.8 51.3 56.3 109.2 106.6 48.6 61.2 80.2 32.5 39.5 35.4 125.0 68.2 78.7 0.0 0.4 5.5 0.1 0.1 0.0 0.0 0.3 0.1 0.3 0.9 0.2 0.3 0.1 0.0 0.3 0.3 0.0 0.2 17.2 16.9 16.8 19.3 18.9 14.2 16.3 15.0 15.1 14.6 18.0 16.2 35.7 12.8 9.2 9.4 7.7 12.5 17.8 12.5 5.2 15.5 29.6 30.7 24.1 37.1 11.1 27.6 4.2 8.1 22.1 224.7 3.9 66.7 0.7 27.2 17.8 24.3 22.9 5.5 11.4 54.0 11.1 15.3 78.5 50.5 5.1 39.5 26.7 89.9 17.7 30.3 10.0 72.2 14.2 20.7 11.7 2.6 15.2 24.5 10.6 9.4 16.8 25.7 6.2 4.5 6.3 89.9 114.6 17.0 7.0 49.0 224.5 22.4 7.7 11.1 13.1 16.2 24.7 1.5 6.5 21.1 11.9 14.0 12.5 24.9 131.8 64.8 MGAT4C HGNT-IV-H ENSG00000182050 "MGAT4 family member C" Q9UBM8 12 85955666-86838904 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enhanced" "Detected in some" "epididymis: 3.7;pituitary gland: 3.1;testis: 4.7;thyroid gland: 6.2" "Group enriched" "Detected in some" 8 "Astrocytes: 876.3;Excitatory neurons: 988.4;Inhibitory neurons: 1438.9" "Cancer enriched" "Detected in single" 19 "thyroid cancer: 2.6" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 10 "NTERA-2: 6.0;SCLC-21H: 2.5;SuSa: 1.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016418 Approved Approved "Vesicles,Plasma membrane,Centriolar satellite" NA NA "Cluster 68: Epididymis - Unknown function" "Cluster 5: NTERA-2 - Transcription" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Vesicles, Plasma membrane" "Centriolar satellite" "HPA016418: AB_2732416" "unprognostic (5.23e-2)" "unprognostic (2.33e-1)" "unprognostic (1.84e-1)" "unprognostic (3.32e-4)" "unprognostic (1.07e-1)" "unprognostic (9.64e-2)" "unprognostic (5.94e-3)" "unprognostic (1.88e-1)" "unprognostic (8.05e-2)" "unprognostic (1.89e-1)" "unprognostic (6.32e-3)" "unprognostic (3.51e-2)" "unprognostic (6.85e-10)" "unprognostic (3.15e-2)" "unprognostic (1.77e-1)" "unprognostic (1.97e-1)" "unprognostic (4.74e-3)" 0.3 0.8 1.7 0.0 2.0 0.1 0.0 0.2 1.4 0.1 0.0 0.4 0.0 0.0 3.7 0.0 0.1 0.1 1.7 1.0 1.8 0.0 0.1 0.1 0.0 1.0 2.4 0.0 0.1 0.0 3.1 0.0 1.6 0.2 0.1 0.5 0.0 0.6 0.0 0.0 0.1 0.0 1.1 0.0 0.1 4.7 2.3 0.0 6.2 0.0 0.0 0.1 0.1 0.7 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 6.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.0 1.9 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 2.0 0.2 1.4 1.0 1.8 1.0 2.4 1.6 1.1 2.3 0.7 0.1 6.4 1.1 876.3 0.0 0.1 0.2 1.5 0.0 11.2 0.0 0.0 10.4 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 123.9 0.1 0.1 4.2 0.0 0.0 988.4 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1438.9 0.0 4.1 0.0 0.0 98.9 16.1 0.3 0.0 34.7 0.2 0.5 0.0 32.2 17.2 0.4 0.0 4.1 0.0 0.3 0.0 0.1 0.0 1.8 0.0 0.4 0.2 3.8 1.5 0.0 0.1 0.0 0.5 6.2 0.0 0.3 MGAT5 "GNT-V, MGAT5A" ENSG00000152127 "Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase" Q09328 2 134119983-134454621 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 109.5;Inhibitory neurons: 134.5;Microglial cells: 141.5;Oligodendrocyte precursor cells: 124.7;Oligodendrocytes: 495.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA010919 Approved "Intracellular and membrane" NA NA 440000 "Cluster 37: B-cells - Transcription" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "HPA010919: AB_10601864" "unprognostic (1.19e-1)" "unprognostic (2.16e-1)" "unprognostic (5.39e-2)" "unprognostic (6.21e-2)" "unprognostic (3.65e-1)" "unprognostic (3.76e-1)" "unprognostic (4.45e-3)" "unprognostic (3.41e-3)" "unprognostic (5.68e-2)" "unprognostic (8.63e-3)" "unprognostic (1.59e-1)" "unprognostic (2.64e-1)" "unprognostic (5.97e-2)" "unprognostic (1.81e-2)" "unprognostic (9.27e-2)" "unprognostic (2.17e-2)" "unprognostic (1.91e-1)" 9.4 10.4 15.4 15.0 25.2 15.5 7.9 29.6 17.9 9.1 8.5 12.6 16.1 8.8 6.6 9.0 19.0 11.1 39.0 13.3 32.1 15.3 3.7 10.4 24.6 30.5 32.9 12.0 10.9 16.3 6.2 15.1 32.1 8.4 15.0 11.6 14.6 9.4 2.2 6.8 18.1 11.2 18.4 16.2 16.9 7.2 24.2 19.1 11.3 4.6 25.4 13.2 5.0 26.4 27.9 11.0 27.3 19.7 23.8 45.3 19.1 36.4 55.0 14.4 12.0 4.7 13.4 44.3 27.1 29.2 16.4 9.7 21.6 17.0 27.3 43.9 12.7 25.0 13.7 58.0 15.5 24.5 85.1 12.5 17.4 30.3 18.6 19.6 108.7 22.1 13.0 29.6 26.3 17.9 13.3 11.6 12.5 28.9 27.0 16.2 32.3 28.6 11.1 33.7 45.1 55.4 11.7 9.9 69.3 18.3 7.7 16.8 49.5 45.1 24.0 33.1 19.3 8.3 4.1 16.5 37.8 34.4 73.1 0.6 0.4 1.0 0.8 0.3 1.3 3.0 1.5 1.0 0.3 3.7 0.6 0.8 1.1 1.3 0.4 0.9 1.0 0.6 15.4 25.2 29.6 17.9 13.3 32.1 30.5 32.9 32.1 18.4 24.2 26.4 13.2 3.2 2.4 66.6 63.2 8.0 5.7 10.3 8.0 43.6 11.6 9.9 67.3 8.6 8.5 1.8 2.1 3.2 14.9 36.9 0.0 9.0 15.6 22.6 7.6 12.5 7.2 4.4 109.5 9.0 26.3 9.0 37.2 21.0 0.0 23.1 11.7 3.0 15.5 16.8 134.5 20.3 30.5 13.5 9.9 15.1 4.4 12.9 14.2 141.5 5.3 11.4 9.2 124.7 495.5 13.0 13.2 9.4 9.0 9.7 17.6 2.4 22.6 5.2 0.0 8.8 14.3 0.6 6.1 7.3 7.2 5.3 22.4 16.6 9.9 14.5 MGAT5B "FLJ25132, GnT-IX, GnT-VB" ENSG00000167889 "Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B" Q3V5L5 17 76868404-76950393 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 10 "brain: 12.0" "Cell type enhanced" "Detected in some" "Astrocytes: 16.0;Early spermatids: 7.3;Excitatory neurons: 26.2;Inhibitory neurons: 21.9;Late spermatids: 8.1" "Group enriched" "Detected in many" 5 "glioma: 2.6;melanoma: 7.1;testis cancer: 2.4" "Region enhanced" "Detected in many" "cerebral cortex: 12.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A549: 32.1;SCLC-21H: 15.9;U-138 MG: 19.2;U-2 OS: 20.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA011082 Approved "Nucleoplasm,Cytokinetic bridge,Mitotic spindle" Yes No "Cluster 10: Brain - Neuronal signaling" "Cluster 17: WM-115 - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Mitotic spindle" "Cytokinetic bridge" "HPA011082: AB_2668423" "unprognostic (6.37e-2)" "unprognostic (9.16e-3)" "unprognostic (8.51e-2)" "unprognostic (1.43e-3)" "unprognostic (5.68e-3)" "unprognostic (1.33e-1)" "unprognostic (2.28e-3)" "unprognostic (1.52e-3)" "unprognostic (5.30e-2)" "unprognostic (3.89e-2)" "unprognostic (1.68e-1)" "unprognostic (5.67e-2)" "unprognostic (1.46e-7)" "unprognostic (1.66e-1)" "unprognostic (8.09e-3)" "unprognostic (1.04e-1)" "unprognostic (3.01e-1)" 0.2 0.2 2.4 0.2 2.1 0.1 0.1 0.0 12.0 0.2 0.0 0.1 0.0 0.2 0.0 0.1 0.1 0.1 0.0 5.2 0.0 0.2 0.0 0.3 0.1 0.3 0.0 0.2 0.0 0.2 0.9 0.2 0.0 0.0 0.0 0.9 0.1 0.0 0.0 0.1 0.2 0.0 0.0 0.3 0.1 1.2 0.0 0.2 0.2 0.1 0.0 0.1 0.1 0.0 3.7 32.1 6.4 3.4 0.0 0.0 3.7 0.4 1.3 11.7 6.9 0.1 0.7 0.0 2.5 1.5 13.7 0.2 1.6 0.2 3.0 0.1 0.5 0.0 1.7 0.1 0.0 0.0 0.2 0.1 0.2 0.0 1.8 5.2 2.0 0.7 0.2 0.0 0.0 1.5 0.1 0.0 1.8 0.8 3.5 4.8 5.6 7.1 8.9 0.1 15.9 6.1 5.5 2.4 5.0 0.4 0.2 0.2 5.8 19.2 20.9 0.3 6.3 0.0 0.0 0.7 0.6 0.0 14.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 2.1 0.0 12.0 5.2 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 16.0 0.1 0.1 0.1 0.0 0.0 5.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.3 0.1 0.1 0.8 0.0 0.0 26.2 0.0 3.2 0.2 0.0 0.2 0.0 0.6 0.7 0.0 0.1 0.0 21.9 0.0 0.0 0.0 0.0 8.1 0.6 0.0 0.0 2.8 0.0 0.2 0.0 5.0 1.0 0.0 0.0 0.4 0.0 0.0 0.0 0.1 0.0 1.8 0.0 0.0 0.1 1.1 2.4 0.0 0.0 0.1 0.1 0.2 0.0 0.0 MGMT ENSG00000170430 "O-6-methylguanine-DNA methyltransferase" P16455 10 129467190-129770983 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair" "DNA-binding, Methyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 89.3" "Cell type enhanced" "Detected in all" "Hepatocytes: 465.7;Proximal tubular cells: 340.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "MCF7: 60.0" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" "CAB002786, HPA032135, HPA032136, HPA069497, CAB069881" Supported Enhanced Nucleoplasm NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 85: Liver - Metabolism" "Cluster 39: CACO-2 - Unknown function" "Cluster 2: Hepatocytes - Metabolism" Nucleoplasm "CAB002786: , CAB069881: AB_10002128, HPA032135: AB_2674171, HPA032136: AB_2674172, HPA069497: AB_2732134" "unprognostic (1.10e-1)" "prognostic favorable (9.42e-4)" "unprognostic (1.48e-1)" "unprognostic (5.81e-2)" "unprognostic (7.84e-3)" "unprognostic (1.67e-1)" "prognostic favorable (1.54e-4)" "unprognostic (6.54e-3)" "unprognostic (4.71e-2)" "unprognostic (2.03e-1)" "unprognostic (1.26e-1)" "unprognostic (6.32e-1)" "unprognostic (4.89e-1)" "unprognostic (2.75e-1)" "unprognostic (1.95e-1)" "unprognostic (1.66e-1)" "unprognostic (1.08e-1)" 21.5 17.0 14.7 10.3 15.1 12.7 20.4 14.8 18.6 13.9 16.6 14.7 16.9 13.3 8.1 15.9 23.7 19.6 18.5 14.1 14.5 23.5 89.3 11.7 19.4 15.9 15.4 16.9 26.5 12.3 9.5 6.8 16.0 15.0 5.0 3.9 22.7 7.8 25.5 17.1 15.3 8.0 14.7 14.3 18.2 15.2 15.0 23.2 16.3 16.0 11.1 18.4 13.8 15.2 0.0 7.0 7.1 35.2 14.9 30.9 27.1 15.6 17.0 10.9 10.7 44.0 45.6 33.0 24.6 20.2 0.0 20.8 4.5 16.4 4.6 0.0 2.7 6.6 16.2 28.6 22.7 0.7 17.8 19.7 0.0 6.6 0.0 0.0 0.1 53.5 0.1 22.0 14.0 60.0 26.1 34.0 1.6 29.9 27.8 29.3 0.1 12.7 20.7 16.0 7.2 18.0 18.3 7.7 0.0 5.5 29.8 25.3 0.0 14.6 7.1 0.1 0.0 0.0 0.0 17.1 0.0 10.8 0.0 9.6 37.2 17.1 43.9 39.2 43.6 49.7 40.4 42.0 39.0 48.2 39.6 42.8 4.6 49.5 37.2 43.7 54.0 42.1 14.7 15.1 14.8 18.6 14.1 14.5 15.9 15.4 16.0 14.7 15.0 15.2 106.0 12.8 19.0 32.0 59.2 51.2 80.6 91.5 49.5 17.4 69.0 112.9 49.3 94.4 48.7 103.0 8.4 51.3 51.1 55.6 127.2 50.0 107.6 138.0 29.6 70.4 54.5 48.2 28.5 58.7 67.0 59.2 31.1 34.1 64.7 93.9 108.1 465.7 89.7 15.2 16.9 73.1 50.8 75.0 48.7 140.6 67.4 44.6 65.8 62.8 56.4 37.2 78.2 23.1 30.7 82.4 57.9 55.3 37.0 47.1 108.4 340.3 102.5 45.6 46.0 48.6 70.6 45.3 81.4 46.9 42.6 26.8 52.5 87.4 63.8 75.2 MGRN1 "KIAA0544, RNF156" ENSG00000102858 "Mahogunin ring finger 1" O60291 16 4616493-4690974 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 16.2" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007653, HPA008033" Approved Supported "Endoplasmic reticulum,Vesicles" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 18: Non-specific - Mitochondria" "Cluster 18: U-2197 - ECM organization" "Cluster 52: Non-specific - Transcription" Vesicles "Endoplasmic reticulum" "HPA007653: AB_1846304, HPA008033: " "unprognostic (2.27e-1)" "unprognostic (1.09e-1)" "unprognostic (1.18e-1)" "unprognostic (1.04e-2)" "unprognostic (1.06e-1)" "unprognostic (1.97e-2)" "unprognostic (4.24e-1)" "unprognostic (1.26e-2)" "unprognostic (9.96e-2)" "unprognostic (1.70e-1)" "unprognostic (4.03e-2)" "unprognostic (9.47e-2)" "unprognostic (6.41e-2)" "unprognostic (2.32e-1)" "unprognostic (9.06e-2)" "unprognostic (1.79e-1)" "unprognostic (5.04e-2)" 23.3 34.3 18.6 25.0 20.6 32.6 22.8 11.9 25.4 28.3 4.9 30.6 28.9 36.9 6.8 20.4 32.1 19.7 26.9 26.4 11.4 24.0 53.5 30.3 18.1 14.1 10.4 30.5 34.6 18.5 33.2 18.5 8.8 30.1 10.9 9.0 25.6 20.5 52.1 23.0 29.9 17.5 8.1 37.7 35.3 18.0 12.0 11.7 28.8 16.7 10.9 28.2 20.6 24.3 13.6 63.9 32.4 33.2 19.0 18.4 44.0 28.7 20.0 23.6 20.0 42.5 31.4 40.0 36.2 35.0 17.6 21.4 26.0 23.6 7.0 56.0 28.8 22.0 45.2 59.6 34.7 32.1 52.3 34.2 15.0 33.0 14.1 17.0 23.0 26.0 32.7 28.6 16.4 59.7 33.3 42.9 48.0 19.2 27.4 60.7 17.0 54.3 20.8 39.3 51.8 42.8 47.6 50.6 28.2 14.8 30.7 31.4 40.8 43.7 24.1 124.3 25.0 44.6 37.8 27.2 18.6 31.8 32.0 5.4 3.5 3.8 2.5 3.9 2.3 1.3 1.4 2.3 2.4 1.5 3.2 1.9 16.2 1.4 2.6 4.1 1.7 3.7 18.6 20.6 11.9 25.4 26.4 11.4 14.1 10.4 8.8 8.1 12.0 24.3 14.7 25.6 34.0 24.2 22.2 9.2 29.5 10.0 6.2 27.3 15.8 11.0 11.4 22.8 9.6 18.4 43.8 23.5 28.2 27.7 5.9 18.6 16.2 20.1 24.2 16.9 37.0 13.7 26.6 22.7 17.7 19.0 44.9 24.5 14.0 30.4 15.0 34.8 30.4 25.2 25.0 23.5 4.1 30.1 21.4 27.2 26.8 27.0 21.4 8.4 36.5 20.8 23.7 18.6 29.8 32.0 15.8 24.8 29.0 23.7 31.7 13.9 11.1 35.2 0.0 20.4 17.6 9.3 12.5 11.9 16.3 34.2 24.0 29.8 23.1 27.8 MGST1 "GST12, MGST-I" ENSG00000008394 "Microsomal glutathione S-transferase 1" P10620 12 16347142-16609259 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adipose tissue: 1096.9;adrenal gland: 1137.3;liver: 3104.7" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 1205.9;Club cells: 1308.7;Hepatocytes: 4345.6;Proximal tubular cells: 1265.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "classical monocyte: 170.2;myeloid DC: 123.5" "Group enriched" "Detected in many" 13 "dendritic cells: 123.5;monocytes: 170.2" "Cell line enhanced" "Detected in many" "ASC diff: 5391.4;ASC TERT1: 2078.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044840 Enhanced Approved "Endoplasmic reticulum,Mitochondria" NA NA 19000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 85: Liver - Metabolism" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Mitochondria "Endoplasmic reticulum" "HPA044840: AB_10965550" "unprognostic (4.57e-2)" "unprognostic (4.80e-3)" "unprognostic (5.82e-2)" "unprognostic (2.92e-3)" "unprognostic (3.97e-3)" "unprognostic (1.03e-1)" "unprognostic (8.19e-2)" "unprognostic (1.03e-1)" "unprognostic (4.82e-2)" "unprognostic (3.42e-1)" "unprognostic (1.37e-3)" "unprognostic (2.20e-1)" "prognostic unfavorable (7.45e-4)" "unprognostic (9.90e-2)" "unprognostic (4.61e-1)" "prognostic favorable (1.97e-4)" "unprognostic (4.19e-1)" 1096.9 1137.3 139.2 76.1 143.9 79.3 574.8 131.4 200.7 69.7 111.9 315.5 128.9 32.7 43.9 195.3 78.4 200.8 135.1 133.9 165.4 392.9 3104.7 177.2 3.5 156.5 155.7 11.4 131.3 0.8 52.6 14.2 166.6 161.2 212.8 7.0 155.3 55.8 25.5 88.8 119.5 44.7 146.4 7.3 131.4 20.2 147.5 14.0 272.3 43.3 7.7 267.9 114.7 132.9 1.4 495.2 115.6 139.4 5391.4 2078.4 1.5 408.5 418.5 220.6 339.1 186.0 838.6 0.4 48.5 535.8 694.2 2.4 317.0 663.5 202.9 1.1 41.4 175.7 256.6 664.8 1252.0 350.4 1.2 1375.9 714.7 671.2 710.5 540.4 393.1 0.1 126.7 0.6 486.3 101.2 0.3 137.0 987.6 0.7 391.2 0.4 69.3 229.3 503.3 982.1 21.8 17.1 645.8 411.8 17.5 630.1 442.5 190.8 248.0 226.1 30.5 447.3 541.1 0.6 1.7 1.5 748.1 538.5 7.1 11.3 170.2 1.8 0.1 26.3 0.5 1.0 0.2 0.1 123.5 0.0 0.1 0.1 5.9 0.2 5.9 34.1 1.1 55.9 139.2 143.9 131.4 200.7 133.9 165.4 156.5 155.7 166.6 146.4 147.5 132.9 39.6 266.0 651.3 130.2 14.0 25.6 130.2 1205.9 91.0 0.0 383.8 262.6 5.1 574.7 1308.7 71.7 0.0 2.9 9.8 288.1 181.9 26.9 25.4 299.9 198.2 19.6 45.6 92.8 4.4 434.1 218.1 404.5 153.9 947.9 34.1 26.3 67.5 4345.6 160.2 0.0 0.5 280.5 740.6 176.4 52.0 17.9 33.2 75.7 39.2 6.5 224.4 1.0 5.2 1.0 0.8 322.7 175.0 113.2 6.0 467.2 209.5 1265.6 526.1 1.3 0.0 11.3 124.3 0.7 2.3 510.3 17.6 7.9 22.1 152.4 534.1 883.3 MGST2 MGST-II ENSG00000085871 "Microsomal glutathione S-transferase 2" Q99735 4 139665768-139740745 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Leukotriene biosynthesis, Lipid metabolism" "Lyase, Oxidoreductase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 393.2" "Cell type enhanced" "Detected in all" "Proximal enterocytes: 441.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "plasmacytoid DC: 194.6" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "CAPAN-2: 276.3;OE19: 558.9" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA010690, HPA010707" Enhanced Uncertain "Endoplasmic reticulum,Cytosol" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 21: OE19 - Mitochondria" "Cluster 22: Epithelial cell types - Mixed function" Cytosol "Endoplasmic reticulum" "HPA010690: , HPA010707: AB_1853922" "unprognostic (9.35e-2)" "unprognostic (6.13e-2)" "unprognostic (4.33e-2)" "prognostic favorable (5.26e-5)" "unprognostic (1.58e-1)" "unprognostic (8.26e-2)" "unprognostic (1.02e-2)" "unprognostic (1.18e-1)" "unprognostic (4.38e-2)" "unprognostic (2.77e-2)" "unprognostic (8.78e-2)" "unprognostic (6.41e-2)" "prognostic favorable (3.22e-9)" "unprognostic (4.10e-1)" "unprognostic (9.91e-2)" "unprognostic (1.77e-2)" "unprognostic (1.01e-2)" 61.8 92.7 43.5 30.4 42.9 42.6 66.6 45.1 60.6 63.6 54.8 112.5 132.5 39.2 82.1 177.6 70.8 87.6 118.3 42.6 45.7 99.2 393.2 49.0 36.0 46.6 44.6 26.3 66.2 102.0 44.6 75.6 46.5 74.9 121.2 7.8 90.6 50.0 104.2 97.1 143.5 57.4 46.6 60.5 72.5 50.6 45.3 35.1 45.8 118.4 64.6 86.7 78.4 48.9 40.8 58.5 28.7 0.3 4.8 15.4 17.7 7.2 66.1 3.2 10.7 62.3 276.3 0.1 158.2 17.5 13.6 74.8 52.7 81.2 4.9 22.3 47.7 174.9 57.3 251.5 13.3 152.7 130.0 53.0 197.2 2.1 12.5 63.9 166.3 0.3 75.9 25.7 23.3 33.9 0.2 24.7 6.5 558.9 59.4 12.7 33.4 54.0 153.0 87.4 71.9 21.6 53.2 83.2 64.8 2.0 52.9 202.2 104.9 5.6 27.3 7.8 6.4 29.7 22.5 9.7 3.8 254.8 12.6 43.8 103.8 30.4 4.1 64.8 2.9 1.3 7.6 3.5 147.0 2.4 2.3 2.6 17.7 26.4 22.2 194.6 37.7 39.4 43.5 42.9 45.1 60.6 42.6 45.7 46.6 44.6 46.5 46.6 45.3 48.9 327.9 25.6 36.6 5.5 7.7 61.1 295.9 316.7 75.7 7.8 99.1 57.3 100.5 205.9 185.5 95.6 25.0 85.3 71.0 168.3 90.1 121.0 6.3 132.5 27.1 238.4 121.8 60.2 19.4 138.6 62.8 31.8 90.2 172.9 43.2 56.9 203.1 419.3 378.1 6.7 24.2 215.1 170.9 107.8 77.8 12.8 44.4 85.3 39.2 49.6 83.6 14.1 27.8 11.6 4.7 121.8 213.1 33.4 7.1 94.6 441.1 277.2 126.6 3.5 13.1 44.6 49.6 4.6 15.1 264.0 124.9 67.2 15.2 43.6 258.2 344.9 MIB1 "DIP-1, KIAA1323, MIB, ZZANK2, ZZZ6" ENSG00000101752 "Mindbomb E3 ubiquitin protein ligase 1" Q86YT6 18 21704957-21870953 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Notch signaling pathway, Ubl conjugation pathway" Transferase "Cardiomyopathy, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Oligodendrocyte precursor cells: 121.2;Oligodendrocytes: 109.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in all" "REH: 121.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019100, CAB037044" Approved Supported "Vesicles,Plasma membrane" NA NA "Cluster 10: Basophils - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 14: REH - Unknown function" "Cluster 44: Endometrium - Transcription" "Plasma membrane" Vesicles "CAB037044: AB_1841007, HPA019100: AB_1853934" "unprognostic (1.38e-1)" "unprognostic (6.92e-2)" "unprognostic (7.29e-2)" "unprognostic (6.99e-2)" "unprognostic (5.66e-2)" "unprognostic (3.23e-2)" "unprognostic (8.45e-3)" "unprognostic (2.70e-1)" "unprognostic (5.42e-2)" "unprognostic (4.69e-2)" "unprognostic (3.78e-2)" "unprognostic (4.70e-2)" "unprognostic (8.33e-3)" "unprognostic (4.91e-3)" "unprognostic (1.73e-1)" "unprognostic (4.86e-2)" "unprognostic (1.85e-2)" 8.1 6.3 9.1 6.0 9.1 4.9 11.2 9.2 8.5 11.0 8.0 7.1 5.1 13.0 9.5 8.0 7.1 8.6 6.0 8.4 9.2 11.1 10.4 7.2 7.6 9.5 10.2 11.7 8.1 9.8 5.2 11.0 8.6 10.1 7.0 8.3 8.4 8.5 5.8 9.1 5.2 10.2 10.1 7.2 7.6 8.7 10.3 11.5 13.6 7.0 7.9 8.4 8.2 9.6 19.9 7.6 36.4 25.8 19.5 23.0 9.0 15.6 17.2 10.8 15.6 11.3 7.1 16.9 14.1 21.4 11.8 13.2 21.4 21.0 24.4 22.4 10.4 18.8 9.7 15.9 15.8 38.3 7.8 14.8 23.0 12.6 32.0 16.0 27.8 6.6 26.5 47.5 17.2 9.5 18.9 14.7 9.5 12.2 10.2 121.1 30.3 42.5 18.7 16.9 12.1 30.1 26.8 12.4 13.9 18.6 8.8 25.1 23.9 27.8 14.2 11.7 21.1 25.6 9.5 25.4 11.8 24.1 16.9 0.7 0.3 0.1 0.2 0.1 0.2 0.2 0.3 0.2 0.1 0.1 0.2 0.1 0.3 0.5 0.1 0.2 0.4 0.1 9.1 9.1 9.2 8.5 8.4 9.2 9.5 10.2 8.6 10.1 10.3 9.6 35.7 48.1 22.7 68.2 11.9 21.9 15.1 19.8 24.5 28.8 24.1 19.7 18.1 25.8 31.8 16.5 25.0 13.3 18.2 20.8 3.9 13.4 7.0 29.0 59.2 30.8 24.0 23.1 106.7 12.9 7.5 33.1 10.2 32.4 14.5 16.8 24.3 30.0 12.9 15.2 92.6 17.1 26.4 17.2 16.2 5.6 20.5 14.2 26.6 67.5 19.4 17.7 15.5 121.2 109.6 18.8 7.0 24.8 18.1 48.5 8.7 15.9 30.6 14.5 0.0 35.4 26.9 26.2 12.0 23.4 24.6 25.3 14.5 21.8 10.4 25.3 MIB2 "FLJ39787, skeletrophin, ZZANK1, ZZZ5" ENSG00000197530 "Mindbomb E3 ubiquitin protein ligase 2" Q96AX9 1 1615415-1630610 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Notch signaling pathway, Ubl conjugation pathway" "Actin-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 44.0" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 130.9;Late spermatids: 242.0;Suprabasal keratinocytes: 126.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HaCaT: 15.2;SCLC-21H: 15.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA068322 Enhanced NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 59: Non-specific - Translation" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 63: NK-cells & T-cells - Immune response" "HPA068322: AB_2685973" "unprognostic (3.93e-2)" "unprognostic (6.02e-2)" "unprognostic (2.34e-2)" "unprognostic (6.60e-2)" "unprognostic (2.08e-1)" "unprognostic (1.70e-2)" "unprognostic (7.36e-3)" "unprognostic (2.61e-1)" "unprognostic (1.54e-1)" "unprognostic (6.57e-2)" "unprognostic (1.15e-3)" "unprognostic (3.17e-2)" "unprognostic (2.22e-3)" "unprognostic (1.29e-1)" "unprognostic (3.58e-2)" "unprognostic (2.49e-1)" "unprognostic (1.01e-2)" 4.5 7.3 2.8 1.1 2.4 0.9 3.9 0.4 7.7 7.6 2.8 7.5 1.2 6.8 0.1 19.9 7.0 0.4 16.4 3.4 2.8 8.5 9.6 4.1 0.4 6.0 0.3 8.3 8.7 0.8 15.6 0.5 0.7 6.8 0.4 0.4 5.7 1.5 44.0 18.9 5.7 0.4 0.0 6.5 6.6 9.6 0.6 0.5 6.2 2.2 0.0 7.3 7.1 1.5 7.6 1.1 0.5 1.7 1.9 0.7 10.2 3.5 1.6 1.1 2.5 1.5 1.9 0.8 4.9 1.0 0.5 15.2 0.5 2.3 0.0 4.0 6.3 0.6 2.5 1.5 2.6 1.0 2.5 1.5 1.6 0.7 0.2 0.7 0.6 3.4 3.1 1.3 0.3 1.2 4.2 9.7 1.3 1.9 11.8 7.1 2.1 10.8 0.1 0.9 15.7 5.7 5.9 0.8 6.5 0.3 1.1 3.7 0.7 1.0 2.4 5.7 1.0 7.6 2.4 2.2 2.6 3.1 1.3 0.0 0.1 1.7 3.2 0.1 3.2 2.6 2.4 3.5 0.0 3.3 2.9 2.2 0.3 6.3 0.0 7.3 2.0 0.8 2.8 2.4 0.4 7.7 3.4 2.8 6.0 0.3 0.7 0.0 0.6 1.5 15.2 0.0 8.4 21.5 20.0 130.9 16.2 17.1 86.0 35.1 18.5 18.4 11.2 18.6 11.3 23.9 12.5 11.1 61.2 50.8 9.8 7.9 75.9 19.0 12.2 12.1 15.0 5.7 18.5 1.3 10.3 16.0 34.7 13.1 20.3 32.5 17.5 10.6 6.6 26.9 13.5 35.7 8.2 11.6 22.2 242.0 21.1 12.4 17.8 4.7 8.9 30.0 110.2 10.1 11.9 5.8 50.3 15.8 19.5 12.1 44.6 20.8 10.2 35.7 0.0 17.0 20.1 22.3 45.6 85.6 126.0 15.1 43.3 20.6 38.2 18.3 MID1 "FXY, OS, RNF59, TRIM18" ENSG00000101871 "Midline 1" O15344 X 10445310-10833654 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 129.3;Basal squamous epithelial cells: 82.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A549: 156.1;AF22: 132.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA002878, HPA003715" Approved Uncertain "Golgi apparatus,Centriolar satellite,Cytosol" NA NA "Cluster 17: Basophils - Unknown function" "Cluster 57: Non-specific - Angiogenesis" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 64: Astrocytes - Nervous system maintenance" "Centriolar satellite" "Golgi apparatus, Cytosol" "HPA002878: , HPA003715: AB_1079384" "unprognostic (1.99e-1)" "unprognostic (2.81e-1)" "unprognostic (4.66e-2)" "unprognostic (2.79e-1)" "unprognostic (2.78e-1)" "unprognostic (2.61e-1)" "prognostic unfavorable (3.06e-4)" "unprognostic (1.19e-1)" "unprognostic (3.61e-1)" "unprognostic (2.09e-1)" "unprognostic (2.87e-1)" "unprognostic (9.43e-2)" "unprognostic (1.25e-3)" "unprognostic (9.89e-2)" "unprognostic (1.49e-1)" "unprognostic (1.12e-3)" "unprognostic (5.88e-2)" 5.9 2.5 6.9 5.0 7.7 1.7 5.3 17.2 5.0 7.0 6.5 17.3 5.7 8.9 4.9 7.0 6.4 6.8 9.3 7.0 4.9 7.3 4.2 6.5 2.2 3.6 10.4 4.4 3.5 2.8 4.2 6.2 4.9 10.4 10.6 12.3 4.9 12.9 0.7 2.9 5.8 12.3 2.1 1.0 3.8 3.6 8.2 2.3 4.2 2.2 3.1 11.7 6.2 4.4 33.2 156.1 132.5 16.7 8.1 9.2 14.6 16.2 17.8 19.7 20.7 31.0 9.7 10.6 6.5 21.9 58.4 22.5 11.0 15.1 23.0 1.3 11.0 2.7 24.3 1.1 2.8 0.3 1.2 12.1 7.0 16.1 15.8 20.4 23.1 5.1 2.1 3.2 9.6 8.0 5.3 0.5 32.7 5.1 10.0 3.9 28.9 0.4 18.7 36.2 7.1 3.5 7.4 23.5 10.1 42.7 19.2 0.2 13.7 7.2 1.0 34.1 17.0 2.8 1.2 0.4 13.5 0.3 31.3 0.5 0.1 0.6 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.3 0.0 0.1 0.7 0.0 0.1 0.4 0.0 0.1 6.9 7.7 17.2 5.0 7.0 4.9 3.6 10.4 4.9 2.1 8.2 4.4 16.5 35.3 20.7 129.3 0.7 21.4 31.5 24.7 82.6 10.7 8.5 13.2 4.8 8.6 19.6 23.9 18.8 9.1 1.3 22.6 1.9 13.4 2.2 39.8 8.9 25.4 12.1 2.7 15.5 8.7 26.9 16.2 10.7 38.5 1.3 13.4 69.9 4.0 1.5 69.0 44.3 9.0 2.0 2.5 5.8 7.9 30.1 1.2 3.6 23.4 0.0 37.0 0.0 66.4 59.2 7.3 17.2 41.3 0.2 8.2 11.3 1.5 19.3 2.9 6.6 3.7 3.3 0.3 2.4 36.1 10.1 20.0 0.8 9.7 20.0 49.2 MID2 "FXY2, MRX101, RNF60, TRIM1" ENSG00000080561 "Midline 2" Q9UJV3 X 107825755-107931637 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 14.5;Inhibitory neurons: 21.5;Urothelial cells: 11.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Lineage enriched" "Detected in single" 6 "T-cells: 1.6" "Cell line enhanced" "Detected in many" "HUVEC TERT2: 41.5;Karpas-707: 35.5;MCF7: 26.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 2: Karpas-707 - Immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "unprognostic (8.28e-2)" "unprognostic (8.51e-2)" "unprognostic (3.69e-4)" "unprognostic (6.40e-3)" "unprognostic (1.16e-1)" "unprognostic (7.50e-2)" "unprognostic (3.87e-1)" "unprognostic (7.20e-2)" "unprognostic (1.09e-2)" "unprognostic (4.87e-2)" "unprognostic (2.00e-1)" "unprognostic (2.09e-1)" "unprognostic (3.19e-2)" "prognostic unfavorable (3.73e-4)" "unprognostic (2.07e-1)" "unprognostic (3.77e-1)" "unprognostic (5.97e-3)" 11.2 9.2 5.2 3.9 6.1 0.4 7.2 4.4 4.2 8.3 4.2 6.0 1.8 9.4 8.0 13.6 8.8 7.7 3.1 3.5 12.1 6.0 5.4 6.4 4.4 7.4 7.1 9.3 9.6 12.9 3.2 4.4 9.1 10.3 3.6 14.8 11.1 9.6 12.9 9.6 2.6 15.8 6.3 3.8 4.4 2.1 9.0 2.3 13.2 18.5 5.2 10.6 7.5 4.8 8.4 7.1 0.2 11.2 8.8 12.3 0.1 5.9 15.0 5.0 3.6 0.6 1.5 0.0 7.5 11.7 8.3 5.2 4.1 12.1 1.1 0.0 5.5 0.0 4.2 0.0 13.5 0.0 0.0 8.0 13.3 0.1 14.5 9.1 41.5 0.5 0.0 35.5 5.6 26.8 0.1 0.0 1.2 0.3 13.0 0.0 3.2 0.0 6.3 7.5 0.6 0.0 12.6 0.5 18.6 3.9 4.6 0.5 8.2 0.0 2.1 9.9 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 1.3 0.0 0.8 1.4 0.0 0.2 1.6 1.1 0.0 0.0 0.0 0.0 0.1 0.4 5.2 6.1 4.4 4.2 3.5 12.1 7.4 7.1 9.1 6.3 9.0 4.8 3.1 3.2 0.0 8.1 0.4 3.1 3.3 0.9 4.0 1.9 2.3 1.8 0.6 1.5 1.1 0.0 0.0 0.0 0.3 0.3 1.9 1.8 1.1 1.0 1.7 2.6 0.0 0.0 14.5 1.5 0.0 1.5 1.1 1.5 0.0 0.3 2.2 1.8 0.1 0.0 21.5 0.2 0.0 0.0 0.0 1.4 0.0 0.2 3.6 7.5 0.0 0.8 0.0 8.0 7.4 1.1 0.0 0.7 1.1 4.2 0.5 0.8 2.3 3.9 0.0 1.9 2.1 0.2 0.4 3.9 3.7 0.0 1.7 0.8 0.4 11.4 MINK1 "B55, MAP4K6, MINK, YSK2, ZC3" ENSG00000141503 "Misshapen like kinase 1" Q8N4C8 17 4833340-4898061 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA056296 Approved NA NA 26000 "Cluster 52: Eosinophils - Transcription" "Cluster 31: Skin - Epidermis development" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 61: Squamous epithelial cells - Keratinization" "HPA056296: AB_2683090" "unprognostic (2.80e-1)" "unprognostic (3.83e-2)" "unprognostic (1.85e-1)" "unprognostic (6.62e-2)" "unprognostic (2.88e-1)" "unprognostic (3.26e-3)" "prognostic unfavorable (3.00e-4)" "unprognostic (4.64e-3)" "unprognostic (3.21e-1)" "unprognostic (2.78e-2)" "prognostic favorable (2.77e-4)" "prognostic unfavorable (9.27e-4)" "unprognostic (8.44e-3)" "unprognostic (2.49e-2)" "unprognostic (1.37e-1)" "unprognostic (2.47e-2)" "unprognostic (1.62e-1)" 22.8 21.5 32.4 24.9 29.8 22.7 24.7 13.0 34.4 32.0 0.0 36.9 43.0 19.1 5.7 72.1 21.3 18.6 15.4 50.7 15.1 23.0 17.5 35.6 23.9 17.7 16.2 36.9 29.4 23.2 25.7 23.2 15.3 25.5 28.1 18.2 32.4 12.2 12.5 76.9 41.7 14.6 13.4 27.6 29.0 14.2 26.4 16.8 21.9 9.9 18.8 21.8 46.6 20.2 46.9 83.6 20.2 31.2 29.7 21.8 56.0 37.4 34.2 27.6 24.7 32.3 31.3 34.5 41.5 38.2 30.0 91.8 15.5 64.2 20.2 49.0 41.2 23.9 62.8 25.3 18.8 9.1 45.2 22.4 44.1 27.1 25.2 24.9 30.8 10.8 25.6 27.4 22.9 27.8 14.8 20.2 15.6 30.4 28.4 17.9 16.9 20.4 42.2 53.9 20.9 16.6 40.1 30.7 23.9 24.2 27.7 12.2 45.0 29.6 13.7 52.8 35.6 16.8 14.6 7.3 26.7 19.2 20.5 0.0 0.7 2.9 1.0 0.6 1.2 1.1 1.1 0.8 0.5 0.7 0.7 0.3 0.6 0.1 0.3 0.3 1.3 1.2 32.4 29.8 13.0 34.4 50.7 15.1 17.7 16.2 15.3 13.4 26.4 20.2 18.1 0.0 2.0 51.9 12.7 41.0 14.7 22.0 37.5 7.2 17.3 18.8 1.4 22.8 9.9 5.5 39.6 18.9 10.2 47.3 5.9 9.5 3.6 10.6 8.6 15.4 18.7 13.0 25.5 10.5 13.3 8.5 51.0 12.7 8.2 21.1 16.1 9.8 18.3 13.5 24.7 30.3 16.2 12.3 16.7 6.8 16.1 13.9 16.0 37.5 29.5 6.9 9.2 13.0 48.1 14.8 46.7 14.7 9.7 19.9 29.3 13.0 12.8 16.9 13.1 6.9 7.6 5.8 13.8 40.9 60.5 19.6 15.9 28.3 27.4 20.1 MKNK1 MNK1 ENSG00000079277 "MAPK interacting serine/threonine kinase 1" Q9BUB5 1 46557407-46616843 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Translation regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "pancreas: 128.6" "Cell type enhanced" "Detected in all" "Hofbauer cells: 142.8;Microglial cells: 100.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB027355, CAB037310, HPA071293" Approved Supported Nucleoplasm NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 25: Pancreas - Digestion" "Cluster 36: HEL - Hemostasis" "Cluster 4: Macrophages - Innate immune response" Nucleoplasm "CAB027355: AB_2266303, CAB037310: AB_1854049, HPA071293: AB_2686382" "unprognostic (4.05e-3)" "prognostic favorable (7.05e-4)" "unprognostic (5.28e-2)" "unprognostic (3.47e-2)" "unprognostic (1.64e-1)" "unprognostic (7.38e-2)" "prognostic unfavorable (1.24e-5)" "unprognostic (3.50e-2)" "unprognostic (1.77e-1)" "unprognostic (2.60e-1)" "unprognostic (1.50e-1)" "unprognostic (2.14e-2)" "prognostic unfavorable (1.51e-5)" "unprognostic (7.02e-2)" "unprognostic (3.19e-2)" "unprognostic (4.67e-1)" "unprognostic (5.67e-3)" 30.6 21.8 15.5 23.5 14.4 30.3 23.1 19.0 18.0 22.8 17.0 27.4 15.6 18.5 12.0 23.5 21.4 16.1 22.3 15.1 14.6 17.5 21.8 31.5 17.0 14.2 13.3 19.0 128.6 12.0 18.4 22.1 14.4 19.4 17.7 3.9 16.7 8.5 23.9 18.0 24.9 18.4 13.7 48.1 23.1 12.4 16.6 22.6 16.2 23.9 13.8 20.1 20.7 16.5 34.1 21.7 13.5 15.7 12.0 17.9 18.0 16.7 16.4 20.7 27.1 26.4 13.5 23.1 20.2 17.8 23.0 38.5 23.8 27.5 23.1 37.7 21.4 47.8 28.3 21.7 17.3 25.4 34.8 22.0 17.7 25.2 13.4 10.8 24.1 26.2 24.7 16.6 12.2 21.5 18.3 21.8 9.9 19.6 24.8 16.7 30.5 22.1 20.2 35.2 10.4 9.0 32.3 27.9 25.6 26.5 21.5 28.6 18.5 7.6 1.4 22.2 19.9 12.6 23.7 21.2 14.6 31.9 13.4 9.7 26.3 36.1 15.3 25.7 44.7 9.9 12.9 14.2 13.1 11.6 9.2 13.9 69.7 11.2 20.6 9.7 10.6 14.5 15.5 14.4 19.0 18.0 15.1 14.6 14.2 13.3 14.4 13.7 16.6 16.5 20.3 12.8 21.5 41.4 15.3 13.9 17.8 15.2 9.1 19.4 17.8 12.3 19.2 15.7 17.8 22.0 2.1 21.6 23.7 27.9 7.9 18.9 15.5 12.5 12.8 18.3 16.8 21.9 42.2 37.1 34.2 20.5 11.7 13.3 12.0 22.8 18.2 22.7 142.8 18.5 52.7 12.0 4.1 84.5 61.0 23.8 21.5 49.9 10.6 100.2 26.7 5.2 21.6 21.6 8.5 32.3 17.7 36.5 13.3 19.5 27.8 15.7 11.1 5.0 6.6 31.2 15.0 15.3 17.2 22.6 11.1 18.5 25.2 35.1 15.0 29.6 MKNK2 "GPRK7, MNK2" ENSG00000099875 "MAPK interacting serine/threonine kinase 2" Q9HBH9 19 2037465-2051244 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Translation regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 475.7;tongue: 551.1" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HHSteC: 367.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021875, CAB037253, HPA070499" Supported Supported "Nuclear bodies" No No "Cluster 33: Neutrophils - Chromatin organization" "Cluster 80: Striated muscle - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 7: Non-specific - Mitochondria" "Nuclear bodies" "CAB037253: AB_1079401, HPA021875: AB_1854050, HPA070499: AB_2732157" "unprognostic (8.76e-2)" "unprognostic (1.71e-1)" "unprognostic (1.64e-1)" "prognostic favorable (4.86e-5)" "unprognostic (3.08e-1)" "unprognostic (1.59e-2)" "unprognostic (6.42e-3)" "unprognostic (1.35e-1)" "unprognostic (4.32e-2)" "unprognostic (7.52e-2)" "unprognostic (1.08e-1)" "unprognostic (6.56e-2)" "unprognostic (4.07e-2)" "prognostic favorable (4.01e-4)" "unprognostic (1.63e-1)" "unprognostic (1.60e-1)" "unprognostic (1.59e-1)" 87.2 50.2 70.5 51.3 78.0 133.6 39.5 109.2 131.2 41.9 80.6 55.2 47.4 24.7 47.8 114.5 38.1 26.7 54.8 67.2 65.4 27.6 71.2 51.8 66.8 80.3 70.7 34.5 191.9 34.5 39.6 35.3 74.6 38.6 30.0 35.7 133.8 39.7 475.7 63.8 57.3 21.8 68.2 80.2 55.1 21.6 75.7 34.5 54.6 551.1 58.6 39.9 60.9 91.0 64.9 71.8 30.1 66.3 219.5 79.0 65.1 37.3 27.1 26.5 26.8 45.5 111.8 88.2 50.7 77.4 27.9 78.4 38.4 110.9 12.0 122.1 34.4 36.8 62.1 49.2 367.4 72.3 61.6 84.1 262.0 50.8 107.2 61.9 63.5 59.2 62.0 155.4 18.6 37.7 42.8 59.3 78.6 49.6 78.1 81.8 8.6 113.1 48.1 41.2 39.9 48.2 89.0 125.1 166.4 33.5 52.7 89.5 96.5 9.5 37.5 38.5 46.0 238.9 97.0 85.7 78.2 53.5 17.9 4.4 9.2 9.8 8.1 10.2 7.5 16.9 8.4 9.4 7.7 15.0 5.4 6.6 41.7 9.5 13.6 9.2 12.5 3.6 70.5 78.0 109.2 131.2 67.2 65.4 80.3 70.7 74.6 68.2 75.7 91.0 102.2 38.5 56.5 9.8 91.4 82.5 105.6 84.5 50.1 55.7 99.0 103.5 54.5 38.6 65.5 36.8 25.0 23.5 106.5 155.3 9.8 27.3 8.7 60.2 28.0 51.9 150.2 80.2 5.6 56.6 47.2 45.0 57.6 76.2 29.2 14.5 82.5 60.3 36.9 42.1 5.9 104.1 46.8 52.5 134.6 13.0 20.2 68.0 56.9 8.4 41.8 63.6 30.9 6.0 5.2 47.2 86.6 20.3 55.4 94.2 98.8 18.6 55.2 47.5 19.7 132.6 48.7 18.1 19.5 97.8 117.2 56.5 69.3 18.1 79.7 114.0 MKRN1 RNF61 ENSG00000133606 "Makorin ring finger protein 1" Q9UHC7 7 140453033-140479536 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 328.0;Erythroid cells: 424.2;Late spermatids: 340.6" "Cancer enriched" "Detected in all" 5 "testis cancer: 129.7" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000567 Approved Nucleoplasm,Cytosol NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 29: U-266 - Adaptive immune response" "Cluster 6: Erythroid cells - Oxygen transport" "Nucleoplasm, Cytosol" "HPA000567: AB_1079299" "unprognostic (9.97e-2)" "unprognostic (1.50e-1)" "unprognostic (1.27e-1)" "unprognostic (7.60e-3)" "unprognostic (1.65e-2)" "unprognostic (2.41e-1)" "unprognostic (4.87e-3)" "unprognostic (1.24e-2)" "unprognostic (8.02e-2)" "unprognostic (2.97e-2)" "unprognostic (2.52e-1)" "unprognostic (1.35e-1)" "unprognostic (2.89e-3)" "unprognostic (5.76e-2)" "unprognostic (2.42e-1)" "unprognostic (1.22e-1)" "unprognostic (1.22e-2)" 39.5 36.8 50.9 47.9 50.7 202.6 47.8 52.6 57.1 43.0 46.6 97.9 69.2 46.7 43.3 49.0 51.3 37.5 64.6 51.0 53.7 47.9 42.7 46.9 49.7 57.6 50.7 56.5 58.1 66.8 42.3 43.0 58.9 48.6 80.1 58.6 56.5 44.4 84.0 51.7 65.8 43.5 50.2 52.7 53.9 123.2 55.6 47.1 46.9 58.5 56.4 45.7 38.9 50.9 96.5 72.3 55.6 83.1 86.5 75.5 78.2 64.6 83.3 49.8 57.2 30.0 98.8 69.4 98.4 63.4 99.2 45.7 63.2 71.2 62.8 138.0 55.6 72.1 43.5 55.9 69.4 62.5 107.1 75.4 105.1 56.2 52.8 81.9 50.8 46.9 58.0 84.8 49.1 82.6 73.4 114.2 143.3 80.7 53.6 52.4 47.4 107.6 80.8 109.2 76.6 79.1 80.8 108.5 120.6 81.6 53.3 53.5 71.9 34.9 27.4 85.8 59.8 200.2 159.2 60.9 99.3 96.1 73.3 58.6 22.5 100.4 15.4 21.3 18.0 33.6 29.5 23.0 18.0 32.9 39.9 25.5 42.5 31.1 26.5 6.0 35.3 15.3 50.9 50.7 52.6 57.1 51.0 53.7 57.6 50.7 58.9 50.2 55.6 50.9 28.4 51.3 37.2 13.4 76.8 82.1 66.6 57.1 57.5 61.5 60.9 36.2 57.7 67.2 71.1 42.3 35.5 75.8 54.0 172.1 103.7 69.8 328.0 58.4 30.6 34.2 97.3 424.2 28.9 67.8 96.6 43.3 38.7 65.7 37.4 79.5 45.7 45.0 59.5 119.5 28.0 107.7 89.5 95.9 93.3 340.6 66.5 86.3 69.4 22.5 119.0 61.4 92.7 15.1 22.1 57.6 140.3 62.4 41.8 101.2 112.4 54.4 70.0 46.4 46.0 34.7 53.3 303.0 60.1 62.4 95.5 138.0 62.9 39.6 103.5 145.9 MKRN2 "HSPC070, RNF62" ENSG00000075975 "Makorin ring finger protein 2" Q9H000 3 12557057-12586208 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 10 "Early spermatids: 572.9;Late spermatids: 774.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037559, HPA037560" Enhanced Approved Nucleoplasm,Cytosol NA NA "Cluster 44: Non-specific - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 28: BEWO - Transcription regulation" "Cluster 34: Spermatids - Unknown function" "Nucleoplasm, Cytosol" "HPA037559: AB_10672460, HPA037560: AB_10696936" "unprognostic (4.17e-2)" "unprognostic (1.08e-1)" "unprognostic (1.59e-2)" "unprognostic (5.99e-2)" "unprognostic (3.89e-2)" "unprognostic (1.47e-2)" "prognostic unfavorable (1.58e-4)" "unprognostic (4.38e-1)" "unprognostic (8.49e-2)" "unprognostic (2.86e-1)" "unprognostic (1.42e-1)" "unprognostic (2.56e-3)" "prognostic favorable (6.04e-4)" "unprognostic (3.26e-1)" "unprognostic (2.22e-1)" "unprognostic (1.33e-2)" "unprognostic (3.32e-2)" 16.3 11.5 15.1 10.9 15.1 3.5 13.8 16.9 17.6 15.7 13.5 16.3 13.0 16.6 12.0 17.9 14.7 11.6 32.5 15.1 17.0 16.0 15.1 13.4 14.5 15.5 15.9 21.7 24.1 23.9 12.8 16.7 16.1 12.5 13.5 11.4 14.0 14.0 32.0 14.5 12.2 18.9 16.7 10.7 13.7 56.3 16.7 21.4 21.1 24.5 17.3 15.3 14.3 17.6 20.6 18.8 24.5 17.4 45.2 44.3 40.6 30.0 35.5 41.7 34.1 19.2 18.8 26.7 16.9 37.7 18.8 10.9 38.4 33.1 37.1 30.9 29.2 40.3 19.1 31.1 51.9 38.8 14.4 46.8 30.6 47.6 30.2 34.8 34.9 39.1 39.7 30.8 37.7 25.9 51.4 17.8 16.5 21.7 40.4 45.9 26.0 32.2 30.4 24.8 14.8 26.4 28.4 12.8 30.4 17.3 29.7 38.0 31.1 23.0 23.0 28.5 43.0 26.6 62.8 60.8 28.8 49.5 41.1 20.9 17.9 32.9 20.7 16.4 26.4 21.3 21.4 22.0 19.8 16.5 22.8 20.8 13.2 27.8 23.3 15.9 24.5 20.2 15.1 15.1 16.9 17.6 15.1 17.0 15.5 15.9 16.1 16.7 16.7 17.6 15.4 19.2 9.6 9.8 13.8 9.6 9.9 13.5 10.2 13.8 8.5 8.9 14.7 1.5 14.2 5.5 4.2 19.7 20.8 7.6 19.6 16.1 572.9 9.7 13.8 14.1 2.4 5.0 15.9 16.8 19.6 11.4 5.1 10.1 19.0 17.3 7.9 5.8 15.5 11.8 15.5 10.0 6.1 7.2 9.1 774.2 20.5 9.6 16.0 6.5 20.1 19.1 20.6 14.1 11.1 16.0 10.8 20.7 14.7 9.5 12.0 11.6 14.2 13.2 13.1 11.3 17.4 66.5 38.4 8.1 9.2 16.1 15.7 23.6 10.1 9.8 MKRN3 "D15S9, MGC88288, RNF63, ZFP127, ZNF127" ENSG00000179455 "Makorin ring finger protein 3" Q13064 15 23565674-23630075 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 14.1;retina: 8.9" "Cell type enhanced" "Detected in some" "Bipolar cells: 13.8;Cone photoreceptor cells: 25.0;Horizontal cells: 6.7;Oligodendrocyte precursor cells: 6.0;Oligodendrocytes: 9.0;Rod photoreceptor cells: 7.4" "Cancer enhanced" "Detected in some" "glioma: 1.5" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "naive CD8 T-cell: 2.3" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "JURKAT: 26.3;K-562: 30.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA029494 Uncertain Approved "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 1: K-562 - Erythropoiesis" "Cluster 9: Photoreceptor cells - Phototransduction" "Plasma membrane, Cytosol" Nucleoplasm "HPA029494: AB_10603873" "unprognostic (3.18e-1)" "unprognostic (1.26e-1)" "unprognostic (4.26e-1)" "unprognostic (1.86e-3)" "unprognostic (1.04e-3)" "unprognostic (1.15e-2)" "unprognostic (6.27e-4)" "unprognostic (1.51e-1)" "unprognostic (8.52e-2)" "unprognostic (7.05e-2)" "unprognostic (4.97e-3)" "unprognostic (2.86e-1)" "unprognostic (1.05e-4)" "unprognostic (5.37e-2)" "unprognostic (1.52e-1)" "unprognostic (8.91e-2)" "unprognostic (9.78e-2)" 0.3 0.1 4.5 0.4 7.7 1.8 0.5 4.8 6.7 0.1 2.4 0.5 0.2 0.4 1.6 3.4 3.1 0.1 0.1 5.2 5.1 0.3 0.1 0.2 0.7 7.0 6.1 0.2 0.4 0.0 1.1 3.3 7.0 0.3 0.1 8.9 3.1 0.2 0.8 0.4 0.3 0.1 4.0 0.6 0.2 2.4 6.6 2.4 0.2 0.8 0.8 0.2 0.2 14.1 8.5 2.9 6.1 5.6 0.0 0.0 13.0 0.9 0.0 4.3 4.5 14.7 0.0 0.1 0.1 0.0 11.8 12.5 2.4 0.0 2.7 0.1 0.5 15.3 17.0 0.9 0.4 18.6 10.2 0.6 0.0 5.8 0.0 2.8 0.0 26.3 30.6 12.9 3.5 0.0 20.3 7.3 0.0 9.6 12.1 10.7 2.5 7.5 0.0 0.1 1.6 4.4 0.0 7.7 0.1 0.2 4.2 5.2 0.1 13.5 9.9 0.9 9.6 16.8 24.5 8.6 7.9 0.1 0.1 0.6 0.2 0.1 0.6 0.0 0.3 0.2 0.2 0.4 0.0 0.2 0.6 2.3 0.4 0.1 0.1 0.3 0.1 0.3 4.5 7.7 4.8 6.7 5.2 5.1 7.0 6.1 7.0 4.0 6.6 14.1 0.0 0.0 0.0 0.7 0.1 0.5 1.2 0.0 0.0 13.8 0.3 0.0 0.7 0.0 0.1 0.0 25.0 0.8 0.0 0.0 0.0 0.0 0.8 0.1 0.2 0.2 0.0 0.0 0.0 0.0 0.3 0.4 0.0 0.0 0.0 0.4 0.0 0.0 0.0 6.7 0.4 0.0 0.0 0.0 0.6 0.5 0.0 0.1 1.8 1.0 0.1 3.4 0.0 6.0 9.0 0.0 0.0 0.4 0.0 0.5 0.0 0.0 0.2 7.4 0.0 0.7 1.6 2.6 0.9 1.8 0.0 0.5 0.2 0.1 0.0 0.4 MMAB "cblB, CFAP23" ENSG00000139428 "Metabolism of cobalamin associated B" Q96EY8 12 109553715-109573580 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 103.6" "Cell type enhanced" "Detected in all" "Hepatocytes: 225.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039017 Supported Approved Mitochondria NA NA "Cluster 44: Non-specific - Transcription" "Cluster 18: Non-specific - Mitochondria" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 15: Hepatocytes - Hemostasis" Mitochondria "HPA039017: AB_10673603" "unprognostic (1.16e-1)" "unprognostic (1.25e-2)" "unprognostic (1.90e-1)" "unprognostic (1.79e-1)" "unprognostic (4.38e-2)" "unprognostic (2.10e-1)" "unprognostic (1.38e-1)" "unprognostic (4.22e-1)" "unprognostic (2.04e-2)" "unprognostic (5.15e-2)" "unprognostic (1.47e-3)" "unprognostic (2.58e-1)" "prognostic favorable (1.55e-4)" "unprognostic (4.90e-2)" "unprognostic (1.51e-1)" "unprognostic (2.23e-1)" "unprognostic (9.65e-2)" 15.5 51.2 17.8 6.3 18.3 5.8 15.8 18.8 26.9 12.4 18.6 15.8 13.0 10.7 21.2 29.1 13.0 6.0 30.0 17.0 18.8 32.8 103.6 14.9 6.2 22.2 19.0 18.9 23.0 9.8 20.5 4.9 21.3 26.5 7.9 7.3 17.1 6.3 21.1 18.2 14.0 5.6 19.0 12.4 17.7 12.6 18.9 5.5 22.1 16.2 6.5 14.1 14.7 22.9 32.2 22.3 22.2 17.6 8.8 17.7 11.3 7.1 16.2 10.3 10.8 25.8 29.5 21.0 19.9 8.0 19.1 32.9 14.6 54.9 4.6 8.2 60.9 8.6 15.9 42.1 31.3 18.4 7.2 24.0 33.5 22.2 9.7 12.3 9.7 16.4 27.5 15.5 7.3 74.7 16.6 29.2 27.3 3.3 31.6 13.6 8.7 53.9 45.3 30.3 34.1 14.8 15.8 29.2 12.7 6.2 60.5 50.5 5.4 8.6 3.6 6.1 10.4 11.9 9.6 24.0 19.0 22.2 23.9 7.4 7.2 1.0 15.3 10.0 12.2 13.6 11.1 12.1 11.3 17.8 15.2 14.6 1.9 11.2 10.9 9.2 5.8 10.3 17.8 18.3 18.8 26.9 17.0 18.8 22.2 19.0 21.3 19.0 18.9 22.9 25.1 35.3 80.8 9.8 20.4 10.3 33.1 105.6 17.1 32.9 59.6 47.0 52.3 60.1 68.9 42.3 29.2 55.4 15.2 33.6 150.6 49.7 41.3 23.8 10.0 22.1 33.0 34.1 6.4 71.3 37.6 24.7 28.5 16.5 16.5 34.3 28.5 225.3 34.8 104.3 8.5 50.4 71.2 20.4 10.2 82.9 40.4 13.5 26.6 4.7 25.1 30.6 30.9 6.6 21.5 29.7 30.0 30.5 18.1 31.8 61.9 143.6 62.1 29.7 13.1 17.9 26.3 26.0 15.8 44.7 19.7 61.8 16.1 121.1 56.6 30.3 MMACHC "cblC, DKFZP564I122" ENSG00000132763 "Metabolism of cobalamin associated C" Q9Y4U1 1 45500300-45513382 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Oxidoreductase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 17.4" "Cell type enhanced" "Detected in many" "Hepatocytes: 22.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027394, HPA027399, HPA027402" Uncertain Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 59: Non-specific - Transcription" Nucleoplasm "Plasma membrane, Cytosol" "HPA027394: AB_10601669, HPA027399: AB_10601987, HPA027402: AB_2672255" "unprognostic (3.34e-1)" "unprognostic (1.63e-1)" "unprognostic (7.03e-3)" "unprognostic (3.14e-2)" "unprognostic (4.05e-1)" "unprognostic (1.16e-2)" "unprognostic (9.04e-2)" "unprognostic (1.03e-2)" "unprognostic (1.90e-1)" "unprognostic (1.05e-2)" "unprognostic (3.88e-2)" "unprognostic (6.81e-2)" "unprognostic (2.61e-3)" "unprognostic (2.08e-3)" "unprognostic (8.83e-2)" "unprognostic (2.50e-2)" "unprognostic (2.58e-2)" 2.0 3.1 3.3 1.7 5.3 1.2 3.5 5.1 4.2 2.9 2.3 3.7 3.3 1.7 3.0 2.8 3.5 1.3 6.9 3.4 5.1 3.5 17.4 1.2 1.8 4.1 5.6 3.5 2.9 5.5 1.3 1.5 3.9 2.0 4.4 2.1 5.0 2.4 10.8 2.0 2.4 2.3 3.5 1.6 2.3 4.3 5.6 2.2 2.3 6.6 2.0 1.7 1.5 6.0 7.7 3.9 6.6 10.0 6.1 3.7 8.1 5.9 3.9 10.5 9.4 8.3 4.7 12.0 7.4 4.9 2.0 6.2 12.3 14.0 9.6 3.3 11.4 9.4 6.5 9.2 5.8 13.5 3.3 5.3 7.8 11.6 12.6 3.7 5.1 12.5 10.8 6.7 8.1 8.2 9.1 4.3 10.9 8.8 8.9 11.1 2.7 13.2 6.2 6.0 10.5 5.4 8.8 14.5 19.3 4.9 8.3 4.6 2.3 7.3 9.9 8.3 3.3 9.9 8.5 6.9 5.3 6.4 6.9 2.3 0.5 0.5 0.5 0.8 0.8 0.7 0.7 0.4 0.6 0.6 1.3 0.6 0.9 0.8 2.7 1.3 0.4 0.4 3.3 5.3 5.1 4.2 3.4 5.1 4.1 5.6 3.9 3.5 5.6 6.0 1.1 3.2 5.5 1.6 2.1 0.1 1.8 0.8 5.7 1.3 2.7 1.5 9.8 4.3 2.2 1.8 0.0 3.7 0.6 2.8 5.9 1.3 1.0 3.6 4.8 1.5 4.2 4.8 2.6 1.4 4.3 3.6 7.1 3.2 2.5 2.9 2.5 22.9 3.3 3.3 2.7 3.2 2.0 3.2 0.9 1.2 1.8 2.7 0.0 0.0 0.6 1.4 3.1 1.5 5.3 1.8 2.3 1.5 10.4 1.7 2.0 4.6 1.2 5.2 0.0 5.0 2.4 7.4 2.1 11.5 0.1 2.7 2.4 3.9 5.8 1.8 MOCOS "FLJ20733, HMCS, MOS" ENSG00000075643 "Molybdenum cofactor sulfurase" Q96EN8 18 36187497-36272157 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Molybdenum cofactor biosynthesis" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adrenal gland: 10.3;liver: 16.0" "Cell type enhanced" "Detected in many" "Glandular and luminal cells: 18.8;Hepatocytes: 39.4;Proximal enterocytes: 22.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "hTCEpi: 40.7;hTERT-HME1: 49.7;SiHa: 54.9;SK-MEL-30: 38.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA039412, HPA047958" Uncertain Supported Mitochondria,Cytosol NA NA "Cluster 17: Basophils - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 30: Epithelial cell lines - Translation" "Cluster 2: Hepatocytes - Metabolism" Mitochondria Cytosol "HPA039412: AB_2676496, HPA047958: AB_2680225" "unprognostic (3.07e-3)" "unprognostic (1.81e-1)" "unprognostic (1.69e-2)" "unprognostic (1.50e-1)" "unprognostic (3.18e-3)" "unprognostic (2.55e-1)" "unprognostic (1.97e-1)" "prognostic unfavorable (3.55e-4)" "unprognostic (5.84e-2)" "unprognostic (1.33e-1)" "prognostic unfavorable (1.29e-4)" "unprognostic (2.91e-2)" "prognostic unfavorable (3.03e-12)" "unprognostic (8.98e-2)" "unprognostic (2.37e-1)" "unprognostic (4.09e-1)" "unprognostic (6.35e-2)" 2.0 10.3 0.3 0.9 0.3 0.3 2.5 0.5 0.5 0.9 0.5 1.6 6.1 0.8 1.9 3.8 1.7 1.4 0.3 0.4 0.4 1.2 16.0 1.6 0.2 1.2 0.3 6.4 0.8 2.3 2.0 1.0 1.3 1.3 1.6 0.7 1.8 3.3 0.6 2.0 6.4 0.6 0.2 0.3 1.6 0.9 0.6 0.1 1.2 0.4 1.2 2.7 0.7 0.3 14.3 4.8 0.2 0.1 4.3 5.5 2.9 8.2 4.6 3.9 10.0 3.1 4.4 0.1 2.5 13.4 1.0 8.6 2.9 12.9 5.4 2.4 2.3 0.2 13.5 11.8 14.6 0.1 3.8 8.7 40.7 15.2 49.7 0.5 0.6 0.1 4.9 0.1 6.2 3.6 0.0 0.1 0.8 3.4 4.1 0.0 0.1 0.0 5.5 18.5 0.1 1.2 54.9 3.3 38.8 0.9 2.5 0.2 2.7 3.0 3.7 6.7 1.4 0.1 0.1 0.1 7.8 0.1 1.3 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.3 0.3 0.5 0.5 0.4 0.4 1.2 0.3 1.3 0.2 0.6 0.3 0.9 12.8 5.0 0.3 0.9 0.6 1.4 3.7 1.8 0.3 4.5 1.9 1.0 4.3 6.4 0.0 2.1 0.5 0.2 2.2 0.0 3.1 7.2 5.9 3.4 0.8 3.0 0.0 0.9 12.4 4.3 2.4 1.5 18.8 0.0 2.0 0.4 39.4 0.6 0.0 1.1 3.1 6.1 0.6 2.6 3.2 1.8 1.0 3.6 4.7 11.9 6.6 0.0 1.0 0.3 4.6 2.3 9.1 0.9 2.3 22.4 0.2 4.5 0.5 0.0 6.5 1.2 0.1 0.3 5.1 1.3 2.3 0.5 2.7 4.5 2.2 MOCS2 "MOCO1, MOCS2A, MOCS2B" ENSG00000164172 "Molybdenum cofactor synthesis 2" "O96007, O96033" 5 53095679-53110063 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Molybdenum cofactor biosynthesis" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal tubular cells: 573.2;Proximal tubular cells: 281.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037679, HPA037680" Approved Supported "Nucleoplasm,Nuclear speckles,Cytosol" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 39: Non-specific - Basic cellular processes" Cytosol "Nucleoplasm, Nuclear speckles" "HPA037679: AB_2675604, HPA037680: AB_10673635" "unprognostic (3.27e-1)" "unprognostic (3.11e-2)" "unprognostic (2.82e-1)" "unprognostic (8.37e-3)" "unprognostic (2.12e-1)" "unprognostic (3.48e-2)" "unprognostic (1.60e-2)" "unprognostic (1.33e-1)" "unprognostic (6.66e-2)" "unprognostic (7.59e-2)" "unprognostic (2.41e-3)" "unprognostic (1.85e-1)" "prognostic favorable (3.68e-6)" "unprognostic (1.04e-1)" "unprognostic (1.04e-2)" "unprognostic (2.04e-1)" "unprognostic (5.86e-2)" 48.7 79.4 79.1 24.9 84.9 9.1 42.1 80.3 107.6 34.7 74.4 41.9 40.8 30.0 45.9 35.2 26.5 31.3 87.0 84.3 86.3 114.8 126.2 28.2 26.1 79.2 80.5 43.5 42.4 89.6 30.5 35.9 82.4 36.8 32.3 59.3 48.9 44.9 109.3 16.6 40.2 34.4 85.6 23.6 37.2 26.0 88.0 28.3 55.4 111.8 25.2 30.8 24.6 87.4 79.4 62.7 42.9 109.9 85.0 83.2 51.6 99.5 91.9 74.4 89.8 79.7 56.5 76.7 143.5 69.9 127.1 45.0 91.7 96.7 117.2 19.6 84.8 61.7 58.2 75.9 94.4 65.0 43.0 65.1 41.7 91.7 83.5 81.0 85.1 101.4 58.7 44.2 129.5 115.5 72.7 31.8 37.0 34.2 130.1 36.0 93.0 67.0 144.1 56.6 29.4 33.7 69.4 57.3 72.9 56.9 107.2 15.4 55.6 76.9 81.0 69.1 120.5 49.4 84.8 91.5 106.7 16.8 125.1 14.5 21.8 15.6 36.9 26.9 46.2 37.5 42.7 42.8 29.8 40.5 55.3 49.2 3.8 43.5 25.4 27.8 44.9 28.9 79.1 84.9 80.3 107.6 84.3 86.3 79.2 80.5 82.4 85.6 88.0 87.4 51.7 54.5 29.7 14.4 23.5 13.4 40.1 48.5 19.9 30.2 55.7 50.5 122.9 62.9 37.9 69.9 27.1 95.4 19.4 18.2 573.2 43.7 7.3 22.6 29.0 37.6 26.4 18.7 19.1 43.7 37.3 55.7 19.9 26.8 10.1 38.8 26.0 132.6 41.3 6.7 18.4 22.7 44.7 31.2 20.1 14.6 50.7 28.7 23.2 6.5 12.2 67.5 29.9 4.5 11.9 22.1 18.2 68.8 26.7 34.5 65.7 281.7 32.9 21.7 32.9 73.8 49.4 46.7 62.9 37.5 15.6 32.3 25.8 64.2 30.9 34.5 MOCS3 "dJ914P20.3, UBA4" ENSG00000124217 "Molybdenum cofactor synthesis 3" O95396 20 50958818-50963929 "Enzymes, Predicted intracellular proteins" "Molybdenum cofactor biosynthesis, tRNA processing" "Multifunctional enzyme, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 90.9;Late spermatids: 26.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027556 Uncertain NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 23: Testis - Cell cycle regulation" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 29: Early spermatids - Spermatogenesis" "HPA027556: AB_2672333" "unprognostic (1.29e-1)" "unprognostic (2.57e-1)" "unprognostic (3.16e-1)" "prognostic unfavorable (5.82e-4)" "unprognostic (2.11e-1)" "unprognostic (1.17e-1)" "prognostic unfavorable (1.39e-4)" "unprognostic (3.76e-1)" "unprognostic (3.19e-1)" "unprognostic (1.33e-2)" "unprognostic (8.67e-3)" "unprognostic (4.90e-2)" "prognostic favorable (7.55e-4)" "unprognostic (8.39e-2)" "unprognostic (8.48e-2)" "unprognostic (1.62e-1)" "unprognostic (1.89e-1)" 1.5 1.9 1.8 1.9 1.6 1.0 1.8 1.8 1.9 1.6 1.7 1.8 2.1 1.8 2.7 2.3 2.6 1.4 1.6 1.6 1.8 1.8 2.5 1.5 2.4 1.5 1.5 2.7 2.2 2.1 1.2 1.8 1.5 1.7 1.6 1.4 2.3 1.8 2.4 2.1 2.2 1.4 1.2 2.3 2.0 5.0 1.8 2.0 2.2 1.4 2.2 1.9 1.3 1.6 3.5 5.9 3.6 5.0 5.0 4.1 6.6 4.1 4.4 10.1 4.3 12.8 5.1 5.3 5.3 3.7 6.6 10.0 3.8 10.1 6.4 1.9 4.0 4.2 4.7 7.4 5.1 4.2 4.3 4.6 8.4 4.2 4.1 3.3 3.5 4.6 6.2 3.1 3.8 5.8 7.0 5.1 5.3 5.4 10.2 2.7 5.6 4.7 4.0 5.4 5.2 6.0 6.4 20.3 6.8 4.0 8.5 8.0 4.2 7.6 4.3 4.2 4.5 7.7 7.4 2.2 6.8 2.5 3.3 2.8 4.1 3.8 3.2 3.8 4.2 4.7 3.4 3.6 4.8 3.3 5.6 4.4 2.1 4.5 5.9 2.6 5.9 3.9 1.8 1.6 1.8 1.9 1.6 1.8 1.5 1.5 1.5 1.2 1.8 1.6 2.2 0.0 1.5 0.3 3.7 1.8 5.0 5.2 5.7 5.6 3.8 3.8 2.0 4.3 4.6 0.0 4.2 10.3 1.3 4.0 1.9 7.8 90.9 7.4 5.3 2.7 2.4 5.2 1.7 8.0 6.3 3.4 2.0 5.5 0.0 6.6 6.1 7.5 4.9 0.0 1.8 3.8 4.1 3.8 1.1 26.2 5.0 3.2 3.6 0.0 5.2 6.9 5.2 0.5 1.0 5.9 2.5 3.0 2.0 3.2 3.7 7.3 7.7 5.9 13.1 2.2 3.3 20.0 7.6 5.4 3.8 11.6 3.1 5.8 4.6 4.8 MOGAT1 "DGAT2L, DGAT2L1, MGAT1" ENSG00000124003 "Monoacylglycerol O-acyltransferase 1" Q96PD6 2 222671658-222709930 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycerol metabolism, Lipid biosynthesis, Lipid metabolism" "Acyltransferase, Transferase" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enriched" "Detected in some" 5 "gallbladder: 16.8" "Cell type enhanced" "Detected in some" "Astrocytes: 8.1;Breast glandular cells: 7.2;Cholangiocytes: 7.2;Endometrial ciliated cells: 3.9;Exocrine glandular cells: 5.1;Glandular and luminal cells: 4.9;Hepatocytes: 3.2" "Cancer enhanced" "Detected in some" "pancreatic cancer: 0.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA049944, HPA076308" Uncertain Approved "Endoplasmic reticulum,Cytosol" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 30: Mammary glandular cells - Lactation" Cytosol "Endoplasmic reticulum" "HPA049944: AB_2680964, HPA076308: " "unprognostic (6.32e-2)" "unprognostic (2.38e-1)" "unprognostic (1.15e-1)" "unprognostic (1.41e-1)" "unprognostic (4.28e-3)" "unprognostic (4.39e-2)" "unprognostic (4.32e-2)" "unprognostic (9.44e-2)" "unprognostic (1.91e-1)" "unprognostic (8.59e-2)" "unprognostic (3.07e-3)" "unprognostic (4.99e-2)" "unprognostic (3.89e-1)" "unprognostic (9.03e-3)" 0.9 0.0 0.1 0.0 0.1 0.0 0.4 0.0 0.4 0.0 0.0 0.0 0.0 0.5 0.6 0.1 0.0 16.8 0.4 0.1 0.1 0.8 3.1 0.4 0.0 0.1 0.6 0.0 0.2 0.6 0.0 0.0 0.2 0.1 0.0 0.1 0.5 0.1 0.4 0.6 0.0 0.0 0.1 0.0 0.4 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.1 0.1 0.0 0.4 0.1 0.1 0.1 0.6 0.2 0.1 0.1 0.1 0.0 0.0 0.5 8.1 0.0 0.0 0.0 0.0 0.0 0.4 7.2 0.3 0.7 7.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 1.6 0.9 3.9 0.6 0.1 0.0 0.0 2.5 5.1 0.0 0.1 0.0 4.9 0.0 0.2 0.0 3.2 0.9 0.0 1.9 0.0 0.0 0.3 0.3 0.1 0.0 1.3 0.0 0.0 0.6 1.5 0.0 1.0 0.2 0.6 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.1 0.0 0.9 0.1 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 MOGAT2 "DGAT2L5, FLJ22644, MGAT2" ENSG00000166391 "Monoacylglycerol O-acyltransferase 2" Q3SYC2 11 75717838-75732958 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycerol metabolism, Lipid biosynthesis, Lipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 19 "intestine: 48.2;liver: 25.2" "Cell type enhanced" "Detected in some" "Distal enterocytes: 73.8;Hepatocytes: 79.6;Intestinal goblet cells: 36.2;Proximal enterocytes: 159.6;Undifferentiated cells: 32.4" "Cancer enhanced" "Detected in many" "liver cancer: 6.3" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "Hep G2: 4.5;RPMI-8226: 2.0" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA028834 Uncertain NA NA "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 45: Enterocytes - Digestion" "HPA028834: AB_10601865" "unprognostic (5.63e-2)" "unprognostic (2.71e-2)" "unprognostic (6.37e-2)" "unprognostic (6.88e-3)" "unprognostic (1.15e-4)" "unprognostic (2.66e-3)" "unprognostic (1.28e-3)" "unprognostic (1.09e-1)" "unprognostic (1.42e-2)" "unprognostic (1.12e-1)" "unprognostic (4.21e-2)" "unprognostic (3.02e-1)" "unprognostic (1.24e-5)" "unprognostic (2.13e-3)" "unprognostic (1.84e-2)" "unprognostic (2.13e-1)" "unprognostic (2.83e-3)" 0.0 0.0 0.0 1.9 0.2 0.0 1.4 0.0 0.1 0.1 0.0 13.9 44.9 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.3 25.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 12.6 0.0 0.2 0.2 0.0 0.6 48.2 0.7 0.0 0.0 0.8 0.0 0.1 0.0 0.0 0.0 0.2 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 4.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.1 0.0 0.5 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 1.7 0.6 0.3 1.5 0.2 0.0 0.0 0.0 0.0 73.8 0.0 0.0 0.0 0.1 0.0 0.0 2.4 2.7 0.0 0.5 0.0 0.0 2.6 0.1 0.0 0.0 0.4 79.6 0.0 0.0 0.0 36.2 0.0 0.8 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 21.3 0.0 0.0 0.6 159.6 3.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 32.4 0.1 MOGAT3 "DC7, DGAT2L2, MGAT3" ENSG00000106384 "Monoacylglycerol O-acyltransferase 3" Q86VF5 7 101195007-101201038 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycerol metabolism, Lipid biosynthesis, Lipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 13 "intestine: 24.4;liver: 18.9" "Group enriched" "Detected in some" 4 "Distal enterocytes: 81.9;Paneth cells: 56.3;Proximal enterocytes: 88.9;Undifferentiated cells: 26.3" "Group enriched" "Detected in many" 5 "colorectal cancer: 11.0;liver cancer: 11.1;stomach cancer: 3.2" "Low region specificity" "Detected in some" "Immune cell enhanced" "Detected in single" "neutrophil: 1.6" "Low lineage specificity" "Detected in single" "Group enriched" "Detected in some" 8 "CACO-2: 2.9;Hep G2: 10.7" HPA011940 Approved Approved Centrosome NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 53: Intestinal epithelial cells - Unknown function" Centrosome "HPA011940: AB_1854057" "unprognostic (1.19e-1)" "unprognostic (1.13e-1)" "unprognostic (7.14e-2)" "unprognostic (6.11e-2)" "unprognostic (3.20e-1)" "unprognostic (9.54e-3)" "unprognostic (9.36e-2)" "unprognostic (3.08e-1)" "unprognostic (1.05e-3)" "unprognostic (1.87e-1)" "unprognostic (1.23e-1)" "unprognostic (9.66e-2)" "unprognostic (1.65e-1)" "unprognostic (2.59e-2)" 0.1 0.1 0.5 1.7 0.4 0.9 0.1 1.4 0.7 0.0 0.2 13.4 24.4 0.2 0.2 0.2 0.1 0.2 0.1 0.5 0.2 1.2 18.9 0.1 0.2 0.3 0.1 0.0 0.2 0.0 0.0 0.1 0.4 0.1 7.2 0.4 0.1 0.1 0.5 0.4 23.8 0.8 0.0 0.2 0.2 0.1 0.4 0.1 0.1 0.0 0.0 0.1 0.0 1.1 0.4 0.1 0.1 0.2 0.0 0.0 0.2 0.4 0.0 0.0 0.0 2.9 0.8 0.1 0.4 0.0 0.3 0.2 0.1 0.0 0.1 0.0 0.0 0.3 0.4 10.7 0.1 0.2 0.2 0.0 0.1 0.0 0.1 0.2 0.0 0.1 0.1 0.3 0.0 0.1 0.2 0.3 0.1 0.3 0.4 0.1 0.0 0.3 0.4 0.4 0.1 0.1 0.1 0.3 0.0 0.4 0.1 0.1 0.6 0.6 0.1 0.6 0.3 0.2 0.1 0.0 0.6 0.3 0.8 0.8 0.2 0.3 0.2 0.2 0.1 0.3 0.2 0.2 0.1 0.4 0.2 0.3 1.6 0.5 0.2 0.3 0.1 0.1 0.5 0.4 1.4 0.7 0.5 0.2 0.3 0.1 0.4 0.0 0.4 1.1 0.3 0.0 0.5 0.0 0.1 0.0 0.6 0.0 0.0 0.0 0.1 0.3 0.4 0.0 0.0 0.0 0.0 0.1 0.0 81.9 0.0 0.1 0.0 0.1 0.2 0.1 1.8 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.0 0.1 1.1 7.4 0.0 0.0 0.0 14.7 0.0 0.0 0.4 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 56.3 0.0 0.0 0.2 88.9 5.0 0.0 0.0 0.0 0.8 0.2 0.0 0.1 0.0 0.1 0.1 0.5 0.1 26.3 0.4 MOK "RAGE, RAGE1, STK30" ENSG00000080823 "MOK protein kinase" Q9UQ07 14 102224500-102305190 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "retina: 125.8;testis: 54.0" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 185.6;Early spermatids: 212.8;Late spermatids: 185.8;Respiratory ciliated cells: 156.9;Rod photoreceptor cells: 465.7" "Cancer enriched" "Detected in many" 4 "melanoma: 7.4" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "NK-cell: 8.0" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HBF TERT88: 149.0;hTEC/SVTERT24-B: 383.5;NB-4: 499.1;U-138 MG: 200.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027292 Supported "Endoplasmic reticulum" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 77: Retina - Visual perception" "Cluster 24: NB-4 - Immune response" "Cluster 46: Photoreceptor cells - Phototransduction" "Endoplasmic reticulum" "HPA027292: AB_10600989" "unprognostic (8.16e-2)" "unprognostic (1.82e-1)" "unprognostic (6.68e-2)" "unprognostic (6.05e-3)" "unprognostic (1.34e-2)" "unprognostic (1.81e-2)" "unprognostic (4.43e-2)" "unprognostic (3.49e-4)" "unprognostic (2.19e-1)" "unprognostic (2.03e-2)" "unprognostic (2.93e-1)" "unprognostic (3.01e-3)" "unprognostic (5.97e-2)" "unprognostic (1.81e-1)" "unprognostic (2.17e-1)" "unprognostic (1.26e-2)" "unprognostic (2.48e-1)" 9.2 11.2 15.7 1.8 16.0 3.0 6.8 14.8 18.6 8.9 26.9 5.3 3.4 7.8 7.3 4.3 21.2 4.6 13.0 17.2 16.9 12.6 5.8 5.3 1.7 16.2 17.2 12.9 9.7 7.1 18.6 2.4 15.9 7.6 1.8 125.8 6.3 3.5 2.2 6.8 3.0 3.9 15.0 4.7 9.3 54.0 17.1 1.7 14.8 0.7 1.3 8.4 5.5 15.6 18.9 16.5 2.2 9.5 3.8 13.1 4.2 37.7 11.0 53.4 63.7 1.5 45.4 14.5 3.1 7.2 11.5 4.1 3.3 19.4 149.0 16.2 14.1 3.4 2.3 12.7 15.9 1.6 17.9 11.1 4.9 383.5 35.3 41.3 2.0 2.9 3.4 1.0 35.3 12.5 1.2 499.1 0.7 8.3 39.4 2.2 1.0 0.3 21.9 0.8 6.0 3.9 6.8 2.6 109.4 0.8 11.2 1.5 1.4 200.4 10.4 7.7 12.1 1.3 2.4 1.2 40.2 1.2 93.1 0.0 0.7 0.0 0.5 0.6 0.8 0.0 0.4 1.4 3.0 0.5 0.7 1.7 0.5 8.0 0.1 0.0 0.0 0.9 15.7 16.0 14.8 18.6 17.2 16.9 16.2 17.2 15.9 15.0 17.1 15.6 5.8 19.2 17.5 68.6 1.0 10.7 6.3 12.0 7.4 40.9 19.1 17.3 12.3 10.0 27.5 12.9 185.6 1.4 2.4 6.1 5.9 8.3 212.8 122.1 16.9 7.2 4.8 3.6 54.7 16.0 2.6 17.6 12.2 10.7 3.8 12.2 8.6 2.0 2.1 16.8 37.5 2.4 6.1 1.3 5.3 185.8 30.4 2.5 80.0 7.5 0.5 59.5 1.0 16.1 6.8 6.5 1.2 16.1 1.1 2.7 3.5 11.1 156.9 465.7 26.3 22.4 13.4 121.4 32.0 5.4 5.8 1.2 4.2 13.4 4.2 3.8 MOS ENSG00000172680 "MOS proto-oncogene, serine/threonine kinase" P00540 8 56112942-56113982 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" Proto-oncogene "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Group enriched" "Detected in some" 7 "Early spermatids: 6.5;Spermatocytes: 3.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" NA NA "Cluster 66: Spermatocytes - Spermatogenesis" "unprognostic (3.28e-1)" 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 MPST "MST, TST2, TUM1" ENSG00000128309 "Mercaptopyruvate sulfurtransferase" P25325 22 37019635-37029821 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 390.7" "Cell type enhanced" "Detected in many" "Distal enterocytes: 553.6;Hepatocytes: 578.6;Paneth cells: 621.4;Proximal enterocytes: 1322.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001240 Enhanced Approved Mitochondria,Cytosol NA NA 2900000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 85: Liver - Metabolism" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 45: Enterocytes - Digestion" Mitochondria Cytosol "HPA001240: AB_1079408" "unprognostic (7.18e-3)" "unprognostic (4.45e-1)" "unprognostic (1.80e-1)" "unprognostic (1.30e-3)" "unprognostic (1.73e-3)" "unprognostic (1.43e-1)" "unprognostic (7.07e-2)" "unprognostic (2.15e-1)" "unprognostic (2.22e-1)" "unprognostic (1.35e-1)" "unprognostic (2.25e-1)" "unprognostic (1.58e-1)" "unprognostic (3.15e-3)" "unprognostic (3.98e-2)" "unprognostic (3.51e-1)" "unprognostic (2.52e-1)" "prognostic favorable (5.89e-4)" 58.0 57.3 25.3 10.0 32.3 36.5 51.0 29.0 31.0 40.9 29.8 102.4 106.5 34.7 0.6 91.5 42.9 16.6 64.2 22.9 23.4 71.4 390.7 43.5 8.8 34.0 27.5 81.7 106.4 4.8 14.7 9.1 29.7 45.3 17.0 0.5 43.5 9.6 89.7 82.3 93.0 7.0 26.0 22.1 70.3 51.7 31.4 4.5 24.8 23.1 6.0 48.3 62.3 35.1 44.0 50.4 24.2 50.0 27.8 17.2 38.1 23.4 20.6 24.8 33.2 48.6 18.9 68.7 33.0 16.7 16.7 29.9 20.9 33.8 3.6 41.4 119.2 26.5 21.3 115.6 87.5 29.0 35.6 30.0 64.2 16.1 15.1 22.8 50.6 33.1 48.0 19.3 7.0 33.8 2.6 97.5 45.7 56.7 52.2 73.6 28.8 51.9 25.5 14.0 12.4 92.9 15.6 23.9 46.6 12.2 26.0 45.6 39.8 21.3 60.1 23.9 16.0 33.3 16.8 21.0 7.7 34.7 11.1 48.5 71.9 54.7 31.0 27.5 42.4 24.9 20.1 26.4 104.0 25.0 2.7 10.4 21.9 87.8 12.7 16.3 44.3 35.4 25.3 32.3 29.0 31.0 22.9 23.4 34.0 27.5 29.7 26.0 31.4 35.1 21.3 35.3 61.9 14.7 25.1 81.6 80.4 120.3 70.6 4.5 81.4 83.4 29.4 243.1 70.0 60.7 0.0 61.9 20.3 553.6 133.1 146.4 191.1 38.5 46.8 42.6 108.6 122.6 1.1 148.3 119.1 52.8 87.1 72.5 17.2 140.3 108.5 578.6 77.5 3.3 1.9 363.1 85.5 84.6 77.6 115.1 91.0 62.7 58.7 3.7 60.7 24.8 56.7 4.5 14.9 117.9 621.4 84.7 65.7 77.7 1322.1 469.8 13.4 2.8 46.0 34.4 36.0 101.3 11.5 133.7 152.9 50.1 26.6 57.7 397.5 110.6 MST1R "CD136, CDw136, PTK8, RON, SEA" ENSG00000164078 "Macrophage stimulating 1 receptor" Q04912 3 49887002-49903873 "CD markers, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Immunity, Innate immunity" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skin 1: 62.3;stomach 1: 42.6" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 25.6;Distal enterocytes: 53.9;Gastric mucus-secreting cells: 108.6;Intestinal goblet cells: 25.7;Pancreatic endocrine cells: 31.2;Paneth cells: 30.3;Proximal enterocytes: 27.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A-431: 39.3;CAPAN-2: 98.8;HaCaT: 56.3;HBEC3-KT: 59.4;hTCEpi: 83.4;RT4: 67.9" "Not detected" "Not detected" "Not detected" "Not detected" "HPA007657, HPA008180, CAB008972" Enhanced Approved Cytosol NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 31: Skin - Epidermis development" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "CAB008972: , HPA007657: AB_1079292, HPA008180: AB_1079291" "unprognostic (3.84e-3)" "unprognostic (3.86e-1)" "unprognostic (1.92e-1)" "unprognostic (7.33e-3)" "unprognostic (3.82e-2)" "unprognostic (2.32e-1)" "unprognostic (8.07e-3)" "unprognostic (1.54e-2)" "unprognostic (4.12e-2)" "unprognostic (2.15e-1)" "unprognostic (1.24e-3)" "unprognostic (2.28e-1)" "unprognostic (8.08e-3)" "unprognostic (2.38e-1)" "unprognostic (2.18e-1)" "unprognostic (8.00e-3)" "prognostic favorable (2.33e-5)" 5.1 0.3 1.1 5.1 1.1 0.2 3.8 1.1 1.7 5.7 1.3 26.5 25.2 1.3 1.2 17.5 1.7 11.4 3.2 1.1 0.9 3.4 1.1 9.5 2.5 0.9 0.8 1.0 5.8 0.1 2.7 0.8 0.9 4.7 20.1 0.2 5.4 1.0 1.3 62.3 23.9 2.0 0.8 1.6 42.6 8.4 0.9 8.8 3.4 0.7 5.6 9.2 11.5 1.0 39.3 14.4 0.1 0.6 0.0 0.0 2.2 0.5 0.1 0.0 0.0 4.1 98.8 1.7 8.8 0.5 0.1 56.3 0.0 59.4 0.0 0.9 1.0 0.1 25.9 0.9 0.9 0.0 1.2 0.3 83.4 0.2 11.7 0.2 0.1 0.2 0.8 0.3 0.0 5.1 0.1 0.1 0.3 33.1 34.6 2.9 0.0 1.1 35.8 67.9 1.0 0.1 11.5 22.6 0.2 0.1 17.7 0.9 0.3 0.0 0.3 0.3 0.1 0.5 0.2 0.2 0.3 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.1 1.1 1.1 1.7 1.1 0.9 0.9 0.8 0.9 0.8 0.9 1.0 1.6 25.6 10.3 0.7 1.0 8.8 2.2 14.2 6.8 0.0 2.8 2.5 1.0 0.0 10.6 0.0 0.0 0.1 0.2 53.9 0.0 6.4 15.4 2.9 0.8 0.6 4.2 0.0 1.1 10.0 0.4 0.8 108.6 5.3 0.0 0.1 0.0 0.0 0.1 0.0 1.1 25.7 2.0 0.0 1.4 10.5 0.3 0.5 0.0 1.0 0.6 0.0 1.0 2.0 0.1 31.2 30.3 0.0 0.5 2.2 27.6 0.1 7.6 0.0 0.0 0.5 0.9 1.3 1.5 3.2 4.7 0.0 0.5 0.0 20.1 6.2 MTAP "c86fus, MSAP" ENSG00000099810 "Methylthioadenosine phosphorylase" Q13126 9 21802636-21937651 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Purine salvage" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA046915, CAB080036, CAB080037" Approved Supported Nucleoplasm,Cytosol NA NA 3000000 "Cluster 15: NK-cells - Transcription" "Cluster 89: Fibroblasts - ECM organization" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 22: Epithelial cell types - Mixed function" Cytosol Nucleoplasm "CAB080036: AB_11128130, CAB080037: AB_11129069, HPA046915: AB_2679862" "unprognostic (1.40e-2)" "unprognostic (1.83e-1)" "unprognostic (2.21e-1)" "unprognostic (2.58e-3)" "unprognostic (2.78e-1)" "unprognostic (6.16e-2)" "prognostic unfavorable (4.68e-4)" "unprognostic (9.47e-2)" "unprognostic (2.03e-1)" "unprognostic (8.63e-2)" "unprognostic (4.76e-3)" "unprognostic (4.27e-2)" "unprognostic (6.28e-3)" "unprognostic (2.18e-1)" "unprognostic (1.29e-1)" "unprognostic (1.18e-1)" "unprognostic (1.85e-1)" 5.9 6.5 4.1 5.4 4.8 5.8 8.5 4.2 5.7 7.8 7.6 6.7 4.8 8.8 7.1 8.8 7.1 4.9 7.0 3.8 4.0 6.9 10.9 5.8 6.3 5.0 4.5 12.1 6.6 8.4 2.8 8.9 5.1 7.2 8.0 3.9 6.5 7.0 4.5 7.0 5.9 9.0 4.0 7.3 7.2 2.9 5.4 6.8 7.2 5.4 7.3 10.1 7.4 6.0 30.4 1.0 23.0 19.0 19.4 19.0 28.3 42.3 21.0 21.9 24.3 21.7 14.6 15.3 13.4 21.1 16.3 15.2 24.4 59.5 36.8 0.3 19.8 0.3 56.8 28.8 18.6 24.5 26.3 23.5 0.1 38.6 42.6 24.4 22.6 0.5 0.3 20.1 21.9 3.1 26.8 0.7 27.5 14.7 35.2 0.4 18.0 26.0 18.3 0.4 14.4 15.3 14.4 17.1 21.1 17.9 10.9 0.6 23.8 0.3 15.7 0.2 34.4 13.7 25.5 30.0 0.2 24.3 12.0 1.2 5.6 0.2 3.6 4.5 6.1 5.9 5.3 4.2 6.9 8.4 4.6 4.2 0.7 6.7 2.9 6.3 3.2 2.7 4.1 4.8 4.2 5.7 3.8 4.0 5.0 4.5 5.1 4.0 5.4 6.0 18.8 22.4 19.8 26.1 16.3 14.1 58.4 22.4 16.5 0.0 20.2 23.9 22.4 24.3 27.9 14.7 0.0 52.3 11.4 6.8 15.6 38.6 77.9 28.8 28.5 14.9 9.6 19.1 14.8 28.0 80.0 18.7 15.3 40.6 10.8 30.0 17.5 22.2 27.1 0.0 9.1 14.3 30.5 25.5 11.1 14.8 14.9 15.1 10.6 48.7 15.0 0.0 10.3 40.7 32.9 41.5 6.8 14.7 13.7 45.0 9.2 19.5 19.1 0.0 13.1 20.6 23.1 1.3 13.9 35.1 13.1 22.6 15.1 33.0 20.7 62.9 MTFMT FMT1 ENSG00000103707 "Mitochondrial methionyl-tRNA formyltransferase" Q96DP5 15 65001512-65029639 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Protein biosynthesis" Transferase "Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 49.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040710 Uncertain Approved Nucleoplasm,Cytosol NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 35: Non-specific - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm Cytosol "HPA040710: AB_10794879" "unprognostic (1.20e-1)" "unprognostic (2.72e-2)" "unprognostic (9.28e-3)" "unprognostic (4.35e-2)" "unprognostic (1.28e-1)" "unprognostic (1.42e-2)" "unprognostic (6.63e-2)" "unprognostic (2.02e-1)" "unprognostic (6.95e-2)" "unprognostic (2.18e-2)" "unprognostic (2.41e-2)" "unprognostic (1.78e-1)" "prognostic favorable (3.31e-8)" "unprognostic (2.75e-2)" "unprognostic (4.06e-2)" "unprognostic (3.26e-1)" "unprognostic (1.85e-2)" 1.6 2.2 2.6 0.7 2.9 1.9 1.6 3.8 3.1 2.4 4.0 2.5 1.5 2.5 1.5 2.2 2.6 0.9 4.3 2.5 3.4 2.4 3.5 1.5 1.3 2.5 2.2 2.7 1.4 1.7 2.2 0.8 2.5 2.8 1.5 1.6 1.8 1.3 3.0 1.7 2.2 1.7 1.9 2.3 2.0 1.5 2.9 1.0 1.7 1.5 1.2 2.5 2.1 2.6 1.4 1.9 1.8 3.2 2.5 1.7 1.7 1.3 2.2 1.6 1.5 1.2 1.5 4.7 1.7 2.3 2.7 4.0 3.3 2.2 1.5 1.9 2.8 1.9 1.9 1.3 2.9 2.7 0.6 2.3 2.8 0.9 1.9 2.2 1.5 4.2 2.3 2.2 2.4 1.9 2.3 3.1 2.4 4.0 3.6 2.0 2.5 2.2 2.7 1.6 1.8 1.8 3.1 2.7 2.5 2.2 1.6 2.0 2.8 1.9 1.9 2.4 2.6 1.9 3.1 1.8 1.7 4.6 1.9 3.7 3.3 2.6 4.8 3.1 4.8 4.8 4.7 5.0 6.0 4.7 5.1 5.4 16.5 4.5 2.2 10.1 5.4 2.3 2.6 2.9 3.8 3.1 2.5 3.4 2.5 2.2 2.5 1.9 2.9 2.6 8.5 3.2 9.7 17.0 11.8 3.3 15.2 19.1 14.8 0.0 7.0 7.7 15.8 10.0 10.5 3.7 0.0 11.4 18.1 10.5 25.4 11.8 1.7 7.8 11.6 8.2 7.8 9.4 49.8 10.0 11.7 11.8 8.6 7.0 8.8 8.0 12.8 12.2 16.5 0.0 44.2 8.9 2.0 12.2 12.2 1.7 15.5 9.7 8.8 27.2 7.1 0.0 11.3 19.1 12.9 10.3 15.9 15.4 10.3 16.7 17.5 25.1 5.1 0.0 0.0 12.5 14.5 13.3 20.7 10.7 4.5 8.9 10.1 11.4 15.7 14.5 MTOR "FLJ44809, FRAP, FRAP1, FRAP2, RAFT1, RAPT1" ENSG00000198793 "Mechanistic target of rapamycin kinase" P42345 1 11106535-11262551 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Biological rhythms" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Epilepsy, FDA approved drug targets, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB069425, HPA071227" Approved Approved Vesicles,Cytosol NA NA "Cluster 35: T-regs - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 20: HeLa - Mitochondria" "Cluster 10: Non-specific - Unknown function" "Vesicles, Cytosol" "CAB069425: , HPA071227: AB_2686367" "unprognostic (3.18e-1)" "unprognostic (1.50e-1)" "unprognostic (1.20e-1)" "unprognostic (2.45e-3)" "unprognostic (5.50e-2)" "unprognostic (2.55e-2)" "unprognostic (1.39e-1)" "unprognostic (1.68e-1)" "unprognostic (1.18e-1)" "unprognostic (8.24e-3)" "unprognostic (3.48e-2)" "unprognostic (1.88e-1)" "prognostic favorable (1.49e-5)" "unprognostic (1.27e-1)" "unprognostic (2.45e-1)" "unprognostic (6.60e-2)" "unprognostic (7.55e-2)" 16.3 19.4 18.2 13.5 19.0 14.0 16.8 18.4 20.1 15.2 18.6 22.8 11.0 17.5 21.8 18.3 14.6 9.0 23.6 19.7 17.7 24.1 27.6 15.2 15.3 16.5 21.2 14.2 18.3 20.6 21.8 11.8 18.4 19.8 16.0 26.9 16.5 13.8 36.4 17.1 19.6 13.8 14.6 21.2 18.7 33.8 22.7 19.2 17.8 17.8 15.9 17.1 14.9 18.7 28.5 25.2 33.3 25.4 39.4 18.6 16.6 23.4 22.3 30.6 29.9 26.0 25.5 31.4 19.6 27.8 18.8 33.1 45.3 35.8 39.3 25.2 33.2 41.7 53.8 33.4 24.7 41.1 29.7 24.0 26.8 43.7 44.0 14.5 39.3 29.6 47.4 26.1 21.6 32.4 28.5 31.2 25.3 29.6 23.5 28.2 39.2 21.0 27.2 25.3 33.4 24.5 50.1 26.8 31.2 36.5 21.8 24.0 42.3 26.5 23.9 20.5 31.8 25.5 25.5 60.5 19.1 43.6 28.6 0.3 1.1 1.3 1.9 2.4 1.6 1.4 1.1 1.0 1.6 1.1 1.3 1.1 0.8 1.1 1.3 1.2 2.4 1.0 18.2 19.0 18.4 20.1 19.7 17.7 16.5 21.2 18.4 14.6 22.7 18.7 9.2 16.0 11.8 40.8 10.0 3.4 5.2 7.6 8.6 0.0 7.7 7.5 25.1 2.8 10.3 9.2 0.0 7.9 9.8 9.4 1.9 8.5 42.0 13.8 16.1 11.0 10.3 14.3 43.8 6.2 7.2 9.2 16.8 18.6 13.3 12.9 5.3 13.4 6.9 0.0 49.2 7.8 6.1 8.2 4.1 36.1 7.8 9.1 8.8 36.5 9.2 0.0 10.3 38.2 37.4 10.4 5.4 8.2 17.2 8.9 7.0 4.5 6.3 0.0 39.5 11.4 12.1 49.3 37.4 15.6 5.7 9.9 9.8 15.3 10.0 5.7 MTPAP "FLJ10486, PAPD1, SPAX4, TENT6" ENSG00000107951 "Mitochondrial poly(A) polymerase" Q9NVV4 10 30309801-30374448 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "mRNA processing, Transcription" "Nucleotidyltransferase, RNA-binding, Transferase" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 36.8" "Cell type enriched" "Detected in many" 7 "Early spermatids: 240.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038620, HPA058232" Approved Supported Mitochondria NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 23: Spermatids - Flagellum & Golgi organization" Mitochondria "HPA038620: AB_10673015, HPA058232: AB_2683646" "unprognostic (2.76e-2)" "unprognostic (2.04e-1)" "unprognostic (1.73e-1)" "unprognostic (3.43e-3)" "unprognostic (3.05e-2)" "unprognostic (1.01e-1)" "prognostic unfavorable (4.20e-6)" "unprognostic (1.16e-1)" "unprognostic (2.04e-1)" "unprognostic (4.78e-2)" "unprognostic (1.77e-1)" "unprognostic (3.56e-2)" "unprognostic (9.02e-2)" "unprognostic (6.28e-3)" "unprognostic (3.77e-1)" "unprognostic (1.14e-2)" "unprognostic (4.39e-2)" 8.9 7.4 4.9 10.3 4.8 36.8 9.7 12.6 6.7 6.1 3.1 9.6 10.6 9.0 6.2 8.3 6.6 5.2 8.8 4.8 4.3 9.6 10.6 6.3 10.7 3.4 3.5 8.2 10.0 8.4 2.7 9.6 3.9 7.2 11.0 7.1 8.0 4.9 13.2 8.4 9.0 9.1 3.2 9.3 7.1 5.1 3.6 9.2 10.2 12.0 10.3 8.1 5.2 6.2 26.0 25.3 15.8 23.0 15.2 14.2 20.6 17.6 6.2 17.7 18.4 27.0 35.4 36.9 12.3 11.7 16.3 29.7 31.1 20.7 21.6 18.7 24.0 37.3 23.7 27.5 16.0 24.6 28.2 14.3 19.0 19.9 11.7 9.8 19.6 34.0 41.2 28.1 13.5 21.8 29.8 21.8 10.8 19.5 13.3 29.6 27.9 34.4 16.2 17.1 25.9 20.8 16.0 16.4 24.7 14.8 15.8 15.6 18.7 18.4 23.8 26.0 19.8 6.2 16.3 50.8 15.9 44.5 6.6 27.4 25.2 27.3 21.7 35.0 23.0 20.8 20.4 21.1 33.0 17.1 21.6 22.0 4.2 25.1 27.9 17.3 23.1 13.1 4.9 4.8 12.6 6.7 4.8 4.3 3.4 3.5 3.9 3.2 3.6 6.2 12.2 9.6 7.4 9.1 11.2 25.2 13.9 7.4 4.6 0.0 9.8 9.8 16.7 15.7 9.2 3.7 0.0 13.1 13.9 8.1 19.6 9.6 240.7 9.9 14.8 12.9 4.2 16.6 12.7 9.1 12.0 12.7 7.7 12.5 5.1 18.8 12.5 14.6 14.7 0.0 14.5 15.6 6.1 15.8 13.6 34.3 12.2 10.8 8.8 8.4 14.8 0.0 5.2 4.5 14.4 8.9 5.2 16.6 5.3 14.1 8.7 14.2 8.6 0.0 13.1 14.7 10.8 25.3 19.5 11.4 24.9 11.5 8.8 12.6 18.4 16.6 MTR cblG ENSG00000116984 "5-methyltetrahydrofolate-homocysteine methyltransferase" Q99707 1 236795260-236921278 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Amino-acid biosynthesis, Methionine biosynthesis" "Methyltransferase, Transferase" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 100.0;Glandular and luminal cells: 130.9;Inhibitory neurons: 106.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA044474, HPA054915" Approved Supported Cytosol NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 24: NB-4 - Immune response" "Cluster 44: Endometrium - Transcription" Cytosol "HPA044474: AB_10966696, HPA054915: AB_2732589" "unprognostic (2.12e-1)" "unprognostic (1.03e-1)" "unprognostic (6.96e-2)" "unprognostic (1.99e-1)" "unprognostic (1.35e-1)" "unprognostic (1.76e-1)" "unprognostic (4.87e-1)" "unprognostic (1.02e-1)" "unprognostic (2.48e-2)" "unprognostic (3.34e-1)" "unprognostic (5.73e-2)" "unprognostic (1.63e-1)" "unprognostic (1.67e-2)" "unprognostic (8.84e-3)" "unprognostic (1.88e-1)" "prognostic unfavorable (5.75e-4)" "unprognostic (8.10e-2)" 9.1 6.6 4.3 6.9 5.4 4.6 8.0 5.2 5.4 10.1 6.5 11.1 4.8 10.2 10.5 5.0 11.9 8.9 15.0 4.9 4.6 12.7 6.0 7.1 8.1 6.7 5.3 14.6 13.0 20.2 6.4 11.6 6.9 7.6 5.0 5.6 6.4 9.1 16.6 9.3 7.1 8.7 4.8 9.4 9.0 9.0 4.8 10.0 13.4 18.1 7.0 10.3 7.6 6.5 17.6 11.0 13.0 8.8 22.6 20.3 15.3 14.9 14.8 18.8 19.0 12.6 12.5 40.0 13.2 16.6 8.7 10.6 18.4 13.1 20.4 19.8 13.7 23.7 14.2 18.3 15.1 37.2 13.3 28.9 7.0 22.9 17.9 11.5 22.3 19.8 33.1 16.4 13.1 10.1 19.6 10.3 16.2 12.9 5.4 20.9 24.8 24.2 11.2 21.3 11.1 27.8 17.7 11.9 14.8 9.3 16.7 13.0 28.8 24.1 9.1 19.6 18.8 34.4 12.3 22.7 17.2 21.1 26.2 0.6 0.5 1.5 1.1 0.8 2.3 0.7 1.4 1.4 0.7 0.8 1.4 1.5 0.0 0.9 0.5 0.5 0.9 0.9 4.3 5.4 5.2 5.4 4.9 4.6 6.7 5.3 6.9 4.8 4.8 6.5 23.0 57.7 35.0 53.8 25.8 8.2 8.3 8.3 17.1 0.0 10.7 11.9 100.0 20.0 10.9 40.5 0.0 24.2 25.9 3.4 1.9 13.8 9.8 57.5 80.1 21.4 8.4 23.5 87.7 14.8 9.2 22.8 15.8 130.9 30.4 35.0 15.4 10.8 14.4 0.0 106.8 7.7 4.1 16.6 6.8 6.2 23.9 17.1 10.6 47.8 15.3 0.0 19.6 62.8 73.6 12.3 8.0 33.1 20.3 14.9 9.7 9.1 13.3 0.0 6.6 39.4 23.2 17.2 22.0 11.5 5.1 22.6 26.1 40.2 12.0 6.4 MUL1 "C1orf166, FLJ12875, GIDE, MAPL, MULAN, RNF218" ENSG00000090432 "Mitochondrial E3 ubiquitin protein ligase 1" Q969V5 1 20499448-20508151 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Apoptosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA026827 Approved Nucleoplasm,Mitochondria,Cytosol NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 47: Cytotrophoblasts - Unknown function" "Nucleoplasm, Mitochondria, Cytosol" "HPA026827: AB_10601137" "unprognostic (1.39e-1)" "unprognostic (2.73e-2)" "unprognostic (1.32e-2)" "unprognostic (1.51e-1)" "unprognostic (4.82e-3)" "unprognostic (1.85e-3)" "unprognostic (6.05e-3)" "unprognostic (1.01e-1)" "unprognostic (6.31e-2)" "unprognostic (5.86e-3)" "unprognostic (4.05e-1)" "unprognostic (9.10e-2)" "prognostic favorable (6.15e-14)" "unprognostic (1.59e-2)" "unprognostic (1.10e-1)" "unprognostic (1.05e-2)" "unprognostic (2.37e-1)" 16.7 18.1 18.1 12.0 18.7 28.8 16.2 19.9 19.4 15.9 23.3 21.2 14.2 20.4 11.1 21.2 19.6 14.9 33.7 17.8 19.4 19.5 24.6 15.8 13.6 20.3 19.1 19.1 19.8 36.3 14.6 16.3 20.1 16.0 15.7 7.4 19.3 20.0 35.5 21.8 15.8 20.0 18.7 15.2 18.7 12.2 19.5 12.0 16.2 50.4 15.0 19.2 15.5 19.9 34.1 32.1 18.1 37.9 38.5 21.6 19.6 32.9 39.1 40.1 38.2 19.9 54.8 25.4 35.9 46.8 30.4 50.3 32.9 47.5 28.9 25.4 26.1 19.4 20.4 29.2 45.2 27.0 32.0 35.3 61.6 41.1 42.3 23.4 26.5 22.5 25.8 30.1 44.1 17.3 16.4 18.1 18.7 28.1 30.3 15.8 22.8 32.9 47.1 18.7 18.4 27.3 29.6 31.2 40.5 14.6 22.0 25.6 30.2 38.8 22.3 34.1 29.9 34.9 32.9 27.3 30.4 36.1 36.7 36.2 30.0 38.2 33.1 34.7 34.4 25.3 24.8 33.8 29.6 22.8 28.1 27.6 26.7 32.3 30.7 22.8 37.9 34.0 18.1 18.7 19.9 19.4 17.8 19.4 20.3 19.1 20.1 18.7 19.5 19.9 14.5 22.4 10.3 10.4 9.8 5.2 9.2 13.9 5.2 13.5 12.3 11.9 16.6 10.0 9.5 18.4 6.2 37.1 13.2 21.6 11.7 26.3 2.2 7.7 9.5 13.1 8.5 8.6 4.9 23.4 22.5 13.9 7.7 9.4 3.8 14.7 13.6 17.6 23.0 13.5 6.8 12.9 16.2 10.0 6.5 4.0 13.1 9.3 19.6 2.8 15.5 16.0 16.5 5.5 6.0 25.6 14.6 15.4 13.1 9.2 13.2 10.6 9.6 11.9 19.7 11.9 14.7 14.6 15.4 7.4 7.1 37.6 9.2 18.0 12.2 10.7 MUSK ENSG00000030304 "Muscle associated receptor tyrosine kinase" O15146 9 110668779-110806558 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters" Differentiation "Developmental protein, Kinase, Muscle protein, Receptor, Transferase, Tyrosine-protein kinase" "Congenital myasthenic syndrome, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 6.2;skeletal muscle: 4.1" "Cell type enhanced" "Detected in some" "Late spermatids: 4.8;Leydig cells: 5.3;Oligodendrocytes: 17.0;Peritubular cells: 19.5;Skeletal myocytes: 23.1" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 16 "LHCN-M2: 24.7;RH-30: 23.7" "Region enhanced" "Detected in some" "basal ganglia: 5.0" "Not detected" "Not detected" NA NA "Cluster 70: Brain - Nervous system development" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 50: Fibroblasts - ECM organization" "unprognostic (6.12e-2)" "unprognostic (9.01e-2)" "unprognostic (5.39e-2)" "unprognostic (3.66e-1)" "unprognostic (3.14e-1)" "unprognostic (1.20e-2)" "unprognostic (1.50e-2)" "unprognostic (2.46e-1)" "unprognostic (3.13e-1)" "unprognostic (7.58e-2)" "unprognostic (6.03e-5)" "unprognostic (4.58e-2)" "unprognostic (1.62e-1)" "unprognostic (9.67e-2)" "unprognostic (5.11e-2)" 0.1 0.2 1.5 1.7 3.0 0.0 0.0 0.8 1.5 0.0 1.6 1.9 1.1 0.0 0.0 1.4 0.0 1.1 1.5 1.2 1.1 0.0 0.3 1.0 0.6 2.7 6.2 0.1 0.1 0.0 0.0 0.3 1.7 0.2 2.5 0.0 0.1 0.0 4.1 0.1 2.4 0.5 2.9 0.0 1.3 1.6 2.0 0.1 0.0 2.0 2.0 1.2 0.0 4.9 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.4 0.0 0.0 1.5 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 24.7 0.0 0.0 0.0 0.5 0.0 0.2 0.0 23.7 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 3.0 0.8 1.5 1.2 1.1 2.7 6.2 1.7 2.9 2.0 4.9 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 3.5 0.0 0.3 0.1 0.0 0.0 1.3 0.0 0.0 4.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 4.8 5.3 0.0 0.0 1.9 0.0 0.0 0.0 2.5 17.0 0.0 0.0 19.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 23.1 0.1 0.5 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 MVK "LRBP, MK" ENSG00000110921 "Mevalonate kinase" Q03426 12 109573255-109598125 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" "Kinase, Transferase" "Cataract, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 69.1" "Cell type enhanced" "Detected in all" "Early spermatids: 60.5;Horizontal cells: 62.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016961, HPA044110" Approved Supported Vesicles,Cytosol NA NA "Cluster 24: B-cells - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 15: Hepatocytes - Hemostasis" "Vesicles, Cytosol" "HPA016961: AB_1854220, HPA044110: " "unprognostic (3.10e-1)" "unprognostic (2.27e-2)" "unprognostic (1.85e-1)" "unprognostic (4.43e-2)" "unprognostic (3.66e-2)" "unprognostic (2.08e-2)" "unprognostic (4.30e-2)" "unprognostic (8.98e-2)" "unprognostic (1.05e-1)" "unprognostic (2.73e-2)" "unprognostic (8.23e-2)" "unprognostic (1.30e-1)" "unprognostic (6.43e-2)" "unprognostic (2.09e-1)" "unprognostic (1.58e-1)" "unprognostic (3.88e-1)" "unprognostic (3.28e-1)" 7.9 29.8 12.7 6.1 13.7 8.3 14.7 16.7 15.0 14.5 9.6 11.2 13.9 7.3 10.2 45.5 6.3 5.3 9.4 11.1 13.2 32.1 69.1 11.4 6.9 36.1 15.5 10.7 10.0 11.5 11.6 5.4 38.6 12.3 8.6 7.3 13.7 7.0 12.1 33.3 9.8 5.0 15.3 6.7 11.8 28.5 15.3 4.2 15.1 8.8 9.1 9.5 20.1 24.4 30.1 25.0 29.9 13.7 11.2 27.3 14.4 9.5 21.7 30.0 32.8 31.4 33.8 17.7 7.8 11.7 48.1 36.0 31.6 50.0 13.2 19.0 18.1 9.9 15.7 53.7 31.5 11.1 13.0 27.2 42.1 48.8 13.6 12.6 20.9 19.0 18.7 17.4 13.6 34.5 12.0 34.6 22.6 14.9 32.3 10.5 22.1 37.0 67.4 40.9 25.1 18.7 19.8 58.7 14.0 11.0 59.7 21.1 14.1 13.2 14.5 12.0 12.8 13.3 20.6 28.2 16.1 29.2 16.6 1.0 6.9 4.0 12.6 6.5 11.3 9.4 7.4 12.4 8.6 14.1 10.9 8.3 1.6 11.0 4.6 7.0 7.6 6.4 12.7 13.7 16.7 15.0 11.1 13.2 36.1 15.5 38.6 15.3 15.3 24.4 6.1 12.8 12.4 6.8 8.3 4.7 5.2 39.7 4.6 12.4 13.1 11.0 5.7 11.5 25.8 14.7 18.8 33.0 7.3 10.4 21.5 15.6 60.5 5.8 2.3 7.1 9.0 4.8 5.1 18.1 15.3 6.8 9.7 5.1 1.3 14.7 6.4 32.7 15.6 62.2 5.2 7.8 10.2 3.4 2.2 42.5 8.1 4.8 7.2 3.7 10.3 10.6 10.3 4.0 15.3 13.2 3.2 7.2 4.1 5.5 16.4 52.4 13.5 12.2 6.6 4.0 8.2 33.9 16.8 12.0 8.5 47.9 6.1 44.8 11.1 4.6 MYCBP2 "FLJ10106, KIAA0916, PAM, PHR1" ENSG00000005810 "MYC binding protein 2" O75592 13 77044657-77327094 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Biological rhythms, Ubl conjugation pathway" "Guanine-nucleotide releasing factor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 425.4;Inhibitory neurons: 471.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HL-60: 110.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA058807 Supported Nucleoplasm,Vesicles,Cytosol "Intracellular and membrane" NA NA "Cluster 37: B-cells - Transcription" "Cluster 27: Brain & Skin - Unknown function" "Cluster 32: U-937 - Innate immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "Vesicles, Cytosol" "HPA058807: AB_2732627" "unprognostic (1.79e-1)" "unprognostic (1.25e-1)" "unprognostic (1.60e-1)" "unprognostic (1.06e-1)" "unprognostic (1.75e-1)" "unprognostic (2.03e-2)" "unprognostic (8.36e-2)" "unprognostic (1.21e-1)" "unprognostic (1.09e-1)" "unprognostic (1.80e-1)" "unprognostic (1.48e-1)" "unprognostic (6.42e-2)" "prognostic favorable (5.01e-5)" "unprognostic (2.63e-1)" "unprognostic (9.84e-2)" "unprognostic (4.04e-2)" "unprognostic (1.00e-1)" 69.9 22.2 42.3 19.0 46.2 32.8 49.3 37.3 52.4 43.4 18.8 29.4 9.0 27.2 29.8 45.9 29.2 12.5 32.9 48.6 35.9 22.6 24.5 28.3 40.0 34.6 29.6 43.1 30.9 14.9 32.3 10.9 36.9 28.0 12.5 28.9 29.1 13.3 26.5 79.7 34.8 11.9 30.1 56.4 24.9 26.3 33.9 34.6 27.2 18.1 37.8 30.4 41.5 38.7 21.6 10.8 12.9 14.1 62.9 27.9 7.5 13.4 19.8 11.5 14.7 9.7 11.0 61.4 8.3 26.6 11.2 19.5 22.4 24.7 15.5 24.5 22.2 52.2 22.2 20.1 21.4 110.8 17.7 31.5 20.2 10.6 20.8 11.4 26.5 22.3 11.3 18.8 20.7 13.1 30.5 74.3 6.8 28.7 13.6 34.2 13.1 15.0 19.6 21.1 20.2 9.4 16.2 23.1 12.8 13.0 8.6 83.8 35.0 10.9 9.1 7.3 13.0 20.3 15.0 42.7 22.1 89.2 11.3 1.4 2.0 2.0 3.2 2.1 2.8 4.9 3.6 2.8 1.9 4.3 4.1 3.2 1.8 2.8 1.6 2.7 4.5 1.4 42.3 46.2 37.3 52.4 48.6 35.9 34.6 29.6 36.9 30.1 33.9 38.7 92.2 38.5 52.2 158.7 170.3 82.3 39.9 32.6 63.7 229.3 36.8 38.4 69.7 25.8 30.9 35.0 104.3 46.1 109.2 14.2 1.9 26.1 56.0 50.9 61.1 83.8 32.6 46.9 425.4 33.1 31.5 80.6 38.2 66.6 48.2 34.0 44.6 52.4 41.8 218.7 471.3 19.7 26.4 106.9 48.2 23.4 65.9 100.4 32.0 282.9 116.7 121.5 120.5 338.8 212.5 30.2 15.8 96.3 121.9 53.7 15.2 13.2 19.5 94.8 105.2 76.7 76.0 81.5 71.6 129.1 150.7 43.9 121.5 67.4 28.1 42.4 MYLIP "IDOL, MIR" ENSG00000007944 "Myosin regulatory light chain interacting protein" Q8WY64 6 16129086-16148248 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Syncytiotrophoblasts: 352.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "RPMI-8226: 57.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 25: RPMI-8226 - Immune response" "Cluster 7: Non-specific - Mitochondria" "unprognostic (1.54e-1)" "unprognostic (4.84e-3)" "unprognostic (2.79e-1)" "unprognostic (9.65e-3)" "unprognostic (1.07e-1)" "unprognostic (2.07e-2)" "unprognostic (1.11e-2)" "prognostic favorable (6.44e-6)" "unprognostic (2.75e-2)" "unprognostic (2.67e-2)" "unprognostic (5.44e-3)" "unprognostic (1.03e-2)" "prognostic favorable (3.67e-4)" "unprognostic (1.42e-2)" "unprognostic (1.47e-1)" "unprognostic (2.35e-1)" "prognostic favorable (4.11e-5)" 37.0 18.9 12.8 12.8 20.0 92.1 30.2 12.5 16.4 42.2 13.6 24.3 12.9 40.3 30.6 18.1 32.6 21.3 14.2 13.4 13.3 21.6 4.9 29.5 22.8 13.7 14.3 35.8 15.5 24.6 8.2 63.4 12.0 16.4 16.5 4.7 25.7 23.1 41.1 25.7 24.5 28.4 12.3 30.8 22.7 15.0 15.7 15.2 50.2 22.8 15.4 25.0 24.7 22.4 3.4 6.0 2.8 3.3 28.3 6.9 7.3 2.4 5.4 5.4 12.0 18.4 3.3 16.0 11.5 3.9 4.0 8.2 13.0 4.4 4.9 5.2 12.8 10.2 7.1 3.8 4.1 7.4 10.0 11.5 5.5 2.6 2.2 2.8 12.5 3.4 29.8 18.6 2.1 12.6 0.2 40.6 8.0 8.4 5.7 3.5 12.9 57.9 6.7 40.0 13.5 6.2 2.9 31.2 17.1 23.9 5.8 18.8 3.5 2.6 6.2 2.2 6.1 16.0 7.5 8.1 1.6 20.9 9.0 6.1 1.5 7.8 5.8 1.8 5.4 4.2 3.7 4.1 1.1 3.3 4.0 3.9 9.4 2.6 1.5 0.5 2.3 1.2 12.8 20.0 12.5 16.4 13.4 13.3 13.7 14.3 12.0 12.3 15.7 22.4 102.6 22.4 50.2 5.5 67.7 98.0 38.9 8.8 126.3 9.3 67.6 117.0 90.7 50.1 17.7 22.0 0.0 134.2 78.5 49.5 9.8 22.1 47.5 82.7 56.2 70.9 84.3 52.6 17.1 18.4 80.0 79.6 54.0 77.7 35.5 35.1 41.4 1.4 32.0 11.8 8.4 41.1 10.2 61.7 121.2 20.2 38.5 56.0 80.0 7.5 27.3 16.9 56.7 3.0 55.3 7.6 32.4 61.7 30.2 28.1 27.8 21.1 25.7 7.8 138.1 90.8 96.7 53.0 22.6 100.9 84.0 352.3 103.8 3.9 45.4 35.1 MYLK "MLCK, MLCK1, MYLK1, smMLCK" ENSG00000065534 "Myosin light chain kinase" Q15746 3 123610049-123884332 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Actin-binding, Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Aortic aneurysm, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "seminal vesicle: 1700.3;smooth muscle: 2137.7" "Cell type enhanced" "Detected in many" "Breast myoepithelial cells: 728.5;Hepatocytes: 208.7;Peritubular cells: 690.5;Sertoli cells: 276.1;Smooth muscle cells: 448.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "basophil: 7.4" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "BJ: 200.0;BJ hTERT+: 298.2;fHDF/TERT166: 260.2;hTERT-RPE1: 202.7;RPTEC TERT1: 291.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB020789, HPA031677, HPA048055" Enhanced Enhanced "Plasma membrane,Actin filaments" NA NA 1500000 "Cluster 34: Basophils - Unknown function" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 48: Smooth muscle cells - ECM organization" "Actin filaments" "Plasma membrane" "CAB020789: , HPA031677: AB_10794617, HPA048055: AB_2732543" "unprognostic (2.80e-2)" "unprognostic (5.05e-2)" "unprognostic (5.55e-2)" "unprognostic (2.85e-2)" "unprognostic (1.69e-1)" "unprognostic (1.41e-1)" "unprognostic (4.86e-2)" "unprognostic (8.55e-2)" "unprognostic (1.20e-1)" "unprognostic (1.40e-1)" "unprognostic (8.21e-2)" "unprognostic (1.58e-1)" "prognostic unfavorable (2.04e-6)" "unprognostic (5.26e-3)" "unprognostic (9.60e-2)" "unprognostic (3.00e-1)" "prognostic unfavorable (4.46e-4)" 143.6 57.4 37.6 188.7 64.8 3.3 163.4 72.1 42.4 281.3 14.1 551.5 110.9 669.2 232.9 420.6 289.8 250.4 33.6 33.6 46.7 64.4 67.2 85.2 33.6 104.6 64.8 95.9 15.3 11.6 2.6 70.2 99.3 907.6 299.1 13.6 140.1 1700.3 10.0 20.1 125.1 2137.7 55.6 89.5 122.7 50.5 52.2 8.0 22.2 14.9 19.1 505.7 84.8 112.1 14.4 38.4 10.8 7.8 10.8 1.9 4.7 200.0 298.2 137.3 92.1 8.1 7.4 0.6 42.5 260.2 67.0 4.8 5.2 1.8 149.0 0.2 0.7 102.4 0.9 28.9 56.1 0.6 9.8 36.9 3.5 24.4 34.4 202.7 8.9 1.3 1.2 0.5 90.9 1.7 0.2 2.5 12.0 0.5 5.1 13.5 6.8 36.7 291.9 8.5 1.4 6.4 21.8 1.9 3.1 25.0 1.0 0.3 33.4 39.5 13.9 10.3 30.7 3.4 4.2 0.3 104.0 1.0 9.6 7.4 1.6 0.4 0.1 0.2 0.0 0.2 0.0 0.0 3.5 0.1 0.2 0.1 5.0 0.0 0.0 3.3 0.2 20.9 37.6 64.8 72.1 42.4 33.6 46.7 104.6 64.8 99.3 55.6 52.2 112.1 45.9 16.0 38.3 43.4 2.5 20.5 27.2 24.8 1.2 2.9 19.9 728.5 25.2 37.1 5.7 27.6 125.1 0.8 3.5 88.1 3.9 6.0 40.7 45.9 46.6 56.9 11.4 3.2 25.2 3.9 0.8 40.1 3.1 54.4 2.5 3.2 45.3 208.7 4.9 3.3 3.4 3.9 8.2 7.9 37.0 33.8 104.7 20.8 19.6 8.4 1.2 4.7 0.0 5.5 37.0 4.0 18.7 690.5 3.3 8.6 14.2 17.2 17.6 19.9 276.1 5.6 448.7 4.7 4.6 1.3 20.2 2.5 3.2 4.5 4.2 3.7 MYLK2 "KMLC, MLCK2, skMLCK" ENSG00000101306 "Myosin light chain kinase 2" Q9H1R3 20 31819308-31834689 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Cardiomyopathy, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 12 "skeletal muscle: 732.0" "Cell type enriched" "Detected in some" 5 "Skeletal myocytes: 15.9" "Cancer enhanced" "Detected in some" "glioma: 1.6" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "Karpas-707: 4.1;RH-30: 10.5;RPMI-8226: 8.8" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA059704, HPA059890" Enhanced Supported "Endoplasmic reticulum" NA NA "Cluster 33: Striated muscle - Muscle contraction" "Cluster 25: RPMI-8226 - Immune response" "Cluster 37: Myocytes - Muscle contraction" "Endoplasmic reticulum" "HPA059704: AB_2684108, HPA059890: AB_2684153" "unprognostic (1.74e-2)" "unprognostic (1.87e-1)" "unprognostic (8.84e-2)" "unprognostic (5.27e-2)" "prognostic favorable (4.00e-4)" "unprognostic (5.58e-2)" "unprognostic (1.38e-7)" "unprognostic (2.29e-1)" "unprognostic (2.60e-3)" "unprognostic (1.99e-1)" "unprognostic (1.20e-1)" "unprognostic (4.73e-2)" "unprognostic (7.25e-11)" "unprognostic (2.01e-1)" "unprognostic (3.15e-1)" "unprognostic (2.60e-2)" "unprognostic (2.70e-2)" 0.1 0.0 0.6 0.1 0.6 0.4 0.1 0.6 0.7 0.0 0.5 0.2 0.0 0.1 0.1 4.7 0.1 0.0 0.3 0.6 0.6 0.0 0.0 0.1 0.0 0.6 0.7 0.1 5.5 0.0 0.1 0.0 0.7 1.1 0.0 0.0 2.4 0.0 732.0 0.6 0.1 0.1 0.6 0.3 0.2 0.2 0.7 0.2 0.2 60.3 0.0 0.0 0.0 0.6 0.3 0.0 0.7 0.6 0.0 0.0 0.4 0.1 0.0 0.3 0.0 0.2 0.2 0.5 0.3 0.0 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.6 0.3 0.0 0.0 0.5 0.1 0.0 0.0 0.3 0.0 1.3 0.8 0.5 0.1 4.1 0.1 0.6 0.5 0.3 0.5 0.0 0.3 0.6 10.5 8.8 0.0 0.1 0.5 0.5 2.7 0.1 0.0 0.1 0.1 0.1 2.1 0.2 0.7 0.4 2.4 0.0 0.8 0.2 0.1 2.5 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.6 0.6 0.7 0.6 0.6 0.6 0.7 0.7 0.6 0.7 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 1.2 0.0 0.0 0.1 0.4 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 1.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 2.8 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.9 0.3 0.3 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 MYLK3 "caMLCK, MLCK" ENSG00000140795 "Myosin light chain kinase 3" Q32MK0 16 46702282-46790407 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "heart muscle: 103.4;skeletal muscle: 46.5;tongue: 72.6" "Group enriched" "Detected in some" 12 "Cardiomyocytes: 169.0;Endometrial ciliated cells: 44.8" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 12.9;HEL: 40.2;K-562: 6.5;SK-BR-3: 7.9" "Group enriched" "Detected in some" 7 "cerebral cortex: 9.6;hippocampal formation: 5.1" "Region enriched" "Detected in single" 5 "hippocampal formation: 3.5" HPA073447 Enhanced Approved Nucleoplasm,Vesicles NA NA "Cluster 38: Heart - Muscle contraction" "Cluster 36: HEL - Hemostasis" "Cluster 54: Cardiomyocytes - Muscle contraction" Nucleoplasm Vesicles "HPA073447: AB_2732225" "unprognostic (6.01e-4)" "unprognostic (2.19e-1)" "unprognostic (2.64e-1)" "unprognostic (1.77e-2)" "unprognostic (1.84e-1)" "unprognostic (2.94e-3)" "unprognostic (2.60e-1)" "unprognostic (4.73e-2)" "unprognostic (3.33e-2)" "unprognostic (2.41e-2)" "unprognostic (6.58e-3)" "unprognostic (1.83e-1)" "unprognostic (4.16e-2)" "unprognostic (2.57e-2)" "unprognostic (2.52e-1)" "unprognostic (1.08e-2)" "unprognostic (2.97e-1)" 0.0 0.1 1.9 0.1 1.7 0.3 0.1 1.1 2.3 0.4 1.7 0.0 0.1 0.3 0.8 4.3 1.7 0.2 103.4 2.5 2.8 1.1 0.1 0.4 0.2 9.8 12.2 0.3 0.1 0.0 0.4 0.5 8.2 2.2 0.1 0.2 2.1 0.1 46.5 0.1 0.1 0.2 5.9 0.1 0.1 6.0 1.9 0.1 0.1 72.6 0.1 0.0 0.0 3.0 0.0 0.1 0.1 0.1 0.0 0.0 12.9 0.0 0.0 0.0 0.0 0.8 0.2 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 40.2 2.0 0.1 0.1 0.1 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.1 6.5 0.3 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.4 0.4 0.0 7.9 0.2 3.5 0.2 0.1 0.1 0.1 0.1 0.1 0.0 0.5 0.1 0.3 0.0 0.1 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.1 0.0 0.1 0.0 0.0 1.9 1.7 1.1 2.3 2.5 2.8 9.8 12.2 8.2 5.9 1.9 3.0 0.2 0.0 3.3 0.7 0.5 0.0 0.7 0.0 0.0 0.9 1.3 0.0 169.0 0.0 3.7 0.0 2.1 2.0 0.2 0.0 0.0 0.0 8.1 44.8 7.1 1.7 0.0 0.0 0.9 0.2 0.5 6.7 0.0 2.2 1.3 1.6 0.7 0.1 0.4 0.0 0.6 0.0 0.0 0.0 0.0 7.2 0.6 0.8 0.0 0.0 0.2 0.8 0.0 0.0 0.2 0.1 0.0 0.0 0.3 0.8 0.0 0.2 8.7 1.3 0.0 4.9 2.7 1.0 0.7 0.0 0.0 0.3 0.8 0.7 0.0 0.8 MYLK4 SgK085 ENSG00000145949 "Myosin light chain kinase family member 4" Q86YV6 6 2663629-2750922 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 17 "skeletal muscle: 30.1;tongue: 72.1" "Cell type enhanced" "Detected in some" "Excitatory neurons: 7.8;Inhibitory neurons: 7.2;Microglial cells: 4.7;Oligodendrocyte precursor cells: 8.0;Proximal tubular cells: 4.5" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 7 "HEL: 7.2" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA015860 Uncertain Approved "Nucleoli,Golgi apparatus,Vesicles" NA NA "Cluster 13: Striated muscle - Muscle contraction" "Cluster 36: HEL - Hemostasis" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Golgi apparatus" "Nucleoli, Vesicles" "HPA015860: AB_2147922" "unprognostic (1.75e-1)" "unprognostic (2.04e-1)" "unprognostic (1.87e-1)" "unprognostic (5.22e-3)" "unprognostic (1.85e-1)" "unprognostic (2.99e-2)" "unprognostic (7.48e-2)" "unprognostic (2.80e-1)" "unprognostic (5.32e-2)" "unprognostic (2.25e-1)" "unprognostic (2.02e-2)" "unprognostic (2.91e-1)" "unprognostic (2.74e-3)" "unprognostic (1.43e-1)" "unprognostic (2.65e-1)" "unprognostic (1.19e-2)" "unprognostic (4.63e-2)" 1.2 0.5 0.6 0.3 0.6 0.8 1.0 0.6 0.9 0.6 0.7 0.4 0.3 0.6 0.7 1.3 0.5 0.4 1.4 0.7 0.7 3.0 0.5 1.2 0.4 0.4 0.5 0.4 0.9 0.9 1.3 0.6 0.4 0.7 0.3 0.8 2.4 0.6 30.1 1.4 0.6 0.3 0.4 0.6 0.6 0.4 0.6 0.3 0.8 72.1 0.7 0.6 0.8 0.6 0.1 0.1 0.3 0.6 0.5 0.6 0.3 0.4 0.8 0.2 0.2 0.3 0.6 0.6 0.9 0.4 0.1 1.0 0.1 0.2 0.3 0.1 0.3 7.2 0.4 0.0 0.2 0.2 0.3 0.8 0.3 0.0 0.6 0.3 0.3 0.1 0.0 0.0 0.1 0.3 0.0 0.8 0.1 0.2 0.0 0.5 0.0 0.0 0.4 0.1 0.5 0.3 0.1 0.1 0.3 0.5 0.2 0.5 0.4 0.2 0.0 0.1 0.2 0.2 0.1 0.0 0.1 0.2 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.6 0.6 0.9 0.7 0.7 0.4 0.5 0.4 0.4 0.6 0.6 0.5 3.2 1.1 1.6 0.5 0.1 0.1 0.5 0.6 1.0 0.6 0.3 1.9 1.5 1.0 0.0 0.0 0.3 0.1 0.2 0.0 0.3 0.4 0.1 0.7 0.6 1.2 0.0 7.8 0.2 0.0 0.5 0.0 0.2 0.0 0.6 1.1 0.2 0.3 1.7 7.2 0.0 0.0 0.8 1.2 0.2 0.3 0.4 0.0 4.7 1.1 0.3 0.0 8.0 2.9 0.0 0.0 1.5 0.0 0.2 0.1 4.5 0.3 0.3 0.0 0.8 0.3 0.0 0.3 0.3 0.9 0.3 0.2 0.4 0.3 0.2 MYO3A DFNB30 ENSG00000095777 "Myosin IIIA" Q8NEV4 10 25934229-26212532 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Hearing, Sensory transduction, Vision" "Actin-binding, Kinase, Motor protein, Myosin, Serine/threonine-protein kinase, Transferase" "Deafness, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "retina: 15.5;testis: 5.2" "Cell type enhanced" "Detected in some" "Early spermatids: 156.6;Late spermatids: 58.2;Muller glia cells: 74.8;Spermatocytes: 31.7" "Cancer enhanced" "Detected in many" "cervical cancer: 1.7" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 1.3;CAPAN-2: 1.2;HEK 293: 1.5;SCLC-21H: 1.4;U-2 OS: 2.4;U-698: 6.3" "Not detected" "Not detected" "HPA051893, HPA075413" Enhanced Supported "Plasma membrane,Actin filaments,Cytoplasmic bodies" No No "Cluster 77: Retina - Visual perception" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 5: Muller glia cells - Visual perception" "Actin filaments, Cytoplasmic bodies" "Plasma membrane" "HPA051893: , HPA075413: " "unprognostic (5.00e-3)" "unprognostic (3.36e-2)" "unprognostic (1.53e-1)" "unprognostic (3.20e-3)" "unprognostic (2.96e-1)" "unprognostic (4.37e-2)" "unprognostic (5.29e-2)" "unprognostic (2.74e-1)" "unprognostic (4.31e-2)" "unprognostic (1.03e-1)" "unprognostic (5.66e-3)" "unprognostic (7.96e-3)" "unprognostic (6.34e-2)" "unprognostic (1.46e-2)" "unprognostic (6.62e-2)" "unprognostic (9.69e-2)" 0.1 0.1 0.4 0.0 1.8 0.1 0.1 0.0 0.8 0.1 0.2 0.1 0.0 0.0 0.0 0.3 0.3 0.0 0.0 0.1 0.6 0.3 0.0 0.1 0.0 0.6 0.5 0.0 0.7 0.0 0.5 0.0 0.5 0.1 0.3 15.5 0.0 0.1 0.0 0.7 0.1 0.0 0.2 0.0 0.2 5.2 0.3 0.2 0.2 0.1 0.2 0.0 0.3 0.3 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.9 0.8 0.0 0.0 0.7 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 6.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 1.8 0.0 0.8 0.1 0.6 0.6 0.5 0.5 0.2 0.3 0.3 0.2 0.0 0.5 2.0 0.1 1.8 0.3 0.0 0.0 0.9 0.6 0.3 0.6 0.0 2.5 0.0 0.0 0.0 0.0 0.2 1.9 0.8 156.6 0.6 0.1 0.3 1.8 0.0 2.2 0.0 0.4 0.6 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 5.9 0.4 0.0 0.0 0.0 58.2 1.2 0.1 0.0 1.9 0.0 74.8 0.0 1.0 0.4 0.2 0.0 1.2 0.0 0.3 0.0 1.0 0.0 3.9 0.0 0.0 2.4 31.7 14.2 2.4 1.0 0.0 0.0 0.0 0.4 0.3 MYO3B ENSG00000071909 "Myosin IIIB" Q8WXR4 2 170178145-170655171 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hearing, Sensory transduction, Vision" "Actin-binding, Kinase, Motor protein, Myosin, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "epididymis: 14.1;kidney: 5.3;parathyroid gland: 8.8;retina: 5.8" "Cell type enhanced" "Detected in some" "Cone photoreceptor cells: 85.5;Early spermatids: 34.2;Inhibitory neurons: 18.3;Late spermatids: 29.6;Rod photoreceptor cells: 51.0" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 9 "HDLM-2: 11.2;HEL: 8.8;RT4: 11.7" "Region enriched" "Detected in some" 5 "basal ganglia: 5.2" "Not detected" "Not detected" HPA045483 Approved NA NA "Cluster 68: Epididymis - Unknown function" "Cluster 36: HEL - Hemostasis" "Cluster 9: Photoreceptor cells - Phototransduction" "HPA045483: AB_2679344" "unprognostic (1.65e-1)" "unprognostic (7.87e-2)" "unprognostic (1.96e-2)" "unprognostic (1.43e-2)" "unprognostic (1.67e-1)" "unprognostic (7.15e-3)" "unprognostic (5.07e-2)" "unprognostic (2.61e-2)" "unprognostic (5.84e-3)" "unprognostic (2.12e-1)" "unprognostic (7.99e-3)" "unprognostic (2.59e-1)" "unprognostic (4.25e-5)" "unprognostic (2.34e-1)" "unprognostic (8.12e-3)" "unprognostic (1.18e-1)" "unprognostic (1.07e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.6 0.0 0.0 0.0 0.1 14.1 0.4 0.6 0.1 0.0 0.0 0.3 5.3 0.0 0.0 0.0 0.0 0.0 0.0 0.5 8.8 0.3 0.0 0.0 0.0 0.0 5.8 0.1 1.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.9 0.0 0.4 1.3 0.0 0.1 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.3 0.0 0.0 11.2 0.0 8.8 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.8 0.1 0.0 0.0 0.0 0.0 1.1 11.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 1.3 0.3 0.6 0.5 0.3 0.0 3.1 0.2 0.3 0.7 0.0 0.5 3.7 85.5 0.0 0.6 0.1 13.7 0.3 34.2 5.3 0.4 0.3 1.8 0.0 1.8 0.0 0.0 0.8 0.0 1.7 0.0 0.1 0.0 0.2 0.0 0.0 18.3 0.6 0.0 0.3 1.1 29.6 0.3 0.2 0.0 1.9 0.0 3.0 0.0 5.5 2.9 0.1 0.0 0.4 0.0 0.2 0.0 0.2 0.2 51.0 0.0 1.7 0.5 1.5 0.8 0.3 0.4 0.1 0.3 0.3 0.0 0.1 NAA10 "ARD1, ARD1A, DXS707, TE2" ENSG00000102030 "N-alpha-acetyltransferase 10, NatA catalytic subunit" P41227 X 153929225-153935080 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Acyltransferase, Transferase" "Disease variant, Microphthalmia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB006269, HPA030711" Supported Supported Nucleoli,Cytosol No No "Cluster 12: Non-specific - Basic cellular processes" "Cluster 59: Non-specific - Translation" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 39: Non-specific - Basic cellular processes" Cytosol Nucleoli "CAB006269: AB_425759, HPA030711: AB_2673579" "unprognostic (7.57e-2)" "unprognostic (1.40e-2)" "unprognostic (1.81e-2)" "unprognostic (1.19e-1)" "unprognostic (1.02e-2)" "unprognostic (1.94e-2)" "unprognostic (4.52e-3)" "unprognostic (1.22e-1)" "unprognostic (1.68e-1)" "unprognostic (1.04e-1)" "unprognostic (9.01e-2)" "unprognostic (9.63e-2)" "prognostic unfavorable (3.29e-8)" "unprognostic (1.28e-1)" "unprognostic (1.40e-1)" "unprognostic (1.29e-2)" "unprognostic (7.48e-3)" 38.4 39.5 19.6 17.2 20.1 13.2 34.6 20.4 27.2 26.5 19.2 34.1 15.3 32.3 15.1 40.5 24.4 10.3 56.3 20.0 21.8 34.1 35.9 26.0 19.7 20.8 20.3 23.8 45.8 13.7 22.5 12.5 20.8 27.6 10.2 7.3 25.3 12.2 98.4 30.9 24.9 18.1 20.4 28.8 35.9 9.1 21.2 10.2 21.7 24.9 15.3 35.9 26.8 20.4 133.4 136.0 25.8 83.0 36.7 36.9 71.2 46.3 28.6 63.8 57.0 88.5 41.0 102.0 147.6 38.7 79.2 63.0 57.9 56.8 23.9 42.1 255.2 36.8 85.8 91.3 49.1 71.4 76.8 28.8 62.2 57.9 59.1 30.7 72.0 39.2 75.1 41.5 41.6 172.8 115.0 106.4 42.9 124.4 189.0 90.1 65.7 111.5 47.7 59.7 54.0 65.7 18.7 71.0 113.7 23.9 38.4 58.8 41.1 25.6 88.5 89.5 142.0 86.3 107.2 196.0 34.7 91.0 75.5 35.3 53.1 81.3 60.0 65.3 78.1 75.2 63.4 65.6 69.4 77.7 37.4 56.7 49.8 64.7 76.0 75.9 102.9 70.6 19.6 20.1 20.4 27.2 20.0 21.8 20.8 20.3 20.8 20.4 21.2 20.4 126.9 9.6 30.2 27.1 76.0 70.1 66.1 90.6 68.3 29.5 82.6 113.8 45.1 47.1 52.8 38.6 12.5 125.9 77.0 94.5 95.9 121.1 2.9 46.0 60.7 98.7 58.1 78.9 18.6 149.9 179.0 57.3 76.5 43.4 67.9 64.2 77.8 78.7 123.1 37.0 14.6 92.2 54.9 66.5 96.0 12.5 46.6 66.4 119.2 9.4 84.8 37.9 85.5 14.1 19.1 144.6 75.2 46.6 104.3 136.9 91.5 197.0 40.2 30.4 65.7 56.6 98.3 7.6 33.1 120.7 90.5 108.8 74.8 97.7 110.3 85.9 NAA11 "ARD1B, ARD2, hARD2" ENSG00000156269 "N-alpha-acetyltransferase 11, NatA catalytic subunit" Q9BSU3 4 79225694-79326061 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 9 "brain: 2.6;placenta: 4.2;testis: 6.2" "Group enriched" "Detected in some" 12 "Cytotrophoblasts: 19.4;Early spermatids: 30.6;Extravillous trophoblasts: 16.4;Late spermatids: 23.9;Spermatocytes: 25.1;Spermatogonia: 15.9;Syncytiotrophoblasts: 13.3" "Cancer enriched" "Detected in some" 4 "testis cancer: 2.1" "Region enriched" "Detected in single" 5 "cerebellum: 2.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 6 "GAMG: 19.3;K-562: 12.3;U-266/70: 32.9;U-266/84: 11.3" "Not detected" "Not detected" HPA035922 Approved Supported "Nucleoplasm,Golgi apparatus,Centrosome,Cytosol" NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 29: U-266 - Adaptive immune response" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm "Golgi apparatus, Centrosome, Cytosol" "HPA035922: AB_10673490" "unprognostic (7.37e-2)" "unprognostic (7.58e-2)" "unprognostic (1.36e-1)" "unprognostic (1.20e-1)" "unprognostic (4.67e-1)" 0.0 0.0 0.2 0.0 0.2 0.0 0.0 2.6 0.1 0.0 0.2 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.5 0.4 0.1 0.0 0.0 0.0 4.2 0.3 0.1 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.1 0.3 0.0 0.0 6.2 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.1 0.0 19.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 12.3 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.2 3.3 0.0 0.3 0.3 0.0 0.2 0.0 0.2 0.1 0.0 0.0 0.2 0.0 32.9 11.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 2.6 0.1 0.1 0.2 0.5 0.4 0.3 0.3 0.5 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 19.4 0.0 0.0 0.0 0.0 30.6 0.0 0.0 0.1 0.0 0.0 0.0 0.0 16.4 0.3 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 0.0 0.0 23.9 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 25.1 15.9 0.0 0.0 13.3 0.0 0.0 0.0 0.0 NAA20 "dJ1002M8.1, NAT3, NAT5" ENSG00000173418 "N-alpha-acetyltransferase 20, NatB catalytic subunit" P61599 20 20017310-20033655 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 399.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA063344 Supported Cytosol NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 8: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Cytosol "HPA063344: AB_2684991" "unprognostic (2.94e-2)" "unprognostic (1.14e-1)" "unprognostic (7.14e-2)" "unprognostic (2.59e-1)" "unprognostic (1.89e-1)" "prognostic unfavorable (1.96e-4)" "unprognostic (2.00e-2)" "unprognostic (1.11e-2)" "unprognostic (2.40e-1)" "unprognostic (6.18e-2)" "unprognostic (9.30e-2)" "unprognostic (3.85e-1)" "unprognostic (2.93e-1)" "unprognostic (1.72e-1)" "unprognostic (2.13e-1)" "unprognostic (2.28e-1)" "unprognostic (1.32e-1)" 50.4 53.3 38.9 34.8 40.6 46.5 65.3 41.6 51.6 40.8 54.0 41.9 27.9 41.7 54.2 113.5 41.6 32.6 61.7 40.2 42.9 85.2 82.5 40.2 37.3 40.9 41.3 33.0 62.7 103.9 26.7 53.0 41.9 43.5 42.8 49.6 47.1 46.9 84.9 38.2 33.9 46.2 42.3 31.8 42.1 66.6 41.5 37.1 59.7 73.6 51.0 51.3 44.1 44.5 212.7 139.9 50.1 69.4 95.0 116.6 67.7 149.2 100.3 132.1 123.8 67.0 137.7 108.4 80.6 113.6 125.5 156.3 85.8 233.2 153.2 51.4 75.7 79.4 49.6 132.6 141.2 102.2 65.9 122.4 182.1 132.8 153.9 93.2 139.7 80.4 126.7 115.7 157.6 177.2 128.6 149.9 37.9 181.5 180.7 69.8 191.9 148.3 190.0 70.4 84.1 62.2 81.9 254.1 170.7 42.5 145.4 171.1 113.7 106.6 75.4 137.8 153.8 130.0 171.9 116.9 66.5 76.2 76.7 39.7 86.2 70.1 55.5 97.5 83.6 63.3 65.9 65.4 92.9 56.6 63.5 75.0 12.5 70.3 81.8 77.7 75.6 100.6 38.9 40.6 41.6 51.6 40.2 42.9 40.9 41.3 41.9 42.3 41.5 44.5 60.5 67.3 42.2 17.0 44.9 108.7 113.6 312.4 45.5 52.9 62.9 75.2 73.1 77.2 147.8 104.8 25.0 111.8 51.4 32.6 230.9 194.0 399.9 99.5 87.6 77.4 41.3 28.8 18.0 169.0 102.2 66.4 31.1 75.8 51.3 46.5 50.3 72.9 255.9 69.0 22.7 43.8 164.8 66.8 56.1 60.5 69.9 68.6 71.2 31.9 100.1 91.5 58.7 16.1 25.2 198.0 37.1 74.9 44.2 184.5 45.7 242.6 199.9 60.7 39.5 75.8 90.8 354.2 58.3 122.5 118.8 85.5 40.8 99.5 54.2 141.7 NAA30 "C14orf35, FLJ35355, MAK3, Mak3p, NAT12" ENSG00000139977 "N-alpha-acetyltransferase 30, NatC catalytic subunit" Q147X3 14 57390544-57415906 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 107.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA057824 Uncertain Supported Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 66: Spermatocytes - Spermatogenesis" Cytosol "HPA057824: AB_2683539" "unprognostic (5.13e-2)" "unprognostic (7.59e-2)" "unprognostic (1.09e-1)" "unprognostic (1.52e-2)" "unprognostic (5.22e-2)" "unprognostic (6.31e-2)" "unprognostic (1.84e-2)" "unprognostic (5.44e-2)" "unprognostic (2.59e-1)" "unprognostic (1.12e-1)" "unprognostic (1.67e-1)" "unprognostic (5.21e-2)" "prognostic favorable (1.25e-8)" "unprognostic (1.77e-1)" "unprognostic (1.67e-1)" "unprognostic (5.75e-3)" "unprognostic (1.63e-1)" 9.6 7.7 9.7 7.2 11.3 15.0 9.6 10.6 11.8 7.8 6.5 8.4 9.9 9.1 7.1 11.3 7.4 7.1 14.2 11.6 11.6 12.4 16.7 6.4 9.0 8.6 9.3 14.9 9.0 12.5 5.7 13.4 9.2 10.1 7.9 12.0 8.0 10.1 31.8 8.3 8.7 10.1 9.3 8.3 7.0 18.5 12.4 9.0 10.6 27.3 9.1 8.2 6.0 9.4 19.4 18.2 10.2 16.7 16.8 21.9 17.1 22.1 21.3 16.5 15.0 16.5 13.9 14.1 19.0 18.4 12.5 20.1 18.5 14.3 27.4 24.7 9.4 11.4 10.1 14.5 17.5 23.1 12.8 15.0 20.7 15.0 24.9 18.4 25.8 17.3 11.3 13.6 22.1 22.1 19.5 13.4 11.0 17.8 20.0 15.3 29.4 11.0 16.9 17.4 21.8 11.5 18.7 18.3 23.0 18.2 23.6 11.9 22.7 25.7 27.0 14.2 14.3 10.1 13.2 16.9 17.1 11.5 18.7 0.8 0.4 0.2 1.2 0.9 1.2 1.0 1.1 1.8 0.3 1.1 1.2 1.2 0.2 2.4 2.8 0.6 1.7 0.4 9.7 11.3 10.6 11.8 11.6 11.6 8.6 9.3 9.2 9.3 12.4 9.4 11.8 9.6 6.3 10.1 16.7 41.0 11.8 8.6 25.0 13.5 16.5 10.9 34.9 17.2 8.0 3.7 18.8 18.3 20.1 11.6 9.8 12.5 107.1 9.0 13.1 17.0 21.0 9.0 20.3 11.6 15.6 13.1 12.8 10.8 7.0 14.9 11.0 25.5 9.9 10.1 20.3 13.7 6.1 13.2 12.1 37.6 13.7 8.2 23.2 10.3 9.9 13.3 8.2 16.6 18.9 14.5 13.8 13.5 18.1 18.9 13.6 17.9 9.5 15.3 19.7 13.3 15.4 69.2 20.5 25.5 41.2 22.2 17.0 13.3 12.6 16.7 NAA40 "FLJ13848, NAT11" ENSG00000110583 "N-alpha-acetyltransferase 40, NatD catalytic subunit" Q86UY6 11 63938959-63957319 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Horizontal cells: 102.6;Late spermatids: 130.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037816, HPA056142" Uncertain Supported "Nucleoplasm,Centriolar satellite,Cytosol" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 62: Horizontal cells - Visual perception" Nucleoplasm "Centriolar satellite, Cytosol" "HPA037816: AB_10672289, HPA056142: " "unprognostic (3.52e-1)" "unprognostic (4.12e-1)" "unprognostic (1.40e-1)" "unprognostic (6.88e-3)" "unprognostic (1.50e-1)" "unprognostic (2.11e-1)" "prognostic unfavorable (1.43e-7)" "unprognostic (1.45e-1)" "unprognostic (1.13e-2)" "unprognostic (1.58e-1)" "unprognostic (7.01e-3)" "unprognostic (6.29e-3)" "unprognostic (3.42e-2)" "unprognostic (6.43e-3)" "unprognostic (2.49e-1)" "unprognostic (1.55e-1)" "unprognostic (5.25e-2)" 3.3 8.9 5.1 3.9 5.1 2.5 4.4 4.5 5.7 4.0 5.7 5.2 5.7 3.0 3.3 6.7 6.8 3.6 9.5 5.3 4.9 9.1 3.8 3.6 7.5 5.6 5.3 2.7 6.5 15.1 10.4 6.7 5.2 4.2 4.7 7.2 6.6 4.0 4.7 2.7 5.7 3.1 5.0 8.8 4.8 15.3 5.2 10.0 6.1 8.5 7.3 4.2 3.6 5.0 15.5 17.3 21.7 11.8 6.0 5.9 13.8 11.3 12.0 27.3 19.1 14.8 19.3 9.5 13.6 10.2 18.9 13.7 18.3 8.2 20.1 12.5 11.2 13.0 11.1 16.9 7.9 20.9 10.8 6.0 7.4 17.0 4.6 10.6 18.0 16.1 22.4 6.9 12.9 11.8 22.3 16.3 20.2 14.3 11.8 21.9 19.5 12.1 18.5 11.8 28.7 15.1 17.7 15.2 9.2 15.8 25.1 9.2 11.6 15.1 18.3 8.9 9.3 8.3 5.6 16.5 9.2 8.9 11.9 2.3 0.5 2.7 6.9 0.4 2.4 2.7 1.8 3.3 2.7 2.4 1.1 2.6 0.1 5.2 0.2 3.5 0.5 2.3 5.1 5.1 4.5 5.7 5.3 4.9 5.6 5.3 5.2 5.0 5.2 5.0 4.3 3.2 4.8 12.1 8.1 2.8 2.0 4.5 10.8 30.9 11.5 7.0 14.8 5.7 9.4 18.4 33.3 9.6 12.1 13.6 0.0 5.7 46.3 20.0 7.4 7.6 17.5 7.4 14.3 5.4 12.8 4.8 6.1 8.5 1.3 14.3 9.7 5.2 9.5 102.6 15.6 6.1 10.2 10.3 5.3 130.5 4.7 7.3 1.8 15.0 4.4 8.6 17.5 11.6 10.1 5.9 3.5 7.2 12.2 2.1 10.6 4.1 22.5 23.9 0.0 4.3 4.4 27.4 16.5 6.5 2.8 4.1 8.9 10.4 7.3 1.8 NAA50 "FLJ13194, MAK3, NAT13, NAT5, San" ENSG00000121579 "N-alpha-acetyltransferase 50, NatE catalytic subunit" Q9GZZ1 3 113716458-113746300 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 320.7" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA074489 Approved Supported Nucleoli NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 59: Non-specific - Translation" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 22: Epithelial cell types - Mixed function" Nucleoli "HPA074489: " "unprognostic (9.74e-2)" "unprognostic (1.49e-1)" "unprognostic (3.19e-2)" "prognostic unfavorable (2.32e-4)" "unprognostic (4.75e-2)" "unprognostic (1.51e-1)" "prognostic unfavorable (1.51e-5)" "unprognostic (1.62e-3)" "unprognostic (6.82e-2)" "unprognostic (3.43e-1)" "prognostic unfavorable (7.92e-5)" "unprognostic (2.97e-3)" "unprognostic (1.09e-1)" "unprognostic (2.25e-2)" "unprognostic (9.59e-2)" "unprognostic (7.13e-3)" "unprognostic (2.43e-1)" 88.2 64.2 21.8 72.0 24.7 87.3 58.4 25.2 29.4 49.2 27.2 62.5 48.9 50.1 31.4 93.4 38.5 50.6 50.9 23.7 24.4 64.4 90.3 43.5 84.9 23.6 25.0 51.7 58.7 59.8 23.1 45.0 25.3 52.8 54.1 31.5 69.7 42.1 320.7 53.4 47.5 51.2 25.2 52.6 65.6 53.2 26.6 56.8 58.5 154.4 90.7 87.6 46.3 28.2 589.6 250.7 135.2 158.5 179.4 144.6 281.4 308.5 172.4 186.0 212.4 362.3 205.7 403.4 185.8 164.6 146.9 236.5 238.0 211.1 338.6 85.2 121.5 435.7 182.7 220.3 164.4 459.1 135.7 124.0 163.0 208.8 298.3 122.1 168.7 167.3 279.3 157.8 194.3 277.0 306.2 99.3 303.4 228.3 365.3 309.5 207.2 318.9 141.7 439.9 207.4 119.6 223.6 164.1 229.0 116.5 228.1 150.4 156.9 255.1 253.9 109.1 235.7 174.1 314.2 736.0 200.2 253.2 160.6 17.7 40.8 22.5 45.5 40.5 40.6 55.2 33.7 43.1 44.4 37.1 29.4 39.1 51.8 31.8 38.1 25.6 39.9 52.5 21.8 24.7 25.2 29.4 23.7 24.4 23.6 25.0 25.3 25.2 26.6 28.2 33.9 48.1 39.9 24.8 75.7 168.4 86.6 42.6 76.2 24.8 52.3 31.6 47.5 25.8 45.8 36.8 8.4 46.0 78.2 51.3 78.2 52.9 68.0 44.4 53.1 45.7 19.9 79.5 41.5 55.1 94.6 55.2 35.7 94.3 47.5 45.5 29.3 66.1 61.9 40.4 39.0 31.5 42.7 55.3 148.8 50.7 30.7 60.1 62.2 20.6 49.9 29.7 29.9 33.2 28.4 65.2 36.8 31.2 74.9 142.0 31.4 71.0 30.0 18.4 19.7 53.1 64.1 53.5 60.8 99.8 177.9 62.5 74.7 37.7 49.3 193.3 NAA60 "FLJ14154, NAT15" ENSG00000122390 "N-alpha-acetyltransferase 60, NatF catalytic subunit" Q9H7X0 16 3443649-3486953 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Chromosome partition" "Acyltransferase, Chromatin regulator, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040916 Approved Uncertain "Actin filaments,Cytosol" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 18: Non-specific - Mitochondria" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 45: Enterocytes - Digestion" "Actin filaments, Cytosol" "HPA040916: AB_10794428" "unprognostic (8.59e-2)" "unprognostic (2.16e-3)" "unprognostic (3.39e-1)" "prognostic favorable (3.14e-4)" "unprognostic (1.81e-1)" "unprognostic (5.90e-2)" "unprognostic (2.88e-2)" "unprognostic (1.53e-2)" "unprognostic (5.23e-2)" "unprognostic (5.12e-2)" "prognostic favorable (4.30e-4)" "unprognostic (9.54e-2)" "unprognostic (1.64e-1)" "unprognostic (1.60e-2)" "unprognostic (8.96e-2)" "unprognostic (3.59e-1)" "unprognostic (6.74e-3)" 25.5 45.4 31.5 16.9 30.0 20.1 25.1 37.5 35.9 28.4 22.7 40.4 40.5 31.6 18.7 31.0 28.2 20.3 48.9 31.9 27.5 52.4 67.5 32.0 20.2 30.8 30.5 26.8 47.9 49.1 41.6 19.5 29.3 35.2 22.6 16.3 26.0 23.9 42.9 24.2 39.3 19.1 28.8 42.9 58.9 32.7 31.2 19.5 32.0 21.2 16.7 28.4 23.2 30.3 16.8 61.9 40.1 44.1 26.5 19.4 39.1 26.9 25.0 29.3 26.6 43.9 30.5 31.7 30.0 29.6 21.0 37.4 40.1 31.2 29.4 49.7 27.8 35.4 25.7 53.0 32.9 53.1 45.6 24.4 27.9 20.4 38.9 29.2 45.1 29.4 44.8 41.4 19.4 73.6 33.4 36.3 50.1 35.8 18.1 42.3 30.8 47.5 27.7 29.7 21.6 42.5 45.8 48.3 24.6 38.5 40.2 34.7 30.8 36.0 27.7 12.8 26.7 35.2 33.6 30.5 12.1 29.0 29.2 33.3 18.6 53.8 17.7 20.6 19.2 11.6 15.8 17.7 18.1 11.0 12.3 16.4 20.0 18.4 23.6 11.6 20.1 19.5 31.5 30.0 37.5 35.9 31.9 27.5 30.8 30.5 29.3 28.8 31.2 30.3 26.3 9.6 16.0 24.8 17.7 0.1 13.4 0.1 17.6 21.2 24.5 16.4 15.5 38.6 5.6 12.9 6.2 28.3 22.7 66.7 43.0 30.1 55.7 33.3 25.7 21.0 27.0 18.7 22.2 41.7 40.0 18.0 37.2 30.9 30.4 18.4 26.7 53.5 32.1 11.8 26.5 43.1 0.0 34.8 0.3 54.4 11.5 23.6 0.0 25.3 27.0 29.3 26.8 22.1 34.8 37.0 54.3 15.8 15.4 20.2 84.2 49.0 3.7 15.3 26.3 16.8 17.7 19.6 24.5 16.5 0.3 33.0 22.9 21.1 35.3 23.5 NADK FLJ13052 ENSG00000008130 "NAD kinase" O95544 1 1751232-1780457 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 506.2" "Group enriched" "Detected in all" 7 "granulocytes: 506.2;monocytes: 162.6" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA048909, HPA053368" Uncertain Approved Nucleoplasm,Vesicles NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 18: Non-specific - Mitochondria" "Cluster 25: RPMI-8226 - Immune response" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Nucleoplasm Vesicles "HPA048909: AB_2680553, HPA053368: AB_2682130" "unprognostic (1.29e-1)" "unprognostic (4.29e-1)" "unprognostic (7.07e-2)" "unprognostic (6.82e-2)" "unprognostic (1.98e-1)" "unprognostic (1.58e-2)" "unprognostic (3.32e-1)" "unprognostic (9.03e-2)" "unprognostic (7.81e-2)" "unprognostic (1.11e-1)" "unprognostic (1.49e-1)" "unprognostic (1.68e-1)" "unprognostic (4.54e-3)" "unprognostic (1.40e-1)" "unprognostic (5.36e-2)" "unprognostic (1.50e-2)" "unprognostic (1.16e-1)" 53.6 81.8 24.8 37.5 26.6 100.7 44.7 22.1 29.0 28.6 27.8 45.1 38.0 30.9 13.3 29.9 36.1 23.3 28.7 24.1 24.3 30.2 134.0 40.3 41.2 25.4 24.6 37.2 38.9 17.2 26.4 26.0 25.0 32.9 25.4 10.9 40.2 17.4 19.6 28.3 43.3 19.8 24.5 93.1 43.2 27.5 26.5 16.4 31.7 19.2 26.6 32.3 27.1 23.8 41.6 39.3 34.4 50.7 47.8 34.5 44.2 40.9 35.5 45.6 40.3 42.1 74.2 54.5 30.4 30.5 14.7 34.6 37.3 32.5 20.3 53.5 59.1 44.7 65.0 73.6 46.2 63.4 72.1 40.6 28.9 28.4 40.3 24.8 44.9 42.6 55.9 75.8 34.4 47.4 48.1 54.8 23.5 69.4 43.8 60.4 29.4 113.1 39.7 33.9 46.2 35.2 45.8 99.2 43.7 20.3 34.2 43.6 43.8 33.1 23.7 34.6 37.5 67.1 32.7 121.8 32.7 69.3 17.6 84.2 141.3 329.7 7.4 158.6 8.8 10.8 4.3 5.9 45.9 12.1 2.8 4.1 506.2 3.8 162.6 37.9 7.0 82.9 24.8 26.6 22.1 29.0 24.1 24.3 25.4 24.6 25.0 24.5 26.5 23.8 29.0 12.8 30.7 14.4 27.2 9.8 15.7 11.2 13.6 7.9 21.4 17.9 6.8 25.8 21.6 14.7 16.7 24.5 46.8 57.8 15.6 19.1 14.9 18.7 22.2 20.8 22.8 15.8 10.2 29.4 26.3 18.7 52.0 22.8 2.5 21.2 22.5 94.3 36.6 6.7 10.4 38.7 16.2 58.4 13.7 26.7 37.6 45.0 8.8 9.4 67.3 5.7 27.8 10.6 11.1 28.7 34.6 34.6 26.0 34.7 28.6 24.3 13.5 17.7 13.1 12.6 18.2 12.4 22.4 19.5 12.8 42.8 15.4 44.2 31.0 27.5 NADK2 "C5orf33, FLJ30596, MNADK, NADKD1" ENSG00000152620 "NAD kinase 2, mitochondrial" Q4G0N4 5 36192589-36242279 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 11 "liver: 328.0" "Group enriched" "Detected in many" 5 "Astrocytes: 105.4;Early spermatids: 324.5;Hepatocytes: 211.9;Late spermatids: 154.9" "Cancer enhanced" "Detected in all" "liver cancer: 36.9" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038366, HPA038367, HPA061492" Enhanced Supported Mitochondria NA NA 30000 "Cluster 24: B-cells - Unknown function" "Cluster 62: Liver - Hemostasis" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 23: Spermatids - Flagellum & Golgi organization" Mitochondria "HPA038366: AB_2675977, HPA038367: AB_10672743, HPA061492: AB_2684538" "unprognostic (1.15e-2)" "unprognostic (2.63e-2)" "unprognostic (3.01e-2)" "unprognostic (3.10e-3)" "unprognostic (1.64e-1)" "unprognostic (1.97e-2)" "unprognostic (4.06e-3)" "unprognostic (8.84e-2)" "unprognostic (3.32e-2)" "unprognostic (1.93e-3)" "unprognostic (1.09e-1)" "unprognostic (1.76e-1)" "unprognostic (9.73e-2)" "unprognostic (1.93e-1)" "unprognostic (1.58e-1)" "unprognostic (2.54e-2)" "unprognostic (1.75e-2)" 13.6 20.1 26.6 9.3 23.3 10.6 15.4 21.9 24.2 13.7 14.0 13.9 16.6 13.3 7.9 10.4 12.7 11.9 20.2 22.2 27.1 23.2 328.0 8.4 9.5 25.4 27.4 19.6 26.9 10.7 5.5 16.9 25.3 19.0 13.8 11.2 13.0 16.2 29.4 6.6 12.9 14.2 31.0 8.6 17.1 18.2 25.3 10.3 17.3 29.8 11.4 27.9 8.8 30.3 21.5 14.6 22.4 23.5 32.2 27.2 27.5 19.5 13.2 17.5 13.2 41.4 27.4 74.3 14.0 23.3 23.0 14.9 20.0 14.3 24.2 21.2 16.3 22.0 43.1 23.9 22.7 46.5 8.0 28.9 22.5 21.6 29.9 22.4 18.4 30.2 52.0 27.8 18.0 9.0 42.3 18.2 10.7 18.1 19.2 40.2 51.6 15.8 24.2 18.2 8.7 20.1 102.0 32.4 10.5 16.7 22.9 39.8 15.1 34.1 18.2 27.0 23.9 23.7 30.3 23.2 14.5 57.2 14.2 8.2 1.2 1.1 1.3 1.4 1.8 1.3 1.9 1.5 2.3 5.3 1.6 1.4 0.1 6.7 3.3 1.2 2.1 1.4 26.6 23.3 21.9 24.2 22.2 27.1 25.4 27.4 25.3 31.0 25.3 30.3 9.6 3.2 6.9 105.4 7.5 6.8 6.8 5.4 6.2 5.7 18.3 11.2 29.3 25.8 7.1 5.5 8.4 9.2 9.6 7.4 25.4 5.0 324.5 6.1 9.4 6.8 7.2 13.7 23.8 9.5 8.9 12.5 5.6 7.1 1.3 10.0 12.1 211.9 8.9 3.3 18.3 11.7 4.1 10.4 9.6 154.9 19.9 6.4 14.2 11.2 3.7 16.9 5.2 21.1 23.6 6.9 8.8 23.0 14.3 14.9 6.6 23.1 7.2 5.4 0.0 11.6 13.5 35.1 11.0 7.7 5.7 7.3 6.9 26.4 11.6 12.3 NAGK GNK ENSG00000124357 "N-acetylglucosamine kinase" Q9UJ70 2 71064344-71079808 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hofbauer cells: 216.9;Syncytiotrophoblasts: 318.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Group enriched" "Detected in all" 4 "dendritic cells: 391.8;granulocytes: 288.7;monocytes: 594.1" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035206, HPA035207" Enhanced Approved Nucleoplasm,Cytosol NA NA 1000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 4: Macrophages - Innate immune response" Cytosol Nucleoplasm "HPA035206: AB_2674517, HPA035207: AB_10602031" "unprognostic (6.15e-2)" "unprognostic (4.23e-3)" "unprognostic (2.97e-2)" "prognostic unfavorable (6.88e-4)" "unprognostic (2.44e-1)" "prognostic favorable (5.87e-4)" "unprognostic (4.65e-3)" "unprognostic (2.18e-2)" "unprognostic (2.31e-1)" "unprognostic (9.99e-2)" "unprognostic (4.32e-2)" "unprognostic (1.59e-1)" "prognostic unfavorable (4.35e-4)" "unprognostic (8.60e-2)" "unprognostic (1.45e-2)" "unprognostic (5.50e-3)" "unprognostic (2.13e-2)" 41.2 36.0 47.0 61.2 48.0 21.9 35.1 49.5 52.1 57.5 47.0 37.7 21.0 33.6 40.6 156.2 29.0 44.1 31.4 46.9 52.9 35.1 42.8 39.6 79.6 50.9 50.4 31.0 42.2 80.7 42.3 44.3 53.7 30.0 34.2 16.5 75.0 37.9 26.6 63.0 33.6 50.1 48.3 88.9 33.9 50.2 49.0 60.8 27.4 32.3 98.4 71.7 59.7 52.1 55.9 39.2 22.6 25.8 114.2 67.5 98.3 119.0 65.5 95.6 86.8 54.3 29.5 30.3 29.3 107.4 113.5 25.7 22.4 43.9 62.7 44.9 16.4 17.0 12.6 37.5 91.6 10.5 37.7 60.7 49.6 101.8 16.4 68.3 107.7 31.7 8.1 34.8 143.4 52.2 28.6 40.2 28.7 53.5 38.4 22.1 64.2 15.8 65.5 91.4 25.1 13.0 35.2 62.1 45.1 50.7 30.4 13.9 66.0 99.0 37.8 36.9 44.8 23.0 24.8 18.0 69.6 31.5 54.5 86.6 594.1 245.1 36.9 526.5 39.2 102.5 44.2 37.0 391.8 103.7 36.7 30.0 288.7 65.3 378.2 318.5 54.7 466.2 47.0 48.0 49.5 52.1 46.9 52.9 50.9 50.4 53.7 48.3 49.0 52.1 22.9 38.5 34.2 15.0 48.6 26.9 28.4 60.8 19.4 46.1 27.4 27.6 18.0 17.2 56.9 38.6 22.9 146.0 67.4 13.9 41.1 66.1 151.3 22.5 26.1 31.7 23.4 12.8 11.5 45.7 144.0 35.6 15.8 24.9 51.9 31.1 30.0 12.9 216.9 47.1 15.2 20.4 28.5 121.8 67.5 33.0 30.1 106.0 39.2 26.2 118.6 45.4 17.5 17.1 24.0 59.1 32.3 37.6 51.2 15.5 23.3 64.7 35.2 55.6 19.7 31.8 37.4 68.0 25.6 39.9 41.6 318.8 29.1 32.2 16.2 34.7 NAGS "AGAS, ARGA, NAT7" ENSG00000161653 "N-acetylglutamate synthase" Q8N159 17 44004622-44009068 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Urea cycle" "Acyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 7 "intestine: 15.9;liver: 48.2" "Cell type enhanced" "Detected in many" "Hepatocytes: 21.7;Proximal enterocytes: 44.2;Proximal tubular cells: 20.7;Spermatocytes: 16.0" "Cancer enhanced" "Detected in all" "liver cancer: 12.4" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "ASC TERT1: 5.5;HHSteC: 5.2;TIME: 7.1;U-87 MG: 10.0" "Not detected" "Not detected" "Not detected" "Not detected" HPA027300 Supported Mitochondria "Intracellular and membrane" NA NA "Cluster 10: Basophils - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 66: Spermatocytes - Spermatogenesis" Mitochondria "HPA027300: AB_2672207" "unprognostic (1.51e-3)" "unprognostic (9.24e-2)" "unprognostic (1.68e-1)" "unprognostic (8.67e-2)" "unprognostic (1.44e-2)" "unprognostic (1.30e-3)" "unprognostic (2.38e-2)" "unprognostic (1.98e-1)" "unprognostic (3.14e-2)" "unprognostic (2.73e-2)" "unprognostic (2.53e-3)" "unprognostic (1.46e-1)" "unprognostic (5.19e-2)" "unprognostic (6.99e-2)" "unprognostic (1.29e-2)" "unprognostic (1.22e-1)" "unprognostic (2.27e-1)" 0.9 0.7 2.0 0.5 1.2 0.0 1.4 0.9 2.0 0.8 0.0 2.4 15.9 0.8 1.8 1.4 0.7 0.4 1.2 1.0 3.5 4.9 48.2 1.9 0.3 2.0 1.4 0.6 0.3 3.3 0.5 0.1 2.2 1.1 0.5 0.0 1.0 1.4 0.2 1.0 13.6 0.1 1.3 0.4 0.4 0.6 3.6 0.1 4.4 0.2 0.1 0.4 1.0 1.0 2.9 0.1 0.0 0.4 0.0 5.5 0.1 0.5 0.1 0.1 0.2 1.7 0.7 0.0 1.1 0.0 0.1 1.3 0.1 1.5 0.3 0.2 0.7 0.1 0.2 2.2 5.2 0.0 0.0 3.2 0.0 0.7 0.0 0.6 1.4 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.4 1.5 2.7 0.0 0.3 0.0 0.1 0.0 2.1 0.0 0.9 0.0 0.0 0.2 0.2 0.0 7.1 2.5 0.7 0.2 0.6 0.1 0.1 0.1 10.0 0.0 0.3 0.8 0.5 0.7 0.9 0.4 0.7 0.3 0.6 0.8 0.5 0.3 0.3 0.4 0.3 0.2 0.8 0.1 0.5 0.3 2.0 1.2 0.9 2.0 1.0 3.5 2.0 1.4 2.2 1.3 3.6 1.0 1.8 3.2 4.2 0.0 0.9 1.5 0.9 1.9 6.8 0.4 3.5 4.8 2.6 2.8 2.9 12.9 0.0 0.9 1.1 10.5 7.9 1.9 5.8 0.5 0.2 2.3 7.2 0.0 0.0 4.2 1.9 0.9 2.0 0.2 0.0 0.3 0.7 21.7 1.1 0.0 0.3 3.8 4.1 1.9 5.3 5.3 1.5 2.1 0.0 1.0 6.1 1.0 3.1 0.0 0.0 5.1 11.1 0.7 0.0 0.6 44.2 20.7 1.1 0.5 0.0 0.2 0.9 16.0 2.5 1.0 0.9 0.4 1.4 0.7 6.6 0.6 NAMPT "PBEF, PBEF1" ENSG00000105835 "Nicotinamide phosphoribosyltransferase" P43490 7 106248298-106285966 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Biological rhythms, Pyridine nucleotide biosynthesis" "Cytokine, Glycosyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hepatocytes: 580.0;Langerhans cells: 1123.7;Macrophages: 947.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 7 "neutrophil: 279.2" "Lineage enriched" "Detected in all" 9 "granulocytes: 279.2" "Cell line enhanced" "Detected in all" "HHSteC: 387.5;U-87 MG: 434.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB034349, HPA047776, HPA057722" Approved Approved "Nuclear speckles,Cell Junctions" "Secreted to blood" NA NA 2140000 1400000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 41: Macrophages - Immune response" "Nuclear speckles" "Cell Junctions" "CAB034349: AB_2251220, HPA047776: AB_2680151, HPA057722: " "unprognostic (2.87e-1)" "prognostic unfavorable (4.78e-4)" "unprognostic (5.90e-3)" "unprognostic (1.63e-2)" "unprognostic (1.50e-2)" "prognostic unfavorable (8.81e-4)" "unprognostic (2.15e-1)" "unprognostic (2.74e-2)" "unprognostic (2.74e-1)" "unprognostic (3.30e-1)" "prognostic unfavorable (1.51e-4)" "unprognostic (3.02e-1)" "prognostic unfavorable (2.49e-6)" "unprognostic (6.83e-2)" "unprognostic (6.96e-2)" "unprognostic (7.76e-2)" "unprognostic (6.44e-3)" 308.5 74.2 14.4 360.5 15.6 312.5 103.3 15.2 35.4 47.3 21.7 62.5 38.5 38.6 6.9 228.2 107.6 113.7 103.1 15.2 20.9 82.9 317.9 218.5 23.2 75.7 24.9 58.4 80.9 25.9 30.1 87.3 30.3 70.1 30.3 17.2 126.0 13.4 135.9 54.1 55.9 48.0 21.3 88.2 102.4 11.7 46.3 15.6 42.2 44.4 39.9 283.3 86.7 21.5 103.6 41.0 14.6 16.8 85.8 95.0 34.4 26.1 194.7 57.0 90.6 25.7 38.7 77.7 78.8 32.1 131.5 58.2 38.8 88.1 93.8 50.5 51.7 35.8 17.2 22.6 387.5 61.3 49.4 94.8 94.2 114.9 115.0 70.6 187.3 32.0 70.5 225.6 68.1 49.4 58.1 19.4 36.6 33.6 59.7 25.8 30.4 147.6 46.2 60.8 33.4 19.3 46.0 61.1 107.9 43.0 25.4 9.4 168.2 75.6 52.9 105.9 51.9 212.1 142.7 115.7 434.3 69.3 105.6 39.6 6.5 16.0 1.8 21.8 2.4 3.9 2.2 2.7 7.0 3.4 2.8 2.2 279.2 4.4 30.5 5.5 7.1 4.8 14.4 15.6 15.2 35.4 15.2 20.9 75.7 24.9 30.3 21.3 46.3 21.5 323.8 131.4 245.7 12.1 78.0 207.6 321.0 105.7 169.0 23.8 184.2 132.0 94.8 197.3 161.4 42.3 12.5 26.2 67.5 105.8 46.9 320.6 12.2 128.0 160.8 192.8 25.1 29.5 25.3 141.3 58.9 239.6 132.0 296.5 188.4 18.8 159.5 580.0 107.0 40.4 28.8 51.9 63.1 390.3 1123.7 6.9 40.4 947.3 161.9 46.9 102.7 22.6 9.2 12.1 22.4 138.1 49.7 31.2 93.7 364.0 112.8 50.7 94.1 30.8 26.3 264.6 185.6 30.5 65.8 98.3 207.8 25.3 110.3 38.4 79.4 334.5 NANS SAS ENSG00000095380 "N-acetylneuraminate synthase" Q9NR45 9 98056732-98083077 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Transferase "Disease variant, Dwarfism, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Intestinal goblet cells: 362.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019223 Approved Enhanced Nucleoplasm No No 410000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 4: Stomach - Digestion" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "HPA019223: AB_1854298" "unprognostic (2.95e-1)" "unprognostic (5.10e-3)" "unprognostic (2.24e-2)" "prognostic favorable (1.71e-4)" "unprognostic (7.31e-3)" "unprognostic (1.23e-1)" "prognostic unfavorable (6.42e-4)" "unprognostic (2.08e-1)" "unprognostic (7.98e-2)" "unprognostic (2.28e-1)" "unprognostic (1.54e-2)" "unprognostic (1.12e-1)" "unprognostic (1.31e-2)" "unprognostic (1.64e-1)" "unprognostic (7.36e-2)" "unprognostic (3.62e-3)" "unprognostic (1.79e-1)" 39.4 28.9 16.2 49.3 15.0 67.8 36.5 13.8 18.2 49.9 29.8 133.5 52.2 28.5 33.5 51.4 29.4 34.2 46.3 15.1 17.0 32.8 67.0 45.9 59.5 16.2 17.2 26.2 67.6 20.4 42.5 31.7 18.4 106.4 129.2 8.3 120.0 19.7 34.2 29.2 47.8 29.0 15.1 53.3 76.1 27.2 17.2 18.8 27.3 17.4 60.5 47.5 41.5 17.2 387.9 111.8 32.5 94.5 64.0 68.8 70.5 120.9 93.7 96.3 78.3 134.8 53.6 118.1 57.2 133.3 101.9 134.1 61.0 103.6 80.0 95.7 91.0 70.3 128.4 271.9 176.3 80.3 55.3 58.4 69.1 102.9 116.4 111.8 104.3 57.9 129.9 119.8 71.2 265.0 54.1 114.9 56.2 277.5 143.3 103.4 89.0 121.5 78.2 116.6 65.7 34.4 77.8 414.4 107.2 35.8 137.6 85.3 274.2 74.8 72.5 193.4 125.8 110.7 99.3 45.7 88.4 95.9 59.6 30.9 190.9 29.5 34.9 237.6 53.4 55.6 45.5 36.8 194.7 54.9 48.8 33.7 77.4 38.9 217.0 178.8 58.3 91.4 16.2 15.0 13.8 18.2 15.1 17.0 16.2 17.2 18.4 15.1 17.2 17.2 46.7 28.9 54.9 3.6 57.0 70.1 134.0 183.0 30.7 11.4 61.6 45.5 25.3 42.9 206.3 22.0 18.8 86.7 50.2 234.3 70.5 49.4 42.8 63.4 37.9 63.4 64.9 18.7 6.7 100.7 159.2 50.6 99.4 55.8 43.8 29.5 34.2 33.6 160.0 10.1 7.2 362.7 95.6 67.7 107.6 71.5 32.3 89.8 129.9 6.5 53.1 14.1 14.4 2.0 3.1 70.9 181.0 26.4 141.1 213.6 66.5 68.3 204.5 8.0 13.1 32.9 91.3 10.5 21.9 42.0 61.7 150.8 50.6 44.6 260.1 223.3 NAT1 AAC1 ENSG00000171428 "N-acetyltransferase 1" P18440 8 18170477-18223689 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal enterocytes: 24.2;Paneth cells: 32.7;Respiratory ciliated cells: 32.0" "Cancer enriched" "Detected in all" 14 "breast cancer: 47.9" "Low region specificity" "Detected in some" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "CAB017782, HPA043704" Approved NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 9: Intestine - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "CAB017782: , HPA043704: AB_2678625" "unprognostic (1.31e-1)" "unprognostic (1.05e-1)" "prognostic favorable (5.07e-4)" "unprognostic (2.09e-1)" "unprognostic (2.53e-2)" "unprognostic (8.25e-2)" "unprognostic (5.20e-2)" "unprognostic (6.53e-2)" "unprognostic (6.75e-2)" "unprognostic (1.27e-1)" "unprognostic (1.37e-2)" "unprognostic (9.51e-2)" "unprognostic (6.60e-2)" "unprognostic (7.44e-2)" "unprognostic (2.30e-1)" "unprognostic (3.28e-2)" "unprognostic (8.15e-2)" 3.6 1.5 0.5 5.4 0.7 3.2 5.9 0.8 0.9 6.5 0.8 14.2 11.7 2.4 15.2 2.5 4.4 3.6 1.8 0.5 0.7 5.7 10.4 3.5 6.0 1.2 0.7 2.9 1.8 1.1 1.0 4.1 0.8 7.3 12.8 0.3 1.9 2.9 0.4 2.4 8.9 3.6 0.8 4.1 4.9 1.8 0.8 4.6 2.1 1.5 6.7 4.5 1.3 1.0 22.6 2.7 2.5 3.3 6.3 6.3 5.3 8.0 8.5 8.8 10.2 4.0 4.7 11.0 6.2 5.2 8.1 3.6 4.5 5.4 8.9 10.3 2.3 7.6 3.0 3.0 6.0 3.3 9.7 5.2 6.5 6.0 0.5 2.2 7.9 9.3 6.6 2.9 10.0 4.0 9.8 10.3 2.4 17.8 3.4 4.9 2.5 4.3 9.3 12.6 1.3 1.7 0.3 9.5 5.5 5.2 7.7 9.7 8.5 5.3 3.1 8.0 1.3 2.0 4.0 9.3 4.6 7.5 2.4 5.4 4.6 9.4 3.3 5.3 2.4 4.4 3.4 3.4 6.1 3.9 3.2 3.9 8.2 6.3 5.4 3.5 6.3 2.7 0.5 0.7 0.8 0.9 0.5 0.7 1.2 0.7 0.8 0.8 0.8 1.0 4.6 0.0 3.6 0.7 4.7 0.4 0.8 9.1 1.2 0.0 3.5 1.9 1.6 0.0 11.3 5.5 0.0 5.9 2.3 24.2 1.9 5.7 10.8 3.9 3.2 3.0 3.6 0.8 0.8 6.9 7.7 2.1 3.6 2.8 2.5 1.1 2.2 12.7 7.2 0.0 0.2 10.7 8.2 6.3 2.6 2.2 4.1 5.3 3.6 1.9 4.9 2.5 4.1 0.0 0.5 5.8 32.7 5.7 2.6 2.3 12.7 16.6 32.0 0.0 0.0 0.7 3.4 4.2 0.6 2.2 0.6 10.9 4.1 3.2 8.4 2.5 NAT2 AAC2 ENSG00000156006 "N-acetyltransferase 2" P11245 8 18391282-18401218 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 41 "intestine: 33.5;liver: 128.6" "Group enriched" "Detected in some" 4 "Distal enterocytes: 14.8;Hepatocytes: 59.0;Paneth cells: 15.9;Proximal enterocytes: 36.0" "Cancer enhanced" "Detected in some" "colorectal cancer: 4.0;liver cancer: 4.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "RPTEC TERT1: 1.0;RT4: 1.6;SCLC-21H: 2.2;SK-BR-3: 1.4" HPA043704 Uncertain NA NA "Cluster 85: Liver - Metabolism" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 2: Hepatocytes - Metabolism" "HPA043704: AB_2678625" "unprognostic (2.74e-3)" "unprognostic (4.03e-1)" "prognostic favorable (4.61e-5)" "unprognostic (1.43e-2)" "unprognostic (1.07e-1)" "unprognostic (1.83e-1)" "unprognostic (2.52e-2)" "unprognostic (2.67e-2)" "unprognostic (1.27e-1)" "unprognostic (1.33e-2)" "unprognostic (4.07e-1)" "unprognostic (6.05e-3)" "unprognostic (1.02e-1)" "unprognostic (3.40e-1)" "unprognostic (1.83e-1)" "unprognostic (1.64e-1)" 0.1 0.1 0.2 1.6 0.2 0.0 1.1 0.2 0.6 0.5 0.1 15.0 33.5 0.9 0.7 0.1 0.2 0.2 0.2 0.2 0.2 1.9 128.6 0.2 0.0 0.2 0.2 0.2 0.0 0.0 0.1 0.6 0.1 0.4 13.2 0.0 0.0 0.5 0.0 0.0 25.6 1.6 0.2 1.3 0.1 0.4 0.2 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.1 0.0 0.6 0.0 0.0 0.0 0.5 0.0 0.0 0.1 0.1 0.0 0.2 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.3 0.3 0.0 0.0 0.3 0.0 1.0 1.6 2.2 0.0 0.0 1.4 0.0 0.1 0.3 0.2 0.5 0.3 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.2 0.6 0.2 0.2 0.2 0.2 0.1 0.2 0.2 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.3 0.0 0.0 1.0 0.0 14.8 5.9 0.1 0.1 0.0 0.2 0.1 0.0 0.0 0.1 0.0 1.0 0.1 0.0 0.0 0.0 0.0 0.4 59.0 0.2 0.0 0.0 7.4 0.0 1.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 15.9 2.6 0.0 0.0 36.0 0.8 0.3 0.0 0.0 0.3 0.1 0.3 0.0 0.0 0.0 4.4 0.1 0.8 6.7 0.1 NAT8 "ATase2, GLA, Hcml1, TSC501" ENSG00000144035 "N-acetyltransferase 8 (putative)" Q9UHE5 2 73640723-73642422 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 9 "kidney: 732.4" "Cell type enriched" "Detected in some" 13 "Proximal tubular cells: 2565.5" "Cancer enriched" "Detected in some" 5 "renal cancer: 242.1" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 15 "Hep G2: 10.7" "Low region specificity" "Detected in all" "HPA067855, HPA074519" Enhanced Approved "Endoplasmic reticulum" NA NA "Cluster 7: Kidney - Transmembrane transport" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Endoplasmic reticulum" "HPA067855: AB_2732774, HPA074519: AB_2686699" "unprognostic (4.51e-2)" "unprognostic (6.36e-2)" "unprognostic (1.95e-1)" "unprognostic (1.81e-1)" "unprognostic (1.98e-1)" "unprognostic (4.95e-3)" "unprognostic (2.46e-1)" "unprognostic (1.90e-2)" "unprognostic (9.42e-2)" "unprognostic (1.82e-1)" "unprognostic (2.13e-2)" "unprognostic (8.60e-2)" "unprognostic (1.37e-3)" "unprognostic (2.07e-2)" "unprognostic (4.11e-3)" "unprognostic (2.13e-2)" "unprognostic (8.36e-5)" 0.1 0.3 1.1 0.1 0.5 0.1 0.2 0.1 0.7 0.2 0.0 1.1 4.6 0.1 0.0 0.0 1.2 0.6 0.1 0.8 0.8 732.4 82.7 0.2 0.0 0.6 0.3 1.3 0.2 0.0 0.6 0.0 0.1 0.2 0.1 1.8 0.1 0.1 0.0 0.0 7.2 0.1 0.4 1.1 0.6 0.5 1.0 0.0 0.1 0.0 0.0 0.1 0.1 0.8 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 10.7 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.5 0.1 0.7 0.8 0.8 0.6 0.3 0.1 0.4 1.0 0.8 0.0 0.0 0.0 0.0 19.7 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.5 0.0 36.8 0.0 0.0 0.0 0.3 187.9 0.0 0.0 0.0 0.0 5.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 22.9 51.1 0.0 0.0 0.0 1.1 0.0 1.0 0.4 0.0 0.0 12.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.0 0.0 61.3 2565.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.6 0.0 0.6 0.1 NAT8L "FLJ37478, Hcml3, Shati" ENSG00000185818 "N-acetyltransferase 8 like" Q8N9F0 4 2059327-2069089 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 8 "adipose tissue: 43.5;brain: 99.0" "Cell type enhanced" "Detected in some" "Astrocytes: 126.7;Excitatory neurons: 46.0;Horizontal cells: 80.8;Inhibitory neurons: 37.6;Muller glia cells: 25.0" "Group enriched" "Detected in many" 6 "endometrial cancer: 6.2;glioma: 17.2;melanoma: 14.6;ovarian cancer: 8.0;thyroid cancer: 7.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "NB-4: 20.8;SCLC-21H: 25.8;SK-MEL-30: 21.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040677 Approved Mitochondria NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 65: Brain - Ion transport" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 64: Astrocytes - Nervous system maintenance" Mitochondria "HPA040677: AB_2732486" "unprognostic (1.32e-2)" "unprognostic (8.62e-2)" "unprognostic (3.02e-3)" "prognostic unfavorable (1.01e-5)" "unprognostic (2.56e-1)" "unprognostic (2.63e-4)" "unprognostic (6.58e-2)" "unprognostic (1.79e-1)" "unprognostic (2.90e-2)" "unprognostic (4.54e-1)" "unprognostic (3.70e-2)" "unprognostic (7.06e-2)" "unprognostic (1.78e-3)" "unprognostic (7.24e-3)" "unprognostic (1.14e-2)" "unprognostic (2.10e-2)" "unprognostic (1.35e-2)" 43.5 0.7 56.1 0.1 46.4 0.0 1.6 42.9 99.0 0.0 0.6 0.2 0.1 0.3 1.3 0.1 0.9 0.1 0.8 45.8 29.0 5.3 0.0 0.0 0.2 52.3 46.4 0.2 2.3 0.9 1.8 0.1 57.5 1.0 0.1 3.7 2.3 1.6 5.7 1.0 0.2 0.2 33.0 0.3 0.4 9.0 88.8 0.2 0.3 2.5 0.0 0.0 0.0 38.9 0.1 9.2 4.9 10.0 0.9 0.0 5.7 0.2 0.0 0.2 0.0 4.1 0.3 0.0 1.9 0.0 1.5 0.1 11.1 0.0 0.1 0.0 13.2 0.1 2.1 6.6 1.5 14.5 6.9 0.0 0.2 0.0 0.0 1.8 0.0 3.4 11.5 0.0 0.4 6.2 0.2 20.8 14.1 0.0 4.1 0.7 2.3 0.4 0.2 0.5 25.8 8.6 6.6 0.0 21.4 0.8 0.7 8.3 0.0 0.0 3.3 0.1 5.6 0.0 0.0 0.2 0.0 6.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 56.1 46.4 42.9 99.0 45.8 29.0 52.3 46.4 57.5 33.0 88.8 38.9 0.5 0.0 0.0 126.7 0.0 0.3 0.0 0.0 0.0 14.5 1.4 2.2 2.6 0.0 0.0 1.8 6.2 0.0 5.4 0.0 0.0 4.6 1.1 1.7 0.1 0.4 1.8 0.0 46.0 0.6 0.1 0.2 0.0 1.0 0.0 21.9 0.0 0.0 0.8 80.8 37.6 0.0 0.0 0.0 0.3 3.8 0.0 0.7 10.6 17.8 0.0 25.0 0.0 23.1 15.7 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.0 5.6 0.0 0.0 0.8 0.5 1.5 0.0 0.1 0.0 0.0 0.1 0.0 0.1 NCOA1 "bHLHe74, F-SRC-1, KAT13A, NCoA-1, RIP160, SRC1" ENSG00000084676 "Nuclear receptor coactivator 1" Q15788 2 24491914-24770702 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, Acyltransferase, Transferase" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 467.5;Excitatory neurons: 313.0;Inhibitory neurons: 421.8;Microglial cells: 341.9;Oligodendrocyte precursor cells: 459.4;Oligodendrocytes: 305.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RH-30: 81.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB019402, HPA070213, HPA070520" Supported Enhanced "Nucleoplasm,Plasma membrane,Cytosol" No No "Cluster 5: Granulocytes - Unknown function" "Cluster 58: Brain - Synaptic function" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "Plasma membrane, Cytosol" "CAB019402: AB_2196189, HPA070213: AB_2686235, HPA070520: AB_2686276" "unprognostic (2.73e-1)" "unprognostic (5.82e-2)" "unprognostic (2.46e-2)" "unprognostic (9.89e-3)" "unprognostic (7.60e-2)" "unprognostic (2.36e-2)" "unprognostic (7.06e-3)" "unprognostic (1.45e-1)" "unprognostic (1.43e-1)" "unprognostic (1.72e-1)" "unprognostic (2.93e-3)" "unprognostic (1.16e-1)" "unprognostic (2.10e-2)" "unprognostic (7.15e-2)" "unprognostic (3.08e-1)" "unprognostic (1.29e-1)" "unprognostic (2.92e-2)" 16.6 15.1 24.0 13.3 25.4 17.3 17.3 24.6 28.2 18.6 13.6 15.9 20.9 19.0 12.8 17.6 15.7 14.0 15.3 29.6 19.5 18.9 15.0 16.0 15.3 17.7 19.2 26.6 17.4 30.0 16.6 17.1 16.0 15.2 16.6 47.3 16.0 20.2 33.4 15.7 18.9 19.0 19.5 16.3 12.5 19.9 21.8 26.1 11.8 36.1 16.3 14.9 15.5 22.3 14.1 10.3 17.7 9.2 19.2 17.3 26.9 7.4 14.7 9.1 8.1 9.6 5.9 10.2 3.1 13.5 17.4 3.4 10.7 6.3 9.8 48.6 15.5 36.5 4.1 4.1 12.0 16.9 29.1 27.9 9.4 8.8 7.1 11.3 9.4 12.9 22.6 16.5 14.0 9.4 15.1 6.0 8.5 8.2 6.8 11.8 81.5 5.1 9.9 18.9 16.2 12.8 17.1 10.2 7.4 9.3 12.3 8.6 10.2 15.2 11.9 10.5 7.5 18.8 17.5 17.2 8.6 10.5 7.7 10.6 3.3 7.0 3.4 2.6 3.8 1.6 3.0 3.8 2.5 2.4 2.9 3.5 13.8 3.5 2.9 5.2 3.7 2.0 24.0 25.4 24.6 28.2 29.6 19.5 17.7 19.2 16.0 19.5 21.8 22.3 41.0 38.5 31.5 467.5 16.7 30.5 11.6 7.8 14.2 96.5 32.3 26.7 41.9 17.2 22.8 14.7 52.1 13.1 47.0 39.0 7.9 16.5 29.7 14.6 37.6 34.9 25.2 29.9 313.0 26.6 18.1 39.8 19.9 28.4 20.2 52.9 36.8 22.8 17.9 62.2 421.8 20.7 20.3 29.8 30.3 7.4 47.2 37.7 19.6 341.9 34.7 66.7 78.2 459.4 305.8 20.1 33.5 43.2 14.3 15.7 30.4 12.5 16.9 71.6 39.5 116.9 34.4 37.7 37.6 16.6 31.0 5.3 33.4 27.2 24.1 21.7 NCOA3 "ACTR, AIB1, bHLHe42, CAGH16, KAT13B, p/CIP, RAC3, SRC-3, SRC3, TNRC16, TRAM-1" ENSG00000124151 "Nuclear receptor coactivator 3" Q9Y6Q9 20 47501887-47656877 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, Acyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "B-cells: 155.8;Plasma cells: 168.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "MCF7: 187.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009800, HPA024210" Supported Supported Nucleoplasm,Cytosol NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 16: Immune cells - Immune response" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 57: B-cells - Immune response" Nucleoplasm Cytosol "CAB009800: AB_2251314, HPA024210: AB_10602011" "unprognostic (7.26e-3)" "unprognostic (1.00e-1)" "unprognostic (2.69e-1)" "unprognostic (3.23e-2)" "unprognostic (5.78e-2)" "unprognostic (4.33e-2)" "prognostic unfavorable (8.09e-4)" "unprognostic (2.83e-2)" "unprognostic (1.47e-1)" "unprognostic (5.22e-3)" "unprognostic (2.09e-2)" "unprognostic (2.10e-1)" "unprognostic (2.05e-1)" "unprognostic (1.95e-1)" "unprognostic (2.04e-2)" "unprognostic (4.18e-1)" "unprognostic (1.63e-1)" 14.7 8.2 4.7 22.9 4.7 13.4 11.5 5.7 9.0 11.1 3.8 9.9 8.8 11.8 7.1 14.3 10.7 10.3 13.3 4.0 5.5 9.4 10.5 14.8 35.0 6.5 5.3 14.1 11.1 11.2 6.0 28.1 6.9 9.6 11.2 11.6 11.3 8.8 25.2 14.0 14.8 11.5 5.3 27.5 14.8 7.5 5.9 17.9 12.9 16.5 39.2 15.3 12.5 6.4 17.6 50.1 16.1 21.5 37.5 41.9 105.2 16.4 24.2 27.3 14.1 25.2 19.0 61.8 11.0 28.5 36.1 43.2 12.2 20.7 20.9 31.3 6.4 8.1 15.3 39.3 22.6 6.8 43.3 19.9 61.2 24.4 30.3 23.5 20.0 10.0 18.7 14.0 16.2 187.0 9.9 12.8 5.8 14.2 20.6 17.8 11.0 27.4 16.8 38.2 3.1 5.7 41.0 53.7 18.8 18.0 24.3 17.8 35.8 16.4 12.9 20.5 7.4 38.5 35.9 60.6 19.4 7.0 10.8 2.8 3.9 3.0 2.5 5.2 2.2 9.3 2.3 2.2 5.0 6.8 2.6 2.9 4.5 2.1 5.0 4.2 3.1 2.6 4.7 4.7 5.7 9.0 4.0 5.5 6.5 5.3 6.9 5.3 5.9 6.4 86.7 12.8 23.7 27.7 155.8 34.5 15.7 25.0 52.9 18.1 23.8 13.8 26.1 20.0 29.0 14.7 8.4 69.5 39.9 12.5 5.9 12.9 12.1 36.4 29.1 49.8 14.9 14.9 48.5 19.6 26.2 26.4 26.5 78.8 8.8 15.3 68.2 20.0 22.8 13.5 64.3 10.7 36.7 46.8 62.2 6.0 24.8 58.2 33.8 109.6 46.1 9.3 28.8 49.3 54.1 21.0 16.9 27.4 168.8 28.1 9.0 6.5 39.8 23.8 19.7 19.7 30.3 43.2 30.0 63.3 51.7 89.2 47.6 14.2 11.7 59.2 NDST1 "HSST, NST1" ENSG00000070614 "N-deacetylase and N-sulfotransferase 1" P52848 5 150485818-150558211 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Inflammatory response" "Hydrolase, Multifunctional enzyme, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Hepatocytes: 47.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 8 "basophil: 1.4;classical monocyte: 5.5;eosinophil: 3.6;intermediate monocyte: 1.7;myeloid DC: 4.2;neutrophil: 5.4;non-classical monocyte: 4.7" "Group enriched" "Detected in many" 10 "dendritic cells: 4.2;granulocytes: 5.4;monocytes: 5.5" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA060532 Approved NA NA 1400000 "Cluster 14: Monocytes - Unknown function" "Cluster 15: Liver - Metabolism" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "HPA060532: AB_2684310" "unprognostic (1.36e-1)" "unprognostic (5.54e-3)" "unprognostic (1.48e-1)" "prognostic unfavorable (6.99e-4)" "unprognostic (1.77e-1)" "unprognostic (3.37e-2)" "unprognostic (1.06e-1)" "unprognostic (1.47e-2)" "unprognostic (2.73e-1)" "prognostic unfavorable (5.13e-4)" "unprognostic (4.97e-3)" "unprognostic (6.92e-2)" "unprognostic (7.45e-2)" "unprognostic (2.46e-2)" "unprognostic (1.29e-1)" "unprognostic (1.26e-1)" "unprognostic (6.08e-2)" 37.2 22.7 39.4 14.0 45.1 7.6 28.6 43.8 38.9 16.0 3.9 17.6 12.5 17.3 7.9 38.8 14.7 15.2 26.8 30.8 30.7 15.4 42.6 34.3 7.3 62.6 48.8 23.0 39.7 20.5 6.7 12.2 50.3 14.5 9.5 13.9 37.4 16.8 23.6 34.2 17.4 19.2 47.8 43.4 16.0 14.5 51.5 4.2 22.9 13.0 9.9 14.1 18.7 60.0 32.4 28.3 46.1 56.4 45.3 44.9 46.3 58.1 75.9 56.8 84.8 84.1 33.3 22.0 57.6 116.8 91.0 54.4 25.1 118.0 37.6 2.6 38.9 26.0 18.5 13.2 33.5 19.5 45.5 61.6 48.1 68.7 31.0 56.9 78.3 12.9 25.3 7.8 56.3 27.5 2.3 6.2 21.6 9.1 33.0 37.6 38.4 9.8 33.4 32.5 13.8 48.3 35.2 108.5 46.3 32.7 58.3 4.8 38.8 96.4 86.2 42.3 48.3 17.1 4.7 8.1 79.2 30.1 38.0 1.4 5.5 3.6 0.1 1.7 0.0 0.4 0.0 0.4 4.2 0.1 0.0 0.2 5.4 0.0 4.7 0.3 0.0 2.8 39.4 45.1 43.8 38.9 30.8 30.7 62.6 48.8 50.3 47.8 51.5 60.0 29.8 38.5 8.7 23.8 1.9 5.7 3.5 14.4 6.2 11.6 29.9 15.4 11.5 17.2 9.6 16.5 8.4 8.6 0.5 20.9 1.9 10.4 0.7 5.5 7.7 35.5 1.2 3.2 12.0 10.5 11.3 11.0 2.0 6.8 1.3 20.4 31.8 47.5 7.7 13.5 11.7 5.3 8.2 14.4 7.6 1.9 12.5 8.7 10.6 16.9 7.4 12.1 0.0 12.1 39.7 18.8 6.6 32.0 3.7 7.9 17.8 8.8 3.8 11.3 0.0 8.7 11.5 0.7 1.6 17.4 12.4 4.5 1.2 11.8 5.8 5.3 NDST2 "HSST2, NST2" ENSG00000166507 "N-deacetylase and N-sulfotransferase 2" P52849 10 73801911-73811798 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Hydrolase, Multifunctional enzyme, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 13.7;granulocytes: 14.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HMC-1: 110.2" HPA051515 Approved Approved Cytosol NA NA 130000 "Cluster 32: T-cells - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 3: HMC-1 - Innate immune response" "Cluster 59: Non-specific - Transcription" Cytosol "HPA051515: AB_2681517" "unprognostic (8.84e-2)" "unprognostic (7.57e-2)" "unprognostic (2.53e-2)" "unprognostic (9.43e-3)" "unprognostic (5.69e-1)" "unprognostic (1.07e-2)" "unprognostic (5.83e-3)" "unprognostic (2.16e-2)" "unprognostic (8.19e-2)" "unprognostic (1.61e-2)" "unprognostic (2.23e-5)" "unprognostic (1.49e-2)" "unprognostic (4.08e-7)" "unprognostic (3.71e-2)" "unprognostic (3.69e-2)" "unprognostic (5.93e-2)" "unprognostic (9.06e-2)" 14.9 16.7 11.6 19.6 11.6 53.6 13.3 15.7 14.2 15.7 10.6 13.6 10.7 15.7 11.6 16.8 15.0 15.1 11.4 11.6 11.7 14.4 10.9 17.0 24.6 12.6 11.4 15.8 14.1 18.4 15.8 12.5 11.2 15.6 12.1 14.9 17.7 14.2 8.9 18.8 17.4 15.8 10.4 35.3 13.6 13.6 12.5 31.9 13.3 8.5 23.9 15.3 15.4 11.5 10.0 7.9 16.7 26.2 20.9 23.0 9.1 12.3 24.5 13.4 13.3 4.6 12.4 9.5 7.1 21.8 13.6 11.6 8.1 11.8 9.6 23.4 8.5 9.3 7.0 7.3 36.7 11.8 110.2 22.9 14.5 21.4 22.4 41.1 17.5 17.9 9.2 33.8 16.6 8.1 12.7 13.4 4.5 6.4 36.4 8.5 8.2 5.9 11.5 7.2 5.5 9.0 9.9 23.5 7.5 11.3 18.6 18.6 29.5 6.3 7.8 9.1 8.4 17.4 8.0 11.8 7.2 17.0 5.5 0.7 2.7 1.1 2.7 1.9 3.1 1.2 2.3 2.3 2.0 1.3 2.6 3.4 2.8 1.1 1.7 3.4 1.6 1.8 11.6 11.6 15.7 14.2 11.6 11.7 12.6 11.4 11.2 10.4 12.5 11.5 1.5 0.0 3.0 13.7 5.4 1.3 0.8 0.6 1.2 0.7 4.1 2.3 1.8 0.0 1.8 0.0 0.0 1.4 3.6 4.7 0.0 5.4 7.5 0.8 1.2 1.1 2.4 7.8 7.5 9.6 1.5 1.9 4.6 0.7 14.5 0.3 1.4 4.2 5.2 1.7 7.6 2.6 2.0 8.5 3.1 10.4 0.0 10.8 1.8 2.8 5.4 0.8 0.0 5.0 5.0 7.0 3.2 0.0 10.6 1.3 2.4 7.4 2.7 0.8 0.0 1.4 1.5 2.3 1.7 4.7 1.6 6.2 5.3 0.3 2.2 1.9 NDST3 HSST3 ENSG00000164100 "N-deacetylase and N-sulfotransferase 3" O95803 4 118033618-118258634 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Multifunctional enzyme, Transferase" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Group enriched" "Detected in some" 5 "brain: 4.8;liver: 1.3;lymphoid tissue: 2.9;retina: 2.7" "Group enriched" "Detected in some" 5 "Excitatory neurons: 299.6;Inhibitory neurons: 128.6" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 10 "MOLT-4: 17.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA056189 Uncertain NA NA "Cluster 58: Brain - Synaptic function" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA056189: AB_2683061" "unprognostic (1.95e-2)" "unprognostic (7.58e-2)" "unprognostic (4.34e-3)" "unprognostic (2.55e-7)" "unprognostic (4.05e-2)" "unprognostic (2.18e-2)" "unprognostic (2.86e-3)" "unprognostic (2.32e-2)" "unprognostic (1.87e-1)" "unprognostic (1.46e-2)" "unprognostic (7.43e-2)" "unprognostic (1.99e-2)" "unprognostic (1.09e-3)" "unprognostic (1.37e-1)" "unprognostic (4.39e-3)" "unprognostic (6.83e-2)" "unprognostic (8.85e-2)" 0.0 0.5 1.2 0.0 4.8 0.0 0.0 3.3 2.8 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 1.5 1.0 0.1 1.3 0.0 0.1 0.6 0.8 0.1 0.0 0.0 0.5 0.0 0.0 0.0 0.0 2.7 0.0 0.2 0.0 0.0 0.0 0.0 0.0 2.0 0.2 0.0 0.4 2.9 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.0 0.0 1.6 0.0 0.0 0.0 0.0 17.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.8 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 4.8 3.3 2.8 1.5 1.0 0.6 0.8 0.0 0.0 0.4 0.0 0.2 0.0 0.0 8.5 0.0 0.0 0.0 0.0 0.0 20.7 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 299.6 0.0 0.0 0.2 0.0 0.1 0.0 0.4 0.4 0.6 0.1 6.7 128.6 0.2 0.0 42.1 0.0 0.0 0.0 0.0 0.0 6.5 0.0 0.3 0.0 12.1 18.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.1 NDST4 ENSG00000138653 "N-deacetylase and N-sulfotransferase 4" Q9H3R1 4 114827763-115113876 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Multifunctional enzyme, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 6 "brain: 9.0" "Group enriched" "Detected in some" 4 "Inhibitory neurons: 29.3;Oligodendrocyte precursor cells: 15.6" "Not detected" "Not detected" "Group enriched" "Detected in many" 5 "hypothalamus: 2.3;medulla oblongata: 8.3;midbrain: 3.5;pons: 9.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 2.9;CACO-2: 3.7;RH-30: 14.5;T-47d: 3.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA011129 Uncertain NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA011129: AB_1079460" "unprognostic (5.58e-2)" "unprognostic (5.90e-2)" "unprognostic (4.82e-1)" "unprognostic (1.71e-2)" "unprognostic (1.08e-1)" "unprognostic (1.11e-1)" "unprognostic (1.94e-1)" "unprognostic (6.55e-2)" 0.0 0.0 0.7 0.0 1.1 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.1 0.0 0.6 2.3 0.0 0.0 0.0 0.0 8.3 3.5 1.5 0.0 0.0 0.0 0.0 9.0 0.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.6 0.7 0.3 0.2 1.2 0.0 0.0 0.0 0.0 0.1 0.0 0.5 0.0 0.0 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.5 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 1.1 0.0 0.2 0.6 2.3 8.3 3.5 9.0 0.6 1.2 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 29.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.7 0.0 0.0 0.0 15.6 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.6 0.0 0.0 0.0 0.0 0.3 0.0 0.0 NDUFAF7 "C2orf56, MidA, PRO1853" ENSG00000003509 "NADH:ubiquinone oxidoreductase complex assembly factor 7" Q7L592 2 37231631-37253403 "Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 38.8" "Group enriched" "Detected in all" 4 "Early spermatids: 196.6;Late spermatids: 109.6;Spermatocytes: 118.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA045217 Uncertain NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 43: Testis - Unknown function" "Cluster 39: CACO-2 - Unknown function" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA045217: AB_10960395" "unprognostic (6.38e-2)" "unprognostic (2.92e-2)" "unprognostic (2.13e-1)" "unprognostic (1.38e-2)" "unprognostic (1.17e-1)" "unprognostic (2.15e-1)" "prognostic unfavorable (1.48e-4)" "prognostic favorable (3.08e-4)" "unprognostic (5.44e-2)" "unprognostic (1.55e-2)" "unprognostic (9.88e-2)" "unprognostic (8.12e-3)" "unprognostic (5.94e-2)" "unprognostic (3.48e-2)" "unprognostic (1.03e-1)" "unprognostic (5.73e-2)" "unprognostic (8.67e-3)" 6.2 12.7 6.7 5.4 7.1 6.0 6.0 7.7 7.8 8.0 6.2 12.1 4.6 7.8 8.0 5.6 6.0 5.9 15.5 7.3 6.6 9.3 10.6 5.5 6.9 6.5 6.5 7.0 5.7 8.2 6.8 5.9 6.8 6.6 5.9 10.0 5.7 5.4 20.4 4.9 5.7 7.3 5.8 6.6 6.2 38.8 6.2 8.2 5.1 24.4 5.9 6.7 6.1 7.1 20.2 10.6 13.2 11.6 8.3 17.6 7.3 6.6 10.5 11.1 14.1 22.9 8.5 17.1 8.1 6.0 18.9 14.8 16.2 8.3 13.1 11.9 12.1 12.6 13.1 21.1 10.2 12.6 6.1 13.8 13.6 9.1 5.6 11.8 17.4 6.4 15.5 11.1 6.7 7.4 12.6 13.5 17.3 15.9 9.5 11.3 10.2 14.4 15.4 7.4 13.7 11.0 8.2 13.9 14.3 18.6 8.4 4.9 3.4 9.2 12.3 11.6 12.1 9.7 6.0 19.8 13.4 16.9 7.9 3.0 4.3 2.6 4.1 3.7 1.8 4.7 3.6 3.5 5.3 4.1 3.5 3.1 2.7 4.1 2.7 4.2 4.6 2.0 6.7 7.1 7.7 7.8 7.3 6.6 6.5 6.5 6.8 5.8 6.2 7.1 10.9 9.6 10.0 12.7 15.5 4.8 9.5 12.3 11.4 18.1 6.4 5.6 13.4 2.8 8.4 11.0 22.9 15.0 16.1 3.7 17.6 10.5 196.6 6.6 12.1 9.4 2.4 6.5 30.5 6.3 10.8 9.7 8.6 7.2 7.6 11.9 7.5 5.6 9.4 11.8 26.9 5.5 12.2 7.3 7.8 109.6 13.4 9.4 3.6 15.0 10.5 7.6 10.3 13.6 15.4 8.8 2.0 16.6 9.3 5.9 7.7 14.8 11.3 21.8 6.6 10.1 18.0 118.4 14.4 7.4 4.0 11.5 13.6 16.1 6.2 6.3 NEDD4 "KIAA0093, MGC176705, NEDD4-1, RPF1" ENSG00000069869 "NEDD4 E3 ubiquitin protein ligase" P46934 15 55826922-55993660 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Transporters" "Host-virus interaction, Neurogenesis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 67.6;tongue: 58.1" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 93.0;Alveolar cells type 2: 116.7;granulocytes: 73.2;Oligodendrocyte precursor cells: 69.9;Respiratory ciliated cells: 75.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB001991, HPA039883, CAB072833" Approved Approved Cytosol NA NA 6500 "Cluster 39: Non-specific - mRNA processing" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 11: Alveolar cells - Smell perception" Cytosol "CAB001991: , CAB072833: , HPA039883: AB_10795683" "unprognostic (1.18e-1)" "unprognostic (2.10e-2)" "unprognostic (5.66e-3)" "unprognostic (1.15e-1)" "unprognostic (6.97e-2)" "unprognostic (2.23e-1)" "unprognostic (3.18e-3)" "prognostic unfavorable (5.14e-4)" "unprognostic (1.36e-2)" "unprognostic (1.62e-1)" "unprognostic (4.96e-2)" "unprognostic (1.43e-2)" "prognostic unfavorable (3.74e-6)" "unprognostic (6.38e-3)" "unprognostic (2.98e-1)" "unprognostic (2.22e-1)" "unprognostic (2.35e-2)" 6.2 3.6 1.7 4.0 2.0 6.2 6.9 1.9 2.0 5.4 1.9 5.7 4.1 7.1 2.9 4.3 3.5 5.6 4.5 1.5 2.7 6.7 27.4 5.3 3.1 2.5 1.9 4.0 1.8 5.4 2.1 15.6 2.6 5.5 4.4 4.5 3.1 7.6 67.6 9.2 8.1 8.0 2.0 4.9 3.4 1.8 2.2 5.6 7.1 58.1 3.0 5.6 4.4 2.6 21.5 32.8 9.0 8.8 11.5 18.5 14.1 40.0 62.9 29.1 28.5 14.5 6.3 4.8 10.4 15.4 70.2 34.6 9.7 26.3 48.2 11.1 5.6 26.1 7.2 7.9 59.0 10.6 2.3 30.8 64.7 35.2 58.9 14.2 24.3 14.9 11.5 0.0 86.4 10.7 15.2 0.1 2.2 10.9 5.1 10.5 67.5 3.1 11.9 42.3 0.7 5.1 17.4 12.5 15.7 15.8 15.2 8.8 84.5 63.9 20.6 13.5 66.0 3.4 8.1 12.3 42.0 24.6 15.7 0.0 0.1 0.0 0.1 0.4 0.3 0.0 0.2 0.1 0.0 0.0 0.2 0.2 0.2 0.1 0.2 0.2 0.1 0.1 1.7 2.0 1.9 2.0 1.5 2.7 2.5 1.9 2.6 2.0 2.2 2.6 35.9 93.0 116.7 28.4 1.6 12.1 3.4 5.5 8.6 0.7 4.6 8.0 5.7 7.2 44.8 0.0 22.9 23.2 2.0 5.2 1.9 3.3 1.7 1.7 13.3 31.1 0.0 17.5 4.2 5.8 7.5 18.5 5.1 1.6 73.2 4.2 17.5 20.5 4.7 0.0 11.9 4.0 2.0 2.2 2.3 1.6 5.6 8.8 1.8 30.0 1.1 8.6 6.2 69.9 28.7 2.9 0.8 7.2 1.9 4.5 25.8 13.4 75.5 6.7 0.0 11.5 17.7 5.3 7.2 7.1 10.4 13.8 9.4 4.8 5.6 1.9 NEDD4L "KIAA0439, NEDD4-2, RSP5" ENSG00000049759 "NEDD4 like E3 ubiquitin protein ligase" Q96PU5 18 58044226-58401540 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Differentiation, Host-virus interaction, Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 253.2;Excitatory neurons: 280.9" "Cancer enhanced" "Detected in all" "prostate cancer: 29.1" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 4 "T-reg: 5.1" "Lineage enriched" "Detected in many" 4 "T-cells: 5.1" "Cell line enhanced" "Detected in many" "SK-MEL-30: 146.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA024618 Approved "Intracellular and membrane" NA NA "Cluster 35: T-regs - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA024618: AB_1854362" "unprognostic (2.56e-1)" "unprognostic (2.41e-2)" "unprognostic (1.58e-2)" "unprognostic (3.14e-1)" "unprognostic (3.90e-2)" "unprognostic (1.50e-1)" "unprognostic (2.11e-3)" "unprognostic (2.26e-2)" "unprognostic (9.24e-3)" "unprognostic (4.39e-2)" "unprognostic (1.24e-1)" "unprognostic (1.27e-1)" "prognostic favorable (6.55e-15)" "unprognostic (2.42e-1)" "unprognostic (8.26e-2)" "unprognostic (8.49e-3)" "unprognostic (4.75e-2)" 11.2 16.8 20.9 6.7 34.4 27.0 25.8 25.1 31.3 7.6 0.7 38.8 18.7 5.3 10.0 12.0 9.1 9.5 26.9 32.3 16.2 53.4 36.5 47.9 4.1 10.9 18.4 6.4 60.5 13.6 28.4 12.0 10.4 64.2 42.8 20.5 27.5 20.4 34.0 11.2 33.8 6.2 8.6 7.9 51.5 7.8 16.7 4.5 17.4 13.1 7.9 19.4 5.9 16.3 70.7 24.5 14.6 20.9 5.1 2.1 49.8 19.2 88.2 48.6 74.6 28.6 37.1 15.1 57.7 7.4 51.3 50.3 19.5 86.1 100.8 34.9 15.5 10.6 14.3 111.3 2.4 0.5 6.0 13.0 54.6 66.4 78.8 39.1 4.0 13.2 18.7 6.3 20.0 16.2 1.0 1.0 12.2 26.7 33.3 14.3 20.1 17.6 47.0 88.7 17.5 5.0 16.1 5.1 146.1 28.3 29.4 5.6 28.8 131.5 38.5 7.5 83.4 8.3 15.3 9.5 27.6 10.8 10.8 0.7 0.3 1.2 0.2 0.3 0.5 0.8 0.6 0.1 0.1 0.3 0.3 0.2 0.2 0.3 0.1 0.1 5.1 0.3 20.9 34.4 25.1 31.3 32.3 16.2 10.9 18.4 10.4 8.6 16.7 16.3 6.0 253.2 144.8 110.4 5.1 112.8 161.2 34.0 86.6 18.1 99.5 65.9 47.8 64.3 112.8 62.5 173.0 13.0 3.6 144.5 49.0 35.7 22.6 64.0 7.3 14.7 45.2 57.9 280.9 49.2 4.7 9.5 114.7 75.0 3.8 4.7 17.5 41.3 7.3 62.2 173.3 201.5 101.7 8.4 8.2 6.6 3.4 13.3 14.2 88.1 7.3 45.2 2.1 11.1 105.0 49.9 145.3 17.7 12.7 126.9 127.3 91.6 72.7 10.0 0.0 34.3 6.0 1.1 12.5 62.3 53.0 80.0 6.6 8.2 72.9 155.5 NEK1 "KIAA1901, NY-REN-55" ENSG00000137601 "NIMA related kinase 1" Q96PY6 4 169392809-169612627 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Cilium biogenesis/degradation, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Amyotrophic lateral sclerosis, Ciliopathy, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 162.6;Excitatory neurons: 126.3;Inhibitory neurons: 170.5;Oligodendrocytes: 196.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020873, HPA040413" Approved Supported "Nucleoplasm,Centriolar satellite,Cytosol" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 21: Non-specific - Transcription" "Cluster 2: Karpas-707 - Immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Cytosol "Nucleoplasm, Centriolar satellite" "HPA020873: AB_10671583, HPA040413: AB_10671169" "unprognostic (4.10e-2)" "unprognostic (2.97e-1)" "unprognostic (1.59e-2)" "unprognostic (1.97e-1)" "unprognostic (6.98e-2)" "unprognostic (3.10e-1)" "unprognostic (3.95e-1)" "unprognostic (3.29e-1)" "unprognostic (1.13e-1)" "unprognostic (2.78e-1)" "unprognostic (4.06e-3)" "unprognostic (2.21e-1)" "prognostic favorable (1.42e-4)" "unprognostic (1.07e-1)" "unprognostic (1.03e-1)" "unprognostic (2.10e-2)" "unprognostic (3.46e-1)" 6.0 6.1 5.1 4.9 6.8 4.2 5.2 7.1 5.3 7.6 2.7 4.0 3.2 7.3 2.8 4.6 9.3 6.1 6.9 3.5 8.8 5.9 4.2 4.6 5.3 7.5 7.7 9.4 4.0 6.5 2.9 4.3 7.6 6.7 4.4 8.7 4.2 6.0 3.3 2.3 3.5 6.6 7.6 5.1 4.9 11.8 5.3 6.8 7.9 4.6 4.6 5.6 2.8 7.7 5.8 2.5 10.0 11.0 15.5 17.1 3.3 11.9 10.6 9.3 8.8 3.3 6.7 15.4 2.2 10.4 9.0 1.9 9.7 10.1 10.5 16.9 6.5 10.3 10.4 3.9 9.0 10.6 7.9 13.7 5.9 9.5 16.7 19.1 9.3 14.5 18.6 28.2 12.1 3.7 13.6 4.6 3.3 3.6 6.0 8.4 6.5 4.9 9.7 6.8 11.0 12.5 8.6 4.2 8.1 7.7 5.3 4.6 11.2 6.0 5.4 6.2 8.1 11.3 18.6 11.6 9.7 5.1 10.7 5.1 0.9 0.9 1.9 1.5 2.2 2.0 1.5 1.2 0.7 2.0 2.2 2.3 0.6 1.1 0.7 1.6 1.6 0.7 5.1 6.8 7.1 5.3 3.5 8.8 7.5 7.7 7.6 7.6 5.3 7.7 12.2 12.8 16.4 162.6 34.2 9.6 15.8 12.1 21.1 21.8 11.3 12.7 37.2 4.3 17.8 18.4 29.2 20.8 17.0 6.4 17.6 10.4 109.7 67.2 21.6 13.2 7.2 26.7 126.3 6.2 8.6 25.0 17.3 23.7 18.3 20.1 9.7 7.8 10.7 18.5 170.5 5.6 20.3 7.0 7.4 48.2 23.6 14.5 5.4 53.4 6.6 26.1 15.5 115.1 196.1 8.9 4.0 31.6 23.2 6.9 5.3 9.6 68.4 24.9 13.1 32.8 25.5 67.9 37.3 21.3 6.3 29.6 22.0 26.0 6.3 9.2 NEK10 FLJ32685 ENSG00000163491 "NIMA related kinase 10" Q6ZWH5 3 27110085-27369460 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Ciliopathy, Disease variant, Primary ciliary dyskinesia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 36.6;tongue: 20.0" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 87.6;Early spermatids: 123.5;Endometrial ciliated cells: 59.3;Excitatory neurons: 131.4;Inhibitory neurons: 130.2;Late spermatids: 61.7;Respiratory ciliated cells: 104.2" "Cancer enriched" "Detected in single" 5 "breast cancer: 1.8" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BJ: 6.0;LHCN-M2: 8.2;U-2 OS: 6.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA038941 Uncertain Approved Nucleoplasm,Vesicles NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 49: Ciliated cells - Cilium organization" Vesicles Nucleoplasm "HPA038941: AB_10673600" "prognostic favorable (4.20e-4)" "unprognostic (2.17e-1)" "unprognostic (8.78e-2)" "unprognostic (2.15e-2)" "unprognostic (3.37e-2)" "unprognostic (3.02e-1)" "unprognostic (1.12e-1)" "unprognostic (1.83e-1)" "unprognostic (1.26e-1)" "unprognostic (1.93e-2)" "unprognostic (2.20e-3)" "unprognostic (1.37e-1)" "unprognostic (7.67e-2)" "unprognostic (1.33e-2)" "unprognostic (1.38e-2)" "unprognostic (1.57e-3)" "unprognostic (2.14e-1)" 0.2 0.3 3.0 0.3 5.3 0.3 14.0 0.0 9.4 1.4 3.3 2.0 2.5 0.8 8.3 1.8 11.0 1.4 3.3 9.6 5.0 1.7 2.5 2.4 0.5 3.3 5.7 0.7 0.7 0.4 3.4 0.1 2.7 1.7 0.5 6.2 0.3 1.2 12.4 0.3 0.8 0.3 2.3 0.4 1.0 36.6 6.1 0.5 0.7 20.0 0.6 1.2 0.2 0.9 0.8 1.6 0.8 0.9 0.6 1.5 0.3 6.0 0.9 1.6 1.4 0.0 0.4 0.5 1.4 2.5 1.1 0.1 0.4 0.4 1.7 1.1 0.6 0.1 3.4 2.9 0.1 0.3 0.8 1.8 0.4 2.5 0.1 2.0 1.1 3.4 0.1 0.6 8.2 0.1 0.6 0.4 0.5 0.2 0.2 0.8 0.3 0.2 3.0 0.5 0.1 0.2 0.9 0.3 0.4 0.5 4.8 0.3 0.7 4.3 6.8 0.2 0.6 0.2 0.2 0.4 3.6 0.7 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 3.0 5.3 0.0 9.4 9.6 5.0 3.3 5.7 2.7 2.3 6.1 0.9 1.5 6.4 0.0 11.4 0.3 0.3 0.3 3.2 0.0 14.5 25.8 7.4 12.9 4.3 9.3 1.8 87.6 0.0 0.8 0.2 0.0 0.4 123.5 59.3 1.3 2.4 0.0 0.0 131.4 0.0 0.3 3.1 0.0 7.7 0.0 1.1 0.7 1.3 0.2 0.0 130.2 0.4 12.2 1.0 0.8 61.7 1.8 1.1 0.0 32.8 0.1 1.0 1.0 20.6 12.9 0.2 2.7 1.2 0.1 1.9 2.1 0.3 104.2 19.1 0.0 14.9 2.4 32.2 2.2 0.1 0.4 0.0 1.1 3.7 0.6 0.4 NEK11 FLJ23495 ENSG00000114670 "NIMA related kinase 11" Q8NG66 3 131026850-131350465 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 26.2" "Cell type enhanced" "Detected in many" "Astrocytes: 60.7;Early spermatids: 156.4;Endometrial ciliated cells: 69.2;Excitatory neurons: 91.0;Late spermatids: 109.2;Respiratory ciliated cells: 102.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA016908 Approved Supported Nucleoplasm NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 49: Ciliated cells - Cilium organization" Nucleoplasm "HPA016908: AB_1854364" "unprognostic (9.15e-3)" "prognostic favorable (7.10e-4)" "unprognostic (1.05e-1)" "unprognostic (1.08e-1)" "unprognostic (9.96e-2)" "unprognostic (4.85e-3)" "unprognostic (2.48e-5)" "unprognostic (5.38e-2)" "unprognostic (1.86e-1)" "unprognostic (1.18e-1)" "unprognostic (2.27e-1)" "unprognostic (1.79e-1)" "prognostic favorable (5.92e-6)" "unprognostic (2.46e-2)" "unprognostic (1.60e-1)" "unprognostic (2.72e-2)" "unprognostic (1.58e-1)" 3.1 4.3 8.3 0.5 8.3 0.1 6.6 6.9 7.7 5.4 26.2 2.1 1.3 4.9 7.1 2.3 21.4 4.6 2.1 7.3 9.0 6.3 0.6 4.3 1.0 14.2 15.5 6.4 2.2 4.8 5.6 2.2 12.4 2.9 2.4 5.6 2.9 3.7 1.1 2.2 1.8 2.7 12.8 1.2 1.6 15.5 9.3 0.9 9.6 0.8 1.2 2.8 2.5 12.8 5.7 2.2 1.6 4.8 6.2 9.3 0.9 2.7 5.0 4.1 3.1 2.1 7.7 0.2 1.9 4.8 3.9 3.0 0.4 4.6 5.6 0.5 0.6 0.8 0.3 1.0 2.1 0.6 1.3 3.9 7.7 4.2 1.9 4.3 0.8 2.4 0.2 0.8 6.9 3.9 0.1 0.4 0.5 0.9 2.1 0.0 0.1 0.1 9.3 2.2 2.0 2.2 1.3 0.1 1.9 0.7 4.4 0.1 0.9 4.1 2.0 3.3 1.3 1.2 2.2 0.1 2.9 0.2 0.7 0.0 0.0 0.2 0.1 0.3 0.2 0.1 0.6 0.5 0.1 0.1 0.2 0.1 0.1 0.0 0.2 0.2 0.3 0.0 8.3 8.3 6.9 7.7 7.3 9.0 14.2 15.5 12.4 12.8 9.3 12.8 2.5 16.0 3.2 60.7 1.5 4.2 3.4 4.5 4.6 2.6 7.3 7.5 1.6 4.3 18.8 1.8 6.2 1.0 1.4 3.3 5.9 6.4 156.4 69.2 6.1 3.5 2.4 0.4 91.0 2.5 1.1 7.7 2.6 6.6 0.0 8.1 5.7 0.6 2.0 0.0 42.0 3.5 6.1 0.3 1.7 109.2 6.8 2.0 0.0 21.5 0.8 6.4 1.0 38.7 38.9 3.7 3.9 6.0 0.8 1.6 1.7 10.6 102.7 7.3 6.6 7.2 3.7 33.4 5.2 2.6 2.0 1.6 1.4 11.5 2.4 2.7 NEK2 "NEK2A, NLK1, PPP1R111, RP67" ENSG00000117650 "NIMA related kinase 2" P51955 1 211658657-211675630 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Chromosome partition, Meiosis, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "bone marrow: 17.9;lymphoid tissue: 19.2;testis: 67.1" "Group enriched" "Detected in many" 4 "Early spermatids: 76.1;Spermatocytes: 244.2" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Region enhanced" "Detected in many" "cerebellum: 5.7" "Low region specificity" "Detected in all" "CAB017530, HPA064967" Enhanced Supported Nucleoplasm,Centrosome NA Yes "Cluster 41: Basophils - Cellular respiration" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" "Nucleoplasm, Centrosome" "CAB017530: AB_1126558, HPA064967: AB_2685393" "unprognostic (1.28e-1)" "unprognostic (2.33e-1)" "unprognostic (1.02e-1)" "unprognostic (8.51e-2)" "unprognostic (1.83e-1)" "unprognostic (1.35e-2)" "prognostic unfavorable (9.47e-6)" "prognostic unfavorable (9.11e-4)" "unprognostic (1.95e-2)" "unprognostic (2.00e-2)" "unprognostic (1.09e-3)" "unprognostic (8.49e-2)" "unprognostic (0.00e+0)" "unprognostic (8.21e-2)" "unprognostic (4.11e-2)" "unprognostic (1.25e-2)" "unprognostic (2.71e-1)" 0.7 0.4 0.5 5.3 0.4 17.9 1.5 0.9 0.6 1.1 0.6 5.9 7.4 1.3 0.5 4.4 2.2 0.8 0.4 0.5 0.3 0.3 0.7 0.7 9.0 0.4 0.2 0.4 0.1 0.1 0.0 3.2 0.3 2.5 7.6 1.5 0.8 0.2 0.4 4.3 6.9 2.0 0.2 1.7 2.7 67.1 0.6 19.2 0.4 0.2 10.6 1.3 1.6 0.9 86.0 60.5 45.3 32.6 2.6 4.5 49.7 32.4 30.1 55.4 47.5 32.3 81.7 45.1 15.2 25.2 35.1 44.5 39.9 24.2 69.6 69.5 33.2 21.6 51.4 44.2 0.4 43.2 28.3 1.4 2.9 42.9 45.9 13.4 36.3 45.2 59.9 76.9 56.0 23.6 47.3 28.8 43.0 55.0 30.5 46.2 69.2 68.7 19.7 24.2 41.0 45.0 46.6 51.5 39.3 38.4 79.4 25.1 19.0 27.6 54.1 54.8 88.3 31.6 62.6 59.6 24.1 32.6 46.8 1.2 0.1 0.1 0.1 0.1 0.0 0.5 0.1 0.1 0.0 0.4 0.3 0.2 0.7 1.5 0.1 0.2 1.6 0.3 0.5 0.4 0.9 0.6 0.5 0.3 0.4 0.2 0.3 0.2 0.6 0.9 0.1 0.0 0.5 0.3 1.7 2.9 0.7 3.8 0.6 11.3 1.9 2.2 0.5 0.0 2.9 0.0 0.0 9.4 0.8 1.9 0.0 0.2 76.1 15.2 0.7 0.8 0.0 39.6 0.8 0.2 14.1 1.4 5.6 1.5 0.0 3.6 3.6 0.7 5.8 3.3 0.0 3.2 10.2 2.5 1.1 39.0 2.5 2.1 0.0 0.0 0.0 1.6 2.1 0.0 0.1 0.0 2.5 0.7 5.4 0.7 2.1 0.1 5.2 1.8 6.6 0.0 1.5 244.2 26.1 8.6 1.7 1.4 2.0 0.9 9.5 1.4 NEK3 "HSPK36, MGC29949" ENSG00000136098 "NIMA related kinase 3" P51956 13 52132639-52159861 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Oligodendrocytes: 87.0;Spermatocytes: 49.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019062, HPA043230" Enhanced Approved Microtubules NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 5: NTERA-2 - Transcription" "Cluster 66: Spermatocytes - Spermatogenesis" Microtubules "HPA019062: AB_2670037, HPA043230: AB_2678374" "unprognostic (8.97e-2)" "unprognostic (2.54e-2)" "unprognostic (8.12e-2)" "unprognostic (1.84e-1)" "unprognostic (2.01e-2)" "unprognostic (2.05e-1)" "unprognostic (2.71e-1)" "unprognostic (2.31e-1)" "unprognostic (1.31e-1)" "unprognostic (4.30e-3)" "unprognostic (1.16e-3)" "unprognostic (1.70e-2)" "unprognostic (1.17e-3)" "unprognostic (1.22e-2)" "unprognostic (4.66e-2)" "unprognostic (4.15e-2)" "unprognostic (5.34e-2)" 12.4 3.8 13.7 6.2 18.5 8.6 10.6 12.5 21.8 10.8 11.2 16.2 9.3 9.9 6.9 4.2 8.7 7.4 7.8 12.9 14.2 10.1 7.3 9.0 5.0 18.2 17.8 8.2 8.3 3.8 5.2 17.4 17.3 8.2 16.8 4.7 7.0 5.0 6.0 7.2 12.7 8.6 12.9 8.0 6.7 18.1 19.9 3.2 6.3 3.3 5.4 8.3 7.4 26.3 0.3 2.7 20.2 11.4 6.2 10.8 0.3 6.5 6.2 7.6 8.3 8.6 11.1 0.0 0.4 8.4 6.3 1.5 0.4 4.8 4.8 15.1 11.8 1.9 2.7 23.0 7.6 19.4 10.9 7.2 9.5 4.2 17.6 5.6 13.5 1.0 3.1 7.1 9.0 5.1 1.1 23.4 19.7 4.4 0.5 0.5 1.7 7.6 11.4 1.9 2.2 14.0 2.9 6.4 12.8 19.6 2.5 26.3 12.2 1.0 5.9 6.0 6.7 7.5 2.5 13.1 1.8 6.8 10.8 7.1 6.3 5.1 1.6 5.8 1.0 3.6 1.9 1.0 6.7 1.9 1.4 0.4 0.4 1.6 1.2 5.8 2.9 1.4 13.7 18.5 12.5 21.8 12.9 14.2 18.2 17.8 17.3 12.9 19.9 26.3 28.8 6.4 6.5 9.1 5.9 2.8 4.4 2.8 5.7 3.9 5.5 6.7 7.7 5.7 5.8 7.3 0.0 13.0 8.3 20.1 13.7 7.9 11.5 9.8 14.0 22.7 6.0 3.4 0.6 17.3 14.4 8.7 10.2 11.0 10.1 11.6 18.2 7.4 19.1 3.3 3.4 13.7 6.1 12.4 8.1 4.6 7.2 10.4 12.4 18.7 25.4 3.0 7.2 9.0 87.0 15.6 17.9 6.8 6.0 3.3 22.4 6.8 7.1 5.8 0.0 7.1 9.0 49.7 25.5 3.5 3.4 4.8 4.0 3.9 20.1 5.2 NEK4 "NRK2, pp12301, STK2" ENSG00000114904 "NIMA related kinase 4" P51957 3 52708444-52770946 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 46.0" "Cell type enhanced" "Detected in all" "Spermatocytes: 75.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015750, HPA058543" Enhanced Supported Cytosol NA NA "Cluster 38: Basophils - Unknown function" "Cluster 1: Thyroid gland - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" Cytosol "HPA015750: AB_1854367, HPA058543: AB_2732623" "unprognostic (1.32e-1)" "unprognostic (1.57e-1)" "prognostic favorable (2.69e-5)" "unprognostic (9.65e-3)" "unprognostic (3.42e-1)" "unprognostic (6.64e-2)" "unprognostic (8.75e-3)" "unprognostic (2.27e-1)" "unprognostic (7.85e-2)" "unprognostic (5.52e-2)" "unprognostic (1.46e-1)" "unprognostic (1.32e-1)" "unprognostic (3.74e-3)" "unprognostic (5.11e-2)" "unprognostic (2.85e-1)" "unprognostic (1.51e-2)" "unprognostic (8.39e-2)" 6.3 8.2 6.1 7.4 6.7 7.0 9.4 9.1 7.4 8.5 8.6 7.3 6.5 8.7 8.9 6.7 13.6 6.2 6.1 5.9 7.8 9.7 10.8 6.7 8.3 6.8 8.9 13.3 8.1 11.5 7.3 7.6 6.3 7.7 8.2 16.9 7.3 9.0 8.0 3.5 5.6 8.1 6.9 7.2 9.6 46.0 7.8 9.5 13.5 6.1 9.4 7.9 4.9 5.9 19.9 15.2 20.5 16.2 18.2 13.1 22.1 13.9 18.6 25.3 25.4 13.5 14.4 20.4 6.4 13.6 27.9 9.2 25.2 16.3 33.8 20.4 10.6 16.0 18.4 17.3 11.4 39.4 15.4 8.1 14.8 32.5 21.5 13.5 9.6 17.4 20.2 16.1 16.1 17.1 21.4 14.4 17.7 20.9 14.9 18.5 17.8 15.1 14.3 28.3 15.0 9.0 29.1 17.7 14.1 15.7 16.5 23.4 8.9 16.9 17.1 27.3 26.0 17.8 27.9 19.7 19.3 18.2 18.7 13.6 9.8 5.0 3.5 6.1 3.7 2.8 3.0 3.6 5.2 3.5 3.6 3.1 1.4 4.0 4.2 2.6 2.6 5.2 6.1 6.7 9.1 7.4 5.9 7.8 6.8 8.9 6.3 6.9 7.8 5.9 6.2 12.8 8.2 19.2 11.8 4.1 5.3 3.4 4.6 14.1 10.6 6.2 4.6 2.8 11.6 5.5 12.5 7.0 4.8 6.5 9.8 7.0 20.7 24.0 10.6 7.3 4.8 13.3 30.5 9.6 8.1 7.8 12.8 9.9 7.6 14.0 6.8 14.5 8.2 6.7 29.4 9.3 6.1 16.8 4.6 19.5 14.6 10.4 1.8 7.5 14.0 19.4 10.3 16.6 19.3 8.5 2.9 12.4 10.6 5.3 5.4 17.1 22.4 18.9 6.6 12.6 7.3 75.9 27.9 6.9 4.1 6.7 5.8 11.8 9.1 5.2 NEK5 ENSG00000197168 "NIMA related kinase 5" Q6P3R8 13 52033611-52129092 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "brain: 5.1;choroid plexus: 7.4;fallopian tube: 8.8;testis: 10.8" "Group enriched" "Detected in many" 4 "Early spermatids: 57.9;Endometrial ciliated cells: 75.8;Late spermatids: 32.0;Respiratory ciliated cells: 98.6;Spermatocytes: 32.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "JURKAT: 1.2;OE19: 2.4;T-47d: 1.1" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA035565, HPA041399" Enhanced NA NA "Cluster 11: Basophils - Unknown function" "Cluster 49: Ciliated cells - Cilium organization" "Cluster 21: OE19 - Mitochondria" "Cluster 49: Ciliated cells - Cilium organization" "HPA035565: AB_10672095, HPA041399: AB_2677453" "unprognostic (4.14e-2)" "unprognostic (1.49e-1)" "unprognostic (1.89e-1)" "unprognostic (5.80e-3)" "unprognostic (2.80e-2)" "unprognostic (2.47e-1)" "unprognostic (3.57e-2)" "unprognostic (6.50e-2)" "unprognostic (8.82e-2)" "unprognostic (1.32e-1)" "unprognostic (1.37e-2)" "unprognostic (2.94e-1)" "unprognostic (2.06e-3)" "unprognostic (1.83e-3)" "unprognostic (1.10e-1)" "unprognostic (1.19e-3)" "unprognostic (9.44e-3)" 0.1 0.1 1.1 0.2 1.5 0.3 0.4 0.7 0.7 0.3 7.4 0.1 0.1 0.5 0.3 0.0 8.8 0.1 0.4 1.5 1.7 0.4 0.0 1.3 0.1 5.1 5.1 0.1 0.1 0.7 0.1 0.4 2.5 0.5 0.2 1.6 0.1 0.1 0.3 0.2 0.1 0.2 3.6 0.2 0.1 10.8 2.6 0.3 0.3 0.1 0.1 0.1 0.0 2.7 0.1 0.1 0.1 0.6 0.0 0.2 0.8 0.0 0.0 0.0 0.1 0.0 0.4 0.2 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.4 0.1 0.1 0.4 0.6 0.1 0.2 0.0 0.1 0.1 0.0 1.2 0.4 0.2 0.0 0.5 0.1 0.3 0.2 2.4 0.2 0.0 0.0 0.0 0.6 0.1 0.1 0.3 0.2 0.0 0.2 0.3 1.1 0.4 0.2 0.0 0.1 0.1 0.1 0.0 0.0 0.1 0.0 0.1 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 1.1 1.5 0.7 0.7 1.5 1.7 5.1 5.1 2.5 3.6 2.6 2.7 1.4 0.0 2.0 2.6 1.5 0.0 1.9 0.3 0.0 9.2 3.0 1.8 2.0 2.8 12.1 7.3 14.6 2.6 2.5 0.5 1.9 1.3 57.9 75.8 1.9 3.0 1.8 0.8 3.8 2.9 2.4 1.6 0.0 2.8 2.5 1.2 0.4 1.2 1.2 13.5 3.1 0.4 2.0 0.3 0.4 32.0 2.1 0.6 0.0 4.7 1.4 2.1 3.1 1.0 6.6 0.8 0.7 2.2 0.5 3.7 1.3 1.5 98.6 13.2 6.6 4.6 1.3 32.2 12.9 0.3 0.1 1.9 1.0 1.2 1.1 1.3 NEK6 SID6-1512 ENSG00000119408 "NIMA related kinase 6" Q9HC98 9 124257606-124353307 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Transporters" "Apoptosis, Cell cycle, Cell division, Chromosome partition, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 121.0;Hofbauer cells: 112.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HMC-1: 250.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB045993, HPA056828" Approved Supported "Nucleoplasm,Centriolar satellite,Cytosol" NA NA "Cluster 19: B-cells - Humoral immune response" "Cluster 15: Liver - Metabolism" "Cluster 3: HMC-1 - Innate immune response" "Cluster 38: Extravillous trophoblasts - Unknown function" "Nucleoplasm, Cytosol" "Centriolar satellite" "CAB045993: AB_2150651, HPA056828: AB_2683250" "unprognostic (6.27e-2)" "unprognostic (1.02e-2)" "unprognostic (4.15e-2)" "unprognostic (1.65e-2)" "unprognostic (5.22e-2)" "unprognostic (2.47e-2)" "unprognostic (3.13e-3)" "unprognostic (2.13e-2)" "unprognostic (2.38e-1)" "unprognostic (3.30e-2)" "unprognostic (1.38e-3)" "unprognostic (6.53e-2)" "unprognostic (5.03e-3)" "unprognostic (1.97e-1)" "prognostic unfavorable (7.66e-4)" "unprognostic (5.27e-2)" "unprognostic (4.77e-3)" 18.0 6.1 33.5 32.6 34.3 19.6 14.7 28.1 32.4 26.1 26.5 22.3 17.5 12.2 3.4 8.5 11.2 25.4 7.4 31.8 37.0 17.2 68.2 24.3 27.4 49.8 41.2 9.0 16.7 1.9 6.1 30.2 33.9 19.6 22.5 11.3 20.6 16.7 8.2 5.4 25.8 18.7 34.4 16.6 27.1 7.8 44.2 10.2 7.3 3.1 31.7 24.3 6.4 30.4 31.8 50.0 47.8 18.8 88.3 113.9 59.3 38.8 61.1 58.4 48.4 47.7 57.0 38.2 61.0 74.6 133.2 5.9 24.7 111.7 39.4 43.7 21.8 104.4 42.1 85.4 105.2 19.4 250.0 152.8 17.8 55.4 56.9 152.3 64.3 17.6 19.5 1.7 105.6 32.6 0.9 20.8 12.2 163.7 45.5 40.6 35.6 19.6 62.6 11.4 21.4 7.5 12.6 23.6 54.5 48.3 51.4 76.4 127.5 42.2 42.8 29.5 26.7 8.4 11.4 21.6 53.5 42.3 57.5 28.1 47.6 76.4 9.2 32.1 5.9 52.5 5.5 7.8 29.0 30.2 0.9 3.8 58.8 23.3 41.4 26.9 7.6 21.6 33.5 34.3 28.1 32.4 31.8 37.0 49.8 41.2 33.9 34.4 44.2 30.4 8.4 9.6 4.7 37.9 24.5 2.4 13.8 18.9 4.6 1.0 9.4 6.5 3.3 18.6 8.8 3.7 0.0 47.1 11.3 8.5 1.9 41.3 18.2 9.4 17.7 8.4 6.0 4.0 8.3 23.3 121.0 11.1 19.4 22.2 22.2 1.1 5.0 43.5 112.0 0.0 5.3 18.2 18.3 10.4 22.5 20.0 5.0 31.2 7.2 12.2 57.7 34.6 8.2 15.1 2.4 30.6 11.9 3.8 5.5 17.1 17.2 38.0 3.3 2.1 0.0 4.9 6.4 1.3 17.1 2.4 1.1 36.1 4.5 2.1 18.7 10.2 NEK7 ENSG00000151414 "NIMA related kinase 7" Q8TDX7 1 198156994-198322420 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Transporters" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 140.4" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 172.6;Oligodendrocyte precursor cells: 131.2;Oligodendrocytes: 153.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "BJ: 554.5;fHDF/TERT166: 753.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015520, HPA018193" Approved Supported Nucleoplasm Yes No "Cluster 16: MAIT-cells - Unknown function" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 54: Cardiomyocytes - Muscle contraction" Nucleoplasm "HPA015520: AB_1854371, HPA018193: AB_1854372" "unprognostic (2.08e-1)" "unprognostic (2.98e-2)" "unprognostic (1.65e-1)" "unprognostic (5.38e-2)" "unprognostic (4.26e-2)" "unprognostic (3.00e-2)" "unprognostic (2.14e-2)" "unprognostic (5.47e-2)" "unprognostic (4.77e-2)" "unprognostic (3.21e-1)" "unprognostic (1.46e-3)" "unprognostic (2.82e-1)" "unprognostic (1.13e-2)" "unprognostic (1.26e-2)" "unprognostic (1.74e-1)" "unprognostic (2.05e-2)" "unprognostic (1.56e-1)" 63.8 49.9 48.3 29.3 58.7 11.1 27.7 45.9 53.3 26.1 35.7 30.0 21.1 26.6 19.7 31.2 22.3 27.2 140.4 39.5 56.1 29.3 30.0 41.6 30.8 61.1 51.3 29.6 20.3 25.1 12.3 42.1 60.0 27.1 23.3 19.6 22.3 36.5 56.6 14.9 25.3 32.2 59.7 32.1 20.1 13.7 49.1 27.7 26.8 63.7 23.6 30.9 20.1 64.2 47.8 12.3 14.8 6.0 37.5 42.6 17.4 554.5 227.6 218.7 102.9 23.0 46.2 17.1 39.4 753.3 12.6 29.0 22.7 30.3 220.8 56.0 32.7 23.6 48.7 9.6 45.3 40.2 46.3 26.7 25.3 144.8 43.5 82.2 42.4 140.0 18.8 41.2 102.3 15.1 34.7 23.4 8.4 37.5 9.9 18.5 36.5 30.7 37.3 24.5 9.5 17.0 92.1 53.0 63.5 20.6 38.8 36.0 95.7 61.8 52.0 178.6 58.9 29.3 28.5 11.8 26.9 36.3 48.7 1.8 2.2 3.3 2.9 1.8 12.8 1.4 3.2 4.1 2.0 1.9 2.7 3.1 6.0 3.6 1.6 1.3 6.0 1.4 48.3 58.7 45.9 53.3 39.5 56.1 61.1 51.3 60.0 59.7 49.1 64.2 34.3 28.9 30.7 78.0 32.4 51.4 15.0 10.2 33.6 8.2 22.8 18.2 172.6 10.0 18.7 18.4 14.6 15.0 32.9 25.8 11.7 10.6 2.8 21.6 20.9 29.3 19.8 32.6 17.0 19.6 15.9 30.0 18.8 19.6 8.8 11.8 40.4 23.5 17.5 3.3 34.6 19.5 8.2 49.5 51.6 3.3 29.2 35.5 30.2 124.6 29.0 11.4 15.5 131.2 153.5 50.1 19.3 38.4 28.5 30.6 25.1 16.6 27.9 24.2 19.7 28.1 35.9 7.7 6.0 29.2 49.2 64.3 41.6 28.7 15.6 33.1 NEK8 NPHP9 ENSG00000160602 "NIMA related kinase 8" Q86SG6 17 28725897-28743455 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Ciliopathy, Disease variant, Nephronophthisis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "plasmacytoid DC: 14.8" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA040661, HPA040679" Approved Approved "Nuclear speckles,Microtubules,Mitotic spindle" Yes NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 7: Kidney - Transmembrane transport" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Microtubules "Nuclear speckles, Mitotic spindle" "HPA040661: AB_10794065, HPA040679: AB_10796226" "unprognostic (2.63e-1)" "unprognostic (4.57e-2)" "prognostic unfavorable (6.98e-4)" "unprognostic (6.25e-2)" "unprognostic (2.23e-2)" "unprognostic (5.93e-3)" "unprognostic (6.48e-2)" "prognostic favorable (4.52e-4)" "unprognostic (7.85e-2)" "unprognostic (1.37e-1)" "unprognostic (1.51e-3)" "unprognostic (1.55e-1)" "unprognostic (4.87e-3)" "unprognostic (4.61e-2)" "unprognostic (3.58e-1)" "unprognostic (1.75e-1)" "unprognostic (4.67e-3)" 1.5 3.1 1.7 3.3 1.9 1.7 2.4 1.4 1.9 2.5 3.8 2.4 3.0 1.5 3.2 2.5 3.9 2.0 1.0 1.4 1.6 9.1 5.2 3.3 5.8 2.0 1.7 1.9 4.5 2.9 4.4 2.6 1.7 4.0 2.2 0.6 3.7 2.6 0.5 3.1 4.2 1.2 1.6 5.8 3.4 3.8 1.9 2.7 7.2 0.4 5.0 2.6 2.2 2.3 2.1 3.4 3.5 2.8 1.9 2.1 10.9 0.9 2.1 1.3 1.7 5.4 5.0 13.1 3.5 2.8 2.5 3.8 5.2 4.8 1.3 3.5 6.4 2.9 5.8 10.1 3.3 1.8 3.7 4.8 1.8 2.5 5.8 1.8 0.9 1.9 4.3 1.3 1.5 4.7 1.9 3.4 3.3 3.7 1.0 4.9 2.3 5.9 7.0 5.7 6.4 1.5 3.0 6.3 1.6 4.7 9.3 2.4 0.8 1.3 2.2 1.6 1.0 1.5 1.8 8.9 2.0 1.6 3.1 3.3 0.9 1.2 0.7 0.5 0.8 2.8 0.6 0.7 0.1 4.2 0.7 1.0 0.4 1.3 1.1 14.8 0.5 0.8 1.7 1.9 1.4 1.9 1.4 1.6 2.0 1.7 1.7 1.6 1.9 2.3 2.7 9.6 19.3 3.9 22.9 2.8 9.2 8.3 7.4 2.8 10.1 14.1 1.7 12.8 11.6 25.8 8.4 17.6 19.1 14.9 7.9 5.8 9.5 12.8 6.0 2.9 10.3 7.0 0.7 6.0 9.2 3.9 6.1 15.2 26.6 3.2 3.3 9.4 3.9 1.7 0.5 14.4 10.2 5.0 2.7 2.0 3.4 4.4 3.6 2.8 4.0 2.6 3.1 1.5 1.6 3.9 17.2 2.6 7.2 8.6 13.4 4.3 14.3 1.8 0.0 11.7 3.0 19.9 11.4 8.8 1.6 11.1 4.9 7.8 15.9 4.2 NEK9 "DKFZp434D0935, MGC16714, Nek8, NERCC, NERCC1" ENSG00000119638 "NIMA related kinase 9" Q8TD19 14 75079353-75127344 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001405 Approved NA NA "Cluster 44: Non-specific - Transcription" "Cluster 52: Non-specific - Ribosome" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 59: Non-specific - Transcription" "HPA001405: AB_1079467" "unprognostic (1.00e-1)" "unprognostic (5.37e-2)" "unprognostic (9.97e-3)" "unprognostic (2.64e-2)" "unprognostic (3.86e-1)" "unprognostic (2.77e-1)" "unprognostic (1.12e-1)" "unprognostic (5.60e-3)" "unprognostic (2.81e-1)" "unprognostic (1.15e-1)" "prognostic favorable (5.63e-4)" "unprognostic (8.58e-2)" "unprognostic (1.36e-2)" "unprognostic (4.54e-2)" "unprognostic (9.22e-2)" "unprognostic (2.61e-1)" "unprognostic (1.57e-2)" 24.2 18.5 6.7 18.6 8.4 11.8 17.3 7.5 7.9 24.3 9.0 14.3 15.5 26.0 10.5 17.8 25.2 17.9 37.2 6.1 7.8 18.4 21.0 18.8 21.0 8.2 7.7 35.8 16.0 34.2 3.1 21.2 7.9 23.5 16.3 16.5 12.4 28.1 43.6 8.1 16.9 32.2 7.5 19.7 13.1 20.4 7.7 28.3 19.7 36.9 23.5 16.3 2.9 9.1 21.3 30.8 44.8 45.4 86.3 88.8 37.9 32.4 54.6 29.7 29.4 25.5 24.7 52.7 0.1 54.2 23.1 31.8 45.0 27.0 38.5 38.2 16.8 23.0 27.3 17.3 48.6 10.8 26.8 76.6 32.8 31.8 26.7 71.6 46.1 36.2 23.8 31.4 40.2 4.8 35.5 11.5 21.9 43.3 18.8 53.5 49.4 23.9 21.3 28.2 19.5 41.3 39.5 19.3 30.0 50.4 41.7 37.6 46.3 30.2 12.7 31.5 15.8 34.3 36.5 49.6 24.9 24.8 26.4 3.4 3.5 3.1 2.5 3.4 4.0 1.3 2.4 2.3 5.0 1.9 3.1 2.8 1.2 3.3 2.5 1.1 1.5 2.9 6.7 8.4 7.5 7.9 6.1 7.8 8.2 7.7 7.9 7.5 7.7 9.1 15.3 12.8 30.2 49.3 21.2 8.8 7.7 6.6 21.1 16.8 14.5 12.4 55.7 12.8 14.8 11.0 35.5 17.4 11.1 10.2 7.9 6.9 11.9 13.3 23.1 17.6 5.4 16.2 31.3 4.9 16.2 18.1 10.7 10.4 16.4 36.8 17.9 30.3 13.9 13.5 35.9 10.7 6.1 18.6 11.8 8.3 24.8 17.0 3.6 30.9 16.0 12.0 15.5 41.2 59.5 5.3 11.7 26.4 14.7 7.4 13.1 8.4 17.4 23.1 0.0 18.9 16.7 28.8 13.9 17.4 10.2 14.0 16.5 20.8 10.5 5.6 NEURL1 "h-neu, neu-1, NEURL, RNF67" ENSG00000107954 "Neuralized E3 ubiquitin protein ligase 1" O76050 10 103493979-103592552 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Notch signaling pathway, Translation regulation, Ubl conjugation pathway" Transferase "Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 146.9;tongue: 60.5" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 93.8;Early spermatids: 128.7;Intestinal goblet cells: 105.4;Late spermatids: 461.2;Paneth cells: 183.4;Syncytiotrophoblasts: 113.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Group enriched" "Detected in many" 13 "intermediate monocyte: 45.1;non-classical monocyte: 112.0" "Lineage enriched" "Detected in many" 19 "monocytes: 112.0" "Cell line enhanced" "Detected in some" "BEWO: 13.7;HeLa: 8.6;HMC-1: 6.9;JURKAT: 7.4;SCLC-21H: 17.1;SiHa: 8.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044204 Enhanced NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 80: Striated muscle - Unknown function" "Cluster 28: BEWO - Transcription regulation" "Cluster 25: Spermatids - Spermatogenesis" "HPA044204: AB_10959383" "unprognostic (1.21e-2)" "unprognostic (8.14e-2)" "unprognostic (1.18e-3)" "unprognostic (1.58e-4)" "unprognostic (1.31e-2)" "unprognostic (2.60e-1)" "unprognostic (5.24e-2)" "unprognostic (2.54e-1)" "unprognostic (1.37e-1)" "unprognostic (4.31e-2)" "unprognostic (1.32e-3)" "unprognostic (1.08e-1)" "unprognostic (8.61e-3)" "unprognostic (1.59e-1)" "unprognostic (1.44e-1)" "unprognostic (2.91e-4)" "unprognostic (3.23e-1)" 0.5 4.6 25.5 3.8 29.6 2.2 0.4 20.8 37.4 14.1 0.0 15.2 10.9 25.8 15.1 4.3 2.6 1.9 0.5 32.2 7.2 2.4 1.2 0.9 0.8 1.7 4.1 1.9 18.8 8.3 15.9 4.6 1.3 1.4 10.3 39.5 2.9 1.3 146.9 1.8 17.2 5.2 0.0 1.9 5.2 13.0 5.0 1.1 0.5 60.5 0.5 18.7 2.6 17.2 0.9 0.2 1.3 0.0 0.2 0.1 13.7 0.5 0.9 0.2 0.1 0.3 0.2 0.4 0.7 0.1 0.9 0.6 0.4 0.2 0.1 0.4 0.8 0.2 8.6 0.3 0.0 0.3 6.9 0.2 0.5 0.1 0.7 0.2 0.0 7.4 2.3 0.5 0.2 1.2 1.4 0.9 0.0 0.5 4.2 0.2 0.7 1.5 0.0 0.5 17.1 5.9 8.8 0.0 0.4 2.5 0.7 1.7 0.0 0.1 0.9 0.3 0.2 1.0 0.2 0.3 0.5 0.0 0.4 0.8 2.8 0.5 0.7 45.1 1.1 1.1 1.0 1.1 5.8 0.7 1.2 0.8 2.3 0.6 112.0 4.7 0.4 4.1 25.5 29.6 20.8 37.4 32.2 7.2 1.7 4.1 1.3 0.0 5.0 17.2 0.3 0.0 0.6 1.3 1.5 0.5 1.5 0.2 0.0 53.2 2.0 2.7 1.6 0.0 0.2 0.0 93.8 4.6 3.1 7.9 0.0 12.0 128.7 0.0 0.8 2.2 78.3 4.6 47.9 0.7 12.9 2.2 13.3 0.1 0.0 1.2 0.0 0.2 4.5 3.3 32.9 105.4 32.6 4.6 2.4 461.2 5.6 4.8 0.0 0.0 5.5 9.0 2.1 1.0 4.2 0.5 183.4 5.3 0.6 1.3 7.2 0.0 0.2 88.0 6.6 2.4 1.0 56.6 33.6 0.0 1.8 113.4 1.7 8.4 9.4 0.7 NEURL1B "DKFZP761M1511, Neur2, RNF67B" ENSG00000214357 "Neuralized E3 ubiquitin protein ligase 1B" A8MQ27 5 172641263-172691540 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Notch signaling pathway, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Adipocytes: 82.8;Distal enterocytes: 82.5;Endothelial cells: 53.8;Leydig cells: 54.7;Paneth cells: 42.1;Proximal enterocytes: 53.4;Smooth muscle cells: 58.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "REH: 43.7;T-47d: 20.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA037612 Approved Supported "Actin filaments,Cytosol" NA Yes "Cluster 46: Fibroblasts - ECM organization" "Cluster 14: REH - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "Actin filaments" "HPA037612: AB_10795573" "unprognostic (3.56e-2)" "unprognostic (8.46e-2)" "unprognostic (6.72e-3)" "unprognostic (2.70e-1)" "unprognostic (1.64e-1)" "unprognostic (1.55e-1)" "unprognostic (6.58e-2)" "unprognostic (2.95e-1)" "unprognostic (2.86e-1)" "unprognostic (1.09e-1)" "unprognostic (7.13e-3)" "unprognostic (6.81e-2)" "prognostic unfavorable (3.00e-6)" "unprognostic (1.79e-1)" "unprognostic (1.40e-1)" "unprognostic (4.67e-2)" "unprognostic (3.22e-3)" 25.0 16.0 8.4 5.2 10.3 2.0 21.1 2.3 24.1 18.3 3.4 28.4 6.9 24.7 24.1 13.5 22.0 11.7 32.2 17.1 6.9 11.0 6.0 12.6 3.7 3.5 4.6 14.7 5.3 3.2 8.2 6.1 3.8 17.6 13.7 0.3 6.6 32.1 14.0 18.1 17.6 20.4 3.6 0.7 7.7 4.3 6.3 5.9 10.3 16.0 3.9 25.7 17.3 6.5 7.2 3.7 2.0 8.9 0.6 0.3 0.1 8.0 3.5 4.1 6.0 13.7 3.2 0.0 2.1 5.2 5.0 2.1 0.7 3.6 2.8 13.2 0.5 9.8 13.3 0.1 0.6 0.0 2.9 0.0 15.1 0.9 4.1 1.2 0.6 1.4 0.0 3.0 8.9 8.0 2.3 0.2 1.3 3.1 0.3 43.7 9.4 1.4 0.1 1.6 1.6 8.9 7.6 11.9 0.3 3.5 20.0 1.5 1.3 3.1 18.1 2.2 5.1 1.2 0.4 0.0 9.0 0.2 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.4 10.3 2.3 24.1 17.1 6.9 3.5 4.6 3.8 3.6 6.3 6.5 82.8 0.0 1.9 0.3 0.6 4.8 0.7 3.0 0.6 0.6 1.5 1.3 9.3 1.5 4.8 0.0 0.0 0.3 0.4 82.5 0.0 0.7 2.6 1.9 2.5 53.8 13.9 11.4 5.2 0.7 0.2 10.3 2.0 0.6 0.0 4.9 30.4 0.3 0.3 0.0 1.0 10.2 2.0 1.9 2.6 6.6 54.7 2.2 7.2 4.7 0.7 0.7 0.0 5.0 13.0 4.5 42.1 12.4 0.1 1.9 53.4 0.8 12.8 0.3 26.3 11.6 58.8 2.5 3.4 7.7 5.4 0.1 0.7 2.5 20.0 1.2 NEURL3 "Lincr, LOC93082, RNF132" ENSG00000163121 "Neuralized E3 ubiquitin protein ligase 3" Q96EH8 2 96497646-96508109 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "kidney: 16.2;pancreas: 25.1;salivary gland: 30.3" "Group enriched" "Detected in many" 4 "Ductal cells: 114.6;Exocrine glandular cells: 36.5" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 3.8;CAPAN-2: 15.6;GAMG: 5.5;RPMI-8226: 10.1;RT4: 4.7" "Low region specificity" "Detected in some" "Not detected" "Not detected" NA NA "Cluster 25: Pancreas - Digestion" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 1: Pancreatic cells - Digestion" "unprognostic (4.97e-2)" "unprognostic (6.07e-2)" "unprognostic (7.22e-2)" "unprognostic (1.42e-2)" "unprognostic (2.49e-2)" "unprognostic (4.35e-2)" "prognostic unfavorable (6.46e-4)" "unprognostic (2.29e-1)" "unprognostic (9.55e-2)" "unprognostic (1.18e-2)" "unprognostic (1.06e-1)" "unprognostic (8.14e-3)" "unprognostic (1.23e-2)" "unprognostic (5.83e-2)" "unprognostic (6.57e-2)" "unprognostic (2.44e-1)" "unprognostic (6.57e-4)" 0.1 0.0 0.8 0.4 0.8 0.3 1.9 0.6 0.9 0.1 0.5 0.7 1.6 0.1 0.1 0.1 0.2 2.1 0.2 0.8 0.7 16.2 2.5 2.5 0.2 0.8 0.7 0.0 25.1 0.0 0.3 0.0 0.8 3.9 0.5 0.1 30.3 2.5 0.1 0.6 2.1 0.0 0.7 0.6 0.5 0.4 0.7 4.8 0.0 0.0 0.3 0.4 0.0 0.9 1.0 0.5 0.0 0.3 0.0 0.0 3.8 0.0 0.4 0.3 0.2 2.3 15.6 0.0 1.2 0.0 5.5 2.3 0.2 0.0 0.0 0.6 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.9 0.4 0.0 0.0 10.1 2.1 4.7 0.0 0.0 0.0 1.9 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.1 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.5 0.8 0.8 0.6 0.9 0.8 0.7 0.8 0.7 0.8 0.7 0.7 0.9 0.4 0.0 1.5 0.7 0.9 0.0 10.2 0.0 0.0 0.0 7.6 8.3 0.4 11.5 0.6 9.2 0.0 0.3 0.3 6.9 3.9 114.6 0.0 4.9 0.2 1.0 2.4 3.2 0.4 36.5 0.0 0.2 0.0 0.8 0.0 0.1 0.0 0.2 1.1 0.0 0.1 1.4 0.0 0.0 0.0 0.1 0.0 0.7 0.0 0.0 12.2 0.8 0.0 0.0 0.1 17.8 5.2 0.0 0.0 13.2 10.6 5.8 0.0 0.0 0.0 0.0 0.4 0.7 1.9 0.0 0.0 0.0 0.2 1.4 1.2 5.9 NFS1 "IscS, NifS" ENSG00000244005 "NFS1 cysteine desulfurase" Q9Y697 20 35668052-35699355 "Enzymes, Predicted intracellular proteins" "Molybdenum cofactor biosynthesis" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Proximal tubular cells: 56.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB034314, HPA051801, HPA054755" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 15: NK-cells - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 39: CACO-2 - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Nucleoplasm, Cytosol" "CAB034314: AB_2235980, HPA051801: AB_2681616, HPA054755: AB_2682594" "unprognostic (1.72e-1)" "unprognostic (2.96e-1)" "unprognostic (1.27e-2)" "unprognostic (5.88e-3)" "unprognostic (1.05e-1)" "unprognostic (4.33e-2)" "unprognostic (1.14e-1)" "unprognostic (2.02e-1)" "unprognostic (9.00e-2)" "unprognostic (1.73e-1)" "unprognostic (6.52e-3)" "unprognostic (3.93e-2)" "prognostic favorable (4.72e-6)" "unprognostic (2.33e-2)" "unprognostic (1.97e-1)" "unprognostic (1.64e-2)" "unprognostic (5.54e-2)" 12.0 28.7 17.8 7.7 19.0 4.5 10.6 19.5 20.4 11.6 19.0 13.1 12.4 9.1 10.3 11.0 12.5 8.5 22.6 18.2 20.0 42.2 37.7 6.8 8.6 17.4 17.7 13.1 11.9 25.9 12.3 8.6 19.8 9.9 14.1 17.1 13.5 12.6 25.3 10.6 11.1 11.0 17.3 7.7 12.1 19.0 19.6 9.3 10.7 36.5 12.1 9.7 9.1 19.4 29.6 36.0 12.3 13.0 32.7 29.9 24.9 21.9 23.1 32.2 20.9 65.4 16.3 25.1 42.1 20.6 33.3 36.3 42.6 44.5 29.3 11.3 20.0 53.7 37.6 51.4 27.1 22.9 9.9 24.2 41.6 25.5 27.9 24.1 24.6 29.0 38.9 16.3 23.1 45.3 25.8 24.0 14.3 67.1 53.3 10.1 39.9 42.2 33.0 19.6 15.4 14.1 54.9 52.3 36.9 28.6 46.9 20.1 18.2 36.4 17.4 21.6 21.9 23.5 34.3 22.6 30.9 24.2 18.5 3.0 6.8 6.5 5.8 6.7 7.7 8.4 6.7 8.9 9.4 5.6 7.8 7.2 2.7 10.6 5.2 4.5 9.6 5.5 17.8 19.0 19.5 20.4 18.2 20.0 17.4 17.7 19.8 17.3 19.6 19.4 9.7 6.4 15.0 9.4 8.0 6.1 8.1 16.7 6.2 14.9 11.7 10.3 20.6 21.5 10.4 18.4 10.4 35.2 5.4 12.3 33.2 15.9 6.0 7.2 8.5 6.9 6.7 13.9 9.0 11.2 22.5 10.7 11.2 8.8 7.0 8.7 6.8 26.8 16.1 15.2 9.9 7.0 16.2 8.9 4.8 4.4 5.6 7.0 10.6 6.5 12.3 15.2 5.2 4.5 12.6 10.9 11.0 10.5 5.8 5.6 17.3 56.6 7.6 13.5 13.1 8.6 9.1 50.7 19.7 9.1 5.7 21.1 7.4 25.4 14.8 7.9 NHLRC1 "bA204B7.2, EPM2B" ENSG00000187566 "NHL repeat containing E3 ubiquitin protein ligase 1" Q6VVB1 6 18120440-18122677 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Autophagy, Ubl conjugation pathway" Transferase "Disease variant, Epilepsy, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Erythroid cells: 5.0;Exocrine glandular cells: 3.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "EFO-21: 6.8;K-562: 6.1;SCLC-21H: 6.1" "Low region specificity" "Detected in all" HPA066030 Uncertain Vesicles NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 15: Liver - Metabolism" "Cluster 1: K-562 - Erythropoiesis" "Cluster 4: Macrophages - Innate immune response" Vesicles "HPA066030: " "unprognostic (1.61e-1)" "unprognostic (1.39e-1)" "unprognostic (7.95e-2)" "prognostic unfavorable (9.01e-4)" "unprognostic (6.95e-3)" "unprognostic (2.45e-1)" "unprognostic (1.09e-1)" "unprognostic (3.69e-1)" "unprognostic (2.39e-1)" "unprognostic (7.17e-2)" "unprognostic (5.07e-3)" "unprognostic (1.28e-1)" "unprognostic (2.32e-2)" "unprognostic (3.19e-1)" "unprognostic (2.33e-1)" "unprognostic (2.77e-2)" "prognostic favorable (5.30e-4)" 1.2 1.4 2.0 0.8 2.3 1.1 2.0 1.5 2.6 0.8 0.8 1.5 1.4 0.8 2.6 1.1 1.4 0.6 1.8 2.4 1.9 0.8 4.1 1.2 0.6 2.5 1.8 1.4 1.8 1.2 1.2 0.5 2.7 1.2 1.3 2.0 2.3 1.0 2.6 3.8 1.9 0.8 1.6 1.1 1.3 0.7 2.0 1.0 1.6 1.5 0.8 0.9 0.8 3.6 2.6 1.5 0.6 0.0 1.3 1.2 0.0 2.6 0.8 0.9 0.5 0.1 2.1 0.0 6.8 1.9 0.2 3.0 0.0 1.7 0.7 0.1 0.9 0.4 1.0 0.1 2.0 0.0 1.7 2.1 2.5 1.0 0.9 0.6 2.1 0.0 6.1 0.1 2.1 2.8 0.0 0.0 0.0 0.3 1.5 0.0 0.0 0.1 1.4 2.8 6.1 0.1 5.3 4.3 1.6 0.6 3.1 1.7 0.4 0.2 1.3 1.8 0.1 0.1 0.0 0.1 0.1 0.0 2.6 0.5 4.4 0.4 0.6 4.9 0.8 2.3 1.1 0.5 4.7 1.3 1.5 1.0 0.3 1.6 2.3 0.6 1.3 1.8 2.0 2.3 1.5 2.6 2.4 1.9 2.5 1.8 2.7 1.6 2.0 3.6 0.8 0.0 2.2 0.3 0.2 1.9 1.4 1.4 1.8 0.4 1.5 2.0 0.9 1.5 2.3 0.0 0.0 0.4 0.0 0.2 0.0 2.9 0.0 0.6 1.3 0.3 3.5 5.0 1.0 3.7 0.0 0.8 1.5 0.5 1.3 0.8 0.4 1.1 1.2 0.0 0.7 0.3 0.0 0.8 0.6 0.0 0.6 1.5 1.8 1.0 0.5 1.1 0.0 1.5 1.2 2.0 0.3 0.0 0.0 0.2 0.6 1.2 0.8 1.0 0.0 0.3 0.8 0.2 0.2 1.3 1.8 0.4 0.1 1.1 0.5 0.5 NIM1K "MGC42105, NIM1" ENSG00000177453 "NIM1 serine/threonine protein kinase" Q8IY84 5 43192071-43280850 "Enzymes, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "brain: 13.7;choroid plexus: 7.9;pituitary gland: 6.5;retina: 10.3" "Cell type enhanced" "Detected in some" "Astrocytes: 29.7;Excitatory neurons: 56.0;Horizontal cells: 18.5;Inhibitory neurons: 44.2;Oligodendrocyte precursor cells: 43.7;Oligodendrocytes: 20.3" "Cancer enriched" "Detected in some" 11 "glioma: 6.2" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BJ hTERT+ SV40 Large T+ RasG12V: 2.0;HDLM-2: 2.3;PC-3: 2.5;U-87 MG: 2.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007695 Approved Cytosol NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 77: Retina - Visual perception" "Cluster 44: HDLM-2 - Immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol "HPA007695: AB_2667897" "unprognostic (7.97e-2)" "unprognostic (9.79e-2)" "unprognostic (8.74e-2)" "unprognostic (2.10e-1)" "unprognostic (1.67e-1)" "unprognostic (2.17e-1)" "unprognostic (2.40e-1)" "unprognostic (4.35e-2)" "unprognostic (1.35e-1)" "unprognostic (4.28e-2)" "unprognostic (8.84e-4)" "unprognostic (1.25e-1)" "unprognostic (1.55e-5)" "unprognostic (2.18e-1)" "unprognostic (2.66e-1)" "unprognostic (6.46e-3)" "unprognostic (4.98e-3)" 0.4 1.2 11.9 0.4 12.5 0.0 0.4 8.9 13.7 0.9 7.9 1.6 0.1 0.2 0.3 0.4 0.5 0.3 0.8 12.5 11.6 0.3 0.3 1.3 0.2 9.9 10.8 0.2 0.3 1.2 6.5 0.4 9.5 0.8 0.4 10.3 0.8 0.6 0.8 0.6 0.5 0.2 10.4 0.2 1.2 0.4 11.3 0.2 0.9 0.6 0.1 0.6 0.8 11.7 0.1 0.2 0.0 0.0 0.4 0.2 0.0 0.4 1.5 0.5 2.0 0.0 0.0 0.2 0.2 0.4 0.7 0.1 0.3 0.0 1.2 2.3 0.1 0.0 0.3 0.0 0.7 0.1 0.3 0.8 0.0 0.2 0.0 0.7 0.0 0.0 0.1 0.1 0.4 0.1 0.1 0.1 0.0 0.0 2.5 0.1 0.1 0.2 0.0 0.3 0.4 0.0 0.8 0.2 0.1 0.1 0.2 0.7 0.0 0.4 0.3 0.3 0.3 0.7 0.2 0.1 2.7 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.8 0.0 11.9 12.5 8.9 13.7 12.5 11.6 9.9 10.8 9.5 10.4 11.3 11.7 0.4 0.0 4.4 29.7 0.0 0.5 0.1 0.4 1.8 7.6 0.1 0.0 0.3 0.0 0.1 0.0 6.2 0.1 0.1 0.0 0.0 0.0 1.3 0.0 1.0 0.2 0.0 0.0 56.0 0.0 1.4 1.0 0.5 0.3 0.0 0.1 0.0 0.1 0.1 18.5 44.2 0.0 0.0 0.3 0.0 1.8 0.0 0.2 0.0 1.0 0.6 9.9 0.0 43.7 20.3 0.1 0.0 0.7 0.0 0.1 0.0 0.0 0.0 6.6 0.0 1.2 0.6 0.4 0.4 0.2 0.4 0.0 0.4 0.4 0.0 0.1 NLK ENSG00000087095 "Nemo like kinase" Q9UBE8 17 28041737-28196381 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation, Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "retina: 78.6" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 154.3;Early spermatids: 261.1;Excitatory neurons: 315.5;Late spermatids: 355.3;Oligodendrocytes: 366.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 45 "basophil: 29.9" "Lineage enriched" "Detected in single" 45 "granulocytes: 29.9" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018192, HPA056511" Approved Approved "Nucleoplasm,Nucleoli,Cell Junctions" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 58: Brain - Synaptic function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "Nucleoli, Cell Junctions" "HPA018192: AB_1854525, HPA056511: AB_2683160" "unprognostic (7.19e-2)" "unprognostic (1.98e-1)" "unprognostic (5.54e-2)" "unprognostic (5.64e-3)" "unprognostic (2.11e-1)" "unprognostic (1.29e-1)" "unprognostic (1.67e-2)" "unprognostic (2.59e-3)" "unprognostic (2.72e-2)" "unprognostic (4.23e-3)" "unprognostic (1.07e-2)" "unprognostic (1.09e-2)" "unprognostic (5.29e-2)" "unprognostic (1.66e-1)" "unprognostic (3.92e-1)" "unprognostic (5.27e-2)" "unprognostic (6.57e-2)" 8.2 36.6 16.7 8.6 27.6 9.9 9.4 5.7 41.9 7.9 1.0 9.0 10.3 7.0 11.2 5.5 6.4 8.7 11.5 28.5 9.2 16.6 11.1 9.1 16.4 11.9 10.4 5.0 14.3 28.2 11.1 12.2 8.4 8.2 9.2 78.6 7.4 10.8 6.6 5.9 10.2 5.9 6.5 12.2 8.9 22.0 12.2 13.2 16.8 6.7 15.4 10.1 4.5 30.1 9.5 11.6 28.4 9.7 6.1 7.6 12.1 9.6 10.9 16.9 13.1 59.4 9.1 13.6 13.8 8.4 20.2 8.6 19.6 18.7 19.3 29.7 12.2 52.2 11.2 9.9 10.3 11.6 51.0 9.6 11.9 10.4 12.5 16.0 20.4 36.3 20.1 15.9 16.4 11.6 28.8 13.4 10.4 20.1 5.5 23.8 17.2 10.0 32.0 12.2 19.6 7.2 14.4 14.4 62.4 32.2 22.0 18.2 19.2 11.7 14.1 9.0 19.5 17.6 17.9 13.1 11.6 12.6 13.0 29.9 0.3 0.3 0.5 0.4 0.2 0.6 0.5 0.6 0.3 0.3 0.3 0.6 0.2 0.2 0.5 0.5 0.5 0.3 16.7 27.6 5.7 41.9 28.5 9.2 11.9 10.4 8.4 6.5 12.2 30.1 17.8 22.4 6.0 57.8 7.8 5.4 3.8 3.0 5.7 94.4 8.7 5.0 27.4 5.7 5.3 33.1 154.3 3.7 4.3 11.4 1.9 3.9 261.1 8.9 5.8 15.0 28.2 11.8 315.5 6.4 3.5 4.8 5.1 11.9 24.1 17.6 9.3 9.4 8.8 37.0 98.2 10.0 2.0 16.9 6.0 355.3 5.6 11.3 16.0 103.0 7.9 11.2 6.2 104.5 366.6 5.7 8.1 2.6 6.4 5.4 5.1 8.4 9.5 89.9 13.1 5.0 6.9 37.1 11.8 4.1 4.8 6.4 5.5 6.7 10.3 6.6 NME1 "NDPKA, NM23, NM23-H1" ENSG00000239672 "NME/NM23 nucleoside diphosphate kinase 1" P15531 17 51153559-51162428 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Differentiation, Endocytosis, Neurogenesis, Nucleotide metabolism" "Kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008467, CAB040571, HPA041113" Supported Supported "Nucleoplasm,Plasma membrane,Cytosol" "Intracellular and membrane" NA NA 21000000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 77: Retina - Visual perception" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Cytosol "Nucleoplasm, Plasma membrane" "CAB040571: , HPA008467: AB_1079492, HPA041113: AB_2677305" "unprognostic (2.24e-1)" "unprognostic (2.01e-1)" "unprognostic (3.48e-3)" "unprognostic (5.96e-2)" "unprognostic (9.71e-2)" "unprognostic (2.33e-3)" "prognostic unfavorable (2.60e-5)" "unprognostic (4.54e-2)" "unprognostic (3.35e-1)" "unprognostic (2.33e-3)" "unprognostic (2.90e-2)" "unprognostic (1.01e-1)" "prognostic unfavorable (2.07e-9)" "unprognostic (9.01e-2)" "unprognostic (1.51e-1)" "unprognostic (1.83e-1)" "unprognostic (9.46e-2)" 63.6 84.4 79.3 74.7 81.6 77.0 63.1 78.7 102.2 38.2 79.0 60.1 38.8 49.7 46.8 91.0 48.6 20.8 37.7 88.0 92.0 65.4 83.2 41.3 73.9 83.9 78.4 33.6 67.8 52.8 47.4 39.2 82.4 38.7 77.6 218.4 50.7 30.4 35.6 57.5 33.1 66.3 76.5 48.5 41.8 25.3 81.0 61.1 41.3 20.9 95.8 72.2 48.9 80.1 483.6 833.1 285.9 444.8 118.6 183.7 479.7 355.3 227.3 652.2 489.7 656.9 288.1 754.2 372.4 304.1 272.4 252.1 542.5 553.3 553.4 398.4 729.3 504.9 605.8 975.9 237.1 575.8 243.8 177.8 341.7 493.1 458.6 120.6 404.6 247.8 739.0 270.0 392.8 720.4 715.2 647.1 390.7 957.5 739.3 446.9 587.6 751.3 511.5 320.2 418.6 461.1 188.1 521.0 385.3 246.2 554.0 419.6 279.5 476.9 452.2 307.0 774.4 374.0 840.9 956.3 286.2 480.4 385.8 1.1 55.0 2.1 47.2 77.1 69.3 96.4 50.3 53.8 134.0 67.6 54.3 60.4 1.7 69.6 48.6 84.8 49.1 68.4 79.3 81.6 78.7 102.2 88.0 92.0 83.9 78.4 82.4 76.5 81.0 80.1 53.1 32.1 30.5 0.0 71.3 132.4 97.5 198.8 88.8 283.3 98.8 118.1 34.2 65.8 92.3 71.7 285.7 180.0 25.4 54.2 150.6 211.3 34.2 40.2 107.2 85.1 89.7 81.8 0.0 201.5 269.7 85.0 64.2 37.2 45.7 113.5 27.8 123.3 207.1 40.4 0.0 107.4 101.7 25.7 88.9 93.7 61.2 48.9 129.9 0.0 47.2 105.6 27.8 0.0 0.0 194.0 50.5 58.6 113.8 170.6 12.2 195.2 42.0 323.7 13.1 83.0 182.9 22.7 98.8 139.4 133.1 88.5 38.0 215.5 157.7 98.2 NME2 "NDPKB, NM23-H2" ENSG00000243678 "NME/NM23 nucleoside diphosphate kinase 2" P22392 17 51165435-51171744 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Nucleotide metabolism, Transcription, Transcription regulation" "Activator, DNA-binding, Kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 918.0;Gastric mucus-secreting cells: 438.3;Plasma cells: 778.5;Squamous epithelial cells: 1490.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected" "Not detected" "CAB036213, CAB036214, CAB036215, HPA041113" Approved Supported "Plasma membrane,Midbody ring,Cytosol" Yes NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 50: Non-specific - Ribosome" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 61: Squamous epithelial cells - Keratinization" Cytosol "Plasma membrane, Midbody ring" "CAB036213: , CAB036214: , CAB036215: , HPA041113: AB_2677305" "unprognostic (7.21e-3)" "prognostic unfavorable (4.74e-4)" "unprognostic (4.85e-2)" "unprognostic (1.15e-2)" "unprognostic (8.86e-2)" "unprognostic (1.42e-2)" "prognostic unfavorable (7.09e-4)" "unprognostic (6.62e-3)" "unprognostic (5.68e-2)" "unprognostic (2.31e-1)" "unprognostic (1.38e-1)" "unprognostic (6.41e-2)" "prognostic unfavorable (1.55e-6)" "unprognostic (2.82e-1)" "unprognostic (9.09e-2)" "unprognostic (8.87e-2)" "unprognostic (3.19e-2)" 503.5 428.3 308.0 259.5 319.0 329.4 489.1 328.0 379.9 439.2 431.1 409.2 335.1 383.4 236.1 610.6 350.6 187.0 403.9 313.7 338.6 478.1 428.4 339.6 288.9 326.6 320.7 500.1 632.0 201.8 234.9 204.8 321.3 367.7 330.4 63.3 432.4 247.5 545.7 540.3 307.6 286.2 326.8 336.0 403.5 77.8 333.3 190.0 305.3 353.7 289.1 463.5 464.2 333.4 1638.6 2233.9 466.1 913.7 969.3 1399.2 1449.2 1091.7 954.0 1404.8 1053.5 1789.7 792.3 1314.3 1662.9 913.0 706.6 956.2 947.3 1273.3 1035.7 1604.8 3283.2 1120.3 1345.8 2513.4 1116.1 1736.0 760.5 1324.1 1420.0 901.9 1466.4 914.6 860.9 856.5 1541.7 773.7 956.1 2741.9 931.3 2144.8 831.4 2974.6 3364.2 875.9 1731.8 2157.2 1417.9 1800.2 1160.6 641.9 674.1 1472.7 1583.0 806.1 1201.7 1268.5 1013.5 1462.8 1158.2 1135.2 1774.8 1520.9 2176.6 1558.1 815.1 919.1 819.2 66.8 243.4 14.0 166.7 325.5 235.6 338.9 211.9 183.3 439.5 259.2 153.5 170.0 13.8 251.6 282.5 478.1 211.2 298.2 308.0 319.0 328.0 379.9 313.7 338.6 326.6 320.7 321.3 326.8 333.3 333.4 9.7 28.9 67.2 0.0 146.8 14.5 8.3 10.8 918.0 0.9 41.6 35.9 0.0 22.8 85.7 5.5 0.0 10.0 10.1 7.1 37.2 47.4 0.6 16.4 34.3 60.9 14.6 298.2 0.0 34.5 27.8 99.0 438.3 21.3 42.9 6.8 22.9 37.6 16.4 0.0 0.0 19.3 8.2 34.8 17.4 2.1 25.7 136.7 10.6 0.0 55.5 0.4 2.1 0.0 0.0 40.7 15.6 12.8 778.5 7.6 11.7 33.8 63.6 0.8 6.6 10.2 43.3 0.6 5.6 1490.1 14.9 8.8 87.0 6.8 25.0 11.0 NME3 "DR-nm23, NDPKC, NM23-H3" ENSG00000103024 "NME/NM23 nucleoside diphosphate kinase 3" Q13232 16 1770286-1771730 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Nucleotide metabolism" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HEK 293: 70.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041113, HPA052733" Approved Approved Nucleoplasm,Cytosol "Intracellular and membrane" NA NA 12000000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 72: Non-specific - Transcription" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm Cytosol "HPA041113: AB_2677305, HPA052733: AB_2681930" "prognostic favorable (6.81e-5)" "unprognostic (1.41e-1)" "unprognostic (1.49e-1)" "unprognostic (1.15e-3)" "unprognostic (1.26e-1)" "unprognostic (1.61e-1)" "unprognostic (1.05e-1)" "unprognostic (4.54e-2)" "unprognostic (1.13e-1)" "unprognostic (6.22e-3)" "unprognostic (4.40e-2)" "unprognostic (4.43e-2)" "unprognostic (7.09e-3)" "unprognostic (1.79e-1)" "unprognostic (3.84e-1)" "unprognostic (3.64e-1)" "unprognostic (6.11e-3)" 34.0 84.4 21.3 8.0 22.7 3.9 34.2 21.0 36.3 41.9 16.8 47.7 15.9 36.7 3.4 27.2 44.3 2.1 36.0 20.2 23.1 44.6 36.3 29.1 5.4 23.7 22.2 43.7 37.2 4.5 71.9 5.2 19.6 59.4 3.1 1.8 35.9 13.0 17.1 31.1 33.8 3.2 22.5 39.4 38.6 16.0 22.0 1.0 40.3 3.1 1.9 38.5 33.5 24.9 1.6 26.9 0.6 21.8 6.1 3.2 2.5 15.7 4.5 2.7 2.1 0.0 31.8 0.4 42.6 2.2 2.8 23.0 1.3 8.8 0.3 32.1 70.9 0.0 12.0 13.0 11.3 5.5 9.8 14.0 7.9 2.7 1.5 5.1 5.6 0.2 11.2 4.4 2.7 40.4 0.4 10.8 28.0 5.4 21.5 15.3 0.3 43.5 4.5 1.2 30.6 23.6 47.1 35.2 4.2 1.2 33.7 13.1 19.9 5.8 21.4 18.5 10.8 11.1 3.7 2.5 8.1 0.9 13.3 10.0 50.7 34.6 33.3 49.6 32.9 36.8 46.3 31.4 45.1 31.9 39.6 31.3 10.8 44.8 55.4 70.3 45.4 41.3 21.3 22.7 21.0 36.3 20.2 23.1 23.7 22.2 19.6 22.5 22.0 24.9 128.8 35.3 62.7 69.9 64.6 72.5 141.3 97.7 179.8 116.3 147.3 165.6 28.0 90.1 76.6 126.9 60.5 86.6 77.9 76.2 60.7 62.9 22.1 66.5 102.9 84.1 135.5 25.7 34.6 37.6 46.3 100.9 76.0 77.6 50.8 71.6 99.9 63.0 74.8 65.6 30.2 109.4 50.8 60.3 91.0 20.3 149.5 71.1 81.8 29.0 136.5 126.9 77.2 40.7 63.7 37.0 104.7 127.5 93.1 98.4 157.2 150.2 70.9 126.7 118.3 75.9 100.8 2.0 40.4 100.9 65.6 46.1 87.3 183.8 107.6 100.6 NME4 "NDPKD, nm23-H4, NM23H4" ENSG00000103202 "NME/NM23 nucleoside diphosphate kinase 4" O00746 16 396725-410367 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Lipid transport, Nucleotide metabolism, Transport" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal tubular cells: 250.5;Erythroid cells: 311.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB045997, HPA072588" Approved Supported Mitochondria Yes No "Cluster 26: Non-specific - Mitochondria" "Cluster 15: Liver - Metabolism" "Cluster 14: REH - Unknown function" "Cluster 33: Fibroblasts - ECM organization" Mitochondria "CAB045997: AB_11126630, HPA072588: AB_2686538" "unprognostic (3.27e-1)" "prognostic unfavorable (6.53e-4)" "unprognostic (3.70e-2)" "unprognostic (7.16e-3)" "unprognostic (1.32e-1)" "unprognostic (2.00e-1)" "unprognostic (4.40e-2)" "unprognostic (4.46e-3)" "unprognostic (1.98e-1)" "unprognostic (3.12e-1)" "unprognostic (3.74e-2)" "unprognostic (7.79e-3)" "prognostic unfavorable (1.61e-7)" "unprognostic (3.78e-2)" "unprognostic (2.16e-1)" "unprognostic (6.04e-2)" "unprognostic (3.08e-1)" 89.3 136.1 78.3 26.2 75.6 127.7 72.9 73.5 101.5 88.1 77.3 192.9 21.9 79.5 55.7 50.1 89.1 41.2 101.2 76.4 81.7 60.4 175.2 48.3 21.1 88.6 77.9 86.8 43.7 56.7 64.3 30.8 79.8 143.7 23.5 11.1 70.4 81.9 34.7 31.4 59.7 51.9 78.6 43.8 97.7 44.7 80.3 29.3 51.6 27.2 15.8 145.6 64.3 73.6 1.0 305.4 265.6 366.7 104.0 181.0 59.5 143.6 170.4 211.8 180.6 205.4 176.2 3.0 105.8 230.2 76.9 3.9 145.0 153.9 62.0 126.5 218.7 151.9 40.2 279.9 195.7 111.0 53.1 234.7 79.8 130.5 12.8 152.2 137.6 210.7 159.6 25.8 160.4 255.4 98.5 139.2 271.8 76.1 67.8 485.8 59.3 79.0 150.6 1.2 77.7 419.2 36.8 2.7 139.9 97.2 178.3 257.5 174.0 149.7 216.8 101.8 36.8 2.7 2.0 83.1 65.8 19.8 177.2 12.9 13.3 39.8 14.9 11.9 12.7 27.6 14.4 16.3 17.6 29.9 26.0 13.4 4.2 2.5 10.6 58.3 0.9 10.7 78.3 75.6 73.5 101.5 76.4 81.7 88.6 77.9 79.8 78.6 80.3 73.6 52.2 0.0 13.9 18.6 40.6 32.2 56.3 49.0 40.9 15.2 116.6 135.8 44.5 52.9 25.1 58.8 2.1 71.7 45.7 19.3 250.5 116.5 5.0 30.8 113.3 55.3 45.1 311.8 16.8 40.3 26.1 87.3 29.6 59.8 29.9 199.9 55.6 132.2 131.2 8.4 21.1 38.6 26.4 46.5 68.6 21.6 89.2 35.4 62.2 10.3 46.5 45.9 19.6 10.1 3.6 58.3 23.8 94.8 34.5 121.8 9.0 75.5 7.9 5.6 52.6 40.1 105.8 1.7 32.7 38.6 24.6 21.8 26.2 89.4 54.9 60.9 NME6 "IPIA-ALPHA, NM23-H6" ENSG00000172113 "NME/NM23 nucleoside diphosphate kinase 6" O75414 3 48290722-48301685 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Nucleotide metabolism" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017909 Approved Approved Vesicles NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" Vesicles "HPA017909: AB_1854530" "unprognostic (7.31e-3)" "unprognostic (1.87e-1)" "unprognostic (8.19e-3)" "unprognostic (2.09e-2)" "unprognostic (8.52e-2)" "unprognostic (2.20e-1)" "prognostic unfavorable (2.17e-7)" "unprognostic (1.90e-1)" "unprognostic (1.56e-1)" "unprognostic (4.00e-3)" "unprognostic (1.32e-1)" "unprognostic (2.98e-1)" "prognostic favorable (3.18e-5)" "unprognostic (1.98e-2)" "unprognostic (1.57e-2)" "unprognostic (1.23e-1)" "unprognostic (9.50e-2)" 8.7 7.7 6.3 10.4 6.4 8.1 12.1 9.2 6.3 10.2 8.7 11.6 13.2 9.3 8.5 12.1 14.8 8.9 13.5 7.1 6.5 11.1 10.3 10.2 12.2 5.9 6.3 12.4 11.6 12.4 6.0 14.2 5.7 9.5 11.5 7.6 10.9 8.7 17.7 10.0 10.4 12.4 4.9 9.6 11.5 6.2 6.4 9.4 12.2 17.2 13.7 9.6 9.0 6.3 30.0 19.1 24.3 18.3 18.2 23.4 22.1 27.2 18.3 37.5 27.3 30.5 26.5 30.1 14.0 20.5 36.5 10.1 21.9 27.2 24.1 36.1 21.3 17.9 24.1 26.6 25.7 24.3 20.7 19.7 33.8 34.4 42.9 19.3 19.8 21.1 33.9 23.6 14.0 13.9 21.4 11.3 22.3 19.5 23.3 12.7 22.9 25.3 21.2 23.6 7.7 12.7 19.8 21.0 26.1 17.8 23.9 22.5 22.1 8.3 33.0 21.2 39.4 27.0 40.9 26.1 16.3 31.9 18.4 47.3 33.4 76.4 40.9 36.0 36.6 43.5 37.4 35.2 39.9 38.0 28.1 27.2 37.3 40.4 42.1 34.5 33.5 25.1 6.3 6.4 9.2 6.3 7.1 6.5 5.9 6.3 5.7 4.9 6.4 6.3 13.1 28.9 20.7 2.3 16.4 5.0 8.5 18.2 9.6 11.9 14.1 13.6 10.4 15.7 19.4 9.2 14.6 49.5 18.4 8.2 39.2 24.8 2.6 16.1 17.5 12.8 4.2 8.0 2.5 30.1 41.6 12.4 11.7 11.8 10.1 22.8 7.9 7.9 34.4 10.1 3.2 10.8 12.2 9.3 9.7 1.7 11.8 13.7 16.0 1.9 23.4 17.6 18.6 2.5 2.7 31.3 8.3 7.2 10.8 12.8 16.6 16.4 30.6 11.5 13.1 7.7 12.2 9.3 15.0 12.4 4.1 19.7 14.7 15.1 12.8 7.1 NME7 "CFAP67, FLJ37194, NM23-H7" ENSG00000143156 "NME/NM23 family member 7" Q9Y5B8 1 169132531-169367948 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Nucleotide metabolism" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 274.9;Inhibitory neurons: 307.2;Oligodendrocytes: 277.7;Respiratory ciliated cells: 142.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028334, HPA038014, HPA054289" Approved Approved Nucleoplasm NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "HPA028334: , HPA038014: AB_10673037, HPA054289: AB_2682437" "unprognostic (1.28e-1)" "unprognostic (8.52e-2)" "unprognostic (6.21e-2)" "unprognostic (6.30e-2)" "unprognostic (1.11e-1)" "unprognostic (7.44e-3)" "prognostic unfavorable (3.24e-5)" "unprognostic (1.42e-1)" "unprognostic (1.96e-1)" "unprognostic (2.90e-1)" "unprognostic (1.05e-1)" "unprognostic (2.00e-1)" "unprognostic (6.63e-2)" "unprognostic (2.67e-2)" "unprognostic (1.12e-1)" "unprognostic (7.75e-2)" "unprognostic (2.74e-1)" 6.7 10.6 9.4 5.5 9.9 3.5 11.1 8.4 12.2 13.0 11.8 9.8 3.9 12.9 13.3 7.5 27.7 10.0 6.2 10.8 10.8 12.5 7.9 7.6 5.6 10.2 10.0 13.6 7.2 18.3 14.2 4.8 9.9 8.0 5.6 20.7 4.3 11.5 4.1 4.0 4.6 14.9 9.3 4.4 5.8 16.0 9.9 11.1 13.6 4.9 6.4 8.8 6.2 9.6 24.3 23.6 26.4 20.9 25.1 26.1 9.4 16.6 24.2 28.5 35.8 13.8 33.7 7.1 29.4 14.5 38.8 16.2 15.6 35.3 46.1 25.5 12.3 12.5 21.3 14.1 18.5 23.8 8.3 18.8 20.1 29.5 38.3 39.2 40.8 21.1 12.6 9.5 28.8 7.1 22.7 16.8 26.5 27.4 25.2 16.1 29.4 15.3 46.0 7.3 27.5 40.6 23.0 7.6 18.4 28.3 24.4 16.4 25.4 17.4 59.5 16.5 40.2 11.7 21.3 14.8 19.8 8.2 17.8 1.6 3.9 2.1 9.6 6.3 11.6 9.9 12.0 9.9 6.3 9.3 10.1 11.7 1.1 11.4 9.8 5.1 14.9 5.3 9.4 9.9 8.4 12.2 10.8 10.8 10.2 10.0 9.9 9.3 9.9 9.6 12.3 6.4 10.9 97.6 9.0 14.4 34.5 61.9 15.4 18.9 13.7 14.7 5.1 20.0 29.3 27.6 25.0 7.6 9.2 2.1 23.5 26.6 43.2 75.7 20.4 12.8 17.5 13.7 274.9 8.9 7.4 21.1 12.8 22.2 21.5 21.8 13.9 11.2 14.6 28.6 307.2 4.1 36.7 4.1 11.9 13.8 18.0 6.5 8.8 64.6 3.3 23.8 10.3 106.1 277.7 16.9 6.0 20.7 7.2 8.6 4.9 40.9 142.9 64.9 19.7 21.2 24.7 67.7 21.9 9.2 10.2 2.7 18.7 26.4 6.0 16.5 NMNAT1 "LCA9, NMNAT, PNAT1" ENSG00000173614 "Nicotinamide nucleotide adenylyltransferase 1" Q9HAN9 1 9943428-9985501 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Pyridine nucleotide biosynthesis" "Nucleotidyltransferase, Transferase" "Disease variant, Leber congenital amaurosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA059447 Approved Supported "Nucleoplasm,Nuclear bodies" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 30: Epithelial cell lines - Translation" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoplasm, Nuclear bodies" "HPA059447: AB_2684022" "unprognostic (1.94e-1)" "unprognostic (3.81e-3)" "unprognostic (7.54e-3)" "unprognostic (1.01e-1)" "unprognostic (3.50e-1)" "unprognostic (1.73e-1)" "unprognostic (1.56e-1)" "unprognostic (2.29e-1)" "unprognostic (4.45e-3)" "unprognostic (4.55e-2)" "unprognostic (1.12e-1)" "unprognostic (3.57e-1)" "prognostic favorable (3.85e-14)" "unprognostic (3.11e-3)" "unprognostic (1.17e-1)" "unprognostic (1.47e-3)" "unprognostic (5.16e-2)" 5.2 7.4 5.4 4.4 6.0 2.5 5.7 4.8 7.7 5.4 9.2 9.0 6.0 3.8 5.8 5.2 4.8 3.4 10.7 5.1 5.2 8.2 7.8 3.2 4.3 5.6 5.4 2.9 4.9 8.2 3.8 3.7 5.5 4.5 9.0 5.3 5.2 5.4 23.3 5.7 6.1 5.0 4.7 5.0 4.4 4.3 5.9 4.2 7.3 16.9 4.6 4.0 3.6 7.2 4.6 5.4 7.5 7.1 13.4 12.2 1.8 9.1 7.2 10.3 6.7 2.4 7.7 4.8 5.7 12.9 4.5 4.6 9.4 12.4 11.0 10.4 4.8 7.6 3.0 7.6 11.4 6.7 7.7 13.3 14.2 12.1 17.4 9.5 10.2 10.4 9.7 3.1 10.9 8.0 3.8 4.4 0.9 10.2 10.2 4.2 4.7 2.7 11.9 2.5 5.4 2.8 11.8 9.7 10.4 3.8 3.5 7.2 10.2 4.1 3.3 8.7 4.2 4.5 4.3 4.5 7.1 13.8 8.6 7.5 3.7 3.2 1.6 2.6 0.8 4.9 1.6 1.9 3.3 2.3 1.4 1.8 9.1 2.5 3.9 3.2 1.5 1.8 5.4 6.0 4.8 7.7 5.1 5.2 5.6 5.4 5.5 4.7 5.9 7.2 5.6 3.2 4.4 10.1 3.7 2.3 5.6 14.3 2.2 7.7 6.1 5.1 14.4 4.3 7.3 7.3 6.2 10.1 3.7 18.8 23.5 9.1 7.8 5.5 8.1 7.9 3.0 2.1 13.0 6.9 4.7 5.7 4.1 6.1 4.5 9.2 7.5 9.0 12.9 10.1 14.3 7.6 12.2 10.3 2.7 3.7 6.5 7.2 5.4 4.7 13.5 9.6 12.3 6.0 13.2 6.0 6.2 6.4 0.9 5.9 19.0 14.3 8.6 7.1 6.6 5.9 5.1 17.3 8.3 3.6 1.8 9.0 3.6 13.1 14.5 4.8 NMNAT2 "C1orf15, KIAA0479, PNAT2" ENSG00000157064 "Nicotinamide nucleotide adenylyltransferase 2" Q9BZQ4 1 183248237-183418380 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Pyridine nucleotide biosynthesis" "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 45.5;heart muscle: 18.3;pituitary gland: 18.4" "Cell type enhanced" "Detected in many" "Early spermatids: 54.3;Excitatory neurons: 195.5;Inhibitory neurons: 265.4;Oligodendrocyte precursor cells: 98.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HSkMC: 26.2;SCLC-21H: 80.6;SuSa: 25.1;U-2197: 45.8;U-87 MG: 35.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015708, HPA061714" Enhanced Approved Cytosol NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Cytosol "HPA015708: , HPA061714: AB_2732669" "unprognostic (3.70e-1)" "unprognostic (7.98e-3)" "unprognostic (8.83e-2)" "unprognostic (4.16e-2)" "unprognostic (8.95e-2)" "unprognostic (9.96e-2)" "unprognostic (1.81e-1)" "unprognostic (1.35e-1)" "unprognostic (7.92e-2)" "unprognostic (8.09e-2)" "unprognostic (1.33e-2)" "unprognostic (3.20e-1)" "unprognostic (2.73e-3)" "unprognostic (2.90e-3)" "unprognostic (1.87e-1)" "unprognostic (7.51e-2)" "unprognostic (1.02e-1)" 8.5 5.9 13.1 0.8 14.8 0.0 5.1 17.2 45.5 2.1 0.0 2.3 0.4 1.2 1.4 0.8 2.3 2.8 18.3 15.6 21.4 0.4 0.0 0.7 0.6 0.7 0.8 0.4 1.7 0.2 18.4 0.9 6.7 0.2 0.9 6.5 0.5 2.5 0.5 0.9 0.9 1.5 0.0 0.1 1.1 8.9 0.8 0.5 6.0 1.4 0.6 0.7 0.8 10.0 1.4 0.5 5.5 0.0 3.1 12.5 4.6 3.4 8.9 1.8 0.6 2.7 5.4 0.0 14.2 0.8 1.5 2.2 0.2 0.1 3.3 0.0 0.1 0.0 2.2 0.0 0.5 0.0 0.1 26.2 1.1 2.1 0.5 11.1 0.5 0.0 0.0 0.1 2.1 0.1 0.0 0.5 9.7 0.1 5.4 0.0 0.2 0.0 5.9 4.5 80.6 6.2 0.7 0.3 0.0 25.1 0.7 1.5 3.0 2.5 0.9 45.8 3.3 0.6 0.0 0.0 35.3 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.1 14.8 17.2 45.5 15.6 21.4 0.7 0.8 6.7 0.0 0.8 10.0 21.4 0.0 1.5 3.9 0.0 0.8 0.2 0.6 0.6 12.1 0.2 0.1 35.2 0.0 2.0 0.0 0.0 0.7 0.1 0.1 0.0 0.2 54.3 2.7 0.3 5.2 0.0 0.0 195.5 0.0 12.9 5.7 0.0 7.4 0.0 0.2 0.0 0.0 0.7 20.2 265.4 0.0 4.1 1.0 0.0 42.3 0.0 0.5 1.8 11.2 0.0 0.3 0.0 98.5 6.1 0.6 0.0 0.0 0.0 0.1 0.0 0.0 3.4 2.9 19.7 0.3 12.0 0.4 0.2 0.1 0.3 1.4 0.2 0.0 0.0 0.0 NMNAT3 PNAT3 ENSG00000163864 "Nicotinamide nucleotide adenylyltransferase 3" Q96T66 3 139560180-139678017 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Pyridine nucleotide biosynthesis" "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 50.1" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 567.3;Alveolar cells type 2: 566.9;Club cells: 217.6;granulocytes: 278.8;Late spermatids: 223.3;Respiratory ciliated cells: 250.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HEL: 31.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA039077, HPA057402" Approved Supported Mitochondria NA NA "Cluster 11: Basophils - Unknown function" "Cluster 6: Brain - Smell perception" "Cluster 29: U-266 - Adaptive immune response" "Cluster 11: Alveolar cells - Smell perception" Mitochondria "HPA039077: AB_2676336, HPA057402: AB_2683427" "unprognostic (9.45e-3)" "prognostic favorable (9.67e-4)" "unprognostic (2.29e-1)" "unprognostic (1.56e-3)" "unprognostic (2.33e-2)" "unprognostic (2.33e-1)" "unprognostic (2.77e-3)" "unprognostic (6.22e-2)" "unprognostic (9.69e-2)" "unprognostic (1.92e-1)" "prognostic favorable (7.29e-5)" "unprognostic (4.57e-2)" "prognostic favorable (1.95e-5)" "unprognostic (4.13e-2)" "unprognostic (1.63e-1)" "unprognostic (1.44e-1)" "unprognostic (3.07e-1)" 7.5 7.4 17.7 4.9 26.7 19.3 8.3 46.5 45.4 6.7 8.2 6.9 9.2 9.4 8.1 5.4 13.6 5.4 11.6 21.5 10.9 9.2 6.6 4.3 4.8 8.6 5.3 20.1 12.0 8.9 5.5 2.2 15.1 6.5 7.5 30.6 9.3 5.5 29.6 19.0 7.8 5.6 2.5 5.4 5.6 11.3 14.6 3.0 7.6 20.3 5.3 5.5 6.8 50.1 9.2 3.6 4.0 4.6 0.9 0.9 5.0 3.7 0.4 0.6 0.5 5.1 6.4 5.9 10.8 0.7 4.3 4.5 3.0 1.2 0.7 5.8 5.3 31.4 9.1 6.9 2.4 5.6 5.5 1.4 7.8 1.0 1.7 9.3 0.5 3.6 5.0 13.1 0.6 6.2 5.3 4.6 9.0 16.5 3.7 4.4 4.5 4.3 1.2 6.3 9.2 5.4 9.2 4.8 3.3 7.3 12.6 15.6 5.6 5.7 12.6 7.2 5.5 23.1 11.0 4.2 3.8 9.0 5.4 11.4 3.6 2.2 2.8 3.4 1.9 2.7 2.4 2.4 2.8 4.5 3.4 3.6 7.0 4.0 3.4 2.9 1.6 1.7 17.7 26.7 46.5 45.4 21.5 10.9 8.6 5.3 15.1 2.5 14.6 50.1 5.5 567.3 566.9 34.9 1.9 4.1 6.3 6.6 6.2 2.7 8.2 7.1 9.7 8.6 217.6 9.2 4.2 0.4 0.8 2.3 11.7 3.3 128.2 2.1 2.4 38.8 6.7 27.1 37.2 3.1 0.2 38.3 3.1 1.7 278.8 9.7 2.5 2.7 2.0 1.7 26.0 6.5 8.2 4.1 2.9 223.3 7.8 31.8 7.2 12.2 1.8 12.3 0.0 46.8 16.9 0.8 2.9 6.4 0.7 6.1 3.5 16.1 250.6 18.5 6.6 13.2 3.8 67.1 3.5 4.4 9.7 0.1 21.5 5.9 10.6 4.8 NMRK1 "bA235O14.2, C9orf95, FLJ20559, NRK1" ENSG00000106733 "Nicotinamide riboside kinase 1" Q9NWW6 9 75060573-75088217 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Pyridine nucleotide biosynthesis" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HDLM-2: 68.6;Karpas-707: 79.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049795 Approved Approved Nucleoplasm,Centrosome,Cytosol NA NA "Cluster 32: T-cells - Unknown function" "Cluster 18: Non-specific - Mitochondria" "Cluster 2: Karpas-707 - Immune response" "Cluster 63: NK-cells & T-cells - Immune response" "Nucleoplasm, Cytosol" Centrosome "HPA049795: AB_2680886" "unprognostic (1.12e-1)" "unprognostic (4.13e-2)" "unprognostic (3.58e-2)" "prognostic favorable (3.70e-6)" "unprognostic (3.56e-2)" "unprognostic (2.35e-1)" "unprognostic (5.20e-3)" "unprognostic (2.21e-2)" "unprognostic (3.27e-2)" "unprognostic (2.43e-1)" "unprognostic (2.06e-2)" "unprognostic (1.78e-1)" "prognostic favorable (5.60e-4)" "unprognostic (9.25e-2)" "unprognostic (1.76e-1)" "unprognostic (5.28e-2)" "unprognostic (5.64e-2)" 22.1 11.5 14.6 14.3 15.0 12.6 20.2 17.0 18.9 21.8 15.4 15.3 17.8 11.2 18.5 39.5 16.4 14.1 15.5 15.2 15.4 32.5 53.7 21.7 17.5 14.9 14.8 22.7 45.1 64.1 19.8 14.8 15.2 23.7 13.0 8.8 31.2 13.6 27.2 23.2 22.4 8.8 14.8 31.1 26.0 9.7 14.4 17.3 25.6 13.4 20.0 18.8 25.6 15.2 11.7 2.7 3.2 7.9 21.4 28.0 18.1 17.0 22.4 3.5 5.8 0.1 29.8 6.8 10.0 13.8 7.2 18.5 3.8 9.4 10.0 68.6 3.5 5.1 5.6 5.7 20.3 4.8 0.8 22.5 23.5 6.3 11.8 20.8 25.1 10.8 0.5 79.0 24.6 8.4 4.3 4.3 3.9 40.2 10.0 1.6 29.7 42.1 28.9 19.5 2.2 0.5 7.3 6.4 9.0 19.2 18.4 4.5 20.6 13.5 2.9 12.9 4.6 37.5 31.4 4.1 23.1 4.9 13.8 16.4 5.4 9.3 25.1 5.1 30.5 13.4 43.7 29.2 6.1 9.1 39.4 30.2 9.8 17.2 14.5 17.2 31.6 18.1 14.6 15.0 17.0 18.9 15.2 15.4 14.9 14.8 15.2 14.8 14.4 15.2 42.2 38.5 21.7 11.8 22.6 21.0 36.4 38.2 38.7 8.4 33.4 37.5 15.5 21.5 27.9 23.9 8.4 53.3 43.7 32.8 52.8 30.5 17.8 42.4 16.8 33.4 4.2 10.3 26.2 35.5 75.7 22.7 49.5 37.4 1.3 8.3 55.3 45.2 62.4 11.8 20.6 34.8 22.4 32.5 9.6 30.8 23.6 22.9 26.6 14.0 67.6 15.2 43.3 13.6 23.9 21.5 26.1 12.4 68.8 23.4 83.8 92.1 30.5 8.3 13.1 24.5 15.0 10.7 8.3 50.9 27.0 45.6 48.8 22.2 25.0 32.6 NMRK2 "ITGB1BP3, MIBP, NRK2" ENSG00000077009 "Nicotinamide riboside kinase 2" Q9NPI5 19 3933103-3942416 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Pyridine nucleotide biosynthesis" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 116 "heart muscle: 1438.4;skeletal muscle: 634.8;tongue: 722.1" "Cell type enriched" "Detected in some" 36 "Cardiomyocytes: 995.1" "Cancer enhanced" "Detected in some" "renal cancer: 32.8;testis cancer: 13.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "BEWO: 29.2;NTERA-2: 24.3" "Not detected" "Not detected" "Not detected" "Not detected" "HPA049909, HPA054792, HPA072450" Approved Enhanced Nucleoplasm,Vesicles NA NA "Cluster 38: Heart - Muscle contraction" "Cluster 28: BEWO - Transcription regulation" "Cluster 54: Cardiomyocytes - Muscle contraction" Nucleoplasm Vesicles "HPA049909: , HPA054792: AB_2682601, HPA072450: AB_2686522" "unprognostic (3.61e-1)" "unprognostic (5.92e-2)" "unprognostic (1.18e-2)" "unprognostic (2.54e-1)" "unprognostic (1.03e-1)" "unprognostic (7.61e-2)" "unprognostic (3.30e-2)" "prognostic favorable (1.19e-4)" "unprognostic (1.72e-1)" "unprognostic (3.29e-2)" "unprognostic (5.38e-1)" 0.7 1.7 0.2 0.0 0.2 0.0 0.8 0.2 0.8 0.2 0.2 0.5 0.0 0.4 0.1 5.7 0.6 0.0 1438.4 0.2 0.4 1.9 0.3 2.1 0.0 0.3 0.4 0.5 0.6 0.0 1.7 0.1 0.1 2.6 0.1 0.0 8.0 0.8 634.8 0.7 0.5 0.0 0.2 0.1 0.6 0.5 0.2 0.0 0.6 722.1 0.0 0.4 0.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 29.2 0.0 0.0 0.0 0.0 0.8 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 24.3 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 3.7 6.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.2 0.8 0.2 0.4 0.3 0.4 0.1 0.2 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 995.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 12.4 0.0 0.0 0.2 0.0 0.6 26.9 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.8 24.6 0.0 0.7 0.0 0.0 0.1 0.1 0.0 0.0 0.0 NMT1 NMT ENSG00000136448 "N-myristoyltransferase 1" P30419 17 44957992-45109016 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hepatocytes: 344.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA022949, HPA022963" Supported Supported "Plasma membrane,Cytosol" NA NA 94000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 39: Non-specific - Mitochondria" "Cluster 21: OE19 - Mitochondria" "Cluster 2: Hepatocytes - Metabolism" Cytosol "Plasma membrane" "HPA022949: AB_1854534, HPA022963: AB_1854535" "unprognostic (1.40e-1)" "unprognostic (2.87e-1)" "unprognostic (1.30e-2)" "unprognostic (6.14e-2)" "unprognostic (1.65e-1)" "unprognostic (1.64e-1)" "prognostic unfavorable (4.94e-4)" "unprognostic (4.96e-3)" "unprognostic (3.86e-1)" "unprognostic (3.04e-2)" "unprognostic (2.19e-1)" "unprognostic (1.98e-1)" "unprognostic (3.77e-3)" "unprognostic (1.01e-2)" "unprognostic (4.89e-2)" "unprognostic (4.17e-3)" "unprognostic (9.45e-2)" 28.3 31.8 36.2 22.3 37.7 19.5 25.8 30.3 43.4 24.7 27.9 27.8 23.6 26.4 15.7 28.8 27.7 20.3 28.3 38.8 36.4 27.3 39.5 26.5 33.6 35.4 33.7 26.3 22.2 37.8 23.3 36.6 35.0 24.5 29.2 25.7 32.1 27.6 44.6 23.9 26.4 32.9 33.9 28.4 24.5 24.9 37.2 35.2 30.7 47.6 39.5 33.0 23.5 34.9 51.5 88.8 53.7 42.3 82.9 75.0 60.6 41.4 87.6 115.9 101.0 83.9 57.0 54.0 86.2 80.4 78.4 51.5 94.5 92.3 132.9 117.9 73.3 49.0 60.7 84.4 53.7 71.0 62.6 66.4 64.1 79.1 69.2 64.1 87.1 60.9 81.8 38.1 63.1 49.2 76.2 31.7 42.4 151.5 87.8 57.5 67.2 52.2 73.6 78.8 39.2 32.9 33.0 30.2 38.0 112.8 73.1 46.0 50.1 69.9 49.5 55.8 68.1 41.4 61.0 69.9 64.5 44.5 56.4 34.9 49.4 20.0 23.8 33.3 19.9 42.3 19.9 20.1 26.2 31.0 23.7 18.8 26.5 21.1 27.6 115.5 25.7 11.8 36.2 37.7 30.3 43.4 38.8 36.4 35.4 33.7 35.0 33.9 37.2 34.9 50.1 38.5 29.5 49.3 53.8 13.9 15.4 48.8 24.5 97.8 74.1 57.1 46.5 97.2 33.6 69.9 116.7 73.7 87.5 48.7 78.2 69.4 31.1 51.5 63.1 46.4 50.9 72.0 30.3 71.2 61.9 39.6 21.9 62.3 22.8 28.1 85.3 344.4 47.6 129.5 30.7 43.0 28.5 86.5 15.9 12.2 55.0 34.6 10.6 18.7 97.9 41.5 59.8 20.1 19.3 67.9 52.0 51.1 31.0 15.3 84.1 108.1 24.0 123.5 59.2 16.1 46.3 67.6 35.5 20.5 14.1 81.8 40.1 25.4 68.6 18.6 NMT2 ENSG00000152465 "N-myristoyltransferase 2" O60551 10 15102584-15168693 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "granulocytes: 93.6;Hepatocytes: 141.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 7 "basophil: 14.5;eosinophil: 13.6;gdT-cell: 11.0;MAIT T-cell: 19.8;memory CD4 T-cell: 17.5;memory CD8 T-cell: 12.9;naive CD4 T-cell: 21.8;naive CD8 T-cell: 14.5;NK-cell: 20.8;T-reg: 29.5" "Group enriched" "Detected in many" 8 "granulocytes: 14.5;NK-cells: 20.8;T-cells: 29.5" "Cell line enhanced" "Detected in many" "fHDF/TERT166: 102.6;TIME: 147.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001303 Approved Supported "Golgi apparatus,Plasma membrane,Cytosol" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 2: Hepatocytes - Metabolism" "Golgi apparatus, Plasma membrane, Cytosol" "HPA001303: AB_1079494" "unprognostic (1.08e-1)" "unprognostic (7.65e-2)" "unprognostic (8.78e-2)" "unprognostic (1.15e-3)" "unprognostic (6.97e-2)" "unprognostic (2.24e-1)" "unprognostic (7.11e-2)" "unprognostic (5.13e-2)" "unprognostic (3.20e-1)" "unprognostic (4.01e-3)" "unprognostic (3.31e-1)" "unprognostic (2.00e-1)" "unprognostic (7.06e-2)" "unprognostic (3.79e-3)" "unprognostic (2.00e-1)" "unprognostic (1.03e-1)" "unprognostic (1.16e-1)" 25.9 4.4 7.3 6.1 8.7 3.7 17.5 12.2 10.0 9.8 4.0 8.8 6.6 12.7 3.5 7.0 8.3 7.0 8.7 7.0 4.9 9.4 16.8 6.3 8.9 5.0 7.6 15.4 5.6 16.5 5.5 4.4 5.1 9.0 9.2 7.0 5.2 7.7 8.3 10.1 10.9 10.5 4.3 9.4 7.9 13.4 9.1 27.0 5.9 8.5 8.0 8.6 7.9 7.3 8.8 11.3 12.7 9.3 33.7 35.9 2.3 18.8 15.3 17.0 23.0 10.9 38.7 0.4 12.7 102.6 46.6 10.6 11.4 10.7 28.3 11.7 13.9 23.4 5.4 15.2 22.4 1.7 84.0 31.9 10.8 23.8 7.2 62.2 65.8 16.3 11.2 1.5 63.7 10.9 18.3 4.4 9.3 10.0 10.5 13.6 18.5 1.8 12.6 1.8 3.9 14.4 22.8 3.7 6.3 10.5 11.7 7.3 147.1 16.7 24.4 75.0 13.7 13.0 14.3 1.0 20.7 6.3 12.4 14.5 0.5 13.6 11.0 0.7 19.8 2.2 17.5 12.9 0.5 2.5 21.8 14.5 1.9 20.8 0.8 0.5 29.5 6.5 7.3 8.7 12.2 10.0 7.0 4.9 5.0 7.6 5.1 4.3 9.1 7.3 52.5 9.6 8.8 25.1 16.0 16.6 23.4 8.3 7.4 20.6 14.7 13.1 13.5 57.2 10.9 27.6 4.2 1.3 16.9 32.8 9.8 33.9 6.6 4.7 20.5 21.7 18.0 15.1 39.6 19.5 3.0 16.3 9.2 10.3 93.6 13.2 25.4 141.9 2.8 20.2 30.1 11.4 4.1 7.9 7.1 14.5 21.8 5.8 12.4 17.8 10.1 12.9 40.2 12.5 15.3 27.1 15.9 20.7 10.0 17.9 38.4 63.2 5.3 17.2 0.0 13.4 21.0 8.1 46.8 6.8 14.8 2.6 33.9 11.0 18.1 16.7 NNMT ENSG00000166741 "Nicotinamide N-methyltransferase" P40261 11 114257787-114313536 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Methyltransferase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 388.9" "Group enriched" "Detected in many" 6 "Hepatocytes: 3913.2;Skeletal myocytes: 1639.1" "Cancer enhanced" "Detected in all" "renal cancer: 204.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HSkMC: 255.3;LHCN-M2: 144.1;RPTEC TERT1: 479.6" "Low region specificity" "Detected in many" "Not detected" "Not detected" HPA059180 Approved Approved "Golgi apparatus,Cytosol" NA NA 410000 "Cluster 85: Liver - Metabolism" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 2: Hepatocytes - Metabolism" "Golgi apparatus" Cytosol "HPA059180: AB_2683940" "unprognostic (1.62e-1)" "unprognostic (2.33e-2)" "unprognostic (1.61e-2)" "unprognostic (6.14e-2)" "unprognostic (3.51e-1)" "prognostic unfavorable (2.07e-4)" "unprognostic (1.76e-1)" "unprognostic (5.84e-2)" "unprognostic (2.71e-2)" "unprognostic (2.48e-2)" "unprognostic (1.20e-1)" "unprognostic (1.69e-2)" "prognostic unfavorable (1.02e-6)" "prognostic unfavorable (1.75e-4)" "unprognostic (1.11e-1)" "unprognostic (3.37e-3)" "unprognostic (2.77e-2)" 130.9 11.4 1.0 25.2 1.1 0.9 91.9 1.4 1.5 36.0 1.9 37.1 1.5 31.0 2.8 15.4 55.0 43.1 35.5 1.3 1.4 24.1 388.9 64.6 9.6 3.9 1.6 21.3 11.4 1.6 10.6 23.8 2.2 31.9 8.7 0.3 21.1 3.1 73.1 49.3 32.2 30.1 1.7 36.7 30.1 2.2 1.2 2.7 33.0 5.3 8.8 48.6 33.9 3.1 0.2 17.6 0.3 18.6 92.0 118.3 0.1 21.2 58.7 35.2 69.2 0.0 17.5 0.2 58.1 45.1 4.2 0.2 0.0 8.0 34.1 0.2 0.0 0.2 16.7 0.0 123.3 0.2 0.0 255.3 89.4 24.1 37.3 29.8 50.1 0.1 0.3 0.2 144.1 0.1 0.1 0.2 0.1 0.0 0.5 0.2 79.0 0.0 479.6 0.1 0.2 0.2 97.7 0.1 0.3 5.3 0.0 0.2 37.4 18.3 34.3 23.8 3.1 0.3 0.3 0.4 6.4 0.3 1.4 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.0 1.0 1.1 1.4 1.5 1.3 1.4 3.9 1.6 2.2 1.7 1.2 3.1 411.8 44.8 411.3 1.0 11.2 103.6 13.2 16.5 2.2 1.9 38.5 73.9 4.7 75.8 13.3 80.9 0.0 1.0 1.6 0.0 9.8 238.3 0.3 19.0 89.9 190.0 5.3 147.2 1.3 157.0 2.5 452.2 5.1 80.5 13.9 0.5 195.2 3913.2 28.4 0.0 1.6 0.0 0.0 126.8 142.1 1.6 74.3 9.2 96.0 1.9 5.7 0.0 0.0 0.0 0.2 323.1 0.0 13.2 1.5 10.8 0.0 99.2 11.9 0.2 0.0 1639.1 154.3 0.3 0.8 1.9 92.1 2.2 20.1 0.0 0.0 3.1 NOSIP CGI-25 ENSG00000142546 "Nitric oxide synthase interacting protein" Q9Y314 19 49555468-49590262 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Developmental protein, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 364.8;Late spermatids: 844.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA043464, HPA062132" Approved Enhanced Nucleoplasm NA NA "Cluster 32: T-cells - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 63: NK-cells & T-cells - Immune response" Nucleoplasm "HPA043464: AB_10794284, HPA062132: AB_2684693" "unprognostic (2.27e-1)" "unprognostic (4.69e-2)" "unprognostic (1.39e-1)" "unprognostic (4.17e-2)" "unprognostic (1.59e-2)" "unprognostic (9.46e-2)" "unprognostic (1.47e-2)" "unprognostic (9.42e-2)" "unprognostic (3.79e-1)" "unprognostic (1.25e-1)" "unprognostic (2.27e-2)" "unprognostic (9.73e-2)" "unprognostic (3.97e-2)" "unprognostic (2.15e-1)" "unprognostic (9.76e-2)" "unprognostic (1.02e-1)" "unprognostic (2.95e-3)" 42.4 48.0 33.2 27.1 37.0 31.7 42.8 37.2 45.1 50.0 29.4 49.0 29.1 49.3 10.0 47.8 45.1 15.4 60.9 31.9 35.0 48.1 48.6 39.5 51.8 36.2 34.9 44.5 125.1 24.0 40.8 21.6 36.9 44.0 14.6 10.1 38.3 20.6 134.7 46.7 50.8 16.2 34.7 63.2 44.8 143.5 36.0 40.0 40.9 65.2 26.5 41.3 41.7 38.0 239.7 114.5 49.6 113.1 43.5 32.7 44.5 54.8 50.0 90.9 85.3 84.9 43.1 63.4 93.5 48.2 37.0 51.0 47.8 98.4 40.3 74.1 126.0 81.3 67.9 96.6 66.6 67.8 64.6 43.4 66.5 71.4 37.7 38.0 54.4 101.8 90.7 46.0 50.3 59.7 66.2 127.0 65.9 89.3 100.4 89.3 74.0 58.3 43.5 70.6 57.4 71.2 74.9 59.1 50.2 21.8 53.9 72.6 83.5 83.6 64.4 27.0 99.3 87.8 186.7 86.6 31.2 90.7 65.2 261.9 129.1 192.3 257.3 126.1 328.8 161.8 519.8 294.6 127.8 157.2 841.3 466.7 244.1 244.5 117.6 168.8 303.6 579.4 33.2 37.0 37.2 45.1 31.9 35.0 36.2 34.9 36.9 34.7 36.0 38.0 78.3 19.2 34.9 13.1 67.3 72.8 54.8 109.8 40.9 25.4 45.5 49.5 38.4 62.9 59.3 51.5 22.9 94.2 74.7 171.6 86.1 84.5 364.8 56.3 44.9 73.0 58.7 58.5 9.2 283.6 85.0 51.7 57.6 68.6 68.4 57.0 93.9 49.5 72.2 11.8 9.1 108.9 91.6 63.8 67.0 844.8 71.7 55.5 62.2 13.1 100.5 45.5 120.5 9.0 12.3 219.2 138.2 72.2 55.4 43.2 129.6 133.8 58.4 37.2 59.2 85.1 66.1 268.7 50.9 39.6 76.3 136.3 154.2 73.1 108.5 54.4 NRK DKFZp686A17109 ENSG00000123572 "Nik related kinase" Q7Z2Y5 X 105822539-105958610 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adrenal gland: 16.1;ovary: 32.5;placenta: 24.2" "Group enriched" "Detected in some" 4 "Cytotrophoblasts: 79.4;Leydig cells: 113.4;Syncytiotrophoblasts: 67.9;Theca cells: 70.2" "Cancer enriched" "Detected in some" 8 "testis cancer: 6.1" "Region enriched" "Detected in single" 11 "cerebellum: 7.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "fHDF/TERT166: 58.1;HSkMC: 10.6;RH-30: 12.8;RPTEC TERT1: 34.8;SuSa: 40.5" "Region enriched" "Detected in single" 28 "cerebellum: 14.2" "Region enhanced" "Detected in all" "cerebellum: 41.6" HPA017238 Uncertain Approved Nucleoplasm,Cytosol NA NA "Cluster 89: Fibroblasts - ECM organization" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 47: Cytotrophoblasts - Unknown function" "Nucleoplasm, Cytosol" "HPA017238: AB_1854645" "unprognostic (2.64e-4)" "unprognostic (9.82e-2)" "unprognostic (5.98e-3)" "unprognostic (5.52e-2)" "unprognostic (3.87e-2)" "unprognostic (2.29e-2)" "unprognostic (1.12e-1)" "unprognostic (2.86e-2)" "unprognostic (1.35e-2)" "unprognostic (6.08e-2)" "unprognostic (3.24e-2)" "unprognostic (5.28e-3)" "unprognostic (1.47e-3)" "unprognostic (1.14e-1)" "unprognostic (4.28e-2)" "unprognostic (6.80e-3)" 0.8 16.1 0.0 0.9 0.0 0.0 0.7 7.0 0.3 1.8 0.0 1.4 0.1 1.7 4.6 0.6 0.9 10.1 3.5 0.0 0.1 6.2 0.1 0.2 0.0 0.1 0.6 32.5 0.4 0.1 0.3 24.2 0.5 4.9 0.3 0.1 1.1 0.9 0.2 0.1 0.3 1.7 0.1 0.0 0.5 3.3 0.0 0.1 0.2 3.3 0.0 1.0 0.6 0.4 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 58.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 10.6 0.0 0.1 0.0 3.5 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 12.8 0.0 34.8 0.7 0.0 0.2 0.0 1.8 0.0 40.5 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.0 0.3 0.0 0.1 0.1 0.6 0.5 0.1 0.0 0.4 3.0 0.0 0.0 0.7 0.0 0.0 0.1 0.0 0.6 0.0 1.2 1.0 4.8 0.0 0.0 0.0 0.0 79.4 0.0 0.2 19.6 0.2 1.3 0.0 3.2 0.7 0.0 0.0 0.9 0.0 10.1 8.9 0.0 0.0 0.0 2.1 0.0 0.0 7.1 0.0 0.9 0.0 0.0 0.0 0.0 2.6 113.4 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.4 13.5 0.0 0.2 0.2 0.2 0.0 0.0 0.0 0.1 0.7 1.6 1.7 0.1 0.0 67.9 0.0 70.2 0.2 0.1 NSD1 "ARA267, FLJ22263, KMT3B, STO" ENSG00000165671 "Nuclear receptor binding SET domain protein 1" Q96L73 5 177133025-177300213 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Transcription, Transcription regulation" "Activator, Chromatin regulator, Methyltransferase, Repressor, Transferase" "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA048431, HPA070333, HPA073705" Supported Supported "Nucleoplasm,Plasma membrane" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 44: HDLM-2 - Immune response" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Plasma membrane" "HPA048431: AB_2680388, HPA070333: AB_2686255, HPA073705: AB_2732239" "unprognostic (3.48e-2)" "unprognostic (7.46e-2)" "unprognostic (7.14e-3)" "unprognostic (2.64e-3)" "unprognostic (1.38e-1)" "unprognostic (9.67e-2)" "unprognostic (2.29e-2)" "unprognostic (7.08e-2)" "unprognostic (1.68e-3)" "unprognostic (8.04e-2)" "unprognostic (1.48e-1)" "unprognostic (2.09e-1)" "unprognostic (7.77e-3)" "unprognostic (3.53e-2)" "unprognostic (1.01e-1)" "unprognostic (7.51e-2)" "unprognostic (7.32e-2)" 8.7 7.2 8.9 12.0 13.4 21.2 10.9 26.2 10.4 11.1 9.8 10.1 8.4 11.5 10.3 11.4 10.1 8.0 9.1 7.7 10.0 10.6 6.6 9.2 13.7 9.7 10.8 12.3 11.3 12.8 9.0 10.7 12.2 9.3 10.8 11.9 10.4 9.6 13.6 12.0 9.4 12.0 6.6 11.3 8.9 23.2 12.0 20.2 15.5 11.5 14.7 9.3 7.9 17.5 20.5 25.9 26.0 22.8 12.5 16.1 0.9 18.2 17.9 24.6 22.8 5.7 16.6 41.7 19.9 24.8 22.7 17.0 41.9 40.0 29.7 72.9 25.9 18.6 29.5 0.2 20.7 40.4 21.2 15.2 23.6 29.4 27.3 17.5 36.4 26.0 25.9 14.3 25.2 42.3 28.3 13.1 28.5 13.7 22.5 31.0 3.4 12.9 15.9 24.4 31.6 21.9 46.7 20.1 13.8 24.1 20.2 33.0 27.4 17.1 25.0 11.0 22.6 16.7 15.7 29.5 9.9 19.3 18.7 14.7 9.0 10.5 7.2 6.1 6.0 8.5 6.1 5.0 7.2 10.3 7.5 6.0 18.6 11.3 12.2 9.4 6.4 3.4 8.9 13.4 26.2 10.4 7.7 10.0 9.7 10.8 12.2 6.6 12.0 17.5 37.4 22.4 31.4 84.9 71.7 17.0 32.8 27.2 34.1 94.4 29.8 25.7 44.5 34.3 35.0 55.2 150.1 43.6 66.1 19.7 17.6 27.8 31.9 27.1 65.7 36.4 41.9 48.3 107.0 21.2 23.7 32.7 41.8 41.9 41.7 64.0 33.5 19.9 27.7 89.2 110.3 25.6 12.2 36.8 25.7 50.3 51.0 47.1 16.0 115.2 75.0 29.2 95.8 140.8 157.5 23.7 31.0 33.1 55.8 29.4 33.6 19.2 17.3 112.3 52.6 42.9 36.1 83.7 62.1 41.8 20.6 35.4 62.0 55.9 28.2 30.0 NSD2 "KMT3G, MMSET, WHSC1" ENSG00000109685 "Nuclear receptor binding SET domain protein 2" O96028 4 1871393-1982207 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Chromatin regulator, DNA-binding, Methyltransferase, Transferase" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Glandular and luminal cells: 20.3;Granulosa cells: 69.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015801, CAB068246, CAB068247" Enhanced Supported Nucleoplasm No No "Cluster 17: Basophils - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 40: Granulosa cells - Unknown function" Nucleoplasm "CAB068246: AB_2665690, CAB068247: AB_2665689, HPA015801: AB_1858830" "unprognostic (3.70e-1)" "unprognostic (9.80e-2)" "unprognostic (3.33e-2)" "unprognostic (1.77e-1)" "unprognostic (4.01e-1)" "unprognostic (1.31e-2)" "prognostic unfavorable (2.61e-4)" "unprognostic (3.24e-2)" "unprognostic (6.22e-2)" "unprognostic (7.66e-2)" "unprognostic (2.09e-1)" "unprognostic (9.25e-3)" "prognostic unfavorable (7.19e-4)" "unprognostic (3.89e-2)" "unprognostic (2.95e-1)" "unprognostic (1.31e-1)" "unprognostic (6.15e-2)" 10.1 8.4 12.7 16.5 13.0 54.9 9.9 23.6 15.2 9.4 0.8 19.6 18.6 10.7 7.3 13.6 8.4 8.3 15.8 11.8 11.5 9.8 8.3 12.6 25.4 9.8 8.6 7.7 13.5 12.0 13.8 12.2 12.0 9.7 22.5 28.5 11.6 8.4 16.7 11.6 18.3 12.4 4.4 14.1 12.5 37.2 12.6 59.8 17.4 13.7 24.3 9.7 9.2 14.9 124.0 58.6 168.3 71.2 17.5 26.5 44.2 98.2 85.4 115.2 128.8 44.6 141.4 117.5 31.4 78.0 158.5 50.2 114.4 74.3 195.0 58.3 47.7 151.3 81.7 25.5 18.6 89.5 74.9 9.9 19.8 101.2 89.9 60.1 92.2 123.4 81.7 132.2 95.8 42.1 243.3 99.7 68.8 60.1 77.1 137.8 106.7 42.9 45.4 57.4 115.6 82.7 78.4 29.2 31.7 71.4 68.9 52.2 64.9 109.0 87.4 72.8 188.1 54.1 72.9 113.7 66.0 81.9 108.0 4.0 1.1 1.3 1.0 0.8 1.1 0.9 1.5 1.2 1.2 1.7 1.1 0.8 3.4 1.2 0.5 2.1 2.9 0.7 12.7 13.0 23.6 15.2 11.8 11.5 9.8 8.6 12.0 4.4 12.6 14.9 12.6 12.8 18.4 0.0 4.1 0.0 0.0 0.0 0.0 0.0 15.3 9.1 0.0 0.0 8.1 12.9 0.0 15.7 7.2 0.0 3.9 10.4 0.0 13.0 11.7 6.3 0.0 0.0 0.0 7.1 10.0 6.0 0.0 20.3 2.5 69.3 0.0 0.0 13.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.3 0.0 0.0 5.7 0.0 0.0 0.0 0.0 11.4 0.0 0.0 4.9 0.0 0.0 4.0 7.3 0.0 0.0 0.0 8.4 0.0 0.0 0.0 0.0 3.4 5.2 3.7 0.0 0.0 NSD3 "FLJ20353, KMT3F, WHISTLE, WHSC1L1" ENSG00000147548 "Nuclear receptor binding SET domain protein 3" Q9BZ95 8 38269704-38382272 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Transcription, Transcription regulation" "Chromatin regulator, Methyltransferase, Transferase" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 173.8;Syncytiotrophoblasts: 130.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005659, CAB013721, HPA018893" Uncertain Approved Nucleoplasm,Mitochondria NA NA "Cluster 37: B-cells - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 7: Non-specific - Mitochondria" Mitochondria Nucleoplasm "CAB013721: , HPA005659: AB_1080596, HPA018893: AB_1858833" "unprognostic (6.21e-2)" "unprognostic (3.73e-2)" "unprognostic (2.18e-2)" "unprognostic (4.12e-1)" "unprognostic (2.25e-1)" "unprognostic (1.53e-2)" "unprognostic (4.35e-2)" "unprognostic (1.97e-2)" "unprognostic (2.49e-1)" "unprognostic (5.72e-2)" "prognostic unfavorable (7.48e-4)" "unprognostic (5.06e-2)" "unprognostic (5.60e-3)" "unprognostic (6.69e-2)" "unprognostic (4.04e-1)" "unprognostic (1.05e-2)" "unprognostic (1.60e-2)" 22.4 14.4 10.0 24.8 13.7 60.2 23.4 28.4 20.5 24.0 0.7 22.4 24.1 22.9 17.4 22.9 23.5 24.5 13.7 12.8 22.3 20.0 16.6 20.6 35.3 3.1 4.8 36.4 20.1 24.8 17.3 33.5 5.3 20.9 26.6 23.3 19.9 24.3 14.4 19.8 26.7 19.8 0.1 26.9 29.0 14.4 10.4 38.3 27.6 16.0 31.0 23.3 23.1 18.7 62.1 34.9 58.7 39.9 40.3 46.0 43.4 50.8 55.9 43.1 49.7 18.8 33.6 73.5 45.5 35.0 41.7 36.4 47.0 40.6 61.0 29.4 27.6 93.6 28.6 22.1 41.2 41.7 32.5 24.9 40.4 39.0 78.6 40.3 50.1 79.8 67.9 47.4 41.5 22.3 122.8 35.4 40.0 48.0 16.4 55.5 64.1 23.4 30.3 47.3 33.0 44.6 41.4 35.8 35.3 37.5 45.1 31.4 48.3 44.5 46.0 67.0 30.3 41.9 53.8 69.2 37.6 41.3 33.0 37.4 11.8 21.9 17.2 5.6 11.0 43.1 25.5 15.5 9.3 60.7 31.9 13.7 57.9 19.6 3.6 12.6 43.4 7.3 10.0 13.7 28.4 20.5 12.8 22.3 3.1 4.8 5.3 0.1 10.4 18.7 75.1 67.3 57.3 0.0 57.8 0.0 0.0 0.0 0.0 0.0 73.4 69.1 0.0 0.0 30.3 51.5 0.0 101.6 101.9 0.0 23.5 73.0 0.0 109.1 81.3 28.0 0.0 0.0 0.0 61.0 173.8 33.1 0.0 97.5 8.8 99.7 0.0 0.0 44.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 30.1 0.0 0.0 49.7 0.0 0.0 0.0 0.0 64.7 0.0 0.0 48.9 0.0 0.0 31.7 34.2 0.0 0.0 0.0 35.8 0.0 0.0 0.0 0.0 130.8 55.6 81.7 0.0 0.0 NSMCE1 NSE1 ENSG00000169189 "NSE1 homolog, SMC5-SMC6 complex component" Q8WV22 16 27224994-27268772 "Enzymes, Predicted intracellular proteins" "DNA damage, DNA recombination, DNA repair, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "granulocytes: 275.5;Late spermatids: 420.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041567, HPA043091" Supported Supported Nucleoplasm,Vesicles NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 43: Testis - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 31: Spermatids - Spermatogenesis" "Nucleoplasm, Vesicles" "HPA041567: AB_10964260, HPA043091: AB_10962722" "unprognostic (6.27e-2)" "unprognostic (8.17e-2)" "unprognostic (2.52e-2)" "unprognostic (2.48e-3)" "unprognostic (4.17e-1)" "unprognostic (4.52e-3)" "unprognostic (1.59e-1)" "unprognostic (1.06e-1)" "unprognostic (1.79e-1)" "unprognostic (1.22e-1)" "unprognostic (1.93e-1)" "unprognostic (9.91e-2)" "unprognostic (1.40e-1)" "unprognostic (5.45e-3)" "unprognostic (3.58e-1)" "unprognostic (1.46e-1)" "unprognostic (1.29e-1)" 43.8 68.3 58.8 32.2 61.7 35.1 52.5 65.2 71.7 43.3 66.0 53.1 25.3 42.3 55.0 45.5 62.2 35.8 47.6 57.4 63.3 58.3 55.9 42.4 54.5 65.5 61.4 45.0 59.3 86.1 37.3 37.3 64.6 57.4 36.8 24.9 46.2 51.7 45.2 40.7 37.0 45.2 64.0 33.5 51.3 79.8 61.3 56.4 53.0 44.9 54.7 51.4 39.1 67.0 56.5 80.6 53.8 58.6 85.8 114.2 43.1 58.9 60.4 44.5 46.1 62.7 134.1 110.0 137.7 91.1 45.7 59.5 101.9 178.6 57.3 136.3 70.6 51.0 68.6 122.1 149.1 59.9 37.4 112.6 122.3 111.7 211.5 127.8 60.3 104.3 69.6 33.8 82.9 96.7 80.0 67.5 46.8 94.0 54.7 69.1 65.8 174.7 129.9 36.3 56.4 51.0 40.2 55.9 104.3 65.1 92.3 71.9 37.8 53.3 33.2 61.1 57.8 101.0 78.1 85.9 114.0 59.4 23.3 125.3 91.2 86.2 78.9 81.6 86.3 84.2 111.1 95.7 128.4 133.1 126.7 99.7 29.6 213.8 81.5 124.6 113.0 120.3 58.8 61.7 65.2 71.7 57.4 63.3 65.5 61.4 64.6 64.0 61.3 67.0 34.8 35.3 36.4 8.5 38.1 28.3 57.6 110.7 33.0 14.9 60.7 83.8 49.6 62.9 58.5 44.1 2.1 126.2 41.2 45.6 129.1 79.2 209.9 40.3 32.9 33.9 58.7 24.0 5.4 73.0 63.3 44.5 17.3 29.6 275.5 37.4 52.8 64.0 83.2 13.5 6.7 65.8 44.7 53.3 45.6 420.8 24.2 39.5 46.2 12.2 98.1 64.7 43.3 12.5 14.8 40.1 45.7 39.9 28.1 49.0 83.9 173.8 94.6 18.8 26.3 58.1 50.1 119.0 39.4 43.5 32.7 64.3 55.3 39.9 46.7 48.3 NSUN2 "FLJ20303, Misu, MRT5, TRM4" ENSG00000037474 "NOP2/Sun RNA methyltransferase 2" Q08J23 5 6599239-6633291 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Differentiation, Mitosis, Spermatogenesis, tRNA processing" "Methyltransferase, RNA-binding, Transferase, tRNA-binding" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA037896 Supported Approved Nucleoplasm "Intracellular and membrane" NA NA 110000 "Cluster 44: Non-specific - Transcription" "Cluster 52: Non-specific - Ribosome" "Cluster 20: HeLa - Mitochondria" "Cluster 59: Non-specific - Transcription" Nucleoplasm "HPA037896: AB_10670532" "unprognostic (3.99e-2)" "unprognostic (5.73e-2)" "unprognostic (1.44e-1)" "unprognostic (7.66e-3)" "unprognostic (8.56e-2)" "unprognostic (5.21e-2)" "unprognostic (1.44e-3)" "unprognostic (5.12e-2)" "unprognostic (4.48e-2)" "unprognostic (1.41e-1)" "unprognostic (1.84e-1)" "unprognostic (2.48e-2)" "prognostic unfavorable (5.69e-5)" "unprognostic (1.98e-1)" "unprognostic (1.47e-1)" "unprognostic (4.30e-3)" "unprognostic (1.70e-2)" 21.6 16.0 10.4 29.1 10.9 28.2 38.6 11.3 13.4 16.2 12.0 24.7 20.8 18.2 19.5 24.1 17.7 17.8 23.0 10.8 11.3 16.4 36.7 19.5 34.3 11.2 10.6 18.0 20.0 24.9 11.5 19.8 11.2 20.7 27.7 10.9 17.9 17.0 39.0 22.7 20.4 22.4 10.4 23.0 21.4 18.9 11.8 26.5 18.0 30.2 36.8 29.3 15.0 13.2 97.6 85.8 49.9 45.4 31.7 36.1 112.9 72.5 48.6 84.4 71.5 113.0 75.6 170.6 74.0 63.8 101.6 70.7 102.1 90.6 114.6 115.1 73.4 100.8 199.0 67.0 44.8 176.8 77.4 40.2 67.5 91.8 80.5 33.6 60.6 70.3 132.3 66.3 79.9 71.1 93.2 89.3 80.0 69.3 101.3 121.1 50.5 54.7 61.7 112.1 45.8 65.4 184.4 101.2 79.1 65.0 85.0 84.2 66.6 66.8 82.0 68.4 111.1 51.2 100.1 159.9 52.9 143.9 77.6 16.2 18.6 21.2 21.1 22.4 27.9 22.4 22.1 25.0 21.5 20.6 23.2 23.5 3.9 24.4 21.2 20.2 17.0 17.0 10.4 10.9 11.3 13.4 10.8 11.3 11.2 10.6 11.2 10.4 11.8 13.2 13.2 19.2 17.6 27.7 26.3 37.7 16.4 15.7 21.6 6.2 15.5 14.2 18.7 17.2 30.3 18.4 14.6 20.1 17.1 16.2 9.8 19.6 3.1 11.2 12.9 16.2 14.9 22.3 37.2 15.3 21.2 14.5 17.9 14.1 20.8 17.8 10.0 33.9 14.4 3.3 30.2 16.5 16.2 18.5 21.1 2.9 13.1 16.4 16.0 20.6 21.9 7.2 21.6 24.1 45.4 24.8 14.8 14.3 23.0 18.9 10.2 9.8 17.4 7.3 6.6 20.2 15.4 14.9 17.7 30.1 30.5 23.1 20.7 17.2 19.8 17.0 NTMT1 "AD-003, C9orf32, HOMT1A, METTL11A, NRMT, NRMT1" ENSG00000148335 "N-terminal Xaa-Pro-Lys N-methyltransferase 1" Q9BV86 9 129608884-129636135 "Enzymes, Predicted intracellular proteins" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 4 "Early spermatids: 391.4;Late spermatids: 761.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020092, HPA058420" Uncertain Enhanced Nucleoplasm,Cytosol NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 31: Spermatids - Spermatogenesis" Nucleoplasm Cytosol "HPA020092: AB_1853831, HPA058420: AB_2683713" "unprognostic (4.74e-3)" "unprognostic (1.77e-1)" "unprognostic (2.44e-1)" "unprognostic (1.48e-1)" "unprognostic (1.17e-1)" "unprognostic (1.24e-3)" "unprognostic (4.17e-3)" "unprognostic (4.92e-2)" "unprognostic (1.24e-1)" "unprognostic (8.57e-2)" "unprognostic (3.63e-1)" "unprognostic (4.35e-2)" "unprognostic (1.00e-3)" "unprognostic (1.11e-3)" "unprognostic (1.75e-1)" "unprognostic (5.58e-2)" "unprognostic (3.50e-3)" 26.4 68.6 20.6 19.3 21.7 24.5 22.1 23.6 27.0 22.5 22.4 23.2 18.3 19.6 15.9 20.2 18.9 19.9 67.9 21.0 23.1 31.5 41.6 22.8 20.2 22.5 23.8 19.8 31.1 22.4 23.4 19.6 22.5 22.7 11.2 6.3 22.4 16.7 98.9 25.1 19.5 13.7 21.3 29.7 24.9 93.3 22.9 16.1 17.9 84.3 16.0 23.9 20.0 24.1 57.8 117.2 47.9 82.2 30.0 44.6 50.2 107.6 63.5 108.1 92.8 96.6 74.0 74.8 53.7 78.5 76.7 110.1 101.8 96.4 66.8 56.3 50.9 31.2 106.3 100.4 96.3 63.3 45.0 47.0 48.6 113.5 56.0 34.2 60.1 64.1 116.5 54.2 57.5 194.1 72.0 85.6 62.6 105.4 96.6 66.8 55.8 150.4 43.7 32.4 96.5 48.5 53.1 97.3 74.7 30.2 81.4 32.4 41.8 129.1 64.5 118.7 115.3 41.2 53.7 115.2 59.0 64.4 75.0 32.9 49.7 39.2 43.7 55.1 43.7 43.2 43.5 46.5 49.2 50.4 43.9 36.3 13.6 30.6 70.9 52.8 44.5 36.4 20.6 21.7 23.6 27.0 21.0 23.1 22.5 23.8 22.5 21.3 22.9 24.1 35.6 3.2 13.9 5.9 45.9 99.8 85.7 50.3 16.5 18.3 33.4 33.8 4.1 20.0 35.7 22.0 22.9 72.6 23.1 49.7 97.8 60.5 391.4 21.4 29.8 38.3 20.3 23.4 6.4 55.9 86.8 41.1 21.9 23.2 30.4 20.5 20.0 52.7 67.0 42.1 6.5 44.0 42.7 27.6 80.3 761.6 35.1 34.3 55.2 3.7 33.1 23.3 25.7 4.5 9.2 69.2 29.9 24.8 41.0 105.7 84.5 89.6 22.5 23.6 26.3 34.1 58.8 129.2 43.2 19.2 99.3 135.6 38.3 39.2 48.4 70.7 NTRK1 "MTC, TRK, TRKA" ENSG00000198400 "Neurotrophic receptor tyrosine kinase 1" P04629 1 156815640-156881850 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" "Differentiation, Neurogenesis" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "adrenal gland: 7.0;brain: 21.7" "Group enriched" "Detected in some" 10 "Bipolar cells: 22.8;granulocytes: 55.9;Horizontal cells: 57.2" "Cancer enhanced" "Detected in some" "glioma: 1.3" "Group enriched" "Detected in many" 6 "cerebral cortex: 7.6;medulla oblongata: 19.8;pons: 21.7" "Immune cell enriched" "Detected in single" 116 "basophil: 94.5" "Lineage enriched" "Detected in single" 768 "granulocytes: 94.5" "Cell line enriched" "Detected in some" 4 "HMC-1: 82.1" "Region enhanced" "Detected in many" "basal ganglia: 8.4" "Region enriched" "Detected in single" 6 "basal ganglia: 4.1" "CAB004606, HPA035799, HPA076570" Approved Approved Vesicles,Cytosol NA NA 79000 "Cluster 38: Basophils - Unknown function" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 3: HMC-1 - Innate immune response" "Cluster 62: Horizontal cells - Visual perception" "Vesicles, Cytosol" "CAB004606: AB_628397, HPA035799: AB_2674788, HPA076570: " "unprognostic (5.89e-3)" "unprognostic (7.56e-2)" "unprognostic (2.74e-2)" "unprognostic (5.99e-3)" "unprognostic (7.26e-2)" "unprognostic (1.43e-3)" "unprognostic (1.56e-1)" "unprognostic (7.42e-3)" "unprognostic (7.63e-2)" "unprognostic (1.35e-1)" "unprognostic (6.73e-2)" "unprognostic (2.29e-2)" "unprognostic (3.18e-11)" "unprognostic (2.18e-3)" "unprognostic (3.79e-2)" "unprognostic (1.07e-1)" "unprognostic (4.89e-1)" 0.8 7.0 0.7 0.4 1.8 0.7 0.2 1.8 7.6 0.7 0.7 0.8 0.5 1.0 0.0 0.1 0.5 0.4 1.0 0.3 2.8 3.0 0.0 0.5 0.1 19.8 1.5 0.1 0.2 0.0 0.7 0.2 21.7 1.4 0.0 1.9 0.5 0.3 0.4 0.1 0.3 0.6 0.2 0.1 0.5 1.6 0.4 0.3 0.2 0.2 0.0 0.3 0.5 0.6 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.2 0.1 0.0 0.0 0.0 11.9 0.0 14.0 0.0 0.0 0.0 0.0 82.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 4.4 1.6 0.0 0.2 0.0 2.4 0.2 0.0 1.5 2.5 0.0 0.2 0.0 0.5 1.5 18.2 0.0 0.1 0.0 0.3 0.0 0.1 0.3 0.0 1.1 0.0 0.0 3.5 0.6 0.0 0.0 0.0 0.1 94.5 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.0 0.2 0.7 1.8 1.8 7.6 0.3 2.8 19.8 1.5 21.7 0.2 0.4 0.6 0.1 0.0 1.3 0.3 0.0 0.0 0.0 0.0 0.0 22.8 0.0 0.1 0.5 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 1.6 0.2 0.0 4.2 0.7 0.0 0.0 4.3 0.0 0.1 55.9 0.0 0.0 0.0 0.1 57.2 0.2 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 2.8 0.0 0.5 0.0 0.5 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.9 3.2 2.7 0.0 0.1 0.0 1.0 0.1 0.0 0.0 NTRK2 TRKB ENSG00000148053 "Neurotrophic receptor tyrosine kinase 2" Q16620 9 84668551-85027054 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, RAS pathway related proteins" "Differentiation, Neurogenesis" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, Epilepsy, FDA approved drug targets, Obesity" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 230.0;thyroid gland: 116.9" "Cell type enhanced" "Detected in many" "Astrocytes: 1144.3;Excitatory neurons: 750.1;Inhibitory neurons: 877.7;Oligodendrocyte precursor cells: 557.9" "Group enriched" "Detected in many" 5 "glioma: 31.6;head and neck cancer: 8.0;lung cancer: 9.8;thyroid cancer: 26.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 8.7;HaCaT: 3.0;RPTEC TERT1: 9.7;SH-SY5Y: 11.2;SuSa: 4.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007637, CAB010346, HPA074873" Enhanced Supported "Plasma membrane" NA NA 20000000 "Cluster 73: Brain - Neuropeptide signaling" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Plasma membrane" "CAB010346: AB_2155274, HPA007637: AB_1080385, HPA074873: " "unprognostic (2.75e-3)" "unprognostic (3.48e-2)" "unprognostic (1.82e-2)" "unprognostic (3.26e-1)" "unprognostic (9.26e-2)" "unprognostic (2.56e-2)" "unprognostic (1.29e-2)" "unprognostic (9.16e-2)" "unprognostic (6.13e-2)" "unprognostic (1.05e-1)" "unprognostic (4.25e-2)" "unprognostic (2.18e-2)" "unprognostic (2.66e-2)" "unprognostic (1.20e-2)" "unprognostic (1.21e-2)" "unprognostic (1.31e-1)" "unprognostic (1.39e-3)" 40.5 2.7 201.9 1.7 177.8 0.1 62.2 133.3 190.6 9.8 69.8 5.9 0.4 3.9 3.9 8.2 5.6 33.3 15.2 173.3 230.0 20.4 1.8 10.0 3.1 119.4 218.9 9.7 34.3 2.5 10.1 1.8 151.7 4.7 3.6 41.2 14.4 19.1 2.9 11.6 1.6 3.3 116.6 10.9 1.9 2.4 222.1 4.0 116.9 13.8 4.3 4.9 12.0 117.7 0.0 0.0 8.7 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 1.4 0.0 0.2 0.0 0.0 3.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 9.7 0.7 0.7 11.2 0.0 0.0 0.0 4.9 0.0 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.1 0.0 0.3 0.0 2.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 201.9 177.8 133.3 190.6 173.3 230.0 119.4 218.9 151.7 116.6 222.1 117.7 17.4 0.0 0.5 1144.3 0.7 56.6 1.0 1.8 93.9 30.3 144.1 116.8 11.4 0.0 0.2 9.2 6.2 0.0 1.0 8.7 27.4 36.1 1.8 1.2 0.4 8.0 0.0 0.0 750.1 0.7 0.1 76.6 0.0 2.3 0.0 0.1 5.0 0.0 0.2 242.3 877.7 0.7 0.0 0.0 14.2 3.6 104.1 1.4 17.8 65.6 0.6 241.0 0.0 557.9 109.5 0.5 7.0 48.2 0.3 0.9 0.0 7.1 1.7 12.2 124.9 9.9 114.4 0.8 2.3 5.2 24.6 0.0 3.3 0.2 7.2 0.9 NTRK3 TRKC ENSG00000140538 "Neurotrophic receptor tyrosine kinase 3" Q16288 15 87859751-88256768 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Differentiation, Neurogenesis" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 38.8" "Cell type enhanced" "Detected in many" "Astrocytes: 239.3;Early spermatids: 119.6;Excitatory neurons: 360.0;Inhibitory neurons: 277.8;Late spermatids: 148.9;Microglial cells: 177.1;Oligodendrocyte precursor cells: 499.6" "Group enriched" "Detected in some" 4 "glioma: 2.5;testis cancer: 1.0" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 8 "U-138 MG: 100.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009233, HPA027484, HPA048065" Approved Supported "Nuclear membrane,Nucleoli,Nucleoli rim" NA NA 19000000 "Cluster 10: Brain - Neuronal signaling" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoli, Nucleoli rim" "Nuclear membrane" "CAB009233: AB_632555, HPA027484: AB_2672297, HPA048065: AB_2680245" "unprognostic (1.27e-3)" "unprognostic (1.24e-2)" "unprognostic (1.98e-2)" "unprognostic (2.04e-2)" "unprognostic (1.65e-1)" "unprognostic (3.34e-1)" "unprognostic (3.18e-2)" "unprognostic (2.23e-2)" "unprognostic (2.34e-1)" "unprognostic (3.91e-1)" "unprognostic (2.88e-1)" "unprognostic (1.09e-1)" "unprognostic (5.78e-3)" "unprognostic (6.45e-3)" "unprognostic (1.06e-2)" "unprognostic (1.26e-2)" "unprognostic (2.49e-3)" 12.8 3.7 31.3 0.8 33.2 0.1 7.8 30.7 34.3 12.8 0.0 3.4 0.5 10.4 3.2 1.3 15.0 1.6 5.8 38.8 25.8 5.1 1.0 5.3 1.2 21.5 19.6 7.2 1.0 0.1 12.2 1.0 22.1 9.0 2.0 5.2 6.8 4.3 1.8 4.8 2.2 3.7 10.9 2.5 3.2 9.8 33.4 1.2 3.0 1.9 2.0 8.7 7.4 21.5 0.0 13.1 2.7 0.3 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.0 0.2 0.0 0.0 0.3 0.0 0.0 0.0 0.0 1.0 0.0 0.2 0.3 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.0 0.3 0.0 0.0 0.0 0.2 0.1 0.0 0.1 0.0 2.5 0.0 0.0 0.0 2.6 0.1 0.1 0.1 0.7 0.1 0.0 0.0 0.0 0.9 0.1 0.1 0.0 100.6 1.8 0.0 1.3 0.0 0.0 0.0 3.0 0.1 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 31.3 33.2 30.7 34.3 38.8 25.8 21.5 19.6 22.1 10.9 33.4 21.5 0.5 0.0 0.0 239.3 0.0 0.5 6.4 0.0 0.0 53.8 3.7 6.0 5.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 119.6 0.4 25.0 1.2 0.0 0.0 360.0 0.0 0.0 5.7 0.0 0.5 0.0 0.0 2.2 0.0 1.0 1.7 277.8 0.0 0.0 0.0 0.6 148.9 3.4 0.6 0.0 177.1 0.0 8.6 0.0 499.6 7.4 0.0 0.0 27.4 0.0 1.3 0.0 0.1 0.0 3.7 52.6 20.3 40.9 11.0 3.7 0.0 0.1 0.1 0.2 0.0 0.0 0.7 NUAK1 "ARK5, KIAA0537" ENSG00000074590 "NUAK family kinase 1" O60285 12 106063345-106138954 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell adhesion, DNA damage" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Endothelial cells: 111.7;Excitatory neurons: 150.5;Hepatic stellate cells: 136.3;Microglial cells: 93.7;Oligodendrocytes: 73.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 58.0;EFO-21: 55.1;RH-30: 77.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA057143 Approved "Nucleoplasm,Nucleoli fibrillar center,Microtubules" Yes No "Cluster 47: Non-specific - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoli fibrillar center" "Nucleoplasm, Microtubules" "HPA057143: AB_2683349" "unprognostic (4.20e-2)" "unprognostic (8.42e-2)" "unprognostic (3.71e-2)" "prognostic unfavorable (9.83e-4)" "unprognostic (4.13e-2)" "unprognostic (2.34e-1)" "unprognostic (1.43e-1)" "unprognostic (4.80e-2)" "unprognostic (9.91e-2)" "unprognostic (4.06e-3)" "unprognostic (3.29e-1)" "unprognostic (1.31e-1)" "unprognostic (1.93e-3)" "prognostic unfavorable (4.27e-4)" "unprognostic (2.31e-1)" "unprognostic (8.70e-2)" "unprognostic (4.47e-2)" 17.5 3.6 12.6 2.3 17.5 0.6 12.1 9.4 25.4 9.8 0.0 4.1 2.2 9.5 3.1 3.5 9.0 4.9 18.8 17.4 5.6 4.2 4.0 9.3 3.2 6.1 5.9 6.1 3.2 17.5 2.7 4.5 8.3 6.0 3.9 5.4 3.4 6.0 20.6 20.8 4.3 10.2 5.5 0.8 3.8 2.6 5.5 3.3 4.3 17.2 2.3 4.8 8.1 31.8 13.0 8.3 58.0 0.6 23.7 2.5 27.0 14.2 9.5 9.9 8.0 4.3 2.1 0.0 55.1 27.4 5.0 11.9 12.6 11.2 4.8 0.2 3.4 0.0 9.7 4.7 5.0 0.1 0.1 11.0 8.1 6.0 1.7 19.2 21.2 0.1 0.0 40.3 7.8 1.3 0.2 0.6 11.1 0.2 3.3 0.1 77.7 10.5 6.6 13.3 6.8 0.4 6.9 1.9 0.5 37.2 2.9 0.4 16.6 9.4 29.7 3.3 17.0 0.0 0.0 0.7 2.8 0.0 9.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 12.6 17.5 9.4 25.4 17.4 5.6 6.1 5.9 8.3 5.5 5.5 31.8 56.4 0.0 2.4 15.7 0.6 13.5 32.9 29.8 10.2 32.3 2.1 4.2 48.9 10.0 7.2 7.3 0.0 0.8 13.5 0.9 3.9 6.2 0.4 5.1 6.6 111.7 0.0 5.3 150.5 9.6 5.2 17.9 2.0 3.8 0.0 2.9 136.3 12.1 8.0 40.4 55.4 2.3 12.2 8.4 8.8 2.6 4.1 1.3 10.6 93.7 0.6 1.9 1.0 15.6 73.5 18.4 0.5 3.0 3.2 10.6 0.2 1.8 2.2 2.9 0.0 7.1 26.4 1.0 5.5 2.5 15.9 0.3 2.7 0.4 0.8 5.2 NUAK2 "FLJ90349, SNARK" ENSG00000163545 "NUAK family kinase 2" Q9H093 1 205302063-205321745 "Enzymes, Metabolic proteins, Predicted membrane proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 56.7;vagina: 45.3" "Cell type enhanced" "Detected in many" "Ductal cells: 46.9;Endometrial ciliated cells: 45.3;Glandular and luminal cells: 52.4;Intestinal goblet cells: 43.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 120.4" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BEWO: 44.1;RPMI-8226: 36.1;RPTEC TERT1: 40.9;SuSa: 45.6" "Low region specificity" "Detected in many" "Not detected" "Not detected" HPA008958 Uncertain Approved Nucleoplasm,Cytosol NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 44: Endometrium - Transcription" "Nucleoplasm, Cytosol" "HPA008958: AB_1080040" "unprognostic (2.24e-2)" "unprognostic (6.33e-2)" "unprognostic (1.17e-1)" "prognostic unfavorable (3.01e-7)" "unprognostic (8.24e-3)" "unprognostic (1.58e-2)" "unprognostic (3.00e-2)" "unprognostic (1.08e-2)" "unprognostic (1.74e-1)" "unprognostic (9.19e-2)" "prognostic favorable (7.94e-6)" "unprognostic (3.71e-2)" "unprognostic (3.17e-2)" "unprognostic (4.90e-2)" "unprognostic (5.80e-2)" "unprognostic (4.54e-2)" "unprognostic (1.61e-1)" 2.1 3.7 1.3 7.7 1.9 11.4 0.9 4.6 1.7 31.0 3.2 8.0 16.5 1.6 1.3 56.7 4.0 1.7 1.2 1.2 1.3 28.2 5.1 10.3 11.5 2.1 1.8 1.3 16.0 0.8 3.0 4.4 2.0 1.9 8.8 0.5 15.1 1.6 0.7 22.4 12.5 1.2 1.4 13.1 2.5 3.7 2.2 3.9 16.1 1.1 8.0 3.1 45.3 4.1 4.3 23.1 13.7 0.6 0.3 0.6 44.1 5.5 5.7 14.7 5.9 24.4 0.8 7.0 3.2 1.5 24.1 8.3 3.2 8.3 6.3 0.0 0.4 0.0 1.4 4.2 9.3 0.0 0.1 2.6 6.1 8.6 5.0 3.3 0.7 0.0 0.9 1.7 2.8 1.0 0.0 0.1 8.9 3.1 0.7 0.0 1.0 36.1 40.9 0.1 2.1 0.2 1.6 6.5 0.7 45.6 6.6 0.1 1.7 5.3 2.5 0.6 8.7 12.1 2.0 4.4 0.8 0.0 2.1 11.2 16.5 40.1 10.3 11.8 7.6 37.9 12.7 12.3 10.4 39.3 27.9 21.9 120.4 17.5 13.1 4.1 8.1 17.4 1.3 1.9 4.6 1.7 1.2 1.3 2.1 1.8 2.0 1.4 2.2 4.1 2.0 6.4 6.8 0.3 28.0 1.1 3.2 3.7 13.1 1.1 1.9 2.2 2.7 20.0 2.9 33.1 0.0 9.2 7.1 34.9 5.9 46.9 2.0 45.3 7.5 5.9 10.8 2.7 0.1 1.8 29.1 3.7 7.7 52.4 0.0 2.4 0.7 2.6 4.7 0.0 0.4 43.0 18.3 12.3 11.1 2.1 0.0 8.9 7.2 3.7 38.5 1.3 18.6 0.5 3.5 6.9 7.8 0.0 18.5 2.5 18.3 17.2 7.7 0.5 6.6 2.4 5.5 0.9 1.1 21.5 5.4 4.1 5.7 0.5 22.0 0.5 NUDT5 "hYSAH1, YSA1H" ENSG00000165609 "Nudix hydrolase 5" Q9UKK9 10 12165330-12196144 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019827 Approved Approved Nucleoplasm,Vesicles,Centrosome NA NA 1500000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 64: Macrophages - Immune response" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" Vesicles "Nucleoplasm, Centrosome" "HPA019827: AB_1854704" "unprognostic (2.08e-2)" "unprognostic (2.10e-1)" "unprognostic (1.61e-1)" "unprognostic (2.09e-1)" "unprognostic (3.77e-3)" "unprognostic (4.91e-2)" "unprognostic (2.54e-2)" "unprognostic (4.60e-2)" "unprognostic (1.32e-1)" "unprognostic (6.39e-3)" "unprognostic (2.06e-1)" "unprognostic (9.97e-2)" "prognostic unfavorable (7.14e-12)" "unprognostic (1.61e-1)" "unprognostic (1.33e-1)" "unprognostic (3.12e-2)" "unprognostic (3.68e-2)" 35.1 32.4 23.0 30.6 26.4 24.1 26.7 27.5 30.5 24.6 29.5 32.0 27.5 14.3 23.7 40.7 24.6 18.4 14.9 23.4 26.0 36.3 88.8 26.0 39.3 27.3 24.9 18.0 25.9 33.1 35.5 31.1 27.4 21.0 36.0 27.4 25.1 14.0 6.2 33.2 25.4 17.6 25.0 34.2 22.6 13.1 25.4 53.5 27.8 7.6 47.4 28.9 27.8 31.8 136.4 98.0 114.6 107.1 107.5 105.6 100.8 96.9 61.5 111.9 119.1 142.5 125.9 134.2 82.4 79.2 70.0 133.1 162.0 150.6 102.1 110.8 160.8 111.9 114.3 209.3 112.0 77.1 75.2 111.7 88.4 122.3 61.7 86.3 144.9 209.4 153.5 88.9 103.2 123.8 143.5 87.0 100.4 215.0 60.1 128.0 42.4 157.2 106.0 46.1 56.6 82.3 117.4 90.8 142.2 132.0 155.9 77.9 91.6 47.0 90.6 134.3 121.9 74.3 141.6 179.3 99.7 97.3 36.0 29.6 60.8 115.2 69.9 65.7 80.4 72.7 73.9 82.6 87.6 64.6 50.4 68.4 163.8 57.4 52.2 149.2 123.4 71.6 23.0 26.4 27.5 30.5 23.4 26.0 27.3 24.9 27.4 25.0 25.4 31.8 42.1 25.6 55.1 23.2 43.8 43.0 57.8 121.2 28.5 21.1 28.6 30.7 4.5 32.9 72.3 23.9 16.7 82.6 49.8 35.0 74.3 82.2 35.3 61.1 44.4 42.6 38.3 43.5 34.6 82.9 150.6 40.3 33.1 31.9 31.7 41.4 41.7 131.8 128.7 21.9 38.2 41.2 79.3 41.8 32.2 11.7 39.4 39.7 30.2 12.2 85.0 37.4 62.8 34.2 41.2 73.8 35.2 29.0 66.1 33.7 52.6 130.6 103.9 25.5 32.9 21.2 40.1 20.2 33.6 52.4 60.5 58.1 49.7 54.4 57.4 46.9 NUS1 "C6orf68, MGC7199, NgBR, TANGO14" ENSG00000153989 "NUS1 dehydrodolichyl diphosphate synthase subunit" Q96E22 6 117675469-117710727 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted membrane proteins" "Angiogenesis, Differentiation, Lipid metabolism" "Developmental protein, Receptor, Transferase" "Congenital disorder of glycosylation, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027504 Supported Approved "Vesicles,Plasma membrane" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 29: Non-specific - Vesicular transport" "Cluster 1: K-562 - Erythropoiesis" "Cluster 55: Plasma cells - Humoral immune response" Vesicles "Plasma membrane" "HPA027504: AB_10603124" "unprognostic (1.21e-2)" "prognostic unfavorable (6.99e-4)" "unprognostic (1.09e-2)" "unprognostic (2.31e-1)" "unprognostic (1.21e-1)" "unprognostic (8.26e-3)" "unprognostic (1.42e-3)" "unprognostic (2.42e-2)" "unprognostic (8.62e-2)" "unprognostic (2.99e-1)" "unprognostic (2.62e-1)" "unprognostic (8.35e-2)" "unprognostic (1.00e-1)" "unprognostic (2.27e-1)" "unprognostic (3.22e-2)" "unprognostic (1.56e-1)" "unprognostic (7.97e-2)" 17.8 20.0 12.1 22.2 13.0 19.4 22.2 11.4 15.5 60.3 16.1 19.8 16.5 20.6 28.4 15.7 18.4 16.1 11.7 12.9 13.8 28.4 31.6 18.2 21.4 10.8 12.5 16.5 20.4 29.8 11.9 21.6 11.9 20.6 20.3 12.5 30.5 17.6 10.0 11.1 17.6 18.7 11.7 17.8 24.2 12.6 13.5 18.5 35.4 12.6 20.6 23.5 11.7 12.4 27.1 19.5 41.3 46.4 40.7 52.9 101.0 48.3 50.1 39.5 45.1 44.6 29.5 63.4 51.1 44.7 50.0 24.0 62.1 47.2 73.0 47.9 57.0 72.8 31.5 80.2 62.6 92.8 41.2 46.6 52.5 43.3 87.7 40.3 41.3 46.5 88.4 54.9 59.7 30.5 43.9 58.8 48.0 36.9 35.3 41.7 29.7 45.7 79.0 26.6 48.7 38.5 29.1 37.4 36.9 45.6 23.8 95.9 36.4 24.3 30.1 39.2 70.5 75.6 60.8 66.8 57.6 70.0 49.7 1.9 1.3 0.8 1.3 1.4 1.9 1.1 1.6 1.8 1.5 1.0 1.3 1.7 0.1 1.9 2.5 3.8 1.7 1.0 12.1 13.0 11.4 15.5 12.9 13.8 10.8 12.5 11.9 11.7 13.5 12.4 18.7 0.0 22.3 30.3 28.5 60.5 41.9 32.6 19.4 15.3 26.6 13.7 6.3 15.7 24.0 25.8 10.4 26.8 38.1 26.4 27.4 23.4 16.0 15.7 28.9 24.3 13.1 19.1 33.4 30.2 63.6 22.8 38.2 21.4 31.1 15.8 28.2 39.7 35.3 15.2 37.1 29.3 20.3 37.0 42.2 14.0 18.0 30.2 32.0 20.6 28.4 8.3 24.7 35.7 36.5 37.4 22.7 20.3 57.5 73.1 18.6 33.6 23.1 9.6 6.6 21.3 25.9 24.9 25.4 25.7 56.1 57.9 26.2 14.5 26.1 77.5 OAS1 "IFI-4, OIAS, OIASI" ENSG00000089127 "2'-5'-oligoadenylate synthetase 1" P00973 12 112905856-112933219 "Enzymes, Predicted intracellular proteins" "Antiviral defense, Immunity, Innate immunity" "Nucleotidyltransferase, RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "salivary gland: 91.0;urinary bladder: 111.1" "Cell type enhanced" "Detected in many" "Distal enterocytes: 151.0;Hofbauer cells: 105.6;Paneth cells: 127.9;Urothelial cells: 171.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "non-classical monocyte: 572.0" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BJ hTERT+ SV40 Large T+: 247.1;BJ hTERT+ SV40 Large T+ RasG12V: 336.6;OE19: 307.6;U-266/70: 272.9;U-266/84: 210.3" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA003657, CAB021104" Uncertain Supported Nucleoplasm,Cytosol "Intracellular and membrane" NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 37: Intestine - Unknown function" "Cluster 21: OE19 - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoplasm, Cytosol" "CAB021104: AB_10057722, HPA003657: AB_1854747" "unprognostic (1.03e-1)" "unprognostic (6.59e-2)" "unprognostic (8.56e-3)" "unprognostic (2.20e-3)" "unprognostic (2.78e-1)" "unprognostic (1.30e-1)" "unprognostic (2.00e-2)" "unprognostic (3.16e-2)" "unprognostic (1.37e-1)" "unprognostic (2.20e-2)" "prognostic unfavorable (3.02e-4)" "unprognostic (5.37e-2)" "unprognostic (1.63e-2)" "unprognostic (6.91e-2)" "unprognostic (3.68e-2)" "unprognostic (5.67e-2)" "prognostic favorable (6.12e-6)" 17.0 11.5 6.8 27.3 7.3 14.3 13.1 6.5 9.7 29.6 6.1 49.0 51.7 8.0 8.1 57.1 10.0 22.5 9.5 6.6 6.9 22.3 38.6 23.1 27.2 15.4 8.0 8.1 4.4 9.0 8.3 20.4 11.5 9.1 45.1 1.5 91.0 7.3 2.4 10.3 39.8 14.6 21.2 50.5 43.6 4.8 8.4 28.1 7.7 7.4 25.6 111.1 22.7 9.9 4.7 24.4 0.0 0.1 9.4 6.6 1.5 0.1 38.8 247.1 336.6 18.5 34.1 42.3 12.2 0.3 121.8 10.8 0.2 4.2 2.2 21.0 0.0 0.7 35.2 4.6 2.9 0.6 1.4 0.5 7.2 8.0 0.0 3.1 13.5 0.7 0.0 17.4 0.2 0.4 0.6 17.0 0.7 307.6 22.5 5.8 0.2 20.5 11.6 89.4 0.2 0.9 3.7 4.2 85.2 0.4 0.9 5.1 50.4 0.0 0.5 3.2 0.4 272.9 210.3 23.9 2.9 6.6 1.4 6.3 253.6 3.2 26.5 403.9 25.3 108.8 36.3 34.3 153.9 93.1 14.3 18.8 24.4 24.9 572.0 144.5 108.7 217.8 6.8 7.3 6.5 9.7 6.6 6.9 15.4 8.0 11.5 21.2 8.4 9.9 23.0 3.2 2.2 0.0 21.1 3.4 16.6 24.0 10.8 0.2 6.0 8.1 3.1 14.3 35.4 5.5 0.0 12.6 31.5 151.0 5.9 19.5 0.4 1.9 3.6 17.2 4.2 3.6 0.6 12.0 36.4 11.1 28.5 4.1 5.1 15.4 14.3 11.9 105.6 0.0 1.0 59.3 26.4 36.9 11.4 1.2 7.2 52.9 5.4 13.1 36.2 15.0 18.6 3.5 0.1 19.5 127.9 10.5 24.1 7.4 50.9 25.4 17.5 0.4 6.6 3.0 7.5 0.0 0.5 18.3 2.3 5.7 9.1 12.7 14.6 171.9 OAS2 ENSG00000111335 "2'-5'-oligoadenylate synthetase 2" P29728 12 112978395-113011723 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Antiviral defense, Immunity, Innate immunity" "Nucleotidyltransferase, RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "salivary gland: 67.2" "Cell type enhanced" "Detected in many" "Adipocytes: 22.8;Endothelial cells: 21.4;Macrophages: 27.6;monocytes: 26.1;NK-cells: 26.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BJ hTERT+ SV40 Large T+: 364.3;BJ hTERT+ SV40 Large T+ RasG12V: 297.5;Daudi: 88.7;SK-MEL-30: 135.0;U-266/70: 118.4;U-266/84: 115.4" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA003320, CAB024984" Approved Approved Centrosome NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 16: Immune cells - Immune response" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Centrosome "CAB024984: , HPA003320: " "unprognostic (2.39e-1)" "unprognostic (9.51e-2)" "unprognostic (2.13e-2)" "unprognostic (1.15e-2)" "unprognostic (1.34e-1)" "unprognostic (7.94e-2)" "unprognostic (4.79e-2)" "unprognostic (2.05e-2)" "unprognostic (1.31e-1)" "unprognostic (7.64e-3)" "prognostic unfavorable (4.63e-4)" "unprognostic (4.20e-1)" "prognostic unfavorable (4.31e-6)" "unprognostic (1.12e-1)" "unprognostic (4.17e-2)" "unprognostic (1.11e-1)" "unprognostic (1.94e-2)" 11.9 4.3 5.1 25.7 5.5 15.1 7.2 5.6 7.9 9.8 4.6 8.6 9.3 6.2 2.9 13.4 6.2 17.8 8.7 5.1 5.0 5.8 19.6 26.3 38.0 10.6 6.4 2.1 1.6 2.8 2.3 23.4 8.0 7.2 9.0 1.0 67.2 3.6 2.5 2.7 9.1 12.9 12.0 43.5 18.5 3.8 6.0 36.7 5.2 6.9 33.1 22.8 5.6 6.5 3.0 0.5 0.2 0.2 1.7 12.3 0.2 0.5 41.9 364.3 297.5 0.6 5.9 88.7 8.4 6.9 71.3 3.4 0.8 0.9 12.1 22.8 0.2 0.2 0.8 0.5 2.5 0.1 0.2 0.8 6.0 19.7 0.0 0.3 5.2 4.2 0.1 42.2 0.2 1.2 2.4 4.2 0.1 0.4 12.4 20.5 0.1 13.5 0.1 31.2 0.1 0.1 3.3 0.6 135.0 0.2 2.6 5.4 8.1 0.6 0.1 1.1 0.3 118.4 115.4 13.6 2.6 4.5 2.7 3.9 35.5 2.7 25.6 55.6 33.5 24.3 30.0 29.6 26.9 15.5 28.9 21.7 3.6 32.1 60.2 11.5 35.4 30.9 5.1 5.5 5.6 7.9 5.1 5.0 10.6 6.4 8.0 12.0 6.0 6.5 22.8 3.2 6.0 0.3 16.6 2.0 1.6 4.0 2.8 0.1 2.1 1.3 1.6 0.0 5.1 1.8 0.0 0.2 15.1 1.2 0.0 1.0 0.7 3.5 3.4 21.4 0.0 4.0 0.2 1.2 2.4 4.8 6.1 1.7 1.3 2.5 12.1 2.6 16.1 0.0 0.5 3.8 0.0 19.7 4.7 1.2 0.6 27.6 5.4 10.3 26.1 0.4 26.8 2.0 0.1 3.8 1.2 3.4 15.5 2.6 0.4 0.3 12.2 0.2 0.0 1.0 2.7 0.1 0.1 7.6 1.1 0.1 15.5 6.0 0.4 10.4 OAS3 ENSG00000111331 "2'-5'-oligoadenylate synthetase 3" Q9Y6K5 12 112938051-112976460 "Enzymes, Predicted intracellular proteins" "Antiviral defense, Immunity, Innate immunity" "Nucleotidyltransferase, RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "monocytes: 30.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "non-classical monocyte: 15.3" "Low lineage specificity" "Detected in all" "Group enriched" "Detected in many" 4 "BJ hTERT+ SV40 Large T+: 202.5;BJ hTERT+ SV40 Large T+ RasG12V: 224.5;GAMG: 89.8;RT4: 62.6" "Not detected" "Not detected" "HPA041253, HPA041372" Uncertain Supported "Nucleoplasm,Plasma membrane,Cytosol" Yes No 21000 "Cluster 51: Monocytes - Innate immune response" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Nucleoplasm, Cytosol" "Plasma membrane" "HPA041253: AB_10794990, HPA041372: AB_10795590" "unprognostic (8.47e-2)" "unprognostic (9.13e-2)" "unprognostic (1.27e-2)" "unprognostic (4.39e-3)" "unprognostic (2.59e-2)" "unprognostic (1.45e-1)" "unprognostic (4.14e-3)" "unprognostic (8.06e-3)" "unprognostic (3.19e-1)" "unprognostic (1.73e-2)" "unprognostic (2.29e-3)" "unprognostic (2.48e-1)" "prognostic unfavorable (2.23e-5)" "unprognostic (4.25e-2)" "unprognostic (1.37e-2)" "unprognostic (3.29e-2)" "unprognostic (2.93e-2)" 8.1 4.1 3.2 11.5 3.1 20.9 6.0 2.3 2.5 11.0 1.1 7.1 7.1 3.9 1.5 15.8 5.2 11.3 7.0 2.2 2.4 5.6 4.4 12.6 6.0 8.7 3.6 3.8 3.8 3.2 3.5 11.1 6.4 3.4 6.2 0.6 27.7 2.7 3.0 5.4 6.5 9.3 11.8 17.9 11.0 2.3 4.1 16.1 4.1 5.9 6.4 14.4 7.8 3.0 23.2 34.4 0.3 5.5 1.0 4.6 2.1 2.6 25.3 202.5 224.5 24.1 20.5 0.7 7.3 8.1 89.8 15.7 3.3 22.7 11.2 9.7 1.2 15.9 16.3 4.0 3.9 4.5 6.6 0.9 7.2 32.8 1.3 4.0 11.7 3.9 0.5 3.1 2.0 13.3 8.0 2.7 1.4 33.7 22.8 13.5 11.6 0.1 7.0 62.6 0.6 0.1 19.8 5.5 14.8 0.2 25.7 1.1 9.5 4.6 4.0 5.5 6.5 0.8 21.0 0.2 4.9 12.9 16.7 1.0 7.8 0.8 1.4 7.4 1.7 2.3 2.0 2.3 4.1 1.0 1.8 1.7 9.7 2.7 15.3 0.3 2.6 3.5 3.2 3.1 2.3 2.5 2.2 2.4 8.7 3.6 6.4 11.8 4.1 3.0 19.9 3.2 3.9 0.7 3.8 3.4 5.6 13.5 5.2 0.4 3.1 2.7 1.7 0.0 5.1 3.7 0.0 5.4 1.8 14.7 3.9 11.2 5.9 1.8 4.1 20.8 1.8 0.8 0.3 9.8 20.9 5.5 16.3 5.6 1.3 21.9 9.3 1.7 18.7 0.0 0.4 6.8 8.2 5.8 7.0 10.8 10.2 16.7 1.8 5.6 30.2 3.0 8.2 3.5 0.0 21.2 8.2 15.1 1.4 11.8 4.5 2.0 2.3 0.5 0.0 2.5 5.0 0.8 0.7 14.4 4.7 1.9 6.5 9.2 5.4 26.8 OAT HOGA ENSG00000065154 "Ornithine aminotransferase" P04181 10 124397303-124418976 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Aminotransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 781.8" "Cell type enhanced" "Detected in all" "Proximal enterocytes: 1222.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033576, HPA040098, HPA064742" Enhanced Supported Nucleoplasm,Mitochondria NA NA 12000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 56: Intestine - Transmembrane transport" "Cluster 1: K-562 - Erythropoiesis" "Cluster 45: Enterocytes - Digestion" Mitochondria Nucleoplasm "CAB033576: AB_2298892, HPA040098: AB_10793955, HPA064742: AB_2685343" "unprognostic (1.61e-2)" "unprognostic (1.70e-2)" "unprognostic (9.96e-2)" "unprognostic (1.02e-2)" "unprognostic (1.34e-1)" "unprognostic (1.05e-1)" "unprognostic (2.03e-1)" "unprognostic (4.43e-3)" "unprognostic (1.65e-1)" "unprognostic (2.37e-2)" "unprognostic (2.45e-1)" "unprognostic (7.62e-2)" "unprognostic (1.70e-2)" "unprognostic (2.21e-1)" "unprognostic (2.19e-1)" "unprognostic (2.72e-2)" "unprognostic (2.00e-2)" 60.0 119.6 69.4 40.8 71.2 106.4 150.1 74.6 97.4 99.7 75.4 75.6 750.0 82.5 63.7 105.0 56.0 68.7 52.3 71.2 78.7 114.6 162.5 42.7 38.1 76.5 72.0 77.0 36.1 46.1 53.5 65.0 85.2 74.3 67.2 51.1 225.4 94.6 58.2 71.6 781.8 97.8 73.6 34.1 70.1 56.2 73.3 30.2 67.7 60.0 69.1 58.9 63.8 81.7 241.5 42.8 27.5 98.7 272.4 260.8 93.4 142.2 288.0 124.2 135.2 110.5 30.8 0.5 101.0 241.8 118.0 249.4 126.5 265.7 134.0 42.4 174.9 268.1 28.1 82.7 139.9 0.4 169.3 172.1 134.5 111.9 129.5 204.9 147.1 48.4 470.8 50.0 175.5 62.6 72.1 15.3 55.1 73.2 59.6 66.3 104.5 65.3 119.8 3.9 57.3 60.9 89.7 235.1 209.5 156.6 78.6 65.8 114.3 70.5 65.3 117.9 90.2 42.4 47.6 64.6 97.4 72.0 34.4 38.0 39.6 36.0 28.8 35.3 31.2 15.2 24.0 30.5 44.3 16.2 29.5 29.8 40.0 16.9 37.2 9.4 24.6 29.6 69.4 71.2 74.6 97.4 71.2 78.7 76.5 72.0 85.2 73.6 73.3 81.7 49.0 19.2 49.7 37.9 44.7 151.3 144.0 362.8 185.5 35.2 154.2 163.7 21.8 18.6 182.7 35.0 27.1 120.8 80.3 38.2 90.1 34.6 30.4 37.0 90.4 37.7 43.1 317.0 31.8 13.4 90.5 124.2 55.5 40.6 43.8 32.2 37.5 152.2 66.2 43.7 33.4 104.1 197.4 31.8 68.1 15.2 104.1 56.7 85.4 17.8 34.8 37.4 18.6 22.1 41.9 12.6 74.6 120.0 32.9 82.6 1222.6 196.4 76.4 24.4 78.9 106.1 115.1 46.3 33.2 161.8 126.0 48.2 65.0 92.4 214.5 82.2 OBI1 "C13orf7, FLJ13449, RNF219" ENSG00000152193 "ORC ubiquitin ligase 1" Q5W0B1 13 78614289-78659155 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in some" "Adipocytes: 14.5;Cardiomyocytes: 19.5;Cytotrophoblasts: 15.8;dendritic cells: 8.0;Extravillous trophoblasts: 12.2;Hofbauer cells: 9.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034785, HPA034786" Enhanced Approved "Nucleoplasm,Nuclear bodies,Cytosol" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 32: U-937 - Innate immune response" "Cluster 24: Non-specific - Transcription regulation" "Nucleoplasm, Nuclear bodies" Cytosol "HPA034785: AB_10601496, HPA034786: AB_2674331" "unprognostic (2.99e-1)" "unprognostic (1.11e-1)" "unprognostic (1.79e-1)" "unprognostic (2.60e-1)" "unprognostic (7.88e-2)" "unprognostic (1.34e-2)" "unprognostic (2.83e-3)" "unprognostic (1.50e-1)" "unprognostic (1.67e-2)" "unprognostic (1.45e-1)" "unprognostic (3.84e-2)" "unprognostic (4.26e-3)" "prognostic unfavorable (4.99e-6)" "unprognostic (6.87e-2)" "unprognostic (2.01e-1)" "unprognostic (6.91e-2)" "unprognostic (2.53e-2)" 5.8 4.8 5.4 6.1 5.8 2.4 6.7 6.6 6.7 5.9 3.0 4.8 4.8 7.1 4.5 5.0 5.6 4.5 7.1 5.6 6.1 4.6 4.4 5.2 9.9 5.5 5.9 7.6 4.1 4.1 2.9 7.4 5.0 5.5 5.3 9.6 4.2 6.1 4.8 5.5 4.7 6.5 6.1 7.3 4.5 14.8 7.2 13.3 5.9 6.4 11.3 6.0 4.5 5.9 23.7 9.1 39.1 23.1 13.5 12.9 17.8 19.3 14.5 18.7 23.3 18.3 17.3 39.8 9.2 12.4 12.2 23.0 31.2 15.3 32.6 24.9 22.8 61.0 11.4 16.1 11.3 59.6 18.2 12.4 16.7 15.7 16.8 10.6 15.6 19.9 16.1 5.3 24.6 6.6 36.5 20.2 0.0 25.1 10.0 42.0 32.2 15.4 12.7 12.5 28.4 15.9 13.4 16.9 14.8 22.2 8.6 47.3 12.9 16.2 14.7 10.7 16.3 5.5 6.6 37.9 25.9 35.6 17.8 4.9 5.4 7.5 7.9 8.8 9.5 8.8 8.8 9.8 6.3 8.9 10.8 9.8 1.8 11.1 10.3 5.3 9.6 6.6 5.4 5.8 6.6 6.7 5.6 6.1 5.5 5.9 5.0 6.1 7.2 5.9 14.5 0.0 0.0 0.0 2.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.5 0.0 0.0 0.0 0.0 15.8 8.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 12.2 4.9 0.0 0.0 0.0 0.0 0.0 0.0 9.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 5.1 1.1 0.0 0.0 0.0 OBSCN "ARHGEF30, KIAA1556, KIAA1639, UNC89" ENSG00000154358 "Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF" Q5VST9 1 228208044-228378876 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Differentiation "Calmodulin-binding, Developmental protein, Kinase, Muscle protein, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 4 "skeletal muscle: 481.3" "Cell type enriched" "Detected in many" 6 "Cardiomyocytes: 155.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HeLa: 10.5" "Low region specificity" "Detected in single" "Low region specificity" "Detected in many" "HPA021186, HPA065801" Enhanced Approved "Plasma membrane,Cytosol" NA NA 4500000 "Cluster 7: Monocytes - Unknown function" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 20: HeLa - Mitochondria" "Cluster 37: Myocytes - Muscle contraction" "Plasma membrane, Cytosol" "HPA021186: AB_1854761, HPA065801: " "unprognostic (8.47e-3)" "unprognostic (1.56e-1)" "unprognostic (9.99e-2)" "prognostic unfavorable (1.64e-4)" "unprognostic (5.30e-3)" "unprognostic (6.36e-2)" "unprognostic (4.54e-3)" "unprognostic (1.82e-1)" "unprognostic (8.81e-2)" "unprognostic (1.93e-2)" "unprognostic (3.38e-1)" "unprognostic (1.45e-1)" "unprognostic (1.57e-3)" "unprognostic (1.34e-1)" "unprognostic (1.77e-1)" "unprognostic (3.53e-1)" "unprognostic (1.16e-2)" 3.5 2.5 2.4 1.4 18.4 1.6 3.7 10.4 4.4 8.1 18.1 5.2 0.7 3.7 1.8 4.6 5.1 1.1 78.5 0.9 2.7 6.6 1.3 8.9 2.1 4.3 2.7 8.6 5.4 1.1 13.6 0.9 2.4 9.9 0.5 0.8 9.4 1.7 481.3 4.7 5.4 0.5 1.0 9.3 5.2 1.9 6.3 4.9 7.5 112.8 1.3 3.2 7.4 0.1 1.7 2.8 3.6 3.7 0.2 0.2 4.6 1.6 0.7 1.7 1.4 2.1 1.3 3.2 5.4 0.7 0.7 2.1 1.3 2.2 0.3 2.0 3.4 1.7 10.5 0.1 1.2 2.4 2.2 1.4 0.6 0.4 0.5 5.1 0.5 7.0 3.2 0.0 0.3 1.8 3.3 3.5 4.9 0.6 2.1 4.4 0.0 1.9 1.8 1.4 1.7 6.3 0.6 3.9 1.0 0.8 3.4 4.0 1.0 0.0 5.1 0.3 0.5 2.5 0.5 4.7 0.0 0.8 2.1 0.0 0.1 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.2 0.1 0.3 0.1 0.0 0.0 0.0 0.1 0.1 0.1 2.4 18.4 10.4 4.4 0.9 2.7 4.3 2.7 2.4 1.0 6.3 0.1 1.5 0.0 5.5 1.6 2.4 2.2 6.6 7.7 23.9 4.2 7.3 11.9 155.8 4.3 4.5 5.5 10.4 0.1 1.9 0.7 11.7 3.6 4.9 3.9 3.7 3.1 0.0 3.0 3.9 0.5 0.5 5.7 3.1 11.3 7.0 1.8 1.4 0.5 0.1 0.0 5.3 2.7 4.1 0.3 1.0 4.5 3.1 1.1 1.8 5.6 0.5 7.9 4.1 1.5 1.7 0.8 1.1 4.5 1.5 3.8 0.6 4.1 1.3 3.2 0.0 22.9 6.1 1.0 4.1 9.4 1.7 1.2 5.4 6.2 1.2 3.6 OGT "FLJ23071, HRNT1, MGC22921, O-GLCNAC, OGT1" ENSG00000147162 "O-linked N-acetylglucosamine (GlcNAc) transferase" O15294 X 71533104-71575892 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Biological rhythms, Host-virus interaction, Ubl conjugation pathway" "Chromatin regulator, Glycosyltransferase, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030751, HPA030752, HPA030753, HPA030754, CAB034099" Approved Supported "Nucleoplasm,Plasma membrane" Yes No "Cluster 39: Non-specific - mRNA processing" "Cluster 50: Non-specific - Ribosome" "Cluster 2: Karpas-707 - Immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Nucleoplasm "Plasma membrane" "CAB034099: AB_2157067, HPA030751: AB_10600217, HPA030752: AB_10601445, HPA030753: AB_2673594, HPA030754: AB_2673595" "unprognostic (1.37e-1)" "unprognostic (2.20e-1)" "unprognostic (2.32e-2)" "prognostic unfavorable (8.33e-4)" "unprognostic (3.40e-2)" "prognostic favorable (1.97e-4)" "unprognostic (9.56e-3)" "unprognostic (1.96e-3)" "unprognostic (5.58e-2)" "unprognostic (2.29e-1)" "unprognostic (1.06e-1)" "unprognostic (9.74e-3)" "prognostic unfavorable (2.36e-6)" "unprognostic (2.99e-3)" "unprognostic (2.28e-1)" "unprognostic (8.03e-3)" "prognostic favorable (6.85e-7)" 59.3 55.9 39.7 38.3 42.4 61.5 62.7 43.3 51.6 72.7 40.1 62.5 30.6 56.0 62.2 52.8 76.4 26.4 55.5 43.9 35.5 61.6 45.8 70.7 71.9 36.1 35.8 85.5 102.4 24.3 46.9 26.4 37.9 75.4 39.6 36.9 64.1 27.1 62.8 68.6 86.4 24.5 36.1 122.8 67.4 19.0 36.2 57.2 70.7 39.2 57.8 55.7 67.4 44.3 40.5 37.0 47.1 41.5 49.6 45.6 31.6 30.3 54.3 32.1 49.1 39.3 45.4 47.9 20.7 37.3 33.3 49.1 52.0 29.5 39.4 41.1 53.4 30.4 98.6 28.5 37.6 62.9 48.1 43.6 59.2 35.1 65.7 55.5 30.5 100.7 31.1 160.4 31.1 34.3 48.9 75.2 31.6 35.5 49.8 47.8 52.7 62.1 50.0 45.9 24.1 21.2 46.9 30.9 30.2 35.5 22.8 42.4 35.5 34.6 27.9 36.6 17.9 43.5 33.5 56.5 24.4 65.0 21.6 2.8 4.6 2.0 7.5 5.7 6.8 7.4 6.3 6.2 6.1 6.2 7.2 7.4 1.9 10.4 5.7 6.2 6.2 5.6 39.7 42.4 43.3 51.6 43.9 35.5 36.1 35.8 37.9 36.1 36.2 44.3 31.1 35.3 85.2 52.9 67.2 88.1 37.9 23.5 58.6 26.5 49.6 34.0 42.8 20.0 31.1 49.7 8.4 15.8 130.7 31.1 9.8 14.4 2.4 32.1 49.8 39.8 34.9 51.3 110.7 14.4 8.5 47.5 54.6 53.3 27.8 26.4 45.7 27.5 16.1 40.4 94.6 37.3 22.4 60.9 69.7 4.8 53.4 45.8 35.6 71.2 51.6 11.3 51.5 92.0 97.9 17.6 34.9 29.7 147.2 53.8 34.8 15.1 28.0 21.8 32.9 44.8 42.2 2.5 6.1 63.3 84.1 10.9 82.1 62.0 34.0 50.8 OSGEP "GCPL1, KAE1, OSGEP1, PRSMG1, TCS3" ENSG00000092094 "O-sialoglycoprotein endopeptidase" Q9NPF4 14 20446401-20455089 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "tRNA processing" "Acyltransferase, Transferase" "Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039751 Uncertain Supported "Nucleoplasm,Plasma membrane" NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 52: Non-specific - Ribosome" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 57: B-cells - Immune response" Nucleoplasm "Plasma membrane" "HPA039751: AB_10794754" "prognostic favorable (1.48e-4)" "unprognostic (4.15e-3)" "unprognostic (1.29e-1)" "unprognostic (4.33e-3)" "unprognostic (1.54e-2)" "unprognostic (3.95e-2)" "unprognostic (5.54e-3)" "unprognostic (2.80e-3)" "unprognostic (2.98e-1)" "unprognostic (1.05e-1)" "unprognostic (3.35e-3)" "unprognostic (1.22e-1)" "prognostic unfavorable (4.64e-6)" "unprognostic (4.83e-2)" "unprognostic (1.86e-2)" "unprognostic (2.53e-2)" "unprognostic (9.91e-2)" 5.7 6.3 6.1 3.8 6.2 6.1 7.0 6.4 7.3 6.8 6.8 7.6 3.8 6.4 8.5 6.0 6.1 6.6 8.1 6.0 6.3 5.8 11.1 6.2 9.3 6.4 6.1 5.3 5.6 7.4 5.2 6.7 6.4 4.9 7.0 4.1 5.3 8.3 10.5 4.7 6.2 5.6 6.5 8.4 6.4 2.4 6.3 9.9 7.6 9.9 10.1 8.2 4.9 6.9 10.3 17.2 5.6 16.2 9.9 6.6 17.6 8.0 11.3 21.1 20.1 21.5 12.3 21.1 10.3 11.0 9.0 8.6 17.9 17.6 14.1 16.8 19.1 14.8 12.2 32.1 7.4 24.3 19.7 5.3 5.2 26.1 14.0 4.6 14.3 18.8 14.0 12.1 17.6 21.0 25.0 11.8 9.1 31.5 31.8 35.3 10.3 12.4 12.8 11.7 21.3 4.2 15.4 16.0 11.9 3.3 9.7 23.7 6.1 8.7 21.2 11.3 10.7 3.4 18.0 31.7 5.0 36.1 11.0 9.3 29.2 38.5 18.8 27.9 17.4 28.7 19.7 17.2 44.5 38.1 15.9 17.4 13.8 20.9 23.3 16.9 19.2 24.6 6.1 6.2 6.4 7.3 6.0 6.3 6.4 6.1 6.4 6.5 6.3 6.9 27.1 35.3 34.9 16.3 46.0 11.5 20.9 26.2 14.2 37.8 24.0 25.1 17.2 15.7 29.1 23.9 37.5 66.3 31.8 22.5 35.2 24.7 3.1 19.2 18.3 24.1 26.9 19.6 23.0 29.8 47.0 23.4 28.1 16.3 25.9 24.6 25.7 19.3 65.8 10.1 24.1 24.2 22.4 30.7 32.8 3.0 19.3 34.2 21.4 7.5 28.4 31.0 32.0 16.6 17.0 20.0 30.6 21.4 26.2 10.9 42.2 39.7 25.5 51.5 13.1 24.6 23.9 7.8 16.9 22.0 11.5 46.1 26.8 37.3 31.6 17.4 OSGEPL1 "OSGEPL, Qri7" ENSG00000128694 "O-sialoglycoprotein endopeptidase like 1" Q9H4B0 2 189746660-189763227 "Enzymes, Predicted intracellular proteins" "tRNA processing" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Sertoli cells: 26.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA030693 Uncertain Supported Mitochondria NA NA "Cluster 30: Non-specific - Translation" "Cluster 8: Non-specific - Mitochondria" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 52: Non-specific - Transcription" Mitochondria "HPA030693: AB_10601978" "unprognostic (1.10e-1)" "unprognostic (8.72e-2)" "unprognostic (8.19e-2)" "unprognostic (6.70e-2)" "unprognostic (6.07e-2)" "unprognostic (6.38e-2)" "prognostic unfavorable (3.71e-4)" "unprognostic (4.18e-3)" "unprognostic (1.06e-3)" "prognostic favorable (3.19e-4)" "unprognostic (2.33e-1)" "unprognostic (1.80e-2)" "unprognostic (3.34e-2)" "unprognostic (2.68e-1)" "unprognostic (1.51e-2)" "unprognostic (6.39e-2)" "unprognostic (1.55e-3)" 3.9 8.2 3.6 3.5 5.0 1.9 7.2 6.1 5.0 4.5 3.0 3.5 3.3 5.7 5.6 4.0 5.2 3.2 8.9 3.4 4.0 8.4 7.9 3.9 6.5 4.3 4.5 8.7 3.1 4.7 2.7 4.0 4.5 4.1 3.9 9.8 4.7 3.7 12.3 6.1 3.5 5.0 4.3 5.4 3.1 6.4 3.9 5.6 5.2 11.0 6.3 3.6 3.0 6.1 7.1 3.8 16.7 12.7 12.9 7.1 9.8 10.8 7.5 14.9 15.9 4.5 7.1 4.7 11.7 4.5 8.2 10.1 15.0 12.7 16.9 12.3 11.5 15.3 9.0 5.9 6.7 8.8 7.6 7.8 10.6 11.5 5.5 10.2 11.3 11.8 5.6 7.2 9.8 3.9 6.8 9.9 8.1 9.5 17.4 7.5 13.4 8.1 9.7 3.8 10.1 11.2 7.3 12.8 23.9 20.6 10.1 9.9 4.7 9.6 8.5 14.3 6.8 7.3 6.6 7.4 12.7 11.0 10.7 0.5 2.7 2.3 7.5 2.7 10.6 7.7 7.7 8.6 3.8 9.8 11.3 10.5 0.4 7.6 2.4 6.6 6.6 3.1 3.6 5.0 6.1 5.0 3.4 4.0 4.3 4.5 4.5 4.3 3.9 6.1 3.6 6.4 3.6 6.8 8.4 1.9 2.8 5.9 5.2 8.9 4.0 4.8 8.6 8.6 2.8 0.0 12.5 10.6 7.3 0.4 7.9 3.0 1.4 3.5 5.5 4.1 0.0 5.2 6.6 2.3 7.3 4.5 1.5 2.3 3.8 6.8 3.6 2.9 4.4 10.1 10.0 1.1 2.0 2.4 1.7 0.8 11.1 4.1 1.8 5.6 1.8 12.0 13.4 10.1 17.0 2.0 1.0 8.2 1.9 1.1 1.7 10.2 6.0 11.8 26.3 5.8 8.4 9.6 13.7 4.4 2.0 2.2 6.0 11.8 2.2 1.0 OTC OTCase ENSG00000036473 "Ornithine carbamoyltransferase" P00480 X 38352586-38421446 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Amino-acid biosynthesis, Arginine biosynthesis, Urea cycle" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 124 "intestine: 112.4;liver: 377.8" "Group enriched" "Detected in some" 5 "Hepatic stellate cells: 38.9;Hepatocytes: 99.6;Proximal enterocytes: 82.0;Undifferentiated cells: 25.3" "Cancer enriched" "Detected in some" 20 "liver cancer: 59.1" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA000243, HPA000570" Enhanced Supported Mitochondria NA NA 2200000 "Cluster 85: Liver - Metabolism" "Cluster 2: Hepatocytes - Metabolism" Mitochondria "HPA000243: AB_1079535, HPA000570: AB_1079534" "unprognostic (6.93e-2)" "unprognostic (2.48e-1)" "unprognostic (1.89e-3)" "unprognostic (4.38e-2)" "unprognostic (3.15e-1)" "unprognostic (1.33e-1)" "unprognostic (4.19e-2)" "unprognostic (7.70e-3)" "unprognostic (5.61e-2)" 1.2 0.0 0.2 0.5 0.3 0.0 0.2 0.3 0.4 0.4 0.1 5.0 112.4 0.7 0.0 0.4 0.5 0.4 0.3 0.2 0.3 0.1 377.8 0.9 0.1 0.3 0.3 0.1 1.7 0.0 0.0 0.0 0.4 0.0 2.5 0.1 0.1 0.1 0.0 0.0 87.4 0.5 0.3 0.0 1.9 0.4 0.3 0.0 0.3 0.0 0.0 0.1 0.3 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.3 0.4 0.2 0.3 0.3 0.3 0.4 0.3 0.3 0.4 0.3 0.0 0.0 1.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 2.8 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.1 7.4 0.1 0.0 1.7 1.2 0.0 0.5 0.2 0.0 0.2 0.0 0.0 0.0 0.0 38.9 99.6 0.0 0.0 0.5 8.3 0.0 3.5 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 10.9 0.0 0.0 0.0 82.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 1.0 0.0 0.0 0.0 0.3 0.0 25.3 0.0 OXCT1 "OXCT, SCOT" ENSG00000083720 "3-oxoacid CoA-transferase 1" P55809 5 41730065-41870425 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "heart muscle: 245.9" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 243.7;Distal tubular cells: 187.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HeLa: 238.7;SiHa: 319.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA012047, HPA061425" Enhanced Enhanced Mitochondria "Intracellular and membrane" NA NA 440000 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 20: HeLa - Mitochondria" "Cluster 39: Non-specific - Basic cellular processes" Mitochondria "HPA012047: AB_1854857, HPA061425: AB_2684515" "unprognostic (4.26e-2)" "unprognostic (2.10e-2)" "unprognostic (2.89e-2)" "unprognostic (1.51e-1)" "unprognostic (5.51e-2)" "unprognostic (1.82e-2)" "prognostic unfavorable (1.03e-4)" "unprognostic (7.42e-3)" "unprognostic (1.74e-3)" "unprognostic (1.67e-1)" "unprognostic (2.80e-2)" "unprognostic (3.62e-1)" "prognostic favorable (1.86e-8)" "unprognostic (2.66e-2)" "unprognostic (9.99e-2)" "unprognostic (5.86e-3)" "unprognostic (2.28e-3)" 52.7 15.8 30.4 16.6 34.9 13.3 18.5 23.9 32.7 13.5 15.9 19.2 8.3 14.9 17.6 26.8 12.4 15.2 245.9 36.2 27.1 53.1 1.3 8.0 21.7 19.5 21.4 13.8 5.3 48.6 14.7 5.0 20.0 25.5 21.1 23.6 18.9 29.8 28.5 23.1 12.8 36.6 19.3 11.0 34.2 13.2 25.7 76.8 27.3 42.6 25.9 15.1 13.8 24.5 35.3 1.6 27.9 33.6 84.7 45.0 0.1 62.1 38.9 50.3 30.4 5.7 23.5 91.2 15.0 47.5 25.8 20.5 77.5 55.9 58.5 78.5 9.1 63.9 238.7 11.9 36.8 125.8 20.9 42.7 15.3 49.3 82.2 24.6 46.4 81.6 13.3 114.0 58.1 4.5 105.5 6.1 6.4 0.0 24.5 82.8 78.9 68.7 41.7 2.9 27.9 28.8 319.5 0.3 38.3 2.5 0.4 27.4 28.3 39.7 51.9 68.6 50.6 18.6 16.5 3.6 59.9 90.9 30.9 1.4 1.4 4.7 11.6 1.5 13.8 10.0 11.5 12.7 6.3 7.5 13.6 10.9 0.4 11.3 2.5 2.4 21.5 6.6 30.4 34.9 23.9 32.7 36.2 27.1 19.5 21.4 20.0 19.3 25.7 24.5 8.4 6.4 9.2 37.5 19.2 14.8 11.7 12.4 17.6 14.1 18.8 14.2 243.7 7.2 14.3 11.0 2.1 7.0 18.3 5.0 187.9 5.4 19.1 11.7 18.8 9.8 13.2 23.1 71.5 0.7 11.9 21.3 20.4 31.2 9.5 8.7 6.8 0.3 38.2 13.5 84.2 18.6 12.2 1.3 7.0 8.6 6.2 5.2 16.0 26.2 4.4 11.8 10.3 66.4 46.8 4.8 5.3 7.5 31.3 12.1 2.9 27.4 5.6 21.6 13.1 9.7 24.6 35.6 19.7 27.6 21.6 6.8 26.6 8.6 18.1 9.0 OXCT2 "FKSG25, FLJ00030, SCOT-T" ENSG00000198754 "3-oxoacid CoA-transferase 2" Q9BYC2 1 39769523-39771348 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in many" 11 "testis: 73.0" "Group enriched" "Detected in some" 80 "Early spermatids: 420.5;Late spermatids: 1019.0" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "Karpas-707: 7.6;THP-1: 8.4;U-266/70: 6.2" "Not detected" "Not detected" HPA075423 Enhanced NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 78: Testis - Spermatogenesis" "Cluster 29: U-266 - Adaptive immune response" "Cluster 31: Spermatids - Spermatogenesis" "HPA075423: AB_2732292" "unprognostic (2.42e-3)" "unprognostic (2.11e-1)" "unprognostic (6.50e-2)" "unprognostic (7.16e-2)" "unprognostic (9.68e-2)" "unprognostic (1.13e-1)" "unprognostic (1.32e-1)" "unprognostic (1.93e-3)" "unprognostic (2.74e-1)" "unprognostic (3.16e-1)" "unprognostic (2.57e-3)" "unprognostic (4.18e-2)" "unprognostic (5.39e-5)" "unprognostic (3.24e-1)" "unprognostic (4.59e-1)" "unprognostic (1.70e-1)" "unprognostic (1.85e-1)" 0.3 0.8 1.1 0.4 1.3 0.5 0.3 1.5 2.0 0.5 0.0 1.0 0.7 1.1 0.9 0.7 0.8 0.7 6.6 1.0 0.5 0.4 0.6 0.5 0.6 1.8 1.1 2.3 1.2 0.1 1.1 0.2 1.8 1.3 0.4 0.0 0.3 1.3 0.4 3.2 1.1 0.6 1.3 1.1 0.7 73.0 1.0 3.9 1.8 0.0 0.2 0.4 0.5 4.5 0.4 0.2 0.0 0.9 0.3 1.1 0.0 1.1 0.0 1.0 0.5 3.9 0.4 0.0 0.7 1.6 0.1 0.4 1.2 0.1 0.5 0.0 2.5 0.7 3.0 0.2 1.8 0.0 0.4 0.5 0.3 0.1 0.1 0.0 0.8 0.3 0.2 7.6 0.1 1.1 0.0 1.2 0.1 0.0 1.0 1.1 1.2 1.2 0.3 0.8 1.3 0.6 3.3 0.2 1.1 0.0 0.4 8.4 0.9 0.0 0.2 3.7 0.0 6.2 3.6 0.4 0.0 0.5 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 1.1 1.3 1.5 2.0 1.0 0.5 1.8 1.1 1.8 1.3 1.0 4.5 0.3 0.0 0.6 0.0 2.3 0.3 0.3 0.1 0.0 0.2 0.3 0.5 3.1 0.0 0.0 0.0 0.0 0.0 0.3 1.2 0.0 0.7 420.5 0.2 2.1 0.8 0.0 0.0 0.0 0.7 0.1 1.5 0.0 0.4 0.0 0.3 0.0 0.1 0.2 0.0 0.0 0.8 0.0 0.3 8.3 1019.0 4.1 3.0 1.8 0.0 0.7 0.2 0.0 0.0 0.0 0.4 0.1 6.4 8.9 0.5 0.6 0.0 0.1 0.1 0.0 1.1 2.7 3.4 2.7 0.1 0.4 0.0 0.8 0.6 0.5 0.2 OXSM "CEM1, FASN2D, FLJ20604, KS" ENSG00000151093 "3-oxoacyl-ACP synthase, mitochondrial" Q9NWU1 3 25782917-25794534 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 59.5;Spermatocytes: 48.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021293, HPA021300, HPA021337" Enhanced Approved Mitochondria,Cytosol No No "Cluster 24: B-cells - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" "Mitochondria, Cytosol" "HPA021293: AB_1848772, HPA021300: AB_1848774, HPA021337: AB_1848776" "unprognostic (2.20e-2)" "unprognostic (3.28e-1)" "prognostic favorable (1.35e-4)" "prognostic favorable (5.51e-4)" "unprognostic (1.01e-1)" "unprognostic (8.17e-2)" "unprognostic (2.15e-3)" "unprognostic (1.41e-1)" "unprognostic (1.76e-1)" "unprognostic (2.83e-2)" "unprognostic (3.06e-2)" "unprognostic (1.20e-1)" "prognostic favorable (4.18e-9)" "unprognostic (1.79e-2)" "unprognostic (2.42e-1)" "unprognostic (3.10e-1)" "unprognostic (1.73e-2)" 6.1 11.0 3.1 5.5 3.4 4.0 9.3 3.5 4.6 4.9 5.3 11.1 9.4 4.6 13.9 8.5 6.8 3.9 12.9 3.3 3.6 13.7 22.0 4.9 7.9 3.3 3.3 4.9 10.5 10.0 5.8 5.9 3.4 5.9 12.3 10.2 10.1 5.9 14.6 7.7 7.8 5.2 3.5 7.9 8.2 11.7 3.5 7.1 8.6 15.6 8.8 5.5 5.3 3.4 11.0 18.1 3.8 10.5 10.7 11.6 10.9 8.6 12.4 15.8 11.2 13.8 12.9 20.4 11.5 8.0 9.2 11.3 15.7 16.6 14.9 12.3 16.0 22.5 15.2 16.9 13.1 18.4 13.7 11.0 20.4 12.7 13.3 10.3 13.8 18.9 23.5 16.0 13.7 16.6 13.6 14.4 0.7 8.8 20.6 17.8 9.9 33.7 23.3 6.8 5.4 9.7 13.8 23.6 18.3 6.0 25.5 16.9 8.5 10.0 11.9 13.1 12.7 15.1 18.8 6.6 13.9 16.0 10.4 2.1 5.1 3.7 8.6 6.0 10.1 7.9 8.8 10.8 8.4 8.9 10.2 10.7 0.8 11.4 6.8 8.8 6.0 6.3 3.1 3.4 3.5 4.6 3.3 3.6 3.3 3.3 3.4 3.5 3.5 3.4 5.9 0.0 9.4 3.9 9.3 3.1 5.9 23.0 4.0 6.5 8.7 13.2 13.3 10.0 12.0 11.0 4.2 19.5 7.1 5.4 11.7 13.5 59.5 7.8 7.2 4.9 2.4 2.1 4.5 6.8 16.9 5.9 4.6 6.4 10.1 13.0 7.5 17.4 8.5 5.0 5.1 9.8 14.2 3.8 3.2 15.1 7.2 6.8 5.4 1.0 5.2 9.1 6.2 3.5 3.8 7.5 8.9 4.1 7.8 6.5 10.6 18.4 9.2 7.4 0.0 5.3 5.8 48.0 12.6 7.2 4.4 14.1 5.9 19.2 8.8 3.6 OXSR1 "KIAA1101, OSR1" ENSG00000172939 "Oxidative stress responsive kinase 1" O95747 3 38165089-38255484 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008237, CAB017181" Supported Enhanced Cytosol NA NA 300000 "Cluster 38: Basophils - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 41: Macrophages - Immune response" Cytosol "CAB017181: , HPA008237: AB_1079540" "unprognostic (2.16e-1)" "unprognostic (2.36e-2)" "unprognostic (1.79e-2)" "unprognostic (4.55e-3)" "unprognostic (9.89e-2)" "unprognostic (1.97e-2)" "unprognostic (3.53e-3)" "unprognostic (4.05e-2)" "unprognostic (4.44e-1)" "unprognostic (6.06e-2)" "unprognostic (3.95e-3)" "unprognostic (1.88e-2)" "unprognostic (1.87e-3)" "unprognostic (1.56e-1)" "unprognostic (3.14e-2)" "unprognostic (1.71e-1)" "unprognostic (6.99e-3)" 18.4 17.2 9.7 15.7 10.0 33.8 15.6 13.6 12.5 17.8 13.0 18.3 15.2 14.8 15.6 34.1 12.8 15.1 16.9 9.9 10.8 21.5 18.6 15.5 18.5 11.0 11.0 16.1 12.1 26.3 11.5 16.5 11.1 16.5 19.7 13.0 15.2 16.3 36.7 19.5 15.7 17.6 10.2 15.0 16.8 14.1 11.0 25.1 14.8 35.4 23.4 26.7 21.1 11.2 48.5 21.9 42.5 29.8 29.0 33.3 48.2 41.9 57.1 59.2 63.8 28.3 30.8 53.4 20.8 50.5 25.4 29.4 57.8 43.1 77.5 57.6 24.5 58.6 46.1 31.1 34.6 36.6 34.2 26.6 49.6 54.8 87.8 55.7 37.5 67.7 45.2 29.9 102.7 13.7 71.1 26.4 44.8 31.2 26.1 24.2 35.7 41.4 36.4 36.4 22.0 34.0 45.9 114.2 29.0 46.3 37.7 23.7 34.4 37.0 36.6 56.8 63.0 22.7 29.0 38.7 50.7 44.6 75.3 6.8 1.6 3.9 1.8 2.8 1.9 1.0 2.2 1.7 2.6 1.2 1.7 2.1 3.2 3.1 2.5 1.4 2.8 0.9 9.7 10.0 13.6 12.5 9.9 10.8 11.0 11.0 11.1 10.2 11.0 11.2 19.0 12.8 25.8 46.7 27.3 44.1 35.5 25.3 26.7 13.3 19.4 16.5 32.6 4.3 27.6 27.6 20.9 12.1 27.4 44.0 19.6 28.4 3.9 39.9 32.1 19.0 24.1 29.7 59.6 14.5 21.0 18.4 90.7 91.2 15.8 24.9 14.6 20.5 14.9 21.9 51.9 24.5 10.2 29.8 79.0 2.3 9.6 58.0 7.2 29.0 35.2 8.0 18.6 44.7 42.8 46.5 29.4 12.8 19.5 56.5 27.0 22.5 16.1 7.0 13.1 23.7 22.6 15.1 18.5 41.9 51.9 33.0 29.6 19.6 21.6 115.3 PAFAH2 HSD-PLA2 ENSG00000158006 "Platelet activating factor acetylhydrolase 2" Q99487 1 25959767-25998117 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Lipid degradation, Lipid metabolism" "Hydrolase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "lymphoid tissue: 48.7" "Cell type enhanced" "Detected in all" "Proximal enterocytes: 43.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HMC-1: 52.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA018157 Approved NA Yes "Cluster 2: Granulocytes - Unknown function" "Cluster 29: Non-specific - Vesicular transport" "Cluster 3: HMC-1 - Innate immune response" "Cluster 63: NK-cells & T-cells - Immune response" "HPA018157: AB_1854928" "unprognostic (9.89e-2)" "unprognostic (2.60e-1)" "unprognostic (3.63e-3)" "prognostic favorable (3.28e-6)" "unprognostic (5.19e-2)" "unprognostic (2.12e-1)" "unprognostic (1.05e-1)" "unprognostic (1.78e-1)" "unprognostic (2.43e-1)" "unprognostic (1.04e-1)" "unprognostic (4.46e-2)" "unprognostic (2.62e-1)" "prognostic favorable (0.00e+0)" "unprognostic (8.15e-2)" "unprognostic (8.17e-2)" "unprognostic (1.59e-2)" "unprognostic (7.27e-2)" 4.6 7.3 4.7 6.5 6.5 6.8 9.2 6.3 6.0 8.8 6.7 16.3 17.4 4.9 9.9 7.8 8.3 10.4 9.7 4.5 5.8 19.3 18.3 8.6 8.4 6.4 6.5 4.7 31.2 22.9 5.9 9.2 6.5 8.8 16.6 14.1 10.0 6.3 18.0 11.4 19.0 6.9 5.5 7.6 15.6 7.7 6.5 48.7 16.4 10.7 7.4 7.0 5.5 8.2 8.6 10.7 6.7 7.6 13.9 10.9 13.7 9.6 5.0 8.6 5.7 4.4 18.1 3.8 11.7 5.7 8.1 7.5 10.1 9.3 11.0 7.8 6.1 6.3 4.6 8.8 8.4 3.3 52.5 7.2 21.2 13.2 8.7 4.7 8.3 8.9 8.9 7.1 11.7 3.8 10.3 3.3 13.4 29.9 5.9 8.4 6.3 8.7 13.9 3.0 8.0 6.8 5.7 7.7 18.2 11.0 12.7 6.0 7.8 5.9 7.4 12.5 7.7 13.0 18.1 4.8 12.5 13.2 20.0 36.2 6.7 60.2 23.7 6.4 15.3 3.5 8.3 15.4 5.0 4.4 10.6 14.9 5.8 17.4 2.4 39.0 9.0 8.7 4.7 6.5 6.3 6.0 4.5 5.8 6.4 6.5 6.5 5.5 6.5 8.2 4.6 16.0 12.8 9.8 3.2 1.5 2.1 5.3 1.8 9.5 9.4 4.8 6.8 11.5 11.9 18.4 27.1 11.2 37.7 34.9 3.9 11.1 1.1 8.6 4.5 5.6 7.8 3.2 4.0 7.3 9.5 3.5 12.2 13.2 27.8 7.3 5.7 21.4 11.2 5.0 3.6 18.2 4.1 11.6 1.6 1.0 2.5 7.1 8.8 5.6 7.3 6.3 23.7 4.0 10.0 10.6 15.8 2.6 6.5 4.2 43.1 18.3 8.9 8.8 6.6 5.3 4.1 19.9 8.9 4.5 3.8 10.0 9.0 4.4 19.4 4.9 PAK1 ENSG00000149269 "P21 (RAC1) activated kinase 1" Q13153 11 77322017-77474635 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Apoptosis, Exocytosis" "Allosteric enzyme, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "Excitatory neurons: 219.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Group enriched" "Detected in all" 9 "classical monocyte: 182.2;eosinophil: 292.7;intermediate monocyte: 177.7;myeloid DC: 264.3;neutrophil: 431.8;non-classical monocyte: 202.6" "Group enriched" "Detected in all" 11 "dendritic cells: 264.3;granulocytes: 431.8;monocytes: 202.6" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003565, CAB005312" Enhanced Supported Supported "Plasma membrane,Cytosol" NA NA 560000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 29: U-266 - Adaptive immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane, Cytosol" "CAB005312: AB_2160720, HPA003565: AB_1854935" "unprognostic (1.15e-2)" "unprognostic (3.23e-2)" "prognostic favorable (5.87e-4)" "unprognostic (1.30e-1)" "prognostic unfavorable (1.15e-4)" "unprognostic (6.62e-2)" "unprognostic (8.19e-3)" "unprognostic (4.84e-2)" "unprognostic (1.05e-1)" "unprognostic (1.22e-3)" "unprognostic (1.86e-2)" "unprognostic (2.76e-1)" "unprognostic (1.02e-1)" "unprognostic (6.91e-2)" "unprognostic (1.57e-1)" "unprognostic (4.00e-3)" "unprognostic (1.52e-2)" 12.7 13.4 32.4 33.9 44.5 59.0 18.2 13.9 57.7 21.1 0.0 43.2 43.1 20.9 29.8 21.4 21.9 30.9 9.4 58.3 8.0 26.1 14.5 16.8 20.4 19.2 12.2 21.1 17.5 20.5 20.7 14.7 19.4 19.1 46.5 25.1 19.9 19.7 87.0 16.2 45.7 27.0 0.9 29.3 41.2 25.7 17.1 29.1 40.6 18.8 23.1 27.7 20.7 30.0 39.9 26.7 56.7 25.5 22.8 37.6 45.9 44.6 32.1 42.0 48.7 38.7 52.8 36.3 16.0 39.4 54.4 20.2 40.2 47.8 65.5 41.4 32.6 38.2 17.6 2.3 15.3 64.3 53.5 28.2 28.8 49.2 73.1 36.6 10.1 41.3 25.5 61.2 77.6 2.9 42.3 30.2 84.5 166.2 22.5 62.6 72.3 1.4 10.6 32.9 24.6 23.9 23.6 9.7 19.5 55.0 45.4 29.0 0.9 27.3 47.5 148.9 37.9 165.7 92.4 23.4 23.0 42.5 30.6 2.5 182.2 292.7 11.2 177.7 9.4 16.8 8.4 10.7 264.3 12.9 7.4 14.5 431.8 28.4 202.6 22.9 7.3 92.3 32.4 44.5 13.9 57.7 58.3 8.0 19.2 12.2 19.4 0.9 17.1 30.0 3.1 3.2 20.5 24.2 23.9 11.9 33.3 28.2 23.9 51.6 25.1 19.7 6.2 35.8 30.8 25.8 8.4 25.4 10.2 78.6 45.0 32.4 38.8 37.3 13.5 3.2 37.8 30.5 219.1 56.3 53.5 24.0 45.9 39.7 132.2 35.2 3.6 11.4 49.8 1.7 118.5 50.8 28.5 59.6 152.9 28.3 14.3 80.0 30.2 54.4 121.7 14.9 10.3 53.3 70.7 50.9 57.9 13.2 28.6 28.7 47.9 55.7 39.0 6.4 13.1 13.8 25.2 50.4 53.8 23.6 10.4 95.0 19.3 10.3 52.8 33.2 PAK2 "PAK65, PAKgamma" ENSG00000180370 "P21 (RAC1) activated kinase 2" Q13177 3 196739857-196832647 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins" "Apoptosis, Growth regulation, Host-virus interaction" "Allosteric enzyme, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB007794 Approved Approved Nucleoplasm,Vesicles NA NA 1700000 "Cluster 5: Granulocytes - Unknown function" "Cluster 16: Immune cells - Immune response" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 19: Monocytes & Neutrophils - Innate immune response" "Nucleoplasm, Vesicles" "CAB007794: AB_562363" "unprognostic (1.03e-2)" "unprognostic (6.34e-2)" "unprognostic (2.52e-1)" "unprognostic (2.50e-2)" "unprognostic (1.32e-1)" "unprognostic (1.80e-1)" "unprognostic (5.18e-3)" "unprognostic (1.85e-2)" "unprognostic (7.97e-2)" "unprognostic (1.09e-1)" "prognostic unfavorable (3.36e-4)" "prognostic unfavorable (9.58e-4)" "unprognostic (1.30e-3)" "unprognostic (4.57e-2)" "unprognostic (1.25e-2)" "unprognostic (1.70e-2)" "unprognostic (3.39e-1)" 31.8 18.1 21.2 34.6 24.9 28.1 19.5 25.0 21.7 21.1 19.8 25.6 23.0 21.9 16.0 26.5 20.5 23.8 24.0 19.5 24.6 22.1 33.8 26.3 40.9 26.7 23.4 19.8 18.5 32.6 8.4 33.3 27.7 20.1 26.6 17.4 14.5 18.9 28.3 16.6 22.5 27.0 24.8 43.5 20.9 15.1 23.0 45.1 19.7 25.9 39.4 34.1 16.0 34.1 140.7 49.1 67.6 49.8 47.1 61.9 100.0 69.1 57.0 73.7 66.8 117.5 70.1 89.4 192.7 70.8 75.1 70.2 72.5 66.2 113.6 39.9 35.2 132.2 52.1 92.5 95.0 130.2 122.0 49.6 53.1 66.2 139.2 78.1 74.3 97.3 65.0 107.5 72.9 146.7 124.8 67.2 40.5 74.7 73.4 112.4 38.6 80.9 64.8 96.7 39.6 44.7 92.8 64.7 52.7 51.9 227.0 92.6 76.9 60.9 33.6 64.3 103.1 72.5 138.9 216.4 50.4 127.6 59.1 37.3 20.0 48.0 10.9 23.2 14.7 11.2 12.7 12.6 25.4 11.3 9.1 10.9 47.6 12.2 21.2 9.3 20.7 14.9 21.2 24.9 25.0 21.7 19.5 24.6 26.7 23.4 27.7 24.8 23.0 34.1 164.9 80.1 40.2 37.9 142.8 97.4 89.2 41.8 96.2 42.6 59.7 47.5 59.3 62.9 45.1 82.8 52.1 50.3 135.1 69.6 33.2 71.5 57.1 107.9 112.6 104.0 44.9 72.3 32.2 59.0 101.4 68.9 58.1 96.1 148.8 70.9 66.0 138.6 104.3 55.5 38.9 46.4 57.0 160.5 115.9 75.5 60.9 169.6 33.8 46.9 183.2 63.7 140.1 37.2 61.3 100.4 52.1 45.5 100.0 149.4 58.2 85.2 76.4 45.0 39.5 86.0 75.9 24.5 43.0 103.2 86.2 34.9 139.1 96.3 51.0 124.1 PAK3 "bPAK, hPAK3, MRX30, MRX47" ENSG00000077264 "P21 (RAC1) activated kinase 3" O75914 X 110944285-111227361 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Allosteric enzyme, Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "brain: 31.9;pancreas: 42.7;pituitary gland: 13.7" "Cell type enhanced" "Detected in many" "Bipolar cells: 104.1;Excitatory neurons: 364.0;Inhibitory neurons: 323.5;Oligodendrocyte precursor cells: 165.9;Peritubular cells: 81.3" "Cancer enhanced" "Detected in some" "pancreatic cancer: 1.7" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in single" 5 "MAIT T-cell: 1.0" "Lineage enriched" "Detected in single" 5 "T-cells: 1.0" "Cell line enhanced" "Detected in some" "EFO-21: 10.8;HAP1: 9.9;HDLM-2: 12.4;NTERA-2: 9.7;SCLC-21H: 12.4;SH-SY5Y: 7.7;U-2197: 7.6;U-251 MG: 13.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA044791, HPA060219" Approved Approved Vesicles NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 22: Non-specific - Unknown function" "Cluster 44: HDLM-2 - Immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Vesicles "HPA044791: , HPA060219: AB_2684223" "unprognostic (1.80e-2)" "unprognostic (1.54e-1)" "unprognostic (1.80e-2)" "unprognostic (3.27e-4)" "unprognostic (2.46e-1)" "unprognostic (5.63e-3)" "unprognostic (7.29e-2)" "unprognostic (3.23e-2)" "unprognostic (1.27e-2)" "unprognostic (3.01e-1)" "unprognostic (6.80e-3)" "unprognostic (1.66e-1)" "unprognostic (1.89e-4)" "unprognostic (5.71e-3)" "unprognostic (6.81e-2)" "unprognostic (1.06e-1)" "unprognostic (3.30e-2)" 1.0 5.2 16.9 1.6 16.2 0.1 5.2 0.0 17.6 2.3 0.0 0.7 0.2 5.4 5.8 0.7 2.5 1.6 0.3 17.8 31.9 0.7 0.2 0.9 1.7 1.6 0.0 6.2 42.7 0.1 13.7 0.6 6.0 3.4 0.7 7.0 2.2 4.8 1.6 1.3 0.5 4.7 0.4 2.0 2.0 2.6 13.2 0.6 6.2 0.4 0.8 0.9 0.7 2.8 0.0 0.7 1.4 0.0 0.0 0.0 0.0 0.3 0.4 1.1 0.0 0.0 0.0 0.0 10.8 1.2 1.6 0.0 9.9 0.6 1.3 12.4 0.4 0.0 1.3 0.0 0.0 0.0 0.4 0.3 0.0 0.1 2.2 5.7 0.0 0.2 0.0 0.5 0.0 0.0 0.1 0.2 9.7 0.0 2.2 0.1 4.3 0.0 0.8 0.0 12.4 7.7 0.0 0.4 0.0 6.6 0.0 0.0 0.0 0.7 4.7 7.6 13.6 0.1 0.1 0.1 1.3 0.0 0.1 0.2 0.0 0.0 0.0 0.0 1.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 16.9 16.2 0.0 17.6 17.8 31.9 1.6 0.0 6.0 0.4 13.2 2.8 0.9 3.2 1.1 16.0 0.6 0.3 13.3 0.2 0.0 104.1 6.9 10.4 1.0 20.0 0.7 0.0 0.0 0.3 0.2 0.2 0.0 4.7 4.4 1.0 10.8 2.3 3.6 0.0 364.0 13.1 0.4 10.3 10.2 1.7 1.3 21.9 1.4 0.2 0.2 6.7 323.5 0.3 0.0 0.3 5.7 7.0 34.2 1.1 0.0 17.8 0.7 27.5 1.0 165.9 12.0 5.3 0.0 81.3 1.0 1.7 0.0 0.6 0.0 6.0 0.0 1.6 7.8 1.4 1.4 0.3 1.1 6.7 2.4 29.2 0.3 0.9 PAK4 ENSG00000130669 "P21 (RAC1) activated kinase 4" O96013 19 39125770-39182816 "Enzymes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Apoptosis, Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "A549: 154.7;MCF7: 172.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB025747, CAB044670, HPA070175, HPA072220" Uncertain Supported "Plasma membrane,Cell Junctions" NA Yes "Cluster 26: Non-specific - Mitochondria" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 17: Intestinal endocrine cells - Hormone signaling" "Plasma membrane, Cell Junctions" "CAB025747: , CAB044670: AB_1854940, HPA070175: AB_2686232, HPA072220: AB_2686497" "unprognostic (1.71e-1)" "unprognostic (2.84e-1)" "unprognostic (5.86e-2)" "unprognostic (2.84e-2)" "unprognostic (1.93e-1)" "unprognostic (8.51e-2)" "unprognostic (3.56e-3)" "unprognostic (1.13e-3)" "unprognostic (3.90e-2)" "unprognostic (4.04e-2)" "unprognostic (7.29e-2)" "prognostic unfavorable (9.85e-4)" "prognostic favorable (5.29e-5)" "unprognostic (2.39e-1)" "unprognostic (7.05e-2)" "unprognostic (2.02e-1)" "unprognostic (4.85e-2)" 11.6 20.0 16.7 8.1 18.2 5.3 22.1 14.2 18.4 27.2 14.0 30.2 27.4 20.6 9.4 43.9 23.4 7.5 15.5 13.9 13.4 37.2 26.2 39.6 4.5 17.1 17.2 24.2 31.8 16.2 30.5 16.3 15.8 40.7 8.0 5.8 42.4 11.0 14.0 40.4 25.1 5.7 12.0 13.8 25.3 35.0 15.7 5.4 29.3 4.3 5.4 20.2 30.4 17.0 62.8 154.7 22.7 34.8 7.1 7.5 68.1 29.3 11.7 19.3 19.4 102.1 51.9 14.3 43.3 18.7 25.2 22.7 12.6 23.2 7.2 38.0 35.4 16.9 27.5 50.4 11.3 17.5 23.6 9.0 10.2 18.1 12.9 12.6 25.5 21.4 34.3 11.0 11.8 172.7 18.6 18.9 41.4 55.2 36.7 18.5 17.9 10.9 19.0 67.9 72.2 49.9 29.8 130.6 33.6 11.7 58.1 28.4 42.8 32.6 55.6 37.8 53.0 12.3 12.9 11.9 39.9 10.3 39.9 0.3 0.7 1.2 0.6 0.3 0.8 0.5 0.7 1.1 0.9 0.6 0.5 0.5 0.5 0.9 0.6 0.8 0.9 0.7 16.7 18.2 14.2 18.4 13.9 13.4 17.1 17.2 15.8 12.0 15.7 17.0 5.1 0.0 1.5 9.4 3.9 14.4 15.9 13.8 9.6 18.8 34.2 21.7 2.0 20.0 9.1 18.4 25.0 42.6 4.4 47.5 31.3 20.5 4.1 19.5 8.5 15.0 44.9 5.0 3.9 19.7 67.4 8.8 23.9 23.3 5.7 21.6 10.0 13.3 9.6 21.9 4.2 33.8 28.5 5.3 4.1 6.4 11.8 3.6 7.2 8.4 11.2 13.6 8.2 9.5 13.5 21.8 44.2 10.5 5.8 21.7 39.5 14.4 13.7 13.4 0.0 8.5 7.5 10.4 24.0 20.1 18.8 65.4 6.0 22.3 33.9 24.3 PAK5 "KIAA1264, PAK7" ENSG00000101349 "P21 (RAC1) activated kinase 5" Q9P286 20 9537370-9839076 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "brain: 12.0;retina: 4.7" "Group enriched" "Detected in some" 4 "Breast myoepithelial cells: 6.5;Glandular and luminal cells: 2.0;Granulosa cells: 5.8" "Cancer enhanced" "Detected in single" "glioma: 0.8" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 8 "SCLC-21H: 4.6;SH-SY5Y: 1.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA020444 Approved Approved Nucleoplasm NA NA "Cluster 6: Brain - Smell perception" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 40: Granulosa cells - Unknown function" Nucleoplasm "HPA020444: AB_1854947" "unprognostic (5.14e-5)" "unprognostic (3.35e-1)" "unprognostic (1.05e-1)" "unprognostic (8.63e-2)" "unprognostic (3.21e-1)" "unprognostic (3.04e-1)" "unprognostic (2.25e-4)" "unprognostic (3.76e-1)" "unprognostic (2.56e-2)" "unprognostic (3.83e-1)" "unprognostic (3.35e-2)" "unprognostic (6.04e-2)" "unprognostic (4.58e-1)" 0.0 1.9 3.6 0.0 4.8 0.0 0.4 12.0 8.4 0.1 0.0 0.0 0.0 0.2 0.6 0.2 0.0 1.2 0.0 5.5 0.7 0.2 0.7 0.0 0.0 0.3 1.4 0.0 1.3 0.0 1.2 0.0 0.4 0.4 0.0 4.7 0.3 0.4 0.0 0.4 0.0 0.0 0.2 0.0 0.3 0.2 2.1 0.4 0.0 0.0 0.0 0.0 0.0 4.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.6 1.7 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 4.8 12.0 8.4 5.5 0.7 0.3 1.4 0.4 0.2 2.1 4.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 6.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 2.0 0.0 5.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 PAK6 PAK5 ENSG00000137843 "P21 (RAC1) activated kinase 6" Q9NQU5 15 40217428-40277487 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 25.6;skin 1: 28.2" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 52.7;NK-cells: 16.5;Suprabasal keratinocytes: 19.0" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "CACO-2: 26.5;HaCaT: 32.2;hTCEpi: 19.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA031124 Approved Approved "Nucleoplasm,Nucleoli fibrillar center,Cell Junctions" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 27: Brain & Skin - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 47: Cytotrophoblasts - Unknown function" "Nucleoplasm, Nucleoli fibrillar center" "Cell Junctions" "HPA031124: AB_10601044" "unprognostic (1.85e-3)" "unprognostic (2.15e-1)" "unprognostic (3.33e-3)" "unprognostic (7.79e-3)" "unprognostic (7.08e-3)" "unprognostic (9.57e-2)" "unprognostic (2.71e-1)" "unprognostic (7.73e-2)" "unprognostic (1.34e-2)" "unprognostic (7.13e-3)" "unprognostic (4.04e-2)" "unprognostic (8.87e-3)" "unprognostic (1.72e-1)" "unprognostic (1.79e-1)" "unprognostic (7.37e-3)" "unprognostic (3.34e-2)" 0.2 8.2 11.6 0.4 15.9 0.9 2.1 8.5 16.6 4.5 0.0 1.3 1.5 0.9 1.0 25.6 4.3 1.1 8.3 17.6 3.0 4.7 0.3 2.5 0.9 1.4 1.1 0.6 8.0 8.0 12.1 7.6 1.9 4.4 1.1 0.8 6.1 3.8 4.5 28.2 1.5 0.3 1.8 0.9 3.9 17.7 3.0 0.5 7.5 1.3 1.9 3.5 9.4 5.4 3.9 0.0 0.2 0.0 0.0 0.0 6.0 0.0 0.2 0.7 0.7 26.5 2.9 0.1 3.6 0.0 1.3 32.2 4.5 6.9 0.3 0.2 1.0 0.0 3.0 0.2 0.0 0.1 0.3 0.0 19.4 0.3 4.5 0.2 0.0 5.5 1.8 0.3 0.0 4.5 0.0 0.5 0.5 3.9 2.9 0.2 0.2 2.9 1.5 8.4 7.3 2.0 2.6 10.9 0.3 1.7 1.7 10.3 0.0 0.3 0.6 0.0 0.3 0.1 0.3 0.1 0.7 0.6 0.2 1.2 0.1 1.2 2.3 0.1 0.8 0.6 0.1 1.9 0.3 0.1 0.1 0.4 0.5 0.9 0.1 0.1 0.0 0.6 11.6 15.9 8.5 16.6 17.6 3.0 1.4 1.1 1.9 1.8 3.0 5.4 0.0 0.0 4.2 0.7 0.3 9.8 9.6 4.8 8.6 3.5 2.8 2.9 0.0 4.3 5.4 5.5 0.0 52.7 2.1 0.3 13.7 4.4 8.6 3.3 0.4 0.3 4.9 0.0 8.9 4.3 3.0 0.7 0.5 5.1 0.0 0.7 0.0 0.0 4.1 0.0 7.3 1.1 2.0 0.6 0.9 5.8 1.8 0.3 1.8 1.0 0.0 1.3 16.5 0.5 0.3 2.5 1.0 1.9 0.1 5.2 0.2 0.2 3.9 0.2 0.0 0.3 0.4 1.9 3.3 13.9 19.0 9.0 1.0 0.8 2.0 11.3 PANK1 "MGC24596, PANK, PANK1a, PANK1b" ENSG00000152782 "Pantothenate kinase 1" Q8TE04 10 89579497-89645572 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Coenzyme A biosynthesis" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "kidney: 45.2;liver: 109.7" "Cell type enhanced" "Detected in many" "Distal enterocytes: 37.5;Distal tubular cells: 70.5;Hepatocytes: 149.8;Proximal tubular cells: 53.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 29: Plasmacytoid DCs - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 12: NES - Nervous system development" "Cluster 2: Hepatocytes - Metabolism" "unprognostic (1.00e-1)" "unprognostic (2.19e-1)" "unprognostic (2.02e-2)" "unprognostic (1.09e-2)" "unprognostic (6.71e-2)" "unprognostic (6.97e-2)" "prognostic favorable (1.50e-4)" "unprognostic (1.59e-1)" "unprognostic (1.38e-2)" "unprognostic (1.61e-1)" "unprognostic (4.55e-4)" "unprognostic (4.61e-2)" "prognostic favorable (1.55e-10)" "unprognostic (3.49e-2)" "unprognostic (4.69e-2)" "unprognostic (5.34e-2)" "unprognostic (6.64e-2)" 2.1 4.6 2.8 2.1 3.1 0.5 2.5 7.2 4.2 5.3 9.7 13.9 20.4 1.8 3.8 5.3 3.0 1.7 8.6 3.1 2.7 45.2 109.7 2.2 1.8 3.5 3.4 2.3 1.8 6.5 1.5 2.7 3.8 1.9 17.3 2.0 2.1 2.3 11.4 9.6 17.2 2.3 2.0 1.6 4.6 2.8 4.0 5.2 10.4 28.0 2.6 1.9 3.5 2.8 8.0 5.2 28.1 19.4 14.9 10.8 14.2 4.6 5.0 4.3 5.7 8.2 8.1 5.8 3.0 3.6 3.2 7.9 12.9 2.9 4.6 2.0 5.7 3.9 5.6 16.2 4.4 12.3 2.1 6.6 12.7 6.5 5.1 9.2 5.1 4.9 6.8 0.7 6.3 6.2 13.6 12.5 22.1 21.0 3.1 11.9 5.6 3.8 13.2 3.8 8.7 10.4 5.8 6.9 4.6 16.6 7.5 8.9 2.2 2.6 2.5 5.2 5.7 6.5 12.7 7.2 3.4 9.7 1.8 0.1 0.0 0.0 0.1 0.0 0.2 0.1 0.1 0.2 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.4 0.2 0.1 2.8 3.1 7.2 4.2 3.1 2.7 3.5 3.4 3.8 2.0 4.0 2.8 0.6 6.4 3.7 7.8 1.6 2.3 0.7 2.2 1.8 4.7 2.1 2.0 12.9 10.0 2.5 11.0 2.1 4.7 0.5 37.5 70.5 1.1 0.5 2.5 2.6 1.7 11.4 7.8 21.1 0.7 4.5 1.8 2.0 3.3 0.0 8.4 3.3 149.8 2.4 13.5 32.1 14.8 0.0 3.8 0.7 0.7 1.2 2.2 0.0 7.5 0.4 1.0 0.0 12.1 3.0 0.1 17.9 2.2 1.4 0.5 31.4 53.2 1.5 1.3 0.0 2.2 5.1 0.7 0.8 5.6 2.8 1.8 1.8 1.4 25.1 0.5 PANK2 "C20orf48, FLJ11729, HARP, HSS, NBIA1, PKAN" ENSG00000125779 "Pantothenate kinase 2" Q9BZ23 20 3888839-3929887 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Angiogenesis, Coenzyme A biosynthesis" "Kinase, Transferase" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008440 Approved Supported Cytosol NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 66: Spermatocytes - Spermatogenesis" Cytosol "HPA008440: AB_1079559" "unprognostic (4.50e-2)" "unprognostic (7.96e-3)" "unprognostic (2.26e-1)" "unprognostic (1.39e-2)" "unprognostic (1.68e-1)" "unprognostic (6.00e-2)" "prognostic unfavorable (1.20e-5)" "unprognostic (2.75e-1)" "unprognostic (3.39e-1)" "unprognostic (2.52e-1)" "unprognostic (3.02e-2)" "unprognostic (1.65e-1)" "unprognostic (6.01e-3)" "unprognostic (1.73e-2)" "unprognostic (2.18e-3)" "unprognostic (2.63e-1)" "unprognostic (1.81e-1)" 13.0 12.3 14.5 16.8 13.7 20.9 12.2 15.3 15.9 11.9 14.1 11.4 8.4 11.0 11.3 20.0 16.3 12.1 8.7 15.5 13.5 15.7 18.3 14.1 18.5 12.7 14.1 12.9 10.3 10.9 8.9 15.3 13.3 12.0 14.2 10.3 11.9 10.7 9.6 11.7 11.6 13.7 12.7 14.9 9.1 25.9 13.9 16.8 15.4 11.2 22.0 15.6 9.9 12.4 39.3 29.4 33.7 18.6 39.3 32.6 15.0 25.6 34.2 38.3 48.3 40.8 25.4 34.6 10.6 34.9 70.2 34.9 34.7 57.3 49.3 8.8 9.8 47.4 22.7 80.2 33.3 33.6 15.9 28.7 26.4 39.7 28.7 17.0 36.0 23.3 34.7 30.5 42.5 11.7 30.0 30.3 28.8 22.9 19.5 20.3 46.0 22.4 26.2 45.7 36.2 16.7 30.0 44.3 78.1 32.6 23.6 28.1 24.6 47.7 17.8 60.7 43.3 14.0 50.8 23.3 15.0 30.7 34.2 3.0 10.5 3.4 3.6 11.1 3.5 3.8 3.7 3.4 8.5 4.5 4.1 3.4 5.9 6.8 9.4 3.0 5.9 4.0 14.5 13.7 15.3 15.9 15.5 13.5 12.7 14.1 13.3 12.7 13.9 12.4 23.8 19.2 11.7 23.8 29.2 25.5 17.5 12.0 41.5 22.0 15.8 17.3 9.8 7.2 13.4 14.7 25.0 29.4 38.6 14.4 23.5 19.4 83.1 24.1 20.6 26.7 20.3 42.7 28.6 17.8 36.0 21.1 24.5 24.1 7.6 20.1 26.0 14.0 33.8 35.3 25.3 12.7 10.2 52.8 37.9 17.3 21.1 34.3 19.6 29.0 55.0 14.1 35.0 23.1 17.7 15.9 12.8 22.6 33.2 20.9 15.1 20.6 20.2 21.1 6.6 14.1 23.1 54.6 25.9 37.7 24.3 18.6 31.6 21.2 15.0 20.0 PANK3 FLJ12899 ENSG00000120137 "Pantothenate kinase 3" Q9H999 5 168548495-168579368 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Coenzyme A biosynthesis" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA078669 Approved Approved "Golgi apparatus" NA NA "Cluster 37: B-cells - Transcription" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 53: Intestinal epithelial cells - Unknown function" "Golgi apparatus" "HPA078669: " "unprognostic (1.24e-2)" "unprognostic (5.71e-2)" "prognostic favorable (3.94e-4)" "unprognostic (7.65e-3)" "unprognostic (2.47e-2)" "unprognostic (2.42e-2)" "unprognostic (1.20e-2)" "unprognostic (8.43e-2)" "unprognostic (1.29e-1)" "unprognostic (2.22e-1)" "unprognostic (9.48e-2)" "unprognostic (2.30e-1)" "unprognostic (3.71e-2)" "unprognostic (1.05e-1)" "unprognostic (1.43e-1)" "unprognostic (1.97e-3)" "unprognostic (2.01e-1)" 12.5 20.1 6.8 13.5 8.3 17.9 25.5 20.4 10.0 10.5 2.6 27.0 41.5 13.2 9.3 13.1 7.9 10.0 10.3 8.5 7.9 15.0 43.2 10.3 13.1 8.8 8.7 11.3 10.5 21.8 6.3 14.1 8.5 12.8 25.7 18.0 10.5 7.8 7.7 14.9 30.5 11.7 7.6 12.7 16.1 12.5 9.4 14.2 15.2 12.1 12.5 11.5 11.2 10.4 29.0 16.1 65.2 34.9 23.8 27.5 27.5 17.1 18.0 22.3 32.5 26.9 26.1 44.9 27.3 24.3 35.6 20.3 44.2 34.2 40.1 42.1 21.6 23.4 15.2 20.1 27.7 31.1 29.4 22.1 45.4 28.1 31.4 15.8 26.5 33.1 21.5 43.4 31.0 16.0 31.3 14.1 27.7 22.2 12.1 22.3 44.8 18.2 28.1 42.2 30.2 64.4 19.6 31.5 48.9 32.6 41.2 38.8 27.8 29.9 41.3 17.9 36.8 30.0 45.1 32.5 17.8 31.3 23.8 1.1 1.0 0.5 0.5 1.2 0.7 1.4 0.6 0.6 0.6 0.5 0.4 0.7 0.4 0.3 1.7 0.9 0.7 0.3 6.8 8.3 20.4 10.0 8.5 7.9 8.8 8.7 8.5 7.6 9.4 10.4 26.3 25.6 19.3 6.2 18.3 34.3 23.6 27.4 4.6 28.7 59.1 29.0 16.4 17.2 26.4 25.8 27.1 17.6 29.9 114.8 9.8 17.9 12.8 20.4 28.7 24.8 34.2 36.4 23.3 20.1 14.2 22.0 36.7 32.4 15.2 31.4 14.3 94.2 23.0 28.6 22.6 37.5 26.4 33.6 30.5 17.0 16.8 25.0 23.2 10.3 23.1 12.6 14.4 12.5 17.5 23.0 40.4 17.7 17.0 40.1 98.3 27.2 22.7 26.4 26.3 30.7 28.0 42.1 25.1 26.7 56.1 41.9 18.0 42.4 50.6 52.3 PAPOLA PAP ENSG00000090060 "Poly(A) polymerase alpha" P51003 14 96501433-96567111 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "mRNA processing" "RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 1036.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001788 Supported Supported Nucleoplasm NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 28: BEWO - Transcription regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "HPA001788: AB_1079564" "unprognostic (3.18e-1)" "unprognostic (1.30e-1)" "unprognostic (9.69e-2)" "unprognostic (7.26e-2)" "unprognostic (9.10e-2)" "unprognostic (5.10e-3)" "prognostic unfavorable (2.41e-5)" "unprognostic (2.12e-2)" "unprognostic (2.82e-2)" "unprognostic (1.38e-3)" "unprognostic (3.13e-1)" "unprognostic (1.22e-3)" "unprognostic (3.37e-1)" "unprognostic (1.65e-1)" "unprognostic (1.77e-1)" "unprognostic (1.08e-2)" "unprognostic (4.05e-1)" 52.6 60.5 62.7 66.6 65.1 96.9 62.7 71.7 87.4 61.7 70.1 70.5 57.1 68.5 72.5 59.6 57.9 56.1 61.0 59.9 64.4 60.7 81.6 50.0 77.8 63.0 61.7 76.1 71.6 73.2 53.0 85.3 64.3 54.2 71.8 92.4 63.8 54.0 46.7 57.9 67.6 61.6 62.8 69.3 65.9 75.8 62.1 93.0 68.9 56.4 82.8 66.4 53.5 80.7 126.6 119.4 150.5 152.6 107.2 119.4 331.6 112.9 120.4 132.1 125.8 132.9 125.6 170.9 125.3 134.1 115.2 104.4 50.1 156.9 235.0 141.1 81.1 131.9 88.9 138.5 110.6 166.2 133.4 110.6 134.1 148.0 131.1 127.8 150.5 79.5 128.2 146.5 128.9 184.6 140.5 91.1 102.9 205.0 135.3 146.7 183.5 98.7 132.0 192.7 154.0 102.0 151.4 115.8 111.6 167.9 165.3 158.3 119.0 91.3 72.6 104.1 140.7 114.3 186.7 138.6 144.5 137.5 158.9 73.5 32.0 56.1 23.8 39.3 29.0 38.9 30.2 34.2 38.8 42.7 35.3 33.9 41.3 41.3 37.7 25.1 32.7 36.6 62.7 65.1 71.7 87.4 59.9 64.4 63.0 61.7 64.3 62.8 62.1 80.7 126.3 80.1 122.4 64.6 171.4 229.7 406.3 196.6 126.9 78.2 140.0 101.6 157.2 88.6 160.1 84.6 95.9 346.2 139.6 124.1 183.9 121.4 634.7 326.1 145.4 150.7 117.2 126.8 87.9 137.0 440.7 129.9 95.3 371.7 136.4 113.8 85.6 112.3 155.6 63.9 111.5 154.9 168.9 141.3 239.4 275.3 96.3 153.2 168.9 104.9 171.8 93.4 135.9 105.1 115.2 129.6 118.9 80.5 197.4 373.0 122.5 136.5 253.1 107.2 105.2 131.6 185.0 256.8 203.0 146.0 247.6 1036.0 167.8 131.2 166.1 540.3 PAPOLB PAPT ENSG00000218823 "Poly(A) polymerase beta" Q9NRJ5 7 4857738-4862030 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "mRNA processing" "RNA-binding, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 22 "testis: 29.9" "Cell type enhanced" "Detected in some" "Early spermatids: 94.8;Late spermatids: 89.7;Smooth muscle cells: 18.5;Spermatocytes: 37.4" "Not detected" "Not detected" "Region enriched" "Detected in single" 5 "cerebellum: 1.3" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA047285 Approved Nucleoplasm NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "HPA047285: " "unprognostic (7.58e-2)" "unprognostic (1.25e-1)" "unprognostic (1.68e-2)" "unprognostic (1.78e-1)" 0.0 0.0 0.2 0.0 0.2 0.0 0.0 1.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 29.9 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 1.3 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.0 0.0 0.0 0.0 0.4 1.2 0.2 0.0 0.9 0.2 0.1 1.3 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 94.8 0.2 1.0 0.2 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 89.7 2.5 0.1 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.6 0.0 0.0 0.2 0.8 0.0 0.7 18.5 37.4 4.0 0.0 0.9 0.3 0.1 0.1 0.0 0.3 PAPOLG FLJ12972 ENSG00000115421 "Poly(A) polymerase gamma" Q9BWT3 2 60756253-60802086 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "mRNA processing" "RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017795, HPA035349, HPA035350" Approved Enhanced Nucleoplasm No No "Cluster 38: Basophils - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 24: Non-specific - Transcription regulation" Nucleoplasm "CAB017795: , HPA035349: AB_2674583, HPA035350: AB_2674584" "unprognostic (1.83e-1)" "unprognostic (1.06e-1)" "unprognostic (2.14e-1)" "unprognostic (3.39e-2)" "unprognostic (5.56e-2)" "unprognostic (3.54e-1)" "unprognostic (6.72e-4)" "unprognostic (2.49e-1)" "unprognostic (6.97e-3)" "unprognostic (6.83e-2)" "unprognostic (1.95e-1)" "unprognostic (1.88e-1)" "prognostic unfavorable (4.21e-4)" "unprognostic (2.67e-1)" "unprognostic (1.99e-2)" "unprognostic (3.06e-2)" "unprognostic (2.62e-2)" 3.7 3.0 2.2 2.2 2.3 1.4 3.4 3.2 3.1 4.2 1.7 3.2 1.3 4.1 1.2 3.5 3.2 1.4 3.1 2.3 2.3 2.5 2.3 3.2 3.0 2.5 2.1 4.9 3.5 1.7 3.1 2.0 2.5 2.6 1.5 4.0 3.8 1.2 4.2 3.7 3.6 1.5 1.9 4.1 3.4 3.5 2.6 3.7 6.2 1.7 2.5 3.2 4.1 3.0 1.8 1.5 3.4 2.0 3.1 3.7 2.4 1.5 1.9 1.4 1.2 2.4 1.3 2.6 1.7 1.3 1.4 2.8 3.7 1.8 2.3 4.0 2.1 4.0 1.7 1.7 1.9 4.4 2.4 2.2 2.5 1.7 3.7 2.9 2.6 2.6 3.2 1.9 1.4 1.4 5.0 3.6 5.3 2.9 1.1 3.4 4.9 2.7 1.9 1.4 1.6 2.4 2.2 2.7 1.9 3.2 1.3 2.7 2.4 1.8 1.8 1.3 1.7 2.4 1.5 5.4 2.2 4.8 1.4 3.7 0.8 1.5 1.3 1.0 1.7 1.1 1.2 1.2 0.7 1.4 1.7 1.5 2.2 1.4 1.2 0.8 2.2 0.8 2.2 2.3 3.2 3.1 2.3 2.3 2.5 2.1 2.5 1.9 2.6 3.0 11.5 12.8 12.2 13.1 13.9 12.5 13.5 4.6 12.0 6.8 8.4 8.6 7.9 7.2 8.8 9.2 25.0 6.0 21.0 6.9 3.9 4.8 4.7 6.1 13.2 10.9 2.4 13.3 29.5 4.3 4.6 11.0 6.6 6.6 13.3 14.6 11.7 5.0 7.4 5.0 24.8 5.7 10.2 10.4 22.7 4.3 7.5 17.8 12.4 25.3 12.0 5.1 8.2 19.1 22.1 4.9 6.0 8.6 12.7 15.4 4.3 3.5 7.1 10.3 26.3 9.3 11.3 30.3 17.3 13.2 15.9 8.8 20.8 10.6 4.0 16.2 PAPSS1 "ATPSK1, PAPSS" ENSG00000138801 "3'-phosphoadenosine 5'-phosphosulfate synthase 1" O43252 4 107590276-107720234 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Multifunctional enzyme, Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Glandular and luminal cells: 444.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 6 "basophil: 321.8;eosinophil: 359.8" "Lineage enriched" "Detected in all" 6 "granulocytes: 359.8" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049781 Approved Approved "Nucleoplasm,Nucleoli rim,Mitotic chromosome" Yes No 13000 "Cluster 2: Granulocytes - Unknown function" "Cluster 27: Brain & Skin - Unknown function" "Cluster 2: Karpas-707 - Immune response" "Cluster 44: Endometrium - Transcription" "Nucleoli rim, Mitotic chromosome" Nucleoplasm "HPA049781: AB_2680879" "unprognostic (1.36e-2)" "unprognostic (5.03e-2)" "prognostic favorable (9.14e-4)" "prognostic favorable (8.58e-4)" "unprognostic (1.63e-2)" "unprognostic (1.08e-1)" "prognostic unfavorable (2.70e-5)" "unprognostic (1.58e-2)" "unprognostic (1.05e-1)" "unprognostic (8.92e-2)" "unprognostic (1.42e-1)" "unprognostic (5.76e-2)" "unprognostic (6.23e-3)" "unprognostic (1.29e-1)" "unprognostic (1.72e-1)" "unprognostic (1.61e-2)" "unprognostic (1.38e-1)" 26.3 14.2 36.8 30.8 43.9 26.0 49.9 46.4 50.0 49.6 26.5 20.4 16.0 47.1 43.0 36.2 48.4 26.4 15.9 41.9 40.8 31.7 10.3 44.4 32.9 53.2 41.4 29.2 49.3 26.9 15.8 17.2 51.8 41.1 24.7 22.3 66.0 25.9 6.1 49.7 15.8 33.6 51.1 17.4 62.8 17.0 41.8 35.4 20.3 9.9 51.7 31.7 23.7 66.3 33.6 29.7 49.1 62.1 59.1 74.0 39.6 42.4 77.2 39.4 53.1 45.7 46.7 51.3 26.0 76.1 30.4 40.7 46.8 81.6 50.5 124.2 35.5 60.4 62.6 103.0 32.3 93.0 99.8 61.7 41.2 45.7 37.1 95.2 88.7 63.9 13.6 97.0 111.6 50.7 77.3 28.2 52.6 35.3 33.1 62.4 78.0 15.0 59.6 45.6 55.5 81.4 42.9 63.3 51.9 61.9 37.9 14.1 52.9 49.3 51.0 33.6 35.4 76.9 57.2 48.7 60.1 69.3 79.2 321.8 49.9 359.8 15.6 56.2 18.8 44.8 21.2 18.0 51.4 26.4 13.2 14.9 55.5 27.6 60.8 9.8 39.9 36.7 36.8 43.9 46.4 50.0 41.9 40.8 53.2 41.4 51.8 51.1 41.8 66.3 19.7 96.1 20.2 41.4 25.4 32.0 36.3 73.2 33.6 19.9 48.4 41.5 7.4 50.1 92.3 57.0 10.4 20.6 7.0 10.5 17.6 36.8 6.2 124.2 84.6 25.1 23.4 15.3 112.2 44.7 48.7 35.2 62.2 444.3 42.5 25.0 20.3 10.2 55.1 30.3 64.7 17.5 32.6 46.5 27.8 6.7 18.0 53.5 60.5 29.0 37.4 35.0 10.3 100.0 150.3 33.6 9.1 25.6 86.4 29.1 6.9 28.8 110.0 13.3 26.3 45.2 29.1 19.6 14.7 62.9 40.9 8.9 22.2 19.2 14.8 29.4 PAPSS2 ATPSK2 ENSG00000198682 "3'-phosphoadenosine 5'-phosphosulfate synthase 2" O95340 10 87659613-87747705 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Multifunctional enzyme, Nucleotidyltransferase, Transferase" "Disease variant, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 135.2" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 240.4;Distal enterocytes: 202.4;Hepatocytes: 111.5;Proximal enterocytes: 181.3;Theca cells: 96.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 4 "intermediate monocyte: 4.0;myeloid DC: 2.1;non-classical monocyte: 7.7" "Group enriched" "Detected in many" 7 "dendritic cells: 2.1;monocytes: 7.7" "Cell line enhanced" "Detected in many" "BJ: 189.8;fHDF/TERT166: 473.2;HHSteC: 196.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA071224, HPA075267" Enhanced Approved Mitochondria No No 16000 "Cluster 7: Monocytes - Unknown function" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 41: Macrophages - Immune response" Mitochondria "HPA071224: AB_2686366, HPA075267: " "unprognostic (3.98e-3)" "unprognostic (7.06e-2)" "unprognostic (4.95e-3)" "unprognostic (1.02e-1)" "unprognostic (2.67e-1)" "unprognostic (1.61e-2)" "unprognostic (4.96e-2)" "unprognostic (1.15e-1)" "prognostic unfavorable (1.33e-6)" "unprognostic (3.50e-2)" "prognostic favorable (6.58e-4)" "unprognostic (1.14e-1)" "unprognostic (4.90e-2)" "unprognostic (6.72e-3)" "unprognostic (1.73e-1)" "prognostic unfavorable (3.21e-5)" "unprognostic (3.46e-3)" 33.3 135.2 6.3 26.6 7.0 2.0 20.9 6.2 9.5 17.8 6.2 79.9 29.5 8.5 3.1 10.2 12.4 20.7 11.6 5.8 6.2 23.8 77.0 70.4 11.0 6.9 6.6 27.5 26.1 2.1 3.0 58.5 7.5 6.7 64.3 2.3 16.4 3.4 4.7 3.5 61.8 16.7 6.8 8.5 9.2 11.7 8.0 3.0 21.3 8.7 14.8 16.6 11.5 7.2 19.9 20.0 6.4 0.3 129.4 164.8 0.3 189.8 157.7 110.4 79.9 1.0 4.1 0.1 9.8 473.2 3.5 8.5 13.9 13.3 125.2 0.2 10.0 8.8 13.4 0.1 196.5 0.2 3.8 58.7 0.3 63.7 5.2 135.6 94.2 1.4 0.0 89.4 79.2 74.1 0.1 0.7 7.4 4.8 24.1 0.4 0.1 0.4 117.5 8.7 0.9 1.6 92.5 3.3 1.1 12.6 13.5 5.3 120.0 38.2 22.5 131.5 13.9 0.3 1.0 0.3 18.3 0.2 0.2 0.0 1.1 0.0 0.0 4.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.6 0.0 7.7 0.0 0.0 0.8 6.3 7.0 6.2 9.5 5.8 6.2 6.9 6.6 7.5 6.8 8.0 7.2 49.5 240.4 38.2 3.6 2.6 2.3 0.9 18.0 1.8 0.2 11.5 4.7 4.4 8.6 13.8 9.2 0.0 0.5 0.8 202.4 13.7 6.4 1.2 2.6 18.7 23.2 12.6 5.2 22.2 30.2 0.8 36.1 15.3 11.6 0.0 20.3 36.0 111.5 11.5 0.0 27.6 26.5 4.1 29.8 50.7 0.8 17.4 51.0 1.8 30.0 5.2 1.3 0.0 21.6 1.0 19.4 46.1 5.3 3.1 2.1 181.3 9.8 3.4 0.0 13.1 1.0 20.4 1.2 0.7 1.1 1.3 1.4 1.7 96.4 74.3 1.1 PARP1 "ADPRT, ARTD1, PARP, PPOL" ENSG00000143799 "Poly(ADP-ribose) polymerase 1" P09874 1 226360210-226408154 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Transcription, Transcription regulation" "DNA-binding, Glycosyltransferase, Transferase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 469.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB000147, CAB003839, CAB003840, HPA045168, CAB075726, CAB075727" Supported Supported Enhanced Nucleoplasm,Nucleoli NA NA 150000 "Cluster 43: B-cells - Humoral immune response" "Cluster 16: Immune cells - Immune response" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 47: Cytotrophoblasts - Unknown function" Nucleoplasm Nucleoli "CAB000147: AB_430876, CAB003839: AB_365493, CAB003840: AB_562187, CAB075726: AB_2665732, CAB075727: AB_2665733, HPA045168: AB_2679240" "unprognostic (2.02e-1)" "unprognostic (9.40e-2)" "unprognostic (7.44e-3)" "unprognostic (1.32e-1)" "unprognostic (4.29e-1)" "unprognostic (9.22e-2)" "prognostic unfavorable (3.40e-4)" "unprognostic (2.20e-1)" "unprognostic (3.62e-2)" "unprognostic (1.39e-1)" "unprognostic (2.13e-1)" "unprognostic (1.66e-1)" "prognostic unfavorable (1.35e-5)" "unprognostic (2.38e-2)" "unprognostic (1.82e-1)" "unprognostic (3.14e-2)" "unprognostic (2.64e-1)" 32.0 26.4 33.9 63.9 41.9 29.4 29.5 46.2 33.2 26.2 20.6 43.5 29.3 30.2 19.8 31.3 28.9 20.4 55.1 30.3 36.2 22.4 37.1 27.4 125.5 48.4 39.7 27.5 50.8 94.7 38.0 58.2 47.7 40.7 37.2 44.9 28.9 46.4 94.5 21.1 36.8 45.6 41.9 57.7 29.6 40.5 40.9 64.6 28.4 70.2 150.8 38.7 24.6 58.1 182.4 108.9 295.4 209.3 75.9 61.3 137.1 101.3 119.1 178.2 144.9 175.4 98.1 559.3 147.2 80.9 77.9 135.1 411.6 132.4 144.4 204.1 396.6 216.2 135.9 114.5 44.6 372.2 93.3 61.7 50.5 144.2 101.3 49.3 140.5 132.2 346.9 291.8 94.1 99.6 114.7 110.0 476.2 290.5 165.1 334.2 484.5 533.4 76.4 144.5 264.0 229.2 165.2 190.3 100.1 205.3 159.6 225.8 99.3 93.3 140.9 120.6 235.1 110.9 151.8 472.6 78.2 125.7 214.3 11.1 11.7 12.3 31.2 20.5 45.3 72.2 37.3 36.7 28.2 69.9 28.2 32.5 2.2 22.0 42.3 16.2 49.3 25.7 33.9 41.9 46.2 33.2 30.3 36.2 48.4 39.7 47.7 41.9 40.9 58.1 33.4 54.5 73.6 13.7 169.1 72.3 83.9 56.4 51.2 96.1 58.8 43.3 115.0 44.3 69.8 57.0 141.8 469.2 53.8 27.7 72.4 88.9 34.1 53.3 66.5 62.0 75.0 100.5 16.5 107.0 111.7 49.8 37.8 55.2 122.1 116.2 34.2 69.4 139.6 90.9 17.5 50.0 57.0 47.8 35.7 20.5 40.0 48.3 62.2 16.9 76.9 80.1 95.8 10.1 31.9 48.5 24.2 35.0 186.9 82.8 25.6 48.5 56.4 118.1 46.0 58.7 48.0 88.8 199.6 77.2 48.2 137.6 85.0 103.5 61.9 41.7 PARP2 "ADPRTL2, ARTD2" ENSG00000129484 "Poly(ADP-ribose) polymerase 2" Q9UGN5 14 20343615-20357904 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair" "DNA-binding, Glycosyltransferase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA052003 Approved Supported Nucleoplasm,Nucleoli NA Yes "Cluster 16: MAIT-cells - Unknown function" "Cluster 54: Non-specific - Microtubule organization" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm Nucleoli "HPA052003: AB_2681689" "unprognostic (3.93e-1)" "unprognostic (7.92e-2)" "unprognostic (4.12e-1)" "unprognostic (1.24e-1)" "unprognostic (3.40e-2)" "unprognostic (7.30e-2)" "prognostic unfavorable (6.48e-4)" "unprognostic (1.97e-2)" "unprognostic (4.43e-2)" "unprognostic (9.35e-3)" "unprognostic (1.44e-2)" "unprognostic (1.42e-2)" "unprognostic (3.37e-3)" "unprognostic (2.83e-1)" "unprognostic (9.19e-2)" "unprognostic (1.91e-1)" "unprognostic (2.89e-2)" 17.7 21.1 21.1 10.7 22.0 26.8 17.5 21.4 31.4 18.1 16.4 19.3 12.8 20.9 17.8 14.6 17.5 10.0 17.1 22.5 21.0 15.5 17.2 13.5 14.5 19.5 18.9 22.9 17.9 11.1 21.0 12.9 19.8 13.9 14.0 26.4 14.2 13.4 32.4 19.2 14.2 15.8 19.0 16.5 16.3 23.8 19.8 11.9 16.7 27.1 17.9 13.8 15.3 22.1 55.5 39.5 59.7 45.3 19.4 18.4 43.4 60.2 32.5 74.8 91.8 36.8 51.3 40.4 26.5 19.0 64.8 50.1 78.3 27.5 87.8 32.4 38.3 37.2 46.6 63.3 17.3 77.9 20.4 12.5 23.0 45.5 51.1 20.5 38.5 48.0 39.2 53.4 52.3 33.5 40.1 33.0 33.0 62.8 60.0 49.7 79.7 26.5 30.0 28.2 41.3 28.3 65.3 36.8 17.9 37.4 34.2 25.8 26.6 45.3 68.1 31.5 48.1 49.3 67.7 53.4 19.0 33.3 51.4 1.9 5.0 0.5 8.9 4.8 11.7 6.8 8.4 7.9 5.5 4.1 9.0 8.6 0.1 7.6 2.6 5.6 5.3 4.8 21.1 22.0 21.4 31.4 22.5 21.0 19.5 18.9 19.8 19.0 19.8 22.1 12.1 25.6 6.5 7.2 9.5 6.5 10.5 16.1 18.8 29.2 7.4 10.0 14.0 5.7 19.9 7.3 12.5 25.8 10.2 4.5 7.9 12.8 9.3 9.9 13.3 11.0 4.8 30.3 17.6 8.7 22.2 11.6 7.7 11.3 8.2 18.4 6.8 10.1 11.9 30.3 15.5 5.0 14.2 4.6 5.1 9.8 11.5 6.6 8.8 9.4 4.2 20.7 6.2 6.0 9.3 10.1 4.5 17.0 19.1 4.5 5.3 7.4 28.0 23.2 6.6 9.8 18.5 20.9 41.5 11.3 4.8 14.9 6.2 16.7 7.4 7.0 PASK "KIAA0135, PASKIN, STK37" ENSG00000115687 "PAS domain containing serine/threonine kinase" Q96RG2 2 241106099-241150264 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 19.8;lymphoid tissue: 22.9" "Cell type enhanced" "Detected in many" "Peritubular cells: 24.5;Theca cells: 26.5" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "basal ganglia: 19.8" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" "HPA016450, HPA021079" Uncertain Supported Cytosol NA Yes "Cluster 21: B-cells - Adaptive immune response" "Cluster 3: T-cells - Adaptive immune response" "Cluster 14: REH - Unknown function" "Cluster 63: NK-cells & T-cells - Immune response" Cytosol "HPA016450: AB_1854992, HPA021079: AB_1854993" "unprognostic (1.76e-2)" "unprognostic (1.29e-2)" "unprognostic (2.84e-1)" "unprognostic (1.41e-2)" "unprognostic (1.14e-1)" "unprognostic (8.99e-6)" "unprognostic (1.80e-2)" "unprognostic (1.48e-1)" "unprognostic (1.60e-3)" "unprognostic (1.58e-2)" "unprognostic (1.02e-2)" "unprognostic (6.35e-2)" "unprognostic (7.12e-2)" "unprognostic (1.52e-3)" "unprognostic (1.68e-1)" "unprognostic (6.44e-2)" "unprognostic (4.38e-3)" 1.6 1.1 3.7 7.1 19.8 8.8 2.1 1.0 5.3 2.5 3.1 2.4 3.4 2.1 3.9 3.3 6.1 2.0 1.1 2.7 1.7 3.7 1.4 3.2 13.7 1.9 1.9 1.9 3.6 2.4 4.6 1.0 1.8 10.0 2.3 11.9 2.9 1.4 0.8 4.1 4.5 1.2 0.3 4.1 3.0 16.1 3.2 22.9 5.1 0.2 7.8 2.1 2.2 5.2 7.4 9.9 12.9 16.7 1.1 1.9 17.4 7.0 2.2 6.3 8.8 8.1 7.4 3.8 1.4 1.5 13.8 17.9 15.1 6.1 4.6 15.6 13.8 10.6 19.1 14.4 0.8 14.7 16.0 0.9 4.7 6.5 1.9 2.6 4.6 16.2 14.0 5.2 4.5 8.0 17.5 15.4 14.6 8.8 5.9 27.5 13.3 4.7 2.5 16.0 23.1 7.0 3.9 8.0 3.2 6.8 6.7 10.5 6.1 8.8 7.7 11.1 9.6 6.8 7.4 18.1 5.4 10.9 8.2 4.4 0.6 0.5 1.0 0.4 0.9 4.5 3.9 3.5 0.8 3.9 2.3 2.6 0.8 1.9 0.7 0.4 4.1 2.2 3.7 19.8 1.0 5.3 2.7 1.7 1.9 1.9 1.8 0.3 3.2 5.2 2.3 3.2 7.9 2.6 8.5 2.7 1.2 1.6 2.2 2.6 3.5 4.3 3.1 2.8 1.9 3.7 4.2 0.9 2.2 3.1 0.0 1.5 14.9 13.9 1.6 8.5 0.0 13.3 12.5 2.0 1.7 2.7 3.6 4.4 3.8 11.7 17.5 1.5 2.0 1.7 6.1 3.5 0.0 4.7 2.0 3.5 5.9 2.1 12.4 3.7 2.7 2.1 7.2 0.5 2.6 0.9 1.0 24.5 4.7 1.7 1.9 1.4 12.3 18.7 0.0 2.1 2.1 16.1 12.7 2.6 1.4 0.3 19.1 26.5 3.9 0.9 PBK "CT84, FLJ14385, Nori-3, SPK, TOPK" ENSG00000168078 "PDZ binding kinase" Q96KB5 8 27809624-27838082 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "lymphoid tissue: 22.8;testis: 70.3" "Group enriched" "Detected in many" 5 "Early spermatids: 364.9;Spermatocytes: 436.4" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A-431: 282.8" "Group enriched" "Detected in many" 4 "basal ganglia: 4.7;white matter: 13.9" "Not detected" "Not detected" "HPA005753, HPA050656" Enhanced Supported Approved Cytosol NA Yes "Cluster 48: NK-cells - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" Cytosol "HPA005753: AB_1855018, HPA050656: AB_2681205" "unprognostic (7.17e-2)" "unprognostic (7.21e-3)" "unprognostic (1.04e-3)" "unprognostic (2.77e-2)" "unprognostic (1.50e-1)" "unprognostic (1.27e-1)" "prognostic unfavorable (8.29e-5)" "unprognostic (3.65e-3)" "unprognostic (7.38e-2)" "unprognostic (2.88e-3)" "prognostic unfavorable (6.56e-4)" "unprognostic (1.20e-1)" "prognostic unfavorable (1.18e-12)" "unprognostic (9.61e-2)" "unprognostic (1.86e-1)" "unprognostic (8.30e-2)" "unprognostic (8.68e-2)" 1.1 0.6 0.1 6.6 0.1 9.1 2.3 0.0 0.1 1.1 0.0 8.9 8.4 1.2 0.0 6.6 0.6 0.7 0.2 0.1 0.1 0.4 1.1 0.7 12.8 0.1 0.3 0.2 0.4 0.2 0.0 5.1 0.2 0.4 10.1 0.0 0.9 0.0 0.2 4.8 8.1 2.7 0.1 1.5 3.6 70.3 0.3 22.8 0.5 0.1 12.4 1.6 2.1 0.1 282.8 94.2 94.4 57.9 8.3 15.7 36.9 129.5 63.0 133.2 112.3 33.7 51.2 156.4 43.3 51.7 150.2 76.4 87.6 44.7 145.7 35.8 48.0 35.0 64.6 49.2 0.6 25.7 54.1 4.4 36.0 62.6 32.8 24.3 68.5 75.9 54.3 100.6 160.4 34.5 87.7 29.1 15.6 80.1 80.0 54.4 126.9 41.2 51.2 44.9 36.1 53.2 48.2 56.0 75.0 26.2 58.0 37.3 40.6 85.6 207.3 111.5 141.5 15.4 39.4 70.1 54.0 43.4 188.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.3 0.0 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.3 0.2 0.1 0.3 0.1 0.2 0.0 0.0 0.0 4.2 8.9 2.8 10.8 0.0 0.0 2.9 2.4 0.5 2.8 2.6 0.0 0.0 29.8 1.3 5.5 0.0 0.6 364.9 2.5 2.2 2.4 0.0 61.7 0.1 0.0 49.3 6.7 6.6 3.5 0.0 13.5 5.7 1.7 5.0 0.0 0.1 9.4 6.1 1.9 1.6 76.8 8.4 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.3 3.0 14.0 2.0 1.5 0.3 0.1 0.0 6.6 0.1 5.8 436.4 38.1 9.4 2.4 6.7 1.9 2.4 18.7 3.8 PCIF1 "bA465L10.1, C20orf67, CAPAM, PPP1R121" ENSG00000100982 "Phosphorylated CTD interacting factor 1" Q9H4Z3 20 45934683-45948023 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049517 Enhanced Supported "Nucleoplasm,Microtubules,Cytokinetic bridge" Yes No "Cluster 5: Granulocytes - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 39: CACO-2 - Unknown function" "Cluster 59: Non-specific - Transcription" Nucleoplasm "Microtubules, Cytokinetic bridge" "HPA049517: AB_2680801" "unprognostic (5.42e-3)" "unprognostic (7.76e-2)" "unprognostic (7.69e-2)" "prognostic unfavorable (8.86e-4)" "unprognostic (1.39e-2)" "unprognostic (4.20e-2)" "unprognostic (1.89e-2)" "unprognostic (2.11e-1)" "unprognostic (1.90e-1)" "unprognostic (1.72e-1)" "unprognostic (7.57e-2)" "unprognostic (1.29e-1)" "prognostic favorable (1.50e-6)" "unprognostic (1.01e-1)" "unprognostic (4.44e-2)" "unprognostic (9.14e-3)" "unprognostic (1.24e-1)" 28.7 28.0 20.7 18.6 23.0 33.9 28.7 30.2 24.2 36.1 17.6 30.7 16.5 39.7 10.8 24.4 35.3 16.3 31.9 20.4 20.2 23.4 19.5 28.2 27.3 22.7 21.6 41.7 29.5 22.8 26.0 17.0 22.1 26.2 11.7 15.9 23.6 21.3 41.7 36.7 27.2 21.3 20.9 34.7 25.4 18.1 21.7 34.4 32.0 27.6 19.6 28.6 29.3 24.9 21.2 29.0 22.0 27.2 15.3 18.2 24.2 8.3 25.1 24.9 24.2 49.3 27.7 22.7 27.4 22.6 28.7 23.4 15.8 29.0 10.8 14.1 11.4 29.1 23.1 33.4 28.2 26.4 28.1 25.5 29.9 15.3 24.5 22.3 21.0 37.1 20.8 30.9 17.9 44.6 52.3 48.3 7.8 25.5 24.9 32.2 20.4 28.0 20.1 21.8 30.2 30.0 31.5 29.5 16.1 11.6 31.0 30.7 18.1 30.7 24.1 27.3 16.8 35.4 22.1 21.0 37.7 23.8 18.2 75.5 47.5 80.2 54.5 47.2 43.0 51.6 47.3 50.2 50.3 56.2 48.6 43.0 74.6 74.3 48.0 40.4 54.4 64.0 20.7 23.0 30.2 24.2 20.4 20.2 22.7 21.6 22.1 20.9 21.7 24.9 19.7 3.2 14.2 4.6 33.7 8.7 26.4 7.9 26.2 9.9 17.0 19.7 21.9 20.0 7.1 11.0 2.1 19.5 32.4 14.6 15.6 21.4 9.6 13.3 10.7 16.1 26.5 25.4 2.5 38.6 22.6 15.4 17.3 13.5 14.5 14.9 9.7 12.4 16.9 13.5 3.6 14.0 4.1 16.0 8.7 8.1 11.5 21.5 17.8 1.0 24.9 12.0 33.0 3.0 3.9 28.3 13.1 12.8 35.5 25.4 14.8 23.2 11.0 13.4 0.0 20.2 19.3 14.4 11.9 23.8 10.7 27.8 30.8 15.1 12.0 38.8 PCMT1 ENSG00000120265 "Protein-L-isoaspartate (D-aspartate) O-methyltransferase" P22061 6 149749443-149811420 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 1022.2;Late spermatids: 428.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003239 Approved Supported Cytosol No No 4100000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 47: Non-specific - Unknown function" "Cluster 1: K-562 - Erythropoiesis" "Cluster 29: Early spermatids - Spermatogenesis" Cytosol "HPA003239: AB_1079580" "prognostic unfavorable (4.02e-7)" "prognostic unfavorable (9.58e-4)" "unprognostic (1.35e-2)" "prognostic unfavorable (4.27e-4)" "unprognostic (1.02e-1)" "prognostic unfavorable (1.88e-4)" "prognostic unfavorable (2.58e-4)" "unprognostic (1.91e-2)" "unprognostic (1.58e-2)" "unprognostic (9.02e-2)" "unprognostic (6.45e-2)" "unprognostic (6.77e-2)" "unprognostic (6.14e-2)" "unprognostic (4.38e-1)" "unprognostic (1.70e-1)" "unprognostic (2.17e-2)" "prognostic unfavorable (6.38e-4)" 48.7 43.2 77.5 32.8 85.1 75.9 46.2 70.2 107.1 46.4 56.4 45.5 36.6 38.8 48.5 45.3 39.2 28.4 121.7 87.5 84.8 51.1 73.8 37.9 41.4 80.3 73.0 39.3 38.1 46.3 43.3 42.9 86.2 52.1 43.1 55.8 39.8 50.1 211.9 44.6 34.6 48.9 71.1 34.5 37.8 76.7 72.3 57.4 49.0 163.3 46.7 40.7 38.0 79.2 87.3 68.4 70.4 88.6 152.1 125.9 77.6 140.7 82.9 114.7 143.4 200.1 65.4 117.9 113.0 127.5 126.5 106.6 123.9 143.6 159.9 79.2 180.0 175.5 122.2 192.1 99.2 203.7 197.7 62.8 105.2 128.5 138.5 80.7 107.6 89.8 256.5 107.7 142.3 258.9 98.5 150.4 56.5 84.7 78.6 83.4 89.7 82.6 108.9 62.4 137.5 52.4 111.2 173.9 97.7 82.5 107.8 146.1 83.3 67.2 80.7 124.7 151.2 64.1 109.9 115.4 103.6 135.8 137.7 162.9 193.2 178.0 93.0 182.4 94.7 105.0 93.7 102.8 176.0 81.5 86.5 98.0 101.6 108.5 185.7 79.9 129.2 204.1 77.5 85.1 70.2 107.1 87.5 84.8 80.3 73.0 86.2 71.1 72.3 79.2 57.0 54.5 41.4 21.2 62.6 175.1 74.4 204.4 56.3 72.6 48.0 40.6 154.1 60.1 96.4 79.1 37.5 169.3 66.8 56.6 78.2 113.5 1022.2 51.9 58.4 69.8 55.2 170.1 77.0 110.7 214.0 79.2 26.0 48.8 107.7 38.8 53.9 115.6 119.1 65.6 52.8 72.9 187.2 78.7 127.5 428.1 71.7 78.2 138.7 31.9 143.7 121.2 74.2 30.7 72.2 106.6 57.9 73.7 71.8 67.8 65.1 89.3 106.2 66.3 111.7 64.0 110.4 224.9 96.3 60.7 157.6 148.3 83.0 55.0 58.7 59.1 PCYT1A "CT, CTPCT, PCYT1" ENSG00000161217 "Phosphate cytidylyltransferase 1, choline, alpha" P49585 3 196214222-196287957 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Nucleotidyltransferase, Transferase" "Cone-rod dystrophy, Disease variant, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "EFO-21: 215.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA035428 Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 38: EFO-21 - Unknown function" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm Cytosol "HPA035428: AB_10602045" "unprognostic (8.58e-3)" "unprognostic (2.63e-1)" "unprognostic (8.45e-2)" "unprognostic (8.61e-3)" "unprognostic (2.87e-1)" "unprognostic (1.85e-1)" "prognostic unfavorable (8.65e-5)" "unprognostic (8.52e-2)" "unprognostic (5.99e-2)" "unprognostic (1.65e-2)" "unprognostic (6.72e-3)" "unprognostic (1.74e-2)" "unprognostic (1.10e-1)" "unprognostic (2.11e-1)" "unprognostic (1.47e-2)" "unprognostic (7.16e-3)" "unprognostic (2.41e-2)" 31.4 24.4 15.2 30.0 16.0 45.3 21.0 16.6 15.8 16.7 17.8 25.7 60.3 19.1 13.9 31.0 15.6 20.7 46.4 15.5 21.1 18.3 20.7 22.5 22.9 18.8 18.0 15.8 16.8 22.7 12.9 20.1 18.5 16.6 22.9 14.4 19.3 18.6 73.8 43.0 49.1 23.0 17.5 25.9 24.2 22.4 18.1 18.1 17.2 42.1 26.8 21.0 19.8 17.1 92.6 36.6 25.8 37.2 52.2 53.9 37.0 68.2 47.1 59.2 51.8 92.3 32.8 23.9 215.2 78.1 60.2 71.4 40.5 52.1 50.4 42.1 28.6 68.6 40.6 39.5 45.2 34.3 56.7 47.4 40.0 55.9 39.6 35.4 63.0 21.0 38.3 53.3 58.1 79.6 19.9 17.3 21.4 55.7 53.0 34.5 31.0 37.5 35.7 53.6 25.4 18.3 44.5 79.5 44.2 32.8 114.1 37.2 88.5 45.5 25.2 61.8 92.7 45.8 101.1 44.1 69.6 43.8 56.9 9.6 9.2 10.4 8.8 9.3 7.5 7.2 6.5 9.7 9.1 6.3 4.2 6.3 21.0 9.4 11.0 5.9 14.9 5.2 15.2 16.0 16.6 15.8 15.5 21.1 18.8 18.0 18.5 17.5 18.1 17.1 24.7 16.0 25.7 15.3 19.9 14.5 9.4 19.7 14.2 15.9 14.1 9.4 70.1 20.0 17.5 14.7 25.0 11.9 27.3 36.4 13.7 24.8 76.3 17.8 22.9 23.2 22.1 12.2 20.4 22.9 17.7 17.0 23.4 15.6 20.8 16.1 26.7 35.6 37.4 8.4 22.7 24.2 6.1 34.6 27.1 67.6 19.9 33.9 19.6 20.6 39.4 13.1 39.1 16.1 17.6 24.6 21.1 28.2 27.2 12.0 67.2 23.2 33.9 12.8 26.3 15.0 19.0 46.0 13.2 30.0 21.5 18.6 25.6 25.5 23.8 12.2 PCYT1B "CCT-beta, CTB" ENSG00000102230 "Phosphate cytidylyltransferase 1, choline, beta" Q9Y5K3 X 24558087-24672677 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 13.2;retina: 12.1;testis: 13.4" "Cell type enhanced" "Detected in some" "Astrocytes: 23.5;Early spermatids: 29.1;Late spermatids: 90.1;Muller glia cells: 30.1;Oligodendrocyte precursor cells: 23.6;Oligodendrocytes: 41.9" "Cancer enhanced" "Detected in some" "glioma: 4.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 10.3;CACO-2: 22.2;HEL: 25.7;Hep G2: 10.2;NTERA-2: 11.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006367 Uncertain NA NA "Cluster 17: Basophils - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 36: HEL - Hemostasis" "Cluster 31: Spermatids - Spermatogenesis" "HPA006367: AB_1079585" "unprognostic (4.49e-1)" "unprognostic (2.20e-1)" "unprognostic (1.16e-1)" "unprognostic (7.39e-2)" "unprognostic (9.88e-2)" "unprognostic (6.83e-2)" "unprognostic (5.05e-2)" "unprognostic (2.92e-1)" "unprognostic (1.61e-2)" "unprognostic (1.67e-1)" "unprognostic (1.65e-2)" "unprognostic (5.64e-2)" "unprognostic (2.63e-6)" "unprognostic (2.62e-4)" "unprognostic (4.56e-2)" "unprognostic (1.75e-2)" "unprognostic (1.96e-4)" 0.1 0.8 12.1 0.2 12.2 0.8 0.1 10.6 12.8 0.7 7.5 1.2 0.3 1.6 0.6 0.8 2.2 0.4 2.9 13.2 9.8 0.2 0.0 0.7 0.0 9.5 10.2 1.4 1.5 0.0 1.3 1.3 9.8 0.8 0.2 12.1 0.1 2.4 0.0 0.1 0.6 2.5 8.6 0.2 0.2 13.4 11.4 0.5 0.0 0.0 0.0 0.3 0.3 12.9 0.0 0.0 10.3 0.1 0.0 0.0 0.1 0.0 0.9 0.3 0.1 22.2 0.0 0.0 5.2 0.0 0.0 1.0 4.2 0.0 0.0 0.0 0.1 25.7 0.0 10.2 0.1 0.0 0.3 0.0 0.1 0.3 0.0 0.0 0.0 0.2 0.2 0.0 0.0 0.0 3.9 0.5 11.4 0.0 0.0 0.0 1.4 0.0 0.0 0.0 7.2 5.8 0.0 0.0 0.5 7.1 0.1 0.0 0.0 0.0 0.3 0.0 0.5 0.2 0.0 0.0 4.4 0.7 0.3 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.1 0.1 0.0 0.2 12.1 12.2 10.6 12.8 13.2 9.8 9.5 10.2 9.8 8.6 11.4 12.9 0.0 0.0 0.0 23.5 0.0 0.0 0.2 0.1 0.0 0.4 0.0 0.5 1.6 0.0 0.7 0.0 0.0 0.1 0.0 0.0 0.0 0.8 29.1 10.7 0.2 0.1 1.8 1.3 5.6 0.0 0.0 0.4 0.0 0.2 4.5 5.8 0.0 0.0 0.0 0.0 9.1 0.0 0.0 0.0 0.0 90.1 0.3 0.9 0.0 3.7 0.3 30.1 0.0 23.6 41.9 0.2 0.0 2.6 0.1 0.1 0.0 0.5 6.4 1.6 0.0 0.0 1.0 1.8 0.5 0.0 0.0 0.0 0.0 0.8 0.0 0.1 PCYT2 ET ENSG00000185813 "Phosphate cytidylyltransferase 2, ethanolamine" Q99447 17 81900958-81911432 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Nucleotidyltransferase, Transferase" "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 165.7;testis: 261.7" "Group enriched" "Detected in many" 7 "Early spermatids: 763.2;Late spermatids: 2829.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Hep G2: 218.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA023033, HPA023034" Enhanced Approved Nucleoplasm,Cytosol NA NA 84000 "Cluster 26: Non-specific - Mitochondria" "Cluster 78: Testis - Spermatogenesis" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 25: Spermatids - Spermatogenesis" Cytosol Nucleoplasm "HPA023033: AB_1855094, HPA023034: AB_1855095" "unprognostic (4.05e-3)" "unprognostic (4.39e-3)" "unprognostic (3.81e-1)" "unprognostic (9.72e-2)" "unprognostic (1.92e-1)" "unprognostic (9.86e-2)" "unprognostic (1.24e-2)" "unprognostic (1.06e-1)" "unprognostic (4.24e-1)" "unprognostic (8.97e-3)" "unprognostic (1.84e-1)" "unprognostic (2.34e-1)" "prognostic favorable (4.29e-6)" "unprognostic (1.19e-1)" "unprognostic (8.59e-2)" "unprognostic (1.63e-1)" "unprognostic (4.47e-2)" 29.7 16.8 40.0 9.5 40.1 12.1 25.2 44.4 45.8 14.9 30.4 25.5 63.9 18.0 13.5 26.3 23.9 9.9 47.7 41.2 37.7 44.0 165.7 21.3 12.0 47.0 43.0 20.9 25.3 20.2 14.4 12.0 47.3 24.2 16.7 8.6 22.3 12.1 33.5 16.3 43.0 9.6 41.3 12.8 35.4 261.7 41.0 13.5 16.2 29.3 11.9 21.2 15.1 44.0 42.6 23.9 18.8 53.1 91.8 48.0 27.9 29.9 63.2 40.7 48.0 94.0 43.0 14.8 16.0 31.1 75.3 34.5 28.6 55.1 23.5 4.5 24.3 32.1 33.3 218.2 97.8 32.5 26.0 39.8 31.4 36.8 28.4 14.5 38.6 44.0 60.6 29.6 30.8 35.7 39.3 40.1 15.1 147.2 25.9 25.4 20.2 52.4 49.2 78.8 23.9 21.9 22.4 121.7 29.0 36.5 33.9 75.3 26.1 30.0 19.7 22.9 25.0 19.3 9.1 15.3 31.2 42.8 29.9 1.5 2.4 0.9 4.6 2.6 3.0 4.2 5.5 4.7 4.5 5.6 4.5 4.6 0.7 3.3 2.1 4.4 3.6 3.1 40.0 40.1 44.4 45.8 41.2 37.7 47.0 43.0 47.3 41.3 41.0 44.0 11.5 0.0 17.3 15.0 11.1 5.4 8.1 11.7 6.8 12.5 25.1 11.0 17.0 62.9 9.6 25.8 0.0 73.1 21.0 41.6 119.3 19.5 763.2 29.0 7.5 8.7 13.9 47.8 5.3 18.3 39.7 7.7 36.2 15.8 9.5 39.6 21.8 166.0 24.1 16.8 4.6 29.1 20.3 11.8 3.3 2829.0 27.7 8.1 33.8 0.0 14.7 26.7 22.6 3.5 12.2 17.8 18.8 25.9 13.4 11.4 144.4 130.3 29.4 10.6 26.3 6.2 11.5 253.1 18.1 16.5 5.7 50.8 13.6 34.4 48.7 7.7 PDGFRA "CD140a, GAS9, PDGFR2" ENSG00000134853 "Platelet derived growth factor receptor alpha" P16234 4 54229280-54298245 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" "Chemotaxis, Host-virus interaction" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "ovary: 190.2" "Group enriched" "Detected in many" 8 "Endometrial stromal cells: 423.9;Fibroblasts: 256.4;Leydig cells: 449.8;Oligodendrocyte precursor cells: 499.6;Peritubular cells: 408.9" "Cancer enhanced" "Detected in all" "glioma: 30.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 468.1;ASC TERT1: 216.1;BJ hTERT+: 279.4;fHDF/TERT166: 195.9;HHSteC: 156.3;HSkMC: 392.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004947, CAB018143" Supported Approved "Nucleoplasm,Plasma membrane,Cell Junctions" "Intracellular and membrane" NA NA 300000 "Cluster 34: Basophils - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 36: Stromal cells - Cell proliferation" "Nucleoplasm, Plasma membrane, Cell Junctions" "CAB018143: AB_2162351, HPA004947: AB_2732399" "unprognostic (1.67e-1)" "unprognostic (9.35e-2)" "unprognostic (4.59e-3)" "unprognostic (1.60e-1)" "unprognostic (8.92e-2)" "prognostic favorable (9.33e-4)" "unprognostic (1.24e-1)" "unprognostic (2.00e-2)" "unprognostic (1.46e-1)" "unprognostic (2.18e-2)" "unprognostic (2.18e-1)" "unprognostic (7.01e-2)" "prognostic unfavorable (9.79e-6)" "unprognostic (9.58e-3)" "unprognostic (9.87e-2)" "unprognostic (2.16e-2)" "unprognostic (1.72e-3)" 46.0 28.9 13.9 40.4 13.7 1.6 40.1 8.1 12.8 50.8 18.1 37.7 22.4 44.3 21.8 22.5 50.9 38.5 32.1 11.9 11.0 26.5 16.0 37.9 8.5 16.7 11.9 190.2 13.4 3.0 3.7 62.7 15.1 15.0 35.2 5.3 16.6 18.9 9.6 14.8 31.3 48.1 12.1 46.2 29.4 13.6 8.9 7.6 16.5 41.9 7.2 63.9 38.0 20.0 0.1 0.0 1.0 0.8 468.1 216.1 0.5 25.4 279.4 0.1 0.7 67.6 0.5 0.5 0.5 195.9 0.8 0.6 19.6 0.2 0.1 2.6 1.0 0.7 0.7 1.2 156.3 0.3 0.4 392.0 0.0 31.4 0.0 5.4 0.0 0.7 0.6 0.9 1.1 0.1 0.4 1.2 3.5 0.3 1.1 0.5 0.1 0.1 0.0 0.4 0.6 37.9 0.0 0.5 0.2 2.0 0.7 0.1 0.8 84.9 3.2 93.9 0.2 0.4 0.1 0.8 2.6 0.1 2.2 0.7 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 13.9 13.7 8.1 12.8 11.9 11.0 16.7 11.9 15.1 12.1 8.9 20.0 11.1 0.0 0.5 0.3 0.6 17.1 0.6 2.4 1.2 5.5 4.3 3.2 4.8 0.0 0.8 0.0 0.0 1.4 0.9 0.1 1.9 4.2 2.2 11.7 423.9 5.7 0.0 0.0 1.1 6.7 2.0 256.4 5.1 9.0 0.0 2.6 26.0 1.0 3.1 0.0 19.5 0.2 10.2 0.6 27.3 17.2 449.8 5.4 23.2 39.4 4.7 17.5 0.0 499.6 0.4 20.0 0.0 408.9 0.2 0.9 0.0 0.1 0.5 0.6 0.0 25.7 13.9 1.0 3.4 8.1 15.8 1.4 2.5 49.6 0.0 1.0 PDGFRB "CD140b, JTK12, PDGFR, PDGFR1" ENSG00000113721 "Platelet derived growth factor receptor beta" P09619 5 150113839-150155872 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, RAS pathway related proteins" Chemotaxis "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enriched" "Detected in many" 4 "Sertoli cells: 1288.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "non-classical monocyte: 1.6" "Low lineage specificity" "Detected in single" "Group enriched" "Detected in many" 4 "ASC diff: 1350.1;ASC TERT1: 462.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003842, CAB018144, HPA028499" Enhanced Supported "Golgi apparatus,Vesicles" NA NA 39000000 "Cluster 14: Monocytes - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 48: Smooth muscle cells - ECM organization" Vesicles "Golgi apparatus" "CAB003842: AB_562328, CAB018144: AB_2162497, HPA028499: AB_10602018" "unprognostic (4.75e-2)" "unprognostic (2.48e-1)" "unprognostic (5.21e-2)" "unprognostic (3.60e-2)" "unprognostic (3.27e-1)" "unprognostic (5.61e-2)" "unprognostic (1.02e-1)" "unprognostic (3.36e-2)" "unprognostic (2.12e-2)" "unprognostic (2.57e-3)" "unprognostic (6.72e-2)" "unprognostic (1.25e-1)" "prognostic unfavorable (5.87e-8)" "unprognostic (3.13e-3)" "unprognostic (1.25e-2)" "unprognostic (5.47e-2)" "prognostic unfavorable (8.11e-4)" 171.2 25.1 25.4 27.5 27.2 0.7 106.3 20.5 33.3 155.9 43.5 41.6 11.9 101.1 24.2 24.1 89.6 124.5 75.7 22.1 23.2 49.7 13.4 98.3 27.5 22.1 24.6 105.5 20.8 21.9 23.0 113.3 22.8 56.2 14.1 6.3 34.5 43.3 38.1 65.0 37.9 68.9 19.4 41.4 27.9 18.4 27.7 8.7 66.5 44.1 13.8 58.3 98.6 21.6 0.1 0.3 8.3 0.4 1350.1 462.7 3.0 48.9 202.3 33.5 56.4 5.4 0.0 0.0 6.4 142.0 19.0 0.1 0.1 0.4 15.8 0.0 0.0 0.1 3.3 3.5 190.7 0.0 0.4 210.0 0.0 46.3 0.6 106.6 0.1 0.1 0.1 5.5 5.5 0.0 0.1 0.6 9.0 0.2 0.2 3.7 2.5 0.2 0.0 0.0 0.1 24.8 0.5 0.1 0.0 38.2 0.1 0.6 0.4 53.7 17.2 23.1 2.8 0.4 0.0 0.3 33.4 0.1 1.5 0.0 0.0 0.0 0.9 0.2 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.3 0.0 0.0 1.6 0.0 0.0 0.2 25.4 27.2 20.5 33.3 22.1 23.2 22.1 24.6 22.8 19.4 27.7 21.6 50.8 0.0 1.1 81.9 0.5 24.0 0.5 0.0 2.2 6.6 1.4 3.3 17.3 1.5 0.0 1.8 4.2 0.6 6.0 0.3 0.0 0.8 1.6 2.8 99.5 32.2 0.0 0.0 7.9 0.0 1.1 123.5 2.0 2.3 0.0 2.5 6.4 1.9 1.5 0.0 1.3 0.7 0.0 0.0 35.6 10.9 165.3 3.1 24.9 45.0 0.7 50.7 23.7 10.1 3.3 0.1 0.1 203.8 2.3 0.7 0.3 0.1 0.7 2.9 1288.5 6.6 288.3 1.9 1.6 0.8 15.3 0.8 4.8 4.0 0.4 1.1 PDIK1L CLIK1L ENSG00000175087 "PDLIM1 interacting kinase 1 like" Q8N165 1 26111165-26125555 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA064157 Supported Nucleoplasm NA NA "Cluster 44: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 62: Horizontal cells - Visual perception" Nucleoplasm "HPA064157: " "unprognostic (1.09e-1)" "unprognostic (1.81e-3)" "unprognostic (2.99e-3)" "unprognostic (2.52e-2)" "unprognostic (2.54e-1)" "unprognostic (1.34e-3)" "unprognostic (3.93e-2)" "unprognostic (1.72e-3)" "unprognostic (7.29e-3)" "unprognostic (1.08e-1)" "unprognostic (2.42e-2)" "unprognostic (3.59e-1)" "unprognostic (1.34e-2)" "unprognostic (4.24e-3)" "unprognostic (2.94e-1)" "unprognostic (4.47e-1)" "unprognostic (1.78e-2)" 3.2 3.4 4.4 4.5 4.0 16.6 8.2 6.6 5.1 5.9 2.7 6.9 7.1 4.4 4.6 4.9 5.4 3.9 3.3 4.1 5.2 6.0 8.1 4.6 6.5 3.9 4.0 6.5 7.8 7.0 2.6 3.4 4.8 4.7 7.3 8.3 6.3 5.0 4.8 5.5 5.6 3.6 3.8 4.6 7.3 5.0 4.9 8.6 15.4 5.2 6.3 4.6 3.2 4.9 7.9 2.9 7.5 9.8 2.7 3.8 2.6 2.3 2.7 5.2 3.3 2.0 11.2 17.8 6.3 2.6 4.0 5.6 11.2 4.0 4.4 6.1 7.7 15.3 4.3 2.2 4.7 15.6 9.0 2.2 5.9 4.6 8.5 3.5 4.8 15.3 18.0 16.8 1.8 4.8 23.5 7.4 3.5 9.5 4.7 12.7 7.3 19.2 3.7 6.1 13.3 10.8 8.2 10.0 10.5 2.0 5.4 5.4 4.4 5.5 5.2 7.0 6.9 23.8 26.5 12.0 5.9 19.2 5.0 10.5 3.8 3.3 4.8 3.6 4.5 4.9 6.6 5.3 7.3 4.2 7.0 5.6 0.3 4.4 5.1 2.8 7.9 4.0 4.4 4.0 6.6 5.1 4.1 5.2 3.9 4.0 4.8 3.8 4.9 4.9 6.4 9.6 4.2 5.9 6.2 3.2 1.7 3.5 7.4 18.6 8.6 3.9 2.3 7.2 7.0 1.8 0.0 3.9 2.7 6.5 0.0 3.7 1.3 3.2 5.7 5.0 13.1 6.3 13.7 4.0 0.7 3.8 7.1 4.9 7.0 6.3 5.0 11.1 4.1 23.5 15.4 8.0 4.1 6.3 5.9 0.5 2.5 4.6 3.6 5.6 3.1 11.0 0.0 10.1 12.1 2.9 3.3 3.0 14.0 3.5 4.5 7.5 8.4 11.7 0.0 2.9 3.6 14.0 11.7 14.5 7.4 1.6 5.4 3.0 8.7 3.0 PDK1 ENSG00000152256 "Pyruvate dehydrogenase kinase 1" Q15118 2 172555373-172608669 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Carbohydrate metabolism, Glucose metabolism" "Kinase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 130.4;Plasma cells: 144.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in all" 5 "B-cells: 8.6;granulocytes: 25.2;T-cells: 21.2" "Cell line enhanced" "Detected in all" "U-266/70: 71.8;U-87 MG: 72.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017554, HPA027376" Approved NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 29: U-266 - Adaptive immune response" "Cluster 55: Plasma cells - Humoral immune response" "CAB017554: AB_2161138, HPA027376: AB_1855139" "unprognostic (2.14e-1)" "prognostic unfavorable (7.30e-5)" "unprognostic (1.21e-1)" "unprognostic (3.94e-2)" "unprognostic (6.47e-2)" "unprognostic (1.58e-1)" "unprognostic (1.02e-2)" "unprognostic (1.45e-1)" "unprognostic (9.69e-3)" "unprognostic (6.44e-2)" "unprognostic (5.44e-3)" "unprognostic (1.55e-1)" "prognostic unfavorable (1.10e-8)" "unprognostic (1.82e-1)" "unprognostic (1.94e-1)" "unprognostic (2.56e-2)" "unprognostic (5.34e-2)" 7.7 16.0 2.5 11.6 3.0 15.8 10.1 5.6 5.3 5.5 2.7 16.7 16.5 4.0 3.1 8.5 3.6 6.0 28.1 3.1 2.1 4.8 11.2 4.2 13.1 2.7 6.7 12.2 6.9 4.3 3.8 6.4 3.2 4.7 13.3 27.1 10.2 5.0 9.0 18.1 9.1 4.4 1.3 10.5 13.6 12.2 5.0 8.3 3.9 7.6 19.1 11.0 7.6 2.5 34.0 1.4 8.4 21.0 3.4 5.1 12.1 29.1 23.4 14.3 30.4 8.6 7.1 32.1 15.8 9.1 11.9 14.5 5.8 18.2 45.5 6.6 11.7 39.3 7.1 10.2 6.2 19.6 14.0 6.6 6.4 10.0 16.6 19.8 7.7 16.7 8.5 21.5 19.2 3.5 12.5 24.5 20.8 6.9 9.2 13.1 13.8 52.5 7.4 10.8 15.7 18.0 7.6 8.8 11.1 7.0 5.6 8.0 9.2 22.7 7.4 12.0 7.9 71.8 44.8 26.9 72.6 14.0 4.6 19.6 3.4 25.2 3.7 2.3 4.2 7.3 5.9 4.0 3.5 8.6 21.2 13.5 12.7 2.2 3.2 0.6 12.2 9.2 2.5 3.0 5.6 5.3 3.1 2.1 2.7 6.7 3.2 1.3 5.0 2.5 9.2 3.2 5.0 12.1 33.7 50.1 5.1 15.8 4.6 29.4 7.0 4.7 35.5 2.8 7.0 3.7 47.9 10.2 9.9 11.9 5.9 8.7 130.4 6.4 7.2 9.6 7.8 4.2 35.4 3.7 13.2 8.5 9.7 12.1 5.7 13.3 19.6 20.2 10.2 55.5 32.7 6.6 12.2 12.0 15.2 43.8 3.4 12.9 30.2 30.9 11.4 7.4 10.3 12.1 14.8 9.6 17.5 3.8 144.8 7.2 6.7 1.9 5.0 18.5 6.6 4.6 11.6 9.6 10.4 8.9 43.3 4.1 17.3 5.3 7.0 6.1 PDK2 PDHK2 ENSG00000005882 "Pyruvate dehydrogenase kinase 2" Q15119 17 50094737-50112152 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Carbohydrate metabolism, Glucose metabolism" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 216.2;tongue: 285.0" "Cell type enhanced" "Detected in all" "Proximal enterocytes: 123.0;Proximal tubular cells: 131.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008287 Supported Approved Nucleoplasm,Mitochondria NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 80: Striated muscle - Unknown function" "Cluster 18: U-2197 - ECM organization" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Nucleoplasm, Mitochondria" "HPA008287: AB_1079589" "unprognostic (2.74e-2)" "prognostic favorable (5.87e-4)" "unprognostic (1.16e-1)" "unprognostic (2.43e-3)" "unprognostic (1.22e-1)" "unprognostic (9.63e-3)" "unprognostic (9.80e-3)" "unprognostic (8.39e-3)" "unprognostic (3.19e-2)" "unprognostic (1.25e-1)" "unprognostic (1.17e-2)" "unprognostic (2.21e-1)" "prognostic favorable (9.59e-5)" "unprognostic (3.81e-1)" "unprognostic (2.54e-1)" "unprognostic (5.33e-1)" "unprognostic (1.55e-1)" 40.8 63.8 49.9 8.7 51.2 5.0 26.4 65.7 58.2 30.5 37.1 42.7 28.1 29.4 124.4 21.8 24.3 18.0 116.6 50.6 41.8 62.7 50.8 15.3 10.1 40.8 44.0 48.2 44.3 40.7 17.0 14.7 41.8 23.5 21.5 14.7 25.7 27.4 216.2 26.0 32.5 25.7 40.8 18.4 33.7 13.7 44.6 12.6 27.3 285.0 9.2 30.9 22.2 44.6 12.4 17.5 20.6 18.5 21.2 16.5 2.2 13.2 19.3 19.3 18.5 1.7 13.2 15.5 21.7 37.0 13.0 6.4 13.7 5.3 18.8 30.6 19.3 14.0 17.1 13.2 11.3 0.0 15.0 33.6 19.6 12.5 0.9 33.7 17.2 20.0 5.7 15.0 11.0 15.8 11.8 0.0 4.5 37.2 17.1 17.5 45.8 21.1 10.4 10.4 13.8 20.7 18.7 5.9 9.0 25.0 35.0 13.7 8.8 22.5 18.4 16.0 10.1 29.4 29.9 8.2 33.3 4.9 15.4 14.3 16.2 8.9 16.2 12.9 12.8 12.9 14.8 18.0 18.4 13.8 17.2 18.0 2.6 22.9 14.1 25.8 22.4 17.4 49.9 51.2 65.7 58.2 50.6 41.8 40.8 44.0 41.8 40.8 44.6 44.6 17.9 9.6 10.3 18.3 12.1 15.2 12.3 12.4 17.6 19.0 16.0 26.8 5.4 12.8 11.7 20.2 6.2 19.6 16.7 38.6 58.7 11.7 8.8 6.5 12.1 11.8 13.8 10.8 18.6 9.1 3.6 17.7 13.7 7.8 1.3 19.0 18.2 52.0 19.9 43.7 15.6 50.2 16.2 13.6 9.1 18.9 24.2 12.0 24.9 8.4 14.5 37.3 7.2 6.0 11.3 6.2 55.2 52.6 25.9 6.7 123.0 131.9 6.5 11.0 19.7 15.0 20.5 3.3 11.7 14.6 18.8 7.9 12.9 29.0 36.9 11.3 PDK3 ENSG00000067992 "Pyruvate dehydrogenase kinase 3" Q15120 X 24465270-24550466 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Carbohydrate metabolism, Glucose metabolism" "Kinase, Transferase" "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 71.6;Excitatory neurons: 92.8;Inhibitory neurons: 78.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA046583, HPA072492" Approved Supported Nucleoli,Mitochondria NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 6: T47d - Mammary gland" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Mitochondria Nucleoli "HPA046583: AB_2679707, HPA072492: AB_2686526" "unprognostic (5.41e-3)" "unprognostic (5.43e-3)" "unprognostic (5.35e-3)" "unprognostic (3.40e-1)" "unprognostic (4.05e-3)" "unprognostic (5.38e-2)" "prognostic unfavorable (2.76e-4)" "unprognostic (1.51e-1)" "unprognostic (5.57e-2)" "unprognostic (1.35e-1)" "unprognostic (1.39e-2)" "unprognostic (2.02e-1)" "unprognostic (1.72e-1)" "unprognostic (1.02e-1)" "unprognostic (2.92e-1)" "unprognostic (2.28e-2)" "unprognostic (9.43e-3)" 4.4 2.0 4.4 5.6 6.2 8.9 8.8 1.4 7.5 3.5 2.5 6.1 8.2 2.8 10.9 3.9 5.9 3.2 7.4 13.2 4.7 8.8 4.7 5.0 7.9 2.6 4.2 4.8 2.9 6.7 5.8 4.1 2.4 4.6 5.3 6.0 11.1 2.9 1.4 6.8 8.3 4.5 0.9 7.7 6.9 11.6 9.1 6.3 2.3 1.8 8.0 4.2 4.1 4.2 11.5 5.2 4.2 8.0 0.2 0.0 5.0 3.4 2.4 4.1 6.9 0.5 13.9 10.4 2.3 0.8 11.6 2.1 12.3 8.4 10.4 9.7 6.0 5.3 6.1 3.3 1.4 4.6 5.8 0.9 3.6 1.1 1.2 0.5 6.8 10.9 0.9 16.5 0.5 20.9 9.4 6.0 8.1 12.2 5.6 5.0 8.0 17.3 4.1 21.4 2.6 4.0 17.9 8.0 5.5 7.3 9.6 1.9 0.1 3.3 3.6 5.8 4.2 11.0 8.9 12.9 8.7 7.7 6.4 13.3 15.4 37.9 11.8 19.6 16.5 7.5 9.1 10.3 12.2 7.3 7.6 8.6 57.6 13.3 18.8 3.5 8.3 12.4 4.4 6.2 1.4 7.5 13.2 4.7 2.6 4.2 2.4 0.9 9.1 4.2 3.9 3.2 2.0 19.6 15.2 4.6 9.5 13.5 30.1 3.5 11.1 8.1 6.6 1.5 5.2 1.8 0.0 5.5 16.6 4.2 3.9 4.3 71.6 2.1 2.9 3.8 4.2 14.3 92.8 5.1 32.1 4.9 5.6 2.8 5.7 4.9 5.3 5.3 15.0 8.4 78.0 2.9 10.2 19.8 7.4 35.9 3.7 17.4 16.0 35.6 10.3 3.7 25.7 19.6 14.0 2.1 0.3 5.7 19.0 5.9 13.3 14.2 2.4 3.5 0.0 2.0 10.6 10.2 8.3 6.8 4.4 17.8 18.2 9.7 4.1 8.4 PDK4 ENSG00000004799 "Pyruvate dehydrogenase kinase 4" Q16654 7 95583499-95596516 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Carbohydrate metabolism, Glucose metabolism" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 2300.1;tongue: 1216.5" "Cell type enhanced" "Detected in many" "Adipocytes: 681.3;Cardiomyocytes: 764.5;Kupffer cells: 464.0;Proximal enterocytes: 654.2;Smooth muscle cells: 489.7" "Cancer enhanced" "Detected in all" "renal cancer: 107.8;thyroid cancer: 89.5" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 12 "classical monocyte: 32.5;eosinophil: 38.1;intermediate monocyte: 63.5;myeloid DC: 16.8;non-classical monocyte: 39.8" "Group enriched" "Detected in many" 12 "dendritic cells: 16.8;granulocytes: 38.1;monocytes: 63.5" "Cell line enriched" "Detected in many" 7 "ASC diff: 482.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA056731 Approved NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "HPA056731: AB_2683218" "unprognostic (3.18e-3)" "unprognostic (1.98e-1)" "unprognostic (1.52e-1)" "unprognostic (1.34e-1)" "unprognostic (5.15e-2)" "unprognostic (1.32e-1)" "unprognostic (1.00e-3)" "unprognostic (3.47e-1)" "unprognostic (6.38e-2)" "unprognostic (2.24e-3)" "unprognostic (1.87e-2)" "unprognostic (8.75e-2)" "unprognostic (2.41e-2)" "prognostic unfavorable (1.80e-4)" "unprognostic (9.15e-2)" "unprognostic (4.20e-2)" "unprognostic (1.12e-1)" 451.2 216.3 32.4 33.4 48.0 2.5 388.7 32.9 43.0 76.3 222.0 278.9 72.3 89.0 10.4 151.5 153.5 80.6 480.4 40.0 35.3 127.8 223.4 120.4 24.0 44.5 41.8 240.8 549.3 18.2 39.9 104.8 45.3 91.2 42.6 2.0 60.2 529.5 2300.1 91.9 163.3 62.2 34.8 99.0 173.1 13.3 39.8 13.8 72.1 1216.5 13.5 187.5 95.2 59.4 0.0 37.7 1.5 9.5 482.2 0.8 0.4 0.0 0.0 0.0 0.0 0.0 12.8 0.0 5.3 1.7 1.6 0.0 0.1 0.0 0.0 0.0 1.3 0.2 66.8 0.0 4.5 0.0 0.0 5.3 0.0 0.0 0.0 0.2 2.4 0.0 1.7 0.0 0.2 0.9 0.0 0.4 0.1 0.0 2.1 0.0 0.0 0.3 23.5 2.6 0.5 2.7 0.0 3.0 8.6 2.4 1.3 1.1 0.0 0.0 0.8 2.1 0.1 0.0 0.0 0.1 1.5 0.0 0.0 0.3 32.5 38.1 0.0 63.5 0.1 0.4 0.0 0.0 16.8 1.5 0.0 0.0 2.5 3.3 39.8 0.5 0.0 14.2 32.4 48.0 32.9 43.0 40.0 35.3 44.5 41.8 45.3 34.8 39.8 59.4 681.3 32.1 16.0 154.4 6.0 10.5 279.2 9.2 19.9 0.1 95.9 40.6 764.5 30.0 36.1 378.9 0.0 5.9 3.9 67.7 13.7 7.2 14.9 151.0 52.1 108.0 55.4 9.3 0.4 5.5 0.7 326.9 158.5 347.5 5.1 19.9 199.2 130.5 49.8 0.0 1.2 96.0 6.1 464.0 21.5 6.7 134.2 204.8 90.7 19.7 19.8 8.4 1.0 7.1 26.2 6.2 46.3 44.8 6.4 110.0 654.2 74.2 66.3 0.4 164.3 293.2 489.7 1.8 1.0 12.3 9.2 10.9 5.3 18.7 60.5 157.4 PDPK1 PDK1 ENSG00000140992 "3-phosphoinositide dependent protein kinase 1" O15530 16 2537979-2603188 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" "Activator, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004272, HPA035199" Supported Supported Cytosol NA NA "Cluster 34: Basophils - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 44: HDLM-2 - Immune response" "Cluster 41: Macrophages - Immune response" Cytosol "CAB004272: AB_626657, HPA035199: AB_2674514" "unprognostic (2.67e-2)" "unprognostic (1.63e-1)" "unprognostic (3.12e-3)" "unprognostic (4.21e-2)" "unprognostic (1.34e-1)" "unprognostic (4.69e-3)" "unprognostic (8.37e-2)" "unprognostic (3.18e-2)" "unprognostic (8.17e-2)" "unprognostic (3.70e-2)" "unprognostic (1.52e-2)" "unprognostic (3.28e-2)" "prognostic favorable (1.29e-14)" "unprognostic (2.04e-2)" "unprognostic (5.96e-2)" "unprognostic (1.95e-1)" "unprognostic (2.16e-1)" 11.6 13.5 15.1 12.4 25.2 16.1 11.1 10.2 20.6 10.9 1.5 15.8 17.3 11.8 13.2 13.3 14.7 9.5 15.1 19.2 5.2 17.0 12.4 13.6 15.0 10.8 6.1 14.0 19.4 27.1 11.2 12.1 11.3 13.0 14.9 15.5 17.8 12.2 18.9 14.2 19.6 12.3 3.7 13.9 13.6 14.7 7.7 16.8 15.8 19.2 14.1 11.1 10.4 12.5 13.1 16.5 20.1 13.5 20.3 16.9 21.5 21.7 13.6 18.7 15.6 16.6 15.2 21.4 14.5 20.7 15.9 20.2 24.3 15.3 17.6 39.6 17.1 11.4 23.0 27.7 17.7 19.2 29.0 15.4 27.5 20.1 13.3 17.9 17.3 19.1 22.2 17.0 22.1 27.7 19.2 13.3 12.8 24.3 15.1 39.0 20.2 19.5 18.0 11.5 31.7 16.3 27.9 31.3 11.5 12.8 29.0 23.5 21.6 20.2 20.2 20.0 18.8 22.6 23.4 33.3 9.7 13.1 17.9 5.4 7.1 8.4 4.1 8.3 3.9 4.2 3.8 5.0 5.8 3.4 4.3 4.0 12.5 5.2 8.9 8.0 1.9 4.7 15.1 25.2 10.2 20.6 19.2 5.2 10.8 6.1 11.3 3.7 7.7 12.5 17.6 16.0 19.1 45.1 32.9 26.6 20.8 25.7 26.7 60.2 30.0 22.0 33.8 40.0 23.0 11.0 54.2 47.0 35.2 41.1 13.7 23.1 14.4 35.6 23.8 19.1 21.6 28.0 46.7 23.6 27.9 23.2 23.0 45.3 7.6 18.1 22.5 46.1 26.0 74.0 41.7 29.9 10.2 55.7 51.1 30.4 31.7 37.1 21.4 31.9 43.3 42.3 25.7 37.7 44.2 31.6 24.0 44.4 27.1 30.3 50.2 44.8 41.1 44.9 46.0 30.5 30.0 46.8 36.8 38.5 34.1 104.7 25.7 24.2 31.4 27.1 PDSS1 "COQ1, COQ1A, TPRT, TPT" ENSG00000148459 "Decaprenyl diphosphate synthase subunit 1" Q5T2R2 10 26697701-26746798 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Isoprene biosynthesis, Ubiquinone biosynthesis" Transferase "Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 19.1;lymphoid tissue: 13.8" "Cell type enhanced" "Detected in many" "Inhibitory neurons: 32.5;Proximal enterocytes: 29.8;Undifferentiated cells: 29.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in some" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038032, HPA042741" Uncertain Approved Cytosol NA NA "Cluster 24: B-cells - Unknown function" "Cluster 9: Intestine - Unknown function" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Cytosol "HPA038032: AB_10670650, HPA042741: AB_2678139" "unprognostic (1.41e-2)" "unprognostic (3.92e-1)" "unprognostic (8.92e-3)" "prognostic unfavorable (1.66e-4)" "unprognostic (6.79e-3)" "unprognostic (5.43e-2)" "prognostic unfavorable (1.25e-5)" "unprognostic (2.47e-2)" "unprognostic (9.43e-2)" "unprognostic (2.33e-2)" "unprognostic (2.20e-1)" "unprognostic (4.11e-2)" "unprognostic (2.99e-3)" "unprognostic (2.93e-3)" "unprognostic (8.85e-2)" "unprognostic (9.83e-2)" "unprognostic (6.36e-2)" 2.1 1.4 0.8 5.3 0.9 5.8 2.3 2.6 1.4 1.8 0.6 14.1 19.1 1.9 1.3 4.3 1.5 1.6 2.8 0.8 0.8 6.2 3.6 2.2 4.0 0.8 0.9 1.7 1.3 2.2 0.8 2.4 0.9 1.5 15.1 1.9 1.8 1.3 5.7 1.4 15.3 2.9 0.8 1.8 2.8 2.8 0.9 13.8 1.2 9.5 4.7 3.1 2.2 1.1 15.6 11.8 8.9 16.3 2.9 5.4 12.2 14.0 3.6 20.0 13.7 18.3 8.4 35.0 7.2 7.0 7.6 19.2 28.6 21.8 16.7 14.7 23.6 30.4 9.9 13.6 4.3 20.3 11.6 6.8 9.2 19.0 5.0 3.5 10.7 22.8 28.4 9.3 14.4 24.9 64.6 14.7 17.9 24.9 11.3 29.6 25.1 25.5 12.0 7.3 25.7 15.8 13.5 27.6 15.9 9.2 9.9 23.7 6.8 11.1 17.9 22.9 22.5 3.6 14.1 25.6 10.9 51.3 8.7 0.0 2.8 0.5 0.4 2.3 1.0 0.2 0.8 0.6 2.6 2.4 1.6 0.7 0.1 0.4 1.2 0.7 0.0 0.7 0.8 0.9 2.6 1.4 0.8 0.8 0.8 0.9 0.9 0.8 0.9 1.1 3.6 0.0 0.0 18.9 4.8 6.9 3.6 5.7 8.0 2.9 4.4 5.1 2.2 5.7 3.9 3.7 4.2 7.7 4.9 11.7 7.9 6.1 12.0 2.1 3.8 2.7 10.8 8.4 16.9 3.9 12.4 3.4 10.2 3.3 0.0 3.7 1.8 4.5 8.8 1.7 32.5 13.0 6.1 5.3 2.7 4.1 2.1 7.7 1.8 5.6 6.2 1.2 1.0 6.6 6.5 5.6 9.8 2.6 9.1 3.7 29.8 26.3 2.1 4.9 0.0 4.1 6.5 12.5 9.4 13.6 3.1 6.3 4.8 4.6 29.8 3.3 PDSS2 "bA59I9.3, C6orf210, COQ1B" ENSG00000164494 "Decaprenyl diphosphate synthase subunit 2" Q86YH6 6 107152562-107459564 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Isoprene biosynthesis, Ubiquinone biosynthesis" Transferase "Cancer-related genes, Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Microglial cells: 82.4;Oligodendrocyte precursor cells: 72.9;Oligodendrocytes: 74.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029685, HPA029686" Approved Supported Cytosol NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 1: Thyroid gland - Transcription" "Cluster 32: U-937 - Innate immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol "HPA029685: AB_10600219, HPA029686: AB_10602309" "prognostic unfavorable (1.34e-5)" "unprognostic (1.44e-1)" "prognostic favorable (5.74e-5)" "unprognostic (5.76e-2)" "unprognostic (1.42e-1)" "unprognostic (3.30e-2)" "unprognostic (3.26e-2)" "unprognostic (1.42e-1)" "unprognostic (1.15e-1)" "unprognostic (1.18e-1)" "unprognostic (9.38e-2)" "unprognostic (2.19e-1)" "prognostic favorable (3.75e-7)" "unprognostic (2.25e-1)" "unprognostic (2.86e-1)" "unprognostic (1.29e-1)" "unprognostic (2.11e-2)" 7.9 17.9 4.6 6.3 5.2 9.0 8.1 6.1 5.7 9.2 6.8 12.4 9.3 6.8 6.5 8.6 8.6 8.7 13.9 4.6 5.2 21.6 27.1 8.0 7.6 4.9 4.7 9.1 8.4 13.2 8.5 6.8 5.0 14.6 13.2 6.0 15.3 7.4 12.5 6.3 9.6 8.5 4.7 6.7 9.6 7.7 5.3 8.1 13.3 13.7 7.1 7.6 6.1 6.1 7.6 10.0 8.3 13.2 14.2 18.0 19.2 13.1 16.5 12.4 11.8 10.0 10.8 14.4 11.7 14.7 13.1 10.2 20.3 16.5 16.7 9.1 9.8 14.4 11.4 16.9 15.0 18.5 11.1 13.5 19.1 19.5 15.3 10.8 13.1 16.5 20.7 19.0 12.2 9.3 5.4 19.7 5.3 17.3 12.7 9.7 7.4 11.7 15.2 10.2 8.2 7.1 9.0 15.4 19.7 9.0 12.7 22.3 8.3 8.8 5.2 12.4 11.4 5.3 6.8 11.3 16.3 27.4 16.3 3.2 5.1 2.8 3.7 5.9 5.9 4.7 3.8 4.7 7.0 5.5 5.0 4.8 0.6 3.6 9.9 3.3 5.5 3.4 4.6 5.2 6.1 5.7 4.6 5.2 4.9 4.7 5.0 4.7 5.3 6.1 11.4 16.0 19.1 64.9 12.3 4.2 13.8 11.7 13.6 8.2 9.7 8.3 17.4 12.8 13.9 14.7 2.1 26.9 8.3 15.1 35.2 12.7 37.3 16.3 9.3 8.4 10.3 8.0 53.5 14.5 17.3 9.5 8.2 10.9 14.0 11.9 7.5 32.6 11.8 6.7 67.3 15.3 14.2 9.8 5.1 12.7 5.3 10.2 7.2 82.4 8.5 11.8 6.2 72.9 74.5 13.7 14.4 9.4 13.0 12.2 14.2 40.8 21.0 11.5 26.3 8.7 7.9 21.7 11.5 14.3 5.8 11.9 9.8 13.4 17.0 12.5 PDXK "C21orf124, C21orf97, FLJ21324, FLJ31940, MGC15873, PKH, PNK, PRED79" ENSG00000160209 "Pyridoxal kinase" O00764 21 43719094-43762307 "Disease related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase" "Charcot-Marie-Tooth disease, Disease variant, FDA approved drug targets, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 87.0" "Group enriched" "Detected in all" 4 "Early spermatids: 1717.4;Late spermatids: 4366.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030196, HPA030197, HPA030198, CAB033918" Enhanced Enhanced Nucleoplasm NA NA 830000 "Cluster 24: B-cells - Unknown function" "Cluster 65: Brain - Ion transport" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 31: Spermatids - Spermatogenesis" Nucleoplasm "CAB033918: AB_2162502, HPA030196: AB_10599735, HPA030197: AB_10601792, HPA030198: AB_10603570" "unprognostic (1.01e-1)" "unprognostic (1.99e-1)" "unprognostic (5.88e-2)" "unprognostic (1.87e-1)" "unprognostic (8.29e-2)" "unprognostic (4.31e-3)" "unprognostic (3.64e-3)" "unprognostic (1.32e-1)" "unprognostic (8.66e-2)" "unprognostic (9.34e-2)" "unprognostic (2.10e-1)" "unprognostic (3.54e-1)" "unprognostic (3.70e-2)" "unprognostic (1.31e-3)" "unprognostic (1.10e-1)" "unprognostic (4.78e-2)" "unprognostic (1.51e-3)" 25.6 21.8 79.4 7.6 62.2 12.9 18.4 23.9 87.0 14.3 17.5 17.1 14.1 12.3 10.2 19.7 14.0 7.0 15.5 62.5 51.7 50.4 21.5 20.9 7.0 48.8 59.7 19.1 21.3 17.8 37.3 7.8 54.7 17.2 9.4 10.0 22.7 10.6 6.7 13.9 19.7 6.9 34.4 12.5 16.6 23.9 70.5 10.2 19.1 5.4 9.3 10.9 12.6 57.6 43.4 51.9 8.1 15.5 19.4 27.3 9.9 15.2 23.8 14.5 12.1 42.5 65.7 14.4 15.7 21.9 20.0 31.9 15.8 43.4 9.5 16.2 13.4 14.7 60.9 31.7 38.1 14.0 20.6 38.9 40.7 15.3 16.9 23.6 6.9 6.3 26.2 31.9 13.8 29.1 2.0 24.9 22.3 41.9 19.7 16.7 4.8 40.4 62.9 51.9 7.8 9.3 63.3 57.7 23.2 3.3 19.0 19.4 12.5 10.5 20.3 14.2 14.4 19.3 9.8 8.4 43.2 39.9 10.3 0.6 2.4 0.1 0.8 2.2 1.5 0.6 0.8 0.9 1.3 1.7 0.8 0.6 0.6 0.9 4.3 0.6 0.7 1.4 79.4 62.2 23.9 87.0 62.5 51.7 48.8 59.7 54.7 34.4 70.5 57.6 15.8 80.1 66.6 44.1 37.7 28.4 142.4 72.2 27.3 46.3 74.8 53.5 48.0 34.3 73.2 101.2 22.9 42.9 23.6 97.6 180.0 146.4 1717.4 66.9 28.3 36.1 30.1 15.8 49.3 196.6 86.3 39.4 63.2 73.2 31.8 23.8 17.2 54.2 207.6 52.2 48.7 55.4 12.2 58.2 101.0 4366.5 50.1 118.7 42.7 61.8 38.4 14.9 20.6 16.6 13.5 223.4 36.4 54.2 146.4 184.7 108.4 95.7 71.1 43.3 6.6 17.0 35.0 678.1 30.4 60.7 28.4 124.1 27.3 22.1 57.5 239.8 PDZRN3 "KIAA1095, LNX3, SEMACAP3, SEMCAP3" ENSG00000121440 "PDZ domain containing ring finger 3" Q9UPQ7 3 73382431-73624941 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 256.0;Excitatory neurons: 183.1;Inhibitory neurons: 258.3;Microglial cells: 329.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 19 "plasmacytoid DC: 1.9" "Lineage enriched" "Detected in single" 19 "dendritic cells: 1.9" "Cell line enhanced" "Detected in many" "AF22: 32.1;ASC diff: 57.0;ASC TERT1: 29.6;BJ hTERT+: 42.0;HSkMC: 41.4;U-87 MG: 30.4" "Group enriched" "Detected in many" 4 "amygdala: 15.1;basal ganglia: 8.1;cerebral cortex: 19.5;hippocampal formation: 16.1;white matter: 7.2" "Low region specificity" "Detected in many" "HPA038822, HPA061420" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Cytosol Nucleoplasm "HPA038822: AB_10675952, HPA061420: AB_2684512" "unprognostic (3.22e-2)" "unprognostic (1.32e-1)" "unprognostic (1.00e-2)" "prognostic favorable (3.35e-5)" "unprognostic (1.09e-1)" "unprognostic (5.54e-2)" "unprognostic (8.47e-2)" "unprognostic (3.67e-1)" "unprognostic (1.60e-1)" "unprognostic (7.51e-2)" "prognostic favorable (4.93e-4)" "unprognostic (8.38e-2)" "prognostic favorable (3.65e-7)" "unprognostic (8.63e-3)" "unprognostic (1.63e-1)" "unprognostic (3.72e-2)" "unprognostic (2.86e-3)" 29.9 35.7 14.9 10.2 16.3 0.0 24.0 8.5 20.9 45.2 58.0 84.0 9.2 64.1 24.5 27.8 26.7 27.4 48.0 16.7 10.6 10.7 2.1 14.9 4.5 13.0 11.8 69.4 6.9 0.8 4.6 17.5 11.0 31.7 13.9 6.3 20.9 29.0 91.8 17.3 24.4 38.4 13.1 2.4 38.7 6.4 17.1 2.9 3.6 22.4 1.4 46.7 32.0 13.2 0.0 0.0 32.1 0.1 57.0 29.6 0.1 16.9 42.0 5.0 3.2 16.2 0.0 0.1 0.1 22.8 0.8 0.0 0.0 0.0 4.8 0.0 2.2 0.0 0.0 0.0 9.5 0.0 0.1 41.4 0.0 13.8 0.1 6.0 0.0 0.0 0.0 0.0 4.9 2.1 0.0 0.2 4.6 0.0 0.2 0.0 8.4 0.1 0.0 0.0 3.7 10.5 0.0 7.8 12.7 9.2 4.5 0.0 0.0 20.6 1.5 23.6 2.2 0.7 0.0 0.2 30.4 0.0 16.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 14.9 16.3 8.5 20.9 16.7 10.6 13.0 11.8 11.0 13.1 17.1 13.2 5.9 0.0 0.0 256.0 0.5 2.4 9.7 0.0 1.8 19.3 7.5 7.6 65.0 0.0 0.0 5.5 6.2 0.5 2.7 1.0 1.9 0.0 0.4 2.1 45.2 2.3 21.1 0.0 183.1 0.4 0.5 25.2 2.0 3.3 0.0 35.0 0.0 0.0 0.8 0.0 258.3 9.1 0.0 0.0 2.9 1.3 23.3 0.7 16.0 329.8 0.0 22.5 0.0 21.6 5.5 0.3 0.9 28.2 0.1 10.9 0.1 7.1 0.0 1.9 0.0 4.6 19.6 0.5 6.2 2.9 1.8 0.8 0.5 12.4 3.9 6.3 PELI1 ENSG00000197329 "Pellino E3 ubiquitin protein ligase 1" Q96FA3 2 64092652-64144420 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 5 "bone marrow: 228.5" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 224.1;Plasma cells: 318.8;Squamous epithelial cells: 208.0;Suprabasal keratinocytes: 217.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 76.9" "Group enriched" "Detected in all" 4 "granulocytes: 76.9;monocytes: 23.2" "Cell line enhanced" "Detected in many" "CACO-2: 58.8;U-698: 146.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA053182 Approved Approved "Nucleoplasm,Nucleoli,Intermediate filaments" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 41: Macrophages - Immune response" "Nucleoplasm, Nucleoli, Intermediate filaments" "HPA053182: AB_2682072" "unprognostic (3.33e-2)" "unprognostic (3.43e-2)" "unprognostic (1.79e-2)" "prognostic unfavorable (5.33e-4)" "unprognostic (1.91e-2)" "unprognostic (3.12e-3)" "unprognostic (6.73e-3)" "unprognostic (8.01e-3)" "unprognostic (4.16e-2)" "unprognostic (3.52e-3)" "unprognostic (5.99e-3)" "unprognostic (3.33e-1)" "prognostic unfavorable (5.67e-6)" "unprognostic (6.72e-2)" "unprognostic (6.22e-2)" "unprognostic (8.88e-2)" "unprognostic (1.03e-1)" 27.6 7.9 10.2 28.1 14.4 228.5 25.7 11.9 13.5 17.9 9.2 18.6 17.6 17.3 8.6 42.9 12.7 26.1 11.8 13.8 11.2 10.6 13.5 31.0 24.7 12.2 11.2 5.5 9.3 37.9 15.8 15.6 12.2 8.9 20.1 5.1 18.9 7.7 7.1 29.7 23.2 13.9 12.6 21.8 18.1 10.7 10.9 28.3 9.7 10.0 29.0 22.4 23.7 15.6 3.6 2.8 36.5 24.6 4.2 3.2 8.3 4.8 5.4 4.3 6.8 58.8 4.1 48.3 11.3 1.7 1.6 5.8 11.1 10.5 8.6 12.2 8.9 4.4 1.7 9.5 12.4 4.8 8.3 4.2 8.1 6.4 21.6 4.5 24.3 18.2 2.7 11.7 3.7 0.3 10.6 6.9 23.8 11.1 1.7 13.2 12.6 28.1 17.7 10.8 16.7 23.3 3.6 5.5 12.9 11.3 3.0 3.3 17.5 4.0 5.7 4.0 7.1 27.0 2.8 146.7 2.1 4.3 10.9 15.0 15.6 15.0 0.9 14.1 1.7 8.5 4.8 1.9 5.4 6.6 5.6 2.5 76.9 3.0 23.2 0.5 11.6 6.6 10.2 14.4 11.9 13.5 13.8 11.2 12.2 11.2 12.2 12.6 10.9 15.6 94.5 28.9 49.2 4.6 84.4 224.1 74.6 48.2 105.9 1.7 60.9 50.3 5.7 15.7 52.0 5.5 0.0 1.7 16.9 57.9 1.9 5.3 10.6 34.6 26.4 52.1 25.7 3.4 23.4 26.7 8.6 24.5 75.4 58.7 15.2 6.3 37.5 7.5 22.8 3.3 19.1 23.4 30.5 67.6 103.7 11.2 1.5 107.0 112.1 119.9 30.6 5.5 3.1 82.9 67.9 20.9 45.9 1.9 318.8 44.7 32.7 9.6 43.6 2.0 0.0 10.1 51.9 8.4 9.6 208.0 217.5 4.0 49.4 3.2 32.4 145.8 PELI2 ENSG00000139946 "Pellino E3 ubiquitin protein ligase family member 2" Q9HAT8 14 56117814-56301524 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 114.3;Microglial cells: 100.2;Oligodendrocyte precursor cells: 150.8;Oligodendrocytes: 77.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "neutrophil: 5.6" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HMC-1: 33.3;JURKAT: 43.8;MOLT-4: 39.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA053182 Uncertain Approved "Nucleoplasm,Nucleoli,Intermediate filaments" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 68: Oligodendrocytes - Mixed function" "Nucleoplasm, Nucleoli, Intermediate filaments" "HPA053182: AB_2682072" "unprognostic (3.26e-1)" "unprognostic (2.25e-1)" "unprognostic (9.21e-2)" "unprognostic (8.94e-3)" "unprognostic (1.57e-1)" "unprognostic (1.68e-1)" "unprognostic (2.53e-2)" "unprognostic (3.36e-3)" "unprognostic (1.81e-1)" "unprognostic (2.68e-2)" "unprognostic (1.18e-1)" "unprognostic (2.14e-1)" "prognostic favorable (1.53e-6)" "unprognostic (3.64e-1)" "unprognostic (2.15e-1)" "unprognostic (5.43e-2)" "unprognostic (2.22e-1)" 11.6 3.0 8.1 4.3 7.8 18.6 7.7 27.9 5.9 6.7 5.4 7.0 11.0 6.7 2.5 4.4 6.3 10.0 2.9 5.6 6.6 9.2 2.8 6.7 4.0 8.8 10.9 15.0 28.6 1.9 2.7 3.1 9.3 4.7 3.9 15.1 7.7 3.5 2.4 5.9 9.2 3.3 8.0 6.8 14.4 10.0 10.4 19.1 4.1 3.8 2.0 10.6 5.7 9.2 0.1 3.1 8.8 0.0 4.8 7.2 0.2 1.2 4.2 0.9 0.1 0.2 0.7 0.2 4.2 2.5 0.0 0.9 6.9 0.0 0.4 2.3 2.4 7.9 13.0 0.0 4.1 1.1 33.3 4.5 0.4 0.0 0.0 4.8 1.6 43.8 6.0 0.1 0.9 0.0 39.5 0.4 14.5 0.1 1.2 19.2 0.5 1.8 3.6 15.4 17.5 0.0 0.8 0.1 10.2 5.5 0.0 6.3 0.5 2.6 4.4 0.8 4.4 0.7 0.1 1.0 4.6 5.4 2.6 0.9 1.9 2.4 0.3 1.0 0.5 0.1 0.3 0.2 1.3 0.4 0.2 0.1 5.6 0.3 0.8 0.3 0.0 0.7 8.1 7.8 27.9 5.9 5.6 6.6 8.8 10.9 9.3 8.0 10.4 9.2 13.9 0.0 10.0 114.3 7.7 14.3 10.4 1.7 9.6 30.7 7.1 7.7 2.7 8.6 6.7 12.9 29.2 0.1 11.8 15.0 3.9 5.9 3.7 23.7 14.5 18.0 7.2 5.5 13.5 14.1 0.1 13.5 34.1 21.2 5.7 5.7 17.5 1.0 1.2 21.9 22.1 7.9 2.0 19.7 14.0 5.7 17.1 20.3 17.8 100.2 22.9 9.7 10.3 150.8 77.5 9.1 6.0 18.0 5.6 7.8 12.4 10.1 8.8 19.7 13.1 5.4 22.0 2.0 24.0 4.7 18.3 0.1 6.2 5.6 3.1 12.6 PELI3 MGC35521 ENSG00000174516 "Pellino E3 ubiquitin protein ligase family member 3" Q8N2H9 11 66466327-66477337 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Enteroendocrine cells: 26.5;Horizontal cells: 21.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033750, HPA038875, HPA062281" Uncertain Approved Nucleoplasm,Nucleoli,Vesicles NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 18: U-2197 - ECM organization" "Cluster 62: Horizontal cells - Visual perception" "Nucleoplasm, Vesicles" Nucleoli "CAB033750: AB_2161361, HPA038875: AB_2676249, HPA062281: AB_2684735" "unprognostic (1.15e-1)" "unprognostic (1.58e-1)" "unprognostic (3.04e-1)" "unprognostic (1.43e-1)" "unprognostic (1.02e-2)" "unprognostic (1.89e-2)" "unprognostic (1.30e-2)" "unprognostic (1.94e-1)" "unprognostic (1.35e-1)" "unprognostic (1.19e-1)" "unprognostic (2.19e-3)" "unprognostic (7.91e-3)" "prognostic favorable (8.19e-4)" "unprognostic (1.59e-1)" "unprognostic (1.44e-1)" "unprognostic (1.91e-1)" "unprognostic (3.01e-2)" 7.5 10.2 19.1 2.6 18.7 1.2 7.7 21.1 33.2 12.4 4.4 15.3 3.2 13.9 5.6 6.9 11.2 6.8 8.8 20.5 15.0 6.2 4.2 5.5 3.2 22.7 17.2 13.5 8.2 11.7 13.4 2.4 23.6 14.6 1.7 5.5 8.7 14.8 18.3 7.7 6.3 5.6 13.9 5.1 9.4 7.6 19.5 1.0 6.3 4.6 1.5 14.7 9.1 19.8 20.2 8.1 6.5 5.0 10.2 4.0 5.6 6.2 8.0 5.7 4.9 11.8 4.3 5.0 6.1 6.9 10.3 10.2 4.0 7.8 2.4 9.6 4.1 1.3 7.2 3.5 6.4 1.0 9.2 3.8 8.6 5.8 2.1 8.3 1.2 6.4 2.3 7.2 2.5 11.5 4.2 3.0 3.9 10.2 8.4 13.6 4.7 5.2 3.2 6.3 7.9 4.4 3.2 8.8 21.6 2.8 10.3 5.3 3.4 5.0 7.6 21.7 5.4 6.9 4.2 2.7 10.6 3.1 4.1 0.5 1.0 0.2 1.0 0.8 0.8 1.2 0.8 1.2 1.4 1.5 0.9 0.7 0.0 0.5 3.4 0.4 1.0 0.6 19.1 18.7 21.1 33.2 20.5 15.0 22.7 17.2 23.6 13.9 19.5 19.8 5.0 6.4 2.0 2.0 0.7 1.7 3.8 0.9 4.0 13.3 3.0 4.4 8.1 4.3 0.6 0.0 10.4 2.5 0.4 0.6 1.9 3.2 5.0 0.4 2.6 2.7 26.5 0.0 7.1 2.5 2.1 4.2 2.0 1.1 0.0 2.9 3.3 2.8 3.3 21.9 7.7 1.4 2.0 1.9 1.4 10.4 7.5 2.9 0.0 1.9 2.8 7.5 0.0 2.0 2.5 1.8 1.4 9.8 1.0 2.5 0.9 2.9 0.2 9.7 6.6 3.1 4.9 3.0 3.5 1.8 0.3 0.3 1.3 1.5 0.8 1.5 PEMT "PEMPT, PEMT2" ENSG00000133027 "Phosphatidylethanolamine N-methyltransferase" Q9UBM1 17 17505563-17591708 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "epididymis: 166.2;liver: 267.4" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 122.9;Hepatocytes: 220.1;Peritubular cells: 346.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA042375, HPA073930" Approved Supported "Endoplasmic reticulum,Vesicles,Mitochondria,Cytosol" NA NA "Cluster 24: B-cells - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 36: Stromal cells - Cell proliferation" "Endoplasmic reticulum, Mitochondria" "Vesicles, Cytosol" "HPA042375: AB_10796905, HPA073930: " "unprognostic (1.39e-2)" "unprognostic (3.43e-1)" "unprognostic (2.43e-2)" "prognostic favorable (6.77e-6)" "unprognostic (2.85e-1)" "unprognostic (7.14e-2)" "unprognostic (1.31e-1)" "unprognostic (1.28e-1)" "unprognostic (3.89e-1)" "unprognostic (3.41e-2)" "unprognostic (5.47e-3)" "unprognostic (2.67e-1)" "unprognostic (8.63e-3)" "unprognostic (2.08e-1)" "unprognostic (2.10e-1)" "unprognostic (6.66e-2)" "unprognostic (7.60e-2)" 71.6 33.9 13.2 5.2 13.6 9.2 92.7 16.3 20.0 47.4 12.7 13.6 15.0 36.9 166.2 26.8 26.5 5.4 24.5 13.0 15.2 30.2 267.4 25.8 5.2 14.9 15.3 27.9 32.2 13.3 24.7 7.3 16.8 30.8 3.4 2.8 27.1 24.0 29.5 34.3 13.7 6.8 15.1 12.8 19.5 40.8 14.2 5.6 33.5 10.7 4.5 21.1 24.2 17.2 34.3 64.7 16.5 43.4 34.6 23.8 25.1 21.6 19.0 28.5 22.4 38.2 22.6 29.8 38.1 21.9 21.6 39.9 24.6 12.8 7.2 22.2 86.9 14.8 33.2 55.4 38.4 13.5 21.4 24.9 26.7 19.2 29.1 9.7 15.7 41.3 14.6 12.3 12.9 66.0 23.9 24.2 23.2 65.5 52.4 22.2 26.7 27.5 24.1 12.5 16.7 39.5 15.3 10.1 39.2 31.5 15.6 5.1 13.9 28.1 28.2 47.4 18.9 17.0 12.1 5.5 25.9 18.5 23.6 1.9 41.1 2.1 16.9 39.0 24.8 23.5 22.2 21.5 30.5 28.3 17.2 19.4 3.1 29.3 28.0 27.7 22.4 21.3 13.2 13.6 16.3 20.0 13.0 15.2 14.9 15.3 16.8 15.1 14.2 17.2 38.1 16.0 17.5 4.9 12.4 18.2 21.0 27.9 39.3 4.5 33.0 45.1 15.5 11.5 24.9 27.6 0.0 19.5 5.9 9.3 17.6 33.3 2.9 21.8 122.9 18.5 68.8 17.1 5.4 38.5 21.6 30.4 8.2 23.8 12.7 52.4 10.4 220.1 23.5 5.0 6.8 30.9 24.4 13.7 12.2 14.9 94.8 11.2 21.4 3.7 5.7 34.7 2.1 9.5 4.0 25.7 10.8 346.8 15.3 35.1 21.7 32.3 14.2 6.1 6.6 20.0 23.6 21.0 24.9 39.5 18.2 14.6 12.5 49.3 24.1 23.8 PFKFB1 PFRX ENSG00000158571 "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1" P16118 X 54932961-54998534 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Kinase, Multifunctional enzyme, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "adipose tissue: 28.3;liver: 50.2;skeletal muscle: 111.6;tongue: 40.8" "Cell type enriched" "Detected in some" 5 "Hepatocytes: 15.9" "Cancer enriched" "Detected in some" 11 "liver cancer: 7.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "ASC diff: 8.5;Hep G2: 3.2" "Low region specificity" "Detected in some" "Low region specificity" "Detected in many" NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 15: Hepatocytes - Hemostasis" "unprognostic (2.51e-1)" "unprognostic (2.39e-2)" "unprognostic (1.17e-2)" "unprognostic (4.38e-3)" "unprognostic (1.64e-1)" "unprognostic (6.12e-2)" "unprognostic (1.18e-3)" "unprognostic (1.51e-1)" "unprognostic (2.50e-1)" "unprognostic (3.33e-1)" "unprognostic (3.26e-3)" "unprognostic (2.88e-1)" "unprognostic (5.36e-3)" "unprognostic (5.06e-1)" "unprognostic (4.87e-2)" "unprognostic (1.16e-4)" "unprognostic (1.96e-3)" 28.3 0.5 0.4 0.1 0.5 0.4 9.2 0.3 0.5 0.1 0.1 0.4 0.1 0.1 0.6 1.1 0.1 0.3 0.3 0.4 0.4 1.1 50.2 0.2 0.5 0.5 0.4 0.0 1.2 0.3 0.5 0.2 0.4 0.3 0.5 0.4 0.7 0.2 111.6 0.8 0.5 0.1 0.4 0.3 0.4 0.4 0.4 0.4 1.0 40.8 0.6 0.2 0.2 0.5 0.2 0.1 0.2 0.4 8.5 0.1 0.6 0.0 0.1 0.1 0.0 0.5 0.1 0.4 0.1 0.0 0.4 0.3 0.1 0.2 0.3 0.3 0.7 0.2 0.1 3.2 0.0 0.0 0.3 0.1 0.4 0.0 0.2 0.0 0.0 0.8 0.1 1.4 0.1 0.5 0.4 0.2 0.2 0.2 0.2 0.3 0.1 0.1 0.0 0.2 0.2 0.1 0.3 1.0 0.1 0.7 0.2 0.0 0.1 0.1 0.3 0.2 0.1 0.7 1.2 0.2 0.1 0.2 0.1 0.0 0.0 0.0 0.0 0.1 0.3 0.2 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.4 0.5 0.3 0.5 0.4 0.4 0.5 0.4 0.4 0.4 0.4 0.5 0.1 0.0 0.0 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.7 15.9 0.1 0.0 1.5 0.1 0.0 0.9 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 3.1 0.1 0.1 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.5 0.3 0.4 0.0 0.0 0.1 0.1 0.0 0.0 0.0 PFKFB2 ENSG00000123836 "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2" O60825 1 207034366-207081024 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Kinase, Multifunctional enzyme, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "retina: 83.3" "Cell type enhanced" "Detected in many" "Astrocytes: 105.1;Cardiomyocytes: 79.0;Late spermatids: 158.2;Rod photoreceptor cells: 110.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 6 "eosinophil: 20.8;plasmacytoid DC: 23.8" "Group enriched" "Detected in many" 8 "dendritic cells: 23.8;granulocytes: 20.8" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA049975, HPA063575" Uncertain Enhanced Nucleoplasm NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 54: Non-specific - Microtubule organization" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 65: Plasmacytoid DCs - Unknown function" Nucleoplasm "HPA049975: AB_2680977, HPA063575: AB_2685046" "unprognostic (1.30e-1)" "unprognostic (6.66e-2)" "unprognostic (1.48e-1)" "unprognostic (1.75e-2)" "unprognostic (2.27e-1)" "unprognostic (3.76e-2)" "unprognostic (9.96e-3)" "unprognostic (9.74e-2)" "unprognostic (7.27e-2)" "unprognostic (2.27e-2)" "unprognostic (6.01e-2)" "unprognostic (1.30e-1)" "prognostic favorable (3.23e-7)" "unprognostic (1.54e-2)" "unprognostic (1.27e-1)" "prognostic unfavorable (8.63e-4)" "unprognostic (1.86e-2)" 4.3 6.8 13.2 8.3 14.5 23.5 6.4 8.6 15.2 9.1 42.5 22.2 32.2 5.0 11.6 9.6 5.7 5.8 36.0 13.9 11.4 29.7 4.0 13.3 7.0 13.3 13.8 5.2 16.0 15.3 23.1 3.9 12.2 4.8 24.1 83.3 7.6 4.1 49.5 8.1 22.2 5.0 9.7 15.0 15.5 7.0 19.3 20.2 51.7 42.7 6.7 4.2 4.2 18.4 15.0 6.5 4.2 7.3 8.4 4.1 6.9 2.1 2.5 3.6 2.0 16.0 21.1 2.7 3.3 3.3 10.8 20.8 3.1 7.9 2.1 0.6 3.2 21.1 17.4 5.9 7.0 0.0 14.2 5.9 11.7 3.5 19.1 4.3 0.8 8.7 14.6 0.1 2.0 4.5 3.6 0.6 5.8 7.2 9.7 0.0 0.0 0.4 4.9 15.3 6.6 4.0 13.7 22.8 17.4 4.5 15.6 1.8 0.4 0.0 7.6 11.0 1.9 6.6 7.0 1.4 8.8 0.0 3.9 1.6 1.2 20.8 0.3 2.6 0.4 1.9 0.2 0.4 1.1 2.3 0.5 0.6 3.5 1.6 1.9 23.8 0.0 0.7 13.2 14.5 8.6 15.2 13.9 11.4 13.3 13.8 12.2 9.7 19.3 18.4 1.0 6.4 54.8 105.1 5.0 15.2 3.8 5.0 10.2 7.0 3.7 4.2 79.0 4.3 8.7 16.5 0.0 0.7 24.6 53.8 25.4 5.0 51.0 18.0 3.7 4.2 6.0 0.8 14.5 7.6 0.4 4.6 14.8 21.3 9.5 2.3 2.5 5.8 5.6 3.3 13.0 20.1 8.2 13.6 4.9 158.2 2.8 8.5 21.4 11.2 5.4 9.8 5.2 4.5 10.6 16.6 26.2 3.0 3.8 13.5 45.4 32.8 15.3 110.5 0.0 3.3 3.1 5.1 3.2 9.9 11.6 1.5 1.6 7.5 36.9 11.5 PFKFB3 ENSG00000170525 "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3" Q16875 10 6144934-6254644 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Hydrolase, Kinase, Multifunctional enzyme, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adipose tissue: 334.6;skeletal muscle: 621.3" "Cell type enhanced" "Detected in many" "Astrocytes: 153.8;Collecting duct cells: 195.0;Langerhans cells: 132.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 26.4" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "A549: 296.2;RPTEC TERT1: 181.8;T-47d: 192.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008266, CAB020795, HPA043889" Uncertain Enhanced Nucleoplasm NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 80: Striated muscle - Unknown function" "Cluster 6: T47d - Mammary gland" "Cluster 41: Macrophages - Immune response" Nucleoplasm "CAB020795: , HPA008266: AB_1855239, HPA043889: AB_2678717" "unprognostic (1.61e-1)" "unprognostic (5.08e-3)" "unprognostic (2.89e-2)" "unprognostic (6.18e-2)" "unprognostic (2.29e-1)" "unprognostic (1.79e-1)" "unprognostic (3.11e-3)" "unprognostic (1.88e-1)" "unprognostic (1.03e-1)" "unprognostic (1.04e-1)" "unprognostic (3.30e-2)" "unprognostic (7.34e-2)" "prognostic unfavorable (1.87e-7)" "unprognostic (1.89e-2)" "unprognostic (1.19e-1)" "unprognostic (1.13e-1)" "unprognostic (2.74e-1)" 334.6 22.7 66.1 72.2 81.2 246.0 153.8 75.4 66.6 30.2 22.1 22.2 19.4 24.0 11.1 51.3 37.7 59.9 21.9 62.8 105.8 243.9 32.8 67.7 24.5 145.7 100.9 24.2 21.0 10.1 39.6 20.0 100.9 20.2 8.9 31.5 40.4 49.5 621.3 53.6 22.9 16.9 90.1 50.2 26.1 13.9 91.8 15.1 10.9 30.4 28.2 63.9 40.3 105.6 22.0 296.2 23.1 18.8 85.2 10.5 12.2 31.6 22.5 22.9 35.5 14.1 78.0 37.2 20.2 13.8 18.0 69.0 24.9 50.2 26.3 44.6 17.3 22.1 16.2 5.2 7.2 21.6 32.2 7.6 16.4 39.5 9.5 58.3 44.9 25.6 16.6 13.6 18.6 35.7 15.3 20.3 22.5 31.1 20.5 34.3 11.3 14.7 181.8 11.1 21.9 8.9 22.9 24.7 45.8 39.5 192.0 25.2 57.0 23.9 22.0 3.1 38.7 27.8 10.4 33.7 65.8 25.0 37.4 2.9 7.5 7.7 2.2 9.2 5.7 1.8 4.2 2.9 4.7 1.6 3.0 3.0 26.4 1.2 5.5 2.9 4.3 4.3 66.1 81.2 75.4 66.6 62.8 105.8 145.7 100.9 100.9 90.1 91.8 105.6 37.1 76.9 55.1 153.8 27.2 102.6 16.7 21.5 37.5 6.4 37.1 36.8 19.5 22.8 32.1 195.0 52.1 0.4 37.0 14.9 0.0 54.7 5.0 41.1 18.9 32.9 8.5 1.3 42.8 25.7 6.9 30.8 33.1 64.3 44.2 72.5 8.9 15.8 20.6 6.7 19.4 6.6 18.3 88.0 132.3 9.5 2.8 122.2 46.2 41.2 19.6 0.3 4.1 14.1 31.9 59.6 5.2 7.2 25.3 4.2 5.4 2.4 19.2 1.9 0.0 58.5 24.4 0.6 2.5 20.9 63.9 1.0 61.7 12.4 8.1 14.7 PFKFB4 ENSG00000114268 "6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4" Q16877 3 48517684-48562015 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Hydrolase, Kinase, Multifunctional enzyme, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 40.3;Proximal enterocytes: 43.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "classical monocyte: 12.5;eosinophil: 21.9;intermediate monocyte: 13.8;neutrophil: 40.4;non-classical monocyte: 25.1" "Group enriched" "Detected in many" 6 "granulocytes: 40.4;monocytes: 25.1" "Cell line enhanced" "Detected in many" "hTERT-RPE1: 52.5;U-87 MG: 83.9;WM-115: 74.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA047719, HPA066058" Uncertain Approved Nucleoli NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 58: Brain - Synaptic function" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 38: Extravillous trophoblasts - Unknown function" Nucleoli "HPA047719: AB_2680129, HPA066058: AB_2685606" "unprognostic (7.60e-2)" "prognostic unfavorable (3.04e-4)" "unprognostic (1.01e-1)" "unprognostic (1.19e-1)" "unprognostic (3.90e-3)" "unprognostic (7.96e-2)" "unprognostic (1.72e-6)" "unprognostic (1.65e-1)" "unprognostic (3.75e-2)" "unprognostic (6.78e-2)" "unprognostic (3.78e-2)" "unprognostic (7.13e-2)" "prognostic unfavorable (3.91e-8)" "unprognostic (2.04e-1)" "unprognostic (6.28e-2)" "unprognostic (2.43e-3)" "unprognostic (3.35e-2)" 1.8 2.5 5.1 4.0 5.5 14.8 1.9 6.1 6.3 3.3 3.4 3.3 18.4 2.0 18.0 7.3 1.6 1.6 1.5 5.1 6.5 3.5 1.7 4.2 1.5 6.8 6.4 3.3 11.2 3.2 5.2 10.2 6.9 3.6 3.4 16.1 2.7 1.3 5.4 3.8 20.8 2.4 5.9 10.3 1.3 24.0 7.7 1.3 1.6 3.4 1.1 2.0 5.8 6.7 12.0 3.9 8.3 8.1 2.8 4.0 16.6 6.1 10.4 11.9 29.3 6.0 4.2 5.5 5.8 4.6 28.4 3.5 3.6 10.6 10.6 3.5 2.9 12.3 9.3 6.7 2.5 2.3 5.1 4.2 15.6 19.4 1.9 52.5 2.9 6.7 4.4 4.5 9.7 2.8 0.8 17.3 5.0 2.3 8.0 0.9 4.1 5.9 4.5 11.4 2.5 5.4 6.6 3.0 23.6 8.2 6.3 5.3 0.9 12.0 4.7 1.6 36.7 21.6 4.4 3.2 83.9 4.3 74.8 0.0 12.5 21.9 0.4 13.8 0.1 0.3 0.6 0.1 5.1 0.2 1.0 0.3 40.4 0.5 25.1 0.6 0.0 4.9 5.1 5.5 6.1 6.3 5.1 6.5 6.8 6.4 6.9 5.9 7.7 6.7 0.1 0.0 1.3 13.1 0.3 3.2 0.3 7.0 1.8 6.3 1.6 1.3 1.0 2.8 2.1 0.0 2.1 13.8 0.2 1.3 0.0 2.9 2.8 1.9 2.4 0.8 4.2 0.4 4.5 1.5 40.3 1.2 0.5 3.3 1.3 2.0 1.1 1.0 6.0 6.7 7.3 13.0 2.0 7.8 0.5 2.6 0.9 7.3 1.8 3.7 3.5 3.3 1.0 6.0 13.9 2.9 1.4 0.7 1.8 0.4 43.6 0.2 2.7 4.4 0.0 0.1 1.5 0.5 0.8 2.5 1.7 5.5 0.9 1.3 3.7 0.1 PFKL ENSG00000141959 "Phosphofructokinase, liver type" P17858 21 44300051-44327376 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Glycolysis "Allosteric enzyme, Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal enterocytes: 273.7;Proximal enterocytes: 331.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA030047 Approved Uncertain Nucleoli,Mitochondria NA NA 1100000 "Cluster 39: Non-specific - mRNA processing" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 25: RPMI-8226 - Immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoli, Mitochondria" "HPA030047: AB_10602815" "unprognostic (6.21e-3)" "unprognostic (2.93e-1)" "unprognostic (4.46e-2)" "unprognostic (1.23e-2)" "unprognostic (1.87e-2)" "unprognostic (1.23e-1)" "unprognostic (1.10e-1)" "unprognostic (6.98e-2)" "unprognostic (9.75e-2)" "prognostic unfavorable (4.41e-4)" "unprognostic (5.69e-2)" "unprognostic (5.40e-2)" "unprognostic (1.55e-1)" "unprognostic (4.99e-1)" "unprognostic (2.49e-1)" "unprognostic (8.06e-2)" "unprognostic (3.01e-2)" 62.7 36.1 36.5 41.6 40.3 45.2 57.3 43.8 40.7 60.0 36.0 79.5 99.9 47.9 12.9 79.7 42.9 40.9 41.5 35.6 29.7 95.4 60.6 51.0 42.1 54.0 45.6 42.6 40.0 21.1 38.8 41.7 50.3 47.6 24.9 23.8 58.5 38.1 18.8 68.7 92.2 18.6 48.4 59.6 64.6 44.7 54.3 26.0 47.7 17.8 23.1 57.5 58.2 57.7 127.9 54.8 38.4 111.2 58.0 43.2 167.6 93.9 60.2 53.3 51.9 74.5 27.5 74.9 108.8 62.5 50.3 67.6 30.3 84.4 12.3 62.9 67.7 152.5 47.2 123.4 45.1 116.1 93.1 57.0 51.0 54.5 27.0 80.6 79.2 53.9 95.9 83.7 36.9 161.3 50.8 89.9 60.2 114.0 60.2 122.1 35.7 206.6 23.9 139.0 67.0 49.7 137.3 114.9 60.7 15.4 90.9 101.6 116.7 80.4 50.9 53.0 37.1 159.7 45.6 31.1 132.9 89.7 65.4 17.7 71.5 17.2 37.8 119.0 31.2 41.0 48.9 34.4 83.4 54.5 28.3 22.9 14.0 26.1 126.8 52.4 78.5 84.2 36.5 40.3 43.8 40.7 35.6 29.7 54.0 45.6 50.3 48.4 54.3 57.7 56.2 22.4 27.9 53.2 45.3 35.7 40.3 95.2 37.0 74.6 41.3 36.6 14.4 27.1 51.6 92.0 66.7 119.6 38.7 273.7 99.7 85.5 2.3 40.7 29.6 49.0 46.3 45.6 15.7 51.4 174.8 44.6 126.4 83.1 41.9 61.2 40.7 70.0 108.6 30.3 9.3 131.4 57.0 64.7 44.5 8.2 39.1 60.0 69.4 29.0 129.4 67.6 33.0 10.1 41.7 52.7 174.2 55.7 39.2 54.9 331.6 142.4 33.7 53.6 26.3 21.3 47.8 1.8 12.2 42.3 36.1 160.8 31.8 31.2 178.6 54.2 PFKM "PFK-1, PFKX, PPP1R122" ENSG00000152556 "Phosphofructokinase, muscle" P08237 12 48105139-48146404 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Glycolysis "Allosteric enzyme, Kinase, Transferase" "Disease variant, Glycogen storage disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 5 "skeletal muscle: 1570.1;tongue: 1393.9" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 345.9;Horizontal cells: 121.1;Muller glia cells: 125.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA002117 Approved Approved "Endoplasmic reticulum" NA NA 410000 "Cluster 19: B-cells - Humoral immune response" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 54: Cardiomyocytes - Muscle contraction" "Endoplasmic reticulum" "HPA002117: AB_1855245" "unprognostic (4.60e-2)" "unprognostic (2.56e-3)" "unprognostic (2.56e-3)" "prognostic unfavorable (5.85e-6)" "unprognostic (4.97e-1)" "prognostic unfavorable (7.91e-5)" "unprognostic (5.93e-3)" "unprognostic (1.63e-1)" "unprognostic (2.80e-1)" "unprognostic (1.86e-1)" "unprognostic (2.29e-3)" "unprognostic (6.73e-2)" "prognostic favorable (2.28e-7)" "unprognostic (1.07e-1)" "unprognostic (1.53e-1)" "unprognostic (5.72e-2)" "unprognostic (1.30e-2)" 18.7 54.2 50.4 11.0 50.9 8.0 15.0 58.1 59.3 28.2 50.1 34.2 10.4 36.1 14.3 38.6 29.2 15.9 298.6 49.4 63.3 46.0 8.4 14.9 8.0 54.5 51.1 45.1 10.9 136.2 36.5 12.0 58.7 29.0 16.1 85.5 29.2 39.0 1570.1 14.4 16.0 35.1 46.1 11.8 23.0 50.7 62.1 9.3 21.5 1393.9 10.2 27.7 19.2 43.4 32.9 30.6 98.4 87.5 97.2 72.5 20.2 85.4 80.2 77.1 54.4 76.3 40.5 192.9 69.6 44.1 44.9 36.0 90.1 91.2 70.9 5.5 43.9 54.7 64.7 1.9 54.3 2.9 30.9 102.1 50.4 69.2 107.3 125.1 85.9 3.7 64.6 91.7 71.5 25.8 69.5 5.1 67.7 36.0 93.9 115.7 55.7 141.3 48.4 32.5 111.5 82.6 51.0 75.9 86.5 78.7 80.3 11.2 75.8 34.0 46.5 49.5 72.1 52.8 145.3 106.4 62.4 6.8 28.5 0.3 2.9 7.8 2.1 2.5 0.9 8.8 3.5 2.1 5.6 8.3 4.3 2.4 0.7 2.1 2.1 0.9 3.5 3.1 50.4 50.9 58.1 59.3 49.4 63.3 54.5 51.1 58.7 46.1 62.1 43.4 8.6 16.0 8.4 30.3 6.9 7.4 21.7 22.1 15.9 43.3 5.6 9.1 345.9 12.8 10.8 22.0 43.8 2.8 0.9 3.4 66.5 10.6 43.1 5.5 18.0 17.3 9.1 8.6 23.2 2.5 3.8 27.1 6.6 2.4 1.3 17.3 13.9 2.7 4.1 121.1 30.0 9.1 34.6 3.8 3.7 27.0 30.7 4.3 55.2 3.7 11.3 125.7 4.1 15.6 3.4 3.5 1.9 47.8 4.6 7.9 2.7 30.6 11.2 51.1 26.3 37.6 24.5 52.1 14.4 9.2 5.3 2.5 3.3 24.0 10.1 9.7 PFKP "PFK-C, PFKF" ENSG00000067057 "Phosphofructokinase, platelet" Q01813 10 3066333-3137718 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Glycolysis "Allosteric enzyme, Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "retina: 277.0" "Cell type enhanced" "Detected in many" "Early spermatids: 459.8;Late spermatids: 516.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018257, HPA056484" Uncertain Supported Cytosol No No 1900000 "Cluster 10: Basophils - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 34: Spermatids - Unknown function" Cytosol "HPA018257: AB_10960391, HPA056484: AB_2683147" "unprognostic (1.16e-1)" "unprognostic (2.41e-3)" "unprognostic (5.79e-2)" "unprognostic (1.74e-1)" "unprognostic (1.40e-1)" "prognostic unfavorable (1.55e-4)" "prognostic unfavorable (8.72e-6)" "unprognostic (1.36e-3)" "unprognostic (2.38e-1)" "unprognostic (8.51e-2)" "unprognostic (2.37e-2)" "unprognostic (8.82e-2)" "unprognostic (6.02e-3)" "unprognostic (2.60e-2)" "unprognostic (9.74e-2)" "unprognostic (2.06e-1)" "unprognostic (4.54e-3)" 35.0 11.5 41.6 41.5 39.3 14.4 23.5 13.8 49.9 26.3 61.7 43.8 48.8 55.5 5.6 67.1 34.9 34.1 128.6 60.4 65.0 44.6 4.7 19.1 32.5 30.7 50.9 19.1 15.9 15.2 29.9 15.5 58.0 35.6 30.7 277.0 39.8 62.0 70.4 40.3 59.6 44.1 8.3 19.1 36.8 141.1 47.0 29.7 38.5 21.0 21.2 64.7 42.8 31.7 314.8 420.2 25.9 0.6 26.8 56.9 336.9 187.2 66.6 186.2 222.8 444.5 320.4 37.0 147.8 134.9 174.9 243.0 141.7 292.3 173.1 102.1 111.0 132.0 189.1 24.2 65.2 53.7 203.4 27.0 61.2 190.0 96.0 273.7 367.8 153.7 37.0 1.3 195.7 239.8 182.5 44.4 42.9 133.9 149.3 138.8 46.9 150.1 185.7 115.9 69.5 64.7 133.7 111.0 172.0 307.8 93.7 80.3 449.2 124.6 65.3 380.5 199.3 195.4 200.1 135.7 331.0 98.0 78.5 30.8 8.5 2.9 26.8 4.2 21.2 13.7 26.2 25.0 14.5 15.3 9.6 15.4 1.3 26.7 1.6 22.5 37.6 16.5 41.6 39.3 13.8 49.9 60.4 65.0 30.7 50.9 58.0 8.3 47.0 31.7 30.5 3.2 7.0 128.6 14.8 28.7 58.5 96.8 14.8 40.4 10.3 7.7 147.4 8.6 57.9 64.4 54.2 7.8 16.3 72.6 43.0 115.7 459.8 41.2 9.0 36.0 37.2 10.3 49.4 10.8 205.8 25.9 35.7 63.8 55.9 25.8 14.6 0.7 33.9 42.1 25.9 23.1 124.1 7.6 31.4 516.3 7.5 14.3 19.6 15.0 15.4 113.1 16.5 16.1 6.7 116.8 57.2 6.8 14.2 80.9 53.2 5.9 62.6 133.4 13.1 43.2 34.6 149.4 3.5 25.1 22.6 26.5 28.8 11.2 28.9 64.2 PGGT1B "BGGI, GGTI" ENSG00000164219 "Protein geranylgeranyltransferase type I subunit beta" P53609 5 115204012-115262877 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Prenyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Rod photoreceptor cells: 111.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA030646 Uncertain Approved "Nucleoplasm,Endoplasmic reticulum,Cytosol" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 14: B-cells - Humoral immune response" "Cluster 44: HDLM-2 - Immune response" "Cluster 46: Photoreceptor cells - Phototransduction" "Nucleoplasm, Endoplasmic reticulum" Cytosol "HPA030646: AB_10602019" "unprognostic (2.73e-2)" "unprognostic (1.67e-1)" "unprognostic (3.92e-2)" "unprognostic (7.34e-2)" "unprognostic (5.57e-2)" "unprognostic (7.56e-3)" "unprognostic (1.34e-1)" "unprognostic (1.75e-1)" "unprognostic (3.25e-2)" "unprognostic (1.33e-1)" "unprognostic (2.17e-1)" "unprognostic (2.48e-1)" "unprognostic (4.38e-2)" "unprognostic (1.58e-1)" "unprognostic (3.75e-1)" "unprognostic (5.93e-3)" "unprognostic (1.15e-2)" 9.4 8.1 4.6 11.1 6.1 12.8 9.6 6.1 4.2 7.6 5.6 14.6 13.0 8.0 3.6 9.6 7.5 7.4 6.7 4.2 5.9 8.1 12.8 7.4 9.8 5.3 5.9 7.3 9.6 12.6 3.2 8.3 6.4 8.4 15.1 12.0 6.6 5.9 7.8 4.9 11.1 9.8 5.8 10.3 11.7 5.6 5.6 9.4 8.6 9.1 11.0 11.3 5.4 6.8 14.7 15.6 17.5 22.7 10.0 8.3 8.6 17.7 10.4 14.5 14.8 17.1 15.3 29.6 23.4 12.4 14.9 11.2 23.3 23.3 21.5 32.9 12.9 17.1 21.0 13.9 13.3 23.7 24.2 12.5 14.0 14.3 14.8 9.2 14.7 17.2 14.1 12.3 16.7 22.8 20.9 7.9 13.0 16.4 12.0 22.6 23.3 30.3 15.2 27.3 17.0 13.0 21.0 15.8 17.6 10.4 21.2 17.4 17.0 14.8 14.0 10.3 20.9 20.4 24.5 15.5 10.7 24.1 20.9 13.7 19.0 34.1 7.0 25.3 8.0 9.7 7.8 8.9 17.2 11.3 7.4 6.8 19.5 10.5 27.0 15.5 7.6 10.3 4.6 6.1 6.1 4.2 4.2 5.9 5.3 5.9 6.4 5.8 5.6 6.8 21.8 12.8 20.8 24.8 26.2 9.9 11.8 12.2 9.1 23.3 18.3 10.4 17.1 5.7 18.3 16.5 47.9 15.3 27.2 29.0 27.4 19.3 49.2 15.8 21.3 20.3 30.1 9.5 30.5 21.6 14.9 15.5 19.9 13.5 23.5 17.2 20.7 25.7 22.6 23.5 27.6 22.4 10.2 21.9 13.2 10.2 13.4 24.8 10.6 33.7 26.8 27.8 24.7 38.2 38.0 24.0 27.2 15.4 12.0 15.6 20.7 22.8 20.3 111.2 13.1 20.5 16.7 14.7 13.9 10.7 12.4 13.5 16.1 19.6 23.9 20.3 PGK1 ENSG00000102144 "Phosphoglycerate kinase 1" P00558 X 77910739-78129295 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Glycolysis "Kinase, Transferase" "Disease variant, Hereditary hemolytic anemia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Basal respiratory cells: 1126.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010065, HPA045385, HPA073644, HPA073656" Approved NA NA 170000000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 8: Non-specific - Mitochondria" "Cluster 16: U-266 - Nucleosome" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "CAB010065: AB_628116, HPA045385: AB_2679306, HPA073644: AB_2732231, HPA073656: AB_2732235" "prognostic unfavorable (7.05e-8)" "prognostic unfavorable (2.69e-5)" "unprognostic (1.21e-1)" "unprognostic (8.30e-2)" "unprognostic (1.10e-1)" "prognostic unfavorable (2.65e-6)" "prognostic unfavorable (2.74e-4)" "unprognostic (1.13e-2)" "unprognostic (1.27e-1)" "unprognostic (6.66e-2)" "prognostic unfavorable (8.34e-4)" "unprognostic (5.66e-2)" "unprognostic (2.99e-1)" "unprognostic (8.99e-3)" "unprognostic (3.58e-1)" "unprognostic (2.90e-2)" "unprognostic (6.57e-2)" 120.7 141.8 87.3 149.0 94.1 252.8 89.1 103.2 119.0 100.2 117.2 127.4 123.4 72.3 73.0 154.1 79.3 110.1 247.4 92.7 109.2 233.5 143.8 117.1 139.0 104.8 95.1 61.9 61.1 188.8 30.0 138.6 109.5 92.8 143.1 298.8 93.2 101.8 452.0 92.6 119.1 116.7 102.4 97.2 86.1 29.2 111.1 158.3 105.6 266.7 189.6 148.4 49.4 101.3 943.0 426.7 139.7 283.8 236.1 190.0 331.3 469.2 324.0 402.9 670.0 390.2 287.7 373.9 473.7 326.5 479.5 397.6 624.8 729.3 800.7 229.8 246.6 290.3 657.8 341.8 258.0 671.8 309.2 238.5 302.2 366.7 192.7 646.1 418.8 361.9 308.5 553.4 557.4 371.2 593.5 506.0 433.3 628.5 800.7 421.8 374.4 1157.0 423.8 385.4 208.0 286.6 486.3 409.0 422.9 352.6 214.8 347.9 340.2 428.1 294.3 433.4 329.0 609.5 1221.7 391.5 1207.0 750.5 286.6 170.6 360.2 321.1 121.9 382.0 135.9 128.4 144.3 132.9 333.7 101.2 130.9 140.7 281.9 140.3 527.0 130.2 168.4 606.0 87.3 94.1 103.2 119.0 92.7 109.2 104.8 95.1 109.5 102.4 111.1 101.3 166.3 150.6 168.6 20.2 174.8 144.3 272.2 1126.6 122.3 211.3 72.4 67.2 480.4 140.2 436.9 174.7 77.2 298.4 200.6 196.5 471.6 715.8 19.3 123.7 112.4 182.3 102.4 95.9 32.5 236.4 746.4 131.3 95.3 145.1 195.5 98.1 139.6 200.2 499.0 309.6 37.0 164.3 518.8 298.4 188.8 12.1 94.8 310.4 167.2 25.3 499.3 245.7 131.8 20.1 21.9 510.2 149.9 127.2 214.8 118.3 221.5 566.0 235.6 188.8 124.9 84.0 191.8 8.8 57.4 138.4 119.1 349.6 251.9 278.7 203.5 225.8 PGK2 "PGK-2, PGKPS" ENSG00000170950 "Phosphoglycerate kinase 2" P07205 6 49785660-49787285 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Glycolysis "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 531 "testis: 199.9" "Group enriched" "Detected in some" 9 "Early spermatids: 1143.9;Late spermatids: 2784.5" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA045385, HPA073644, HPA073656" Supported NA NA "Cluster 36: Testis - Spermatogenesis" "Cluster 31: Spermatids - Spermatogenesis" "HPA045385: AB_2679306, HPA073644: AB_2732231, HPA073656: AB_2732235" "unprognostic (8.87e-3)" "unprognostic (5.02e-1)" "unprognostic (1.24e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 199.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1143.9 0.0 0.1 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2784.5 14.6 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.7 0.0 0.0 0.0 0.0 0.0 0.0 6.6 0.0 0.0 204.0 8.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PGM2L1 "BM32A, FLJ32029" ENSG00000165434 "Phosphoglucomutase 2 like 1" Q6PCE3 11 74330316-74398433 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Carbohydrate metabolism, Glucose metabolism" "Isomerase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 23.1" "Cell type enhanced" "Detected in many" "Excitatory neurons: 90.1;Exocrine glandular cells: 124.5;Pancreatic endocrine cells: 140.1;Respiratory ciliated cells: 95.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HUVEC TERT2: 16.6;LHCN-M2: 19.9;RH-30: 18.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA056995, HPA060948" Enhanced Approved Mitochondria No No 140000 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 10: Brain - Neuronal signaling" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 1: Pancreatic cells - Digestion" Mitochondria "HPA056995: AB_2683305, HPA060948: AB_2684394" "unprognostic (7.44e-3)" "unprognostic (1.33e-1)" "unprognostic (7.28e-3)" "unprognostic (8.91e-2)" "unprognostic (6.16e-2)" "unprognostic (1.55e-1)" "unprognostic (7.16e-6)" "unprognostic (1.43e-1)" "unprognostic (1.95e-1)" "unprognostic (5.97e-3)" "unprognostic (1.70e-2)" "unprognostic (2.98e-1)" "unprognostic (9.33e-3)" "unprognostic (3.71e-1)" "unprognostic (1.97e-1)" "unprognostic (3.04e-1)" "unprognostic (1.03e-2)" 1.9 2.6 17.6 3.7 22.1 3.2 1.9 0.0 21.5 4.9 0.0 3.2 1.3 4.4 0.8 1.0 3.2 3.3 1.1 23.1 16.2 1.6 1.0 1.8 3.0 1.9 4.5 0.9 3.1 0.7 3.9 1.1 2.2 2.9 3.5 2.6 2.6 1.3 5.9 0.7 1.5 4.0 0.3 1.5 2.1 1.3 5.7 8.1 2.7 11.1 2.7 6.4 1.9 7.8 2.7 3.8 14.5 2.7 4.3 1.9 0.4 3.5 2.6 3.0 3.3 1.4 6.8 0.3 8.5 2.3 5.3 1.3 2.9 0.7 2.8 1.1 1.5 2.1 2.0 1.1 0.5 2.4 3.2 1.0 0.7 6.8 1.2 3.2 16.6 5.0 2.8 1.8 19.9 0.3 9.9 2.1 2.9 2.0 3.3 3.1 18.9 0.1 7.8 0.5 0.7 2.9 5.7 1.3 2.6 3.9 0.2 0.4 14.0 6.6 6.0 2.7 3.7 2.4 3.8 0.3 0.6 3.4 1.6 1.2 0.3 0.5 0.9 0.3 1.3 1.1 1.6 1.1 0.2 0.8 1.5 0.8 0.3 1.4 0.2 0.8 3.9 0.5 17.6 22.1 0.0 21.5 23.1 16.2 1.9 4.5 2.2 0.3 5.7 7.8 19.6 6.4 6.4 8.5 20.9 7.6 41.2 14.3 10.8 23.9 26.5 19.4 7.3 17.2 30.2 9.2 16.7 0.6 17.6 13.8 5.9 37.4 14.1 28.1 23.5 32.1 11.9 47.5 90.1 124.5 5.3 21.0 7.1 25.5 8.2 16.1 29.3 1.0 5.4 8.4 64.8 16.2 18.3 23.0 21.6 3.6 2.5 9.9 16.0 20.6 4.6 4.4 12.3 14.6 7.1 140.1 9.3 3.8 13.4 50.4 4.2 5.3 95.4 11.0 26.3 21.3 16.7 34.2 21.2 9.0 5.3 0.1 25.0 8.8 20.9 55.6 PGS1 DKFZP762M186 ENSG00000087157 "Phosphatidylglycerophosphate synthase 1" Q32NB8 17 78378649-78425114 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA022526 Approved NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 52: Non-specific - Transcription" "HPA022526: AB_1855271" "unprognostic (1.19e-2)" "unprognostic (1.12e-1)" "unprognostic (3.48e-1)" "unprognostic (1.86e-3)" "unprognostic (1.35e-2)" "unprognostic (1.71e-2)" "prognostic unfavorable (1.37e-4)" "unprognostic (5.76e-3)" "unprognostic (3.17e-2)" "unprognostic (8.46e-3)" "prognostic favorable (7.33e-5)" "prognostic unfavorable (9.94e-4)" "prognostic unfavorable (1.16e-5)" "unprognostic (9.94e-2)" "unprognostic (5.60e-2)" "unprognostic (1.33e-1)" "unprognostic (2.72e-2)" 16.1 10.0 12.6 17.9 14.9 39.6 15.4 13.3 25.3 14.2 15.8 13.0 11.7 14.9 6.0 10.8 14.0 13.2 11.1 13.0 16.6 13.8 7.0 23.5 16.9 18.0 15.4 13.9 10.9 11.5 11.5 19.7 15.6 12.4 7.8 6.6 11.9 10.8 13.5 11.5 14.7 10.3 12.9 19.8 11.4 8.9 18.8 14.0 16.4 7.6 11.6 14.5 12.0 18.1 19.9 16.7 17.8 13.5 14.6 23.0 18.8 18.3 17.2 19.3 21.2 17.8 15.8 20.2 10.8 10.8 19.4 15.5 19.8 12.5 15.1 30.3 24.1 22.2 25.0 17.5 15.2 17.7 16.9 23.6 16.1 14.6 12.6 19.1 37.8 15.9 26.0 14.2 13.2 10.8 39.5 19.5 17.4 8.5 15.9 19.4 29.6 16.8 21.0 19.5 21.4 33.2 15.4 16.4 18.5 17.8 17.4 23.8 22.8 24.9 16.6 13.5 15.4 16.0 9.5 15.2 19.1 19.0 18.7 2.1 17.7 19.3 11.0 15.0 13.6 10.3 11.6 11.7 20.6 11.9 14.5 10.6 33.9 11.2 7.2 9.4 15.1 12.0 12.6 14.9 13.3 25.3 13.0 16.6 18.0 15.4 15.6 12.9 18.8 18.1 25.9 12.8 16.8 10.1 11.6 4.5 12.0 16.3 7.4 13.0 6.4 8.8 5.8 4.3 12.0 12.9 2.1 20.2 11.2 7.7 3.9 5.8 20.0 9.0 8.7 21.5 4.2 5.5 14.8 7.0 8.1 9.7 12.2 6.7 7.6 13.3 15.0 3.9 15.4 20.2 15.0 6.1 6.1 13.9 8.3 10.8 10.5 19.2 5.4 17.8 12.1 11.0 10.3 11.6 20.4 7.2 15.6 8.6 9.4 9.2 8.0 5.2 14.4 11.4 32.9 6.8 10.8 17.9 18.4 5.8 3.8 19.3 10.8 14.7 8.5 10.9 PHKG1 PHKG ENSG00000164776 "Phosphorylase kinase catalytic subunit gamma 1" Q16816 7 56080283-56092996 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Carbohydrate metabolism, Glycogen metabolism" "Calmodulin-binding, Kinase, Muscle protein, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in many" 12 "skeletal muscle: 264.6;tongue: 172.3" "Cell type enhanced" "Detected in many" "Cholangiocytes: 48.6;Hepatocytes: 46.5" "Cancer enriched" "Detected in many" 18 "glioma: 23.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in some" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA012057 Enhanced NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 80: Striated muscle - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 37: Myocytes - Muscle contraction" "HPA012057: AB_1855305" "unprognostic (2.00e-3)" "unprognostic (1.09e-1)" "unprognostic (7.09e-3)" "unprognostic (5.87e-3)" "unprognostic (2.19e-1)" "unprognostic (1.54e-2)" "unprognostic (1.31e-1)" "unprognostic (6.69e-3)" "unprognostic (2.10e-1)" "unprognostic (1.99e-1)" "unprognostic (9.14e-4)" "unprognostic (1.92e-1)" "unprognostic (7.97e-9)" "unprognostic (6.61e-3)" "unprognostic (2.34e-1)" "unprognostic (1.12e-2)" "unprognostic (3.85e-2)" 4.0 4.1 11.4 0.7 15.0 1.7 2.8 14.8 11.6 1.8 8.8 8.5 1.1 1.3 0.7 5.2 1.9 1.6 18.7 11.8 15.6 1.1 1.6 1.7 0.8 17.6 17.5 1.8 1.2 0.9 2.4 0.3 15.3 2.3 0.7 0.9 5.2 0.5 264.6 3.3 2.5 1.1 16.6 1.5 1.6 1.0 16.9 0.7 2.0 172.3 0.9 4.1 1.2 15.4 1.1 0.8 0.2 0.7 1.1 2.0 0.6 0.1 0.2 0.4 0.3 0.3 0.5 0.3 0.2 0.3 0.5 0.6 0.5 0.1 0.3 0.3 0.9 0.3 1.5 0.3 0.2 0.6 1.2 1.2 0.8 0.5 0.2 0.3 0.0 0.8 0.9 1.5 0.0 0.5 0.9 2.4 0.3 0.3 0.5 0.5 0.0 0.3 0.2 0.8 0.6 0.6 0.1 0.8 0.0 0.1 0.4 0.8 0.3 0.2 0.6 1.7 0.5 0.6 0.3 0.9 0.4 0.6 0.4 0.1 0.1 0.0 0.1 0.0 0.4 0.0 0.2 0.0 0.0 0.2 0.1 0.1 0.7 0.0 0.1 0.1 0.1 0.0 11.4 15.0 14.8 11.6 11.8 15.6 17.6 17.5 15.3 16.6 16.9 15.4 12.6 12.8 4.2 16.0 10.4 1.3 7.7 0.2 0.6 3.9 25.6 6.7 1.7 48.6 3.7 27.6 0.0 7.5 17.7 9.0 1.9 14.6 2.7 20.8 11.3 8.2 16.7 6.6 3.1 12.3 14.5 10.4 2.6 16.4 8.2 4.6 23.6 46.5 12.1 11.8 3.8 12.6 0.0 36.8 1.2 5.9 18.0 8.9 1.8 3.7 10.7 5.0 8.2 3.5 5.2 11.0 10.1 16.1 5.2 11.6 17.8 16.8 2.2 5.4 13.1 34.0 7.2 11.1 9.1 1.2 1.0 7.3 8.2 3.7 24.1 8.4 PHKG2 ENSG00000156873 "Phosphorylase kinase catalytic subunit gamma 2" P15735 16 30748293-30761176 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Carbohydrate metabolism, Glycogen metabolism" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Glycogen storage disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 4 "testis: 130.1" "Group enriched" "Detected in many" 5 "Early spermatids: 397.0;Late spermatids: 1576.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA065618, HPA068751" Supported Cytosol NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 78: Testis - Spermatogenesis" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 25: Spermatids - Spermatogenesis" Cytosol "HPA065618: AB_2685520, HPA068751: AB_2686025" "unprognostic (7.63e-3)" "prognostic favorable (7.90e-4)" "prognostic unfavorable (9.92e-4)" "unprognostic (1.08e-1)" "unprognostic (1.25e-1)" "unprognostic (5.81e-2)" "unprognostic (3.72e-2)" "prognostic favorable (1.90e-4)" "unprognostic (6.45e-2)" "unprognostic (1.25e-2)" "prognostic favorable (8.02e-4)" "unprognostic (6.15e-2)" "unprognostic (5.27e-2)" "unprognostic (1.36e-2)" "unprognostic (2.41e-1)" "unprognostic (2.18e-2)" "unprognostic (3.03e-2)" 9.0 15.8 17.5 11.5 16.9 30.0 9.9 17.1 18.7 10.0 15.9 12.9 11.0 10.1 9.5 10.2 11.7 8.2 12.1 18.9 16.4 14.7 19.1 10.0 12.5 17.7 17.2 8.3 9.7 18.9 15.9 7.8 18.8 14.7 12.0 8.9 11.5 12.0 13.2 14.6 12.0 9.9 16.0 12.9 13.8 130.1 17.5 11.6 13.6 8.8 12.7 10.1 9.2 16.2 24.7 16.3 13.1 16.2 11.8 9.4 29.8 17.2 24.6 22.1 25.1 13.5 12.6 21.0 19.3 17.1 11.5 24.0 13.5 21.5 17.6 11.4 38.2 11.9 28.8 38.7 18.1 18.1 16.9 12.9 11.2 21.4 9.9 10.7 22.8 15.3 16.1 11.7 16.3 55.5 22.3 27.1 18.0 17.6 18.0 29.4 20.0 28.2 25.7 27.2 17.5 11.9 13.5 38.1 16.6 11.8 30.1 15.5 13.6 14.4 15.1 17.2 16.0 24.1 14.4 14.8 27.3 35.2 11.4 44.0 55.8 114.9 37.8 56.5 30.9 21.1 27.1 38.8 52.0 21.5 24.2 27.7 44.7 63.8 42.3 46.1 43.3 49.0 17.5 16.9 17.1 18.7 18.9 16.4 17.7 17.2 18.8 16.0 17.5 16.2 10.4 12.8 21.7 13.7 18.5 21.0 15.2 28.7 22.8 8.8 21.8 17.1 15.9 10.0 32.0 18.4 10.4 29.6 32.2 32.1 27.4 11.9 397.0 35.8 13.0 10.0 16.3 20.2 14.7 24.4 41.5 11.8 44.4 38.8 13.3 16.1 10.4 24.1 28.2 20.2 14.5 21.4 26.4 19.1 27.2 1576.6 17.4 26.4 12.4 11.2 40.3 13.7 39.1 9.0 8.1 19.6 18.5 23.3 20.5 31.5 27.8 47.3 33.0 9.9 0.0 8.9 14.8 180.5 22.9 20.5 23.0 75.5 25.9 20.8 27.0 16.9 PI4K2A "DKFZP761G1923, PI4KII, PIK42A" ENSG00000155252 "Phosphatidylinositol 4-kinase type 2 alpha" Q9BTU6 10 97640686-97676434 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Hofbauer cells: 38.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB030649, HPA076857" Approved Approved "Plasma membrane" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 30: Epithelial cell lines - Translation" "Cluster 4: Macrophages - Innate immune response" "Plasma membrane" "CAB030649: , HPA076857: AB_2686817" "unprognostic (1.34e-1)" "unprognostic (3.50e-2)" "prognostic unfavorable (4.21e-5)" "unprognostic (1.80e-2)" "unprognostic (2.12e-1)" "unprognostic (1.75e-2)" "unprognostic (2.84e-3)" "unprognostic (1.60e-2)" "unprognostic (1.39e-3)" "unprognostic (1.38e-2)" "unprognostic (1.02e-2)" "unprognostic (1.65e-1)" "unprognostic (9.92e-2)" "unprognostic (1.27e-1)" "unprognostic (1.80e-1)" "unprognostic (1.45e-1)" "unprognostic (2.90e-1)" 12.0 25.7 15.5 10.0 15.1 24.1 9.3 15.1 18.9 12.6 13.4 10.7 9.8 12.7 13.0 20.7 9.6 14.0 14.2 15.5 17.8 12.6 15.0 14.2 11.2 20.2 18.8 10.0 8.4 16.6 15.8 18.0 22.0 10.9 8.7 12.9 10.5 10.4 12.7 17.4 10.8 13.0 15.8 14.6 9.4 10.8 17.3 9.8 9.5 13.0 10.6 14.5 12.7 15.2 28.7 21.3 17.2 30.7 36.0 25.8 13.8 28.0 61.5 43.3 45.7 19.4 27.7 10.4 16.2 35.8 31.8 27.1 19.3 55.9 35.8 12.6 16.4 9.3 14.6 17.7 34.5 8.4 12.7 27.3 46.9 45.4 80.1 47.4 22.4 19.9 14.7 16.5 30.4 14.6 18.4 6.4 11.1 14.7 19.8 8.6 17.8 10.3 29.7 26.6 5.8 18.9 23.9 5.9 35.5 24.0 16.4 13.2 25.0 20.6 15.2 24.6 22.1 14.6 18.4 16.9 38.1 5.0 6.8 0.0 1.2 0.0 1.3 0.8 1.0 1.4 0.5 1.1 1.3 0.6 0.4 0.9 0.4 0.7 0.6 0.6 1.2 0.6 15.5 15.1 15.1 18.9 15.5 17.8 20.2 18.8 22.0 15.8 17.3 15.2 4.9 3.2 5.4 9.8 12.0 13.4 4.5 6.5 8.0 14.7 10.7 8.9 10.4 10.0 4.3 5.5 12.5 14.0 12.5 8.6 3.9 4.9 2.4 6.8 15.4 6.9 3.0 8.2 10.9 4.9 6.4 12.0 7.1 7.6 1.3 5.7 3.6 9.9 38.1 11.8 10.9 4.0 6.1 15.0 24.7 2.2 4.4 19.0 10.6 12.2 15.0 8.0 18.6 5.5 6.0 7.2 0.8 9.1 9.4 5.8 9.0 7.3 4.8 15.1 6.6 11.9 8.0 11.0 6.1 6.3 14.3 27.1 9.7 12.4 3.6 7.8 PI4K2B "FLJ11105, PI4KIIB, PIK42B" ENSG00000038210 "Phosphatidylinositol 4-kinase type 2 beta" Q8TCG2 4 25160663-25279204 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 57.9" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA004099 Enhanced Supported Cytosol NA NA "Cluster 46: Basophils - DNA binding" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 55: Plasma cells - Humoral immune response" Cytosol "HPA004099: AB_1855353" "unprognostic (1.02e-1)" "unprognostic (6.34e-3)" "prognostic favorable (9.64e-5)" "unprognostic (2.75e-2)" "unprognostic (1.98e-2)" "unprognostic (2.68e-2)" "unprognostic (7.54e-2)" "unprognostic (7.75e-2)" "unprognostic (5.06e-1)" "unprognostic (6.39e-3)" "unprognostic (1.71e-1)" "unprognostic (1.32e-1)" "unprognostic (9.07e-2)" "unprognostic (9.61e-2)" "unprognostic (2.39e-2)" "unprognostic (2.02e-2)" "unprognostic (4.47e-2)" 7.9 8.9 3.4 14.0 3.9 14.1 16.5 3.6 4.5 11.4 5.8 18.7 39.0 8.0 5.8 16.7 8.7 8.3 4.5 3.2 4.1 12.9 57.9 16.5 18.1 4.3 3.6 5.2 9.5 7.7 3.4 12.0 4.5 11.4 20.4 4.9 23.5 7.9 2.4 13.1 31.6 9.1 4.5 13.5 22.7 12.1 3.7 19.7 24.1 4.8 18.9 14.3 8.1 5.3 33.8 9.9 16.7 14.6 18.2 33.9 31.3 50.8 48.6 48.4 58.1 14.0 37.7 86.3 11.5 45.3 37.5 14.7 37.3 24.6 41.7 28.9 12.2 30.4 23.3 26.1 14.2 61.9 21.0 21.6 17.9 18.6 19.2 12.9 28.0 27.0 20.7 76.2 37.0 18.8 58.3 39.7 23.6 40.5 13.6 34.4 58.1 47.5 32.2 32.2 28.9 6.2 24.5 17.1 12.0 17.0 25.7 27.3 33.8 31.8 8.4 18.3 32.5 76.3 49.5 77.4 34.5 45.4 30.6 5.3 1.1 3.4 1.5 1.2 1.0 1.4 1.5 1.5 0.8 1.2 1.2 1.4 1.7 0.9 0.9 1.5 3.5 0.6 3.4 3.9 3.6 4.5 3.2 4.1 4.3 3.6 4.5 4.5 3.7 5.3 5.6 6.4 18.5 21.5 14.9 15.0 15.8 9.9 8.0 2.1 8.4 5.3 0.0 5.7 12.2 9.2 0.0 21.6 6.7 20.2 5.9 5.5 1.0 10.0 3.4 7.1 8.4 25.7 8.7 7.1 12.6 6.1 16.3 8.5 0.0 3.5 6.8 40.4 10.3 1.7 13.7 13.7 8.2 15.4 13.9 1.0 4.4 8.6 5.4 11.2 10.3 0.7 4.1 30.2 20.1 5.8 8.2 4.5 27.4 14.1 16.8 20.3 10.4 3.4 0.0 5.3 7.2 9.6 10.3 18.3 15.6 13.5 10.3 4.4 13.9 18.2 PI4KA "PI4K-ALPHA, pi4K230, PIK4CA" ENSG00000241973 "Phosphatidylinositol 4-kinase alpha" P42356 22 20707691-20859417 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 209.1;Inhibitory neurons: 127.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "K-562: 130.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009092, HPA075515" Approved Approved "Nucleoplasm,Plasma membrane" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 10: Brain - Neuronal signaling" "Cluster 1: K-562 - Erythropoiesis" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "Plasma membrane" "CAB009092: AB_2164033, HPA075515: AB_2686753" "unprognostic (8.06e-2)" "unprognostic (1.53e-1)" "unprognostic (1.20e-2)" "unprognostic (4.45e-2)" "unprognostic (1.21e-1)" "unprognostic (5.01e-3)" "unprognostic (3.19e-2)" "prognostic favorable (5.24e-4)" "unprognostic (2.08e-1)" "unprognostic (4.21e-2)" "unprognostic (1.88e-2)" "unprognostic (1.29e-1)" "prognostic favorable (7.22e-5)" "unprognostic (1.37e-1)" "unprognostic (1.33e-1)" "unprognostic (2.35e-1)" "unprognostic (1.50e-1)" 18.8 21.6 45.2 19.2 61.0 24.1 16.8 2.1 74.4 20.4 9.6 23.7 15.8 24.2 9.9 14.3 19.5 13.5 21.5 65.3 9.0 21.3 25.2 19.1 20.5 14.6 4.8 21.4 18.7 34.5 25.2 17.9 14.5 19.5 14.9 27.7 16.5 16.9 23.6 15.1 22.9 21.9 0.0 21.0 26.0 25.7 8.6 34.3 18.0 15.9 18.0 22.2 16.9 43.3 24.5 20.2 17.4 26.3 48.7 29.1 24.9 21.6 32.6 31.3 30.4 15.9 10.2 45.6 12.6 43.9 30.7 21.1 33.4 20.9 19.0 38.9 50.9 47.1 27.1 18.3 24.3 47.0 36.1 26.2 12.9 26.7 14.7 20.4 25.8 13.8 130.2 37.6 24.6 33.8 41.6 16.0 13.8 43.4 20.6 41.1 38.1 8.5 17.3 38.3 42.6 31.0 28.4 32.6 22.6 24.3 27.6 21.3 26.2 56.4 29.1 21.1 18.5 28.6 31.3 35.8 37.4 33.2 24.1 2.1 3.7 5.3 3.2 3.8 3.1 3.4 3.6 3.9 2.5 3.4 3.6 5.0 5.1 7.0 3.3 8.5 4.3 2.2 45.2 61.0 2.1 74.4 65.3 9.0 14.6 4.8 14.5 0.0 8.6 43.3 13.0 12.8 30.4 65.6 14.7 10.1 6.5 7.6 9.6 35.8 17.2 14.4 30.2 20.0 10.5 7.3 47.9 17.8 21.5 19.7 1.9 9.7 36.5 10.3 17.9 15.5 19.2 12.4 209.1 6.3 19.6 15.6 38.7 15.8 12.0 13.8 11.4 19.7 20.1 37.0 127.4 16.7 10.2 21.0 12.6 25.3 19.9 20.2 10.6 39.4 10.9 23.1 16.5 50.3 88.4 8.9 9.7 24.0 15.5 10.1 23.8 10.3 9.6 25.4 26.3 14.5 19.3 35.3 29.6 14.1 9.8 20.0 15.3 26.1 14.3 8.9 PI4KB "PI4K-BETA, pi4K92, PIK4CB" ENSG00000143393 "Phosphatidylinositol 4-kinase beta" Q9UBF8 1 151291797-151327715 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Host-virus interaction" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006280, HPA006281, CAB022071" Approved Supported "Golgi apparatus" NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 59: Non-specific - Transcription" "Golgi apparatus" "CAB022071: , HPA006280: AB_1079613, HPA006281: AB_1079614" "unprognostic (1.17e-1)" "unprognostic (1.57e-1)" "unprognostic (5.42e-3)" "unprognostic (5.23e-3)" "unprognostic (7.32e-2)" "unprognostic (1.36e-2)" "prognostic unfavorable (2.97e-4)" "unprognostic (1.87e-1)" "unprognostic (3.94e-1)" "unprognostic (1.58e-1)" "prognostic favorable (1.25e-5)" "unprognostic (8.51e-2)" "prognostic unfavorable (3.23e-4)" "unprognostic (2.53e-1)" "unprognostic (2.16e-1)" "prognostic unfavorable (6.78e-4)" "unprognostic (7.08e-2)" 45.6 45.0 57.3 33.1 61.4 78.0 47.6 64.4 63.2 62.6 53.2 50.9 35.8 58.8 54.8 48.0 58.6 40.2 45.8 59.2 62.3 50.4 40.5 47.2 46.8 57.9 60.7 60.2 46.1 56.0 56.5 39.6 60.4 57.6 44.0 46.4 45.8 42.6 68.5 60.5 47.0 62.2 54.4 59.8 48.0 46.0 61.0 45.7 67.8 58.6 47.5 48.9 51.3 68.2 49.2 40.1 34.2 53.9 92.8 68.1 28.9 50.9 88.3 65.3 53.8 51.7 43.4 46.1 57.1 78.5 41.1 44.9 57.3 52.5 50.1 63.0 50.9 33.0 48.8 26.6 64.8 38.5 60.9 71.7 62.4 72.3 51.3 56.3 63.7 46.3 57.5 67.9 56.0 91.2 41.0 30.9 27.6 69.5 60.3 36.2 28.8 54.4 45.2 61.2 41.3 35.4 35.5 71.1 46.7 53.9 60.1 71.9 50.3 46.5 36.3 37.3 55.1 71.6 50.4 89.8 52.9 39.7 82.3 41.3 22.7 36.0 17.8 24.7 19.9 20.4 18.5 23.6 24.3 16.7 15.1 14.3 21.0 19.3 26.3 13.9 20.0 23.9 57.3 61.4 64.4 63.2 59.2 62.3 57.9 60.7 60.4 54.4 61.0 68.2 16.8 16.0 24.3 19.2 26.4 22.3 18.2 17.7 28.5 33.5 24.3 24.6 7.0 21.5 17.7 12.9 20.9 30.1 16.0 28.7 19.6 20.9 12.2 21.5 19.9 19.3 18.5 26.9 17.8 24.9 20.5 25.9 23.0 24.6 19.0 30.0 15.4 12.4 29.2 35.3 19.0 16.4 10.2 20.1 20.5 15.5 23.3 21.3 14.2 15.9 29.3 23.1 21.6 18.1 25.8 23.5 17.3 24.8 24.4 17.7 25.7 15.2 17.1 28.4 13.1 24.2 23.2 28.9 25.1 24.8 31.1 48.7 23.8 44.7 20.2 28.1 PIAS4 "FLJ12419, Piasg, PIASY, ZMIZ6" ENSG00000105229 "Protein inhibitor of activated STAT 4" Q8N2W9 19 4007736-4039386 "Enzymes, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway, Wnt signaling pathway" "DNA-binding, Repressor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 103.7;Late spermatids: 264.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA010598, HPA076008" Enhanced Supported Nucleoplasm,Centrosome NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 78: Testis - Spermatogenesis" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 31: Spermatids - Spermatogenesis" Nucleoplasm Centrosome "HPA010598: AB_1079616, HPA076008: " "unprognostic (1.23e-1)" "unprognostic (8.94e-3)" "unprognostic (3.50e-2)" "prognostic favorable (1.18e-5)" "unprognostic (2.45e-1)" "unprognostic (4.77e-3)" "unprognostic (4.01e-3)" "unprognostic (9.79e-2)" "unprognostic (6.89e-2)" "unprognostic (6.22e-2)" "prognostic favorable (7.04e-4)" "unprognostic (1.33e-2)" "unprognostic (5.98e-2)" "unprognostic (4.52e-3)" "unprognostic (5.76e-2)" "unprognostic (1.25e-1)" "unprognostic (4.67e-3)" 8.0 10.7 9.2 6.0 11.8 4.7 9.0 11.6 11.4 11.0 3.8 15.4 6.6 10.5 2.3 11.1 8.8 2.9 10.1 8.5 7.4 8.7 15.5 7.9 5.6 12.2 11.5 10.6 13.9 3.5 10.4 5.3 10.3 11.4 2.4 3.7 9.8 3.9 10.6 12.7 9.9 3.8 8.5 11.6 12.1 37.2 10.4 5.9 7.5 4.8 4.0 10.4 9.7 17.4 15.1 10.6 9.7 9.3 4.7 4.2 15.4 9.0 4.9 9.2 8.4 16.7 6.8 11.4 7.9 4.8 10.1 15.5 10.0 7.1 4.0 18.5 15.8 8.2 7.8 13.1 9.6 12.0 13.8 4.9 7.8 8.3 5.1 5.1 11.1 11.6 15.5 15.2 4.5 15.5 21.9 13.9 21.6 7.3 9.7 19.3 9.9 15.0 6.1 8.3 17.8 19.8 12.8 12.4 10.3 7.3 11.5 11.0 8.2 9.2 13.2 19.4 14.2 28.3 22.8 14.4 7.7 14.6 11.5 10.5 13.2 19.8 15.2 15.3 10.8 16.1 10.8 14.0 11.0 14.6 9.3 10.6 15.8 17.1 19.5 11.0 13.0 10.3 9.2 11.8 11.6 11.4 8.5 7.4 12.2 11.5 10.3 8.5 10.4 17.4 12.8 3.2 15.0 15.0 10.1 18.4 8.4 15.8 7.4 18.8 14.5 11.2 3.6 11.5 11.5 9.2 12.5 24.3 12.3 13.2 7.9 17.1 103.7 13.9 10.7 12.3 22.1 9.9 7.3 17.6 16.9 9.1 11.7 12.4 7.0 15.2 11.4 12.3 14.6 26.9 5.7 15.6 20.3 8.3 9.2 264.3 14.0 10.6 7.2 2.8 12.8 11.3 10.3 6.6 18.0 13.5 7.8 18.4 12.0 11.9 14.0 12.5 15.6 23.1 6.6 8.1 9.3 69.1 42.1 7.4 15.5 36.4 10.1 13.3 12.4 9.0 PIGA GPI3 ENSG00000165195 "Phosphatidylinositol glycan anchor biosynthesis class A" P37287 X 15319452-15335554 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "GPI-anchor biosynthesis" "Glycosyltransferase, Transferase" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 83.5;Suprabasal keratinocytes: 55.0;Urothelial cells: 62.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 22.9" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001174 Approved NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 41: Macrophages - Immune response" "HPA001174: AB_2666220" "unprognostic (1.15e-1)" "unprognostic (1.04e-1)" "unprognostic (5.90e-2)" "unprognostic (7.92e-2)" "unprognostic (2.05e-1)" "unprognostic (2.16e-1)" "unprognostic (2.99e-3)" "unprognostic (2.24e-2)" "unprognostic (7.37e-3)" "unprognostic (3.93e-3)" "prognostic unfavorable (7.64e-4)" "unprognostic (1.85e-3)" "unprognostic (5.97e-3)" "unprognostic (2.24e-1)" "unprognostic (3.94e-1)" "unprognostic (2.12e-2)" "unprognostic (1.18e-2)" 2.1 2.9 2.2 2.9 2.7 9.2 3.1 2.0 3.6 2.8 0.8 3.7 1.9 3.0 3.5 5.1 2.8 3.7 2.0 1.6 1.8 3.8 4.5 6.7 3.5 2.8 2.7 2.4 4.0 3.3 0.6 3.6 2.2 2.7 3.7 4.5 4.6 1.7 1.3 1.4 2.4 2.5 2.2 2.0 2.8 2.6 2.3 4.0 4.4 1.3 4.7 10.3 1.9 5.8 14.5 8.3 9.1 5.0 2.6 2.8 7.0 3.7 5.7 7.4 7.3 9.2 6.5 6.6 2.9 2.9 9.0 5.8 14.3 11.4 12.6 6.1 9.5 5.5 11.0 5.8 4.5 8.8 2.9 3.3 8.1 10.0 16.0 2.4 5.0 5.2 6.4 7.0 5.1 9.2 9.0 3.4 4.7 5.5 8.2 3.0 12.4 10.7 5.6 9.4 6.2 9.4 6.9 6.8 14.4 8.7 6.6 7.4 4.2 6.2 2.4 14.0 7.3 5.4 7.2 9.9 9.4 5.6 7.9 22.9 3.8 4.3 2.6 6.3 3.7 3.0 4.1 2.6 3.9 2.1 3.8 2.9 5.2 1.8 8.6 2.6 4.1 2.7 2.2 2.7 2.0 3.6 1.6 1.8 2.8 2.7 2.2 2.2 2.3 5.8 6.4 19.2 83.5 6.8 7.2 29.6 41.9 10.6 13.6 3.5 13.2 10.5 6.9 5.7 20.1 3.7 0.0 6.3 7.4 8.4 11.7 7.6 5.4 30.8 9.8 7.9 10.7 9.3 2.2 5.8 10.2 12.7 17.9 45.6 33.6 3.0 3.6 4.4 8.8 3.3 2.0 5.0 2.0 8.4 43.4 4.4 3.1 18.1 28.4 2.8 3.6 4.2 4.1 1.0 7.7 8.3 5.1 3.0 5.5 32.0 2.1 6.6 19.8 3.0 13.1 10.6 16.3 2.7 3.7 35.5 55.0 28.0 11.7 2.9 6.0 62.2 PIK3C2A PI3K-C2alpha ENSG00000011405 "Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha" O00443 11 17077730-17207983 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Endocytosis, Exocytosis" "Kinase, Transferase" "Cataract, Disease variant, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 217.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037641, HPA037642" Uncertain Supported Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 43: Cardiomyocytes - Nuclear processes" Nucleoplasm "Vesicles, Cytosol" "HPA037641: AB_10671878, HPA037642: AB_10697081" "unprognostic (2.35e-1)" "unprognostic (2.16e-2)" "unprognostic (3.71e-2)" "unprognostic (1.06e-1)" "unprognostic (1.63e-1)" "unprognostic (6.63e-2)" "unprognostic (2.47e-2)" "unprognostic (1.39e-1)" "unprognostic (2.29e-2)" "unprognostic (1.86e-2)" "unprognostic (4.74e-2)" "unprognostic (1.84e-1)" "prognostic favorable (1.66e-4)" "unprognostic (3.20e-2)" "unprognostic (1.51e-1)" "unprognostic (1.18e-1)" "unprognostic (1.37e-1)" 22.5 13.7 16.3 12.3 25.9 9.4 15.9 22.5 14.6 16.1 17.4 13.2 14.9 18.0 15.7 15.4 14.5 19.0 12.4 10.5 14.0 23.5 15.5 16.6 11.3 16.6 16.1 14.1 12.3 43.6 10.3 23.1 17.0 16.4 13.0 22.4 11.8 14.8 6.4 12.3 11.8 18.3 13.8 13.0 18.0 19.3 19.6 9.4 30.7 12.1 10.9 14.9 12.0 15.8 53.8 24.1 39.6 24.8 28.0 28.3 35.3 33.2 35.7 23.9 33.2 58.9 6.0 15.6 16.2 28.6 39.1 34.8 31.9 25.4 42.1 13.5 27.6 9.8 28.4 23.3 30.6 12.3 14.9 22.2 17.5 23.6 45.8 22.2 57.7 9.9 23.4 14.7 18.6 16.6 6.6 7.7 22.6 30.1 18.5 6.9 41.1 11.0 29.6 47.0 23.2 20.5 50.6 21.4 23.2 33.0 12.7 12.3 72.5 19.1 27.4 50.1 20.4 5.9 14.1 12.8 22.8 11.3 22.6 1.7 1.5 1.1 1.7 1.0 1.1 1.4 1.3 1.3 2.1 1.5 1.7 1.0 2.3 1.8 3.2 1.4 0.9 0.6 16.3 25.9 22.5 14.6 10.5 14.0 16.6 16.1 17.0 13.8 19.6 15.8 93.2 76.9 62.0 217.4 25.0 35.3 26.1 18.7 24.5 49.1 34.7 25.0 29.7 25.8 33.1 36.8 70.9 29.6 29.5 22.6 19.6 19.8 35.9 51.8 35.1 87.6 28.7 11.2 57.0 25.1 17.9 28.6 45.3 72.4 32.2 22.8 106.7 32.4 19.2 35.3 81.1 23.5 18.3 46.3 33.1 18.6 25.7 27.0 19.6 69.3 19.6 73.0 17.5 62.8 79.4 26.1 13.1 31.2 29.9 42.7 15.2 22.4 26.4 40.4 39.5 33.7 35.1 52.6 26.8 23.5 34.0 143.5 25.3 25.1 20.7 37.3 PIK3C2B "C2-PI3K, PI3K-C2beta" ENSG00000133056 "Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta" O00750 1 204422628-204494724 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 44.2" "Cell type enhanced" "Detected in many" "Oligodendrocytes: 111.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "naive B-cell: 3.2" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "BEWO: 70.3;RT4: 75.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030515, HPA050360" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 70: Brain - Nervous system development" "Cluster 28: BEWO - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm Cytosol "HPA030515: AB_10670043, HPA050360: AB_2681104" "unprognostic (5.77e-2)" "unprognostic (1.36e-1)" "unprognostic (1.36e-1)" "unprognostic (2.18e-2)" "unprognostic (3.45e-1)" "unprognostic (2.19e-3)" "prognostic unfavorable (5.42e-4)" "unprognostic (3.35e-3)" "unprognostic (3.57e-3)" "unprognostic (2.72e-2)" "unprognostic (8.54e-2)" "unprognostic (1.10e-1)" "unprognostic (2.54e-1)" "unprognostic (5.36e-2)" "unprognostic (1.26e-1)" "unprognostic (1.75e-1)" "prognostic favorable (1.16e-4)" 12.0 3.6 10.4 15.2 23.6 5.0 9.7 8.5 23.3 7.4 0.0 15.8 14.4 8.4 4.8 12.9 6.5 8.0 10.6 11.2 18.8 10.2 4.9 17.2 23.4 19.2 20.4 3.0 5.2 3.2 3.3 12.8 17.1 6.2 12.9 2.9 7.2 5.4 20.9 21.2 14.9 9.9 7.3 13.6 18.9 1.9 28.0 22.3 8.1 10.8 22.1 10.9 10.7 44.2 7.5 14.8 12.9 11.9 7.4 0.6 70.3 0.9 2.9 2.8 2.1 8.8 19.2 12.7 2.7 1.7 2.5 18.3 7.7 5.2 1.1 7.7 2.1 0.3 30.1 3.3 0.4 4.5 9.3 0.9 5.4 0.7 0.4 1.1 19.1 12.6 4.7 8.3 0.2 16.7 15.4 12.8 11.8 29.3 9.3 16.6 3.3 2.4 3.5 75.6 14.1 7.8 26.0 35.9 8.4 4.7 16.1 2.4 0.7 0.4 4.5 1.3 0.2 8.9 2.6 16.4 0.5 6.7 1.9 0.0 0.1 0.0 0.5 0.0 0.5 1.5 0.6 0.4 0.1 3.2 0.3 0.3 0.2 0.8 0.0 0.0 1.2 0.2 10.4 23.6 8.5 23.3 11.2 18.8 19.2 20.4 17.1 7.3 28.0 44.2 26.7 0.0 12.2 16.0 15.3 3.8 2.1 7.9 1.2 16.6 5.3 4.4 6.9 5.7 6.9 3.7 0.0 4.4 3.3 29.2 0.0 1.8 0.6 2.0 2.5 26.1 9.6 0.0 14.3 3.4 4.4 4.5 28.5 2.4 32.4 8.5 31.1 5.5 4.2 15.2 22.8 23.8 2.0 1.6 5.1 0.7 1.2 2.9 3.6 27.2 2.3 2.7 4.1 23.6 111.5 4.7 14.5 7.5 4.9 2.4 14.6 2.1 9.1 1.0 0.0 7.7 3.3 0.1 1.5 8.1 8.0 2.2 5.0 9.4 15.5 13.8 PIK3C2G ENSG00000139144 "Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 gamma" O75747 12 18242961-18648416 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Chemotaxis "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "epididymis: 16.7;stomach 1: 21.7" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 44.9;Breast glandular cells: 30.4;Breast myoepithelial cells: 37.6;Collecting duct cells: 40.5;Gastric mucus-secreting cells: 140.6" "Cancer enhanced" "Detected in some" "stomach cancer: 2.6" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "BEWO: 1.2;HaCaT: 2.1;hTERT-HME1: 3.4" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 29: Non-specific - Vesicular transport" "Cluster 30: Epithelial cell lines - Translation" "Cluster 16: Pancreatic endocrine cells - Mixed function" "unprognostic (1.29e-1)" "unprognostic (1.61e-1)" "unprognostic (6.21e-2)" "unprognostic (1.47e-2)" "unprognostic (9.46e-2)" "unprognostic (8.27e-2)" "unprognostic (2.85e-1)" "unprognostic (6.52e-2)" "unprognostic (1.81e-3)" "prognostic unfavorable (3.50e-4)" "unprognostic (6.05e-2)" "unprognostic (1.81e-1)" "unprognostic (2.74e-1)" "unprognostic (1.98e-1)" "unprognostic (2.37e-2)" 0.0 0.6 0.4 0.0 0.1 0.1 9.7 0.3 0.4 0.2 0.1 0.1 0.5 0.1 16.7 2.4 1.2 6.3 0.0 0.1 0.7 4.6 12.0 0.3 0.1 0.1 0.2 0.0 1.4 4.8 0.0 0.0 0.1 0.9 0.2 0.1 3.7 9.4 0.0 9.7 3.3 0.0 0.3 0.1 21.7 0.4 0.4 0.1 0.0 0.1 0.1 0.0 0.5 0.3 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 2.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 3.4 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.3 0.4 0.1 0.7 0.1 0.2 0.1 0.3 0.4 0.3 1.1 0.0 0.0 1.3 0.7 17.5 8.5 0.3 44.9 0.0 30.4 37.6 0.3 27.1 0.8 40.5 0.0 1.2 0.4 0.2 1.9 2.0 9.0 4.5 1.5 1.2 0.0 2.7 2.9 0.0 4.8 0.4 140.6 10.1 0.0 0.0 0.7 27.4 0.2 0.0 1.8 2.3 0.0 0.8 1.1 1.8 0.0 0.5 1.8 7.5 0.0 0.0 0.0 1.5 1.4 0.8 5.1 0.0 1.3 0.8 18.4 1.3 0.1 0.0 0.0 0.1 0.5 2.4 3.0 27.3 21.5 0.8 1.0 0.0 3.0 1.6 PIK3C3 Vps34 ENSG00000078142 "Phosphatidylinositol 3-kinase catalytic subunit type 3" Q8NEB9 18 41955234-42087830 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Autophagy, Cell cycle, Cell division" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 114.9;Inhibitory neurons: 104.1;Oligodendrocytes: 115.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040718 Approved NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 34: Non-specific - Transcription" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA040718: AB_10793862" "unprognostic (1.26e-1)" "unprognostic (1.24e-1)" "unprognostic (1.40e-2)" "unprognostic (3.55e-3)" "unprognostic (6.15e-2)" "unprognostic (3.61e-2)" "unprognostic (6.00e-3)" "unprognostic (1.91e-1)" "unprognostic (2.11e-1)" "unprognostic (1.71e-2)" "unprognostic (3.86e-2)" "unprognostic (6.41e-2)" "prognostic favorable (4.97e-4)" "unprognostic (1.09e-1)" "unprognostic (1.35e-2)" "unprognostic (1.76e-1)" "unprognostic (6.85e-3)" 10.9 16.1 6.8 12.0 10.0 15.9 16.4 18.2 11.5 13.2 12.7 11.7 8.9 15.0 16.6 11.8 12.2 12.1 11.5 7.3 7.8 16.2 14.3 11.7 14.1 8.3 7.0 17.0 9.0 18.6 8.0 17.2 9.9 12.8 13.7 16.7 10.9 12.5 12.2 11.4 10.6 13.9 8.7 13.3 11.5 18.0 7.6 18.5 15.3 16.2 15.8 15.1 9.9 12.9 16.2 11.3 27.8 21.3 31.6 33.8 17.1 31.4 39.8 24.7 33.2 5.4 8.0 10.0 17.6 31.8 19.4 26.0 22.1 17.5 34.2 16.3 15.5 20.8 15.4 21.7 26.3 30.9 22.1 37.3 25.8 23.2 29.9 37.9 25.6 19.9 20.9 12.2 34.3 5.3 13.6 19.8 20.4 6.0 8.1 81.9 21.0 26.1 28.3 17.1 24.2 28.1 10.2 7.3 22.2 30.8 10.8 24.8 33.7 33.3 9.7 7.4 14.6 33.3 42.2 11.3 27.5 41.4 18.0 20.5 9.9 21.2 9.2 11.0 10.3 11.4 9.3 11.5 10.2 10.1 11.8 8.9 19.2 12.1 12.5 5.8 17.0 8.2 6.8 10.0 18.2 11.5 7.3 7.8 8.3 7.0 9.9 8.7 7.6 12.9 22.4 22.4 36.9 70.2 21.1 11.5 10.8 15.3 15.4 28.2 11.5 11.0 23.5 4.3 27.3 14.7 20.9 20.6 26.8 13.8 7.9 14.4 28.6 16.9 22.4 19.9 4.9 19.1 114.9 10.3 13.3 22.4 13.7 18.3 17.1 25.4 17.2 13.4 15.6 55.5 104.1 11.5 16.2 17.9 10.1 13.2 14.6 20.9 7.2 58.1 21.5 26.2 13.4 83.4 115.6 14.3 10.0 24.0 18.2 14.5 12.9 12.3 22.4 22.5 19.7 25.4 18.9 20.0 18.6 14.3 11.4 27.4 23.8 24.7 10.6 15.9 PIK3CA PI3K ENSG00000121879 "Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha" P42336 3 179148114-179240093 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Angiogenesis, Lipid metabolism, Phagocytosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "Excitatory neurons: 126.7;Inhibitory neurons: 122.0;Oligodendrocyte precursor cells: 130.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA009985, CAB017804" Approved Supported Mitochondria,Cytosol NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Cytosol Mitochondria "CAB017804: , HPA009985: AB_1079610" "unprognostic (1.81e-1)" "unprognostic (2.77e-1)" "unprognostic (2.18e-1)" "unprognostic (2.69e-3)" "unprognostic (6.49e-3)" "unprognostic (1.43e-1)" "unprognostic (2.65e-2)" "unprognostic (1.00e-2)" "unprognostic (1.03e-1)" "unprognostic (2.37e-1)" "unprognostic (2.57e-3)" "unprognostic (5.21e-2)" "unprognostic (4.50e-2)" "unprognostic (1.16e-2)" "unprognostic (2.48e-1)" "unprognostic (9.74e-2)" "unprognostic (3.82e-2)" 14.7 7.9 3.1 8.1 3.7 12.4 8.5 9.7 8.3 8.7 0.3 6.7 4.2 8.3 4.8 7.9 5.7 8.4 9.5 3.7 3.6 8.2 7.1 7.9 9.2 5.1 4.2 10.3 4.3 11.5 3.4 11.1 5.1 7.3 5.8 12.4 4.5 7.1 7.1 5.5 5.3 8.9 2.3 8.8 5.8 6.1 3.7 13.7 7.9 13.0 9.2 8.6 5.8 6.4 19.9 6.5 9.6 9.2 22.7 27.7 6.5 10.8 16.5 10.9 16.0 5.1 13.0 16.1 21.7 10.8 14.1 5.9 8.4 9.8 16.5 32.0 6.2 22.4 5.2 4.4 10.7 13.1 12.6 16.8 10.6 12.4 15.0 13.4 15.8 12.9 10.6 17.3 18.9 6.9 10.9 8.5 8.0 8.8 7.8 13.9 10.0 16.7 8.5 10.0 5.2 9.9 13.1 10.8 16.1 9.1 19.0 11.1 21.1 10.4 6.5 18.1 13.3 9.3 13.8 29.0 11.3 9.6 5.4 1.3 1.2 0.4 1.2 1.0 0.8 1.5 0.8 0.6 0.8 1.6 1.0 0.8 2.2 0.7 0.9 0.9 0.8 0.3 3.1 3.7 9.7 8.3 3.7 3.6 5.1 4.2 5.1 2.3 3.7 6.4 31.3 32.1 26.8 60.7 28.3 14.7 17.9 11.2 2.2 27.9 14.4 15.2 18.5 5.7 15.9 7.3 31.3 10.2 17.9 8.7 1.9 10.7 2.0 14.1 21.7 25.6 2.4 9.2 126.7 13.9 6.1 23.5 8.6 21.6 31.6 19.9 33.5 21.9 11.1 38.7 122.0 10.3 14.2 23.5 24.3 3.4 32.6 20.9 14.2 75.9 24.5 17.4 18.6 130.2 84.2 16.9 10.8 39.5 15.1 34.6 9.5 14.8 20.1 27.1 26.3 25.7 28.6 11.8 10.2 9.8 14.9 8.8 19.9 19.6 9.2 32.0 PIK3CB PIK3C1 ENSG00000051382 "Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta" P42338 3 138652698-138834928 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins" "Autophagy, Cell adhesion, Endocytosis" "Kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 96.5;Inhibitory neurons: 92.4;Oligodendrocytes: 88.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "HEL: 115.2;HMC-1: 185.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB031938, HPA042288, HPA064207" Approved Supported Nucleoplasm,Nucleoli,Vesicles,Midbody Yes No "Cluster 52: Eosinophils - Transcription" "Cluster 7: Kidney - Transmembrane transport" "Cluster 3: HMC-1 - Innate immune response" "Cluster 38: Extravillous trophoblasts - Unknown function" Nucleoplasm "Nucleoli, Vesicles, Midbody" "CAB031938: AB_2165408, HPA042288: , HPA064207: AB_2685212" "unprognostic (4.89e-2)" "unprognostic (1.42e-2)" "unprognostic (5.97e-2)" "unprognostic (7.85e-2)" "unprognostic (4.89e-2)" "unprognostic (6.01e-2)" "prognostic unfavorable (6.42e-4)" "unprognostic (3.98e-2)" "unprognostic (1.35e-1)" "unprognostic (2.28e-1)" "prognostic unfavorable (3.99e-5)" "unprognostic (2.15e-1)" "unprognostic (6.18e-3)" "unprognostic (9.33e-2)" "unprognostic (7.82e-2)" "unprognostic (2.79e-1)" "unprognostic (4.59e-2)" 11.6 7.4 4.3 12.4 5.0 23.7 11.9 8.6 8.6 12.4 14.4 17.8 17.8 8.2 7.0 18.0 12.1 10.3 15.8 5.4 4.4 26.4 11.0 11.2 12.3 5.1 3.3 9.2 22.3 19.3 2.7 18.6 6.1 15.0 18.1 23.0 19.8 12.0 19.5 23.7 17.9 9.1 3.5 10.8 13.0 8.0 4.0 17.0 43.2 13.2 13.2 9.9 5.4 7.9 64.1 21.9 11.7 9.4 10.6 13.0 79.2 14.2 14.5 15.1 16.7 26.0 25.2 25.0 38.0 13.7 29.1 27.5 15.1 24.1 27.3 31.8 12.5 115.2 14.8 17.3 11.8 30.1 185.1 12.4 17.6 10.2 21.9 26.4 21.5 12.3 43.0 19.0 18.1 28.6 17.8 20.7 16.6 49.2 19.5 11.5 12.2 19.6 24.5 35.5 9.8 7.4 37.6 18.0 56.2 34.7 44.8 73.0 20.3 8.4 11.7 21.2 21.1 30.3 22.1 23.7 22.8 27.7 14.0 4.4 5.1 6.9 2.4 2.8 1.6 2.8 2.8 1.8 5.9 2.6 3.5 2.4 6.4 0.8 2.8 1.0 1.5 2.0 4.3 5.0 8.6 8.6 5.4 4.4 5.1 3.3 6.1 3.5 4.0 7.9 19.7 9.6 21.3 40.1 12.1 19.1 18.7 12.5 14.2 16.2 13.1 7.7 37.3 12.8 18.3 18.4 25.0 35.5 6.9 30.3 5.9 11.1 1.1 18.3 4.0 13.9 16.3 8.0 96.5 19.4 61.1 7.3 21.4 18.8 14.5 6.7 9.7 19.1 14.4 21.9 92.4 17.1 4.1 33.3 23.1 1.7 3.7 28.1 7.2 37.5 29.5 8.9 11.3 48.2 88.2 20.0 25.9 6.8 10.2 25.8 21.9 23.4 17.4 19.5 6.6 8.6 5.9 16.0 19.9 22.1 23.3 47.9 11.6 4.2 15.1 17.5 PIK3CD p110D ENSG00000171608 "Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta" O00329 1 9651731-9729114 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Adaptive immunity, Chemotaxis, Differentiation, Immunity, Inflammatory response, Innate immunity" "Kinase, Transferase" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 60.9;lymphoid tissue: 50.4" "Cell type enhanced" "Detected in many" "dendritic cells: 44.0;granulocytes: 25.3;Kupffer cells: 35.2;Microglial cells: 29.0;NK-cells: 29.9;T-cells: 37.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HDLM-2: 153.3;NB-4: 65.9;REH: 68.9;THP-1: 65.4;U-937: 78.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB015420, HPA044953" Enhanced Approved "Vesicles,Cytokinetic bridge" Yes No "Cluster 8: Neutrophils - Inflammatory response" "Cluster 2: Immune cells - Immune response" "Cluster 43: THP-1 - Innate immune response" "Cluster 63: NK-cells & T-cells - Immune response" Vesicles "Cytokinetic bridge" "CAB015420: AB_831654, HPA044953: AB_2679153" "unprognostic (5.73e-3)" "unprognostic (2.75e-3)" "unprognostic (8.93e-2)" "unprognostic (4.05e-2)" "unprognostic (4.71e-2)" "unprognostic (1.40e-2)" "unprognostic (2.13e-1)" "unprognostic (7.42e-2)" "unprognostic (2.78e-2)" "unprognostic (1.54e-2)" "unprognostic (3.46e-2)" "unprognostic (6.75e-2)" "unprognostic (8.65e-3)" "unprognostic (2.09e-1)" "unprognostic (1.34e-1)" "unprognostic (2.04e-1)" "unprognostic (6.78e-2)" 7.2 3.1 6.8 33.4 6.3 60.9 3.9 6.1 7.5 6.2 6.4 5.4 5.2 4.9 1.7 4.9 6.1 7.0 3.3 7.0 5.3 6.4 3.5 12.0 46.9 7.3 6.6 7.0 3.0 2.9 2.8 4.2 7.8 4.6 3.4 0.6 5.1 2.7 1.2 3.0 17.2 4.7 6.6 50.4 5.7 4.0 9.3 24.3 5.5 3.5 32.0 7.4 5.1 8.5 8.1 5.2 0.4 1.4 1.3 1.1 0.7 12.1 24.5 26.0 21.1 0.3 3.3 21.5 4.9 9.8 12.4 2.4 2.0 11.0 16.2 153.3 0.4 2.4 1.3 9.0 5.1 56.0 18.7 4.3 4.5 29.2 9.8 11.4 3.8 14.9 8.0 0.1 15.0 0.6 5.4 65.9 2.2 0.3 1.4 68.9 13.0 0.7 10.9 0.0 1.7 1.5 2.7 4.9 11.9 6.8 0.8 65.4 9.8 7.7 7.9 0.2 11.5 4.9 4.9 30.1 16.7 78.6 4.4 18.0 23.5 40.2 21.6 23.0 22.6 12.8 16.3 19.9 22.5 13.6 20.9 23.1 63.2 25.9 29.2 25.7 13.3 38.3 6.8 6.3 6.1 7.5 7.0 5.3 7.3 6.6 7.8 6.6 9.3 8.5 1.7 9.6 13.4 2.0 22.2 1.5 2.2 1.8 4.0 0.7 2.0 1.7 3.1 0.0 1.1 0.0 2.1 0.3 44.0 0.1 1.9 3.9 3.0 2.0 1.7 2.7 0.0 10.3 6.7 2.0 0.5 2.9 0.0 1.0 25.3 4.2 3.6 0.0 14.7 0.0 13.4 0.1 0.0 35.2 6.0 2.8 1.2 23.1 3.6 29.0 19.3 2.5 29.9 1.0 1.1 11.3 0.0 1.5 8.2 4.1 0.2 3.8 3.3 1.3 6.6 2.0 4.7 1.5 3.4 2.9 1.1 0.3 37.1 1.5 0.2 2.1 PIK3CG ENSG00000105851 "Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma" P48736 7 106865278-106908980 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "Angiogenesis, Chemotaxis, Endocytosis, Immunity, Inflammatory response" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "bone marrow: 43.6;lymphoid tissue: 19.7" "Cell type enhanced" "Detected in some" "B-cells: 24.9;dendritic cells: 26.5;Early spermatids: 28.9;granulocytes: 20.8;monocytes: 23.8;NK-cells: 25.7;Plasma cells: 88.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in some" "Daudi: 29.4;HL-60: 28.8;HMC-1: 34.9;Karpas-707: 29.1;MOLT-4: 56.0;U-266/70: 71.4;U-937: 52.1" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA069976 Enhanced Supported "Plasma membrane,Cytosol" NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 29: U-266 - Adaptive immune response" "Cluster 55: Plasma cells - Humoral immune response" "Plasma membrane" Cytosol "HPA069976: AB_2686224" "unprognostic (8.34e-2)" "unprognostic (2.01e-2)" "unprognostic (1.44e-2)" "unprognostic (1.71e-2)" "unprognostic (3.20e-2)" "unprognostic (3.82e-3)" "unprognostic (3.02e-1)" "unprognostic (6.77e-2)" "unprognostic (1.16e-1)" "unprognostic (7.06e-3)" "unprognostic (1.15e-1)" "unprognostic (1.97e-1)" "unprognostic (1.77e-2)" "unprognostic (9.08e-2)" "unprognostic (1.23e-1)" "unprognostic (5.38e-1)" "unprognostic (5.24e-2)" 3.1 1.8 0.5 11.5 0.6 43.6 1.9 0.8 1.3 1.9 1.3 4.2 4.1 1.3 0.5 1.7 1.4 3.2 1.6 0.5 1.0 1.0 2.0 4.9 19.0 2.5 1.3 1.6 0.3 0.7 0.2 2.9 2.7 1.0 3.8 0.1 1.3 0.9 0.3 0.8 4.3 2.7 1.8 11.0 4.0 5.2 2.0 16.4 1.1 1.0 19.7 4.3 0.2 3.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 29.4 2.7 0.0 0.1 0.1 0.0 0.0 0.0 0.3 0.0 17.9 0.0 0.0 0.0 28.8 34.9 0.0 0.0 0.0 0.0 0.0 11.0 16.9 20.6 29.1 0.0 0.0 56.0 17.6 0.0 0.0 0.0 14.6 0.0 19.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 20.6 2.9 0.1 0.2 0.1 0.0 71.4 0.0 27.3 0.1 52.1 6.7 10.8 6.0 24.3 8.8 17.8 8.1 7.3 4.1 6.7 9.4 10.2 4.2 5.9 22.7 9.8 43.7 8.6 4.4 6.8 0.5 0.6 0.8 1.3 0.5 1.0 2.5 1.3 2.7 1.8 2.0 3.9 1.5 0.0 1.8 0.3 24.9 0.8 0.0 0.0 0.6 0.0 0.1 0.1 0.5 0.0 0.6 0.0 0.0 0.0 26.5 0.2 0.0 0.0 28.9 0.1 0.2 1.7 0.0 7.8 5.5 0.0 0.0 0.1 3.6 0.1 20.8 0.4 2.5 0.5 6.8 0.0 0.3 0.0 0.0 11.9 8.3 18.8 0.6 18.9 7.2 15.0 23.8 0.0 25.7 0.0 0.2 0.0 0.0 0.0 88.4 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.2 6.6 3.7 0.2 0.3 0.1 18.1 0.6 0.6 0.1 PIK3R4 "p150, VPS15" ENSG00000196455 "Phosphoinositide-3-kinase regulatory subunit 4" Q99570 3 130678934-130746829 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036032, HPA036033" Approved Approved Vesicles,Microtubules NA NA "Cluster 46: Basophils - DNA binding" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 59: Non-specific - Transcription" Vesicles Microtubules "HPA036032: AB_10610281, HPA036033: AB_2674911" "unprognostic (7.50e-2)" "unprognostic (3.90e-3)" "unprognostic (1.68e-1)" "unprognostic (4.05e-3)" "unprognostic (2.88e-1)" "unprognostic (1.28e-1)" "unprognostic (1.34e-1)" "unprognostic (1.21e-1)" "unprognostic (1.11e-1)" "unprognostic (2.67e-1)" "unprognostic (1.02e-3)" "unprognostic (7.26e-2)" "prognostic favorable (4.40e-6)" "unprognostic (8.25e-2)" "unprognostic (3.72e-1)" "unprognostic (2.27e-1)" "unprognostic (1.05e-1)" 8.8 8.5 3.7 7.8 4.2 8.9 10.0 5.2 4.9 9.4 5.6 8.2 7.5 10.1 7.9 8.0 9.1 7.2 7.6 4.1 4.5 10.5 21.2 9.6 9.4 3.2 3.6 12.4 6.9 17.6 6.1 9.7 3.8 9.8 8.1 16.5 7.6 9.6 7.3 7.8 8.0 10.4 3.8 10.0 7.5 11.4 3.2 11.4 13.1 8.6 10.4 9.0 6.5 7.1 20.7 12.9 18.5 13.4 26.6 21.1 12.8 15.0 17.9 20.2 23.3 16.7 17.1 24.2 18.4 15.2 16.1 28.7 30.7 23.3 31.6 14.7 11.3 19.7 13.8 11.7 12.2 30.3 9.5 14.7 16.4 21.7 13.6 12.6 19.0 13.8 23.3 11.9 18.1 18.1 24.9 9.2 23.3 18.6 12.4 17.2 21.4 21.9 13.2 16.7 17.0 12.4 21.6 13.4 15.3 21.5 18.6 13.1 15.2 15.5 13.3 17.6 12.2 13.8 13.5 31.2 17.0 11.3 14.7 9.7 5.3 7.0 6.3 6.0 9.3 5.6 5.7 4.7 6.9 3.5 6.6 6.0 4.4 8.5 6.6 2.4 6.8 5.3 3.7 4.2 5.2 4.9 4.1 4.5 3.2 3.6 3.8 3.8 3.2 7.1 8.3 6.4 8.7 18.6 8.8 3.8 3.9 5.7 10.8 8.1 5.7 4.7 7.7 8.6 9.6 11.0 14.6 5.6 7.2 5.5 1.9 5.0 4.4 8.9 7.5 8.9 3.0 9.2 28.5 5.8 3.4 6.9 13.3 9.9 9.5 9.5 7.5 18.2 5.9 5.0 30.3 6.8 8.2 6.4 2.6 3.1 9.6 7.3 5.4 20.6 7.1 9.0 6.2 22.1 32.9 6.6 4.3 11.7 6.9 4.8 6.2 4.2 12.6 12.6 6.6 8.9 6.2 17.0 13.9 9.5 4.4 4.2 7.5 9.6 6.1 3.4 PIKFYVE "FAB1, KIAA0981, MGC40423, p235, PIP5K, PIP5K3, ZFYVE29" ENSG00000115020 "Phosphoinositide kinase, FYVE-type zinc finger containing" Q9Y2I7 2 208266255-208358746 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Transferase" "Corneal dystrophy, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "B-cells: 82.0;Oligodendrocyte precursor cells: 80.9;Oligodendrocytes: 81.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA042604 Uncertain NA NA "Cluster 19: B-cells - Humoral immune response" "Cluster 34: Non-specific - Transcription" "Cluster 32: U-937 - Innate immune response" "Cluster 57: B-cells - Immune response" "HPA042604: AB_10796580" "unprognostic (1.00e-1)" "unprognostic (1.67e-1)" "unprognostic (1.88e-1)" "unprognostic (3.03e-1)" "unprognostic (2.04e-2)" "prognostic favorable (6.81e-4)" "unprognostic (6.82e-3)" "unprognostic (6.45e-2)" "unprognostic (1.85e-2)" "unprognostic (3.81e-2)" "unprognostic (1.77e-1)" "unprognostic (2.10e-2)" "unprognostic (1.32e-1)" "unprognostic (2.14e-1)" "unprognostic (3.29e-1)" "unprognostic (1.06e-1)" "unprognostic (7.05e-2)" 10.4 7.9 7.6 12.0 7.6 28.8 8.1 14.3 9.3 9.1 10.5 6.1 6.0 9.3 11.9 6.3 6.4 7.2 7.4 7.7 7.3 10.6 10.5 7.8 17.4 8.0 7.4 10.0 22.2 11.1 6.0 9.7 6.9 11.5 7.4 17.3 6.5 8.0 6.5 8.2 7.3 8.9 7.4 15.1 8.0 14.0 8.9 19.3 12.2 9.0 16.1 8.2 5.8 11.1 8.0 7.9 18.3 14.3 18.1 21.4 8.5 9.6 19.5 11.1 15.0 11.3 6.6 9.2 9.8 16.6 21.7 8.0 16.1 10.8 18.8 7.9 10.1 33.0 15.6 10.2 13.7 29.5 28.5 16.0 11.5 13.0 24.1 18.5 18.3 24.1 22.7 16.1 14.0 3.4 26.9 22.1 15.2 6.1 5.9 9.9 14.2 12.7 14.2 11.5 5.8 13.8 10.6 6.8 19.2 21.4 4.3 31.3 21.2 13.8 9.2 9.4 9.0 11.2 14.2 19.2 11.1 25.2 13.9 0.9 0.5 0.4 0.9 0.4 0.5 4.4 1.2 1.4 0.5 3.2 0.9 1.1 0.7 3.2 0.7 1.2 0.9 0.3 7.6 7.6 14.3 9.3 7.7 7.3 8.0 7.4 6.9 7.4 8.9 11.1 18.8 25.6 16.2 58.8 82.0 15.3 6.7 7.8 25.6 21.9 10.5 6.6 17.5 11.5 10.6 11.0 16.7 8.1 14.4 8.1 5.9 5.4 10.4 11.3 19.4 18.8 18.6 25.5 72.6 4.3 5.7 15.7 16.3 21.7 36.1 18.0 18.2 19.4 14.4 10.1 67.9 9.6 4.1 29.9 32.5 8.3 18.6 28.5 10.6 48.7 19.1 13.5 16.5 80.9 81.7 8.5 5.9 13.5 10.3 18.1 14.3 9.9 9.2 19.7 13.1 15.4 18.9 30.5 23.0 14.8 15.3 7.3 21.5 13.3 8.8 11.4 PIM1 PIM ENSG00000137193 "Pim-1 proto-oncogene, serine/threonine kinase" P11309 6 37170152-37175428 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 219.0" "Cell type enhanced" "Detected in many" "Erythroid cells: 368.2;Suprabasal keratinocytes: 228.6;Urothelial cells: 455.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 321.3" "Lineage enriched" "Detected in all" 4 "granulocytes: 321.3" "Cell line enhanced" "Detected in all" "HEL: 219.9;HMC-1: 391.5;K-562: 192.7;U-698: 735.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003941, CAB017040" Uncertain Supported Nucleoplasm,Nucleoli,Cytosol NA NA "Cluster 46: Basophils - DNA binding" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 55: Plasma cells - Humoral immune response" Cytosol "Nucleoplasm, Nucleoli" "CAB017040: , HPA003941: AB_1079618" "unprognostic (1.25e-2)" "unprognostic (4.77e-1)" "unprognostic (3.61e-2)" "prognostic unfavorable (9.73e-4)" "unprognostic (1.91e-2)" "unprognostic (1.06e-1)" "unprognostic (3.75e-1)" "unprognostic (4.64e-2)" "unprognostic (2.36e-1)" "unprognostic (1.10e-1)" "unprognostic (2.65e-2)" "unprognostic (7.32e-2)" "unprognostic (2.14e-3)" "unprognostic (8.16e-3)" "unprognostic (1.04e-1)" "unprognostic (5.26e-3)" "unprognostic (2.90e-1)" 152.8 14.4 8.5 42.3 8.6 219.0 46.2 10.5 10.7 82.9 10.0 45.8 39.2 46.3 2.6 201.5 66.4 52.6 65.4 7.9 11.6 27.0 58.0 49.8 38.5 15.1 12.2 60.4 20.4 3.4 14.8 28.9 12.8 22.5 17.8 8.2 41.1 7.5 36.3 109.8 44.4 38.1 12.3 61.7 40.3 10.7 11.6 26.6 22.7 5.8 26.8 101.6 113.3 12.1 19.1 7.9 12.1 6.7 27.2 14.5 141.9 6.7 20.3 13.5 21.5 28.3 26.2 38.3 10.4 8.0 30.2 21.7 12.7 20.1 12.3 174.4 8.4 219.9 8.7 37.0 27.9 3.8 391.5 49.0 24.5 12.4 8.3 14.9 4.0 9.2 192.7 59.7 2.2 5.0 12.3 19.9 22.7 35.4 12.1 29.7 22.0 45.7 3.9 114.4 58.8 11.9 14.7 1.7 3.8 27.9 3.2 6.5 7.4 7.8 23.3 35.6 8.5 28.0 15.9 735.7 3.4 55.3 8.1 321.3 8.0 113.5 60.3 7.3 77.7 7.1 53.4 53.8 6.3 5.2 47.1 36.9 61.7 39.8 4.2 1.9 41.3 42.1 8.5 8.6 10.5 10.7 7.9 11.6 15.1 12.2 12.8 12.3 11.6 12.1 41.1 22.4 16.0 2.9 35.1 127.8 166.5 63.3 26.7 4.9 9.6 5.3 36.0 18.6 37.6 9.2 0.0 36.5 55.0 50.4 5.9 40.6 4.8 40.3 125.8 33.3 37.1 368.2 2.4 17.2 121.8 67.4 26.0 92.0 49.3 27.5 11.0 33.8 53.6 15.2 2.2 12.4 44.7 44.3 47.4 12.4 8.1 53.9 44.4 4.7 72.3 7.6 112.3 1.0 0.9 60.7 34.2 3.0 190.1 109.6 51.1 17.2 12.9 1.7 0.0 34.2 41.3 14.5 33.9 92.8 228.6 80.7 118.0 1.1 7.8 455.2 PIM2 ENSG00000102096 "Pim-2 proto-oncogene, serine/threonine kinase" Q9P1W9 X 48913182-48919024 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 102.3;intestine: 87.6;lymphoid tissue: 163.9" "Cell type enriched" "Detected in many" 4 "Plasma cells: 738.8" "Cancer enriched" "Detected in all" 6 "testis cancer: 171.3" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Group enriched" "Detected in all" 5 "HDLM-2: 567.6;Karpas-707: 675.0;RPMI-8226: 703.9;U-266/70: 1218.7;U-266/84: 1160.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000285 Approved Cytosol NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 16: Immune cells - Immune response" "Cluster 29: U-266 - Adaptive immune response" "Cluster 55: Plasma cells - Humoral immune response" Cytosol "HPA000285: AB_1079619" "unprognostic (2.34e-3)" "prognostic favorable (4.05e-5)" "unprognostic (8.04e-2)" "unprognostic (7.30e-2)" "unprognostic (6.41e-3)" "unprognostic (2.74e-3)" "unprognostic (2.84e-1)" "unprognostic (5.23e-2)" "unprognostic (2.47e-2)" "unprognostic (4.01e-2)" "unprognostic (1.33e-3)" "unprognostic (2.73e-1)" "prognostic unfavorable (1.17e-11)" "unprognostic (3.36e-2)" "unprognostic (1.96e-2)" "unprognostic (1.27e-1)" "unprognostic (4.38e-2)" 7.9 7.1 10.9 85.4 11.4 102.3 8.8 9.6 12.3 6.1 11.1 40.8 87.6 5.1 10.1 8.2 11.9 16.7 5.2 15.4 12.4 9.8 10.4 23.5 114.3 9.7 10.7 10.3 4.7 3.8 10.1 4.9 11.7 7.4 50.9 5.6 36.4 7.3 2.5 6.3 46.4 6.9 10.3 163.9 45.1 10.1 13.5 45.5 10.1 2.7 104.7 45.6 6.4 8.8 17.5 14.8 8.0 15.4 2.8 2.0 11.7 10.5 13.1 14.8 13.2 13.3 12.9 74.5 4.8 5.3 5.6 10.6 25.1 10.0 14.1 567.6 19.6 90.8 15.0 13.9 6.2 21.7 58.7 5.9 8.4 15.3 9.2 12.1 5.5 9.8 97.8 675.0 8.4 12.6 8.4 45.2 165.2 6.1 22.7 9.9 5.4 703.9 14.9 2.6 5.4 7.8 11.5 8.0 8.3 36.9 19.3 29.8 3.6 3.5 2.5 3.1 10.6 1218.7 1160.5 144.1 14.0 19.0 3.7 279.1 8.2 77.7 60.4 9.7 102.3 124.8 165.9 85.6 13.2 73.5 172.4 113.3 195.5 92.7 17.4 15.2 331.9 79.0 10.9 11.4 9.6 12.3 15.4 12.4 9.7 10.7 11.7 10.3 13.5 8.8 2.9 12.8 36.0 1.0 161.6 20.3 9.0 7.1 45.5 2.6 16.2 4.7 3.5 2.8 9.9 3.7 2.1 5.8 46.8 5.7 3.9 3.3 1.9 15.6 1.0 5.3 13.1 49.9 2.3 3.5 9.1 5.1 10.7 3.9 23.4 1.3 4.2 6.3 7.2 11.8 2.2 7.5 18.3 7.5 123.1 1.8 1.8 19.8 94.3 0.0 99.5 2.2 38.1 0.5 1.0 2.0 3.7 4.1 738.8 4.6 4.1 6.8 16.3 2.1 0.0 3.8 6.2 2.2 1.6 15.7 13.8 2.5 97.1 8.6 11.8 3.4 PIM3 ENSG00000198355 "Pim-3 proto-oncogene, serine/threonine kinase" Q86V86 22 49960768-49964072 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Langerhans cells: 408.4;Syncytiotrophoblasts: 389.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 20.7" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Karpas-707: 163.3;SK-BR-3: 144.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA068758 Supported Cytosol NA Yes "Cluster 9: Neutrophils - Innate immune response" "Cluster 72: Non-specific - Transcription" "Cluster 2: Karpas-707 - Immune response" "Cluster 41: Macrophages - Immune response" Cytosol "HPA068758: AB_2686026" "unprognostic (3.67e-2)" "unprognostic (7.69e-3)" "unprognostic (1.07e-1)" "unprognostic (1.11e-1)" "unprognostic (3.67e-2)" "unprognostic (5.83e-2)" "unprognostic (1.48e-2)" "unprognostic (1.13e-2)" "unprognostic (2.71e-2)" "prognostic unfavorable (9.68e-4)" "unprognostic (2.00e-2)" "unprognostic (1.00e-1)" "prognostic favorable (8.09e-4)" "unprognostic (5.59e-3)" "unprognostic (1.71e-1)" "unprognostic (3.92e-3)" "unprognostic (7.27e-3)" 97.8 48.4 25.9 31.3 31.3 114.3 80.2 32.8 38.1 49.2 26.9 55.1 23.8 40.8 12.7 80.8 54.0 25.8 68.7 25.2 32.6 113.3 92.9 107.1 28.2 40.6 36.1 35.7 73.1 21.6 51.3 21.3 38.0 87.3 10.4 3.1 93.5 22.6 112.0 116.4 51.6 9.9 30.3 80.7 118.1 33.9 35.2 19.0 54.9 35.0 13.0 71.0 68.6 39.9 26.8 17.7 11.6 21.9 9.0 6.7 65.5 16.5 26.7 19.4 14.0 29.5 22.3 47.3 20.1 4.6 39.1 22.5 22.3 12.6 6.9 35.8 92.1 19.5 46.3 36.0 41.8 42.5 36.0 12.8 41.0 11.9 20.2 10.5 63.5 31.7 27.0 163.3 5.9 60.6 21.7 76.4 24.2 28.1 27.8 100.3 19.2 57.6 10.6 20.3 41.1 28.6 32.2 144.7 109.2 10.7 19.0 56.4 16.8 12.1 51.5 19.8 27.1 82.2 56.9 41.4 30.1 24.1 33.2 0.0 4.0 0.1 2.2 4.1 2.5 4.3 5.0 4.4 3.1 7.5 4.8 1.9 20.7 1.7 5.2 7.0 5.8 2.7 25.9 31.3 32.8 38.1 25.2 32.6 40.6 36.1 38.0 30.3 35.2 39.9 120.2 64.1 85.9 6.5 107.7 227.3 236.8 79.1 96.8 31.5 99.2 67.3 32.8 121.5 72.8 80.9 2.1 56.9 79.5 57.9 84.1 50.9 5.1 114.2 76.3 167.7 97.7 10.8 10.2 54.5 346.5 69.0 202.3 170.5 69.3 16.8 98.6 45.9 69.7 62.2 6.7 101.7 81.4 41.1 408.4 4.8 32.3 134.8 108.5 6.5 35.8 14.0 11.3 6.6 20.5 71.0 94.6 11.3 95.1 298.4 58.1 88.5 40.9 16.5 26.3 39.4 57.3 26.1 37.7 95.3 204.7 389.9 90.4 11.6 79.0 266.0 PINK1 "BRPK, PARK6" ENSG00000158828 "PTEN induced kinase 1" Q9BXM7 1 20633458-20651511 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Autophagy "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Neurodegeneration, Parkinson disease, Parkinsonism, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 384.4;tongue: 392.3" "Cell type enhanced" "Detected in many" "Late spermatids: 151.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 8.1" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001931, CAB026191" Enhanced NA NA "Cluster 10: Basophils - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" "CAB026191: , HPA001931: AB_1079620" "unprognostic (3.73e-3)" "unprognostic (2.29e-2)" "unprognostic (3.22e-1)" "unprognostic (4.33e-2)" "unprognostic (4.91e-2)" "unprognostic (2.93e-2)" "unprognostic (1.56e-2)" "unprognostic (3.36e-2)" "unprognostic (3.51e-2)" "unprognostic (4.06e-3)" "unprognostic (3.34e-2)" "unprognostic (2.54e-1)" "prognostic favorable (1.11e-16)" "unprognostic (2.68e-1)" "unprognostic (1.62e-1)" "unprognostic (6.57e-2)" "unprognostic (1.08e-1)" 50.7 127.2 119.3 13.7 103.4 13.0 41.9 104.6 110.9 37.9 73.0 62.3 32.3 43.9 18.8 48.8 34.4 23.5 153.4 106.6 107.0 56.8 76.8 30.1 10.8 118.5 127.8 30.1 52.7 66.5 33.4 21.3 118.3 37.1 15.0 29.4 55.0 29.7 384.4 55.3 35.2 20.0 124.9 27.9 46.7 94.8 132.1 12.3 41.6 392.3 8.3 47.4 42.7 95.0 49.9 22.2 10.3 29.6 34.6 32.8 10.7 68.2 67.9 32.4 56.1 7.7 39.3 11.7 52.6 69.9 75.4 22.5 15.0 36.2 16.0 14.0 56.8 5.9 60.3 12.1 26.8 6.3 17.7 30.8 38.5 40.6 13.9 36.2 21.3 10.7 14.5 14.5 23.6 21.2 9.2 14.1 4.6 12.9 72.2 7.9 18.0 9.4 20.1 11.5 37.8 14.8 74.4 24.2 20.8 12.3 8.0 21.6 32.6 29.1 14.9 49.2 9.7 16.7 3.6 5.4 63.1 17.9 14.0 3.6 1.6 3.7 0.8 1.1 1.0 0.2 0.7 1.1 0.5 1.4 0.5 0.8 8.1 0.6 3.9 1.0 1.5 0.6 119.3 103.4 104.6 110.9 106.6 107.0 118.5 127.8 118.3 124.9 132.1 95.0 38.7 22.4 19.2 16.3 9.1 15.7 36.0 7.9 10.8 50.1 31.5 24.4 1.1 37.1 9.2 44.1 37.5 26.3 9.2 107.4 80.3 24.0 77.7 22.3 16.1 48.5 20.0 56.0 27.2 28.0 31.8 27.4 12.2 26.4 0.0 36.7 84.3 110.5 23.7 28.6 24.4 30.2 12.2 27.1 16.3 151.4 35.4 22.7 21.4 25.3 10.1 69.7 12.3 8.5 14.3 56.6 67.9 56.8 27.0 67.5 66.9 109.2 7.6 69.0 85.5 30.9 32.2 120.8 24.6 19.3 24.0 34.2 10.6 34.2 24.4 47.9 PIP4K2A "PIP5K2A, PIP5KIIA, PIP5KIIalpha" ENSG00000150867 "Phosphatidylinositol-5-phosphate 4-kinase type 2 alpha" P48426 10 22534854-22714578 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 6 "brain: 498.1" "Cell type enriched" "Detected in many" 6 "Oligodendrocytes: 1585.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA065440, HPA068771" Supported Approved "Golgi apparatus,Plasma membrane,Cytosol" NA NA 4900000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 70: Brain - Nervous system development" "Cluster 2: Karpas-707 - Immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Golgi apparatus" "Plasma membrane, Cytosol" "HPA065440: AB_2685490, HPA068771: AB_2686030" "unprognostic (1.11e-1)" "unprognostic (2.71e-3)" "unprognostic (1.57e-3)" "unprognostic (4.20e-3)" "unprognostic (1.55e-1)" "unprognostic (8.80e-3)" "unprognostic (1.56e-3)" "unprognostic (7.32e-2)" "unprognostic (1.68e-1)" "unprognostic (7.08e-2)" "unprognostic (1.29e-1)" "unprognostic (1.21e-1)" "prognostic unfavorable (1.46e-4)" "unprognostic (1.52e-3)" "unprognostic (2.51e-1)" "unprognostic (1.38e-1)" "unprognostic (7.92e-3)" 28.4 15.5 162.5 47.8 329.4 44.8 15.0 239.0 239.9 26.5 49.8 17.8 13.2 21.1 11.8 19.8 15.2 32.9 13.5 169.7 193.6 16.5 18.6 25.9 81.2 260.6 273.4 8.8 10.9 24.8 8.5 23.7 271.7 9.3 19.1 15.3 7.8 13.0 5.1 8.3 20.6 31.5 171.8 62.6 19.3 12.5 233.3 60.4 12.8 10.9 88.5 24.1 10.5 498.1 30.2 29.2 33.4 10.8 52.3 70.6 25.3 55.0 58.1 29.1 35.7 27.6 47.2 63.2 19.4 111.0 63.7 10.4 29.2 15.4 29.2 140.5 30.4 118.7 21.6 60.9 92.5 23.1 89.1 35.6 13.7 39.7 38.2 44.6 43.7 83.5 67.4 119.1 54.5 12.5 92.3 20.5 13.7 14.5 20.7 36.9 47.8 86.3 43.0 5.8 6.1 13.9 17.7 9.0 86.4 37.6 7.6 39.1 53.0 22.3 32.8 41.7 33.9 75.1 46.3 45.0 60.5 68.3 17.6 72.6 32.6 104.0 119.5 57.9 164.0 52.1 94.2 139.9 43.7 33.1 62.8 118.2 40.5 144.2 67.3 44.8 75.9 183.4 162.5 329.4 239.0 239.9 169.7 193.6 260.6 273.4 271.7 171.8 233.3 498.1 22.5 3.2 6.7 84.9 43.2 17.6 4.0 2.0 3.4 5.7 12.9 5.5 8.1 14.3 5.6 18.4 2.1 8.6 196.9 3.4 11.7 9.7 22.9 7.4 15.7 29.2 4.9 236.9 65.6 10.7 5.4 19.6 6.6 24.8 22.8 13.4 62.4 8.7 31.8 13.5 62.0 2.9 0.0 98.6 80.0 34.5 16.8 82.8 104.9 142.4 81.3 5.0 159.6 167.9 1585.0 22.1 3.7 10.1 36.4 7.1 1.0 15.6 2.2 9.1 19.7 14.1 30.6 6.1 7.9 3.3 16.9 12.4 130.7 8.5 2.8 6.6 PIP4K2B "PIP5K2B, PIP5KIIB, PIP5KIIbeta" ENSG00000276293 "Phosphatidylinositol-5-phosphate 4-kinase type 2 beta" P78356 17 38765691-38800126 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA062220 Supported Nucleoplasm NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 80: Striated muscle - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 52: Non-specific - Transcription" Nucleoplasm "HPA062220: AB_2684715" "unprognostic (7.77e-2)" "unprognostic (8.37e-2)" "unprognostic (3.74e-2)" "unprognostic (1.13e-1)" "unprognostic (2.67e-1)" "unprognostic (1.91e-1)" "prognostic unfavorable (4.54e-4)" "unprognostic (2.64e-1)" "unprognostic (2.33e-1)" "unprognostic (1.50e-2)" "unprognostic (6.10e-3)" "unprognostic (3.79e-1)" "unprognostic (4.82e-3)" "unprognostic (3.38e-2)" "unprognostic (3.22e-1)" "prognostic favorable (1.36e-4)" "unprognostic (2.48e-1)" 19.9 27.0 82.5 15.5 85.6 7.3 20.8 62.3 93.9 30.1 43.3 24.2 10.3 28.8 23.3 15.4 29.1 16.3 30.2 90.7 75.2 20.1 14.4 21.4 20.5 65.9 65.7 49.8 16.4 16.6 25.2 22.8 67.1 22.2 14.0 36.0 16.9 25.3 99.0 24.6 17.3 29.5 63.2 23.2 16.4 13.0 80.4 23.4 20.3 75.6 20.4 22.9 20.9 81.4 18.1 40.2 66.0 69.9 56.7 45.5 12.2 31.6 38.2 43.1 35.0 28.2 18.4 44.8 17.2 59.8 36.3 35.9 44.9 28.7 41.4 27.8 17.2 38.4 27.3 40.7 26.2 43.7 23.5 40.0 34.2 33.7 24.2 59.2 36.3 48.6 34.2 22.3 46.8 14.2 44.0 34.0 32.0 20.7 15.8 44.6 63.7 25.6 31.3 22.3 34.0 46.1 30.9 13.9 34.5 68.5 43.6 44.5 33.4 35.8 21.6 29.4 28.9 27.4 36.5 19.7 42.0 36.8 32.9 1.3 1.9 0.6 3.4 1.6 3.5 2.3 2.9 3.3 2.4 2.3 3.2 2.9 1.8 2.8 1.4 2.2 3.0 3.3 82.5 85.6 62.3 93.9 90.7 75.2 65.9 65.7 67.1 63.2 80.4 81.4 15.8 19.2 11.4 21.5 6.7 6.1 3.5 4.6 7.4 31.6 11.5 13.3 23.4 4.3 7.5 5.5 10.4 7.0 14.8 3.7 1.9 5.3 9.2 10.8 17.7 17.3 11.5 9.0 33.5 4.9 5.0 13.8 5.6 9.0 1.3 22.6 18.2 12.7 8.8 43.7 29.1 7.4 2.0 11.3 4.9 21.1 15.2 8.6 1.8 18.7 6.9 14.8 10.3 22.1 24.0 6.0 4.1 16.6 6.2 4.9 5.4 7.7 6.4 14.0 6.6 13.8 13.2 4.6 7.4 9.9 4.4 2.5 8.1 17.3 7.2 2.7 PIP4K2C "FLJ22055, PIP5K2C" ENSG00000166908 "Phosphatidylinositol-5-phosphate 4-kinase type 2 gamma" Q8TBX8 12 57591174-57603418 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cardiomyocytes: 121.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "RH-30: 130.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA028658 Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 43: Cardiomyocytes - Nuclear processes" Cytosol "Nucleoplasm, Plasma membrane" "HPA028658: AB_10601245" "unprognostic (7.84e-3)" "unprognostic (1.51e-1)" "unprognostic (2.42e-1)" "unprognostic (2.77e-2)" "unprognostic (2.49e-2)" "unprognostic (3.37e-2)" "prognostic unfavorable (7.98e-4)" "unprognostic (3.17e-2)" "unprognostic (6.00e-2)" "unprognostic (5.51e-2)" "unprognostic (1.75e-1)" "unprognostic (1.88e-1)" "prognostic favorable (2.06e-6)" "unprognostic (1.87e-1)" "unprognostic (2.16e-1)" "unprognostic (3.27e-1)" "unprognostic (3.42e-1)" 13.6 17.2 18.4 11.6 24.0 26.5 20.0 13.4 32.8 18.4 20.7 24.1 16.0 18.5 81.6 28.2 26.6 16.1 15.0 22.3 11.5 36.0 14.8 19.7 13.5 14.9 13.0 16.0 21.0 39.1 18.7 12.1 16.0 21.6 26.3 29.1 25.6 18.4 14.0 27.1 19.2 15.9 11.9 14.6 39.8 28.1 15.7 11.4 22.4 10.5 18.8 18.2 20.5 20.9 52.0 36.4 14.8 17.6 0.0 0.1 47.0 21.4 40.6 38.7 35.1 46.7 73.4 11.3 44.1 25.6 47.4 46.1 24.2 42.2 30.3 15.9 26.1 20.0 17.5 33.7 32.8 19.3 35.0 12.9 70.0 14.7 26.9 46.4 19.6 12.1 26.8 33.3 20.0 52.6 16.5 16.7 28.1 32.1 31.2 0.5 130.9 17.2 39.6 91.1 23.7 30.0 45.8 30.4 29.7 49.3 83.2 17.8 4.2 18.5 26.1 27.7 22.8 25.1 31.5 25.6 36.0 16.0 32.1 58.8 8.2 25.8 24.3 10.5 16.1 8.7 14.8 18.4 8.6 11.0 13.8 16.7 16.3 16.2 14.6 3.8 19.9 11.0 18.4 24.0 13.4 32.8 22.3 11.5 14.9 13.0 16.0 11.9 15.7 20.9 4.1 9.6 8.6 4.9 6.9 12.4 6.2 11.7 10.8 14.3 13.2 8.0 121.7 12.8 11.9 35.0 18.8 11.3 7.4 33.7 21.5 17.7 25.7 14.2 4.2 8.8 22.2 5.2 28.0 19.7 15.2 5.4 26.0 20.3 3.8 4.0 9.3 12.6 8.9 8.4 11.8 18.4 10.2 6.0 2.2 47.9 6.8 5.7 12.4 2.8 5.9 7.5 5.2 5.0 11.5 40.5 12.8 5.3 9.4 10.1 14.2 13.3 15.3 8.1 19.7 3.8 13.1 12.0 9.0 14.3 12.8 17.4 11.9 5.5 10.4 9.2 PIP5K1A ENSG00000143398 "Phosphatidylinositol-4-phosphate 5-kinase type 1 alpha" Q99755 1 151197949-151249536 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA029366 Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 23: Testis - Cell cycle regulation" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 44: Endometrium - Transcription" "Plasma membrane, Cytosol" Nucleoplasm "HPA029366: AB_10602116" "unprognostic (1.05e-1)" "unprognostic (2.36e-2)" "unprognostic (8.64e-2)" "unprognostic (7.94e-3)" "unprognostic (1.17e-1)" "unprognostic (3.28e-2)" "unprognostic (1.26e-2)" "unprognostic (3.01e-1)" "unprognostic (8.79e-2)" "unprognostic (1.15e-1)" "unprognostic (1.37e-1)" "unprognostic (1.04e-1)" "prognostic unfavorable (4.16e-7)" "unprognostic (1.44e-1)" "unprognostic (8.14e-2)" "unprognostic (2.93e-1)" "unprognostic (1.59e-1)" 20.1 19.1 16.0 16.1 17.3 9.7 19.5 17.8 19.2 18.9 20.8 17.2 16.2 18.8 21.1 20.4 18.9 19.7 19.8 16.8 17.3 21.9 18.6 21.8 18.7 15.1 15.7 18.7 13.6 23.0 21.5 25.9 14.7 16.7 15.1 30.1 16.9 14.1 29.2 21.0 16.9 20.3 14.2 19.0 16.6 35.1 16.9 24.7 18.4 25.4 20.1 20.5 17.4 18.4 49.3 37.4 57.7 67.6 37.5 38.8 56.7 63.5 89.3 116.6 103.7 68.7 46.8 43.9 66.8 67.9 52.7 42.0 75.7 42.6 101.2 68.8 54.0 36.0 48.4 33.9 70.1 64.9 43.8 51.1 40.3 72.7 90.7 52.1 48.8 69.4 35.6 36.7 60.4 69.9 63.6 32.4 86.0 38.2 58.3 60.5 50.7 34.1 61.2 27.1 38.6 49.4 87.1 66.6 57.4 96.4 69.2 59.4 47.4 46.6 64.7 42.6 77.0 50.5 93.6 99.3 44.7 18.6 56.6 0.1 3.9 5.7 3.7 4.7 2.8 6.6 3.3 4.1 6.4 3.0 3.7 2.9 8.9 3.9 3.8 6.7 3.1 4.7 16.0 17.3 17.8 19.2 16.8 17.3 15.1 15.7 14.7 14.2 16.9 18.4 11.6 32.1 12.2 43.8 21.3 66.2 23.2 17.0 39.9 34.1 31.3 22.0 18.4 17.2 15.3 31.3 98.0 25.9 18.3 12.7 9.8 13.5 4.9 64.0 26.2 15.6 6.0 12.4 59.6 8.7 29.3 19.8 19.4 71.0 12.0 19.9 14.3 14.3 12.8 26.9 51.2 9.7 18.3 10.7 29.5 4.8 13.4 14.9 12.4 44.0 12.2 12.5 9.2 54.8 64.0 19.4 8.9 10.9 16.8 20.9 21.0 10.1 18.4 43.0 13.1 17.4 20.9 52.1 24.6 38.4 50.0 63.5 15.9 18.4 10.7 39.4 PIP5K1B "MSS4, STM7" ENSG00000107242 "Phosphatidylinositol-4-phosphate 5-kinase type 1 beta" O14986 9 68705240-69009176 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 97.3" "Cell type enhanced" "Detected in many" "Distal enterocytes: 127.4;Early spermatids: 100.0;Inhibitory neurons: 270.1;Muller glia cells: 120.2" "Group enriched" "Detected in many" 4 "colorectal cancer: 10.1;pancreatic cancer: 3.4;stomach cancer: 9.4;testis cancer: 3.6" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 6 "eosinophil: 34.5" "Lineage enriched" "Detected in many" 6 "granulocytes: 34.5" "Cell line enhanced" "Detected in some" "AF22: 43.8;HEL: 17.0;Hep G2: 13.4;OE19: 73.1;U-266/70: 17.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA009687 Uncertain Approved Nucleoplasm,Vesicles NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 21: OE19 - Mitochondria" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm Vesicles "HPA009687: AB_1855391" "unprognostic (2.02e-3)" "unprognostic (1.84e-2)" "unprognostic (3.77e-2)" "unprognostic (2.72e-1)" "unprognostic (1.56e-1)" "unprognostic (1.62e-1)" "unprognostic (5.85e-3)" "unprognostic (1.80e-2)" "unprognostic (1.38e-2)" "unprognostic (1.17e-1)" "unprognostic (2.98e-2)" "unprognostic (2.92e-2)" "prognostic favorable (1.03e-9)" "unprognostic (2.10e-2)" "unprognostic (1.71e-1)" "unprognostic (1.19e-1)" "unprognostic (3.34e-1)" 4.2 11.9 5.6 6.0 5.3 16.1 4.9 18.4 8.1 6.3 97.3 31.2 34.8 7.5 1.7 1.2 6.0 4.0 32.2 12.3 10.7 7.8 0.3 12.9 2.6 7.9 11.2 1.0 8.6 13.7 6.6 6.5 6.3 3.1 29.1 38.0 16.4 9.6 2.9 2.3 30.8 2.9 4.0 2.6 26.1 24.7 11.4 1.0 1.2 5.1 3.6 3.3 2.5 3.7 0.0 0.0 43.8 0.0 0.1 0.0 8.5 0.0 0.0 0.0 0.0 4.6 0.0 3.6 0.1 0.0 0.1 0.1 0.4 0.1 0.0 0.0 0.8 17.0 0.3 13.4 0.0 0.9 4.4 0.0 2.0 0.0 0.0 0.0 0.1 0.5 0.9 9.3 0.3 1.1 0.1 0.2 2.3 73.1 1.4 1.4 0.1 0.3 0.3 3.4 0.9 0.1 0.0 0.1 0.5 1.0 0.2 0.1 0.1 0.0 0.4 0.1 0.0 17.0 3.5 2.3 0.0 3.1 0.0 5.6 0.5 34.5 0.0 0.0 0.0 4.7 0.3 0.1 0.1 5.4 0.7 0.1 1.7 0.0 0.2 1.4 1.6 0.3 5.6 5.3 18.4 8.1 12.3 10.7 7.9 11.2 6.3 4.0 11.4 3.7 3.6 35.3 34.4 28.7 19.2 0.6 3.2 0.5 0.6 5.1 4.7 3.3 61.6 2.8 2.8 5.5 2.1 21.3 0.0 127.4 27.4 1.6 100.0 12.8 13.6 3.3 37.0 53.6 84.7 14.0 1.3 3.1 40.2 27.5 5.7 3.8 1.4 0.0 3.9 0.0 270.1 32.6 14.2 1.0 1.3 47.6 2.5 5.6 5.4 60.0 2.6 120.2 0.0 80.9 6.4 5.2 46.6 1.5 43.2 2.5 39.2 1.4 6.5 3.3 26.3 2.5 32.2 39.0 4.5 0.7 0.3 8.8 2.1 0.9 29.7 9.8 PIP5K1C "KIAA0589, LCCS3, PIP5Kgamma" ENSG00000186111 "Phosphatidylinositol-4-phosphate 5-kinase type 1 gamma" O60331 19 3630183-3700468 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell adhesion, Chemotaxis, Endocytosis, Exocytosis, Phagocytosis" "Kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "Bipolar cells: 56.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in all" "U-2197: 75.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017168 Approved Approved Nucleoplasm,Cytosol No No "Cluster 10: Basophils - Unknown function" "Cluster 78: Testis - Spermatogenesis" "Cluster 18: U-2197 - ECM organization" "Cluster 56: Bipolar cells - Visual perception" "Nucleoplasm, Cytosol" "HPA017168: AB_1855395" "unprognostic (1.20e-1)" "prognostic favorable (1.79e-4)" "unprognostic (1.36e-3)" "prognostic favorable (7.28e-5)" "unprognostic (7.03e-2)" "unprognostic (4.02e-3)" "unprognostic (5.80e-3)" "unprognostic (8.50e-2)" "unprognostic (1.31e-1)" "unprognostic (2.57e-3)" "prognostic favorable (2.32e-4)" "unprognostic (1.51e-1)" "prognostic favorable (3.00e-4)" "unprognostic (2.25e-1)" "unprognostic (1.84e-1)" "unprognostic (2.30e-1)" "unprognostic (2.70e-1)" 22.1 15.6 30.7 11.5 36.6 3.4 19.2 19.4 66.4 24.0 0.0 62.2 8.6 44.9 7.6 20.3 29.8 8.2 32.2 40.2 5.0 15.8 8.7 22.6 6.5 13.3 7.7 22.2 18.0 10.7 20.6 11.2 12.9 33.9 4.5 13.2 18.1 25.1 17.7 16.0 24.1 16.0 0.0 22.4 29.7 61.4 19.5 5.3 21.1 4.8 4.2 39.4 24.7 33.2 18.9 18.0 13.4 18.0 25.5 21.0 20.3 36.1 22.4 15.2 12.3 16.1 5.2 7.8 13.6 39.0 16.5 16.4 6.5 11.7 6.2 28.7 11.9 9.0 15.0 13.1 22.0 9.4 26.7 23.7 9.9 12.4 4.1 9.9 25.6 11.5 14.1 13.5 14.4 15.7 11.2 6.6 14.4 6.8 24.6 21.4 7.2 11.2 11.5 15.9 13.7 12.0 18.7 10.1 11.1 16.6 7.9 14.1 57.3 21.3 11.8 75.1 17.0 16.0 14.3 3.5 27.6 19.2 15.0 1.0 0.7 0.0 0.7 0.5 0.2 0.6 0.5 0.4 0.8 0.3 0.2 0.4 0.5 0.5 0.8 0.5 0.4 0.6 30.7 36.6 19.4 66.4 40.2 5.0 13.3 7.7 12.9 0.0 19.5 33.2 20.3 6.4 5.0 8.8 6.2 5.4 3.0 6.1 7.4 56.8 9.6 6.6 7.5 7.2 3.0 16.5 37.5 7.8 10.6 12.2 1.9 7.9 11.6 6.4 29.0 22.1 8.4 2.1 30.6 7.1 7.4 10.7 7.1 11.6 1.3 10.7 16.1 4.0 15.7 30.3 17.9 9.7 6.1 19.6 13.2 24.0 14.9 15.5 5.4 22.5 15.0 14.3 11.3 9.0 6.8 12.1 13.2 24.0 5.7 4.4 7.2 6.4 4.1 26.8 13.1 8.4 10.4 18.6 11.8 7.8 6.8 16.4 8.0 11.9 7.2 5.3 PIP5KL1 "bA203J24.5, MGC46424" ENSG00000167103 "Phosphatidylinositol-4-phosphate 5-kinase like 1" Q5T9C9 9 127920881-127930785 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Early spermatids: 22.6;Late spermatids: 24.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in many" 5 "Karpas-707: 45.5;RPMI-8226: 31.5" "Low region specificity" "Detected in many" "Low region specificity" "Detected in some" HPA056240 Uncertain Supported Cytosol NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 2: Karpas-707 - Immune response" "Cluster 34: Spermatids - Unknown function" Cytosol "HPA056240: AB_2683075" "unprognostic (2.15e-2)" "unprognostic (3.06e-1)" "unprognostic (1.23e-3)" "unprognostic (8.51e-5)" "unprognostic (1.44e-2)" "unprognostic (4.62e-2)" "unprognostic (1.19e-1)" "unprognostic (6.29e-2)" "unprognostic (5.20e-2)" "unprognostic (5.50e-2)" "unprognostic (2.49e-2)" "unprognostic (1.57e-3)" "unprognostic (9.95e-8)" "unprognostic (1.87e-1)" "unprognostic (7.21e-2)" "unprognostic (6.05e-2)" "unprognostic (1.59e-1)" 0.6 0.2 1.0 0.0 1.0 0.6 1.7 1.6 1.8 2.3 0.2 1.0 0.1 1.3 0.2 3.2 1.7 0.3 0.2 0.9 1.0 1.3 0.2 1.9 0.1 2.1 0.8 0.9 1.3 2.9 3.8 0.6 2.4 3.1 0.0 0.2 3.2 1.4 0.1 3.9 0.5 0.3 0.7 0.6 1.4 2.5 1.3 0.1 1.7 0.0 0.2 1.0 3.6 1.0 0.0 0.7 0.7 0.8 0.8 1.9 4.1 0.8 0.8 0.2 0.2 0.3 5.5 0.5 1.6 3.7 1.6 1.7 0.0 4.1 0.2 0.3 2.7 0.0 1.4 0.1 1.3 0.0 0.2 2.1 2.6 0.6 0.0 1.3 0.0 3.7 0.0 45.5 0.0 4.0 0.0 1.6 0.4 1.7 0.6 0.4 0.1 31.5 0.0 0.1 1.4 2.7 0.3 1.0 0.0 0.4 1.7 2.2 0.6 0.5 1.3 0.9 0.1 4.0 2.8 1.0 8.0 0.6 0.5 0.0 0.0 0.0 0.0 0.2 0.2 0.2 0.0 0.0 0.2 0.4 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 1.0 1.0 1.6 1.8 0.9 1.0 2.1 0.8 2.4 0.7 1.3 1.0 0.5 0.0 9.3 0.3 1.1 2.2 4.7 5.1 8.6 0.7 3.2 4.7 0.5 0.0 2.0 5.5 0.0 0.9 1.5 0.6 1.9 1.4 22.6 2.3 3.5 0.8 0.0 3.2 0.9 1.5 4.4 0.9 7.7 4.1 0.0 1.7 0.4 0.3 0.3 5.0 1.7 0.4 2.0 0.3 0.6 24.6 0.9 0.3 0.0 0.0 0.2 1.9 0.0 0.0 0.1 1.2 0.1 0.4 2.0 2.9 0.1 0.1 7.4 0.8 0.0 1.0 1.3 1.8 2.2 2.3 1.1 3.1 0.9 1.2 0.7 2.1 PJA1 "FLJ11830, RNF70" ENSG00000181191 "Praja ring finger ubiquitin ligase 1" Q8NG27 X 69160851-69165521 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "epididymis: 160.0" "Cell type enhanced" "Detected in many" "Early spermatids: 74.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HAP1: 99.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000595 Approved Approved Nucleoplasm,Nucleoli NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 29: Early spermatids - Spermatogenesis" "Nucleoplasm, Nucleoli" "HPA000595: AB_1079826" "unprognostic (3.40e-2)" "unprognostic (2.28e-1)" "unprognostic (4.03e-2)" "unprognostic (2.58e-3)" "unprognostic (5.44e-2)" "unprognostic (1.30e-2)" "unprognostic (1.26e-3)" "unprognostic (4.61e-2)" "unprognostic (3.82e-3)" "unprognostic (1.84e-2)" "unprognostic (6.10e-2)" "unprognostic (1.60e-1)" "prognostic favorable (7.44e-5)" "unprognostic (1.49e-1)" "unprognostic (2.35e-1)" "unprognostic (2.01e-1)" "unprognostic (2.10e-1)" 22.9 14.5 46.8 8.7 50.5 3.6 19.4 37.2 78.0 19.9 33.0 15.4 6.4 16.4 160.0 12.3 16.0 11.1 15.0 47.1 48.9 19.2 9.4 13.8 10.0 38.9 41.7 25.8 14.5 38.7 28.1 17.3 40.6 15.3 7.6 17.6 10.6 32.4 7.9 14.6 11.1 16.0 40.1 13.3 14.0 26.4 49.0 10.0 22.7 8.8 12.1 17.4 15.1 43.5 27.3 19.6 62.9 43.7 21.3 22.5 18.7 17.8 22.0 16.7 22.3 17.1 25.8 4.4 26.7 28.1 39.2 24.0 99.0 34.9 21.2 20.2 33.0 8.1 16.0 10.9 25.7 4.9 14.4 23.1 23.6 28.6 17.0 15.8 19.0 13.2 7.8 3.0 16.9 14.1 2.1 8.4 43.4 23.1 32.0 20.0 28.2 6.9 23.4 22.6 46.4 30.7 28.6 4.9 22.2 50.1 7.7 7.0 17.8 13.9 22.6 41.7 8.3 0.0 0.2 9.1 15.3 13.1 19.4 6.6 6.8 2.1 29.6 9.2 34.3 16.4 26.1 27.5 7.3 22.8 26.5 31.3 2.3 30.0 6.5 8.9 17.5 19.4 46.8 50.5 37.2 78.0 47.1 48.9 38.9 41.7 40.6 40.1 49.0 43.5 4.7 16.0 4.8 2.9 9.7 41.0 19.4 30.8 23.9 16.8 5.0 6.2 7.1 4.3 14.8 3.7 8.4 35.6 5.9 1.0 15.6 24.9 74.7 3.9 10.4 6.6 5.4 10.8 8.1 11.7 15.3 18.2 7.1 5.8 4.5 27.9 6.8 1.7 7.0 5.0 8.3 3.6 6.1 2.9 9.9 32.7 27.1 5.7 5.4 2.8 2.9 30.6 14.4 5.0 3.7 18.0 1.7 19.5 7.7 17.0 0.5 6.5 4.4 6.1 6.6 9.4 16.3 1.4 1.5 11.2 29.5 20.8 11.2 27.0 2.6 22.5 PJA2 "KIAA0438, Neurodap1, RNF131" ENSG00000198961 "Praja ring finger ubiquitin ligase 2" O43164 5 109334713-109409974 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA040347, HPA057636" Supported Enhanced "Intermediate filaments" No No "Cluster 14: Monocytes - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 30: Epithelial cell lines - Translation" "Cluster 43: Cardiomyocytes - Nuclear processes" "Intermediate filaments" "HPA040347: AB_10795631, HPA057636: AB_2683485" "unprognostic (5.78e-2)" "unprognostic (1.25e-1)" "unprognostic (5.48e-3)" "unprognostic (1.17e-1)" "unprognostic (2.99e-1)" "unprognostic (7.83e-2)" "unprognostic (2.83e-1)" "unprognostic (4.33e-2)" "unprognostic (4.84e-2)" "prognostic unfavorable (8.02e-4)" "unprognostic (4.46e-2)" "unprognostic (6.03e-2)" "unprognostic (5.64e-3)" "unprognostic (1.47e-3)" "unprognostic (5.94e-2)" "unprognostic (7.59e-2)" "unprognostic (1.00e-2)" 59.3 67.9 63.3 44.4 72.9 87.9 57.0 44.9 89.8 68.9 22.1 56.1 33.4 74.5 62.2 50.8 46.2 48.3 65.8 78.6 77.0 61.1 77.3 51.4 41.4 52.6 52.1 87.8 38.8 88.1 36.8 58.2 56.2 78.4 52.5 64.2 49.2 91.9 39.0 30.6 40.6 77.1 58.9 54.7 33.1 47.0 58.6 53.8 92.1 54.2 44.6 53.7 36.9 68.9 36.0 24.6 96.2 74.6 93.4 101.3 52.4 57.9 86.5 44.6 72.6 22.9 47.6 46.0 78.1 111.8 71.8 20.5 57.0 71.3 81.1 39.5 21.7 53.5 47.4 31.1 66.2 40.2 75.8 70.4 58.1 59.7 85.1 80.0 72.4 40.8 37.2 84.0 73.0 21.9 48.8 36.9 19.2 21.9 16.3 31.1 84.6 77.5 69.5 31.9 18.4 47.1 59.8 21.5 70.5 64.2 48.6 58.7 84.6 63.4 30.7 58.8 27.5 56.4 51.6 53.5 66.8 54.8 42.6 32.9 19.2 29.3 14.4 19.7 14.4 16.5 14.1 13.4 19.3 11.7 18.0 13.4 49.0 17.8 27.7 8.0 20.5 18.5 63.3 72.9 44.9 89.8 78.6 77.0 52.6 52.1 56.2 58.9 58.6 68.9 85.2 67.3 58.4 71.2 76.9 63.5 56.2 59.8 58.1 102.1 53.0 58.5 127.5 51.5 51.7 57.0 62.6 24.1 78.2 85.9 49.0 40.8 22.5 42.8 97.5 70.3 67.6 32.1 159.0 33.3 31.0 86.7 32.1 68.2 47.5 99.3 70.6 94.8 54.5 77.4 126.0 53.1 36.7 91.5 78.5 20.7 85.1 77.1 60.5 66.5 73.4 93.0 68.0 60.8 111.6 30.9 30.4 92.6 72.0 59.2 46.8 58.7 48.4 91.3 78.9 105.0 110.1 73.4 42.9 43.7 58.2 26.3 68.7 61.6 39.3 44.0 PKDCC "SgK493, Vlk" ENSG00000162878 "Protein kinase domain containing, cytoplasmic" Q504Y2 2 42048021-42058517 "Disease related genes, Enzymes, Potential drug targets, Predicted secreted proteins" "Differentiation, Osteogenesis, Protein transport, Transport" "Developmental protein, Kinase, Transferase, Tyrosine-protein kinase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 85.5" "Cell type enhanced" "Detected in many" "Enteroendocrine cells: 71.9;Fibroblasts: 55.4;Leydig cells: 137.6;Peritubular cells: 112.1;Rod photoreceptor cells: 95.9;Theca cells: 135.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AN3-CA: 85.9;ASC diff: 61.7;CACO-2: 101.0;HHSteC: 53.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026427, HPA026442, HPA026526" Approved "Secreted to blood" NA NA 80000 "Cluster 59: Non-specific - Translation" "Cluster 39: CACO-2 - Unknown function" "Cluster 52: Non-specific - Transcription" "HPA026427: AB_10600773, HPA026442: AB_10601237, HPA026526: AB_10602416" "unprognostic (6.77e-2)" "unprognostic (3.35e-1)" "unprognostic (1.04e-2)" "unprognostic (3.59e-3)" "unprognostic (8.31e-2)" "unprognostic (1.11e-1)" "unprognostic (2.18e-2)" "unprognostic (5.79e-3)" "unprognostic (1.04e-2)" "unprognostic (1.32e-1)" "unprognostic (3.20e-1)" "unprognostic (6.09e-2)" "unprognostic (2.14e-2)" "unprognostic (9.08e-2)" "unprognostic (2.62e-1)" "unprognostic (4.73e-3)" "unprognostic (2.58e-3)" 25.7 11.3 3.1 4.9 3.8 0.8 16.1 0.8 6.2 31.8 6.4 20.3 10.7 25.7 2.1 2.2 24.2 3.3 37.6 4.8 1.0 10.7 6.9 16.5 2.1 1.5 1.6 50.1 7.0 1.1 6.8 3.6 1.3 12.2 5.7 5.3 20.7 5.8 85.5 3.8 13.7 9.8 1.4 9.6 9.6 14.8 2.1 6.4 5.1 27.7 1.4 32.5 17.4 4.7 0.0 5.5 14.0 85.9 61.7 0.7 5.3 0.2 0.0 1.2 1.5 101.0 0.2 0.0 0.3 1.7 1.8 0.0 1.3 0.0 0.0 8.1 3.5 0.2 3.3 27.0 53.7 0.0 1.2 5.7 0.3 0.2 0.0 0.6 0.7 0.0 1.2 0.0 0.3 0.3 0.0 0.3 23.8 6.8 1.7 0.0 27.3 0.0 0.0 0.0 2.8 5.1 1.3 0.0 0.2 16.3 0.1 0.7 0.0 0.6 2.8 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.1 3.8 0.8 6.2 4.8 1.0 1.5 1.6 1.3 1.4 2.1 4.7 28.8 19.2 0.5 4.2 0.3 3.2 0.2 0.0 0.0 4.7 1.3 2.0 9.2 1.5 0.0 1.8 16.7 0.5 0.6 22.8 0.0 2.1 1.1 6.0 31.4 3.1 71.9 0.0 22.8 1.3 1.3 55.4 2.6 26.3 0.0 4.5 2.9 2.7 0.6 0.0 3.3 18.6 0.0 0.6 3.1 5.4 137.6 0.6 1.8 3.7 0.0 21.3 0.0 10.1 1.8 1.9 16.0 112.1 0.0 0.8 15.2 3.9 0.0 95.9 13.1 14.2 15.1 0.7 1.7 0.0 1.8 0.3 0.8 135.4 35.9 0.1 PKLR ENSG00000143627 "Pyruvate kinase L/R" P30613 1 155289293-155301438 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Glycolysis "Allosteric enzyme, Kinase, Transferase" "Disease variant, Hereditary hemolytic anemia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "bone marrow: 19.6;kidney: 25.1;liver: 92.5" "Cell type enhanced" "Detected in some" "Early spermatids: 9.3;Erythroid cells: 22.1;Hepatocytes: 16.3;Late spermatids: 23.0;Proximal enterocytes: 14.8;Proximal tubular cells: 48.9" "Cancer enriched" "Detected in some" 9 "liver cancer: 56.0" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 10 "K-562: 107.8" "Region enhanced" "Detected in single" "basal ganglia: 1.6" "Not detected" "Not detected" "HPA006653, CAB034376, CAB034378" Enhanced Approved Cytosol No NA 5200000 "Cluster 85: Liver - Metabolism" "Cluster 1: K-562 - Erythropoiesis" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Cytosol "CAB034376: AB_2163671, CAB034378: AB_2252321, HPA006653: AB_2667632" "unprognostic (9.16e-2)" "unprognostic (1.22e-1)" "unprognostic (2.22e-1)" "unprognostic (5.98e-2)" "unprognostic (2.62e-1)" "unprognostic (7.86e-4)" "unprognostic (1.53e-2)" "unprognostic (1.08e-1)" "unprognostic (8.79e-2)" "unprognostic (1.89e-1)" "unprognostic (4.07e-1)" "unprognostic (4.53e-2)" "unprognostic (1.96e-2)" "unprognostic (1.40e-1)" "unprognostic (1.02e-1)" "unprognostic (1.32e-1)" "unprognostic (6.21e-3)" 0.0 0.0 0.0 0.0 0.1 19.6 0.0 0.7 0.1 0.0 0.0 0.4 11.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 25.1 92.5 0.0 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.0 0.0 0.0 0.0 1.2 7.2 0.0 0.0 0.1 0.0 1.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 0.0 11.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 107.8 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.7 0.1 0.0 0.5 0.2 0.2 0.3 0.0 0.4 0.0 0.1 0.0 0.0 0.7 0.7 0.0 0.0 0.0 0.0 0.0 0.1 0.5 0.4 1.5 0.0 1.8 0.0 0.0 0.0 0.6 0.0 0.0 9.3 0.2 0.3 0.1 0.0 22.1 1.2 0.0 0.1 0.1 0.0 0.3 0.0 0.0 0.7 16.3 0.2 0.0 1.2 0.9 0.0 0.0 0.0 23.0 0.0 0.3 0.0 1.0 0.1 0.0 0.0 0.0 0.5 0.0 0.2 0.0 0.0 0.0 14.8 48.9 0.0 0.0 0.0 0.0 0.1 0.3 0.1 0.0 0.0 0.0 0.1 0.0 0.6 0.0 PKM "OIP3, PK3, PKM2, THBP1" ENSG00000067225 "Pyruvate kinase M1/2" P14618 15 72199029-72231822 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Glycolysis, Translation regulation" "Allosteric enzyme, Kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 4207.6;tongue: 2900.8" "Cell type enhanced" "Detected in all" "Basal respiratory cells: 2065.2;Late spermatids: 1763.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB019421, HPA029501" Uncertain Enhanced Cytosol No No 310000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 80: Striated muscle - Unknown function" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 16: Pancreatic endocrine cells - Mixed function" Cytosol "CAB019421: AB_2252325, HPA029501: AB_10602118" "unprognostic (8.73e-3)" "unprognostic (4.63e-3)" "unprognostic (1.68e-2)" "unprognostic (3.09e-1)" "unprognostic (6.51e-2)" "prognostic unfavorable (1.30e-4)" "prognostic unfavorable (2.74e-6)" "prognostic unfavorable (2.85e-4)" "unprognostic (9.51e-2)" "unprognostic (1.17e-2)" "prognostic unfavorable (5.17e-5)" "unprognostic (3.16e-1)" "unprognostic (3.22e-1)" "unprognostic (7.85e-2)" "unprognostic (3.17e-2)" "unprognostic (1.44e-1)" "unprognostic (1.25e-2)" 190.5 600.9 539.0 341.4 552.3 439.0 190.5 586.8 629.9 406.8 755.0 225.0 170.8 202.8 205.7 658.3 240.0 212.0 779.6 549.1 561.6 549.5 32.2 236.9 284.1 640.0 559.1 169.4 112.6 269.6 224.1 168.6 636.2 252.6 206.2 1266.7 389.8 291.6 4207.6 350.5 218.0 298.9 522.3 239.2 228.6 235.1 677.1 203.5 174.6 2900.8 429.2 578.5 374.9 530.6 1584.6 3937.1 788.9 938.8 914.3 1009.4 638.7 1684.6 3878.2 2619.1 2623.6 1094.4 1931.2 1184.5 1627.3 3157.6 1937.8 2253.9 2480.9 3383.2 2051.7 2134.0 1126.5 727.7 1809.1 929.7 637.1 955.2 1525.1 926.4 1559.2 2025.1 810.9 3403.0 1558.6 587.3 182.8 933.3 4267.0 965.1 359.4 419.6 966.2 2438.6 1433.3 1046.5 2560.0 2301.7 3557.2 1973.8 804.4 871.5 2226.3 1344.7 1755.4 1291.4 932.0 675.7 1247.3 3003.7 1622.0 2928.7 3110.3 1170.0 1762.1 1037.2 3720.5 1534.4 3002.3 131.9 836.3 138.6 192.6 466.7 187.9 205.2 254.1 190.4 685.6 142.9 215.8 162.5 100.7 108.4 380.1 140.5 334.0 1261.7 539.0 552.3 586.8 629.9 549.1 561.6 640.0 559.1 636.2 522.3 677.1 530.6 95.9 118.6 88.1 107.7 169.6 565.5 708.9 2065.2 307.9 480.7 157.8 174.7 313.2 87.2 759.4 829.4 369.1 566.1 100.2 358.9 802.2 1395.6 315.0 169.2 77.3 207.7 282.2 44.8 90.2 597.0 1416.7 220.1 138.1 188.0 206.7 144.0 73.2 4.3 750.0 1065.0 97.6 166.8 925.7 297.7 532.9 1763.1 157.2 558.8 355.8 38.4 1255.0 784.1 78.2 53.3 33.4 1213.2 264.5 268.1 209.9 431.4 389.1 208.7 396.9 708.6 124.9 160.9 398.2 43.4 98.6 341.6 389.0 575.7 192.7 157.4 380.7 860.7 PKMYT1 "MYT1, PPP1R126" ENSG00000127564 "Protein kinase, membrane associated tyrosine/threonine 1" Q99640 16 2968024-2980479 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 27.6;testis: 56.9" "Cell type enhanced" "Detected in many" "Erythroid cells: 29.0;Extravillous trophoblasts: 52.0;Plasma cells: 22.9;Spermatocytes: 114.7;Spermatogonia: 46.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in some" "Immune cell enriched" "Detected in single" 6 "T-reg: 1.3" "Lineage enriched" "Detected in single" 6 "T-cells: 1.3" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA068860 Supported "Nucleoplasm,Nucleoli,Golgi apparatus" NA Yes "Cluster 4: T-regs - Cell cycle regulation" "Cluster 23: Testis - Cell cycle regulation" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 12: Non-specific - Cell cycle regulation" "Golgi apparatus" "Nucleoplasm, Nucleoli" "HPA068860: AB_2686050" "unprognostic (7.82e-2)" "unprognostic (8.70e-2)" "unprognostic (5.93e-2)" "unprognostic (2.04e-2)" "unprognostic (4.54e-2)" "unprognostic (1.44e-1)" "prognostic unfavorable (8.33e-4)" "prognostic unfavorable (3.37e-4)" "unprognostic (4.52e-2)" "unprognostic (2.15e-1)" "unprognostic (1.61e-2)" "unprognostic (7.95e-3)" "unprognostic (0.00e+0)" "unprognostic (1.09e-3)" "unprognostic (9.13e-2)" "unprognostic (1.96e-1)" "unprognostic (5.91e-2)" 1.1 1.0 0.4 6.8 0.5 27.6 0.6 1.6 1.4 2.2 0.2 3.9 2.8 0.6 0.3 11.5 0.4 0.6 0.9 0.5 0.2 0.9 1.6 2.0 8.0 0.7 0.6 0.3 1.8 0.1 1.0 3.1 0.8 1.0 1.3 17.4 1.9 0.1 2.4 4.4 4.0 1.0 0.5 5.6 3.3 56.9 0.7 9.6 0.5 0.0 4.5 0.7 3.3 0.8 84.2 57.0 22.0 31.2 0.3 0.9 64.0 65.5 15.1 40.0 38.4 45.0 49.3 54.2 29.2 7.9 24.2 106.7 15.7 20.7 7.2 71.7 56.7 27.9 52.7 40.0 0.0 31.2 73.6 0.7 1.8 24.0 6.5 5.0 8.4 57.6 80.6 87.0 13.5 127.5 83.6 88.0 37.9 39.3 34.4 93.7 51.2 100.7 7.8 17.7 42.6 46.7 31.9 77.7 23.9 12.1 44.7 56.9 7.7 53.2 69.7 77.3 68.0 67.6 54.2 94.0 19.4 40.0 61.2 0.0 0.1 0.1 0.0 0.1 0.0 0.2 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 1.3 0.3 0.4 0.5 1.6 1.4 0.5 0.2 0.7 0.6 0.8 0.5 0.7 0.8 0.0 0.0 1.1 0.0 1.9 2.5 1.3 2.1 0.6 0.4 1.5 1.3 0.6 1.5 1.6 1.8 6.2 16.0 1.3 5.0 0.0 0.8 20.0 0.6 0.8 0.8 1.8 29.0 0.4 0.6 52.0 2.5 3.1 1.9 0.0 4.5 0.0 0.4 11.8 0.0 0.2 3.6 6.1 2.1 1.8 8.6 0.3 1.9 0.0 0.0 0.7 0.2 0.0 0.0 0.3 0.6 0.3 0.4 22.9 0.7 0.3 0.1 0.2 7.1 0.0 0.1 2.6 114.7 46.1 11.2 0.6 7.4 4.2 0.5 8.6 2.0 PKN1 "DBK, MGC46204, PAK1, PKN, PRK1, PRKCL1" ENSG00000123143 "Protein kinase N1" Q16512 19 14433053-14471867 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" "Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "NK-cells: 102.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003982, CAB010278" Approved Approved "Plasma membrane,Cytokinetic bridge" Yes NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 39: Non-specific - Mitochondria" "Cluster 24: NB-4 - Immune response" "Cluster 7: Non-specific - Mitochondria" "Plasma membrane" "Cytokinetic bridge" "CAB010278: AB_2163965, HPA003982: AB_1855440" "unprognostic (3.83e-2)" "unprognostic (2.14e-1)" "unprognostic (4.13e-2)" "unprognostic (1.13e-2)" "unprognostic (1.94e-1)" "unprognostic (4.58e-1)" "unprognostic (1.30e-2)" "unprognostic (1.45e-1)" "unprognostic (1.43e-1)" "unprognostic (8.55e-3)" "unprognostic (4.08e-3)" "unprognostic (2.11e-1)" "unprognostic (1.45e-2)" "unprognostic (1.70e-1)" "unprognostic (8.66e-2)" "unprognostic (4.08e-1)" "unprognostic (2.24e-2)" 59.2 45.1 47.1 40.4 50.3 66.8 49.0 44.6 52.4 46.6 44.2 72.4 14.5 61.0 13.6 16.2 48.7 23.9 89.0 40.9 46.3 43.1 25.0 71.1 49.4 53.6 48.4 38.7 52.5 32.8 44.9 33.3 49.8 43.8 9.3 11.5 41.3 30.6 81.7 20.1 45.2 33.0 49.8 90.4 51.4 50.2 49.2 35.6 39.6 53.8 25.8 60.3 32.8 48.5 152.8 88.9 32.3 67.8 51.3 59.8 53.0 53.5 63.5 55.2 52.5 34.9 84.2 144.4 135.0 92.2 68.9 34.4 52.1 23.8 21.2 117.6 67.7 172.8 55.4 75.2 169.1 68.2 103.9 43.3 17.0 33.5 52.2 62.5 129.8 74.9 78.0 96.7 41.4 62.5 104.1 63.2 59.2 54.7 100.0 138.5 43.9 104.7 27.3 24.2 117.3 166.0 33.2 41.7 88.9 15.5 37.8 117.7 196.6 108.8 46.1 133.2 82.8 126.5 123.6 78.9 71.5 135.7 87.4 27.6 27.9 40.6 30.4 38.5 23.3 15.9 20.5 21.1 26.8 16.9 18.6 21.0 32.6 22.1 52.3 17.0 25.7 29.0 47.1 50.3 44.6 52.4 40.9 46.3 53.6 48.4 49.8 49.8 49.2 48.5 78.1 3.2 2.2 17.3 35.3 3.7 6.4 1.9 1.8 37.2 17.6 14.7 4.0 27.1 3.1 35.0 16.7 2.8 77.9 4.9 1.9 28.2 4.9 27.0 25.4 49.4 40.2 17.7 3.6 30.1 14.5 20.8 30.1 20.7 2.5 80.9 53.2 11.3 59.8 48.8 8.6 10.9 8.2 69.0 17.0 8.4 19.9 56.2 17.8 17.8 48.2 61.2 102.0 7.5 11.9 64.2 10.6 23.0 27.1 12.7 1.1 15.2 12.4 29.2 26.3 21.7 29.2 9.3 42.2 1.3 2.7 3.7 55.5 34.3 4.8 4.9 PKN2 "Pak-2, PRK2, PRKCL2, STK7" ENSG00000065243 "Protein kinase N2" Q16513 1 88684222-88836255 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Cell adhesion, Cell cycle, Cell division, Cilium biogenesis/degradation, Host-virus interaction, Transcription, Transcription regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 5 "neutrophil: 80.5" "Lineage enriched" "Detected in all" 8 "granulocytes: 80.5" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034861, HPA057913" Approved Supported "Nucleoplasm,Nuclear bodies,Plasma membrane,Intermediate filaments,Centrosome,Cytosol" Yes No "Cluster 1: Neutrophils - Mixed function" "Cluster 34: Non-specific - Transcription" "Cluster 15: RT4 - Unknown function" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Intermediate filaments" "Nuclear bodies, Plasma membrane, Centrosome, Cytosol" "HPA034861: AB_2674363, HPA057913: AB_2732617" "unprognostic (7.52e-2)" "unprognostic (1.46e-1)" "prognostic favorable (5.67e-4)" "unprognostic (5.95e-2)" "unprognostic (3.39e-2)" "unprognostic (2.51e-2)" "unprognostic (4.64e-3)" "unprognostic (1.38e-1)" "unprognostic (4.43e-2)" "unprognostic (1.27e-2)" "unprognostic (2.90e-3)" "unprognostic (1.23e-1)" "unprognostic (1.51e-2)" "unprognostic (5.98e-2)" "unprognostic (2.38e-1)" "unprognostic (1.01e-2)" "unprognostic (1.99e-1)" 19.3 16.5 9.3 17.6 14.2 48.7 24.1 20.7 10.9 16.4 17.0 23.9 30.5 23.6 25.0 24.7 18.1 17.1 14.1 9.5 9.7 16.9 20.5 20.4 18.2 12.3 10.4 31.2 15.5 22.3 10.1 24.7 12.7 20.3 30.0 26.7 16.3 15.4 9.8 20.3 30.8 18.5 10.1 19.0 20.9 10.5 12.6 17.8 26.1 13.4 17.4 21.3 15.4 17.6 61.1 23.8 45.2 27.3 29.8 33.6 29.6 35.3 32.2 38.5 39.8 25.3 42.5 23.9 41.0 33.6 47.3 46.7 44.7 26.6 52.4 8.6 33.0 17.7 49.3 21.4 26.2 17.6 5.1 27.7 27.1 30.2 36.3 30.6 44.7 18.6 29.9 16.8 42.2 12.2 20.5 15.2 22.8 23.1 27.1 19.3 68.8 9.8 34.3 117.9 22.0 14.5 52.7 29.8 45.7 33.9 22.5 15.7 42.2 32.5 29.2 42.1 37.2 9.2 8.6 16.6 13.6 17.1 12.6 15.3 9.9 16.6 5.7 5.9 5.1 8.0 5.1 5.3 5.0 9.3 6.6 5.6 80.5 3.5 8.0 8.6 4.6 2.7 9.3 14.2 20.7 10.9 9.5 9.7 12.3 10.4 12.7 10.1 12.6 17.6 104.7 41.7 57.8 102.5 52.5 48.4 44.3 33.3 75.1 85.4 60.2 67.9 50.8 38.6 47.9 69.9 89.6 42.9 48.1 101.5 11.7 61.2 2.6 63.7 68.7 59.5 44.3 57.7 134.2 60.7 33.1 53.1 85.6 84.6 15.8 107.0 47.5 39.4 24.2 65.6 130.8 64.3 32.6 35.8 27.9 6.6 54.3 44.9 32.0 178.0 57.3 50.5 22.6 117.1 146.4 77.6 98.1 48.2 54.8 64.7 84.0 26.7 49.1 150.5 39.5 62.8 55.5 43.6 34.6 83.0 52.4 37.4 44.8 90.2 65.0 124.2 PKN3 "PKNbeta, UTDP4-1" ENSG00000160447 "Protein kinase N3" Q6P5Z2 9 128702503-128720916 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Adipocytes: 27.1;Breast glandular cells: 15.3;Endothelial cells: 17.9;Microglial cells: 13.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HeLa: 78.0;REH: 42.4" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA045390, HPA058305" Uncertain Approved Vesicles NA NA "Cluster 35: T-regs - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 20: HeLa - Mitochondria" "Cluster 30: Mammary glandular cells - Lactation" Vesicles "HPA045390: AB_2679308, HPA058305: AB_2683674" "unprognostic (4.36e-2)" "unprognostic (5.70e-2)" "unprognostic (2.68e-2)" "unprognostic (7.62e-2)" "unprognostic (2.23e-1)" "unprognostic (2.65e-2)" "unprognostic (6.10e-2)" "unprognostic (8.04e-2)" "unprognostic (1.78e-1)" "unprognostic (3.68e-1)" "unprognostic (1.48e-1)" "unprognostic (7.91e-2)" "unprognostic (8.73e-3)" "unprognostic (6.18e-3)" "unprognostic (9.99e-2)" "unprognostic (7.23e-2)" "unprognostic (2.36e-1)" 12.6 2.7 6.1 2.6 5.8 2.6 13.2 7.3 6.8 6.3 4.7 5.1 4.7 7.6 0.6 5.2 7.0 2.3 15.9 5.0 5.2 9.0 4.1 11.1 2.1 6.1 5.9 2.8 5.3 2.2 1.8 3.3 6.0 5.4 0.9 0.1 11.5 2.0 3.6 5.4 6.2 2.8 5.4 9.5 7.0 2.6 7.2 2.8 6.9 3.4 1.1 6.9 6.3 5.3 2.9 14.1 11.3 17.2 0.1 0.3 27.7 8.7 2.7 12.6 13.0 0.1 10.1 0.1 8.4 4.7 2.6 19.0 13.8 2.1 2.9 9.0 26.0 17.1 78.0 20.5 2.1 2.1 3.0 0.6 0.7 6.8 1.9 2.7 25.1 5.0 39.6 1.9 2.3 26.9 2.6 9.2 10.5 13.1 4.1 42.4 21.3 3.8 5.3 1.7 1.9 8.5 6.6 3.5 6.5 6.1 12.3 13.6 21.9 0.1 10.3 20.0 6.7 6.2 2.9 5.7 1.6 2.2 8.0 0.0 0.0 0.3 0.1 0.1 0.3 0.0 0.1 0.1 0.2 0.0 0.1 0.0 0.4 0.2 0.0 0.0 0.2 0.0 6.1 5.8 7.3 6.8 5.0 5.2 6.1 5.9 6.0 5.4 7.2 5.3 27.1 0.0 2.0 0.3 1.2 1.0 1.7 1.7 3.4 0.2 15.3 3.6 1.8 4.3 2.1 0.0 0.0 2.2 2.0 1.5 0.0 1.9 0.2 2.2 1.1 17.9 0.0 5.0 0.3 2.6 6.1 1.8 5.1 4.9 0.0 5.0 9.3 0.4 1.9 0.0 0.2 1.7 0.0 0.8 2.3 0.9 1.5 0.8 0.0 13.1 1.2 0.3 4.1 0.0 0.1 3.3 1.5 0.7 1.6 1.1 2.6 0.6 0.5 0.2 0.0 0.7 1.3 2.8 6.6 2.8 1.0 1.4 1.9 1.4 2.5 1.7 PLK1 PLK ENSG00000166851 "Polo like kinase 1" P53350 16 23677656-23690367 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 32.0;lymphoid tissue: 43.9;testis: 33.1" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 32.3;Early spermatids: 123.7;Erythroid cells: 38.3;Extravillous trophoblasts: 55.9;Spermatocytes: 79.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 5 "T-reg: 5.6" "Lineage enriched" "Detected in many" 5 "T-cells: 5.6" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" "HPA051638, HPA053229" Approved NA Yes "Cluster 4: T-regs - Cell cycle regulation" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" "HPA051638: AB_2681561, HPA053229: AB_2682084" "unprognostic (7.21e-3)" "unprognostic (1.77e-1)" "unprognostic (1.98e-3)" "unprognostic (4.97e-3)" "unprognostic (9.56e-2)" "unprognostic (5.12e-2)" "prognostic unfavorable (2.70e-7)" "prognostic unfavorable (2.28e-5)" "unprognostic (2.55e-2)" "unprognostic (1.89e-1)" "prognostic unfavorable (4.12e-4)" "unprognostic (1.24e-2)" "prognostic unfavorable (0.00e+0)" "unprognostic (1.33e-1)" "unprognostic (8.10e-2)" "unprognostic (1.19e-1)" "unprognostic (1.26e-2)" 1.4 1.5 2.3 13.4 2.3 32.0 1.5 2.5 3.2 2.3 2.0 9.6 10.4 1.2 0.4 13.9 1.0 1.4 1.0 2.3 2.1 1.4 1.9 1.9 27.8 2.3 2.3 1.3 1.1 0.2 1.2 6.4 2.2 1.2 10.1 1.2 2.4 0.3 1.0 5.7 9.2 4.0 2.0 9.1 6.2 33.1 2.5 43.9 0.9 0.4 30.0 2.8 4.0 2.8 199.9 207.5 166.2 90.9 5.2 11.7 92.8 111.0 74.5 172.5 127.0 184.3 131.0 99.1 56.3 76.5 90.1 112.8 229.5 93.5 206.1 139.5 128.0 125.2 163.4 257.1 1.7 147.5 133.7 4.8 5.2 124.7 125.2 21.6 127.9 127.5 200.7 133.9 134.8 187.8 139.8 151.4 189.5 82.1 103.5 217.2 111.7 160.0 49.3 43.9 94.3 65.3 126.8 88.9 55.8 94.4 114.4 92.1 65.1 82.7 102.7 79.9 194.1 93.2 156.8 173.6 69.3 127.7 137.2 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.8 0.3 0.3 0.0 0.0 0.0 0.4 0.9 0.0 0.0 5.6 1.4 2.3 2.3 2.5 3.2 2.3 2.1 2.3 2.3 2.2 2.0 2.5 2.8 0.6 3.2 0.0 3.3 7.6 1.3 1.2 6.5 0.0 1.4 1.7 2.3 0.6 0.0 1.4 0.0 4.2 32.3 0.4 5.5 0.0 0.8 123.7 3.4 1.3 2.5 0.0 38.3 3.1 0.8 55.9 4.7 10.2 1.8 1.3 19.9 3.3 1.1 20.8 0.0 2.3 7.3 4.1 6.9 3.2 13.9 1.2 7.2 0.0 2.8 0.4 1.1 0.0 1.5 2.3 1.2 0.3 0.7 23.0 2.0 1.5 0.1 1.3 1.3 0.0 2.3 6.1 79.5 13.5 12.2 1.8 3.8 2.5 1.2 17.9 2.0 PLK2 SNK ENSG00000145632 "Polo like kinase 2" Q9NYY3 5 58453982-58460139 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 380.7;Extravillous trophoblasts: 257.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 4 "NK-cell: 9.1" "Lineage enriched" "Detected in many" 4 "NK-cells: 9.1" "Cell line enhanced" "Detected in many" "hTERT-RPE1: 1060.6;T-47d: 396.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009624, HPA069329" Approved Approved Nucleoplasm,Mitochondria,Cytosol NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 7: Non-specific - Mitochondria" "Nucleoplasm, Mitochondria, Cytosol" "CAB009624: AB_2167745, HPA069329: " "unprognostic (4.82e-2)" "unprognostic (1.08e-2)" "unprognostic (2.38e-1)" "unprognostic (6.51e-2)" "prognostic unfavorable (7.75e-4)" "unprognostic (1.22e-1)" "unprognostic (2.55e-2)" "unprognostic (1.03e-2)" "unprognostic (2.44e-2)" "unprognostic (1.06e-2)" "unprognostic (1.01e-1)" "unprognostic (3.11e-1)" "prognostic unfavorable (2.08e-4)" "unprognostic (6.56e-2)" "unprognostic (1.43e-1)" "unprognostic (3.46e-1)" "unprognostic (1.95e-3)" 24.3 8.4 25.6 7.4 35.7 9.3 40.6 6.4 31.2 37.9 16.4 11.8 9.3 29.0 9.3 35.5 21.0 32.1 54.7 44.4 10.4 15.7 31.1 32.3 7.2 8.1 12.3 19.3 23.4 5.9 6.3 47.6 8.4 17.7 14.6 2.1 42.9 10.5 7.4 47.3 12.9 26.6 7.3 83.6 10.4 38.1 11.8 7.2 18.0 13.6 7.6 29.8 32.1 16.8 131.1 115.6 38.3 3.1 19.9 31.9 15.1 27.1 44.8 86.3 49.8 8.6 112.1 0.0 176.3 95.2 208.3 159.8 1.7 61.5 75.6 0.3 3.5 0.0 50.8 9.7 106.1 0.6 3.6 18.7 82.0 33.3 90.9 1060.6 175.4 0.0 0.1 4.4 169.8 47.5 0.3 0.2 7.6 12.4 18.5 6.3 106.5 0.0 221.6 25.4 2.3 5.1 82.4 16.0 76.0 66.1 396.9 2.0 231.9 24.3 63.8 11.0 217.8 0.1 0.3 0.3 18.8 0.3 110.7 2.2 0.5 1.9 0.1 1.2 0.0 0.8 0.5 0.0 2.2 0.6 0.9 0.4 1.5 9.1 0.5 1.5 0.4 0.4 25.6 35.7 6.4 31.2 44.4 10.4 8.1 12.3 8.4 7.3 11.8 16.8 144.6 19.2 15.8 5.9 23.4 141.7 194.1 116.1 380.7 3.8 108.5 203.7 128.9 30.0 134.9 18.4 4.2 66.5 22.7 66.3 9.8 109.8 10.9 132.7 67.8 178.7 84.3 2.7 44.3 77.9 257.3 107.8 136.6 165.4 9.5 4.1 89.3 7.7 14.9 0.0 22.8 39.9 124.1 8.1 19.3 5.0 12.8 39.5 24.9 15.9 3.2 3.3 0.0 3.5 4.9 103.2 44.6 10.9 8.2 76.1 38.5 5.5 31.6 2.9 0.0 74.0 106.6 65.1 10.4 184.9 103.4 129.8 21.2 7.4 45.6 63.1 PLK3 "CNK, FNK, PRK" ENSG00000173846 "Polo like kinase 3" Q9H4B4 1 44800377-44805990 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle, DNA damage" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Paneth cells: 116.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA060318 Enhanced NA NA "Cluster 35: T-regs - Unknown function" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 7: Non-specific - Mitochondria" "HPA060318: AB_2684252" "unprognostic (1.06e-1)" "unprognostic (8.71e-2)" "unprognostic (3.69e-2)" "unprognostic (3.51e-3)" "unprognostic (3.09e-2)" "unprognostic (4.72e-2)" "unprognostic (1.02e-1)" "unprognostic (1.59e-1)" "unprognostic (5.12e-3)" "unprognostic (6.78e-2)" "unprognostic (7.67e-3)" "unprognostic (2.79e-2)" "prognostic unfavorable (1.75e-4)" "unprognostic (2.04e-1)" "unprognostic (1.43e-1)" "unprognostic (5.06e-2)" "unprognostic (1.35e-1)" 13.6 6.4 3.2 10.7 3.6 13.8 8.9 4.0 5.3 8.7 8.1 4.9 3.3 8.1 2.8 19.2 7.4 17.3 6.3 3.6 6.0 5.8 7.1 12.9 9.0 9.3 7.1 6.6 8.9 7.1 7.5 6.7 6.7 5.6 2.9 0.4 6.7 3.3 2.8 16.1 6.5 4.9 5.8 7.7 5.4 2.1 5.4 5.4 7.3 2.4 5.8 18.0 8.7 7.2 7.2 4.1 6.6 3.4 4.7 15.0 12.3 15.7 20.8 5.9 5.8 2.5 9.9 8.1 6.5 12.9 18.7 6.5 3.7 21.4 3.2 13.5 0.7 9.1 2.6 6.2 22.5 2.9 11.7 11.8 12.3 17.4 16.1 20.0 17.8 3.0 4.9 3.6 13.0 4.6 6.2 2.7 4.5 4.0 5.5 7.8 4.3 13.3 20.3 2.4 5.0 3.2 4.5 8.3 17.6 10.1 0.6 2.8 23.3 3.6 9.4 7.5 9.7 9.5 4.7 2.8 8.0 5.2 7.2 0.0 4.0 1.0 1.9 5.9 2.1 1.4 11.6 4.7 5.0 1.2 12.4 5.8 4.7 0.8 6.3 2.0 14.0 4.4 3.2 3.6 4.0 5.3 3.6 6.0 9.3 7.1 6.7 5.8 5.4 7.2 55.7 12.8 35.1 1.3 32.2 44.1 60.5 23.3 32.5 7.1 58.4 33.7 3.4 32.9 15.8 5.5 2.1 19.0 32.2 77.7 0.0 18.3 0.8 41.9 27.6 43.5 53.0 2.7 3.6 13.0 22.9 36.7 109.6 67.5 78.7 12.0 32.5 6.7 36.9 6.7 6.3 53.0 2.0 37.7 60.3 0.7 9.9 72.5 12.4 10.3 9.8 7.4 1.0 1.5 2.0 24.3 116.8 5.3 31.4 25.8 47.3 3.3 14.7 10.2 26.3 58.5 30.5 2.5 4.5 37.2 33.5 59.2 65.2 17.0 46.3 58.9 PLK4 "Sak, STK18" ENSG00000142731 "Polo like kinase 4" O00444 4 127880893-127899224 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" Dwarfism "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "bone marrow: 22.6;lymphoid tissue: 14.4;testis: 22.6" "Cell type enhanced" "Detected in many" "Early spermatids: 65.9;Late spermatids: 87.5;Spermatocytes: 53.5" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017327, HPA035026, HPA043198" Approved Supported Centrosome,Cytosol NA NA "Cluster 35: T-regs - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" "Centrosome, Cytosol" "HPA017327: AB_2669584, HPA035026: AB_10602080, HPA043198: AB_2732504" "unprognostic (2.44e-1)" "unprognostic (4.24e-2)" "prognostic favorable (7.46e-5)" "unprognostic (2.18e-1)" "unprognostic (3.79e-1)" "unprognostic (9.20e-2)" "unprognostic (1.06e-5)" "prognostic unfavorable (5.13e-4)" "unprognostic (1.44e-3)" "unprognostic (5.66e-2)" "prognostic unfavorable (5.14e-4)" "unprognostic (1.27e-1)" "unprognostic (2.22e-11)" "unprognostic (2.29e-2)" "unprognostic (3.58e-1)" "unprognostic (4.75e-2)" "unprognostic (7.93e-2)" 1.0 1.1 0.4 4.9 0.5 22.6 2.0 0.2 0.7 0.9 0.1 3.5 2.8 1.5 0.6 3.2 1.3 1.1 0.5 0.5 0.6 0.6 0.8 0.9 7.4 0.5 0.5 1.0 0.4 0.6 0.2 3.6 0.4 0.9 4.3 2.1 0.9 0.9 0.1 2.3 2.9 1.8 0.4 1.6 2.0 22.6 0.6 14.4 0.9 0.7 7.3 1.3 1.4 0.4 26.1 12.1 44.3 22.9 1.5 4.2 20.1 24.9 17.6 32.4 33.3 17.0 26.1 34.9 9.0 13.9 26.3 16.7 31.6 19.9 49.6 27.4 13.1 31.6 20.0 16.0 0.5 45.2 35.9 1.4 2.0 29.7 13.6 5.9 25.3 26.3 37.5 45.2 27.6 18.2 69.9 20.1 20.7 26.3 13.6 36.0 30.9 12.1 10.8 16.4 24.4 20.0 15.8 14.2 7.6 18.7 11.5 19.3 11.0 25.3 24.4 17.4 31.4 23.1 27.4 49.0 13.0 33.7 28.7 0.0 0.1 0.4 0.4 0.2 0.3 0.1 0.5 0.5 0.2 0.2 0.1 0.6 0.0 0.4 0.1 0.1 1.2 0.2 0.4 0.5 0.2 0.7 0.5 0.6 0.5 0.5 0.4 0.4 0.6 0.4 1.6 0.0 0.6 0.0 1.6 1.7 0.9 1.7 1.2 1.8 1.0 0.9 0.9 0.0 0.6 1.8 0.0 6.0 1.9 2.0 0.0 0.6 65.9 4.7 1.0 1.0 2.4 19.6 0.8 0.4 12.9 1.6 4.1 2.0 1.3 7.5 0.4 0.5 3.7 0.0 0.8 3.3 6.1 1.3 0.6 87.5 2.8 1.5 0.0 1.0 1.2 1.1 1.0 1.0 1.2 0.1 0.5 0.4 8.7 0.7 0.5 0.6 3.7 0.8 0.0 0.4 3.6 53.5 13.4 6.8 0.9 3.8 2.1 0.8 4.5 1.7 PLOD3 LH3 ENSG00000106397 "Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3" O60568 7 101205977-101218420 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Dioxygenase, Glycosyltransferase, Multifunctional enzyme, Oxidoreductase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Cancer enhanced" "Detected in all" "melanoma: 115.2" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in all" 4 "dendritic cells: 20.3;monocytes: 22.5;T-cells: 12.6" "Cell line enhanced" "Detected in all" "Karpas-707: 695.6;WM-115: 680.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001236 Uncertain "Secreted to extracellular matrix" NA NA 1600000 "Cluster 39: Non-specific - mRNA processing" "Cluster 15: Liver - Metabolism" "Cluster 2: Karpas-707 - Immune response" "Cluster 38: Extravillous trophoblasts - Unknown function" "HPA001236: AB_1855474" "unprognostic (1.15e-1)" "prognostic unfavorable (1.91e-5)" "prognostic unfavorable (3.26e-4)" "unprognostic (1.39e-1)" "unprognostic (2.76e-3)" "unprognostic (1.04e-2)" "unprognostic (6.26e-3)" "unprognostic (1.11e-3)" "unprognostic (8.00e-3)" "unprognostic (1.18e-2)" "unprognostic (4.18e-2)" "unprognostic (1.66e-1)" "unprognostic (1.21e-3)" "unprognostic (1.68e-1)" "unprognostic (1.54e-1)" "unprognostic (8.52e-3)" "unprognostic (9.87e-2)" 41.9 27.3 43.6 22.9 53.2 19.6 32.8 54.9 58.5 33.3 46.8 37.8 25.7 38.9 11.7 12.2 32.5 18.8 42.6 43.6 46.3 36.3 54.1 37.5 14.6 61.1 52.3 26.3 41.8 21.5 27.1 35.0 58.9 24.2 15.3 3.9 19.4 18.6 15.3 19.1 35.9 26.0 49.4 35.3 30.0 12.9 51.7 8.0 25.3 11.8 7.5 35.2 25.2 71.9 71.7 62.4 27.1 168.2 116.2 83.9 51.4 125.5 135.9 122.7 88.6 98.0 89.0 5.6 140.2 211.4 100.7 83.0 50.0 72.0 31.2 37.8 23.8 7.2 70.7 97.3 157.6 31.5 57.4 90.8 67.6 71.6 55.4 120.2 110.9 4.6 68.4 695.6 84.2 194.5 3.4 72.1 53.5 120.5 94.9 21.8 35.1 108.3 42.0 19.1 21.2 116.0 81.1 116.2 288.1 66.8 21.9 105.2 100.5 188.1 94.9 228.1 155.0 38.5 75.9 5.2 112.4 74.2 680.2 0.0 18.1 4.4 12.6 21.8 10.9 3.7 9.3 8.3 16.5 2.2 4.1 4.5 1.8 3.6 22.5 20.3 6.7 9.5 43.6 53.2 54.9 58.5 43.6 46.3 61.1 52.3 58.9 49.4 51.7 71.9 34.1 22.4 8.7 11.1 9.7 8.9 10.8 18.9 8.0 5.7 8.1 9.1 16.1 21.5 8.7 25.8 14.6 20.4 22.0 37.6 1.9 40.2 0.6 10.8 29.9 28.5 16.2 19.1 11.9 31.6 71.6 34.2 17.9 20.5 19.7 25.9 26.7 18.3 50.1 8.4 10.8 18.0 4.1 23.3 18.3 2.1 26.1 23.2 62.2 4.7 18.9 7.7 12.3 10.1 33.4 36.1 37.8 14.7 19.7 8.0 45.8 8.8 9.3 7.3 19.7 14.3 29.8 8.9 12.4 1.9 4.8 18.9 12.5 18.4 27.3 5.2 PMVK "HUMPMKI, PMK, PMKA" ENSG00000163344 "Phosphomevalonate kinase" Q15126 1 154924740-154936719 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cholesterol biosynthesis, Cholesterol metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism" "Kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal tubular cells: 266.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA029900 Approved NA NA 15000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Mitochondria" "Cluster 2: Karpas-707 - Immune response" "Cluster 47: Cytotrophoblasts - Unknown function" "HPA029900: AB_10601390" "unprognostic (2.52e-1)" "unprognostic (3.68e-2)" "unprognostic (1.25e-2)" "unprognostic (1.32e-1)" "unprognostic (2.31e-1)" "unprognostic (1.81e-2)" "unprognostic (8.13e-2)" "unprognostic (5.47e-2)" "unprognostic (8.22e-2)" "prognostic favorable (9.70e-4)" "unprognostic (1.41e-1)" "unprognostic (8.76e-2)" "prognostic favorable (4.96e-4)" "unprognostic (2.07e-1)" "unprognostic (1.67e-1)" "unprognostic (1.78e-1)" "unprognostic (2.10e-1)" 39.9 56.4 99.0 29.8 100.1 15.3 35.0 97.9 108.9 33.4 95.0 39.9 45.9 25.9 17.7 77.7 37.2 17.2 63.1 93.9 96.4 53.8 91.9 30.1 34.6 98.6 97.4 35.8 41.6 58.2 60.3 23.7 96.0 32.4 22.2 19.8 34.0 27.1 79.1 69.2 44.2 27.7 96.4 45.7 40.5 26.6 102.3 27.9 31.5 47.4 36.8 31.9 37.9 99.8 51.8 72.9 46.7 72.5 43.6 30.9 48.5 40.5 29.3 38.9 37.0 30.6 101.0 75.1 75.9 49.3 40.5 49.4 65.3 63.9 17.8 103.3 28.9 34.1 104.1 29.0 40.0 51.4 29.3 36.3 58.7 70.2 49.6 19.5 40.0 65.9 36.8 221.7 41.3 108.3 40.8 51.0 41.0 121.7 95.0 60.3 29.8 171.1 66.1 38.4 37.7 91.1 44.1 75.7 51.9 35.0 146.7 91.1 32.7 35.8 29.2 84.4 62.1 174.0 153.2 131.8 58.9 83.9 46.7 28.0 80.9 91.8 68.2 205.6 110.1 114.8 93.1 70.6 93.6 111.1 59.1 59.1 6.9 59.7 219.4 96.5 134.3 80.0 99.0 100.1 97.9 108.9 93.9 96.4 98.6 97.4 96.0 96.4 102.3 99.8 22.7 57.7 37.5 9.4 42.2 69.8 105.9 95.8 51.8 38.5 67.1 68.3 57.3 78.6 42.2 53.3 8.4 235.7 31.5 65.0 266.1 69.6 9.0 45.0 28.5 29.8 66.4 35.6 5.1 71.3 108.1 45.1 46.9 44.2 22.2 49.8 39.3 146.9 141.0 37.0 7.0 78.9 67.1 67.9 49.5 13.5 42.6 47.8 65.8 3.7 49.5 119.1 41.2 8.0 11.8 61.7 61.7 47.8 58.8 53.7 219.3 246.1 22.1 27.4 32.9 46.0 48.4 51.3 51.3 81.0 90.5 227.7 45.1 162.6 79.9 76.2 PNCK "CaMK1b, MGC45419" ENSG00000130822 "Pregnancy up-regulated nonubiquitous CaM kinase" Q6P2M8 X 153669733-153689010 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 65.1;intestine: 81.7" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 40.9;Excitatory neurons: 29.0;Extravillous trophoblasts: 63.9;Granulosa cells: 46.9;Syncytiotrophoblasts: 49.5" "Cancer enhanced" "Detected in many" "renal cancer: 15.3" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 9 "AN3-CA: 33.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007458 Approved Approved "Golgi apparatus,Plasma membrane,Cytosol" NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 40: Granulosa cells - Unknown function" "Plasma membrane" "Golgi apparatus, Cytosol" "HPA007458: AB_1079644" "unprognostic (1.56e-1)" "unprognostic (2.56e-1)" "unprognostic (1.16e-2)" "unprognostic (5.95e-3)" "unprognostic (1.83e-2)" "unprognostic (3.98e-2)" "unprognostic (2.15e-4)" "unprognostic (1.72e-1)" "unprognostic (1.08e-1)" "unprognostic (1.46e-2)" "unprognostic (3.60e-1)" "unprognostic (1.27e-1)" "prognostic unfavorable (1.04e-6)" "unprognostic (2.86e-3)" "unprognostic (1.43e-1)" "unprognostic (2.66e-1)" "unprognostic (6.26e-3)" 1.6 1.2 43.7 1.9 48.8 0.0 0.6 6.5 53.3 1.3 4.8 81.7 3.4 6.5 1.7 14.0 4.1 2.6 6.5 49.8 40.8 1.9 0.2 0.6 0.0 19.6 22.8 0.9 0.3 0.5 1.8 2.0 21.1 17.2 3.8 7.9 0.4 37.6 2.0 1.8 13.4 15.7 15.0 0.2 15.9 8.8 65.1 1.4 0.3 0.3 0.1 27.4 2.2 28.5 0.3 0.1 0.4 33.9 0.0 0.0 3.4 0.3 0.3 0.0 0.0 0.0 0.2 0.0 1.0 0.0 0.2 0.4 0.5 0.0 0.0 0.0 3.9 0.0 0.0 0.5 0.2 0.0 0.1 0.1 0.0 0.0 0.0 1.6 0.0 0.3 0.4 0.3 0.2 0.7 0.0 0.0 0.9 0.3 0.0 0.0 0.0 0.0 0.1 0.1 0.2 3.7 0.0 0.1 2.7 0.9 0.3 0.4 0.0 0.2 1.2 0.0 0.2 0.2 0.0 0.2 0.5 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 43.7 48.8 6.5 53.3 49.8 40.8 19.6 22.8 21.1 15.0 65.1 28.5 0.0 0.0 0.0 18.9 0.0 0.6 0.4 40.9 0.0 21.6 0.3 0.9 3.0 0.0 18.0 0.0 22.9 13.5 0.1 1.7 0.0 0.4 0.3 0.3 4.4 0.3 0.0 0.0 29.0 0.4 63.9 0.5 0.0 0.3 0.0 46.9 0.0 0.0 2.4 0.0 24.2 1.1 12.2 0.0 0.0 0.8 0.0 0.3 1.8 1.0 0.0 3.2 0.0 11.1 13.2 2.9 0.1 0.4 0.0 0.3 20.3 0.4 2.6 19.4 0.0 0.0 4.0 0.6 0.9 0.0 0.6 49.5 0.1 0.6 0.4 1.0 PNKP PNK ENSG00000039650 "Polynucleotide kinase 3'-phosphatase" Q96T60 19 49859882-49878351 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair" "Hydrolase, Kinase, Multifunctional enzyme, Transferase" "Disease variant, Epilepsy, Mental retardation, Neurodegeneration, Primary microcephaly" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006782 Supported Supported Nucleoplasm,Nucleoli NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 18: Non-specific - Mitochondria" "Cluster 15: RT4 - Unknown function" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Nucleoli" "HPA006782: AB_1855496" "prognostic favorable (9.18e-4)" "unprognostic (1.87e-1)" "unprognostic (4.31e-2)" "unprognostic (4.23e-1)" "unprognostic (1.00e-1)" "unprognostic (4.40e-2)" "unprognostic (1.08e-2)" "unprognostic (1.24e-1)" "unprognostic (3.36e-1)" "unprognostic (1.58e-1)" "unprognostic (3.71e-2)" "unprognostic (1.70e-1)" "unprognostic (4.55e-2)" "unprognostic (3.00e-2)" "unprognostic (2.82e-1)" "unprognostic (7.24e-2)" "unprognostic (3.68e-3)" 18.9 45.1 12.0 21.0 12.9 26.4 21.2 12.8 16.2 21.1 24.2 21.6 16.0 21.3 13.5 19.4 22.9 10.6 23.9 14.4 11.9 27.3 22.4 22.2 17.5 14.0 14.0 23.7 28.6 16.7 36.8 11.1 14.3 25.3 13.1 10.1 21.6 12.4 18.5 17.8 22.8 11.5 12.8 37.2 25.0 21.2 13.3 12.3 31.9 7.8 15.3 19.4 18.0 14.1 27.5 17.4 19.1 27.2 15.8 13.4 28.6 43.4 21.2 18.7 17.7 17.5 34.2 18.4 13.6 13.6 11.3 23.5 6.1 25.9 10.9 22.3 27.2 30.0 36.7 14.8 12.2 25.8 36.3 13.2 13.0 17.9 11.0 16.9 26.3 23.4 14.9 34.3 24.7 18.8 28.7 23.5 16.0 28.3 37.4 24.3 15.9 34.7 21.0 68.5 20.6 33.4 19.3 52.5 9.2 14.5 10.2 14.8 36.0 37.6 24.9 9.6 35.8 38.7 16.5 13.0 33.8 12.3 30.8 1.8 12.3 16.7 9.2 11.5 7.9 9.1 7.8 7.3 9.8 12.2 5.7 5.0 23.4 3.9 18.1 5.5 9.1 5.8 12.0 12.9 12.8 16.2 14.4 11.9 14.0 14.0 14.3 12.8 13.3 14.1 23.6 16.0 23.6 5.9 47.2 13.4 35.4 29.9 25.6 40.9 28.1 23.7 11.1 21.5 19.1 20.2 81.3 44.5 37.7 40.0 23.5 42.5 15.0 25.2 28.5 26.6 30.5 17.1 6.0 39.9 35.1 19.1 31.6 28.0 29.1 54.6 35.0 20.1 39.5 33.7 6.0 31.7 24.4 27.7 19.0 32.9 59.4 26.8 14.2 8.4 46.1 18.4 96.8 6.0 5.7 44.6 22.3 44.8 40.4 33.6 27.1 36.1 33.8 73.9 19.7 17.9 20.1 19.4 28.9 23.3 13.1 49.3 39.2 83.0 34.1 35.6 PNMT PENT ENSG00000141744 "Phenylethanolamine N-methyltransferase" P11086 17 39667981-39670475 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Catecholamine biosynthesis" "Methyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "adrenal gland: 158.3" "Cell type enhanced" "Detected in many" "Breast glandular cells: 20.1;Breast myoepithelial cells: 15.1;Cardiomyocytes: 13.4;Endometrial ciliated cells: 24.0;Erythroid cells: 16.6;Hepatic stellate cells: 27.5;Skeletal myocytes: 48.0" "Group enriched" "Detected in many" 5 "breast cancer: 7.7;cervical cancer: 27.0;urothelial cancer: 9.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HEL: 5.3;K-562: 12.8;NB-4: 24.1;NTERA-2: 4.5;SCLC-21H: 6.4;SH-SY5Y: 5.8" "Region enhanced" "Detected in single" "basal ganglia: 1.4" "Not detected" "Not detected" "CAB017029, HPA043412, HPA051005" Enhanced NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 17: Adrenal gland - Steroid metabolism" "Cluster 24: NB-4 - Immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "CAB017029: , HPA043412: AB_2630373, HPA051005: AB_2681306" "unprognostic (1.50e-1)" "unprognostic (3.74e-2)" "unprognostic (1.08e-1)" "prognostic unfavorable (3.95e-5)" "unprognostic (4.27e-2)" "unprognostic (3.02e-1)" "unprognostic (2.98e-2)" "unprognostic (5.75e-2)" "unprognostic (5.29e-2)" "unprognostic (1.30e-1)" "unprognostic (1.51e-1)" "unprognostic (1.33e-1)" "unprognostic (1.52e-4)" "unprognostic (1.58e-1)" "unprognostic (1.97e-1)" "unprognostic (4.72e-2)" "unprognostic (1.87e-2)" 5.3 158.3 15.9 0.2 28.9 2.1 8.4 17.3 16.3 7.6 7.4 4.2 0.5 4.4 1.4 3.0 9.0 0.3 22.6 9.9 17.0 3.7 0.5 8.9 0.3 17.3 22.7 3.0 1.7 7.4 30.7 3.2 20.0 8.5 0.0 0.1 3.2 21.3 21.1 3.1 7.2 0.2 10.8 2.1 6.9 4.5 25.7 0.1 1.8 17.5 0.0 6.5 5.9 11.7 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.2 0.6 0.2 0.0 0.0 0.1 0.1 0.0 0.0 0.0 1.9 5.3 0.2 0.4 2.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 12.8 0.0 0.0 0.0 0.0 24.1 4.5 0.5 0.1 0.1 0.0 0.3 0.0 0.0 6.4 5.8 0.1 2.3 0.2 0.1 0.3 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.4 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 15.9 28.9 17.3 16.3 9.9 17.0 17.3 22.7 20.0 10.8 25.7 11.7 3.1 0.0 0.0 1.0 0.5 0.5 0.7 0.0 0.0 0.3 20.1 15.1 13.4 1.5 0.0 5.5 0.0 0.1 1.1 0.1 1.9 0.0 0.7 24.0 2.6 5.0 3.0 16.6 0.5 0.0 0.9 1.1 0.0 9.0 0.0 0.7 27.5 0.0 0.1 0.0 0.1 0.2 0.0 0.0 0.0 1.5 2.1 0.2 0.0 1.0 0.0 3.5 0.0 0.0 0.0 0.1 0.0 0.4 0.3 0.2 0.1 0.1 0.0 0.5 0.0 48.0 0.8 1.0 2.3 0.0 0.4 0.0 11.0 0.0 0.3 1.8 PNP "NP, PUNP" ENSG00000198805 "Purine nucleoside phosphorylase" P00491 14 20468954-20477089 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Purine salvage" "Glycosyltransferase, Transferase" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 333.9;epididymis: 594.8" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 360.6;Erythroid cells: 227.3;Syncytiotrophoblasts: 646.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HL-60: 531.3;U-937: 593.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA001625 Enhanced Supported Cytosol NA NA 58000000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 32: U-937 - Innate immune response" "Cluster 47: Cytotrophoblasts - Unknown function" Cytosol "HPA001625: AB_1854577" "unprognostic (1.20e-3)" "unprognostic (2.68e-2)" "unprognostic (1.04e-2)" "unprognostic (1.70e-1)" "unprognostic (3.10e-1)" "unprognostic (7.06e-2)" "prognostic unfavorable (4.43e-4)" "unprognostic (4.94e-3)" "unprognostic (3.87e-2)" "unprognostic (7.45e-2)" "unprognostic (1.85e-2)" "unprognostic (2.21e-1)" "prognostic favorable (2.24e-4)" "unprognostic (1.69e-1)" "unprognostic (7.54e-2)" "unprognostic (2.46e-1)" "unprognostic (1.64e-3)" 78.6 24.8 16.1 46.8 16.6 333.9 34.6 22.6 22.7 25.3 18.9 52.2 120.3 14.2 594.8 87.4 18.2 56.8 29.0 17.7 19.6 206.8 98.0 48.6 46.7 20.3 18.1 5.0 23.2 32.0 19.8 132.6 20.1 15.0 61.8 27.1 22.6 27.4 7.3 29.6 60.3 38.7 23.1 44.5 50.6 7.4 21.1 33.5 17.8 10.0 64.4 100.4 41.5 20.1 86.1 113.4 24.0 53.9 26.0 21.0 71.8 85.2 40.3 68.2 67.0 66.1 76.5 227.1 96.8 45.5 81.5 89.9 125.2 159.8 89.5 75.0 109.6 189.1 89.9 109.3 24.2 531.3 94.7 14.4 57.4 206.0 91.0 37.8 295.9 141.0 95.4 137.4 86.7 79.1 157.6 311.3 67.5 215.7 186.1 130.2 35.9 88.3 243.7 79.6 101.9 22.6 163.4 205.0 13.2 32.6 75.5 92.5 240.0 46.1 62.6 105.1 148.4 63.1 113.3 258.9 39.3 593.0 4.6 12.0 30.6 10.3 39.8 27.3 73.6 25.7 44.2 45.0 48.1 28.8 27.6 35.9 3.7 38.5 26.6 27.3 16.7 31.1 16.1 16.6 22.6 22.7 17.7 19.6 20.3 18.1 20.1 23.1 21.1 20.1 149.6 0.0 23.5 5.9 50.3 84.6 67.4 12.6 112.7 4.7 56.3 62.6 3.5 27.1 13.4 82.8 14.6 360.6 45.2 61.1 39.2 43.2 1.3 36.0 12.7 139.4 46.4 227.3 0.6 51.5 41.8 32.4 106.5 65.3 57.7 5.0 24.3 30.6 70.9 16.8 1.1 51.3 18.3 18.1 58.4 0.8 0.3 83.3 30.2 3.7 13.2 78.8 29.9 3.0 0.9 130.8 83.9 0.7 88.6 27.5 41.2 118.9 10.5 18.1 0.0 23.9 41.3 0.4 0.7 114.7 63.9 646.2 62.3 3.1 51.4 77.1 PNPLA1 "dJ50J22.1, FLJ38755" ENSG00000180316 "Patatin like phospholipase domain containing 1" Q8N8W4 6 36243203-36313955 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism" Transferase "Disease variant, Ichthyosis" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "skin 1: 23.9" "Cell type enhanced" "Detected in some" "Excitatory neurons: 1.9;granulocytes: 4.5;Oligodendrocyte precursor cells: 1.5;Proximal enterocytes: 1.5;Proximal tubular cells: 3.8;Suprabasal keratinocytes: 3.7" "Cancer enhanced" "Detected in some" "head and neck cancer: 1.0" "Not detected" "Not detected" "Group enriched" "Detected in many" 7 "basophil: 69.8;eosinophil: 18.9" "Lineage enriched" "Detected in many" 17 "granulocytes: 69.8" "Cell line enriched" "Detected in some" 4 "U-937: 17.6" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 61: Skin - Cornification" "Cluster 32: U-937 - Innate immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "unprognostic (3.57e-2)" "unprognostic (2.04e-2)" "unprognostic (1.06e-1)" "unprognostic (3.95e-4)" "unprognostic (1.69e-1)" "unprognostic (1.47e-1)" "unprognostic (7.37e-2)" "unprognostic (2.49e-1)" "unprognostic (8.89e-2)" "unprognostic (1.13e-2)" "unprognostic (2.95e-1)" "unprognostic (2.76e-2)" "unprognostic (2.70e-2)" "unprognostic (9.85e-2)" "unprognostic (2.06e-1)" "unprognostic (2.04e-2)" "unprognostic (1.65e-2)" 0.1 0.2 0.1 0.6 0.2 4.3 0.6 0.3 0.4 0.3 0.0 0.1 0.7 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.1 4.7 0.1 0.2 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.1 0.1 0.0 0.0 0.2 23.9 0.9 0.2 0.1 0.7 1.7 1.0 0.2 0.1 0.1 0.0 0.1 0.2 0.6 0.3 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.7 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.1 0.0 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.1 0.1 0.0 0.0 0.0 0.0 0.0 3.9 0.1 0.0 0.1 0.1 0.1 0.1 0.1 0.0 0.0 17.6 0.0 69.8 4.0 18.9 0.0 2.2 0.0 0.0 0.0 0.0 1.8 0.1 0.0 0.2 6.2 0.1 1.1 0.0 0.0 1.1 0.1 0.2 0.3 0.4 0.1 0.1 0.2 0.0 0.2 0.1 0.2 0.3 0.0 0.0 0.0 1.0 0.0 0.9 0.5 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.1 0.1 0.0 0.0 1.9 0.0 0.0 0.1 0.0 0.2 4.5 0.7 0.0 0.0 0.2 0.0 1.2 0.4 0.0 0.0 0.3 1.3 0.0 0.1 0.0 0.0 0.7 0.0 0.0 1.5 0.7 0.1 0.0 0.0 0.0 0.1 1.5 3.8 0.0 0.0 0.0 0.2 0.0 0.4 0.0 0.0 3.7 0.1 0.0 0.4 0.2 0.2 PNPLA3 "adiponutrin, ADPN, C22orf20, dJ796I17.1, FLJ22012, iPLA2epsilon" ENSG00000100344 "Patatin like phospholipase domain containing 3" Q9NST1 22 43923792-43964488 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Acyltransferase, Hydrolase, Transferase" "Disease variant, Obesity" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "liver: 31.0" "Cell type enhanced" "Detected in some" "Bipolar cells: 35.9;Cone photoreceptor cells: 18.8;Hepatocytes: 42.3;Rod photoreceptor cells: 37.3" "Cancer enhanced" "Detected in many" "liver cancer: 4.9" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 16.7;LHCN-M2: 19.3" "Region enhanced" "Detected in many" "cerebellum: 12.2" "Not detected" "Not detected" HPA058058 Approved Approved Nucleoli,Mitochondria,Cytosol NA NA "Cluster 85: Liver - Metabolism" "Cluster 12: NES - Nervous system development" "Cluster 9: Photoreceptor cells - Phototransduction" Nucleoli "Mitochondria, Cytosol" "HPA058058: AB_2683590" "unprognostic (4.74e-3)" "unprognostic (4.52e-2)" "unprognostic (1.76e-1)" "unprognostic (2.31e-1)" "unprognostic (1.36e-2)" "unprognostic (1.89e-1)" "unprognostic (8.93e-2)" "unprognostic (1.02e-1)" "unprognostic (2.63e-1)" "unprognostic (2.93e-1)" "unprognostic (2.33e-2)" "unprognostic (1.05e-1)" "unprognostic (1.39e-3)" "unprognostic (2.52e-3)" "unprognostic (5.91e-2)" "unprognostic (2.02e-2)" "unprognostic (1.01e-1)" 2.6 0.2 0.6 0.5 0.8 0.1 1.6 0.1 1.2 0.6 5.9 0.1 0.8 0.3 0.1 0.2 0.9 0.4 0.2 1.2 0.7 4.5 31.0 0.8 0.3 1.7 1.8 0.3 0.0 0.2 0.0 0.3 2.0 0.0 0.1 6.4 0.7 0.0 1.7 5.8 0.5 0.0 0.2 0.4 0.2 0.4 1.3 0.1 0.1 0.1 0.2 0.0 0.3 0.6 5.1 1.6 16.7 6.8 4.6 5.2 0.5 3.1 1.8 4.1 8.8 5.0 9.0 0.0 2.5 5.2 2.4 4.3 10.6 5.0 3.4 0.0 0.9 0.3 4.5 9.4 7.5 0.0 0.3 6.0 3.8 13.2 0.6 7.0 0.5 0.2 0.0 0.0 19.3 0.7 0.3 0.0 11.5 0.6 0.0 0.1 8.9 0.2 1.7 0.2 1.5 0.1 3.4 1.4 4.8 2.9 5.3 5.8 0.6 1.6 4.9 0.1 0.1 0.1 0.0 0.0 14.3 0.1 6.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.6 0.8 0.1 1.2 1.2 0.7 1.7 1.8 2.0 0.2 1.3 0.6 0.4 0.0 0.0 4.2 0.2 0.4 0.5 2.4 0.0 35.9 0.5 0.1 1.3 10.0 1.4 0.0 18.8 0.0 0.2 0.2 0.0 0.4 0.0 1.5 0.5 0.4 1.8 0.0 1.9 0.0 0.1 0.5 0.0 3.6 0.0 1.9 0.7 42.3 0.7 0.0 1.2 0.8 0.0 2.8 0.3 0.3 0.3 0.9 1.8 0.0 0.0 1.1 0.0 0.0 0.8 2.6 0.0 0.7 0.0 0.7 0.4 5.0 0.1 37.3 0.0 1.0 0.8 0.6 0.6 0.0 0.1 0.0 0.2 1.6 0.4 0.4 PNPT1 "DFNB70, old-35, OLD35, PNPase" ENSG00000138035 "Polyribonucleotide nucleotidyltransferase 1" Q8TCS8 2 55634061-55693863 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "mRNA processing, Transport" "Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, RNA-binding, Transferase" "Deafness, Disease variant, Non-syndromic deafness, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB033424, HPA034602, HPA034603" Supported Supported Mitochondria,Cytosol NA NA "Cluster 6: Non-specific - Transcription" "Cluster 80: Striated muscle - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 11: Alveolar cells - Smell perception" Mitochondria Cytosol "CAB033424: AB_2299801, HPA034602: AB_2674243, HPA034603: AB_10603130" "unprognostic (9.09e-2)" "unprognostic (7.40e-2)" "unprognostic (2.30e-1)" "prognostic unfavorable (5.57e-4)" "unprognostic (3.40e-2)" "unprognostic (1.03e-2)" "prognostic unfavorable (1.95e-7)" "unprognostic (1.88e-1)" "unprognostic (5.93e-3)" "unprognostic (5.23e-2)" "prognostic unfavorable (5.44e-5)" "unprognostic (2.19e-2)" "unprognostic (2.11e-2)" "unprognostic (6.92e-2)" "unprognostic (1.94e-1)" "unprognostic (2.41e-1)" "unprognostic (1.21e-1)" 6.7 5.9 5.4 4.0 7.0 7.4 5.7 6.4 7.7 5.2 6.4 5.7 3.3 6.4 4.5 4.6 5.7 3.0 6.6 4.8 6.5 5.6 5.2 5.0 4.3 6.9 6.0 4.8 7.8 4.9 5.0 2.9 7.1 4.4 5.2 5.5 5.0 3.2 11.5 5.9 5.3 4.2 5.7 6.2 5.8 3.2 6.3 3.4 5.2 5.9 3.3 5.6 4.5 9.0 9.0 4.3 6.5 2.9 4.7 7.8 8.4 12.2 7.7 19.8 13.1 13.5 4.2 17.9 5.4 5.8 6.2 7.1 8.3 10.1 9.5 6.3 16.3 10.2 5.9 7.0 11.8 25.0 6.4 8.6 6.9 8.4 7.0 4.7 6.4 7.3 11.5 4.2 8.0 4.4 15.4 17.9 15.5 9.3 8.1 15.2 10.9 16.6 8.6 5.2 15.2 9.6 4.4 14.3 17.0 5.6 3.8 11.4 6.4 4.6 3.9 4.2 13.5 18.9 1.3 3.8 9.2 21.1 8.3 3.3 3.4 4.0 4.2 2.8 2.4 3.1 1.7 4.1 1.3 5.6 3.4 3.9 3.4 2.2 2.7 4.1 1.4 2.9 5.4 7.0 6.4 7.7 4.8 6.5 6.9 6.0 7.1 5.7 6.3 9.0 25.1 48.1 57.0 23.8 21.6 24.2 23.1 17.5 29.0 41.3 12.6 11.2 25.6 15.7 46.8 20.2 58.4 19.9 14.2 7.7 9.8 18.6 25.6 27.9 28.9 24.4 10.2 17.4 48.4 16.0 23.3 25.3 14.8 14.3 58.7 21.8 11.7 14.7 15.4 30.3 48.1 12.8 26.4 12.2 17.7 4.8 17.4 26.7 16.0 17.8 16.5 23.9 13.4 34.2 97.7 15.8 11.4 18.4 23.1 26.0 7.6 19.8 38.5 58.6 26.3 31.7 22.3 43.4 20.7 25.7 20.2 12.3 24.7 58.2 18.6 17.6 POFUT1 "FUT12, KIAA0180, O-Fuc-T, O-FUT" ENSG00000101346 "Protein O-fucosyltransferase 1" Q9H488 20 32207880-32238658 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Carbohydrate metabolism, Fucose metabolism, Notch signaling pathway" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Hepatocytes: 39.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "non-classical monocyte: 20.9" "Lineage enriched" "Detected in all" 5 "monocytes: 20.9" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA054519, HPA059935" Approved Approved Centrosome "Intracellular and membrane" NA NA 60000 "Cluster 51: Monocytes - Innate immune response" "Cluster 1: Thyroid gland - Transcription" "Cluster 32: U-937 - Innate immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" Centrosome "HPA054519: AB_2682515, HPA059935: AB_2684171" "unprognostic (6.61e-2)" "unprognostic (4.10e-3)" "unprognostic (8.83e-2)" "unprognostic (5.51e-3)" "unprognostic (6.90e-2)" "unprognostic (1.62e-1)" "unprognostic (4.65e-1)" "unprognostic (8.51e-2)" "unprognostic (1.84e-1)" "unprognostic (5.57e-2)" "unprognostic (3.01e-1)" "unprognostic (2.19e-1)" "unprognostic (6.76e-2)" "unprognostic (6.15e-2)" "unprognostic (3.13e-1)" "unprognostic (1.03e-2)" "unprognostic (5.86e-3)" 17.6 10.8 7.9 11.7 8.4 10.5 16.5 7.2 7.7 15.2 9.1 20.0 20.4 14.9 14.4 12.4 20.4 11.4 17.5 7.7 7.3 16.1 30.9 12.2 9.1 9.3 8.3 20.0 13.8 23.8 9.1 16.4 8.0 14.5 19.1 5.9 13.0 18.1 12.8 13.7 24.0 18.1 8.0 9.4 11.1 9.5 8.1 10.5 18.9 14.0 10.0 14.0 10.9 8.2 47.1 37.2 31.5 34.7 52.9 51.4 58.8 47.8 56.2 78.8 51.3 111.9 62.1 31.7 69.8 53.5 87.2 51.2 30.5 59.0 68.0 16.5 19.2 47.1 32.1 51.2 41.2 41.0 28.9 45.4 45.7 59.7 38.8 33.5 44.6 30.0 36.3 17.6 55.6 23.1 28.4 31.4 16.2 45.2 59.4 23.3 83.6 29.5 24.2 30.7 20.6 26.5 109.5 30.0 41.0 24.0 44.7 48.5 38.8 113.4 42.2 71.8 82.4 21.4 29.3 28.7 68.5 139.9 73.0 4.3 5.4 2.6 3.2 15.1 3.6 3.2 2.8 3.0 4.6 2.6 3.6 2.5 1.0 2.0 20.9 3.4 3.3 4.2 7.9 8.4 7.2 7.7 7.7 7.3 9.3 8.3 8.0 8.0 8.1 8.2 7.8 9.6 9.5 11.1 5.2 2.9 4.7 8.6 5.2 3.1 7.2 7.1 13.4 8.6 7.9 7.3 2.1 15.2 5.7 17.5 1.9 10.0 0.9 7.1 10.8 9.3 12.0 9.2 9.0 10.4 28.2 12.0 9.2 13.6 5.1 13.1 13.9 39.8 10.7 8.4 9.0 13.4 2.0 8.1 3.8 1.7 10.5 6.5 5.4 6.5 9.3 5.2 3.1 11.1 9.6 9.6 11.9 14.3 8.2 6.7 31.7 5.3 7.2 4.3 13.1 11.1 9.4 2.9 7.3 9.7 1.7 7.7 5.0 26.0 19.0 4.1 POFUT2 "C21orf80, FUT13, KIAA0958" ENSG00000186866 "Protein O-fucosyltransferase 2" Q9Y2G5 21 45263928-45287898 "Enzymes, Predicted intracellular proteins" "Carbohydrate metabolism, Fucose metabolism" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Late spermatids: 51.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in all" "fHDF/TERT166: 95.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044297 Uncertain "Intracellular and membrane" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 72: Non-specific - Transcription" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 33: Fibroblasts - ECM organization" "HPA044297: AB_10965176" "unprognostic (1.32e-2)" "unprognostic (1.65e-3)" "prognostic unfavorable (4.55e-7)" "unprognostic (1.49e-2)" "unprognostic (4.09e-3)" "unprognostic (5.03e-2)" "prognostic unfavorable (2.78e-4)" "unprognostic (2.62e-1)" "unprognostic (2.15e-1)" "unprognostic (4.16e-2)" "unprognostic (4.20e-3)" "unprognostic (1.48e-2)" "prognostic unfavorable (8.66e-12)" "unprognostic (1.56e-2)" "unprognostic (2.53e-1)" "unprognostic (3.91e-3)" "unprognostic (5.25e-2)" 15.7 20.7 9.4 8.5 9.6 14.0 14.1 9.5 10.9 20.2 21.2 17.3 9.7 16.1 8.9 8.6 20.4 10.3 16.6 9.6 13.8 19.6 20.5 16.1 7.7 11.9 12.1 27.7 19.0 8.2 31.4 16.8 11.8 19.1 6.3 8.6 14.5 10.3 7.8 8.6 15.0 12.0 9.6 16.9 15.3 17.6 13.7 5.3 22.2 5.1 6.5 15.9 13.9 9.6 10.4 11.2 22.1 24.5 39.3 36.1 10.3 57.1 45.4 25.9 38.7 24.0 17.2 7.2 41.9 95.1 58.5 10.4 13.1 22.9 27.9 12.1 15.2 14.4 17.4 18.8 45.4 10.7 18.4 25.6 14.7 32.4 17.7 84.5 25.6 9.5 13.5 11.6 27.4 10.7 5.3 17.7 27.6 17.3 15.7 10.8 6.6 9.1 14.4 9.4 9.6 14.0 33.6 20.3 21.1 24.6 14.8 15.4 28.5 19.5 19.0 30.2 25.8 27.7 15.4 5.5 39.9 13.2 30.8 0.3 0.3 0.8 0.3 0.3 0.5 0.2 0.3 0.2 0.1 0.2 0.4 0.4 0.5 0.3 0.3 0.4 0.3 0.3 9.4 9.6 9.5 10.9 9.6 13.8 11.9 12.1 11.8 9.6 13.7 9.6 12.4 6.4 9.6 19.6 10.7 6.6 7.0 6.8 6.2 6.9 11.8 9.5 8.7 11.5 7.0 12.9 10.4 9.0 14.7 7.4 3.9 7.6 34.9 29.4 17.5 8.7 10.1 7.4 6.8 6.2 13.5 19.8 13.3 15.9 7.0 20.4 10.0 8.6 6.9 5.0 9.9 14.7 4.1 4.8 8.8 51.2 14.6 8.1 8.8 7.5 8.0 10.2 3.1 11.1 7.6 8.0 7.5 13.9 12.4 7.3 6.6 3.9 30.6 14.5 0.0 14.5 17.5 20.1 5.2 4.5 4.0 13.5 12.3 12.2 7.8 7.9 POGLUT1 "9630046K23Rik, C3orf9, hCLP46, KDELCL1, KTELC1, MDS010, MDSRP, MGC32995, Rumi" ENSG00000163389 "Protein O-glucosyltransferase 1" Q8NBL1 3 119468963-119494708 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Gastrulation "Developmental protein, Glycosyltransferase, Transferase" "Disease variant, Limb-girdle muscular dystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Langerhans cells: 81.2;monocytes: 151.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037855, HPA037856" Approved Supported "Endoplasmic reticulum" "Intracellular and membrane" NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 25: RPMI-8226 - Immune response" "Cluster 3: Monocytes - Immune response regulation" "Endoplasmic reticulum" "HPA037855: AB_10672728, HPA037856: AB_2732477" "unprognostic (2.43e-1)" "unprognostic (5.94e-2)" "unprognostic (1.19e-1)" "unprognostic (1.83e-2)" "unprognostic (5.62e-2)" "unprognostic (2.00e-2)" "unprognostic (3.38e-1)" "unprognostic (2.81e-2)" "unprognostic (1.84e-2)" "unprognostic (1.03e-1)" "unprognostic (6.52e-3)" "unprognostic (1.31e-2)" "prognostic unfavorable (7.02e-7)" "unprognostic (3.08e-2)" "unprognostic (1.89e-1)" "unprognostic (1.23e-3)" "prognostic favorable (2.23e-4)" 6.8 7.2 5.9 7.8 6.1 3.1 7.7 6.0 8.2 7.1 6.9 6.8 4.2 9.0 7.8 5.6 6.0 4.7 5.9 5.9 7.2 5.7 6.6 5.6 10.8 6.6 6.5 5.5 7.9 9.5 4.9 8.2 6.6 5.4 7.2 4.2 4.6 11.6 3.2 10.0 7.8 10.4 6.1 9.0 5.4 2.5 7.2 9.7 5.6 3.4 10.8 8.5 6.3 6.7 10.8 7.1 11.7 13.1 29.5 16.8 8.6 16.7 16.7 12.3 18.4 11.5 6.9 16.5 22.2 21.4 10.6 11.9 15.9 16.8 20.4 14.4 10.6 19.3 11.1 12.9 19.1 21.3 21.7 17.5 9.6 13.3 18.0 15.7 15.5 11.2 10.5 19.7 13.9 10.9 12.5 20.7 12.4 18.6 13.8 12.2 12.2 24.0 11.6 13.9 12.7 20.0 8.1 4.9 13.4 11.7 13.2 17.8 19.7 13.1 8.0 3.8 8.9 27.1 25.2 21.7 11.1 20.6 18.8 2.9 16.4 13.9 16.2 15.7 18.7 13.9 18.2 17.0 20.7 10.1 21.1 20.0 1.2 29.5 10.8 11.5 22.3 15.0 5.9 6.1 6.0 8.2 5.9 7.2 6.6 6.5 6.6 6.1 7.2 6.7 19.1 0.0 6.2 11.4 15.7 16.8 7.3 17.4 16.5 13.6 9.7 8.5 5.2 14.3 10.1 20.2 6.2 10.6 17.1 5.2 0.0 6.9 0.7 5.5 19.3 16.1 9.5 8.4 32.7 5.3 14.7 14.5 9.2 7.0 17.7 11.3 13.6 12.5 8.4 5.0 31.6 11.7 22.4 11.9 81.2 0.2 8.7 16.6 12.4 6.5 151.4 10.3 21.6 23.6 25.8 5.0 8.3 17.0 14.1 8.0 8.5 6.0 6.5 13.0 13.1 16.7 13.4 1.5 1.5 13.9 14.9 6.6 15.5 17.4 13.9 5.9 POLA1 "NSX, p180, POLA" ENSG00000101868 "DNA polymerase alpha 1, catalytic subunit" P09884 X 24693873-24996986 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "DNA replication, Host-virus interaction" "DNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase" "Disease variant, Dwarfism, FDA approved drug targets, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 38.5;Excitatory neurons: 42.3;Inhibitory neurons: 65.7;Microglial cells: 57.1;Oligodendrocyte precursor cells: 59.3;Oligodendrocytes: 97.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002947, CAB012274" Supported Supported Nucleoplasm,Cytosol NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm Cytosol "CAB012274: , HPA002947: AB_1079652" "unprognostic (6.92e-2)" "unprognostic (4.43e-3)" "unprognostic (3.27e-3)" "unprognostic (1.53e-2)" "unprognostic (2.53e-1)" "unprognostic (1.49e-1)" "prognostic unfavorable (4.80e-5)" "unprognostic (1.87e-1)" "unprognostic (9.25e-3)" "unprognostic (2.48e-2)" "unprognostic (8.41e-2)" "unprognostic (7.42e-2)" "unprognostic (2.09e-1)" "unprognostic (1.44e-1)" "unprognostic (3.66e-2)" "unprognostic (3.48e-2)" "unprognostic (3.08e-1)" 3.7 2.0 1.9 4.8 2.5 7.3 5.1 2.2 1.8 4.3 0.8 4.1 2.4 4.2 1.4 3.9 3.7 2.1 3.5 1.3 1.9 2.9 2.0 3.1 6.8 2.3 2.3 5.8 2.8 3.4 1.8 5.6 2.4 3.1 5.2 3.7 3.0 3.5 4.9 4.0 3.5 4.8 2.2 3.5 3.7 2.6 2.1 11.9 3.1 3.1 7.7 3.7 3.8 2.6 32.7 24.6 30.3 24.1 5.2 6.5 6.9 23.6 12.7 25.0 28.3 20.4 17.0 41.1 7.7 9.6 23.4 26.0 59.7 18.7 33.6 21.1 24.8 31.0 42.8 13.5 2.4 41.6 15.5 4.1 3.6 31.2 8.4 5.8 13.0 20.8 28.7 20.0 16.8 22.4 45.2 7.2 30.7 20.3 19.1 39.0 81.5 30.7 7.1 21.1 27.9 16.7 28.1 11.2 11.6 33.0 25.7 11.5 10.1 21.3 14.9 42.4 22.6 11.6 18.1 32.7 12.4 18.3 24.9 0.0 0.2 0.2 0.6 1.4 0.8 1.0 0.8 1.0 0.7 0.4 0.4 0.5 0.0 0.8 0.2 0.2 0.9 0.5 1.9 2.5 2.2 1.8 1.3 1.9 2.3 2.3 2.4 2.2 2.1 2.6 5.8 9.6 6.5 38.5 5.2 2.8 4.6 1.8 5.7 3.9 4.7 4.3 11.8 0.0 7.2 1.8 2.1 6.1 3.2 2.5 3.9 3.2 0.2 3.2 4.7 6.3 4.2 24.2 42.3 3.0 4.9 4.6 4.6 3.8 9.5 8.3 3.3 3.4 4.4 1.7 65.7 4.2 4.1 4.4 1.5 1.7 6.2 4.5 0.0 57.1 3.7 4.8 5.2 59.3 97.7 1.4 1.2 3.4 8.6 2.0 2.3 1.6 6.1 7.4 6.6 9.2 6.0 6.4 4.5 5.5 2.3 2.3 4.9 5.0 4.2 2.4 POLB ENSG00000070501 "DNA polymerase beta" P06746 8 42338454-42371808 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, DNA replication, DNA synthesis" "DNA-binding, DNA-directed DNA polymerase, Lyase, Nucleotidyltransferase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 254.5;Late spermatids: 133.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HMC-1: 280.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011616, HPA049104, HPA069013" Enhanced Uncertain Vesicles NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 21: Non-specific - Transcription" "Cluster 3: HMC-1 - Innate immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Vesicles "CAB011616: AB_731977, HPA049104: AB_2680632, HPA069013: " "unprognostic (1.67e-1)" "unprognostic (2.68e-3)" "unprognostic (2.43e-1)" "prognostic unfavorable (1.46e-4)" "unprognostic (8.49e-2)" "unprognostic (2.64e-2)" "unprognostic (4.24e-2)" "unprognostic (1.02e-1)" "unprognostic (2.31e-2)" "unprognostic (1.99e-1)" "unprognostic (4.57e-2)" "unprognostic (4.77e-1)" "prognostic unfavorable (2.15e-5)" "unprognostic (1.06e-2)" "unprognostic (1.40e-1)" "unprognostic (4.22e-2)" "prognostic favorable (5.65e-4)" 12.4 17.5 26.6 13.5 27.4 51.3 27.4 82.3 35.5 18.9 24.3 12.3 10.8 12.9 19.7 26.5 13.2 17.4 26.1 28.1 29.0 18.0 33.9 14.2 20.2 27.1 27.8 20.4 16.9 18.8 26.7 11.1 28.9 24.8 13.2 18.0 30.3 11.3 85.3 23.1 10.8 10.6 27.6 17.2 14.0 53.1 30.2 24.8 14.2 70.0 22.2 30.8 18.9 28.9 40.2 23.5 40.6 80.4 21.8 20.7 33.8 25.2 29.3 41.5 37.7 33.1 46.0 36.4 31.1 16.5 43.4 20.0 34.1 29.5 50.3 23.8 36.7 26.5 18.2 45.3 34.1 18.6 280.6 18.8 34.4 30.1 35.4 51.8 32.1 77.2 58.4 22.4 40.3 23.6 78.0 52.6 54.4 48.4 26.7 44.2 40.8 31.4 78.4 32.1 22.7 41.8 29.9 19.9 79.0 41.4 52.5 31.5 17.8 19.1 27.0 48.8 24.6 32.5 58.4 52.2 19.3 39.4 52.2 47.6 15.1 48.1 12.0 18.8 13.3 12.2 12.5 13.0 15.7 11.1 14.1 13.3 63.6 22.2 26.3 84.9 19.3 11.5 26.6 27.4 82.3 35.5 28.1 29.0 27.1 27.8 28.9 27.6 30.2 28.9 13.9 3.2 13.6 6.8 20.2 16.8 30.1 14.2 31.3 2.9 14.3 15.1 21.6 7.2 20.7 7.3 8.4 7.5 51.9 3.1 5.9 11.7 254.5 13.8 7.7 12.5 6.0 7.6 15.8 9.6 7.0 9.7 10.2 9.9 23.4 12.7 8.6 12.7 7.4 6.7 20.3 5.4 4.1 5.7 9.9 133.9 7.2 18.2 7.2 19.7 11.2 8.3 13.4 12.5 16.7 33.6 5.8 3.8 21.9 41.6 4.3 6.8 16.4 4.4 0.0 6.6 12.3 19.4 15.4 27.3 20.0 11.1 16.2 7.8 6.6 31.6 POLD1 "CDC2, POLD" ENSG00000062822 "DNA polymerase delta 1, catalytic subunit" P28340 19 50384204-50418018 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA excision, DNA repair, DNA replication" "DNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Paneth cells: 51.3;Spermatogonia: 25.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004375, HPA046524" Supported Supported Nucleoplasm NA NA "Cluster 37: B-cells - Transcription" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "CAB004375: AB_675487, HPA046524: AB_2679684" "unprognostic (2.45e-1)" "unprognostic (7.02e-3)" "unprognostic (1.59e-1)" "unprognostic (4.35e-2)" "unprognostic (2.55e-1)" "unprognostic (1.85e-2)" "prognostic unfavorable (2.87e-6)" "unprognostic (4.12e-2)" "unprognostic (1.16e-2)" "unprognostic (2.83e-1)" "unprognostic (5.08e-1)" "unprognostic (3.92e-3)" "unprognostic (4.01e-3)" "unprognostic (1.28e-2)" "unprognostic (1.61e-1)" "unprognostic (2.89e-1)" "unprognostic (3.70e-2)" 5.6 5.1 3.2 9.2 3.7 26.3 6.3 4.5 3.8 7.6 2.5 8.9 5.4 8.4 0.4 10.7 6.5 2.1 5.8 2.7 2.7 6.5 6.4 9.5 11.2 5.1 3.7 7.1 7.9 2.3 4.7 5.9 4.1 6.1 2.2 1.9 7.4 2.6 5.6 9.2 10.1 2.3 3.5 12.8 6.2 13.3 4.1 11.0 9.8 1.5 5.2 5.9 7.7 4.4 52.1 77.9 27.9 22.4 3.0 2.8 45.6 34.0 9.6 30.0 34.9 42.4 39.2 84.6 19.4 7.1 13.9 45.1 27.4 25.1 6.8 64.4 145.0 66.1 73.0 54.6 3.7 67.0 57.7 6.4 7.1 26.1 6.5 6.0 14.2 58.2 77.4 54.3 9.1 40.6 92.2 110.6 48.7 25.3 55.4 105.4 62.2 67.7 7.4 44.9 39.3 38.6 33.0 35.9 8.8 10.1 21.1 50.7 17.4 21.4 70.7 22.0 56.5 60.0 91.3 76.3 21.2 66.9 20.8 1.3 4.3 1.5 4.3 5.6 4.0 6.0 4.0 3.5 3.9 5.4 4.0 3.9 0.6 4.2 6.9 7.1 3.1 4.0 3.2 3.7 4.5 3.8 2.7 2.7 5.1 3.7 4.1 3.5 4.1 4.4 3.5 3.2 3.9 0.7 8.7 6.4 2.3 3.5 3.4 4.0 4.3 5.3 3.4 2.8 3.8 3.7 6.2 19.2 3.8 12.2 0.0 4.8 1.9 2.8 1.6 3.4 7.2 15.2 1.2 4.0 15.0 4.1 3.1 3.0 0.0 9.5 1.1 2.2 15.1 0.0 0.9 7.4 0.0 5.7 5.3 1.9 3.1 5.8 5.4 1.0 4.8 1.2 6.2 1.5 2.2 4.7 51.3 5.3 10.6 2.8 6.3 2.8 3.0 4.3 0.0 3.5 4.0 11.5 25.6 5.5 5.3 7.7 5.4 3.4 14.3 1.3 POLE POLE1 ENSG00000177084 "DNA polymerase epsilon, catalytic subunit" Q07864 12 132623753-132687376 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, DNA replication" "DNA-binding, DNA-directed DNA polymerase, Hydrolase, Nucleotidyltransferase, Transferase" "Cancer-related genes, Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Spermatocytes: 46.6" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in some" 4 "cerebellum: 4.1;cerebral cortex: 1.1;hippocampal formation: 1.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in single" "Not detected" "Not detected" "HPA058210, HPA067385" Supported "Nucleoplasm,Plasma membrane" NA NA "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 24: NB-4 - Immune response" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "Plasma membrane" "HPA058210: AB_2683639, HPA067385: AB_2685830" "unprognostic (1.60e-1)" "unprognostic (1.77e-3)" "unprognostic (2.00e-1)" "unprognostic (9.17e-2)" "unprognostic (1.68e-1)" "unprognostic (2.01e-2)" "unprognostic (3.96e-3)" "unprognostic (2.23e-1)" "prognostic unfavorable (1.44e-4)" "unprognostic (7.12e-2)" "unprognostic (2.21e-1)" "unprognostic (1.67e-1)" "prognostic unfavorable (3.19e-8)" "unprognostic (8.60e-2)" "unprognostic (3.18e-1)" "unprognostic (1.28e-1)" "unprognostic (9.95e-2)" 6.0 2.9 0.2 6.1 0.2 24.7 6.0 4.1 1.1 6.4 0.3 7.3 6.5 5.4 2.1 7.0 6.2 3.1 4.3 1.6 0.0 3.0 8.6 5.0 7.2 0.3 0.1 7.8 6.5 2.6 2.7 5.3 0.3 6.4 6.3 2.4 6.1 3.3 7.5 13.2 8.5 3.7 0.1 16.2 8.0 16.2 0.5 15.7 4.7 3.0 7.1 6.1 6.2 0.3 25.3 33.3 48.7 22.0 10.2 7.6 39.9 26.0 11.7 30.3 21.8 38.3 14.5 28.7 10.2 14.1 11.6 33.6 35.4 16.7 18.8 13.3 41.2 45.4 45.7 15.2 1.9 37.2 24.9 5.5 6.0 31.8 10.5 8.1 10.8 35.1 53.4 15.7 14.9 33.3 61.8 46.8 36.9 9.3 18.5 48.0 27.6 13.0 6.9 40.8 40.6 22.0 30.0 22.7 4.7 23.4 35.0 19.1 9.9 26.5 24.7 20.6 25.9 20.3 14.5 44.8 14.7 26.3 19.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.1 0.0 0.2 0.2 4.1 1.1 1.6 0.0 0.3 0.1 0.3 0.1 0.5 0.3 3.2 0.0 6.7 7.5 4.0 5.7 3.8 3.0 4.0 8.7 7.8 6.7 6.9 1.5 1.6 1.8 0.0 8.8 5.6 18.8 0.0 2.3 8.2 3.2 3.8 4.9 7.2 14.9 13.6 3.3 10.8 5.1 11.2 6.8 2.5 16.2 8.9 10.5 13.2 0.0 7.6 9.1 2.0 6.9 5.4 9.7 6.8 2.9 5.4 4.7 1.6 2.6 2.1 3.5 2.9 2.6 6.0 3.4 6.3 4.0 4.1 1.0 1.9 6.1 26.3 7.0 6.1 46.6 18.2 5.8 7.7 4.0 5.8 2.9 10.9 2.8 POLG "POLG1, POLGA" ENSG00000140521 "DNA polymerase gamma, catalytic subunit" P54098 15 89305198-89334861 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA replication" "DNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase" "Disease variant, Epilepsy, Leigh syndrome, Neurodegeneration, Neuropathy, Primary mitochondrial disease, Progressive external ophthalmoplegia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA056821, HPA078482" Approved Supported Mitochondria NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 72: Non-specific - Transcription" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 65: Plasmacytoid DCs - Unknown function" Mitochondria "HPA056821: AB_2683247, HPA078482: " "unprognostic (1.87e-1)" "unprognostic (4.71e-2)" "unprognostic (2.61e-2)" "unprognostic (3.64e-1)" "unprognostic (1.62e-1)" "unprognostic (3.19e-1)" "unprognostic (2.22e-1)" "unprognostic (1.13e-1)" "unprognostic (8.41e-2)" "unprognostic (2.63e-1)" "unprognostic (1.41e-1)" "prognostic unfavorable (5.73e-4)" "unprognostic (2.65e-3)" "unprognostic (1.58e-2)" "unprognostic (4.29e-2)" "unprognostic (2.07e-1)" "unprognostic (3.45e-1)" 13.3 11.1 6.8 4.0 5.0 2.6 12.0 4.8 6.3 12.0 4.5 13.3 5.5 12.9 0.4 14.6 11.2 0.9 13.8 6.1 3.5 10.1 12.9 13.8 3.0 9.0 5.8 10.8 10.7 2.9 8.4 2.5 6.5 10.5 0.9 1.4 12.3 2.2 25.0 16.0 14.5 1.3 5.4 16.2 11.9 5.4 5.7 7.3 10.5 10.9 2.4 12.2 12.7 6.3 8.0 17.0 6.7 10.0 7.7 1.6 16.4 16.4 2.7 7.9 5.9 28.0 10.9 14.4 33.6 5.9 16.9 11.8 14.3 4.8 0.9 35.8 31.3 19.4 19.5 11.1 10.8 21.3 33.6 2.4 8.7 7.0 3.0 8.3 12.2 26.8 19.5 5.4 6.1 22.8 16.3 16.5 8.7 13.7 8.2 18.2 13.7 17.4 3.2 19.2 24.5 6.9 26.8 9.6 16.8 6.0 7.7 10.8 17.3 12.8 15.6 28.5 14.2 17.0 9.4 18.6 9.5 14.3 11.6 3.3 4.3 6.1 5.5 4.0 4.3 2.0 4.6 6.8 6.0 3.0 3.7 4.4 1.8 5.0 3.5 4.1 3.3 5.3 6.8 5.0 4.8 6.3 6.1 3.5 9.0 5.8 6.5 5.4 5.7 6.3 15.7 12.8 11.9 11.4 17.2 12.2 11.0 10.7 9.1 7.6 12.0 10.3 19.0 11.5 9.5 11.0 2.1 15.0 33.8 17.2 9.8 10.4 1.3 8.4 9.4 12.4 5.4 9.0 12.9 10.9 15.8 11.9 21.4 11.3 8.2 14.8 14.6 17.8 12.7 3.3 9.9 24.9 4.1 18.5 14.7 1.5 14.3 17.2 19.6 8.4 21.8 6.1 30.9 9.5 11.9 11.4 15.9 10.5 16.8 17.7 10.5 7.5 7.8 6.4 6.6 13.3 12.9 9.2 11.1 11.8 11.9 21.8 21.7 14.8 17.6 15.5 POLH "RAD30A, XP-V" ENSG00000170734 "DNA polymerase eta" Q9Y253 6 43576185-43620523 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, DNA replication, DNA synthesis" "DNA-binding, DNA-directed DNA polymerase, Mutator protein, Nucleotidyltransferase, Transferase" "Disease variant, Xeroderma pigmentosum" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Spermatocytes: 25.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-698: 91.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006721, HPA026762" Approved Enhanced Nucleoplasm NA Yes "Cluster 15: NK-cells - Transcription" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 57: B-cells - Immune response" Nucleoplasm "HPA006721: AB_1847785, HPA026762: AB_10601248" "unprognostic (1.79e-1)" "unprognostic (7.29e-2)" "unprognostic (2.25e-1)" "unprognostic (7.28e-2)" "unprognostic (3.61e-1)" "unprognostic (5.11e-3)" "unprognostic (9.68e-2)" "unprognostic (1.40e-1)" "unprognostic (3.18e-1)" "unprognostic (7.75e-2)" "unprognostic (4.11e-3)" "unprognostic (2.24e-1)" "unprognostic (9.50e-2)" "unprognostic (6.73e-2)" "unprognostic (8.77e-2)" "unprognostic (7.91e-2)" "unprognostic (6.02e-2)" 5.0 3.8 2.3 6.9 2.7 4.2 4.8 5.1 2.9 5.9 5.3 7.0 4.6 4.2 3.6 5.5 5.5 4.3 3.7 2.2 2.2 4.7 5.6 5.7 12.9 2.7 2.2 4.7 5.4 3.7 3.2 4.0 2.7 4.7 7.2 7.4 4.0 3.8 8.5 8.5 4.4 6.3 1.8 5.6 4.6 10.6 2.5 12.9 6.8 4.7 14.2 4.8 4.3 3.6 46.7 9.7 13.5 19.9 17.6 29.1 33.0 48.6 13.9 26.2 29.2 12.0 7.9 48.9 12.0 17.6 7.6 11.4 13.1 28.6 31.5 25.9 10.0 15.3 31.6 35.5 13.4 26.8 19.2 19.5 33.4 21.5 11.3 10.6 24.3 14.5 24.0 29.6 33.0 15.0 23.9 6.4 4.2 33.2 7.2 25.1 14.3 11.8 9.9 34.6 15.1 5.4 14.5 12.9 7.3 15.4 17.9 10.8 36.2 23.6 24.4 12.2 25.2 28.0 21.3 91.1 11.8 14.5 27.3 4.1 1.7 2.7 4.2 1.6 3.8 5.0 3.5 3.1 1.3 4.9 2.8 3.0 1.7 4.2 1.6 2.6 4.6 2.0 2.3 2.7 5.1 2.9 2.2 2.2 2.7 2.2 2.7 1.8 2.5 3.6 3.1 12.8 8.2 12.1 15.1 4.7 3.2 4.8 19.4 6.3 3.4 3.3 2.3 5.7 6.5 3.7 10.4 2.4 5.2 6.3 5.9 2.1 11.4 10.2 4.8 2.8 5.4 5.7 14.8 0.9 2.8 5.3 8.2 9.0 0.0 6.1 1.4 2.4 1.7 0.0 15.3 2.2 4.1 2.2 2.2 7.3 3.4 3.0 1.8 6.5 3.2 2.6 2.1 10.1 13.4 1.9 4.5 3.0 12.7 2.2 3.1 2.3 5.4 9.4 0.0 7.0 5.0 25.9 6.7 13.0 3.0 1.9 8.8 5.6 3.0 2.3 POLI "RAD30B, RAD3OB" ENSG00000101751 "DNA polymerase iota" Q9UNA4 18 54269517-54321266 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, DNA replication, DNA synthesis" "DNA-binding, DNA-directed DNA polymerase, Mutator protein, Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 117.4;Spermatocytes: 80.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA012000, HPA064696" Enhanced Supported "Nuclear speckles,Cytoplasmic bodies" NA NA "Cluster 24: B-cells - Unknown function" "Cluster 1: Thyroid gland - Transcription" "Cluster 12: NES - Nervous system development" "Cluster 66: Spermatocytes - Spermatogenesis" "Nuclear speckles" "Cytoplasmic bodies" "HPA012000: AB_1847786, HPA064696: AB_2685325" "unprognostic (1.64e-1)" "unprognostic (5.79e-3)" "unprognostic (9.72e-3)" "unprognostic (4.92e-2)" "unprognostic (3.04e-1)" "unprognostic (4.46e-2)" "unprognostic (1.31e-1)" "unprognostic (1.05e-2)" "unprognostic (4.04e-3)" "unprognostic (2.22e-2)" "unprognostic (2.07e-3)" "unprognostic (1.30e-3)" "unprognostic (1.55e-1)" "unprognostic (4.05e-2)" "unprognostic (1.26e-1)" "unprognostic (1.52e-2)" "unprognostic (6.99e-2)" 21.2 9.2 7.6 7.2 10.6 7.0 18.2 7.4 9.2 13.8 4.8 9.5 7.8 15.0 14.4 7.2 11.3 9.6 10.7 5.7 8.5 14.4 7.5 10.0 9.6 9.5 8.0 16.7 13.4 15.8 11.5 14.8 8.3 14.1 8.6 25.4 8.2 14.6 6.3 7.5 6.6 11.5 8.6 9.4 9.7 38.0 8.5 14.6 31.4 5.6 8.4 9.4 8.7 12.9 12.0 4.3 31.4 19.1 10.3 20.1 10.2 9.7 20.6 10.9 18.0 3.2 11.1 5.6 3.1 14.2 11.1 9.6 7.4 11.1 12.2 13.7 3.7 7.1 5.2 8.3 16.9 11.4 5.5 21.9 16.4 9.5 19.6 24.5 23.4 9.1 4.9 15.6 18.3 9.6 8.2 9.9 10.8 3.0 4.7 5.1 6.4 14.1 12.3 15.9 14.6 14.9 6.9 6.0 10.1 20.2 22.1 5.1 11.3 20.4 5.5 3.1 8.2 12.6 3.0 7.9 14.5 10.0 15.1 4.0 6.3 6.7 4.6 3.5 4.3 5.1 4.8 4.8 6.1 6.5 7.0 4.0 3.9 4.9 3.7 4.8 6.1 3.9 7.6 10.6 7.4 9.2 5.7 8.5 9.5 8.0 8.3 8.6 8.5 12.9 8.7 25.6 16.4 24.5 5.0 2.5 8.0 9.1 10.8 15.3 12.1 10.0 10.5 2.8 9.6 5.5 10.4 33.5 4.7 1.8 9.8 9.0 117.4 14.4 12.3 8.0 6.1 5.0 16.5 6.2 16.6 11.0 9.2 10.3 13.3 13.9 8.9 6.1 9.2 3.3 20.3 4.7 8.2 5.9 2.5 25.4 19.9 6.2 7.2 26.2 8.2 18.7 7.2 28.6 43.5 6.2 2.6 18.0 3.3 4.7 3.7 15.6 20.6 23.6 32.9 13.9 9.6 80.1 31.4 4.9 2.6 27.9 6.4 11.7 4.3 3.1 POLK "DINB1, DINP, POLQ" ENSG00000122008 "DNA polymerase kappa" Q9UBT6 5 75511756-75601144 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, DNA replication, DNA synthesis" "DNA-binding, DNA-directed DNA polymerase, Mutator protein, Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 236.8;Oligodendrocytes: 159.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA012035, HPA057303, HPA068117, HPA069375" Enhanced Nucleoplasm NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 21: Non-specific - Transcription" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 23: Spermatids - Flagellum & Golgi organization" Nucleoplasm "HPA012035: AB_2668606, HPA057303: AB_2683406, HPA068117: AB_2685957, HPA069375: AB_2686131" "unprognostic (9.66e-2)" "unprognostic (5.29e-2)" "unprognostic (5.37e-2)" "unprognostic (2.70e-1)" "unprognostic (1.86e-1)" "unprognostic (1.66e-1)" "unprognostic (1.73e-2)" "unprognostic (7.76e-2)" "unprognostic (1.65e-2)" "unprognostic (6.29e-3)" "unprognostic (2.42e-1)" "unprognostic (5.93e-2)" "unprognostic (1.80e-2)" "unprognostic (9.96e-3)" "unprognostic (1.58e-1)" "unprognostic (9.64e-2)" "unprognostic (2.02e-1)" 4.7 4.3 2.3 3.7 5.0 2.7 5.4 7.0 4.5 6.8 1.9 3.2 2.4 6.3 4.6 3.4 4.0 3.7 4.6 3.1 5.4 4.7 4.9 4.9 4.0 5.6 4.2 6.0 4.3 5.5 3.2 6.3 5.7 4.3 3.1 5.2 4.2 3.9 4.6 4.1 3.1 4.1 3.6 5.6 3.7 3.1 4.7 3.9 7.6 3.3 3.6 3.2 3.9 10.5 6.7 6.7 4.1 5.3 5.3 10.5 3.5 12.5 8.8 9.5 9.8 4.3 5.2 6.9 10.0 8.3 6.2 2.5 3.8 4.3 11.4 7.6 4.5 6.3 5.7 2.1 10.1 4.0 4.9 5.0 5.1 7.7 5.3 7.6 8.0 4.4 5.6 3.9 9.1 0.5 7.9 3.2 1.5 0.7 3.9 3.3 10.6 4.8 5.7 2.2 4.1 4.6 9.4 2.5 3.4 2.8 3.7 3.8 10.4 6.9 3.6 3.3 7.2 4.5 4.4 6.0 4.6 6.2 12.2 5.8 5.3 2.7 2.4 6.0 2.0 5.1 2.6 3.0 4.8 4.1 3.2 2.2 4.6 3.9 11.5 5.8 3.4 2.0 2.3 5.0 7.0 4.5 3.1 5.4 5.6 4.2 5.7 3.6 4.7 10.5 45.8 32.1 44.6 65.6 36.3 14.7 21.8 22.1 20.5 32.9 19.5 15.0 21.8 24.3 26.1 29.5 20.9 17.3 37.5 8.3 23.5 20.3 236.8 19.5 32.1 34.4 14.9 29.2 63.5 15.8 13.0 33.7 17.3 21.0 51.9 33.8 57.1 25.0 21.8 65.6 60.0 11.3 24.4 39.2 25.0 58.7 37.6 33.3 23.2 73.1 55.8 19.6 25.7 84.4 159.6 19.1 15.1 38.4 26.4 14.6 17.8 21.2 20.8 38.8 6.6 38.5 27.8 61.3 23.6 14.5 12.9 6.7 27.6 48.8 12.2 11.6 POLL ENSG00000166169 "DNA polymerase lambda" Q9UGP5 10 101578882-101588270 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, DNA replication, DNA synthesis" "DNA-binding, DNA-directed DNA polymerase, Lyase, Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA076828 Supported Nucleoplasm "Intracellular and membrane" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 22: Non-specific - Unknown function" "Cluster 6: T47d - Mammary gland" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm "HPA076828: " "unprognostic (3.71e-3)" "unprognostic (6.93e-3)" "unprognostic (1.73e-2)" "unprognostic (2.47e-2)" "unprognostic (9.52e-2)" "unprognostic (1.80e-2)" "unprognostic (2.11e-2)" "unprognostic (1.24e-1)" "unprognostic (8.11e-2)" "unprognostic (1.71e-2)" "unprognostic (1.12e-2)" "unprognostic (7.19e-2)" "unprognostic (4.74e-2)" "unprognostic (1.06e-2)" "unprognostic (1.94e-1)" "unprognostic (3.86e-1)" "unprognostic (1.64e-3)" 17.4 22.4 17.3 12.4 18.0 12.8 19.6 15.9 19.0 21.1 18.2 21.8 16.8 19.4 22.6 18.1 22.1 15.6 19.9 17.5 16.0 24.8 26.9 15.6 17.0 16.3 16.3 26.3 45.6 21.3 28.5 13.7 17.2 26.0 17.1 17.4 20.8 15.4 34.4 16.1 18.7 14.2 14.1 22.7 27.6 41.4 17.1 7.4 26.1 18.2 17.1 20.9 17.7 17.4 23.5 21.0 16.2 23.0 16.2 30.0 22.7 15.3 26.4 22.9 23.9 15.5 27.8 5.7 23.5 13.9 12.6 28.8 18.4 22.6 18.4 20.8 24.8 18.1 23.1 17.7 29.8 19.0 16.2 27.5 30.3 25.0 51.8 64.1 24.7 11.1 20.4 19.2 14.7 18.8 0.0 20.8 8.6 13.0 12.4 0.1 14.6 9.9 19.2 14.1 11.2 16.6 9.4 15.7 26.5 23.8 47.3 11.0 13.5 8.1 16.4 9.8 16.8 28.4 15.3 8.9 17.5 16.6 6.3 0.6 9.2 1.3 6.5 6.6 10.6 8.4 7.4 6.8 11.6 6.8 11.7 8.0 1.0 9.5 6.7 0.2 10.2 7.6 17.3 18.0 15.9 19.0 17.5 16.0 16.3 16.3 17.2 14.1 17.1 17.4 7.5 6.4 12.9 13.7 11.4 3.7 6.7 9.7 7.4 16.9 14.7 19.0 8.6 11.5 7.4 7.3 47.9 16.9 7.5 9.1 5.9 9.6 25.2 7.3 7.5 7.6 13.1 25.9 10.4 21.5 9.8 9.6 20.9 6.6 14.0 20.9 8.6 10.9 11.2 21.9 7.9 13.6 18.3 17.7 6.0 51.6 14.0 9.6 10.6 2.8 18.0 10.1 13.4 8.5 9.9 13.7 9.2 11.3 10.9 6.5 13.7 11.6 7.2 24.0 13.1 10.8 9.6 35.5 11.0 8.4 2.0 11.5 9.4 14.4 15.6 5.6 POLM Tdt-N ENSG00000122678 "DNA polymerase mu" Q9NP87 7 44072062-44082530 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA recombination, DNA repair" "DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Rod photoreceptor cells: 48.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 63.0" "Lineage enriched" "Detected in all" 6 "granulocytes: 63.0" "Cell line enhanced" "Detected in all" "HBEC3-KT: 67.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA058900, HPA066007" Approved Nucleoplasm NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 72: Non-specific - Transcription" "Cluster 30: Epithelial cell lines - Translation" "Cluster 52: Non-specific - Transcription" Nucleoplasm "HPA058900: AB_2683848, HPA066007: AB_2685595" "unprognostic (2.44e-2)" "unprognostic (8.18e-2)" "unprognostic (2.21e-3)" "unprognostic (3.93e-2)" "unprognostic (5.40e-2)" "unprognostic (1.83e-1)" "unprognostic (2.75e-1)" "unprognostic (1.22e-1)" "unprognostic (5.12e-2)" "unprognostic (3.91e-1)" "unprognostic (9.36e-2)" "unprognostic (8.26e-2)" "unprognostic (2.46e-3)" "unprognostic (6.31e-2)" "unprognostic (1.47e-1)" "unprognostic (2.87e-1)" "unprognostic (3.87e-3)" 8.0 5.9 4.0 4.4 4.0 4.5 7.8 4.4 4.1 8.8 4.0 6.6 5.6 6.1 3.7 8.4 6.4 4.4 7.5 3.5 3.7 10.2 9.7 5.9 7.6 4.4 5.2 8.9 8.5 4.4 6.0 2.8 4.5 8.4 3.4 4.3 7.5 6.7 7.9 8.9 9.0 3.5 3.9 13.1 9.1 3.8 5.1 9.8 10.5 4.9 7.2 7.6 7.8 4.0 1.8 2.5 2.6 5.8 3.6 4.2 7.5 6.1 6.2 4.5 2.5 3.2 4.2 18.1 5.6 4.7 5.5 5.3 2.7 67.0 2.6 6.3 6.0 2.3 2.8 1.1 4.8 5.8 7.7 6.1 6.0 3.7 4.4 8.6 8.1 18.5 2.7 9.2 3.8 4.1 10.5 4.7 5.4 5.5 14.2 9.6 1.6 7.3 4.7 2.9 2.7 4.8 2.9 11.3 5.6 4.0 6.7 10.2 5.7 3.1 4.4 3.2 8.6 14.1 7.5 13.9 5.6 5.2 6.9 23.9 3.5 10.7 6.3 4.3 6.5 7.9 5.5 5.6 3.3 11.1 7.9 6.3 63.0 7.4 3.3 9.5 5.8 2.9 4.0 4.0 4.4 4.1 3.5 3.7 4.4 5.2 4.5 3.9 5.1 4.0 8.3 3.2 7.8 13.1 33.4 4.5 11.2 8.3 11.4 24.5 10.3 6.2 5.6 15.7 11.4 12.9 29.2 12.3 19.9 11.1 1.9 7.6 0.6 5.0 7.1 8.7 5.4 3.0 4.0 9.4 9.4 7.1 27.5 6.0 24.1 11.1 12.5 9.2 10.2 18.5 4.3 8.5 10.2 11.1 5.0 0.7 14.0 9.9 10.6 6.5 14.4 11.9 23.7 3.5 5.7 8.3 22.5 10.1 15.6 16.6 19.4 5.6 7.4 48.3 0.0 6.9 9.0 17.5 14.3 6.5 5.1 9.7 18.8 13.5 12.1 15.0 POLN ENSG00000130997 "DNA polymerase nu" Q7Z5Q5 4 2071918-2242121 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, DNA replication" "DNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "adipose tissue: 2.4;testis: 2.6" "Cell type enhanced" "Detected in many" "Astrocytes: 32.3;Excitatory neurons: 77.7;Inhibitory neurons: 42.7;Oligodendrocyte precursor cells: 22.1;Oligodendrocytes: 26.8;Spermatocytes: 23.4" "Low cancer specificity" "Detected in single" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "ASC diff: 1.7" "Not detected" "Not detected" "Not detected" "Not detected" "HPA035939, HPA035940" Enhanced Nucleoplasm NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 71: Testis - DNA repair" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "HPA035939: AB_2674875, HPA035940: AB_2674876" "unprognostic (8.52e-3)" "unprognostic (1.55e-1)" "unprognostic (4.87e-2)" "unprognostic (1.32e-1)" "unprognostic (2.53e-1)" "unprognostic (1.45e-2)" "unprognostic (3.46e-1)" "unprognostic (2.70e-1)" "unprognostic (5.83e-2)" "unprognostic (2.23e-1)" "unprognostic (2.02e-3)" "unprognostic (1.25e-1)" "unprognostic (1.49e-3)" "unprognostic (9.14e-2)" "unprognostic (2.67e-1)" "unprognostic (2.66e-1)" "unprognostic (1.82e-2)" 2.4 0.6 0.3 0.0 0.4 0.0 1.0 0.2 0.5 0.3 0.0 0.3 0.1 0.3 0.7 0.1 0.4 0.3 0.3 0.3 0.0 0.4 0.4 0.2 0.2 0.0 0.0 0.2 0.4 0.1 0.4 0.1 0.0 0.6 0.0 0.2 0.5 0.2 0.4 0.3 0.3 0.1 0.0 0.3 0.3 2.6 0.1 0.1 0.3 0.1 0.1 0.2 0.2 0.4 0.0 0.6 0.0 0.3 1.7 0.5 0.0 0.1 0.1 0.0 0.3 0.0 0.0 0.3 0.0 0.4 0.0 0.0 0.5 0.0 0.1 0.0 0.5 0.0 0.4 0.0 0.0 0.0 0.2 0.7 0.2 0.3 0.2 0.5 0.1 0.0 0.0 0.2 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.2 0.1 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.4 0.2 0.5 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.4 2.4 0.0 0.0 32.3 1.0 0.9 1.0 0.6 0.6 4.2 3.0 1.5 3.6 1.5 1.7 0.0 0.0 0.2 0.6 0.2 3.9 0.4 8.3 4.2 2.0 1.9 4.8 0.8 77.7 1.0 0.3 2.0 1.5 2.1 0.0 5.5 3.3 1.1 0.7 3.3 42.7 0.0 2.0 1.3 1.0 14.1 4.4 1.3 0.0 15.0 0.7 2.5 1.0 22.1 26.8 0.5 1.1 3.8 1.5 1.0 0.3 0.8 1.9 3.8 0.0 2.9 1.1 23.4 10.4 0.5 1.6 0.0 1.8 4.1 0.3 1.3 POLQ POLH ENSG00000051341 "DNA polymerase theta" O75417 3 121431427-121546641 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair" "DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "bone marrow: 6.0;lymphoid tissue: 4.5" "Cell type enhanced" "Detected in many" "Erythroid cells: 16.4;Excitatory neurons: 9.5;Granulosa cells: 12.6;Inhibitory neurons: 7.8;Plasma cells: 12.2" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in single" "cerebellum: 1.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Not detected" "Not detected" "Region enhanced" "Detected in single" "cerebellum: 2.5" HPA053359 Supported "Nucleoplasm,Golgi apparatus,Cytosol" NA Yes "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "Golgi apparatus, Cytosol" "HPA053359: " "unprognostic (1.59e-1)" "unprognostic (4.18e-2)" "unprognostic (2.66e-2)" "prognostic unfavorable (5.46e-5)" "unprognostic (2.70e-1)" "unprognostic (6.23e-3)" "unprognostic (3.09e-5)" "unprognostic (8.55e-3)" "unprognostic (1.09e-4)" "unprognostic (2.86e-1)" "unprognostic (5.59e-5)" "unprognostic (2.06e-3)" "unprognostic (0.00e+0)" "prognostic favorable (1.04e-4)" "unprognostic (1.76e-1)" "unprognostic (6.01e-2)" "unprognostic (5.76e-2)" 0.1 0.2 0.0 1.6 0.1 6.0 0.4 1.0 0.2 0.2 0.0 1.2 1.2 0.2 0.0 2.0 0.0 0.1 0.2 0.2 0.0 0.0 0.1 0.2 2.8 0.0 0.0 0.0 0.0 0.1 0.0 1.0 0.0 0.1 2.0 0.0 0.3 0.0 0.0 1.4 0.9 0.4 0.0 0.8 0.5 2.2 0.0 4.5 0.0 0.0 2.3 0.3 0.5 0.0 18.2 12.1 10.2 7.2 0.9 1.2 9.2 8.5 3.2 9.7 12.9 9.8 6.6 21.5 3.7 4.6 11.7 14.0 12.2 5.4 16.4 6.3 6.7 13.8 8.0 6.1 0.1 15.1 12.1 0.2 0.4 8.9 5.4 1.7 4.9 7.9 9.3 15.9 10.3 7.1 13.7 8.8 9.7 5.5 5.9 11.4 12.2 7.6 3.1 10.3 5.5 5.0 9.8 5.2 3.4 8.8 4.8 14.8 3.8 8.6 11.2 3.4 11.1 8.0 6.9 21.8 4.1 11.0 6.4 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 1.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.5 1.6 0.7 0.9 0.5 0.6 0.0 0.9 0.6 0.6 1.6 0.0 2.0 0.0 0.0 3.1 0.6 1.6 0.0 0.1 0.4 0.9 1.0 0.5 0.0 16.4 9.5 0.0 3.3 1.2 4.6 1.0 0.0 12.6 0.0 0.2 2.3 0.0 7.8 1.6 2.0 1.3 1.2 0.7 0.3 1.7 0.0 1.0 0.6 0.4 0.0 1.5 1.3 0.2 1.2 0.0 12.2 0.5 0.2 0.1 2.4 0.2 0.0 0.1 1.0 6.8 3.4 4.9 0.1 0.3 1.8 0.9 3.2 0.8 POLR1A "DKFZP586M0122, FLJ21915, RPA1, RPA190, RPO1-4" ENSG00000068654 "RNA polymerase I subunit A" O95602 2 86020216-86106155 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RNA polymerase related proteins" Transcription "Nucleotidyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010145, HPA031513, HPA049700" Supported Enhanced "Nucleoplasm,Nucleoli fibrillar center,Intermediate filaments" No No "Cluster 7: Monocytes - Unknown function" "Cluster 52: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 59: Non-specific - Transcription" "Nucleoli fibrillar center" "Nucleoplasm, Intermediate filaments" "CAB010145: AB_675814, HPA031513: AB_2673916, HPA049700: AB_2680856" "unprognostic (1.22e-1)" "unprognostic (1.82e-2)" "unprognostic (1.55e-1)" "unprognostic (2.46e-2)" "unprognostic (1.32e-1)" "unprognostic (1.93e-1)" "prognostic unfavorable (3.70e-9)" "unprognostic (1.06e-2)" "unprognostic (1.35e-1)" "prognostic unfavorable (3.37e-4)" "unprognostic (4.31e-2)" "unprognostic (4.56e-2)" "unprognostic (3.27e-1)" "unprognostic (2.20e-3)" "unprognostic (1.94e-1)" "prognostic unfavorable (8.41e-4)" "unprognostic (7.20e-2)" 5.4 5.7 3.7 5.8 4.0 4.9 4.5 3.1 4.7 4.9 4.0 4.9 4.1 8.2 3.0 6.0 5.2 2.9 5.8 3.9 3.6 4.6 5.0 4.0 4.6 3.4 3.6 5.2 5.2 7.1 4.9 5.0 3.3 4.5 5.0 3.5 3.9 5.1 10.8 5.5 3.8 6.9 2.7 3.8 4.5 6.2 4.4 6.2 4.5 7.4 4.9 5.2 4.2 4.3 18.5 41.1 18.0 34.7 17.2 13.7 25.9 16.6 10.9 23.2 14.4 51.9 14.2 41.9 17.2 17.0 22.7 20.9 46.6 24.4 20.6 17.6 24.0 36.2 18.0 35.1 12.1 34.8 18.7 10.5 15.0 34.6 26.7 8.8 18.2 19.0 48.8 10.3 16.2 16.4 25.8 15.1 32.7 24.4 26.8 30.7 39.5 19.6 10.5 29.7 27.7 14.6 18.3 23.8 12.7 12.3 14.0 12.0 29.3 28.0 22.2 24.3 33.8 14.5 15.3 35.7 14.6 29.3 25.3 0.5 0.4 0.0 0.7 0.6 0.9 0.5 0.3 0.6 0.4 0.6 0.3 0.4 0.1 0.5 0.5 0.7 0.1 0.4 3.7 4.0 3.1 4.7 3.9 3.6 3.4 3.6 3.3 2.7 4.4 4.3 4.9 3.2 9.1 13.4 8.8 4.2 4.9 5.3 12.0 12.4 6.2 5.5 11.1 8.6 4.7 9.2 16.7 6.3 7.2 5.1 3.9 6.0 3.0 5.4 13.8 6.5 9.6 10.9 19.7 4.9 5.4 7.7 8.2 6.9 6.3 11.0 4.2 8.3 12.5 11.8 18.1 6.7 2.0 3.1 3.5 1.7 6.2 5.5 5.4 6.5 3.3 4.2 6.2 20.1 18.2 6.6 3.0 5.3 10.1 9.1 3.5 3.4 5.2 9.7 0.0 14.3 6.2 5.0 7.2 13.4 2.7 3.8 7.5 12.4 10.4 4.0 POLR1B "FLJ10816, FLJ21921, RPA135, RPA2, Rpo1-2" ENSG00000125630 "RNA polymerase I subunit B" Q9H9Y6 2 112541915-112579818 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RNA polymerase related proteins" Transcription "Nucleotidyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in many" 4 "Early spermatids: 181.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA037528 Supported "Nucleoli fibrillar center,Cytosol" NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 23: Spermatids - Flagellum & Golgi organization" "Nucleoli fibrillar center" Cytosol "HPA037528: AB_10671627" "unprognostic (1.66e-1)" "unprognostic (3.17e-2)" "unprognostic (2.55e-1)" "prognostic unfavorable (2.71e-5)" "unprognostic (2.07e-1)" "unprognostic (1.16e-2)" "unprognostic (1.98e-3)" "unprognostic (1.98e-1)" "unprognostic (2.05e-1)" "unprognostic (1.13e-1)" "prognostic unfavorable (5.52e-4)" "unprognostic (6.12e-2)" "unprognostic (1.29e-2)" "unprognostic (1.18e-1)" "unprognostic (2.19e-1)" "unprognostic (1.08e-1)" "unprognostic (3.56e-2)" 5.7 4.6 2.9 5.6 3.0 4.1 8.2 3.5 3.1 5.3 3.8 5.5 4.4 4.7 4.4 8.1 6.7 3.7 4.1 2.8 3.5 8.1 10.7 4.1 9.3 2.6 2.7 6.3 8.1 11.9 4.4 5.6 2.5 5.0 6.2 5.2 3.8 4.7 7.5 5.2 3.8 5.3 2.6 6.7 4.3 8.4 3.1 7.2 10.7 6.4 10.8 7.9 3.6 3.4 21.1 21.6 11.2 28.2 13.9 13.2 24.0 15.1 11.9 24.0 21.5 48.8 12.5 46.1 22.9 9.8 18.8 29.5 56.1 30.6 28.4 22.3 30.9 26.5 21.4 37.1 14.2 43.6 18.1 12.7 21.6 25.4 39.6 9.8 19.9 10.2 55.0 16.8 13.2 17.5 20.5 29.7 66.3 29.5 42.8 30.9 21.3 54.1 17.2 19.2 34.3 29.1 12.1 34.7 19.7 13.8 16.3 15.6 15.9 14.6 23.2 13.7 21.8 24.3 44.4 40.9 11.0 28.8 13.1 0.4 8.0 3.3 10.0 8.3 21.5 11.4 9.9 10.7 14.2 11.6 12.4 12.5 0.8 15.3 6.5 3.5 15.2 9.6 2.9 3.0 3.5 3.1 2.8 3.5 2.6 2.7 2.5 2.6 3.1 3.4 4.8 16.0 5.9 4.6 8.5 15.0 4.7 4.1 9.6 3.6 4.2 3.7 6.4 7.2 5.8 9.2 2.1 3.4 6.5 2.0 5.9 3.9 181.9 3.5 7.6 5.8 3.6 5.9 8.8 4.6 2.8 3.5 8.6 4.2 5.1 6.5 1.4 9.4 3.8 1.7 9.2 3.8 0.0 4.3 3.7 40.9 3.1 3.8 1.8 3.7 4.5 4.3 8.2 7.5 8.1 3.8 5.8 3.0 6.4 6.2 1.2 5.1 3.2 2.9 0.0 5.1 3.5 10.3 7.9 12.7 17.2 0.5 6.2 6.8 5.5 3.9 POLR2B RPB2 ENSG00000047315 "RNA polymerase II subunit B" P30876 4 56977722-57031158 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RNA polymerase related proteins" Transcription "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA037506 Approved Supported Nucleoplasm NA NA "Cluster 44: Non-specific - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 52: Non-specific - Transcription" Nucleoplasm "HPA037506: AB_10672597" "unprognostic (9.88e-3)" "unprognostic (4.38e-2)" "unprognostic (1.83e-3)" "unprognostic (7.51e-2)" "unprognostic (2.30e-2)" "unprognostic (4.21e-3)" "unprognostic (1.24e-3)" "unprognostic (3.51e-1)" "unprognostic (6.39e-2)" "unprognostic (1.22e-1)" "unprognostic (1.23e-1)" "unprognostic (1.95e-1)" "prognostic favorable (7.17e-4)" "unprognostic (1.91e-1)" "unprognostic (1.51e-1)" "unprognostic (3.43e-1)" "unprognostic (7.35e-2)" 28.2 29.1 11.8 38.3 14.0 34.1 34.1 21.0 17.6 32.9 16.9 34.7 32.6 34.9 26.5 30.0 32.9 30.2 48.1 14.2 16.0 35.7 30.0 27.7 49.9 14.1 11.8 31.6 28.3 50.3 17.8 32.9 15.4 32.5 36.3 36.8 30.6 32.4 64.7 28.0 30.9 38.3 12.8 36.5 31.1 39.8 12.8 61.2 37.6 56.7 51.3 42.4 19.8 17.6 78.9 64.3 110.5 98.2 89.3 80.3 61.2 94.6 101.3 98.3 91.1 82.9 80.1 126.5 86.1 94.3 71.4 52.2 140.5 77.2 139.8 54.2 66.3 96.9 70.0 71.5 102.2 156.0 100.6 86.8 76.1 114.3 68.5 81.0 119.5 95.0 145.4 100.0 115.9 56.8 142.3 60.5 92.0 101.5 77.9 105.9 75.7 68.4 66.8 90.7 95.3 106.8 67.5 120.3 89.6 90.7 65.8 88.3 91.2 74.4 95.2 75.8 132.2 77.3 75.5 172.8 82.4 83.1 92.4 51.9 17.0 22.8 27.7 17.0 29.5 27.9 26.6 28.8 22.2 18.9 25.9 30.8 14.4 26.5 19.8 17.6 30.9 19.8 11.8 14.0 21.0 17.6 14.2 16.0 14.1 11.8 15.4 12.8 12.8 17.6 39.5 28.9 52.0 26.8 61.5 41.3 60.9 60.3 39.9 45.5 31.5 26.5 35.7 35.8 56.3 36.8 43.8 49.2 77.1 36.9 19.6 60.9 5.9 53.4 52.7 39.5 29.9 50.5 31.1 55.0 30.7 42.8 59.1 45.8 58.2 36.8 30.7 30.8 29.1 45.4 32.0 36.9 50.8 45.8 36.8 8.8 57.5 42.5 44.4 33.7 74.3 26.7 115.4 23.6 40.4 54.0 36.2 38.0 50.5 59.4 36.6 32.7 80.6 49.0 72.3 46.5 45.7 74.0 63.6 32.7 39.9 41.0 75.2 46.2 35.4 74.6 POLR3A "C160, hRPC155, RPC1, RPC155" ENSG00000148606 "RNA polymerase III subunit A" O14802 10 77969251-78029515 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RNA polymerase related proteins" "Antiviral defense, Immunity, Innate immunity, Transcription" "Nucleotidyltransferase, Transferase" "Disease variant, Leukodystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 64.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "PC-3: 75.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA037926 Uncertain Supported Nucleoplasm NA NA "Cluster 42: Non-specific - Transcription" "Cluster 58: Brain - Synaptic function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 9: Photoreceptor cells - Phototransduction" Nucleoplasm "HPA037926: AB_10672400" "unprognostic (6.83e-2)" "unprognostic (3.41e-2)" "unprognostic (4.54e-2)" "unprognostic (2.76e-2)" "unprognostic (6.41e-2)" "unprognostic (1.75e-1)" "prognostic unfavorable (3.64e-6)" "unprognostic (3.25e-1)" "unprognostic (1.07e-1)" "unprognostic (1.73e-1)" "unprognostic (6.64e-2)" "unprognostic (2.09e-2)" "unprognostic (1.51e-2)" "unprognostic (1.34e-1)" "unprognostic (3.19e-1)" "unprognostic (1.30e-1)" "unprognostic (4.11e-2)" 4.3 6.0 6.6 5.2 7.1 3.9 6.2 6.7 7.9 5.1 4.7 4.8 5.1 5.5 7.5 5.0 4.8 3.7 4.9 8.1 3.7 5.2 5.6 4.0 5.7 5.5 3.4 6.5 5.4 6.8 10.4 6.1 5.5 5.8 5.7 12.8 5.0 4.5 11.5 6.7 4.7 5.6 2.2 5.1 4.7 6.0 4.0 7.6 5.6 8.7 6.3 5.0 4.8 6.5 14.2 16.3 17.4 28.8 11.2 14.2 11.6 16.0 20.7 20.2 19.8 22.1 10.0 17.6 9.7 14.0 11.5 15.7 30.3 17.5 24.4 13.0 22.2 14.2 13.6 26.6 10.5 24.6 11.5 12.2 12.3 35.9 33.0 19.4 18.0 14.1 26.8 10.6 19.9 10.6 18.7 15.6 19.0 11.0 75.1 17.5 11.0 11.5 10.0 8.6 15.5 20.0 15.4 28.3 16.6 15.5 21.0 12.7 19.8 12.9 12.5 14.2 32.0 16.4 18.6 21.0 23.0 25.4 6.4 5.4 2.6 1.5 3.5 3.1 3.5 2.6 2.8 3.4 2.4 3.2 2.5 3.0 1.5 3.4 2.9 2.6 4.6 1.9 6.6 7.1 6.7 7.9 8.1 3.7 5.5 3.4 5.5 2.2 4.0 6.5 8.5 0.0 9.1 17.0 8.7 9.9 5.1 5.3 11.4 28.3 9.6 8.3 11.7 8.6 9.5 0.0 64.6 8.0 12.6 6.1 1.9 7.0 1.6 8.3 14.4 8.1 7.2 11.6 26.4 6.2 6.9 8.2 8.2 8.9 6.3 15.7 5.3 9.5 5.5 15.2 26.3 10.2 0.0 6.9 3.7 1.2 13.1 5.9 1.8 10.3 7.8 13.0 12.3 16.1 18.7 8.1 8.3 8.2 11.2 4.7 8.0 5.0 10.4 31.5 6.6 13.6 8.3 12.5 18.0 10.1 9.1 4.1 7.8 13.7 8.6 3.6 POLR3B "C128, FLJ10388, RPC2" ENSG00000013503 "RNA polymerase III subunit B" Q9NW08 12 106357748-106510198 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RNA polymerase related proteins" "Antiviral defense, Immunity, Innate immunity, Transcription" "Nucleotidyltransferase, Transferase" "Disease variant, Leukodystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Inhibitory neurons: 24.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036466 Supported Approved "Nuclear speckles" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 59: Non-specific - Transcription" "Nuclear speckles" "HPA036466: AB_10671842" "unprognostic (1.17e-1)" "unprognostic (1.52e-1)" "unprognostic (4.80e-2)" "unprognostic (1.37e-2)" "unprognostic (1.13e-1)" "unprognostic (2.73e-1)" "unprognostic (4.21e-2)" "unprognostic (1.12e-1)" "unprognostic (1.33e-1)" "unprognostic (3.36e-2)" "unprognostic (6.11e-2)" "unprognostic (5.09e-2)" "prognostic favorable (1.21e-4)" "unprognostic (1.54e-1)" "unprognostic (1.46e-1)" "unprognostic (8.73e-2)" "unprognostic (9.24e-2)" 4.5 8.7 3.1 4.8 4.4 5.2 5.0 4.3 4.6 4.7 3.7 5.3 4.2 4.6 5.2 8.6 5.1 3.6 5.8 3.4 2.9 6.8 9.0 4.7 4.1 2.2 2.3 7.5 4.9 11.1 2.4 6.7 2.3 5.6 5.7 6.2 4.7 4.0 6.5 11.0 3.4 5.4 2.7 3.3 5.4 6.1 3.2 4.7 6.0 8.3 5.6 4.9 4.3 3.6 16.2 7.6 16.4 7.8 13.9 13.1 22.9 21.9 13.0 15.2 11.6 14.0 4.4 20.6 7.7 14.2 5.6 14.8 19.5 19.2 18.5 16.6 13.1 15.7 10.1 12.0 9.2 26.1 17.0 11.7 13.4 15.1 17.3 10.3 11.5 9.8 24.5 6.5 11.2 12.0 19.1 8.7 17.8 11.9 28.5 11.6 9.8 13.5 8.6 21.8 17.3 9.6 13.6 18.2 13.4 10.8 17.0 7.9 11.0 8.3 10.0 13.6 13.1 8.1 22.4 30.3 3.8 15.9 9.2 5.6 2.0 1.5 2.0 2.2 2.7 2.1 2.2 2.2 2.6 1.3 3.0 1.9 1.3 2.1 2.2 0.9 2.7 1.7 3.1 4.4 4.3 4.6 3.4 2.9 2.2 2.3 2.3 2.7 3.2 3.6 2.4 0.0 9.2 14.4 4.7 1.8 1.7 4.5 4.6 6.0 3.4 3.7 10.3 2.8 7.0 5.5 6.2 11.0 3.8 3.8 1.9 5.1 7.1 3.9 7.0 3.3 4.2 3.8 22.3 4.6 9.3 4.4 9.2 3.9 5.1 4.8 3.6 11.0 3.1 3.3 24.1 5.6 2.0 1.6 0.3 5.2 3.7 2.4 3.6 9.4 1.0 2.4 2.1 17.1 22.4 3.8 1.1 4.9 4.9 1.5 1.7 3.4 7.2 7.2 6.6 6.9 4.1 16.5 10.9 8.9 3.0 7.4 4.1 7.2 5.1 1.2 POLRMT "APOLMT, h-mtRPOL, MTRNAP, MTRPOL" ENSG00000099821 "RNA polymerase mitochondrial" O00411 19 617221-633537 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transcription "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 84.0;Spermatogonia: 84.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006366 Uncertain Supported Mitochondria NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 21: Non-specific - Transcription" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" Mitochondria "HPA006366: AB_1079654" "unprognostic (3.24e-1)" "unprognostic (4.31e-2)" "unprognostic (7.96e-2)" "prognostic favorable (4.50e-4)" "unprognostic (9.46e-2)" "unprognostic (2.94e-2)" "unprognostic (3.04e-2)" "unprognostic (9.41e-2)" "unprognostic (1.45e-1)" "unprognostic (3.48e-1)" "unprognostic (7.64e-3)" "unprognostic (1.81e-2)" "unprognostic (1.62e-1)" "unprognostic (1.28e-3)" "unprognostic (1.66e-1)" "unprognostic (2.92e-1)" "unprognostic (1.01e-1)" 17.2 23.9 19.5 9.1 20.5 6.8 18.1 20.7 28.5 19.3 16.9 22.3 14.5 19.7 10.0 21.0 19.2 5.3 38.0 20.1 17.5 26.2 41.3 16.0 9.6 24.4 20.4 20.7 26.3 11.4 22.7 5.0 21.3 20.7 7.2 5.7 17.2 9.2 69.2 27.9 23.9 6.6 17.8 22.5 21.8 66.6 20.9 11.0 20.1 14.9 7.5 21.5 17.7 24.4 24.5 43.6 9.7 42.1 19.7 11.0 35.7 11.1 12.9 15.7 14.5 44.2 15.9 24.9 22.0 10.2 7.9 24.5 35.5 21.0 11.8 28.3 86.8 19.3 26.4 56.9 20.5 32.6 34.7 10.7 29.3 16.4 19.7 11.3 22.9 34.0 37.3 23.6 14.8 34.3 43.7 44.7 38.4 31.1 30.2 42.0 13.3 42.4 21.4 20.7 30.7 22.1 10.2 26.7 28.4 10.3 15.4 29.9 14.1 17.2 22.0 26.9 33.3 57.4 51.0 38.7 36.9 27.3 21.8 0.0 2.9 2.5 6.2 3.8 5.0 5.6 4.6 4.6 5.5 6.3 3.9 4.5 0.5 6.0 4.2 5.4 3.1 4.6 19.5 20.5 20.7 28.5 20.1 17.5 24.4 20.4 21.3 17.8 20.9 24.4 10.3 12.8 11.5 2.6 14.2 8.0 6.1 5.8 10.2 18.3 9.1 8.0 18.0 15.7 7.9 16.5 18.8 15.5 13.3 31.5 7.9 6.7 39.8 7.7 6.1 9.7 13.1 9.4 2.7 8.0 8.7 8.9 14.3 8.6 12.7 15.1 8.2 21.9 10.4 11.8 2.7 12.7 4.1 8.3 7.4 84.0 12.5 8.0 10.6 3.7 7.4 8.4 18.6 1.5 4.6 6.5 12.4 13.2 7.8 10.3 26.0 15.1 6.4 18.1 6.6 8.9 10.0 31.6 84.9 10.6 7.2 7.7 12.7 15.6 24.4 6.2 POMGNT2 "AGO61, C3orf39, FLJ14566, GTDC2" ENSG00000144647 "Protein O-linked mannose N-acetylglucosaminyltransferase 2 (beta 1,4-)" Q8NAT1 3 43079232-43106079 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Congenital muscular dystrophy, Disease variant, Dystroglycanopathy, Limb-girdle muscular dystrophy, Lissencephaly" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034870, HPA040989" Uncertain "Intracellular and membrane" NA NA "Cluster 35: T-regs - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 33: Fibroblasts - ECM organization" "HPA034870: AB_10602701, HPA040989: AB_2677238" "unprognostic (2.37e-3)" "unprognostic (8.22e-2)" "prognostic favorable (8.13e-5)" "unprognostic (2.57e-2)" "unprognostic (4.17e-2)" "unprognostic (1.96e-1)" "prognostic unfavorable (1.26e-5)" "unprognostic (8.71e-2)" "unprognostic (1.73e-2)" "unprognostic (7.43e-2)" "unprognostic (1.95e-2)" "unprognostic (4.01e-1)" "prognostic favorable (4.00e-7)" "unprognostic (4.98e-2)" "unprognostic (1.55e-1)" "unprognostic (3.26e-1)" "unprognostic (2.57e-1)" 11.0 13.5 22.1 4.2 21.0 20.7 9.9 22.6 23.1 19.4 19.8 14.9 3.6 50.7 11.3 7.5 30.9 9.0 19.1 22.6 20.8 12.8 9.2 10.2 3.1 21.7 21.0 30.4 15.3 17.7 19.1 5.5 24.9 15.2 2.9 9.0 13.8 14.5 31.5 11.7 7.1 19.7 18.1 6.0 13.8 14.8 26.7 5.5 11.8 18.6 2.3 15.2 13.6 17.8 20.0 14.9 8.5 26.0 32.0 8.2 13.5 5.6 10.0 19.5 22.7 18.2 13.7 0.0 20.6 10.2 23.6 0.4 14.0 16.3 8.5 0.1 39.2 14.0 11.1 17.4 12.1 9.9 15.9 9.5 11.9 13.2 7.7 7.7 7.6 29.7 11.6 0.1 7.6 11.8 18.1 2.6 18.7 12.4 27.7 7.0 6.0 12.3 11.6 14.4 13.4 12.2 11.8 9.4 10.9 5.7 17.8 8.6 3.6 15.7 21.9 23.3 23.3 14.5 23.2 0.1 20.2 19.6 17.0 0.0 0.5 0.5 3.0 0.4 2.7 1.9 1.9 1.9 0.6 0.9 2.3 1.9 0.0 1.0 0.4 0.6 1.7 1.0 22.1 21.0 22.6 23.1 22.6 20.8 21.7 21.0 24.9 18.1 26.7 17.8 4.1 3.2 2.0 11.8 2.6 8.0 2.8 3.8 6.8 15.3 8.2 7.5 17.0 10.0 3.4 14.7 8.4 3.4 3.2 2.4 5.9 9.9 10.4 6.9 6.6 3.9 6.0 28.4 13.2 10.7 5.3 14.3 4.6 2.5 0.0 12.6 5.0 6.6 6.2 10.1 14.1 1.9 4.1 4.2 4.8 24.5 19.9 3.7 5.4 3.7 1.1 10.1 5.2 15.6 7.4 5.5 2.0 29.3 3.1 4.4 1.4 5.2 9.2 5.2 13.1 8.5 8.3 10.0 19.0 6.0 11.6 1.8 3.6 3.2 2.7 2.2 POMK "FLJ23356, SgK196" ENSG00000185900 "Protein O-mannose kinase" Q9H5K3 8 43093498-43131180 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Transferase" "Congenital muscular dystrophy, Disease variant, Dystroglycanopathy, Limb-girdle muscular dystrophy, Lissencephaly" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 14.5" "Cell type enhanced" "Detected in some" "Excitatory neurons: 6.9;Inhibitory neurons: 6.8;Microglial cells: 7.5;Oligodendrocyte precursor cells: 5.5;Oligodendrocytes: 6.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA013321 Uncertain NA NA "Cluster 17: Basophils - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 59: Non-specific - Transcription" "HPA013321: AB_2668809" "unprognostic (1.66e-2)" "unprognostic (1.12e-2)" "unprognostic (1.27e-1)" "unprognostic (4.37e-2)" "unprognostic (1.29e-1)" "unprognostic (4.62e-2)" "unprognostic (5.56e-2)" "unprognostic (2.42e-1)" "unprognostic (2.50e-1)" "unprognostic (8.10e-2)" "unprognostic (1.23e-3)" "unprognostic (1.03e-1)" "unprognostic (2.32e-1)" "unprognostic (7.09e-2)" "unprognostic (1.06e-1)" "unprognostic (3.71e-3)" "unprognostic (2.10e-2)" 2.3 2.8 11.6 2.5 12.6 6.8 3.8 6.0 14.5 4.1 0.0 3.3 1.6 2.3 7.2 1.9 2.4 1.9 1.3 12.3 7.9 2.0 3.3 2.6 4.0 8.8 7.6 2.6 3.3 2.6 0.9 3.1 9.1 5.0 3.6 5.9 2.4 2.4 2.8 5.8 1.8 2.6 6.1 3.9 3.2 3.6 11.1 4.9 3.1 2.7 4.1 2.7 0.8 8.8 7.8 9.1 9.2 24.4 8.8 6.6 9.1 4.3 4.7 6.1 6.1 8.4 13.8 9.2 7.7 7.1 2.5 8.2 13.5 11.7 7.9 2.0 4.3 19.2 6.2 15.6 8.3 6.1 9.9 8.7 15.2 11.1 10.8 4.6 9.1 10.1 4.6 15.9 9.7 5.3 14.5 18.6 19.8 11.2 1.7 8.7 10.2 4.1 19.1 11.3 6.5 8.2 12.4 7.5 10.0 10.7 14.9 9.6 9.8 11.6 12.8 11.8 8.1 5.8 11.6 11.7 5.7 6.3 16.0 2.2 0.9 0.8 0.8 0.8 0.9 0.5 0.8 0.8 1.4 1.2 1.0 1.1 2.8 0.9 1.5 2.4 1.2 0.6 11.6 12.6 6.0 14.5 12.3 7.9 8.8 7.6 9.1 6.1 11.1 8.8 0.6 0.0 0.5 2.9 0.7 0.4 0.1 0.3 1.8 1.6 0.3 0.3 0.3 0.0 1.3 0.0 0.0 0.4 1.0 0.5 0.0 0.2 0.0 0.7 1.9 0.3 0.0 0.4 6.9 0.0 0.8 0.6 1.5 1.0 0.0 1.2 0.0 0.3 0.2 0.0 6.8 0.3 0.0 0.3 0.0 0.0 0.6 0.8 1.8 7.5 1.3 0.3 2.1 5.5 6.5 0.2 0.0 0.0 1.5 0.2 0.5 0.1 0.0 1.0 0.0 0.2 0.6 0.3 1.1 2.3 0.1 0.5 0.9 0.6 0.5 0.2 POMT1 LGMD2K ENSG00000130714 "Protein O-mannosyltransferase 1" Q9Y6A1 9 131502789-131523806 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Congenital muscular dystrophy, Disease variant, Dystroglycanopathy, Limb-girdle muscular dystrophy, Lissencephaly" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 64.5;Spermatocytes: 71.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA065252 Uncertain "Golgi apparatus" NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 43: Testis - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" "Golgi apparatus" "HPA065252: AB_2685445" "unprognostic (2.00e-3)" "unprognostic (2.02e-1)" "unprognostic (1.60e-1)" "unprognostic (5.09e-3)" "unprognostic (1.67e-1)" "unprognostic (7.97e-2)" "unprognostic (5.35e-3)" "unprognostic (1.14e-1)" "unprognostic (9.76e-3)" "unprognostic (2.84e-1)" "prognostic favorable (3.90e-5)" "unprognostic (8.36e-2)" "prognostic favorable (4.68e-5)" "unprognostic (2.41e-2)" "unprognostic (1.61e-1)" "unprognostic (4.72e-2)" "unprognostic (2.12e-1)" 15.7 20.9 16.6 7.6 16.7 6.6 16.2 18.4 21.0 21.1 15.0 24.8 9.0 17.1 7.2 15.2 18.4 9.3 24.5 25.5 16.0 25.5 24.4 15.6 8.3 16.0 16.2 25.6 25.9 15.5 31.3 9.7 16.5 28.4 6.5 8.1 20.1 8.7 32.9 17.5 19.9 7.1 14.2 22.2 20.4 63.7 16.9 7.1 19.0 13.4 5.4 16.5 17.1 15.5 9.8 17.4 10.5 26.4 19.3 13.5 24.5 12.1 17.0 21.3 14.1 15.8 14.7 2.5 16.9 26.4 8.6 24.1 17.3 16.6 5.9 16.2 21.6 4.2 28.5 7.8 23.1 13.1 10.5 10.8 10.0 12.3 5.0 17.6 15.1 16.4 13.4 15.6 23.2 27.6 15.8 25.2 6.7 9.6 21.1 15.7 13.8 24.6 18.1 1.5 15.0 14.1 25.1 26.8 13.0 5.8 31.4 17.7 20.9 13.8 2.2 28.6 10.3 7.3 7.0 5.2 8.7 29.1 13.0 0.0 2.8 3.4 5.2 3.0 7.7 1.9 5.0 5.3 4.0 2.6 4.8 3.6 0.6 3.2 2.9 2.4 5.2 4.0 16.6 16.7 18.4 21.0 25.5 16.0 16.0 16.2 16.5 14.2 16.9 15.5 5.9 9.6 16.0 18.6 7.1 4.5 4.9 7.2 5.7 13.2 7.8 8.6 9.7 10.0 8.7 12.9 8.4 20.8 6.5 12.9 1.9 10.7 64.5 9.6 7.3 8.0 7.8 1.3 21.5 6.7 12.9 9.0 9.2 9.9 2.5 15.1 11.0 10.1 10.8 21.9 25.9 8.4 10.2 5.4 5.9 33.0 8.7 5.6 5.4 15.9 7.5 12.3 5.2 18.6 11.1 8.1 6.0 10.1 6.8 4.9 14.2 7.5 6.8 16.6 6.6 7.5 7.2 71.6 9.6 5.7 3.0 17.5 9.0 6.2 9.1 2.6 POMT2 LGMD2N ENSG00000009830 "Protein O-mannosyltransferase 2" Q9UKY4 14 77274956-77320883 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Congenital muscular dystrophy, Dystroglycanopathy, Limb-girdle muscular dystrophy, Lissencephaly" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 37.5" "Cell type enhanced" "Detected in many" "Astrocytes: 27.1;Oligodendrocytes: 30.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003663 Uncertain Approved Nucleoplasm,Nucleoli,Cytosol NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 43: Testis - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 52: Non-specific - Transcription" Nucleoplasm "Nucleoli, Cytosol" "HPA003663: AB_1079655" "unprognostic (2.15e-1)" "unprognostic (1.07e-2)" "unprognostic (7.92e-2)" "unprognostic (3.37e-2)" "unprognostic (1.48e-1)" "unprognostic (1.31e-1)" "prognostic unfavorable (2.40e-4)" "unprognostic (7.10e-3)" "unprognostic (1.17e-1)" "unprognostic (1.68e-1)" "unprognostic (6.89e-3)" "unprognostic (1.94e-3)" "unprognostic (8.50e-3)" "unprognostic (1.37e-1)" "unprognostic (2.44e-1)" "unprognostic (6.75e-3)" "unprognostic (3.46e-2)" 5.8 12.4 13.2 4.1 14.9 2.5 5.7 13.5 13.4 8.0 12.5 6.7 2.6 6.7 9.8 5.5 5.8 4.0 7.9 12.7 13.1 10.8 9.3 5.6 1.8 14.6 14.6 6.1 8.8 8.6 12.6 7.0 13.4 7.8 3.3 5.6 6.3 6.9 19.1 4.7 4.9 4.6 13.7 5.6 5.9 37.5 14.4 2.9 10.9 8.4 1.9 7.9 5.3 15.4 15.6 19.4 18.6 21.1 13.0 10.3 14.8 13.4 10.8 19.3 16.6 9.6 13.6 4.6 10.6 12.6 27.1 17.1 8.8 13.3 13.5 6.9 12.1 2.8 8.9 7.9 15.8 3.2 8.9 10.5 13.9 18.3 17.8 13.6 11.5 4.5 7.4 10.5 13.0 30.7 5.4 15.0 5.3 21.4 16.2 5.3 18.0 4.1 20.4 11.3 15.6 15.2 8.7 14.6 11.3 12.0 15.1 6.5 9.6 14.6 22.8 17.1 12.0 6.8 14.5 2.1 7.4 4.8 13.2 0.0 0.0 0.0 0.4 0.4 0.0 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.2 0.4 0.0 0.1 13.2 14.9 13.5 13.4 12.7 13.1 14.6 14.6 13.4 13.7 14.4 15.4 3.2 6.4 2.8 27.1 2.0 3.1 2.7 3.4 2.8 7.5 7.2 7.6 4.3 4.3 1.6 1.8 16.7 6.0 1.2 6.5 0.0 7.6 14.3 5.8 6.7 3.1 18.0 0.0 12.9 7.5 10.2 6.1 4.1 7.0 2.5 6.4 2.5 5.7 5.5 8.4 14.5 3.2 2.0 2.2 2.6 17.2 1.8 2.4 1.8 9.4 2.3 5.9 0.0 20.1 30.5 5.5 3.2 4.1 2.1 5.2 2.5 3.6 5.1 15.1 0.0 6.2 5.0 11.3 8.2 5.2 1.8 5.7 1.2 13.9 3.6 1.9 PORCN "DHOF, MG61, por, PORC, PPN" ENSG00000102312 "Porcupine O-acyltransferase" Q9H237 X 48508962-48520814 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Wnt signaling pathway" "Acyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 37.3" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 68.5;Club cells: 44.2;Pancreatic endocrine cells: 36.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HBEC3-KT: 176.9;LHCN-M2: 60.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA049215, HPA058413" Enhanced Approved Vesicles NA NA "Cluster 38: Basophils - Unknown function" "Cluster 17: Adrenal gland - Steroid metabolism" "Cluster 30: Epithelial cell lines - Translation" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Vesicles "HPA049215: , HPA058413: AB_2683711" "unprognostic (1.11e-1)" "unprognostic (1.01e-1)" "unprognostic (1.93e-1)" "unprognostic (4.01e-2)" "unprognostic (2.19e-1)" "unprognostic (1.98e-1)" "unprognostic (1.26e-3)" "unprognostic (1.11e-1)" "unprognostic (1.07e-1)" "unprognostic (2.09e-2)" "unprognostic (2.65e-1)" "unprognostic (1.18e-1)" "unprognostic (1.03e-1)" "unprognostic (1.69e-1)" "unprognostic (1.37e-1)" "unprognostic (1.37e-1)" "unprognostic (2.35e-1)" 5.2 37.3 8.7 3.3 8.3 2.9 4.7 7.0 10.6 9.1 4.5 6.3 2.3 7.1 2.1 10.8 5.8 4.6 11.5 11.2 7.0 3.7 1.5 4.6 3.6 7.1 6.6 4.3 3.5 9.8 4.7 2.4 7.2 4.5 1.6 7.4 4.9 11.6 7.6 5.9 3.7 4.6 6.2 4.5 5.2 5.1 7.7 2.3 6.3 3.5 3.3 6.2 7.1 7.8 13.1 15.6 3.8 26.6 15.9 9.4 1.6 3.7 7.7 5.8 3.9 1.8 19.7 1.1 15.9 8.3 6.5 17.3 5.5 176.9 1.8 8.3 1.8 2.2 9.0 3.8 23.4 2.0 22.5 12.2 20.6 16.8 36.0 13.5 5.3 6.4 1.0 12.1 60.8 3.7 2.0 2.8 4.9 4.0 10.4 4.0 4.6 20.5 9.8 5.1 4.2 6.5 30.8 5.9 5.9 2.5 6.7 1.0 3.3 15.0 7.8 36.4 6.8 10.4 6.3 1.5 43.0 4.9 8.7 16.9 5.5 6.8 10.8 4.9 8.5 3.2 7.1 9.0 6.8 3.5 4.7 7.1 1.1 8.4 4.3 3.6 4.9 4.7 8.7 8.3 7.0 10.6 11.2 7.0 7.1 6.6 7.2 6.2 7.7 7.8 5.4 6.4 2.8 5.2 3.8 4.0 5.3 68.5 8.0 15.4 2.9 4.6 3.4 4.3 44.2 16.5 18.8 0.3 7.3 0.8 1.9 6.9 0.2 13.4 3.5 5.7 6.0 1.3 7.8 9.9 1.3 5.0 3.6 17.8 5.7 3.9 5.0 0.7 3.5 8.4 7.6 2.9 12.2 2.7 4.5 0.1 5.6 2.5 3.6 2.8 3.1 10.1 10.3 6.0 2.8 36.4 1.8 4.1 6.3 2.5 0.2 0.7 8.7 15.5 6.6 4.0 4.8 2.9 4.9 4.2 3.8 8.2 6.9 7.5 1.5 6.6 PPAT "GPAT, PRAT" ENSG00000128059 "Phosphoribosyl pyrophosphate amidotransferase" Q06203 4 56393362-56435615 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Purine biosynthesis" "Allosteric enzyme, Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Granulosa cells: 66.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036091, HPA036092" Approved Approved "Midbody ring" Yes No 11000 "Cluster 27: Non-specific - Gene expression" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 40: Granulosa cells - Unknown function" "Midbody ring" "HPA036091: AB_2674936, HPA036092: AB_10603132" "unprognostic (5.11e-2)" "unprognostic (5.13e-2)" "unprognostic (1.39e-2)" "prognostic unfavorable (5.15e-5)" "unprognostic (1.38e-1)" "unprognostic (4.37e-3)" "prognostic unfavorable (1.14e-8)" "unprognostic (6.74e-3)" "unprognostic (2.95e-2)" "unprognostic (3.79e-2)" "unprognostic (2.88e-3)" "unprognostic (1.51e-1)" "prognostic unfavorable (8.34e-4)" "unprognostic (1.41e-1)" "unprognostic (3.01e-1)" "prognostic unfavorable (1.95e-4)" "unprognostic (1.09e-1)" 2.8 6.1 3.8 5.4 4.0 5.6 7.1 3.7 4.7 4.3 3.6 3.9 4.0 4.6 3.4 4.5 4.4 3.0 2.3 4.1 4.0 6.0 6.1 2.2 8.4 3.4 4.0 7.4 5.9 3.9 2.5 6.7 4.3 3.9 4.8 4.4 5.6 3.1 2.9 4.3 3.2 3.6 3.7 4.3 3.5 8.6 4.1 8.3 5.9 2.9 8.0 6.7 2.6 4.2 23.1 19.0 38.0 18.7 12.2 15.7 31.0 25.2 11.1 20.4 21.6 38.1 27.5 80.6 33.4 11.9 19.0 16.8 74.0 25.4 40.7 21.1 32.8 32.6 22.6 42.2 18.4 65.0 19.5 13.6 19.4 29.0 32.4 12.6 21.8 32.5 83.5 43.3 23.2 20.9 80.6 49.1 50.6 52.0 22.4 67.2 24.9 56.9 34.2 16.2 64.0 31.2 20.1 36.3 23.0 35.4 24.5 13.8 15.3 21.2 36.6 21.4 45.0 32.2 34.5 82.9 23.6 40.7 20.1 4.7 1.8 0.9 3.8 2.7 5.9 7.4 5.1 5.2 2.5 6.1 7.7 7.1 0.5 10.2 3.9 3.2 4.3 3.5 3.8 4.0 3.7 4.7 4.1 4.0 3.4 4.0 4.3 3.7 4.1 4.2 4.8 0.0 5.5 16.6 10.7 31.0 16.0 5.6 28.5 8.4 10.1 9.7 3.8 4.3 8.0 3.7 2.1 29.7 10.3 1.5 9.8 3.7 2.6 5.5 14.1 7.8 4.2 14.9 22.9 2.7 25.2 9.4 4.1 6.9 7.0 66.2 5.3 7.1 7.9 38.7 15.8 4.3 4.1 1.6 6.0 2.6 7.8 5.2 8.8 5.6 3.1 6.4 2.1 5.5 9.1 3.3 2.7 5.7 15.3 15.0 0.8 12.7 6.2 4.7 0.0 9.3 10.8 16.4 27.5 18.3 31.8 7.7 10.7 21.9 9.0 8.7 PPIL2 "CYC4, Cyp-60, UBOX7" ENSG00000100023 "Peptidylprolyl isomerase like 2" Q13356 22 21666000-21700015 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Late spermatids: 90.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in all" 4 "K-562: 190.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035344, HPA055637" Supported Enhanced Nucleoplasm NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 8: Non-specific - Mitochondria" "Cluster 1: K-562 - Erythropoiesis" "Cluster 34: Spermatids - Unknown function" Nucleoplasm "HPA035344: AB_10672863, HPA055637: AB_2682869" "unprognostic (1.97e-3)" "unprognostic (3.61e-2)" "unprognostic (2.70e-2)" "unprognostic (4.31e-2)" "unprognostic (2.27e-1)" "unprognostic (2.90e-3)" "unprognostic (5.16e-3)" "unprognostic (3.77e-2)" "unprognostic (9.46e-2)" "unprognostic (1.54e-1)" "unprognostic (2.33e-2)" "unprognostic (1.89e-2)" "unprognostic (2.45e-3)" "unprognostic (5.46e-2)" "unprognostic (5.39e-2)" "unprognostic (5.39e-2)" "unprognostic (1.54e-3)" 8.9 14.2 4.7 12.8 5.7 6.3 9.5 4.0 7.0 11.6 2.1 12.1 8.1 12.0 9.3 16.4 10.7 9.5 13.9 5.8 4.8 12.6 15.0 10.1 16.4 3.5 2.9 10.7 19.2 16.4 14.3 9.1 3.9 12.4 10.6 9.0 14.7 9.5 18.8 12.3 13.3 9.9 3.6 14.0 13.9 10.1 3.1 15.8 18.8 13.0 16.4 11.7 12.1 4.8 20.4 17.1 18.1 20.1 19.2 17.6 15.8 19.3 17.9 28.0 24.5 21.3 10.3 34.0 12.7 27.2 13.9 22.9 28.6 23.6 16.2 19.2 28.2 26.7 14.2 32.4 14.7 42.5 21.5 17.4 21.2 19.4 14.0 15.1 25.1 18.5 190.3 17.9 19.6 28.6 20.5 13.7 20.2 35.7 14.9 23.7 31.1 5.7 14.2 14.1 30.8 18.4 21.2 32.7 9.7 11.3 27.1 20.3 27.5 15.8 25.1 17.5 12.7 19.2 17.5 24.7 21.6 22.6 24.9 1.5 9.7 5.1 9.6 15.3 12.2 7.2 11.5 12.6 13.7 8.3 10.5 9.4 2.3 14.1 22.6 11.9 15.6 12.1 4.7 5.7 4.0 7.0 5.8 4.8 3.5 2.9 3.9 3.6 3.1 4.8 9.8 9.6 29.5 15.0 21.5 3.2 7.9 10.9 10.8 26.3 13.4 10.2 5.7 27.1 16.6 14.7 33.3 15.8 39.4 23.9 13.7 12.8 66.8 15.4 14.8 8.0 11.4 17.7 19.9 16.7 13.3 10.3 39.3 19.5 17.1 16.6 10.4 18.9 15.3 18.5 24.2 20.6 14.2 21.0 5.3 90.9 12.2 15.5 1.8 8.4 16.6 11.5 52.5 12.5 17.4 18.5 17.4 13.5 23.8 10.9 14.2 9.1 11.9 31.4 0.0 11.2 9.4 23.6 17.3 12.3 5.7 22.2 24.5 14.8 20.8 12.6 PPIP5K1 "HISPPD2A, IPS1, KIAA0377, VIP1" ENSG00000168781 "Diphosphoinositol pentakisphosphate kinase 1" Q6PFW1 15 43533462-43590253 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 41.7;Excitatory neurons: 46.6;Inhibitory neurons: 37.6;Rod photoreceptor cells: 44.2" "Low cancer specificity" "Detected in all" "Region enhanced" "Detected in many" "cerebellum: 45.4" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039380 Approved Supported "Plasma membrane,Cytosol" NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 21: Non-specific - Transcription" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 9: Photoreceptor cells - Phototransduction" "Plasma membrane, Cytosol" "HPA039380: AB_10673528" "unprognostic (8.72e-2)" "unprognostic (6.49e-2)" "unprognostic (1.90e-2)" "unprognostic (1.12e-1)" "unprognostic (2.38e-1)" "unprognostic (2.78e-1)" "unprognostic (8.18e-2)" "unprognostic (5.78e-2)" "unprognostic (2.59e-3)" "prognostic unfavorable (8.57e-4)" "unprognostic (6.67e-2)" "unprognostic (2.85e-3)" "prognostic favorable (7.14e-8)" "unprognostic (2.67e-2)" "unprognostic (3.35e-2)" "unprognostic (5.92e-3)" "unprognostic (7.95e-3)" 6.6 14.8 5.7 7.3 9.8 5.9 10.3 45.4 21.0 8.3 1.1 17.6 24.7 7.4 15.1 11.6 9.4 8.3 7.5 8.0 1.8 8.5 5.6 5.8 7.8 6.0 0.6 9.2 9.4 33.7 21.6 4.5 8.8 10.0 17.6 53.7 13.8 8.3 20.0 20.0 24.3 7.7 0.0 8.6 15.5 15.5 2.8 5.4 14.3 21.2 10.0 9.0 9.9 9.2 14.5 9.3 8.1 15.0 4.8 3.0 13.8 7.1 9.0 10.0 14.6 11.0 13.5 13.5 10.5 9.8 14.9 38.6 15.8 30.6 10.1 13.3 12.5 20.3 29.9 5.9 11.0 23.4 20.2 5.4 26.6 12.2 18.6 13.5 10.7 31.0 15.0 19.4 7.4 11.3 7.8 13.2 3.9 27.0 10.0 16.7 8.2 6.8 10.7 25.9 24.1 7.6 18.3 17.2 6.7 11.4 31.7 19.4 4.7 8.7 10.2 11.1 17.4 4.3 5.7 16.4 16.3 26.5 8.5 2.4 0.5 0.0 1.0 1.1 1.3 2.0 1.2 1.3 1.2 1.2 0.9 0.9 0.3 1.5 0.8 0.9 0.3 1.3 5.7 9.8 45.4 21.0 8.0 1.8 6.0 0.6 8.8 0.0 2.8 9.2 2.3 0.0 2.2 11.4 5.2 4.0 1.5 3.2 7.4 16.5 3.2 3.3 5.4 2.8 3.4 7.3 41.7 3.3 2.9 9.2 0.0 2.1 2.7 2.1 1.4 2.9 2.4 5.5 46.6 1.5 0.9 1.8 20.9 2.8 0.0 9.5 3.3 1.8 1.9 10.1 37.6 5.9 0.0 2.8 1.8 2.4 1.8 2.1 0.0 15.0 1.8 3.9 0.0 11.6 11.0 1.9 5.2 7.2 3.1 1.2 12.2 1.5 2.3 44.2 6.6 2.3 3.2 8.1 3.3 7.3 3.3 2.2 3.1 3.5 8.2 3.2 PPIP5K2 "CFAP160, DFNB100, HISPPD1, KIAA0433, VIP2" ENSG00000145725 "Diphosphoinositol pentakisphosphate kinase 2" O43314 5 103120149-103212799 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Hearing "Kinase, Transferase" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Inhibitory neurons: 160.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037895, HPA038442" Approved Approved Vesicles NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 34: Non-specific - Transcription" "Cluster 32: U-937 - Innate immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Vesicles "HPA037895: AB_2675724, HPA038442: AB_10673173" "unprognostic (2.18e-1)" "unprognostic (1.04e-1)" "unprognostic (2.36e-2)" "unprognostic (1.93e-1)" "unprognostic (8.83e-2)" "unprognostic (1.60e-3)" "unprognostic (1.13e-1)" "unprognostic (2.43e-1)" "unprognostic (1.60e-2)" "unprognostic (8.59e-3)" "unprognostic (1.39e-1)" "unprognostic (2.12e-1)" "unprognostic (4.32e-2)" "unprognostic (1.29e-1)" "unprognostic (4.06e-1)" "prognostic unfavorable (1.12e-4)" "unprognostic (8.80e-2)" 15.7 19.1 6.8 22.0 7.9 51.6 25.1 18.9 13.9 22.2 5.8 28.1 18.3 20.6 21.2 17.1 14.5 20.4 19.5 6.7 8.9 20.3 29.2 16.2 25.5 15.4 11.9 26.1 26.7 23.0 18.1 16.7 15.1 16.3 25.5 19.2 17.1 15.4 4.2 17.2 16.5 18.4 6.1 23.9 22.5 15.1 7.3 27.9 23.3 7.7 24.5 17.8 13.9 10.7 27.4 25.3 50.8 65.2 40.8 53.4 47.8 63.5 39.3 34.2 47.6 20.9 48.3 67.6 56.2 60.9 52.7 16.5 43.9 33.2 57.5 53.7 23.5 84.7 44.3 33.4 29.0 72.1 70.4 34.5 23.4 52.0 46.1 31.2 40.0 42.5 84.9 57.0 53.1 21.3 60.9 44.6 55.4 12.7 64.4 58.6 46.7 89.3 36.8 31.5 29.6 40.1 43.5 39.9 40.7 34.0 33.5 48.9 42.7 55.8 25.7 56.0 45.1 38.1 87.3 91.3 31.5 116.0 51.2 41.7 21.5 39.6 13.0 22.9 15.8 19.5 12.6 14.2 25.6 16.1 16.1 17.0 19.7 17.8 32.4 15.5 12.3 11.1 6.8 7.9 18.9 13.9 6.7 8.9 15.4 11.9 15.1 6.1 7.3 10.7 35.8 48.1 23.1 49.3 39.3 13.6 12.8 13.7 31.9 38.5 26.1 26.4 48.9 18.6 29.6 16.5 45.9 12.7 35.7 29.7 5.9 11.6 5.6 25.4 44.7 28.7 16.3 70.7 88.4 17.0 19.2 33.0 33.6 30.6 43.6 49.2 14.6 20.6 30.6 16.8 160.3 24.2 16.2 39.5 22.4 6.7 29.5 43.3 12.4 49.6 47.5 14.5 27.8 62.8 67.0 16.9 19.1 23.7 56.6 12.1 13.3 22.6 25.1 25.2 6.6 30.3 28.1 39.7 21.6 31.6 15.8 26.0 31.6 38.7 30.1 12.6 PPP1R11 "CFAP255, HCG-V, HCGV, TCTE5, Tctex5" ENSG00000204619 "Protein phosphatase 1 regulatory inhibitor subunit 11" O60927 6 30066709-30070333 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Protein phosphatase inhibitor, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "Late spermatids: 696.0" "Low cancer specificity" "Detected in all" "Region enriched" "Detected in some" 8 "cerebral cortex: 8.8" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "A-431: 51.5;AN3-CA: 65.6;fHDF/TERT166: 48.6;GAMG: 47.4;HBEC3-KT: 53.6;JURKAT: 76.7;RPTEC TERT1: 47.4;U-266/84: 64.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA043266, HPA060174" Approved Approved Vesicles NA NA 43000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 72: Non-specific - Transcription" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 10: Non-specific - Unknown function" Vesicles "HPA043266: AB_2678400, HPA060174: AB_2684216" "unprognostic (2.00e-2)" "unprognostic (1.10e-1)" "unprognostic (8.88e-2)" "unprognostic (4.24e-2)" "unprognostic (3.45e-1)" "unprognostic (1.05e-1)" "unprognostic (1.77e-2)" "unprognostic (1.18e-1)" "unprognostic (2.81e-1)" "unprognostic (1.74e-3)" "unprognostic (3.33e-2)" "unprognostic (2.68e-1)" "unprognostic (8.36e-3)" "unprognostic (1.74e-1)" "unprognostic (3.31e-1)" "unprognostic (2.21e-1)" "unprognostic (4.69e-3)" 44.5 41.1 0.7 0.0 0.7 1.9 41.4 0.6 8.8 44.4 0.6 55.5 11.6 49.6 33.1 52.1 37.3 11.8 51.0 0.7 0.7 62.3 47.5 43.7 5.4 0.9 0.7 41.8 45.1 2.2 29.2 5.8 0.8 46.3 0.7 7.9 42.8 0.0 50.4 42.9 50.7 0.0 0.6 39.8 59.5 41.5 0.7 9.7 42.3 0.0 11.8 51.6 42.7 1.1 51.5 0.0 0.0 65.6 29.4 26.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 48.6 47.4 0.0 0.0 53.6 0.0 1.0 34.5 42.6 0.0 0.0 0.0 3.0 3.9 0.0 0.0 0.0 0.7 0.0 0.0 76.7 0.5 2.7 0.0 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.0 1.4 47.4 29.0 0.0 0.0 0.7 35.5 4.8 26.8 0.0 0.0 0.0 0.0 0.3 4.1 1.5 30.7 64.9 26.7 0.7 0.0 0.0 11.5 4.1 12.4 4.7 9.3 4.5 6.8 5.3 6.5 2.2 7.2 4.9 7.0 2.8 3.9 7.9 3.2 8.4 6.8 0.7 0.7 0.6 8.8 0.7 0.7 0.9 0.7 0.8 0.6 0.7 1.1 38.2 19.2 20.2 2.6 57.8 52.8 80.0 77.2 29.0 29.3 47.7 32.8 18.8 52.9 49.7 40.5 6.2 56.0 39.2 111.5 95.9 142.2 242.1 19.8 24.2 44.3 53.7 32.4 10.1 136.3 119.9 27.0 53.5 31.8 78.6 21.4 45.7 28.0 65.7 13.5 9.0 83.8 77.3 49.7 53.8 696.0 32.3 43.5 62.2 3.7 75.4 58.4 92.7 6.0 7.6 136.5 114.1 40.3 42.2 66.6 139.6 93.3 38.7 33.1 39.5 27.2 89.4 61.9 23.2 39.0 66.5 75.2 52.4 16.5 51.8 94.9 PRDM16 "KIAA1675, KMT8F, MEL1, MGC166915, PFM13" ENSG00000142611 "PR/SET domain 16" Q9HAZ2 1 3069168-3438621 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Differentiation, Transcription, Transcription regulation" "Activator, DNA-binding, Methyltransferase, Repressor, Transferase" "Cancer-related genes, Cardiomyopathy, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 16.2" "Cell type enriched" "Detected in many" 4 "Astrocytes: 173.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in single" 16 "NK-cell: 2.4" "Lineage enriched" "Detected in single" 16 "NK-cells: 2.4" "Cell line enhanced" "Detected in some" "HEK 293: 1.8;HHSteC: 2.0;hTERT-RPE1: 6.7;MCF7: 1.6;OE19: 3.5" "Region enriched" "Detected in many" 5 "basal ganglia: 15.7" "Low region specificity" "Detected in many" "HPA050343, HPA060467" Supported Nucleoplasm NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 21: OE19 - Mitochondria" "Cluster 64: Astrocytes - Nervous system maintenance" Nucleoplasm "HPA050343: AB_2681099, HPA060467: AB_2684287" "unprognostic (2.44e-1)" "unprognostic (1.44e-1)" "unprognostic (5.31e-4)" "unprognostic (1.27e-1)" "unprognostic (1.14e-1)" "unprognostic (3.95e-2)" "unprognostic (9.15e-3)" "unprognostic (5.68e-4)" "unprognostic (2.58e-1)" "unprognostic (2.07e-2)" "unprognostic (5.21e-2)" "unprognostic (1.71e-1)" "unprognostic (7.80e-6)" "unprognostic (2.14e-1)" "unprognostic (1.73e-1)" "prognostic unfavorable (4.70e-5)" "unprognostic (4.06e-2)" 1.6 0.2 3.7 0.5 4.8 0.0 1.1 0.1 4.1 1.3 16.2 1.1 7.4 1.0 2.1 0.3 1.4 1.1 5.4 2.8 0.6 6.8 0.2 2.5 0.5 0.5 1.7 1.5 5.8 0.9 0.6 0.1 0.9 0.7 0.2 0.0 0.4 2.2 0.4 0.5 2.6 0.2 0.0 2.1 9.3 0.7 4.1 0.1 8.0 0.6 0.3 0.9 1.1 1.5 0.0 0.0 0.5 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.2 1.4 0.3 0.0 0.2 0.0 0.2 0.0 1.3 0.0 0.0 0.1 1.8 0.0 0.0 0.3 2.0 0.0 0.7 0.0 0.0 0.0 0.0 6.7 0.0 0.1 0.0 0.0 0.0 1.6 0.1 0.0 0.1 3.5 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.4 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 2.4 0.0 0.0 0.0 0.0 3.7 4.8 0.1 4.1 2.8 0.6 0.5 1.7 0.9 0.0 4.1 1.5 4.5 35.3 10.5 173.7 0.1 0.6 0.3 2.1 0.6 0.1 0.2 0.3 5.2 22.8 6.3 7.3 0.0 0.0 0.1 0.2 5.9 10.0 0.3 0.2 0.0 2.1 5.4 0.8 1.2 4.9 4.2 0.6 30.5 0.4 0.0 0.3 0.0 0.0 0.0 1.7 1.0 0.9 0.0 0.0 0.4 0.2 1.5 0.1 0.0 14.0 0.0 1.4 0.0 6.6 1.8 7.1 0.8 1.9 0.1 0.8 0.5 0.2 1.9 0.3 0.0 3.3 9.0 0.3 1.8 0.2 0.0 0.0 0.4 0.0 1.5 0.2 PRDM2 "HUMHOXY1, KMT8, KMT8A, MTB-ZF, RIZ, RIZ1, RIZ2" ENSG00000116731 "PR/SET domain 2" Q13029 1 13700198-13825079 "Enzymes, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Activator, DNA-binding, Methyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "B-cells: 182.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005809 Approved Approved "Nucleoplasm,Golgi apparatus" NA NA "Cluster 37: B-cells - Transcription" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 57: B-cells - Immune response" "Nucleoplasm, Golgi apparatus" "HPA005809: AB_1079673" "unprognostic (2.22e-1)" "unprognostic (3.28e-1)" "unprognostic (5.34e-2)" "unprognostic (1.28e-2)" "unprognostic (6.70e-2)" "unprognostic (2.72e-3)" "unprognostic (1.94e-2)" "unprognostic (1.12e-2)" "unprognostic (3.20e-2)" "unprognostic (2.53e-2)" "unprognostic (2.30e-1)" "unprognostic (1.35e-1)" "unprognostic (9.63e-3)" "unprognostic (3.81e-1)" "unprognostic (2.45e-1)" "unprognostic (1.85e-1)" "unprognostic (5.85e-3)" 21.7 15.2 19.4 19.3 21.2 79.4 21.9 27.5 38.7 27.8 7.6 27.1 13.0 24.2 16.4 21.9 20.9 17.0 19.9 21.5 18.2 14.2 13.1 21.4 27.3 18.5 16.6 34.3 14.9 14.7 16.3 16.7 18.7 24.3 13.8 18.1 21.2 17.6 43.8 27.2 23.6 15.0 12.9 20.2 19.2 18.7 16.9 22.6 24.3 30.0 25.0 27.0 26.8 34.7 15.3 8.5 30.3 11.8 23.5 18.0 14.6 19.5 11.8 13.0 14.5 13.5 16.9 46.4 16.7 18.9 11.0 18.5 22.8 11.4 14.4 28.9 16.3 31.2 10.6 6.4 12.9 10.5 25.8 19.1 19.7 13.8 11.4 12.4 13.0 18.0 28.2 52.0 16.5 7.7 16.9 16.6 9.0 12.1 11.4 23.3 16.4 13.9 7.4 17.0 26.3 17.0 15.7 9.8 21.4 18.0 13.9 16.8 23.2 16.7 18.1 15.3 10.9 75.8 55.4 65.5 14.8 24.1 21.9 4.7 4.9 7.5 5.5 3.2 3.5 18.5 4.4 5.2 3.0 13.4 4.9 4.4 9.9 6.2 6.0 5.6 4.4 2.8 19.4 21.2 27.5 38.7 21.5 18.2 18.5 16.6 18.7 12.9 16.9 34.7 41.3 38.5 39.7 34.3 182.9 62.1 54.8 17.1 61.5 49.5 43.8 33.8 41.3 27.1 33.0 23.9 45.9 25.6 77.7 26.9 17.6 17.3 21.7 84.5 62.5 35.1 37.8 21.7 114.5 13.8 16.2 47.6 25.5 121.2 40.5 50.0 26.0 18.8 16.6 70.7 97.0 24.1 14.2 45.6 39.9 15.6 44.1 42.1 30.2 75.9 41.5 21.2 59.8 70.4 122.5 15.5 25.7 45.1 71.7 54.5 34.2 9.0 43.8 39.7 26.3 86.3 34.4 52.7 49.4 65.4 52.1 18.3 74.4 25.8 19.6 64.5 PRDM6 "KMT8C, PRISM" ENSG00000061455 "PR/SET domain 6" Q9NQX0 5 123089241-123194266 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Transcription, Transcription regulation" "Chromatin regulator, Methyltransferase, Repressor, Transferase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "intestine: 4.9;urinary bladder: 9.0" "Cell type enhanced" "Detected in some" "Astrocytes: 15.0;Endometrial stromal cells: 6.5;Excitatory neurons: 7.9;Fibroblasts: 10.7;Late spermatids: 7.1;Oligodendrocytes: 11.0" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 3.6;HEK 293: 5.2;HEL: 1.1" "Not detected" "Not detected" "Region enhanced" "Detected in single" "spinal cord: 2.3" HPA030324 Uncertain Approved Nucleoplasm NA NA "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 28: BEWO - Transcription regulation" "Cluster 33: Fibroblasts - ECM organization" Nucleoplasm "HPA030324: AB_10670032" "unprognostic (2.33e-1)" "unprognostic (1.39e-1)" "unprognostic (2.18e-1)" "unprognostic (2.32e-3)" "unprognostic (3.12e-1)" "unprognostic (5.44e-2)" "unprognostic (2.22e-1)" "unprognostic (1.54e-2)" "unprognostic (4.66e-2)" "unprognostic (7.66e-3)" "unprognostic (1.23e-1)" "unprognostic (1.92e-2)" "unprognostic (1.02e-7)" "unprognostic (9.30e-4)" "unprognostic (1.10e-1)" "unprognostic (3.43e-4)" "unprognostic (1.27e-1)" 0.7 0.1 0.2 0.3 0.2 0.0 0.6 0.2 0.3 0.9 0.6 4.9 0.2 0.7 0.1 0.6 0.4 3.3 0.5 0.1 0.2 0.3 0.1 2.9 0.0 0.3 0.4 1.9 0.3 0.1 0.3 4.2 0.4 1.3 1.0 0.2 0.1 0.1 0.1 0.2 0.6 0.7 0.3 0.0 0.6 0.3 0.2 0.0 0.8 0.2 0.2 9.0 0.6 0.3 0.0 0.0 0.0 0.3 0.3 0.4 3.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.2 0.0 0.0 0.7 0.0 0.0 0.1 5.2 1.1 0.5 0.0 1.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.6 0.2 0.0 0.8 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.2 0.3 0.1 0.2 0.3 0.4 0.4 0.3 0.2 0.3 0.5 0.0 0.0 15.0 0.0 1.9 0.1 0.0 0.0 1.0 0.6 0.3 1.4 0.0 0.0 0.0 2.1 0.3 0.0 0.0 0.0 0.1 3.3 0.6 6.5 0.5 0.0 0.0 7.9 0.2 0.3 10.7 0.0 0.5 0.0 2.4 0.0 0.5 0.8 0.0 6.4 0.1 0.0 0.8 3.5 7.1 2.1 0.4 3.6 4.7 0.8 0.2 0.0 3.0 11.0 0.1 0.0 1.2 0.1 0.2 0.0 0.8 0.2 1.0 0.0 0.7 2.2 2.3 4.4 0.2 1.3 0.4 0.4 6.1 0.0 0.1 PRDM9 "KMT8B, MSBP3, PFM6, ZNF899" ENSG00000164256 "PR/SET domain 9" Q9NQV7 5 23443586-23528093 "Enzymes, Predicted intracellular proteins, Transcription factors" "Meiosis, Transcription, Transcription regulation" "Activator, Chromatin regulator, DNA-binding, Methyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 4.5;epididymis: 1.6;testis: 4.0" "Cell type enriched" "Detected in some" 4 "Spermatocytes: 44.4" "Not detected" "Not detected" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Cell line enriched" "Detected in single" 12 "U-266/70: 6.9" HPA059555 Uncertain NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 29: U-266 - Adaptive immune response" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" "HPA059555: AB_2684061" "unprognostic (1.23e-4)" "unprognostic (8.64e-2)" "unprognostic (2.18e-2)" "unprognostic (8.34e-2)" "unprognostic (4.11e-1)" 0.0 0.0 0.4 0.0 1.6 0.9 0.0 0.4 1.0 0.0 1.2 0.0 0.0 0.0 1.6 0.0 0.1 0.0 0.0 0.4 1.4 0.1 0.0 0.0 0.1 1.6 1.0 0.1 0.4 0.0 0.0 0.0 2.0 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.4 0.1 0.0 4.0 1.3 0.0 0.1 0.0 0.0 0.0 0.0 4.5 0.0 0.2 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.1 0.1 0.5 0.0 0.0 6.9 0.1 0.0 0.0 0.1 0.0 1.0 0.2 0.0 0.2 0.1 0.2 0.3 0.2 0.1 0.1 0.4 0.2 0.2 1.2 0.6 0.1 0.1 0.1 0.0 0.4 1.6 0.4 1.0 0.4 1.4 1.6 1.0 2.0 0.4 1.3 4.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.3 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 44.4 9.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PRDX6 "1-Cys, aiPLA2, AOP2, KIAA0106, MGC46173, NSGPx, p29, PRX" ENSG00000117592 "Peroxiredoxin 6" P30041 1 173477330-173488815 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Lipid degradation, Lipid metabolism" "Antioxidant, Hydrolase, Multifunctional enzyme, Oxidoreductase, Peroxidase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal enterocytes: 1315.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006983, CAB008663" Supported Supported "Plasma membrane,Cytosol" NA NA 120000000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 39: Non-specific - Mitochondria" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 53: Intestinal epithelial cells - Unknown function" "Plasma membrane, Cytosol" "CAB008663: AB_1620994, HPA006983: AB_1079595" "unprognostic (9.92e-2)" "unprognostic (1.50e-1)" "unprognostic (3.67e-1)" "unprognostic (2.99e-3)" "unprognostic (1.96e-1)" "prognostic unfavorable (1.23e-5)" "unprognostic (5.71e-3)" "unprognostic (2.80e-2)" "unprognostic (5.27e-3)" "unprognostic (3.96e-3)" "unprognostic (3.19e-3)" "unprognostic (1.59e-1)" "prognostic unfavorable (9.51e-4)" "unprognostic (2.50e-1)" "unprognostic (7.12e-2)" "unprognostic (1.15e-1)" "unprognostic (4.73e-3)" 340.7 157.5 169.5 68.3 181.3 100.1 211.2 197.6 210.1 112.3 164.8 189.1 46.4 108.8 206.3 127.9 149.8 71.9 261.8 184.1 196.6 184.4 482.5 116.7 72.2 181.0 198.3 115.5 114.4 217.5 67.4 70.7 187.5 152.1 221.6 53.9 85.6 99.0 563.5 106.6 59.8 160.2 175.8 70.7 135.2 119.1 176.7 70.7 106.0 382.4 79.0 99.5 109.8 185.5 420.3 127.7 204.7 230.9 778.5 372.7 169.5 843.9 284.3 342.7 241.8 243.9 276.4 272.4 256.4 694.2 120.4 239.8 272.0 259.9 279.0 234.0 243.6 179.5 200.0 277.7 425.7 191.3 56.1 301.0 262.6 181.3 256.6 210.8 339.5 106.7 405.4 52.8 392.9 86.3 131.7 249.1 456.2 219.8 760.5 154.5 236.6 277.0 518.1 95.4 94.9 173.4 285.0 334.0 199.2 296.3 283.8 262.9 228.2 132.5 149.9 201.8 229.5 76.4 123.2 220.7 159.4 162.3 124.3 36.2 42.5 24.8 29.8 39.8 32.8 32.6 29.8 38.4 53.5 24.4 39.8 47.9 25.2 25.7 36.5 79.7 36.1 58.1 169.5 181.3 197.6 210.1 184.1 196.6 181.0 198.3 187.5 175.8 176.7 185.5 278.1 176.3 170.8 127.3 127.4 235.4 404.1 382.8 209.5 31.9 186.1 250.7 528.6 301.7 228.6 277.7 29.2 714.3 158.6 1315.9 860.8 178.6 237.5 206.9 226.8 191.8 142.1 449.5 13.8 202.3 939.1 307.0 111.6 200.0 348.6 216.6 214.2 1120.2 345.0 45.4 13.2 257.4 205.4 164.3 161.0 667.5 340.5 227.1 183.2 17.8 212.9 462.5 83.4 12.5 15.4 147.2 663.4 416.8 176.4 427.1 264.4 827.3 209.1 52.0 184.1 185.7 253.8 123.5 76.8 305.9 264.1 963.5 157.7 512.5 303.6 308.9 PRKAA1 AMPKa1 ENSG00000132356 "Protein kinase AMP-activated catalytic subunit alpha 1" Q13131 5 40759379-40798374 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "Autophagy, Biological rhythms, Cholesterol biosynthesis, Cholesterol metabolism, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism, Transcription, Transcription regulation, Wnt signaling pathway" "Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 4 "Early spermatids: 292.5;Late spermatids: 478.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005050, HPA035409, HPA064946" Supported Supported "Nuclear speckles,Cytosol" NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 34: Non-specific - Transcription" "Cluster 20: HeLa - Mitochondria" "Cluster 31: Spermatids - Spermatogenesis" "Nuclear speckles" Cytosol "CAB005050: AB_562037, HPA035409: AB_2674613, HPA064946: AB_2685390" "unprognostic (2.07e-1)" "unprognostic (1.41e-2)" "unprognostic (2.51e-2)" "unprognostic (3.57e-2)" "unprognostic (3.97e-1)" "unprognostic (1.05e-1)" "unprognostic (3.51e-2)" "unprognostic (7.53e-2)" "unprognostic (1.66e-2)" "unprognostic (2.88e-1)" "unprognostic (3.34e-3)" "unprognostic (2.63e-1)" "unprognostic (2.82e-2)" "unprognostic (1.35e-1)" "unprognostic (1.60e-1)" "unprognostic (1.27e-2)" "unprognostic (1.10e-2)" 33.3 21.0 7.9 27.2 9.6 52.6 30.2 10.3 11.0 26.7 12.3 30.0 35.4 26.3 18.6 20.6 21.0 33.5 20.2 6.9 11.3 32.0 49.9 27.4 29.2 11.8 9.9 19.1 23.1 32.0 9.2 21.2 12.2 31.9 34.7 19.0 27.4 24.7 16.9 23.1 30.9 26.4 10.2 27.8 33.7 41.1 10.0 21.8 32.3 19.9 23.9 28.8 17.8 10.3 28.4 28.9 22.8 30.2 55.0 57.0 21.6 47.3 48.1 34.7 30.8 27.6 35.9 16.6 21.4 48.8 45.3 22.4 21.3 43.1 64.9 49.2 19.2 33.1 66.1 22.1 45.3 31.9 33.5 52.8 20.6 46.5 47.5 38.4 52.1 21.0 15.9 46.7 52.4 13.6 29.7 24.9 9.9 28.9 34.6 24.5 48.7 24.6 53.3 47.5 19.6 19.7 83.0 54.3 28.8 12.3 28.4 26.0 56.0 62.1 33.5 36.2 39.2 18.5 15.4 19.6 38.9 67.9 33.9 17.0 6.5 12.8 8.9 7.9 11.5 8.2 8.4 8.6 6.4 7.9 10.1 9.0 15.4 10.9 9.3 1.9 11.6 6.5 7.9 9.6 10.3 11.0 6.9 11.3 11.8 9.9 12.2 10.2 10.0 10.3 47.3 41.7 26.5 19.2 34.1 24.1 24.7 40.5 15.4 20.3 36.1 17.9 18.3 42.9 43.4 47.8 35.5 13.8 45.8 44.1 7.9 27.9 292.5 19.7 35.8 42.4 21.1 25.4 24.5 44.9 13.7 36.2 36.7 20.7 18.3 17.8 37.1 83.4 20.0 15.2 30.3 28.8 42.7 25.3 28.5 478.5 30.4 24.1 35.6 24.4 40.9 15.4 44.3 30.7 43.8 36.0 32.8 25.9 23.4 33.4 33.7 35.4 42.9 27.9 0.0 22.7 43.1 82.8 17.6 19.9 32.7 18.6 44.0 19.2 36.9 35.0 PRKAA2 "AMPK, AMPKa2, PRKAA" ENSG00000162409 "Protein kinase AMP-activated catalytic subunit alpha 2" P54646 1 56645314-56715335 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted membrane proteins, Transporters" "Autophagy, Biological rhythms, Cholesterol biosynthesis, Cholesterol metabolism, Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis, Steroid metabolism, Sterol biosynthesis, Sterol metabolism, Transcription, Transcription regulation, Wnt signaling pathway" "Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 40.8;skeletal muscle: 38.7;tongue: 36.4" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 328.5;Excitatory neurons: 109.4;Inhibitory neurons: 119.0;Oligodendrocyte precursor cells: 84.9;Rod photoreceptor cells: 115.5" "Cancer enhanced" "Detected in many" "renal cancer: 5.8" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "RPTEC TERT1: 14.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044540 Approved Supported "Nuclear speckles,Golgi apparatus" NA NA "Cluster 38: Heart - Muscle contraction" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 54: Cardiomyocytes - Muscle contraction" "Nuclear speckles" "Golgi apparatus" "HPA044540: AB_2678977" "unprognostic (4.17e-3)" "unprognostic (1.62e-2)" "unprognostic (4.17e-1)" "prognostic unfavorable (4.80e-4)" "unprognostic (9.35e-2)" "unprognostic (1.92e-3)" "prognostic unfavorable (5.30e-4)" "unprognostic (7.30e-2)" "unprognostic (3.94e-1)" "unprognostic (1.82e-1)" "unprognostic (1.97e-1)" "unprognostic (8.64e-2)" "prognostic favorable (4.95e-5)" "unprognostic (1.30e-2)" "unprognostic (4.52e-2)" "unprognostic (1.57e-2)" "unprognostic (1.85e-1)" 1.4 1.4 2.0 0.5 3.5 0.0 3.3 3.0 3.5 1.4 4.1 5.0 0.5 1.8 1.1 4.7 2.7 1.9 40.8 3.9 2.1 13.6 0.7 1.4 0.1 0.9 1.3 1.5 1.8 8.3 1.3 0.5 0.9 3.8 1.4 13.5 4.3 2.6 38.7 0.7 1.3 3.1 0.3 1.3 2.2 1.1 1.3 0.4 3.3 36.4 0.1 1.8 1.3 1.5 0.0 3.8 2.1 0.0 0.7 0.5 2.3 1.9 1.5 2.5 4.3 3.9 4.9 0.0 0.6 0.6 7.5 0.1 8.0 0.0 7.1 0.0 8.8 0.0 7.0 5.5 0.0 0.0 0.1 0.6 0.0 3.5 0.3 5.8 0.8 2.0 0.0 0.0 1.1 0.1 0.0 0.0 5.6 0.0 5.5 0.0 0.0 0.0 14.1 1.3 2.0 5.5 6.0 0.1 0.0 6.0 3.3 0.0 0.0 1.5 2.3 2.8 6.6 0.0 0.0 0.0 4.5 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 3.5 3.0 3.5 3.9 2.1 0.9 1.3 0.9 0.3 1.3 1.5 1.1 9.6 4.8 30.7 2.0 0.9 8.0 6.7 2.2 42.0 19.4 9.5 328.5 24.3 14.3 49.7 50.1 1.0 0.2 6.1 54.8 9.5 3.9 14.4 2.9 10.3 14.4 0.0 109.4 4.8 0.4 15.3 5.1 17.4 2.5 11.7 9.7 8.1 0.1 26.9 119.0 6.3 8.2 0.0 1.6 4.8 6.8 1.4 5.4 18.7 0.0 18.6 0.0 84.9 20.4 6.2 3.0 29.3 0.0 21.2 0.2 82.4 10.7 115.5 6.6 24.5 17.2 7.2 3.7 17.7 0.4 0.4 1.2 5.3 6.1 13.4 PRKACA PKACa ENSG00000072062 "Protein kinase cAMP-activated catalytic subunit alpha" P17612 19 14091688-14118084 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Cushing syndrome, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 310.9" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 116.8;Theca cells: 100.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010361, HPA071185" Approved Approved "Cytokinetic bridge,Cytosol" Yes NA 170000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 39: Non-specific - Mitochondria" "Cluster 18: U-2197 - ECM organization" "Cluster 52: Non-specific - Transcription" Cytosol "Cytokinetic bridge" "CAB010361: AB_2268772, HPA071185: AB_2686356" "unprognostic (1.08e-1)" "prognostic favorable (6.28e-6)" "unprognostic (2.09e-2)" "prognostic unfavorable (6.26e-5)" "unprognostic (1.38e-2)" "unprognostic (2.95e-1)" "unprognostic (1.64e-1)" "unprognostic (9.36e-3)" "unprognostic (7.01e-2)" "unprognostic (3.41e-1)" "prognostic favorable (6.47e-4)" "unprognostic (2.86e-1)" "unprognostic (1.17e-1)" "unprognostic (4.68e-2)" "unprognostic (1.87e-1)" "unprognostic (3.66e-2)" "unprognostic (6.14e-3)" 62.7 126.5 46.6 27.6 47.6 18.9 53.9 39.9 64.2 53.2 29.5 59.0 20.9 56.9 28.5 41.8 53.7 14.2 204.8 49.2 53.3 35.4 78.4 46.1 15.9 56.8 54.5 94.1 34.0 21.6 71.2 17.3 55.3 41.2 13.0 25.2 42.3 20.8 310.9 42.3 36.3 21.8 40.7 71.6 40.2 57.2 50.3 18.2 39.6 122.1 13.4 50.6 44.2 46.6 37.5 16.3 40.3 74.4 36.2 30.8 9.9 30.5 23.6 32.7 27.5 21.6 15.0 13.8 26.2 49.2 22.9 25.4 26.7 26.6 32.3 23.1 17.7 27.7 20.6 24.4 36.8 21.9 33.5 33.8 18.1 30.0 11.1 26.6 29.7 19.0 29.1 47.3 36.7 48.1 46.3 31.9 21.5 38.7 45.0 38.0 47.8 36.7 41.7 13.5 36.5 24.2 34.2 31.3 23.8 18.1 37.2 26.5 37.7 71.7 20.3 100.7 39.6 31.9 24.9 23.6 49.6 28.0 32.7 0.1 1.5 0.2 0.8 2.7 0.3 0.8 0.3 0.5 1.1 0.5 0.5 0.7 3.2 0.4 2.5 0.6 0.3 0.6 46.6 47.6 39.9 64.2 49.2 53.3 56.8 54.5 55.3 40.7 50.3 46.6 39.5 6.4 3.4 9.4 7.0 8.8 6.8 6.4 2.2 42.2 19.2 19.0 116.8 22.8 4.7 14.7 27.1 6.9 9.0 24.6 7.9 12.4 32.4 11.7 22.9 26.7 17.5 2.5 16.9 19.1 5.7 22.6 8.6 12.9 0.0 15.9 26.4 39.7 34.5 3.3 21.6 11.8 2.0 49.4 50.8 15.7 49.0 37.1 14.2 9.4 37.8 26.1 9.2 10.1 10.7 15.6 11.6 51.9 3.3 6.4 20.7 11.8 7.0 23.9 19.7 23.3 23.5 26.4 6.9 10.1 11.2 8.1 10.0 100.6 14.4 6.6 PRKACB PKACb ENSG00000142875 "Protein kinase cAMP-activated catalytic subunit beta" P22694 1 84078062-84238498 "Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 334.4;Inhibitory neurons: 348.8;Oligodendrocyte precursor cells: 302.6;Oligodendrocytes: 499.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010363, HPA029754, HPA071185" Approved Approved "Cytokinetic bridge,Cytosol" Yes NA 130000 "Cluster 48: NK-cells - Unknown function" "Cluster 6: Brain - Smell perception" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol "Cytokinetic bridge" "CAB010363: AB_2170182, HPA029754: AB_10601491, HPA071185: AB_2686356" "unprognostic (9.38e-2)" "unprognostic (1.18e-1)" "unprognostic (6.37e-2)" "unprognostic (1.39e-1)" "unprognostic (1.58e-1)" "unprognostic (1.98e-1)" "prognostic unfavorable (9.49e-4)" "unprognostic (1.28e-1)" "unprognostic (3.28e-2)" "unprognostic (1.92e-1)" "unprognostic (2.31e-1)" "unprognostic (4.62e-2)" "prognostic favorable (1.89e-6)" "unprognostic (1.22e-1)" "unprognostic (3.28e-1)" "unprognostic (1.12e-2)" "unprognostic (2.48e-1)" 16.5 47.7 79.4 26.1 101.6 16.0 17.7 70.0 113.3 19.8 0.0 55.9 10.8 19.2 38.8 17.8 10.0 26.2 23.8 100.7 107.5 23.8 20.8 15.8 41.8 53.5 44.4 17.8 27.8 23.5 24.7 11.5 65.4 30.6 51.7 71.6 83.7 27.3 4.9 4.1 12.7 28.8 59.9 36.0 34.1 8.1 91.0 63.5 25.2 13.5 36.8 27.6 7.7 110.0 8.6 16.9 26.4 31.8 29.9 26.1 12.3 41.7 31.4 20.8 19.4 0.4 7.5 45.1 28.0 32.8 38.0 5.8 12.6 13.6 22.0 44.1 6.8 99.3 21.3 3.2 29.4 39.8 2.2 15.6 6.0 20.2 11.2 30.2 97.2 16.7 3.2 25.2 34.3 1.6 51.8 21.0 26.1 0.1 11.8 39.6 41.2 27.3 50.5 30.2 8.6 33.4 23.0 8.8 25.6 19.7 8.1 8.2 86.8 28.7 22.4 29.4 31.9 18.6 24.2 45.3 13.7 41.5 36.5 56.3 7.5 16.4 59.3 10.2 47.7 35.2 43.4 52.9 19.4 28.4 65.0 69.5 3.8 73.1 16.2 11.1 44.2 66.8 79.4 101.6 70.0 113.3 100.7 107.5 53.5 44.4 65.4 59.9 91.0 110.0 9.5 0.0 1.5 118.8 56.6 5.1 7.2 3.5 11.4 44.9 11.5 9.1 44.4 21.5 5.2 14.7 35.5 1.9 103.0 115.5 33.2 6.2 2.9 11.4 27.0 13.4 21.7 52.3 334.4 11.9 1.2 17.0 16.3 14.0 58.9 15.2 28.5 17.0 27.1 47.1 348.8 58.1 4.1 62.3 24.4 3.6 14.9 51.6 16.0 95.5 14.6 35.6 96.8 302.6 499.0 20.6 42.2 21.8 53.9 10.0 4.5 25.6 6.3 34.4 13.1 14.1 20.3 13.9 8.0 8.1 2.8 0.7 87.6 11.4 51.1 9.1 PRKACG PKACg ENSG00000165059 "Protein kinase cAMP-activated catalytic subunit gamma" P22612 9 69012504-69014113 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 152 "testis: 24.6" "Group enriched" "Detected in some" 27 "Early spermatids: 71.0;Late spermatids: 88.4;Spermatocytes: 41.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "CAB004530, HPA071185" Supported Uncertain "Cytokinetic bridge,Cytosol" Yes NA "Cluster 74: Testis - Spermatogenesis" "Cluster 66: Spermatocytes - Spermatogenesis" Cytosol "Cytokinetic bridge" "CAB004530: AB_628137, HPA071185: AB_2686356" "unprognostic (2.74e-1)" "unprognostic (3.61e-2)" "unprognostic (7.22e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 24.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 71.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 88.4 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 41.3 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 PRKCA "PKCA, PKCα" ENSG00000154229 "Protein kinase C alpha" P17252 17 66302613-66810743 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins" "Angiogenesis, Apoptosis, Cell adhesion" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 76.8" "Cell type enhanced" "Detected in many" "Astrocytes: 564.8;Excitatory neurons: 247.6;Inhibitory neurons: 400.0;Microglial cells: 281.1;Oligodendrocyte precursor cells: 849.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "U-87 MG: 157.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003844, HPA006563, HPA006564, CAB016290" Enhanced Approved Enhanced "Plasma membrane,Cytosol" NA NA 190000 "Cluster 14: Monocytes - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 68: Oligodendrocytes - Mixed function" Cytosol "Plasma membrane" "CAB003844: AB_562331, CAB016290: AB_628141, HPA006563: AB_1079626, HPA006564: AB_1079625" "unprognostic (3.06e-1)" "unprognostic (3.56e-2)" "unprognostic (1.38e-2)" "unprognostic (1.01e-1)" "unprognostic (1.53e-1)" "unprognostic (7.41e-3)" "unprognostic (7.43e-2)" "unprognostic (6.86e-3)" "unprognostic (4.93e-2)" "unprognostic (1.50e-1)" "unprognostic (2.09e-1)" "unprognostic (2.24e-2)" "unprognostic (5.50e-2)" "unprognostic (2.46e-1)" "unprognostic (1.83e-1)" "unprognostic (1.35e-3)" "unprognostic (8.77e-2)" 3.1 21.1 37.0 6.9 35.0 1.8 2.3 20.8 51.4 7.5 11.8 18.5 11.9 11.7 4.8 3.2 4.6 7.5 4.4 76.8 32.8 12.8 7.3 4.5 4.9 37.3 36.1 15.7 5.1 0.9 6.3 5.0 25.3 13.0 8.6 30.1 2.3 16.9 5.8 3.0 10.6 10.7 30.1 6.5 8.4 2.6 36.9 3.1 3.2 4.3 4.6 8.9 5.6 27.3 7.3 38.0 7.7 7.8 18.2 46.0 1.0 40.8 26.4 28.8 24.3 4.5 4.6 9.6 10.9 65.9 48.1 0.9 3.9 4.8 61.9 16.4 9.3 0.0 22.2 20.2 24.9 12.2 62.8 20.2 1.8 36.0 30.5 41.8 25.0 45.6 25.8 0.2 44.8 2.3 24.9 7.4 3.1 18.9 20.2 4.5 56.5 0.2 10.2 6.4 4.6 25.6 13.5 7.7 0.4 8.0 0.8 17.0 75.1 49.6 28.6 31.4 25.8 0.1 0.0 1.2 157.6 0.1 25.1 0.0 0.2 0.0 0.1 0.2 0.5 0.0 0.8 0.4 0.3 0.0 1.2 0.7 0.0 0.0 1.1 0.4 0.1 0.3 37.0 35.0 20.8 51.4 76.8 32.8 37.3 36.1 25.3 30.1 36.9 27.3 10.0 0.0 8.4 564.8 5.7 10.6 15.0 10.3 13.6 198.3 7.9 11.2 9.8 45.8 7.2 40.5 2.1 4.1 24.6 27.1 7.9 16.1 3.2 5.5 40.1 5.6 8.4 5.7 247.6 6.8 3.4 17.5 23.9 6.3 20.3 39.9 27.8 14.7 25.4 10.1 400.0 38.4 2.0 11.9 7.6 3.0 53.4 20.9 10.6 281.1 6.8 34.3 12.3 849.0 198.3 8.8 21.0 48.5 11.8 12.8 27.0 21.3 7.0 77.1 26.3 6.5 41.4 1.3 3.9 6.1 10.4 15.2 36.9 47.1 26.4 17.2 PRKCB "PKCβ, PKCB, PRKCB1, PRKCB2" ENSG00000166501 "Protein kinase C beta" P05771 16 23835983-24220611 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins, Transporters" "Adaptive immunity, Apoptosis, Immunity, Transcription, Transcription regulation" "Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 84.0;lymphoid tissue: 47.2" "Cell type enhanced" "Detected in many" "B-cells: 185.1;Bipolar cells: 208.6;Excitatory neurons: 877.7;Inhibitory neurons: 320.2;Kupffer cells: 221.9" "Low cancer specificity" "Detected in many" "Group enriched" "Detected in many" 95 "amygdala: 28.9;basal ganglia: 53.9;cerebral cortex: 84.0;hippocampal formation: 35.3;white matter: 36.6" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in some" "HEL: 161.8;HMC-1: 154.8;K-562: 234.9;THP-1: 72.7;U-937: 64.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003843, HPA048321, HPA054203" Approved Supported Nucleoplasm,Cytosol NA NA 380000 "Cluster 6: Non-specific - Transcription" "Cluster 10: Brain - Neuronal signaling" "Cluster 1: K-562 - Erythropoiesis" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm Cytosol "CAB003843: AB_562197, HPA048321: AB_2680357, HPA054203: AB_2682416" "unprognostic (1.53e-3)" "unprognostic (4.53e-4)" "unprognostic (2.52e-3)" "unprognostic (3.07e-2)" "unprognostic (1.72e-1)" "unprognostic (7.13e-3)" "unprognostic (2.06e-1)" "unprognostic (1.67e-3)" "unprognostic (3.19e-2)" "unprognostic (1.79e-1)" "unprognostic (7.38e-2)" "unprognostic (1.06e-1)" "unprognostic (3.17e-3)" "unprognostic (2.08e-1)" "unprognostic (2.12e-2)" "unprognostic (3.28e-1)" "unprognostic (4.95e-2)" 4.4 1.6 28.9 30.8 53.9 32.1 1.5 0.5 84.0 4.2 0.0 9.7 5.9 3.8 0.6 3.5 3.8 4.4 1.1 35.3 0.0 2.8 4.2 7.8 47.1 0.0 0.0 0.6 1.0 0.2 1.4 2.7 0.0 7.3 5.1 18.2 1.5 10.2 0.8 5.5 19.4 7.2 0.0 46.2 5.7 8.4 0.0 47.2 4.5 1.0 40.0 8.7 1.7 36.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 30.5 1.0 0.0 0.3 0.5 0.5 0.0 0.0 0.0 3.2 161.8 7.5 0.0 0.0 23.6 154.8 0.0 0.7 0.0 0.0 0.0 0.0 27.3 234.9 0.6 0.0 0.0 52.1 51.4 1.5 0.0 0.0 49.0 0.4 9.5 0.5 14.1 27.2 0.0 0.2 0.2 2.4 0.8 0.0 72.7 1.1 0.0 0.3 0.1 0.0 4.1 0.0 1.4 0.2 64.4 0.3 39.3 13.3 27.8 24.8 20.0 11.5 44.2 15.9 29.9 11.3 40.0 13.0 32.0 39.1 39.9 28.6 33.8 12.7 15.5 28.9 53.9 0.5 84.0 35.3 0.0 0.0 0.0 0.0 0.0 0.0 36.6 1.1 3.2 4.9 21.5 185.1 6.0 4.1 0.1 0.6 208.6 0.9 0.8 2.0 2.8 1.8 1.8 2.1 0.2 166.3 1.4 0.0 0.0 26.5 0.1 0.1 4.1 0.0 26.3 877.7 0.2 0.3 1.7 1.5 0.1 71.5 1.9 11.4 3.1 50.5 79.1 320.2 1.5 0.0 221.9 20.5 11.7 0.0 100.9 3.6 110.5 154.4 10.8 120.5 102.1 132.5 0.0 9.6 0.4 61.8 1.0 6.7 0.8 1.6 9.9 0.0 4.4 1.6 3.4 3.6 0.5 14.3 0.8 68.1 0.2 3.8 4.5 PRKCD ENSG00000163932 "Protein kinase C delta" Q05655 3 53156009-53192717 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, FDA approved drug targets, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Late spermatids: 75.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Group enriched" "Detected in all" 7 "dendritic cells: 57.0;granulocytes: 52.9;monocytes: 73.7" "Cell line enhanced" "Detected in all" "SK-BR-3: 267.7;THP-1: 194.0" "Group enriched" "Detected in all" 5 "basal ganglia: 121.4;thalamus: 334.6" "Low region specificity" "Detected in all" "HPA001863, HPA001890, CAB010469, CAB013225" Enhanced Enhanced "Endoplasmic reticulum,Golgi apparatus,Cytosol" NA NA 30000 "Cluster 52: Eosinophils - Transcription" "Cluster 64: Macrophages - Immune response" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "Endoplasmic reticulum, Golgi apparatus" "CAB010469: AB_632229, CAB013225: , HPA001863: AB_1079627, HPA001890: AB_1079628" "unprognostic (3.59e-1)" "unprognostic (4.85e-2)" "unprognostic (2.66e-2)" "unprognostic (1.90e-1)" "unprognostic (1.17e-1)" "unprognostic (6.97e-2)" "prognostic unfavorable (2.24e-4)" "prognostic favorable (9.01e-4)" "unprognostic (1.95e-2)" "unprognostic (1.42e-1)" "unprognostic (1.79e-1)" "unprognostic (2.89e-1)" "unprognostic (2.05e-1)" "unprognostic (1.73e-1)" "unprognostic (2.48e-2)" "unprognostic (2.06e-3)" "unprognostic (2.95e-3)" 46.1 59.7 10.4 45.4 11.1 90.3 28.9 4.4 11.7 25.9 7.3 43.5 54.8 9.1 39.1 32.7 42.3 32.8 19.6 12.8 11.0 25.6 8.8 44.3 46.8 9.9 8.5 13.6 33.2 20.7 8.2 20.5 7.5 39.3 41.5 2.2 25.9 31.9 6.8 34.0 55.7 16.2 9.5 54.2 65.1 20.8 9.0 16.3 41.8 9.2 62.1 44.2 23.2 12.3 33.5 14.4 5.2 8.7 35.9 21.6 46.2 20.4 25.7 24.5 23.7 34.4 31.9 86.5 8.3 45.6 42.9 14.5 34.1 49.8 20.6 75.2 23.6 50.1 18.3 32.0 23.6 64.8 103.4 17.1 35.8 25.6 23.2 21.8 22.4 9.3 9.7 11.8 36.1 85.0 7.0 81.0 13.0 51.5 23.0 7.6 13.6 20.6 25.5 72.8 8.3 6.5 15.4 267.7 39.6 24.0 22.6 194.0 31.5 11.7 14.4 15.4 19.2 18.1 33.6 45.9 27.6 116.4 22.6 51.8 73.7 50.1 3.6 71.3 2.2 6.2 2.1 2.5 57.0 8.2 2.2 2.0 52.9 6.9 47.7 16.3 2.6 24.1 10.4 11.1 4.4 11.7 12.8 11.0 9.9 8.5 7.5 9.5 9.0 12.3 4.3 3.2 23.5 2.0 25.7 29.2 26.3 8.0 23.9 0.3 11.8 4.3 6.4 14.3 16.1 14.7 0.0 3.1 24.7 61.8 3.9 8.9 34.5 18.5 4.4 2.7 26.5 5.2 3.4 10.7 16.0 6.7 54.0 17.8 5.7 8.9 3.3 2.3 44.8 1.7 4.2 37.1 4.1 47.4 43.0 75.6 9.0 41.5 10.6 20.6 44.9 2.0 8.2 1.0 0.5 13.2 55.4 6.8 25.8 19.7 64.5 13.1 16.5 0.2 6.6 6.5 12.1 23.1 3.7 23.9 27.8 8.8 10.0 10.4 23.0 34.6 PRKCE ENSG00000171132 "Protein kinase C epsilon" Q02156 2 45651345-46187990 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "Cell adhesion, Cell cycle, Cell division, Immunity" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 34.5" "Cell type enhanced" "Detected in many" "Early spermatids: 206.5;Excitatory neurons: 394.4;Inhibitory neurons: 531.9;Late spermatids: 456.4;Oligodendrocyte precursor cells: 147.8" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in many" 4 "amygdala: 18.5;basal ganglia: 20.0;cerebral cortex: 34.5;hippocampal formation: 33.1;white matter: 17.1" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "REH: 27.0;TIME: 26.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB001948, HPA008236, HPA044496" Enhanced Supported Supported "Vesicles,Plasma membrane,Intermediate filaments,Cytosol" NA NA "Cluster 37: B-cells - Transcription" "Cluster 58: Brain - Synaptic function" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Intermediate filaments, Cytosol" "Vesicles, Plasma membrane" "CAB001948: , HPA008236: , HPA044496: AB_2678959" "unprognostic (1.10e-1)" "unprognostic (1.78e-1)" "unprognostic (2.27e-1)" "prognostic unfavorable (2.42e-4)" "unprognostic (9.61e-2)" "unprognostic (5.70e-2)" "unprognostic (1.51e-1)" "prognostic favorable (9.62e-4)" "unprognostic (3.05e-1)" "unprognostic (6.72e-2)" "unprognostic (7.49e-3)" "unprognostic (9.99e-2)" "prognostic favorable (2.63e-7)" "unprognostic (1.21e-1)" "unprognostic (7.11e-2)" "unprognostic (6.43e-3)" "unprognostic (2.23e-2)" 4.4 5.6 18.5 3.7 20.0 8.0 4.2 5.5 34.5 4.6 0.0 5.7 2.6 4.4 2.3 4.1 5.7 3.0 6.2 33.1 0.0 10.0 12.5 20.1 5.7 6.0 0.2 2.8 3.3 9.4 5.2 8.3 4.4 2.9 3.3 15.4 2.7 3.0 7.6 2.7 3.5 4.1 0.0 3.9 4.1 7.6 1.1 3.1 4.9 5.3 4.2 4.9 3.4 17.1 7.7 2.7 3.8 3.8 5.8 6.7 3.1 4.9 9.5 4.3 4.5 0.7 7.0 11.3 4.8 5.5 6.1 1.8 2.5 2.8 6.1 6.9 4.4 0.1 1.8 1.5 6.5 0.9 3.8 5.8 3.0 6.5 4.7 3.6 16.0 2.4 1.6 2.6 5.0 3.8 3.8 0.5 1.3 4.2 1.4 27.0 18.3 12.4 3.9 5.1 2.6 5.7 2.4 7.6 17.1 1.4 6.1 2.6 26.8 8.2 8.5 6.1 5.1 0.0 0.0 9.3 6.7 6.3 8.4 0.0 0.5 0.7 0.3 0.1 0.4 1.5 0.2 0.2 0.8 1.8 0.5 0.1 0.1 0.4 0.6 0.3 0.0 0.3 18.5 20.0 5.5 34.5 33.1 0.0 6.0 0.2 4.4 0.0 1.1 17.1 12.6 6.4 9.2 90.4 20.7 5.0 8.4 5.0 9.1 55.3 6.4 5.7 11.9 8.6 17.2 11.0 14.6 0.5 9.3 6.1 3.9 3.7 206.5 6.8 7.0 13.8 7.7 0.4 394.4 3.8 7.2 8.7 11.2 6.9 7.0 2.9 13.2 12.5 2.8 11.8 531.9 5.8 0.0 19.0 10.7 456.4 5.3 11.5 14.2 70.3 9.4 6.5 1.0 147.8 96.0 3.6 2.9 6.0 4.2 5.3 4.1 30.2 19.3 7.6 13.1 2.9 6.4 2.8 2.3 9.0 4.8 2.9 6.8 1.2 6.2 8.8 PRKCG "MGC57564, PKCγ, PKCC, PKCG, SCA14" ENSG00000126583 "Protein kinase C gamma" P05129 19 53879190-53907652 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Biological rhythms" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, FDA approved drug targets, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 20 "brain: 103.3" "Cell type enhanced" "Detected in some" "Excitatory neurons: 22.6;Glandular and luminal cells: 5.1;Horizontal cells: 5.0;Inhibitory neurons: 12.8" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in many" "hippocampal formation: 103.3" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 2.2;OE19: 4.0;SH-SY5Y: 1.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA054560 Enhanced NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 21: OE19 - Mitochondria" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA054560: AB_2682523" "unprognostic (7.14e-2)" "unprognostic (5.42e-2)" "unprognostic (1.85e-1)" "unprognostic (3.86e-2)" "unprognostic (1.41e-1)" "unprognostic (5.38e-2)" "unprognostic (5.96e-2)" "unprognostic (4.46e-2)" "unprognostic (2.09e-1)" "unprognostic (2.64e-2)" "unprognostic (7.48e-3)" "unprognostic (2.68e-1)" "unprognostic (2.22e-7)" "unprognostic (2.41e-2)" "unprognostic (2.61e-1)" "unprognostic (1.06e-1)" "unprognostic (1.83e-1)" 0.1 0.0 47.5 0.2 44.8 0.9 0.0 5.8 64.8 0.0 0.0 0.3 0.4 0.1 0.0 0.0 0.5 0.1 0.0 103.3 4.0 0.0 0.0 0.0 0.0 0.0 3.5 0.1 1.8 3.9 1.4 0.0 0.0 0.0 0.2 0.3 0.1 0.0 0.1 0.0 0.5 0.1 0.6 0.0 0.6 5.2 12.6 3.4 0.0 0.2 0.0 0.0 0.0 18.3 0.1 2.2 0.4 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.5 0.6 0.1 0.6 0.0 0.2 0.2 1.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.9 0.0 0.0 0.2 0.0 0.4 0.0 0.5 0.0 0.0 0.0 0.2 0.2 0.0 0.3 4.0 0.1 0.4 0.2 0.0 0.4 0.0 0.0 1.5 0.6 0.0 0.0 0.7 0.7 0.0 0.4 0.0 0.7 0.0 0.0 0.6 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 47.5 44.8 5.8 64.8 103.3 4.0 0.0 3.5 0.0 0.6 12.6 18.3 1.1 0.0 0.0 1.0 0.7 0.1 0.1 0.0 0.0 0.0 2.3 4.6 0.7 0.0 0.0 0.0 0.0 0.0 0.8 0.2 0.0 0.1 4.2 1.2 2.0 0.5 0.0 0.0 22.6 0.0 0.2 0.6 2.0 5.1 0.0 0.0 0.0 0.0 0.1 5.0 12.8 1.5 0.0 0.0 0.0 1.8 0.0 0.6 0.0 2.8 0.0 0.0 0.0 3.0 2.0 0.2 0.0 0.0 1.0 0.1 0.0 0.0 0.1 0.2 0.0 4.0 0.4 2.9 0.9 0.1 0.0 0.0 0.2 0.0 0.4 0.1 PRKCH "PKC-L, PKCL, PRKCL" ENSG00000027075 "Protein kinase C eta" P24723 14 61187559-61550976 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Differentiation "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "dendritic cells: 128.4;Microglial cells: 267.9;NK-cells: 229.6;T-cells: 130.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 11 "gdT-cell: 116.5;MAIT T-cell: 91.3;memory CD4 T-cell: 88.0;memory CD8 T-cell: 137.0;naive CD4 T-cell: 106.9;naive CD8 T-cell: 105.5;NK-cell: 117.1;T-reg: 79.8" "Group enriched" "Detected in all" 14 "NK-cells: 117.1;T-cells: 137.0" "Cell line enhanced" "Detected in many" "BEWO: 81.8;HUVEC TERT2: 108.7;MOLT-4: 75.8;RT4: 46.4;TIME: 72.0" "Group enriched" "Detected in all" 6 "basal ganglia: 28.0;thalamus: 17.9" "Low region specificity" "Detected in all" "HPA026294, HPA053709" Approved Approved "Plasma membrane,Cytosol" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 3: T-cells - Adaptive immune response" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 63: NK-cells & T-cells - Immune response" Cytosol "Plasma membrane" "HPA026294: AB_10603988, HPA053709: AB_2682237" "unprognostic (1.42e-1)" "unprognostic (3.89e-3)" "unprognostic (1.78e-1)" "unprognostic (1.96e-3)" "unprognostic (1.04e-1)" "prognostic favorable (8.55e-6)" "unprognostic (1.14e-2)" "unprognostic (2.97e-2)" "unprognostic (4.14e-1)" "unprognostic (1.94e-1)" "unprognostic (7.96e-2)" "unprognostic (1.60e-1)" "unprognostic (1.52e-3)" "unprognostic (1.13e-1)" "unprognostic (4.14e-2)" "unprognostic (6.98e-2)" "unprognostic (4.73e-3)" 26.6 7.8 21.1 21.9 30.2 24.2 21.9 12.4 15.7 20.6 9.5 8.9 9.5 14.5 10.9 30.0 13.6 19.7 19.2 13.2 13.9 14.5 10.3 35.3 55.2 19.3 21.7 5.9 8.4 14.2 15.0 32.5 19.4 15.8 8.8 3.1 28.3 11.4 14.2 23.7 16.6 18.1 18.6 38.5 9.6 7.5 29.9 65.8 21.1 18.1 38.5 25.3 21.7 15.5 18.1 6.3 0.8 4.9 2.8 0.6 81.8 0.3 1.5 0.8 0.8 1.9 10.5 0.3 12.4 0.1 1.6 12.3 0.6 13.5 1.4 2.2 7.9 0.1 2.0 0.7 1.2 0.0 2.4 2.2 13.8 0.7 9.4 1.2 108.7 35.4 0.2 0.4 6.2 32.7 75.8 0.7 1.4 12.9 8.4 6.3 3.2 0.2 0.2 46.4 3.2 5.1 2.1 16.2 10.2 14.5 15.9 1.4 72.0 2.1 14.0 2.1 0.9 1.4 0.2 0.6 3.1 1.1 3.6 0.8 3.0 2.4 116.5 1.9 91.3 2.2 88.0 137.0 9.2 1.4 106.9 105.5 5.9 117.1 1.1 3.0 79.8 84.0 21.1 30.2 12.4 15.7 13.2 13.9 19.3 21.7 19.4 18.6 29.9 15.5 59.7 6.4 11.4 2.0 6.6 18.7 16.4 8.3 15.9 0.4 15.0 9.3 9.0 10.0 15.5 0.0 0.0 27.6 128.4 0.6 3.9 6.0 32.6 10.3 2.1 70.8 11.9 18.1 1.7 6.8 21.2 5.0 7.1 20.9 1.3 15.4 68.9 2.0 6.0 0.0 3.1 2.7 2.0 14.4 6.9 6.0 1.8 15.4 16.0 267.9 8.9 7.0 229.6 4.5 1.8 5.4 4.3 6.8 26.6 14.7 4.6 1.2 9.2 0.5 0.0 4.4 5.2 0.1 2.4 18.1 26.7 48.3 130.5 1.6 1.3 26.0 PRKCI "DXS1179E, PKCI" ENSG00000163558 "Protein kinase C iota" P41743 3 170222424-170305977 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, FDA approved drug targets, Proto-oncogene, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026574, HPA038635" Approved Supported "Microtubules,Cytokinetic bridge,Cytosol" Yes No "Cluster 15: NK-cells - Transcription" "Cluster 46: Fibroblasts - ECM organization" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 44: Endometrium - Transcription" Cytosol "Microtubules, Cytokinetic bridge" "HPA026574: AB_1855428, HPA038635: AB_2676124" "unprognostic (2.26e-1)" "unprognostic (6.75e-2)" "unprognostic (4.57e-2)" "prognostic unfavorable (3.93e-6)" "unprognostic (1.59e-1)" "unprognostic (1.84e-2)" "prognostic unfavorable (3.02e-4)" "unprognostic (2.52e-1)" "unprognostic (7.10e-2)" "unprognostic (1.73e-2)" "prognostic unfavorable (1.22e-4)" "unprognostic (5.32e-3)" "prognostic favorable (3.10e-4)" "unprognostic (1.16e-1)" "unprognostic (2.65e-1)" "unprognostic (1.06e-1)" "unprognostic (9.73e-2)" 6.7 5.0 2.0 6.9 2.4 2.6 10.4 2.0 3.2 12.7 0.3 12.4 11.6 11.0 8.2 15.1 15.9 11.4 6.9 3.4 1.1 13.5 7.3 16.6 4.6 0.4 0.2 13.6 7.0 13.0 3.1 10.9 0.5 17.3 13.1 6.2 17.5 12.7 6.2 6.9 10.8 11.0 0.2 5.2 34.5 12.5 0.9 10.9 24.5 9.8 10.4 16.1 6.2 1.1 81.6 20.2 20.0 21.6 17.3 23.9 32.2 20.4 29.9 26.4 28.3 29.7 38.6 24.7 65.3 28.8 36.4 37.3 37.9 40.0 44.8 18.2 23.5 22.9 24.3 16.6 27.9 20.9 10.0 21.8 27.5 22.6 35.1 42.8 20.9 13.3 25.8 19.8 27.4 28.0 30.5 8.5 42.3 86.4 22.1 21.8 30.7 41.2 42.3 24.4 31.5 25.8 44.1 57.7 20.0 29.5 63.0 14.5 22.4 27.5 21.1 26.0 34.3 33.9 34.9 35.2 19.8 16.4 11.0 0.0 0.6 0.4 1.1 0.6 1.7 0.9 1.5 2.0 0.8 1.2 1.6 0.9 0.3 2.6 0.5 0.8 1.1 0.7 2.0 2.4 2.0 3.2 3.4 1.1 0.4 0.2 0.5 0.2 0.9 1.1 17.6 73.7 82.1 23.2 5.8 57.1 49.5 39.8 30.7 16.4 29.0 19.7 16.2 24.3 45.3 49.7 14.6 30.2 15.0 29.0 25.4 16.5 8.4 42.0 29.7 20.5 29.3 10.5 77.2 22.0 26.6 32.2 59.7 72.3 8.8 20.4 17.5 17.7 10.0 15.2 55.2 28.3 50.8 18.6 26.8 6.8 23.3 11.6 17.8 22.5 12.7 8.8 6.2 33.2 33.5 55.2 18.6 28.6 29.4 99.4 18.7 20.4 31.9 9.4 19.7 23.7 18.7 15.8 20.6 38.5 63.6 20.7 14.8 14.3 28.5 80.1 PRKCQ ENSG00000065675 "Protein kinase C theta" Q04759 10 6427143-6580301 "Cancer-related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Immunity, Inflammatory response" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "lymphoid tissue: 33.6;skeletal muscle: 124.5;tongue: 112.6" "Cell type enhanced" "Detected in many" "Astrocytes: 22.9;dendritic cells: 22.4;NK-cells: 32.0;Oligodendrocyte precursor cells: 24.6;Oligodendrocytes: 75.2;T-cells: 31.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 9 "gdT-cell: 23.0;MAIT T-cell: 18.0;memory CD4 T-cell: 24.5;memory CD8 T-cell: 24.5;naive CD4 T-cell: 19.1;naive CD8 T-cell: 17.9;NK-cell: 13.3;T-reg: 39.7" "Group enriched" "Detected in many" 11 "NK-cells: 13.3;T-cells: 39.7" "Cell line enhanced" "Detected in many" "HEL: 57.8;JURKAT: 40.0;MOLT-4: 43.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA065279, HPA073098" Enhanced "Centriolar satellite" NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 24: Non-specific - Transcription regulation" "Centriolar satellite" "HPA065279: AB_2685453, HPA073098: AB_2686571" "unprognostic (6.61e-3)" "unprognostic (2.12e-1)" "unprognostic (1.87e-1)" "unprognostic (1.48e-1)" "unprognostic (1.50e-1)" "unprognostic (2.24e-1)" "unprognostic (2.69e-3)" "unprognostic (2.46e-1)" "unprognostic (8.40e-2)" "unprognostic (2.66e-1)" "unprognostic (1.17e-1)" "unprognostic (3.22e-1)" "unprognostic (5.26e-2)" "unprognostic (7.74e-2)" "unprognostic (2.79e-1)" "prognostic unfavorable (5.27e-4)" "unprognostic (3.51e-2)" 0.8 0.7 5.3 5.2 8.5 5.7 0.9 6.1 6.3 1.6 12.1 1.4 1.5 2.5 8.3 2.2 3.9 1.5 0.3 5.5 8.2 10.9 1.0 5.3 12.3 6.5 8.6 1.3 3.4 0.7 0.8 0.2 6.4 1.8 1.7 1.5 1.4 1.1 124.5 0.3 3.3 0.7 5.5 5.0 2.1 1.1 7.2 33.6 14.9 112.6 9.4 2.2 0.6 9.8 0.1 5.3 0.1 0.0 0.0 0.0 1.6 0.0 0.0 0.2 0.2 0.4 3.4 0.3 0.0 0.0 0.0 0.0 3.3 6.0 0.0 0.0 3.9 57.8 0.0 0.4 0.7 2.8 0.6 0.3 3.5 0.1 0.2 0.0 0.5 40.0 12.8 0.1 0.0 0.0 43.9 8.0 5.8 0.5 0.0 8.5 1.3 0.0 11.6 2.9 0.4 2.1 0.0 0.0 0.0 3.4 0.0 5.8 0.0 0.0 5.6 0.0 0.0 0.1 0.0 0.0 0.0 7.1 0.0 2.4 0.1 0.3 23.0 0.4 18.0 0.1 24.5 24.5 0.2 0.0 19.1 17.9 1.6 13.3 0.0 0.0 39.7 10.5 5.3 8.5 6.1 6.3 5.5 8.2 6.5 8.6 6.4 5.5 7.2 9.8 0.2 3.2 7.0 22.9 0.8 0.0 0.3 0.3 0.6 1.6 0.3 0.3 0.4 0.0 0.7 1.8 0.0 0.0 22.4 0.0 7.9 0.3 2.1 0.5 1.2 0.2 1.8 8.0 13.7 0.8 0.1 0.7 1.5 3.0 1.3 8.2 1.1 0.0 0.5 0.0 14.7 0.5 0.0 1.3 0.5 5.6 0.0 1.7 0.0 7.5 0.8 1.2 32.0 24.6 75.2 0.1 0.1 0.0 10.2 0.2 0.0 0.3 0.9 0.4 0.0 4.2 0.4 1.0 2.2 0.5 0.0 0.0 31.7 0.3 0.4 0.1 PRKCZ PKC2 ENSG00000067606 "Protein kinase C zeta" Q05513 1 2050411-2185395 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Inflammatory response" "Kinase, Serine/threonine-protein kinase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 58.0" "Group enriched" "Detected in many" 4 "Late spermatids: 708.3;Syncytiotrophoblasts: 1107.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 6 "eosinophil: 16.3" "Lineage enriched" "Detected in many" 6 "granulocytes: 16.3" "Cell line enhanced" "Detected in many" "BEWO: 44.5;OE19: 41.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA021851 Enhanced Supported "Plasma membrane,Cytosol" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 6: Brain - Smell perception" "Cluster 28: BEWO - Transcription regulation" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" Cytosol "Plasma membrane" "HPA021851: AB_1855433" "unprognostic (1.25e-2)" "unprognostic (2.61e-1)" "unprognostic (5.10e-2)" "unprognostic (1.14e-2)" "unprognostic (2.08e-1)" "unprognostic (3.61e-2)" "unprognostic (1.73e-2)" "unprognostic (5.13e-2)" "unprognostic (1.18e-1)" "unprognostic (3.10e-1)" "unprognostic (1.12e-1)" "unprognostic (2.86e-1)" "prognostic favorable (1.64e-9)" "unprognostic (3.57e-2)" "unprognostic (3.27e-2)" "unprognostic (1.39e-1)" "unprognostic (7.85e-2)" 1.7 11.1 23.6 4.6 25.7 2.1 5.6 58.0 41.3 4.3 0.0 13.2 29.3 2.2 7.8 16.0 9.5 4.4 9.7 23.7 10.2 16.0 11.0 31.6 8.0 18.6 8.3 2.7 12.5 14.7 17.6 43.8 19.0 8.4 11.3 14.8 10.8 3.9 0.3 13.8 28.0 1.6 5.6 10.5 8.9 31.9 7.2 3.7 21.8 0.6 7.8 5.8 8.0 24.8 14.7 9.7 3.4 17.2 0.0 0.0 44.5 1.2 0.5 11.1 0.7 23.8 31.0 0.1 27.4 3.9 9.4 25.4 20.5 25.5 7.9 1.0 21.8 0.0 15.2 33.5 3.2 0.1 11.0 0.6 14.9 0.0 8.6 0.0 0.0 4.0 6.6 0.2 0.2 17.9 0.9 0.0 6.4 41.9 22.5 0.0 0.0 5.1 18.6 16.0 24.1 18.7 11.6 27.5 5.2 28.7 17.7 4.0 0.0 0.1 13.1 0.1 0.1 6.8 1.3 0.3 1.2 0.3 16.8 0.3 0.0 16.3 0.5 0.3 2.5 0.3 0.9 0.6 0.0 0.4 0.8 0.3 1.1 0.9 0.0 0.3 0.9 0.3 23.6 25.7 58.0 41.3 23.7 10.2 18.6 8.3 19.0 5.6 7.2 24.8 0.9 121.8 72.2 2.3 6.5 13.0 11.8 11.0 10.2 27.1 11.3 11.0 1.4 5.7 21.1 7.3 4.2 118.7 7.5 48.9 7.9 12.3 224.4 14.0 4.7 6.3 10.2 6.6 39.5 10.7 66.3 3.1 17.9 11.7 8.2 12.5 10.0 16.5 14.5 62.2 35.2 25.5 10.2 0.8 2.9 708.3 9.6 4.4 7.2 2.8 4.5 19.1 8.2 13.0 41.3 14.2 45.7 8.6 7.4 19.5 78.4 24.7 22.1 25.9 0.0 0.3 4.1 28.3 28.4 13.4 13.4 1107.9 9.8 2.6 31.3 14.3 PRKD1 "PKC-mu, PKCM, PKD, PRKCM" ENSG00000184304 "Protein kinase D1" Q15139 14 29576479-30191898 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Angiogenesis, Apoptosis, Differentiation, Immunity, Inflammatory response, Innate immunity, Neurogenesis" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Ectodermal dysplasia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 362.1;Excitatory neurons: 147.4;Inhibitory neurons: 171.1;Microglial cells: 89.0;Oligodendrocyte precursor cells: 390.6" "Cancer enhanced" "Detected in all" "prostate cancer: 10.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC diff: 21.6;fHDF/TERT166: 19.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB018367, HPA029834" Uncertain Supported "Plasma membrane,Cytosol" "Intracellular and membrane" NA NA "Cluster 21: Non-specific - Transcription" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 68: Oligodendrocytes - Mixed function" "Plasma membrane" Cytosol "CAB018367: AB_2253119, HPA029834: AB_10602821" "unprognostic (5.35e-2)" "unprognostic (3.20e-1)" "unprognostic (2.27e-2)" "unprognostic (6.70e-2)" "unprognostic (2.37e-1)" "unprognostic (1.92e-1)" "unprognostic (1.08e-3)" "unprognostic (8.88e-2)" "unprognostic (2.37e-2)" "unprognostic (5.29e-2)" "unprognostic (7.08e-2)" "unprognostic (1.56e-1)" "prognostic favorable (2.44e-5)" "unprognostic (9.45e-4)" "unprognostic (1.99e-1)" "prognostic unfavorable (2.91e-4)" "unprognostic (3.89e-1)" 8.0 9.6 5.6 2.2 8.0 0.0 7.7 6.5 6.7 6.4 3.7 9.5 1.0 7.9 3.5 2.1 6.5 4.4 6.1 7.5 7.5 17.5 1.6 7.5 0.3 8.6 8.6 11.2 5.4 10.6 5.6 1.9 8.7 14.7 1.3 4.7 2.9 9.3 1.6 2.8 3.6 6.3 8.9 2.3 4.6 11.7 8.1 2.4 5.9 2.6 0.5 13.1 4.6 10.3 0.0 4.4 4.8 3.1 21.6 16.5 0.1 14.1 10.4 16.7 7.3 0.0 0.3 0.0 1.9 19.4 4.0 0.1 7.9 2.1 6.8 0.0 6.2 0.0 0.0 0.5 8.8 0.0 0.1 18.4 0.3 1.4 1.5 6.1 2.6 0.0 1.4 0.4 17.4 1.8 0.0 0.0 2.6 0.0 9.6 0.0 6.3 5.2 9.7 6.6 4.3 13.0 2.6 0.0 4.5 4.6 0.0 0.1 5.6 13.6 6.7 1.0 3.7 0.0 0.0 0.0 3.5 0.0 14.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.6 8.0 6.5 6.7 7.5 7.5 8.6 8.6 8.7 8.9 8.1 10.3 4.6 0.0 7.4 362.1 0.2 0.5 4.8 0.4 0.6 1.4 1.4 1.5 1.2 10.0 0.0 12.9 6.2 0.0 0.0 0.1 29.4 2.4 39.5 2.8 9.2 6.1 3.0 2.7 147.4 4.2 0.1 6.4 0.5 8.4 0.0 18.7 10.8 2.5 0.2 1.7 171.1 0.2 0.0 1.6 0.9 16.9 7.5 0.7 7.2 89.0 0.0 16.7 0.0 390.6 76.6 2.0 0.1 12.8 0.4 12.4 0.2 4.5 0.1 2.9 0.0 13.3 4.5 3.2 7.8 0.0 0.9 0.3 0.6 29.6 0.1 1.3 PRKD2 "DKFZP586E0820, HSPC187, PKD2" ENSG00000105287 "Protein kinase D2" Q9BZL6 19 46674275-46717127 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Adaptive immunity, Angiogenesis, Cell adhesion, Immunity" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "U-266/84: 149.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021490, HPA056727" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 64: Macrophages - Immune response" "Cluster 16: U-266 - Nucleosome" "Cluster 57: B-cells - Immune response" Nucleoplasm Cytosol "HPA021490: AB_1855708, HPA056727: AB_2683217" "unprognostic (3.01e-2)" "unprognostic (1.22e-2)" "unprognostic (1.23e-3)" "unprognostic (7.06e-2)" "unprognostic (8.91e-2)" "unprognostic (1.99e-2)" "unprognostic (8.79e-3)" "unprognostic (2.61e-1)" "unprognostic (6.22e-2)" "unprognostic (4.21e-3)" "unprognostic (8.89e-2)" "unprognostic (2.74e-1)" "unprognostic (3.45e-3)" "unprognostic (1.04e-2)" "unprognostic (7.19e-2)" "unprognostic (4.34e-2)" "prognostic favorable (9.15e-4)" 29.0 11.5 7.2 23.6 7.3 29.4 29.3 5.4 7.7 26.6 12.5 20.3 17.1 21.8 4.7 27.5 24.1 11.2 13.8 6.1 6.0 19.2 13.8 34.3 31.1 10.0 6.3 21.8 19.1 8.3 24.0 11.1 6.8 23.9 7.1 4.4 24.7 10.0 8.0 46.8 29.9 6.0 6.0 54.3 20.3 6.6 7.7 25.6 28.9 4.8 21.2 19.5 26.9 6.6 19.6 34.5 12.8 16.6 7.3 6.4 15.1 11.5 13.2 19.6 19.7 19.7 21.0 22.3 16.3 13.2 13.2 27.5 9.5 26.0 5.9 19.8 17.5 25.9 11.5 10.2 12.8 21.2 34.7 11.0 15.8 12.7 9.8 12.8 30.1 21.5 14.6 35.4 7.0 23.8 32.7 53.1 9.7 27.4 17.4 25.8 5.8 37.5 11.4 32.7 7.7 22.4 18.8 18.8 4.6 10.6 11.6 7.5 17.6 8.7 18.8 7.1 10.0 31.8 149.1 13.5 8.5 17.7 11.0 0.6 0.7 2.6 3.9 0.7 3.3 4.3 3.9 4.3 0.3 4.1 3.3 3.3 5.3 2.2 0.5 0.0 2.9 1.5 7.2 7.3 5.4 7.7 6.1 6.0 10.0 6.3 6.8 6.0 7.7 6.6 37.8 9.6 9.9 5.9 46.5 22.0 32.0 13.2 22.8 6.4 13.9 11.3 17.2 12.8 13.0 9.2 0.0 13.8 17.5 43.6 7.9 18.6 1.2 15.3 6.7 37.2 21.6 4.0 6.5 28.2 13.8 9.6 23.4 15.0 14.5 14.1 37.1 8.5 9.0 1.7 2.8 21.7 4.1 12.3 11.4 3.1 11.8 8.3 12.4 11.2 9.3 6.5 42.2 4.0 3.1 29.5 35.1 6.8 47.0 22.9 34.1 9.3 15.6 4.4 13.1 6.1 7.6 2.9 17.9 21.2 26.7 29.7 31.9 6.6 15.3 30.2 PRKD3 "EPK2, PRKCN" ENSG00000115825 "Protein kinase D3" O94806 2 37250502-37324833 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "SK-MEL-30: 152.1;U-266/84: 159.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA029529 Uncertain Approved Nucleoplasm,Cytosol NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 16: U-266 - Nucleosome" "Cluster 46: Photoreceptor cells - Phototransduction" "Nucleoplasm, Cytosol" "HPA029529: AB_10602082" "unprognostic (1.39e-1)" "unprognostic (7.34e-2)" "prognostic favorable (4.84e-4)" "unprognostic (1.23e-2)" "unprognostic (5.61e-2)" "unprognostic (2.08e-1)" "prognostic unfavorable (3.47e-4)" "unprognostic (1.10e-1)" "unprognostic (1.16e-1)" "unprognostic (2.52e-2)" "unprognostic (2.93e-1)" "unprognostic (1.81e-1)" "unprognostic (7.62e-3)" "unprognostic (2.49e-2)" "unprognostic (1.18e-1)" "unprognostic (1.36e-1)" "unprognostic (1.35e-1)" 15.1 19.9 6.1 18.1 6.8 8.7 14.4 7.8 7.3 19.3 3.9 16.4 8.2 18.9 13.8 10.7 9.9 13.3 9.8 6.0 7.5 12.0 10.1 14.7 29.1 7.2 7.1 18.0 9.1 11.7 6.5 14.9 7.8 11.7 11.0 41.6 10.5 12.5 14.9 12.2 10.3 16.2 7.6 23.4 12.4 23.3 8.1 20.7 13.4 12.1 28.9 15.5 9.5 7.1 38.8 14.3 44.4 36.1 33.2 55.1 31.5 25.0 48.8 29.1 28.7 23.4 14.0 58.5 20.1 39.6 43.2 15.0 31.1 31.9 39.0 72.3 38.7 39.2 24.4 17.8 13.8 26.2 21.5 26.0 16.2 46.2 29.7 26.6 52.6 19.9 32.3 70.9 33.8 6.1 11.6 21.6 45.4 0.4 14.2 40.8 67.9 51.8 18.9 42.1 32.5 81.0 24.6 13.9 152.1 22.8 15.1 25.1 47.7 80.0 40.5 31.5 28.5 78.1 159.7 68.2 27.8 11.2 48.7 6.9 7.7 6.1 9.5 6.7 8.1 10.6 8.5 8.1 7.7 14.6 9.6 10.8 1.4 6.9 3.6 8.1 4.4 3.6 6.1 6.8 7.8 7.3 6.0 7.5 7.2 7.1 7.8 7.6 8.1 7.1 41.4 41.7 17.8 21.9 60.2 37.9 32.1 24.1 14.8 47.6 14.7 15.5 9.1 27.1 16.6 18.4 68.8 11.2 37.7 7.3 3.9 13.1 57.1 8.3 38.5 48.0 18.8 12.0 24.8 10.6 37.0 33.0 20.4 14.1 76.9 26.8 44.3 12.2 12.8 43.7 18.7 6.9 22.4 31.2 91.2 100.6 33.5 24.4 49.8 68.4 32.7 15.9 27.8 37.7 12.6 16.1 4.3 30.9 60.2 34.3 6.6 8.6 10.3 118.8 26.3 27.5 24.0 54.7 39.9 10.6 23.9 9.7 33.5 29.1 12.3 34.1 PRKDC "DNA-PKC, DNA-PKcs, DNAPK, DNAPKc, DNPK1, HYRC, HYRC1, p350, p460, XRCC7" ENSG00000253729 "Protein kinase, DNA-activated, catalytic subunit" P78527 8 47773111-47960178 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Biological rhythms, DNA damage, DNA recombination, DNA repair, Immunity, Innate immunity, Ribosome biogenesis" "DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, SCID" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB005167, HPA035174" Supported Enhanced Nucleoplasm NA NA 250000 "Cluster 6: Non-specific - Transcription" "Cluster 59: Non-specific - Translation" "Cluster 36: HEL - Hemostasis" "Cluster 36: Stromal cells - Cell proliferation" Nucleoplasm "CAB005167: AB_2172845, HPA035174: AB_2674504" "unprognostic (3.14e-2)" "unprognostic (3.02e-3)" "unprognostic (1.56e-2)" "prognostic unfavorable (1.03e-4)" "unprognostic (8.95e-2)" "unprognostic (1.34e-1)" "unprognostic (7.70e-3)" "unprognostic (5.74e-2)" "unprognostic (1.12e-2)" "unprognostic (1.60e-2)" "unprognostic (7.76e-3)" "unprognostic (7.77e-2)" "unprognostic (2.84e-2)" "unprognostic (2.32e-1)" "unprognostic (2.20e-1)" "unprognostic (6.76e-3)" "unprognostic (2.15e-2)" 17.3 16.8 8.6 14.1 10.7 19.2 16.1 9.8 11.9 18.2 10.8 16.2 7.0 20.1 8.0 24.0 18.3 7.4 16.7 10.6 9.3 14.8 14.0 14.8 17.9 10.4 10.0 19.8 18.0 14.0 16.3 10.9 9.8 13.5 11.6 23.8 16.0 9.2 26.4 19.8 17.2 12.1 10.6 18.8 16.6 18.3 9.6 27.8 13.4 15.0 17.1 18.7 17.5 14.3 123.5 103.4 98.4 93.9 59.9 63.0 41.6 51.2 49.9 70.3 68.9 68.0 39.6 117.1 43.1 63.3 52.3 68.5 131.3 70.2 109.3 26.3 81.8 230.2 92.1 83.7 25.8 88.6 46.0 45.9 22.5 111.3 115.3 27.1 73.4 79.5 156.6 48.0 78.8 57.7 125.8 72.3 108.6 85.6 31.2 60.8 77.3 41.2 35.5 104.4 49.2 62.5 158.1 50.6 51.1 60.2 72.6 60.1 86.2 91.5 78.0 73.0 104.2 41.3 56.7 162.8 51.7 97.9 75.6 11.4 8.1 4.1 8.7 6.8 11.0 13.1 10.8 9.2 6.5 16.7 11.2 10.3 7.7 12.8 13.7 15.3 8.3 2.9 8.6 10.7 9.8 11.9 10.6 9.3 10.4 10.0 9.8 10.6 9.6 14.3 73.4 38.5 36.1 56.8 67.9 38.4 48.3 59.7 77.4 103.4 63.1 64.0 82.1 22.8 44.1 42.3 125.1 61.1 81.9 17.5 17.6 41.9 29.0 66.0 166.5 59.7 25.8 147.6 85.5 36.0 60.6 73.2 55.0 72.6 45.6 105.1 32.5 41.2 35.9 104.3 77.1 31.2 38.7 45.5 20.1 15.5 56.8 54.6 19.6 61.8 63.6 73.1 57.7 82.0 76.0 34.9 16.6 69.6 69.3 57.1 13.2 23.5 50.1 111.6 52.6 91.2 69.3 100.7 106.3 85.3 40.6 33.0 71.0 143.2 55.2 36.4 PRKG1 "PGK, PKG, PKG1, PRKG1B, PRKGR1B" ENSG00000185532 "Protein kinase cGMP-dependent 1" Q13976 10 50990888-52298423 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Allosteric enzyme, Kinase, Serine/threonine-protein kinase, Transferase" "Aortic aneurysm, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "tongue: 36.1" "Cell type enhanced" "Detected in many" "Astrocytes: 778.3;Excitatory neurons: 244.9;Inhibitory neurons: 473.0;Microglial cells: 188.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 36 "basophil: 7.3" "Lineage enriched" "Detected in single" 49 "granulocytes: 7.3" "Cell line enhanced" "Detected in many" "AN3-CA: 14.3;BJ hTERT+: 19.2;fHDF/TERT166: 16.1;U-138 MG: 11.2;U-87 MG: 10.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007699, CAB009629" Enhanced Approved Vesicles,Cytosol NA NA "Cluster 34: Basophils - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Vesicles, Cytosol" "CAB009629: AB_2170663, HPA007699: AB_1079677" "unprognostic (3.94e-2)" "unprognostic (2.60e-1)" "unprognostic (1.44e-2)" "unprognostic (5.36e-2)" "unprognostic (1.25e-1)" "unprognostic (1.86e-1)" "unprognostic (5.54e-1)" "unprognostic (2.23e-1)" "unprognostic (4.94e-1)" "unprognostic (2.05e-2)" "unprognostic (1.22e-2)" "unprognostic (3.40e-1)" "unprognostic (9.26e-2)" "unprognostic (5.50e-3)" "unprognostic (4.24e-2)" "unprognostic (1.11e-1)" "unprognostic (3.78e-4)" 7.0 8.3 6.4 2.7 7.2 0.6 3.1 1.4 6.9 10.3 12.4 5.5 2.4 10.3 3.5 5.2 5.2 7.0 14.1 6.6 10.7 3.8 1.7 6.8 1.2 5.1 4.6 4.2 1.7 9.6 1.3 10.1 3.2 6.4 5.3 3.6 4.0 8.1 25.8 1.0 3.4 14.6 5.3 2.5 3.3 1.8 12.2 1.5 7.0 36.1 0.9 5.4 4.2 2.7 0.1 0.2 1.7 14.3 6.5 6.0 0.1 5.4 19.2 2.1 2.6 0.1 0.9 0.3 0.0 16.1 2.0 0.1 0.0 0.1 1.7 0.0 5.0 1.0 0.3 0.0 5.5 0.0 0.1 8.1 0.1 4.8 0.1 0.6 0.0 0.0 0.0 0.1 5.3 0.1 0.0 0.0 4.1 0.0 2.5 0.0 3.9 0.0 0.0 0.0 0.0 7.1 0.0 0.0 0.1 2.0 0.1 0.0 0.0 11.2 1.9 5.9 3.7 1.5 0.8 0.0 10.0 0.0 2.5 7.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 6.4 7.2 1.4 6.9 6.6 10.7 5.1 4.6 3.2 5.3 12.2 2.7 10.5 16.0 10.8 778.3 0.3 0.9 1.7 0.0 7.4 5.9 2.8 9.4 31.4 0.0 0.0 3.7 0.0 1.0 0.3 2.9 0.0 2.4 56.0 0.4 14.7 7.1 0.0 3.4 244.9 3.6 1.2 24.2 0.5 0.5 4.5 0.1 5.0 0.0 0.4 0.0 473.0 4.2 0.0 0.0 2.2 53.0 32.6 5.3 3.6 188.3 0.0 23.6 0.0 24.6 8.0 4.8 14.1 39.5 0.1 0.5 3.2 0.2 0.9 1.3 39.5 3.9 69.9 0.9 0.9 1.6 0.6 2.2 0.2 7.9 3.6 1.0 PRKG2 "cGKII, PKG2, PRKGR2" ENSG00000138669 "Protein kinase cGMP-dependent 2" Q13237 4 81087370-81215117 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 13.1;prostate: 9.6" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 35.3;Excitatory neurons: 32.6;Inhibitory neurons: 66.1;Oligodendrocyte precursor cells: 106.6;Proximal enterocytes: 19.7;Smooth muscle cells: 29.8" "Group enriched" "Detected in some" 4 "melanoma: 4.1;prostate cancer: 2.3" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "ASC diff: 5.0;ASC TERT1: 3.8;HEL: 21.2;hTCEpi: 4.0;SCLC-21H: 6.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA007386, CAB018739" Approved NA NA "Cluster 46: Basophils - DNA binding" "Cluster 56: Intestine - Transmembrane transport" "Cluster 36: HEL - Hemostasis" "Cluster 10: Non-specific - Unknown function" "CAB018739: AB_2284387, HPA007386: AB_1079678" "unprognostic (6.14e-2)" "unprognostic (2.77e-1)" "unprognostic (2.14e-1)" "unprognostic (5.01e-4)" "unprognostic (4.33e-2)" "unprognostic (6.85e-2)" "unprognostic (1.13e-1)" "unprognostic (5.57e-2)" "unprognostic (2.05e-1)" "unprognostic (1.86e-1)" "unprognostic (4.70e-2)" "unprognostic (1.48e-1)" "unprognostic (8.27e-2)" "unprognostic (2.33e-1)" "unprognostic (1.58e-1)" "unprognostic (4.00e-3)" "unprognostic (1.06e-1)" 1.0 0.2 2.1 0.2 1.5 0.5 1.5 0.5 1.7 1.0 0.0 2.4 9.6 0.4 0.3 2.8 0.3 0.2 4.3 1.5 1.6 0.5 0.0 3.3 0.2 3.5 2.7 0.0 1.4 0.0 2.2 0.0 3.8 9.6 2.8 0.3 0.3 3.4 0.0 1.2 13.1 0.5 2.2 0.0 0.9 0.9 6.0 1.0 0.9 0.0 0.4 0.5 0.6 1.0 0.1 0.3 0.1 0.0 5.0 3.8 0.0 0.3 0.0 0.0 0.0 0.4 2.4 0.0 0.2 0.9 0.0 0.1 0.3 1.5 0.0 0.4 0.0 21.2 0.6 0.1 0.0 0.0 0.0 0.5 4.0 0.0 0.0 1.0 0.0 0.6 0.0 0.6 0.0 0.0 0.0 0.1 0.9 0.6 0.4 0.0 0.0 0.1 0.0 0.9 6.3 0.0 0.0 0.2 0.0 0.3 0.5 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.0 0.0 2.1 1.5 0.5 1.7 1.5 1.6 3.5 2.7 3.8 2.2 6.0 1.0 0.3 35.3 2.6 1.0 0.3 0.0 0.9 0.1 1.2 0.0 0.3 0.1 4.9 0.0 2.0 0.0 0.0 0.0 0.1 5.5 0.0 0.2 10.3 0.3 0.6 0.1 0.0 8.0 32.6 0.0 0.1 2.5 0.0 0.1 1.3 0.1 0.0 0.0 0.1 0.0 66.1 1.7 0.0 0.0 0.0 2.2 0.0 0.1 0.0 12.2 0.1 0.0 0.0 106.6 1.1 0.9 9.2 0.0 0.5 0.8 19.7 0.2 0.8 0.0 0.0 0.1 29.8 0.0 1.3 0.8 0.1 0.0 0.4 0.0 0.7 0.3 PRKN "AR-JP, PARK2, parkin, PDJ" ENSG00000185345 "Parkin RBR E3 ubiquitin protein ligase" O60260 6 161347417-162727775 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Autophagy, Transcription, Transcription regulation, Ubl conjugation pathway" Transferase "Disease variant, Neurodegeneration, Parkinson disease, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 28.3;tongue: 15.9" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 9.6;Alveolar cells type 2: 4.8;Distal tubular cells: 19.6;Proximal tubular cells: 6.8" "Cancer enhanced" "Detected in many" "renal cancer: 3.3" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in some" "AN3-CA: 2.0;HEL: 4.1;HSkMC: 1.7;Karpas-707: 2.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB016257, HPA036012" Enhanced Supported "Nuclear speckles,Cytosol" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 47: Non-specific - Unknown function" "Cluster 36: HEL - Hemostasis" "Cluster 39: Non-specific - Basic cellular processes" "Nuclear speckles" Cytosol "CAB016257: AB_628104, HPA036012: AB_2732471" "unprognostic (9.23e-2)" "unprognostic (3.29e-2)" "unprognostic (6.48e-2)" "unprognostic (2.69e-3)" "unprognostic (9.85e-2)" "unprognostic (5.85e-2)" "unprognostic (7.07e-2)" "unprognostic (1.12e-1)" "unprognostic (1.39e-1)" "unprognostic (2.68e-2)" "unprognostic (1.03e-3)" "unprognostic (8.16e-2)" "prognostic favorable (6.75e-12)" "unprognostic (9.93e-2)" "unprognostic (1.51e-1)" "unprognostic (5.24e-2)" "unprognostic (2.50e-1)" 3.4 3.3 4.1 0.1 3.6 0.3 1.9 0.4 5.7 1.3 0.6 2.7 1.2 1.6 1.2 3.2 1.2 1.5 9.1 4.6 1.8 5.2 1.2 1.0 0.5 1.0 1.9 2.8 1.2 2.3 1.8 0.4 1.6 1.2 0.6 1.5 1.3 1.4 28.3 2.0 1.0 1.2 1.0 1.0 1.9 5.3 1.9 0.5 1.3 15.9 0.3 2.5 1.0 2.4 0.0 0.0 0.3 2.0 0.4 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.5 0.0 0.3 0.0 0.1 0.0 0.0 0.1 0.5 4.1 0.1 0.6 0.3 0.0 0.0 1.7 0.0 0.0 0.2 0.3 0.0 0.2 0.2 2.2 0.0 0.2 0.0 0.0 0.0 0.2 0.8 0.0 0.0 0.7 0.0 0.0 0.5 1.0 0.0 0.2 0.2 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.7 1.7 0.3 2.2 0.8 0.1 1.3 0.6 0.8 0.9 0.7 1.6 1.8 1.8 0.5 0.6 0.4 0.0 0.1 0.8 4.1 3.6 0.4 5.7 4.6 1.8 1.0 1.9 1.6 1.0 1.9 2.4 2.3 9.6 4.8 0.0 0.6 0.0 0.0 0.0 0.0 0.0 2.1 1.5 0.0 0.0 1.8 1.8 0.0 0.5 0.4 0.0 19.6 1.1 0.0 3.4 1.8 0.7 0.0 0.0 0.0 2.2 0.1 1.8 0.0 3.2 2.5 3.3 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 6.8 1.5 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.3 0.4 3.7 0.0 0.0 PRKX PKX1 ENSG00000183943 "Protein kinase X-linked" P51817 X 3604340-3713649 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Angiogenesis, Differentiation" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "thyroid gland: 33.8" "Cell type enhanced" "Detected in many" "dendritic cells: 108.3;Endometrial ciliated cells: 164.0;Glandular and luminal cells: 179.5;NK-cells: 139.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 11.0" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HMC-1: 74.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA015324 Supported Supported Nucleoplasm No No "Cluster 41: Basophils - Cellular respiration" "Cluster 21: Non-specific - Transcription" "Cluster 3: HMC-1 - Innate immune response" "Cluster 44: Endometrium - Transcription" Nucleoplasm "HPA015324: AB_1855715" "unprognostic (1.07e-1)" "unprognostic (1.23e-2)" "unprognostic (1.57e-1)" "unprognostic (3.63e-1)" "unprognostic (2.45e-1)" "unprognostic (3.33e-2)" "unprognostic (1.47e-1)" "unprognostic (1.33e-2)" "unprognostic (4.14e-1)" "unprognostic (1.68e-1)" "unprognostic (2.68e-1)" "unprognostic (2.92e-1)" "unprognostic (1.07e-3)" "unprognostic (2.15e-2)" "unprognostic (9.91e-2)" "unprognostic (2.52e-1)" "unprognostic (1.70e-2)" 5.5 1.6 10.0 9.8 12.9 7.7 7.9 12.6 8.8 7.8 12.7 6.5 5.1 4.6 9.6 13.9 19.4 4.4 3.7 8.3 14.3 15.6 1.8 9.0 12.8 18.1 13.8 4.0 4.4 3.1 2.0 5.3 15.8 3.8 6.1 1.7 6.1 5.9 2.2 12.0 6.3 3.7 14.5 12.4 4.0 6.8 15.3 15.4 33.8 3.2 9.9 4.5 12.4 17.1 9.1 8.3 22.4 16.7 4.2 5.6 20.5 5.3 2.1 2.6 3.5 12.4 6.1 0.7 5.3 4.3 5.4 6.2 21.1 16.1 4.5 10.2 14.7 10.0 6.7 0.2 4.4 13.0 74.7 3.8 16.8 2.8 10.3 7.1 25.7 12.3 11.8 12.7 8.6 8.0 15.0 11.7 15.0 7.0 9.4 27.7 21.5 17.2 20.6 7.6 14.9 9.6 5.6 3.6 5.5 35.1 2.8 10.3 14.2 2.2 3.8 3.7 3.6 0.3 0.7 11.6 1.3 11.6 5.8 11.0 2.0 1.2 2.3 2.4 2.4 1.6 2.4 2.2 1.6 1.5 1.9 2.1 0.5 2.4 3.2 1.9 1.8 1.2 10.0 12.9 12.6 8.8 8.3 14.3 18.1 13.8 15.8 14.5 15.3 17.1 32.0 3.2 9.4 7.8 35.5 21.4 22.3 9.7 21.6 1.8 14.4 9.1 1.6 30.0 10.1 5.5 0.0 30.8 108.3 8.8 13.7 10.8 11.9 164.0 23.8 19.7 4.8 7.2 1.3 3.1 5.8 10.4 6.1 179.5 85.1 11.8 13.2 2.3 16.9 1.7 20.2 13.5 24.4 19.4 24.1 49.2 19.9 29.0 5.4 39.4 53.4 2.2 139.0 11.1 7.0 5.6 13.1 21.8 38.2 29.0 10.7 6.1 18.0 0.6 32.9 46.4 12.4 1.3 21.6 34.1 26.9 7.8 63.5 10.6 23.6 20.4 PRMT1 "ANM1, HCP1, HRMT1L2" ENSG00000126457 "Protein arginine methyltransferase 1" Q99873 19 49675786-49689029 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Basal respiratory cells: 444.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB022550, HPA069769, HPA072136" Supported Supported Nucleoplasm NA NA 8500 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "CAB022550: , HPA069769: AB_2686193, HPA072136: AB_2686490" "unprognostic (1.88e-2)" "unprognostic (1.28e-2)" "unprognostic (3.00e-2)" "unprognostic (3.84e-1)" "unprognostic (4.13e-2)" "unprognostic (3.33e-2)" "prognostic unfavorable (8.04e-5)" "unprognostic (3.43e-2)" "unprognostic (1.82e-1)" "unprognostic (1.77e-1)" "unprognostic (3.59e-2)" "unprognostic (1.05e-1)" "unprognostic (7.19e-3)" "unprognostic (2.21e-1)" "unprognostic (3.66e-2)" "unprognostic (4.73e-2)" "unprognostic (1.10e-2)" 79.7 102.2 62.5 76.2 63.2 65.0 76.7 68.1 74.7 107.0 59.4 87.2 55.1 115.4 44.5 90.7 109.7 49.8 149.2 65.7 71.1 77.9 61.8 76.5 94.0 66.5 65.2 106.7 66.3 65.6 101.1 65.3 68.8 77.1 45.5 71.3 67.6 73.9 242.6 74.8 71.8 74.0 66.3 91.6 69.4 78.4 71.3 79.6 70.9 163.2 84.5 92.6 81.6 68.7 262.5 584.9 396.5 481.7 105.4 118.7 208.4 163.7 283.1 461.8 394.0 439.5 202.2 425.9 119.0 193.4 181.1 188.0 337.3 345.8 200.1 333.7 580.5 311.5 156.4 484.6 256.8 378.7 214.2 166.7 169.3 259.2 369.0 154.8 277.1 338.3 334.0 293.2 182.5 394.1 493.2 467.0 420.5 324.9 375.6 344.8 319.9 388.8 264.0 540.9 440.0 342.4 188.9 193.2 103.4 126.9 146.8 220.6 173.9 269.9 262.5 125.4 398.6 280.0 457.4 429.3 165.7 271.0 289.8 25.0 76.8 37.5 104.0 93.8 129.6 198.9 95.4 111.0 131.5 171.6 105.2 103.3 14.8 162.3 71.9 158.9 97.7 132.5 62.5 63.2 68.1 74.7 65.7 71.1 66.5 65.2 68.8 66.3 71.3 68.7 169.7 3.2 10.3 15.7 112.4 207.0 228.7 444.9 123.5 228.9 71.3 96.8 17.2 40.0 117.3 44.1 106.3 195.6 74.4 45.1 127.2 204.0 5.4 88.9 124.5 167.8 115.2 38.3 9.8 135.2 177.5 101.7 51.5 87.5 54.7 154.2 109.6 22.1 104.1 129.5 15.8 74.5 227.9 27.0 125.7 19.4 104.1 52.9 112.1 15.9 149.4 119.3 57.7 14.6 20.2 125.6 45.6 89.1 117.8 263.0 35.2 87.5 62.8 168.7 92.1 89.7 236.3 66.8 121.8 94.9 158.8 235.2 76.8 200.7 105.0 183.2 PRMT2 "HRMT1L1, MGC111373" ENSG00000160310 "Protein arginine methyltransferase 2" P55345 21 46635595-46665124 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "NK-cells: 451.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018976, HPA029591" Uncertain Supported Nucleoplasm,Cytosol NA NA "Cluster 44: Non-specific - Transcription" "Cluster 70: Brain - Nervous system development" "Cluster 17: WM-115 - Nervous system development" "Cluster 63: NK-cells & T-cells - Immune response" "Nucleoplasm, Cytosol" "HPA018976: AB_1855719, HPA029591: AB_10601250" "unprognostic (1.82e-1)" "unprognostic (2.96e-1)" "unprognostic (8.61e-3)" "unprognostic (1.74e-1)" "unprognostic (1.08e-1)" "unprognostic (1.58e-2)" "unprognostic (1.29e-3)" "unprognostic (1.34e-1)" "unprognostic (2.23e-1)" "unprognostic (6.78e-2)" "unprognostic (4.34e-3)" "unprognostic (1.72e-1)" "unprognostic (4.62e-3)" "unprognostic (8.76e-3)" "unprognostic (2.86e-2)" "unprognostic (1.91e-3)" "unprognostic (2.23e-1)" 37.4 25.4 84.3 42.3 88.4 37.3 39.0 90.1 84.0 43.5 79.6 50.2 27.0 43.2 26.8 55.2 47.0 42.5 56.3 81.4 105.6 36.8 14.4 40.7 57.1 100.7 123.9 82.6 27.4 29.9 27.9 49.3 104.7 38.1 30.4 23.1 38.6 48.3 20.4 51.1 36.7 50.4 91.8 49.8 32.1 16.4 100.0 45.2 36.0 21.8 52.7 44.4 38.2 106.5 75.7 63.4 130.2 48.1 94.0 90.1 31.1 70.6 79.0 77.4 70.2 88.8 60.4 44.5 85.6 126.9 104.3 22.0 59.3 87.4 44.7 110.1 57.2 115.8 55.0 67.4 43.3 34.9 51.7 56.1 85.0 93.4 66.6 87.6 114.5 61.2 74.5 80.4 121.0 84.1 50.3 63.9 69.3 47.5 73.6 63.2 33.2 29.6 61.1 63.3 89.4 56.6 73.8 33.0 135.0 18.5 44.1 35.2 104.8 75.2 50.5 40.4 47.4 21.2 21.0 28.6 70.4 92.4 115.3 256.5 91.9 314.2 261.8 128.4 192.0 93.6 176.3 227.2 131.5 82.7 215.9 248.8 122.3 262.0 135.3 112.7 142.3 223.2 84.3 88.4 90.1 84.0 81.4 105.6 100.7 123.9 104.7 91.8 100.0 106.5 71.5 93.0 36.2 54.5 74.4 46.1 69.8 79.1 66.6 47.7 93.2 103.5 69.5 67.2 61.8 75.4 29.2 64.3 192.9 49.4 90.1 79.1 3.5 51.9 60.2 82.9 35.8 27.3 39.2 52.9 43.5 68.0 48.9 46.1 117.0 132.0 142.8 42.1 107.2 37.0 42.6 32.6 52.9 133.7 102.1 9.0 55.6 109.3 87.2 74.0 182.9 61.1 451.1 69.4 160.6 74.9 40.0 62.1 64.6 94.0 44.0 113.5 71.4 57.7 65.7 53.2 77.2 22.0 39.0 75.0 45.0 69.2 167.1 55.0 38.3 72.9 PRMT5 "HRMT1L5, SKB1, SKB1Hs" ENSG00000100462 "Protein arginine methyltransferase 5" O14744 14 22920525-22929408 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Biological rhythms, Transcription, Transcription regulation" "Chromatin regulator, Methyltransferase, Repressor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Pancreatic endocrine cells: 92.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005525, CAB012459, HPA064708" Approved Supported Nucleoplasm,Cytosol NA NA 45000 "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 52: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 16: Pancreatic endocrine cells - Mixed function" "Nucleoplasm, Cytosol" "CAB012459: , HPA005525: AB_1079679, HPA064708: AB_2685330" "unprognostic (8.34e-2)" "unprognostic (5.14e-3)" "unprognostic (1.19e-2)" "unprognostic (2.19e-1)" "unprognostic (4.56e-3)" "prognostic unfavorable (1.82e-4)" "prognostic unfavorable (4.77e-5)" "unprognostic (3.64e-2)" "unprognostic (6.80e-2)" "unprognostic (1.48e-1)" "prognostic unfavorable (2.61e-4)" "unprognostic (4.69e-2)" "unprognostic (1.99e-3)" "unprognostic (1.21e-1)" "unprognostic (7.04e-2)" "unprognostic (6.28e-2)" "prognostic unfavorable (1.04e-4)" 27.6 31.0 19.9 27.9 21.6 21.7 34.9 21.0 25.9 33.3 24.4 38.4 24.0 36.9 30.6 49.0 44.6 19.4 35.1 20.9 21.8 37.0 28.3 23.2 26.6 20.2 22.2 45.3 32.9 47.3 24.5 30.6 22.0 27.9 35.6 30.8 27.7 33.3 65.8 34.4 23.3 35.5 20.4 26.3 29.2 30.3 21.6 33.1 37.9 42.1 34.3 31.4 33.5 22.8 161.7 169.2 114.2 112.9 62.3 67.7 125.6 104.1 91.6 192.7 156.6 159.2 160.1 171.3 83.2 88.5 108.3 135.8 246.4 212.8 213.9 98.5 119.3 104.5 108.3 256.3 111.4 221.7 85.7 69.3 113.2 143.1 264.8 72.7 91.0 128.5 160.0 91.7 108.5 171.4 151.3 102.9 103.1 160.8 221.8 176.0 140.3 122.7 98.8 110.7 126.0 79.8 125.7 132.3 65.5 94.3 91.3 82.6 70.9 75.1 103.1 103.0 145.9 116.6 246.0 207.2 46.1 109.2 116.0 3.0 31.3 0.4 14.2 31.7 22.9 30.6 19.0 23.0 42.8 27.9 24.4 20.4 7.7 19.8 25.1 25.9 17.6 29.1 19.9 21.6 21.0 25.9 20.9 21.8 20.2 22.2 22.0 20.4 21.6 22.8 8.5 19.2 15.1 5.5 11.4 26.5 26.5 33.8 15.4 10.8 13.9 15.4 1.1 28.6 19.4 7.3 8.4 41.7 8.6 11.1 23.5 32.0 2.3 18.5 21.4 12.3 6.1 24.4 6.1 27.0 33.4 16.7 12.8 12.6 7.0 21.9 10.4 15.1 19.6 16.8 5.8 17.5 20.3 4.4 11.7 3.7 16.4 8.0 26.6 0.0 11.8 18.2 3.1 5.5 4.0 92.8 12.7 21.1 12.4 23.6 7.4 24.6 31.1 11.2 6.6 25.9 19.5 43.1 47.3 20.3 27.8 33.4 8.2 27.5 21.1 17.9 PRMT6 "FLJ10559, HRMT1L6" ENSG00000198890 "Protein arginine methyltransferase 6" Q96LA8 1 107056674-107067636 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Host-virus interaction, Transcription, Transcription regulation" "Chromatin regulator, Methyltransferase, Repressor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in many" 5 "MCF7: 308.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA059424 Approved Supported Nucleoplasm,Nucleoli NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 34: Non-specific - Transcription" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Basic cellular processes" "Nucleoplasm, Nucleoli" "HPA059424: AB_2684012" "unprognostic (5.17e-3)" "unprognostic (1.48e-1)" "unprognostic (1.47e-2)" "prognostic unfavorable (3.05e-4)" "unprognostic (2.68e-1)" "unprognostic (2.55e-1)" "unprognostic (1.36e-3)" "unprognostic (2.13e-2)" "unprognostic (9.72e-2)" "unprognostic (2.53e-2)" "unprognostic (1.42e-1)" "unprognostic (2.63e-1)" "unprognostic (3.15e-2)" "unprognostic (1.03e-1)" "unprognostic (8.34e-2)" "unprognostic (1.01e-1)" "unprognostic (1.73e-3)" 4.9 10.0 5.7 7.2 5.6 4.2 8.0 5.6 5.7 6.1 13.8 7.9 6.1 7.0 8.0 6.8 8.8 6.0 3.9 5.2 6.9 12.0 7.1 4.6 9.6 6.1 6.5 8.6 10.9 9.6 8.4 7.3 5.3 8.5 7.2 6.4 6.5 7.8 1.8 5.6 7.2 5.9 5.5 8.3 7.4 6.6 8.2 10.3 7.0 3.1 8.7 7.9 5.0 6.0 13.6 0.2 25.7 11.3 16.6 18.4 7.0 17.8 13.2 16.9 17.2 17.2 9.2 33.1 24.1 16.5 9.2 18.9 23.9 26.2 13.3 0.0 25.4 20.0 35.6 25.0 16.5 41.6 11.9 17.4 14.2 15.2 15.5 11.4 14.8 18.5 27.1 5.0 15.4 308.1 24.5 14.6 11.1 10.6 24.6 30.8 56.0 12.6 41.3 27.1 47.8 58.3 24.2 34.5 12.1 15.5 24.0 30.7 17.2 12.5 25.5 26.3 26.8 5.4 4.0 5.7 18.4 19.3 10.2 2.1 10.4 1.9 7.9 11.9 9.5 7.4 8.3 7.6 14.1 10.3 11.5 11.9 0.6 17.4 12.0 17.2 9.2 9.3 5.7 5.6 5.6 5.7 5.2 6.9 6.1 6.5 5.3 5.5 8.2 6.0 3.0 0.0 4.4 1.3 6.2 4.5 6.9 9.7 8.6 14.2 8.9 5.0 2.6 5.7 5.8 14.7 0.0 18.3 8.5 3.3 27.4 10.3 1.2 5.2 6.2 4.7 17.5 15.8 1.5 7.4 14.6 6.7 4.6 4.9 1.3 9.4 7.5 2.4 10.0 15.2 2.2 7.4 8.2 7.0 1.6 3.0 8.7 3.8 1.8 3.7 3.9 6.9 3.1 2.0 2.2 4.7 8.5 9.1 2.0 5.1 4.1 18.4 7.4 5.1 13.1 5.9 6.3 9.1 8.1 8.9 6.1 7.1 5.0 13.7 10.3 5.4 PRMT7 "FLJ10640, KIAA1933" ENSG00000132600 "Protein arginine methyltransferase 7" Q9NVM4 16 68310974-68358584 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Differentiation, Transcription, Transcription regulation" "Chromatin regulator, Methyltransferase, Transferase" "Disease variant, Dwarfism, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044241 Supported Enhanced "Nucleoplasm,Nucleoli fibrillar center" No No "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 39: CACO-2 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "Nucleoli fibrillar center" "HPA044241: AB_2678869" "unprognostic (9.33e-2)" "unprognostic (5.33e-2)" "unprognostic (1.52e-1)" "prognostic favorable (2.31e-5)" "unprognostic (2.92e-2)" "unprognostic (1.95e-1)" "unprognostic (4.12e-2)" "unprognostic (1.22e-1)" "unprognostic (3.74e-1)" "unprognostic (1.19e-1)" "unprognostic (4.74e-3)" "unprognostic (3.09e-2)" "unprognostic (7.72e-2)" "unprognostic (1.75e-1)" "unprognostic (9.23e-2)" "unprognostic (3.57e-1)" "unprognostic (1.31e-1)" 9.7 11.9 8.1 6.2 8.3 4.7 10.5 8.4 10.2 9.8 12.0 10.8 3.2 9.4 3.3 7.5 10.7 4.3 13.2 8.3 8.3 8.6 10.2 5.9 9.4 8.9 8.4 12.1 9.7 4.8 11.1 6.3 8.8 10.5 3.0 4.6 10.0 7.0 21.8 9.8 8.8 4.5 8.3 9.7 8.8 9.8 8.4 14.4 8.6 13.5 5.8 9.7 8.3 8.4 18.1 24.7 13.2 36.1 7.1 7.0 50.8 13.8 6.8 19.5 15.6 79.4 16.1 42.4 29.8 14.0 8.4 22.6 20.4 13.8 12.6 12.7 24.5 8.6 30.8 36.8 7.8 24.3 15.8 11.3 4.9 15.2 14.0 9.3 11.8 18.7 28.1 0.8 10.3 28.2 25.8 36.3 25.3 16.5 18.8 43.7 19.3 25.7 10.7 17.7 19.8 13.2 53.5 16.2 15.7 11.9 25.2 22.2 16.0 14.7 12.9 19.9 17.6 9.6 22.5 41.6 17.1 23.4 16.8 12.3 8.2 7.1 17.4 10.6 20.2 10.9 11.6 14.9 11.8 12.8 16.7 15.4 0.8 21.4 9.5 32.9 14.7 14.3 8.1 8.3 8.4 10.2 8.3 8.3 8.9 8.4 8.8 8.3 8.4 8.4 7.1 19.2 10.6 16.6 12.1 6.9 8.9 12.8 9.1 21.2 10.8 8.8 13.3 8.6 10.0 9.2 54.2 25.4 12.6 28.3 5.9 12.3 4.4 12.9 8.7 7.6 13.2 7.8 25.0 16.1 8.4 10.5 23.4 5.9 7.0 24.9 6.8 8.4 12.2 30.3 25.9 32.4 10.2 7.7 20.6 4.3 11.8 6.2 8.8 12.2 9.1 9.7 13.4 18.6 20.4 23.6 29.8 13.2 6.9 6.7 24.7 7.7 14.5 18.2 13.1 9.9 8.6 6.9 19.3 6.1 6.0 11.6 16.5 10.0 24.1 12.7 PRMT8 "HRMT1L3, HRMT1L4" ENSG00000111218 "Protein arginine methyltransferase 8" Q9NR22 12 3381349-3593973 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "brain: 7.8;retina: 3.9;testis: 2.5" "Cell type enhanced" "Detected in some" "Bipolar cells: 21.7;Cone photoreceptor cells: 16.7;Early spermatids: 22.8;Excitatory neurons: 60.5;Inhibitory neurons: 63.8;Late spermatids: 15.4" "Cancer enhanced" "Detected in single" "thyroid cancer: 1.1" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 10 "hTERT-HME1: 48.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039747, HPA069769" Enhanced NA NA "Cluster 58: Brain - Synaptic function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA039747: AB_2732482, HPA069769: AB_2686193" "unprognostic (3.09e-1)" "unprognostic (9.47e-2)" "unprognostic (5.59e-1)" "unprognostic (3.34e-3)" "unprognostic (4.80e-3)" "unprognostic (9.41e-2)" "unprognostic (3.41e-5)" "unprognostic (5.99e-1)" "unprognostic (1.93e-1)" "unprognostic (1.50e-2)" "unprognostic (7.06e-2)" "unprognostic (2.07e-1)" "unprognostic (1.13e-1)" "unprognostic (2.64e-1)" "unprognostic (6.02e-2)" "unprognostic (5.49e-2)" 0.0 0.0 3.2 0.0 7.8 0.0 0.0 3.8 7.2 0.1 0.1 0.0 0.0 0.0 0.0 0.0 1.2 0.0 1.0 5.4 1.5 0.6 0.0 0.8 0.0 2.1 3.0 0.0 0.6 0.0 0.1 0.0 0.7 0.0 0.0 3.9 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 2.5 4.0 1.1 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.0 3.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.6 0.0 48.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.2 7.8 3.8 7.2 5.4 1.5 2.1 3.0 0.7 0.3 4.0 3.6 0.0 6.4 1.7 1.6 0.1 0.0 0.0 0.0 0.0 21.7 0.1 0.0 1.3 0.0 5.0 0.0 16.7 0.0 0.0 0.1 0.0 0.0 22.8 2.2 0.1 0.3 0.0 0.0 60.5 0.0 0.0 0.4 0.0 0.0 0.0 1.2 0.0 0.0 0.0 5.0 63.8 0.0 4.1 0.0 4.2 15.4 0.6 0.4 0.0 1.0 0.0 0.7 0.0 3.0 1.0 0.0 0.0 0.4 0.0 0.1 0.0 0.8 7.5 1.6 0.0 0.0 0.2 3.5 1.5 0.0 0.0 0.0 0.2 0.0 0.1 0.2 PRMT9 "FLJ46629, PRMT10" ENSG00000164169 "Protein arginine methyltransferase 9" Q6P2P2 4 147637785-147684163 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 112.6;Rod photoreceptor cells: 81.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036844, HPA042537" Uncertain Approved Nucleoplasm,Microtubules,Cytosol NA NA "Cluster 6: Non-specific - Transcription" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 7: Non-specific - Mitochondria" Microtubules "Nucleoplasm, Cytosol" "HPA036844: AB_10672341, HPA042537: AB_2678043" "unprognostic (2.17e-1)" "unprognostic (1.46e-2)" "unprognostic (4.65e-3)" "unprognostic (2.35e-1)" "unprognostic (8.46e-3)" "unprognostic (1.10e-1)" "unprognostic (1.35e-1)" "unprognostic (1.55e-2)" "unprognostic (4.14e-2)" "unprognostic (7.29e-2)" "unprognostic (2.11e-2)" "unprognostic (2.33e-1)" "prognostic favorable (3.58e-7)" "unprognostic (1.72e-1)" "unprognostic (4.52e-2)" "unprognostic (1.54e-2)" "unprognostic (1.30e-2)" 3.2 9.9 1.4 2.8 1.8 8.5 4.1 3.1 2.4 2.8 1.8 2.3 1.4 4.6 3.1 2.9 3.3 3.0 2.8 2.0 1.8 4.3 3.4 3.2 3.5 1.4 1.6 11.3 3.3 6.1 3.6 3.0 1.5 3.4 2.6 5.2 2.7 3.3 3.3 2.8 1.8 2.7 1.6 2.8 3.1 7.1 1.7 4.5 5.7 2.5 3.0 2.5 2.3 1.6 2.8 1.8 4.3 3.3 3.3 5.6 3.8 3.1 4.9 4.6 4.8 1.4 3.1 9.8 1.3 2.7 2.3 1.9 5.1 2.6 6.3 3.5 3.0 5.4 3.6 2.3 2.5 8.0 2.8 3.9 2.7 2.8 2.5 3.7 3.9 4.8 5.4 5.5 3.9 1.6 6.8 3.1 2.2 2.7 3.2 4.5 3.7 3.6 3.7 2.2 2.7 4.1 4.9 3.8 2.5 2.8 1.6 1.7 3.3 2.9 2.4 3.3 3.4 6.2 5.3 6.1 3.3 4.8 2.2 6.1 4.2 8.6 4.7 4.7 4.6 7.4 5.7 5.8 3.0 7.2 7.1 6.2 2.8 4.3 3.5 4.4 5.5 2.1 1.4 1.8 3.1 2.4 2.0 1.8 1.4 1.6 1.5 1.6 1.7 1.6 8.7 0.0 5.3 9.8 40.4 0.0 4.2 0.0 26.7 56.5 11.7 21.8 5.9 7.2 0.6 35.0 112.6 14.5 51.6 6.2 5.9 7.0 73.1 9.2 9.5 8.4 17.4 10.3 29.8 6.5 14.8 12.9 11.2 13.0 33.7 15.6 12.8 6.9 17.2 50.5 29.8 7.2 0.0 36.5 0.0 13.4 18.0 63.7 0.0 17.8 10.9 48.1 16.5 20.6 16.3 7.4 6.2 17.0 18.4 4.1 7.4 5.5 1.5 81.1 13.1 6.2 18.5 36.5 19.6 4.3 0.0 15.2 61.2 18.5 6.3 2.0 PRPF19 "hPSO4, NMP200, PRP19, PSO4, SNEV, UBOX4" ENSG00000110107 "Pre-mRNA processing factor 19" Q9UMS4 11 60890547-60906585 "Enzymes, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, mRNA processing, mRNA splicing, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB012448, HPA038051, HPA059070" Supported Enhanced "Nuclear speckles" NA NA 71000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 12: Non-specific - Cell cycle regulation" "Nuclear speckles" "CAB012448: AB_2170868, HPA038051: AB_2675807, HPA059070: AB_2683896" "unprognostic (5.73e-2)" "unprognostic (2.11e-1)" "unprognostic (2.49e-1)" "unprognostic (2.68e-1)" "unprognostic (4.51e-2)" "unprognostic (1.18e-2)" "prognostic unfavorable (4.11e-8)" "unprognostic (1.03e-1)" "unprognostic (2.13e-1)" "unprognostic (9.37e-3)" "unprognostic (9.53e-2)" "unprognostic (1.54e-1)" "unprognostic (6.70e-2)" "unprognostic (9.62e-2)" "unprognostic (7.12e-2)" "unprognostic (9.04e-2)" "unprognostic (3.41e-3)" 46.1 70.6 89.8 49.8 87.9 67.0 48.8 73.7 100.2 57.4 60.2 54.5 42.9 55.4 34.2 81.7 57.3 29.4 47.9 91.3 94.1 50.4 77.2 34.6 64.1 92.0 80.7 66.6 69.4 79.8 79.3 42.9 92.9 62.1 51.8 46.1 56.5 48.2 75.2 80.3 49.5 47.9 75.6 54.3 54.3 30.5 81.1 78.5 43.4 38.9 73.7 58.7 55.9 84.5 197.5 147.0 161.8 116.2 92.7 80.8 155.6 102.4 137.5 200.2 149.0 162.7 141.1 280.5 145.2 98.2 120.2 179.0 229.2 184.6 153.4 207.0 153.4 232.4 111.3 184.9 134.2 308.6 161.1 86.3 137.0 154.4 171.9 58.7 158.7 167.4 248.2 155.3 99.5 270.6 328.9 249.5 292.6 150.5 197.7 285.8 165.5 227.5 101.7 127.5 142.3 172.9 126.6 208.3 178.0 73.1 225.8 170.2 101.9 89.6 147.2 161.8 171.2 147.2 223.3 287.9 111.6 208.6 138.6 4.2 7.8 2.0 2.4 3.8 1.7 0.9 1.8 1.7 3.6 2.4 2.2 2.0 0.5 1.8 2.3 3.9 1.7 1.0 89.8 87.9 73.7 100.2 91.3 94.1 92.0 80.7 92.9 75.6 81.1 84.5 15.8 19.2 23.7 10.1 26.7 42.1 35.2 40.2 33.0 32.0 24.6 19.4 17.6 20.0 28.6 27.6 10.4 94.7 16.2 20.4 27.4 48.5 21.6 21.4 19.7 27.3 39.0 45.2 19.8 51.6 90.2 24.9 23.4 28.4 22.8 25.4 20.0 46.1 46.3 62.2 22.2 40.0 32.6 23.0 21.6 3.6 37.0 19.3 26.6 11.2 41.2 25.4 21.6 10.1 11.8 33.4 27.7 38.7 31.9 40.4 27.8 27.9 17.8 25.3 46.0 22.4 22.6 25.2 38.0 37.4 41.6 40.6 24.8 24.8 55.1 26.3 PRPF4B "KIAA0536, PR4H, Prp4" ENSG00000112739 "Pre-mRNA processing factor 4B" Q13523 6 4021267-4064983 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "mRNA processing, mRNA splicing" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA020638 Approved Supported "Nuclear speckles" NA NA "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 20: HeLa - Mitochondria" "Cluster 52: Non-specific - Transcription" "Nuclear speckles" "HPA020638: AB_1855774" "unprognostic (1.03e-1)" "unprognostic (2.66e-1)" "unprognostic (4.95e-2)" "unprognostic (2.20e-1)" "unprognostic (3.59e-3)" "unprognostic (1.21e-2)" "prognostic unfavorable (2.27e-4)" "unprognostic (8.68e-3)" "unprognostic (3.41e-2)" "unprognostic (4.45e-3)" "unprognostic (2.17e-1)" "unprognostic (1.07e-1)" "unprognostic (9.50e-3)" "unprognostic (8.90e-2)" "unprognostic (2.34e-1)" "unprognostic (7.63e-3)" "prognostic favorable (6.82e-5)" 9.1 7.2 4.8 11.3 5.4 27.3 8.1 7.5 6.7 5.8 5.2 8.6 10.2 9.9 10.1 8.4 4.4 6.1 5.0 4.7 5.1 4.2 4.3 6.8 14.2 5.4 5.5 8.4 6.8 4.2 3.3 7.6 5.3 6.3 8.6 15.9 8.4 5.5 16.3 13.3 9.0 5.6 4.9 11.2 8.1 3.8 5.5 8.8 6.5 4.5 10.0 6.7 7.0 6.9 6.0 3.9 14.4 12.1 8.3 7.3 12.3 7.7 3.4 4.7 5.2 6.9 7.1 8.1 5.7 5.1 4.8 12.8 10.1 6.8 7.1 4.4 11.1 6.7 19.1 11.5 3.6 11.2 10.6 5.7 6.9 5.4 6.6 11.0 5.1 6.5 11.6 3.1 7.4 2.7 7.2 26.3 6.0 3.8 4.3 9.9 6.1 11.2 8.4 10.2 7.9 7.3 4.7 3.9 5.5 16.9 9.6 7.9 7.3 11.2 6.5 4.3 8.2 7.5 7.9 6.9 3.2 7.6 7.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.8 5.4 7.5 6.7 4.7 5.1 5.4 5.5 5.3 4.9 5.5 6.9 122.4 109.0 103.2 35.6 110.5 83.5 64.0 43.1 69.4 88.6 80.4 49.5 79.1 61.5 75.1 97.5 89.6 61.8 151.3 94.9 72.4 64.4 15.6 115.9 143.5 85.8 75.3 79.1 42.8 56.8 49.9 78.7 88.2 113.4 90.5 96.2 61.1 85.8 41.1 106.0 49.8 88.8 50.8 71.6 49.4 20.6 98.8 71.4 35.6 49.6 97.4 81.2 118.4 50.8 68.1 62.8 61.5 89.1 101.9 62.8 55.5 89.5 71.7 184.0 59.2 105.3 85.8 66.1 76.5 66.7 91.4 63.6 106.2 93.1 87.7 65.2 PRPS1 "CMTX5, DFN2, DFNX1" ENSG00000147224 "Phosphoribosyl pyrophosphate synthetase 1" P60891 X 107628428-107651993 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Nucleotide biosynthesis" "Kinase, Transferase" "Charcot-Marie-Tooth disease, Deafness, Disease variant, Gout, Mental retardation, Neurodegeneration, Neuropathy, Non-syndromic deafness, Retinitis pigmentosa" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA043760, HPA051269" Uncertain Approved Vesicles NA NA 320000 "Cluster 13: T-cells - Unknown function" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 24: Non-specific - Transcription regulation" Vesicles "HPA043760: AB_2678656, HPA051269: " "unprognostic (4.47e-2)" "unprognostic (6.18e-2)" "unprognostic (2.57e-2)" "unprognostic (4.19e-3)" "unprognostic (2.30e-3)" "unprognostic (2.56e-3)" "unprognostic (3.24e-2)" "unprognostic (1.14e-1)" "unprognostic (1.46e-1)" "unprognostic (9.73e-2)" "unprognostic (1.91e-2)" "unprognostic (4.11e-2)" "unprognostic (2.85e-2)" "unprognostic (4.57e-2)" "unprognostic (1.29e-1)" "unprognostic (1.25e-2)" "unprognostic (5.25e-2)" 22.9 28.0 33.7 30.2 35.0 58.0 21.0 32.4 36.4 20.0 59.3 19.0 11.0 23.7 14.8 13.7 25.9 13.9 22.2 33.7 39.6 27.6 51.5 21.5 42.7 35.4 39.1 30.2 21.7 27.2 23.2 14.6 37.6 21.3 17.9 30.2 16.3 17.4 49.1 12.3 16.7 29.5 34.2 26.2 15.5 13.4 35.2 52.0 44.1 37.9 45.7 23.6 15.2 34.4 93.5 128.9 56.4 69.9 32.7 26.5 18.6 253.2 55.8 146.0 122.6 55.5 36.6 156.9 111.7 94.9 104.1 36.6 176.0 53.8 148.3 79.9 150.9 84.2 140.0 100.3 28.8 153.1 55.6 28.2 30.6 90.2 56.2 96.7 52.3 108.2 137.4 183.5 69.0 51.0 101.2 113.6 213.5 77.2 141.4 117.6 96.3 125.4 60.7 54.2 96.2 52.5 131.5 77.6 57.3 106.4 36.0 61.7 31.2 93.2 45.0 108.3 109.1 61.8 115.1 172.7 50.1 163.6 61.6 8.8 8.9 22.6 26.0 14.3 30.8 29.3 31.7 32.2 11.4 31.0 36.1 30.7 4.7 28.5 15.7 16.3 35.5 21.1 33.7 35.0 32.4 36.4 33.7 39.6 35.4 39.1 37.6 34.2 35.2 34.4 21.0 6.4 10.0 4.6 44.2 31.1 18.4 13.2 12.0 28.4 8.3 9.4 12.1 15.7 12.6 16.5 4.2 8.8 29.3 3.0 25.4 18.3 1.2 11.5 13.3 18.1 16.2 52.2 4.8 20.2 11.5 22.2 10.2 5.7 26.6 13.2 14.6 57.5 35.3 15.2 10.0 6.5 6.1 18.6 34.8 3.9 14.0 16.8 26.6 6.5 24.9 20.0 27.8 3.5 4.8 19.1 3.7 17.0 35.7 16.2 1.5 29.4 27.1 14.1 0.0 18.1 30.7 3.6 10.9 10.8 22.3 1.8 45.0 19.7 8.0 9.7 PRPS1L1 "PRPS3, PRPSL" ENSG00000229937 "Phosphoribosyl pyrophosphate synthetase 1 like 1" P21108 7 18026770-18027846 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Nucleotide biosynthesis" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 315 "testis: 31.5" "Group enriched" "Detected in some" 7 "Early spermatids: 71.0;Spermatocytes: 129.6" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA051269 Uncertain Vesicles NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 66: Spermatocytes - Spermatogenesis" Vesicles "HPA051269: " "unprognostic (2.39e-2)" "unprognostic (3.18e-2)" "unprognostic (1.11e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 31.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 71.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.3 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.1 0.0 0.0 0.0 0.0 6.6 0.0 1.1 129.6 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 PRPS2 ENSG00000101911 "Phosphoribosyl pyrophosphate synthetase 2" P11908 X 12791355-12824222 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Nucleotide biosynthesis" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "ovary: 147.8;parathyroid gland: 182.0" "Group enriched" "Detected in many" 7 "Leydig cells: 1431.5;Peritubular cells: 1995.0;Sertoli cells: 624.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA051269, HPA067599, CAB070417" Enhanced Approved "Nuclear speckles,Vesicles" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 52: Non-specific - Transcription" Vesicles "Nuclear speckles" "CAB070417: AB_11152035, HPA051269: , HPA067599: AB_2685869" "unprognostic (7.50e-2)" "prognostic favorable (1.90e-4)" "unprognostic (2.09e-3)" "unprognostic (1.03e-1)" "unprognostic (1.16e-2)" "unprognostic (1.10e-1)" "unprognostic (7.63e-2)" "unprognostic (4.75e-2)" "unprognostic (6.98e-2)" "unprognostic (2.64e-3)" "unprognostic (4.44e-3)" "unprognostic (1.81e-1)" "unprognostic (7.83e-2)" "unprognostic (2.20e-1)" "unprognostic (1.50e-1)" "unprognostic (1.35e-1)" "unprognostic (2.04e-1)" 11.0 46.0 6.3 24.5 7.3 24.2 19.7 1.9 12.0 54.5 2.5 30.3 14.0 32.8 26.5 16.1 29.7 28.1 5.4 6.9 2.9 28.0 26.1 13.1 36.8 3.0 6.5 147.8 62.8 182.0 3.4 6.1 2.2 21.9 31.3 1.3 27.9 84.0 2.1 21.9 15.8 24.3 4.4 15.6 32.5 131.1 8.8 44.6 18.1 4.2 31.5 22.5 21.2 6.4 114.2 63.7 22.1 40.3 26.7 31.8 14.6 54.4 26.8 53.1 51.1 46.3 78.7 34.9 24.2 23.5 45.3 79.9 43.1 53.7 61.5 89.7 108.0 41.7 49.6 43.3 24.7 77.3 38.9 30.5 35.0 39.1 51.7 26.9 22.1 86.8 30.4 39.8 45.2 68.5 117.6 34.7 49.9 81.0 107.3 61.5 102.7 79.5 33.0 81.7 46.1 33.6 64.9 2.1 38.9 30.2 58.8 32.4 24.9 41.8 32.0 162.5 55.5 103.6 41.3 76.8 44.4 39.4 67.4 25.9 20.1 9.4 17.2 19.4 19.9 27.8 25.0 16.4 28.2 30.6 31.7 23.0 8.0 24.3 12.3 19.9 22.6 28.2 6.3 7.3 1.9 12.0 6.9 2.9 3.0 6.5 2.2 4.4 8.8 6.4 12.2 3.2 8.7 0.7 25.4 64.0 48.5 16.2 41.5 0.6 53.1 15.9 2.0 11.5 12.4 55.2 0.0 1.1 18.5 21.1 72.4 19.3 12.1 24.7 62.5 14.5 21.8 28.4 14.8 39.2 7.3 25.8 31.1 26.4 27.9 16.2 10.4 13.7 24.4 0.0 6.3 27.9 8.2 21.4 44.3 65.8 1431.5 20.7 40.9 3.7 18.2 1.2 18.6 3.5 5.1 24.6 17.4 1995.0 30.7 52.2 6.0 10.4 20.3 0.2 624.5 9.4 19.2 10.3 8.1 29.2 43.8 0.4 27.2 179.2 50.2 36.9 PSAT1 PSA ENSG00000135069 "Phosphoserine aminotransferase 1" Q9Y617 9 78297125-78330093 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Amino-acid biosynthesis, Serine biosynthesis" "Aminotransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 175.0;liver: 267.9" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 115.5;Glandular and luminal cells: 145.9;Hepatocytes: 161.7;Proximal tubular cells: 304.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "T-reg: 15.1" "Lineage enriched" "Detected in many" 5 "T-cells: 15.1" "Cell line enhanced" "Detected in many" "hTCEpi: 1170.1;SK-MEL-30: 752.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB014882, CAB040567, HPA042924" Enhanced Enhanced Cytosol NA NA 2400000 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 22: Non-specific - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Cytosol "CAB014882: , CAB040567: , HPA042924: AB_2678223" "unprognostic (8.26e-3)" "unprognostic (4.69e-2)" "unprognostic (1.46e-1)" "prognostic unfavorable (5.62e-5)" "unprognostic (4.05e-3)" "unprognostic (1.41e-1)" "unprognostic (2.21e-3)" "unprognostic (1.86e-1)" "unprognostic (9.85e-2)" "unprognostic (2.25e-2)" "unprognostic (4.53e-2)" "unprognostic (1.07e-1)" "prognostic unfavorable (6.00e-7)" "unprognostic (3.87e-3)" "unprognostic (1.21e-1)" "unprognostic (8.07e-3)" "unprognostic (1.71e-1)" 7.8 65.8 123.3 7.3 124.6 2.0 5.1 130.5 175.0 5.1 92.8 5.9 5.4 4.3 61.6 33.2 34.7 1.7 2.7 122.4 126.5 136.7 267.9 5.1 9.3 130.2 122.4 5.6 129.1 9.7 7.6 3.0 129.9 10.0 5.5 6.2 19.2 4.0 0.6 57.2 4.5 3.3 133.6 6.0 19.4 10.4 120.3 30.0 30.3 0.5 12.4 7.3 11.2 161.6 222.8 146.0 121.1 215.6 35.1 41.2 284.7 184.3 130.4 91.8 170.6 38.2 41.9 143.2 79.8 416.9 82.9 215.3 209.1 203.6 136.4 141.2 73.9 49.2 60.8 293.3 322.0 277.6 84.6 131.1 1170.1 122.0 322.9 22.6 85.0 548.3 53.8 358.2 77.1 83.2 95.8 44.3 278.2 415.1 158.4 46.5 78.6 173.4 126.6 50.9 54.9 127.0 51.1 87.7 752.3 75.9 42.0 344.1 19.9 23.2 73.5 85.9 151.5 242.0 242.7 0.8 268.9 215.6 112.1 0.0 0.0 0.0 5.2 0.0 5.9 3.1 5.0 7.0 0.3 1.3 8.1 7.5 0.3 0.0 0.1 0.0 15.1 3.3 123.3 124.6 130.5 175.0 122.4 126.5 130.2 122.4 129.9 133.6 120.3 161.6 0.4 0.0 0.0 70.2 11.0 41.9 8.8 18.9 115.5 0.9 1.8 3.9 0.6 1.5 4.7 11.0 0.0 32.0 2.2 2.0 62.6 11.5 1.7 77.7 10.3 3.7 3.6 29.9 7.3 48.4 13.7 4.2 6.6 145.9 0.0 0.5 3.6 161.7 5.3 5.0 6.0 4.8 18.3 4.4 2.9 3.8 5.0 3.4 19.6 5.6 3.8 26.7 0.0 48.2 78.8 22.7 0.1 1.9 29.1 16.0 0.3 304.1 3.8 1.1 0.0 33.5 14.3 1.6 3.7 35.5 50.7 9.3 8.6 68.2 4.2 11.8 PSKH1 ENSG00000159792 "Protein serine kinase H1" P11801 16 67893254-67929676 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA053927, HPA062763" Approved Supported "Nuclear speckles,Cytosol" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 29: Non-specific - Vesicular transport" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 40: Granulosa cells - Unknown function" "Nuclear speckles, Cytosol" "HPA053927: AB_2682312, HPA062763: " "unprognostic (2.57e-2)" "unprognostic (8.91e-3)" "unprognostic (1.88e-1)" "unprognostic (5.79e-2)" "unprognostic (3.26e-1)" "unprognostic (3.89e-1)" "unprognostic (1.64e-1)" "unprognostic (1.29e-2)" "unprognostic (3.03e-1)" "unprognostic (1.66e-2)" "unprognostic (9.85e-3)" "unprognostic (8.32e-2)" "prognostic favorable (4.28e-10)" "unprognostic (1.46e-1)" "unprognostic (1.99e-1)" "unprognostic (4.15e-2)" "unprognostic (3.90e-3)" 14.3 18.6 12.8 9.6 14.5 5.2 14.0 12.2 13.5 13.5 19.5 18.2 13.7 19.3 10.0 16.9 18.7 10.1 17.6 11.2 11.5 20.5 16.5 12.7 10.6 15.0 14.9 19.4 26.3 32.9 13.2 7.6 13.4 15.1 10.8 4.0 18.1 12.7 15.3 13.8 15.7 15.7 13.2 12.8 21.4 21.8 13.6 12.0 15.0 13.5 8.5 16.5 9.5 14.9 13.0 22.7 25.2 28.1 38.4 19.3 16.3 15.2 23.0 15.8 14.0 17.2 18.2 12.2 22.7 25.7 12.7 19.2 14.7 15.6 5.3 4.8 16.4 13.9 16.8 22.0 26.3 13.4 8.0 35.7 26.7 18.8 19.6 21.3 23.3 22.5 21.6 5.1 16.7 28.7 18.3 8.6 24.2 14.0 13.9 27.7 9.7 25.3 18.6 16.0 21.8 26.0 47.3 12.8 15.8 9.9 23.5 23.9 20.8 17.7 6.2 15.0 7.7 15.3 8.7 26.2 21.4 8.8 19.9 0.0 2.0 1.9 2.0 2.2 1.4 1.5 1.5 2.0 2.1 1.2 1.2 1.7 1.0 2.1 1.5 1.5 0.8 1.7 12.8 14.5 12.2 13.5 11.2 11.5 15.0 14.9 13.4 13.2 13.6 14.9 5.5 0.0 3.6 4.6 2.9 1.1 3.1 5.2 2.2 11.1 5.3 4.6 2.3 7.2 3.8 5.5 6.2 6.2 3.0 11.5 11.7 6.0 14.4 5.8 6.5 5.2 10.8 3.0 4.6 7.4 4.8 5.4 5.1 4.8 6.3 13.0 5.3 10.3 4.8 6.7 6.1 6.2 10.2 6.3 1.6 22.1 4.7 2.9 5.4 3.7 4.8 11.0 3.1 5.5 9.2 7.6 4.5 7.9 3.0 3.6 10.0 8.1 4.9 6.9 13.1 6.3 6.1 6.7 6.1 5.4 1.6 5.9 3.8 10.7 7.4 2.2 PSKH2 ENSG00000147613 "Protein serine kinase H2" Q96QS6 8 86047109-86088621 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 10 "retina: 2.4" "Cell type enhanced" "Detected in single" "Rod photoreceptor cells: 2.1" "Cancer enriched" "Detected in single" 5 "testis cancer: 0.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 12 "HEL: 9.4" "HPA015095, HPA056839" Approved Approved "Nucleoplasm,Nuclear bodies,Cytosol" NA NA "Cluster 77: Retina - Visual perception" "Cluster 36: HEL - Hemostasis" "Cluster 46: Photoreceptor cells - Phototransduction" Nucleoplasm "Nuclear bodies, Cytosol" "HPA015095: AB_1855815, HPA056839: " "unprognostic (1.77e-2)" 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 PSTK "C10orf89, MGC35392" ENSG00000179988 "Phosphoseryl-tRNA kinase" Q8IV42 10 122954381-122997513 "Enzymes, Predicted intracellular proteins" "Protein biosynthesis" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Early spermatids: 31.3;Spermatocytes: 37.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037780, HPA037781" Approved Approved "Nucleoli,Nuclear bodies,Actin filaments" No No "Cluster 24: B-cells - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 30: Epithelial cell lines - Translation" "Cluster 66: Spermatocytes - Spermatogenesis" "Actin filaments" "Nucleoli, Nuclear bodies" "HPA037780: AB_2675662, HPA037781: AB_10670530" "unprognostic (8.95e-3)" "unprognostic (5.51e-3)" "unprognostic (1.37e-1)" "unprognostic (7.39e-4)" "unprognostic (5.21e-2)" "unprognostic (4.08e-3)" "unprognostic (1.60e-2)" "unprognostic (5.92e-4)" "unprognostic (3.55e-2)" "unprognostic (1.16e-1)" "unprognostic (6.22e-3)" "unprognostic (7.10e-3)" "unprognostic (2.39e-1)" "unprognostic (4.50e-2)" "unprognostic (4.92e-2)" "unprognostic (3.02e-2)" "unprognostic (5.55e-4)" 0.9 2.2 1.3 0.6 1.5 6.1 2.9 1.5 2.2 1.9 0.3 1.6 1.9 1.9 3.5 1.5 1.9 0.7 1.7 1.5 1.6 2.0 4.1 1.0 0.9 1.6 1.5 1.3 2.1 1.1 2.6 1.3 2.5 2.0 1.5 0.5 1.9 1.1 3.5 1.6 1.0 1.9 1.3 1.1 1.3 3.2 1.4 1.8 2.4 0.9 1.2 1.3 1.3 2.8 4.1 3.4 1.7 0.8 1.6 3.2 2.1 2.0 3.5 3.0 3.7 4.6 3.4 4.4 3.9 2.5 2.0 2.3 0.7 3.1 3.4 2.4 8.7 2.7 1.2 4.0 4.3 6.7 3.6 3.3 5.2 2.9 5.2 2.7 2.3 3.9 4.3 6.0 4.3 6.6 2.0 3.9 3.3 1.6 4.3 4.5 3.0 4.4 4.3 2.6 1.6 2.1 3.9 3.8 5.3 1.4 1.8 0.4 3.1 2.8 2.6 1.2 4.5 2.6 1.6 5.8 2.4 4.3 0.9 0.0 5.0 6.0 7.4 3.1 8.8 6.2 5.7 7.0 6.7 5.9 7.5 7.7 0.6 6.8 3.6 6.7 3.8 5.3 1.3 1.5 1.5 2.2 1.5 1.6 1.6 1.5 2.5 1.3 1.4 2.8 3.0 9.6 7.3 14.4 4.6 4.5 5.0 11.0 5.2 8.3 7.1 11.7 5.9 10.0 7.5 5.5 8.4 7.7 8.0 1.6 9.8 4.6 31.3 5.7 5.2 3.2 4.2 3.4 18.8 6.3 3.1 6.0 1.5 11.6 2.5 8.1 3.6 6.3 4.8 5.0 20.3 2.6 14.2 2.1 4.3 5.4 5.3 3.0 5.4 4.7 6.1 8.8 5.2 12.5 29.4 3.7 3.8 5.7 3.3 3.5 3.0 7.7 8.3 11.4 0.0 5.6 8.6 37.5 20.6 5.5 4.7 9.6 6.9 10.8 4.3 3.5 PTDSS1 "KIAA0024, PSS1, PSSA" ENSG00000156471 "Phosphatidylserine synthase 1" P48651 8 96261902-96336995 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" Transferase "Disease variant, Dwarfism, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in many" "basophil: 10.5" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016852 Uncertain Approved "Nucleoplasm,Endoplasmic reticulum" NA NA "Cluster 34: Basophils - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 57: B-cells - Immune response" "Endoplasmic reticulum" Nucleoplasm "HPA016852: AB_1855878" "unprognostic (1.44e-1)" "unprognostic (1.71e-1)" "unprognostic (1.08e-1)" "unprognostic (7.89e-3)" "unprognostic (7.48e-2)" "unprognostic (5.68e-3)" "prognostic unfavorable (1.08e-5)" "prognostic unfavorable (9.83e-4)" "unprognostic (2.79e-1)" "unprognostic (1.71e-2)" "unprognostic (2.36e-2)" "unprognostic (1.19e-1)" "unprognostic (2.29e-3)" "unprognostic (4.78e-2)" "unprognostic (1.79e-1)" "unprognostic (4.08e-2)" "unprognostic (3.55e-2)" 1.6 2.2 1.6 3.4 2.0 4.9 3.1 1.2 2.6 3.5 0.8 3.4 4.1 2.1 2.8 3.7 2.5 3.1 7.2 1.8 1.0 3.7 4.6 2.6 5.6 0.5 0.6 3.6 2.7 8.0 0.6 4.6 1.3 1.9 2.9 0.9 2.0 3.5 2.9 3.2 3.2 3.6 0.2 2.6 1.4 1.9 2.0 3.6 4.5 3.0 5.2 2.6 1.1 1.4 14.9 11.6 2.0 5.5 4.2 8.5 3.4 10.6 15.5 10.6 7.5 4.6 4.2 24.9 9.5 10.5 2.1 6.0 14.1 11.1 16.1 12.5 10.3 24.5 19.8 2.5 4.3 17.8 8.1 7.2 10.9 14.4 10.2 2.7 7.0 7.6 12.5 12.3 9.7 4.4 14.0 3.0 3.1 5.1 11.1 10.9 10.1 18.8 5.7 12.5 8.6 3.5 3.9 3.4 1.4 2.3 8.2 6.3 11.8 9.1 5.5 6.3 12.3 2.5 13.3 11.8 5.7 19.3 7.5 10.5 2.6 1.5 1.7 1.6 2.5 1.7 2.8 2.2 4.0 2.2 2.5 1.8 0.9 3.2 1.7 1.2 1.7 6.7 1.6 2.0 1.2 2.6 1.8 1.0 0.5 0.6 1.3 0.2 2.0 1.4 12.4 19.2 9.1 8.8 50.5 31.6 18.9 22.6 42.7 10.2 22.9 18.4 94.5 14.3 15.6 11.0 10.4 78.4 23.6 11.9 1.9 20.5 60.1 6.6 9.1 22.9 5.4 38.3 29.3 44.9 54.1 18.0 14.8 9.3 32.4 17.6 34.2 32.1 45.9 5.0 29.2 17.1 10.2 45.3 31.5 52.2 23.3 36.0 19.6 15.9 39.3 4.7 29.9 21.1 8.7 23.9 11.9 25.9 45.5 21.4 16.6 19.0 5.2 4.7 0.0 13.8 15.8 12.1 18.8 33.1 33.5 80.9 34.3 14.6 34.8 16.3 PTDSS2 PSS2 ENSG00000174915 "Phosphatidylserine synthase 2" Q9BVG9 11 448268-491399 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 5 "Early spermatids: 144.6;Late spermatids: 347.6;Spermatocytes: 98.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in all" "HEK 293: 67.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038928, HPA038929" Approved NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 71: Testis - DNA repair" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 25: Spermatids - Spermatogenesis" "HPA038928: AB_10672832, HPA038929: AB_2676274" "unprognostic (3.41e-1)" "unprognostic (2.52e-1)" "unprognostic (2.07e-1)" "unprognostic (5.75e-3)" "unprognostic (3.19e-2)" "unprognostic (1.44e-1)" "prognostic unfavorable (5.12e-9)" "unprognostic (6.18e-2)" "unprognostic (1.09e-1)" "unprognostic (1.89e-2)" "unprognostic (1.41e-3)" "unprognostic (6.41e-2)" "unprognostic (1.11e-2)" "unprognostic (3.39e-2)" "unprognostic (2.48e-1)" "unprognostic (2.25e-1)" "unprognostic (1.09e-1)" 13.8 21.3 6.2 2.2 9.6 2.2 12.5 8.6 8.6 16.3 8.4 15.4 1.5 15.4 3.7 12.0 14.7 3.9 25.2 6.3 6.1 21.0 13.5 12.8 2.3 10.6 9.1 21.9 18.9 13.6 13.7 5.8 8.1 17.0 2.2 3.1 11.4 5.2 17.7 11.9 10.4 4.9 6.7 12.6 15.5 47.2 8.4 3.3 17.4 5.5 2.0 14.2 12.0 12.6 15.7 15.6 12.8 18.5 11.0 18.2 15.9 13.1 15.5 16.7 14.7 4.1 10.5 8.3 11.0 17.0 15.1 25.4 15.7 20.8 8.0 13.9 67.2 10.5 11.9 9.6 21.3 13.9 8.8 20.8 15.2 5.8 10.1 14.6 13.2 9.8 30.9 2.5 13.3 2.2 13.9 13.3 18.1 12.4 36.8 14.7 14.4 4.1 11.9 3.1 19.3 10.6 18.4 11.9 15.2 13.9 4.3 8.1 16.1 7.7 5.1 3.9 8.5 10.3 4.8 3.6 13.5 6.4 5.6 0.0 0.1 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.3 0.0 0.1 0.0 0.2 0.0 0.0 6.2 9.6 8.6 8.6 6.3 6.1 10.6 9.1 8.1 6.7 8.4 12.6 10.3 0.0 6.1 18.6 6.2 4.8 8.3 6.1 6.2 36.9 11.1 11.0 20.1 5.7 6.7 7.3 29.2 19.6 3.0 12.5 5.9 13.3 144.6 7.1 11.1 11.4 16.1 8.2 21.1 13.1 21.3 12.9 9.7 7.5 0.0 30.1 9.3 6.0 17.2 21.9 17.8 7.6 8.2 4.7 4.2 347.6 17.1 6.9 5.4 5.6 5.8 22.7 2.1 18.6 26.8 11.7 6.9 15.4 9.5 10.5 7.0 17.7 4.9 29.8 6.6 11.3 12.9 98.2 24.7 8.2 5.1 17.4 4.9 34.1 9.0 6.1 PTGES "MGST-IV, MGST1-L1, MGST1L1, PIG12, TP53I12" ENSG00000148344 "Prostaglandin E synthase" O14684 9 129738331-129753042 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism, Prostaglandin biosynthesis, Prostaglandin metabolism" "Isomerase, Oxidoreductase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "seminal vesicle: 84.2;urinary bladder: 78.6" "Cell type enhanced" "Detected in many" "Basal respiratory cells: 101.2;Cytotrophoblasts: 146.0;Extravillous trophoblasts: 293.1;Syncytiotrophoblasts: 276.2" "Cancer enhanced" "Detected in all" "urothelial cancer: 69.6" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 7 "basophil: 28.9" "Lineage enriched" "Detected in many" 7 "granulocytes: 28.9" "Cell line enhanced" "Detected in many" "ASC diff: 147.7;BEWO: 162.7;GAMG: 292.8;HaCaT: 216.3;SK-BR-3: 157.6;U-2197: 404.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA045064 Enhanced Supported "Endoplasmic reticulum" NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 28: Placenta - Pregnancy" "Cluster 18: U-2197 - ECM organization" "Cluster 38: Extravillous trophoblasts - Unknown function" "Endoplasmic reticulum" "HPA045064: AB_10795889" "unprognostic (2.92e-3)" "unprognostic (1.09e-1)" "prognostic unfavorable (2.32e-4)" "unprognostic (2.54e-2)" "unprognostic (1.94e-3)" "unprognostic (1.25e-1)" "unprognostic (5.38e-3)" "unprognostic (1.24e-3)" "unprognostic (2.92e-1)" "unprognostic (1.61e-1)" "prognostic unfavorable (7.97e-5)" "unprognostic (2.22e-1)" "unprognostic (4.66e-2)" "unprognostic (9.78e-3)" "unprognostic (3.19e-2)" "unprognostic (1.30e-1)" "unprognostic (5.20e-2)" 36.7 1.4 4.1 13.9 3.6 7.8 25.5 3.9 4.5 26.1 3.5 9.2 2.8 3.7 19.0 17.8 5.4 9.0 8.5 4.5 5.1 8.1 0.7 7.8 7.6 6.1 5.8 2.2 1.6 42.1 1.9 58.4 7.1 13.7 4.2 0.0 30.8 84.2 1.3 42.3 9.1 4.1 4.1 2.5 7.1 16.9 4.7 4.2 3.7 1.1 30.7 78.6 20.0 3.5 1.5 94.9 0.1 46.6 147.7 51.9 162.7 7.4 64.2 1.1 1.7 5.6 71.7 0.1 2.7 18.0 292.8 216.3 0.7 7.2 0.6 0.3 0.5 0.0 62.5 0.4 3.5 0.0 0.0 30.9 49.0 0.9 0.3 1.4 0.0 0.9 0.0 0.1 0.7 1.7 0.2 0.0 1.2 46.7 8.2 0.2 0.0 0.3 5.3 102.2 0.8 3.6 87.1 157.6 0.8 6.3 83.3 0.0 0.5 0.1 0.4 404.8 0.0 0.0 0.0 0.0 78.8 0.1 0.7 28.9 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 4.0 0.0 0.0 0.3 4.1 3.6 3.9 4.5 4.5 5.1 6.1 5.8 7.1 4.1 4.7 3.5 3.4 0.0 0.0 0.3 0.3 17.8 8.9 101.2 10.8 0.0 29.7 19.7 0.1 0.0 53.2 3.7 0.0 146.0 0.6 0.0 1.9 13.4 0.6 1.6 2.3 4.0 7.3 0.0 1.0 1.1 293.1 70.7 0.0 5.0 1.3 61.5 0.0 0.0 17.5 0.0 2.8 6.6 30.5 0.0 21.6 0.4 0.3 13.2 14.2 7.5 7.2 0.0 0.0 0.0 0.2 8.1 0.2 0.0 0.3 8.2 0.3 0.5 6.7 0.0 0.0 0.8 13.5 0.3 0.0 5.5 43.0 276.2 0.8 0.2 0.4 49.2 PTK2 "FADK, FAK, FAK1, PPP1R71" ENSG00000169398 "Protein tyrosine kinase 2" Q05397 8 140657900-141002216 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Angiogenesis "Developmental protein, Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 295.2;Excitatory neurons: 584.9;Oligodendrocyte precursor cells: 353.9;Oligodendrocytes: 791.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001842, CAB004036, HPA029671" Approved Supported "Vesicles,Focal adhesion sites,Cytosol" NA Yes 25000 "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 57: Non-specific - Angiogenesis" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Focal adhesion sites" "Vesicles, Cytosol" "CAB004036: AB_2269034, HPA001842: AB_1855891, HPA029671: AB_10610288" "prognostic unfavorable (3.21e-4)" "unprognostic (3.86e-2)" "unprognostic (1.95e-1)" "prognostic unfavorable (9.11e-4)" "unprognostic (1.93e-1)" "unprognostic (2.28e-1)" "unprognostic (3.02e-2)" "unprognostic (1.27e-1)" "unprognostic (1.97e-1)" "unprognostic (2.96e-2)" "unprognostic (1.06e-2)" "unprognostic (2.38e-1)" "unprognostic (2.80e-2)" "unprognostic (2.94e-2)" "unprognostic (1.11e-1)" "unprognostic (1.53e-1)" "unprognostic (2.90e-2)" 51.0 40.4 83.8 19.5 115.1 6.7 42.1 62.4 99.9 40.3 51.0 37.2 25.8 37.3 49.7 25.6 34.0 32.1 36.9 84.5 77.3 42.6 30.1 39.4 25.3 79.1 87.6 33.7 32.1 53.1 21.3 74.2 81.0 34.0 35.3 35.5 39.9 41.6 38.7 29.6 29.5 37.6 67.6 22.8 32.8 38.9 86.7 11.9 38.7 39.4 25.8 43.9 34.0 154.5 52.6 81.9 111.0 40.3 45.8 48.8 71.6 50.8 70.0 46.3 45.3 35.9 42.1 31.7 111.7 65.3 65.0 60.3 66.1 116.0 69.6 0.3 30.8 70.1 44.3 50.0 62.5 0.1 31.8 33.4 55.8 58.0 81.0 121.5 139.0 44.0 72.0 0.8 62.9 91.0 0.9 0.7 43.2 113.2 90.3 46.8 60.9 1.5 97.7 117.3 43.9 54.8 79.0 25.0 52.0 97.2 59.2 1.2 84.9 45.2 85.5 54.0 58.1 0.0 0.6 3.4 58.7 0.6 62.9 1.6 3.3 0.0 0.2 1.4 0.0 5.3 0.6 0.0 4.5 6.3 4.4 1.6 1.3 4.7 0.8 6.1 0.2 3.9 83.8 115.1 62.4 99.9 84.5 77.3 79.1 87.6 81.0 67.6 86.7 154.5 71.3 32.1 33.1 295.2 20.6 33.3 70.1 36.3 64.9 55.2 29.3 23.5 29.6 32.9 32.1 55.2 60.5 37.0 8.0 23.1 23.5 27.2 68.4 29.3 43.3 54.3 25.8 8.4 584.9 23.3 53.7 37.2 37.8 46.5 9.5 84.7 37.5 15.7 8.1 67.3 263.6 23.0 30.5 15.2 15.9 38.8 23.9 19.4 24.9 159.3 3.9 40.9 0.0 353.9 791.4 43.1 23.5 21.8 1.7 82.4 29.3 25.6 33.7 55.0 98.6 32.7 128.4 88.9 65.5 42.8 25.9 33.2 3.4 67.0 24.1 87.3 PTK2B "CADTK, CAKB, FAK2, PTK, PYK2, RAFTK" ENSG00000120899 "Protein tyrosine kinase 2 beta" Q14289 8 27311482-27459391 "Disease related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Adaptive immunity, Angiogenesis, Immunity" "Kinase, Transferase, Tyrosine-protein kinase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 106.3;brain: 102.9" "Cell type enhanced" "Detected in many" "Excitatory neurons: 109.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "Daudi: 127.4;REH: 141.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003850, HPA026091, HPA026276" Approved Supported "Plasma membrane,Cytosol" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 10: Brain - Neuronal signaling" "Cluster 14: REH - Unknown function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane, Cytosol" "CAB003850: AB_562205, HPA026091: AB_10599739, HPA026276: AB_10601234" "unprognostic (2.36e-2)" "prognostic favorable (3.32e-4)" "unprognostic (1.06e-1)" "unprognostic (7.36e-3)" "unprognostic (3.72e-2)" "unprognostic (3.11e-2)" "unprognostic (2.70e-2)" "unprognostic (2.13e-2)" "unprognostic (3.23e-1)" "unprognostic (1.45e-1)" "unprognostic (5.74e-2)" "unprognostic (3.32e-1)" "unprognostic (2.40e-3)" "unprognostic (1.44e-1)" "unprognostic (1.38e-1)" "prognostic favorable (5.11e-4)" "unprognostic (3.33e-3)" 19.7 10.8 46.9 52.6 54.4 106.3 11.5 22.8 102.9 11.5 38.3 29.8 34.1 9.9 8.9 19.2 15.6 12.7 10.6 96.3 8.5 15.9 15.2 28.6 78.3 0.0 26.0 4.7 12.6 7.1 13.7 8.0 0.0 25.5 23.5 4.4 26.6 12.3 5.0 45.2 48.8 10.7 0.2 78.3 22.2 9.5 27.0 86.0 12.5 5.4 73.6 21.0 15.1 37.0 38.2 10.4 2.8 3.0 76.6 5.5 21.5 2.9 1.9 1.9 2.7 9.9 21.5 127.4 4.0 5.8 3.1 34.3 1.1 31.3 1.1 8.7 0.8 26.4 10.6 2.0 15.7 28.5 45.5 41.6 46.0 2.6 17.3 13.0 1.0 36.0 31.7 85.6 2.1 4.0 49.1 57.0 2.2 33.0 2.6 141.2 0.7 88.3 8.5 29.5 19.2 3.5 13.4 9.3 5.0 6.5 11.5 72.1 17.5 1.3 2.8 2.5 1.0 68.0 32.0 68.9 5.2 60.6 2.4 47.3 48.4 36.9 33.9 43.0 22.2 46.0 17.0 24.3 36.1 46.6 20.8 25.9 45.8 29.0 53.5 11.7 18.2 50.1 46.9 54.4 22.8 102.9 96.3 8.5 0.0 26.0 0.0 0.2 27.0 37.0 6.9 3.2 29.8 16.6 64.3 37.7 38.7 19.7 6.8 5.4 5.9 7.7 3.7 8.6 13.0 14.7 0.0 2.9 33.4 65.5 0.0 8.0 1.2 7.1 1.8 9.6 7.8 20.2 109.2 8.3 26.5 3.5 22.4 5.3 28.5 1.1 5.0 24.1 23.1 8.4 9.2 21.9 10.2 68.4 32.1 1.0 1.5 55.3 8.8 22.5 62.5 2.8 70.0 7.5 15.1 13.3 42.0 0.7 68.1 18.6 44.6 16.1 13.9 3.9 0.0 3.3 3.3 4.2 6.4 4.8 30.1 1.9 46.6 1.0 18.1 17.9 PTK6 BRK ENSG00000101213 "Protein tyrosine kinase 6" Q13882 20 63528001-63537376 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 109.4;skin 1: 53.9;vagina: 43.2" "Cell type enhanced" "Detected in many" "Distal enterocytes: 132.1;Gastric mucus-secreting cells: 59.1;Intestinal goblet cells: 42.5;Paneth cells: 97.6;Proximal enterocytes: 80.2;Squamous epithelial cells: 48.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in some" "A-431: 22.1;CAPAN-2: 41.4;HaCaT: 33.9;hTCEpi: 45.0;OE19: 57.0;RT4: 26.4;T-47d: 25.2" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB032952, HPA036070, HPA036071" Approved Supported "Nucleoplasm,Nuclear bodies,Plasma membrane,Cytosol" NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "Nuclear bodies, Plasma membrane, Cytosol" "CAB032952: AB_634461, HPA036070: AB_10602292, HPA036071: AB_10669982" "unprognostic (2.32e-2)" "unprognostic (1.36e-1)" "unprognostic (1.05e-1)" "unprognostic (2.42e-2)" "unprognostic (1.41e-1)" "unprognostic (1.35e-1)" "unprognostic (1.04e-1)" "unprognostic (2.29e-1)" "unprognostic (3.03e-1)" "unprognostic (3.72e-2)" "prognostic unfavorable (1.96e-4)" "unprognostic (1.28e-1)" "prognostic unfavorable (1.26e-9)" "unprognostic (4.19e-2)" "unprognostic (1.74e-1)" "unprognostic (1.73e-1)" "unprognostic (4.24e-2)" 0.5 0.1 0.6 3.6 1.7 0.8 3.8 2.9 1.7 19.8 0.0 26.5 28.9 0.4 0.1 109.4 0.4 3.5 0.2 0.6 0.9 0.8 5.2 2.6 0.6 1.6 1.0 0.3 3.6 0.0 0.2 0.3 1.7 3.1 15.7 0.8 19.1 0.6 0.6 53.9 22.2 0.8 0.6 0.8 26.2 0.3 1.1 0.3 0.2 0.0 6.4 9.8 43.2 5.4 22.1 2.6 0.3 0.3 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.5 41.4 0.1 7.2 0.0 0.1 33.9 0.0 0.1 0.0 5.4 0.4 0.0 10.2 0.1 0.1 0.0 6.7 0.0 45.0 0.0 0.2 0.2 0.0 0.1 0.2 2.5 0.2 12.5 0.0 0.2 0.2 57.0 15.5 0.1 1.2 0.5 0.0 26.4 0.3 2.2 2.6 8.1 0.0 0.1 25.2 1.6 0.2 0.3 0.4 0.8 0.3 0.5 0.1 0.1 0.4 0.5 1.1 0.4 0.7 0.1 0.1 0.5 0.5 0.3 0.1 0.0 1.3 0.3 0.1 0.1 0.3 0.0 0.4 0.1 0.1 0.3 0.6 1.7 2.9 1.7 0.6 0.9 1.6 1.0 1.7 0.6 1.1 5.4 0.3 12.8 25.6 0.3 1.4 5.9 2.6 7.7 5.2 2.2 7.0 4.3 0.4 12.8 14.9 0.0 2.1 0.2 0.2 132.1 0.0 1.4 0.2 0.4 0.5 3.2 5.4 0.0 0.1 1.6 0.2 1.4 59.1 1.3 9.5 0.2 0.4 1.7 0.6 0.0 0.1 42.5 2.0 2.2 2.0 0.0 0.3 2.6 0.0 0.0 1.0 1.6 1.0 0.0 0.8 17.6 97.6 0.0 0.1 1.5 80.2 0.2 8.9 3.7 0.0 2.3 1.1 0.2 0.3 48.0 15.5 0.1 2.0 0.2 32.1 15.9 PYGB ENSG00000100994 "Glycogen phosphorylase B" P11216 20 25248085-25298012 "Candidate cardiovascular disease genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Carbohydrate metabolism, Glycogen metabolism" "Allosteric enzyme, Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 122.8;Distal enterocytes: 185.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "PC-3: 407.8;SK-MEL-30: 528.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031067 Approved Approved Cytosol NA NA 14000000 "Cluster 39: Non-specific - mRNA processing" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "HPA031067: AB_2673722" "unprognostic (6.13e-2)" "unprognostic (5.98e-2)" "unprognostic (1.21e-1)" "unprognostic (2.22e-1)" "unprognostic (1.21e-1)" "unprognostic (1.05e-1)" "prognostic unfavorable (4.37e-4)" "prognostic unfavorable (1.10e-4)" "unprognostic (1.23e-3)" "unprognostic (8.39e-3)" "unprognostic (1.58e-3)" "unprognostic (1.98e-1)" "unprognostic (1.22e-2)" "unprognostic (3.41e-2)" "unprognostic (1.69e-1)" "unprognostic (1.40e-1)" "prognostic unfavorable (1.43e-4)" 50.8 36.4 78.2 27.7 77.9 14.1 61.1 84.1 82.4 37.0 35.4 140.9 27.0 51.9 21.4 106.6 37.8 39.1 163.9 77.3 74.9 43.7 14.6 32.1 19.1 85.4 80.8 25.9 25.4 18.1 61.5 11.5 81.2 107.9 72.6 25.4 125.1 106.3 18.7 85.3 44.8 59.8 84.7 22.6 51.3 25.2 80.3 18.4 45.2 10.5 17.3 154.2 53.0 84.8 31.5 220.1 39.1 38.3 97.9 182.7 28.7 62.2 80.9 51.4 43.0 50.1 38.0 37.1 71.8 83.6 96.1 123.9 44.5 165.8 27.9 21.1 27.5 29.5 18.6 86.9 115.7 44.7 40.0 107.1 152.4 130.5 191.3 63.5 66.6 23.0 16.5 91.4 73.0 87.1 45.1 34.6 35.2 38.2 407.8 33.7 71.0 49.8 280.5 56.8 58.4 36.5 42.7 74.0 528.7 31.0 51.9 28.4 147.4 60.3 36.5 65.1 128.7 35.2 58.8 14.4 67.9 34.8 335.3 4.6 14.1 7.1 10.2 19.4 9.9 5.4 8.1 9.2 14.5 4.6 10.3 12.9 3.3 11.2 23.4 7.1 9.6 23.4 78.2 77.9 84.1 82.4 77.3 74.9 85.4 80.8 81.2 84.7 80.3 84.8 10.0 9.6 34.6 43.1 8.7 11.9 23.1 20.7 22.2 35.8 31.6 43.6 122.8 11.5 14.6 25.8 37.5 7.1 10.7 185.2 11.7 17.6 3.5 12.7 17.2 13.5 28.2 8.6 22.9 16.5 7.2 15.3 40.2 21.6 6.3 16.2 8.9 5.8 10.8 18.5 26.9 47.3 57.0 13.8 10.7 9.2 27.4 18.5 35.6 15.0 16.6 21.3 15.5 11.6 19.1 27.0 68.5 86.5 22.9 17.6 20.9 11.1 11.9 9.3 0.0 13.5 23.1 2.0 8.5 15.3 10.1 4.4 12.9 20.3 72.0 9.7 PYGL GSD6 ENSG00000100504 "Glycogen phosphorylase L" P06737 14 50857891-50944483 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Carbohydrate metabolism, Glycogen metabolism" "Allosteric enzyme, Glycosyltransferase, Transferase" "Disease variant, Glycogen storage disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 145.6" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 151.2;Hofbauer cells: 177.6;Muller glia cells: 265.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "eosinophil: 141.1;neutrophil: 153.7" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HaCaT: 279.1;HMC-1: 304.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA000962, HPA004119" Enhanced Supported "Plasma membrane,Cytosol" NA NA 16000000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 85: Liver - Metabolism" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 5: Muller glia cells - Visual perception" "Plasma membrane, Cytosol" "HPA000962: AB_1079722, HPA004119: AB_1079723" "unprognostic (2.70e-2)" "unprognostic (8.64e-3)" "unprognostic (1.46e-2)" "unprognostic (8.55e-2)" "unprognostic (9.41e-2)" "prognostic unfavorable (5.97e-4)" "unprognostic (1.66e-1)" "unprognostic (1.34e-2)" "unprognostic (3.34e-1)" "unprognostic (1.94e-2)" "prognostic unfavorable (2.63e-4)" "unprognostic (4.45e-3)" "unprognostic (3.15e-3)" "unprognostic (1.95e-2)" "unprognostic (1.76e-1)" "unprognostic (9.72e-2)" "unprognostic (1.12e-3)" 110.1 21.0 5.9 24.1 6.6 108.9 36.4 5.0 8.4 33.6 10.4 19.0 3.7 20.7 6.4 55.8 19.1 13.0 14.9 5.2 6.2 10.2 145.6 26.1 6.3 10.7 17.6 18.2 5.7 21.1 7.5 49.3 8.7 13.0 24.0 78.2 26.8 29.7 5.1 37.0 8.4 26.7 8.6 49.4 9.6 5.2 9.0 4.8 10.2 5.8 6.8 41.7 38.1 10.3 145.7 40.8 10.1 64.3 47.0 56.2 114.5 28.6 24.1 77.4 117.3 107.4 18.3 0.1 54.4 171.7 91.2 279.1 107.0 144.8 132.0 0.5 46.8 28.0 60.5 82.4 83.8 106.9 304.4 119.4 56.8 104.1 43.6 75.4 69.3 0.8 11.6 0.5 55.4 144.7 0.4 141.7 39.3 12.8 152.0 2.7 36.2 6.1 104.7 95.1 4.5 4.4 131.0 43.3 1.7 38.6 20.6 200.4 3.2 29.7 49.6 56.0 92.9 1.2 0.3 0.5 27.3 107.7 15.9 50.2 55.9 141.1 0.0 24.2 0.0 0.0 0.0 0.0 27.3 0.0 0.0 0.0 153.7 0.6 15.7 1.2 0.2 24.8 5.9 6.6 5.0 8.4 5.2 6.2 10.7 17.6 8.7 8.6 9.0 10.3 6.7 22.4 6.3 1.3 1.8 30.7 10.5 40.5 6.8 4.6 7.0 3.8 3.4 5.7 35.4 7.3 0.0 28.9 0.2 11.2 3.9 10.9 1.0 35.4 18.9 7.8 1.2 9.0 1.8 2.1 151.2 18.8 6.6 62.6 6.3 9.3 8.2 65.4 177.6 1.7 2.2 7.1 14.2 56.7 7.9 1.5 14.3 54.6 19.6 15.9 52.4 265.1 2.1 14.1 0.6 7.4 5.2 21.8 1.8 9.7 0.0 6.4 24.5 11.9 6.6 15.4 8.8 0.7 1.4 22.4 22.3 21.1 2.3 4.0 14.0 9.2 PYGM GSD5 ENSG00000068976 "Glycogen phosphorylase, muscle associated" P11217 11 64746389-64759974 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Carbohydrate metabolism, Glycogen metabolism" "Allosteric enzyme, Glycosyltransferase, Transferase" "Disease variant, Glycogen storage disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 65 "skeletal muscle: 8468.3;tongue: 3594.2" "Cell type enhanced" "Detected in many" "Astrocytes: 29.7;Cardiomyocytes: 47.5;Late spermatids: 49.2;Peritubular cells: 44.0;Skeletal myocytes: 64.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 6 "basophil: 8.1" "Lineage enriched" "Detected in many" 6 "granulocytes: 8.1" "Cell line enhanced" "Detected in some" "HSkMC: 3.7;NB-4: 2.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA056003 Enhanced NA NA 10000000 "Cluster 10: Basophils - Unknown function" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 37: Myocytes - Muscle contraction" "HPA056003: AB_2683006" "unprognostic (3.33e-1)" "unprognostic (6.03e-3)" "unprognostic (3.87e-4)" "unprognostic (1.95e-3)" "unprognostic (8.71e-2)" "unprognostic (1.09e-2)" "unprognostic (1.25e-3)" "unprognostic (2.92e-1)" "unprognostic (3.88e-1)" "unprognostic (3.08e-2)" "unprognostic (1.12e-1)" "unprognostic (2.64e-1)" "unprognostic (6.33e-6)" "unprognostic (3.37e-3)" "unprognostic (1.81e-1)" "unprognostic (1.62e-2)" "unprognostic (5.68e-2)" 15.2 3.0 35.4 2.1 30.1 1.2 7.7 55.5 29.4 5.8 15.5 25.5 1.5 10.4 6.4 92.2 14.6 3.8 70.8 26.8 26.1 2.4 1.2 2.7 2.2 48.8 30.4 4.0 1.6 0.3 1.7 1.4 39.6 25.6 3.6 2.9 50.0 26.3 8468.3 4.2 7.0 14.7 44.9 3.3 6.9 6.7 47.3 1.3 5.2 3594.2 1.2 16.7 5.2 38.1 0.1 0.0 0.7 0.1 0.5 0.7 0.1 0.0 0.0 0.1 0.0 0.3 0.3 0.6 0.2 0.0 0.1 0.1 0.2 0.0 0.0 0.6 0.1 0.3 0.2 0.0 0.3 0.4 0.1 3.7 0.2 0.2 0.1 0.0 0.0 1.1 0.7 0.6 0.0 1.1 0.7 2.2 0.7 0.1 0.1 0.4 0.7 0.1 0.0 0.1 0.2 0.0 0.2 0.3 0.4 0.4 0.3 0.4 0.3 0.0 0.4 0.1 0.0 1.0 1.4 0.4 0.0 0.1 0.0 8.1 0.0 0.0 0.2 0.0 0.0 0.9 0.0 0.1 0.0 1.1 0.0 0.1 0.1 1.3 0.0 0.2 0.2 0.1 35.4 30.1 55.5 29.4 26.8 26.1 48.8 30.4 39.6 44.9 47.3 38.1 2.4 0.0 2.3 29.7 3.0 0.8 0.6 0.2 5.2 3.5 2.9 4.7 47.5 0.0 0.8 0.0 4.2 0.6 1.9 1.0 0.0 0.1 11.7 1.6 5.2 2.0 0.0 0.0 0.2 0.0 0.2 5.1 1.1 4.0 0.0 0.8 1.8 0.0 0.5 0.0 0.2 0.9 0.0 0.6 1.3 49.2 16.4 2.3 0.0 1.0 0.5 9.9 4.1 0.5 0.4 0.3 0.2 44.0 0.3 1.3 0.6 0.0 0.1 1.3 6.6 64.3 12.8 1.2 0.9 2.5 0.6 0.1 2.9 0.9 1.1 0.3 QPCT "GCT, QC" ENSG00000115828 "Glutaminyl-peptide cyclotransferase" Q16769 2 37342827-37373322 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted secreted proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "adrenal gland: 170.3;epididymis: 104.0" "Group enriched" "Detected in many" 4 "Enteroendocrine cells: 217.0;Ionocytes: 138.4;Langerhans cells: 163.4;Melanocytes: 528.3" "Cancer enhanced" "Detected in all" "melanoma: 97.4" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 4 "neutrophil: 1527.7" "Lineage enriched" "Detected in many" 4 "granulocytes: 1527.7" "Cell line enhanced" "Detected in many" "SCLC-21H: 117.1;SK-MEL-30: 426.8;U-266/84: 341.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008406 Enhanced Approved Cytosol "Secreted to blood" NA NA 390000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 68: Epididymis - Unknown function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 48: Smooth muscle cells - ECM organization" Cytosol "HPA008406: AB_1855981" "unprognostic (6.25e-3)" "unprognostic (6.69e-2)" "unprognostic (4.95e-2)" "unprognostic (1.44e-1)" "unprognostic (1.44e-2)" "unprognostic (9.32e-2)" "unprognostic (1.13e-3)" "unprognostic (9.73e-2)" "unprognostic (2.71e-3)" "unprognostic (7.86e-2)" "unprognostic (3.67e-2)" "unprognostic (1.17e-1)" "unprognostic (6.78e-2)" "unprognostic (7.76e-3)" "unprognostic (1.21e-1)" "unprognostic (9.48e-3)" "unprognostic (3.62e-3)" 5.6 170.3 8.4 14.2 7.5 47.3 15.8 5.1 11.5 21.2 4.2 25.3 5.6 9.8 104.0 3.4 2.2 10.8 5.1 8.9 27.4 6.1 2.6 5.6 8.1 9.7 11.6 1.0 13.7 14.8 27.0 9.2 14.7 7.2 10.2 11.9 25.5 6.7 4.1 36.3 4.5 8.3 7.8 13.9 7.6 2.0 20.3 5.1 3.8 2.8 12.5 15.2 4.6 6.7 1.0 40.7 0.1 0.0 6.0 13.3 0.1 6.6 86.5 6.4 10.1 2.9 7.1 0.2 3.0 32.6 72.9 0.1 2.7 0.6 10.3 0.6 76.0 18.7 0.3 7.7 0.6 3.0 0.1 8.5 0.0 47.3 0.2 0.4 26.2 0.0 0.0 0.0 0.2 4.5 0.0 1.7 0.6 0.3 0.0 0.0 0.0 0.8 42.6 10.9 117.1 0.2 6.4 1.4 426.8 8.0 0.7 2.9 19.4 0.0 0.2 0.1 0.6 15.3 341.7 0.3 25.8 0.3 0.0 9.8 344.8 3.2 0.4 38.7 1.0 2.6 0.6 0.5 124.7 1.2 0.5 0.3 1527.7 0.2 3.3 2.4 0.1 169.8 8.4 7.5 5.1 11.5 8.9 27.4 9.7 11.6 14.7 7.8 20.3 6.7 1.8 3.2 2.3 0.3 12.5 39.0 13.6 40.0 2.2 21.8 7.9 8.5 1.1 1.5 17.7 22.0 2.1 0.7 0.8 6.1 1.9 45.4 0.6 2.6 24.7 17.5 217.0 1.7 8.5 2.4 6.1 26.7 3.1 4.0 55.3 1.6 22.5 0.3 20.5 43.7 7.3 6.6 138.4 21.2 163.4 2.9 3.1 26.8 528.3 6.5 64.3 0.8 3.1 3.0 1.3 31.8 1.8 23.7 26.0 9.1 0.2 11.7 4.3 3.2 13.1 0.6 6.6 1.7 0.7 0.6 14.5 4.7 5.6 5.0 7.3 5.8 QPCTL FLJ20084 ENSG00000011478 "Glutaminyl-peptide cyclotransferase like" Q9NXS2 19 45692403-45703989 "Enzymes, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 5.5;granulocytes: 5.7;Inhibitory neurons: 6.5;Plasma cells: 9.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040797 Approved Supported "Golgi apparatus" NA NA "Cluster 40: NK-cells - Unknown function" "Cluster 18: Non-specific - Mitochondria" "Cluster 2: Karpas-707 - Immune response" "Cluster 55: Plasma cells - Humoral immune response" "Golgi apparatus" "HPA040797: AB_10794148" "unprognostic (6.50e-2)" "unprognostic (4.14e-2)" "unprognostic (2.09e-1)" "unprognostic (7.50e-2)" "unprognostic (1.90e-1)" "unprognostic (2.26e-1)" "unprognostic (8.41e-3)" "unprognostic (2.30e-2)" "unprognostic (9.46e-2)" "unprognostic (1.69e-1)" "unprognostic (3.14e-2)" "unprognostic (6.05e-2)" "prognostic unfavorable (2.15e-8)" "unprognostic (1.07e-1)" "unprognostic (1.75e-1)" "unprognostic (4.02e-2)" "unprognostic (5.71e-2)" 4.1 7.8 3.9 3.1 3.9 4.1 4.9 3.6 4.8 4.9 4.1 5.9 4.7 4.8 3.7 4.7 4.8 2.5 3.4 4.2 4.0 5.3 9.2 6.2 4.7 4.5 3.8 6.6 7.5 4.4 7.0 3.7 4.5 6.5 3.9 2.1 6.7 3.4 1.5 5.2 5.5 2.5 3.2 8.5 6.1 4.4 4.2 2.4 6.7 0.8 3.5 4.6 4.4 3.9 16.7 10.8 8.5 36.9 8.6 4.1 6.4 10.3 15.7 15.0 24.7 11.2 12.3 19.7 11.1 11.5 15.4 9.5 10.0 11.9 8.9 5.0 12.7 6.7 10.9 24.6 14.6 7.5 12.0 7.6 14.9 12.6 17.3 10.7 13.6 10.8 9.7 32.1 9.5 13.0 7.0 7.7 5.5 14.2 5.4 7.8 6.4 16.5 16.2 8.0 7.6 4.7 10.6 8.8 18.2 3.7 6.4 10.6 8.4 7.4 12.4 7.3 10.4 28.6 20.2 18.2 26.0 17.2 5.8 1.4 0.3 0.2 1.4 0.5 0.9 0.9 0.6 0.3 0.8 0.6 0.5 0.7 1.3 1.4 0.3 1.0 0.3 0.2 3.9 3.9 3.6 4.8 4.2 4.0 4.5 3.8 4.5 3.2 4.2 3.9 0.5 0.0 1.5 2.3 3.3 1.3 1.2 1.1 0.6 1.1 0.7 0.6 0.8 1.5 1.2 0.0 0.0 0.8 2.1 1.2 0.0 0.6 5.4 0.9 1.4 0.7 0.0 1.3 5.5 0.4 1.4 0.7 1.5 1.4 5.7 0.7 0.0 1.3 0.9 1.7 6.5 0.4 0.0 0.6 1.8 1.3 0.0 1.6 1.8 0.0 0.7 0.3 1.0 3.5 1.6 0.6 0.1 0.0 9.8 1.2 0.7 0.1 2.2 2.4 0.0 0.6 1.1 1.0 0.3 1.4 1.1 0.8 2.4 1.5 1.0 0.5 QPRT QPRTase ENSG00000103485 "Quinolinate phosphoribosyltransferase" Q15274 16 29663279-29698699 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Pyridine nucleotide biosynthesis" "Glycosyltransferase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "kidney: 119.4;liver: 183.5" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 404.7;Extravillous trophoblasts: 315.1;Hepatocytes: 367.4;Proximal tubular cells: 598.8;Syncytiotrophoblasts: 215.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 6 "classical monocyte: 4.2;intermediate monocyte: 5.3;myeloid DC: 5.8;non-classical monocyte: 9.0;plasmacytoid DC: 3.1" "Group enriched" "Detected in many" 8 "dendritic cells: 5.8;monocytes: 9.0" "Cell line enhanced" "Detected in many" "EFO-21: 597.1;Hep G2: 258.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA011887, HPA076010" Enhanced Approved Vesicles "Intracellular and membrane" NA NA 780000 "Cluster 7: Monocytes - Unknown function" "Cluster 81: Kidney & Liver - Metabolism" "Cluster 38: EFO-21 - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Vesicles "HPA011887: AB_2668555, HPA076010: " "prognostic unfavorable (5.10e-5)" "unprognostic (2.00e-1)" "unprognostic (9.48e-2)" "unprognostic (2.88e-1)" "prognostic unfavorable (9.31e-4)" "unprognostic (1.44e-2)" "unprognostic (8.75e-2)" "unprognostic (1.22e-1)" "unprognostic (8.16e-2)" "unprognostic (1.01e-2)" "unprognostic (2.39e-1)" "unprognostic (6.81e-2)" "unprognostic (3.37e-2)" "unprognostic (1.33e-2)" "unprognostic (2.65e-1)" "unprognostic (1.63e-1)" "unprognostic (1.58e-2)" 8.4 89.4 20.6 4.3 20.2 4.8 6.7 25.8 19.8 50.6 19.4 19.2 61.6 26.1 95.2 4.0 43.6 10.2 26.8 18.5 22.2 119.4 183.5 9.2 6.8 28.6 26.6 31.0 34.5 16.2 5.8 27.3 32.4 7.0 15.2 7.5 13.4 26.1 5.1 5.1 30.3 13.7 23.6 17.2 7.1 4.1 22.8 8.2 6.5 1.2 5.2 10.5 11.5 23.3 0.6 1.4 51.8 56.4 8.8 21.6 167.8 6.0 5.2 8.6 11.0 145.9 91.9 2.3 597.1 10.8 10.0 1.0 18.5 0.6 4.5 0.8 16.7 27.1 2.2 258.0 52.5 4.1 10.4 69.8 1.4 4.8 0.2 12.8 0.2 28.2 75.1 2.9 0.4 154.6 17.6 100.3 162.1 1.9 0.2 89.3 16.3 58.5 47.9 4.2 48.6 103.5 0.0 142.1 118.8 85.1 106.5 112.8 0.6 2.5 24.9 0.9 0.5 1.8 4.9 18.8 4.4 10.4 8.1 0.0 4.2 0.3 0.8 5.3 0.9 0.1 0.6 0.7 5.8 0.0 0.1 0.4 0.8 0.4 9.0 3.1 0.9 1.9 20.6 20.2 25.8 19.8 18.5 22.2 28.6 26.6 32.4 23.6 22.8 23.3 3.1 9.6 24.8 5.2 10.1 3.6 11.7 0.5 1.8 3.3 5.0 2.0 43.2 8.6 3.0 64.4 0.0 404.7 5.8 84.5 50.9 1.2 0.0 93.8 49.5 5.5 28.3 10.5 1.3 55.2 315.1 35.8 0.5 81.0 5.1 6.7 9.7 367.4 147.5 6.7 5.6 47.3 0.0 21.2 18.3 0.5 29.2 19.8 42.7 12.2 4.4 20.8 3.1 11.1 0.5 11.5 78.5 27.1 8.7 4.2 161.0 598.8 1.5 5.0 6.6 3.3 16.2 0.5 3.0 0.2 2.0 215.6 5.7 36.5 104.7 8.3 QTRT1 TGT ENSG00000213339 "Queuine tRNA-ribosyltransferase catalytic subunit 1" Q9BXR0 19 10701430-10713437 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "tRNA processing" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Intestinal goblet cells: 260.9;Paneth cells: 224.5;Proximal enterocytes: 261.8;Undifferentiated cells: 280.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA042695, HPA048651, HPA049440" Approved Approved Mitochondria NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 29: Non-specific - Vesicular transport" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" Mitochondria "HPA042695: AB_2678119, HPA048651: AB_2680477, HPA049440: AB_2680767" "unprognostic (6.19e-2)" "prognostic favorable (7.63e-5)" "unprognostic (2.90e-2)" "unprognostic (3.05e-1)" "unprognostic (4.90e-2)" "prognostic favorable (4.90e-4)" "unprognostic (2.52e-1)" "unprognostic (8.76e-3)" "unprognostic (3.88e-1)" "unprognostic (4.81e-3)" "prognostic favorable (2.13e-4)" "unprognostic (1.14e-2)" "prognostic unfavorable (1.13e-6)" "unprognostic (2.04e-2)" "unprognostic (1.66e-1)" "unprognostic (3.13e-1)" "unprognostic (1.01e-3)" 17.2 27.1 11.2 11.8 11.4 13.4 18.1 10.0 15.9 18.4 9.4 20.0 10.3 22.7 2.7 20.5 20.9 7.3 21.4 11.8 11.3 18.3 30.2 12.5 12.2 10.8 10.6 24.4 51.9 9.6 17.6 7.7 11.1 16.9 5.0 6.1 22.3 9.2 20.5 18.3 15.2 6.1 10.8 14.8 20.7 6.4 11.3 7.0 20.7 10.2 5.1 17.6 16.4 11.6 41.5 32.3 14.6 44.1 15.3 18.2 19.7 20.8 18.3 23.8 22.9 25.6 15.0 47.1 50.1 11.5 14.4 26.6 13.8 24.9 7.7 28.1 20.8 30.4 13.3 55.7 26.6 46.4 25.7 27.8 20.3 15.3 22.1 10.5 24.2 25.5 35.0 50.2 11.8 64.2 39.7 56.5 40.3 25.3 53.5 41.2 19.9 72.2 18.8 26.1 48.4 21.6 33.0 33.4 27.8 6.2 21.5 19.0 19.5 35.0 20.3 58.2 49.7 56.7 48.3 23.3 19.3 55.0 44.4 1.9 16.6 0.4 29.6 31.4 37.4 42.0 31.7 26.4 34.0 40.8 33.3 27.5 1.3 43.9 16.6 39.8 37.9 21.3 11.2 11.4 10.0 15.9 11.8 11.3 10.8 10.6 11.1 10.8 11.3 11.6 23.2 0.0 4.5 47.3 36.6 63.7 63.5 59.0 65.4 36.7 42.6 48.6 7.3 30.0 24.5 57.0 50.1 47.8 27.3 157.0 64.6 25.8 1.6 19.8 28.8 24.7 192.5 30.3 32.8 27.6 39.7 33.5 23.9 18.8 16.5 43.7 18.2 33.9 28.8 90.9 31.4 260.9 42.7 15.8 30.9 2.6 50.7 12.8 49.8 8.4 10.5 22.0 7.2 21.6 30.0 13.9 224.5 37.6 53.2 43.6 261.8 80.3 22.6 57.9 19.7 40.7 31.1 12.9 24.6 36.9 41.9 28.0 27.0 67.4 280.7 37.2 RABGGTA PTAR3 ENSG00000100949 "Rab geranylgeranyltransferase subunit alpha" Q92696 14 24265538-24271611 "Enzymes, Predicted intracellular proteins" "Prenyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "esophagus: 59.2" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA043488 Approved NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "HPA043488: AB_10794887" "unprognostic (2.00e-1)" "unprognostic (8.37e-2)" "unprognostic (2.61e-3)" "unprognostic (1.13e-1)" "unprognostic (8.34e-2)" "unprognostic (1.39e-1)" "unprognostic (2.78e-1)" "unprognostic (5.78e-2)" "unprognostic (3.89e-2)" "unprognostic (7.11e-2)" "unprognostic (3.12e-2)" "unprognostic (1.12e-1)" "prognostic favorable (5.44e-4)" "unprognostic (1.77e-1)" "unprognostic (1.84e-1)" "prognostic favorable (1.51e-4)" "unprognostic (2.01e-1)" 11.3 14.7 6.9 7.7 7.0 10.0 11.3 7.6 9.4 14.7 6.1 12.2 11.0 9.3 10.0 59.2 12.1 9.2 16.3 7.5 8.5 13.7 14.8 13.9 9.8 8.3 7.7 10.6 17.7 16.9 15.2 7.8 8.2 12.2 8.5 3.1 20.1 8.3 19.1 19.9 13.1 6.9 7.4 17.1 16.3 11.8 7.9 9.0 11.9 12.5 12.4 10.0 19.4 8.1 10.6 13.0 6.8 10.6 8.9 17.4 31.9 15.2 12.8 21.4 19.4 12.2 17.4 13.1 11.8 16.3 9.5 20.4 7.0 33.2 9.2 20.8 14.4 8.6 11.0 45.9 17.9 18.8 36.3 19.9 35.9 11.4 13.5 11.6 19.7 16.4 9.0 16.1 16.3 41.0 12.5 10.1 2.3 14.0 19.2 9.3 6.2 14.5 20.5 15.6 16.9 9.7 10.5 29.9 12.8 9.4 12.5 13.7 14.5 11.2 7.8 6.1 10.5 17.2 13.9 8.7 9.5 11.5 17.6 11.9 25.7 17.1 16.0 46.8 13.3 16.3 15.3 12.4 32.0 10.4 12.8 10.0 7.3 16.9 33.1 5.4 18.1 18.4 6.9 7.0 7.6 9.4 7.5 8.5 8.3 7.7 8.2 7.4 7.9 8.1 9.3 9.6 11.6 4.6 18.0 17.7 19.6 61.6 35.9 7.7 13.8 14.0 12.4 15.7 28.1 5.5 6.2 38.0 14.4 25.0 15.6 23.4 3.3 9.7 5.8 9.3 13.1 7.8 5.1 27.1 31.1 10.1 23.4 11.9 36.2 8.3 9.7 7.1 26.5 11.8 4.3 14.5 26.4 17.9 10.4 7.7 9.0 18.3 16.0 3.7 18.8 9.0 12.3 4.0 3.7 39.3 23.7 7.2 20.3 15.4 27.7 20.4 15.5 5.3 6.6 5.8 12.0 3.3 34.2 36.9 12.4 57.3 16.8 10.3 18.0 20.9 RABGGTB ENSG00000137955 "Rab geranylgeranyltransferase subunit beta" P53611 1 75786197-75795086 "Enzymes, Predicted intracellular proteins" "Prenyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026585, HPA027167, HPA030793" Approved Supported Approved Vesicles NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Vesicles "HPA026585: AB_1856026, HPA027167: AB_1856027, HPA030793: " "unprognostic (4.83e-2)" "unprognostic (3.04e-1)" "unprognostic (2.09e-2)" "unprognostic (2.45e-2)" "unprognostic (9.02e-2)" "unprognostic (3.52e-2)" "prognostic unfavorable (9.80e-5)" "unprognostic (9.62e-3)" "unprognostic (2.93e-1)" "unprognostic (1.93e-1)" "unprognostic (2.23e-1)" "unprognostic (6.95e-2)" "prognostic unfavorable (1.12e-5)" "unprognostic (6.05e-2)" "unprognostic (1.56e-1)" "unprognostic (6.77e-2)" "unprognostic (3.89e-1)" 37.5 56.5 41.0 20.3 44.9 18.3 41.4 44.7 52.8 31.4 40.4 33.9 33.3 24.6 23.6 35.2 28.1 21.4 49.6 40.0 44.8 75.9 67.2 29.0 26.9 44.8 43.6 38.1 67.7 37.5 25.1 31.5 44.8 27.5 29.3 41.2 32.0 23.0 79.7 21.7 24.9 23.0 47.1 29.1 33.9 15.3 43.6 30.6 30.5 84.0 31.3 37.3 30.4 47.9 74.8 40.2 68.6 31.4 85.2 108.8 43.8 99.5 68.2 91.6 70.4 97.3 17.6 68.2 101.3 55.7 146.0 46.0 178.3 77.7 133.8 67.1 48.3 58.0 66.5 158.0 106.6 74.8 32.9 67.5 165.1 84.3 95.4 125.6 75.8 59.7 96.9 65.7 109.9 30.8 61.5 81.4 64.5 53.3 78.0 49.2 114.5 29.9 69.9 41.7 43.5 39.1 24.1 123.6 231.0 58.8 26.1 69.8 77.5 59.6 67.0 142.1 199.5 41.9 127.1 46.4 67.5 60.3 27.0 8.4 7.2 4.7 7.7 11.3 9.3 9.5 7.7 7.2 12.3 5.9 9.4 9.3 1.1 6.3 8.1 11.3 7.7 4.0 41.0 44.9 44.7 52.8 40.0 44.8 44.8 43.6 44.8 47.1 43.6 47.9 35.3 35.3 44.3 12.7 83.3 127.7 59.4 132.6 66.0 22.6 58.5 45.6 71.1 72.9 86.0 27.6 20.9 45.9 65.7 38.6 103.7 44.9 1.6 36.1 42.5 45.8 89.8 41.6 17.1 51.8 60.3 48.6 57.6 40.4 70.5 26.5 41.7 68.6 61.2 32.0 17.8 62.2 75.3 61.3 91.4 4.4 32.3 54.8 58.7 9.4 52.0 36.5 32.0 14.6 21.9 44.1 46.0 33.4 78.8 84.8 58.4 206.5 45.8 22.3 6.6 40.1 59.8 20.1 14.0 73.6 142.9 53.5 60.2 37.5 69.6 88.7 RAD18 RNF73 ENSG00000070950 "RAD18 E3 ubiquitin protein ligase" Q9NS91 3 8775402-8963773 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "DNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006716, HPA006724, HPA008752" Supported Approved Enhanced "Nucleoplasm,Nuclear bodies" NA Yes "Cluster 2: Granulocytes - Unknown function" "Cluster 9: Intestine - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" "Nucleoplasm, Nuclear bodies" "HPA006716: AB_2667650, HPA006724: AB_2667655, HPA008752: AB_2668129" "unprognostic (1.26e-1)" "unprognostic (1.07e-1)" "unprognostic (4.45e-2)" "unprognostic (1.25e-3)" "unprognostic (2.73e-2)" "unprognostic (6.15e-2)" "prognostic unfavorable (1.12e-4)" "unprognostic (2.01e-1)" "unprognostic (9.76e-2)" "unprognostic (1.17e-1)" "unprognostic (2.02e-2)" "prognostic unfavorable (3.73e-4)" "prognostic unfavorable (3.65e-5)" "unprognostic (1.97e-2)" "unprognostic (1.51e-1)" "unprognostic (7.92e-2)" "unprognostic (1.89e-2)" 2.7 2.3 1.2 3.3 1.5 5.2 5.3 1.3 1.7 3.2 0.5 3.8 10.1 2.8 1.9 3.4 2.3 3.1 1.8 1.5 0.9 1.6 2.7 2.7 4.6 1.6 1.0 2.8 1.7 2.0 1.3 3.0 1.5 3.2 4.9 2.6 3.2 1.6 1.3 4.5 6.5 2.8 1.2 3.5 2.2 2.9 1.1 5.8 3.7 1.0 4.4 2.5 2.9 2.3 16.2 15.2 12.3 7.4 3.0 6.4 14.9 25.0 8.5 23.5 16.1 13.7 10.1 19.8 4.7 14.2 13.8 5.6 13.1 13.0 23.8 12.2 17.2 16.9 16.1 8.2 1.9 22.7 13.9 2.4 4.6 23.3 15.7 6.3 7.7 17.1 18.2 19.0 20.9 18.6 22.9 15.9 17.2 12.7 28.5 18.0 13.6 15.6 6.9 12.2 5.1 11.5 11.2 10.5 8.2 9.7 11.0 9.8 6.4 19.4 10.5 16.8 21.7 9.6 16.1 43.7 14.3 24.5 14.6 6.4 1.6 5.1 1.5 1.7 2.8 1.9 2.1 2.7 2.0 1.9 2.2 1.6 0.7 2.8 1.1 3.6 3.0 0.8 1.2 1.5 1.3 1.7 1.5 0.9 1.6 1.0 1.5 1.2 1.1 2.3 5.7 16.0 9.8 6.2 7.7 11.1 7.5 6.4 5.7 4.6 7.3 11.7 2.2 4.3 7.5 3.7 2.1 9.0 8.6 5.2 1.9 9.6 4.2 4.0 5.8 4.6 1.8 7.2 20.9 8.2 12.4 6.8 3.6 4.9 13.9 14.8 6.1 3.1 7.1 3.3 15.7 6.5 2.0 5.2 5.6 3.0 4.1 4.6 3.6 14.0 7.1 3.2 8.2 16.1 14.3 10.2 4.3 2.6 8.7 6.4 4.0 3.1 4.1 2.3 6.6 4.3 6.9 26.2 14.0 6.0 11.8 6.7 7.5 9.3 6.3 3.6 RAF1 "c-Raf, CRAF, Raf-1" ENSG00000132155 "Raf-1 proto-oncogene, serine/threonine kinase" P04049 3 12583601-12664125 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, RAS pathway related proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Cardiomyopathy, Deafness, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 175.1" "Lineage enriched" "Detected in all" 5 "granulocytes: 175.1" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002639, HPA002640, CAB019291" Approved Supported "Plasma membrane,Cytosol" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 59: Non-specific - Translation" "Cluster 28: BEWO - Transcription regulation" "Cluster 40: Granulosa cells - Unknown function" "Plasma membrane, Cytosol" "CAB019291: , HPA002639: , HPA002640: AB_1856047" "unprognostic (6.33e-2)" "unprognostic (1.29e-1)" "unprognostic (5.92e-2)" "unprognostic (2.17e-3)" "unprognostic (6.51e-3)" "unprognostic (7.66e-3)" "unprognostic (2.66e-3)" "unprognostic (1.53e-2)" "unprognostic (2.72e-1)" "unprognostic (7.66e-2)" "unprognostic (2.92e-2)" "unprognostic (1.29e-2)" "unprognostic (2.79e-2)" "unprognostic (1.79e-1)" "unprognostic (1.27e-1)" "unprognostic (2.64e-2)" "unprognostic (2.36e-2)" 42.4 34.2 36.7 33.8 37.9 77.4 39.2 42.6 37.4 47.6 40.4 46.8 40.5 45.6 34.0 55.5 43.2 31.0 89.6 36.9 35.8 46.7 68.9 44.7 36.3 38.3 36.9 52.0 50.6 63.6 28.3 39.1 37.0 41.9 42.0 37.4 39.6 38.0 194.9 56.0 43.4 45.5 36.7 48.3 55.5 26.8 38.1 52.8 48.8 122.5 47.7 46.1 46.2 39.8 49.9 57.9 85.5 66.6 74.3 59.6 168.0 73.9 129.1 100.1 112.5 46.6 41.3 52.7 34.6 120.1 51.6 31.9 93.4 67.5 103.8 91.4 70.2 72.0 69.4 42.9 74.2 70.1 64.7 55.3 67.8 102.3 82.0 67.6 73.1 78.2 52.6 136.0 98.3 88.6 91.1 47.8 86.5 64.0 76.4 72.6 75.7 66.4 60.9 76.9 26.1 56.2 61.1 59.8 40.9 66.1 99.1 91.5 51.1 65.6 62.5 55.7 85.0 103.3 178.4 112.3 57.2 80.4 73.9 40.4 32.7 62.5 22.3 32.6 22.5 19.5 21.9 22.3 30.3 20.4 21.9 22.8 175.1 29.8 34.2 13.5 28.3 28.2 36.7 37.9 42.6 37.4 36.9 35.8 38.3 36.9 37.0 36.7 38.1 39.8 28.5 22.4 37.6 47.7 36.1 34.4 35.2 22.1 27.9 56.7 27.5 22.6 29.0 35.8 25.7 27.6 66.7 40.0 41.5 31.3 13.7 25.6 8.8 33.2 37.1 32.7 29.3 46.7 46.1 37.0 46.8 32.3 27.5 43.8 34.2 78.7 36.0 41.2 28.6 43.7 52.9 31.0 30.5 39.3 43.4 4.6 39.1 34.7 26.6 44.0 49.5 31.9 51.5 65.4 64.0 35.5 29.9 41.3 43.3 46.9 47.3 20.1 31.2 81.9 32.9 56.2 39.1 28.3 33.6 31.8 43.5 62.3 40.8 35.6 31.2 47.1 RAG1 "MGC43321, RNF74" ENSG00000166349 "Recombination activating 1" P15918 11 36510709-36593156 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "DNA recombination, Ubl conjugation pathway" "Chromatin regulator, DNA-binding, Endonuclease, Hydrolase, Multifunctional enzyme, Nuclease, Transferase" "Disease variant, SCID" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 92 "lymphoid tissue: 395.0" "Cell type enhanced" "Detected in some" "Distal tubular cells: 3.9;Hepatic stellate cells: 8.2" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "MOLT-4: 283.5;REH: 266.4" "Not detected" "Not detected" "Low region specificity" "Detected in some" HPA043939 Supported Nucleoplasm NA NA "Cluster 63: T-cells - Adaptive immune response" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "HPA043939: AB_2732512" "unprognostic (7.35e-2)" "unprognostic (1.57e-3)" "unprognostic (8.75e-2)" "unprognostic (3.44e-1)" "unprognostic (2.14e-1)" "unprognostic (1.46e-2)" "unprognostic (2.30e-1)" "unprognostic (1.70e-2)" "unprognostic (1.43e-1)" "unprognostic (1.54e-2)" "unprognostic (5.98e-3)" "unprognostic (1.28e-1)" "unprognostic (1.16e-9)" "unprognostic (2.16e-2)" "unprognostic (1.04e-1)" "unprognostic (2.53e-4)" "unprognostic (1.53e-1)" 0.4 0.5 0.1 0.2 0.1 4.3 0.2 0.1 0.2 0.4 0.2 0.4 0.8 0.2 0.8 0.1 0.3 0.4 0.3 0.1 0.1 1.3 0.8 0.6 0.1 0.1 0.1 0.3 0.3 0.6 0.1 0.6 0.1 0.3 0.3 0.6 0.4 0.3 0.1 0.1 1.0 0.1 0.1 2.6 0.5 0.3 0.1 395.0 2.4 0.3 0.6 0.3 0.1 0.1 0.4 0.0 0.5 0.1 0.2 0.6 0.0 0.3 0.3 0.1 0.5 0.0 0.4 0.5 0.0 0.0 0.1 0.2 0.0 0.4 0.4 0.1 0.0 0.2 0.0 0.0 0.1 0.0 0.1 0.3 0.4 0.0 0.3 0.2 0.5 54.0 0.2 0.0 0.5 0.0 283.5 0.0 2.2 0.2 0.0 266.4 0.0 1.3 0.9 0.0 0.1 0.3 0.1 0.7 0.1 1.2 1.0 0.1 1.0 0.2 0.2 0.2 0.1 2.3 1.9 0.0 0.0 0.2 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 1.5 0.0 0.0 0.0 0.1 0.1 1.4 0.7 0.0 1.0 1.0 0.8 0.9 0.0 0.4 1.8 0.0 0.2 0.5 1.3 3.9 0.8 2.3 0.3 0.3 1.6 0.0 0.4 1.8 0.5 0.1 0.7 0.0 0.4 0.0 0.3 8.2 2.1 0.4 0.0 1.7 0.8 0.0 0.6 0.7 1.7 0.0 0.1 0.0 1.0 1.1 0.5 2.1 1.0 1.3 1.1 0.4 0.0 0.0 0.5 3.0 2.9 0.4 0.9 0.0 0.2 0.7 1.0 1.0 0.2 0.4 0.4 0.4 0.5 0.6 0.6 RBBP6 "P2P-R, PACT, SNAMA" ENSG00000122257 "RB binding protein 6, ubiquitin ligase" Q7Z6E9 16 24537693-24572863 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA replication, Host-virus interaction, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 143.6" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB032866, HPA041725, HPA043544" Approved Enhanced "Nuclear speckles" NA NA "Cluster 11: Basophils - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" "Nuclear speckles" "CAB032866: AB_2177791, HPA041725: AB_2677639, HPA043544: AB_2678543" "unprognostic (1.04e-1)" "unprognostic (5.08e-2)" "unprognostic (3.35e-1)" "unprognostic (3.85e-2)" "unprognostic (1.97e-2)" "unprognostic (2.15e-2)" "unprognostic (1.08e-2)" "unprognostic (6.60e-2)" "unprognostic (2.70e-3)" "unprognostic (1.29e-2)" "unprognostic (1.77e-1)" "unprognostic (2.01e-2)" "unprognostic (1.21e-2)" "unprognostic (1.44e-1)" "unprognostic (1.01e-1)" "unprognostic (1.22e-1)" "unprognostic (2.83e-2)" 27.1 25.0 22.9 21.1 23.8 143.6 25.9 33.1 29.9 27.8 21.7 31.5 15.0 33.6 26.3 23.2 32.4 25.5 23.9 22.8 23.5 24.3 26.8 27.9 29.7 24.2 22.8 38.8 22.2 21.8 28.1 31.7 24.4 26.0 20.4 51.1 21.4 19.9 29.7 34.6 26.0 24.1 23.9 29.4 25.6 45.5 24.4 26.6 27.2 25.7 23.5 25.3 24.7 27.7 35.4 18.4 42.5 44.4 31.9 32.9 45.9 28.1 26.1 25.1 27.3 20.5 28.3 49.6 20.3 24.4 28.7 33.3 46.2 24.8 41.9 26.9 35.7 41.9 57.1 58.6 24.7 57.5 23.7 28.8 33.7 33.2 38.9 28.6 36.9 42.2 54.5 43.8 29.7 36.5 45.5 51.2 48.7 24.0 17.3 62.8 42.5 43.3 24.7 31.7 33.4 28.5 39.7 35.1 52.3 47.0 27.4 49.7 32.3 31.0 22.8 27.0 30.8 37.7 40.9 60.9 25.1 36.5 26.1 7.1 1.2 2.0 2.0 2.0 2.2 2.0 2.1 1.5 0.9 1.7 1.8 2.0 2.5 3.5 1.1 3.7 1.7 0.6 22.9 23.8 33.1 29.9 22.8 23.5 24.2 22.8 24.4 23.9 24.4 27.7 139.1 86.6 115.3 47.3 125.7 100.7 103.5 40.8 223.1 67.1 145.6 160.8 147.0 44.3 56.5 27.6 100.1 46.3 88.9 71.5 25.4 48.8 307.5 109.8 123.7 93.7 82.0 83.1 52.5 47.6 57.6 127.1 121.8 203.1 51.3 127.8 64.2 59.5 38.4 62.2 53.4 76.0 28.5 53.5 70.2 41.9 72.4 101.5 62.2 54.4 54.0 53.1 52.5 61.3 58.7 56.4 32.8 58.6 173.7 99.9 54.5 23.9 52.0 61.4 52.6 247.0 112.9 100.3 45.8 161.0 101.7 101.5 110.2 105.3 69.3 111.9 RBCK1 "C20orf18, HOIL1, RBCK2, RNF54, UBCE7IP3, XAP4, ZRANB4" ENSG00000125826 "RANBP2-type and C3HC4-type zinc finger containing 1" Q9BYM8 20 407498-432139 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Host-virus interaction, Ubl conjugation pathway" Transferase "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "hTCEpi: 255.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 18: Non-specific - Mitochondria" "Cluster 30: Epithelial cell lines - Translation" "Cluster 53: Intestinal epithelial cells - Unknown function" "unprognostic (1.94e-2)" "unprognostic (2.50e-1)" "unprognostic (1.62e-2)" "unprognostic (2.07e-2)" "unprognostic (2.61e-1)" "unprognostic (1.92e-1)" "unprognostic (1.54e-3)" "unprognostic (1.15e-2)" "unprognostic (7.89e-2)" "unprognostic (3.44e-1)" "unprognostic (1.22e-1)" "unprognostic (2.63e-2)" "prognostic unfavorable (7.41e-9)" "unprognostic (5.87e-2)" "unprognostic (3.64e-2)" "unprognostic (3.33e-2)" "unprognostic (2.39e-3)" 41.3 68.6 20.4 28.8 23.3 25.7 38.6 26.6 32.3 48.5 16.9 50.2 34.6 47.0 13.9 55.0 44.7 19.4 41.3 20.2 20.8 52.5 108.9 47.7 28.1 27.9 22.1 53.5 55.3 30.1 64.1 22.8 23.9 56.0 17.7 12.2 41.9 26.3 38.6 43.0 56.8 19.2 20.3 66.2 50.3 34.8 22.0 43.7 46.7 18.2 18.0 45.6 46.8 27.6 64.0 88.4 21.9 37.2 44.3 54.7 44.9 34.2 55.0 56.2 73.4 53.7 74.1 29.2 51.3 70.7 103.5 62.7 29.4 151.0 19.0 21.7 29.8 30.2 23.9 140.9 185.3 28.4 21.5 83.1 255.7 43.0 173.2 68.2 50.8 109.8 29.6 55.0 40.7 33.2 61.5 69.9 18.4 77.4 73.0 40.3 21.8 37.3 72.7 57.5 41.3 35.9 24.1 122.4 140.7 25.0 73.3 64.2 31.0 54.5 27.0 33.2 46.5 44.4 61.6 35.6 24.5 61.4 39.0 56.5 48.8 85.4 61.9 71.3 43.5 48.1 48.0 63.1 43.6 46.8 38.7 45.2 135.6 52.4 83.9 72.1 55.7 52.7 20.4 23.3 26.6 32.3 20.2 20.8 27.9 22.1 23.9 20.3 22.0 27.6 69.4 32.1 39.8 40.8 54.4 44.5 77.1 96.2 49.5 15.3 65.4 66.7 19.9 64.3 48.2 57.0 16.7 88.7 72.6 111.4 62.6 111.7 58.9 40.4 45.3 59.3 61.7 43.8 15.8 116.2 102.4 52.3 50.0 54.3 43.8 62.9 57.1 139.3 66.8 16.8 17.8 122.8 46.8 69.8 44.2 163.3 65.9 57.2 42.7 23.4 69.1 45.1 106.1 22.1 24.3 108.5 161.0 47.8 30.5 98.8 185.2 74.5 39.0 29.0 46.0 56.9 51.9 32.6 29.3 69.0 40.2 94.7 71.0 110.6 74.2 120.3 RBKS "DKFZp686G13268, RBSK" ENSG00000171174 Ribokinase Q9H477 2 27781379-27890681 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Carbohydrate metabolism" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 46.5" "Cell type enhanced" "Detected in many" "Proximal enterocytes: 79.0;Proximal tubular cells: 110.9;Respiratory ciliated cells: 59.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "EFO-21: 17.8;RPTEC TERT1: 40.8;U-266/84: 18.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019725, HPA028285" Enhanced Approved Nucleoplasm,Cytosol No No 11000 "Cluster 22: NK-cells - Unknown function" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Cytosol Nucleoplasm "HPA019725: AB_1856105, HPA028285: AB_10601480" "unprognostic (1.25e-1)" "unprognostic (2.16e-1)" "unprognostic (2.51e-2)" "unprognostic (5.54e-3)" "unprognostic (4.15e-3)" "unprognostic (2.44e-1)" "unprognostic (1.43e-2)" "unprognostic (4.77e-2)" "unprognostic (2.45e-1)" "unprognostic (5.35e-2)" "unprognostic (1.46e-1)" "unprognostic (3.98e-1)" "unprognostic (1.20e-1)" "unprognostic (1.19e-1)" "unprognostic (1.72e-1)" "unprognostic (1.74e-1)" "unprognostic (9.27e-2)" 5.8 24.8 3.9 2.0 4.3 1.8 3.9 5.2 5.1 3.5 5.0 6.1 25.2 2.8 10.9 3.1 15.5 2.7 5.2 4.1 4.4 27.5 46.5 3.1 1.7 4.4 4.6 8.1 4.6 9.3 11.0 1.8 4.3 2.4 5.2 13.8 2.1 3.4 8.2 1.5 25.6 2.2 3.9 1.7 2.8 9.2 3.9 3.1 9.8 5.9 2.2 2.2 2.3 4.4 6.4 4.9 0.5 0.6 0.4 1.7 3.9 1.3 1.7 1.5 1.1 9.3 2.9 2.4 17.8 3.6 3.0 2.3 0.6 2.7 2.1 0.9 0.3 0.1 0.7 8.2 2.7 1.7 0.2 2.4 3.3 5.8 7.8 1.5 1.2 3.8 0.5 4.0 3.6 8.2 1.5 4.6 0.8 4.6 4.3 1.8 0.3 1.4 40.8 0.5 1.7 2.5 6.1 7.7 2.8 2.3 3.9 9.3 0.2 1.2 0.9 4.3 2.7 13.6 18.2 3.8 3.6 5.6 0.2 1.6 2.5 1.4 1.9 0.9 4.2 4.4 2.7 4.8 3.5 3.7 3.1 2.3 1.0 4.5 0.2 0.4 4.2 2.3 3.9 4.3 5.2 5.1 4.1 4.4 4.4 4.6 4.3 3.9 3.9 4.4 9.9 6.4 5.0 14.7 24.0 2.0 3.1 11.7 26.7 10.7 5.1 7.1 7.1 5.7 9.7 18.4 4.2 4.2 10.5 12.2 46.9 12.6 36.9 35.2 2.4 7.8 3.6 3.0 13.9 12.3 1.3 10.9 8.6 7.4 2.5 4.6 2.9 29.5 6.5 8.4 18.3 4.7 6.1 4.4 3.4 26.4 1.5 50.8 1.8 2.8 2.4 15.5 3.1 15.6 10.3 7.0 14.9 2.6 21.2 1.0 79.0 110.9 59.0 25.6 0.0 3.3 11.2 23.8 20.0 5.2 1.6 1.5 19.6 9.5 10.7 1.9 RBX1 "BA554C12.1, RNF75, ROC1" ENSG00000100387 "Ring-box 1" P62877 22 40951347-40973309 "Enzymes, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Host-virus interaction, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003038 Supported Nucleoplasm NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 21: OE19 - Mitochondria" "Cluster 6: Erythroid cells - Oxygen transport" Nucleoplasm "HPA003038: AB_1079827" "unprognostic (2.34e-1)" "unprognostic (1.54e-2)" "unprognostic (1.31e-1)" "unprognostic (1.60e-3)" "unprognostic (2.30e-1)" "unprognostic (2.92e-2)" "unprognostic (1.82e-3)" "unprognostic (1.74e-1)" "unprognostic (6.61e-2)" "prognostic favorable (6.63e-4)" "unprognostic (5.01e-3)" "unprognostic (2.19e-1)" "unprognostic (4.99e-3)" "unprognostic (2.22e-2)" "unprognostic (1.34e-1)" "unprognostic (4.57e-2)" "unprognostic (3.05e-2)" 37.8 46.8 82.3 33.4 85.6 63.4 45.1 88.4 105.1 38.5 79.7 36.6 26.3 34.3 59.2 53.5 31.4 22.3 72.7 82.9 86.5 49.4 38.9 37.5 44.5 88.2 84.1 26.9 24.7 38.3 34.5 40.9 87.3 32.8 32.8 45.3 33.1 26.9 83.2 43.3 33.1 32.7 89.7 39.8 37.5 24.8 84.1 59.3 35.8 100.5 51.6 36.4 37.7 93.6 111.1 62.2 114.4 57.9 79.9 94.9 64.3 86.6 80.0 128.2 112.9 101.4 52.5 96.7 57.3 86.3 50.8 62.3 110.6 100.2 135.1 113.9 174.7 60.4 84.0 126.1 68.2 148.3 74.8 79.1 79.1 93.0 66.6 73.3 110.5 57.8 72.2 95.6 115.1 136.7 90.2 170.1 63.7 216.3 64.8 116.8 80.0 122.5 149.3 71.0 54.1 34.9 76.5 76.3 82.7 63.8 65.8 99.5 74.8 77.9 81.1 66.4 84.5 80.0 78.9 146.5 98.0 74.7 88.6 151.8 128.1 108.7 79.9 133.9 76.0 114.7 99.2 85.7 129.7 102.4 85.5 93.8 42.3 89.2 154.6 211.1 137.6 250.2 82.3 85.6 88.4 105.1 82.9 86.5 88.2 84.1 87.3 89.7 84.1 93.6 224.9 230.8 144.8 23.5 173.6 300.9 207.2 567.7 129.1 90.4 189.6 237.9 515.4 171.6 300.0 224.3 25.0 507.3 238.6 181.8 508.7 346.8 41.1 227.4 170.6 222.1 162.1 638.3 29.9 333.6 637.9 211.2 107.6 180.4 129.8 140.0 167.4 254.8 431.3 89.2 29.7 205.1 349.9 236.7 334.2 79.4 185.8 270.7 341.5 15.0 532.3 264.5 228.6 18.6 49.6 377.7 229.8 177.1 180.8 269.5 300.5 586.5 314.3 163.7 118.3 160.0 256.3 220.2 242.9 237.5 370.7 675.9 175.3 185.7 207.1 248.8 RC3H1 "KIAA2025, RNF198, roquin, RP5-1198E17.5" ENSG00000135870 "Ring finger and CCCH-type domains 1" Q5TC82 1 173931084-174022357 "Enzymes, Predicted intracellular proteins" "RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027428, HPA027434, HPA027448" Approved Supported "Golgi apparatus,Plasma membrane,Cytosol" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 1: K-562 - Erythropoiesis" "Cluster 44: Endometrium - Transcription" Cytosol "Golgi apparatus, Plasma membrane" "HPA027428: AB_10600324, HPA027434: AB_10601235, HPA027448: AB_10601683" "unprognostic (6.91e-2)" "unprognostic (7.76e-2)" "unprognostic (2.23e-2)" "unprognostic (2.33e-2)" "unprognostic (7.73e-2)" "unprognostic (1.61e-2)" "unprognostic (5.74e-2)" "unprognostic (1.99e-2)" "unprognostic (1.75e-1)" "unprognostic (1.13e-2)" "unprognostic (2.04e-2)" "unprognostic (1.90e-2)" "prognostic unfavorable (7.96e-4)" "unprognostic (5.25e-2)" "unprognostic (2.15e-1)" "unprognostic (3.43e-3)" "unprognostic (6.83e-3)" 4.8 3.8 2.6 4.2 4.7 19.6 5.2 16.0 5.1 4.9 11.4 5.2 3.4 4.5 4.0 6.1 4.8 4.0 4.6 3.1 5.8 3.9 5.8 5.9 4.9 3.5 3.5 5.1 4.8 3.9 4.6 4.3 4.0 4.2 4.2 8.0 4.4 3.5 10.6 7.4 5.5 3.7 2.0 6.7 4.6 5.3 4.1 5.0 5.0 10.3 5.6 4.5 5.1 7.2 6.6 9.1 4.9 7.7 9.2 7.1 6.8 4.4 6.3 5.0 4.4 8.4 7.3 9.4 7.7 7.2 3.9 6.2 7.5 6.3 7.0 6.6 1.8 8.1 6.8 7.0 5.6 10.7 9.1 6.8 4.8 7.3 4.9 4.6 7.9 4.5 9.4 5.6 6.2 5.0 6.5 9.6 8.5 6.1 1.0 7.0 8.8 6.9 8.9 12.7 5.9 5.3 8.4 10.7 4.3 8.2 7.2 10.7 11.4 6.5 6.5 5.6 5.8 6.9 7.5 11.8 4.4 4.8 6.7 3.4 1.9 2.7 1.1 1.9 1.2 1.5 1.1 1.3 1.0 1.8 1.5 1.3 6.4 1.4 2.6 0.8 0.9 0.7 2.6 4.7 16.0 5.1 3.1 5.8 3.5 3.5 4.0 2.0 4.1 7.2 39.8 41.7 34.5 32.0 49.4 34.4 17.3 14.1 60.9 35.6 53.6 28.3 25.7 25.8 20.0 23.9 81.3 10.6 70.2 37.4 9.8 25.4 13.3 77.5 45.9 32.0 34.2 30.7 46.8 18.9 8.2 34.9 68.8 82.9 15.8 20.3 34.2 36.3 11.5 38.7 43.5 28.9 16.2 37.2 48.2 8.1 15.8 38.5 30.2 40.3 33.0 22.7 30.9 42.3 68.2 24.8 22.1 10.5 52.2 38.3 25.1 9.8 30.2 47.3 19.7 39.0 31.5 35.8 14.0 66.8 40.9 11.6 41.4 16.1 25.9 38.5 RC3H2 "FLJ20301, FLJ20713, MNAB, RNF164" ENSG00000056586 "Ring finger and CCCH-type domains 2" Q9HBD1 9 122844556-122905359 "Enzymes, Predicted intracellular proteins, Transcription factors" "Ubl conjugation pathway" "Repressor, RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA042863, HPA062144" Approved Enhanced Vesicles NA NA "Cluster 46: Basophils - DNA binding" "Cluster 34: Non-specific - Transcription" "Cluster 20: HeLa - Mitochondria" "Cluster 44: Endometrium - Transcription" Vesicles "HPA042863: AB_2678204, HPA062144: AB_2732677" "unprognostic (6.05e-2)" "unprognostic (7.87e-2)" "unprognostic (7.24e-2)" "unprognostic (1.66e-1)" "unprognostic (4.08e-3)" "unprognostic (2.37e-1)" "unprognostic (2.43e-2)" "unprognostic (3.92e-2)" "unprognostic (1.99e-1)" "unprognostic (1.57e-1)" "unprognostic (1.80e-1)" "unprognostic (1.21e-1)" "prognostic favorable (5.50e-4)" "unprognostic (1.36e-1)" "unprognostic (1.68e-1)" "unprognostic (2.16e-1)" "unprognostic (1.26e-1)" 11.9 8.9 8.8 12.1 10.8 32.5 10.4 14.0 10.0 13.5 4.4 10.4 9.9 11.9 8.1 13.0 9.7 11.0 13.8 10.9 7.9 12.7 13.4 11.5 18.5 7.1 7.4 11.2 6.8 15.8 9.6 14.6 7.6 9.7 11.2 16.0 9.0 9.1 11.8 10.0 9.4 13.9 7.1 14.1 11.8 11.6 8.0 18.8 12.9 15.3 17.2 14.4 9.0 10.5 17.3 26.2 33.5 18.2 17.4 19.8 17.8 22.0 24.4 25.2 21.8 31.2 18.8 28.8 16.7 29.8 30.1 40.9 35.4 25.1 27.7 13.4 13.5 16.4 44.4 21.3 23.1 19.9 26.5 19.9 25.5 24.3 34.6 22.0 35.6 25.4 24.1 21.6 32.9 23.9 20.2 14.7 17.7 24.9 21.8 19.7 54.8 19.4 25.8 13.9 38.3 25.8 39.2 24.9 21.2 22.8 29.2 17.2 33.9 20.5 17.3 27.7 39.8 14.0 25.4 32.1 22.3 18.2 23.1 10.0 4.6 6.0 6.1 7.3 5.1 4.3 4.8 6.0 4.1 5.8 4.5 4.5 8.0 4.0 6.7 6.5 5.1 2.8 8.8 10.8 14.0 10.0 10.9 7.9 7.1 7.4 7.6 7.1 8.0 10.5 33.8 41.7 32.8 20.9 27.7 11.0 13.6 20.0 20.5 19.2 15.6 10.5 34.8 12.8 17.3 9.2 37.5 15.7 26.6 18.9 3.9 12.0 5.9 27.6 30.9 28.3 23.3 22.7 38.4 11.4 15.2 18.4 23.9 40.1 17.1 21.9 29.6 19.5 9.6 28.6 35.1 19.8 12.2 27.4 19.4 9.5 13.4 21.4 14.2 30.9 26.1 16.9 24.7 35.2 39.3 23.5 9.0 18.0 22.5 24.3 14.8 12.0 17.7 20.2 19.7 16.3 24.1 30.7 17.9 23.3 14.8 23.0 28.8 15.4 14.7 27.3 RCHY1 "ARNIP, CHIMP, DKFZp586C1620, PIRH2, PRO1996, RNF199, ZCHY, ZNF363" ENSG00000163743 "Ring finger and CHY zinc finger domain containing 1" Q96PM5 4 75479037-75514764 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030338, HPA030339" Approved Supported Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" Cytosol "Nucleoplasm, Vesicles" "HPA030338: , HPA030339: AB_10603232" "unprognostic (1.53e-1)" "unprognostic (1.57e-1)" "prognostic favorable (9.09e-4)" "unprognostic (1.90e-1)" "unprognostic (3.45e-3)" "unprognostic (1.19e-2)" "unprognostic (7.87e-3)" "unprognostic (5.82e-2)" "unprognostic (1.96e-1)" "unprognostic (1.98e-1)" "unprognostic (7.45e-3)" "unprognostic (4.60e-2)" "prognostic favorable (3.62e-5)" "unprognostic (1.69e-1)" "unprognostic (2.07e-1)" "unprognostic (1.83e-1)" "prognostic favorable (7.89e-5)" 8.6 7.0 9.5 7.9 10.2 17.0 16.8 12.6 13.0 9.0 7.7 12.1 8.7 9.6 6.9 7.2 11.9 6.8 16.8 9.4 10.6 16.2 12.3 10.0 9.5 8.9 10.4 14.5 8.3 12.6 5.8 10.0 9.9 10.9 13.2 14.8 12.9 10.1 16.5 5.6 8.6 11.6 9.9 11.5 8.9 13.6 10.7 12.7 18.9 23.6 12.6 7.6 4.7 10.7 9.8 5.0 14.6 13.8 15.1 13.1 8.4 6.5 15.1 13.2 15.4 13.8 11.9 16.2 12.0 9.4 13.1 5.8 37.6 11.5 19.9 13.4 12.3 21.2 9.2 17.9 13.0 28.9 11.2 12.2 14.1 15.2 14.2 15.9 27.0 20.8 19.9 16.2 30.9 15.8 26.7 11.5 24.5 26.9 8.7 14.2 34.4 13.9 20.4 16.7 22.6 12.4 10.7 24.8 28.2 15.9 14.0 12.9 10.8 8.6 8.5 7.8 11.1 17.0 13.0 22.8 10.5 20.2 14.0 27.5 9.2 9.7 4.3 5.7 7.6 4.6 5.4 5.2 8.0 2.1 3.9 5.5 4.0 5.5 5.6 4.1 5.7 4.7 9.5 10.2 12.6 13.0 9.4 10.6 8.9 10.4 9.9 9.9 10.7 10.7 22.2 19.2 10.3 28.4 25.4 40.7 32.3 47.1 39.3 35.0 38.5 25.9 56.8 24.3 23.5 23.9 20.9 31.6 31.2 21.9 68.4 30.3 37.3 11.9 17.1 22.3 13.8 21.8 31.2 22.5 23.2 24.6 21.9 17.3 5.1 23.8 25.4 23.0 19.0 23.5 32.3 23.4 38.7 37.5 26.8 59.8 22.4 27.4 28.4 22.5 23.9 32.0 24.7 31.7 41.0 26.5 22.6 25.2 19.7 36.6 24.6 69.4 13.5 21.7 32.9 20.9 27.3 72.8 41.7 28.1 31.0 33.8 32.9 35.2 27.6 26.3 RET "CDHF12, CDHR16, HSCR1, MEN2A, MEN2B, MTC1, PTC, RET51" ENSG00000165731 "Ret proto-oncogene" P07949 10 43077064-43130351 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Hirschsprung disease, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "adrenal gland: 20.8;brain: 27.3;parathyroid gland: 31.8" "Group enriched" "Detected in some" 4 "Horizontal cells: 79.1;Ionocytes: 26.4;Skeletal myocytes: 23.1" "Cancer enhanced" "Detected in many" "breast cancer: 11.0" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "MCF7: 74.6;NB-4: 42.2;SH-SY5Y: 329.3;THP-1: 95.9" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 5 "midbrain: 53.3;spinal cord: 19.4" "CAB002581, HPA008356, HPA008495" Approved Supported Approved "Golgi apparatus,Plasma membrane,Cytosol" No NA 2100000 "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 50: Fibroblasts - ECM organization" "Golgi apparatus, Cytosol" "Plasma membrane" "CAB002581: AB_563673, HPA008356: AB_1847232, HPA008495: " "unprognostic (7.94e-2)" "unprognostic (3.68e-2)" "unprognostic (4.49e-1)" "prognostic unfavorable (5.02e-4)" "unprognostic (1.15e-1)" "unprognostic (9.13e-4)" "unprognostic (1.27e-2)" "unprognostic (3.62e-2)" "unprognostic (2.86e-1)" "unprognostic (2.01e-1)" "unprognostic (1.54e-3)" "unprognostic (4.43e-1)" "unprognostic (9.35e-5)" "unprognostic (1.64e-3)" "unprognostic (8.28e-2)" "unprognostic (3.67e-3)" "unprognostic (2.02e-2)" 1.8 20.8 1.0 1.3 0.9 0.4 1.1 5.1 5.6 1.0 0.2 3.4 1.4 0.6 0.3 0.4 0.5 0.6 2.2 0.3 5.5 0.9 3.0 0.4 0.6 14.4 27.3 0.4 1.3 31.8 5.3 0.5 12.0 1.8 1.4 4.7 5.1 2.0 5.9 0.9 1.4 1.0 4.8 0.2 2.2 2.7 7.6 1.6 0.8 3.1 0.2 0.6 1.4 5.8 0.1 0.4 0.1 1.7 0.0 0.0 0.1 0.7 0.2 0.4 0.1 0.0 0.0 0.0 0.1 0.0 0.6 0.0 5.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 7.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 74.6 0.0 42.2 7.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 4.7 329.3 0.1 0.0 0.1 0.5 4.1 95.9 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.9 0.7 0.1 0.0 1.0 0.9 5.1 5.6 0.3 5.5 14.4 27.3 12.0 4.8 7.6 5.8 0.4 0.0 0.5 1.6 0.0 0.3 0.8 0.0 0.0 1.7 6.0 0.5 2.1 0.0 0.0 0.0 0.0 0.0 2.1 0.2 0.0 0.0 1.5 0.0 0.3 1.1 0.0 0.0 4.2 0.2 2.3 6.8 0.0 0.0 1.3 0.5 0.0 1.2 0.1 79.1 8.6 1.9 26.4 0.0 0.6 1.5 0.3 0.5 0.0 1.0 0.0 0.8 0.0 1.0 0.6 0.0 0.0 0.0 0.0 0.9 0.0 0.1 0.8 1.7 0.0 23.1 1.2 1.1 4.7 0.0 0.6 0.0 0.2 0.3 0.2 0.1 REV3L "POLZ, REV3" ENSG00000009413 "REV3 like, DNA directed polymerase zeta catalytic subunit" O60673 6 111299028-111483715 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, DNA replication" "DNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 28.8" "Cell type enhanced" "Detected in all" "Astrocytes: 290.6;Endometrial stromal cells: 610.1;Inhibitory neurons: 360.2;Oligodendrocyte precursor cells: 594.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA064853, HPA069382" Uncertain Approved Nucleoplasm NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 77: Retina - Visual perception" "Cluster 18: U-2197 - ECM organization" "Cluster 36: Stromal cells - Cell proliferation" Nucleoplasm "HPA064853: AB_2685369, HPA069382: AB_2686134" "unprognostic (5.54e-2)" "unprognostic (2.06e-1)" "unprognostic (5.09e-2)" "unprognostic (1.71e-1)" "unprognostic (1.59e-1)" "unprognostic (8.59e-3)" "unprognostic (4.42e-2)" "unprognostic (1.56e-2)" "unprognostic (8.09e-2)" "unprognostic (1.17e-1)" "unprognostic (6.87e-3)" "unprognostic (1.27e-1)" "unprognostic (4.34e-2)" "unprognostic (2.80e-1)" "unprognostic (1.67e-1)" "unprognostic (1.67e-1)" "unprognostic (1.03e-3)" 6.1 3.6 11.2 6.4 9.2 7.2 3.1 28.8 11.9 16.6 11.3 4.8 4.3 10.3 2.3 4.6 6.2 4.9 4.4 7.2 10.0 4.1 3.5 4.4 5.6 3.6 7.9 7.6 4.2 3.2 0.9 6.8 4.4 4.8 3.5 26.2 3.2 5.0 5.0 4.7 3.6 8.0 1.8 4.6 4.5 7.5 8.4 6.0 6.6 12.2 2.5 4.8 1.0 10.7 9.2 6.3 11.4 13.3 35.2 35.0 11.9 13.6 16.7 6.4 9.6 8.1 5.0 17.0 9.3 15.9 12.0 9.4 17.6 5.7 10.7 13.9 10.0 13.9 13.9 13.3 9.1 13.5 6.9 21.0 3.2 12.0 15.4 10.3 10.2 10.0 18.3 13.9 10.8 7.2 16.7 3.6 3.2 3.8 10.2 11.6 12.7 6.6 2.5 7.9 15.7 11.8 17.5 3.2 12.4 8.5 7.1 14.2 13.7 9.6 9.6 47.0 15.4 14.0 17.1 17.6 9.1 10.5 12.4 0.6 0.6 1.2 1.0 0.5 1.6 1.0 0.8 1.0 0.6 1.6 0.5 1.0 1.9 0.4 0.9 0.9 0.7 0.3 11.2 9.2 28.8 11.9 7.2 10.0 3.6 7.9 4.4 1.8 8.4 10.7 133.4 48.1 82.4 290.6 65.7 30.5 19.5 12.8 45.5 117.5 20.2 17.9 34.5 11.5 29.1 20.2 56.3 27.2 35.3 11.8 3.9 17.3 40.0 151.1 610.1 57.4 59.8 27.5 161.7 11.5 11.9 82.7 41.3 107.5 46.9 61.5 21.8 16.0 11.8 35.3 360.2 18.6 10.2 19.9 87.4 16.3 50.4 57.2 21.4 105.9 23.7 59.6 33.0 594.7 190.3 8.5 12.3 39.1 41.3 21.3 18.4 15.9 43.5 57.6 39.5 122.3 62.3 68.5 70.4 26.1 26.9 33.0 46.4 30.3 21.5 8.2 RFFL "CARP-2, CARP2, fring, rififylin, RNF189, RNF34L" ENSG00000092871 "Ring finger and FYVE like domain containing E3 ubiquitin protein ligase" Q8WZ73 17 35005990-35089319 "Enzymes, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 93.8" "Cell type enhanced" "Detected in many" "Late spermatids: 109.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HDLM-2: 119.5;Karpas-707: 112.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008096, HPA017910, HPA019492" Approved Approved Vesicles NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 2: Karpas-707 - Immune response" "Cluster 22: Epithelial cell types - Mixed function" Vesicles "CAB008096: AB_2178607, HPA017910: AB_1856189, HPA019492: AB_1856190" "unprognostic (2.59e-1)" "unprognostic (2.87e-1)" "prognostic favorable (4.92e-4)" "unprognostic (1.24e-1)" "unprognostic (1.44e-1)" "unprognostic (1.79e-1)" "unprognostic (5.73e-3)" "unprognostic (4.34e-3)" "unprognostic (2.31e-1)" "unprognostic (9.26e-3)" "unprognostic (2.39e-1)" "unprognostic (2.63e-1)" "prognostic unfavorable (2.43e-5)" "unprognostic (1.44e-1)" "unprognostic (1.97e-1)" "unprognostic (8.68e-2)" "unprognostic (1.36e-1)" 9.9 7.1 23.9 17.7 59.5 41.4 12.2 49.2 38.0 11.9 11.6 26.7 28.1 9.6 8.8 35.9 9.3 19.4 8.2 24.3 36.4 17.7 48.3 12.6 17.6 74.2 53.0 8.5 18.8 12.1 6.8 11.9 71.2 18.3 23.2 21.1 13.1 12.7 15.8 7.5 22.8 13.3 48.6 19.2 23.3 26.6 52.2 26.0 39.0 13.1 29.4 20.3 16.2 93.8 22.9 43.4 10.7 15.0 21.6 28.1 6.1 15.6 25.8 15.5 18.7 15.4 50.5 7.0 19.4 21.4 33.0 32.2 18.4 30.8 22.4 119.5 11.2 40.5 11.0 38.6 18.0 20.2 20.0 19.0 18.8 23.7 46.9 22.6 15.6 21.2 18.2 112.2 16.0 8.7 4.9 19.4 15.2 51.1 24.9 17.3 18.7 43.2 22.8 48.6 12.0 15.8 8.9 10.3 9.1 24.4 15.9 27.7 29.7 8.6 14.9 8.7 24.1 41.4 33.0 9.4 36.4 15.8 7.4 28.6 16.2 33.7 16.8 9.3 20.6 7.8 18.5 16.3 10.8 6.9 16.0 14.5 55.3 14.4 9.9 1.3 29.6 15.5 23.9 59.5 49.2 38.0 24.3 36.4 74.2 53.0 71.2 48.6 52.2 93.8 6.5 41.7 27.4 0.0 12.6 6.0 11.9 7.4 5.2 10.6 9.9 3.8 1.3 20.0 17.3 0.0 14.6 9.4 12.1 33.7 1.9 8.4 41.0 13.0 6.8 6.6 15.0 23.8 0.0 15.1 1.7 9.3 23.0 18.1 25.3 5.4 9.3 35.2 7.2 6.7 0.0 26.4 6.1 16.3 16.9 109.1 3.1 16.1 1.8 0.0 22.6 20.8 25.7 0.0 0.0 16.8 19.3 4.5 12.9 28.1 16.7 20.4 11.7 34.9 6.6 15.2 5.7 15.9 10.8 16.2 6.1 5.1 23.7 3.1 18.9 39.5 RFK "FLJ11149, RIFK" ENSG00000135002 "Riboflavin kinase" Q969G6 9 76385526-76394517 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 352.0;Pancreatic endocrine cells: 220.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA023259, CAB033887, HPA057163" Approved Approved "Golgi apparatus" NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 45: Intestine - Brush border" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 53: Intestinal epithelial cells - Unknown function" "Golgi apparatus" "CAB033887: AB_2178617, HPA023259: AB_2671127, HPA057163: AB_2683357" "unprognostic (1.79e-1)" "unprognostic (3.98e-2)" "unprognostic (1.83e-1)" "unprognostic (1.03e-1)" "unprognostic (1.34e-1)" "unprognostic (1.76e-3)" "unprognostic (8.61e-3)" "unprognostic (3.11e-1)" "unprognostic (1.39e-1)" "unprognostic (2.88e-1)" "unprognostic (1.02e-1)" "unprognostic (4.61e-2)" "unprognostic (1.22e-3)" "unprognostic (3.22e-2)" "unprognostic (1.83e-1)" "unprognostic (2.70e-1)" "unprognostic (3.88e-2)" 11.6 20.6 18.0 14.6 18.4 25.0 11.7 12.6 21.1 11.7 12.5 30.8 33.1 12.8 18.2 12.9 13.6 19.9 16.3 20.6 27.2 27.0 29.2 12.4 11.6 16.9 18.4 11.7 16.4 23.8 12.0 13.2 27.0 13.0 22.9 14.7 11.0 9.9 14.9 5.1 28.2 11.9 14.2 10.2 29.0 16.7 21.6 12.0 19.7 18.7 11.2 13.9 5.9 13.5 21.9 23.2 13.9 18.1 20.5 20.3 41.8 25.2 18.6 17.8 13.9 8.2 13.3 35.3 28.7 18.2 32.3 22.9 19.3 16.5 35.3 10.4 18.0 11.2 30.4 26.2 36.7 37.9 25.6 13.5 29.3 21.4 23.2 19.9 58.3 30.4 30.6 28.7 36.1 20.8 49.3 13.3 18.1 51.2 22.7 26.7 18.3 8.9 82.0 10.6 35.0 12.7 26.9 37.2 22.9 18.1 9.4 20.2 35.9 18.5 33.3 40.1 35.6 30.7 32.3 12.4 30.7 33.3 25.9 5.2 9.8 3.6 5.0 19.9 7.5 5.8 7.3 6.0 11.8 4.4 7.0 6.7 1.4 8.5 21.1 4.3 7.4 9.8 18.0 18.4 12.6 21.1 20.6 27.2 16.9 18.4 27.0 14.2 21.6 13.5 27.3 16.0 9.2 5.9 22.9 45.4 23.8 15.3 22.2 50.4 24.5 20.6 37.9 34.3 20.1 42.3 20.9 54.1 18.4 158.8 60.7 64.9 191.7 37.8 18.5 46.2 28.2 48.8 18.0 189.3 352.0 33.5 33.1 42.3 12.0 18.0 124.2 40.9 33.2 11.8 19.3 23.1 40.7 57.6 26.6 118.1 22.1 29.9 30.2 10.3 25.2 44.7 9.2 7.1 6.5 220.6 68.3 65.1 12.7 33.6 79.9 142.8 27.7 28.7 0.0 23.0 21.7 91.8 64.1 18.8 40.5 123.5 23.1 18.8 33.7 22.6 RFNG ENSG00000169733 "RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase" Q9Y644 17 82047902-82051831 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Differentiation, Neurogenesis" "Developmental protein, Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "HHSteC: 69.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA011564, HPA031673" Uncertain Approved Nucleoplasm No No 1100000 "Cluster 35: T-regs - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 40: Granulosa cells - Unknown function" Nucleoplasm "HPA011564: AB_1079803, HPA031673: AB_2673989" "unprognostic (4.17e-3)" "unprognostic (7.60e-3)" "unprognostic (2.87e-3)" "unprognostic (2.49e-1)" "unprognostic (2.05e-1)" "unprognostic (2.65e-2)" "unprognostic (1.62e-1)" "unprognostic (9.86e-2)" "unprognostic (1.02e-1)" "unprognostic (1.53e-1)" "prognostic favorable (4.81e-4)" "unprognostic (1.20e-1)" "unprognostic (6.96e-3)" "unprognostic (1.77e-1)" "unprognostic (2.16e-1)" "unprognostic (6.93e-2)" "unprognostic (4.14e-2)" 28.3 24.3 9.9 3.8 9.7 10.2 24.6 8.5 11.8 25.5 7.8 26.5 11.1 25.3 1.6 24.1 23.0 10.9 19.5 8.7 9.0 22.9 78.5 18.7 5.4 10.4 9.3 29.7 42.6 11.1 20.0 5.9 9.5 23.5 3.2 1.4 22.0 6.9 45.4 27.1 16.7 7.7 9.0 14.9 27.7 23.2 9.6 4.6 19.8 10.5 2.7 24.0 18.6 9.7 20.3 19.2 5.6 19.1 13.9 11.8 24.4 18.5 10.1 8.2 6.2 11.6 13.7 4.5 13.0 29.1 17.4 10.8 3.9 15.8 1.5 6.0 19.7 6.7 4.4 48.5 69.3 2.4 14.2 22.5 9.9 14.7 24.9 16.5 15.8 15.2 8.5 16.9 6.6 24.1 15.1 6.5 5.5 13.5 20.1 10.2 7.0 10.6 9.5 11.8 9.7 24.9 7.1 10.7 54.7 6.2 32.1 13.7 6.1 13.1 17.9 12.7 10.2 22.9 4.5 5.0 16.8 4.4 11.7 1.0 1.9 2.0 1.7 0.5 0.6 1.0 1.1 1.6 1.4 1.2 1.1 0.6 0.7 0.2 0.7 1.1 2.5 0.6 9.9 9.7 8.5 11.8 8.7 9.0 10.4 9.3 9.5 9.0 9.6 9.7 24.3 6.4 12.4 30.7 7.6 9.7 11.9 8.3 6.8 26.9 33.3 35.4 12.8 18.6 5.6 23.9 25.0 5.5 14.2 20.9 7.9 7.8 3.7 14.9 24.4 12.1 11.4 5.7 20.7 15.1 3.3 27.2 18.8 19.0 1.3 52.5 21.8 47.1 9.6 11.8 20.3 14.0 12.2 15.2 6.3 13.3 21.8 14.7 10.6 16.9 6.2 29.8 3.1 20.6 13.5 12.4 16.3 19.9 4.9 15.9 14.0 31.3 6.8 27.8 0.0 28.0 19.4 14.4 6.2 9.0 10.2 3.7 10.4 32.8 13.5 8.7 RFWD3 "FANCW, FLJ10520, RNF201" ENSG00000168411 "Ring finger and WD repeat domain 3" Q6PCD5 16 74621399-74666877 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Disease variant, Fanconi anemia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 47.7" "Cell type enhanced" "Detected in many" "Spermatocytes: 48.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA048258, HPA075649" Approved Enhanced Nucleoplasm,Cytosol No No "Cluster 42: Non-specific - Transcription" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm Cytosol "HPA048258: AB_2680332, HPA075649: AB_2686761" "unprognostic (4.79e-2)" "unprognostic (6.45e-3)" "unprognostic (6.35e-2)" "unprognostic (6.61e-2)" "unprognostic (2.73e-1)" "unprognostic (1.97e-1)" "unprognostic (1.11e-3)" "unprognostic (5.04e-2)" "unprognostic (3.64e-2)" "unprognostic (1.01e-1)" "unprognostic (4.03e-3)" "unprognostic (2.53e-3)" "unprognostic (1.73e-3)" "unprognostic (2.84e-1)" "unprognostic (4.31e-1)" "unprognostic (5.74e-2)" "unprognostic (3.29e-1)" 5.2 3.9 2.5 9.9 3.5 47.7 7.6 4.0 3.2 6.4 4.4 8.0 6.5 6.2 5.3 9.4 6.8 6.5 2.9 2.3 2.9 6.7 5.8 6.1 15.4 3.3 3.1 7.0 10.2 6.8 3.8 8.0 3.2 4.9 9.3 6.2 5.8 5.1 3.3 12.6 6.1 6.1 2.8 8.1 6.2 25.2 3.4 27.1 6.6 2.7 16.7 7.2 6.8 4.7 46.1 57.5 42.6 31.2 8.8 11.9 47.8 40.5 30.9 63.0 54.5 75.4 46.8 63.6 32.1 31.8 31.6 53.9 70.3 42.1 76.9 20.0 42.1 56.3 46.0 43.0 7.6 57.3 56.3 8.6 13.2 79.6 48.7 16.3 27.3 53.2 86.7 27.7 48.1 72.8 84.0 52.2 84.0 26.8 27.7 128.7 28.8 55.9 22.7 47.8 31.5 33.6 65.2 22.8 28.8 38.2 41.7 48.4 26.7 46.0 43.9 26.2 51.4 37.4 75.1 188.3 32.8 43.5 57.0 12.1 4.4 6.5 5.5 4.1 6.1 4.9 4.5 5.1 4.6 5.4 6.7 4.8 4.9 6.2 7.7 3.5 7.2 4.4 2.5 3.5 4.0 3.2 2.3 2.9 3.3 3.1 3.2 2.8 3.4 4.7 6.0 0.0 5.9 4.2 13.2 10.8 6.8 4.0 10.2 6.6 8.4 8.3 3.9 2.8 5.4 1.8 10.4 12.1 15.3 7.6 11.7 6.2 5.4 6.9 5.7 7.2 9.5 22.5 8.9 7.6 8.3 5.9 5.1 6.6 4.5 13.5 11.7 7.4 8.9 3.3 7.1 9.7 2.0 12.2 6.0 6.3 3.7 7.8 16.0 15.0 7.6 3.0 10.3 6.6 15.2 10.0 2.7 4.1 11.6 12.7 4.3 4.6 5.9 6.7 6.6 6.4 5.6 48.5 31.7 9.5 9.2 7.5 10.6 3.6 9.5 11.4 RING1 RNF1 ENSG00000204227 "Ring finger protein 1" Q06587 6 33208500-33212722 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" "Chromatin regulator, Repressor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008701 Supported Approved Nucleoplasm,Cytosol NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 35: Non-specific - Unknown function" "Cluster 44: HDLM-2 - Immune response" "Cluster 55: Plasma cells - Humoral immune response" Nucleoplasm Cytosol "HPA008701: AB_1079814" "unprognostic (2.12e-3)" "unprognostic (7.98e-2)" "unprognostic (3.77e-2)" "unprognostic (1.37e-1)" "unprognostic (3.91e-2)" "unprognostic (3.21e-1)" "unprognostic (1.53e-1)" "unprognostic (4.75e-2)" "unprognostic (7.76e-2)" "unprognostic (1.26e-2)" "unprognostic (3.70e-2)" "unprognostic (1.62e-2)" "unprognostic (2.22e-1)" "unprognostic (1.04e-1)" "unprognostic (1.55e-1)" "unprognostic (2.13e-1)" "unprognostic (9.88e-2)" 38.6 42.4 39.2 21.6 42.7 18.1 36.8 39.7 45.6 60.2 42.2 45.4 21.3 51.5 20.8 37.4 51.8 19.3 37.0 38.7 41.4 50.7 51.2 39.3 20.9 39.4 42.7 59.4 44.7 34.2 80.8 19.4 40.6 55.8 7.2 15.7 37.0 23.2 37.3 34.7 37.0 29.6 39.9 41.2 37.5 46.9 43.4 34.4 67.1 25.4 17.3 41.3 42.2 47.5 38.8 24.9 38.2 33.3 35.0 13.2 15.5 36.5 55.1 32.7 40.5 35.2 22.9 30.1 19.0 41.2 45.8 21.0 31.6 29.7 24.5 69.5 16.5 60.2 50.4 40.2 75.9 37.7 57.0 0.0 26.7 34.4 53.6 38.1 16.5 30.4 49.2 37.2 37.2 0.0 6.3 22.1 13.6 24.5 17.0 18.1 27.1 59.6 42.9 41.5 43.6 32.4 26.3 34.8 62.9 11.6 40.2 56.7 26.1 37.6 29.7 5.6 43.8 56.4 37.1 32.6 25.5 36.0 28.7 0.0 0.4 1.6 0.0 0.2 0.6 0.8 0.5 0.6 0.4 0.2 0.6 1.3 0.6 0.5 0.5 1.1 0.8 0.4 39.2 42.7 39.7 45.6 38.7 41.4 39.4 42.7 40.6 39.9 43.4 47.5 27.5 0.0 20.2 22.5 23.6 27.5 40.6 28.6 51.2 32.1 26.8 25.3 23.9 21.5 22.1 22.0 16.7 41.9 30.8 23.7 15.6 32.8 34.7 28.4 29.0 26.8 30.6 16.8 23.2 34.7 35.2 32.2 31.6 29.5 19.7 19.7 35.0 36.9 29.1 25.2 23.0 24.1 8.2 26.5 23.5 21.5 40.0 22.3 17.8 12.2 21.0 44.8 21.6 12.5 20.3 31.2 25.1 29.7 32.2 29.4 36.6 34.8 25.9 21.6 26.3 38.3 30.9 33.4 18.9 32.7 30.5 63.1 27.6 32.6 21.8 30.2 RIOK1 "AD034, bA288G3.1, FLJ30006, RRP10" ENSG00000124784 "RIO kinase 1" Q9BRS2 6 7389793-7418037 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ribosome biogenesis" "Hydrolase, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA017866, HPA051446" Enhanced Supported Cytosol NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" Cytosol "HPA017866: AB_2669670, HPA051446: AB_2681488" "unprognostic (2.33e-2)" "unprognostic (1.24e-1)" "unprognostic (2.38e-1)" "unprognostic (1.03e-2)" "unprognostic (1.16e-1)" "unprognostic (1.51e-1)" "prognostic unfavorable (3.41e-5)" "unprognostic (2.23e-1)" "prognostic unfavorable (4.43e-4)" "unprognostic (3.45e-2)" "unprognostic (1.47e-1)" "unprognostic (1.87e-1)" "prognostic unfavorable (5.85e-5)" "unprognostic (2.33e-1)" "unprognostic (2.09e-1)" "unprognostic (6.12e-3)" "unprognostic (2.59e-2)" 12.1 9.3 4.1 10.8 4.1 20.6 11.0 5.0 5.3 10.0 3.7 7.9 6.5 10.5 5.2 11.4 8.2 7.5 8.0 4.2 5.1 6.4 7.9 7.1 14.0 4.7 5.1 10.9 10.2 7.3 4.7 11.4 4.6 8.0 8.6 7.3 7.0 8.1 11.5 9.1 6.3 10.8 4.2 9.4 7.0 19.9 4.5 15.7 7.3 10.3 15.9 14.9 7.6 4.7 20.4 11.7 18.3 45.8 27.0 22.6 28.7 25.6 16.6 22.1 18.5 33.1 10.0 51.8 43.3 19.7 19.4 20.3 45.7 19.5 29.0 35.8 49.6 28.3 18.3 39.4 23.0 81.5 37.5 17.2 27.2 24.1 50.4 11.5 20.1 38.6 72.1 12.3 21.0 26.7 56.8 50.2 39.6 36.3 26.1 42.9 23.3 56.6 13.8 19.9 60.8 30.4 20.8 13.3 41.6 48.4 18.9 28.4 19.9 24.4 18.9 17.5 38.3 17.1 33.0 75.7 7.7 44.0 38.7 12.0 11.5 9.0 14.9 15.6 18.0 21.5 15.4 15.9 20.5 23.0 17.8 19.2 2.3 26.7 14.0 17.3 16.2 11.3 4.1 4.1 5.0 5.3 4.2 5.1 4.7 5.1 4.6 4.2 4.5 4.7 22.2 6.4 26.4 5.5 27.5 52.8 32.3 29.5 38.1 10.0 18.9 22.0 22.8 4.3 35.2 7.3 10.4 34.1 25.3 9.9 3.9 15.9 74.8 14.9 28.4 24.8 7.2 17.9 10.2 11.7 34.7 29.8 16.8 19.1 33.6 13.4 19.2 10.2 22.6 5.0 12.0 17.4 20.3 11.2 25.1 12.5 19.9 19.7 17.8 11.2 15.1 8.9 6.2 13.0 8.4 12.2 8.2 19.9 27.0 33.7 7.1 9.3 20.9 13.7 19.7 33.8 23.9 58.9 75.4 33.7 64.8 27.9 29.0 23.9 16.9 23.8 RIOK2 FLJ11159 ENSG00000058729 "RIO kinase 2" Q9BVS4 5 97160867-97183247 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Ribosome biogenesis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005681 Uncertain Approved "Plasma membrane,Cytosol" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 54: Non-specific - Microtubule organization" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 7: Non-specific - Mitochondria" Cytosol "Plasma membrane" "HPA005681: AB_1856286" "unprognostic (6.36e-2)" "unprognostic (1.21e-1)" "unprognostic (1.13e-2)" "unprognostic (8.04e-2)" "unprognostic (1.38e-1)" "unprognostic (4.51e-2)" "unprognostic (2.71e-3)" "unprognostic (3.08e-1)" "unprognostic (3.90e-2)" "unprognostic (1.11e-1)" "unprognostic (8.76e-2)" "unprognostic (6.63e-2)" "unprognostic (1.26e-3)" "unprognostic (3.60e-1)" "unprognostic (9.98e-2)" "unprognostic (1.43e-2)" "unprognostic (1.39e-2)" 15.0 14.6 12.5 13.5 13.7 21.5 14.7 16.6 21.3 12.9 14.1 13.3 13.0 11.6 12.2 13.5 12.3 7.8 16.3 12.5 14.7 14.2 18.1 10.3 14.3 13.5 13.5 14.8 16.7 11.3 15.1 12.1 13.5 12.0 12.7 19.4 11.8 9.3 21.4 11.3 11.2 9.3 13.9 14.6 13.3 12.6 13.7 13.7 11.9 14.2 13.6 13.2 12.1 15.9 19.0 22.0 20.3 38.5 25.9 28.6 32.1 48.1 29.0 33.0 43.2 30.4 32.5 41.7 53.1 21.3 51.6 21.7 34.2 27.4 44.9 29.3 18.5 20.3 44.0 42.9 23.6 38.5 27.2 18.5 20.8 40.1 39.8 25.0 27.0 30.8 31.7 25.4 38.0 31.9 46.4 47.8 22.5 10.6 23.9 51.9 38.3 61.9 25.7 16.9 23.7 17.9 27.5 28.3 35.6 29.6 29.6 36.4 28.5 41.2 28.9 33.0 51.8 25.3 36.4 95.2 24.0 39.7 38.4 17.9 26.2 15.8 24.6 30.7 34.4 24.0 31.5 27.8 29.4 18.6 33.9 36.5 5.0 30.7 23.8 29.2 31.7 22.7 12.5 13.7 16.6 21.3 12.5 14.7 13.5 13.5 13.5 13.9 13.7 15.9 14.9 9.6 12.8 7.8 16.9 26.4 17.9 25.2 12.5 16.2 11.1 11.4 20.5 10.0 17.4 7.3 12.5 19.6 26.9 6.4 17.6 17.3 1.3 10.7 18.0 14.0 9.6 8.4 10.9 14.9 24.8 21.1 14.8 10.5 27.9 12.7 8.2 8.1 18.3 13.5 11.0 12.7 18.3 9.4 9.2 3.0 13.4 11.0 5.4 3.7 16.5 13.4 14.4 9.0 15.0 11.4 10.1 16.1 19.1 10.4 11.8 17.3 13.3 17.7 6.6 17.4 22.9 23.5 20.7 10.1 18.9 17.4 19.6 19.4 12.6 12.0 RIOK3 SUDD ENSG00000101782 "RIO kinase 3" O14730 18 23453287-23486603 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Antiviral defense, Immunity, Innate immunity, Ribosome biogenesis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 174.3" "Cell type enhanced" "Detected in all" "Distal enterocytes: 338.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001620, HPA024184" Approved Approved "Golgi apparatus,Plasma membrane,Centriolar satellite,Cytosol" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 30: Epithelial cell lines - Translation" "Cluster 53: Intestinal epithelial cells - Unknown function" "Plasma membrane, Cytosol" "Golgi apparatus, Centriolar satellite" "HPA001620: AB_1079815, HPA024184: AB_1856289" "unprognostic (7.99e-2)" "unprognostic (1.71e-2)" "unprognostic (2.39e-1)" "unprognostic (3.03e-2)" "unprognostic (1.05e-1)" "unprognostic (7.48e-2)" "unprognostic (8.98e-3)" "unprognostic (1.01e-1)" "unprognostic (5.10e-2)" "unprognostic (4.20e-1)" "prognostic unfavorable (4.10e-4)" "prognostic unfavorable (5.80e-4)" "unprognostic (3.90e-2)" "unprognostic (1.46e-1)" "unprognostic (5.44e-2)" "unprognostic (1.39e-1)" "unprognostic (2.71e-2)" 23.1 18.5 5.5 20.4 7.1 174.3 19.2 7.9 10.2 17.4 8.3 47.5 51.6 16.7 12.4 65.5 14.8 24.3 32.7 5.9 6.7 29.6 55.6 22.7 22.8 9.3 7.3 15.7 27.6 22.8 5.4 34.9 8.9 20.1 43.5 19.6 23.2 14.5 52.9 33.3 62.5 19.7 7.5 21.5 38.5 36.6 6.9 21.5 22.2 48.8 30.2 25.8 27.0 10.6 41.9 15.7 17.8 25.0 31.8 37.7 28.5 38.9 29.8 27.6 28.4 17.3 47.5 27.6 52.3 43.7 26.9 57.6 25.9 45.4 38.9 29.5 12.0 25.9 26.9 22.2 71.7 74.7 25.8 39.0 91.2 44.1 66.7 36.7 38.4 19.2 39.8 34.7 45.0 19.4 25.8 15.6 17.6 59.0 31.3 31.3 33.2 41.2 39.3 50.0 39.5 28.9 50.1 28.4 37.4 41.0 21.9 45.0 63.7 48.4 10.9 21.2 28.9 66.1 56.0 38.2 31.0 36.7 38.2 50.1 24.5 14.8 15.0 34.6 10.8 14.0 12.3 12.6 19.1 18.5 9.8 11.2 17.2 15.0 39.0 8.6 19.4 20.7 5.5 7.1 7.9 10.2 5.9 6.7 9.3 7.3 8.9 7.5 6.9 10.6 49.7 80.1 57.7 23.2 46.4 120.4 92.4 78.6 113.8 44.1 49.3 35.6 69.1 51.5 81.5 25.8 56.3 43.0 74.6 338.1 25.4 51.0 271.5 130.1 85.5 44.1 62.8 259.8 35.5 52.7 64.6 48.8 93.8 267.2 63.3 40.0 29.6 88.5 41.1 28.6 34.2 119.9 50.8 59.9 51.2 305.8 22.4 85.7 42.7 15.9 80.6 18.3 53.5 34.2 49.5 148.4 210.7 30.1 63.4 118.5 199.5 52.5 72.3 46.4 6.6 43.9 51.6 28.4 10.1 164.2 143.6 88.4 57.3 71.1 77.2 244.4 RIPK1 RIP ENSG00000137275 "Receptor interacting serine/threonine kinase 1" Q13546 6 3063824-3115187 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Host-virus interaction, Inflammatory response, Necrosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010302, HPA015257" Supported Approved "Plasma membrane,Cytosol" NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 18: Non-specific - Mitochondria" "Cluster 44: HDLM-2 - Immune response" "Cluster 7: Non-specific - Mitochondria" "Plasma membrane, Cytosol" "CAB010302: AB_2178118, HPA015257: AB_1856294" "unprognostic (1.24e-1)" "unprognostic (6.83e-2)" "unprognostic (1.87e-1)" "unprognostic (7.75e-2)" "unprognostic (6.08e-2)" "unprognostic (1.01e-2)" "unprognostic (1.26e-2)" "unprognostic (1.96e-1)" "unprognostic (9.46e-2)" "unprognostic (1.46e-1)" "unprognostic (5.00e-2)" "unprognostic (3.29e-1)" "unprognostic (9.65e-3)" "unprognostic (3.44e-1)" "unprognostic (9.01e-2)" "unprognostic (1.38e-2)" "prognostic favorable (6.71e-4)" 18.5 12.0 1.9 9.3 1.9 0.5 16.2 1.8 3.8 12.8 2.4 17.5 12.3 14.5 5.3 17.6 12.8 10.6 11.8 1.8 1.9 13.7 23.6 13.5 10.1 2.2 1.9 8.5 17.4 12.2 12.3 10.9 2.0 13.7 13.0 2.4 16.4 8.9 11.7 20.7 19.9 11.9 2.0 19.4 16.5 5.3 2.0 11.9 14.4 5.0 13.0 15.5 13.7 1.9 14.4 9.8 12.9 12.4 27.6 19.2 5.5 21.4 30.8 22.8 26.7 12.4 8.0 13.8 20.9 30.1 23.2 14.3 17.9 17.2 24.3 27.8 9.4 16.7 4.5 6.9 17.2 15.6 20.1 24.8 15.1 20.4 15.3 17.6 20.6 6.2 19.4 4.6 22.0 17.8 10.7 7.7 8.8 17.4 12.7 11.8 10.9 14.5 17.3 27.2 11.3 12.2 14.7 7.8 22.4 26.0 15.2 8.7 25.1 20.6 12.1 8.2 16.4 9.8 15.3 13.5 8.9 7.0 27.7 0.1 0.4 0.9 0.6 0.9 1.0 0.3 0.9 1.7 1.0 1.2 0.7 0.7 0.0 1.5 0.5 0.5 1.7 0.8 1.9 1.9 1.8 3.8 1.8 1.9 2.2 1.9 2.0 2.0 2.0 1.9 28.6 6.4 12.0 17.3 14.7 11.0 10.3 6.6 16.5 4.4 14.7 17.8 8.6 17.2 16.7 9.2 12.5 8.9 21.9 27.1 5.9 9.4 2.0 10.5 14.0 16.7 6.6 7.2 23.1 12.9 7.7 18.3 27.0 13.4 10.8 8.7 10.0 14.6 11.6 5.0 26.7 17.7 4.1 6.7 11.1 0.8 6.8 15.3 3.6 11.2 13.8 6.6 12.3 14.6 16.2 13.8 11.7 6.0 22.3 11.3 12.7 8.7 17.4 21.4 19.7 32.5 17.9 1.2 2.8 20.5 9.9 11.9 20.8 10.6 11.3 14.5 RIPK2 "CARD3, CARDIAK, RICK, RIP2" ENSG00000104312 "Receptor interacting serine/threonine kinase 2" O43353 8 89757806-89791064 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Adaptive immunity, Apoptosis, Immunity, Innate immunity" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Glandular and luminal cells: 156.1;Langerhans cells: 121.3;Macrophages: 105.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "hTERT-HME1: 49.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015273, HPA016499" Approved Enhanced Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 30: Epithelial cell lines - Translation" "Cluster 41: Macrophages - Immune response" Cytosol "HPA015273: AB_1856299, HPA016499: AB_1856300" "unprognostic (1.20e-1)" "unprognostic (1.02e-2)" "unprognostic (2.35e-1)" "unprognostic (3.82e-2)" "unprognostic (1.67e-1)" "unprognostic (6.20e-2)" "unprognostic (1.43e-3)" "prognostic unfavorable (6.33e-5)" "unprognostic (2.06e-1)" "unprognostic (7.80e-2)" "prognostic unfavorable (5.00e-6)" "unprognostic (6.39e-2)" "prognostic unfavorable (0.00e+0)" "unprognostic (1.84e-2)" "unprognostic (5.08e-2)" "unprognostic (1.05e-2)" "prognostic favorable (8.05e-4)" 4.1 1.6 4.0 5.6 4.0 8.9 5.1 4.0 5.5 4.7 3.3 2.9 1.7 5.5 2.4 3.0 2.7 9.4 4.4 4.1 5.5 3.7 5.6 6.0 6.5 4.6 4.0 2.5 4.4 4.2 1.9 4.7 5.1 5.3 2.9 1.5 5.0 2.7 0.6 4.2 2.4 5.7 5.3 4.8 2.9 2.9 3.7 2.8 4.2 1.3 6.7 9.4 2.6 6.0 17.8 6.0 3.2 4.9 7.9 10.8 5.5 19.2 36.1 10.7 13.6 4.6 9.7 14.4 28.0 11.7 7.6 4.2 8.9 6.9 20.2 8.7 8.0 11.9 2.8 5.5 22.2 4.5 5.8 8.8 5.6 15.6 49.8 11.4 11.4 0.0 5.4 4.7 10.2 3.4 0.0 9.6 1.5 8.4 14.4 3.2 4.1 7.5 26.1 8.4 0.4 3.1 4.7 12.6 10.0 4.0 12.0 5.6 10.1 6.5 6.0 11.2 9.1 8.9 4.2 8.8 16.2 0.4 4.3 13.7 6.6 23.2 3.5 12.5 4.1 7.6 5.4 4.6 8.1 4.8 4.9 5.4 5.1 4.4 14.9 2.6 1.3 4.6 4.0 4.0 4.0 5.5 4.1 5.5 4.6 4.0 5.1 5.3 3.7 6.0 19.3 35.3 18.1 25.5 29.8 57.6 33.7 13.3 16.5 2.1 17.2 8.9 5.2 4.3 22.9 3.7 0.0 13.3 32.8 2.8 5.9 80.1 6.6 82.3 23.7 15.0 0.0 9.9 12.9 60.8 45.7 27.3 9.7 156.1 43.1 7.1 6.1 3.2 41.7 3.3 9.1 5.4 24.4 32.4 121.3 2.5 7.8 105.1 19.6 15.0 42.1 12.1 8.2 15.6 12.8 50.0 2.7 6.0 22.0 59.2 2.2 10.4 11.6 0.3 13.1 19.2 19.6 7.9 12.8 14.7 48.3 83.7 30.4 7.5 8.1 49.5 RIPK3 RIP3 ENSG00000129465 "Receptor interacting serine/threonine kinase 3" Q9Y572 14 24336025-24340022 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Host-virus interaction, Necrosis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Distal enterocytes: 38.5;Exocrine glandular cells: 35.2;Gastric mucus-secreting cells: 22.4;Paneth cells: 21.4;Proximal enterocytes: 22.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in some" "CAPAN-2: 7.0;HDLM-2: 4.1;OE19: 10.1;SK-BR-3: 11.1" "Not detected" "Not detected" "Low region specificity" "Detected in many" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 64: Macrophages - Immune response" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" "unprognostic (1.85e-2)" "unprognostic (1.66e-1)" "unprognostic (5.16e-3)" "unprognostic (1.12e-2)" "unprognostic (1.95e-1)" "unprognostic (1.29e-1)" "unprognostic (1.19e-1)" "unprognostic (2.32e-1)" "unprognostic (3.25e-1)" "unprognostic (2.02e-1)" "unprognostic (3.31e-2)" "unprognostic (1.11e-1)" "unprognostic (5.26e-3)" "unprognostic (9.58e-2)" "unprognostic (5.58e-2)" "unprognostic (1.08e-1)" "unprognostic (2.93e-2)" 8.6 1.7 0.7 5.6 0.7 4.9 8.0 0.7 1.4 6.4 0.8 15.2 10.2 3.2 1.4 11.9 3.8 5.4 4.1 0.7 0.7 6.2 1.7 8.1 7.7 1.2 0.8 0.7 7.9 0.8 1.2 3.2 1.1 3.4 11.0 0.0 8.9 1.5 1.5 6.5 18.3 2.1 0.8 18.6 10.6 1.1 1.1 3.5 10.7 1.3 7.6 5.4 7.5 1.1 0.0 0.0 0.0 0.0 2.4 2.7 0.0 0.6 3.4 0.0 0.0 0.1 7.0 0.1 1.7 0.3 0.0 1.6 0.0 0.1 0.0 4.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 1.2 1.1 0.0 0.1 0.0 0.0 0.0 0.5 0.0 10.1 0.0 0.0 0.0 1.2 1.2 0.0 0.0 0.0 0.0 11.1 0.0 0.0 1.9 2.9 1.5 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 1.6 0.0 1.7 3.3 4.2 3.7 5.1 3.9 2.1 3.1 3.7 3.3 2.4 1.6 2.3 1.9 2.7 6.0 1.6 6.1 2.9 0.7 0.7 0.7 1.4 0.7 0.7 1.2 0.8 1.1 0.8 1.1 1.1 5.5 3.2 9.1 0.0 5.7 1.5 1.4 5.8 1.8 0.0 2.0 0.9 0.7 2.8 4.7 3.7 0.0 0.3 9.6 38.5 3.9 8.1 0.1 3.2 0.8 4.2 6.1 1.3 0.0 35.2 0.4 1.9 22.4 5.4 12.6 0.0 0.7 0.0 12.7 0.0 0.0 14.4 4.1 9.5 1.6 0.3 0.0 7.7 3.6 1.9 11.6 0.0 10.3 0.0 0.0 17.8 21.4 0.0 5.5 0.5 22.5 0.1 3.7 0.0 0.0 0.2 1.0 0.0 0.3 3.9 1.4 0.3 8.3 0.1 8.0 3.3 RIPK4 "ANKK2, ANKRD3, DIK, PKK, RIP4" ENSG00000183421 "Receptor interacting serine/threonine kinase 4" P57078 21 41739369-41767089 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Disease variant, Ectodermal dysplasia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 72.2" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 52.3;Endometrial ciliated cells: 76.5;Gastric mucus-secreting cells: 61.2;Glandular and luminal cells: 174.2;Squamous epithelial cells: 71.2" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "CAPAN-2: 32.2;GAMG: 41.2;HaCaT: 47.5;hTCEpi: 31.4;RPTEC TERT1: 28.3;RT4: 30.8" "Low region specificity" "Detected in single" "Low region specificity" "Detected in some" HPA030942 Enhanced NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 44: Endometrium - Transcription" "HPA030942: AB_2732462" "unprognostic (8.93e-2)" "unprognostic (2.67e-1)" "unprognostic (6.32e-3)" "unprognostic (7.87e-2)" "unprognostic (1.24e-1)" "unprognostic (5.61e-2)" "unprognostic (1.30e-1)" "unprognostic (2.88e-2)" "unprognostic (1.02e-1)" "prognostic unfavorable (6.22e-5)" "prognostic unfavorable (3.48e-4)" "unprognostic (9.98e-2)" "prognostic favorable (6.52e-4)" "unprognostic (2.69e-1)" "unprognostic (2.95e-3)" "unprognostic (2.28e-1)" "unprognostic (2.78e-2)" 1.6 0.0 0.1 0.4 0.0 0.6 4.3 0.0 0.1 11.8 3.7 3.1 9.7 1.1 2.4 72.2 5.8 5.2 1.5 0.1 0.1 11.5 19.1 4.2 0.1 0.3 0.6 0.1 14.3 7.4 10.8 2.3 0.1 10.7 2.0 0.6 14.8 9.8 0.0 21.5 13.6 0.1 0.1 0.0 15.5 2.0 0.1 7.8 7.9 0.0 5.2 6.3 22.3 0.1 14.3 9.0 0.0 0.0 0.0 0.0 13.7 0.1 0.1 0.2 0.2 23.5 32.2 0.0 13.3 2.9 41.2 47.5 0.7 19.2 0.0 0.0 9.4 0.0 6.9 8.8 0.0 0.0 0.0 0.0 31.4 0.2 4.2 0.0 0.0 14.3 0.0 0.0 0.0 10.3 2.0 0.0 0.8 9.3 26.1 0.0 0.0 2.3 28.3 30.8 4.5 0.3 15.5 15.7 15.1 1.3 9.6 0.0 0.0 0.2 0.1 0.0 0.2 0.0 0.0 0.0 4.2 0.0 11.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.1 0.3 0.6 0.1 0.1 0.1 0.1 0.1 28.9 9.1 0.0 0.1 15.8 27.4 24.0 52.3 0.0 13.0 12.4 1.1 17.2 28.0 3.7 0.0 8.3 0.3 22.8 9.8 12.4 1.5 76.5 16.9 0.9 22.7 0.0 0.0 10.4 5.1 0.6 61.2 174.2 2.5 0.0 0.0 17.0 1.0 0.0 0.0 14.2 16.2 0.6 1.4 1.6 0.0 0.9 7.2 0.0 0.0 0.4 0.0 0.0 0.0 19.0 11.8 0.0 0.0 24.0 26.5 13.5 22.2 0.9 0.0 0.0 1.3 1.4 2.5 71.2 15.2 2.5 1.5 0.0 11.2 24.1 RLIM "MGC15161, NY-REN-43, RNF12" ENSG00000131263 "Ring finger protein, LIM domain interacting" Q9NVW2 X 74582976-74614624 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" Transferase "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA018895 Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 38: Basophils - Unknown function" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 41: Macrophages - Immune response" Nucleoplasm Cytosol "HPA018895: AB_1856323" "unprognostic (1.17e-2)" "unprognostic (1.08e-1)" "unprognostic (1.72e-1)" "unprognostic (1.31e-3)" "unprognostic (1.25e-1)" "unprognostic (1.03e-1)" "unprognostic (8.98e-3)" "unprognostic (1.36e-1)" "unprognostic (1.03e-1)" "unprognostic (2.06e-1)" "unprognostic (1.12e-1)" "unprognostic (4.91e-2)" "unprognostic (2.25e-1)" "unprognostic (3.82e-2)" "unprognostic (1.24e-1)" "prognostic unfavorable (6.04e-4)" "unprognostic (1.20e-1)" 11.3 11.8 10.6 10.4 11.7 41.2 10.5 5.9 9.9 10.0 10.0 6.8 5.9 9.5 5.6 8.7 8.4 9.6 8.8 11.2 15.1 10.0 8.3 12.1 8.9 8.5 10.3 10.6 7.5 11.7 10.3 9.8 10.3 9.8 6.6 10.7 7.4 7.1 9.6 9.4 6.1 9.3 7.3 9.3 7.4 6.5 12.6 11.0 11.7 8.6 9.5 8.5 8.0 8.2 23.7 24.2 22.8 18.7 20.1 22.5 22.4 22.4 26.0 19.9 24.4 18.9 24.4 12.8 25.4 28.6 26.7 19.9 45.9 26.7 30.1 11.7 23.9 22.7 43.2 10.7 17.4 34.6 38.6 21.7 14.4 28.2 46.5 15.6 23.3 20.9 19.9 22.9 24.6 18.1 26.0 16.8 35.0 12.9 22.5 24.3 48.0 21.5 16.1 28.6 16.4 19.5 42.3 19.0 24.5 20.4 11.2 24.9 31.0 23.4 23.1 24.8 19.6 12.0 24.6 20.3 25.5 33.1 23.2 22.8 6.0 5.9 3.1 7.5 3.1 3.0 3.9 3.8 4.9 3.3 4.2 3.8 11.5 5.3 5.6 2.6 4.8 3.2 10.6 11.7 5.9 9.9 11.2 15.1 8.5 10.3 10.3 7.3 12.6 8.2 44.8 16.0 17.0 13.4 22.4 35.8 29.6 16.1 23.3 13.8 18.3 13.5 30.5 18.6 20.4 25.8 14.6 16.3 27.6 10.3 11.7 13.7 7.9 32.3 35.3 30.1 23.2 12.8 19.2 10.7 21.5 27.7 27.0 41.0 38.0 24.6 21.0 14.8 18.2 21.9 18.9 10.6 10.2 20.7 34.1 4.4 9.9 29.1 17.8 15.9 12.7 13.2 12.3 11.1 16.4 14.8 8.5 18.8 16.3 25.5 6.8 12.0 25.2 14.6 6.6 31.1 24.1 9.7 18.2 21.6 38.8 26.3 22.0 19.0 11.4 37.2 RMND5A "FLJ13910, GID2, GID2A, p44CTLH, RMD5" ENSG00000153561 "Required for meiotic nuclear division 5 homolog A" Q9H871 2 86720291-86778041 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA046795, HPA060843" Uncertain Supported Nucleoplasm NA NA "Cluster 38: Basophils - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 6: Erythroid cells - Oxygen transport" Nucleoplasm "HPA046795: AB_10963573, HPA060843: AB_2684378" "unprognostic (4.54e-2)" "unprognostic (9.23e-2)" "unprognostic (3.45e-2)" "prognostic unfavorable (3.03e-4)" "unprognostic (2.32e-2)" "unprognostic (4.40e-2)" "unprognostic (1.52e-1)" "unprognostic (1.37e-1)" "unprognostic (3.00e-2)" "unprognostic (1.49e-2)" "unprognostic (1.04e-2)" "unprognostic (2.36e-1)" "unprognostic (1.29e-2)" "unprognostic (8.34e-3)" "unprognostic (1.41e-1)" "unprognostic (1.47e-1)" "unprognostic (1.56e-1)" 17.8 11.2 19.4 9.3 24.3 31.2 16.2 54.5 25.2 13.4 20.0 19.7 16.4 13.0 13.3 31.3 12.9 6.8 38.2 21.6 17.5 18.2 42.9 10.5 11.6 18.4 20.6 11.1 11.6 20.8 7.9 11.6 18.3 12.4 21.2 18.9 11.4 11.1 63.6 22.4 15.5 13.7 20.4 14.3 12.1 7.8 18.7 31.4 13.0 37.0 14.0 10.0 17.0 28.8 19.4 10.2 17.6 10.5 22.9 10.1 36.3 7.5 6.1 9.7 11.0 37.6 20.3 66.7 22.4 6.9 11.3 22.6 45.1 15.8 15.0 19.4 34.4 58.7 21.8 34.2 23.1 43.2 18.6 15.4 30.5 10.2 35.2 11.0 17.0 48.7 37.7 37.3 7.9 12.6 40.1 36.9 29.8 23.1 13.0 47.3 54.2 42.3 20.1 22.8 32.6 25.1 16.9 33.5 27.9 24.8 16.8 36.8 16.3 6.7 12.9 12.2 11.7 16.7 18.8 45.0 5.6 51.3 7.8 37.5 11.9 8.1 8.1 10.1 9.7 4.7 6.2 9.1 9.4 6.4 8.4 11.6 27.5 8.8 12.5 7.4 4.7 8.6 19.4 24.3 54.5 25.2 21.6 17.5 18.4 20.6 18.3 20.4 18.7 28.8 32.8 12.8 15.9 15.3 27.0 41.9 23.4 10.4 46.7 26.3 25.5 15.6 93.2 24.3 10.5 11.0 6.2 21.0 36.2 73.3 23.5 13.1 13.7 33.8 28.7 26.0 39.5 105.2 27.3 14.1 18.6 20.1 24.5 35.3 8.2 16.3 25.0 76.7 15.1 23.5 27.2 57.4 14.2 34.4 42.7 5.6 19.3 26.3 32.0 14.0 23.7 15.3 30.9 10.6 42.3 21.9 30.9 17.3 30.1 34.8 38.1 34.4 26.6 16.3 6.6 22.7 20.1 17.9 27.8 50.0 54.8 24.6 31.4 24.6 28.7 34.0 RMND5B "FLJ22318, GID2, GID2B" ENSG00000145916 "Required for meiotic nuclear division 5 homolog B" Q96G75 5 178130996-178150568 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 186.6;Late spermatids: 415.4;Spermatocytes: 133.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HDLM-2: 130.3;MCF7: 185.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA047778 Uncertain NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 23: Testis - Cell cycle regulation" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 25: Spermatids - Spermatogenesis" "HPA047778: AB_2680153" "unprognostic (2.08e-1)" "unprognostic (6.83e-2)" "unprognostic (2.58e-1)" "unprognostic (1.35e-2)" "unprognostic (4.38e-2)" "unprognostic (9.81e-3)" "unprognostic (2.64e-3)" "unprognostic (1.18e-1)" "unprognostic (1.32e-1)" "unprognostic (2.48e-1)" "prognostic favorable (7.66e-4)" "unprognostic (1.60e-1)" "prognostic favorable (7.22e-8)" "unprognostic (1.77e-2)" "unprognostic (1.41e-1)" "unprognostic (6.43e-2)" "unprognostic (5.78e-2)" 18.9 23.4 19.8 11.2 19.7 13.2 18.8 19.2 20.3 24.0 19.4 24.5 13.2 22.7 12.2 69.8 19.2 9.6 28.1 19.7 18.7 22.4 27.2 17.4 18.0 22.3 19.4 17.1 25.4 23.5 20.7 16.4 19.1 19.0 11.4 10.5 24.2 15.9 45.6 29.6 17.3 15.9 19.6 19.2 23.2 81.6 21.2 23.7 20.5 32.4 23.0 22.1 28.2 20.9 21.3 37.5 21.4 53.5 27.4 2.8 71.3 16.9 18.2 25.1 29.2 42.1 30.2 44.6 32.9 11.9 27.6 27.6 21.5 36.7 8.8 130.3 28.7 46.8 39.1 22.8 29.0 21.9 16.3 5.9 27.1 17.3 27.3 14.0 25.5 14.7 40.1 28.8 8.1 185.2 15.5 12.5 29.5 25.9 20.4 19.7 15.8 31.6 21.1 32.4 22.5 32.2 22.8 73.0 40.3 17.3 56.9 29.5 17.7 13.9 21.9 12.8 21.3 42.4 43.4 37.0 18.2 21.2 19.6 21.8 16.5 42.5 6.5 20.1 2.8 18.3 13.0 7.3 8.8 24.9 20.4 11.3 11.4 4.2 27.2 13.7 22.4 12.4 19.8 19.7 19.2 20.3 19.7 18.7 22.3 19.4 19.1 19.6 21.2 20.9 13.5 12.8 6.9 7.8 20.5 9.6 20.6 15.3 14.2 48.6 19.3 16.1 22.2 27.1 12.2 31.3 52.1 31.7 8.0 17.6 23.5 21.0 186.6 7.8 10.2 13.3 9.0 28.0 15.4 19.1 29.8 16.7 23.0 10.5 5.1 16.4 15.0 14.0 21.7 48.8 16.6 15.0 28.5 15.0 9.6 415.4 28.9 10.5 7.2 10.3 22.7 30.9 14.4 8.5 14.1 19.1 13.3 25.2 14.8 20.6 26.1 21.6 7.3 61.4 13.1 17.5 16.3 133.0 35.7 28.9 13.4 44.5 10.9 18.5 17.9 20.0 RNF103 "hkf-1, KF1, ZFP103" ENSG00000239305 "Ring finger protein 103" O00237 2 86603398-86623866 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "eosinophil: 7.2" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA057922 Approved NA NA "Cluster 46: Basophils - DNA binding" "Cluster 15: Liver - Metabolism" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 35: Glandular cells - Unknown function" "HPA057922: AB_2683555" "unprognostic (4.41e-1)" "unprognostic (1.56e-1)" "unprognostic (6.04e-2)" "unprognostic (3.26e-1)" "unprognostic (3.20e-2)" "unprognostic (1.79e-1)" "unprognostic (7.42e-2)" "unprognostic (8.37e-2)" "unprognostic (4.06e-1)" "unprognostic (1.13e-2)" "unprognostic (6.21e-2)" "unprognostic (1.44e-1)" "unprognostic (3.54e-3)" "unprognostic (1.50e-1)" "unprognostic (1.77e-1)" "unprognostic (3.67e-2)" "prognostic favorable (6.77e-5)" 14.6 15.3 25.7 9.0 28.8 13.6 20.9 35.8 31.6 15.9 22.6 21.9 18.7 23.7 45.4 14.0 16.9 19.4 37.7 24.8 25.1 15.3 54.5 11.3 8.1 26.8 27.2 16.0 24.7 25.2 15.6 15.6 25.7 23.3 16.5 10.3 18.7 17.7 21.4 14.3 23.0 21.0 27.2 10.5 22.6 15.4 26.7 8.1 10.2 19.1 10.0 14.4 13.9 30.6 9.6 12.9 6.4 9.9 28.6 18.3 10.3 13.6 20.6 6.8 9.2 7.5 16.1 15.9 15.9 20.4 24.8 11.5 8.7 10.7 10.2 13.4 11.7 9.1 5.4 16.7 27.1 3.0 13.0 26.9 21.8 10.1 12.6 24.3 20.7 7.4 3.3 9.3 19.0 11.9 7.0 8.0 2.9 19.0 9.0 4.3 27.5 9.4 25.1 14.9 10.2 10.4 16.0 35.2 14.0 8.0 13.5 7.4 23.6 13.2 6.3 13.4 8.2 32.3 11.5 10.7 10.5 5.1 6.5 4.5 0.5 7.2 0.7 0.7 1.0 0.9 1.1 1.6 1.1 1.0 1.2 0.9 1.0 2.3 0.4 0.8 2.5 0.6 25.7 28.8 35.8 31.6 24.8 25.1 26.8 27.2 25.7 27.2 26.7 30.6 22.6 9.6 14.5 0.0 16.6 48.3 35.5 13.9 33.6 15.8 45.9 31.1 40.0 31.5 22.1 20.2 4.2 13.6 15.7 72.4 1.9 17.6 16.8 20.4 17.9 22.4 31.8 16.4 0.0 28.4 7.8 27.6 44.4 30.0 18.4 19.9 22.9 68.9 9.6 18.5 0.0 45.9 12.2 14.1 29.5 9.3 25.4 19.8 10.6 0.0 8.0 17.2 2.1 0.0 0.0 33.9 41.5 23.0 41.1 45.0 56.1 12.9 33.6 9.5 6.6 40.3 25.7 27.5 12.6 32.6 44.2 40.9 19.5 9.0 24.3 48.6 RNF111 "ARK, Arkadia, DKFZP761D081, FLJ38008" ENSG00000157450 "Ring finger protein 111" Q6ZNA4 15 58865175-59097419 "Enzymes, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Developmental protein, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 81.6;Inhibitory neurons: 80.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038576, HPA038577" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 34: Non-specific - Transcription" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 59: Non-specific - Transcription" Nucleoplasm Cytosol "HPA038576: AB_10964492, HPA038577: AB_10960052" "unprognostic (7.30e-2)" "unprognostic (2.60e-2)" "unprognostic (2.39e-1)" "unprognostic (3.37e-1)" "unprognostic (7.94e-2)" "unprognostic (2.09e-1)" "unprognostic (2.19e-1)" "unprognostic (3.21e-1)" "unprognostic (5.10e-2)" "unprognostic (6.12e-3)" "unprognostic (3.10e-2)" "unprognostic (1.42e-1)" "unprognostic (2.05e-3)" "unprognostic (2.05e-1)" "unprognostic (6.61e-2)" "unprognostic (1.20e-1)" "unprognostic (9.74e-2)" 8.2 7.5 2.0 11.8 3.1 17.3 7.8 8.7 5.3 8.6 1.4 7.2 8.4 9.0 6.7 11.4 8.7 9.3 7.3 3.5 4.7 8.8 10.5 8.4 10.8 1.4 1.7 11.4 9.2 11.9 4.3 11.4 2.1 8.7 7.2 12.5 8.1 8.3 9.5 8.2 8.0 8.3 1.2 11.0 9.0 9.4 3.2 11.5 11.6 11.8 13.3 10.3 7.2 4.3 13.8 31.3 19.6 16.8 16.6 18.5 16.7 17.6 20.6 17.2 22.0 13.9 8.9 16.8 19.4 24.8 14.7 26.3 5.3 13.1 21.3 17.6 11.1 20.9 12.6 10.7 18.0 12.3 22.6 14.7 14.0 18.6 20.4 15.6 19.5 15.4 19.7 16.4 21.5 6.7 16.3 7.9 16.1 4.3 12.0 16.2 27.9 13.8 13.1 24.2 16.0 23.3 15.8 15.5 14.7 22.7 12.2 14.9 22.6 27.4 22.8 14.5 17.1 11.8 17.3 19.9 16.7 19.5 21.1 11.4 15.0 15.7 7.0 11.0 7.1 11.8 7.2 6.5 8.3 10.9 7.9 6.3 41.0 5.6 13.0 7.9 10.0 3.4 2.0 3.1 8.7 5.3 3.5 4.7 1.4 1.7 2.1 1.2 3.2 4.3 11.7 3.2 14.4 34.6 31.9 20.1 12.3 7.3 26.7 12.2 13.0 10.2 19.7 7.2 10.6 12.9 8.4 9.0 12.8 10.0 3.9 12.6 27.6 14.4 15.1 15.3 16.2 11.6 81.6 6.9 10.5 15.0 17.3 15.8 15.8 12.3 17.9 11.2 13.4 10.1 80.4 10.0 12.2 19.8 15.7 7.5 7.8 21.2 12.4 56.2 22.7 8.4 16.5 65.4 66.2 12.9 11.4 14.7 19.5 14.5 11.6 9.9 14.9 13.6 26.3 15.1 13.6 13.8 8.9 27.3 19.9 32.0 21.4 11.8 9.2 21.2 RNF112 "BFP, ZNF179" ENSG00000128482 "Ring finger protein 112" Q9ULX5 17 19411125-19417276 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Neurogenesis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 33.8" "Cell type enhanced" "Detected in some" "Astrocytes: 8.1;Bipolar cells: 6.6;Excitatory neurons: 19.6;Inhibitory neurons: 11.6;Muller glia cells: 7.6;Oligodendrocyte precursor cells: 13.6;Sertoli cells: 6.6" "Cancer enriched" "Detected in some" 8 "glioma: 6.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "ASC TERT1: 5.2;fHDF/TERT166: 6.2;SCLC-21H: 6.0;SH-SY5Y: 10.6;U-87 MG: 34.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA015970 Enhanced Approved "Nuclear speckles" NA NA "Cluster 65: Brain - Ion transport" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nuclear speckles" "HPA015970: AB_1859103" "unprognostic (1.16e-1)" "unprognostic (3.74e-1)" "unprognostic (8.43e-5)" "unprognostic (3.65e-2)" "unprognostic (2.96e-2)" "unprognostic (6.02e-2)" "unprognostic (1.27e-1)" "unprognostic (2.88e-1)" "unprognostic (4.26e-1)" "unprognostic (5.02e-2)" "unprognostic (3.17e-1)" "unprognostic (2.96e-1)" "unprognostic (1.31e-9)" "unprognostic (1.32e-1)" "unprognostic (1.07e-1)" "unprognostic (1.59e-1)" "unprognostic (4.24e-1)" 2.2 5.4 20.2 1.5 21.9 0.1 1.9 33.8 25.0 3.2 7.2 9.4 1.8 3.0 4.5 1.7 3.2 2.8 3.6 24.7 16.8 3.9 1.0 2.8 0.7 12.7 14.2 2.4 1.3 0.0 5.5 0.5 14.0 12.3 2.8 1.5 1.2 2.0 1.3 1.9 6.9 2.2 12.9 3.0 2.5 2.3 16.6 0.2 2.2 1.3 0.2 8.4 3.2 23.2 0.0 0.0 0.1 0.4 1.4 5.2 0.2 0.3 1.2 0.1 0.0 0.2 0.0 0.0 0.1 6.2 0.0 0.2 0.0 0.0 0.0 0.3 0.2 0.0 0.0 0.0 4.2 0.0 0.1 2.1 0.2 0.2 0.3 0.9 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.5 0.0 0.4 0.1 0.2 0.2 0.0 0.0 6.0 10.6 0.1 0.0 0.0 1.4 0.1 0.1 0.1 0.0 0.3 0.6 0.0 0.1 0.0 0.0 34.6 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 20.2 21.9 33.8 25.0 24.7 16.8 12.7 14.2 14.0 12.9 16.6 23.2 1.1 0.0 0.0 8.1 0.0 1.0 0.0 0.2 0.0 6.6 0.1 0.4 0.8 0.0 0.0 0.0 0.0 0.0 0.3 0.8 0.0 0.0 0.1 0.2 0.3 0.5 0.0 0.0 19.6 0.0 0.0 3.3 0.0 0.2 0.0 0.8 0.0 0.0 0.0 0.0 11.6 0.2 0.0 0.6 0.4 0.2 0.0 0.3 0.0 4.7 0.1 7.6 1.0 13.6 3.3 0.0 1.4 3.8 0.0 0.2 0.5 0.0 0.1 0.7 6.6 1.4 1.5 1.7 0.7 0.3 1.0 0.3 0.2 0.0 0.1 0.1 RNF113A "Cwc24, RNF113, ZNF183" ENSG00000125352 "Ring finger protein 113A" O15541 X 119870475-119871733 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, mRNA processing, mRNA splicing, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000160, HPA076658" Approved Supported Nucleoplasm NA NA "Cluster 44: Non-specific - Transcription" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 63: NK-cells & T-cells - Immune response" Nucleoplasm "HPA000160: AB_1079821, HPA076658: AB_2732319" "unprognostic (2.85e-1)" "unprognostic (4.38e-3)" "unprognostic (5.55e-3)" "unprognostic (2.38e-2)" "unprognostic (1.02e-1)" "unprognostic (1.28e-2)" "unprognostic (3.65e-3)" "unprognostic (2.02e-3)" "unprognostic (6.29e-2)" "unprognostic (2.57e-1)" "unprognostic (6.49e-3)" "unprognostic (1.83e-1)" "prognostic unfavorable (7.93e-4)" "unprognostic (7.99e-2)" "unprognostic (3.19e-1)" "unprognostic (3.91e-2)" "prognostic favorable (6.23e-4)" 11.0 9.6 11.5 13.0 12.1 35.3 10.2 13.0 14.4 10.5 11.3 11.4 13.2 9.8 9.6 11.3 10.2 8.2 12.7 11.7 13.9 9.2 17.7 11.0 24.7 12.7 13.0 13.4 19.1 9.2 10.0 9.0 13.1 8.9 9.5 15.6 14.4 8.8 12.3 17.1 17.5 7.5 11.9 24.3 12.1 3.4 13.1 24.7 9.9 10.6 19.0 10.8 10.3 12.6 16.9 22.9 11.0 17.7 20.7 14.9 22.3 14.8 25.0 17.6 21.0 19.7 14.1 28.0 28.1 13.8 25.1 20.4 24.4 19.1 13.1 21.9 18.0 17.0 25.8 23.5 28.3 33.7 28.3 18.4 20.6 17.7 26.0 20.7 17.1 19.4 12.2 38.4 17.3 47.5 23.5 39.9 16.1 29.5 32.8 21.7 23.2 45.3 18.5 20.6 14.7 12.9 23.1 35.5 33.1 12.9 8.7 32.9 13.1 18.6 6.6 26.7 29.7 43.2 36.0 27.9 16.8 44.1 12.3 96.4 59.5 109.5 73.9 60.3 74.4 83.6 78.3 79.0 63.4 88.6 81.3 73.1 27.5 65.9 72.6 53.3 96.6 73.6 11.5 12.1 13.0 14.4 11.7 13.9 12.7 13.0 13.1 11.9 13.1 12.6 14.8 9.6 14.8 2.6 42.8 24.3 17.2 26.6 30.7 11.5 13.6 21.1 8.9 18.6 21.4 14.7 14.6 18.5 51.6 10.8 9.8 18.3 0.5 13.1 18.8 17.4 4.2 10.3 3.0 16.8 37.6 15.2 16.3 16.5 26.5 14.4 18.2 13.1 24.4 13.5 4.1 16.8 14.2 17.6 23.1 1.4 12.2 17.0 26.6 5.6 17.2 16.5 39.1 2.0 6.2 15.5 17.8 9.8 59.6 12.3 34.9 25.1 19.6 17.7 6.6 8.3 19.3 2.9 5.8 20.9 24.4 26.4 50.2 15.9 15.5 14.3 RNF114 "PSORS12, ZNF313" ENSG00000124226 "Ring finger protein 114" Q9Y508 20 49936336-49953885 "Enzymes, Predicted intracellular proteins" "Differentiation, Spermatogenesis, Ubl conjugation pathway" "Developmental protein, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 6 "Early spermatids: 1500.7;Late spermatids: 923.4;Spermatocytes: 558.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "SK-BR-3: 561.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA021184 Enhanced Supported "Plasma membrane,Cytosol" NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 78: Testis - Spermatogenesis" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 66: Spermatocytes - Spermatogenesis" "Plasma membrane, Cytosol" "HPA021184: AB_1859185" "unprognostic (8.38e-2)" "unprognostic (3.56e-2)" "unprognostic (5.62e-2)" "prognostic unfavorable (8.10e-6)" "unprognostic (1.56e-1)" "unprognostic (2.96e-1)" "prognostic unfavorable (3.11e-4)" "unprognostic (2.50e-2)" "unprognostic (1.03e-2)" "unprognostic (2.12e-1)" "unprognostic (3.99e-1)" "unprognostic (2.70e-2)" "unprognostic (2.54e-3)" "unprognostic (1.33e-1)" "unprognostic (1.76e-1)" "prognostic favorable (3.01e-4)" "unprognostic (1.36e-2)" 32.8 32.0 43.3 29.7 48.2 51.6 31.2 46.6 45.1 37.2 41.0 45.0 42.8 28.7 32.8 30.8 34.7 28.8 37.6 40.4 44.9 48.6 49.0 37.9 39.3 47.3 46.5 39.0 52.2 30.2 28.1 35.1 46.6 33.9 40.0 16.7 41.0 34.1 83.3 24.2 40.8 25.4 47.1 52.4 35.9 166.1 47.2 39.1 37.9 52.8 37.3 28.9 28.7 49.9 83.9 80.5 42.9 43.7 84.3 57.8 118.0 73.0 86.2 153.2 64.4 241.7 67.6 39.9 142.9 40.1 91.6 66.3 62.5 74.7 90.6 73.5 44.3 51.5 50.1 173.2 73.3 95.3 59.5 51.5 68.8 58.4 39.9 52.6 36.8 69.7 98.0 46.7 45.5 281.0 82.6 98.0 42.3 67.4 114.3 85.7 45.5 73.6 83.4 67.9 63.2 45.4 88.8 561.6 118.5 45.4 149.7 86.6 47.8 134.6 62.3 71.6 87.0 93.6 107.1 79.2 76.4 63.2 76.1 112.2 97.8 86.1 48.1 92.5 53.1 63.9 52.6 48.6 75.3 71.2 61.6 50.2 100.5 57.8 112.5 61.9 68.9 92.7 43.3 48.2 46.6 45.1 40.4 44.9 47.3 46.5 46.6 47.1 47.2 49.9 47.1 48.1 53.7 13.4 69.9 107.2 127.8 103.4 63.2 24.4 50.7 55.8 46.1 41.5 101.4 69.9 12.5 91.3 61.0 61.7 72.4 107.5 1500.7 72.2 36.3 55.3 60.4 45.4 22.8 101.1 77.4 61.9 41.3 71.4 45.0 31.9 46.1 63.7 110.6 40.4 24.4 79.5 42.7 76.6 146.5 923.4 70.5 66.0 71.2 27.2 96.3 38.0 56.7 10.6 26.2 92.1 77.9 59.8 81.9 122.5 96.4 120.9 75.8 22.6 39.5 45.5 59.2 558.0 138.4 45.8 87.1 124.8 69.2 46.5 80.4 113.3 RNF115 "CL469780, ZNF364" ENSG00000265491 "Ring finger protein 115" Q9Y4L5 1 145738868-145824095 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 6.4" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019130 Approved Approved Nucleoli,Mitochondria NA NA "Cluster 34: Basophils - Unknown function" "Cluster 38: Heart - Muscle contraction" "Cluster 3: HMC-1 - Innate immune response" "Cluster 24: Non-specific - Transcription regulation" "Nucleoli, Mitochondria" "HPA019130: AB_1859220" "unprognostic (3.44e-2)" "unprognostic (2.47e-3)" "unprognostic (2.24e-1)" "unprognostic (1.09e-1)" "unprognostic (5.48e-2)" "unprognostic (1.90e-1)" "prognostic unfavorable (2.95e-4)" "unprognostic (2.29e-2)" "unprognostic (1.46e-2)" "unprognostic (1.35e-1)" "unprognostic (2.64e-2)" "unprognostic (7.29e-2)" "unprognostic (1.44e-2)" "unprognostic (3.23e-1)" "unprognostic (4.77e-2)" "unprognostic (2.46e-2)" "unprognostic (1.08e-1)" 8.9 5.0 7.7 4.6 7.3 7.5 7.5 16.1 9.0 7.1 6.1 9.0 3.4 12.2 4.1 5.7 7.9 4.7 24.9 7.7 6.8 5.6 5.1 5.9 5.0 6.3 6.8 5.5 5.3 6.8 5.3 3.5 6.6 7.3 3.7 13.9 5.9 5.2 32.1 6.1 5.5 11.1 5.7 5.0 5.8 3.9 7.5 5.0 6.1 25.3 4.7 7.9 5.6 7.1 11.0 4.5 5.4 3.9 9.6 12.5 4.2 8.1 15.1 5.9 7.1 4.9 3.8 7.7 9.0 11.7 5.7 7.5 6.0 5.5 6.3 7.7 3.9 6.1 5.9 4.6 6.1 9.7 13.7 7.3 4.8 6.0 7.1 6.7 7.7 5.9 6.1 12.2 10.8 8.3 7.1 6.0 6.8 7.0 9.4 6.7 5.4 6.4 11.6 3.6 5.3 7.4 6.6 8.0 6.3 6.6 8.9 9.1 9.4 8.4 6.6 5.1 8.7 10.2 10.3 8.0 4.2 6.4 5.4 6.4 1.0 1.6 1.4 0.8 1.2 1.5 1.0 1.4 0.8 1.2 1.0 1.4 0.7 1.6 0.8 1.1 1.0 0.7 7.7 7.3 16.1 9.0 7.7 6.8 6.3 6.8 6.6 5.7 7.5 7.1 168.4 16.0 29.2 61.7 43.5 20.6 32.6 24.4 23.9 101.3 35.9 29.1 152.5 38.6 27.0 18.4 114.7 26.8 155.6 13.2 33.2 44.8 68.5 52.9 45.4 72.3 27.1 60.6 91.2 80.3 28.7 60.8 28.1 55.8 31.7 39.1 71.7 33.1 37.2 82.4 77.6 23.5 28.5 41.5 36.2 25.3 39.4 38.9 39.2 84.3 71.0 64.4 90.6 81.4 83.9 52.4 18.8 80.9 90.5 76.0 22.5 46.6 29.6 111.1 59.2 60.2 53.5 76.5 63.7 23.7 18.0 19.8 75.7 65.2 23.6 40.2 RNF123 "FLJ12565, KPC1" ENSG00000164068 "Ring finger protein 123" Q5XPI4 3 49689538-49721529 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 156.1;tongue: 112.0" "Cell type enhanced" "Detected in many" "Erythroid cells: 52.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA065983, HPA071879" Supported Approved Cytosol NA NA 140000 "Cluster 37: B-cells - Transcription" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 6: Erythroid cells - Oxygen transport" Cytosol "HPA065983: AB_2685592, HPA071879: AB_2686468" "unprognostic (2.68e-1)" "unprognostic (3.34e-1)" "unprognostic (2.67e-1)" "unprognostic (1.04e-1)" "unprognostic (2.21e-1)" "unprognostic (9.51e-2)" "unprognostic (2.04e-1)" "unprognostic (3.75e-1)" "unprognostic (4.08e-1)" "unprognostic (1.07e-1)" "unprognostic (7.51e-2)" "unprognostic (5.03e-3)" "prognostic favorable (1.33e-8)" "unprognostic (5.69e-2)" "unprognostic (1.74e-1)" "unprognostic (7.22e-2)" "unprognostic (3.83e-1)" 13.0 19.0 18.9 9.0 19.2 34.6 12.5 18.5 23.9 13.1 21.0 17.8 19.5 14.7 10.5 13.4 12.5 9.7 27.8 19.6 16.5 22.0 57.7 12.3 10.4 17.5 16.9 11.6 13.5 16.3 17.4 9.4 17.2 14.6 6.8 6.0 14.4 9.2 156.1 14.5 18.2 9.3 14.7 17.9 17.9 23.7 18.0 13.7 14.6 112.0 7.3 14.2 12.0 17.9 9.7 12.6 15.5 16.2 23.2 13.9 17.1 12.1 15.9 15.0 16.0 14.1 16.1 23.2 10.9 17.6 13.3 11.8 11.6 18.1 10.0 15.8 15.0 19.7 27.8 31.6 23.1 19.3 19.8 17.6 17.9 14.4 16.5 14.8 16.2 23.0 20.0 20.0 13.2 14.1 19.8 30.7 8.2 11.5 21.0 9.3 9.7 24.4 21.5 16.4 10.6 20.8 16.4 14.4 18.7 8.7 15.4 33.0 16.2 13.4 16.3 11.9 14.9 26.4 28.4 9.5 19.2 23.6 20.5 8.9 6.9 5.6 6.7 6.2 4.0 7.1 4.5 4.1 5.5 7.0 5.3 5.0 4.0 5.5 6.8 7.9 3.6 3.8 18.9 19.2 18.5 23.9 19.6 16.5 17.5 16.9 17.2 14.7 18.0 17.9 7.1 9.6 5.3 16.3 6.5 2.3 3.1 4.7 1.8 8.6 7.1 6.1 1.1 11.5 5.8 3.7 4.2 6.8 9.3 10.4 5.9 5.3 13.3 8.1 5.8 5.9 6.7 52.4 18.0 5.5 4.6 5.9 11.2 7.5 7.0 9.5 10.0 29.8 5.6 6.7 14.6 6.1 10.2 9.6 1.4 16.5 7.5 6.0 3.6 5.6 6.3 5.4 7.2 7.5 7.2 7.2 6.3 5.7 7.0 5.0 19.2 10.2 5.4 8.9 0.0 7.6 5.6 10.7 8.9 4.6 3.0 8.5 6.0 7.5 6.9 4.1 RNF125 FLJ20456 ENSG00000101695 "Ring finger protein 125" Q96EQ8 18 32018825-32073219 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Adaptive immunity, Immunity, Ubl conjugation pathway" Transferase "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 18.4" "Cell type enhanced" "Detected in many" "dendritic cells: 169.6;Early spermatids: 90.7;NK-cells: 160.6;Oligodendrocytes: 64.3;T-cells: 114.8" "Cancer enhanced" "Detected in all" "testis cancer: 8.6" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HMC-1: 51.5;SK-MEL-30: 13.2;U-937: 11.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041514 Uncertain Supported "Nucleoli,Golgi apparatus" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 3: HMC-1 - Innate immune response" "Cluster 24: Non-specific - Transcription regulation" "Golgi apparatus" Nucleoli "HPA041514: AB_10795596" "unprognostic (2.13e-2)" "unprognostic (2.05e-2)" "unprognostic (2.88e-1)" "unprognostic (3.93e-1)" "unprognostic (5.03e-1)" "unprognostic (4.50e-2)" "unprognostic (2.30e-3)" "unprognostic (6.15e-2)" "unprognostic (4.21e-2)" "unprognostic (3.24e-1)" "unprognostic (1.68e-1)" "unprognostic (4.35e-2)" "prognostic unfavorable (4.06e-4)" "unprognostic (2.99e-1)" "unprognostic (4.12e-1)" "unprognostic (1.82e-1)" "unprognostic (7.07e-3)" 10.2 1.3 2.0 5.2 3.7 18.4 6.3 2.7 2.7 3.9 1.6 5.0 10.5 2.9 0.5 2.5 3.4 3.3 2.6 1.9 2.3 1.0 12.5 4.7 7.0 3.6 3.2 1.4 3.1 1.7 0.3 3.7 3.4 1.8 6.4 0.3 2.2 1.4 2.3 4.9 11.3 3.3 2.6 5.9 3.4 1.0 3.8 5.3 1.4 2.9 4.0 3.0 1.7 6.2 1.2 0.1 0.2 0.4 0.5 0.8 1.0 0.1 0.0 0.0 0.0 0.1 2.5 0.1 1.2 0.1 0.4 0.9 1.6 1.2 0.2 6.6 2.6 0.3 0.4 0.3 0.1 8.9 51.5 1.6 2.4 0.0 2.8 0.3 0.4 2.7 0.1 1.9 0.1 2.0 2.3 8.2 4.2 8.9 1.5 9.2 0.6 0.2 0.5 0.5 0.9 0.3 0.2 0.1 13.2 1.6 1.3 4.2 0.2 0.1 0.7 0.1 0.1 5.9 0.2 0.1 0.6 11.5 6.9 13.3 4.5 4.5 15.0 2.5 9.9 2.5 12.0 12.8 4.2 2.3 9.5 12.3 1.9 15.5 2.8 4.3 13.7 6.9 2.0 3.7 2.7 2.7 1.9 2.3 3.6 3.2 3.4 2.6 3.8 6.2 62.2 3.2 5.8 3.3 16.3 9.8 3.1 1.0 14.2 0.8 5.3 3.7 2.1 4.3 3.8 12.9 0.0 0.4 169.6 24.6 1.9 1.0 90.7 4.9 2.1 28.4 1.2 15.8 2.7 1.8 0.1 5.3 8.6 13.4 18.9 0.2 12.5 25.1 10.5 0.0 3.0 8.3 0.0 19.2 12.6 17.4 2.8 18.4 1.8 30.9 23.8 0.7 160.6 3.5 64.3 1.1 4.5 0.0 49.9 2.7 41.4 4.5 1.7 0.9 0.0 3.2 3.2 0.5 1.8 5.8 6.8 0.8 114.8 0.2 14.7 2.4 RNF126 FLJ20552 ENSG00000070423 "Ring finger protein 126" Q9BV68 19 647526-663233 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA043050 Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm Cytosol "HPA043050: AB_10794768" "unprognostic (2.24e-1)" "unprognostic (1.64e-1)" "unprognostic (1.97e-1)" "unprognostic (2.48e-3)" "unprognostic (1.90e-1)" "unprognostic (2.32e-1)" "unprognostic (1.09e-3)" "unprognostic (3.57e-2)" "unprognostic (1.28e-1)" "unprognostic (1.70e-1)" "unprognostic (1.88e-2)" "unprognostic (2.68e-2)" "unprognostic (9.96e-3)" "unprognostic (7.04e-3)" "unprognostic (3.39e-2)" "unprognostic (2.05e-1)" "unprognostic (4.67e-2)" 21.2 23.4 11.8 16.0 13.0 21.8 21.7 10.8 19.4 19.1 3.8 26.6 21.6 20.8 2.7 42.3 19.1 4.6 25.9 13.4 9.7 20.7 40.2 19.3 14.1 13.2 10.3 16.8 23.0 6.8 20.2 8.8 13.1 20.2 4.9 4.3 21.0 7.0 61.6 45.3 27.2 4.9 10.2 30.6 24.3 49.4 11.9 10.1 14.7 12.8 5.8 21.6 24.0 16.6 79.7 26.5 21.0 30.6 4.8 6.7 38.5 40.6 15.0 22.5 21.2 52.1 26.9 64.2 25.9 16.5 8.9 51.7 12.6 30.0 6.2 43.8 98.8 32.7 24.5 47.0 18.2 64.9 46.0 11.3 22.9 18.5 14.3 9.0 20.6 51.8 68.5 63.4 12.0 62.9 67.7 35.0 62.4 22.5 50.6 48.9 18.1 102.0 17.0 43.6 52.0 42.1 30.1 39.8 42.4 7.2 25.3 51.5 28.6 40.6 30.6 62.1 71.1 112.3 59.5 77.6 52.1 39.2 43.0 3.7 14.7 12.3 25.1 18.4 21.1 23.9 23.1 24.7 19.0 25.5 17.7 16.6 3.7 27.7 22.6 21.5 28.3 14.8 11.8 13.0 10.8 19.4 13.4 9.7 13.2 10.3 13.1 10.2 11.9 16.6 34.2 12.8 7.4 9.1 66.9 137.9 61.2 44.3 45.5 31.4 35.7 39.6 27.6 27.1 23.2 9.2 16.7 72.8 74.8 60.9 54.8 60.6 146.4 20.2 17.8 31.0 21.7 37.8 11.9 75.6 139.2 29.3 40.2 22.7 14.7 23.1 22.9 22.9 43.2 32.0 9.9 39.3 26.4 26.7 58.9 36.8 21.5 32.9 42.7 3.7 47.5 32.7 112.3 7.1 15.7 136.2 70.0 19.5 76.5 98.2 68.1 40.8 14.8 24.6 59.2 22.0 40.5 153.6 65.3 74.4 144.8 88.1 60.7 43.2 58.1 87.0 RNF128 "FLJ23516, GRAIL" ENSG00000133135 "Ring finger protein 128" Q8TEB7 X 106693794-106797016 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 62.1;liver: 124.6" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 67.3;Cholangiocytes: 50.1;Distal enterocytes: 49.3;Gastric mucus-secreting cells: 54.6;Hepatocytes: 76.9;Proximal enterocytes: 85.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 41.9;CAPAN-2: 35.0;Hep G2: 30.6;OE19: 96.2;RPTEC TERT1: 30.5;RT4: 88.8;WM-115: 53.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019675 Uncertain NA NA "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 21: OE19 - Mitochondria" "Cluster 45: Enterocytes - Digestion" "HPA019675: AB_2670225" "unprognostic (1.78e-1)" "unprognostic (1.44e-2)" "unprognostic (1.23e-1)" "unprognostic (1.88e-3)" "unprognostic (1.92e-4)" "unprognostic (2.14e-3)" "unprognostic (2.37e-2)" "unprognostic (1.02e-1)" "unprognostic (2.06e-1)" "unprognostic (2.43e-2)" "unprognostic (1.55e-2)" "unprognostic (1.75e-2)" "prognostic unfavorable (1.07e-7)" "unprognostic (1.11e-2)" "unprognostic (7.61e-2)" "unprognostic (6.30e-2)" "unprognostic (5.30e-3)" 0.7 35.0 2.6 1.8 2.4 0.0 7.9 1.9 2.4 0.6 0.8 21.8 62.1 0.1 0.5 4.6 1.0 33.1 0.5 2.5 4.2 31.5 124.6 14.7 0.2 2.7 2.2 2.0 16.4 0.7 6.6 11.1 3.3 2.8 19.6 0.1 28.6 2.1 8.9 6.9 60.8 0.6 1.6 0.1 46.9 0.6 4.3 2.8 29.4 4.1 0.2 20.0 2.0 1.6 11.1 0.0 0.0 0.0 3.4 1.8 41.9 0.1 0.3 0.0 0.0 18.8 35.0 0.0 0.0 0.6 0.4 13.3 0.1 0.0 0.0 0.0 20.6 0.0 0.3 30.6 0.0 0.0 0.0 0.1 14.4 0.0 0.1 2.2 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 2.4 96.2 0.3 0.0 0.1 0.1 30.5 88.8 0.2 0.0 0.0 2.3 2.2 0.3 2.3 0.0 0.0 0.8 0.3 0.0 0.0 0.0 0.0 0.0 15.1 0.0 53.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 2.4 1.9 2.4 2.5 4.2 2.7 2.2 3.3 1.6 4.3 1.6 0.1 67.3 19.6 6.2 0.5 6.8 6.6 13.1 10.2 0.0 9.7 4.2 0.5 50.1 15.0 33.1 0.0 23.4 0.1 49.3 0.0 14.7 0.1 0.0 0.0 0.3 24.7 2.7 17.9 15.6 3.3 0.3 54.6 0.0 0.0 0.1 1.8 76.9 1.9 0.0 19.6 33.3 2.0 2.7 0.4 0.2 0.0 0.4 3.6 3.7 0.0 0.0 0.0 25.1 13.8 25.6 23.6 0.0 0.0 1.9 85.4 25.3 8.7 0.0 0.0 0.0 1.3 0.0 2.0 11.5 5.3 16.6 0.2 0.5 28.7 8.5 RNF13 RZF ENSG00000082996 "Ring finger protein 13" O43567 3 149812770-149962139 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 591.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 462.3" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA064784 Approved Supported Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 21: Non-specific - Transcription" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 4: Macrophages - Innate immune response" "Nucleoplasm, Vesicles" Cytosol "HPA064784: AB_2685350" "unprognostic (1.27e-1)" "unprognostic (2.32e-2)" "unprognostic (1.03e-1)" "unprognostic (1.93e-2)" "unprognostic (1.80e-1)" "unprognostic (9.64e-2)" "unprognostic (8.49e-2)" "unprognostic (4.36e-3)" "unprognostic (1.72e-1)" "unprognostic (1.25e-1)" "unprognostic (6.94e-3)" "unprognostic (1.13e-1)" "prognostic favorable (2.00e-8)" "unprognostic (2.95e-1)" "unprognostic (4.11e-2)" "unprognostic (2.17e-1)" "unprognostic (1.79e-1)" 48.2 41.2 58.1 40.4 95.2 19.9 53.9 88.1 91.5 33.6 63.7 35.0 28.9 33.3 57.2 32.6 30.2 40.6 34.4 55.0 77.3 67.9 73.8 64.1 38.0 101.8 83.9 35.6 36.1 52.3 18.3 64.1 100.8 46.6 37.1 40.4 75.5 39.3 36.5 32.5 30.5 36.9 85.6 53.0 34.3 25.2 75.9 32.0 64.0 42.6 33.2 42.3 28.9 131.0 60.6 39.4 24.4 29.0 92.2 55.2 40.3 32.2 86.2 32.3 47.4 33.4 84.4 26.6 48.7 42.0 58.7 58.0 37.5 41.5 42.9 34.1 24.6 35.8 17.3 31.2 61.5 35.0 41.8 59.9 73.1 26.5 71.8 37.3 37.0 24.9 10.1 49.7 28.0 34.5 26.2 18.8 16.8 58.6 29.1 19.0 26.7 108.5 54.2 29.6 12.6 37.6 28.5 39.9 110.3 19.2 79.2 34.0 37.8 40.8 16.5 45.6 23.4 89.9 61.9 51.5 35.9 30.1 23.6 98.2 130.1 106.5 37.4 153.8 48.8 51.9 41.5 44.8 93.1 48.4 38.0 42.4 462.3 46.3 207.8 68.3 48.7 104.5 58.1 95.2 88.1 91.5 55.0 77.3 101.8 83.9 100.8 85.6 75.9 131.0 100.9 109.0 72.3 78.7 55.3 73.5 68.2 84.3 74.0 44.5 54.5 51.1 27.3 48.6 68.1 47.8 29.2 101.2 61.9 30.2 43.0 63.0 2.5 32.5 34.5 69.4 20.3 32.4 122.1 70.6 83.5 84.8 31.6 39.7 60.8 14.6 80.3 53.7 201.2 21.9 98.8 27.7 67.1 183.9 173.7 6.7 76.1 177.6 103.2 92.8 93.5 98.5 38.1 115.6 591.2 58.7 33.6 88.0 62.4 71.9 38.5 71.5 40.4 37.2 92.1 76.3 55.5 23.6 32.5 52.3 72.5 52.5 49.8 38.2 27.7 55.8 RNF130 "G1RZFP, GOLIATH, GP" ENSG00000113269 "Ring finger protein 130" Q86XS8 5 179911651-180072113 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Apoptosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hofbauer cells: 295.7;Kupffer cells: 393.7;Macrophages: 283.0;monocytes: 276.4;Oligodendrocytes: 514.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 8 "basophil: 261.6;classical monocyte: 513.2;eosinophil: 331.3;intermediate monocyte: 355.0;myeloid DC: 407.4;neutrophil: 890.5;non-classical monocyte: 328.7;plasmacytoid DC: 317.2" "Group enriched" "Detected in all" 11 "dendritic cells: 407.4;granulocytes: 890.5;monocytes: 513.2" "Cell line enhanced" "Detected in many" "HMC-1: 179.3" "Low region specificity" "Detected in all" HPA014499 Approved NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 15: Liver - Metabolism" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 10: Non-specific - Unknown function" "HPA014499: AB_1856328" "unprognostic (2.01e-1)" "prognostic favorable (6.32e-4)" "unprognostic (2.43e-1)" "unprognostic (1.37e-1)" "unprognostic (2.24e-1)" "unprognostic (1.62e-2)" "unprognostic (2.83e-1)" "unprognostic (2.02e-3)" "unprognostic (2.93e-2)" "unprognostic (1.78e-1)" "unprognostic (4.00e-2)" "unprognostic (2.81e-1)" "unprognostic (1.14e-1)" "unprognostic (8.41e-2)" "unprognostic (4.17e-2)" "unprognostic (4.32e-1)" "unprognostic (1.38e-2)" 94.2 43.4 79.7 47.7 103.2 94.0 50.2 102.3 114.1 55.5 75.5 40.1 28.1 42.1 35.6 26.4 46.8 55.9 36.2 81.4 85.8 49.4 167.1 62.6 39.2 112.8 94.6 52.2 64.2 28.0 16.6 48.4 110.6 35.1 41.9 14.3 84.6 60.2 33.2 14.6 32.6 52.6 98.4 51.8 34.7 17.5 92.3 17.7 32.3 53.7 25.8 51.6 19.3 138.2 32.7 26.8 125.5 110.9 117.4 54.5 21.9 20.9 29.1 24.1 25.3 8.4 31.8 0.1 69.6 47.5 47.7 3.0 81.5 49.7 26.0 0.3 54.6 57.7 11.8 25.4 27.3 14.9 179.3 52.2 25.9 2.3 15.3 65.6 42.3 57.3 9.7 0.4 27.0 71.0 28.7 68.8 32.7 6.7 33.8 65.9 27.9 0.1 38.7 7.4 68.4 28.8 43.2 34.4 126.5 45.7 40.8 38.6 36.6 50.6 18.9 38.8 27.1 0.4 24.1 6.2 7.7 132.0 41.2 261.6 513.2 331.3 25.4 355.0 21.7 15.8 10.9 12.3 407.4 15.8 12.4 13.6 890.5 53.6 328.7 317.2 1.6 323.8 79.7 103.2 102.3 114.1 81.4 85.8 112.8 94.6 110.6 98.4 92.3 138.2 75.0 19.2 21.4 119.1 22.4 14.1 22.6 27.0 12.5 26.9 55.0 45.5 35.1 81.5 34.7 42.3 52.1 11.2 123.7 26.9 23.5 56.8 11.8 49.0 38.8 48.3 16.3 69.2 119.0 76.5 16.6 57.9 25.5 38.3 82.9 28.9 47.5 147.0 295.7 6.7 144.0 36.1 36.7 393.7 170.7 24.2 36.7 283.0 32.0 141.5 276.4 21.8 28.8 242.8 514.2 41.6 32.1 48.2 11.7 27.2 32.6 52.0 56.3 20.3 46.0 32.4 48.5 13.2 32.9 10.9 12.9 8.8 26.2 33.7 52.9 23.3 RNF133 ENSG00000188050 "Ring finger protein 133" Q8WVZ7 7 122697735-122699117 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 6 "testis: 42.2" "Group enriched" "Detected in some" 146 "Early spermatids: 479.8;Late spermatids: 837.4" "Not detected" "Not detected" "Region enriched" "Detected in some" 5 "cerebellum: 7.0" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 31: Spermatids - Spermatogenesis" "unprognostic (2.82e-1)" "unprognostic (2.52e-2)" "unprognostic (1.77e-1)" "unprognostic (3.04e-2)" "unprognostic (2.45e-3)" "unprognostic (1.67e-1)" "unprognostic (8.87e-3)" "unprognostic (3.56e-2)" "unprognostic (3.72e-1)" "unprognostic (3.29e-3)" "unprognostic (1.26e-1)" "unprognostic (1.02e-2)" "unprognostic (7.76e-2)" "unprognostic (1.10e-1)" "unprognostic (2.39e-1)" "unprognostic (2.37e-2)" "unprognostic (7.61e-2)" 0.2 0.1 0.0 0.0 0.1 0.0 0.2 7.0 1.3 0.2 0.1 0.0 0.0 0.8 0.1 0.0 0.2 0.1 0.1 0.1 0.1 0.2 0.1 0.3 0.0 0.0 0.2 0.1 0.2 0.0 0.1 0.0 0.4 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 42.2 0.2 0.0 0.2 0.0 0.0 0.1 0.1 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.3 0.0 0.0 0.2 0.1 0.2 0.0 0.0 0.2 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 7.0 1.3 0.1 0.1 0.0 0.2 0.4 0.0 0.2 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 479.8 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 837.4 2.8 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.5 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.1 RNF135 MGC13061 ENSG00000181481 "Ring finger protein 135" Q8IUD6 17 30970984-30999911 "Enzymes, Human disease related genes, Predicted intracellular proteins" "Immunity, Innate immunity, Ubl conjugation pathway" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Kupffer cells: 73.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "hTCEpi: 63.3" "Low region specificity" "Detected in all" "HPA021576, HPA052404" Approved Approved Vesicles NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 31: Skin - Epidermis development" "Cluster 30: Epithelial cell lines - Translation" "Cluster 4: Macrophages - Innate immune response" Vesicles "HPA021576: AB_1856331, HPA052404: AB_2681817" "unprognostic (1.13e-1)" "unprognostic (1.87e-2)" "unprognostic (6.24e-2)" "unprognostic (2.33e-2)" "unprognostic (2.68e-2)" "unprognostic (3.51e-3)" "unprognostic (1.57e-1)" "unprognostic (1.24e-1)" "unprognostic (4.60e-2)" "unprognostic (4.16e-1)" "unprognostic (1.35e-2)" "unprognostic (2.06e-1)" "prognostic unfavorable (7.51e-5)" "unprognostic (6.44e-2)" "unprognostic (1.54e-1)" "unprognostic (2.42e-1)" "unprognostic (4.47e-1)" 20.9 12.9 11.1 13.5 12.5 11.6 18.6 11.2 14.2 16.0 15.1 17.5 13.6 13.3 16.5 22.4 15.7 9.6 8.5 10.4 11.3 21.6 8.6 15.5 13.9 13.9 13.2 12.6 13.5 16.8 5.6 18.1 12.4 14.0 18.0 2.3 15.2 15.2 7.4 26.2 13.9 13.7 12.8 25.8 11.9 5.1 16.4 7.9 15.8 10.1 12.6 14.8 17.3 13.8 12.7 25.6 1.5 25.4 34.0 28.5 22.7 9.7 14.9 9.4 8.4 0.0 9.4 11.5 14.8 19.0 17.0 17.0 13.2 12.1 7.8 10.0 5.6 4.8 8.1 0.0 24.3 12.8 10.7 27.7 63.3 10.1 33.5 16.1 15.8 0.0 0.0 34.9 15.6 17.0 0.1 13.5 10.5 25.7 14.4 27.9 0.0 39.2 13.6 18.2 9.8 0.5 14.9 5.9 14.9 16.6 39.4 20.2 13.3 0.0 3.5 15.6 11.5 0.4 1.3 7.3 16.5 22.1 13.3 25.3 61.6 31.3 12.8 57.3 7.2 28.4 6.8 6.8 46.4 28.4 3.7 6.2 54.0 13.9 70.2 17.1 10.1 29.2 11.1 12.5 11.2 14.2 10.4 11.3 13.9 13.2 12.4 12.8 16.4 13.8 14.1 3.2 5.9 7.8 14.1 9.3 13.4 16.8 22.2 0.1 13.1 15.0 4.0 7.2 7.8 11.0 0.0 47.5 10.5 23.4 29.4 9.9 0.4 14.5 12.8 13.2 4.9 11.2 0.8 18.6 37.1 13.2 5.6 12.4 1.3 14.1 25.4 2.7 51.1 0.0 1.0 12.0 8.2 73.9 8.4 1.6 16.8 35.5 16.0 26.2 45.3 3.9 19.6 9.0 0.7 11.9 13.1 15.4 9.0 22.2 27.5 49.3 10.4 0.6 26.3 8.2 14.2 0.7 4.0 24.1 14.6 43.6 7.5 10.6 14.6 11.2 RNF138 "NARF, STRIN" ENSG00000134758 "Ring finger protein 138" Q8WVD3 18 32091874-32131561 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway, Wnt signaling pathway" "DNA-binding, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 96.0;testis: 119.3" "Group enriched" "Detected in many" 15 "Early spermatids: 982.8;Late spermatids: 3827.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041101 Approved Mitochondria NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 25: Spermatids - Spermatogenesis" Mitochondria "HPA041101: AB_10805837" "unprognostic (2.37e-2)" "unprognostic (4.63e-3)" "unprognostic (2.03e-3)" "unprognostic (1.01e-1)" "unprognostic (2.34e-1)" "unprognostic (2.93e-2)" "unprognostic (1.47e-2)" "unprognostic (9.64e-2)" "unprognostic (1.29e-2)" "unprognostic (1.90e-2)" "unprognostic (6.90e-2)" "unprognostic (1.27e-2)" "unprognostic (6.15e-2)" "unprognostic (9.52e-3)" "unprognostic (2.77e-1)" "unprognostic (9.58e-2)" "unprognostic (1.90e-1)" 13.7 7.3 7.6 17.4 9.3 96.0 14.5 13.8 11.9 12.4 10.7 23.5 16.7 14.3 8.5 14.9 19.4 13.6 5.9 6.9 8.7 9.7 21.6 13.3 24.2 8.0 8.6 14.9 16.4 11.2 7.5 15.3 8.5 10.5 20.2 8.9 9.9 7.9 6.9 8.8 17.3 11.6 8.3 21.6 14.2 119.3 8.2 28.9 11.8 6.8 19.8 13.3 8.6 12.4 28.3 16.4 66.4 33.2 8.5 17.5 37.6 28.3 15.8 34.7 39.8 19.4 19.3 67.9 34.3 18.6 22.3 28.9 35.1 31.9 47.1 37.7 58.8 53.5 19.2 24.1 33.3 149.3 45.3 17.1 31.3 38.3 53.8 19.9 35.9 59.3 74.7 27.0 22.7 26.6 101.1 66.5 74.4 48.4 22.6 102.5 41.7 39.3 31.9 20.7 75.0 37.5 37.7 21.7 30.1 30.2 14.0 62.2 27.8 41.5 30.5 10.3 32.2 44.4 64.5 117.9 22.6 81.6 41.5 25.0 64.4 63.3 25.0 48.7 32.2 34.6 54.5 35.9 62.5 39.2 102.8 66.9 64.7 42.8 42.0 26.6 44.3 68.3 7.6 9.3 13.8 11.9 6.9 8.7 8.0 8.6 8.5 8.3 8.2 12.4 27.9 16.0 19.7 15.3 65.9 69.3 33.7 11.8 71.2 6.7 32.4 18.0 8.3 24.3 16.8 16.5 0.0 28.3 51.6 43.0 17.6 17.6 982.8 35.6 20.4 29.4 29.9 48.8 25.9 18.4 21.6 21.3 26.0 28.7 22.8 8.4 22.5 16.8 24.8 8.4 28.0 20.8 20.3 25.5 52.3 3827.9 29.5 34.7 26.6 23.4 27.1 9.9 20.6 22.6 36.4 12.9 23.9 22.2 32.4 32.7 16.4 14.5 23.0 5.2 32.9 23.1 26.0 158.1 128.3 51.4 52.1 8.9 59.3 9.9 29.9 37.5 RNF139 "HRCA1, RCA1, TRC8" ENSG00000170881 "Ring finger protein 139" Q8WU17 8 124474880-124488618 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Ubl conjugation pathway" "Receptor, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 93.2" "Group enriched" "Detected in all" 10 "Early spermatids: 810.1;Late spermatids: 992.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA001202 Approved NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 34: Spermatids - Unknown function" "HPA001202: AB_1079824" "unprognostic (3.28e-3)" "unprognostic (2.92e-2)" "unprognostic (5.16e-2)" "unprognostic (5.43e-2)" "unprognostic (1.03e-1)" "unprognostic (8.32e-3)" "unprognostic (2.71e-2)" "unprognostic (2.00e-1)" "unprognostic (1.69e-1)" "unprognostic (1.51e-1)" "prognostic unfavorable (3.54e-4)" "unprognostic (9.85e-2)" "unprognostic (1.53e-2)" "unprognostic (1.62e-1)" "unprognostic (2.75e-1)" "unprognostic (7.75e-2)" "unprognostic (1.45e-1)" 23.5 20.8 10.0 15.9 11.1 93.2 18.9 14.8 12.7 16.6 11.2 15.6 9.2 20.2 13.6 16.5 16.7 16.8 15.3 11.0 11.0 15.3 26.1 16.6 17.3 11.0 10.8 23.6 14.4 11.8 10.2 19.4 11.0 14.9 14.8 12.4 16.5 13.3 20.3 17.2 14.2 20.3 11.8 13.9 13.9 68.7 11.7 19.3 16.3 22.6 14.8 16.7 12.4 15.0 26.6 17.1 21.6 20.3 43.2 34.1 16.6 23.5 44.4 18.6 24.7 10.9 21.6 27.5 27.8 31.7 14.3 19.7 18.3 28.4 28.9 37.6 24.5 41.1 11.9 22.9 33.3 19.6 23.2 30.5 41.0 20.5 55.9 27.1 26.2 26.8 29.1 41.3 22.2 70.2 32.9 13.6 14.3 52.6 25.6 13.2 14.9 27.0 35.3 34.4 9.4 22.3 31.0 76.5 33.4 16.5 35.7 20.7 20.6 13.9 29.7 22.2 26.3 32.9 40.9 28.6 19.9 31.7 13.9 2.7 6.2 10.1 8.7 4.1 11.0 7.9 7.8 10.5 8.4 7.1 8.1 8.4 8.5 7.2 11.4 4.0 11.4 6.7 10.0 11.1 14.8 12.7 11.0 11.0 11.0 10.8 11.0 11.8 11.7 15.0 21.1 3.2 8.4 11.8 66.2 66.2 62.1 27.2 58.6 14.5 31.6 19.7 16.2 34.3 18.5 22.0 6.2 42.3 58.5 22.5 11.7 19.9 810.1 31.3 22.6 24.9 21.7 27.1 12.9 18.0 55.9 40.1 23.4 37.1 20.3 23.2 22.9 31.8 25.0 16.8 12.8 18.5 10.2 33.7 74.4 992.2 29.5 43.4 35.6 12.2 26.5 21.3 26.8 8.5 18.5 22.5 11.4 27.1 35.4 41.1 17.0 16.9 20.1 22.7 19.7 39.7 49.2 62.3 24.3 46.7 70.5 75.5 83.5 22.6 18.2 55.5 RNF14 "ARA54, HFB30, TRIAD2" ENSG00000013561 "Ring finger protein 14" Q9UBS8 5 141958328-141990292 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 257.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008716, HPA064746" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 34: Basophils - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 23: Spermatids - Flagellum & Golgi organization" Nucleoplasm Cytosol "HPA008716: AB_1856337, HPA064746: " "unprognostic (7.45e-3)" "unprognostic (1.38e-1)" "unprognostic (8.56e-2)" "unprognostic (1.20e-1)" "unprognostic (3.47e-2)" "unprognostic (7.24e-3)" "unprognostic (2.35e-1)" "unprognostic (4.05e-2)" "unprognostic (5.22e-2)" "unprognostic (7.42e-2)" "unprognostic (7.92e-2)" "unprognostic (1.46e-1)" "prognostic favorable (1.71e-4)" "unprognostic (6.89e-3)" "unprognostic (2.82e-1)" "prognostic unfavorable (2.21e-4)" "unprognostic (1.06e-2)" 48.4 51.8 31.5 26.0 32.7 20.2 45.6 32.7 42.8 36.6 30.6 40.7 33.2 33.6 43.2 32.6 29.7 32.6 71.2 33.3 35.6 65.3 67.6 30.2 32.3 35.3 38.2 32.3 37.2 104.0 23.7 39.8 36.3 44.0 41.2 40.4 37.1 40.2 66.7 23.5 36.4 43.3 33.4 28.9 35.4 74.5 36.5 36.7 55.1 85.8 33.7 32.1 23.4 33.7 38.3 62.5 43.1 85.1 75.7 78.8 29.0 76.8 42.6 52.8 58.1 52.4 43.4 67.1 87.5 79.3 79.4 20.6 55.6 75.4 47.0 51.1 48.5 42.9 30.2 24.0 83.2 47.7 36.9 59.7 64.9 70.3 87.6 45.6 66.2 46.0 53.0 91.7 109.4 45.7 46.6 15.3 18.3 46.2 71.0 30.2 47.8 73.8 71.7 65.2 47.5 38.3 67.3 121.3 133.2 47.8 85.0 36.7 69.3 69.6 22.6 33.2 74.0 56.8 72.1 61.8 59.7 57.4 87.9 79.6 22.0 23.2 26.9 26.9 26.0 19.5 23.2 26.9 27.4 18.1 17.6 25.9 5.5 30.1 33.9 28.9 29.1 19.7 31.5 32.7 32.7 42.8 33.3 35.6 35.3 38.2 36.3 33.4 36.5 33.7 18.1 9.6 19.3 12.7 12.5 10.7 15.9 19.6 11.4 20.2 18.4 15.0 45.4 11.5 18.1 22.0 16.7 29.1 13.3 22.9 68.4 29.2 257.1 14.1 20.8 21.7 15.0 59.1 25.1 24.9 26.1 18.2 18.3 16.4 22.2 32.0 20.7 33.1 24.5 23.5 22.9 14.9 24.4 29.7 10.4 39.3 19.3 17.1 32.0 13.1 14.8 28.7 29.9 15.6 18.6 26.3 14.0 33.4 13.5 19.2 28.3 50.5 15.8 16.3 39.5 15.8 23.0 38.7 25.8 15.6 10.5 60.5 16.4 25.0 15.0 15.0 RNF144A "hUIP4, KIAA0161, RNF144, UBCE7IP4" ENSG00000151692 "Ring finger protein 144A" P50876 2 6917412-7068286 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 73.6" "Cell type enhanced" "Detected in many" "Excitatory neurons: 176.6;Inhibitory neurons: 101.7;Oligodendrocyte precursor cells: 194.5;Oligodendrocytes: 330.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "eosinophil: 6.1" "Group enriched" "Detected in many" 7 "granulocytes: 6.1;T-cells: 2.4" "Cell line enhanced" "Detected in many" "HEL: 39.7;HMC-1: 127.9;SH-SY5Y: 39.0;SK-MEL-30: 39.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049939 Approved Supported Vesicles NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 3: HMC-1 - Innate immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Vesicles "HPA049939: AB_2680960" "unprognostic (1.78e-1)" "unprognostic (2.53e-3)" "unprognostic (8.37e-2)" "prognostic unfavorable (6.00e-4)" "unprognostic (6.57e-2)" "prognostic favorable (6.96e-4)" "unprognostic (7.04e-6)" "unprognostic (1.20e-1)" "unprognostic (2.03e-2)" "unprognostic (5.64e-1)" "unprognostic (9.11e-2)" "unprognostic (1.92e-1)" "unprognostic (1.03e-1)" "prognostic unfavorable (7.32e-5)" "unprognostic (1.30e-2)" "unprognostic (3.01e-1)" "unprognostic (1.82e-3)" 9.7 28.5 21.1 4.1 46.1 13.9 10.1 59.2 36.7 24.2 1.2 5.7 2.6 26.3 7.7 4.3 7.8 7.1 8.1 17.5 24.0 7.3 1.3 5.4 6.0 30.1 27.0 19.3 30.7 38.1 12.9 5.9 33.4 9.1 5.3 23.0 4.6 6.4 9.6 5.4 3.8 11.6 21.5 23.0 2.6 4.7 30.3 7.5 3.4 10.1 5.6 4.4 7.5 73.6 0.8 5.8 30.1 6.2 6.6 13.6 23.0 0.2 0.0 1.1 2.8 0.1 0.7 2.9 3.3 0.3 8.7 0.7 10.0 0.0 0.0 1.6 2.6 39.7 0.3 11.8 0.3 0.7 127.9 21.7 0.1 2.2 0.0 0.0 0.0 9.9 17.3 0.6 0.0 4.9 20.6 1.7 11.0 0.7 13.6 15.9 21.8 2.6 1.0 10.2 9.9 39.0 0.5 4.0 39.8 3.9 1.7 2.6 0.1 3.9 10.0 10.7 4.5 10.4 3.5 0.1 14.7 8.7 14.3 1.3 0.0 6.1 1.2 0.0 1.8 0.0 1.3 0.9 0.1 0.1 2.4 1.7 0.3 0.5 0.0 0.0 0.6 0.4 21.1 46.1 59.2 36.7 17.5 24.0 30.1 27.0 33.4 21.5 30.3 73.6 27.8 3.2 4.2 34.3 2.4 2.4 0.7 0.0 1.8 4.6 2.5 2.5 11.5 2.8 1.9 0.0 75.0 2.4 5.3 15.4 1.9 3.3 5.5 6.1 15.4 13.9 25.4 18.5 176.6 5.8 3.1 10.4 2.6 10.7 8.9 31.5 23.2 1.1 4.9 10.1 101.7 2.7 0.0 1.0 1.7 14.2 4.4 1.7 24.9 17.8 1.2 7.6 10.3 194.5 330.3 3.0 11.1 10.5 3.1 3.0 2.0 0.3 1.5 39.8 0.0 16.1 5.2 1.8 6.6 5.2 1.6 1.1 9.8 19.1 2.7 1.7 RNF144B "bA528A10.3, IBRDC2, P53RFP" ENSG00000137393 "Ring finger protein 144B" Q7Z419 6 18387350-18468870 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Apoptosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 56.9" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 634.4;Langerhans cells: 296.9;Suprabasal keratinocytes: 1501.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "non-classical monocyte: 71.9" "Group enriched" "Detected in many" 9 "dendritic cells: 18.4;granulocytes: 36.7;monocytes: 71.9" "Cell line enhanced" "Detected in many" "Daudi: 192.8;hTCEpi: 59.1;HUVEC TERT2: 55.6;TIME: 56.1;U-698: 160.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB046013, HPA054127, HPA072469" Uncertain Approved Nucleoli,Mitochondria NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 59: Non-specific - Translation" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 41: Macrophages - Immune response" Nucleoli Mitochondria "CAB046013: AB_11126028, HPA054127: AB_2682391, HPA072469: " "unprognostic (2.24e-2)" "unprognostic (1.16e-1)" "unprognostic (1.56e-1)" "unprognostic (4.07e-2)" "unprognostic (2.55e-1)" "unprognostic (4.48e-3)" "unprognostic (5.89e-2)" "unprognostic (1.18e-2)" "unprognostic (6.55e-2)" "unprognostic (2.87e-3)" "unprognostic (2.44e-2)" "unprognostic (2.60e-1)" "unprognostic (1.34e-1)" "unprognostic (2.39e-1)" "unprognostic (3.91e-2)" "unprognostic (1.53e-1)" "unprognostic (1.21e-1)" 9.4 2.0 7.4 15.6 7.4 24.0 29.1 7.9 9.0 9.5 9.1 4.2 1.8 5.7 4.7 8.4 11.8 6.2 8.1 6.4 7.7 14.0 15.5 19.4 11.3 11.8 11.9 1.6 3.2 2.9 1.7 15.1 9.4 13.1 2.8 5.0 16.9 7.3 56.9 21.1 3.3 6.2 8.9 13.1 5.7 2.3 10.5 5.1 40.9 14.1 12.9 9.4 7.1 8.7 4.6 1.0 0.4 0.0 0.3 2.0 9.8 5.3 5.7 11.0 11.8 0.1 0.4 192.8 50.7 2.3 0.6 16.3 0.1 16.0 15.5 0.9 1.4 0.2 0.2 4.2 0.2 0.2 0.2 2.7 59.1 4.3 13.2 4.9 55.6 4.3 0.1 0.0 2.7 2.0 1.5 0.0 1.6 0.6 1.1 0.7 1.7 11.8 33.2 10.6 1.9 0.2 1.2 23.9 18.5 1.5 28.2 0.5 56.1 8.6 1.9 0.8 1.2 0.0 0.1 160.6 1.0 0.4 0.7 0.4 20.7 12.9 0.5 38.9 1.6 4.6 0.8 0.6 13.3 3.6 1.6 1.0 36.7 0.6 71.9 18.4 0.5 7.1 7.4 7.4 7.9 9.0 6.4 7.7 11.8 11.9 9.4 8.9 10.5 8.7 28.8 44.8 15.0 34.9 21.7 634.4 48.8 86.0 14.8 0.9 35.7 26.3 12.8 17.2 48.3 38.6 2.1 14.1 9.8 2.2 19.6 8.6 2.1 49.0 5.8 34.6 1.2 3.8 2.3 8.9 3.7 7.8 10.7 58.5 3.8 0.1 47.2 21.9 15.0 0.0 99.0 1.8 14.2 109.4 296.9 1.8 1.2 171.7 60.5 92.8 54.1 17.9 1.0 3.5 2.5 5.2 3.6 3.0 3.4 112.3 0.9 20.6 36.7 1.2 0.0 9.0 7.8 2.2 3.2 30.0 1501.1 1.5 4.9 0.1 2.3 42.6 RNF145 FLJ31951 ENSG00000145860 "Ring finger protein 145" Q96MT1 5 159157409-159210053 "Enzymes, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Group enriched" "Detected in all" 4 "B-cells: 11.4;granulocytes: 16.0;T-cells: 6.3" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036562 Uncertain Approved "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 37: B-cells - Transcription" "Cluster 28: Placenta - Pregnancy" "Cluster 12: NES - Nervous system development" "Cluster 41: Macrophages - Immune response" "Nucleoplasm, Plasma membrane, Cytosol" "HPA036562: AB_10696657" "unprognostic (1.57e-1)" "unprognostic (9.02e-3)" "unprognostic (4.11e-2)" "unprognostic (3.88e-2)" "unprognostic (3.24e-2)" "unprognostic (2.93e-2)" "prognostic unfavorable (1.64e-6)" "unprognostic (1.35e-1)" "unprognostic (1.02e-2)" "unprognostic (1.54e-1)" "unprognostic (3.53e-1)" "unprognostic (1.67e-1)" "unprognostic (8.92e-3)" "unprognostic (1.49e-1)" "unprognostic (1.00e-1)" "unprognostic (1.10e-1)" "unprognostic (1.39e-1)" 27.4 39.3 13.7 39.4 15.9 20.4 28.2 16.2 16.1 24.7 18.6 26.4 12.2 21.0 30.9 53.1 16.9 48.3 18.8 15.6 19.8 19.5 15.3 73.6 38.7 11.1 13.1 29.0 12.3 47.7 19.4 52.4 11.6 25.9 29.3 33.8 25.6 32.7 9.0 22.3 16.6 27.4 14.3 29.2 26.7 12.1 20.3 26.5 33.8 13.7 48.4 68.1 24.4 14.7 65.5 63.5 95.2 115.1 98.5 43.6 18.6 51.3 88.9 46.3 74.6 22.2 52.9 22.4 89.7 45.3 87.9 83.1 75.9 67.3 80.9 92.7 27.2 47.2 68.5 18.4 42.1 31.4 43.2 27.0 118.8 43.2 63.0 64.7 46.2 53.6 47.7 83.6 44.1 1.9 36.1 9.8 41.3 20.5 32.0 47.3 41.6 44.8 61.4 22.3 34.5 63.9 51.8 54.7 86.5 64.7 38.5 28.4 49.7 51.6 47.0 41.9 92.1 18.4 27.6 20.6 60.3 38.4 113.1 3.5 2.5 16.0 3.0 2.6 3.5 11.4 4.4 3.6 1.9 5.1 5.8 4.0 9.5 2.3 2.3 2.7 6.3 1.3 13.7 15.9 16.2 16.1 15.6 19.8 11.1 13.1 11.6 14.3 20.3 14.7 34.1 112.2 244.1 25.1 62.9 122.7 102.0 90.0 73.4 106.7 97.2 77.3 12.7 65.8 114.0 36.8 58.4 2.8 55.1 98.4 19.6 75.0 28.9 27.5 37.1 75.7 54.1 67.5 89.2 114.4 24.3 45.7 52.0 36.7 69.1 30.2 127.8 19.5 45.5 114.4 74.2 41.8 32.6 115.0 240.8 39.5 46.3 69.4 65.8 52.5 153.9 56.1 47.4 40.2 38.9 108.6 53.7 51.9 38.1 123.8 16.9 10.6 65.6 53.4 46.0 25.4 46.5 19.2 34.8 81.9 99.4 10.9 69.3 19.0 72.0 163.1 RNF146 "dactylidin, dJ351K20.1, DKFZp434O1427" ENSG00000118518 "Ring finger protein 146" Q9NTX7 6 127266682-127288567 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway, Wnt signaling pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027158, HPA027209" Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" No No "Cluster 14: Monocytes - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 50: Fibroblasts - ECM organization" "Plasma membrane, Cytosol" Nucleoplasm "HPA027158: AB_10600772, HPA027209: AB_10602312" "unprognostic (8.22e-2)" "unprognostic (1.20e-2)" "unprognostic (1.21e-1)" "unprognostic (1.32e-1)" "unprognostic (1.38e-2)" "unprognostic (1.17e-2)" "unprognostic (1.37e-1)" "unprognostic (5.47e-3)" "unprognostic (1.87e-1)" "unprognostic (6.74e-2)" "prognostic favorable (5.26e-5)" "unprognostic (2.65e-2)" "prognostic favorable (7.32e-4)" "unprognostic (4.04e-2)" "unprognostic (1.29e-1)" "unprognostic (6.13e-2)" "unprognostic (2.15e-2)" 52.9 37.0 49.5 32.4 56.0 10.6 42.7 79.4 61.2 48.1 36.2 40.5 21.9 57.4 60.8 25.3 42.4 38.6 46.9 50.7 51.6 37.1 31.8 38.7 35.1 53.2 52.1 49.5 23.3 40.0 33.3 51.8 56.8 31.7 30.9 48.1 31.2 34.5 114.9 29.5 31.1 45.9 55.2 47.1 29.9 31.3 52.5 24.3 47.1 91.5 33.3 36.9 34.3 61.5 13.2 16.2 60.3 53.6 54.7 54.3 22.2 43.5 69.0 22.8 32.4 21.3 19.3 23.6 30.3 35.7 36.2 16.4 18.1 20.4 32.9 27.6 16.0 30.3 21.8 30.0 54.0 18.0 20.6 47.6 42.1 26.1 51.1 52.5 40.6 23.2 33.0 22.5 50.7 25.2 17.9 32.0 22.1 8.1 17.1 22.6 15.7 12.1 32.4 14.3 36.0 36.6 17.1 23.6 27.7 35.5 16.1 60.8 48.3 39.7 13.1 41.8 31.7 32.3 22.0 15.6 30.5 31.0 38.5 27.5 30.0 26.6 14.3 32.4 14.7 17.4 12.2 16.3 22.8 17.9 11.0 15.5 37.0 19.8 40.1 11.7 15.0 16.1 49.5 56.0 79.4 61.2 50.7 51.6 53.2 52.1 56.8 55.2 52.5 61.5 24.6 35.3 29.3 35.6 23.7 17.7 14.3 15.1 18.8 34.7 16.9 14.7 38.9 31.5 16.7 9.2 4.2 29.0 14.7 13.5 41.1 28.0 52.5 15.7 29.5 30.5 20.4 12.8 53.5 15.8 27.2 50.6 7.1 11.5 22.2 28.1 31.4 30.5 26.3 30.3 54.5 12.1 38.7 68.4 24.6 45.4 69.6 29.9 46.2 42.2 31.1 41.1 28.8 56.3 76.5 18.0 17.0 66.5 9.3 26.3 15.7 51.7 23.9 20.9 32.9 36.2 31.9 41.7 24.9 15.0 20.0 38.4 20.8 36.0 10.9 25.9 RNF149 FLJ90504 ENSG00000163162 "Ring finger protein 149" Q8NC42 2 101271219-101308701 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Kupffer cells: 278.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in all" 5 "neutrophil: 619.9" "Lineage enriched" "Detected in all" 5 "granulocytes: 619.9" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA011424 Approved Approved "Vesicles,Plasma membrane" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 19: Monocytes & Neutrophils - Innate immune response" "Vesicles, Plasma membrane" "HPA011424: AB_1079825" "unprognostic (2.56e-2)" "unprognostic (4.70e-2)" "unprognostic (1.96e-1)" "unprognostic (3.49e-2)" "unprognostic (3.17e-2)" "unprognostic (5.17e-3)" "unprognostic (4.16e-2)" "unprognostic (4.77e-3)" "unprognostic (5.61e-2)" "unprognostic (1.43e-2)" "unprognostic (5.69e-3)" "unprognostic (1.51e-1)" "prognostic unfavorable (2.04e-8)" "unprognostic (1.39e-1)" "unprognostic (6.16e-2)" "unprognostic (2.70e-1)" "prognostic favorable (2.91e-4)" 26.7 15.2 7.7 40.3 7.5 52.3 16.3 7.7 9.7 17.7 12.3 15.7 16.8 12.4 16.3 35.5 16.9 18.9 12.5 7.6 8.9 16.3 26.6 30.5 18.3 9.9 8.5 15.9 22.3 17.9 10.4 21.8 9.6 12.6 15.8 7.8 18.3 10.1 8.5 25.6 18.2 12.9 8.5 53.1 19.1 15.8 9.1 15.2 12.2 9.4 19.6 29.1 22.7 10.9 19.9 11.4 8.8 11.3 31.6 31.3 49.7 24.0 31.8 32.1 35.8 29.0 51.6 6.1 28.3 23.9 42.9 39.0 12.5 24.6 29.7 16.9 16.6 12.4 9.9 50.0 42.1 13.4 19.2 28.9 40.0 37.9 25.1 24.7 58.9 13.0 10.7 18.0 32.4 16.9 18.8 14.0 6.1 27.1 20.0 11.5 14.2 23.4 38.0 48.0 11.5 8.5 14.4 36.0 37.2 9.5 9.7 17.8 39.6 16.2 9.1 24.5 5.3 35.5 22.5 0.2 5.2 18.6 12.2 44.0 73.6 90.3 43.8 118.1 41.8 13.2 40.0 45.3 27.9 8.5 28.2 30.2 619.9 15.3 134.1 52.5 53.8 69.8 7.7 7.5 7.7 9.7 7.6 8.9 9.9 8.5 9.6 8.5 9.1 10.9 19.9 48.1 48.1 44.7 55.2 76.9 78.1 63.5 54.7 20.4 29.7 15.9 13.0 41.5 48.4 55.2 56.3 65.2 112.4 53.1 1.9 59.1 97.9 41.8 31.9 30.0 8.5 22.7 82.8 42.2 73.0 53.5 37.2 63.1 39.2 17.3 27.1 46.2 85.9 8.4 71.6 31.7 12.2 278.6 144.2 37.2 30.7 209.0 40.9 50.6 116.5 11.6 61.8 34.7 59.6 54.3 52.3 19.5 125.5 73.5 45.9 25.8 44.8 20.7 59.2 40.5 30.1 36.6 40.3 128.3 91.6 128.1 115.7 23.8 32.8 154.1 RNF152 FLJ39176 ENSG00000176641 "Ring finger protein 152" Q8N8N0 18 61808067-61894247 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 48.3;choroid plexus: 62.3;kidney: 56.5" "Cell type enhanced" "Detected in many" "Hepatocytes: 96.4;Proximal tubular cells: 159.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HaCaT: 21.5;SH-SY5Y: 13.4;TIME: 14.2;U-138 MG: 21.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 68: Epididymis - Unknown function" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "unprognostic (3.30e-2)" "unprognostic (1.97e-2)" "unprognostic (1.64e-1)" "unprognostic (8.55e-3)" "unprognostic (2.05e-1)" "unprognostic (2.09e-1)" "unprognostic (2.96e-3)" "unprognostic (3.62e-1)" "unprognostic (1.51e-2)" "unprognostic (8.13e-2)" "unprognostic (5.14e-2)" "unprognostic (6.73e-2)" "prognostic favorable (1.13e-8)" "prognostic unfavorable (2.85e-5)" "unprognostic (3.26e-2)" "unprognostic (2.82e-2)" "unprognostic (4.83e-2)" 7.4 3.4 5.4 0.9 13.9 0.9 6.7 48.3 5.3 8.2 62.3 7.2 1.7 6.3 3.6 4.5 5.2 3.8 7.6 6.1 10.6 56.5 22.1 7.0 0.5 25.5 13.7 4.0 2.5 2.4 2.9 6.5 28.7 5.3 6.6 5.0 14.0 2.8 2.3 11.4 5.5 4.1 8.5 0.6 6.3 1.3 21.1 0.6 5.4 2.3 0.8 4.2 7.5 14.9 0.0 0.0 4.8 1.0 4.4 0.6 0.0 3.1 9.4 0.7 0.5 0.0 0.1 0.1 0.9 4.9 0.1 21.5 5.9 11.4 1.3 0.0 0.6 0.0 0.0 0.0 2.3 0.0 0.1 0.7 8.1 3.6 2.4 2.1 8.7 0.1 0.0 0.1 1.4 0.9 0.8 0.0 0.3 0.7 0.0 0.3 3.1 0.0 0.5 3.7 3.9 13.4 0.0 8.7 1.5 4.2 5.1 0.0 14.2 21.6 2.2 0.0 0.5 0.1 0.0 0.0 0.7 0.0 7.3 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 5.4 13.9 48.3 5.3 6.1 10.6 25.5 13.7 28.7 8.5 21.1 14.9 26.8 0.0 0.0 9.4 0.2 42.3 28.1 11.1 11.4 19.1 16.2 10.3 4.8 12.8 10.5 20.2 0.0 0.4 0.9 58.1 46.9 2.5 0.4 16.8 18.5 17.1 16.2 8.0 9.9 2.7 0.1 9.5 18.3 29.9 0.0 0.1 10.8 96.4 0.1 21.9 20.0 5.6 32.6 1.8 7.7 1.4 8.7 2.2 28.4 2.8 0.0 3.5 0.0 16.6 27.5 1.7 34.9 18.4 0.3 8.7 46.6 159.0 1.8 3.6 65.7 2.8 59.7 0.2 0.5 28.0 32.5 0.3 1.7 18.7 16.2 21.2 RNF157 KIAA1917 ENSG00000141576 "Ring finger protein 157" Q96PX1 17 76142465-76240493 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 4 "brain: 86.9;retina: 59.0;skeletal muscle: 73.9;testis: 31.4;tongue: 43.7" "Cell type enhanced" "Detected in many" "Bipolar cells: 114.1;Cone photoreceptor cells: 189.7;Excitatory neurons: 64.6;Horizontal cells: 180.0;Inhibitory neurons: 92.7;Rod photoreceptor cells: 70.9" "Cancer enhanced" "Detected in many" "glioma: 11.7" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in many" 5 "granulocytes: 2.2;T-cells: 5.8" "Cell line enhanced" "Detected in many" "HDLM-2: 100.9;U-266/70: 50.6;U-266/84: 45.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021854, HPA021991, HPA023922" Uncertain Approved "Golgi apparatus,Vesicles" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 54: Non-specific - Microtubule organization" "Cluster 44: HDLM-2 - Immune response" "Cluster 62: Horizontal cells - Visual perception" "Golgi apparatus" Vesicles "HPA021854: AB_10600307, HPA021991: AB_10601112, HPA023922: AB_10602202" "unprognostic (4.21e-1)" "unprognostic (4.62e-2)" "unprognostic (1.55e-2)" "unprognostic (2.63e-3)" "unprognostic (4.93e-2)" "unprognostic (5.06e-2)" "unprognostic (2.07e-3)" "unprognostic (4.21e-1)" "unprognostic (1.07e-1)" "unprognostic (2.35e-2)" "unprognostic (1.04e-3)" "unprognostic (4.02e-1)" "unprognostic (8.26e-2)" "unprognostic (8.69e-3)" "unprognostic (2.28e-1)" "unprognostic (2.75e-2)" "unprognostic (1.38e-1)" 13.6 3.3 36.4 3.7 39.1 2.2 4.9 34.1 86.9 1.4 9.8 9.8 9.6 1.4 3.4 1.0 1.8 1.3 6.4 56.9 34.5 5.8 2.5 1.4 5.2 59.7 41.9 1.2 3.4 14.6 6.3 1.6 61.1 1.9 7.0 59.0 1.9 1.5 73.9 1.0 10.3 1.8 34.1 3.5 3.9 31.4 51.5 2.8 3.4 43.7 2.7 3.0 1.0 58.1 0.2 7.1 29.3 10.7 8.8 4.4 13.4 0.3 8.9 1.9 1.3 3.3 3.1 0.0 4.2 0.5 6.9 0.2 26.0 0.1 1.6 100.9 8.9 0.0 2.9 4.7 1.7 1.4 10.9 2.4 0.1 3.7 0.1 1.5 0.2 4.7 16.0 0.3 3.6 8.0 4.4 0.8 4.8 5.5 21.1 0.0 0.3 0.1 3.4 3.2 5.1 24.0 5.3 0.1 11.5 6.5 0.7 5.1 0.2 1.9 2.3 14.4 9.6 50.6 45.5 0.1 0.8 0.1 15.1 2.2 0.2 0.3 1.6 0.1 3.4 0.2 3.4 2.7 0.1 0.4 5.8 3.9 1.2 0.7 0.2 0.3 1.3 1.0 36.4 39.1 34.1 86.9 56.9 34.5 59.7 41.9 61.1 34.1 51.5 58.1 2.8 3.2 3.3 33.3 1.5 2.0 0.8 0.2 0.6 114.1 0.8 0.9 9.0 11.5 1.3 1.8 189.7 0.6 5.0 5.3 0.0 1.9 27.8 0.6 3.7 4.4 2.4 5.5 64.6 1.1 0.4 3.1 0.0 1.5 0.0 0.9 0.7 4.3 0.4 180.0 92.7 7.4 0.0 0.8 6.0 29.1 11.5 1.1 1.8 3.7 1.4 35.9 8.2 62.8 35.0 0.1 3.4 13.9 2.1 0.9 19.3 9.1 0.7 70.9 0.0 2.9 1.3 22.7 25.0 0.0 2.3 0.3 15.5 1.3 18.2 1.5 RNF165 "Ark2C, ARKL2, RNF111L2" ENSG00000141622 "Ring finger protein 165" Q6ZSG1 18 46326809-46463140 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 7.6;retina: 18.2" "Cell type enhanced" "Detected in many" "Bipolar cells: 44.0;Cone photoreceptor cells: 100.1;Excitatory neurons: 47.4;Horizontal cells: 80.8;Inhibitory neurons: 34.4;NK-cells: 41.2;Oligodendrocyte precursor cells: 35.7;Rod photoreceptor cells: 49.1" "Low cancer specificity" "Detected in some" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in single" "NK-cell: 1.1" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in some" "AF22: 10.1;HaCaT: 7.3;HeLa: 7.5;RPMI-8226: 6.4;SCLC-21H: 13.9;SH-SY5Y: 13.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041615, HPA047798" Uncertain Approved "Nucleoplasm,Plasma membrane" NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 58: Brain - Synaptic function" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 62: Horizontal cells - Visual perception" "Nucleoplasm, Plasma membrane" "HPA041615: AB_2677582, HPA047798: AB_2680158" "unprognostic (6.46e-3)" "unprognostic (7.25e-2)" "unprognostic (4.55e-2)" "unprognostic (1.24e-5)" "unprognostic (3.43e-1)" "unprognostic (4.57e-2)" "unprognostic (5.18e-2)" "unprognostic (1.69e-1)" "unprognostic (1.04e-3)" "unprognostic (1.95e-1)" "unprognostic (1.23e-1)" "unprognostic (2.07e-1)" "unprognostic (1.87e-5)" "unprognostic (3.53e-3)" "unprognostic (1.90e-1)" "unprognostic (1.29e-1)" "unprognostic (1.64e-1)" 0.6 0.5 3.1 0.3 3.7 0.3 0.7 7.6 6.4 0.6 0.0 0.4 0.0 0.2 1.9 1.2 1.2 0.3 1.0 4.7 0.2 1.6 5.2 0.3 0.2 0.0 0.3 0.0 0.3 2.4 4.1 0.2 0.0 2.2 0.1 18.2 0.8 1.3 1.5 1.2 0.3 0.1 0.1 2.0 0.2 0.5 1.3 0.9 4.0 0.8 0.4 0.3 0.5 1.9 1.6 0.1 10.1 0.1 0.0 0.0 4.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.2 7.3 0.5 1.0 0.0 0.0 1.1 0.1 7.5 0.0 0.0 3.4 0.0 0.0 0.8 0.0 0.0 0.4 0.0 2.3 0.0 0.2 0.0 0.0 2.6 0.9 1.7 0.4 1.3 2.7 0.6 6.4 0.7 2.2 13.9 13.2 2.0 0.0 0.0 0.9 0.3 0.5 0.0 0.0 0.9 0.0 0.5 0.0 0.0 0.0 0.0 3.8 0.4 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.4 0.0 0.0 3.1 3.7 7.6 6.4 4.7 0.2 0.0 0.3 0.0 0.1 1.3 1.9 9.1 3.2 1.7 1.6 0.3 2.7 9.5 12.9 28.5 44.0 2.9 7.2 8.4 1.5 2.8 0.0 100.1 0.2 10.0 0.2 3.9 0.0 3.8 1.5 9.3 5.0 0.0 0.0 47.4 0.0 0.3 2.4 0.0 0.6 0.0 0.0 1.8 8.9 0.1 80.8 34.4 0.0 2.0 1.9 1.3 5.1 2.5 0.4 1.8 1.9 0.3 5.0 41.2 35.7 1.8 0.1 0.0 4.1 0.4 5.0 0.1 0.1 0.6 49.1 0.0 4.5 0.7 0.4 0.9 3.7 2.0 0.3 3.2 3.2 0.0 2.4 RNF166 "MGC14381, MGC2647" ENSG00000158717 "Ring finger protein 166" Q96A37 16 88696499-88706408 "Enzymes, Predicted intracellular proteins" "Autophagy, Immunity, Innate immunity, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 91.2;lymphoid tissue: 101.6" "Cell type enhanced" "Detected in all" "dendritic cells: 132.3;NK-cells: 111.2;T-cells: 73.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "NB-4: 108.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA042970 Approved "Nucleoplasm,Plasma membrane,Cytosol" No No "Cluster 45: Eosinophils - Innate immune response" "Cluster 2: Immune cells - Immune response" "Cluster 24: NB-4 - Immune response" "Cluster 63: NK-cells & T-cells - Immune response" Nucleoplasm "Plasma membrane, Cytosol" "HPA042970: AB_10796682" "unprognostic (3.01e-2)" "unprognostic (6.98e-3)" "unprognostic (3.96e-2)" "unprognostic (5.36e-3)" "unprognostic (1.23e-1)" "unprognostic (2.71e-2)" "unprognostic (6.52e-2)" "unprognostic (5.86e-2)" "unprognostic (4.88e-2)" "unprognostic (2.38e-2)" "prognostic favorable (1.04e-4)" "unprognostic (3.22e-2)" "prognostic unfavorable (9.45e-6)" "unprognostic (1.54e-1)" "unprognostic (3.91e-2)" "unprognostic (1.28e-1)" "unprognostic (2.69e-2)" 22.7 18.4 16.1 28.8 16.2 91.2 16.0 14.4 24.5 18.3 13.9 18.3 14.1 16.6 3.2 11.8 20.0 14.0 21.3 15.5 15.0 20.7 23.4 48.3 40.4 19.4 16.8 17.8 19.5 5.4 17.6 8.2 17.6 19.7 4.9 3.4 14.8 5.8 21.3 11.8 37.2 6.3 16.9 101.6 17.8 12.8 20.9 18.0 18.8 8.2 21.1 18.1 14.4 20.0 10.3 15.9 12.5 18.4 5.8 5.0 23.3 10.3 6.5 11.8 5.3 11.1 6.4 12.4 13.0 6.0 6.8 11.1 7.2 6.8 4.7 6.4 21.7 16.7 12.4 18.7 15.9 16.7 20.4 6.0 6.4 9.4 8.2 6.9 12.4 20.6 28.6 8.8 5.0 20.3 38.9 108.0 20.3 4.4 21.5 36.3 7.8 32.2 5.3 4.5 11.8 12.3 23.9 4.8 12.1 5.9 13.4 53.3 18.6 8.7 13.4 13.5 12.5 19.9 13.5 31.6 7.8 62.8 12.4 7.0 25.6 61.3 31.6 19.1 27.7 4.2 19.3 27.6 23.8 3.9 15.7 22.9 40.4 11.3 22.7 14.8 21.8 21.6 16.1 16.2 14.4 24.5 15.5 15.0 19.4 16.8 17.6 16.9 20.9 20.0 15.2 9.6 3.6 7.8 23.5 4.8 4.6 2.4 6.2 10.1 6.0 7.1 2.8 4.3 3.1 7.3 6.2 8.8 132.3 2.3 9.8 6.5 1.4 5.2 7.4 11.0 4.9 13.7 6.5 9.2 9.6 8.8 8.2 4.9 21.0 12.3 8.6 4.8 38.8 8.4 4.8 3.1 2.0 46.7 32.4 2.5 9.3 52.4 10.6 15.0 41.5 11.7 111.2 3.5 4.5 5.5 1.0 7.9 55.1 4.5 1.8 7.0 4.7 9.6 6.6 8.9 10.0 9.1 9.9 4.8 5.8 3.7 73.1 12.2 3.7 1.9 RNF167 DKFZP566H073 ENSG00000108523 "Ring finger protein 167" Q9H6Y7 17 4940008-4945222 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049810 Approved Approved "Vesicles,Mitotic spindle,Centriolar satellite,Cytosol" Yes NA "Cluster 5: Granulocytes - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 2: Karpas-707 - Immune response" "Cluster 63: NK-cells & T-cells - Immune response" "Vesicles, Cytosol" "Mitotic spindle, Centriolar satellite" "HPA049810: AB_2680894" "unprognostic (1.13e-1)" "unprognostic (5.12e-2)" "unprognostic (2.29e-3)" "unprognostic (1.63e-2)" "unprognostic (3.43e-2)" "unprognostic (7.32e-2)" "unprognostic (2.18e-1)" "unprognostic (6.77e-2)" "unprognostic (7.46e-2)" "unprognostic (2.07e-2)" "prognostic favorable (2.03e-6)" "unprognostic (2.16e-1)" "prognostic favorable (4.47e-4)" "unprognostic (7.62e-2)" "unprognostic (1.93e-1)" "unprognostic (3.26e-1)" "unprognostic (1.12e-1)" 75.0 110.6 141.9 53.0 146.7 69.0 73.1 146.4 179.9 93.2 138.6 111.5 66.6 94.9 76.4 122.1 84.3 45.3 131.8 141.5 146.4 106.7 184.2 77.5 64.5 146.3 145.4 87.4 115.1 105.8 96.8 50.7 146.3 95.0 65.7 98.1 92.5 70.5 152.9 127.8 100.5 52.8 142.4 113.8 111.8 110.6 150.3 98.1 93.4 94.2 71.6 106.7 90.4 153.3 102.6 143.1 61.1 73.7 132.8 68.7 92.7 63.4 76.1 119.7 93.4 96.2 43.3 71.5 120.3 93.5 63.9 147.5 103.2 114.8 86.1 74.5 166.1 121.9 164.4 94.9 100.6 59.0 245.0 79.6 176.5 129.8 116.2 74.6 77.2 101.0 49.9 237.5 96.2 66.3 92.8 70.6 75.4 102.0 86.8 62.8 61.9 91.5 137.3 77.4 49.2 61.1 56.0 92.9 81.9 83.1 87.3 55.9 49.5 76.6 48.3 66.8 119.3 79.5 88.0 23.7 98.4 80.6 77.9 108.4 88.8 236.9 195.3 94.0 153.4 100.4 148.0 195.7 73.9 98.7 103.2 152.2 219.8 118.8 117.7 75.9 153.0 177.0 141.9 146.7 146.4 179.9 141.5 146.4 146.3 145.4 146.3 142.4 150.3 153.3 36.9 0.0 3.9 12.4 54.3 68.6 44.4 65.8 51.8 43.2 56.6 44.7 15.8 77.2 38.9 49.7 20.9 120.1 64.7 65.2 56.7 78.5 59.6 29.8 25.1 36.4 31.8 60.6 11.3 66.7 139.7 36.3 36.2 32.2 14.0 26.3 45.7 95.1 58.4 18.5 11.2 45.7 65.1 41.3 43.6 86.5 48.7 36.1 39.2 6.5 53.1 46.9 114.4 10.1 17.9 60.7 44.9 53.8 59.1 32.6 108.2 64.0 31.1 32.3 39.5 28.4 35.1 127.1 106.7 61.4 83.3 125.2 82.5 37.2 59.6 48.0 RNF168 FLJ35794 ENSG00000163961 "Ring finger protein 168" Q8IYW5 3 196468783-196503768 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Chromatin regulator, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 199.9;Late spermatids: 459.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA046109 Enhanced "Nucleoplasm,Nuclear bodies" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoplasm, Nuclear bodies" "HPA046109: AB_2679540" "unprognostic (6.15e-3)" "prognostic favorable (8.21e-4)" "unprognostic (3.11e-1)" "unprognostic (1.11e-2)" "unprognostic (4.22e-1)" "unprognostic (5.04e-2)" "prognostic unfavorable (2.29e-4)" "unprognostic (6.81e-3)" "unprognostic (5.30e-2)" "unprognostic (1.63e-1)" "prognostic unfavorable (8.31e-4)" "unprognostic (4.83e-3)" "unprognostic (2.80e-3)" "unprognostic (5.98e-2)" "unprognostic (1.45e-1)" "unprognostic (1.95e-2)" "unprognostic (6.65e-2)" 8.6 4.8 3.9 6.0 4.2 20.6 6.8 5.9 4.3 9.3 4.4 6.1 6.1 6.0 4.0 7.9 5.9 4.5 6.8 3.2 6.3 4.7 10.4 8.1 7.2 6.1 5.2 7.4 4.8 4.0 3.5 5.4 6.5 5.3 5.7 4.9 5.8 4.1 13.1 11.5 5.6 5.3 4.9 6.8 5.8 10.7 6.0 7.7 4.9 8.3 8.7 6.7 9.3 6.0 21.6 8.5 14.8 19.5 13.6 9.8 21.1 12.9 8.1 8.5 13.3 16.6 10.4 22.7 29.1 10.8 11.9 21.3 21.0 15.4 13.0 10.9 10.3 43.0 22.2 20.7 7.0 13.3 10.3 9.8 5.8 13.3 11.7 6.0 12.6 18.4 13.1 23.1 8.7 36.4 44.6 7.8 17.6 11.6 10.8 19.7 17.2 18.4 7.2 29.2 12.3 12.4 14.6 17.7 11.1 10.9 26.8 11.7 12.4 14.6 11.4 15.7 17.2 19.6 19.7 33.2 14.3 15.8 11.9 30.0 7.3 8.8 12.2 8.0 10.9 6.3 10.1 8.8 6.6 6.6 8.8 9.4 8.0 8.7 12.2 6.2 7.0 7.5 3.9 4.2 5.9 4.3 3.2 6.3 6.1 5.2 6.5 4.9 6.0 6.0 34.4 16.0 37.5 16.0 37.7 100.1 49.8 30.8 52.3 36.0 17.3 15.0 21.7 12.8 20.0 14.7 60.5 14.6 76.4 25.3 17.6 14.0 199.9 17.0 20.8 33.3 14.4 14.1 33.5 8.9 26.6 27.9 23.9 24.0 50.1 24.0 24.3 25.9 17.9 15.2 36.0 18.5 28.5 32.4 98.8 459.7 20.2 33.9 26.6 28.1 38.2 12.7 42.2 25.1 27.4 10.5 17.3 20.7 37.9 27.7 11.4 10.3 17.1 39.8 13.1 23.6 25.7 13.8 54.9 55.5 126.6 10.7 63.7 20.3 22.4 50.3 RNF169 KIAA1991 ENSG00000166439 "Ring finger protein 169" Q8NCN4 11 74748849-74842413 "Enzymes, Predicted intracellular proteins" "DNA damage, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038505, HPA046138, HPA047952" Uncertain Enhanced "Nucleoplasm,Nucleoli,Nucleoli rim,Nuclear bodies,Cytosol" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Nuclear bodies" "Nucleoli, Nucleoli rim, Cytosol" "HPA038505: , HPA046138: AB_2679553, HPA047952: " "unprognostic (1.71e-1)" "unprognostic (4.18e-2)" "unprognostic (4.34e-2)" "unprognostic (3.72e-2)" "unprognostic (3.86e-2)" "unprognostic (3.25e-2)" "unprognostic (1.74e-1)" "unprognostic (1.35e-1)" "unprognostic (2.68e-1)" "unprognostic (6.47e-2)" "prognostic unfavorable (8.04e-4)" "unprognostic (2.76e-1)" "unprognostic (1.46e-1)" "unprognostic (3.23e-1)" "unprognostic (2.34e-1)" "unprognostic (9.55e-3)" "unprognostic (1.21e-1)" 4.2 2.8 3.8 6.7 6.2 14.4 5.6 6.2 4.4 5.5 5.4 4.4 4.0 7.6 4.2 10.1 5.6 4.8 3.2 4.0 4.4 4.6 5.0 5.9 6.3 5.4 5.0 7.6 4.4 5.6 2.1 4.7 5.4 5.2 5.3 6.1 4.5 4.3 6.8 5.5 4.4 7.6 4.4 7.3 4.6 2.9 4.6 7.7 5.8 5.8 6.7 5.2 5.4 9.2 10.2 7.7 9.1 9.0 5.8 7.7 3.7 7.9 7.4 8.6 7.4 13.0 7.5 18.2 7.9 9.5 5.8 9.6 12.4 9.3 11.2 9.1 8.0 12.6 15.3 5.1 6.6 6.8 10.1 7.1 7.2 9.8 22.1 9.6 14.0 12.2 11.4 14.1 8.7 8.6 11.6 12.0 3.6 12.9 5.0 10.7 21.7 9.9 5.5 10.6 4.1 7.4 10.6 8.0 16.6 7.3 9.9 8.6 9.4 14.2 11.8 9.0 7.1 10.2 5.8 21.1 2.8 7.3 8.4 1.2 0.5 0.4 0.4 0.3 0.3 0.0 0.4 0.2 0.2 0.1 0.3 0.2 1.4 0.3 0.3 0.2 0.3 0.2 3.8 6.2 6.2 4.4 4.0 4.4 5.4 5.0 5.4 4.4 4.6 9.2 18.8 9.6 11.4 51.6 18.4 19.9 30.6 7.1 20.5 58.2 12.6 9.8 3.0 17.2 8.3 3.7 52.1 5.5 24.6 9.8 5.9 10.2 2.8 30.5 26.7 17.2 12.0 18.3 40.8 11.1 6.4 16.0 14.8 30.1 7.0 24.4 10.8 12.3 8.5 37.0 43.2 8.7 2.0 15.6 19.9 3.1 7.5 16.6 10.6 25.3 12.6 22.9 26.8 42.7 68.7 10.1 6.8 10.5 18.5 49.7 6.3 12.1 8.9 33.7 26.3 31.9 18.7 9.4 11.7 16.4 18.6 8.1 22.2 14.0 10.4 42.2 RNF170 "ADSA, DKFZP564A022, SNAX1" ENSG00000120925 "Ring finger protein 170" Q96K19 8 42849637-42897290 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 89.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA050931, HPA054621" Uncertain NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 52: Non-specific - Transcription" "HPA050931: AB_2681279, HPA054621: AB_2682545" "unprognostic (3.06e-2)" "unprognostic (4.20e-1)" "unprognostic (9.54e-2)" "unprognostic (6.37e-2)" "unprognostic (4.59e-2)" "unprognostic (2.84e-2)" "unprognostic (1.04e-1)" "unprognostic (1.32e-1)" "unprognostic (3.23e-2)" "unprognostic (1.17e-1)" "unprognostic (2.59e-1)" "unprognostic (3.03e-2)" "unprognostic (1.61e-3)" "unprognostic (4.13e-3)" "unprognostic (2.00e-1)" "unprognostic (1.49e-1)" "unprognostic (2.13e-1)" 9.3 11.7 14.5 7.5 15.6 2.4 12.7 16.3 16.8 7.9 11.5 11.1 10.3 9.5 14.9 14.2 9.3 9.2 7.7 14.1 15.8 16.4 19.7 9.3 9.4 15.9 15.5 12.3 8.1 13.5 9.5 19.2 16.2 11.0 11.3 35.6 11.0 10.6 11.9 15.1 11.4 7.6 15.0 9.1 10.7 5.9 15.6 6.1 28.8 9.2 9.9 7.6 8.5 18.3 11.4 18.1 18.2 9.2 29.4 29.7 10.8 13.3 18.1 12.3 13.2 8.5 36.0 13.6 15.7 12.8 22.1 9.6 9.6 13.2 10.8 9.4 10.4 15.9 8.5 9.3 16.1 2.0 10.9 26.0 20.4 9.3 18.8 16.0 13.3 15.0 14.6 15.8 19.9 3.4 17.0 9.5 8.6 24.1 6.5 8.7 24.2 7.7 19.6 10.8 4.7 14.3 12.8 8.9 23.0 17.7 23.1 9.5 19.5 13.2 5.8 17.8 4.3 25.2 26.4 15.7 18.2 6.7 13.6 1.4 5.7 2.1 2.9 5.7 4.2 6.6 4.8 5.3 8.8 3.9 5.6 4.1 0.6 4.9 5.5 8.9 6.7 4.5 14.5 15.6 16.3 16.8 14.1 15.8 15.9 15.5 16.2 15.0 15.6 18.3 13.5 48.1 20.5 41.1 16.1 7.6 13.1 22.3 5.7 44.8 14.9 9.5 11.5 15.7 29.2 23.9 89.6 41.6 9.8 22.1 17.6 21.6 1.7 16.0 14.5 15.2 13.1 5.5 36.7 27.8 19.4 20.0 11.2 13.3 9.5 25.5 21.8 21.7 22.9 21.9 43.7 15.3 20.3 18.5 9.2 2.4 15.2 15.4 8.8 15.9 21.9 31.8 30.9 36.2 75.9 32.2 18.4 20.7 10.7 9.6 34.5 22.1 33.3 72.1 13.1 23.9 12.1 14.9 19.3 12.5 11.5 31.2 12.8 25.7 16.6 12.2 RNF180 ENSG00000164197 "Ring finger protein 180" Q86T96 5 64165843-64372869 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "parathyroid gland: 25.3" "Cell type enhanced" "Detected in many" "Excitatory neurons: 90.5;Inhibitory neurons: 151.6;Oligodendrocyte precursor cells: 162.3" "Cancer enhanced" "Detected in many" "glioma: 7.6" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enriched" "Detected in some" 6 "RPMI-8226: 29.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA006897 Approved Approved Cytosol NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 25: RPMI-8226 - Immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Cytosol "HPA006897: AB_1856348" "unprognostic (7.46e-2)" "unprognostic (3.90e-3)" "unprognostic (3.19e-2)" "unprognostic (8.62e-2)" "unprognostic (2.45e-1)" "unprognostic (2.72e-1)" "unprognostic (5.57e-2)" "unprognostic (2.38e-2)" "unprognostic (1.08e-1)" "unprognostic (1.69e-1)" "unprognostic (3.37e-3)" "unprognostic (3.68e-2)" "prognostic favorable (6.81e-5)" "unprognostic (2.01e-2)" "unprognostic (3.35e-2)" "unprognostic (1.81e-2)" "unprognostic (9.81e-3)" 5.4 5.1 3.2 1.5 3.9 0.3 3.6 2.6 5.1 4.1 2.9 3.3 1.7 7.7 7.7 4.2 4.9 4.2 7.0 2.8 8.2 8.1 4.5 3.7 1.3 3.9 5.8 7.6 4.2 25.3 3.5 0.6 4.7 7.3 1.3 6.0 4.6 10.6 2.7 4.1 1.4 5.7 4.4 3.0 2.6 3.4 6.6 0.7 14.0 4.1 0.9 3.3 2.3 4.5 0.0 0.1 1.4 0.0 0.0 0.0 0.3 1.2 0.5 1.2 0.7 0.0 0.1 0.0 0.1 0.9 0.7 0.2 0.0 0.5 0.2 0.0 0.1 0.4 0.0 0.0 0.5 0.0 0.3 0.1 3.0 0.0 0.1 4.8 0.0 0.0 0.0 0.0 2.5 0.4 0.0 0.0 0.6 0.0 1.4 0.1 3.7 29.4 2.1 0.3 0.3 0.1 0.0 0.3 0.0 1.8 1.5 0.1 0.1 0.0 3.5 0.1 3.3 0.0 0.0 0.0 0.6 0.0 3.9 1.2 0.6 1.7 0.6 0.2 0.9 0.5 1.0 1.1 0.2 0.8 1.4 1.3 1.0 0.8 0.3 0.4 0.7 0.0 3.2 3.9 2.6 5.1 2.8 8.2 3.9 5.8 4.7 4.4 6.6 4.5 9.5 16.0 12.3 51.6 0.5 4.6 8.9 1.3 7.4 16.6 8.1 4.2 10.9 10.0 4.9 16.5 14.6 0.0 0.0 0.0 7.9 5.8 12.5 14.2 6.1 6.3 1.2 0.0 90.5 2.6 0.1 7.9 6.1 32.9 0.0 5.7 14.3 5.9 0.1 11.8 151.6 1.9 0.0 0.6 1.1 8.8 34.5 0.5 5.4 32.8 0.0 30.1 0.0 162.3 50.1 3.1 2.7 25.2 0.0 6.4 1.2 15.9 1.9 16.9 39.5 24.2 20.4 18.9 12.0 2.9 7.4 0.0 0.3 4.1 1.6 4.5 RNF181 HSPC238 ENSG00000168894 "Ring finger protein 181" Q9P0P0 2 85595725-85597708 "Enzymes, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Proximal tubular cells: 851.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA046112, HPA062121" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 29: Non-specific - Vesicular transport" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm Cytosol "HPA046112: AB_2679542, HPA062121: AB_2684687" "unprognostic (3.79e-1)" "unprognostic (8.31e-2)" "unprognostic (5.08e-2)" "unprognostic (2.05e-1)" "unprognostic (3.24e-1)" "unprognostic (1.67e-2)" "unprognostic (3.12e-1)" "unprognostic (2.22e-2)" "unprognostic (3.22e-2)" "unprognostic (5.85e-2)" "unprognostic (1.11e-1)" "unprognostic (4.96e-2)" "prognostic unfavorable (1.06e-6)" "unprognostic (3.24e-1)" "unprognostic (2.04e-1)" "prognostic favorable (4.59e-5)" "unprognostic (1.49e-2)" 110.4 135.0 87.6 60.2 92.4 76.7 109.8 93.3 101.9 105.5 85.7 101.3 75.1 85.2 85.0 118.0 87.4 50.2 141.1 88.9 93.2 174.3 169.5 114.0 69.1 92.8 91.5 90.7 168.5 80.1 61.9 82.9 91.8 111.0 69.0 36.0 110.0 73.0 172.1 102.6 91.4 65.2 93.7 101.2 121.8 107.6 94.5 59.5 93.8 105.1 89.6 107.5 98.7 97.7 125.7 120.4 96.3 103.8 94.3 113.4 152.2 104.7 195.4 207.7 199.7 185.2 132.2 118.8 196.8 150.6 206.2 117.5 83.5 164.8 223.8 133.9 104.0 91.6 58.5 224.7 168.0 104.8 122.1 122.0 208.5 144.5 237.1 166.2 175.4 110.8 109.1 119.7 282.7 193.0 97.8 235.6 68.6 164.9 180.2 105.1 202.5 171.7 200.8 109.3 57.2 74.5 88.4 126.2 171.7 114.8 125.4 136.2 160.1 104.9 77.2 218.4 149.6 170.3 143.5 143.1 166.4 144.9 95.5 213.9 418.5 339.7 176.1 326.0 164.6 251.9 181.4 169.2 321.4 214.8 156.4 153.0 356.6 195.5 254.9 360.4 262.0 439.0 87.6 92.4 93.3 101.9 88.9 93.2 92.8 91.5 91.8 93.7 94.5 97.7 89.3 147.4 104.8 7.8 89.3 116.9 102.5 343.7 75.7 27.1 92.8 95.4 122.8 124.4 200.2 150.8 2.1 237.1 104.2 148.1 416.7 236.5 365.7 70.5 63.6 102.8 70.2 85.2 2.2 290.4 260.2 113.7 55.0 93.2 102.7 59.0 99.6 214.4 263.4 18.5 2.2 138.4 185.1 154.0 182.3 250.6 88.3 147.6 170.7 3.7 188.7 80.4 94.7 2.0 6.9 304.0 201.5 78.2 113.8 123.8 271.9 851.7 141.7 29.1 59.2 66.3 108.8 121.3 33.1 97.9 118.6 221.2 86.7 62.6 102.0 115.6 RNF182 MGC33993 ENSG00000180537 "Ring finger protein 182" Q8N6D2 6 13924446-13980310 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 24.7;choroid plexus: 12.7" "Cell type enriched" "Detected in some" 4 "Astrocytes: 85.2" "Cancer enhanced" "Detected in many" "glioma: 5.5" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HeLa: 81.3;RPTEC TERT1: 67.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA012309 Approved Approved "Nucleoplasm,Golgi apparatus,Vesicles" NA NA "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 20: HeLa - Mitochondria" "Cluster 64: Astrocytes - Nervous system maintenance" "Nucleoplasm, Golgi apparatus" Vesicles "HPA012309: AB_1856349" "unprognostic (1.29e-1)" "unprognostic (1.06e-2)" "unprognostic (2.74e-1)" "prognostic unfavorable (4.66e-5)" "unprognostic (6.16e-2)" "unprognostic (2.08e-1)" "unprognostic (9.01e-2)" "unprognostic (6.12e-2)" "unprognostic (1.71e-2)" "unprognostic (4.21e-1)" "unprognostic (6.04e-2)" "unprognostic (1.42e-1)" "unprognostic (1.05e-1)" "unprognostic (9.33e-5)" "unprognostic (6.66e-3)" "unprognostic (1.33e-3)" "unprognostic (1.26e-1)" 1.1 0.1 12.2 0.1 13.3 8.4 0.6 22.5 17.7 0.8 12.7 0.2 0.2 0.6 1.1 0.3 1.2 0.2 0.3 17.6 12.2 1.1 0.0 3.3 0.2 16.9 17.7 0.3 1.7 5.8 1.8 1.3 16.5 0.4 0.1 8.8 1.3 2.1 0.2 0.4 0.3 0.3 14.2 0.2 0.2 3.7 24.7 1.5 1.3 0.1 0.0 0.3 0.4 12.2 0.2 6.5 12.0 0.0 4.1 5.0 0.7 6.3 8.6 17.0 16.4 0.3 0.1 0.0 0.1 6.8 18.5 0.0 14.3 0.1 30.9 0.0 4.7 0.4 81.3 0.0 0.0 0.1 0.0 2.8 0.0 26.3 0.2 19.5 0.3 3.5 0.5 0.0 11.9 0.2 0.1 2.2 6.9 0.1 23.9 3.8 2.9 1.0 67.3 0.0 14.2 13.7 0.6 0.0 24.8 4.4 0.0 2.4 6.5 20.7 4.4 0.2 14.3 0.0 0.0 0.0 14.1 0.0 30.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.2 13.3 22.5 17.7 17.6 12.2 16.9 17.7 16.5 14.2 24.7 12.2 0.2 0.0 0.0 85.2 0.1 0.3 0.1 0.0 0.0 19.3 0.2 0.0 0.8 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.9 1.6 0.4 0.1 0.2 0.0 9.7 8.6 0.0 0.1 0.4 0.0 0.1 0.0 5.4 0.0 0.1 0.1 15.2 1.5 0.1 0.0 0.0 0.3 1.4 0.3 0.0 0.0 5.6 0.0 14.7 0.0 2.5 0.4 0.1 0.0 0.0 0.0 0.1 0.0 1.1 0.1 1.3 6.6 0.0 1.3 5.7 3.2 0.0 0.0 0.3 0.3 0.0 0.1 0.1 RNF183 MGC4734 ENSG00000165188 "Ring finger protein 183" Q96D59 9 113297093-113303376 "Enzymes, Predicted membrane proteins" "Apoptosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "epididymis: 16.4;kidney: 11.5" "Cell type enhanced" "Detected in some" "Basal respiratory cells: 15.9;Club cells: 9.8;Endometrial ciliated cells: 13.4;Glandular and luminal cells: 20.5;Ionocytes: 22.4;Proximal tubular cells: 26.4;Respiratory ciliated cells: 13.0" "Cancer enhanced" "Detected in many" "endometrial cancer: 7.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 8 "SCLC-21H: 18.8" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA057675 Uncertain NA NA "Cluster 68: Epididymis - Unknown function" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 44: Endometrium - Transcription" "HPA057675: AB_2683499" "unprognostic (1.23e-2)" "unprognostic (3.17e-1)" "unprognostic (1.11e-1)" "prognostic favorable (7.95e-6)" "unprognostic (2.56e-1)" "unprognostic (1.75e-2)" "unprognostic (1.54e-3)" "unprognostic (1.27e-2)" "unprognostic (1.03e-1)" "unprognostic (7.65e-2)" "unprognostic (3.27e-1)" "unprognostic (1.98e-1)" "prognostic favorable (3.51e-4)" "unprognostic (5.50e-2)" "unprognostic (8.84e-2)" "unprognostic (9.61e-2)" "unprognostic (2.53e-3)" 0.1 0.1 0.3 0.4 0.2 0.0 1.0 0.2 0.4 1.5 0.2 0.5 0.4 1.2 16.4 4.9 1.3 5.7 0.1 0.2 0.1 11.5 0.2 0.3 0.0 0.2 0.2 0.3 0.3 0.1 2.0 0.0 0.2 1.0 0.4 1.2 6.8 0.3 0.0 0.4 0.3 0.0 0.3 0.1 3.4 5.0 0.4 0.0 0.4 0.0 0.1 0.3 0.5 0.3 0.0 0.1 0.0 0.0 0.0 0.1 2.3 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 18.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.2 0.2 0.4 0.2 0.1 0.2 0.2 0.2 0.3 0.4 0.3 0.3 0.0 0.0 0.3 0.5 0.0 0.4 15.9 0.0 0.6 3.8 2.9 0.4 5.7 9.8 5.5 0.0 0.0 0.2 0.9 1.9 0.2 0.2 13.4 1.1 0.5 8.4 0.0 0.0 0.9 0.1 0.2 4.6 20.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.5 22.4 0.0 0.0 0.1 0.3 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.2 2.2 0.7 0.4 0.0 0.5 0.2 26.4 13.0 3.3 0.0 0.4 0.6 3.3 0.7 1.4 0.0 0.0 0.3 0.1 1.5 1.0 RNF185 FLJ38628 ENSG00000138942 "Ring finger protein 185" Q96GF1 22 31160182-31207019 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Autophagy, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 1: Thyroid gland - Transcription" "Cluster 30: Epithelial cell lines - Translation" "Cluster 4: Macrophages - Innate immune response" "unprognostic (1.50e-1)" "unprognostic (1.04e-1)" "unprognostic (7.11e-2)" "unprognostic (2.33e-1)" "unprognostic (3.65e-3)" "unprognostic (4.76e-3)" "unprognostic (2.60e-3)" "unprognostic (1.12e-2)" "unprognostic (3.97e-1)" "unprognostic (2.56e-1)" "unprognostic (2.61e-1)" "unprognostic (9.41e-2)" "prognostic favorable (4.82e-5)" "unprognostic (3.04e-1)" "unprognostic (1.63e-1)" "unprognostic (2.86e-1)" "unprognostic (1.10e-1)" 19.8 18.7 21.5 14.4 22.5 10.1 22.8 21.7 25.1 22.3 22.5 23.4 20.5 22.5 25.1 25.9 23.0 16.4 21.1 22.5 22.1 36.2 48.4 19.0 16.2 21.7 22.0 26.1 19.2 48.8 15.8 21.0 22.0 38.2 22.2 16.5 30.2 28.7 23.4 29.9 21.9 25.6 21.9 16.6 21.7 10.8 23.2 21.0 52.0 25.5 21.3 24.2 23.0 23.6 23.7 13.8 26.1 29.9 51.8 34.5 24.9 27.7 53.3 37.2 50.2 15.6 11.1 22.5 15.2 49.3 32.8 14.6 25.3 28.6 38.1 22.6 27.5 9.8 13.2 19.1 72.5 24.1 14.6 37.1 100.8 26.2 60.2 34.0 31.7 23.5 11.7 26.2 45.2 16.8 20.8 13.5 11.7 48.8 15.2 21.1 26.1 26.5 27.0 20.4 11.6 23.4 20.2 26.5 41.0 26.7 18.4 15.8 22.2 26.1 18.7 30.9 13.6 36.2 31.6 28.4 34.5 15.1 21.4 16.9 15.7 9.0 12.2 15.8 13.6 10.0 12.4 13.8 13.3 8.2 12.5 11.5 22.3 16.9 13.7 4.9 14.6 14.8 21.5 22.5 21.7 25.1 22.5 22.1 21.7 22.0 22.0 21.9 23.2 23.6 9.3 22.4 12.6 10.7 8.8 9.1 10.3 10.0 9.6 11.0 14.2 10.8 5.5 20.0 11.5 18.4 8.4 13.0 11.3 16.4 21.5 15.1 19.0 8.9 8.2 8.5 16.8 5.0 14.0 14.9 23.2 10.9 8.2 10.3 5.7 8.4 23.2 28.9 14.2 8.4 17.3 15.8 14.2 8.8 7.5 18.3 7.5 10.5 8.8 10.3 10.7 11.9 7.2 13.6 22.5 15.5 12.7 15.8 6.8 14.5 17.7 22.9 12.4 7.8 6.6 9.5 9.3 7.4 9.8 10.6 10.7 37.2 7.2 6.0 7.8 9.8 RNF186 FLJ20225 ENSG00000178828 "Ring finger protein 186" Q9NXI6 1 19814029-19815283 "Enzymes, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "epididymis: 67.2;intestine: 131.1;pancreas: 43.4" "Group enriched" "Detected in some" 5 "Distal enterocytes: 41.6;Enteroendocrine cells: 86.6;Intestinal goblet cells: 46.6;Paneth cells: 123.4;Proximal tubular cells: 142.7;Undifferentiated cells: 110.3" "Group enriched" "Detected in many" 4 "colorectal cancer: 18.5;renal cancer: 12.1;stomach cancer: 7.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 5 "RPMI-8226: 1.8" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA034547, HPA035558" Enhanced NA NA "Cluster 56: Intestine - Transmembrane transport" "Cluster 25: RPMI-8226 - Immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA034547: AB_10670975, HPA035558: AB_2674678" "unprognostic (1.66e-2)" "unprognostic (2.49e-2)" "unprognostic (3.89e-1)" "unprognostic (5.93e-3)" "unprognostic (1.77e-3)" "unprognostic (3.23e-1)" "unprognostic (3.05e-1)" "unprognostic (3.25e-2)" "unprognostic (1.06e-1)" "unprognostic (3.76e-1)" "unprognostic (1.40e-1)" "unprognostic (8.60e-3)" 0.3 0.0 0.0 5.0 0.0 0.0 0.8 0.0 0.0 0.3 0.0 18.7 131.1 0.1 67.2 0.0 0.0 0.4 0.0 0.0 0.0 26.1 0.8 0.0 0.0 0.0 0.0 0.2 43.4 0.0 0.0 0.0 0.0 0.3 15.4 0.0 0.3 0.4 0.0 0.0 44.8 0.7 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.3 0.0 0.0 0.1 1.8 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 5.0 3.2 0.1 0.0 0.0 0.0 0.0 0.0 0.1 41.6 5.9 9.6 0.0 0.8 0.1 0.1 86.6 0.0 0.0 18.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 46.6 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.8 123.4 0.0 0.0 0.1 16.1 142.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 110.3 0.2 RNF187 "RACO-1, RACO1" ENSG00000168159 "Ring finger protein 187" Q5TA31 1 228487382-228496188 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Theca cells: 217.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "eosinophil: 3.6" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "U-266/70: 189.0" "Low region specificity" "Detected in all" HPA030098 Approved Supported Nucleoplasm,Cytosol Yes No "Cluster 52: Eosinophils - Transcription" "Cluster 18: Non-specific - Mitochondria" "Cluster 29: U-266 - Adaptive immune response" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Cytosol" "HPA030098: AB_10602923" "unprognostic (4.84e-2)" "unprognostic (1.97e-1)" "prognostic unfavorable (2.83e-4)" "unprognostic (4.90e-3)" "unprognostic (1.13e-1)" "unprognostic (2.93e-2)" "unprognostic (3.46e-2)" "unprognostic (2.53e-1)" "unprognostic (1.36e-1)" "unprognostic (5.66e-3)" "unprognostic (1.37e-1)" "unprognostic (1.55e-1)" "unprognostic (2.92e-3)" "unprognostic (1.59e-1)" "unprognostic (9.76e-2)" "unprognostic (1.76e-1)" "unprognostic (2.32e-2)" 26.8 66.6 16.2 7.5 16.2 11.3 25.8 14.8 24.3 40.5 3.4 28.1 8.6 31.8 4.3 59.1 28.7 5.6 35.4 15.9 16.9 40.7 52.0 23.6 7.3 19.4 15.2 39.3 34.5 22.5 47.7 5.5 18.4 33.5 3.7 9.0 39.7 8.2 64.2 45.0 22.5 5.6 15.6 37.0 27.6 20.8 18.5 8.5 36.1 19.8 6.1 29.9 41.2 19.8 26.7 23.1 14.8 28.9 16.8 12.5 26.6 21.5 17.3 15.6 12.7 12.8 19.2 65.9 43.1 28.9 11.4 20.9 19.1 22.1 5.8 25.9 28.5 20.8 13.2 12.6 46.1 22.1 34.4 20.4 44.7 11.6 15.8 18.3 14.0 52.6 35.6 115.2 12.4 17.7 35.2 20.8 30.7 19.1 24.0 27.8 12.5 61.5 11.4 17.2 29.9 30.0 21.9 44.1 62.3 4.3 34.6 50.2 27.8 18.3 16.9 19.6 19.3 189.0 56.7 36.4 46.7 22.7 28.7 0.0 0.5 3.6 0.6 1.0 0.7 0.5 0.7 1.0 0.6 1.0 0.6 0.7 0.1 0.4 1.4 0.7 0.6 0.3 16.2 16.2 14.8 24.3 15.9 16.9 19.4 15.2 18.4 15.6 18.5 19.8 54.0 25.6 15.5 8.1 47.2 36.2 42.9 10.6 38.7 85.2 59.5 58.5 70.8 65.8 14.2 40.5 18.8 19.7 52.2 39.8 113.5 15.2 0.8 35.5 47.2 32.1 40.0 118.4 16.6 24.5 27.1 54.4 34.7 32.0 44.5 45.0 41.7 67.4 27.4 55.5 17.2 36.6 2.0 40.1 30.5 4.2 24.5 35.8 39.2 12.2 29.7 145.3 62.8 7.1 12.6 21.4 23.4 25.9 35.4 44.0 32.9 126.4 10.3 47.7 19.7 52.2 38.4 4.2 21.5 57.0 55.3 17.6 54.6 217.5 38.6 31.7 RNF19A "DKFZp566B1346, dorfin, RNF19" ENSG00000034677 "Ring finger protein 19A, RBR E3 ubiquitin protein ligase" Q9NV58 8 100257060-100336218 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Karpas-707: 178.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB011455, HPA023652" Approved NA NA "Cluster 42: Non-specific - Transcription" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 2: Karpas-707 - Immune response" "Cluster 24: Non-specific - Transcription regulation" "CAB011455: AB_2180446, HPA023652: AB_1847836" "unprognostic (2.55e-1)" "unprognostic (1.13e-1)" "unprognostic (1.84e-1)" "unprognostic (7.09e-2)" "unprognostic (3.36e-1)" "unprognostic (2.12e-2)" "unprognostic (7.96e-2)" "unprognostic (8.92e-2)" "unprognostic (1.13e-1)" "unprognostic (5.97e-2)" "unprognostic (5.20e-2)" "unprognostic (2.99e-1)" "prognostic unfavorable (7.99e-5)" "unprognostic (8.44e-2)" "unprognostic (8.19e-2)" "unprognostic (2.02e-1)" "prognostic favorable (3.28e-5)" 32.0 18.8 29.1 32.7 28.7 57.4 28.6 22.7 25.5 52.0 17.6 25.9 24.0 41.3 16.4 21.6 30.5 43.1 25.0 25.3 48.3 30.0 49.3 34.7 55.4 40.2 36.0 27.4 25.9 16.1 15.2 26.9 33.0 22.0 26.5 27.2 22.3 18.7 28.0 31.8 37.9 32.6 37.3 31.5 27.4 53.0 36.1 34.3 18.8 31.0 43.8 35.9 27.3 40.7 26.7 16.9 14.8 16.9 27.7 23.1 18.7 23.4 22.5 22.0 19.9 9.0 17.3 15.7 41.6 24.7 10.2 18.9 11.6 17.4 29.6 65.3 9.4 26.1 86.8 13.5 22.8 5.3 15.6 23.3 26.1 17.5 33.1 26.9 34.3 17.3 14.8 178.6 21.8 13.5 24.6 9.0 5.4 18.2 15.5 9.8 10.0 30.7 60.2 41.7 11.4 24.6 24.5 14.9 23.3 30.6 13.1 20.5 33.9 25.3 19.9 18.7 14.3 85.5 59.3 10.4 16.2 17.4 15.4 26.3 8.6 8.1 16.3 6.8 10.4 15.5 13.4 12.6 5.7 13.9 6.9 9.8 19.6 6.2 14.2 14.1 14.7 5.8 29.1 28.7 22.7 25.5 25.3 48.3 40.2 36.0 33.0 37.3 36.1 40.7 70.8 51.3 51.6 106.7 101.7 40.1 83.4 56.9 18.8 29.9 44.7 32.5 40.6 110.1 83.6 44.1 60.5 11.0 184.8 61.6 7.9 65.0 183.8 165.9 78.2 66.3 20.8 124.8 76.9 40.2 14.5 62.5 67.8 242.1 43.0 172.0 32.2 42.9 23.0 58.9 69.7 25.9 42.7 30.5 41.8 259.4 58.4 39.2 21.4 73.1 24.1 43.5 65.9 35.7 39.9 49.0 32.0 68.8 161.7 66.3 50.9 54.1 106.2 48.4 19.7 77.4 46.3 77.8 47.2 26.1 60.4 8.2 204.6 46.3 21.8 144.9 RNF19B "FLJ90005, IBRDC3" ENSG00000116514 "Ring finger protein 19B" Q6ZMZ0 1 32936445-32964809 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Adaptive immunity, Immunity, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 79.0" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 16.9" "Lineage enriched" "Detected in all" 8 "granulocytes: 16.9" "Cell line enhanced" "Detected in all" "Daudi: 107.6;Karpas-707: 124.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA049587, HPA063640" Approved Approved Cytosol NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 2: Karpas-707 - Immune response" "Cluster 41: Macrophages - Immune response" Cytosol "HPA049587: AB_2680826, HPA063640: " "unprognostic (2.83e-2)" "unprognostic (1.77e-2)" "unprognostic (1.86e-2)" "unprognostic (2.01e-1)" "unprognostic (1.78e-2)" "prognostic favorable (3.39e-4)" "prognostic unfavorable (5.41e-6)" "unprognostic (8.78e-2)" "unprognostic (5.02e-1)" "unprognostic (1.69e-1)" "unprognostic (9.85e-2)" "unprognostic (1.38e-1)" "prognostic favorable (4.39e-5)" "unprognostic (2.58e-2)" "unprognostic (4.93e-2)" "unprognostic (3.30e-1)" "unprognostic (1.23e-2)" 14.5 19.1 10.7 24.3 9.6 74.1 10.9 14.5 10.7 16.8 7.6 23.3 25.0 15.0 5.0 35.3 12.3 17.4 10.4 9.9 12.1 21.1 11.3 21.1 17.7 10.7 9.6 9.7 9.2 11.5 7.9 14.9 11.8 11.0 25.8 18.9 15.4 8.9 16.2 22.6 21.7 18.0 11.6 15.1 13.1 79.0 10.8 13.0 9.0 11.1 30.6 30.1 20.9 11.6 18.7 14.3 11.9 11.3 7.1 9.6 79.5 8.5 10.0 14.7 15.6 16.8 54.9 107.6 14.2 10.7 18.2 26.5 14.3 19.8 13.3 39.6 9.5 9.2 10.5 16.9 22.5 14.7 19.0 7.9 36.3 32.5 39.3 17.2 31.9 10.3 11.7 124.8 14.5 6.1 9.6 18.4 19.2 21.1 15.8 12.7 17.3 11.3 11.5 26.4 18.9 9.6 27.0 9.1 63.1 29.1 8.0 20.8 35.1 8.1 11.5 21.1 15.1 29.6 16.1 38.0 11.9 14.7 12.5 6.1 2.0 4.0 1.6 1.9 1.3 1.2 1.4 0.7 1.4 1.5 0.4 0.6 16.9 1.0 1.7 0.6 1.7 0.8 10.7 9.6 14.5 10.7 9.9 12.1 10.7 9.6 11.8 11.6 10.8 11.6 20.6 12.8 4.4 5.5 8.7 46.1 27.0 26.7 24.5 4.6 15.8 11.7 16.2 10.0 9.9 7.3 2.1 12.6 14.6 48.0 1.9 12.9 34.8 25.4 7.3 15.3 11.3 5.2 9.7 11.5 6.3 8.4 13.3 36.9 4.5 3.2 7.1 4.8 13.5 3.3 9.8 22.1 6.1 20.9 37.7 26.3 2.1 42.4 5.4 19.7 39.5 2.8 2.1 7.5 6.6 25.7 31.9 3.8 4.6 34.2 38.6 9.2 14.4 7.7 0.0 5.9 9.6 34.7 16.3 23.9 32.5 7.4 10.3 2.3 16.3 41.7 RNF2 "BAP-1, BAP1, DING, HIPI3, RING1B, RING2" ENSG00000121481 "Ring finger protein 2" Q99496 1 185045526-185102603 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" "Repressor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Spermatogonia: 83.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA026803 Uncertain Enhanced "Nucleoplasm,Nuclear bodies" NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 28: Placenta - Pregnancy" "Cluster 5: NTERA-2 - Transcription" "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" Nucleoplasm "Nuclear bodies" "HPA026803: AB_10602086" "unprognostic (1.23e-1)" "unprognostic (3.71e-2)" "unprognostic (1.70e-1)" "unprognostic (1.35e-3)" "unprognostic (1.70e-2)" "unprognostic (1.19e-1)" "prognostic unfavorable (1.08e-5)" "unprognostic (5.85e-2)" "unprognostic (3.56e-3)" "unprognostic (1.62e-2)" "unprognostic (2.01e-2)" "unprognostic (5.51e-2)" "prognostic unfavorable (1.94e-7)" "unprognostic (2.08e-1)" "unprognostic (5.51e-2)" "unprognostic (9.89e-3)" "unprognostic (2.52e-1)" 9.5 8.1 5.4 10.2 6.7 13.8 12.5 6.1 7.0 10.3 3.7 9.3 8.4 10.7 8.5 8.4 8.6 9.4 7.4 7.0 7.5 9.6 8.3 8.3 11.5 4.0 4.8 9.3 9.6 8.7 5.6 21.7 4.8 8.5 9.7 11.8 9.6 10.4 8.2 6.4 6.5 10.9 4.5 10.4 9.6 21.9 7.9 12.3 10.8 9.0 12.3 16.5 8.7 5.1 34.0 18.6 62.8 25.4 17.8 30.3 65.3 24.0 28.4 35.5 28.3 29.9 53.3 10.2 29.2 29.0 24.4 11.5 43.7 32.7 41.7 31.1 28.4 54.9 10.2 25.8 27.5 56.1 29.7 29.7 19.6 29.6 36.4 27.9 36.6 34.4 44.7 22.5 25.1 21.2 48.5 17.6 86.3 27.4 11.0 55.1 41.3 9.8 25.7 23.6 18.9 33.4 17.3 9.9 46.7 67.8 19.7 27.5 28.4 25.4 33.6 25.1 29.8 39.0 26.2 36.3 16.1 25.7 28.9 31.0 22.4 27.7 17.1 27.7 24.4 20.1 15.5 15.8 25.7 21.9 15.1 15.6 9.8 24.4 29.9 13.4 17.8 16.3 5.4 6.7 6.1 7.0 7.0 7.5 4.0 4.8 4.8 4.5 7.9 5.1 22.6 3.2 6.4 11.4 23.6 23.2 27.6 10.2 26.7 10.3 18.2 11.8 8.4 7.2 6.6 9.2 4.2 25.4 24.5 11.2 23.5 11.5 6.1 11.2 10.8 20.3 29.5 29.4 23.1 12.6 53.0 17.9 12.8 10.3 12.7 16.9 23.2 8.8 20.1 6.7 20.5 9.2 8.2 21.4 55.2 5.6 9.6 22.0 21.4 20.6 25.4 13.3 10.3 18.6 15.1 11.3 16.9 11.7 15.5 30.2 4.1 16.4 8.8 7.2 0.0 11.7 13.4 35.6 83.1 15.8 20.3 28.5 20.7 15.6 11.3 38.0 RNF20 "BRE1, BRE1A, FLJ11189, FLJ20382, hBRE1, KAIA2779" ENSG00000155827 "Ring finger protein 20" Q5VTR2 9 101533853-101563344 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Chromatin regulator, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 76.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB012478, HPA051773" Supported Enhanced Nucleoplasm NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 21: Non-specific - Transcription" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm "CAB012478: , HPA051773: AB_2681604" "unprognostic (7.02e-2)" "unprognostic (2.21e-1)" "unprognostic (9.04e-2)" "unprognostic (2.03e-1)" "unprognostic (3.12e-2)" "unprognostic (1.68e-1)" "unprognostic (1.41e-2)" "unprognostic (2.90e-1)" "unprognostic (2.01e-1)" "unprognostic (5.47e-2)" "unprognostic (7.27e-3)" "unprognostic (1.60e-1)" "prognostic favorable (1.64e-6)" "unprognostic (2.72e-1)" "unprognostic (1.76e-1)" "unprognostic (2.32e-1)" "unprognostic (9.54e-3)" 17.8 17.8 21.3 16.3 24.6 14.8 19.0 22.0 22.8 17.0 21.4 17.7 11.1 19.0 19.2 21.6 19.8 14.1 26.4 20.4 23.2 21.4 15.7 16.3 18.6 22.8 23.7 21.5 21.3 28.1 10.3 14.6 23.7 20.9 16.9 30.4 16.7 17.9 29.7 17.3 12.3 18.9 22.0 17.6 14.5 32.5 22.6 19.9 23.4 24.9 21.0 15.0 15.0 26.8 25.8 64.2 36.4 40.0 43.8 34.4 31.0 44.1 35.3 43.1 37.6 39.2 26.8 56.8 23.2 34.3 36.0 64.0 42.6 37.5 44.1 59.7 19.8 30.5 55.9 39.7 32.2 53.0 35.2 34.0 39.4 38.2 49.2 32.4 25.7 20.7 29.5 32.5 47.4 33.6 41.4 14.0 80.5 57.8 32.3 39.4 125.7 28.3 17.8 24.5 38.7 48.6 62.1 32.9 36.1 36.3 29.7 24.7 36.6 39.8 39.7 28.6 37.3 35.1 118.0 30.4 35.1 19.6 49.2 24.5 15.2 23.7 20.4 20.3 15.5 15.3 16.7 15.4 14.6 12.4 17.3 16.4 15.7 17.1 30.0 9.2 14.7 13.4 21.3 24.6 22.0 22.8 20.4 23.2 22.8 23.7 23.7 22.0 22.6 26.8 15.9 25.6 31.2 10.7 16.8 6.4 9.7 13.7 17.1 32.4 11.6 11.4 49.5 8.6 23.9 22.0 6.2 16.7 10.2 17.9 5.9 18.3 54.5 20.3 18.5 18.7 24.6 22.3 16.3 13.8 11.5 16.9 10.2 11.5 22.1 19.7 11.7 18.1 16.4 43.7 18.7 12.1 16.2 27.4 4.3 21.4 18.0 20.0 10.6 8.4 31.4 31.4 33.0 11.1 21.9 11.0 13.0 23.7 13.1 9.3 10.1 11.5 28.5 26.5 32.9 21.8 17.5 76.0 16.7 18.3 5.8 7.7 16.1 15.4 15.3 6.4 RNF213 "ALO17, C17orf27, KIAA1554, KIAA1618, MYMY2, NET57" ENSG00000173821 "Ring finger protein 213" Q63HN8 17 80260866-80398786 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Angiogenesis, Ubl conjugation pathway" "Hydrolase, Transferase" "Cancer-related genes, Disease variant, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "NK-cells: 396.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HDLM-2: 90.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003347, HPA026790" Approved Supported Cytosol NA NA 3500 "Cluster 33: Neutrophils - Chromatin organization" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 63: NK-cells & T-cells - Immune response" Cytosol "HPA003347: AB_1079204, HPA026790: AB_10602296" "unprognostic (8.98e-2)" "unprognostic (1.60e-1)" "unprognostic (8.97e-3)" "prognostic unfavorable (4.65e-5)" "unprognostic (7.39e-2)" "unprognostic (3.99e-2)" "unprognostic (2.23e-2)" "unprognostic (1.52e-1)" "unprognostic (4.57e-2)" "unprognostic (3.85e-1)" "unprognostic (1.96e-2)" "unprognostic (1.12e-1)" "unprognostic (1.52e-3)" "unprognostic (8.92e-2)" "unprognostic (1.13e-2)" "unprognostic (1.40e-1)" "unprognostic (4.56e-2)" 7.4 9.9 6.8 18.6 12.9 25.6 7.0 9.0 11.3 8.0 13.0 9.0 8.7 7.8 8.7 7.1 8.6 10.7 6.5 5.1 6.9 10.5 6.2 13.2 17.9 23.5 11.4 9.0 7.8 34.2 6.6 10.0 18.3 7.1 7.8 12.0 10.8 6.8 6.6 8.8 10.6 9.1 13.8 18.7 11.1 3.4 16.5 20.2 11.0 7.6 14.5 11.0 7.1 17.3 40.1 69.7 6.9 4.9 24.4 37.0 5.1 9.9 21.4 43.7 37.1 7.5 18.1 2.6 8.3 20.8 46.6 22.7 9.3 12.9 14.7 90.8 4.3 6.3 29.9 13.3 10.5 6.7 6.2 20.5 8.6 24.6 10.6 13.7 34.3 28.3 11.8 14.5 16.5 9.7 26.7 2.8 5.1 7.5 16.0 18.0 15.9 3.1 12.1 34.1 6.6 9.2 24.1 50.3 17.3 15.3 11.6 8.2 44.5 24.2 19.0 14.4 10.3 6.3 6.3 7.0 18.2 7.6 8.9 19.5 20.8 10.4 26.2 18.5 17.5 15.3 18.6 21.6 5.4 15.5 14.6 18.2 84.5 26.1 17.1 32.0 15.4 4.8 6.8 12.9 9.0 11.3 5.1 6.9 23.5 11.4 18.3 13.8 16.5 17.3 76.1 89.8 56.9 56.8 89.9 35.8 37.2 39.2 43.3 21.2 59.9 41.7 32.6 75.8 50.3 101.2 50.1 21.0 240.8 117.4 13.7 120.3 1.4 58.7 58.9 90.7 46.0 30.3 23.6 162.4 31.5 50.8 158.0 93.4 46.7 140.7 74.3 56.4 98.0 23.5 15.5 68.2 32.6 136.5 94.9 3.7 60.9 128.9 30.2 87.1 194.6 26.1 396.5 32.2 70.4 166.1 76.2 51.6 167.6 100.8 116.3 92.2 66.2 68.5 65.7 52.3 53.7 1.4 8.2 43.0 34.4 21.8 211.6 84.7 54.9 66.5 RNF216 "TRIAD3, UBCE7IP1, ZIN" ENSG00000011275 "Ring finger protein 216" Q9NWF9 7 5620047-5781696 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Host-virus interaction, Ubl conjugation pathway" Transferase "Disease variant, Hypogonadotropic hypogonadism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 145.5;Late spermatids: 257.6;Spermatocytes: 159.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018955, HPA021123" Supported Supported Nucleoplasm,Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 43: Testis - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" Cytosol Nucleoplasm "HPA018955: AB_1858500, HPA021123: AB_1858501" "unprognostic (3.31e-2)" "unprognostic (4.24e-2)" "unprognostic (1.28e-2)" "unprognostic (1.58e-2)" "unprognostic (1.81e-2)" "unprognostic (1.56e-1)" "prognostic unfavorable (2.26e-4)" "unprognostic (2.35e-1)" "unprognostic (2.40e-1)" "unprognostic (1.40e-2)" "prognostic favorable (6.24e-5)" "unprognostic (2.88e-2)" "unprognostic (9.01e-2)" "unprognostic (3.49e-1)" "unprognostic (1.73e-2)" "unprognostic (1.06e-2)" "unprognostic (3.69e-3)" 14.3 12.3 14.3 12.8 15.9 15.6 13.1 12.6 14.6 13.2 10.0 25.5 8.1 21.9 8.2 12.3 15.8 8.7 21.7 13.8 17.5 10.0 10.1 12.8 17.0 14.9 15.4 16.5 14.9 13.9 15.4 7.7 14.8 14.6 5.8 7.2 11.4 13.7 19.6 13.3 17.9 15.0 12.8 19.2 14.6 30.1 16.2 12.8 12.7 11.9 11.5 16.4 10.9 14.3 22.0 23.6 17.0 32.8 21.6 14.6 11.5 20.7 19.3 17.6 15.8 16.7 12.3 17.3 11.4 22.0 38.7 17.1 13.6 15.3 10.3 11.4 19.3 12.5 13.6 18.0 27.7 19.5 25.3 21.4 20.4 16.2 14.6 18.4 15.0 19.2 28.4 12.9 18.9 35.2 8.8 44.7 25.7 13.1 20.0 26.1 23.4 12.2 13.9 13.9 14.1 25.3 11.8 33.9 13.2 15.3 14.2 28.2 20.5 24.9 39.9 25.2 22.8 11.4 9.0 16.0 19.6 21.7 37.4 3.5 7.7 24.2 10.1 8.3 9.4 8.3 9.3 8.7 6.3 8.8 10.9 11.3 13.2 12.7 8.7 7.1 8.3 6.9 14.3 15.9 12.6 14.6 13.8 17.5 14.9 15.4 14.8 12.8 16.2 14.3 33.4 6.4 23.9 34.9 33.6 16.6 20.8 11.9 15.9 36.4 16.1 17.8 33.3 8.6 13.6 12.9 52.1 14.1 47.7 10.3 25.4 17.6 145.5 14.6 33.7 29.7 6.0 8.8 50.2 13.7 12.9 26.7 16.3 16.9 19.6 34.0 26.4 15.1 22.9 28.6 61.7 15.4 6.1 23.0 29.3 257.6 37.3 23.1 12.4 49.6 37.0 30.2 56.7 46.3 64.2 15.6 7.0 30.1 20.3 24.2 13.0 14.9 13.7 48.5 26.3 46.0 30.0 159.8 124.2 12.9 16.2 15.2 40.2 22.8 11.8 15.2 RNF217 "C6orf172, dJ84N20.1, IBRDC1, MGC26996" ENSG00000146373 "Ring finger protein 217" Q8TC41 6 124962545-125092633 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "parathyroid gland: 42.7" "Cell type enhanced" "Detected in many" "Early spermatids: 127.8;Oligodendrocytes: 102.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA029598 Uncertain NA NA "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 9: U-2 OS - Unknown function" "Cluster 23: Spermatids - Flagellum & Golgi organization" "HPA029598: AB_10602297" "unprognostic (2.96e-2)" "unprognostic (2.34e-3)" "unprognostic (8.07e-2)" "unprognostic (8.62e-2)" "unprognostic (1.94e-1)" "unprognostic (2.06e-2)" "unprognostic (1.06e-1)" "unprognostic (7.22e-3)" "unprognostic (4.94e-2)" "unprognostic (6.69e-2)" "unprognostic (2.47e-1)" "unprognostic (2.61e-1)" "prognostic unfavorable (4.60e-5)" "unprognostic (8.29e-4)" "unprognostic (2.16e-1)" "unprognostic (7.52e-2)" "prognostic unfavorable (1.92e-4)" 8.0 3.0 3.4 2.0 2.5 11.0 6.0 3.0 2.3 6.3 4.9 7.2 1.3 4.4 2.0 5.0 7.4 4.2 5.1 3.0 2.7 1.9 5.7 6.3 0.7 3.0 1.8 8.6 2.8 42.7 2.9 3.9 2.4 3.5 1.3 3.6 4.7 3.6 7.6 9.1 2.5 4.1 1.1 1.8 3.5 6.9 2.6 1.5 5.8 5.9 0.4 5.3 5.7 5.4 4.9 5.0 1.7 0.6 6.1 2.4 9.7 6.6 8.9 4.4 5.8 0.0 4.6 0.0 9.0 6.3 10.1 7.0 1.0 5.9 6.2 0.0 5.5 2.7 7.6 1.5 5.7 0.0 0.2 6.5 5.4 3.3 9.7 5.2 5.0 0.0 14.0 0.0 7.8 0.0 0.0 0.0 1.5 0.0 1.3 0.1 6.8 0.0 4.5 2.2 0.8 0.0 2.9 0.7 2.5 4.8 4.8 0.8 8.1 3.6 11.5 0.0 14.3 0.0 0.0 0.0 2.7 0.0 4.4 0.1 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.4 2.5 3.0 2.3 3.0 2.7 3.0 1.8 2.4 1.1 2.6 5.4 25.0 22.4 21.0 49.0 0.6 48.2 15.8 17.5 18.2 6.3 10.0 10.7 14.4 4.3 12.1 5.5 16.7 24.2 0.9 1.3 0.0 8.1 127.8 11.4 21.5 19.0 3.0 6.5 56.3 9.6 29.7 23.1 4.6 22.8 1.3 9.0 15.7 26.9 9.8 21.9 65.0 2.4 12.2 14.6 20.9 62.1 25.7 11.3 19.6 51.5 9.8 4.2 1.0 37.7 102.1 11.8 2.0 21.1 0.4 21.6 6.9 2.3 9.6 5.7 6.6 44.9 12.3 1.7 2.9 17.5 47.0 17.9 1.8 5.3 4.3 16.3 RNF220 "C1orf164, FLJ10597" ENSG00000187147 "Ring finger protein 220" Q5VTB9 1 44405194-44651724 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "brain: 121.3" "Cell type enriched" "Detected in all" 7 "Oligodendrocytes: 2136.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "U-937: 69.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027577, HPA027578" Approved Approved Nucleoplasm "Intracellular and membrane" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 32: U-937 - Innate immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "HPA027577: AB_2672339, HPA027578: AB_10601482" "unprognostic (3.12e-2)" "unprognostic (1.24e-1)" "unprognostic (3.49e-2)" "unprognostic (2.56e-1)" "unprognostic (2.94e-2)" "unprognostic (6.96e-3)" "prognostic unfavorable (2.35e-6)" "unprognostic (1.55e-1)" "unprognostic (8.47e-2)" "unprognostic (2.13e-1)" "unprognostic (2.14e-3)" "unprognostic (2.96e-2)" "prognostic unfavorable (5.12e-4)" "unprognostic (1.51e-2)" "unprognostic (1.98e-1)" "unprognostic (1.37e-3)" "unprognostic (6.46e-2)" 7.5 5.9 37.9 7.3 67.0 10.8 6.8 49.1 49.3 7.4 0.4 9.1 7.8 8.9 5.9 6.6 8.1 2.9 8.7 36.2 45.1 6.6 5.2 5.7 5.9 64.1 53.3 7.6 7.0 5.7 7.1 6.2 63.0 5.9 3.9 7.5 7.4 4.5 24.3 8.6 7.7 5.5 38.1 6.9 6.6 8.2 68.3 7.1 6.3 10.1 5.8 7.0 7.0 121.3 11.6 5.4 22.9 7.8 8.7 7.9 17.1 13.4 12.3 10.1 14.9 9.3 11.2 22.3 11.6 10.8 14.4 7.5 25.8 11.0 13.7 28.0 22.9 30.9 17.9 16.3 14.1 22.0 15.2 8.7 24.7 11.3 17.9 8.4 5.9 11.6 23.1 10.7 6.3 8.1 21.8 16.7 24.9 12.6 12.2 18.3 13.5 15.9 6.5 7.1 10.3 12.7 11.4 7.8 17.4 7.9 5.8 38.1 9.1 10.7 11.4 10.2 25.1 24.4 25.2 16.0 8.7 69.5 6.5 0.9 0.8 1.2 1.2 0.7 0.9 0.8 0.3 1.6 1.3 1.2 0.7 0.6 0.6 0.8 0.5 2.5 1.3 0.6 37.9 67.0 49.1 49.3 36.2 45.1 64.1 53.3 63.0 38.1 68.3 121.3 16.2 9.6 13.4 66.3 26.9 15.2 13.4 13.2 30.1 25.1 24.7 20.8 22.0 25.8 10.4 23.9 25.0 17.3 33.7 29.0 17.6 17.9 13.1 23.4 20.7 17.2 18.0 41.9 21.9 28.7 24.5 16.7 19.4 20.5 10.8 18.8 17.9 31.4 25.7 23.5 12.9 24.3 22.4 29.3 9.8 16.2 19.3 21.3 12.4 298.9 23.9 19.2 15.5 7.1 2136.9 25.3 20.9 13.9 26.1 22.5 26.5 35.6 8.2 18.3 6.6 23.5 14.8 30.6 31.3 25.1 17.5 10.1 26.1 17.6 26.7 20.5 RNF25 "AO7, FLJ13906" ENSG00000163481 "Ring finger protein 25" Q96BH1 2 218663892-218672002 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036420, HPA036421" Uncertain Approved "Nucleoplasm,Actin filaments,Cytosol" NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 80: Striated muscle - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 66: Spermatocytes - Spermatogenesis" Cytosol "Nucleoplasm, Actin filaments" "HPA036420: AB_2675114, HPA036421: AB_10669604" "unprognostic (3.22e-2)" "unprognostic (7.85e-3)" "unprognostic (1.34e-2)" "unprognostic (2.29e-2)" "unprognostic (1.33e-1)" "unprognostic (1.31e-1)" "prognostic unfavorable (6.58e-4)" "unprognostic (3.58e-2)" "unprognostic (2.67e-2)" "unprognostic (3.46e-1)" "unprognostic (2.04e-3)" "unprognostic (8.82e-2)" "unprognostic (1.26e-3)" "unprognostic (2.50e-1)" "unprognostic (1.37e-1)" "unprognostic (2.44e-1)" "unprognostic (6.69e-2)" 10.9 11.4 18.5 8.9 18.6 7.3 10.9 18.3 21.0 12.2 17.1 12.0 6.2 12.7 15.8 11.7 12.4 10.8 13.9 18.6 19.7 10.4 11.1 10.4 14.5 18.4 18.4 14.5 11.5 15.1 11.4 11.4 19.0 11.8 8.2 7.0 11.0 13.9 15.0 14.5 7.9 13.6 18.5 10.3 9.4 14.3 19.2 15.1 14.1 17.1 11.9 14.0 9.7 19.0 18.8 20.4 22.1 24.6 27.6 17.5 20.4 27.3 43.5 58.0 53.6 32.4 13.2 11.6 17.6 42.3 35.2 19.5 22.1 33.9 31.0 16.4 27.3 22.7 21.3 34.6 33.6 19.3 20.6 33.9 30.9 55.5 44.7 21.4 31.0 40.9 27.4 24.3 41.1 45.3 20.6 20.4 32.9 16.2 23.4 23.2 15.5 15.9 36.3 21.8 19.5 23.8 18.1 17.2 28.4 21.9 20.6 25.6 26.6 40.2 20.5 19.2 31.1 23.7 13.7 23.5 33.4 19.1 25.7 58.6 21.5 32.6 26.0 21.3 24.8 25.7 25.7 27.2 17.1 30.4 29.0 23.2 17.1 30.5 25.2 15.0 25.9 24.8 18.5 18.6 18.3 21.0 18.6 19.7 18.4 18.4 19.0 18.5 19.2 19.0 4.2 0.0 0.5 5.2 7.8 6.2 4.8 16.3 6.8 7.7 3.4 3.7 4.0 10.0 8.9 1.8 8.4 12.3 4.5 7.4 15.6 12.3 16.8 6.3 8.1 7.6 1.2 2.1 6.2 12.9 9.7 7.5 9.7 4.8 7.0 5.9 8.9 7.1 13.2 5.0 5.8 5.5 8.2 5.0 4.0 5.3 7.2 5.5 8.8 2.8 8.9 7.9 9.2 3.5 4.9 12.7 9.6 12.8 8.5 3.8 7.2 14.8 8.2 5.0 26.3 5.6 9.2 19.3 12.8 5.9 6.8 10.0 8.0 8.5 6.1 3.6 RNF26 MGC2642 ENSG00000173456 "Ring finger protein 26" Q9BY78 11 119334527-119337309 "Enzymes, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 66.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" HPA027620 Uncertain Approved Nucleoplasm,Vesicles,Cytosol NA Yes "Cluster 39: Non-specific - mRNA processing" "Cluster 85: Liver - Metabolism" "Cluster 1: K-562 - Erythropoiesis" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "Vesicles, Cytosol" "HPA027620: AB_1856356" "unprognostic (9.23e-3)" "unprognostic (3.54e-2)" "unprognostic (1.36e-1)" "unprognostic (8.68e-3)" "unprognostic (3.40e-1)" "unprognostic (1.07e-2)" "prognostic unfavorable (3.19e-4)" "unprognostic (2.14e-2)" "unprognostic (3.26e-1)" "unprognostic (1.69e-1)" "unprognostic (7.24e-3)" "unprognostic (6.22e-2)" "prognostic favorable (3.45e-6)" "unprognostic (9.61e-2)" "unprognostic (3.50e-2)" "unprognostic (4.41e-2)" "prognostic unfavorable (7.73e-4)" 14.3 15.8 12.7 11.5 12.6 22.0 13.3 13.7 15.1 15.4 10.6 19.2 14.5 23.5 10.3 20.9 16.6 10.5 13.2 12.7 12.5 13.6 23.6 12.4 11.8 15.2 13.1 17.1 13.8 18.5 10.4 14.2 15.5 14.8 12.6 8.4 14.9 18.6 8.5 15.7 17.0 19.0 12.7 14.6 19.1 15.1 14.7 13.3 13.2 7.1 12.8 18.9 14.2 13.1 43.8 47.4 43.4 51.4 41.8 32.8 46.0 46.3 49.7 52.8 41.5 80.6 88.9 38.3 62.5 55.5 80.1 77.2 61.9 69.8 33.0 46.0 34.2 101.0 21.8 67.3 31.9 42.8 40.4 34.3 35.2 66.1 59.0 34.7 40.8 58.1 50.0 58.4 36.9 94.9 39.5 44.3 43.5 50.2 59.8 40.5 44.5 30.4 32.7 31.1 30.8 29.9 37.4 46.8 12.5 41.4 106.1 35.4 27.0 63.5 41.8 33.7 43.0 14.0 24.6 0.4 21.3 71.0 50.6 9.5 21.6 5.6 20.8 19.2 13.4 11.1 15.7 18.4 19.0 16.7 17.5 15.5 1.5 14.0 20.2 11.0 8.7 24.9 12.7 12.6 13.7 15.1 12.7 12.5 15.2 13.1 15.5 12.7 14.7 13.1 5.1 3.2 9.4 1.0 9.1 6.9 13.3 15.4 12.5 9.2 10.9 9.8 0.8 22.8 11.1 11.0 2.1 44.0 6.2 9.3 5.9 20.8 6.6 5.9 7.9 8.6 13.8 18.5 3.2 17.0 66.0 11.5 9.2 5.9 7.6 16.9 11.4 23.4 21.5 5.0 2.9 13.0 8.2 14.8 5.9 8.6 14.0 6.6 1.8 1.0 11.6 11.6 15.5 4.5 2.7 14.1 7.5 17.7 4.3 14.2 15.6 12.5 4.8 9.4 6.6 6.5 10.6 19.9 10.5 14.3 8.5 24.4 8.3 8.8 18.6 9.8 RNF31 "FLJ10111, FLJ23501, HOIP, Paul, ZIBRA" ENSG00000092098 "Ring finger protein 31" Q96EP0 14 24146683-24160660 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 16.0;Excitatory neurons: 8.8;Gastric mucus-secreting cells: 7.7;Inhibitory neurons: 8.2;Microglial cells: 10.3;Oligodendrocyte precursor cells: 9.5;Plasma cells: 8.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "CAB009063, HPA048745" Approved Approved Cytosol NA NA "Cluster 15: NK-cells - Transcription" "Cluster 59: Non-specific - Translation" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 59: Non-specific - Transcription" Cytosol "CAB009063: AB_2127706, HPA048745: AB_2680509" "unprognostic (3.58e-2)" "unprognostic (5.22e-2)" "unprognostic (2.51e-2)" "unprognostic (9.05e-2)" "unprognostic (2.52e-1)" "unprognostic (6.24e-2)" "unprognostic (9.09e-3)" "unprognostic (1.55e-2)" "unprognostic (3.11e-3)" "unprognostic (1.96e-2)" "unprognostic (1.33e-1)" "unprognostic (2.46e-1)" "unprognostic (6.21e-3)" "unprognostic (1.15e-1)" "unprognostic (2.59e-1)" "unprognostic (1.41e-2)" "unprognostic (1.99e-1)" 14.3 18.5 4.9 9.1 4.8 9.5 14.3 4.2 6.6 16.7 3.6 15.0 7.1 18.2 6.9 16.2 14.8 6.9 19.6 4.6 4.1 17.5 15.8 14.9 10.4 5.3 4.4 17.8 23.9 10.4 18.7 6.9 4.5 16.6 6.6 4.1 16.9 7.1 41.5 19.3 15.9 9.6 4.5 26.1 17.9 16.4 4.8 11.7 16.5 17.9 9.6 15.1 14.0 4.4 6.1 10.8 10.5 14.8 6.1 6.3 23.2 9.9 15.1 18.2 15.6 10.2 13.5 10.9 6.9 11.8 10.2 7.6 5.4 11.8 9.7 13.2 4.2 11.0 9.5 32.5 12.8 17.5 18.8 12.3 10.4 7.2 12.9 9.6 12.0 7.9 5.9 12.9 7.7 17.3 17.6 8.6 5.3 9.9 12.7 10.1 9.8 6.8 8.9 20.8 9.9 12.7 8.6 25.6 12.5 9.2 7.4 13.3 11.1 12.6 10.2 8.8 8.9 21.4 21.2 11.5 4.4 6.1 13.6 0.0 0.8 0.8 0.6 1.7 1.8 0.4 0.9 0.6 0.5 0.4 0.6 0.4 1.7 1.7 1.0 1.8 1.1 0.4 4.9 4.8 4.2 6.6 4.6 4.1 5.3 4.4 4.5 4.5 4.8 4.4 0.9 0.0 4.6 16.0 5.2 0.6 0.3 0.0 4.6 0.6 1.0 0.3 0.3 0.0 3.1 0.0 0.0 0.6 1.0 0.8 0.0 0.3 0.1 1.0 1.3 1.3 0.0 3.8 8.8 0.0 0.5 1.3 7.7 0.9 0.0 1.1 0.4 0.8 0.4 0.0 8.2 0.3 2.0 0.6 1.5 0.4 0.3 2.7 0.0 10.3 0.5 0.3 3.1 9.5 7.3 0.2 0.2 0.0 8.7 0.2 0.5 0.2 0.8 0.8 0.0 1.4 1.2 1.6 0.8 5.7 0.9 0.5 4.3 0.8 0.1 0.3 RNF34 "FLJ21786, RIF, RIFF" ENSG00000170633 "Ring finger protein 34" Q969K3 12 121400041-121430623 "Enzymes, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 134.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA074151 Supported "Nucleoplasm,Nuclear bodies" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 80: Striated muscle - Unknown function" "Cluster 44: HDLM-2 - Immune response" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" Nucleoplasm "Nuclear bodies" "HPA074151: AB_2686668" "unprognostic (3.54e-1)" "unprognostic (4.83e-2)" "unprognostic (1.90e-1)" "unprognostic (6.10e-2)" "unprognostic (9.92e-2)" "unprognostic (2.55e-2)" "prognostic unfavorable (6.72e-8)" "unprognostic (3.39e-1)" "unprognostic (9.99e-2)" "unprognostic (1.60e-2)" "unprognostic (5.87e-3)" "unprognostic (2.80e-2)" "prognostic unfavorable (4.63e-4)" "unprognostic (1.09e-1)" "unprognostic (3.55e-1)" "unprognostic (5.55e-3)" "prognostic favorable (3.02e-4)" 13.7 10.8 25.5 23.6 29.7 13.4 13.4 31.6 32.2 11.6 21.8 19.2 19.5 13.7 13.5 14.9 12.5 17.3 18.4 26.8 28.6 11.3 13.0 12.9 34.3 26.0 26.6 14.7 13.8 13.3 13.7 11.5 26.7 10.5 15.6 19.0 13.9 13.5 59.5 15.7 18.3 16.7 24.7 23.3 18.4 24.6 26.6 26.8 13.9 36.8 26.4 19.0 11.9 32.7 45.4 53.8 34.7 36.3 26.8 24.5 43.2 47.5 42.2 46.3 35.3 67.3 16.9 64.9 35.3 51.3 24.6 31.8 52.6 29.8 41.0 95.3 30.8 75.4 37.7 62.5 32.1 65.7 50.4 21.9 39.6 40.2 34.7 26.4 49.3 37.9 58.0 29.3 46.0 35.7 57.5 95.7 44.5 26.6 48.4 54.0 45.1 38.1 32.0 53.2 50.7 33.0 59.4 21.8 36.6 31.6 38.0 49.1 39.5 39.5 28.4 34.6 37.8 51.2 92.8 70.5 28.2 45.4 40.6 83.7 42.1 91.2 72.4 48.4 74.1 77.1 83.2 76.8 40.4 65.0 71.1 71.1 65.2 76.2 53.3 34.3 106.3 68.3 25.5 29.7 31.6 32.2 26.8 28.6 26.0 26.6 26.7 24.7 26.6 32.7 14.5 16.0 16.2 15.3 22.9 17.5 18.7 23.4 13.6 13.9 16.5 13.2 22.0 27.1 18.9 9.2 4.2 26.1 30.9 19.0 37.2 32.7 23.5 13.7 15.3 17.3 40.8 24.8 34.3 27.3 38.8 16.1 15.8 13.9 17.7 19.0 17.2 11.2 21.2 13.5 32.7 15.8 30.5 18.0 14.9 10.7 17.1 14.0 17.8 13.1 35.0 23.6 46.4 9.5 45.5 26.2 17.2 18.0 27.9 17.0 20.5 19.9 18.7 21.4 19.7 11.1 25.0 134.0 73.9 15.3 16.1 24.2 34.3 18.5 21.2 25.7 RNF38 ENSG00000137075 "Ring finger protein 38" Q9H0F5 9 36336396-36487548 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 11 "Early spermatids: 503.1;Late spermatids: 1314.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA015853 Approved Supported Nucleoplasm NA NA "Cluster 38: Basophils - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 12: NES - Nervous system development" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "HPA015853: AB_1856365" "unprognostic (2.26e-1)" "unprognostic (2.49e-1)" "unprognostic (1.53e-1)" "unprognostic (8.16e-2)" "unprognostic (6.49e-2)" "unprognostic (3.65e-3)" "unprognostic (3.30e-3)" "unprognostic (1.64e-2)" "unprognostic (1.58e-1)" "unprognostic (9.69e-2)" "unprognostic (2.29e-1)" "unprognostic (4.15e-2)" "prognostic favorable (2.90e-6)" "unprognostic (3.88e-2)" "unprognostic (5.94e-2)" "unprognostic (1.46e-1)" "unprognostic (5.39e-2)" 15.8 11.9 10.5 13.2 10.9 37.8 17.2 15.6 15.1 17.3 5.2 19.9 10.5 23.4 19.6 15.9 17.8 11.8 15.8 11.0 10.7 19.2 11.3 18.9 18.4 9.2 11.5 36.7 20.5 15.7 6.6 20.5 9.7 17.6 15.8 23.9 14.1 19.1 12.7 12.1 13.3 22.9 8.6 19.5 10.7 68.4 11.4 21.3 22.5 19.6 18.5 16.7 12.9 9.4 14.4 8.0 30.5 18.2 13.7 12.6 29.8 8.8 11.0 10.6 13.8 13.8 7.8 21.6 9.1 17.1 14.0 5.5 19.6 10.3 16.3 19.3 8.4 26.2 11.6 13.6 10.6 19.4 22.9 13.0 10.9 13.4 12.9 17.6 27.4 21.0 5.5 20.2 17.4 5.0 20.1 10.2 20.5 9.5 5.7 18.3 13.8 12.0 18.1 16.4 12.7 13.6 10.0 9.9 10.0 35.5 9.6 19.6 27.2 10.1 15.2 6.0 10.6 13.2 29.6 15.0 9.2 16.1 13.2 10.7 2.9 5.0 4.4 2.7 3.6 3.5 4.0 4.7 2.7 3.7 4.2 4.3 5.3 5.9 2.8 2.2 5.9 3.1 10.5 10.9 15.6 15.1 11.0 10.7 9.2 11.5 9.7 8.6 11.4 9.4 32.8 12.8 11.7 80.6 16.8 17.3 10.9 8.7 14.8 16.5 21.9 15.2 15.9 10.0 11.5 7.3 18.8 13.2 29.9 19.6 9.8 11.2 503.1 13.1 14.6 25.0 16.8 9.0 71.2 12.0 11.9 14.4 14.8 16.7 6.3 20.5 24.7 16.6 11.4 26.9 72.8 12.8 10.2 27.0 23.7 1314.3 32.9 19.0 19.6 82.4 19.5 19.3 20.6 53.3 81.5 14.5 6.8 39.9 18.6 23.9 10.4 16.5 10.1 23.2 13.1 19.3 20.9 40.4 20.2 14.4 14.9 14.9 23.3 13.2 14.3 17.5 RNF4 "RES4-26, SLX5, SNURF" ENSG00000063978 "Ring finger protein 4" P78317 4 2462220-2625320 "Enzymes, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" "Activator, DNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA022047, HPA049356" Approved Supported "Nucleoplasm,Nuclear bodies,Microtubule ends" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 16: U-266 - Nucleosome" "Cluster 59: Non-specific - Transcription" "Nucleoplasm, Nuclear bodies" "Microtubule ends" "HPA022047: , HPA049356: AB_2680726" "unprognostic (8.38e-3)" "unprognostic (1.69e-1)" "unprognostic (1.29e-2)" "unprognostic (1.33e-1)" "unprognostic (1.45e-1)" "unprognostic (9.31e-3)" "unprognostic (9.03e-3)" "prognostic unfavorable (6.38e-4)" "unprognostic (1.34e-1)" "unprognostic (6.79e-2)" "unprognostic (2.58e-1)" "unprognostic (5.64e-2)" "unprognostic (1.93e-2)" "unprognostic (6.40e-2)" "unprognostic (4.70e-2)" "unprognostic (8.67e-2)" "unprognostic (1.54e-1)" 30.2 30.9 24.0 36.0 24.9 46.4 29.2 26.0 25.1 29.4 26.5 27.9 29.0 29.5 28.3 30.7 28.5 28.3 27.0 24.5 25.5 32.6 25.9 27.8 49.9 26.0 25.9 31.0 31.2 33.6 26.8 28.4 25.2 28.2 27.4 24.0 28.0 28.1 27.7 29.7 30.4 33.1 23.9 40.3 30.1 31.9 26.3 50.1 30.7 23.2 50.0 35.0 26.8 25.5 60.9 57.0 57.9 42.0 50.6 52.2 65.6 73.3 83.4 77.3 70.0 65.1 56.8 77.6 42.0 76.0 101.5 39.7 63.5 58.6 72.7 37.6 38.5 92.4 54.6 62.6 76.6 66.7 77.8 61.0 69.7 72.3 59.4 53.6 73.1 64.8 50.0 103.2 80.4 43.5 105.0 92.5 89.8 52.3 70.9 76.6 55.3 40.8 52.6 74.5 54.3 51.0 50.5 40.4 52.1 62.9 63.1 50.6 60.0 65.8 32.0 64.2 115.4 131.3 189.5 82.6 64.6 72.7 69.5 44.7 70.0 104.6 97.7 95.4 97.2 85.0 82.2 97.0 84.1 59.1 78.8 80.3 77.2 99.2 103.8 56.5 98.8 128.6 24.0 24.9 26.0 25.1 24.5 25.5 26.0 25.9 25.2 23.9 26.3 25.5 31.1 22.4 17.5 17.0 36.0 27.5 18.4 17.7 31.3 11.9 24.0 16.0 20.7 12.8 21.3 22.0 16.7 21.3 45.9 16.5 21.5 22.2 14.0 17.0 22.8 21.7 12.1 15.4 15.9 23.3 35.0 19.5 23.0 23.9 14.5 22.7 16.4 20.4 19.7 13.5 17.8 16.8 8.2 34.0 28.5 22.4 17.1 27.8 7.2 18.7 35.1 11.5 43.3 13.0 16.3 29.8 14.3 20.7 47.8 27.1 23.1 21.2 17.6 17.7 26.3 18.2 22.0 31.2 48.6 27.0 32.1 21.8 39.7 16.4 18.9 32.9 RNF40 "BRE1B, KIAA0661, RBP95, STARING" ENSG00000103549 "Ring finger protein 40" O75150 16 30761745-30776307 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Chromatin regulator, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal tubular cells: 88.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041330, HPA054227" Approved Supported Nucleoplasm NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 14: REH - Unknown function" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm "HPA041330: AB_10793872, HPA054227: AB_2682422" "unprognostic (1.61e-1)" "unprognostic (1.74e-2)" "unprognostic (3.06e-1)" "unprognostic (4.87e-2)" "unprognostic (1.21e-1)" "unprognostic (4.01e-1)" "unprognostic (5.97e-3)" "unprognostic (1.56e-1)" "unprognostic (1.50e-1)" "unprognostic (1.89e-1)" "unprognostic (2.16e-2)" "unprognostic (1.91e-2)" "prognostic favorable (8.11e-8)" "unprognostic (9.96e-2)" "unprognostic (1.36e-1)" "unprognostic (6.55e-3)" "unprognostic (6.60e-3)" 24.4 28.7 23.4 26.7 25.9 55.3 21.5 25.5 24.8 26.7 26.2 26.0 24.9 29.3 15.5 31.8 25.4 26.0 16.3 25.8 22.4 19.9 20.9 22.5 26.9 25.9 24.3 35.2 29.8 35.2 21.7 21.4 23.0 22.6 17.6 18.1 33.7 22.5 17.5 27.4 24.7 21.5 22.3 24.7 23.4 38.0 26.1 24.6 29.0 16.0 22.3 21.4 22.7 28.8 58.5 87.9 53.0 52.7 41.9 43.3 58.6 58.7 47.4 66.8 52.4 72.4 53.7 46.5 82.9 50.5 45.5 62.1 99.2 55.5 53.0 66.7 120.9 45.2 99.9 77.2 53.3 79.8 54.0 41.3 43.5 83.3 48.8 44.2 57.7 40.6 101.3 46.1 42.5 98.3 76.4 74.4 55.6 47.7 55.4 149.9 58.8 91.6 29.8 52.0 89.9 65.0 45.0 58.7 41.8 27.9 88.9 88.5 60.8 74.6 37.4 53.8 67.7 66.1 87.2 93.0 62.3 70.6 77.1 6.5 13.6 17.1 13.1 14.1 13.1 8.1 7.1 10.0 13.9 5.9 5.3 8.8 16.1 11.1 17.1 6.6 6.7 16.2 23.4 25.9 25.5 24.8 25.8 22.4 25.9 24.3 23.0 22.3 26.1 28.8 13.5 12.8 24.9 18.3 17.2 13.9 12.3 10.2 16.5 12.8 18.9 15.6 3.2 28.6 11.5 22.0 4.2 16.0 20.7 27.7 88.0 15.2 23.7 24.7 20.8 14.9 13.9 37.4 10.3 13.3 16.9 14.5 26.0 29.2 4.5 19.3 10.8 22.9 21.5 5.0 11.2 23.2 10.2 23.0 12.6 22.0 18.0 16.9 17.8 4.7 16.7 16.5 11.3 13.0 8.7 16.3 15.4 17.7 21.8 15.8 24.2 26.5 12.4 13.7 13.1 15.8 13.3 27.1 11.3 20.6 19.7 22.7 16.0 22.2 25.8 11.2 RNF41 "NRDP1, SBBI03" ENSG00000181852 "Ring finger protein 41" Q9H4P4 12 56202179-56221933 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Autophagy, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 92.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016812 Approved Approved "Nucleoplasm,Nuclear bodies,Midbody ring" Yes NA "Cluster 2: Granulocytes - Unknown function" "Cluster 38: Heart - Muscle contraction" "Cluster 30: Epithelial cell lines - Translation" "Cluster 57: B-cells - Immune response" "Nucleoplasm, Nuclear bodies" "Midbody ring" "HPA016812: AB_1856370" "unprognostic (1.14e-2)" "unprognostic (6.30e-2)" "unprognostic (4.04e-2)" "unprognostic (6.86e-2)" "unprognostic (9.59e-2)" "unprognostic (8.22e-2)" "prognostic unfavorable (6.49e-4)" "unprognostic (6.93e-2)" "unprognostic (4.18e-2)" "unprognostic (1.67e-1)" "unprognostic (5.80e-2)" "unprognostic (5.90e-2)" "prognostic favorable (2.52e-5)" "unprognostic (1.64e-1)" "unprognostic (1.65e-1)" "unprognostic (1.45e-1)" "unprognostic (1.43e-1)" 32.2 24.6 22.5 18.0 23.3 19.6 21.4 15.7 23.8 21.2 13.0 23.8 12.4 22.3 13.2 23.1 24.3 25.5 32.7 24.6 24.8 19.7 15.1 23.8 23.4 16.8 19.1 22.9 23.0 27.4 22.8 21.3 21.2 33.9 19.0 23.8 15.0 20.7 34.0 15.0 16.1 28.5 15.3 20.6 17.0 15.9 23.5 26.5 28.6 40.8 25.1 28.2 17.0 19.2 21.6 32.6 34.7 55.2 71.0 51.3 25.8 70.8 69.5 62.2 50.2 40.0 27.6 41.6 36.7 60.2 20.6 24.3 47.4 34.1 44.9 43.8 25.7 55.8 22.3 23.2 148.3 61.6 58.3 66.0 78.6 52.0 91.0 81.7 61.3 34.5 40.4 41.3 35.1 34.9 35.6 27.6 41.9 21.6 37.8 38.2 24.9 25.3 33.3 31.3 62.9 38.1 61.9 35.0 55.4 34.3 49.2 71.3 37.3 31.3 32.9 40.6 27.8 29.6 36.6 37.5 37.2 36.4 38.0 59.1 27.2 99.9 27.6 26.7 24.9 50.3 23.0 24.3 30.6 55.1 23.4 24.0 36.2 33.1 28.3 23.7 29.4 31.0 22.5 23.3 15.7 23.8 24.6 24.8 16.8 19.1 21.2 15.3 23.5 19.2 18.9 44.8 22.6 11.1 42.2 12.0 19.9 8.6 19.9 30.7 22.2 21.1 24.6 24.3 18.8 16.5 22.9 15.2 17.0 10.2 17.6 15.3 92.8 13.9 14.2 20.7 20.4 11.1 15.0 21.3 18.5 22.7 9.7 14.2 25.9 16.8 30.0 16.7 19.3 28.6 15.7 13.9 8.2 34.9 22.7 58.0 23.0 25.0 7.2 9.4 33.5 26.2 15.5 14.6 12.3 20.8 20.3 25.9 14.6 33.5 12.3 19.6 18.0 18.3 26.3 23.2 27.4 10.4 14.2 14.4 16.6 16.8 16.6 17.1 14.3 23.1 RNF43 "DKFZp781H0392, FLJ20315, URCC" ENSG00000108375 "Ring finger protein 43" Q68DV7 17 58353676-58417595 "Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted membrane proteins" "Ubl conjugation pathway, Wnt signaling pathway" "Developmental protein, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 22.7" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 67.7;Intestinal goblet cells: 41.6;Undifferentiated cells: 63.6" "Cancer enriched" "Detected in many" 4 "colorectal cancer: 41.7" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A549: 17.0;CACO-2: 24.7;Hep G2: 49.4;OE19: 54.7" HPA008079 Uncertain NA NA "Cluster 15: NK-cells - Transcription" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 21: OE19 - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA008079: AB_1856371" "unprognostic (2.53e-1)" "unprognostic (1.09e-1)" "unprognostic (7.46e-2)" "unprognostic (2.56e-1)" "unprognostic (1.10e-1)" "unprognostic (4.33e-2)" "unprognostic (1.39e-1)" "unprognostic (3.62e-1)" "unprognostic (2.93e-1)" "unprognostic (1.05e-1)" "unprognostic (5.69e-2)" "unprognostic (3.79e-1)" "prognostic favorable (6.04e-9)" "unprognostic (3.61e-3)" "unprognostic (2.56e-1)" "unprognostic (3.58e-1)" "unprognostic (1.04e-2)" 0.2 10.9 1.7 2.0 3.1 0.7 5.5 9.6 2.7 2.6 1.5 13.4 22.7 1.7 4.4 10.4 4.8 2.7 2.7 2.0 1.3 6.1 9.1 3.6 0.4 1.8 3.4 0.9 8.2 5.2 4.3 4.8 1.9 9.4 19.3 1.2 9.3 4.8 0.3 11.3 16.9 0.6 1.4 0.5 5.8 3.4 2.3 3.7 1.9 0.0 1.5 2.1 5.2 1.4 1.1 17.0 2.7 0.0 0.0 0.0 9.3 0.0 0.0 0.0 0.0 24.7 8.2 0.0 8.5 0.0 1.9 4.6 0.6 6.8 0.0 8.6 11.3 1.9 0.8 49.4 0.0 0.2 0.1 0.0 13.4 0.0 2.1 0.0 0.0 0.2 0.2 0.4 0.0 0.2 0.1 0.2 0.4 54.7 1.0 0.3 0.0 2.2 5.9 9.0 1.6 0.1 1.6 0.7 0.5 5.4 2.0 0.1 0.0 0.0 1.8 0.0 0.0 0.6 1.4 0.1 0.3 0.0 3.8 0.1 0.0 0.0 0.2 0.0 0.3 0.2 0.1 0.3 0.0 0.1 0.2 0.1 0.1 0.3 0.0 0.0 0.2 0.0 1.7 3.1 9.6 2.7 2.0 1.3 1.8 3.4 1.9 1.4 2.3 1.4 0.3 3.2 8.9 29.0 2.5 9.6 17.5 14.1 67.7 2.5 17.3 13.6 4.0 17.2 5.8 18.4 2.1 26.0 2.2 33.0 15.6 5.3 1.2 14.6 1.1 1.8 15.5 0.8 1.8 2.7 3.1 0.7 9.7 12.7 0.0 7.2 0.7 11.9 2.6 5.0 1.3 41.6 12.2 0.8 0.9 1.5 0.3 1.3 14.2 4.7 2.8 12.0 10.3 0.0 0.7 6.2 21.1 0.4 1.0 9.9 28.7 2.9 5.6 2.8 0.0 0.5 1.1 1.0 0.8 28.4 6.1 5.9 3.1 0.4 63.6 6.3 RNF5 "G16, NG2, RING5, RMA1" ENSG00000204308 "Ring finger protein 5" Q99942 6 32178405-32180793 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Proximal tubular cells: 371.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB034107, HPA065032" Uncertain Supported "Endoplasmic reticulum" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 43: THP-1 - Innate immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Endoplasmic reticulum" "CAB034107: AB_2238618, HPA065032: AB_2685408" "unprognostic (1.94e-1)" "unprognostic (1.31e-1)" "unprognostic (1.49e-1)" "unprognostic (4.45e-3)" "unprognostic (1.35e-2)" "unprognostic (1.23e-1)" "unprognostic (1.36e-1)" "unprognostic (1.37e-2)" "unprognostic (4.07e-1)" "prognostic favorable (2.44e-4)" "unprognostic (1.95e-1)" "unprognostic (8.93e-3)" "unprognostic (2.91e-3)" "unprognostic (8.84e-2)" "unprognostic (9.17e-2)" "unprognostic (2.72e-1)" "unprognostic (2.99e-2)" 38.2 75.9 60.4 29.2 63.4 40.4 44.5 64.6 66.0 44.9 59.4 59.5 61.6 44.8 45.8 37.5 54.1 46.1 81.7 59.2 60.6 115.6 126.2 38.7 43.1 65.0 60.6 60.4 41.6 55.5 17.2 30.1 62.6 44.0 62.4 42.9 43.9 31.7 89.6 44.6 76.5 30.5 62.8 38.8 55.3 29.5 61.8 60.7 48.6 76.5 43.4 45.1 38.8 67.0 51.2 66.1 43.7 167.5 46.9 31.3 34.0 20.6 26.5 44.4 48.7 89.1 42.1 65.2 70.8 47.9 62.5 41.7 80.3 45.1 45.2 41.8 107.5 53.9 69.5 184.4 55.0 0.2 101.2 32.3 60.3 73.3 53.6 77.2 89.1 115.0 136.6 67.8 63.8 71.9 66.5 151.5 0.3 71.8 28.7 44.4 48.2 88.2 124.0 32.6 44.8 92.1 39.9 42.4 46.7 39.9 87.0 183.0 40.3 48.1 44.7 0.5 79.1 38.6 63.5 79.3 33.2 116.4 29.6 64.8 45.7 75.8 64.8 65.9 55.6 64.6 52.5 57.6 64.7 56.2 57.5 58.3 22.1 79.6 46.7 264.6 58.2 75.0 60.4 63.4 64.6 66.0 59.2 60.6 65.0 60.6 62.6 62.8 61.8 67.0 38.3 19.2 41.1 2.9 52.7 95.7 70.0 146.6 52.3 23.6 61.8 56.5 62.9 87.2 79.5 92.0 0.0 78.1 70.3 151.9 283.7 110.8 21.6 47.2 31.7 50.9 73.2 126.3 3.4 91.3 101.7 44.6 28.5 31.7 56.3 41.5 47.8 131.5 68.9 33.7 3.5 83.0 132.2 51.1 171.7 22.6 59.4 43.3 85.4 1.0 69.5 91.3 65.9 1.5 10.0 78.5 173.0 72.6 45.5 58.4 270.6 371.6 73.4 27.6 65.7 50.6 63.0 55.7 37.7 44.4 84.4 84.1 53.8 42.8 100.3 56.5 RNF6 DKFZp686P0776 ENSG00000127870 "Ring finger protein 6" Q9Y252 13 26132115-26222314 "Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 99.1;Late spermatids: 191.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039343, HPA040048" Approved Supported "Nuclear membrane" NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 34: Non-specific - Transcription" "Cluster 30: Epithelial cell lines - Translation" "Cluster 31: Spermatids - Spermatogenesis" "Nuclear membrane" "HPA039343: AB_2676456, HPA040048: AB_10672969" "unprognostic (3.22e-1)" "prognostic unfavorable (3.07e-4)" "unprognostic (1.45e-1)" "unprognostic (1.63e-2)" "unprognostic (1.20e-1)" "unprognostic (1.68e-2)" "unprognostic (1.97e-1)" "unprognostic (4.07e-2)" "unprognostic (7.63e-2)" "unprognostic (6.13e-2)" "unprognostic (1.39e-1)" "unprognostic (4.21e-2)" "unprognostic (2.70e-2)" "unprognostic (8.35e-3)" "unprognostic (1.84e-1)" "unprognostic (7.70e-2)" "unprognostic (8.47e-2)" 18.9 17.3 12.4 18.7 13.3 32.5 17.9 13.4 18.4 13.4 13.5 18.4 17.5 12.4 13.7 18.5 14.5 13.7 13.7 13.9 11.7 18.2 16.6 16.2 22.4 10.4 13.5 11.5 14.1 22.3 10.7 19.9 11.5 16.0 18.5 26.6 13.5 13.9 21.2 17.3 18.8 15.7 10.8 19.7 17.2 33.6 13.7 25.3 17.5 15.3 23.8 18.3 10.1 11.5 33.3 28.9 10.7 15.8 36.3 28.2 23.9 56.3 45.2 35.4 24.9 36.4 41.8 59.5 27.3 53.5 31.5 43.7 30.2 45.3 58.4 57.7 19.2 64.8 23.9 31.3 56.6 68.7 65.4 26.8 86.1 39.8 84.2 34.3 36.0 25.5 25.6 0.1 55.3 30.0 38.5 39.8 8.7 59.5 19.8 30.4 41.5 23.7 43.6 43.3 19.3 11.9 29.9 54.0 54.1 24.8 20.7 66.3 47.6 30.4 18.6 41.1 40.5 14.8 14.9 34.9 27.8 38.4 40.7 46.6 14.5 34.7 15.6 18.4 17.1 18.6 17.1 17.7 17.6 12.5 16.8 14.8 9.7 20.0 23.3 9.1 19.2 14.2 12.4 13.3 13.4 18.4 13.9 11.7 10.4 13.5 11.5 10.8 13.7 11.5 20.9 22.4 19.8 6.8 26.5 30.5 12.7 17.5 14.8 22.2 15.1 10.5 13.5 5.7 19.7 7.3 25.0 20.2 31.6 24.8 33.2 15.1 99.1 37.4 16.9 23.0 11.4 24.8 14.4 15.4 21.8 16.1 17.3 19.9 26.6 12.1 17.5 12.3 17.5 30.3 17.2 15.5 24.4 22.4 19.9 191.0 14.6 23.0 14.2 12.2 21.6 24.9 29.9 11.6 16.2 24.4 20.1 11.3 18.0 22.0 15.8 21.4 40.1 43.2 26.3 21.6 14.5 83.5 29.1 19.2 29.1 42.1 26.2 17.1 12.6 23.5 RNF8 KIAA0646 ENSG00000112130 "Ring finger protein 8" O76064 6 37353979-37394734 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, DNA damage, DNA repair, Host-virus interaction, Mitosis, Ubl conjugation pathway" "Chromatin regulator, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-698: 76.0" "Not detected" "Not detected" "HPA050731, HPA064925" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 39: Non-specific - Mitochondria" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 51: Myeloid cells - Hemostasis" Nucleoplasm Cytosol "HPA050731: AB_2681222, HPA064925: AB_2685385" "unprognostic (1.80e-2)" "unprognostic (2.23e-1)" "unprognostic (1.39e-2)" "unprognostic (8.20e-2)" "unprognostic (5.17e-2)" "unprognostic (3.99e-2)" "prognostic unfavorable (3.33e-5)" "unprognostic (2.36e-2)" "prognostic unfavorable (1.91e-4)" "unprognostic (2.26e-3)" "unprognostic (3.38e-1)" "prognostic unfavorable (4.99e-5)" "unprognostic (7.95e-3)" "unprognostic (1.78e-1)" "unprognostic (3.41e-2)" "unprognostic (3.66e-3)" "unprognostic (1.09e-1)" 5.0 7.8 10.0 3.5 10.1 4.6 5.2 11.8 14.3 7.7 9.3 6.3 3.1 7.0 2.1 10.6 6.0 4.0 8.6 10.1 10.5 8.8 4.8 5.9 4.2 10.2 10.6 7.6 4.5 7.4 6.6 4.8 10.3 6.0 3.6 9.0 6.2 5.2 8.1 7.6 5.0 4.9 9.4 4.7 5.2 11.2 11.2 5.8 4.5 10.6 6.6 6.5 7.8 9.9 12.5 7.3 17.3 20.7 13.7 19.6 4.9 12.6 15.5 23.4 25.6 11.0 6.8 15.3 7.5 12.4 20.1 11.4 24.4 16.0 24.4 16.2 23.7 26.5 12.0 16.6 7.8 14.3 18.7 9.8 15.2 14.0 16.2 14.3 22.9 17.9 18.1 5.2 13.6 8.3 17.4 17.5 12.1 6.3 9.4 13.5 16.0 10.6 12.1 8.7 34.0 11.4 9.5 10.6 18.0 11.3 9.5 13.6 10.4 15.4 13.5 14.7 18.8 15.2 21.8 76.0 7.5 20.1 18.0 1.0 4.3 2.5 9.5 5.8 8.8 8.1 7.0 9.2 7.8 4.9 6.1 8.1 0.5 7.9 8.8 3.3 9.1 5.2 10.0 10.1 11.8 14.3 10.1 10.5 10.2 10.6 10.3 9.4 11.2 9.9 21.0 19.2 25.9 13.4 15.0 18.2 22.2 26.0 26.2 26.7 16.5 20.4 31.1 12.8 18.5 25.8 39.6 24.8 18.2 10.3 15.6 24.7 41.1 68.5 32.2 19.2 22.2 18.7 17.0 18.9 25.8 28.0 16.3 52.3 28.5 37.0 27.8 16.5 17.5 50.5 15.9 16.5 14.2 13.9 17.7 30.2 26.8 24.0 10.6 11.2 19.6 25.4 37.0 12.5 20.5 28.8 18.1 30.9 13.7 31.8 11.8 20.6 23.8 32.3 13.1 23.2 20.8 46.5 34.5 34.2 22.0 5.9 19.3 22.0 18.0 21.9 RNFT1 PTD016 ENSG00000189050 "Ring finger protein, transmembrane 1" Q5M7Z0 17 59952240-59964761 "Enzymes, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 64.9" "Cell type enhanced" "Detected in many" "Early spermatids: 174.8;Spermatocytes: 256.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA013739 Approved Nucleoli NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 83: Testis - Spermatogenesis" "Cluster 1: K-562 - Erythropoiesis" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoli "HPA013739: AB_1856382" "unprognostic (1.61e-1)" "unprognostic (2.83e-1)" "prognostic favorable (6.57e-4)" "unprognostic (3.04e-2)" "unprognostic (6.90e-2)" "unprognostic (2.16e-1)" "unprognostic (1.08e-2)" "prognostic favorable (7.48e-4)" "unprognostic (5.42e-2)" "unprognostic (3.45e-1)" "unprognostic (8.26e-3)" "unprognostic (9.44e-3)" "unprognostic (1.19e-3)" "unprognostic (1.44e-2)" "unprognostic (2.05e-1)" "prognostic favorable (2.57e-4)" "unprognostic (2.60e-1)" 6.4 7.2 1.1 6.5 1.1 5.6 4.2 1.5 1.6 4.1 1.9 6.1 8.0 2.6 11.3 3.4 2.6 4.1 3.5 1.1 1.3 4.9 17.4 6.7 6.7 1.6 1.2 2.6 5.6 6.9 1.7 6.2 1.3 4.4 7.1 1.6 4.8 2.2 3.6 3.1 7.1 4.4 1.2 4.0 3.7 64.9 1.4 5.0 5.4 2.1 7.4 7.3 1.8 1.2 7.1 3.2 3.5 4.4 12.6 8.3 6.3 8.6 5.5 8.1 9.3 9.5 2.7 10.9 14.2 8.1 16.0 8.0 11.7 6.9 11.9 9.7 11.2 9.2 7.2 9.3 8.0 13.3 13.1 9.6 3.9 7.0 3.3 3.7 7.7 3.0 23.7 6.3 6.1 8.5 6.0 6.2 1.2 10.9 7.6 7.6 24.1 5.7 5.5 4.9 2.0 3.8 12.0 3.0 17.2 4.9 14.3 25.8 4.8 12.6 11.1 7.2 7.7 9.3 26.4 6.0 8.8 7.7 6.5 32.5 17.3 31.4 7.6 21.8 10.7 14.3 7.2 8.8 15.5 8.8 9.1 8.3 8.6 13.9 28.0 9.9 9.9 11.9 1.1 1.1 1.5 1.6 1.1 1.3 1.6 1.2 1.3 1.2 1.4 1.2 12.5 0.0 7.4 5.5 23.3 11.3 14.5 15.1 9.6 9.5 13.4 10.2 6.3 4.3 12.4 9.2 20.9 36.1 23.2 17.0 5.9 14.0 174.8 12.5 9.3 7.5 4.2 13.3 24.7 14.4 36.4 16.6 12.8 8.4 19.0 24.5 13.2 29.5 44.5 18.5 19.7 7.6 12.2 24.5 16.6 77.3 9.0 26.6 17.8 23.4 35.1 4.9 16.5 14.6 8.0 13.3 25.0 11.7 14.1 9.3 17.2 10.4 23.0 8.6 19.7 8.2 11.0 256.4 44.2 15.8 9.7 28.9 16.8 12.5 11.4 10.2 RNGTT "hCAP, HCE, HCE1" ENSG00000111880 "RNA guanylyltransferase and 5'-phosphatase" O60942 6 88609897-88963618 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction, mRNA capping, mRNA processing" "Hydrolase, Multifunctional enzyme, Nucleotidyltransferase, Protein phosphatase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 108.6;Inhibitory neurons: 110.2;Oligodendrocyte precursor cells: 96.5;Oligodendrocytes: 94.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003750 Approved Approved Nucleoplasm NA NA "Cluster 19: B-cells - Humoral immune response" "Cluster 34: Non-specific - Transcription" "Cluster 1: K-562 - Erythropoiesis" "Cluster 57: B-cells - Immune response" Nucleoplasm "HPA003750: AB_1856383" "unprognostic (5.19e-3)" "unprognostic (1.00e-1)" "unprognostic (2.82e-2)" "unprognostic (3.45e-3)" "unprognostic (4.82e-2)" "unprognostic (1.10e-1)" "prognostic unfavorable (1.37e-4)" "unprognostic (4.48e-3)" "unprognostic (1.28e-1)" "unprognostic (4.05e-3)" "unprognostic (3.76e-2)" "unprognostic (1.55e-1)" "unprognostic (2.23e-3)" "unprognostic (9.83e-2)" "unprognostic (6.55e-2)" "unprognostic (1.67e-1)" "unprognostic (8.08e-3)" 5.3 6.7 4.9 8.2 4.9 9.5 5.6 9.1 5.7 5.2 2.6 4.6 4.2 5.2 3.6 7.2 4.1 3.7 5.3 5.1 7.0 5.3 6.9 4.4 17.2 4.6 5.2 4.8 2.9 6.4 4.9 5.0 5.1 5.3 5.4 10.6 3.5 4.9 5.2 4.4 5.2 6.1 4.6 7.6 4.2 9.3 7.3 14.7 5.6 6.4 17.3 6.2 4.8 5.3 9.2 14.0 21.1 26.2 12.0 12.6 12.4 20.2 13.4 16.4 20.4 15.9 6.8 23.1 16.2 14.9 21.5 11.1 24.7 16.5 29.7 31.8 19.0 30.5 11.4 12.2 9.5 33.2 16.6 7.7 13.8 16.8 15.9 13.6 14.7 12.7 30.9 18.1 23.8 12.0 14.6 22.8 12.5 15.0 11.7 28.6 32.0 13.3 14.0 14.2 12.3 17.3 16.8 9.8 11.1 19.7 10.8 31.8 11.5 13.0 12.0 14.7 27.9 16.1 31.6 13.2 18.9 23.8 24.1 5.2 4.1 7.6 7.8 5.9 7.8 22.9 8.6 9.7 5.8 22.8 9.7 10.1 3.4 10.9 5.5 4.0 9.0 5.4 4.9 4.9 9.1 5.7 5.1 7.0 4.6 5.2 5.1 4.6 7.3 5.3 8.9 0.0 16.2 54.5 60.4 8.3 10.7 6.0 10.8 22.4 6.5 6.1 10.7 7.2 12.9 12.9 39.6 10.4 19.7 8.0 0.0 6.3 17.9 7.9 12.1 7.0 9.1 7.6 108.6 4.9 9.9 9.7 15.8 12.4 8.8 11.0 7.5 10.3 7.8 15.2 110.2 7.0 4.1 9.1 7.3 5.2 5.9 13.6 3.6 69.3 9.8 7.2 18.6 96.5 94.3 7.2 5.1 7.9 42.3 8.6 4.6 6.3 10.1 43.4 6.6 15.8 9.5 23.3 20.1 10.7 8.7 11.8 24.6 8.0 6.7 7.4 RNMT RG7MT1 ENSG00000101654 "RNA guanine-7 methyltransferase" O43148 18 13726660-13764556 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "mRNA capping, mRNA processing" "Methyltransferase, RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039409 Approved Supported "Nucleoplasm,Nucleoli fibrillar center" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 52: Non-specific - Transcription" Nucleoplasm "Nucleoli fibrillar center" "HPA039409: AB_10795289" "unprognostic (3.02e-1)" "unprognostic (1.07e-2)" "unprognostic (3.48e-1)" "unprognostic (1.71e-3)" "unprognostic (3.57e-1)" "unprognostic (3.04e-1)" "unprognostic (6.17e-3)" "unprognostic (1.43e-1)" "unprognostic (3.76e-2)" "unprognostic (1.42e-3)" "unprognostic (9.45e-2)" "unprognostic (9.15e-2)" "unprognostic (1.00e-1)" "unprognostic (1.25e-1)" "unprognostic (1.56e-1)" "unprognostic (2.77e-2)" "unprognostic (1.78e-1)" 10.9 9.6 11.8 12.6 12.1 43.3 15.3 12.2 13.0 11.3 17.2 11.6 8.5 14.0 11.5 11.3 11.2 9.0 20.3 12.1 14.2 11.6 11.2 9.5 14.4 13.6 15.2 17.2 12.1 13.0 13.9 15.2 14.8 11.6 10.4 27.4 12.1 10.5 18.4 14.2 10.5 12.5 10.9 12.1 10.6 16.7 11.7 14.9 17.5 15.6 15.2 11.4 10.7 12.6 24.9 14.4 27.4 20.9 20.0 25.1 19.2 19.9 24.7 20.3 27.4 17.3 11.7 27.7 23.9 20.6 31.6 9.8 32.7 28.6 34.0 15.4 17.6 21.0 14.8 16.4 21.9 54.9 17.1 19.4 30.5 21.4 59.9 26.6 15.9 31.1 31.8 26.9 23.3 15.4 35.2 19.7 21.0 50.1 11.2 22.7 29.0 37.9 18.6 19.2 21.1 31.7 22.5 16.4 38.1 27.8 14.3 22.6 16.5 40.6 56.8 33.3 21.5 53.8 63.6 56.9 29.9 20.8 20.6 45.1 17.6 12.8 16.7 14.6 13.6 23.9 15.8 14.2 11.8 25.7 20.5 16.2 9.8 14.1 17.3 29.5 19.0 5.6 11.8 12.1 12.2 13.0 12.1 14.2 13.6 15.2 14.8 10.9 11.7 12.6 62.5 73.7 29.9 48.6 148.5 70.4 67.3 97.9 75.1 115.6 50.7 56.1 56.5 35.8 56.5 46.0 123.0 66.3 143.4 46.5 68.4 51.0 75.4 85.2 88.3 43.7 74.8 37.4 75.3 48.0 59.2 71.6 66.3 113.9 34.9 85.6 40.7 38.5 39.8 106.0 83.9 56.3 85.5 59.4 63.6 21.1 72.7 78.8 49.8 45.0 68.0 51.0 60.8 56.8 78.9 56.1 47.0 60.9 99.7 72.3 49.0 64.8 48.0 148.3 39.5 85.6 60.0 111.4 115.1 50.7 68.3 126.4 113.1 48.8 50.0 50.3 ROCK1 p160ROCK ENSG00000067900 "Rho associated coiled-coil containing protein kinase 1" Q13464 18 20946906-21111813 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 406.2;Late spermatids: 505.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004562, HPA007567, HPA045639" Approved NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 32: U-937 - Innate immune response" "Cluster 10: Non-specific - Unknown function" "CAB004562: AB_628223, HPA007567: AB_1856393, HPA045639: AB_2679401" "unprognostic (7.86e-2)" "unprognostic (2.86e-2)" "unprognostic (1.22e-1)" "unprognostic (6.63e-2)" "unprognostic (9.90e-2)" "unprognostic (1.17e-1)" "unprognostic (6.74e-2)" "unprognostic (1.00e-1)" "unprognostic (1.63e-1)" "unprognostic (8.89e-3)" "prognostic unfavorable (9.93e-4)" "unprognostic (3.85e-2)" "unprognostic (8.93e-3)" "unprognostic (3.04e-2)" "unprognostic (5.47e-2)" "unprognostic (3.19e-1)" "unprognostic (1.28e-1)" 8.0 4.2 3.8 5.7 4.8 18.2 6.0 4.4 3.9 5.3 4.6 5.0 3.6 5.9 4.6 4.2 6.3 4.2 5.5 2.8 3.5 4.4 4.8 7.6 5.5 5.4 4.0 5.4 5.1 2.9 2.9 4.4 4.9 4.4 3.2 4.8 4.4 3.4 2.6 3.7 5.2 3.2 4.4 6.2 5.8 2.6 4.5 5.5 4.5 1.9 4.2 6.6 5.4 5.3 6.5 3.9 3.9 3.8 7.2 7.7 6.3 8.9 4.3 3.9 4.2 6.6 2.7 8.0 6.2 10.5 2.1 5.2 3.6 5.2 7.8 11.4 4.1 6.4 7.3 2.9 3.6 17.9 9.6 5.6 4.6 5.8 4.7 3.2 6.0 3.1 3.7 7.9 4.6 4.1 8.5 3.8 3.2 4.3 6.6 11.9 4.5 3.1 3.7 5.9 4.5 3.5 7.1 4.6 3.6 3.4 4.6 6.7 9.9 7.7 6.4 7.1 7.2 10.7 5.3 9.0 5.8 7.5 4.8 3.0 5.0 6.8 5.0 3.2 4.0 3.9 3.6 3.8 4.2 5.0 3.5 3.5 18.0 2.8 4.0 5.5 3.6 2.5 3.8 4.8 4.4 3.9 2.8 3.5 5.4 4.0 4.9 4.4 4.5 5.3 98.2 96.1 88.7 64.6 112.6 46.3 60.4 30.7 43.9 100.4 32.2 35.6 138.6 28.6 61.4 33.1 131.3 57.5 136.9 36.6 15.6 62.5 406.2 64.8 86.9 94.4 99.0 47.9 81.3 38.0 64.9 78.4 62.7 73.8 72.7 68.5 60.0 47.4 60.3 60.6 74.2 45.8 40.7 135.3 126.7 505.0 97.6 166.2 65.8 106.8 137.1 52.3 204.9 87.0 140.0 70.9 62.8 138.8 83.2 63.2 32.3 21.0 44.6 128.6 170.9 81.4 197.6 107.4 80.9 38.7 36.7 43.0 127.4 70.5 38.9 73.3 ROCK2 ENSG00000134318 "Rho associated coiled-coil containing protein kinase 2" O75116 2 11179759-11348330 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Biological rhythms" "Kinase, Serine/threonine-protein kinase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "Excitatory neurons: 280.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007459, CAB008666, HPA044109" Approved Supported Cytosol NA NA 710000 "Cluster 15: NK-cells - Transcription" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 48: Smooth muscle cells - ECM organization" Cytosol "CAB008666: AB_1622617, HPA007459: AB_1079828, HPA044109: AB_2678813" "unprognostic (4.55e-2)" "unprognostic (1.05e-2)" "unprognostic (4.18e-3)" "unprognostic (4.87e-2)" "unprognostic (1.49e-1)" "unprognostic (2.71e-1)" "unprognostic (1.39e-2)" "unprognostic (2.72e-1)" "unprognostic (3.62e-2)" "unprognostic (6.66e-2)" "unprognostic (3.83e-2)" "unprognostic (1.48e-1)" "prognostic unfavorable (1.57e-5)" "unprognostic (1.51e-1)" "unprognostic (1.99e-1)" "unprognostic (2.52e-2)" "unprognostic (3.47e-2)" 36.4 9.3 6.7 13.5 16.3 6.8 22.3 19.1 14.3 18.7 0.8 22.6 16.7 22.0 10.3 16.2 13.6 15.6 17.0 12.1 3.5 14.5 16.5 16.9 10.1 1.7 4.4 19.0 11.7 12.8 5.9 24.9 1.4 17.4 26.2 13.5 14.6 18.1 30.4 8.5 19.2 27.9 2.0 16.4 14.1 7.8 6.4 8.4 13.9 28.9 8.8 21.1 11.0 10.4 17.5 41.7 33.8 33.2 59.7 41.6 21.6 40.4 37.7 25.8 27.1 39.8 37.2 21.9 23.4 64.5 31.3 18.9 24.7 23.4 40.6 31.2 14.7 43.8 70.6 79.7 21.4 24.7 12.1 32.6 14.6 31.9 22.6 21.0 42.0 11.9 38.6 8.6 38.8 14.8 18.2 12.7 18.8 36.9 25.3 21.7 74.2 7.0 14.0 48.8 15.9 16.9 79.6 27.4 27.4 25.5 11.3 13.6 57.3 52.9 38.2 21.2 36.0 6.8 8.9 18.8 22.8 28.2 75.4 0.9 0.4 0.4 0.6 0.4 0.7 0.3 0.4 0.4 0.3 0.5 0.4 0.4 0.6 0.8 0.4 0.6 0.4 0.2 6.7 16.3 19.1 14.3 12.1 3.5 1.7 4.4 1.4 2.0 6.4 10.4 114.5 115.4 79.1 81.3 16.0 39.9 43.0 15.3 21.1 35.7 33.5 41.1 107.0 37.1 53.1 22.0 58.4 26.3 20.4 97.7 1.9 27.1 11.0 53.6 141.2 90.3 21.2 22.5 280.4 39.5 19.1 64.0 18.3 55.3 29.0 36.9 56.0 43.1 19.6 80.8 158.1 92.2 10.2 20.3 27.0 4.9 43.8 30.4 23.2 107.7 20.6 38.4 15.5 99.0 66.9 39.1 43.6 78.6 16.2 53.5 45.3 15.7 32.7 48.5 131.5 70.0 118.5 30.3 24.6 19.9 27.8 31.5 18.5 34.2 54.8 40.7 ROR2 "BDB, BDB1, NTRKR2" ENSG00000169071 "Receptor tyrosine kinase like orphan receptor 2" Q01974 9 91563091-91950228 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Wnt signaling pathway" "Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Disease variant, Dwarfism" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 18.4;Endometrial stromal cells: 19.3;Fibroblasts: 14.4;Inhibitory neurons: 18.6;Microglial cells: 15.9;Oligodendrocyte precursor cells: 27.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Immune cell enriched" "Detected in single" 6 "MAIT T-cell: 1.0" "Lineage enriched" "Detected in single" 6 "T-cells: 1.0" "Cell line enhanced" "Detected in many" "AF22: 24.5;HHSteC: 63.1;HSkMC: 52.2;U-266/70: 38.3;U-266/84: 27.5" "Low region specificity" "Detected in single" "Group enriched" "Detected in some" 7 "cerebellum: 7.2;spinal cord: 3.7" HPA021868 Uncertain NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 12: Smooth muscle tissue - Mixed function" "Cluster 29: U-266 - Adaptive immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA021868: AB_1856406" "unprognostic (9.38e-3)" "unprognostic (4.69e-1)" "unprognostic (2.26e-1)" "unprognostic (8.48e-3)" "unprognostic (1.23e-1)" "unprognostic (2.38e-1)" "unprognostic (2.06e-1)" "unprognostic (1.31e-1)" "unprognostic (8.03e-2)" "unprognostic (2.03e-1)" "unprognostic (5.76e-2)" "unprognostic (2.66e-1)" "prognostic unfavorable (9.86e-7)" "unprognostic (2.16e-3)" "unprognostic (9.13e-2)" "prognostic unfavorable (4.28e-8)" "unprognostic (1.25e-2)" 6.9 5.7 0.8 3.9 0.6 0.1 4.4 0.4 0.5 18.7 28.2 32.7 2.2 23.7 1.5 8.2 11.6 8.6 11.1 1.4 0.8 1.4 0.5 5.5 0.5 1.7 2.1 13.9 1.6 16.6 1.6 3.5 0.9 13.9 2.2 1.0 1.6 13.3 0.3 4.2 7.7 11.0 1.2 3.3 12.8 3.4 1.2 3.0 5.6 0.7 1.0 17.5 10.6 0.7 0.0 0.2 24.5 0.0 5.3 0.5 6.8 0.4 6.3 4.0 7.8 0.0 0.0 0.0 0.1 0.8 3.9 0.2 5.2 0.0 1.7 0.0 4.2 0.0 18.3 0.0 63.1 0.0 0.0 52.2 0.0 5.6 0.0 0.0 0.0 0.2 14.7 0.0 0.0 0.4 0.1 3.6 3.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 7.2 0.6 0.0 0.0 5.0 14.8 0.0 0.0 0.0 4.8 2.0 0.0 38.3 27.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.6 0.4 0.5 1.4 0.8 1.7 2.1 0.9 1.2 1.2 0.7 0.3 0.0 0.0 1.6 0.1 3.1 11.3 0.9 1.2 1.4 3.7 3.0 8.2 1.5 0.2 0.0 0.0 0.4 0.0 0.5 0.0 2.5 4.5 18.4 19.3 1.4 3.0 0.0 1.4 1.5 0.2 14.4 2.6 7.5 1.3 0.1 0.4 0.0 0.8 0.0 18.6 2.8 0.0 0.0 4.8 8.6 5.9 0.4 5.4 15.9 1.6 7.4 0.0 27.6 0.4 0.6 1.6 9.1 0.1 8.6 0.0 0.0 0.2 0.5 6.6 0.0 2.9 2.3 14.3 0.1 2.3 0.4 0.7 0.4 0.8 5.3 ROS1 "c-ros-1, MCF3, ROS" ENSG00000047936 "ROS proto-oncogene 1, receptor tyrosine kinase" P08922 6 117287353-117425942 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 18 "epididymis: 58.6;lung: 31.7" "Cell type enriched" "Detected in some" 4 "Alveolar cells type 2: 78.5" "Cancer enriched" "Detected in some" 13 "lung cancer: 6.9" "Region enriched" "Detected in single" 4 "cerebral cortex: 2.4" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "GAMG: 19.3;HSkMC: 10.1;hTCEpi: 21.7;LHCN-M2: 14.9" "Not detected" "Not detected" "Not detected" "Not detected" "HPA049098, HPA072424" Uncertain Approved Vesicles NA NA "Cluster 30: Epididymis - Antimicrobial activity" "Cluster 30: Epithelial cell lines - Translation" "Cluster 11: Alveolar cells - Smell perception" Vesicles "HPA049098: AB_2680628, HPA072424: AB_2686519" "unprognostic (8.18e-2)" "unprognostic (4.64e-3)" "unprognostic (1.60e-1)" "unprognostic (2.37e-2)" "unprognostic (7.57e-2)" "unprognostic (2.05e-2)" "unprognostic (1.57e-1)" "unprognostic (1.79e-1)" "unprognostic (2.79e-2)" "unprognostic (1.00e-2)" "unprognostic (2.42e-1)" "unprognostic (5.20e-2)" "unprognostic (1.56e-12)" "unprognostic (1.09e-2)" "unprognostic (2.81e-1)" "unprognostic (1.91e-1)" "unprognostic (2.12e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.2 0.0 0.4 0.0 0.0 58.6 0.0 0.1 0.0 0.0 0.6 0.0 0.3 0.1 31.7 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.4 0.0 0.0 0.4 0.0 0.0 2.2 0.4 0.3 0.2 0.0 0.0 0.0 0.2 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 19.3 0.3 0.0 0.0 0.1 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 10.1 21.7 0.2 1.9 0.0 0.0 0.0 0.0 0.0 14.9 0.0 0.0 0.2 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 2.0 0.0 3.1 1.7 0.2 2.1 0.0 0.0 0.0 1.9 3.5 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 16.0 78.5 0.3 0.0 0.0 0.0 0.3 0.0 0.0 0.6 0.0 0.8 0.0 3.7 0.0 0.0 0.0 0.0 0.3 0.0 0.0 1.3 1.8 0.2 0.0 0.0 0.0 17.8 0.0 0.0 0.2 0.0 1.5 1.3 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 1.3 0.0 0.1 0.0 1.0 0.0 0.0 0.0 0.5 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 RPS6KA1 "HU-1, MAPKAPK1, p90Rsk, RSK1" ENSG00000117676 "Ribosomal protein S6 kinase A1" Q15418 1 26529761-26575030 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 91.1;monocytes: 81.2;NK-cells: 88.6;Proximal enterocytes: 93.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HMC-1: 77.6;U-937: 86.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003852, HPA007981" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 64: Macrophages - Immune response" "Cluster 32: U-937 - Innate immune response" "Cluster 63: NK-cells & T-cells - Immune response" Cytosol Nucleoplasm "CAB003852: AB_289590, HPA007981: AB_1079850" "unprognostic (1.04e-3)" "unprognostic (1.23e-1)" "unprognostic (1.61e-3)" "prognostic favorable (7.20e-7)" "unprognostic (7.35e-2)" "unprognostic (3.69e-1)" "unprognostic (6.93e-3)" "unprognostic (1.12e-2)" "unprognostic (1.09e-1)" "unprognostic (7.51e-3)" "unprognostic (2.37e-2)" "unprognostic (9.64e-2)" "prognostic favorable (1.84e-4)" "prognostic favorable (4.58e-4)" "unprognostic (4.77e-2)" "unprognostic (7.61e-2)" "prognostic favorable (8.33e-4)" 7.4 17.0 7.8 17.5 9.1 23.8 8.3 9.2 9.3 6.0 11.2 37.9 33.1 3.0 1.2 16.9 7.9 5.5 3.8 7.9 9.1 26.2 10.5 33.7 20.2 10.8 9.5 1.9 19.4 12.5 13.4 4.0 10.1 17.2 20.7 1.4 21.5 4.5 1.7 17.8 51.4 3.6 9.4 47.1 20.6 5.4 10.4 11.4 24.5 1.9 20.7 9.0 9.6 11.6 27.1 9.3 7.5 9.9 0.4 0.1 9.9 2.2 4.2 11.0 10.6 10.8 21.9 50.2 11.9 1.3 13.3 31.0 16.9 61.0 7.8 41.8 11.0 55.3 21.6 19.5 3.4 65.8 77.6 1.8 22.1 10.1 18.0 5.0 4.9 19.7 9.6 17.7 0.6 15.0 2.4 64.3 19.1 52.2 29.2 34.8 9.5 22.0 31.7 7.3 10.7 4.4 18.7 17.5 8.4 7.8 11.2 55.5 3.2 0.5 13.9 1.8 9.2 10.9 14.0 27.5 6.5 86.8 10.8 37.6 57.9 131.2 24.2 52.1 20.3 14.2 17.9 21.6 68.8 15.7 11.3 15.8 108.2 26.4 58.4 26.9 19.0 65.2 7.8 9.1 9.2 9.3 7.9 9.1 10.8 9.5 10.1 9.4 10.4 11.6 2.8 16.0 25.0 0.0 23.7 18.6 8.1 19.9 16.5 1.5 12.0 10.4 1.3 11.5 7.7 9.2 4.2 1.6 53.9 91.1 7.9 16.3 1.9 19.9 2.2 6.9 16.3 29.5 1.4 18.7 17.5 1.8 18.3 20.7 31.8 3.3 7.9 3.4 47.5 0.0 2.6 41.6 12.2 53.0 14.2 1.4 0.0 44.1 1.8 12.2 81.2 0.6 88.6 1.0 12.3 28.1 41.9 0.0 14.2 18.8 93.3 17.2 13.6 1.8 6.6 0.8 2.7 1.6 3.4 10.9 11.6 4.1 36.3 2.0 43.6 9.1 RPS6KA2 "HU-2, RSK3" ENSG00000071242 "Ribosomal protein S6 kinase A2" Q15349 6 166409364-166906451 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 399.6;Excitatory neurons: 204.1;Horizontal cells: 287.7;Inhibitory neurons: 552.3;Oligodendrocyte precursor cells: 244.8" "Cancer enhanced" "Detected in all" "thyroid cancer: 26.9" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 5 "eosinophil: 22.4" "Lineage enriched" "Detected in many" 5 "granulocytes: 22.4" "Cell line enhanced" "Detected in many" "ASC diff: 214.5;ASC TERT1: 156.1;HHSteC: 158.5;HSkMC: 141.4;hTERT-HME1: 173.0;hTERT-RPE1: 316.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB026243, HPA045061, HPA054237, CAB069428" Approved Supported Nucleoplasm NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "CAB026243: , CAB069428: AB_1622639, HPA045061: AB_2679203, HPA054237: AB_2682425" "unprognostic (8.71e-2)" "unprognostic (3.14e-3)" "unprognostic (7.29e-2)" "unprognostic (1.72e-1)" "unprognostic (3.80e-1)" "unprognostic (2.45e-1)" "unprognostic (6.44e-3)" "unprognostic (8.63e-2)" "unprognostic (1.40e-1)" "prognostic unfavorable (8.63e-5)" "unprognostic (8.68e-2)" "unprognostic (4.11e-2)" "prognostic favorable (2.86e-5)" "unprognostic (3.12e-3)" "unprognostic (1.51e-1)" "unprognostic (1.56e-2)" "unprognostic (2.01e-1)" 34.2 9.0 40.3 8.0 41.0 10.5 27.8 35.0 35.2 18.1 8.6 16.6 6.1 26.0 7.1 20.1 18.7 18.2 61.8 37.8 42.1 13.6 6.6 45.1 7.5 48.3 41.7 29.2 19.4 49.6 27.2 17.9 42.0 14.9 10.3 28.9 14.7 14.2 24.1 16.4 16.5 22.7 35.3 26.0 21.4 7.7 47.3 5.9 36.3 30.5 7.3 24.5 14.9 49.3 9.1 0.0 17.9 26.0 214.5 156.1 0.4 19.3 37.4 10.6 14.6 0.0 5.8 1.1 6.2 68.2 8.4 8.2 9.4 41.8 9.4 4.2 2.3 0.1 40.2 0.4 158.5 0.6 7.2 141.4 29.4 56.6 173.0 316.2 58.0 19.2 0.2 0.2 43.6 1.9 0.8 2.1 4.5 9.1 10.5 3.0 9.2 27.3 11.1 10.1 9.8 68.8 6.7 17.9 24.8 4.4 0.5 14.3 21.7 37.3 3.7 103.8 5.6 5.2 8.4 2.6 24.8 1.2 36.0 0.2 0.6 22.4 0.6 0.8 0.3 0.3 0.6 0.3 0.8 0.5 0.7 0.3 0.5 4.4 2.2 4.7 0.5 0.4 40.3 41.0 35.0 35.2 37.8 42.1 48.3 41.7 42.0 35.3 47.3 49.3 60.9 22.4 46.2 399.6 2.7 4.7 5.4 4.6 3.4 37.1 7.1 5.0 60.0 15.7 11.6 36.8 8.4 0.2 8.0 1.9 11.7 15.2 14.8 20.6 4.6 58.2 5.4 0.0 204.1 24.0 0.3 16.3 16.8 20.3 2.5 10.5 45.3 11.9 7.2 287.7 552.3 5.3 2.0 6.0 6.7 69.3 5.3 8.0 19.6 144.3 3.5 10.1 1.0 244.8 97.7 26.8 1.7 4.5 2.4 9.9 0.3 7.0 9.4 17.1 13.1 10.0 14.5 3.5 2.3 1.2 3.4 0.3 2.0 9.5 1.4 6.6 RPS6KA3 "CLS, HU-3, MRX19, RSK2" ENSG00000177189 "Ribosomal protein S6 kinase A3" P51812 X 20149911-20267519 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Cell cycle, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "Hep G2: 236.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003221, CAB003853, CAB013520" Approved Supported Nucleoplasm,Nucleoli,Cytosol No No "Cluster 46: Basophils - DNA binding" "Cluster 8: Non-specific - Mitochondria" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "Nucleoli, Cytosol" "CAB003853: AB_562343, CAB013520: AB_2533378, HPA003221: AB_1853553" "unprognostic (1.87e-2)" "unprognostic (1.03e-1)" "unprognostic (1.80e-2)" "unprognostic (4.26e-2)" "unprognostic (3.53e-1)" "unprognostic (1.11e-1)" "unprognostic (1.15e-2)" "unprognostic (1.61e-3)" "unprognostic (1.02e-1)" "unprognostic (1.57e-1)" "unprognostic (5.04e-1)" "unprognostic (1.07e-1)" "unprognostic (1.04e-1)" "unprognostic (4.49e-3)" "unprognostic (3.91e-1)" "unprognostic (1.09e-1)" "unprognostic (2.22e-1)" 21.1 18.8 6.9 33.7 10.2 16.2 14.8 12.7 12.8 16.1 8.5 32.8 24.1 17.5 8.5 18.7 15.1 26.9 21.1 8.7 9.4 19.5 45.0 32.3 31.3 8.4 10.0 10.6 17.2 59.4 5.9 19.5 8.5 19.9 31.8 15.7 13.2 18.0 51.8 15.0 27.6 27.8 8.7 29.2 21.1 5.5 10.6 32.9 21.2 40.3 32.6 34.2 8.5 8.0 44.9 77.0 28.4 14.8 27.1 47.3 8.6 38.0 57.4 27.8 37.7 87.7 56.2 29.3 12.8 40.0 40.5 30.9 32.8 32.2 51.1 24.8 26.1 34.6 46.2 236.8 27.7 67.8 34.2 30.3 25.1 43.5 54.4 24.3 101.9 30.4 23.1 81.0 29.4 21.2 44.2 20.7 20.6 57.8 45.9 23.3 60.0 33.8 23.9 36.9 13.1 12.8 51.1 15.3 54.4 35.3 0.1 20.0 57.3 30.1 20.8 96.3 21.7 64.3 42.1 32.1 56.9 33.1 72.6 11.9 3.8 7.9 4.7 5.3 8.3 2.4 5.4 5.2 5.6 3.2 3.7 4.5 5.8 6.6 6.0 6.7 2.9 2.2 6.9 10.2 12.7 12.8 8.7 9.4 8.4 10.0 8.5 8.7 10.6 8.0 60.6 44.8 67.5 31.6 34.8 54.4 37.0 21.2 10.2 37.8 20.4 10.8 22.9 34.3 41.1 16.5 22.9 4.0 70.0 63.5 3.9 26.3 0.4 10.8 24.0 61.1 25.0 19.1 142.2 30.5 6.7 31.6 24.5 26.1 44.3 8.3 34.6 65.4 22.6 13.5 108.4 59.1 28.5 40.8 104.3 1.5 13.1 62.6 37.4 126.5 53.7 27.5 46.4 116.6 27.0 37.4 57.9 21.1 25.5 56.6 33.5 25.1 23.3 9.7 19.7 41.5 21.3 6.4 8.7 13.8 55.5 3.6 66.0 14.2 61.1 63.8 RPS6KA4 "MSK2, RSK-B" ENSG00000162302 "Ribosomal protein S6 kinase A4" O75676 11 64359148-64372215 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Inflammatory response, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 70.0;dendritic cells: 75.0;Pancreatic endocrine cells: 65.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "plasmacytoid DC: 10.5" "Group enriched" "Detected in many" 5 "dendritic cells: 10.5;monocytes: 2.7" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB008649, HPA023225" Approved Supported Nucleoplasm,Cytosol No No "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 18: U-2197 - ECM organization" "Cluster 47: Cytotrophoblasts - Unknown function" Nucleoplasm Cytosol "CAB008649: AB_1619460, HPA023225: AB_1854144" "unprognostic (2.30e-1)" "unprognostic (7.05e-2)" "unprognostic (2.03e-1)" "unprognostic (4.07e-2)" "unprognostic (2.40e-1)" "unprognostic (7.47e-2)" "prognostic unfavorable (8.17e-4)" "prognostic unfavorable (9.27e-4)" "unprognostic (2.45e-1)" "unprognostic (9.03e-2)" "unprognostic (1.41e-2)" "unprognostic (3.06e-3)" "unprognostic (1.98e-2)" "unprognostic (3.93e-3)" "unprognostic (5.25e-2)" "unprognostic (1.09e-1)" "unprognostic (2.85e-1)" 15.0 13.1 14.8 11.8 16.1 10.9 12.5 17.0 17.9 13.7 10.5 16.8 9.8 16.5 2.8 31.0 12.0 4.7 16.2 15.3 13.7 14.2 12.0 16.4 12.0 14.7 14.7 8.5 12.2 3.3 6.8 11.7 14.7 13.1 5.6 2.1 12.5 5.6 16.0 22.8 17.1 6.8 14.4 25.0 15.8 3.5 15.1 5.7 10.2 5.0 9.5 16.6 14.6 14.3 76.1 41.5 5.9 15.0 12.8 11.9 84.0 39.4 20.6 30.2 14.9 41.7 38.8 7.9 44.9 22.9 38.6 69.1 7.1 32.1 14.7 24.1 14.0 17.8 36.8 21.6 12.8 18.0 32.0 12.0 29.7 25.7 20.9 10.9 18.4 14.2 7.4 10.6 15.6 69.2 16.6 28.4 6.5 29.2 88.1 31.8 24.4 25.3 21.1 34.4 8.7 6.9 40.7 24.8 35.6 8.5 28.6 22.3 37.0 41.0 51.7 74.7 35.9 12.5 10.4 7.8 27.0 20.6 21.2 1.3 2.7 1.4 0.7 2.1 0.7 0.4 0.5 0.6 2.2 0.2 0.3 0.3 0.2 0.2 1.3 10.5 0.5 2.6 14.8 16.1 17.0 17.9 15.3 13.7 14.7 14.7 14.7 14.4 15.1 14.3 11.8 3.2 3.0 8.5 6.4 12.1 6.8 8.6 8.6 7.3 5.4 4.8 15.2 7.2 5.4 3.7 4.2 70.0 75.0 25.2 5.9 20.1 0.8 3.5 8.7 9.9 8.4 9.9 6.6 25.2 38.2 9.3 26.0 7.6 19.1 5.7 10.8 7.8 29.6 8.4 5.3 14.3 2.0 30.5 13.2 1.5 11.1 25.8 8.8 11.2 26.6 3.6 10.3 4.5 5.4 65.1 12.8 6.8 5.7 10.2 16.2 8.4 3.1 2.1 0.0 6.0 10.2 0.7 6.5 13.9 10.7 46.7 11.3 7.5 19.9 9.6 RPS6KA5 "MSK1, RLPK" ENSG00000100784 "Ribosomal protein S6 kinase A5" O75582 14 90847861-91060641 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Inflammatory response, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Glandular and luminal cells: 162.0;Oligodendrocytes: 156.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HMC-1: 31.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA001274, HPA001780, CAB025458" Approved Enhanced Nucleoplasm NA NA "Cluster 38: Basophils - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 3: HMC-1 - Innate immune response" "Cluster 44: Endometrium - Transcription" Nucleoplasm "CAB025458: , HPA001274: AB_1079417, HPA001780: AB_2666432" "unprognostic (3.05e-2)" "unprognostic (2.19e-3)" "unprognostic (4.27e-4)" "unprognostic (1.98e-3)" "unprognostic (4.79e-2)" "unprognostic (4.20e-4)" "unprognostic (3.70e-2)" "unprognostic (5.80e-4)" "unprognostic (6.70e-2)" "unprognostic (8.39e-2)" "unprognostic (1.84e-1)" "unprognostic (1.97e-1)" "unprognostic (1.38e-4)" "unprognostic (5.73e-3)" "unprognostic (1.07e-1)" "unprognostic (2.42e-1)" "unprognostic (1.75e-1)" 2.6 0.9 2.4 2.9 7.8 3.3 7.5 14.7 3.7 3.1 1.0 6.6 3.7 4.9 0.3 5.3 4.1 2.8 2.6 1.6 3.0 1.9 1.7 2.8 3.4 4.1 3.8 4.6 1.5 3.0 2.6 3.4 4.1 3.1 5.1 3.0 4.9 4.3 9.0 3.7 4.9 3.9 2.9 3.1 5.4 2.4 4.5 5.0 4.0 9.9 3.5 5.4 4.1 8.0 1.3 2.1 2.7 1.4 0.0 0.5 9.4 0.9 1.3 2.9 4.1 1.2 2.7 6.7 2.8 2.8 1.8 4.7 2.2 1.8 5.1 1.0 3.5 7.5 1.8 0.4 0.0 7.1 31.8 0.8 4.3 1.7 1.3 0.7 3.2 5.1 0.7 7.1 2.9 3.1 2.0 2.2 0.9 4.6 3.4 3.3 11.2 3.2 3.2 2.9 10.4 3.2 2.7 14.8 8.1 1.8 3.0 1.9 0.6 0.8 1.5 0.6 3.4 2.8 3.5 5.9 1.7 5.0 10.6 16.9 3.0 9.0 3.7 2.5 6.1 4.5 4.6 3.5 2.7 5.8 5.5 3.0 19.8 10.4 3.5 1.2 7.9 2.6 2.4 7.8 14.7 3.7 1.6 3.0 4.1 3.8 4.1 2.9 4.5 8.0 13.2 19.2 26.5 80.3 53.7 40.4 45.2 20.4 53.5 32.9 41.4 42.9 20.7 14.3 22.7 7.3 16.7 43.7 21.0 36.7 0.0 11.1 9.1 96.2 19.0 21.4 16.3 22.5 65.4 5.1 6.5 21.8 13.3 162.0 92.2 32.5 20.3 6.5 7.1 26.9 32.5 17.3 4.1 17.6 13.4 3.1 14.0 21.8 19.6 53.4 21.2 10.5 23.7 36.7 156.1 3.5 13.0 11.7 26.0 29.3 41.9 3.7 31.3 32.1 13.1 51.9 22.3 21.2 23.7 35.5 46.3 111.8 48.6 7.2 20.8 52.7 RPS6KA6 RSK4 ENSG00000072133 "Ribosomal protein S6 kinase A6" Q9UK32 X 84058346-84188199 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 75.3;Inhibitory neurons: 70.7;Oligodendrocyte precursor cells: 31.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "NTERA-2: 8.1;PC-3: 7.9;RH-30: 9.9;SH-SY5Y: 9.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA002852, HPA003904" Uncertain Supported Nucleoplasm,Nucleoli,Mitochondria NA NA "Cluster 35: T-regs - Unknown function" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 5: NTERA-2 - Transcription" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Mitochondria" Nucleoli "HPA002852: AB_1079854, HPA003904: AB_1079853" "unprognostic (1.17e-1)" "unprognostic (1.02e-2)" "unprognostic (3.44e-1)" "unprognostic (4.93e-4)" "unprognostic (1.71e-1)" "unprognostic (3.04e-3)" "unprognostic (2.09e-2)" "unprognostic (2.50e-1)" "unprognostic (2.86e-1)" "unprognostic (4.88e-2)" "unprognostic (3.38e-3)" "unprognostic (2.88e-1)" "unprognostic (2.12e-9)" "unprognostic (4.44e-3)" "unprognostic (1.30e-2)" "unprognostic (2.34e-2)" "unprognostic (8.49e-3)" 0.4 2.0 2.6 0.5 3.1 0.1 1.7 3.2 3.0 2.0 2.6 2.9 1.2 1.7 3.1 0.8 2.2 1.1 0.6 2.7 3.4 5.7 0.6 0.6 0.2 2.7 2.4 2.6 0.9 7.0 5.8 0.3 2.2 2.8 2.3 7.0 1.7 2.7 1.6 2.0 1.3 1.0 1.5 0.4 1.7 1.5 2.4 1.0 8.1 0.4 0.3 1.3 1.4 2.0 0.0 2.4 2.6 0.0 2.4 2.2 0.0 5.2 2.7 2.3 1.9 1.9 2.0 0.0 0.0 2.6 0.0 0.1 6.4 4.6 5.1 0.0 3.5 0.0 0.1 0.0 2.7 0.0 0.0 1.4 0.0 0.0 2.4 3.0 0.6 0.0 0.0 0.1 2.0 0.0 1.1 0.1 8.1 0.0 7.9 0.0 9.9 0.0 0.5 5.4 0.0 9.4 0.0 3.4 0.0 3.8 1.4 0.0 0.0 0.1 2.4 0.0 0.0 0.3 0.0 0.0 0.8 0.0 0.0 0.6 0.0 0.1 0.1 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.6 0.0 2.6 3.1 3.2 3.0 2.7 3.4 2.7 2.4 2.2 1.5 2.4 2.0 0.3 9.6 2.7 6.2 0.7 0.3 5.3 0.3 3.4 21.1 3.6 3.4 2.6 12.8 1.9 18.4 25.0 2.6 0.1 6.7 1.9 0.5 0.7 1.9 1.2 1.2 25.0 2.7 75.3 1.2 0.7 2.2 2.0 0.9 0.0 21.8 1.1 1.3 0.2 1.7 70.7 3.6 0.0 0.0 0.0 0.4 4.4 0.5 0.0 3.7 0.1 2.1 1.0 31.2 5.8 1.3 3.4 6.0 0.0 9.2 1.8 4.3 3.7 18.2 0.0 4.9 1.5 8.4 6.2 2.5 0.4 2.3 0.9 2.0 6.5 5.2 RPS6KB1 "p70(S6K)-alpha, PS6K, S6K, S6K1, STK14A" ENSG00000108443 "Ribosomal protein S6 kinase B1" P23443 17 59893046-59950574 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Cell cycle, Translation regulation" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in all" 5 "MCF7: 243.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003838, CAB018346, HPA039442" Approved Supported Nucleoplasm NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 52: Non-specific - Ribosome" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 59: Non-specific - Transcription" Nucleoplasm "CAB003838: AB_562325, CAB018346: AB_632156, HPA039442: AB_2676510" "unprognostic (2.25e-1)" "unprognostic (4.52e-2)" "unprognostic (1.91e-3)" "unprognostic (1.35e-2)" "unprognostic (9.81e-2)" "unprognostic (1.13e-1)" "unprognostic (3.72e-3)" "unprognostic (1.70e-1)" "unprognostic (5.86e-2)" "unprognostic (1.66e-1)" "unprognostic (3.67e-1)" "unprognostic (1.76e-2)" "prognostic unfavorable (5.09e-7)" "unprognostic (3.45e-1)" "unprognostic (2.09e-1)" "unprognostic (3.98e-2)" "unprognostic (1.52e-3)" 14.0 11.3 7.1 11.9 7.8 18.0 13.3 11.8 9.8 11.8 9.4 10.7 10.0 13.8 10.1 16.3 10.2 9.4 10.6 7.2 6.6 9.8 15.2 9.9 14.2 7.3 7.0 14.9 16.9 14.9 7.4 15.4 7.5 10.6 11.0 10.9 9.4 10.2 22.7 10.6 9.3 14.3 6.2 12.4 11.1 6.9 7.5 15.2 11.9 18.3 17.3 14.9 11.0 9.6 34.5 33.5 27.5 26.2 18.1 26.2 20.8 31.2 28.3 26.3 29.3 27.6 16.8 41.7 37.9 25.4 32.1 17.3 36.0 27.3 42.7 23.3 41.5 28.7 21.2 31.2 26.9 44.5 27.1 26.7 20.7 31.0 22.8 21.9 35.0 26.0 38.5 25.9 19.7 243.6 53.2 18.4 18.6 29.8 24.9 30.8 46.7 38.8 21.9 25.1 20.1 23.8 26.2 15.2 16.6 31.7 29.7 24.2 31.1 25.8 42.9 21.2 42.0 46.2 42.0 46.3 19.4 26.7 21.2 43.8 12.1 11.4 12.7 12.2 15.5 10.4 11.6 14.7 15.3 9.4 13.5 14.3 11.5 11.9 14.4 9.5 11.9 10.3 7.1 7.8 11.8 9.8 7.2 6.6 7.3 7.0 7.5 6.2 7.5 9.6 22.8 22.4 34.2 29.0 32.6 33.0 21.4 13.0 30.7 18.0 23.1 17.8 16.8 12.8 30.4 3.7 18.8 24.3 33.5 12.4 3.9 12.9 5.1 24.0 31.7 25.5 13.2 11.8 47.3 16.4 18.2 24.8 26.0 37.7 23.4 20.0 13.6 15.1 12.1 18.5 45.2 14.1 4.1 15.2 20.4 3.8 15.8 19.0 10.6 28.1 20.0 12.8 18.6 25.6 54.8 15.1 10.9 18.0 34.6 27.9 9.3 9.2 21.1 18.9 26.3 33.4 32.6 13.0 13.7 34.5 32.0 30.5 29.9 26.0 13.9 25.4 RPS6KB2 "KLS, P70-BETA, p70S6Kb, S6Kβ, S6KB, S6Kbeta, STK14B" ENSG00000175634 "Ribosomal protein S6 kinase B2" Q9UBS0 11 67428460-67435401 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA010010, CAB019404" Approved Supported Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 55: Plasma cells - Humoral immune response" Cytosol "CAB019404: AB_331355, HPA010010: AB_1856469" "unprognostic (1.38e-1)" "unprognostic (2.36e-3)" "unprognostic (8.50e-2)" "unprognostic (2.56e-2)" "unprognostic (1.84e-1)" "unprognostic (1.41e-1)" "unprognostic (9.01e-3)" "unprognostic (5.10e-2)" "unprognostic (1.22e-1)" "unprognostic (9.49e-3)" "unprognostic (7.66e-2)" "unprognostic (2.79e-2)" "prognostic unfavorable (2.03e-7)" "unprognostic (1.28e-2)" "unprognostic (1.55e-1)" "unprognostic (2.12e-1)" "unprognostic (2.66e-1)" 16.2 28.0 9.7 13.8 10.8 28.2 17.0 9.9 12.4 23.5 13.2 22.8 26.5 17.7 6.0 71.9 20.0 10.6 22.1 9.1 9.3 21.3 50.2 19.5 18.4 10.9 10.3 16.2 35.4 17.5 20.6 13.6 10.6 31.6 12.8 4.2 31.5 9.9 37.9 81.6 25.4 10.1 10.2 33.7 35.2 9.6 9.9 24.0 20.1 26.0 20.1 19.3 31.4 11.3 58.2 42.7 22.8 39.0 10.4 20.0 30.0 27.4 33.9 49.7 34.2 67.2 37.5 21.1 46.3 26.9 31.0 41.8 25.9 41.4 19.9 36.9 70.0 34.5 54.2 55.5 35.2 43.7 40.4 25.5 42.8 26.3 26.9 12.5 37.5 54.8 55.8 54.8 25.4 88.5 68.1 68.4 24.9 83.7 54.6 50.0 31.8 100.5 23.0 32.6 34.4 37.1 28.0 76.8 59.8 13.2 90.4 35.7 15.8 25.8 27.6 63.1 31.1 48.8 43.9 34.4 42.4 27.3 33.1 18.8 37.2 28.5 23.8 42.6 24.5 23.4 22.9 23.9 44.1 21.9 16.1 17.9 24.7 29.6 49.9 30.4 34.5 37.3 9.7 10.8 9.9 12.4 9.1 9.3 10.9 10.3 10.6 10.2 9.9 11.3 22.0 9.6 20.5 6.8 48.1 49.8 28.0 48.9 19.9 25.3 32.6 27.8 1.3 28.6 31.2 7.3 10.4 71.8 45.0 66.9 43.0 44.5 14.9 16.0 16.9 17.9 46.2 65.0 7.7 64.8 89.1 21.9 48.9 19.3 27.9 23.2 18.2 57.4 61.3 33.7 7.1 67.7 34.6 45.8 29.1 29.4 20.2 36.9 19.6 3.7 56.6 28.5 73.2 5.0 12.1 46.6 70.4 17.3 82.1 43.7 115.0 42.2 16.0 27.6 19.7 16.7 26.9 15.8 16.0 52.5 63.6 103.6 41.7 27.5 58.3 39.4 RPS6KC1 "humS6PKh1, RSKL1" ENSG00000136643 "Ribosomal protein S6 kinase C1" Q96S38 1 213051233-213274774 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 86.2;Excitatory neurons: 273.2;Inhibitory neurons: 151.2;Microglial cells: 101.2;Oligodendrocyte precursor cells: 116.6;Oligodendrocytes: 137.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 16.8" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026531, HPA031565" Approved Supported Endosomes,Lysosomes NA NA "Cluster 18: Basophils - Vesicular transport" "Cluster 78: Testis - Spermatogenesis" "Cluster 3: HMC-1 - Innate immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Endosomes, Lysosomes" "HPA026531: AB_10601497, HPA031565: AB_2673935" "unprognostic (3.90e-2)" "unprognostic (5.90e-2)" "unprognostic (3.22e-1)" "unprognostic (4.88e-2)" "unprognostic (2.42e-1)" "unprognostic (9.81e-2)" "unprognostic (1.32e-2)" "unprognostic (1.64e-1)" "unprognostic (4.10e-2)" "unprognostic (3.34e-1)" "unprognostic (4.18e-1)" "unprognostic (5.11e-2)" "prognostic unfavorable (2.70e-4)" "unprognostic (8.10e-2)" "unprognostic (5.48e-2)" "unprognostic (2.98e-2)" "unprognostic (4.44e-2)" 8.3 8.8 9.7 7.1 11.5 4.9 7.2 8.2 13.9 8.8 4.3 7.8 6.2 9.4 5.2 6.7 7.6 7.7 6.4 12.9 8.8 6.4 7.4 7.1 5.2 8.6 8.8 9.2 9.2 10.2 4.5 8.4 8.6 11.5 6.5 9.3 6.8 11.3 10.0 4.3 6.0 12.6 8.6 7.9 8.6 19.3 9.9 5.4 6.9 11.6 5.4 8.1 4.6 13.2 11.0 9.3 15.0 16.3 15.0 21.6 13.2 14.1 20.7 21.5 24.6 7.7 11.9 6.9 9.3 21.4 14.1 8.9 18.3 11.6 16.2 14.7 6.7 18.7 10.9 10.5 13.6 11.9 21.4 14.3 9.8 18.8 10.2 17.9 18.2 6.7 24.6 10.5 22.3 6.3 5.0 3.9 21.8 9.8 10.4 5.9 14.1 6.8 9.7 10.9 8.7 22.6 15.3 11.9 20.6 25.5 17.1 4.9 17.0 14.6 13.3 16.9 9.3 6.1 12.6 5.2 6.2 4.5 15.2 16.8 4.5 3.5 2.5 6.4 2.1 2.4 2.0 2.2 8.5 1.6 1.3 3.0 0.5 3.8 6.7 1.0 1.6 2.2 9.7 11.5 8.2 13.9 12.9 8.8 8.6 8.8 8.6 8.6 9.9 13.2 10.1 9.6 5.8 86.2 8.8 2.9 2.7 4.5 7.4 17.4 6.6 5.6 9.6 7.2 4.3 0.0 14.6 3.5 7.7 4.8 0.0 5.2 33.6 7.4 12.1 9.9 3.6 12.4 273.2 8.0 4.0 10.1 15.3 9.9 7.6 16.6 7.9 9.3 7.1 20.2 151.2 3.3 6.1 11.4 7.7 45.2 11.1 15.1 7.2 101.2 13.1 5.6 10.3 116.6 137.6 6.6 2.1 7.5 8.1 5.4 4.4 5.7 4.7 20.0 13.1 13.7 9.1 19.6 19.6 9.1 4.4 3.8 10.4 6.1 4.3 3.2 RPS6KL1 "MGC11287, RSKL2" ENSG00000198208 "Ribosomal protein S6 kinase like 1" Q9Y6S9 14 74903951-74923302 "Enzymes, Predicted intracellular proteins" "Kinase, Ribonucleoprotein, Ribosomal protein, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 29.4" "Cell type enhanced" "Detected in many" "Bipolar cells: 72.3;Cone photoreceptor cells: 83.4;Horizontal cells: 40.4;Rod photoreceptor cells: 73.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "plasmacytoid DC: 2.3" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "HMC-1: 17.5;SCLC-21H: 25.1;SK-BR-3: 19.7;U-266/70: 13.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027451, HPA027794" Approved Approved Nucleoplasm NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 54: Non-specific - Microtubule organization" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 9: Photoreceptor cells - Phototransduction" Nucleoplasm "HPA027451: AB_10599304, HPA027794: AB_10602098" "unprognostic (2.71e-2)" "unprognostic (9.33e-3)" "unprognostic (3.36e-1)" "unprognostic (1.13e-2)" "unprognostic (1.08e-1)" "unprognostic (1.63e-2)" "unprognostic (1.44e-2)" "unprognostic (7.49e-4)" "unprognostic (2.06e-1)" "unprognostic (1.54e-1)" "unprognostic (4.09e-3)" "unprognostic (2.91e-1)" "unprognostic (1.11e-1)" "unprognostic (1.33e-2)" "unprognostic (1.14e-1)" "unprognostic (7.03e-2)" "unprognostic (7.52e-2)" 3.7 4.5 22.4 1.1 23.1 3.0 4.1 21.6 29.4 1.9 17.6 6.7 2.2 4.1 4.8 2.9 2.5 1.8 13.7 23.4 21.2 4.8 4.2 2.5 1.4 20.8 21.3 0.9 7.9 1.3 18.8 0.5 20.5 3.8 3.2 20.6 3.1 3.0 19.1 2.3 3.1 4.0 19.3 3.2 2.5 13.9 21.7 0.6 4.3 4.2 1.1 3.4 1.7 22.9 3.3 0.5 1.3 4.4 0.2 0.0 6.3 0.7 0.2 1.6 0.4 5.8 2.4 0.1 4.5 1.1 0.7 0.4 1.9 0.1 1.6 0.0 0.6 2.7 1.2 4.8 5.7 3.2 17.5 0.5 3.5 2.3 0.0 0.0 7.9 0.0 3.2 0.9 0.1 10.7 0.1 1.1 1.3 1.0 5.1 2.0 0.1 9.7 2.3 0.0 25.1 3.8 0.4 19.7 3.4 2.7 1.5 2.1 5.8 0.1 0.2 4.0 0.0 13.8 8.1 6.9 1.8 0.3 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.7 0.1 0.0 0.0 0.3 0.7 0.8 0.0 0.0 0.0 2.3 0.0 0.1 22.4 23.1 21.6 29.4 23.4 21.2 20.8 21.3 20.5 19.3 21.7 22.9 2.6 0.0 0.0 10.4 0.9 0.8 2.7 1.2 0.6 72.3 4.3 3.9 6.1 0.0 0.8 3.7 83.4 1.7 2.0 2.4 1.9 1.3 7.7 0.8 0.6 2.6 6.7 5.2 24.5 6.2 1.7 1.0 0.5 0.7 0.0 0.7 1.1 2.6 3.7 40.4 19.7 2.1 4.1 0.3 1.3 7.4 2.1 1.0 3.6 3.7 0.0 5.0 3.1 15.6 15.1 3.8 1.6 2.6 0.5 2.1 1.5 1.9 4.5 73.6 6.6 3.8 3.1 27.0 22.9 1.2 1.3 1.4 1.0 1.5 3.1 1.6 RYK "D3S3195, JTK5, JTK5A, RYK1" ENSG00000163785 "Receptor like tyrosine kinase" P34925 3 134065303-134250859 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Wnt signaling pathway" "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Granulosa cells: 121.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB034117, HPA045503, HPA075430" Uncertain Approved "Golgi apparatus,Cytosol" NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 89: Fibroblasts - ECM organization" "Cluster 30: Epithelial cell lines - Translation" "Cluster 40: Granulosa cells - Unknown function" "Golgi apparatus" Cytosol "CAB034117: AB_2183048, HPA045503: AB_2679353, HPA075430: AB_2732293" "unprognostic (7.84e-2)" "unprognostic (5.82e-2)" "unprognostic (2.22e-2)" "unprognostic (2.34e-2)" "unprognostic (2.21e-1)" "unprognostic (1.09e-1)" "prognostic unfavorable (2.60e-4)" "unprognostic (2.60e-2)" "unprognostic (6.59e-2)" "unprognostic (1.62e-1)" "unprognostic (1.07e-3)" "unprognostic (9.66e-2)" "unprognostic (2.42e-2)" "unprognostic (5.54e-2)" "unprognostic (3.13e-1)" "unprognostic (3.43e-1)" "unprognostic (2.85e-2)" 31.8 25.2 15.7 15.7 16.2 17.1 42.8 15.4 19.8 40.2 19.9 34.5 20.1 46.1 40.0 29.6 33.4 24.3 30.3 14.5 15.3 25.4 22.3 25.3 18.9 15.9 15.6 82.1 24.5 29.7 17.0 36.6 15.5 36.3 26.2 15.9 26.9 43.9 25.3 34.7 21.4 40.6 16.3 22.9 23.2 47.0 16.5 21.2 40.9 32.2 20.5 34.7 32.6 16.4 78.8 20.6 63.3 48.7 79.8 84.4 48.8 51.0 117.7 66.4 74.2 65.6 58.8 15.3 82.4 63.1 63.7 71.6 45.5 64.3 94.5 25.9 20.5 40.6 22.4 42.4 62.2 20.0 34.4 56.1 74.0 41.2 82.2 72.5 56.5 26.4 14.5 7.5 66.0 37.6 28.0 25.9 53.4 65.2 24.3 13.7 48.4 32.4 54.5 57.3 31.0 45.6 61.7 44.5 79.1 40.5 55.7 35.8 42.1 54.8 49.6 57.8 41.8 3.1 4.2 8.3 34.8 33.1 39.6 4.6 0.8 1.6 1.1 0.8 1.3 0.6 2.0 1.3 0.3 1.2 1.9 1.5 0.3 1.6 0.8 0.0 0.5 0.5 15.7 16.2 15.4 19.8 14.5 15.3 15.9 15.6 15.5 16.3 16.5 16.4 62.5 12.8 27.9 31.6 20.6 41.3 36.6 26.3 39.3 23.1 45.4 37.2 34.9 18.6 23.7 44.1 29.2 19.4 23.1 15.9 0.0 15.9 16.2 27.6 41.7 31.0 13.9 13.2 69.5 21.1 14.7 41.3 15.8 32.7 17.7 121.2 40.7 24.1 11.3 13.5 59.7 20.9 12.2 18.6 21.6 7.4 33.2 16.1 14.2 65.6 12.8 26.8 13.4 65.9 57.9 21.7 19.7 32.7 12.9 42.8 15.4 10.5 13.9 39.8 46.0 33.8 38.1 24.6 40.9 33.7 38.1 10.8 18.4 50.8 22.2 38.9 SAT1 "SAT, SSAT" ENSG00000130066 "Spermidine/spermine N1-acetyltransferase 1" P21673 X 23783173-23786226 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Basal respiratory cells: 8151.3;Langerhans cells: 13855.3;Prostatic glandular cells: 7419.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 3422.0;non-classical monocyte: 2519.0" "Group enriched" "Detected in all" 9 "granulocytes: 3422.0;monocytes: 2519.0" "Cell line enhanced" "Detected in all" "HBEC3-KT: 551.5;hTERT-HME1: 821.9;RPTEC TERT1: 694.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB047343, HPA055312, CAB069914" Supported NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 30: Epithelial cell lines - Translation" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "CAB047343: , CAB069914: AB_830224, HPA055312: AB_2682781" "unprognostic (4.19e-2)" "unprognostic (3.92e-2)" "unprognostic (6.41e-2)" "prognostic favorable (2.87e-4)" "unprognostic (8.58e-2)" "unprognostic (7.90e-3)" "unprognostic (8.52e-3)" "unprognostic (2.22e-2)" "unprognostic (2.81e-1)" "unprognostic (1.18e-1)" "unprognostic (8.38e-3)" "unprognostic (2.23e-1)" "unprognostic (7.58e-2)" "unprognostic (5.13e-2)" "unprognostic (1.61e-1)" "unprognostic (9.97e-3)" "unprognostic (1.65e-1)" 843.8 307.2 171.6 568.4 175.0 1484.9 454.0 167.0 279.5 337.8 219.7 339.0 630.9 319.0 170.8 407.4 322.7 600.8 604.4 171.8 202.0 739.5 885.0 1252.9 431.3 186.2 178.6 197.9 229.3 268.7 548.5 603.5 188.6 413.1 364.3 108.3 786.6 342.2 66.2 200.1 509.5 175.4 185.5 706.6 562.6 116.2 197.7 231.8 757.0 79.0 333.4 536.2 241.6 206.6 62.2 123.1 30.8 48.3 256.0 103.8 83.6 89.2 149.8 21.7 50.2 59.0 179.3 102.7 160.0 21.1 172.4 91.9 16.4 551.5 78.8 34.1 74.3 49.9 60.0 503.5 327.5 48.8 46.1 216.2 412.0 169.0 821.9 197.2 181.5 16.4 21.4 88.4 63.8 59.1 35.9 219.1 20.6 455.2 56.3 30.0 19.8 126.1 694.6 126.0 8.7 8.9 91.2 204.8 179.2 222.3 31.5 10.7 68.9 175.6 8.9 106.6 44.7 37.1 9.6 23.1 104.8 28.8 34.2 557.6 720.4 478.9 66.0 1930.3 41.6 125.3 77.4 53.8 324.8 79.1 45.9 53.3 3422.0 33.8 2519.0 161.2 231.5 742.5 171.6 175.0 167.0 279.5 171.8 202.0 186.2 178.6 188.6 185.5 197.7 206.6 798.0 734.0 1585.4 98.9 875.4 2435.0 3753.4 8151.3 1203.6 54.9 895.9 574.4 454.2 574.7 5509.5 829.4 116.7 853.1 409.5 1249.8 1189.5 5869.5 17.3 3940.5 859.6 1554.6 526.9 195.2 40.3 3065.2 1643.7 1211.3 1347.1 5651.2 870.6 110.6 558.3 994.1 2115.2 72.3 77.6 852.3 3733.2 4693.0 13855.3 55.2 165.3 5207.7 3922.0 213.6 5274.6 501.9 189.5 90.5 14.2 2774.1 1293.8 92.2 1091.8 7419.8 1851.7 2065.2 4274.2 114.4 151.2 765.7 857.5 31.6 14.7 1022.4 1468.3 2880.9 899.3 260.2 804.4 6549.5 SAT2 SSAT2 ENSG00000141504 "Spermidine/spermine N1-acetyltransferase family member 2" Q96F10 17 7626234-7627876 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 139.8" "Cell type enhanced" "Detected in all" "Proximal enterocytes: 1060.0;Proximal tubular cells: 1313.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA022136, HPA057096" Enhanced NA NA 11000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 18: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA022136: AB_1856592, HPA057096: AB_2683334" "unprognostic (2.61e-2)" "unprognostic (1.27e-2)" "unprognostic (3.23e-2)" "prognostic favorable (8.76e-6)" "unprognostic (2.18e-2)" "unprognostic (2.32e-1)" "unprognostic (7.20e-2)" "prognostic favorable (6.71e-4)" "unprognostic (4.14e-2)" "unprognostic (2.75e-1)" "prognostic favorable (6.05e-5)" "unprognostic (1.83e-1)" "unprognostic (6.66e-3)" "unprognostic (2.49e-1)" "unprognostic (1.86e-1)" "unprognostic (1.50e-1)" "unprognostic (3.12e-2)" 28.3 102.8 27.7 9.6 28.4 11.3 26.8 28.7 37.5 26.2 32.9 30.5 92.7 25.2 25.1 17.2 26.1 15.8 33.5 27.9 29.2 97.6 139.8 19.0 9.5 28.4 28.5 44.5 47.4 36.0 30.4 8.6 28.3 27.4 15.4 21.1 27.0 16.4 31.8 19.0 65.5 17.1 28.9 29.1 33.4 17.1 29.2 8.0 28.2 20.5 11.8 22.6 19.8 28.8 17.9 27.3 24.1 44.9 37.5 43.6 3.0 12.2 44.3 27.2 33.8 9.3 8.9 3.3 6.8 11.9 30.4 15.3 15.4 11.1 18.0 5.1 41.9 3.6 15.8 49.2 45.3 0.1 12.3 54.6 28.3 16.2 11.9 36.6 39.9 3.5 2.5 5.3 28.8 1.6 0.3 4.1 9.9 10.2 16.6 6.6 11.8 4.2 42.8 20.6 2.6 22.4 11.4 23.4 26.3 21.4 15.5 3.3 17.3 13.2 8.5 0.3 19.3 9.9 9.6 0.7 44.5 5.2 19.7 7.6 41.9 9.5 14.2 28.3 16.7 13.6 12.0 14.6 30.7 12.7 17.8 12.7 2.7 12.4 14.9 14.0 19.5 22.5 27.7 28.4 28.7 37.5 27.9 29.2 28.4 28.5 28.3 28.9 29.2 28.8 70.3 44.8 121.2 76.4 76.2 82.6 90.6 83.2 134.3 121.9 124.1 140.8 62.8 257.4 82.6 80.9 68.8 70.8 68.7 80.4 422.6 135.9 19.4 66.9 79.0 69.8 132.7 25.9 86.2 66.2 33.7 97.3 43.3 59.2 62.1 181.4 114.5 289.0 165.3 129.5 64.6 116.4 124.1 142.7 165.1 28.0 181.7 110.7 94.3 25.3 103.4 156.9 49.4 32.6 36.9 92.8 129.1 119.2 92.9 108.6 1060.0 1313.7 83.9 148.6 72.3 91.2 92.2 30.4 7.8 79.6 56.1 79.2 67.0 321.2 116.8 103.9 SBK1 Sbk ENSG00000188322 "SH3 domain binding kinase 1" Q52WX2 16 28259246-28323849 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 26.8;skeletal muscle: 44.1" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 81.3;Excitatory neurons: 38.2;Granulosa cells: 26.3;NK-cells: 36.0" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "AF22: 28.8;AN3-CA: 20.9;NTERA-2: 29.6;REH: 32.6;SCLC-21H: 45.5;SH-SY5Y: 42.6" "Region enriched" "Detected in all" 5 "cerebellum: 275.9" "Low region specificity" "Detected in all" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 80: Striated muscle - Unknown function" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 40: Granulosa cells - Unknown function" "unprognostic (5.15e-2)" "prognostic favorable (6.88e-4)" "unprognostic (2.08e-1)" "unprognostic (6.22e-2)" "unprognostic (1.81e-1)" "unprognostic (1.71e-2)" "unprognostic (5.71e-3)" "unprognostic (3.66e-3)" "unprognostic (1.17e-1)" "unprognostic (1.62e-2)" "unprognostic (2.87e-2)" "unprognostic (6.38e-2)" "unprognostic (1.19e-3)" "unprognostic (3.99e-2)" "unprognostic (3.50e-2)" "unprognostic (7.91e-2)" "unprognostic (5.03e-3)" 0.1 2.4 8.0 0.9 7.0 1.3 0.8 26.8 15.0 0.7 0.0 0.3 0.3 0.9 0.4 0.6 0.7 0.2 2.1 11.6 6.7 1.8 0.2 0.8 1.7 6.6 7.6 0.5 1.9 2.9 5.6 0.0 6.7 1.5 0.3 5.0 2.7 0.2 44.1 1.1 0.6 0.1 3.2 1.9 0.8 2.5 12.8 10.0 2.5 9.1 0.8 0.3 0.3 7.9 0.3 0.4 28.8 20.9 0.0 0.0 4.5 0.0 0.0 0.1 0.0 0.2 1.4 0.7 0.2 0.0 0.4 0.5 8.8 0.2 0.1 3.0 1.2 0.1 0.3 0.9 0.0 0.1 0.5 0.0 0.3 0.0 0.0 0.2 0.2 11.2 0.0 1.8 0.0 3.6 14.0 0.3 29.6 1.9 0.2 32.6 1.6 0.6 0.1 1.8 45.5 42.6 0.8 2.7 0.4 3.5 3.3 0.1 0.8 0.1 4.3 0.4 0.2 0.3 0.0 0.5 0.1 0.5 1.6 0.3 0.0 0.0 1.5 0.0 0.5 0.0 0.4 0.8 0.0 0.1 0.4 1.0 0.0 0.7 0.0 0.0 0.5 0.1 8.0 7.0 26.8 15.0 11.6 6.7 6.6 7.6 6.7 3.2 12.8 7.9 0.2 3.2 0.5 1.0 0.6 0.6 0.7 1.4 3.4 13.0 6.3 2.9 3.6 2.8 2.5 0.0 81.3 0.0 11.1 0.1 1.9 8.2 1.2 2.4 0.3 0.3 6.0 0.4 38.2 5.6 0.0 0.4 0.0 1.8 0.0 26.3 0.0 0.2 0.1 0.0 13.8 0.8 4.1 0.0 0.8 3.9 0.6 0.4 0.0 0.0 0.7 4.1 36.0 5.0 1.7 3.6 0.0 0.0 2.3 1.5 0.1 0.7 1.7 2.7 0.0 2.5 2.7 2.4 2.1 1.0 0.1 0.1 5.6 0.2 1.2 0.4 SBK2 SGK069 ENSG00000187550 "SH3 domain binding kinase family member 2" P0C263 19 55528611-55537133 "Enzymes, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Group enriched" "Detected in some" 28 "heart muscle: 87.2;tongue: 28.8" "Group enriched" "Detected in some" 6 "Early spermatids: 1.5;Late spermatids: 2.3" "Cancer enhanced" "Detected in some" "ovarian cancer: 1.3" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 2.5;MCF7: 2.5;NTERA-2: 7.7;RH-30: 7.0;SuSa: 3.5;U-2 OS: 3.7" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA030631 Enhanced NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 38: Heart - Muscle contraction" "Cluster 5: NTERA-2 - Transcription" "Cluster 31: Spermatids - Spermatogenesis" "HPA030631: AB_10602088" "unprognostic (1.33e-1)" "unprognostic (1.85e-3)" "unprognostic (4.57e-1)" "unprognostic (3.49e-1)" "unprognostic (5.43e-3)" "unprognostic (4.18e-3)" "unprognostic (2.08e-1)" "unprognostic (6.58e-2)" "unprognostic (1.05e-1)" 0.6 0.0 0.1 0.0 0.2 0.5 0.0 0.9 0.1 0.0 0.8 0.0 0.2 0.3 0.0 0.2 0.0 0.1 87.2 0.2 0.1 0.0 0.1 0.0 0.1 0.1 0.0 0.1 0.7 0.0 0.0 0.0 0.2 0.1 0.0 0.1 0.4 0.0 1.9 0.1 0.0 0.0 0.0 0.0 0.0 2.0 0.1 0.0 0.0 28.8 0.0 0.0 0.0 0.3 0.0 2.5 0.1 0.1 0.0 0.0 0.1 0.4 0.0 0.6 1.3 0.4 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.2 0.0 0.1 2.2 0.0 0.0 0.0 0.3 0.0 0.9 0.0 0.2 0.1 0.0 0.0 0.0 0.5 2.5 0.0 0.1 7.7 0.0 0.0 0.2 7.0 0.0 0.1 0.0 0.5 0.0 0.0 0.1 0.0 3.5 0.0 0.2 0.1 0.0 3.7 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.7 0.0 0.0 0.1 0.0 0.0 0.1 0.2 0.9 0.1 0.2 0.1 0.1 0.0 0.2 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 SBK3 SgK110 ENSG00000231274 "SH3 domain binding kinase family member 3" P0C264 19 55540656-55545543 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "heart muscle: 32.5;tongue: 15.1" "Cell type enriched" "Detected in single" 5 "Cardiomyocytes: 2.1" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 5.0;CACO-2: 1.8;CAPAN-2: 2.9;K-562: 1.2;NTERA-2: 1.3;RH-30: 2.2" "Not detected" "Not detected" HPA078322 Approved Mitochondria NA NA "Cluster 38: Heart - Muscle contraction" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 43: Cardiomyocytes - Nuclear processes" Mitochondria "HPA078322: AB_2732379" "unprognostic (2.15e-1)" "unprognostic (1.99e-3)" "unprognostic (2.71e-1)" "unprognostic (1.39e-3)" "unprognostic (7.52e-2)" "unprognostic (2.83e-1)" "unprognostic (5.47e-5)" "unprognostic (4.64e-3)" "unprognostic (7.24e-2)" "unprognostic (1.65e-1)" "unprognostic (3.38e-1)" "unprognostic (3.08e-3)" "unprognostic (1.21e-2)" "unprognostic (4.92e-2)" "unprognostic (2.41e-1)" "unprognostic (1.79e-1)" 2.5 0.0 0.0 0.1 0.0 0.0 1.0 0.4 0.0 0.3 0.0 0.1 0.4 0.2 0.0 2.0 0.2 0.3 32.5 0.0 0.0 0.4 0.1 0.5 0.0 0.0 0.0 0.0 0.4 0.1 0.2 0.0 0.3 0.2 0.0 0.0 0.5 0.0 6.5 0.2 0.2 0.2 0.1 0.0 0.4 0.2 0.1 0.0 0.5 15.1 0.0 0.3 0.1 0.1 0.0 5.0 0.4 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.1 1.8 2.9 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 1.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.5 0.0 0.0 1.3 0.0 0.3 0.1 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.6 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.1 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 SCP2 ENSG00000116171 "Sterol carrier protein 2" P22307 1 52927276-53051698 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Lipid transport, Transport" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 1116.8" "Cell type enhanced" "Detected in all" "Hepatocytes: 1240.7;Proximal enterocytes: 769.0;Proximal tubular cells: 881.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027101, HPA027135, HPA027317" Supported Supported Nucleoplasm,Peroxisomes NA NA 640000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 2: Hepatocytes - Metabolism" Peroxisomes Nucleoplasm "HPA027101: AB_1856634, HPA027135: AB_1856633, HPA027317: AB_10610422" "unprognostic (7.51e-2)" "unprognostic (5.23e-2)" "prognostic favorable (7.05e-5)" "unprognostic (9.68e-2)" "unprognostic (1.53e-2)" "unprognostic (5.53e-2)" "unprognostic (1.87e-3)" "unprognostic (1.22e-2)" "unprognostic (1.62e-2)" "unprognostic (1.59e-1)" "unprognostic (4.53e-2)" "unprognostic (6.16e-2)" "prognostic favorable (7.85e-8)" "unprognostic (1.49e-2)" "unprognostic (1.09e-1)" "unprognostic (8.64e-2)" "unprognostic (1.13e-2)" 203.7 125.5 68.5 92.7 71.6 111.2 196.6 74.2 90.1 153.8 79.2 256.7 336.3 94.6 165.5 140.2 119.7 144.6 162.4 65.8 76.1 319.8 1116.8 140.6 106.0 75.4 72.3 94.5 119.2 130.9 64.7 79.0 77.9 150.9 270.5 76.6 114.0 97.3 142.0 130.6 305.7 112.9 75.6 83.9 234.4 63.4 74.7 131.9 140.9 152.8 125.5 139.2 76.9 78.9 120.6 64.8 85.5 157.9 273.6 232.6 92.7 140.0 208.9 90.1 129.2 58.7 127.5 114.7 147.6 206.6 105.3 82.5 59.6 131.0 136.5 168.2 86.4 123.4 88.8 122.1 182.0 179.9 197.5 190.2 175.0 107.1 52.9 196.2 260.0 132.6 111.5 58.2 184.7 70.1 200.7 155.2 94.6 304.4 126.0 101.9 150.9 158.3 252.2 192.2 70.9 85.3 122.0 246.3 121.6 189.6 125.9 201.4 203.8 122.4 63.4 213.2 114.9 95.9 131.0 134.2 159.0 175.7 113.8 285.6 193.7 286.0 185.9 208.8 152.1 150.8 144.9 184.6 230.5 132.6 120.8 171.4 29.4 176.8 204.2 150.9 195.2 289.5 68.5 71.6 74.2 90.1 65.8 76.1 75.4 72.3 77.9 75.6 74.7 78.9 167.0 134.6 198.4 52.2 91.1 150.4 123.8 222.2 110.4 37.5 189.8 86.0 157.4 258.7 166.2 185.8 31.3 182.7 128.3 512.7 473.5 168.1 57.4 150.4 81.6 126.8 235.1 93.4 45.0 162.4 156.5 124.3 180.4 125.3 138.4 54.0 146.7 1240.7 203.5 42.1 54.4 462.7 250.3 230.1 173.1 51.4 184.2 148.8 192.1 42.2 154.6 132.0 181.3 48.2 44.3 157.4 503.4 171.9 76.6 118.1 769.0 881.0 178.2 34.1 78.9 72.0 110.6 20.4 19.4 150.0 170.8 133.9 132.9 110.3 336.4 187.8 SELENOI "EPT1, KIAA1724, SELI, SEPI" ENSG00000138018 "Selenoprotein I" Q9C0D9 2 26308547-26395891 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" Transferase "Disease variant, Hereditary spastic paraplegia, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Collecting duct cells: 22.0;Endometrial ciliated cells: 16.3;Glandular and luminal cells: 15.3;Pancreatic endocrine cells: 13.6;Syncytiotrophoblasts: 16.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA064125 Approved NA NA "Cluster 37: B-cells - Transcription" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" "HPA064125: " "unprognostic (6.29e-2)" "unprognostic (7.46e-2)" "unprognostic (1.38e-3)" "unprognostic (3.05e-3)" "unprognostic (1.50e-1)" "unprognostic (1.39e-2)" "unprognostic (7.44e-3)" "unprognostic (5.00e-3)" "unprognostic (7.79e-2)" "unprognostic (2.55e-2)" "unprognostic (6.65e-2)" "unprognostic (9.40e-2)" "unprognostic (1.52e-2)" "unprognostic (2.95e-1)" "unprognostic (1.76e-1)" "unprognostic (9.87e-3)" "unprognostic (1.42e-2)" 3.6 6.4 7.9 5.5 8.4 12.1 8.1 11.2 10.6 5.4 5.0 8.6 12.3 4.1 5.4 11.1 3.5 4.0 3.9 10.3 9.3 7.9 23.2 4.4 5.7 6.8 7.3 3.5 9.0 17.2 4.5 4.7 8.6 6.2 8.7 9.3 6.2 4.2 7.0 18.3 18.4 3.7 9.7 4.3 7.1 4.4 7.2 6.3 7.1 6.6 6.1 7.5 7.1 10.0 42.7 25.7 20.9 21.0 12.8 10.2 32.0 20.3 9.2 10.0 10.2 54.5 26.6 49.5 24.2 9.5 21.4 34.1 32.4 17.9 14.4 13.7 15.4 31.3 17.5 32.3 12.2 41.9 9.7 8.1 15.6 22.3 21.9 6.1 9.4 17.6 35.9 16.6 13.5 18.4 25.1 20.7 26.8 21.6 17.4 22.6 49.2 25.0 19.3 32.4 45.7 19.4 17.3 36.2 16.4 17.3 17.4 12.4 15.1 17.1 22.0 22.7 31.7 22.6 60.8 65.8 17.5 25.4 15.6 0.0 0.7 0.0 0.9 1.0 0.9 2.5 0.9 1.2 0.7 1.0 1.2 2.0 0.2 0.9 0.9 1.3 1.8 0.4 7.9 8.4 11.2 10.6 10.3 9.3 6.8 7.3 8.6 9.7 7.2 10.0 9.1 12.8 8.7 0.0 3.0 0.0 0.0 0.0 0.0 0.0 12.2 7.1 0.0 0.0 3.1 22.0 0.0 6.1 11.7 0.0 0.0 10.4 0.0 16.3 12.8 3.7 0.0 0.0 0.0 10.4 6.2 2.9 0.0 15.3 1.3 8.6 0.0 0.0 6.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.6 0.0 0.0 0.0 0.0 13.6 0.0 0.0 3.9 0.0 0.0 5.6 2.2 0.0 0.0 0.0 3.5 0.0 0.0 0.0 0.0 16.6 4.7 11.5 0.0 0.0 SELENOO SELO ENSG00000073169 "Selenoprotein O" Q9BVL4 22 50200979-50217616 "Enzymes, Predicted intracellular proteins" "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 27.9" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 21.1;Granulosa cells: 34.7;Proximal tubular cells: 41.7;Theca cells: 29.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA071795, HPA079100" Approved Supported "Mitotic chromosome,Mitochondria" "Intracellular and membrane" Yes NA "Cluster 52: Eosinophils - Transcription" "Cluster 85: Liver - Metabolism" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 7: Non-specific - Mitochondria" Mitochondria "Mitotic chromosome" "HPA071795: , HPA079100: " "unprognostic (1.79e-1)" "unprognostic (2.07e-3)" "unprognostic (1.60e-1)" "unprognostic (2.50e-3)" "unprognostic (3.89e-1)" "unprognostic (2.33e-2)" "unprognostic (2.85e-2)" "unprognostic (5.91e-2)" "unprognostic (1.51e-1)" "unprognostic (5.62e-2)" "unprognostic (8.20e-3)" "unprognostic (8.91e-2)" "unprognostic (1.81e-2)" "unprognostic (7.31e-2)" "unprognostic (1.98e-1)" "unprognostic (2.52e-1)" "prognostic favorable (8.32e-4)" 6.7 6.7 2.3 4.5 3.4 13.9 4.8 11.7 6.8 5.6 2.5 5.3 8.0 5.9 2.8 8.2 5.7 4.1 5.3 3.0 1.1 6.6 27.9 4.7 6.4 4.6 2.7 5.0 13.1 3.0 4.1 3.0 3.7 5.6 2.0 2.9 7.7 4.1 12.3 8.2 6.5 2.4 2.3 6.5 7.0 3.7 3.1 4.4 5.1 4.1 3.9 5.1 6.1 6.0 12.0 7.7 4.2 4.7 5.6 4.1 8.6 11.8 5.6 7.0 5.5 10.6 7.5 7.9 9.2 4.7 3.9 26.2 6.5 10.7 1.4 2.3 29.9 5.7 17.4 6.4 2.8 10.6 6.9 5.4 7.2 4.5 3.5 4.5 5.8 5.3 7.8 5.6 2.9 18.6 5.7 16.4 3.7 2.8 15.6 17.6 5.9 11.8 4.3 15.3 8.4 9.3 12.8 11.3 7.5 2.1 8.7 7.5 9.5 6.0 8.3 6.5 7.1 13.8 3.6 4.7 6.8 6.9 3.5 0.0 1.1 1.3 0.2 0.4 0.5 0.0 0.2 0.5 1.1 0.2 0.1 0.4 0.5 0.0 0.4 0.4 0.2 0.3 2.3 3.4 11.7 6.8 3.0 1.1 4.6 2.7 3.7 2.3 3.1 6.0 11.8 0.0 21.1 0.0 4.1 0.0 0.0 0.0 0.0 0.0 13.3 13.2 0.0 0.0 5.6 9.2 0.0 3.1 12.2 0.0 15.6 3.6 0.0 11.8 10.9 3.0 0.0 0.0 0.0 4.6 2.4 6.0 0.0 15.2 3.8 34.7 0.0 0.0 4.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.5 0.0 0.0 2.0 0.0 0.0 0.0 0.0 4.7 0.0 0.0 4.5 0.0 0.0 41.7 3.6 0.0 0.0 0.0 4.8 0.0 0.0 0.0 0.0 1.9 5.5 29.6 0.0 0.0 SEPHS1 "SPS, SPS1" ENSG00000086475 "Selenophosphate synthetase 1" P49903 10 13317428-13348298 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA037645, HPA062118" Enhanced Uncertain Nucleoplasm NA NA 21000 "Cluster 27: Non-specific - Gene expression" "Cluster 8: Non-specific - Mitochondria" "Cluster 5: NTERA-2 - Transcription" "Cluster 65: Plasmacytoid DCs - Unknown function" Nucleoplasm "HPA037645: AB_10671631, HPA062118: AB_2732676" "unprognostic (8.18e-3)" "unprognostic (1.79e-1)" "unprognostic (1.06e-3)" "unprognostic (2.07e-1)" "unprognostic (3.50e-2)" "unprognostic (2.99e-2)" "prognostic unfavorable (2.16e-7)" "unprognostic (2.66e-2)" "unprognostic (1.43e-1)" "unprognostic (2.61e-2)" "prognostic favorable (3.12e-4)" "unprognostic (1.09e-1)" "unprognostic (1.38e-2)" "unprognostic (1.10e-1)" "unprognostic (1.85e-1)" "unprognostic (1.66e-1)" "unprognostic (5.11e-2)" 27.8 28.6 23.2 23.6 23.9 25.3 33.5 25.3 22.3 25.6 28.1 31.2 23.2 32.3 35.9 24.6 35.3 23.8 30.8 21.7 24.1 56.5 48.6 24.3 29.3 26.7 28.4 35.7 33.6 48.1 23.5 27.8 23.1 26.4 32.7 25.0 26.9 24.7 33.3 20.9 24.6 33.2 25.9 21.8 25.6 22.1 24.6 64.3 55.4 36.6 34.3 24.8 17.4 24.4 127.7 90.8 182.4 176.3 59.4 45.1 85.8 55.4 42.6 115.6 97.9 103.5 116.4 123.1 67.2 65.0 55.9 79.6 195.2 91.4 120.5 186.7 80.9 67.4 66.8 132.9 61.4 92.0 41.4 39.6 64.6 67.7 39.5 53.9 95.0 255.9 90.7 97.5 83.2 168.1 228.8 39.3 301.8 119.8 40.9 176.3 88.8 73.7 62.2 51.0 64.5 119.5 169.6 74.1 75.7 157.7 93.8 96.1 64.1 51.1 96.3 67.6 117.6 71.3 143.4 228.1 41.2 67.6 41.9 10.2 11.6 8.8 7.7 17.1 9.5 9.5 7.8 8.9 13.6 6.4 10.0 9.4 1.7 15.4 24.8 15.4 13.3 8.3 23.2 23.9 25.3 22.3 21.7 24.1 26.7 28.4 23.1 25.9 24.6 24.4 24.1 12.8 13.1 8.1 12.3 17.2 16.5 19.3 9.6 17.1 23.8 19.4 14.1 20.0 18.0 22.0 0.0 31.6 27.1 17.6 33.2 26.4 13.5 16.9 15.4 26.1 16.7 19.3 8.2 30.1 45.2 18.0 11.7 16.1 15.8 27.7 19.6 32.7 21.1 21.9 8.3 13.7 20.3 10.1 11.7 14.1 14.9 13.1 16.0 4.7 8.0 35.2 9.2 4.0 12.9 34.1 15.3 18.4 18.7 17.5 16.4 44.6 13.4 15.6 6.6 14.2 26.1 17.6 21.2 15.0 16.9 25.6 13.2 25.9 18.0 15.1 SEPHS2 "SPS2, SPS2b" ENSG00000179918 "Selenophosphate synthetase 2" Q99611 16 30443631-30445874 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 402.6" "Cell type enhanced" "Detected in many" "Distal tubular cells: 385.4;Proximal tubular cells: 384.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HMC-1: 477.5" "Low region specificity" "Detected in all" HPA047931 Approved Approved Nucleoplasm No No 29000 "Cluster 26: Non-specific - Mitochondria" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 3: HMC-1 - Innate immune response" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "HPA047931: AB_2680216" "unprognostic (5.33e-2)" "unprognostic (2.02e-1)" "unprognostic (1.92e-2)" "unprognostic (9.85e-2)" "unprognostic (2.67e-2)" "unprognostic (6.29e-2)" "unprognostic (5.67e-2)" "unprognostic (7.69e-3)" "unprognostic (2.38e-1)" "unprognostic (9.86e-2)" "unprognostic (9.66e-3)" "unprognostic (1.49e-1)" "prognostic favorable (4.35e-8)" "unprognostic (2.24e-2)" "unprognostic (1.35e-1)" "unprognostic (3.25e-2)" "unprognostic (3.62e-2)" 27.5 30.6 16.8 33.7 17.5 26.0 33.8 18.5 19.9 24.8 21.2 75.5 136.0 19.9 23.9 20.4 20.5 34.0 27.8 18.5 20.5 158.5 402.6 28.8 44.8 18.5 18.9 14.9 35.2 48.9 20.4 25.1 19.5 28.7 65.9 19.7 33.6 23.2 41.7 21.1 105.8 25.9 18.6 29.8 62.5 11.5 20.2 43.5 37.7 32.3 41.9 27.7 14.2 19.8 77.6 68.9 23.8 83.1 71.7 45.7 62.5 52.3 64.5 50.5 62.2 42.9 57.7 110.8 79.0 56.0 45.7 42.1 44.5 47.9 51.0 71.2 137.5 110.8 35.9 204.0 90.5 62.0 477.5 58.4 100.5 47.6 87.7 31.6 47.0 80.1 91.1 69.7 45.4 114.5 93.9 127.8 59.3 58.0 51.4 90.2 41.8 85.3 62.6 68.9 50.5 43.1 44.8 129.3 179.7 47.8 113.7 204.2 39.6 52.2 37.1 50.9 32.0 59.6 103.4 57.6 45.3 114.3 59.7 8.7 19.4 30.2 14.8 16.1 22.2 17.8 20.9 21.4 21.6 20.2 25.0 17.2 17.6 31.9 20.5 15.4 22.8 14.8 16.8 17.5 18.5 19.9 18.5 20.5 18.5 18.9 19.5 18.6 20.2 19.8 76.2 44.8 40.3 3.9 34.3 37.5 1.4 47.6 58.6 0.5 66.2 52.7 49.4 1.5 39.4 64.4 0.0 1.3 41.5 108.9 385.4 112.2 0.1 34.2 25.1 32.4 35.5 20.8 6.7 82.7 1.1 30.4 68.8 59.2 31.0 20.5 0.7 9.1 1.4 0.0 8.6 31.0 63.1 2.9 34.9 0.1 0.0 42.5 44.4 5.6 37.1 0.2 1.0 5.5 4.6 57.4 42.4 0.0 30.6 1.6 11.1 384.9 27.2 1.1 0.0 2.0 49.4 0.8 0.8 45.4 42.6 1.2 35.7 52.6 46.0 0.9 SEPSECS "SLA, SLA/LP" ENSG00000109618 "Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase" Q9HD40 4 25120014-25160550 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Protein biosynthesis" "RNA-binding, Transferase, tRNA-binding" "Disease variant, Epilepsy, Mental retardation, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 26.1" "Cell type enhanced" "Detected in many" "Hepatocytes: 42.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA070409 Approved Vesicles NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 16: U-266 - Nucleosome" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" Vesicles "HPA070409: AB_2686265" "unprognostic (1.83e-1)" "unprognostic (4.09e-2)" "unprognostic (6.37e-3)" "unprognostic (5.86e-2)" "unprognostic (9.63e-2)" "unprognostic (4.61e-3)" "unprognostic (1.82e-3)" "unprognostic (6.33e-2)" "unprognostic (1.24e-1)" "unprognostic (3.34e-1)" "unprognostic (2.52e-1)" "unprognostic (3.56e-2)" "unprognostic (4.45e-3)" "unprognostic (4.64e-2)" "unprognostic (1.65e-1)" "unprognostic (1.16e-2)" "unprognostic (2.13e-3)" 4.7 3.5 2.1 1.7 2.1 0.7 4.4 2.0 3.0 4.2 1.6 5.3 4.8 3.8 2.6 3.2 3.8 2.5 2.7 2.0 2.1 8.2 26.1 3.9 2.1 2.2 2.0 4.9 7.4 3.3 3.0 2.8 2.1 3.4 2.7 1.5 3.9 2.0 3.4 5.2 7.6 1.3 2.0 5.6 5.0 4.0 2.1 5.2 4.8 2.6 2.0 3.8 3.5 2.3 1.7 1.0 3.0 1.3 3.9 4.9 2.5 1.1 1.9 2.6 2.3 0.6 2.6 2.9 1.4 1.0 2.6 1.3 3.5 1.2 2.0 1.9 1.3 2.5 1.0 1.8 4.0 2.0 3.3 4.0 4.2 1.0 3.7 3.1 2.5 4.3 7.0 2.5 1.6 0.7 4.4 6.2 2.1 1.8 2.5 1.3 4.3 1.7 3.7 0.7 1.6 2.4 1.3 1.4 4.7 1.9 1.5 5.5 1.0 1.4 0.7 0.7 1.7 2.3 6.2 1.6 1.4 5.4 1.8 0.0 0.2 0.1 0.1 0.6 0.2 0.0 0.2 0.0 0.2 0.1 0.2 0.1 0.0 0.1 0.1 0.0 0.0 0.1 2.1 2.1 2.0 3.0 2.0 2.1 2.2 2.0 2.1 2.0 2.1 2.3 5.7 0.0 7.2 9.4 6.6 2.4 1.7 3.9 2.8 3.0 5.5 4.3 5.3 22.8 4.3 16.5 0.0 5.5 4.1 10.2 7.9 5.4 30.0 7.3 6.2 6.1 6.1 8.2 5.3 4.7 3.5 4.8 8.2 5.4 3.8 7.9 6.1 42.6 6.1 5.0 7.2 7.7 4.1 8.1 4.5 18.1 3.4 6.6 3.6 14.0 8.0 3.2 4.1 16.1 18.5 5.4 6.0 6.4 6.9 2.7 20.0 20.9 10.2 2.4 0.0 4.9 4.4 26.0 18.3 5.3 3.3 5.9 6.2 7.6 7.8 1.1 SETD1A "KIAA0339, KMT2F, Set1" ENSG00000099381 "SET domain containing 1A, histone lysine methyltransferase" O15047 16 30957754-30984664 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Transcription, Transcription regulation" "Activator, Chromatin regulator, Methyltransferase, RNA-binding, Transferase" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020646, HPA058376" Enhanced Supported "Nuclear speckles" NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 71: Testis - DNA repair" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" "Nuclear speckles" "HPA020646: AB_1856752, HPA058376: AB_2683695" "unprognostic (8.62e-2)" "unprognostic (1.93e-2)" "unprognostic (3.96e-2)" "unprognostic (1.53e-1)" "unprognostic (1.85e-1)" "unprognostic (1.40e-2)" "prognostic unfavorable (8.47e-4)" "unprognostic (5.01e-2)" "unprognostic (1.54e-1)" "unprognostic (3.18e-1)" "unprognostic (5.77e-2)" "unprognostic (1.72e-1)" "unprognostic (1.55e-1)" "unprognostic (1.27e-1)" "unprognostic (2.12e-1)" "unprognostic (1.70e-2)" "unprognostic (1.94e-1)" 10.2 10.0 6.0 7.3 5.5 20.1 10.0 8.4 8.3 11.0 3.0 13.0 6.6 13.0 2.8 9.0 10.5 4.1 8.5 5.5 5.5 8.4 10.4 8.2 8.6 5.6 5.4 12.4 10.6 8.0 11.9 5.0 5.4 10.2 3.3 3.1 9.3 6.1 15.1 12.3 10.5 6.3 4.1 11.8 10.0 20.8 6.0 10.0 11.8 7.1 5.1 10.2 9.3 6.9 13.1 24.4 15.9 19.4 8.7 6.3 18.0 13.6 10.6 11.9 10.1 20.2 12.8 34.2 15.2 13.0 12.0 16.4 15.0 14.6 9.3 18.5 56.1 16.0 47.1 23.2 8.9 26.6 26.2 11.0 11.3 17.1 10.8 9.2 9.3 19.5 32.3 19.0 6.4 27.2 32.3 27.7 23.4 9.0 15.4 48.7 15.9 21.9 7.6 13.9 17.6 18.1 18.7 15.1 10.8 8.7 16.2 22.1 12.8 17.7 17.1 11.6 14.9 28.0 36.2 32.4 14.3 22.9 13.5 0.0 0.1 0.6 0.2 0.3 0.3 0.0 0.2 0.2 0.1 0.5 0.1 0.2 0.0 0.2 0.1 0.6 0.1 0.2 6.0 5.5 8.4 8.3 5.5 5.5 5.6 5.4 5.4 4.1 6.0 6.9 7.8 3.2 9.2 9.1 8.8 15.7 5.1 3.8 15.4 8.1 9.5 8.3 3.9 5.7 4.0 7.3 6.2 4.6 11.4 6.8 0.0 4.2 3.1 6.1 8.2 9.9 10.3 6.7 6.4 4.2 3.7 7.8 6.1 8.6 3.8 9.5 7.5 9.1 6.5 13.5 6.1 7.9 2.0 4.7 7.1 2.9 9.9 5.5 8.8 6.5 4.7 4.8 7.2 2.5 5.7 5.4 4.8 11.7 7.9 8.3 5.1 2.8 4.0 5.2 6.6 10.8 7.8 17.5 23.3 15.7 12.9 2.9 8.6 10.3 6.9 4.8 SETD1B "KIAA1076, KMT2G, Set1B" ENSG00000139718 "SET domain containing 1B, histone lysine methyltransferase" Q9UPS6 12 121804009-121832656 "Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" "Activator, Chromatin regulator, Methyltransferase, RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021667, HPA059412" Approved Enhanced Nucleoplasm NA NA "Cluster 34: Basophils - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 24: NB-4 - Immune response" "Cluster 59: Non-specific - Transcription" Nucleoplasm "HPA021667: AB_1856753, HPA059412: AB_2684006" "unprognostic (1.69e-1)" "unprognostic (2.38e-2)" "unprognostic (6.32e-2)" "unprognostic (3.51e-1)" "unprognostic (2.06e-1)" "unprognostic (2.75e-2)" "unprognostic (5.32e-2)" "unprognostic (1.35e-1)" "unprognostic (1.28e-2)" "unprognostic (5.65e-2)" "unprognostic (1.59e-2)" "unprognostic (1.75e-1)" "unprognostic (7.33e-2)" "unprognostic (1.55e-1)" "unprognostic (1.28e-1)" "unprognostic (1.39e-1)" "unprognostic (2.13e-2)" 14.3 8.9 2.8 8.6 2.5 15.1 12.1 7.6 4.4 19.4 1.3 28.5 7.5 26.0 4.7 14.0 19.6 4.5 8.0 2.7 0.7 8.4 11.3 9.2 6.9 1.7 1.4 15.8 12.5 5.5 9.2 5.5 0.7 15.6 3.7 3.4 11.4 10.0 9.0 11.6 15.6 7.1 0.5 13.1 16.7 9.4 1.6 8.4 13.9 4.2 4.8 22.0 14.1 1.5 7.4 14.8 7.4 12.5 6.9 4.7 11.2 6.8 5.4 5.1 2.9 8.1 4.4 5.4 6.1 7.6 3.2 11.3 8.6 5.3 3.0 9.7 10.5 16.3 20.3 7.1 5.9 15.3 14.0 5.7 6.4 7.0 5.6 6.2 5.6 10.6 17.1 3.7 3.9 17.1 22.5 21.5 10.6 3.6 8.5 17.3 4.8 7.9 5.0 15.1 9.0 6.9 15.0 10.5 5.7 5.5 12.8 13.8 9.5 7.6 9.4 10.8 7.7 7.3 4.0 3.2 6.3 9.7 8.8 1.4 0.2 0.6 0.4 0.5 0.3 0.3 0.3 0.4 0.2 0.3 0.5 0.3 1.0 0.3 0.2 0.5 0.3 0.2 2.8 2.5 7.6 4.4 2.7 0.7 1.7 1.4 0.7 0.5 1.6 1.5 10.1 3.2 7.3 9.8 11.2 11.7 3.2 5.7 26.2 13.8 12.7 9.5 9.7 10.0 6.7 5.5 8.4 7.9 17.6 8.5 0.0 5.1 9.8 13.9 14.5 9.5 7.3 7.8 10.6 7.2 7.0 8.5 8.6 20.3 3.8 10.1 12.1 13.8 6.5 11.8 11.7 7.8 4.1 17.7 14.8 21.4 11.5 10.8 1.8 5.6 13.9 5.0 9.2 5.0 6.8 6.5 10.5 10.1 11.2 9.1 6.8 3.2 5.4 10.0 6.6 10.6 12.9 11.3 3.5 29.4 12.9 13.1 13.3 8.1 6.6 9.1 SETD2 "FLJ23184, HIF-1, HYPB, KIAA1732, KMT3A" ENSG00000181555 "SET domain containing 2, histone lysine methyltransferase" Q9BYW2 3 47016429-47164113 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Antiviral defense, Differentiation, DNA damage, DNA repair, Host-virus interaction, Immunity, Innate immunity, Transcription, Transcription regulation" "Activator, Chromatin regulator, Developmental protein, Methyltransferase, Transferase" "Autism spectrum disorder, Cancer-related genes, Disease variant, Mental retardation, Tumor suppressor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA042451 Approved Approved "Nuclear speckles,Cytosol" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 52: Non-specific - Transcription" "Nuclear speckles" Cytosol "HPA042451: AB_10806239" "unprognostic (2.78e-1)" "unprognostic (1.01e-1)" "unprognostic (6.08e-2)" "unprognostic (1.01e-1)" "unprognostic (3.37e-2)" "unprognostic (1.37e-2)" "unprognostic (1.40e-2)" "unprognostic (1.01e-2)" "prognostic unfavorable (8.19e-4)" "unprognostic (6.19e-2)" "unprognostic (2.45e-1)" "unprognostic (7.84e-2)" "prognostic favorable (7.99e-6)" "unprognostic (1.03e-1)" "unprognostic (1.91e-1)" "unprognostic (8.79e-2)" "unprognostic (5.43e-2)" 9.9 6.5 8.2 10.7 10.5 23.8 10.3 24.1 8.3 12.6 10.8 9.7 9.1 13.3 6.1 9.8 11.0 8.5 7.2 6.2 6.7 10.8 10.0 9.4 13.5 8.3 8.5 15.3 13.3 16.2 2.2 11.4 8.4 10.2 11.0 10.6 9.6 9.7 11.1 9.0 10.3 11.9 8.1 11.4 10.7 13.1 7.9 19.2 15.5 14.5 13.3 9.8 4.0 12.8 21.1 13.2 25.4 14.5 15.3 18.9 11.3 17.9 17.0 20.8 19.9 15.4 13.8 43.5 11.6 25.5 20.0 12.4 29.5 17.6 27.6 27.5 12.2 47.3 24.8 12.4 11.7 34.1 26.5 15.2 17.3 20.7 24.6 15.3 20.1 22.8 29.9 16.6 17.8 9.5 26.7 8.5 20.6 9.4 15.4 17.5 25.6 23.2 12.4 26.6 10.9 17.6 29.5 11.8 12.0 17.2 12.9 27.5 26.7 24.6 18.1 21.5 29.9 22.0 25.4 43.7 14.2 19.6 14.6 1.3 1.2 2.9 2.0 1.1 1.1 2.2 1.2 1.6 1.4 2.5 1.7 1.6 3.3 3.6 1.1 1.5 0.6 0.6 8.2 10.5 24.1 8.3 6.2 6.7 8.3 8.5 8.4 8.1 7.9 12.8 50.5 48.1 58.8 115.9 58.3 33.3 22.6 15.6 54.1 40.5 31.0 29.1 67.2 27.1 53.2 11.0 41.7 20.3 58.2 32.6 11.7 20.9 26.1 62.8 63.0 41.2 22.1 38.9 131.4 22.4 12.7 39.2 56.6 66.2 58.8 68.9 23.6 29.8 16.8 26.9 129.4 28.2 14.2 28.8 26.5 35.1 30.4 42.7 17.8 148.9 37.9 22.7 43.3 113.1 143.2 23.7 22.3 33.1 54.0 31.2 24.6 11.5 49.7 39.9 13.1 56.1 42.6 71.0 29.3 60.2 35.7 18.5 65.3 57.1 29.5 34.7 SETD3 "C14orf154, FLJ23027" ENSG00000183576 "SET domain containing 3, actin histidine methyltransferase" Q86TU7 14 99397748-99480889 "Enzymes, Predicted intracellular proteins" "Actin-binding, Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 206.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003591, HPA003639" Approved Approved Mitochondria NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 18: U-2197 - ECM organization" "Cluster 66: Spermatocytes - Spermatogenesis" Mitochondria "HPA003591: AB_1079930, HPA003639: AB_1079931" "unprognostic (6.82e-2)" "unprognostic (2.66e-2)" "unprognostic (8.07e-2)" "unprognostic (2.16e-2)" "unprognostic (2.42e-1)" "prognostic unfavorable (6.46e-4)" "unprognostic (1.04e-2)" "unprognostic (3.24e-2)" "unprognostic (3.29e-1)" "unprognostic (2.73e-2)" "unprognostic (2.01e-1)" "unprognostic (4.42e-1)" "prognostic favorable (1.89e-15)" "unprognostic (6.81e-2)" "unprognostic (3.21e-1)" "unprognostic (2.20e-1)" "unprognostic (2.62e-3)" 38.8 26.6 49.6 25.2 50.6 23.5 30.1 46.9 59.2 29.2 45.1 49.5 36.3 26.2 83.5 36.6 46.6 29.4 79.0 48.1 47.8 96.1 47.2 37.4 24.1 46.4 45.5 22.0 37.6 40.1 21.6 42.6 45.9 35.9 37.9 64.5 57.8 41.6 174.0 31.6 37.4 39.4 46.2 28.4 29.1 85.0 52.2 24.5 53.4 118.2 24.8 36.3 24.4 52.1 39.9 44.6 33.1 31.7 37.6 42.0 117.1 49.4 37.4 50.3 51.1 43.5 65.7 38.8 39.5 55.6 39.5 50.4 40.8 55.2 79.6 38.5 22.0 35.3 27.8 40.2 46.9 53.6 51.2 29.6 71.3 44.7 64.8 37.9 63.4 57.2 28.3 56.9 56.3 74.7 56.6 57.9 19.9 98.5 50.7 34.1 67.8 32.0 72.6 48.4 58.9 27.4 44.3 45.4 38.4 59.7 61.6 46.2 56.6 22.6 31.5 153.8 38.2 40.6 49.3 42.1 42.6 52.5 35.3 7.6 18.1 24.9 17.7 21.5 20.6 11.4 15.0 16.6 22.4 8.9 12.3 15.4 10.8 20.6 19.2 14.1 12.2 14.8 49.6 50.6 46.9 59.2 48.1 47.8 46.4 45.5 45.9 46.2 52.2 52.1 31.1 25.6 44.5 43.1 16.9 24.3 18.6 14.4 21.6 26.0 22.8 17.1 83.0 18.6 24.8 25.8 27.1 61.9 37.3 37.2 33.2 24.7 206.6 29.9 24.9 29.1 21.7 11.3 47.7 28.0 45.4 22.2 17.3 30.7 32.9 7.5 22.9 27.5 35.8 18.5 43.6 28.2 14.2 29.7 23.2 121.0 19.0 35.9 10.6 52.5 27.9 47.6 60.8 38.2 36.8 25.7 20.3 21.1 23.6 26.1 30.1 101.5 28.1 39.5 6.6 25.3 23.0 130.4 73.0 25.0 32.4 30.0 27.9 9.2 30.5 20.8 SETD5 FLJ10707 ENSG00000168137 "SET domain containing 5" Q9C0A6 3 9397615-9479240 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Transcription, Transcription regulation" "Chromatin regulator, Methyltransferase, Transferase" "Autism, Autism spectrum disorder, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocyte precursor cells: 263.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB017093, HPA035574" Approved Enhanced Nucleoplasm NA NA "Cluster 15: NK-cells - Transcription" "Cluster 51: Non-specific - Unknown function" "Cluster 28: BEWO - Transcription regulation" "Cluster 68: Oligodendrocytes - Mixed function" Nucleoplasm "CAB017093: , HPA035574: AB_2674681" "unprognostic (6.46e-2)" "unprognostic (1.64e-1)" "unprognostic (3.44e-1)" "unprognostic (1.13e-1)" "unprognostic (1.22e-1)" "unprognostic (7.99e-2)" "prognostic unfavorable (6.21e-4)" "unprognostic (5.52e-2)" "unprognostic (2.29e-1)" "unprognostic (3.22e-1)" "unprognostic (1.65e-1)" "unprognostic (4.04e-2)" "prognostic unfavorable (4.27e-4)" "unprognostic (6.65e-2)" "unprognostic (1.67e-1)" "unprognostic (4.04e-2)" "unprognostic (5.15e-3)" 24.9 28.1 22.3 19.3 22.0 14.9 25.4 33.7 24.9 29.5 20.9 30.5 15.2 27.6 30.2 25.0 30.2 18.8 23.0 23.5 22.3 18.3 27.6 33.5 23.1 20.5 20.3 33.2 28.5 18.0 26.5 24.0 21.1 25.6 20.9 33.9 28.3 20.4 23.9 32.8 25.6 23.2 18.6 26.1 23.9 17.8 22.2 25.5 30.5 21.5 26.7 26.5 28.1 24.2 25.3 28.6 57.8 27.0 36.5 33.6 138.5 24.9 30.2 31.6 35.4 29.1 30.2 53.5 14.3 33.4 29.8 20.0 50.6 29.8 35.5 38.4 27.6 50.6 56.4 29.8 36.7 42.0 31.9 35.0 52.2 49.3 55.1 37.3 35.7 35.6 50.0 40.0 32.6 36.4 35.7 38.1 42.2 19.5 23.9 37.7 47.6 26.2 29.6 37.7 22.3 34.6 34.2 29.8 22.6 52.6 39.7 30.8 41.6 35.3 41.6 21.0 28.9 27.4 34.2 83.6 26.9 30.4 33.2 0.4 0.4 0.2 0.9 0.2 0.8 0.7 0.6 0.7 0.3 0.7 0.5 0.5 1.1 1.1 0.2 0.8 0.1 0.1 22.3 22.0 33.7 24.9 23.5 22.3 20.5 20.3 21.1 18.6 22.2 24.2 51.5 41.7 50.6 136.1 53.6 93.9 54.4 28.5 86.6 110.6 45.1 26.2 25.5 41.5 50.0 42.3 114.7 38.9 50.4 39.1 3.9 37.3 7.9 45.9 60.3 62.5 62.4 34.3 175.0 34.0 41.3 62.2 45.9 49.4 48.1 60.6 63.1 50.1 24.4 55.5 188.5 51.9 26.4 32.4 70.7 11.7 66.8 30.8 44.4 108.7 39.7 33.4 39.1 263.9 131.7 44.2 46.2 53.8 67.7 88.2 39.4 12.8 52.9 60.9 13.1 65.3 52.8 50.6 37.8 75.2 91.5 57.3 49.6 56.2 47.8 84.2 SETD7 "KIAA1717, KMT7, SET7, SET7/9, Set9" ENSG00000145391 "SET domain containing 7, histone lysine methyltransferase" Q8WTS6 4 139495941-139606699 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" "Activator, Chromatin regulator, Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA058111 Enhanced Enhanced "Nucleoli,Nucleoli rim,Mitotic chromosome" Yes No "Cluster 12: Non-specific - Basic cellular processes" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "Nucleoli, Nucleoli rim" "Mitotic chromosome" "HPA058111: AB_2683607" "prognostic unfavorable (8.28e-4)" "unprognostic (7.07e-2)" "unprognostic (4.04e-1)" "unprognostic (2.07e-1)" "unprognostic (2.92e-1)" "unprognostic (4.82e-2)" "unprognostic (1.48e-2)" "unprognostic (2.04e-1)" "unprognostic (1.71e-2)" "unprognostic (9.10e-2)" "unprognostic (6.44e-2)" "unprognostic (7.75e-2)" "unprognostic (1.37e-1)" "unprognostic (6.16e-3)" "unprognostic (1.17e-1)" "unprognostic (6.92e-2)" "unprognostic (6.56e-3)" 44.7 18.5 17.8 15.1 17.7 9.7 27.3 19.3 17.3 40.5 21.2 23.5 7.3 33.0 12.6 28.1 18.8 26.7 41.0 16.6 19.4 10.1 50.1 19.2 11.7 25.0 20.3 19.6 21.9 34.7 8.8 19.1 24.7 35.1 15.3 11.5 16.2 20.6 106.6 22.7 12.1 34.8 24.6 17.0 20.1 14.4 24.5 10.1 14.1 73.7 15.9 23.4 18.2 29.2 28.4 37.2 13.0 7.8 77.1 65.9 29.6 65.7 67.3 32.4 27.1 22.7 37.2 68.0 25.5 110.5 22.4 13.9 44.3 51.3 52.4 32.8 33.0 8.9 45.5 0.8 38.4 31.9 12.9 57.7 58.6 52.1 54.6 41.2 41.7 27.8 5.5 96.1 42.3 46.8 21.0 4.6 6.4 40.8 23.9 19.7 48.4 37.3 31.5 25.3 55.3 18.5 44.7 63.5 15.3 12.6 25.3 28.0 68.8 57.1 40.7 68.6 55.2 89.6 86.8 42.2 65.9 31.1 28.0 0.5 3.9 0.2 0.3 2.0 2.7 1.0 1.1 1.1 4.4 1.2 0.4 0.2 0.9 0.2 3.2 2.1 3.7 1.2 17.8 17.7 19.3 17.3 16.6 19.4 25.0 20.3 24.7 24.6 24.5 29.2 28.7 6.4 18.8 17.3 8.9 17.2 14.5 14.1 12.5 5.4 24.0 14.7 43.1 20.0 15.0 9.2 12.5 26.2 4.2 4.1 0.0 22.7 1.3 3.5 35.9 29.4 1.2 3.6 21.1 21.2 16.7 39.8 16.8 7.5 2.5 2.9 37.1 70.6 20.4 8.4 42.4 13.6 18.3 31.0 20.9 4.3 23.0 19.5 10.6 19.7 19.0 15.0 0.0 36.2 29.2 22.4 4.1 28.2 13.2 38.4 1.3 4.5 14.0 12.9 19.7 35.2 23.3 3.7 2.7 17.9 22.0 46.1 9.8 9.5 11.7 20.4 SETDB1 "ESET, KG1T, KIAA0067, KMT1E, TDRD21" ENSG00000143379 "SET domain bifurcated histone lysine methyltransferase 1" Q15047 1 150926263-150964744 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Transcription, Transcription regulation" "Chromatin regulator, Methyltransferase, Repressor, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enriched" "Detected in all" 6 "U-698: 341.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018142, HPA058484" Uncertain Supported Nucleoplasm,Vesicles Yes No "Cluster 44: Non-specific - Transcription" "Cluster 34: Non-specific - Transcription" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 59: Non-specific - Transcription" Nucleoplasm Vesicles "HPA018142: AB_1856757, HPA058484: AB_2683731" "unprognostic (1.07e-1)" "unprognostic (4.08e-1)" "unprognostic (8.02e-2)" "unprognostic (2.24e-3)" "unprognostic (1.65e-2)" "unprognostic (9.57e-2)" "prognostic unfavorable (8.88e-4)" "unprognostic (6.03e-2)" "unprognostic (9.94e-3)" "unprognostic (7.13e-2)" "unprognostic (1.21e-1)" "unprognostic (6.65e-2)" "prognostic unfavorable (4.25e-4)" "unprognostic (1.59e-1)" "unprognostic (3.93e-2)" "unprognostic (3.14e-2)" "unprognostic (1.14e-1)" 13.5 11.3 7.1 15.2 8.2 18.1 16.7 12.8 8.9 14.4 8.7 13.4 12.5 18.1 13.1 11.8 15.3 11.5 8.2 6.7 7.9 11.7 11.5 13.4 19.6 8.2 7.6 19.4 13.3 15.7 8.6 17.7 7.6 11.4 15.5 14.2 12.3 12.2 16.4 14.4 13.7 16.5 6.0 19.9 13.4 25.1 8.4 21.6 15.5 11.7 20.3 13.1 12.7 10.3 22.9 26.3 37.1 24.6 17.5 23.2 61.7 18.6 21.2 26.2 22.2 17.9 31.1 44.9 24.9 20.7 10.4 28.1 35.0 20.0 20.7 21.8 43.3 25.5 27.3 20.8 24.7 45.3 23.2 30.5 22.0 21.8 34.8 26.6 31.2 28.3 43.4 35.6 18.9 44.1 31.6 26.4 51.1 32.1 20.6 36.3 24.3 33.4 20.1 25.9 27.1 49.1 28.4 32.9 22.5 44.5 35.7 60.4 21.2 15.3 15.7 17.0 26.3 36.6 42.3 341.6 15.7 15.7 15.1 6.9 8.3 5.7 5.8 11.6 6.1 6.1 5.3 6.6 9.7 8.3 5.7 5.9 4.8 6.3 8.5 6.5 3.5 4.3 7.1 8.2 12.8 8.9 6.7 7.9 8.2 7.6 7.6 6.0 8.4 10.3 8.5 6.4 14.0 15.3 15.3 5.5 9.3 6.6 10.2 11.0 9.8 10.7 5.5 10.0 7.8 7.3 18.8 13.9 8.8 6.6 3.9 7.6 26.1 10.8 13.3 8.3 3.6 9.2 19.6 5.7 8.5 9.1 10.2 10.7 7.6 17.9 11.4 8.1 9.9 6.7 19.4 9.7 12.2 17.2 5.1 31.0 10.2 13.9 1.8 23.4 14.4 6.2 14.4 15.6 23.5 8.1 9.5 9.8 8.9 8.2 7.6 6.4 11.0 10.4 6.6 10.2 10.3 24.4 15.9 10.9 5.1 10.0 10.2 14.6 10.7 7.8 SETMAR metnase ENSG00000170364 "SET domain and mariner transposase fusion gene" Q53H47 3 4303304-4317567 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair" "Chromatin regulator, DNA-binding, Endonuclease, Hydrolase, Methyltransferase, Multifunctional enzyme, Nuclease, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 25.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" HPA057999 Supported Nucleoli NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 89: Fibroblasts - ECM organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 47: Cytotrophoblasts - Unknown function" Nucleoli "HPA057999: AB_2683574" "unprognostic (1.59e-1)" "unprognostic (1.22e-2)" "unprognostic (5.24e-3)" "unprognostic (4.89e-2)" "unprognostic (7.73e-2)" "unprognostic (4.73e-2)" "prognostic unfavorable (2.85e-4)" "unprognostic (1.58e-2)" "unprognostic (1.54e-2)" "unprognostic (3.29e-1)" "unprognostic (1.19e-3)" "unprognostic (1.19e-1)" "prognostic favorable (6.61e-6)" "unprognostic (5.42e-1)" "unprognostic (3.06e-2)" "unprognostic (1.08e-1)" "unprognostic (1.26e-3)" 6.5 3.7 2.6 2.2 4.3 2.6 8.5 4.2 3.3 8.4 1.9 3.9 2.7 10.3 4.6 4.5 8.5 5.3 3.4 3.0 2.3 6.4 3.3 2.7 2.9 3.6 2.8 12.1 5.1 3.4 3.7 3.7 3.4 7.9 4.3 2.1 5.7 6.1 3.8 4.8 3.1 10.4 2.5 2.8 3.7 4.2 4.0 6.0 7.4 5.1 2.8 5.5 5.2 6.5 3.7 3.2 9.8 2.1 23.1 7.6 9.9 4.1 1.2 3.9 3.7 3.5 2.9 9.9 4.2 2.3 7.2 3.1 8.9 6.1 4.3 6.8 7.6 12.5 6.1 5.6 2.7 5.9 5.1 9.1 4.7 3.0 0.9 3.6 5.7 11.2 8.3 3.6 6.2 5.2 8.9 3.7 9.5 2.4 5.7 10.3 9.6 4.1 3.6 5.1 7.8 11.4 4.9 6.1 5.3 6.2 5.9 3.4 3.8 5.8 8.0 4.9 5.4 4.9 12.3 24.1 2.1 6.7 4.9 0.7 0.4 0.5 0.8 1.2 0.7 1.0 1.0 1.1 0.4 1.3 1.6 2.0 0.0 0.2 0.8 0.6 0.7 0.6 2.6 4.3 4.2 3.3 3.0 2.3 3.6 2.8 3.4 2.5 4.0 6.5 4.8 0.0 5.0 4.9 2.4 2.4 8.0 12.0 10.8 5.8 6.6 13.7 6.6 2.8 10.8 0.0 0.0 25.5 1.9 2.7 13.7 11.2 0.7 3.8 6.3 5.6 3.6 5.5 6.4 13.4 12.1 8.9 5.6 4.4 1.3 13.9 4.2 2.6 5.7 0.0 6.9 2.8 10.2 2.1 1.5 1.9 9.6 2.7 0.0 4.7 4.1 4.6 2.1 7.1 11.7 6.6 4.4 13.2 1.8 4.4 2.0 6.0 6.7 2.8 6.6 7.0 8.1 7.5 6.4 6.0 0.6 16.3 2.8 16.9 5.6 3.6 SGK1 SGK ENSG00000118515 "Serum/glucocorticoid regulated kinase 1" O00141 6 134169246-134318112 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Stress response" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "parathyroid gland: 1007.1" "Cell type enhanced" "Detected in many" "Langerhans cells: 1238.4;Proximal enterocytes: 789.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "classical monocyte: 43.4;eosinophil: 170.2;neutrophil: 91.6" "Group enriched" "Detected in all" 8 "granulocytes: 170.2;monocytes: 43.4" "Cell line enhanced" "Detected in many" "HHSteC: 298.1;RPTEC TERT1: 469.5;SK-MEL-30: 319.7;TIME: 373.9;U-266/84: 358.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB022085, CAB025148, HPA051251" Approved Enhanced "Nuclear speckles" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 41: Macrophages - Immune response" "Nuclear speckles" "CAB022085: , CAB025148: , HPA051251: AB_2681407" "unprognostic (2.05e-2)" "prognostic favorable (5.26e-4)" "unprognostic (1.12e-1)" "unprognostic (5.09e-3)" "unprognostic (2.76e-1)" "unprognostic (4.20e-2)" "unprognostic (4.53e-2)" "unprognostic (5.62e-2)" "unprognostic (4.03e-1)" "unprognostic (7.94e-2)" "unprognostic (1.78e-1)" "unprognostic (2.55e-1)" "unprognostic (5.82e-3)" "unprognostic (9.10e-2)" "unprognostic (3.81e-2)" "unprognostic (1.79e-1)" "unprognostic (6.59e-2)" 147.5 121.5 35.8 47.4 57.3 68.9 83.2 40.0 51.4 61.1 96.9 68.4 51.4 37.0 9.5 108.4 36.5 170.0 35.8 41.2 42.7 105.2 99.3 81.8 33.6 64.5 44.9 125.8 177.1 1007.1 12.0 70.6 49.6 47.6 39.0 14.1 70.8 60.3 50.2 75.7 282.5 48.4 35.8 21.5 104.2 30.4 53.6 39.7 56.7 33.9 78.1 141.3 96.7 94.0 4.1 6.9 4.2 0.4 51.7 12.9 5.9 76.7 159.4 98.4 79.8 12.2 10.6 13.1 11.3 79.8 48.0 2.5 6.8 12.2 72.0 0.5 3.1 0.6 175.7 9.2 298.1 0.7 6.8 77.3 75.4 96.7 124.3 39.3 167.1 2.3 25.6 192.8 35.6 0.6 1.1 3.0 4.8 20.3 8.3 2.4 8.9 1.5 469.5 1.4 2.2 18.6 241.7 0.7 319.7 43.2 0.5 2.1 373.9 28.8 12.3 176.9 17.1 36.2 358.5 40.3 26.7 12.0 39.5 2.2 43.4 170.2 0.7 24.4 1.6 1.9 1.3 0.8 14.1 1.4 1.6 2.0 91.6 3.6 14.5 0.9 2.5 12.6 35.8 57.3 40.0 51.4 41.2 42.7 64.5 44.9 49.6 35.8 53.6 94.0 346.2 38.5 177.8 34.0 68.0 183.3 133.7 277.3 329.0 12.0 87.1 112.0 28.4 88.6 168.6 68.0 35.5 41.0 27.0 132.2 21.5 81.3 9.6 145.8 73.1 232.1 10.7 14.7 68.2 171.2 33.6 88.8 206.4 483.4 271.8 33.9 353.4 21.9 284.2 0.0 225.7 65.1 91.6 181.3 1238.4 7.7 15.2 492.5 268.6 58.1 29.6 4.6 2.1 270.9 377.7 36.2 123.9 15.8 92.4 51.0 789.1 124.3 61.5 29.3 13.1 43.5 102.9 38.1 10.2 348.1 116.2 579.8 46.9 48.9 36.3 123.8 SGK2 ENSG00000101049 "Serum/glucocorticoid regulated kinase 2" Q9HBY8 20 43558968-43588237 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 40.5;kidney: 53.6;liver: 63.2" "Cell type enhanced" "Detected in many" "Distal enterocytes: 76.5;Distal tubular cells: 76.3;Hepatocytes: 32.8;Paneth cells: 21.7;Proximal enterocytes: 23.8;Proximal tubular cells: 25.5" "Cancer enhanced" "Detected in many" "liver cancer: 8.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 20.5;CAPAN-2: 14.2;Hep G2: 18.7;OE19: 61.7;RPTEC TERT1: 25.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA008859, HPA011387" Uncertain Supported Nucleoplasm NA NA "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 21: OE19 - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "HPA008859: AB_2668159, HPA011387: AB_1856744" "unprognostic (1.82e-1)" "unprognostic (1.84e-1)" "unprognostic (4.53e-2)" "unprognostic (2.86e-1)" "unprognostic (6.27e-2)" "unprognostic (2.98e-4)" "unprognostic (2.05e-2)" "unprognostic (1.35e-1)" "unprognostic (4.30e-2)" "unprognostic (2.60e-1)" "unprognostic (1.05e-1)" "unprognostic (5.72e-4)" "unprognostic (4.15e-2)" "unprognostic (1.38e-1)" "unprognostic (2.56e-1)" "unprognostic (3.11e-2)" "prognostic favorable (5.65e-4)" 23.5 1.4 4.9 1.5 14.8 0.5 6.1 12.6 10.5 3.5 0.7 37.7 31.6 1.8 33.8 1.0 3.7 10.0 1.2 6.0 7.7 53.6 63.2 1.0 0.2 18.1 13.3 6.6 16.2 0.5 3.0 0.8 14.3 2.6 40.5 5.6 1.8 2.9 0.4 6.2 20.1 1.6 11.8 1.1 22.8 1.8 13.3 0.3 1.7 0.4 0.3 4.2 3.0 24.5 0.0 20.5 0.3 0.1 0.3 0.0 0.1 0.2 0.0 0.2 0.0 0.6 14.2 0.1 8.7 0.1 0.1 0.2 0.0 0.0 0.2 0.0 0.3 0.4 0.0 18.7 0.4 0.0 0.1 0.0 0.5 0.0 0.0 0.7 0.0 0.4 0.2 0.1 0.0 0.1 0.1 0.5 0.1 61.7 0.0 0.1 0.1 0.0 25.4 4.2 0.2 1.0 0.0 1.2 0.1 0.4 0.0 0.1 0.9 0.0 0.1 0.0 0.0 0.9 0.0 0.0 0.2 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.9 14.8 12.6 10.5 6.0 7.7 18.1 13.3 14.3 11.8 13.3 24.5 0.3 0.0 0.0 4.9 0.2 0.1 0.1 0.2 0.0 0.8 0.3 0.8 4.9 8.6 0.0 11.0 0.0 5.1 0.0 76.5 76.3 6.8 0.3 0.9 0.5 0.6 1.8 0.0 0.7 6.3 1.3 0.4 11.2 2.4 0.0 0.7 0.7 32.8 0.7 6.7 1.3 4.1 0.0 1.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.2 0.0 3.5 20.7 2.5 21.7 0.4 0.0 0.1 23.8 25.5 0.2 0.8 0.0 0.2 0.4 0.1 0.1 0.0 0.1 17.1 0.2 0.0 7.7 0.3 SGK3 "SGK2, SGKL" ENSG00000104205 "Serum/glucocorticoid regulated kinase family member 3" Q96BR1 8 66712734-66862022 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 49.0" "Cell type enhanced" "Detected in many" "Breast glandular cells: 56.0;monocytes: 53.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "T-47d: 28.4" "HPA006699, HPA027146" Supported Approved Nucleoplasm,Vesicles NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 73: Brain - Neuropeptide signaling" "Cluster 6: T47d - Mammary gland" "Cluster 35: Glandular cells - Unknown function" Vesicles Nucleoplasm "HPA006699: , HPA027146: AB_1856745" "prognostic favorable (5.52e-6)" "prognostic favorable (8.28e-4)" "unprognostic (8.52e-3)" "unprognostic (1.10e-2)" "unprognostic (3.75e-1)" "unprognostic (1.37e-2)" "unprognostic (2.32e-1)" "unprognostic (1.69e-3)" "unprognostic (9.51e-2)" "unprognostic (8.86e-3)" "prognostic favorable (9.65e-4)" "unprognostic (1.94e-2)" "unprognostic (8.95e-2)" "unprognostic (4.55e-3)" "unprognostic (1.77e-1)" "unprognostic (1.01e-1)" "unprognostic (5.29e-3)" 5.2 5.3 13.4 9.8 25.7 8.5 24.1 21.3 16.9 10.5 36.0 10.3 8.9 8.0 8.6 7.6 6.9 7.5 5.4 14.6 17.3 14.7 13.6 10.0 7.8 29.4 21.6 9.1 15.6 28.3 6.2 5.7 28.3 7.4 10.3 2.4 7.0 7.1 2.9 13.3 11.3 5.3 19.3 8.9 7.5 9.4 20.9 5.8 17.5 3.5 6.9 5.0 5.7 49.0 14.2 3.7 0.6 2.4 3.9 6.5 7.7 8.1 7.4 4.2 5.1 6.1 8.6 10.2 2.2 7.7 13.6 4.9 7.3 5.5 5.4 5.3 11.7 9.7 2.6 6.7 4.1 8.9 10.5 2.9 3.7 1.7 7.9 4.3 7.4 7.4 1.5 4.6 10.0 2.4 6.2 5.8 1.9 8.5 5.0 11.7 5.3 7.6 6.4 3.3 2.9 2.2 3.4 6.5 14.4 6.0 28.4 16.9 9.0 4.4 3.9 3.9 3.4 6.1 12.8 12.7 4.5 14.2 4.9 21.1 15.0 5.1 8.7 9.9 13.8 4.7 8.8 8.0 13.8 6.4 8.7 7.1 2.0 7.2 5.1 8.9 5.7 9.0 13.4 25.7 21.3 16.9 14.6 17.3 29.4 21.6 28.3 19.3 20.9 49.0 20.7 6.4 28.1 0.0 12.5 13.3 8.1 3.3 8.6 1.7 56.0 30.5 7.6 7.2 8.5 11.0 18.8 9.2 24.9 13.3 15.6 7.0 0.9 16.7 6.6 15.3 16.2 10.3 0.0 18.2 1.4 8.9 6.6 12.3 15.2 11.0 17.5 20.7 22.9 0.0 0.0 9.3 8.2 41.9 14.3 2.2 4.1 42.6 8.8 0.0 53.4 3.8 19.6 0.0 0.0 14.8 8.4 7.9 18.3 9.3 14.0 36.8 15.4 1.7 0.0 5.9 4.2 5.9 13.7 9.9 15.8 4.8 19.4 5.2 10.4 5.3 SGMS1 "MGC17342, MOB, SMS1, TMEM23" ENSG00000198964 "Sphingomyelin synthase 1" Q86VZ5 10 50305586-50625163 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Lipid metabolism, Sphingolipid metabolism" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 153.1;Microglial cells: 229.5;Oligodendrocyte precursor cells: 313.1;Oligodendrocytes: 422.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "K-562: 62.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA045191 Approved Approved "Nucleoplasm,Nucleoli fibrillar center,Golgi apparatus,Cytosol" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 1: K-562 - Erythropoiesis" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "Nucleoli fibrillar center, Golgi apparatus, Cytosol" "HPA045191: AB_10959605" "unprognostic (1.13e-1)" "unprognostic (5.75e-2)" "unprognostic (1.87e-1)" "unprognostic (9.08e-2)" "unprognostic (8.69e-3)" "unprognostic (8.34e-2)" "unprognostic (7.98e-2)" "unprognostic (2.29e-1)" "unprognostic (1.30e-2)" "unprognostic (5.75e-2)" "unprognostic (9.20e-2)" "unprognostic (2.05e-1)" "prognostic favorable (1.95e-7)" "unprognostic (8.38e-2)" "unprognostic (1.95e-1)" "unprognostic (3.31e-1)" "unprognostic (3.05e-1)" 15.8 19.3 19.8 10.7 27.4 24.0 14.5 21.5 20.3 16.9 33.9 10.1 13.5 11.9 19.9 15.3 16.6 15.4 13.2 17.2 23.0 20.2 27.9 21.9 14.9 29.5 24.1 18.6 13.3 52.9 6.4 24.6 28.5 19.5 11.7 20.2 18.0 16.8 9.9 25.3 16.0 15.8 23.6 11.7 14.3 11.3 23.4 12.0 24.7 10.5 14.5 20.9 13.1 41.3 30.2 14.0 4.0 9.0 14.2 18.6 18.8 19.6 19.7 13.5 12.6 11.7 30.3 22.1 11.3 25.9 12.2 18.7 9.5 20.6 14.0 19.4 10.2 32.7 17.9 9.0 16.5 7.5 7.6 12.1 23.6 18.0 21.7 8.7 19.3 7.9 62.6 32.2 14.6 12.7 3.3 4.2 9.2 13.7 13.7 5.5 18.4 8.8 19.7 31.2 6.2 4.9 14.4 14.2 7.5 11.3 21.4 2.7 27.1 14.6 17.8 14.1 14.6 11.0 9.5 6.3 18.2 12.0 12.1 3.4 9.3 28.4 4.6 4.9 10.3 7.0 6.2 6.8 5.2 6.5 8.2 5.4 16.7 10.1 4.0 3.2 15.6 6.3 19.8 27.4 21.5 20.3 17.2 23.0 29.5 24.1 28.5 23.6 23.4 41.3 17.1 44.8 40.0 106.7 19.9 54.4 28.9 15.6 23.9 20.1 15.8 8.9 26.3 10.0 30.0 29.5 4.2 10.9 15.6 6.2 15.6 17.6 17.0 20.9 10.5 19.6 14.9 32.0 153.1 21.6 7.7 19.8 30.5 32.4 20.8 12.1 17.9 16.0 29.0 5.0 117.2 11.1 4.1 46.5 17.6 30.6 16.1 34.5 12.4 229.5 12.4 17.4 10.3 313.1 422.0 10.7 6.4 10.5 13.7 32.3 18.4 9.3 25.1 36.4 0.0 20.5 27.1 12.8 2.3 18.7 83.4 4.9 20.0 11.8 12.4 25.4 SGMS2 "MGC26963, SMS2" ENSG00000164023 "Sphingomyelin synthase 2" Q8NHU3 4 107824563-107915047 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Lipid metabolism, Sphingolipid metabolism" "Kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 126.6;Basal prostatic cells: 167.4;Endometrial ciliated cells: 172.1;Glandular and luminal cells: 147.8;Urothelial cells: 159.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 8 "classical monocyte: 3.7;eosinophil: 2.4;intermediate monocyte: 1.5;myeloid DC: 4.2;non-classical monocyte: 1.4" "Group enriched" "Detected in many" 35 "dendritic cells: 4.2;granulocytes: 2.4;monocytes: 3.7" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA015076 Supported NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 44: Endometrium - Transcription" "HPA015076: AB_1857298" "unprognostic (7.44e-2)" "unprognostic (2.32e-2)" "unprognostic (2.36e-2)" "unprognostic (1.87e-2)" "unprognostic (7.88e-3)" "unprognostic (9.53e-2)" "unprognostic (5.01e-2)" "unprognostic (1.32e-1)" "unprognostic (4.15e-1)" "unprognostic (1.10e-1)" "unprognostic (1.82e-3)" "unprognostic (3.26e-1)" "prognostic favorable (1.37e-4)" "unprognostic (6.18e-2)" "unprognostic (5.63e-2)" "unprognostic (8.71e-2)" "unprognostic (5.22e-3)" 8.6 3.0 5.2 9.0 15.3 4.6 5.2 10.1 7.8 12.7 36.7 12.3 19.5 8.8 4.6 16.4 12.5 39.6 9.1 3.3 6.5 14.5 20.4 27.8 1.1 13.9 14.3 1.1 11.7 3.6 4.7 5.1 13.0 9.6 10.6 0.8 9.2 4.6 2.5 3.6 16.5 29.1 10.2 1.1 13.8 9.6 10.6 0.8 18.0 3.4 2.9 13.9 4.2 21.6 20.8 7.7 1.1 5.8 12.9 29.9 0.4 25.0 18.8 11.6 12.1 3.5 42.1 1.5 9.7 40.0 10.1 7.6 14.5 22.1 20.7 5.9 5.7 0.9 16.5 1.2 14.8 14.2 0.1 10.4 15.1 22.7 27.4 24.2 26.1 0.3 0.2 0.5 18.6 6.9 0.5 0.1 0.7 12.1 8.6 0.5 9.9 2.9 30.7 10.0 2.0 0.1 19.1 26.9 3.3 3.0 14.5 0.4 44.7 13.9 21.9 20.1 11.7 1.4 0.5 0.8 18.7 3.4 5.9 0.0 3.7 2.4 0.0 1.5 0.0 0.0 0.0 0.0 4.2 0.0 0.0 0.0 0.3 0.0 1.4 0.0 0.0 1.0 5.2 15.3 10.1 7.8 3.3 6.5 13.9 14.3 13.0 10.2 10.6 21.6 3.4 86.6 126.6 7.2 1.0 56.0 167.4 12.8 18.2 0.5 20.9 10.4 17.8 28.6 88.0 16.5 0.0 1.0 2.9 32.3 3.9 19.8 71.4 172.1 13.5 10.7 8.9 0.0 8.0 19.5 0.9 26.6 58.1 147.8 10.1 2.8 11.4 25.0 5.5 1.7 10.0 26.0 14.2 22.1 43.0 11.1 2.5 28.2 8.8 1.9 23.3 0.2 2.1 0.5 18.5 37.9 60.5 0.4 0.4 96.9 33.5 12.4 104.0 0.1 0.0 46.1 22.0 0.9 3.1 38.1 72.9 13.8 3.3 0.1 21.8 159.7 SH3RF1 "KIAA1494, POSH, RNF142, SH3MD2" ENSG00000154447 "SH3 domain containing ring finger 1" Q7Z6J0 4 169094259-169270956 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Host-virus interaction, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 146.3;Oligodendrocytes: 213.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 4 "intermediate monocyte: 4.2;myeloid DC: 2.5;non-classical monocyte: 6.7" "Group enriched" "Detected in many" 15 "dendritic cells: 2.5;monocytes: 6.7" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA074783 Approved Supported "Vesicles,Intermediate filaments" No No "Cluster 51: Monocytes - Innate immune response" "Cluster 45: Intestine - Brush border" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 22: Epithelial cell types - Mixed function" Vesicles "Intermediate filaments" "HPA074783: AB_2732268" "unprognostic (4.14e-1)" "unprognostic (4.67e-2)" "unprognostic (1.23e-1)" "unprognostic (7.83e-2)" "unprognostic (1.02e-1)" "unprognostic (1.30e-2)" "unprognostic (1.29e-1)" "unprognostic (2.65e-1)" "unprognostic (8.44e-2)" "unprognostic (9.58e-2)" "unprognostic (4.77e-3)" "unprognostic (7.88e-2)" "prognostic favorable (5.51e-8)" "unprognostic (4.43e-2)" "unprognostic (1.63e-1)" "unprognostic (5.99e-2)" "unprognostic (1.77e-1)" 9.8 3.7 8.7 4.4 10.0 3.4 8.2 7.6 13.1 5.7 5.9 15.1 13.8 4.3 5.7 5.9 5.6 11.9 5.7 18.2 8.6 12.2 8.0 9.4 3.3 8.8 9.7 8.5 10.4 3.7 3.7 7.4 9.4 14.3 13.6 2.4 15.8 8.4 9.4 5.1 13.1 4.0 8.2 3.9 24.7 6.1 9.5 2.0 19.9 10.0 3.2 9.3 4.4 13.0 15.2 12.2 11.0 31.9 11.5 14.3 14.1 40.5 19.7 30.0 13.8 12.5 17.8 0.0 1.9 43.1 8.1 9.8 8.9 16.2 32.4 0.1 5.2 8.7 27.4 6.5 26.0 3.1 0.3 8.5 8.6 25.7 19.9 37.3 18.7 3.3 0.1 0.0 27.8 6.0 3.1 2.9 5.6 19.2 10.5 4.5 3.6 0.6 13.6 11.8 8.3 9.9 10.4 15.7 4.2 4.7 5.2 1.3 17.1 14.2 11.0 23.6 14.7 1.1 0.0 0.1 16.0 3.0 17.3 0.0 1.0 0.0 0.0 4.2 0.0 0.3 0.0 0.0 2.5 0.1 0.0 0.0 0.0 0.2 6.7 0.2 0.0 0.6 8.7 10.0 7.6 13.1 18.2 8.6 8.8 9.7 9.4 8.2 9.5 13.0 28.0 64.1 37.7 146.3 3.4 34.3 48.3 11.9 13.6 3.5 21.1 15.6 11.2 44.3 34.4 27.6 0.0 12.7 0.4 69.3 11.7 42.2 5.5 28.5 14.2 13.0 31.3 2.1 54.9 63.7 22.1 16.5 65.7 46.5 10.2 5.6 11.4 12.4 7.4 0.0 54.9 27.1 12.2 9.3 5.3 3.5 12.2 11.1 3.6 52.5 3.9 11.3 0.0 89.5 213.0 68.4 37.2 12.0 2.4 63.2 28.9 18.4 31.7 1.2 65.7 24.1 36.9 5.4 10.7 9.4 12.6 13.1 1.7 6.5 34.4 72.0 SH3RF2 "FLJ23654, Hepp1, POSHER, PPP1R39, RNF158" ENSG00000156463 "SH3 domain containing ring finger 2" Q8TEC5 5 145936578-146081791 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Protein phosphatase inhibitor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 58.1;skeletal muscle: 42.4;skin 1: 56.8" "Cell type enriched" "Detected in many" 5 "Late spermatids: 7869.1" "Low cancer specificity" "Detected in many" "Group enriched" "Detected in some" 4 "basal ganglia: 6.1;cerebral cortex: 4.1;thalamus: 1.7" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "CACO-2: 70.3;GAMG: 29.8;hTERT-RPE1: 33.5" "Region enriched" "Detected in many" 14 "basal ganglia: 26.7" "Region enhanced" "Detected in many" "basal ganglia: 9.7" "HPA035903, HPA058119" Uncertain Enhanced Nucleoplasm NA Yes "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 31: Skin - Epidermis development" "Cluster 39: CACO-2 - Unknown function" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "HPA035903: AB_10696515, HPA058119: AB_2683611" "unprognostic (8.90e-3)" "unprognostic (2.00e-3)" "unprognostic (5.11e-3)" "unprognostic (1.66e-2)" "unprognostic (1.45e-3)" "unprognostic (1.47e-2)" "unprognostic (9.96e-3)" "unprognostic (8.22e-2)" "unprognostic (3.92e-1)" "unprognostic (7.37e-3)" "unprognostic (2.44e-3)" "unprognostic (1.66e-1)" "unprognostic (2.98e-2)" "unprognostic (5.21e-2)" "unprognostic (1.46e-1)" "unprognostic (2.64e-2)" "unprognostic (4.13e-3)" 1.9 0.9 0.6 2.5 6.1 0.0 4.7 0.0 4.1 7.6 0.2 14.3 16.0 1.1 3.6 34.1 6.1 11.9 58.1 0.9 0.5 0.9 7.0 2.7 0.2 0.0 0.3 0.4 15.4 0.0 1.6 0.1 0.0 2.7 14.3 0.5 12.1 0.6 42.4 56.8 13.7 1.1 0.0 0.0 20.5 6.8 1.7 1.0 6.3 8.8 7.7 1.2 20.6 0.4 21.0 5.7 0.2 1.1 0.0 0.0 0.0 0.2 1.7 4.1 1.7 70.3 19.0 0.0 10.5 0.9 29.8 18.9 0.0 22.4 4.0 0.3 0.3 0.0 8.5 9.5 1.2 0.0 0.0 0.2 11.9 6.4 14.8 33.5 0.2 0.5 0.0 0.0 1.8 0.1 0.0 0.0 1.6 17.3 1.5 0.0 0.2 0.0 8.7 2.0 0.0 0.0 1.2 0.4 0.5 1.0 6.6 0.1 9.8 0.8 17.3 1.5 6.7 0.0 0.0 0.0 10.6 0.0 0.1 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.1 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.6 6.1 0.0 4.1 0.9 0.5 0.0 0.3 0.0 0.0 1.7 0.4 4.1 16.0 2.3 1.6 0.0 55.1 5.4 14.5 38.7 0.4 3.9 3.3 510.0 8.6 6.7 1.8 0.0 0.2 0.2 38.9 0.0 5.7 1511.3 11.9 0.9 9.7 1.2 0.0 10.5 8.7 0.0 15.4 50.4 26.7 1.3 0.1 0.7 8.4 0.2 0.0 2.2 16.1 8.2 0.0 4.9 7869.1 25.7 2.6 8.8 10.3 0.6 1.6 0.0 1.5 0.7 21.4 22.9 34.6 0.6 2.2 26.6 0.9 4.4 0.1 13.1 1.6 6.3 31.4 20.7 70.9 50.0 0.0 0.7 2.9 33.2 6.6 SH3RF3 "FLJ00204, POSH2, SH3MD4" ENSG00000172985 "SH3 domain containing ring finger 3" Q8TEJ3 2 109129205-109504634 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in many" 7 "Astrocytes: 47.0;Excitatory neurons: 108.3;Inhibitory neurons: 160.9;Microglial cells: 164.9;Oligodendrocyte precursor cells: 42.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HHSteC: 19.8;RPMI-8226: 20.5;TIME: 23.2;U-266/84: 28.6" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA044822, HPA048444" Approved Supported Nucleoplasm Yes No "Cluster 47: Non-specific - Unknown function" "Cluster 16: U-266 - Nucleosome" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "HPA044822: AB_2679103, HPA048444: AB_2680396" "unprognostic (1.97e-1)" "unprognostic (8.84e-3)" "unprognostic (8.04e-2)" "unprognostic (1.91e-1)" "unprognostic (2.55e-1)" "unprognostic (1.78e-1)" "unprognostic (8.00e-2)" "unprognostic (1.76e-1)" "unprognostic (2.98e-2)" "prognostic unfavorable (2.33e-4)" "unprognostic (4.57e-2)" "unprognostic (1.95e-1)" "unprognostic (3.54e-2)" "unprognostic (4.94e-2)" "unprognostic (2.72e-1)" "unprognostic (2.79e-2)" "unprognostic (1.39e-2)" 6.1 6.7 4.7 3.0 6.1 0.8 4.3 1.3 6.5 5.5 1.6 5.6 1.1 3.7 0.7 2.8 4.8 4.4 6.0 6.3 3.2 6.8 1.1 7.2 2.1 3.0 4.5 3.2 2.0 0.5 1.9 5.2 2.8 4.7 1.4 0.6 1.6 4.4 5.7 3.1 3.3 3.8 3.1 2.1 2.9 4.2 3.9 3.2 2.5 7.3 1.2 5.5 4.2 3.5 0.0 0.1 0.1 2.2 9.0 6.9 0.0 4.2 12.2 3.1 1.1 1.1 0.0 0.0 3.1 3.1 0.7 0.0 0.2 1.8 1.3 0.0 4.2 0.0 0.2 0.0 19.8 0.1 0.0 12.0 2.9 14.1 6.3 1.8 11.4 2.2 0.0 11.7 7.3 0.0 0.0 6.5 1.1 0.0 12.0 2.6 0.0 20.5 0.0 0.0 0.7 2.5 0.0 0.0 0.4 0.1 0.2 0.0 23.2 4.0 12.0 11.5 5.5 4.0 28.6 0.0 0.0 6.3 5.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 4.7 6.1 1.3 6.5 6.3 3.2 3.0 4.5 2.8 3.1 3.9 3.5 5.3 0.0 0.0 47.0 0.2 1.9 0.4 0.2 1.8 0.5 0.6 0.5 10.7 0.0 0.7 0.0 0.0 0.0 1.5 0.1 0.0 1.1 2.6 9.4 9.6 6.7 1.8 0.0 108.3 0.2 0.2 4.8 0.0 1.1 0.0 0.2 7.5 0.0 4.7 10.1 160.9 0.8 0.0 2.5 1.5 5.2 2.1 1.2 5.4 164.9 0.0 1.7 0.0 42.3 1.9 0.1 0.0 3.0 1.6 0.2 0.0 0.6 2.1 0.0 13.1 3.2 6.8 0.7 9.6 0.8 0.9 0.1 0.5 2.3 0.1 0.0 SHMT1 "CSHMT, MGC15229, MGC24556, SHMT" ENSG00000176974 "Serine hydroxymethyltransferase 1" P34896 17 18327860-18363563 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "One-carbon metabolism" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "kidney: 168.5;liver: 398.7" "Group enriched" "Detected in many" 4 "Hepatocytes: 307.7;Proximal tubular cells: 435.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA023314, HPA078682" Enhanced Supported Nucleoplasm,Cytosol NA NA 1500000 "Cluster 44: Non-specific - Transcription" "Cluster 81: Kidney & Liver - Metabolism" "Cluster 18: U-2197 - ECM organization" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Cytosol Nucleoplasm "HPA023314: AB_1856830, HPA078682: " "unprognostic (4.76e-2)" "unprognostic (1.98e-2)" "unprognostic (5.46e-2)" "unprognostic (3.76e-1)" "unprognostic (2.45e-1)" "unprognostic (8.44e-3)" "prognostic favorable (2.52e-4)" "unprognostic (7.55e-3)" "unprognostic (4.50e-1)" "unprognostic (2.42e-1)" "unprognostic (2.14e-1)" "unprognostic (1.70e-1)" "prognostic favorable (8.54e-6)" "unprognostic (1.70e-2)" "unprognostic (2.66e-1)" "unprognostic (2.57e-3)" "unprognostic (4.04e-2)" 37.5 9.4 8.1 4.0 9.4 9.5 36.3 12.6 9.5 13.6 7.1 17.5 13.8 7.6 4.9 59.2 13.1 7.7 5.7 8.8 8.5 168.5 398.7 10.3 9.0 10.8 9.3 11.7 8.8 85.7 4.1 7.7 10.7 10.1 6.1 3.1 30.0 10.0 18.8 22.6 24.4 3.7 8.0 21.7 13.3 12.8 9.4 21.1 23.5 18.6 17.6 11.5 19.3 16.0 39.6 28.9 5.5 34.5 29.9 15.8 63.0 11.3 10.3 30.8 31.2 22.1 22.5 26.8 27.8 3.6 16.4 18.8 32.4 39.7 24.3 17.3 30.6 13.0 39.9 21.6 7.2 4.4 11.0 21.1 13.6 23.1 7.2 10.9 9.7 32.3 10.0 10.9 11.3 12.4 46.0 13.9 17.4 43.6 5.1 29.7 48.5 34.7 69.3 17.0 24.0 5.3 82.7 14.9 21.4 50.2 64.5 19.4 2.6 5.7 14.0 71.4 17.6 10.7 20.5 7.1 10.3 12.7 16.5 10.2 4.7 5.2 5.3 5.9 8.1 4.4 6.6 5.5 3.5 3.7 6.8 6.4 0.2 8.5 5.2 1.1 11.2 4.3 8.1 9.4 12.6 9.5 8.8 8.5 10.8 9.3 10.7 8.0 9.4 16.0 11.2 12.8 31.0 3.3 10.4 10.3 21.7 16.5 18.8 3.1 22.7 13.8 2.7 42.9 11.2 36.8 4.2 23.7 5.2 8.9 82.2 13.7 10.9 6.2 1.9 7.4 1.2 28.0 5.2 7.7 76.1 8.0 9.2 10.1 8.2 9.9 13.6 307.7 39.6 0.0 4.8 12.9 4.1 36.8 3.5 5.5 5.9 17.2 12.4 9.4 4.4 33.8 5.2 2.0 11.4 5.3 9.7 3.0 20.3 5.9 53.7 435.7 3.5 4.2 19.7 8.1 4.4 30.0 21.4 35.4 10.5 8.5 10.1 4.9 32.2 10.9 SHMT2 SHMT ENSG00000182199 "Serine hydroxymethyltransferase 2" P34897 12 57229573-57234935 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "One-carbon metabolism" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 182.3" "Cell type enhanced" "Detected in many" "Hepatocytes: 182.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RH-30: 2292.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020543, HPA020549" Enhanced Supported Microtubules,Mitochondria NA NA 390000 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 85: Liver - Metabolism" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Mitochondria Microtubules "HPA020543: AB_1856833, HPA020549: AB_1856834" "prognostic unfavorable (8.37e-5)" "unprognostic (1.24e-1)" "unprognostic (1.90e-1)" "unprognostic (2.65e-2)" "unprognostic (1.65e-1)" "unprognostic (4.97e-2)" "unprognostic (1.58e-2)" "unprognostic (9.83e-2)" "unprognostic (1.11e-2)" "unprognostic (2.67e-2)" "unprognostic (4.00e-2)" "unprognostic (3.19e-2)" "prognostic unfavorable (4.84e-8)" "unprognostic (3.05e-1)" "unprognostic (2.30e-1)" "unprognostic (2.72e-1)" "unprognostic (4.74e-2)" 25.4 25.4 18.5 43.3 18.6 41.4 23.8 20.7 22.2 22.5 18.4 32.4 35.5 19.4 18.9 46.5 23.3 20.2 24.2 21.1 20.3 32.4 182.3 23.6 52.2 20.6 20.6 25.8 62.2 15.6 15.8 33.6 21.2 13.8 27.2 13.9 30.7 11.7 36.6 36.4 27.0 27.3 20.1 34.9 32.2 5.1 21.8 36.0 34.7 30.5 58.6 26.4 23.6 23.0 246.9 137.6 123.5 368.0 101.8 152.4 238.1 140.8 237.9 197.0 176.5 200.1 120.4 499.8 217.3 186.5 80.6 167.3 229.4 250.6 108.9 265.0 201.9 199.7 79.6 180.1 680.9 333.1 181.0 191.2 351.9 163.4 538.4 176.0 175.3 283.8 223.0 472.3 141.0 210.6 271.0 217.9 123.1 111.8 223.4 181.2 2292.7 433.6 95.9 151.1 265.4 119.9 73.0 170.1 518.3 48.5 222.9 424.2 108.8 84.6 150.5 96.1 185.0 574.1 338.4 421.4 169.6 320.2 154.0 34.9 41.2 23.3 26.6 50.6 31.5 127.5 46.3 29.4 59.6 137.9 21.1 22.0 2.0 40.1 34.1 20.4 202.8 53.8 18.5 18.6 20.7 22.2 21.1 20.3 20.6 20.6 21.2 20.1 21.8 23.0 9.1 9.6 14.1 4.2 58.2 34.7 23.0 43.5 39.9 7.0 26.5 24.0 12.1 21.5 23.5 3.7 0.0 55.4 11.6 9.6 13.7 45.7 0.4 6.3 22.6 17.1 9.6 53.8 3.7 47.7 52.7 25.5 23.4 10.9 29.2 18.7 22.1 182.8 50.2 8.4 3.2 24.2 34.6 36.0 25.1 0.9 18.0 23.5 39.2 3.7 32.0 45.3 21.6 4.0 2.4 40.1 18.7 16.1 74.4 18.2 15.9 63.6 13.3 6.2 6.6 23.9 40.2 1.9 6.6 52.9 32.5 37.4 21.1 39.5 37.4 23.8 SHPK "CARKL, SHK" ENSG00000197417 Sedoheptulokinase Q9UHJ6 17 3608240-3636250 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Hepatocytes: 19.1;Proximal enterocytes: 18.9;Rod photoreceptor cells: 18.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "HPA024361, HPA064939" Enhanced Approved "Nucleoplasm,Nuclear speckles" NA NA 350000 "Cluster 40: NK-cells - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 39: CACO-2 - Unknown function" "Cluster 45: Enterocytes - Digestion" "Nucleoplasm, Nuclear speckles" "HPA024361: AB_1846030, HPA064939: AB_2685388" "unprognostic (1.75e-2)" "unprognostic (1.51e-2)" "unprognostic (3.53e-2)" "unprognostic (1.23e-2)" "unprognostic (3.57e-3)" "unprognostic (1.54e-2)" "unprognostic (1.95e-2)" "unprognostic (3.01e-2)" "unprognostic (1.56e-1)" "unprognostic (3.64e-2)" "unprognostic (1.08e-2)" "unprognostic (1.42e-1)" "unprognostic (3.82e-2)" "unprognostic (6.75e-2)" "unprognostic (1.55e-1)" "unprognostic (1.05e-1)" "unprognostic (1.12e-1)" 7.4 9.9 3.5 3.9 5.0 4.8 6.9 4.1 4.4 9.8 3.1 6.4 13.5 4.8 2.9 9.4 6.2 3.6 4.5 3.4 3.5 10.2 23.3 4.7 3.9 3.9 4.8 7.5 10.9 8.6 4.5 6.2 4.2 5.7 6.0 7.1 7.0 5.4 3.3 9.7 11.5 3.5 3.0 4.4 8.4 4.2 4.3 4.5 5.5 3.3 5.3 5.6 7.8 8.7 6.7 13.5 14.0 9.1 5.7 5.7 7.8 4.4 4.0 8.5 5.0 23.3 6.2 7.9 9.5 8.6 7.9 12.8 18.8 14.3 6.1 12.8 18.3 8.6 11.6 17.0 6.9 7.6 11.8 9.7 6.8 9.4 6.3 7.2 16.1 6.2 11.6 9.8 8.3 12.0 9.8 5.9 7.0 15.3 8.9 13.3 7.3 12.6 12.0 8.5 4.1 10.7 16.2 14.7 4.6 8.4 13.2 4.4 11.6 12.8 6.1 12.5 10.9 3.3 4.5 5.2 13.9 6.7 6.7 1.5 2.2 2.5 1.9 2.3 2.0 2.1 1.8 1.6 3.0 1.5 3.0 1.9 0.4 3.2 1.8 3.2 1.6 2.5 3.5 5.0 4.1 4.4 3.4 3.5 3.9 4.8 4.2 3.0 4.3 8.7 2.6 0.0 3.2 11.1 2.0 0.0 1.0 0.1 3.4 5.9 3.2 2.3 1.0 4.3 0.8 5.5 16.7 10.0 1.1 9.2 1.9 3.3 0.5 2.6 2.5 2.9 3.5 5.2 4.5 4.7 10.1 3.3 4.6 2.9 0.0 5.0 3.6 19.1 8.4 15.2 5.3 6.0 0.0 2.2 0.4 0.4 4.1 2.2 0.0 8.4 2.7 2.5 1.0 4.0 8.2 5.3 6.7 2.6 2.0 2.2 18.9 8.5 1.0 18.2 0.0 4.8 1.8 0.6 1.2 3.0 0.4 5.6 2.1 16.9 6.5 1.8 SHPRH "bA545I5.2, FLJ90837, KIAA2023" ENSG00000146414 "SNF2 histone linker PHD RING helicase" Q149N8 6 145864245-145964423 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Helicase, Hydrolase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cone photoreceptor cells: 210.6;Oligodendrocytes: 164.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034854, HPA044852" Approved Approved "Nucleoplasm,Nuclear membrane,Cytosol" NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 34: Non-specific - Transcription" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Nuclear membrane" Cytosol "HPA034854: AB_10964488, HPA044852: " "unprognostic (3.10e-2)" "unprognostic (4.46e-2)" "unprognostic (5.61e-3)" "unprognostic (1.53e-2)" "unprognostic (7.40e-3)" "unprognostic (2.20e-2)" "unprognostic (2.63e-1)" "unprognostic (1.83e-1)" "unprognostic (1.36e-1)" "unprognostic (8.66e-3)" "unprognostic (5.03e-1)" "unprognostic (7.90e-2)" "unprognostic (6.01e-3)" "unprognostic (3.29e-2)" "unprognostic (2.70e-1)" "unprognostic (1.13e-1)" "unprognostic (3.01e-1)" 4.9 4.2 3.1 4.7 3.7 4.2 7.2 18.4 5.1 5.4 3.2 4.3 4.2 7.7 6.0 4.3 5.2 4.6 3.5 3.0 2.5 5.5 4.6 4.2 6.9 2.8 2.6 12.2 3.9 6.7 2.0 4.5 4.5 5.5 5.0 16.3 5.8 5.1 4.2 9.7 4.5 5.7 2.5 6.4 5.4 7.6 2.9 7.2 8.4 5.2 5.8 4.3 3.3 5.5 4.2 3.2 15.3 9.1 7.0 7.3 7.2 4.9 3.9 5.9 7.6 7.0 2.9 14.5 5.9 3.7 4.6 7.0 9.5 6.9 7.7 6.5 10.9 14.6 7.6 6.1 5.2 31.2 8.6 5.2 7.8 5.6 8.0 5.8 6.4 10.0 20.3 7.9 5.1 3.7 19.8 11.6 10.3 6.9 5.4 14.1 23.6 5.0 8.0 4.1 12.6 8.8 8.7 7.9 5.4 10.5 4.2 14.6 7.2 3.7 7.0 7.4 5.8 6.4 9.4 17.1 3.9 13.0 6.0 0.7 0.9 1.9 1.7 0.9 1.5 1.5 1.4 1.1 1.1 2.5 1.5 1.3 0.0 1.5 1.0 2.0 1.4 0.5 3.1 3.7 18.4 5.1 3.0 2.5 2.8 2.6 4.5 2.5 2.9 5.5 31.4 28.9 23.4 106.7 31.0 21.2 17.9 14.5 19.4 117.2 21.5 20.3 17.2 20.0 20.7 22.0 210.6 16.1 34.6 9.1 7.9 18.6 20.4 20.9 52.8 26.0 19.2 15.3 131.0 12.9 7.0 25.9 23.9 18.1 13.3 145.7 15.7 20.5 12.0 94.2 140.3 14.7 6.1 21.4 9.8 8.0 50.7 19.8 14.2 93.7 30.6 40.7 36.0 143.7 164.6 15.9 8.8 34.3 23.5 18.8 17.2 7.5 14.9 158.5 72.3 47.1 39.1 83.2 65.0 16.5 19.7 6.6 26.4 61.5 18.0 12.5 SIAH1 hSIAH1 ENSG00000196470 "Siah E3 ubiquitin protein ligase 1" Q8IUQ4 16 48356364-48448402 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters" "Apoptosis, Cell cycle, Differentiation, Spermatogenesis, Ubl conjugation pathway" "Developmental protein, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 4 "Cytotrophoblasts: 187.4;Syncytiotrophoblasts: 746.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB018724 Enhanced Uncertain Nucleoplasm,Mitochondria NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 28: Placenta - Pregnancy" "Cluster 30: Epithelial cell lines - Translation" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" Mitochondria Nucleoplasm "CAB018724: AB_2188865" "unprognostic (7.08e-2)" "unprognostic (1.16e-1)" "unprognostic (4.88e-2)" "unprognostic (1.07e-1)" "unprognostic (2.92e-3)" "unprognostic (1.25e-2)" "unprognostic (7.93e-3)" "unprognostic (1.12e-2)" "unprognostic (9.22e-3)" "unprognostic (3.26e-1)" "unprognostic (8.02e-2)" "unprognostic (7.84e-3)" "unprognostic (7.67e-3)" "unprognostic (4.38e-2)" "unprognostic (4.00e-1)" "unprognostic (9.55e-2)" "unprognostic (1.26e-2)" 23.3 14.1 12.0 10.8 13.9 28.2 22.8 16.2 16.0 19.3 13.3 15.9 16.0 19.4 15.6 14.0 17.4 15.8 15.0 12.3 12.4 14.6 22.6 17.6 14.0 13.6 14.6 19.2 14.1 14.6 10.3 50.1 13.2 16.8 14.6 19.1 16.1 13.8 21.5 22.3 16.2 14.5 12.2 13.4 15.7 23.3 13.5 14.1 17.5 17.3 13.0 14.1 17.1 16.9 15.5 13.7 29.1 26.3 24.5 21.3 29.6 14.2 19.2 20.6 10.1 10.5 19.7 20.1 15.3 18.0 14.4 17.6 20.3 20.7 25.3 8.1 16.4 10.8 10.6 27.8 34.2 10.7 15.8 25.8 36.5 12.1 27.9 23.1 17.5 18.5 17.7 18.4 17.0 10.6 29.1 21.9 35.5 17.1 21.0 33.3 43.7 21.3 19.5 19.3 33.1 29.3 42.0 20.9 37.7 24.8 13.3 24.4 18.8 22.0 19.8 12.0 15.4 24.0 10.7 36.8 16.3 13.1 20.2 13.7 8.1 35.4 4.1 3.6 4.5 20.4 4.4 6.3 13.0 19.2 8.7 6.6 4.7 8.7 2.2 12.5 2.5 5.8 12.0 13.9 16.2 16.0 12.3 12.4 13.6 14.6 13.2 12.2 13.5 16.9 43.0 12.8 9.7 8.8 24.7 85.7 55.7 45.0 71.2 22.3 43.5 32.0 13.3 20.0 20.5 16.5 8.4 187.4 15.3 27.3 31.3 24.5 70.5 21.9 26.7 35.7 22.6 27.0 20.1 22.7 34.0 42.5 21.9 34.5 4.5 37.8 33.9 23.6 34.3 35.3 20.9 17.8 40.7 20.3 99.2 71.3 22.7 31.1 49.8 23.4 27.0 38.3 4.1 25.6 40.2 22.3 18.2 19.5 17.9 49.7 23.5 28.9 17.0 18.6 19.7 36.2 34.4 70.0 51.0 67.7 75.7 746.2 17.3 17.4 20.6 50.8 SIAH2 ENSG00000181788 "Siah E3 ubiquitin protein ligase 2" O43255 3 150741125-150763477 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters" "Apoptosis, Biological rhythms, Cell cycle, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Erythroid cells: 226.7;Syncytiotrophoblasts: 389.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA061293, CAB069930" Approved Approved Nucleoplasm,Vesicles NA NA "Cluster 46: Basophils - DNA binding" "Cluster 85: Liver - Metabolism" "Cluster 29: U-266 - Adaptive immune response" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" Nucleoplasm Vesicles "CAB069930: AB_1217916, HPA061293: AB_2684470" "prognostic favorable (1.17e-4)" "unprognostic (1.04e-3)" "unprognostic (3.83e-2)" "unprognostic (9.15e-2)" "unprognostic (1.69e-1)" "unprognostic (6.91e-2)" "unprognostic (1.86e-2)" "unprognostic (5.68e-3)" "unprognostic (6.26e-2)" "unprognostic (1.95e-2)" "prognostic unfavorable (8.21e-5)" "unprognostic (1.34e-1)" "unprognostic (1.38e-1)" "unprognostic (2.38e-2)" "unprognostic (5.56e-1)" "unprognostic (1.66e-1)" "unprognostic (4.69e-2)" 15.8 78.6 16.4 20.8 19.0 44.7 17.1 17.4 24.9 48.0 17.3 17.7 13.5 33.4 18.6 46.1 27.2 14.3 16.2 16.9 16.7 12.1 61.2 13.2 35.8 15.8 15.5 24.4 20.9 15.9 11.0 43.1 17.9 19.4 15.4 7.8 16.4 34.7 12.3 30.4 12.9 29.4 15.5 24.4 17.9 8.0 16.5 25.1 8.0 12.8 45.3 23.5 39.6 26.0 54.0 13.4 10.5 20.1 35.4 26.4 41.7 22.9 26.5 27.3 32.4 28.4 24.7 31.3 31.0 24.1 22.8 31.4 28.6 20.7 25.6 24.4 19.5 61.5 16.0 94.7 50.4 34.3 16.0 24.1 47.0 16.3 36.9 21.7 21.5 60.2 15.5 110.8 17.4 66.4 58.7 17.4 33.1 52.3 26.0 44.0 22.7 110.4 17.4 17.9 38.4 19.1 17.4 15.4 39.8 23.8 99.5 50.0 15.0 17.7 15.8 40.1 31.0 130.6 55.9 42.0 17.6 48.6 9.2 8.9 2.2 8.6 1.6 1.2 2.5 2.2 2.8 2.5 2.0 2.2 1.4 1.4 4.7 1.4 1.3 2.6 1.6 0.9 16.4 19.0 17.4 24.9 16.9 16.7 15.8 15.5 17.9 15.5 16.5 26.0 15.9 6.4 4.8 6.8 99.0 146.7 82.3 11.8 153.1 47.0 32.3 22.2 17.8 25.8 11.7 22.0 37.5 192.0 62.6 30.2 13.7 8.5 3.4 56.0 29.2 22.5 38.3 226.7 14.1 6.6 23.4 28.8 44.4 96.5 10.2 18.7 20.7 54.4 32.6 35.3 11.0 39.9 14.2 115.5 102.7 2.1 44.1 70.4 44.4 14.0 22.7 32.7 32.0 5.0 11.5 10.5 17.9 30.9 128.7 56.7 20.7 17.9 16.5 2.8 13.1 11.8 29.9 0.7 10.8 154.1 142.4 389.4 86.1 28.6 34.5 81.8 SIK1 "msk, SNF1LK" ENSG00000142178 "Salt inducible kinase 1" P57059 21 43414483-43427131 "Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Biological rhythms, Cell cycle, Differentiation" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Epilepsy, Tumor suppressor" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skin 1: 88.0" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 302.0;Basal respiratory cells: 123.5;Langerhans cells: 141.9;Suprabasal keratinocytes: 422.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HBEC3-KT: 35.3;HeLa: 63.1;hTCEpi: 45.4;LHCN-M2: 45.5;U-266/84: 37.7" "Low region specificity" "Detected in all" "CAB023801, HPA038211, HPA078064" Approved Approved Nucleoplasm,Vesicles NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 61: Skin - Cornification" "Cluster 20: HeLa - Mitochondria" "Cluster 28: Keratinocytes - Keratinization" Nucleoplasm Vesicles "CAB023801: , HPA038211: AB_2675894, HPA078064: " "unprognostic (4.06e-2)" "unprognostic (9.38e-2)" "unprognostic (3.31e-3)" "unprognostic (3.00e-1)" "unprognostic (5.02e-2)" "unprognostic (7.97e-3)" "unprognostic (1.51e-1)" "unprognostic (7.30e-3)" "unprognostic (2.35e-3)" "unprognostic (4.97e-2)" "unprognostic (1.89e-2)" "unprognostic (1.30e-1)" "unprognostic (3.89e-1)" "unprognostic (9.94e-3)" "unprognostic (3.88e-2)" "unprognostic (2.89e-1)" "unprognostic (1.82e-1)" 24.5 8.3 0.7 6.2 0.4 10.5 19.5 0.5 1.8 17.5 0.8 7.0 0.4 4.4 0.0 18.5 18.6 15.1 16.0 0.3 1.1 5.1 20.9 12.7 4.3 1.0 1.0 26.9 11.8 5.9 12.5 12.5 0.8 9.2 0.7 8.5 12.1 13.3 13.0 88.0 5.4 5.3 0.0 7.2 12.2 3.0 0.7 11.0 6.2 1.3 4.6 16.9 14.4 0.5 1.2 3.4 4.3 0.1 0.3 1.6 1.7 2.0 0.7 3.5 2.7 5.1 0.1 5.4 1.5 0.4 19.8 23.6 3.5 35.3 2.0 0.3 1.1 1.6 63.1 2.0 4.8 1.7 0.2 2.1 45.4 0.9 10.7 20.7 0.7 0.1 0.2 0.2 45.5 0.3 0.9 3.9 1.9 0.0 3.4 0.1 0.8 5.7 4.0 13.3 0.1 0.0 24.2 4.0 0.8 0.7 2.3 0.6 8.1 0.9 4.2 0.4 0.1 9.5 37.7 1.0 10.0 4.6 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.7 0.4 0.5 1.8 0.3 1.1 1.0 1.0 0.8 0.0 0.7 0.5 23.7 28.9 77.3 0.0 18.4 302.0 0.8 123.5 26.7 0.3 8.6 6.3 11.7 7.2 68.4 12.9 0.0 0.8 13.4 16.4 0.0 3.2 0.0 23.2 4.8 18.4 27.6 0.0 0.0 2.1 1.3 11.1 15.3 29.1 19.6 2.3 4.2 7.7 1.7 0.0 0.0 16.5 85.5 3.8 141.9 0.1 0.0 10.1 96.0 0.0 1.6 1.3 0.0 0.0 0.0 7.3 24.3 0.0 36.3 0.5 23.8 0.2 50.7 0.2 0.0 2.4 27.4 0.1 0.4 35.1 422.7 2.5 16.4 0.8 20.3 1.2 SIK1B ENSG00000275993 "Salt inducible kinase 1B (putative)" A0A0B4J2F2 21 6111131-6123778 "Enzymes, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skin 1: 243.9" "Cell type enhanced" "Detected in some" "Adipocytes: 11.9;Alveolar cells type 1: 25.6;Alveolar cells type 2: 27.2;Endometrial ciliated cells: 17.1;Glandular and luminal cells: 30.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "plasmacytoid DC: 1.8" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "HeLa: 95.3;hTERT-RPE1: 117.7;Karpas-707: 120.6;LHCN-M2: 83.0;SiHa: 87.2" "HPA038211, HPA078064" Uncertain Approved Nucleoplasm,Vesicles NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 31: Skin - Epidermis development" "Cluster 20: HeLa - Mitochondria" "Cluster 44: Endometrium - Transcription" Nucleoplasm Vesicles "HPA038211: AB_2675894, HPA078064: " "unprognostic (2.09e-2)" "unprognostic (1.01e-1)" "unprognostic (2.57e-2)" "unprognostic (8.85e-2)" "unprognostic (3.32e-2)" "unprognostic (2.44e-1)" "unprognostic (6.58e-3)" "unprognostic (2.62e-2)" "unprognostic (6.56e-2)" "unprognostic (3.15e-2)" "unprognostic (5.52e-3)" "unprognostic (1.01e-2)" "unprognostic (9.09e-2)" "unprognostic (2.88e-2)" "unprognostic (2.41e-1)" "unprognostic (2.69e-3)" "unprognostic (7.41e-2)" 67.6 52.0 6.5 16.1 5.6 42.4 53.5 5.3 12.3 21.8 7.4 22.2 7.6 16.2 0.4 32.0 31.0 30.4 49.9 6.1 11.2 21.8 71.2 38.1 9.8 10.7 8.0 93.5 47.0 8.0 39.5 14.2 8.3 33.5 12.3 20.9 41.5 41.6 40.1 243.9 17.4 10.5 6.2 18.0 37.5 7.3 7.1 8.2 17.9 4.3 4.7 44.3 46.7 5.7 9.5 47.5 3.5 3.0 0.7 0.4 8.3 1.1 0.6 1.7 1.0 53.3 7.0 3.2 1.4 0.2 7.1 0.8 5.5 0.0 0.6 8.9 1.7 7.4 95.3 10.3 3.1 1.2 0.7 1.2 39.6 4.8 26.5 117.7 2.0 1.5 3.0 120.6 83.0 4.7 0.9 2.3 4.9 8.8 5.1 2.0 21.1 14.3 4.6 16.4 4.4 2.1 87.2 5.5 5.0 2.3 0.9 4.1 2.3 1.4 4.4 2.0 19.9 15.9 37.7 1.6 12.6 3.0 5.6 0.0 0.0 0.0 0.0 0.2 0.1 0.5 0.0 0.0 0.2 0.5 0.0 0.0 0.0 0.1 0.6 1.8 0.0 0.0 6.5 5.6 5.3 12.3 6.1 11.2 10.7 8.0 8.3 6.2 7.1 5.7 11.9 25.6 27.2 0.0 2.6 0.0 0.0 0.0 0.0 0.0 4.0 2.7 0.0 0.0 3.7 1.8 0.0 0.7 4.1 0.0 0.0 0.5 0.0 17.1 3.4 1.4 0.0 0.0 0.0 0.2 0.9 1.5 0.0 30.0 6.3 1.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 3.1 0.0 0.0 0.2 8.7 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 2.5 2.4 0.0 0.0 0.0 SIK2 "DKFZp434K1115, KIAA0781, LOH11CR1I, QIK, SNF1LK2" ENSG00000170145 "Salt inducible kinase 2" Q9H0K1 11 111602449-111730855 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 113.3;Excitatory neurons: 217.6;Inhibitory neurons: 132.4;Oligodendrocytes: 191.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in all" "ASC diff: 50.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016026, HPA071049" Approved Approved "Nucleoplasm,Nuclear speckles,Vesicles,Intermediate filaments,Cytosol" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Nucleoplasm, Vesicles" "Nuclear speckles, Intermediate filaments, Cytosol" "HPA016026: AB_1857321, HPA071049: " "unprognostic (2.35e-1)" "unprognostic (1.10e-1)" "unprognostic (1.08e-1)" "unprognostic (1.10e-2)" "unprognostic (1.59e-2)" "unprognostic (4.81e-2)" "prognostic favorable (4.93e-4)" "unprognostic (6.41e-2)" "unprognostic (1.87e-1)" "unprognostic (1.40e-2)" "unprognostic (3.72e-3)" "unprognostic (9.27e-2)" "prognostic favorable (1.17e-9)" "unprognostic (1.23e-1)" "unprognostic (2.79e-1)" "unprognostic (2.82e-3)" "unprognostic (2.13e-2)" 29.7 9.3 9.2 5.3 12.4 3.1 20.7 7.9 11.1 7.6 11.0 7.9 5.9 7.3 5.0 5.9 8.1 10.0 12.3 9.5 14.7 11.4 22.7 11.7 4.4 11.9 11.9 14.9 31.8 21.3 16.6 5.8 10.6 6.7 6.2 30.7 13.8 6.2 33.1 8.9 7.5 5.9 5.5 4.6 17.6 3.0 9.3 5.4 8.7 23.2 4.3 7.7 6.1 11.6 9.2 6.0 10.3 11.1 50.3 14.8 6.1 7.9 11.2 5.9 6.7 20.5 9.6 7.2 10.7 9.2 6.9 12.7 8.2 5.9 7.6 5.4 3.4 7.9 5.2 10.1 10.9 7.7 4.9 14.5 8.6 8.7 11.1 11.7 7.1 7.1 7.4 10.3 9.4 4.3 8.0 7.0 3.5 7.6 5.9 10.6 11.0 8.7 13.1 8.2 4.8 11.3 11.6 4.7 4.5 9.4 11.5 6.2 9.9 12.9 7.7 8.3 10.9 2.9 2.4 14.8 4.2 10.6 8.8 0.3 0.7 0.6 0.7 0.7 0.3 0.4 0.5 0.5 0.6 0.4 0.2 0.4 0.3 0.5 0.6 0.3 0.5 0.5 9.2 12.4 7.9 11.1 9.5 14.7 11.9 11.9 10.6 5.5 9.3 11.6 22.1 19.2 24.8 113.3 14.1 14.7 6.2 5.2 18.2 15.7 10.5 9.9 21.3 27.1 10.0 16.5 66.7 4.4 11.4 15.6 5.9 10.4 16.5 27.7 14.9 18.8 18.0 12.4 217.6 7.9 4.6 20.1 27.5 45.3 9.5 24.3 9.3 38.7 5.4 32.0 132.4 11.3 4.1 12.4 16.9 14.1 11.5 13.3 19.6 73.1 6.0 14.5 4.1 86.0 191.9 8.4 10.3 14.7 8.9 6.9 8.3 23.1 13.4 60.9 0.0 19.1 19.0 3.9 6.4 10.3 11.9 5.2 12.6 5.0 11.5 7.1 SIK3 "FLJ12240, KIAA0999, L19, QSK" ENSG00000160584 "SIK family kinase 3" Q9Y2K2 11 116843402-117098437 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 375.5;Excitatory neurons: 384.4;Inhibitory neurons: 399.6;Oligodendrocyte precursor cells: 457.9;Oligodendrocytes: 1679.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045245, HPA048161" Enhanced Enhanced Nucleoplasm NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 36: HEL - Hemostasis" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "HPA045245: AB_2679270, HPA048161: AB_2680293" "unprognostic (3.19e-2)" "unprognostic (3.31e-1)" "unprognostic (2.78e-2)" "unprognostic (8.21e-2)" "unprognostic (1.31e-1)" "unprognostic (2.30e-2)" "unprognostic (2.73e-1)" "unprognostic (2.33e-2)" "unprognostic (7.63e-2)" "unprognostic (2.46e-2)" "unprognostic (1.28e-3)" "unprognostic (1.89e-1)" "prognostic favorable (1.12e-5)" "unprognostic (1.82e-1)" "unprognostic (6.85e-2)" "unprognostic (1.02e-2)" "unprognostic (3.28e-2)" 10.1 7.2 19.3 11.4 36.6 12.7 9.2 15.0 34.3 9.6 0.0 11.7 8.5 12.6 7.2 10.4 12.4 9.8 12.8 19.7 19.4 10.3 13.8 9.7 9.9 22.0 23.1 16.5 15.4 17.7 10.0 12.1 22.5 8.2 8.8 19.1 9.8 11.3 19.5 7.5 8.7 14.1 11.5 11.8 9.7 21.4 36.1 12.3 17.1 14.4 10.4 10.1 7.5 41.1 11.8 8.9 13.9 14.7 11.7 12.6 22.2 8.8 15.7 6.8 7.6 21.8 13.3 13.9 14.0 16.3 15.0 18.1 11.6 12.7 9.4 38.5 7.4 31.2 9.7 13.6 10.9 11.2 11.8 13.9 7.2 14.5 23.3 8.7 9.2 9.0 15.2 10.1 9.4 4.0 10.2 12.1 7.7 8.0 6.6 12.9 8.0 11.1 9.3 2.2 13.5 10.8 23.7 10.3 4.4 10.5 6.8 11.8 10.6 8.3 10.4 14.0 8.9 7.1 5.6 17.5 7.7 18.2 11.4 2.0 0.4 0.0 0.3 0.5 0.5 0.1 0.3 0.1 0.6 1.0 0.0 0.0 0.9 0.6 1.5 0.0 0.0 0.2 19.3 36.6 15.0 34.3 19.7 19.4 22.0 23.1 22.5 11.5 36.1 41.1 25.8 9.6 22.1 375.5 34.9 26.5 26.0 6.8 7.4 42.6 26.1 21.5 22.2 10.0 12.4 5.5 112.6 8.7 47.3 12.5 5.9 7.6 89.2 64.4 27.9 20.4 17.3 12.4 384.4 7.3 2.8 22.1 12.8 71.5 17.2 37.4 17.2 26.3 7.7 47.1 399.6 11.1 6.1 21.7 45.1 214.9 10.2 31.4 16.0 161.1 25.6 36.3 12.3 457.9 1679.9 9.2 8.2 14.3 28.1 22.0 9.7 6.9 20.5 63.9 0.0 35.0 23.2 18.0 14.8 7.4 24.3 29.7 44.2 14.8 11.4 30.0 SIRT1 SIR2L1 ENSG00000096717 "Sirtuin 1" Q96EB6 10 67884656-67918390 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Biological rhythms, Differentiation, Host-virus interaction, Myogenesis, Transcription, Transcription regulation" "Developmental protein, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in many" 5 "Early spermatids: 292.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB003855, HPA006295, HPA052351" Approved Supported "Nucleoplasm,Nucleoli fibrillar center,Mitochondria,Cytosol" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 23: Testis - Cell cycle regulation" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "Nucleoli fibrillar center, Mitochondria, Cytosol" "CAB003855: AB_365497, HPA006295: AB_1079975, HPA052351: AB_2681796" "unprognostic (1.55e-1)" "unprognostic (2.78e-1)" "unprognostic (9.13e-2)" "unprognostic (1.05e-1)" "unprognostic (1.91e-1)" "unprognostic (2.05e-2)" "unprognostic (2.48e-1)" "unprognostic (4.95e-2)" "unprognostic (1.41e-1)" "unprognostic (4.64e-2)" "unprognostic (1.72e-1)" "unprognostic (9.61e-2)" "unprognostic (2.18e-2)" "unprognostic (2.83e-2)" "unprognostic (9.67e-2)" "unprognostic (1.12e-1)" "unprognostic (1.39e-1)" 16.4 30.2 8.9 11.0 10.4 19.8 17.5 15.6 11.9 17.1 7.8 12.5 9.2 18.5 11.9 10.9 11.9 14.0 10.6 8.5 9.9 13.4 17.3 12.6 17.7 9.3 9.2 25.1 12.1 14.0 6.9 12.7 10.0 14.0 12.0 13.5 9.9 11.2 14.6 9.6 9.7 13.7 8.8 14.3 10.3 26.8 9.4 19.2 14.7 18.5 15.1 15.5 9.5 12.9 15.1 16.8 26.2 29.4 24.4 18.7 16.3 20.4 21.0 27.4 24.3 18.7 12.6 31.4 10.8 13.7 17.1 11.7 32.8 6.9 29.3 16.9 19.0 16.7 12.1 14.7 22.3 18.1 12.3 17.3 16.2 16.6 28.3 29.4 11.2 17.6 21.6 16.7 20.3 12.1 17.0 25.0 32.5 9.6 26.6 30.3 20.6 12.4 13.1 9.1 16.8 23.0 37.4 24.4 26.8 22.5 17.7 16.6 9.4 21.2 19.8 19.0 20.1 13.9 17.7 61.8 10.9 27.2 8.9 1.3 0.8 1.1 1.1 1.0 1.6 1.8 1.2 1.5 1.3 1.0 2.2 1.3 1.0 1.2 1.3 1.2 1.0 0.6 8.9 10.4 15.6 11.9 8.5 9.9 9.3 9.2 10.0 8.8 9.4 12.9 35.7 19.2 7.4 17.0 27.6 39.1 20.9 7.2 22.8 12.5 48.3 33.4 34.8 11.5 8.7 5.5 27.1 7.1 42.5 31.2 5.9 4.3 292.2 38.4 26.2 20.6 42.9 10.3 16.0 5.6 5.4 28.0 23.4 57.1 12.0 14.8 15.4 15.8 9.1 11.8 18.4 21.0 10.2 23.4 28.7 45.6 17.7 34.1 16.0 30.9 14.8 7.1 9.2 18.6 30.7 6.2 20.6 19.5 15.8 26.0 11.2 8.4 4.1 14.0 0.0 43.4 28.8 24.2 16.3 21.1 47.5 12.4 29.1 8.9 18.7 17.2 SIRT2 SIR2L ENSG00000068903 "Sirtuin 2" Q8IXJ6 19 38878555-38899862 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Autophagy, Cell cycle, Cell division, Differentiation, Immunity, Innate immunity, Meiosis, Mitosis, Neurogenesis, Transcription, Transcription regulation" Transferase "Cancer-related genes, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 302.1;tongue: 218.2" "Cell type enhanced" "Detected in all" "Early spermatids: 173.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004573, HPA011165" Approved Supported Nucleoplasm,Nucleoli,Cytosol NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 80: Striated muscle - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 29: Early spermatids - Spermatogenesis" "Nucleoli, Cytosol" Nucleoplasm "CAB004573: AB_2188600, HPA011165: AB_1856900" "unprognostic (2.15e-2)" "unprognostic (2.24e-2)" "unprognostic (2.88e-1)" "prognostic unfavorable (7.20e-7)" "unprognostic (3.75e-3)" "unprognostic (1.28e-2)" "unprognostic (2.85e-2)" "unprognostic (2.44e-3)" "unprognostic (2.73e-1)" "unprognostic (4.83e-2)" "unprognostic (2.97e-3)" "unprognostic (1.02e-1)" "unprognostic (1.90e-1)" "unprognostic (3.60e-2)" "unprognostic (1.19e-1)" "unprognostic (8.73e-2)" "unprognostic (1.70e-1)" 43.2 44.0 101.6 11.5 137.5 17.4 39.7 141.1 123.0 41.5 79.4 49.2 12.6 37.2 10.4 42.5 37.2 15.0 76.9 100.7 111.2 35.9 51.5 38.2 13.7 151.0 129.6 49.0 33.4 18.2 31.2 10.5 144.7 32.7 10.2 11.9 41.5 14.9 302.1 48.8 32.4 18.3 121.3 40.1 41.4 43.5 127.6 13.1 34.5 218.2 13.0 41.3 37.8 173.5 16.1 9.8 8.4 20.6 46.7 31.8 5.8 11.3 20.2 17.8 22.7 17.1 10.2 5.4 23.7 21.3 13.2 8.3 14.6 25.1 10.9 25.2 15.6 10.1 10.9 10.9 33.0 7.0 22.4 33.5 29.7 14.4 16.9 21.4 31.9 17.7 10.1 42.0 28.2 8.9 15.4 6.2 1.2 27.6 13.6 19.9 22.8 15.3 14.8 14.9 20.7 9.0 12.9 17.8 13.0 7.0 8.0 19.2 28.9 24.0 5.1 37.2 17.0 16.9 8.8 12.6 18.1 19.0 22.0 48.9 54.7 59.8 44.9 69.1 28.5 24.9 21.9 31.0 42.9 28.9 14.3 23.6 42.7 36.5 56.7 44.0 33.1 51.9 101.6 137.5 141.1 123.0 100.7 111.2 151.0 129.6 144.7 121.3 127.6 173.5 39.5 16.0 19.4 26.1 21.0 51.6 30.3 35.1 35.3 29.7 28.8 29.7 42.1 14.3 27.2 12.9 35.5 36.5 90.8 28.4 37.2 29.0 173.0 24.7 15.4 31.1 17.5 27.1 31.2 17.6 15.2 30.3 44.9 26.5 25.4 29.5 28.5 19.7 66.3 30.3 27.2 24.1 97.6 38.3 51.7 74.8 31.1 37.1 46.2 11.2 20.0 22.6 85.5 76.4 110.8 26.5 23.9 41.0 39.7 14.9 54.0 38.8 30.1 28.2 19.7 113.5 27.9 15.3 7.2 30.1 60.1 42.3 45.8 31.3 18.2 21.5 SIRT3 SIR2L3 ENSG00000142082 "Sirtuin 3" Q9NTG7 11 215030-236931 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026809, CAB037142" Approved NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 39: Non-specific - Mitochondria" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 59: Non-specific - Transcription" "CAB037142: AB_1079982, HPA026809: AB_10601160" "unprognostic (1.76e-2)" "unprognostic (2.69e-1)" "unprognostic (2.04e-1)" "prognostic favorable (8.51e-5)" "unprognostic (1.52e-3)" "unprognostic (2.65e-1)" "unprognostic (3.45e-2)" "unprognostic (5.52e-2)" "unprognostic (8.64e-2)" "unprognostic (1.31e-1)" "prognostic favorable (4.45e-4)" "unprognostic (2.06e-1)" "prognostic favorable (4.85e-9)" "unprognostic (1.04e-1)" "unprognostic (5.53e-2)" "unprognostic (3.45e-1)" "unprognostic (3.75e-2)" 11.1 13.8 24.5 10.4 28.8 11.8 18.6 19.7 28.8 14.3 26.1 13.9 13.3 12.6 40.1 9.9 14.4 7.6 24.4 25.1 20.8 17.2 25.8 10.3 13.8 19.0 20.4 18.3 18.0 11.2 28.0 5.8 18.4 16.7 14.2 26.8 12.6 12.4 27.3 20.2 14.6 9.7 19.0 14.7 13.5 25.2 21.6 6.8 15.7 19.9 14.9 11.5 11.1 24.0 9.7 11.1 16.7 17.7 19.1 24.1 8.0 13.6 11.0 10.1 7.9 11.5 22.8 5.9 6.2 8.5 9.8 18.6 8.2 7.4 9.8 11.2 12.7 7.4 15.7 12.6 8.4 9.7 17.3 17.8 14.1 10.2 10.9 17.3 6.7 11.1 15.3 11.0 4.6 10.8 4.0 15.0 7.5 8.5 13.2 10.8 13.2 9.8 10.2 6.6 9.3 7.5 11.5 16.7 6.4 10.8 11.9 2.2 9.3 11.4 5.4 3.2 4.1 19.4 17.3 8.4 12.4 7.7 5.9 0.1 3.1 3.1 3.6 2.5 3.8 5.3 3.3 4.1 2.8 4.3 6.0 4.9 3.1 8.1 6.6 4.8 4.0 2.7 24.5 28.8 19.7 28.8 25.1 20.8 19.0 20.4 18.4 19.0 21.6 24.0 6.0 3.2 6.5 17.0 10.4 5.0 7.0 13.1 12.5 7.4 16.0 15.5 23.4 14.3 7.4 5.5 8.4 12.6 7.2 7.2 33.2 7.5 22.0 7.4 5.8 6.7 6.0 14.3 19.2 5.8 10.3 8.6 11.7 4.6 10.2 8.4 7.5 18.3 8.8 10.1 18.3 8.1 10.2 5.5 3.3 21.0 9.0 6.4 10.6 8.4 3.5 13.5 5.2 9.0 11.6 5.1 9.3 9.1 14.6 5.5 14.3 18.9 9.0 9.5 0.0 7.3 6.5 25.5 9.6 9.9 4.1 6.8 8.4 14.2 11.2 4.0 SIRT4 SIR2L4 ENSG00000089163 "Sirtuin 4" Q9Y6E7 12 120302316-120313249 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "DNA damage" Transferase "Cancer-related genes, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Early spermatids: 29.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "ASC diff: 5.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029691, HPA029692" Enhanced NA NA "Cluster 10: Basophils - Unknown function" "Cluster 54: Non-specific - Microtubule organization" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 23: Spermatids - Flagellum & Golgi organization" "HPA029691: AB_10600118, HPA029692: AB_10611520" "unprognostic (2.62e-2)" "unprognostic (7.08e-2)" "unprognostic (4.46e-3)" "unprognostic (1.09e-1)" "unprognostic (1.51e-1)" "unprognostic (2.35e-2)" "unprognostic (2.37e-2)" "unprognostic (4.53e-2)" "unprognostic (1.25e-1)" "unprognostic (4.49e-2)" "unprognostic (1.56e-3)" "unprognostic (1.54e-1)" "prognostic favorable (1.75e-4)" "unprognostic (4.97e-2)" "unprognostic (2.11e-1)" "unprognostic (9.74e-3)" "unprognostic (2.31e-1)" 0.9 3.9 2.9 1.0 2.6 0.3 1.1 3.7 3.2 1.9 3.1 2.8 3.5 2.0 0.8 1.4 1.4 1.2 4.5 2.8 2.5 3.2 3.9 1.6 1.4 2.8 2.5 2.5 1.9 2.8 0.9 0.9 2.8 1.3 1.0 3.7 3.0 1.5 9.8 3.1 1.6 1.8 2.3 1.5 2.2 6.2 2.6 2.2 1.8 7.2 1.0 1.5 1.3 2.9 0.6 1.4 1.9 0.9 5.9 1.9 0.9 1.4 1.6 1.1 2.9 1.5 0.9 1.0 1.6 0.8 1.5 0.3 1.9 0.7 1.9 2.0 2.5 0.0 0.3 1.2 1.4 1.1 0.5 1.7 1.6 0.6 0.4 3.2 1.5 2.8 2.0 0.1 1.7 0.8 1.9 1.6 1.1 0.4 1.1 2.3 3.5 1.0 1.6 0.1 1.9 1.6 1.0 0.1 0.9 3.2 2.3 0.4 0.2 0.9 1.5 0.8 0.3 2.3 2.1 0.3 0.9 0.6 1.4 6.7 1.4 0.2 3.8 0.6 5.8 2.7 2.5 3.1 0.8 3.5 4.4 3.9 0.0 2.5 0.1 3.8 0.2 1.2 2.9 2.6 3.7 3.2 2.8 2.5 2.8 2.5 2.8 2.3 2.6 2.9 1.3 6.4 2.0 3.6 2.3 0.4 0.8 0.6 1.2 0.8 1.3 2.4 4.5 0.0 2.4 0.0 2.1 1.2 2.2 0.1 7.9 1.7 29.7 1.2 1.5 0.4 0.0 0.8 5.5 1.1 1.0 1.2 1.1 1.0 0.0 2.8 0.4 1.4 0.7 5.0 7.0 0.9 0.0 0.0 0.6 4.0 1.2 0.4 0.0 1.0 0.0 1.8 0.0 3.5 2.5 0.6 2.9 2.2 0.7 0.4 4.5 6.1 0.4 2.9 0.0 1.1 1.5 6.3 0.9 1.5 1.4 0.8 1.3 6.3 0.9 0.1 SIRT6 ENSG00000077463 "Sirtuin 6" Q8N6T7 19 4174109-4182566 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 5 "Distal enterocytes: 199.2;Paneth cells: 129.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA049729, HPA071776" Supported Supported Nucleoplasm,Vesicles No No "Cluster 52: Eosinophils - Transcription" "Cluster 45: Intestine - Brush border" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm Vesicles "HPA049729: AB_2680865, HPA071776: AB_2686445" "unprognostic (4.58e-1)" "unprognostic (3.41e-3)" "unprognostic (1.36e-1)" "prognostic favorable (2.85e-4)" "unprognostic (2.28e-1)" "unprognostic (4.14e-2)" "unprognostic (2.93e-3)" "unprognostic (8.32e-2)" "unprognostic (1.86e-1)" "unprognostic (6.13e-2)" "unprognostic (7.27e-3)" "unprognostic (4.42e-2)" "unprognostic (5.84e-2)" "prognostic favorable (9.13e-4)" "unprognostic (5.17e-2)" "unprognostic (1.63e-1)" "prognostic favorable (2.58e-4)" 8.2 12.0 10.4 7.8 10.6 10.4 8.6 10.3 15.1 10.5 8.7 23.6 10.0 10.6 2.4 12.3 9.2 3.5 10.0 10.7 10.2 13.7 11.0 8.9 7.1 11.2 10.3 7.5 14.1 5.2 13.3 4.3 10.5 12.7 7.5 1.9 9.3 5.0 8.0 11.8 14.2 2.6 9.8 15.3 9.8 6.0 12.1 4.9 10.1 2.7 3.9 9.9 9.7 10.6 25.7 16.8 8.3 10.4 6.5 6.2 12.9 12.0 8.9 10.1 8.8 11.2 9.5 16.0 12.9 8.1 9.1 15.9 4.6 12.9 1.6 30.8 10.0 6.8 9.7 10.3 14.3 17.4 25.2 7.9 10.4 10.3 6.4 7.7 8.7 15.0 15.2 35.3 5.4 19.2 23.9 18.3 14.5 9.3 15.2 18.9 7.7 18.8 9.7 11.4 11.0 18.1 11.0 10.2 24.1 3.2 10.2 23.0 12.2 10.4 10.5 36.9 17.4 45.6 25.7 18.4 20.8 28.1 12.7 5.3 13.1 12.2 10.8 16.3 6.4 9.6 7.5 8.7 14.3 10.1 6.4 6.1 11.8 5.6 13.5 11.9 12.6 8.5 10.4 10.6 10.3 15.1 10.7 10.2 11.2 10.3 10.5 9.8 12.1 10.6 9.2 12.8 7.3 5.9 13.8 10.3 10.3 32.3 9.6 12.6 6.6 6.3 3.2 7.2 18.4 5.5 18.8 24.1 7.1 199.2 13.7 32.2 1.9 6.2 7.9 11.8 26.4 9.5 8.9 26.7 24.2 9.3 19.9 9.2 5.7 5.6 13.6 6.8 24.0 13.5 10.4 29.1 18.3 11.7 10.1 2.6 11.5 15.0 5.4 1.9 27.0 15.2 14.4 3.5 6.3 32.5 129.7 8.2 10.3 9.7 28.2 14.3 11.0 13.8 0.0 7.2 11.3 7.4 9.6 13.3 12.6 25.6 10.6 7.9 30.9 11.9 SIRT7 ENSG00000187531 "Sirtuin 7" Q9NRC8 17 81911939-81921323 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Transcription, Transcription regulation" "Chromatin regulator, Repressor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Gastric mucus-secreting cells: 152.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "eosinophil: 22.2" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027284, HPA028246, CAB037261, HPA053669" Approved Supported "Nucleoplasm,Nuclear speckles" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 37: Intestine - Unknown function" "Cluster 43: THP-1 - Innate immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "Nuclear speckles" "CAB037261: AB_1079989, HPA027284: , HPA028246: , HPA053669: AB_2682224" "unprognostic (8.15e-3)" "unprognostic (3.24e-2)" "unprognostic (3.26e-2)" "unprognostic (2.41e-2)" "unprognostic (1.46e-1)" "unprognostic (3.36e-2)" "prognostic unfavorable (1.97e-5)" "unprognostic (3.03e-1)" "unprognostic (2.10e-1)" "unprognostic (2.46e-2)" "unprognostic (2.79e-1)" "unprognostic (1.71e-2)" "prognostic unfavorable (1.69e-7)" "unprognostic (4.34e-3)" "unprognostic (1.20e-1)" "unprognostic (4.77e-2)" "unprognostic (2.16e-2)" 8.8 8.0 6.8 7.4 7.3 23.2 8.6 7.5 8.6 12.5 7.4 17.3 12.9 7.0 1.9 42.1 8.0 5.4 6.4 6.9 6.7 11.5 14.2 9.6 11.8 7.6 7.0 6.0 12.8 5.4 6.9 4.2 7.4 9.8 5.8 0.6 14.1 3.7 6.2 22.4 17.1 3.6 7.0 18.7 17.9 13.3 7.6 9.4 7.9 3.7 7.2 10.8 18.0 7.6 26.5 21.7 2.8 9.5 6.9 6.4 17.0 13.1 10.8 15.1 14.1 18.7 20.7 11.8 9.9 7.3 9.6 18.8 10.5 8.1 4.9 10.2 22.9 10.4 10.7 29.7 20.4 13.6 20.5 6.5 25.0 14.5 11.9 6.4 11.3 6.5 11.3 5.8 7.2 20.9 14.6 19.5 6.8 40.6 22.3 9.7 5.5 11.1 14.7 17.4 11.1 14.6 15.0 35.9 17.7 5.0 15.1 32.1 9.0 6.8 14.9 12.9 24.2 9.5 3.2 9.0 16.6 18.4 11.3 4.5 2.6 22.2 2.8 3.8 0.9 4.5 2.1 2.3 1.4 7.0 2.0 0.7 4.4 1.8 3.3 2.1 1.2 1.5 6.8 7.3 7.5 8.6 6.9 6.7 7.6 7.0 7.4 7.0 7.6 7.6 15.2 12.8 12.2 12.4 41.4 38.0 25.8 21.1 28.5 23.4 27.4 19.0 4.4 18.6 18.7 18.4 56.3 31.1 62.8 99.0 9.8 22.4 21.8 28.8 14.0 15.4 20.4 16.0 14.3 13.6 33.2 12.4 152.9 37.0 11.4 20.1 15.0 16.0 26.1 30.3 10.6 34.6 28.5 26.4 33.5 14.1 14.3 29.4 24.9 5.6 47.3 14.7 71.1 6.6 13.8 52.7 74.5 10.1 33.2 29.1 74.7 16.0 29.6 39.1 0.0 12.5 15.5 41.3 37.4 52.4 55.5 49.3 50.8 17.9 44.6 53.9 SLK "KIAA0204, se20-9, STK2" ENSG00000065613 "STE20 like kinase" Q9H2G2 10 103967140-104029233 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Urothelial cells: 201.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA015757 Approved Approved "Plasma membrane,Cytosol" NA NA 140000 "Cluster 49: Eosinophils - Unknown function" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 22: Epithelial cell types - Mixed function" "Plasma membrane, Cytosol" "HPA015757: AB_1857236" "unprognostic (1.89e-1)" "unprognostic (1.80e-1)" "unprognostic (1.38e-1)" "unprognostic (8.28e-2)" "unprognostic (1.01e-1)" "unprognostic (3.64e-1)" "unprognostic (8.67e-2)" "unprognostic (6.85e-2)" "unprognostic (1.01e-1)" "unprognostic (2.31e-1)" "prognostic unfavorable (2.77e-5)" "unprognostic (1.95e-1)" "prognostic favorable (3.95e-5)" "unprognostic (8.48e-2)" "unprognostic (3.95e-1)" "unprognostic (3.09e-2)" "unprognostic (1.07e-1)" 20.5 15.1 10.9 15.2 19.9 28.9 21.7 20.9 13.7 19.9 15.3 20.4 13.3 21.3 16.2 56.4 14.1 21.3 22.4 11.7 10.0 20.6 17.8 24.0 11.8 11.5 11.1 24.0 16.7 26.3 9.6 25.8 11.7 17.6 20.8 15.1 21.9 17.7 23.1 26.3 14.7 20.6 10.3 14.9 24.1 15.2 12.3 15.2 22.4 25.1 17.5 30.5 28.6 18.5 50.5 28.9 33.7 24.3 36.6 50.1 14.2 30.6 40.7 22.5 20.9 18.4 53.7 26.6 18.6 31.8 19.1 53.7 18.0 39.5 33.5 21.3 24.7 27.0 23.5 15.6 26.6 32.7 22.4 25.5 49.5 30.9 87.6 31.7 40.9 16.9 34.6 17.9 29.8 18.6 23.0 18.0 8.4 32.4 18.2 22.2 41.4 13.8 29.0 60.3 8.0 13.8 26.6 25.7 25.8 17.2 13.8 23.4 63.4 16.6 16.9 30.6 36.3 21.6 28.0 16.7 24.2 43.1 10.7 0.6 0.5 1.7 1.4 0.5 1.5 0.4 0.8 1.0 0.5 0.6 0.6 1.0 2.7 0.5 0.4 0.9 0.8 0.3 10.9 19.9 20.9 13.7 11.7 10.0 11.5 11.1 11.7 10.3 12.3 18.5 73.5 179.5 129.5 38.5 19.9 57.0 87.1 30.9 26.7 32.2 32.0 35.1 110.4 30.0 100.9 44.1 25.0 37.4 40.1 70.0 3.9 34.0 8.4 43.3 77.1 80.2 18.5 25.5 35.3 54.0 13.6 52.6 44.9 90.3 35.3 54.6 50.7 25.3 19.9 25.2 39.3 37.2 18.3 24.5 36.9 16.6 46.6 37.5 8.8 34.7 43.9 25.7 27.8 34.2 63.9 85.5 81.6 63.2 22.3 67.8 21.9 11.5 57.9 25.4 6.6 68.1 49.3 46.3 35.3 61.4 68.5 52.4 44.2 71.7 37.4 201.0 SMG1 "ATX, KIAA0421, LIP" ENSG00000157106 "SMG1 nonsense mediated mRNA decay associated PI3K related kinase" Q96Q15 16 18804860-18926408 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Nonsense-mediated mRNA decay" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 31.7" "Lineage enriched" "Detected in all" 4 "granulocytes: 31.7" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA006870, HPA031623, HPA073972" Approved Supported Nucleoplasm NA NA "Cluster 42: Non-specific - Transcription" "Cluster 50: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 44: Endometrium - Transcription" Nucleoplasm "HPA006870: AB_1079725, HPA031623: AB_2673962, HPA073972: AB_2686648" "unprognostic (6.34e-2)" "unprognostic (5.88e-2)" "unprognostic (5.98e-2)" "unprognostic (2.66e-1)" "unprognostic (2.44e-2)" "unprognostic (1.35e-2)" "unprognostic (1.03e-1)" "unprognostic (2.28e-1)" "unprognostic (1.22e-1)" "unprognostic (2.42e-1)" "unprognostic (8.32e-3)" "unprognostic (7.28e-2)" "unprognostic (1.05e-1)" "unprognostic (2.61e-2)" "unprognostic (1.15e-1)" "unprognostic (3.17e-2)" "unprognostic (2.45e-2)" 12.9 8.4 11.0 16.1 11.0 39.0 19.5 42.6 12.6 13.4 11.9 14.4 11.6 14.1 15.8 14.2 12.1 10.8 13.5 12.0 7.5 14.6 17.8 11.4 21.6 7.5 6.7 18.6 13.0 15.2 10.2 11.5 9.9 12.1 15.9 20.9 12.0 10.9 53.1 42.0 13.6 13.2 1.9 15.9 12.8 14.5 12.6 29.9 18.1 35.4 19.1 15.4 13.2 16.6 42.2 27.5 25.5 18.1 28.6 29.9 18.8 19.1 18.8 20.4 22.7 24.4 15.1 57.5 26.8 26.8 21.5 23.3 29.6 16.7 32.3 37.2 18.4 26.2 25.8 31.4 23.1 35.7 19.9 17.7 27.5 42.4 50.5 20.1 29.1 30.7 41.0 31.0 22.8 22.0 24.8 20.9 27.2 15.3 15.7 28.4 34.2 19.8 17.6 32.1 23.0 17.6 29.9 19.9 20.8 20.8 15.9 22.3 37.0 30.2 20.4 19.0 28.7 15.8 21.8 37.0 20.2 27.1 18.6 31.7 2.7 4.2 6.6 3.2 3.2 4.0 4.4 4.8 2.9 7.6 5.7 5.1 8.4 2.6 7.2 5.3 4.5 1.4 11.0 11.0 42.6 12.6 12.0 7.5 7.5 6.7 9.9 1.9 12.6 16.6 83.2 76.9 85.4 58.4 98.8 193.2 73.0 26.9 112.1 52.0 71.3 40.5 48.1 32.9 67.1 27.6 75.0 21.3 97.4 65.5 3.9 21.7 20.3 88.1 81.1 66.5 39.4 44.8 81.5 23.6 19.0 57.3 90.7 140.0 39.3 66.1 37.9 46.1 24.1 42.1 75.2 41.8 36.7 48.0 112.8 24.9 29.8 82.5 39.2 68.4 61.4 20.5 72.1 48.7 87.5 34.6 76.9 26.4 82.2 94.2 43.0 15.6 45.9 44.8 46.0 118.2 63.1 49.6 32.2 107.1 204.4 30.0 97.6 37.6 46.4 95.4 SMS "MRSR, SPMSY, SpS, SRS" ENSG00000102172 "Spermine synthase" P52788 X 21940709-21994837 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Polyamine biosynthesis" Transferase "Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Cytotrophoblasts: 644.3;Distal tubular cells: 608.4;Syncytiotrophoblasts: 869.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029849, HPA029852" Approved Approved "Nuclear bodies,Cytosol" No No 16000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 7: Kidney - Transmembrane transport" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 47: Cytotrophoblasts - Unknown function" "Nuclear bodies" Cytosol "HPA029849: AB_10602072, HPA029852: AB_10611521" "unprognostic (2.51e-2)" "unprognostic (2.91e-1)" "unprognostic (1.89e-2)" "unprognostic (1.39e-1)" "unprognostic (1.43e-1)" "prognostic unfavorable (7.49e-4)" "prognostic unfavorable (7.79e-8)" "unprognostic (1.02e-2)" "unprognostic (2.72e-1)" "unprognostic (3.18e-3)" "unprognostic (3.95e-3)" "unprognostic (2.45e-1)" "prognostic unfavorable (7.85e-5)" "unprognostic (2.70e-1)" "unprognostic (1.22e-1)" "unprognostic (1.67e-1)" "unprognostic (8.50e-2)" 29.7 94.3 52.0 34.7 53.5 50.8 49.6 56.0 61.9 42.7 43.7 52.0 54.9 44.7 63.6 30.6 28.6 40.5 53.0 53.9 50.2 119.9 44.3 36.2 47.8 48.6 46.7 91.2 24.1 28.0 31.5 114.2 49.1 136.0 50.4 49.5 39.7 42.2 34.6 21.4 50.9 39.6 47.0 41.3 39.3 30.2 53.9 50.7 55.3 32.5 47.3 55.1 32.0 49.6 664.3 161.2 265.3 107.1 71.9 121.4 86.3 174.6 102.6 261.7 249.1 204.0 213.0 239.5 59.8 180.0 722.9 142.2 265.5 318.2 508.2 111.0 128.6 124.4 201.0 145.5 129.4 242.2 103.8 76.8 93.7 266.4 497.2 189.2 254.5 93.6 270.6 32.7 366.7 139.2 181.3 244.1 474.9 149.0 244.3 176.0 188.5 182.9 354.3 90.1 131.4 105.7 143.1 181.8 489.1 687.6 163.9 101.3 232.3 194.4 193.6 405.0 294.5 23.8 52.6 142.2 378.4 107.5 275.6 9.1 57.5 102.5 18.9 59.9 23.7 34.6 29.6 33.3 51.1 22.0 19.1 22.8 55.7 31.4 73.9 10.7 55.4 37.3 52.0 53.5 56.0 61.9 53.9 50.2 48.6 46.7 49.1 47.0 53.9 49.6 43.4 25.6 21.9 33.6 61.5 65.9 203.0 206.1 42.1 35.7 116.2 66.3 36.1 81.5 115.0 110.3 12.5 644.3 46.7 61.2 608.4 246.3 1.9 126.4 70.4 61.9 58.8 95.2 45.6 152.3 313.1 86.6 57.6 215.9 40.5 249.5 59.6 49.8 364.7 21.9 40.2 103.6 146.5 157.3 200.3 7.1 95.4 153.1 92.5 21.5 250.7 46.8 48.4 22.1 8.1 165.6 63.9 103.4 45.6 276.2 137.0 466.7 78.9 43.2 65.7 76.6 114.2 6.0 181.3 54.1 50.6 869.6 63.7 271.2 119.1 153.1 SMURF1 KIAA1625 ENSG00000198742 "SMAD specific E3 ubiquitin protein ligase 1" Q9HCE7 7 99027440-99144108 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Differentiation, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 100.2;Microglial cells: 89.9;Oligodendrocytes: 211.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "A-431: 9.2;BJ: 15.2;EFO-21: 12.8;HDLM-2: 8.1;PC-3: 18.2;U-2 OS: 8.3;U-251 MG: 9.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019671, HPA055245" Approved Approved Nucleoplasm,Vesicles NA NA "Cluster 72: Non-specific - Transcription" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Vesicles Nucleoplasm "HPA019671: , HPA055245: AB_2682757" "unprognostic (2.21e-1)" "unprognostic (6.15e-2)" "unprognostic (8.88e-2)" "unprognostic (1.04e-1)" "unprognostic (1.96e-2)" "unprognostic (1.42e-1)" "unprognostic (1.29e-1)" "unprognostic (1.73e-1)" "unprognostic (2.00e-1)" "unprognostic (2.15e-2)" "unprognostic (3.92e-3)" "unprognostic (2.58e-1)" "unprognostic (1.46e-1)" "unprognostic (7.83e-2)" "unprognostic (1.68e-1)" "unprognostic (3.81e-1)" "unprognostic (4.62e-2)" 17.7 13.9 0.7 0.3 0.8 1.1 14.3 0.5 0.9 13.4 1.1 12.7 0.0 12.3 0.0 22.0 12.2 0.0 9.0 0.8 0.3 11.6 11.7 18.5 0.0 1.1 0.7 20.6 15.5 0.0 11.2 0.0 1.0 13.3 0.0 0.7 15.0 0.0 12.7 20.2 11.7 0.0 0.1 10.0 16.1 20.9 0.8 0.0 8.5 0.0 0.0 12.4 15.5 1.8 9.2 0.0 0.1 0.2 0.0 0.0 1.3 15.2 0.1 0.4 0.0 0.0 0.4 1.6 12.8 0.0 0.3 4.5 0.0 0.1 0.0 8.1 2.3 0.0 0.7 0.7 0.1 0.1 3.6 0.0 0.0 0.3 0.0 0.0 0.0 0.0 5.9 0.1 0.8 0.1 1.3 1.9 2.8 0.0 18.2 2.5 1.2 0.0 0.0 0.4 0.3 1.5 0.7 0.5 0.9 0.3 0.3 0.0 1.4 0.0 8.3 1.3 9.4 2.0 4.9 1.3 0.6 1.2 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.8 0.5 0.9 0.8 0.3 1.1 0.7 1.0 0.1 0.8 1.8 9.7 19.2 27.5 59.4 8.9 25.9 25.5 10.0 25.0 28.2 10.3 7.2 4.4 20.0 18.5 12.9 8.4 7.7 4.6 17.1 1.9 14.7 6.2 13.3 8.8 12.8 11.4 0.4 100.2 16.0 10.3 10.8 46.9 23.3 2.5 6.8 9.7 9.3 6.6 26.9 77.0 11.0 4.1 4.1 10.9 8.5 6.2 8.8 8.8 89.9 5.5 3.3 5.2 70.4 211.9 34.8 14.9 13.9 5.4 37.9 7.1 5.5 22.1 7.6 6.6 10.4 15.1 32.8 2.4 19.3 22.0 21.1 8.8 6.5 8.1 77.5 SMURF2 ENSG00000108854 "SMAD specific E3 ubiquitin protein ligase 2" Q9HAU4 17 64542282-64662307 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Host-virus interaction, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "BJ: 221.1;HBF TERT88: 157.4;LHCN-M2: 164.1;TIME: 207.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA071508 Enhanced Supported "Nuclear speckles" NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 28: Placenta - Pregnancy" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "Nuclear speckles" "HPA071508: AB_2686406" "unprognostic (1.21e-1)" "unprognostic (2.07e-2)" "unprognostic (1.59e-2)" "unprognostic (3.24e-1)" "unprognostic (6.19e-2)" "unprognostic (7.33e-2)" "unprognostic (2.67e-2)" "unprognostic (1.50e-1)" "unprognostic (7.94e-2)" "unprognostic (1.09e-2)" "unprognostic (5.46e-3)" "unprognostic (2.54e-1)" "unprognostic (5.55e-2)" "unprognostic (1.98e-2)" "unprognostic (7.82e-2)" "unprognostic (2.20e-2)" "unprognostic (1.41e-1)" 6.8 4.3 3.3 6.2 3.9 5.9 5.2 5.3 3.4 7.3 3.4 5.3 6.9 5.9 2.3 4.4 5.8 7.1 4.1 3.1 3.3 7.0 3.8 10.5 5.0 4.6 2.7 4.8 6.5 6.3 3.4 13.3 2.8 7.4 4.8 12.5 6.2 5.2 3.0 5.0 10.1 6.1 3.2 5.4 7.8 13.0 3.6 7.8 8.3 6.2 6.5 7.5 3.2 3.8 67.0 17.8 15.3 9.1 11.0 41.5 7.6 221.1 103.2 88.2 73.4 10.4 45.5 8.6 14.5 38.8 29.9 15.2 16.0 37.2 157.4 4.3 12.9 9.1 10.9 11.8 12.0 12.2 5.5 11.8 16.1 109.5 48.5 52.7 97.0 11.9 13.0 7.5 164.1 13.2 28.3 4.8 9.9 8.8 23.8 6.1 38.4 5.2 20.1 11.1 16.0 17.9 14.4 5.8 10.0 24.6 11.7 8.4 207.6 93.8 44.4 39.2 139.6 10.4 11.7 13.9 23.7 7.3 28.4 1.0 0.6 1.4 1.0 0.4 1.1 0.7 0.8 1.1 0.7 0.9 0.9 0.9 1.4 2.7 0.3 0.6 0.2 0.5 3.3 3.9 5.3 3.4 3.1 3.3 4.6 2.7 2.8 3.2 3.6 3.8 40.2 32.1 26.0 96.3 18.6 43.8 30.8 10.0 25.0 26.4 23.3 18.7 10.3 7.2 16.1 9.2 43.8 13.2 35.4 13.8 9.8 18.1 29.0 29.0 37.2 39.3 17.9 2.5 46.1 10.0 3.6 28.1 12.2 39.7 13.3 21.4 38.2 5.1 13.6 26.9 40.9 11.2 10.2 17.3 25.5 9.2 12.5 22.8 21.4 101.2 13.2 21.4 20.6 101.0 52.8 26.5 24.7 12.0 18.0 25.2 28.0 9.6 14.4 46.7 0.0 37.4 23.3 37.1 21.3 13.7 39.8 7.3 33.5 16.2 13.8 24.6 SMYD1 "BOP, KMT3D, ZMYND22" ENSG00000115593 "SET and MYND domain containing 1" Q8NB12 2 88067825-88113384 "Enzymes, Predicted intracellular proteins" "Transcription, Transcription regulation" "DNA-binding, Methyltransferase, Repressor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 11 "heart muscle: 160.4;skeletal muscle: 493.6;tongue: 301.3" "Cell type enriched" "Detected in some" 27 "Cardiomyocytes: 208.0" "Cancer enhanced" "Detected in some" "head and neck cancer: 0.9;stomach cancer: 1.6" "Region enriched" "Detected in some" 4 "basal ganglia: 4.1" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 5 "HSkMC: 1.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in single" HPA062282 Enhanced NA NA "Cluster 13: Striated muscle - Muscle contraction" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 54: Cardiomyocytes - Muscle contraction" "HPA062282: AB_2684736" "unprognostic (1.93e-2)" "unprognostic (2.49e-1)" "unprognostic (4.09e-2)" "unprognostic (8.51e-3)" "unprognostic (2.74e-1)" "unprognostic (3.91e-1)" "unprognostic (8.81e-3)" "unprognostic (1.40e-1)" 0.0 0.0 0.2 0.2 4.1 0.0 5.4 0.1 1.0 0.0 0.0 17.9 2.0 0.0 0.0 7.3 0.0 0.0 160.4 0.4 0.1 0.0 0.0 0.1 0.0 0.1 0.2 0.0 0.3 2.4 0.0 0.0 0.3 4.0 1.9 0.0 3.9 0.0 493.6 0.1 7.0 28.1 0.1 0.0 7.3 0.3 0.1 0.4 0.1 301.3 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 4.1 0.1 1.0 0.4 0.1 0.1 0.2 0.3 0.1 0.1 0.9 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 7.7 208.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 1.5 0.0 0.0 0.3 0.0 0.0 4.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.5 1.5 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 SMYD2 "HSKM-B, KMT3C, ZMYND14" ENSG00000143499 "SET and MYND domain containing 2" Q9NRG4 1 214281102-214337131 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Transcription, Transcription regulation" "Chromatin regulator, Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 5 "heart muscle: 198.8;skeletal muscle: 92.4" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 148.0;Cytotrophoblasts: 168.7;Early spermatids: 134.5;Extravillous trophoblasts: 110.5;Late spermatids: 120.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA029023 Uncertain Approved Mitochondria,Cytosol NA NA "Cluster 15: NK-cells - Transcription" "Cluster 38: Heart - Muscle contraction" "Cluster 28: BEWO - Transcription regulation" "Cluster 47: Cytotrophoblasts - Unknown function" Cytosol Mitochondria "HPA029023: AB_10601605" "unprognostic (8.53e-2)" "prognostic unfavorable (1.53e-5)" "unprognostic (5.98e-2)" "unprognostic (1.00e-2)" "unprognostic (8.55e-2)" "unprognostic (2.53e-2)" "unprognostic (2.24e-2)" "unprognostic (1.72e-2)" "unprognostic (1.90e-3)" "unprognostic (1.65e-1)" "unprognostic (9.44e-2)" "unprognostic (2.77e-1)" "prognostic favorable (8.68e-4)" "unprognostic (2.65e-1)" "unprognostic (4.92e-2)" "unprognostic (8.10e-2)" "unprognostic (6.37e-2)" 15.5 15.0 12.4 9.0 13.0 8.9 18.7 13.5 32.1 12.2 17.8 12.9 13.8 9.5 7.5 18.1 27.6 9.3 198.8 14.6 16.1 20.4 26.2 18.1 13.5 14.7 16.7 12.0 19.1 6.9 17.1 27.3 14.2 12.1 14.3 14.3 13.7 8.1 92.4 11.4 12.6 10.1 14.5 15.1 19.2 24.3 14.4 22.6 20.3 4.2 14.2 11.8 10.1 14.4 64.4 14.5 22.7 16.8 21.7 37.7 102.4 36.6 28.8 41.8 46.6 68.3 52.0 34.6 36.7 39.8 19.7 28.9 21.3 63.5 36.8 28.3 29.8 10.1 30.0 46.7 19.9 47.6 7.4 42.9 31.2 30.5 21.6 27.2 32.1 29.5 35.0 7.5 36.4 33.5 32.6 26.1 21.3 32.4 26.3 20.6 59.9 27.8 33.9 45.2 23.7 55.3 28.9 95.0 73.3 47.8 75.5 30.1 38.6 32.9 49.6 18.0 55.2 33.2 13.0 39.2 43.1 35.1 37.8 15.8 10.0 14.4 15.0 5.7 17.8 15.4 22.5 19.9 9.5 7.5 19.3 18.0 0.9 29.2 1.9 6.4 26.7 13.0 12.4 13.0 13.5 32.1 14.6 16.1 14.7 16.7 14.2 14.5 14.4 14.4 10.5 19.2 9.7 7.5 13.7 20.6 16.5 40.0 25.0 8.7 16.8 19.9 148.0 24.3 17.7 3.7 0.0 168.7 12.2 10.0 31.3 34.3 134.5 48.7 9.9 15.6 4.2 8.6 60.7 20.0 110.5 11.1 11.7 17.4 3.8 27.9 17.2 20.3 38.4 15.2 26.9 13.4 14.2 21.5 10.6 120.4 11.8 11.4 16.0 22.5 11.7 28.1 9.2 7.1 10.3 26.1 11.7 3.8 16.4 16.1 21.9 34.6 69.6 8.0 13.1 6.8 16.7 13.9 39.6 28.9 18.0 85.9 16.8 30.0 19.3 10.9 SMYD3 "KMT3E, ZMYND1, ZNFN3A1" ENSG00000185420 "SET and MYND domain containing 3" Q9H7B4 1 245749342-246507312 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Chromatin regulator, Methyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Astrocytes: 406.1;Excitatory neurons: 725.6;Inhibitory neurons: 788.3;Microglial cells: 277.3;Oligodendrocyte precursor cells: 372.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HMC-1: 402.2;K-562: 162.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB012229, HPA045821, HPA054352" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm Cytosol "CAB012229: , HPA045821: AB_2679461, HPA054352: AB_2682458" "unprognostic (7.00e-3)" "unprognostic (7.45e-2)" "unprognostic (1.52e-1)" "unprognostic (6.18e-3)" "unprognostic (3.32e-2)" "unprognostic (5.08e-3)" "unprognostic (3.25e-3)" "unprognostic (1.72e-3)" "unprognostic (4.53e-2)" "unprognostic (1.57e-1)" "unprognostic (1.71e-1)" "unprognostic (2.10e-1)" "unprognostic (3.78e-5)" "unprognostic (9.03e-3)" "unprognostic (2.14e-1)" "unprognostic (1.08e-2)" "unprognostic (1.58e-1)" 7.9 12.1 9.5 5.0 9.6 9.7 11.1 16.4 9.6 9.1 5.8 7.5 5.0 7.1 22.1 6.4 10.3 8.2 6.7 10.4 10.2 9.4 6.0 9.8 7.7 7.0 10.3 8.2 7.8 9.5 9.2 5.3 9.8 6.8 8.8 7.0 6.6 5.4 11.6 8.0 6.0 6.7 4.4 5.7 7.3 8.7 11.6 10.8 16.0 9.8 7.7 10.1 5.9 6.8 20.8 12.6 17.8 15.4 19.9 27.1 17.3 28.7 21.4 33.4 74.4 16.2 23.7 33.5 22.6 27.0 20.8 13.2 16.3 32.1 111.3 17.7 16.4 20.0 17.9 19.5 37.3 20.1 402.2 73.5 7.6 44.3 28.5 25.3 23.1 23.5 162.0 11.5 33.0 7.0 38.8 38.8 15.9 29.1 19.5 35.5 21.3 48.9 24.5 29.3 41.9 19.8 13.5 2.0 26.4 19.3 16.5 33.8 17.6 15.9 11.0 11.4 34.8 57.0 16.7 17.3 30.5 27.3 18.8 13.1 4.6 11.5 12.9 4.1 13.7 14.2 13.7 16.4 8.0 15.8 15.1 16.1 3.2 27.5 4.6 5.0 16.2 12.1 9.5 9.6 16.4 9.6 10.4 10.2 7.0 10.3 9.8 4.4 11.6 6.8 14.2 6.4 30.7 406.1 16.2 12.2 14.7 26.5 13.1 7.7 8.7 9.3 9.1 4.3 18.9 12.9 22.9 8.1 15.8 5.1 15.6 22.3 54.8 24.9 14.3 12.7 25.1 6.3 725.6 31.1 42.6 15.9 9.2 13.6 110.9 25.7 12.5 4.9 12.3 10.1 788.3 7.9 26.4 4.1 10.2 110.9 11.1 6.0 12.4 277.3 3.7 7.6 16.5 372.4 136.5 24.0 3.7 17.3 19.9 4.8 4.0 19.3 36.9 13.2 0.0 12.1 20.7 19.6 27.5 12.0 11.5 7.3 18.3 46.3 8.8 10.0 SNRK "FLJ20224, HSNFRK, KIAA0096" ENSG00000163788 "SNF related kinase" Q9NRH2 3 43286512-43424764 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Sertoli cells: 124.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HUVEC TERT2: 126.0;TIME: 74.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA042163 Uncertain Approved "Nucleoplasm,Vesicles,Plasma membrane,Cell Junctions" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 48: Smooth muscle cells - ECM organization" "Vesicles, Plasma membrane, Cell Junctions" Nucleoplasm "HPA042163: AB_10794645" "prognostic favorable (9.28e-4)" "unprognostic (8.46e-2)" "unprognostic (2.79e-3)" "unprognostic (6.41e-2)" "unprognostic (1.14e-1)" "unprognostic (1.16e-3)" "unprognostic (2.00e-2)" "unprognostic (1.08e-1)" "unprognostic (2.63e-3)" "unprognostic (4.25e-1)" "unprognostic (2.32e-1)" "unprognostic (4.68e-2)" "prognostic favorable (9.41e-5)" "unprognostic (9.21e-3)" "unprognostic (2.04e-1)" "unprognostic (7.06e-3)" "unprognostic (7.38e-2)" 37.6 10.3 9.7 17.2 9.7 58.4 26.5 27.7 13.2 21.7 9.8 14.6 16.1 23.1 7.8 19.7 13.6 20.4 16.3 9.5 12.5 20.0 25.4 26.4 19.8 14.0 11.5 14.4 22.7 18.5 11.4 33.3 14.7 11.2 11.9 18.8 11.4 10.8 14.3 30.3 17.2 22.9 9.5 33.0 14.4 11.1 13.2 40.5 27.3 21.6 14.7 19.8 21.7 8.7 8.4 5.0 9.1 8.8 26.6 9.5 8.7 8.8 14.8 9.4 9.1 6.9 11.8 13.2 6.8 11.2 6.2 5.3 10.7 18.9 9.6 15.1 8.8 15.0 9.1 8.1 13.8 17.1 16.1 10.5 12.7 10.6 17.9 9.5 126.0 14.9 6.7 14.9 8.7 4.4 17.3 15.0 10.1 4.6 22.6 11.7 6.7 14.0 24.2 14.1 6.4 13.4 7.7 8.1 11.1 7.9 5.5 21.4 74.1 8.2 8.3 9.5 10.4 23.7 18.3 11.0 5.8 20.1 12.0 9.4 4.2 7.6 9.5 7.5 13.0 3.6 8.3 9.6 4.0 3.6 12.1 13.1 27.7 11.0 7.1 1.2 9.7 9.7 9.7 9.7 27.7 13.2 9.5 12.5 14.0 11.5 14.7 9.5 13.2 8.7 88.4 32.1 24.1 30.0 29.0 52.8 10.3 6.4 12.5 52.1 9.7 8.6 17.7 15.7 15.0 16.5 16.7 7.7 57.6 37.0 11.7 10.9 50.4 23.3 16.2 84.2 10.8 10.3 21.6 8.9 3.2 16.4 12.8 19.8 14.5 8.9 98.6 25.2 13.7 30.3 43.2 10.7 12.2 24.8 19.0 7.5 12.5 26.5 23.2 34.7 21.9 16.3 65.9 24.6 10.7 11.2 20.6 11.7 27.3 12.7 25.2 12.2 19.2 18.3 124.9 31.3 49.1 11.1 16.2 13.7 51.3 8.2 61.2 9.5 11.1 18.0 SOAT1 "ACAT, SOAT, STAT" ENSG00000057252 "Sterol O-acyltransferase 1" P35610 1 179293714-179358680 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted membrane proteins" "Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism" "Acyltransferase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 4 "adrenal gland: 165.3" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009533, HPA047171" Enhanced Enhanced "Endoplasmic reticulum" NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 17: Adrenal gland - Steroid metabolism" "Cluster 28: BEWO - Transcription regulation" "Cluster 4: Macrophages - Innate immune response" "Endoplasmic reticulum" "CAB009533: AB_633499, HPA047171: AB_2679967" "unprognostic (3.29e-2)" "unprognostic (7.60e-2)" "unprognostic (1.11e-1)" "unprognostic (3.21e-2)" "unprognostic (2.83e-1)" "unprognostic (1.81e-3)" "unprognostic (7.81e-3)" "unprognostic (3.29e-1)" "unprognostic (9.00e-2)" "unprognostic (9.84e-2)" "unprognostic (1.06e-1)" "unprognostic (5.45e-3)" "unprognostic (7.02e-3)" "unprognostic (4.67e-3)" "unprognostic (9.64e-2)" "unprognostic (4.67e-2)" "unprognostic (1.82e-1)" 14.6 165.3 4.2 18.1 5.7 17.5 8.2 5.5 6.6 13.7 9.0 13.0 12.2 11.7 6.6 4.8 17.9 20.5 5.4 3.3 6.8 12.7 14.1 20.9 15.1 10.1 6.1 10.7 27.0 13.4 6.3 19.1 8.0 27.7 14.8 10.3 39.4 9.3 4.0 5.7 12.7 16.5 8.0 15.1 16.3 11.0 6.7 8.1 9.2 3.7 13.1 11.7 4.5 12.8 74.6 34.1 27.7 41.0 104.7 56.6 147.3 35.1 61.7 76.2 88.3 35.2 82.6 42.0 53.9 64.4 92.6 26.8 88.6 20.9 81.8 48.0 18.2 19.5 26.7 36.9 42.9 33.5 7.5 45.4 13.3 89.2 75.8 32.1 33.3 50.5 42.7 21.0 120.0 15.9 35.9 10.8 13.4 11.8 11.2 44.4 35.8 24.4 66.1 45.9 8.4 21.5 54.3 22.9 20.1 32.3 24.0 22.8 31.9 89.8 43.1 99.5 78.2 29.4 115.3 35.5 35.7 17.9 170.6 55.4 53.4 1.6 26.4 34.2 25.0 12.9 24.0 24.8 48.9 10.4 23.0 23.3 39.3 37.9 23.7 8.8 33.2 32.5 4.2 5.7 5.5 6.6 3.3 6.8 10.1 6.1 8.0 8.0 6.7 12.8 14.9 22.4 33.4 11.4 16.0 9.9 10.1 11.3 8.0 7.3 7.2 4.6 8.5 30.0 14.5 20.2 14.6 17.6 21.2 16.0 1.9 42.5 29.5 34.9 32.8 16.0 59.9 9.0 12.1 25.0 51.6 21.3 18.3 34.5 14.0 9.2 15.4 24.2 70.3 6.7 15.0 25.5 22.4 77.4 41.9 14.5 32.6 74.9 23.2 29.0 55.4 7.6 19.6 10.6 7.3 20.3 13.3 25.9 17.7 26.7 8.7 14.9 46.2 14.5 26.3 9.2 13.5 6.8 9.7 5.0 5.3 8.8 24.8 44.3 15.5 8.5 SOAT2 ACAT2 ENSG00000167780 "Sterol O-acyltransferase 2" O75908 12 53103486-53124535 "Enzymes, Metabolic proteins, Predicted membrane proteins, Transporters" "Cholesterol metabolism, Lipid metabolism, Steroid metabolism, Sterol metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "intestine: 19.5" "Cell type enriched" "Detected in some" 5 "Proximal enterocytes: 14.3" "Group enriched" "Detected in some" 8 "liver cancer: 5.2;testis cancer: 5.5" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "MAIT T-cell: 1.1" "Lineage enriched" "Detected in single" 5 "T-cells: 1.1" "Group enriched" "Detected in some" 5 "CACO-2: 9.5;Hep G2: 22.6;U-266/70: 7.2" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 56: Intestine - Transmembrane transport" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 45: Enterocytes - Digestion" "unprognostic (2.53e-1)" "unprognostic (2.72e-3)" "unprognostic (1.15e-1)" "unprognostic (1.40e-1)" "unprognostic (1.30e-4)" "unprognostic (3.88e-3)" "unprognostic (9.26e-2)" "unprognostic (4.20e-2)" "unprognostic (1.32e-1)" "unprognostic (3.29e-1)" "unprognostic (1.06e-2)" "unprognostic (2.53e-1)" "unprognostic (1.83e-2)" "unprognostic (9.05e-2)" "unprognostic (2.37e-1)" "unprognostic (7.58e-3)" "unprognostic (3.28e-1)" 0.3 0.0 0.0 0.1 0.0 0.2 0.3 0.0 0.1 0.8 0.0 0.2 11.6 0.4 0.2 0.1 0.6 0.4 0.1 0.0 0.0 0.4 2.9 0.1 0.3 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.4 0.1 0.0 0.4 0.1 0.0 0.3 19.5 0.0 0.0 2.1 0.2 0.2 0.0 0.1 0.2 0.1 0.2 0.3 0.6 0.0 0.2 0.2 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.3 0.4 9.5 0.1 0.0 0.0 0.5 0.0 0.8 0.0 0.0 0.7 0.0 0.0 1.0 0.0 22.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.9 0.0 0.0 0.0 0.4 2.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 7.2 1.4 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.4 0.7 0.0 0.0 0.1 0.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.3 1.5 0.6 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.1 1.3 0.0 0.0 0.0 0.2 0.6 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.2 0.3 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.2 0.0 2.5 0.0 0.0 0.0 14.3 0.8 0.0 0.0 0.0 0.0 0.2 0.1 0.2 0.0 0.0 0.0 0.6 0.0 0.3 0.0 SPEG "APEG1, BPEG, KIAA1297, MGC12676, MYLK6, SPEGalpha, SPEGbeta" ENSG00000072195 "Striated muscle enriched protein kinase" Q15772 2 219434843-219493629 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Differentiation "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 174.8" "Cell type enhanced" "Detected in many" "Astrocytes: 45.7;Cardiomyocytes: 61.5;Late spermatids: 39.6;Sertoli cells: 46.0;Smooth muscle cells: 32.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "hTERT-RPE1: 45.9;U-87 MG: 23.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA018904 Enhanced Approved Vesicles NA NA "Cluster 13: Striated muscle - Muscle contraction" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 48: Smooth muscle cells - ECM organization" Vesicles "HPA018904: AB_1844924" "unprognostic (3.70e-1)" "unprognostic (1.23e-2)" "unprognostic (5.05e-3)" "unprognostic (2.45e-4)" "unprognostic (2.04e-2)" "unprognostic (4.65e-3)" "unprognostic (2.41e-2)" "unprognostic (1.12e-1)" "unprognostic (8.92e-3)" "unprognostic (2.29e-2)" "unprognostic (8.66e-4)" "unprognostic (1.06e-1)" "unprognostic (3.47e-9)" "unprognostic (1.14e-1)" "unprognostic (7.01e-2)" "unprognostic (5.95e-4)" "unprognostic (1.28e-3)" 16.1 6.8 16.8 7.7 18.7 0.0 15.3 15.5 20.7 75.5 9.7 174.8 5.3 89.5 6.2 15.6 70.0 7.3 48.5 19.8 14.5 4.1 1.3 8.7 0.6 16.1 15.8 21.9 3.4 4.4 34.3 4.5 14.6 58.8 3.8 1.0 10.0 25.5 118.0 7.8 31.9 23.1 15.3 2.4 48.1 5.4 15.3 0.5 5.9 21.7 0.2 87.7 42.1 15.6 6.1 0.5 3.1 4.9 1.6 4.7 1.8 13.1 8.5 8.6 6.4 4.5 1.9 0.0 4.5 9.7 4.3 7.2 2.5 3.1 3.4 0.0 1.7 0.0 6.1 0.3 2.1 0.0 0.5 13.2 4.6 7.8 1.9 45.9 0.0 3.2 3.5 0.0 6.1 1.6 0.1 18.8 6.5 0.0 2.4 2.8 7.0 1.1 8.5 0.0 3.4 15.1 0.6 0.0 0.3 14.3 0.3 0.2 0.0 20.6 21.3 2.4 21.1 0.4 0.0 0.2 23.3 0.1 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 16.8 18.7 15.5 20.7 19.8 14.5 16.1 15.8 14.6 15.3 15.3 15.6 2.4 0.0 2.2 45.7 0.4 3.2 6.0 1.3 2.8 5.3 10.3 14.6 61.5 4.3 0.1 1.8 2.1 0.6 1.4 4.1 0.0 1.5 21.8 0.9 3.6 2.2 6.7 2.7 20.5 1.2 0.9 10.0 3.6 1.3 0.0 1.0 5.7 3.1 1.1 5.0 20.9 4.1 0.0 5.6 1.9 39.6 10.5 1.6 3.6 4.7 1.4 8.4 0.0 5.0 1.0 0.2 3.2 18.8 0.9 6.5 8.5 4.3 0.1 0.9 46.0 17.1 32.4 11.6 3.7 0.2 1.4 1.4 1.2 0.4 3.5 5.3 SPHK1 SPHK ENSG00000176170 "Sphingosine kinase 1" Q9NYA1 17 76376584-76387860 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Calmodulin-binding, Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Ductal cells: 105.4;Muller glia cells: 165.1;Pancreatic endocrine cells: 101.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "plasmacytoid DC: 4.8" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "Hep G2: 127.6;TIME: 108.9;U-251 MG: 142.1" "Low region specificity" "Detected in many" "Region enhanced" "Detected in some" "olfactory bulb: 5.7" "HPA022829, HPA028761" Uncertain Supported "Plasma membrane,Cytosol" NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 1: Pancreatic cells - Digestion" "Plasma membrane, Cytosol" "HPA022829: AB_1857438, HPA028761: AB_10600814" "unprognostic (1.04e-1)" "unprognostic (6.30e-2)" "unprognostic (1.09e-2)" "unprognostic (8.66e-2)" "unprognostic (2.25e-2)" "unprognostic (1.82e-1)" "unprognostic (1.68e-2)" "unprognostic (9.32e-3)" "unprognostic (3.13e-1)" "unprognostic (7.43e-2)" "unprognostic (8.99e-3)" "unprognostic (2.18e-1)" "prognostic unfavorable (5.14e-6)" "unprognostic (1.39e-1)" "unprognostic (4.82e-2)" "unprognostic (8.29e-2)" "unprognostic (1.10e-3)" 18.9 4.1 4.0 10.5 3.0 17.3 18.0 2.1 3.9 11.0 2.3 7.0 1.9 6.7 3.9 23.8 9.4 11.9 17.5 2.9 3.9 21.4 3.8 24.3 8.1 4.0 4.1 4.3 14.4 4.8 4.9 2.5 4.5 7.3 1.1 8.4 19.9 1.5 3.2 15.6 7.0 3.2 2.3 5.0 6.7 5.8 8.5 3.5 10.6 0.8 4.1 11.3 13.1 3.9 36.9 3.7 15.2 0.8 7.6 7.0 15.8 82.6 54.0 67.8 40.8 19.4 3.9 1.8 7.4 61.0 28.9 7.7 11.7 105.4 16.4 1.6 6.2 0.5 28.3 127.6 16.6 1.3 2.9 13.6 2.1 105.9 41.3 28.8 66.0 3.7 17.3 0.2 13.5 46.6 3.5 0.6 0.9 8.2 29.7 2.5 4.1 2.8 3.7 0.5 2.0 3.6 8.3 0.9 74.4 9.1 3.0 5.1 108.9 105.8 20.8 82.3 142.1 1.7 0.4 1.6 80.5 6.5 16.1 1.5 1.9 0.0 0.7 0.9 0.2 0.0 0.1 0.2 0.5 0.1 0.0 0.1 0.2 0.0 0.2 4.8 0.0 0.8 4.0 3.0 2.1 3.9 2.9 3.9 4.0 4.1 4.5 2.3 8.5 3.9 22.0 0.0 0.0 1.0 2.8 12.6 57.0 18.6 2.8 1.5 31.1 29.1 5.3 47.1 6.6 1.8 0.0 1.2 9.1 1.0 0.0 105.4 0.2 15.3 13.5 51.2 0.0 22.3 0.5 12.7 16.9 27.5 3.1 60.7 7.0 0.4 4.2 0.2 30.1 33.7 1.6 2.4 6.1 8.9 45.4 1.4 3.7 39.9 12.4 1.0 61.5 165.1 3.1 0.0 0.1 101.8 1.2 19.9 3.5 68.9 0.8 2.5 2.0 3.9 0.0 17.3 54.3 0.0 9.5 6.7 10.7 1.4 4.2 0.8 0.4 27.0 SPHK2 ENSG00000063176 "Sphingosine kinase 2" Q9NRA0 19 48619291-48630717 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Bipolar cells: 68.5;Cone photoreceptor cells: 77.2;Rod photoreceptor cells: 79.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "NB-4: 64.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049062 Supported Nucleoplasm NA NA "Cluster 24: B-cells - Unknown function" "Cluster 45: Intestine - Brush border" "Cluster 24: NB-4 - Immune response" "Cluster 9: Photoreceptor cells - Phototransduction" Nucleoplasm "HPA049062: " "unprognostic (5.33e-2)" "unprognostic (4.11e-2)" "unprognostic (9.61e-2)" "prognostic unfavorable (5.19e-4)" "unprognostic (2.10e-1)" "unprognostic (7.19e-3)" "unprognostic (3.04e-1)" "unprognostic (4.45e-3)" "unprognostic (7.28e-2)" "unprognostic (2.80e-1)" "prognostic favorable (9.30e-4)" "unprognostic (1.25e-1)" "prognostic favorable (2.59e-5)" "unprognostic (1.18e-2)" "unprognostic (9.97e-2)" "unprognostic (4.21e-2)" "unprognostic (7.06e-2)" 9.4 10.5 18.9 6.8 20.6 3.4 9.6 23.5 29.3 9.4 9.1 16.5 22.1 12.0 2.1 9.2 11.6 3.1 7.3 25.9 19.4 23.1 31.8 8.5 5.9 36.0 30.5 15.5 8.9 7.4 16.5 2.2 37.2 13.3 3.6 3.2 7.6 4.4 7.8 4.8 18.9 2.6 21.2 11.4 14.8 24.1 30.6 5.3 16.0 3.1 3.1 10.7 7.3 26.1 8.4 22.3 8.2 15.3 8.5 3.6 16.3 8.5 6.8 9.3 11.1 39.8 10.4 15.0 5.9 5.3 5.6 6.4 7.5 6.9 1.3 17.5 19.4 16.9 11.5 13.7 13.5 11.1 17.3 6.5 3.6 6.5 4.4 4.4 5.2 20.9 11.7 12.5 4.7 8.3 27.2 64.7 11.2 6.0 10.7 23.3 6.5 10.0 4.3 5.3 29.3 23.1 8.3 12.7 8.3 4.5 7.1 6.9 8.5 13.6 7.7 10.9 17.1 24.5 31.0 16.4 7.9 12.2 12.6 11.7 6.2 2.9 4.3 7.1 4.0 5.0 3.4 4.2 5.5 8.6 4.8 4.8 2.4 5.6 6.2 5.4 3.7 3.5 18.9 20.6 23.5 29.3 25.9 19.4 36.0 30.5 37.2 21.2 30.6 26.1 3.7 6.4 7.7 8.5 13.3 3.3 5.7 5.6 4.6 68.5 6.8 6.5 1.5 12.8 6.2 11.0 77.2 6.8 13.6 20.6 1.9 6.2 11.0 6.2 6.1 6.5 16.2 2.1 9.1 5.0 6.3 5.3 15.3 6.9 4.5 14.5 6.4 19.8 8.3 45.4 11.2 11.3 4.1 12.3 7.3 18.4 16.4 6.5 3.6 6.5 11.4 20.8 33.0 6.0 11.9 6.8 16.7 12.8 7.1 6.2 44.2 18.6 4.9 79.9 6.6 6.3 5.4 18.1 6.3 7.3 2.8 4.5 12.3 8.9 17.3 4.3 SPTLC1 "hLCB1, HSAN1, HSN1, LCB1, SPTI" ENSG00000090054 "Serine palmitoyltransferase long chain base subunit 1" O15269 9 92000087-92115413 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins" "Lipid metabolism, Sphingolipid metabolism" "Acyltransferase, Transferase" "Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 94.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA010860, CAB018747, HPA063907" Supported Supported "Endoplasmic reticulum" NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 1: Thyroid gland - Transcription" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 7: Non-specific - Mitochondria" "Endoplasmic reticulum" "CAB018747: AB_2195864, HPA010860: AB_1080086, HPA063907: AB_2685148" "unprognostic (1.22e-1)" "unprognostic (1.75e-2)" "unprognostic (1.47e-1)" "unprognostic (3.51e-2)" "unprognostic (1.54e-1)" "unprognostic (1.23e-2)" "unprognostic (3.03e-2)" "unprognostic (4.22e-3)" "unprognostic (1.27e-1)" "unprognostic (4.06e-1)" "unprognostic (3.55e-3)" "unprognostic (8.37e-2)" "prognostic favorable (1.36e-6)" "unprognostic (1.13e-1)" "unprognostic (2.41e-2)" "unprognostic (4.28e-1)" "unprognostic (1.49e-1)" 35.6 32.6 24.0 27.3 27.0 23.3 44.1 26.0 34.2 43.1 28.6 42.3 34.7 40.4 41.3 54.3 36.7 34.1 21.5 24.3 26.6 42.8 23.4 33.6 25.7 27.8 27.5 43.8 26.5 48.0 17.3 42.4 28.0 32.9 44.1 19.8 31.3 28.1 14.2 41.3 37.9 31.4 27.9 26.3 37.1 26.5 25.6 25.9 53.0 18.6 34.4 37.2 34.7 31.6 73.0 48.8 46.8 41.6 120.0 92.0 78.4 74.7 94.2 65.3 66.3 31.5 150.7 38.6 45.1 93.9 78.3 198.4 49.7 68.1 73.0 39.8 36.1 36.7 32.7 51.7 80.5 65.5 49.9 82.6 92.6 68.0 74.8 72.3 62.5 43.5 83.8 46.6 91.1 69.6 34.7 47.6 67.5 97.4 57.9 39.4 58.7 33.3 84.1 37.9 35.0 37.2 104.4 81.1 61.3 62.4 39.2 54.2 72.3 58.8 48.0 73.9 56.8 33.2 44.4 23.9 74.2 39.3 79.4 32.4 33.1 20.2 16.7 36.1 17.0 15.4 18.0 17.4 30.6 15.5 21.4 16.6 33.3 18.5 34.2 18.4 25.7 25.5 24.0 27.0 26.0 34.2 24.3 26.6 27.8 27.5 28.0 27.9 25.6 31.6 40.7 38.5 38.3 27.7 22.1 10.6 13.6 14.5 26.2 6.9 33.2 20.6 4.1 4.3 25.9 36.8 14.6 12.7 24.4 8.0 9.8 53.4 94.8 34.7 42.5 23.1 2.4 7.2 35.3 56.4 15.6 32.3 13.7 47.4 24.6 26.9 6.1 4.3 11.0 6.7 32.5 7.2 12.2 5.7 10.3 26.1 6.2 24.6 12.4 20.6 22.0 13.7 7.2 36.7 52.1 60.8 7.1 6.0 26.2 9.8 11.7 28.5 28.0 8.7 13.1 12.1 23.5 35.3 25.9 27.6 9.1 21.8 21.9 33.2 6.9 14.5 SPTLC2 "hLCB2a, KIAA0526, LCB2, LCB2A" ENSG00000100596 "Serine palmitoyltransferase long chain base subunit 2" O15270 14 77505997-77616637 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins" "Lipid metabolism, Sphingolipid metabolism" "Acyltransferase, Transferase" "Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 164.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA No "Cluster 14: Monocytes - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 36: HEL - Hemostasis" "Cluster 10: Non-specific - Unknown function" "unprognostic (3.16e-1)" "unprognostic (2.82e-2)" "unprognostic (1.24e-1)" "unprognostic (4.41e-2)" "unprognostic (2.12e-1)" "unprognostic (1.42e-1)" "prognostic unfavorable (3.62e-4)" "unprognostic (1.46e-2)" "unprognostic (3.09e-1)" "unprognostic (4.05e-1)" "unprognostic (1.98e-2)" "unprognostic (2.51e-1)" "prognostic favorable (6.69e-8)" "unprognostic (1.29e-2)" "unprognostic (2.35e-1)" "unprognostic (4.94e-2)" "unprognostic (1.32e-1)" 17.6 12.2 14.6 12.6 26.7 33.7 18.3 24.0 19.4 15.2 9.9 18.5 14.5 10.5 7.6 22.8 14.2 11.8 6.7 15.3 18.1 17.6 7.7 13.1 12.0 30.7 21.5 10.4 5.7 10.7 6.2 20.4 31.5 8.4 19.8 14.2 13.7 8.8 3.9 12.2 17.4 11.6 25.3 19.6 20.4 5.0 21.7 10.3 10.9 6.1 13.3 15.0 10.8 52.7 28.9 18.5 14.1 15.5 14.3 17.8 23.7 41.7 30.8 28.2 29.3 23.7 62.3 28.8 10.4 42.7 14.5 34.7 38.1 23.7 42.5 12.6 11.0 82.5 13.4 14.3 12.1 8.4 25.8 11.7 11.4 18.4 20.4 16.3 40.6 19.4 16.2 13.5 16.2 24.9 22.2 28.7 9.2 45.4 16.8 23.5 14.3 10.0 32.9 63.4 13.6 17.1 15.0 50.3 15.8 24.7 61.8 15.3 25.9 25.7 18.2 9.6 9.7 7.6 13.4 19.1 17.3 29.4 14.8 18.3 31.3 27.1 6.1 24.2 5.7 6.7 5.1 6.8 31.2 7.9 3.5 5.8 19.1 17.7 31.8 11.1 6.0 13.4 14.6 26.7 24.0 19.4 15.3 18.1 30.7 21.5 31.5 25.3 21.7 52.7 125.1 28.9 27.3 24.8 27.3 32.4 28.3 27.0 15.4 15.7 24.3 18.4 8.9 15.7 30.7 47.8 35.5 11.9 28.3 37.6 1.9 24.0 1.6 44.1 36.0 53.1 13.2 51.3 31.2 16.1 12.3 18.9 43.3 36.0 51.3 37.2 68.2 7.2 25.1 5.0 29.5 39.3 20.3 75.9 19.8 1.7 14.6 66.2 19.6 83.4 51.3 8.8 32.0 59.3 164.0 35.0 30.4 15.8 11.0 27.0 28.4 8.8 33.5 20.0 32.9 10.5 25.5 7.3 19.0 37.7 29.1 6.6 23.3 14.6 33.0 60.0 SPTLC3 "C20orf38, FLJ11112, hLCB2b, LCB2B, SPTLC2L" ENSG00000172296 "Serine palmitoyltransferase long chain base subunit 3" Q9NUV7 20 13008972-13169103 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Lipid metabolism, Sphingolipid metabolism" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 28.4;Early spermatids: 27.9;Glandular and luminal cells: 47.4;Microglial cells: 35.6;Syncytiotrophoblasts: 46.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "NK-cell: 1.5" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "Karpas-707: 33.3;RPTEC TERT1: 43.7;U-2197: 30.4;U-87 MG: 57.3" "Low region specificity" "Detected in some" "Low region specificity" "Detected in many" "HPA044247, HPA048079" Enhanced Approved Microtubules NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 1: Thyroid gland - Transcription" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 44: Endometrium - Transcription" Microtubules "HPA044247: AB_2678872, HPA048079: AB_2680252" "unprognostic (6.81e-2)" "unprognostic (7.76e-2)" "unprognostic (4.46e-2)" "unprognostic (1.25e-3)" "unprognostic (5.43e-2)" "unprognostic (2.12e-1)" "unprognostic (5.70e-2)" "unprognostic (7.99e-2)" "unprognostic (9.51e-2)" "unprognostic (2.21e-1)" "prognostic unfavorable (6.02e-4)" "unprognostic (5.08e-2)" "prognostic favorable (4.51e-7)" "unprognostic (2.80e-2)" "unprognostic (1.01e-1)" "unprognostic (1.17e-1)" "unprognostic (3.18e-1)" 4.6 4.3 1.4 1.4 1.4 0.6 8.3 1.2 1.3 7.4 8.5 6.1 15.7 4.7 16.8 5.9 6.7 10.9 6.4 1.5 2.7 18.2 20.0 7.8 1.3 2.4 2.1 7.1 5.6 11.0 2.7 20.9 2.4 5.9 7.4 2.8 6.7 3.6 0.4 25.6 16.2 3.9 1.8 2.9 4.5 6.4 3.8 5.0 24.4 2.0 1.7 5.7 5.1 2.5 1.5 2.4 1.8 0.0 14.1 20.2 11.4 0.0 3.2 2.1 8.2 18.6 9.3 0.0 1.2 0.6 18.2 25.0 0.0 7.0 3.0 0.0 0.1 0.0 5.6 26.4 1.3 0.0 0.2 11.5 21.4 8.4 2.8 7.7 1.4 4.4 0.0 33.3 23.7 0.5 0.1 0.0 0.1 2.2 2.9 2.3 4.2 15.1 43.7 18.2 0.0 0.3 0.2 2.3 0.1 3.1 18.6 0.5 3.3 9.2 3.1 30.4 2.2 0.2 0.0 0.0 57.3 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.9 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 1.5 0.0 0.0 0.0 0.0 1.4 1.4 1.2 1.3 1.5 2.7 2.4 2.1 2.4 1.8 3.8 2.5 3.6 6.4 22.3 5.2 0.1 2.4 5.3 2.3 4.6 0.1 5.4 5.0 17.9 4.3 4.9 9.2 0.0 28.4 1.0 3.4 7.9 3.0 27.9 18.7 5.2 4.6 0.0 2.1 0.5 4.4 13.0 5.4 4.6 47.4 1.3 5.6 1.8 20.7 2.8 0.0 0.9 5.7 6.1 2.6 0.4 11.6 3.7 2.4 0.0 35.6 0.0 12.3 3.1 0.0 0.1 3.2 6.7 2.6 0.1 2.3 10.9 18.6 3.5 0.4 0.0 6.1 0.8 1.2 0.1 4.9 2.3 46.1 1.2 2.9 7.3 2.6 SRC "ASV, c-src, SRC1" ENSG00000197122 "SRC proto-oncogene, non-receptor tyrosine kinase" P12931 20 37344685-37406050 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters" "Cell adhesion, Cell cycle, Host-virus interaction, Immunity" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal enterocytes: 42.0;Gastric mucus-secreting cells: 43.8;Langerhans cells: 46.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in some" "intermediate monocyte: 2.4;non-classical monocyte: 2.3" "Group enriched" "Detected in many" 6 "dendritic cells: 1.4;monocytes: 2.4" "Cell line enhanced" "Detected in many" "A549: 110.8;HBEC3-KT: 102.6;RT4: 106.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004023, HPA030875" Approved Supported "Nucleoplasm,Plasma membrane,Cell Junctions,Cytosol" NA NA 3200000 "Cluster 51: Monocytes - Innate immune response" "Cluster 71: Testis - DNA repair" "Cluster 15: RT4 - Unknown function" "Cluster 27: Mucus-secreting cells - Mucin production" "Plasma membrane, Cell Junctions" "Nucleoplasm, Cytosol" "CAB004023: AB_2106059, HPA030875: AB_2673640" "unprognostic (5.58e-2)" "unprognostic (9.83e-2)" "unprognostic (3.56e-1)" "unprognostic (4.54e-3)" "unprognostic (1.52e-1)" "unprognostic (1.54e-2)" "prognostic unfavorable (4.90e-5)" "unprognostic (3.89e-2)" "unprognostic (7.04e-2)" "unprognostic (8.13e-2)" "unprognostic (1.54e-2)" "prognostic unfavorable (1.63e-4)" "prognostic unfavorable (1.22e-4)" "unprognostic (2.33e-2)" "unprognostic (4.72e-2)" "unprognostic (3.65e-2)" "prognostic favorable (5.22e-5)" 9.7 25.3 5.7 13.3 5.2 8.4 10.1 0.4 6.2 25.1 1.5 30.3 39.8 31.9 3.2 26.1 23.8 27.9 8.8 6.4 5.5 21.4 4.3 16.1 6.3 2.6 3.4 23.6 30.8 11.1 15.9 8.1 2.2 30.8 17.1 5.5 11.8 27.4 2.4 13.0 38.8 17.2 1.7 14.2 39.9 25.2 5.0 6.1 9.8 1.5 8.1 35.6 24.6 3.0 24.6 110.8 24.9 22.6 9.3 14.7 51.6 22.0 18.9 26.3 16.6 41.9 21.5 0.7 13.4 40.2 29.9 43.5 15.1 102.6 10.3 0.1 13.7 6.2 3.9 65.9 22.0 0.3 9.3 15.7 34.2 17.3 22.8 29.4 24.3 14.2 0.6 0.2 4.4 16.7 6.0 0.8 11.7 67.3 98.8 26.5 6.6 0.7 11.0 106.3 23.1 83.6 25.0 34.5 27.2 19.1 31.1 9.0 35.8 31.4 20.9 11.7 20.1 0.3 0.8 0.3 22.1 0.1 24.0 0.0 1.6 0.0 0.0 2.4 0.0 0.1 0.0 0.0 0.5 0.1 0.0 0.0 0.0 0.3 2.3 1.4 0.0 1.0 5.7 5.2 0.4 6.2 6.4 5.5 2.6 3.4 2.2 1.7 5.0 3.0 1.0 3.2 1.7 3.3 4.1 8.2 12.5 9.5 10.8 6.5 6.2 7.5 2.2 18.6 4.7 12.9 2.1 2.3 4.9 42.0 1.9 12.2 1.8 6.4 10.7 1.4 16.8 0.4 9.5 18.7 8.3 7.2 43.8 12.4 0.0 14.8 1.1 1.6 5.7 3.3 9.1 29.2 8.2 9.4 46.3 3.3 10.8 22.8 1.8 9.4 9.7 4.4 1.0 9.0 0.6 39.1 19.2 17.3 4.3 18.0 36.7 9.3 5.6 5.2 13.1 1.8 6.7 0.3 1.1 11.2 9.1 2.3 1.0 2.9 16.9 36.6 SRM "SPS1, SRML1" ENSG00000116649 "Spermidine synthase" P19623 1 11054584-11060020 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Polyamine biosynthesis, Spermidine biosynthesis" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Plasma cells: 371.7;Prostatic glandular cells: 249.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA015746 Approved Approved Nucleoplasm,Cytosol NA NA 26000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 50: Non-specific - Ribosome" "Cluster 25: RPMI-8226 - Immune response" "Cluster 55: Plasma cells - Humoral immune response" Nucleoplasm Cytosol "HPA015746: AB_1857472" "unprognostic (4.97e-2)" "unprognostic (1.55e-1)" "unprognostic (1.80e-1)" "unprognostic (2.52e-2)" "unprognostic (1.75e-1)" "unprognostic (1.97e-1)" "prognostic unfavorable (2.25e-5)" "unprognostic (2.11e-2)" "unprognostic (2.44e-1)" "unprognostic (3.58e-2)" "unprognostic (3.01e-1)" "unprognostic (3.45e-1)" "prognostic unfavorable (3.80e-8)" "unprognostic (1.74e-2)" "unprognostic (8.98e-3)" "unprognostic (1.36e-1)" "unprognostic (2.98e-2)" 77.5 69.5 53.9 54.3 54.8 31.5 64.5 45.9 71.1 58.1 45.4 56.2 19.1 68.7 16.0 63.9 57.8 18.7 89.5 57.1 52.5 43.3 77.5 53.7 44.4 49.4 58.9 60.6 190.8 15.1 53.4 26.0 51.8 50.1 19.8 10.2 52.4 28.7 127.1 54.2 40.1 40.8 49.0 70.7 57.6 33.0 57.9 24.2 34.4 48.3 38.2 74.5 48.6 47.5 149.6 212.1 69.1 232.5 134.8 144.6 107.7 224.9 114.7 315.1 168.1 263.5 87.4 284.3 127.8 197.2 98.8 114.0 222.6 181.6 104.2 140.5 337.0 180.1 225.3 302.0 197.7 305.6 157.6 145.9 129.1 306.0 266.0 73.8 134.8 183.2 298.1 234.7 155.8 326.5 261.7 266.3 150.5 136.0 405.4 194.6 71.3 466.2 112.4 58.3 132.3 126.5 116.8 248.4 182.3 53.1 87.1 153.2 113.4 204.3 161.7 357.5 257.1 185.6 201.7 429.6 142.4 406.2 241.2 0.0 5.9 0.4 7.4 6.8 10.8 12.5 7.2 9.3 7.0 11.3 8.5 10.0 0.2 5.7 3.5 11.2 8.8 2.3 53.9 54.8 45.9 71.1 57.1 52.5 49.4 58.9 51.8 49.0 57.9 47.5 68.5 0.0 4.6 4.9 115.2 95.0 92.6 6.9 18.2 27.4 75.7 165.7 31.7 28.6 4.0 29.5 20.9 78.0 44.9 23.0 76.3 20.0 4.1 11.0 97.9 54.5 27.5 67.9 13.9 43.2 198.4 91.8 36.2 16.6 26.7 102.0 35.0 50.5 96.4 30.3 23.0 39.9 6.1 41.2 41.7 14.7 71.7 39.8 67.6 10.3 22.4 44.0 29.9 15.6 9.6 30.4 10.8 53.0 371.7 249.9 3.5 86.0 2.5 18.3 0.0 70.7 66.3 14.1 75.9 47.8 113.1 36.0 49.5 108.3 43.1 95.5 SRMS "C20orf148, dJ697K14.1, PTK70, SRM" ENSG00000125508 "Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites" Q9H3Y6 20 63540810-63547504 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "stomach 1: 1.6" "Cell type enriched" "Detected in single" 4 "Gastric mucus-secreting cells: 3.6" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "CAPAN-2: 3.3;MCF7: 3.0;OE19: 4.4;RT4: 6.0" "Not detected" "Not detected" "Not detected" "Not detected" "CAB044668, CAB044669, HPA073987" Uncertain Approved "Intermediate filaments,Actin filaments,Cytosol" No NA "Cluster 24: Salivary gland - Salivary secretion" "Cluster 21: OE19 - Mitochondria" "Cluster 43: Cardiomyocytes - Nuclear processes" "Intermediate filaments" "Actin filaments, Cytosol" "CAB044668: AB_10609403, CAB044669: AB_10608235, HPA073987: AB_2686650" "unprognostic (2.26e-2)" "unprognostic (1.26e-2)" "unprognostic (2.52e-3)" "unprognostic (8.32e-2)" "unprognostic (2.62e-1)" "unprognostic (5.47e-3)" "unprognostic (1.65e-1)" "unprognostic (2.28e-1)" "unprognostic (9.63e-2)" "unprognostic (6.48e-3)" "unprognostic (7.28e-3)" "unprognostic (1.46e-1)" "unprognostic (1.73e-3)" "unprognostic (2.58e-3)" "unprognostic (4.75e-2)" "unprognostic (4.97e-2)" "unprognostic (2.54e-3)" 0.0 0.0 0.1 0.2 0.1 0.1 0.4 0.6 0.2 0.0 0.0 0.7 0.2 0.0 0.7 0.1 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.1 0.0 0.0 1.0 0.0 0.0 0.0 0.1 0.8 0.0 0.0 0.8 0.0 0.0 0.4 0.2 0.0 0.1 0.9 1.6 0.2 0.1 0.0 0.1 0.0 0.1 0.3 0.0 0.6 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 3.3 0.1 1.3 0.0 0.0 1.5 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 3.0 0.0 0.1 0.0 4.4 0.4 0.0 0.1 0.0 0.0 6.0 0.4 0.5 0.1 1.2 0.2 0.0 1.5 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.6 0.2 0.0 0.0 0.1 0.0 0.1 0.1 0.1 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 SRPK1 SFRSK1 ENSG00000096063 "SRSF protein kinase 1" Q96SB4 6 35832966-35921342 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Chromosome partition, Differentiation, Host-virus interaction, mRNA processing, mRNA splicing" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 379.9;Late spermatids: 599.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 61.0" "Lineage enriched" "Detected in all" 4 "granulocytes: 61.0" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016431, HPA056486" Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 31: Spermatids - Spermatogenesis" "Nucleoplasm, Cytosol" "Plasma membrane" "HPA016431: AB_1857478, HPA056486: AB_2683148" "unprognostic (4.65e-3)" "unprognostic (6.82e-3)" "unprognostic (2.54e-3)" "unprognostic (1.01e-3)" "unprognostic (7.74e-2)" "unprognostic (3.31e-2)" "prognostic unfavorable (7.90e-6)" "unprognostic (1.23e-2)" "unprognostic (2.54e-3)" "unprognostic (2.36e-2)" "prognostic unfavorable (6.53e-5)" "unprognostic (7.28e-2)" "unprognostic (2.21e-3)" "unprognostic (9.24e-2)" "unprognostic (4.43e-1)" "unprognostic (1.01e-1)" "unprognostic (7.55e-3)" 8.7 6.0 6.4 18.1 8.2 41.7 14.5 10.0 14.8 12.5 6.8 31.2 25.2 12.7 9.3 23.9 8.6 11.9 8.3 8.9 3.7 16.7 16.0 12.9 19.7 4.0 4.1 8.7 23.3 14.5 9.0 14.5 4.3 9.6 35.6 25.8 16.1 10.9 20.0 26.7 23.6 14.2 2.4 17.8 18.0 44.7 5.2 19.9 8.7 12.6 24.3 31.0 16.2 11.6 104.1 39.2 54.9 82.4 30.2 39.3 69.0 62.1 60.1 57.3 60.2 109.0 34.1 139.0 51.8 39.1 65.5 51.3 110.3 74.2 100.6 96.2 79.9 73.5 42.6 93.8 26.7 111.3 34.0 25.6 39.3 66.0 84.7 44.6 72.3 76.4 157.7 55.6 48.2 36.8 111.1 80.8 45.9 62.9 42.7 77.8 67.3 84.1 56.8 169.5 117.5 42.9 65.4 59.3 42.5 55.2 33.3 70.3 54.8 52.4 41.3 37.2 78.6 33.1 78.6 128.5 20.9 124.3 48.1 61.0 4.4 30.6 8.5 5.3 12.1 8.6 11.2 11.5 5.9 6.9 9.2 10.0 50.9 11.2 7.6 3.3 14.9 6.3 6.4 8.2 10.0 14.8 8.9 3.7 4.0 4.1 4.3 2.4 5.2 11.6 26.6 9.6 25.8 18.6 40.0 42.3 119.3 91.0 67.7 36.8 25.8 22.7 28.7 14.3 51.4 22.0 37.5 54.3 33.1 51.6 29.4 55.4 379.9 29.9 40.2 29.2 46.2 46.7 74.2 68.2 53.2 25.1 46.9 54.0 7.6 44.1 13.2 41.8 21.6 10.1 50.0 50.8 32.6 16.3 19.9 599.1 22.1 20.0 16.0 24.4 31.5 16.8 32.0 30.2 29.7 100.4 47.9 24.8 68.0 117.9 50.8 59.4 33.8 92.9 6.6 17.8 48.9 197.3 100.4 126.8 41.8 39.7 43.6 33.7 90.7 162.6 SRPK2 SFRSK2 ENSG00000135250 "SRSF protein kinase 2" P78362 7 105110704-105399308 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Differentiation, mRNA processing, mRNA splicing" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 108.2" "Group enriched" "Detected in all" 4 "Early spermatids: 1275.7;Late spermatids: 2280.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 219.5" "Lineage enriched" "Detected in all" 5 "granulocytes: 219.5" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015522, HPA020876" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 78: Testis - Spermatogenesis" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoplasm, Cytosol" "HPA015522: AB_1857479, HPA020876: AB_1857480" "unprognostic (9.75e-2)" "unprognostic (1.68e-2)" "unprognostic (1.12e-1)" "unprognostic (4.64e-2)" "unprognostic (3.54e-1)" "unprognostic (1.30e-1)" "unprognostic (5.14e-2)" "unprognostic (1.54e-1)" "unprognostic (2.28e-2)" "unprognostic (1.92e-1)" "unprognostic (2.19e-1)" "unprognostic (2.31e-1)" "unprognostic (5.38e-2)" "unprognostic (7.95e-2)" "unprognostic (4.72e-2)" "unprognostic (2.87e-2)" "unprognostic (3.44e-1)" 14.3 16.2 27.2 15.0 29.7 10.7 18.3 20.1 46.8 16.3 0.0 13.3 11.4 18.1 15.8 16.4 14.6 16.0 14.7 31.0 30.0 13.8 14.2 12.8 17.9 27.9 25.5 17.3 14.7 15.1 12.9 17.1 30.4 18.8 14.8 24.2 15.1 14.4 11.3 24.4 11.4 18.3 19.3 17.8 16.3 108.2 26.7 41.4 15.5 11.8 20.6 18.2 11.6 47.1 36.9 24.0 37.3 74.5 39.3 43.8 21.0 35.4 40.8 34.5 39.9 18.9 30.5 23.4 43.7 45.8 38.5 21.6 38.3 37.3 43.7 40.5 33.2 33.1 21.8 16.5 45.1 31.8 47.1 30.6 67.5 29.2 54.6 33.0 59.8 54.4 33.0 92.2 38.5 69.3 118.3 23.9 31.1 20.8 25.9 37.9 41.3 51.1 49.5 56.1 54.8 37.8 40.1 59.0 37.7 49.1 22.1 21.8 39.7 62.9 45.9 60.8 33.4 100.6 106.6 56.5 24.8 32.3 48.1 50.3 30.2 103.3 41.4 21.0 24.8 45.0 31.1 31.6 27.3 44.0 29.3 33.6 219.5 38.7 25.1 23.6 38.6 25.2 27.2 29.7 20.1 46.8 31.0 30.0 27.9 25.5 30.4 19.3 26.7 47.1 35.8 28.9 29.5 128.9 62.9 212.9 60.6 68.1 49.5 76.9 45.2 40.0 23.3 28.6 41.5 23.9 50.1 52.4 87.1 16.6 27.4 52.9 1275.7 54.3 41.9 51.8 28.8 17.2 298.1 46.3 35.6 47.3 40.8 51.6 41.2 48.9 53.6 35.9 47.6 124.5 300.9 35.2 54.9 43.0 42.9 2280.6 76.7 39.2 58.7 168.6 57.0 73.7 103.0 172.4 399.8 36.4 24.4 95.9 54.8 100.7 15.7 25.9 54.2 67.6 46.0 40.3 59.1 198.8 66.0 36.7 103.3 64.4 58.2 61.4 26.1 67.9 SRPK3 "MSSK1, STK23" ENSG00000184343 "SRSF protein kinase 3" Q9UPE1 X 153776412-153785732 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Differentiation, Myogenesis" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "skeletal muscle: 211.4;tongue: 76.8" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 25.0;Cone photoreceptor cells: 8.4;Oligodendrocytes: 7.4;Skeletal myocytes: 18.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "RH-30: 47.0;U-266/70: 19.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 37: Myocytes - Muscle contraction" "unprognostic (1.79e-3)" "unprognostic (6.21e-2)" "unprognostic (1.79e-2)" "unprognostic (7.24e-2)" "unprognostic (1.44e-1)" "unprognostic (2.51e-1)" "unprognostic (1.97e-1)" "unprognostic (4.47e-4)" "unprognostic (2.83e-1)" "unprognostic (1.71e-1)" "unprognostic (4.10e-4)" "unprognostic (8.70e-2)" "unprognostic (5.38e-7)" "unprognostic (1.97e-2)" "unprognostic (1.97e-1)" "unprognostic (3.83e-2)" "unprognostic (1.07e-4)" 1.6 4.3 12.5 2.2 15.8 2.1 1.4 20.2 19.2 3.2 8.7 17.0 3.3 8.4 1.6 6.5 2.9 1.5 47.3 12.2 12.8 1.6 0.7 1.1 2.2 14.6 14.3 2.3 1.6 1.4 18.7 0.5 14.5 7.8 1.7 1.7 7.6 1.1 211.4 5.7 3.9 3.1 11.4 1.9 5.0 1.1 16.0 0.3 0.6 76.8 0.1 6.7 2.7 23.4 5.1 6.7 1.2 3.3 0.0 0.2 1.5 0.6 0.0 0.3 0.1 5.7 0.9 5.1 0.6 0.6 0.5 1.4 0.0 0.1 0.0 4.4 4.6 2.7 5.1 0.9 0.1 1.3 7.6 4.1 0.0 0.0 0.0 0.3 0.0 7.1 3.5 5.8 1.3 10.8 1.0 7.5 1.2 0.3 1.8 2.3 47.0 1.5 0.1 2.3 8.0 3.8 0.0 3.5 1.6 0.5 4.4 5.8 0.1 1.8 4.2 3.5 0.7 19.4 3.5 3.3 1.0 9.5 2.5 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.4 0.0 0.0 12.5 15.8 20.2 19.2 12.2 12.8 14.6 14.3 14.5 11.4 16.0 23.4 0.1 0.0 0.0 3.3 0.0 0.6 1.0 0.1 0.0 4.3 2.5 1.0 25.0 0.0 0.1 0.0 8.4 0.0 0.0 0.4 0.0 0.1 0.0 0.6 0.2 0.5 1.2 0.0 0.7 0.0 0.1 1.1 1.5 0.2 0.0 0.2 0.0 0.0 0.0 1.7 1.8 4.0 0.0 0.0 0.2 0.2 0.3 0.1 0.0 0.0 0.1 0.5 0.0 0.5 7.4 0.0 0.0 3.0 0.2 0.7 0.0 0.0 0.1 0.5 0.0 18.9 2.0 0.0 0.2 0.0 0.4 0.0 0.0 0.2 0.6 0.4 ST3GAL1 "SIAT4A, SIATFL, ST3GalA.1, ST3O" ENSG00000008513 "ST3 beta-galactoside alpha-2,3-sialyltransferase 1" Q11201 8 133454848-133571940 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Lipid metabolism" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Hepatocytes: 159.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "OE19: 75.9;PC-3: 131.8;RT4: 102.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040466 Approved "Intracellular and membrane" NA NA 860000 "Cluster 2: Granulocytes - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 21: OE19 - Mitochondria" "Cluster 24: Non-specific - Transcription regulation" "HPA040466: AB_10805712" "unprognostic (1.36e-2)" "unprognostic (1.11e-2)" "unprognostic (6.66e-2)" "unprognostic (1.83e-3)" "unprognostic (5.53e-3)" "unprognostic (4.43e-2)" "unprognostic (4.79e-2)" "unprognostic (2.66e-1)" "unprognostic (1.97e-1)" "unprognostic (1.04e-1)" "unprognostic (3.55e-3)" "unprognostic (1.10e-1)" "unprognostic (1.83e-3)" "unprognostic (1.67e-2)" "unprognostic (3.29e-2)" "unprognostic (8.64e-3)" "unprognostic (2.95e-2)" 25.7 22.5 8.8 22.8 8.6 22.6 12.2 5.3 9.4 11.4 12.3 6.5 3.6 11.6 12.7 14.0 15.5 19.0 53.1 9.6 6.3 44.5 67.7 19.2 23.1 7.9 11.2 13.3 15.4 10.9 9.9 13.8 6.9 8.0 5.5 10.0 24.9 10.2 43.8 5.9 9.9 10.6 7.2 21.2 16.1 4.3 7.4 17.4 66.1 49.3 21.6 34.4 10.9 7.2 14.0 6.6 3.0 8.3 28.6 15.0 14.4 15.4 35.5 5.7 4.4 13.3 15.1 3.3 10.3 28.2 2.7 4.2 9.4 11.3 4.9 37.6 1.7 28.4 22.5 25.4 22.0 5.9 22.1 17.8 5.7 19.5 11.7 27.2 26.4 7.5 0.5 42.5 4.4 14.9 8.4 8.0 2.1 75.9 131.8 9.9 3.7 24.3 2.7 102.2 0.7 2.0 6.8 23.3 6.9 15.4 4.3 8.1 26.3 18.3 28.5 15.7 6.9 53.0 39.3 3.6 41.7 19.8 18.5 47.8 8.8 41.7 24.1 8.1 22.9 22.7 25.2 28.3 5.3 38.6 34.4 32.4 16.1 43.2 20.4 12.6 17.2 18.9 8.8 8.6 5.3 9.4 9.6 6.3 7.9 11.2 6.9 7.2 7.4 7.2 29.4 6.4 56.8 38.2 68.4 5.7 14.4 14.8 21.1 13.4 13.7 8.4 63.2 12.8 22.2 1.8 2.1 9.7 65.5 4.6 5.9 41.3 3.4 8.9 29.2 44.3 0.0 38.5 36.7 25.4 53.5 47.8 10.7 28.1 8.8 12.1 37.9 159.8 37.8 60.6 34.6 0.6 16.2 52.5 29.0 2.1 36.7 48.8 14.2 49.6 59.8 11.5 47.4 5.0 2.4 39.4 0.0 71.8 29.1 10.9 0.0 48.5 6.5 23.3 13.1 28.1 23.6 0.2 2.8 30.0 3.4 26.4 79.9 6.5 0.3 43.6 ST3GAL2 "SIAT4B, ST3GalA.2, ST3GALII" ENSG00000157350 "ST3 beta-galactoside alpha-2,3-sialyltransferase 2" Q16842 16 70375977-70439237 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid metabolism" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "dendritic cells: 56.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "HMC-1: 29.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017270 Approved Uncertain Vesicles "Intracellular and membrane" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 72: Non-specific - Transcription" "Cluster 1: K-562 - Erythropoiesis" "Cluster 65: Plasmacytoid DCs - Unknown function" Vesicles "HPA017270: AB_1857523" "unprognostic (2.76e-2)" "unprognostic (6.33e-2)" "unprognostic (3.41e-1)" "unprognostic (1.35e-1)" "unprognostic (4.99e-1)" "unprognostic (1.01e-1)" "prognostic unfavorable (2.79e-4)" "unprognostic (1.14e-2)" "unprognostic (2.21e-1)" "unprognostic (1.91e-2)" "prognostic favorable (2.33e-4)" "unprognostic (9.54e-2)" "prognostic unfavorable (3.34e-6)" "unprognostic (7.42e-2)" "unprognostic (8.83e-3)" "unprognostic (4.64e-2)" "unprognostic (5.20e-2)" 8.6 8.3 4.7 6.4 5.8 7.4 7.2 8.4 6.5 9.3 1.6 9.2 3.5 12.5 1.1 2.6 8.2 2.5 10.5 7.1 2.9 8.2 10.3 9.0 6.3 3.1 2.6 7.2 3.6 2.6 6.4 3.2 2.6 7.1 1.6 1.7 3.2 2.8 15.8 4.2 7.1 4.1 1.9 13.2 4.7 6.7 3.3 3.6 6.0 3.1 3.4 8.4 5.6 2.9 1.7 8.6 7.7 11.2 3.9 5.4 2.3 6.1 6.0 6.2 3.0 5.5 4.0 4.6 9.8 6.3 5.8 1.9 3.2 2.5 3.3 9.9 5.0 18.0 4.5 8.7 4.7 6.7 29.4 4.1 1.5 6.7 1.3 8.2 8.6 7.6 25.1 4.2 3.7 1.5 7.5 19.8 10.1 2.9 4.5 13.9 2.9 5.9 5.1 1.5 3.7 9.4 15.8 0.6 7.1 8.1 2.4 7.3 9.9 9.0 10.0 4.0 4.7 8.6 3.9 9.7 10.0 5.9 12.5 4.2 1.9 5.2 2.0 1.8 1.7 2.0 2.3 2.0 1.0 2.9 3.8 3.0 10.1 2.8 1.3 14.3 2.6 1.1 4.7 5.8 8.4 6.5 7.1 2.9 3.1 2.6 2.6 1.9 3.3 2.9 15.4 9.6 5.2 13.4 12.6 3.3 4.2 2.1 2.2 15.7 2.8 3.0 6.8 10.0 1.9 9.2 14.6 4.7 56.1 4.5 0.0 5.7 16.9 1.7 6.5 15.0 13.2 24.8 21.3 4.4 2.5 11.0 2.6 2.2 17.7 19.7 18.2 13.1 13.7 18.5 15.2 4.5 2.0 15.4 35.1 33.2 11.8 11.9 1.8 17.8 24.9 5.6 23.7 16.6 7.4 1.8 1.5 8.2 13.5 3.0 6.8 5.7 1.3 11.1 6.6 8.5 8.8 9.3 8.9 1.1 2.4 1.8 11.5 4.7 5.6 2.3 ST3GAL3 "MRT12, SIAT6" ENSG00000126091 "ST3 beta-galactoside alpha-2,3-sialyltransferase 3" Q11203 1 43705824-43931165 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 88.0;tongue: 82.9" "Cell type enhanced" "Detected in many" "Astrocytes: 59.7;Excitatory neurons: 94.4;Granulosa cells: 52.5;Inhibitory neurons: 120.1;Microglial cells: 57.1;Oligodendrocyte precursor cells: 66.9;Oligodendrocytes: 66.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA051102 Uncertain "Intracellular and membrane" NA NA "Cluster 29: Plasmacytoid DCs - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 43: THP-1 - Innate immune response" "Cluster 40: Granulosa cells - Unknown function" "HPA051102: AB_2681344" "unprognostic (8.42e-2)" "unprognostic (1.38e-1)" "unprognostic (1.41e-2)" "unprognostic (5.18e-2)" "unprognostic (1.22e-1)" "unprognostic (3.20e-1)" "unprognostic (9.72e-2)" "unprognostic (7.01e-2)" "unprognostic (4.39e-2)" "unprognostic (2.33e-2)" "unprognostic (1.38e-3)" "unprognostic (7.00e-2)" "unprognostic (3.68e-3)" "unprognostic (1.67e-2)" "unprognostic (1.30e-1)" "unprognostic (4.35e-1)" "unprognostic (6.60e-2)" 12.9 14.7 28.5 5.0 27.3 11.0 11.0 30.8 32.5 14.6 22.8 19.4 2.6 16.7 9.8 8.3 12.8 6.9 26.1 27.2 29.4 9.9 13.5 8.7 6.1 27.9 29.0 14.9 8.0 6.7 17.8 6.5 29.2 13.2 4.4 24.5 8.3 13.3 88.0 7.0 6.6 13.1 23.2 7.6 9.6 22.6 30.8 4.9 8.4 82.9 3.7 16.7 10.1 28.1 4.3 2.7 23.4 11.0 17.4 21.9 3.0 15.5 30.8 14.1 13.7 2.6 6.6 7.0 8.6 19.0 7.7 3.8 2.8 10.2 15.7 8.7 5.8 15.0 10.6 7.5 14.7 6.6 7.1 12.1 7.4 9.7 21.3 26.1 12.1 18.4 8.8 13.1 25.3 2.7 7.0 11.7 9.2 1.0 8.1 11.4 3.3 6.1 11.0 2.4 9.3 13.8 5.5 2.5 14.1 9.6 3.5 30.3 10.4 8.3 3.9 13.3 15.4 10.4 6.1 6.9 11.7 15.7 15.3 1.7 2.1 1.2 3.3 1.1 2.9 2.2 2.1 2.5 1.5 2.8 3.5 2.6 2.4 2.2 1.9 3.3 2.9 3.3 28.5 27.3 30.8 32.5 27.2 29.4 27.9 29.0 29.2 23.2 30.8 28.1 6.7 6.4 19.3 59.7 6.6 3.3 3.0 4.1 5.7 9.4 4.6 3.3 34.5 1.5 3.8 3.7 0.0 3.1 2.7 2.2 5.9 2.6 19.4 2.4 6.6 7.6 2.4 8.4 94.4 2.4 1.6 9.0 1.5 2.8 24.1 52.5 4.6 8.6 3.1 18.5 120.1 1.4 4.1 2.2 3.1 14.5 3.7 4.5 3.6 57.1 3.6 6.1 5.2 66.9 66.2 2.7 0.2 11.7 4.2 2.2 0.1 6.3 4.9 17.8 19.7 5.8 9.8 8.5 5.1 2.7 1.3 1.0 6.0 15.7 1.7 10.0 ST3GAL4 "CGS23, FLJ11867, NANTA3, SAT3, SIAT4, SIAT4C, STZ" ENSG00000110080 "ST3 beta-galactoside alpha-2,3-sialyltransferase 4" Q11206 11 126355640-126440344 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Lipid metabolism" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Granulosa cells: 270.0;Paneth cells: 214.3;Syncytiotrophoblasts: 962.5" "Cancer enhanced" "Detected in all" "melanoma: 57.2" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 4 "basophil: 111.9;neutrophil: 71.8;plasmacytoid DC: 93.7" "Group enriched" "Detected in many" 12 "dendritic cells: 93.7;granulocytes: 111.9" "Cell line enhanced" "Detected in all" "SK-MEL-30: 234.7;WM-115: 515.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA049827 Approved "Intracellular and membrane" NA NA 15000 "Cluster 38: Basophils - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 17: WM-115 - Nervous system development" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" "HPA049827: AB_2680900" "unprognostic (8.89e-2)" "unprognostic (1.10e-2)" "unprognostic (4.92e-2)" "unprognostic (6.93e-2)" "unprognostic (8.33e-2)" "unprognostic (3.80e-2)" "unprognostic (2.71e-3)" "unprognostic (1.90e-3)" "unprognostic (2.62e-1)" "unprognostic (1.80e-2)" "unprognostic (1.57e-1)" "unprognostic (1.45e-1)" "unprognostic (3.16e-3)" "unprognostic (2.79e-2)" "unprognostic (1.28e-1)" "unprognostic (8.36e-3)" "unprognostic (8.78e-3)" 23.4 117.1 25.2 14.4 41.2 19.0 19.5 43.5 28.9 29.2 36.5 58.1 4.2 16.3 87.6 70.7 19.2 23.9 60.0 24.3 28.7 41.0 28.4 38.2 10.0 42.3 41.3 111.3 13.7 1.7 15.7 35.3 39.5 22.6 66.4 10.8 44.2 16.0 6.1 16.7 12.3 19.0 31.9 41.5 13.3 42.2 37.6 6.3 14.7 7.7 22.7 49.3 33.8 57.2 26.4 21.4 17.0 13.6 46.8 39.4 38.5 30.2 56.6 26.5 18.2 11.4 44.5 7.0 21.9 47.0 88.0 37.1 34.0 19.2 20.0 27.7 9.7 62.8 52.7 13.4 29.9 78.8 126.1 31.5 30.7 39.9 60.9 47.7 34.6 27.5 41.4 18.8 32.2 107.3 25.7 76.5 10.2 166.2 136.6 25.8 50.3 3.3 6.0 74.1 29.5 18.4 32.8 193.5 234.7 10.6 66.3 52.2 13.2 61.7 14.2 44.1 56.2 2.0 4.3 4.0 28.5 118.7 515.8 111.9 5.3 0.7 5.2 8.7 4.8 0.4 1.7 3.3 20.6 0.1 0.6 2.6 71.8 4.7 3.8 93.7 0.3 6.4 25.2 41.2 43.5 28.9 24.3 28.7 42.3 41.3 39.5 31.9 37.6 57.2 10.3 9.6 0.6 17.0 1.9 10.6 6.6 23.0 0.6 4.0 12.8 6.7 25.9 5.7 23.1 31.3 10.4 115.9 37.5 149.2 49.0 6.1 1.5 3.2 9.8 15.0 5.3 3.4 16.3 6.6 72.3 43.2 2.0 10.2 41.9 270.0 31.8 11.9 17.8 5.0 17.5 115.7 16.2 5.9 14.9 7.2 76.1 11.2 78.2 3.7 9.5 5.4 18.6 5.0 83.3 5.3 214.3 93.6 6.7 16.5 0.0 3.9 5.5 10.0 13.1 4.3 43.1 1.5 17.4 0.7 6.7 962.5 8.4 36.8 23.2 41.1 ST3GAL5 "SIAT9, SIATGM3S, ST3GalV" ENSG00000115525 "ST3 beta-galactoside alpha-2,3-sialyltransferase 5" Q9UNP4 2 85837120-85905199 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adrenal gland: 47.4" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 112.8;Oligodendrocyte precursor cells: 94.0;Oligodendrocytes: 108.4" "Cancer enhanced" "Detected in all" "thyroid cancer: 41.7" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "AN3-CA: 54.4;RT4: 47.0;SK-MEL-30: 40.8;U-266/84: 42.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034708, HPA040425, HPA068928" Uncertain Approved Vesicles NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 2: Karpas-707 - Immune response" "Cluster 65: Plasmacytoid DCs - Unknown function" Vesicles "HPA034708: AB_10601594, HPA040425: AB_2676978, HPA068928: AB_2686060" "unprognostic (7.90e-2)" "unprognostic (1.61e-2)" "unprognostic (3.84e-2)" "unprognostic (2.93e-2)" "unprognostic (1.27e-1)" "unprognostic (1.75e-1)" "unprognostic (1.12e-2)" "unprognostic (5.81e-3)" "unprognostic (1.38e-1)" "unprognostic (6.45e-2)" "unprognostic (5.03e-3)" "unprognostic (3.43e-2)" "prognostic unfavorable (2.25e-7)" "unprognostic (2.22e-1)" "unprognostic (5.74e-2)" "prognostic favorable (4.99e-4)" "prognostic favorable (4.48e-4)" 17.5 47.4 17.1 4.6 26.9 2.3 8.5 16.4 20.1 5.4 7.9 5.0 1.0 9.9 0.9 2.7 10.4 8.1 4.2 16.0 24.7 2.8 9.8 14.6 9.1 24.7 22.6 10.1 3.9 0.4 12.8 17.7 23.1 6.7 2.6 31.0 7.1 0.5 12.4 6.1 6.9 3.5 20.6 20.0 5.6 10.8 23.6 5.0 27.9 3.5 4.4 20.8 5.9 41.6 0.3 27.0 2.5 54.4 22.0 11.8 8.0 5.9 18.0 5.6 5.0 0.5 19.6 0.7 0.2 10.2 2.5 1.0 3.6 6.4 7.0 0.2 3.2 0.6 1.1 1.0 17.6 0.4 7.8 6.9 0.8 2.1 0.8 10.1 13.7 7.4 0.8 30.2 18.3 1.8 1.9 3.1 0.2 9.6 0.0 3.5 17.0 11.0 2.9 47.0 3.8 3.8 0.2 0.1 40.8 5.4 0.2 1.1 4.5 0.1 2.7 0.1 0.4 30.0 42.5 0.5 4.2 5.6 27.7 0.6 0.8 0.1 0.6 3.0 0.8 1.1 0.3 0.4 0.5 0.7 0.3 0.3 0.6 0.6 2.4 0.2 0.1 0.3 17.1 26.9 16.4 20.1 16.0 24.7 24.7 22.6 23.1 20.6 23.6 41.6 8.5 86.6 112.8 37.5 29.1 5.6 27.6 20.5 1.2 56.6 3.1 2.3 1.9 40.0 33.9 3.7 58.4 0.4 48.3 0.2 3.9 12.0 12.3 9.0 27.8 8.1 6.7 0.4 46.9 16.6 1.1 21.7 6.1 8.5 34.8 35.2 29.6 21.1 35.6 72.3 60.2 0.1 12.2 45.4 18.1 12.0 8.1 24.9 32.0 45.9 20.1 56.0 12.3 94.0 108.4 6.2 0.1 1.9 19.5 6.8 0.0 3.7 10.7 45.2 0.0 21.3 5.0 8.4 16.1 0.2 3.8 0.3 28.9 6.3 0.1 8.3 ST6GAL1 SIAT1 ENSG00000073849 "ST6 beta-galactoside alpha-2,6-sialyltransferase 1" P15907 3 186930325-187078553 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted secreted proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 5 "liver: 495.9;lymphoid tissue: 148.1" "Cell type enhanced" "Detected in many" "Collecting duct cells: 237.3;Hepatic stellate cells: 258.5;Hepatocytes: 608.7;Microglial cells: 602.4" "Cancer enhanced" "Detected in all" "liver cancer: 70.0" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "Daudi: 250.6;U-266/70: 628.0;U-266/84: 887.9;U-698: 334.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB015018, CAB016122" Supported "Secreted to blood" NA NA 15000000 3300000 "Cluster 21: B-cells - Adaptive immune response" "Cluster 85: Liver - Metabolism" "Cluster 29: U-266 - Adaptive immune response" "Cluster 15: Hepatocytes - Hemostasis" "CAB015018: AB_629203, CAB016122: AB_627178" "unprognostic (5.85e-3)" "unprognostic (4.19e-2)" "unprognostic (1.30e-1)" "unprognostic (1.62e-1)" "unprognostic (2.64e-1)" "unprognostic (2.44e-2)" "unprognostic (1.38e-3)" "unprognostic (3.43e-2)" "unprognostic (3.17e-1)" "unprognostic (2.20e-1)" "unprognostic (3.99e-1)" "unprognostic (1.43e-1)" "unprognostic (1.91e-2)" "unprognostic (7.30e-3)" "unprognostic (1.25e-1)" "unprognostic (1.16e-1)" "unprognostic (1.93e-2)" 24.5 12.5 27.0 50.2 26.2 15.2 32.5 29.8 24.8 61.4 33.3 38.1 13.9 16.1 5.9 13.5 27.0 17.8 36.0 25.8 33.9 60.0 495.9 30.1 101.7 44.0 37.5 10.1 8.1 45.5 9.8 18.5 50.3 48.8 45.4 2.6 39.3 14.6 12.8 8.3 29.1 18.9 44.1 67.5 28.8 3.5 39.2 66.6 64.8 20.2 148.1 28.0 8.9 48.3 4.3 5.0 20.6 17.1 1.1 0.0 36.3 1.6 3.0 1.4 2.0 1.9 2.0 250.6 19.5 0.1 8.8 10.1 132.7 15.4 1.6 11.3 7.4 10.1 0.8 119.0 1.3 22.8 75.0 1.7 28.3 0.0 11.5 19.9 77.5 24.2 52.2 20.3 5.2 8.7 17.0 14.7 49.9 11.3 7.6 38.2 0.4 8.1 9.9 0.5 36.4 4.1 1.5 26.6 64.6 29.1 38.9 16.8 32.6 0.2 3.3 0.6 2.1 628.0 887.9 334.0 0.5 45.4 84.7 22.6 8.9 3.6 46.9 16.2 42.9 87.9 51.3 39.7 14.2 83.3 80.4 58.4 4.2 26.9 29.3 11.9 43.8 58.7 27.0 26.2 29.8 24.8 25.8 33.9 44.0 37.5 50.3 44.1 39.2 48.3 34.6 44.8 27.4 13.4 110.0 4.0 13.8 68.0 4.6 0.3 5.1 4.1 26.2 75.8 55.9 237.3 0.0 0.3 26.3 20.7 0.0 17.1 0.5 8.9 5.0 56.0 94.1 24.8 47.2 0.9 3.5 3.7 7.7 16.1 10.8 7.3 258.5 608.7 20.3 0.0 31.5 10.9 34.6 61.3 16.4 1.1 0.3 18.2 7.2 602.4 17.2 0.1 26.8 145.3 2.8 6.0 17.8 0.7 124.3 103.6 0.6 0.5 39.8 1.1 0.0 2.2 6.8 0.0 0.5 0.8 1.6 0.7 28.4 0.3 37.3 39.0 ST6GAL2 "KIAA1877, SIAT2, St6GalII" ENSG00000144057 "ST6 beta-galactoside alpha-2,6-sialyltransferase 2" Q96JF0 2 106801600-106887108 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 11.0;thyroid gland: 28.7" "Group enriched" "Detected in some" 4 "Astrocytes: 58.8;Excitatory neurons: 78.7;Granulosa cells: 111.5;Inhibitory neurons: 44.8;Oligodendrocyte precursor cells: 94.0" "Cancer enriched" "Detected in many" 7 "thyroid cancer: 16.0" "Group enriched" "Detected in many" 77 "amygdala: 6.9;basal ganglia: 7.4;cerebral cortex: 11.0;hippocampal formation: 10.8;thalamus: 4.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "A549: 5.3;hTERT-RPE1: 6.4;NTERA-2: 4.4;PC-3: 5.9;RPMI-8226: 9.6;SCLC-21H: 6.1;U-138 MG: 7.5;U-266/70: 9.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA014459 Uncertain Approved "Nucleoplasm,Nucleoli fibrillar center" NA NA "Cluster 68: Epididymis - Unknown function" "Cluster 25: RPMI-8226 - Immune response" "Cluster 40: Granulosa cells - Unknown function" "Nucleoli fibrillar center" Nucleoplasm "HPA014459: AB_1857528" "unprognostic (2.08e-1)" "unprognostic (5.80e-2)" "unprognostic (1.55e-1)" "unprognostic (4.63e-2)" "unprognostic (6.44e-3)" "unprognostic (1.62e-1)" "unprognostic (2.35e-2)" "unprognostic (1.10e-2)" "unprognostic (1.29e-4)" "unprognostic (4.56e-3)" "unprognostic (7.04e-2)" "unprognostic (1.84e-2)" "unprognostic (7.01e-4)" "unprognostic (4.70e-4)" "unprognostic (4.06e-2)" "unprognostic (2.83e-1)" "unprognostic (2.07e-2)" 0.5 0.1 6.9 0.2 7.4 1.0 0.7 0.0 11.0 1.7 0.0 1.1 0.2 2.6 0.3 1.8 0.7 5.1 0.5 10.8 0.0 0.4 2.6 0.6 0.3 0.0 0.0 0.6 0.1 0.1 0.1 1.5 0.0 0.8 2.3 1.9 0.8 0.8 0.1 0.7 0.4 2.0 0.0 0.1 0.6 5.3 4.6 0.1 28.7 0.0 0.3 0.6 1.0 0.1 0.0 5.3 2.8 0.0 0.0 0.0 0.1 0.2 0.0 1.2 0.3 0.1 0.0 0.6 0.1 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.1 0.0 0.0 0.9 0.0 6.4 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 4.4 0.0 5.9 0.0 0.0 9.6 0.2 0.0 6.1 3.9 0.0 0.0 0.0 0.2 0.0 0.1 0.0 7.5 0.1 0.2 0.0 9.9 0.2 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 6.9 7.4 0.0 11.0 10.8 0.0 0.0 0.0 0.0 0.0 4.6 0.1 0.0 0.0 0.0 58.8 0.0 0.9 0.2 0.0 18.8 6.6 0.2 3.4 1.4 0.0 0.6 1.8 0.0 0.0 0.0 4.7 0.0 0.1 0.4 0.8 12.2 0.3 1.2 6.3 78.7 0.0 0.0 1.7 0.0 0.5 0.0 111.5 2.2 0.0 0.2 0.0 44.8 3.3 0.0 0.0 0.0 1.2 0.3 0.1 0.0 2.8 0.0 0.9 0.0 94.0 1.9 0.0 1.0 0.7 0.0 0.3 0.0 0.6 0.0 0.5 0.0 0.2 2.9 0.1 1.1 4.3 0.0 0.3 0.1 0.1 3.2 0.0 ST6GALNAC1 "SIAT7A, ST6GalNAcI" ENSG00000070526 "ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 1" Q9NSC7 17 76624761-76643786 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "cervix: 61.1;intestine: 195.9;stomach 1: 64.9" "Cell type enriched" "Detected in many" 5 "Intestinal goblet cells: 801.0" "Cancer enhanced" "Detected in many" "colorectal cancer: 41.2" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 5 "memory CD4 T-cell: 8.9;naive CD4 T-cell: 3.4" "Lineage enriched" "Detected in single" 32 "T-cells: 8.9" "Group enriched" "Detected in some" 4 "K-562: 65.5;OE19: 107.5" "Not detected" "Not detected" "Low region specificity" "Detected in some" "HPA014767, HPA014975" Enhanced Approved "Nucleoplasm,Golgi apparatus" NA NA 3500000 "Cluster 20: T-cells - T-cell receptor" "Cluster 37: Intestine - Unknown function" "Cluster 21: OE19 - Mitochondria" "Cluster 27: Mucus-secreting cells - Mucin production" "Golgi apparatus" Nucleoplasm "HPA014767: , HPA014975: AB_1857529" "unprognostic (4.59e-2)" "unprognostic (8.60e-3)" "unprognostic (5.32e-3)" "unprognostic (1.86e-3)" "unprognostic (6.31e-3)" "prognostic favorable (2.54e-5)" "unprognostic (1.39e-2)" "unprognostic (1.63e-2)" "unprognostic (2.45e-1)" "unprognostic (2.58e-2)" "unprognostic (8.64e-3)" "unprognostic (2.81e-1)" "unprognostic (1.67e-1)" "unprognostic (2.75e-1)" "unprognostic (1.18e-1)" "unprognostic (5.87e-3)" "unprognostic (5.58e-2)" 1.9 0.1 6.0 12.6 5.6 2.8 2.0 5.7 9.2 61.1 4.5 155.3 62.5 5.1 3.9 24.4 3.8 18.3 3.4 5.5 6.0 0.4 0.1 5.7 1.2 6.1 6.0 0.8 0.7 0.1 0.0 2.1 6.4 6.9 195.9 1.0 26.3 0.5 1.4 0.9 75.8 5.4 5.8 14.6 64.9 3.1 6.1 0.2 0.3 0.9 2.3 3.1 4.5 5.6 0.2 2.4 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 3.4 0.2 11.9 0.0 0.0 12.4 0.0 2.9 0.0 0.0 0.0 19.5 0.9 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.3 65.5 0.0 0.0 0.0 0.2 0.2 0.0 107.5 0.4 0.0 0.0 0.4 0.1 0.7 0.0 0.7 0.0 0.1 0.0 0.1 0.0 0.3 0.6 0.0 0.2 0.1 0.0 0.1 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 8.9 0.1 0.0 0.0 3.4 0.0 0.2 0.0 0.0 0.0 1.3 0.9 6.0 5.6 5.7 9.2 5.5 6.0 6.1 6.0 6.4 5.8 6.1 5.6 8.6 16.0 7.5 0.7 0.3 0.1 5.7 90.2 12.0 0.1 0.1 0.0 2.0 17.2 143.4 0.0 0.0 0.3 0.0 133.3 0.0 1.4 0.3 85.1 7.6 27.2 33.0 6.7 0.4 18.2 0.1 1.3 65.7 77.6 0.0 0.3 8.6 0.0 0.3 0.0 0.3 801.0 50.8 0.0 0.0 0.9 1.5 1.1 0.0 18.7 0.0 0.0 0.0 1.5 0.3 42.8 76.1 0.0 0.0 2.4 51.6 0.0 117.4 1.2 0.0 0.3 5.3 0.4 0.1 12.8 0.1 0.1 1.8 63.3 123.1 24.5 ST6GALNAC2 "SIAT7, SIAT7B, SIATL1, ST6GalNAII, STHM" ENSG00000070731 "ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 2" Q9UJ37 17 76565377-76586956 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 10 "Early spermatids: 501.1;Late spermatids: 1763.3" "Cancer enhanced" "Detected in all" "melanoma: 22.0" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in some" 9 "neutrophil: 47.0" "Lineage enriched" "Detected in many" 16 "granulocytes: 47.0" "Cell line enhanced" "Detected in some" "BEWO: 25.4;HaCaT: 33.8;HBEC3-KT: 28.5;hTCEpi: 73.1;MCF7: 36.4;SK-MEL-30: 112.5;T-47d: 23.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "Intracellular and membrane" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 77: Retina - Visual perception" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 31: Spermatids - Spermatogenesis" "unprognostic (8.93e-3)" "unprognostic (5.86e-3)" "unprognostic (1.67e-2)" "unprognostic (5.18e-3)" "unprognostic (3.37e-2)" "unprognostic (3.79e-2)" "unprognostic (8.79e-2)" "unprognostic (1.95e-1)" "unprognostic (5.37e-2)" "unprognostic (5.69e-2)" "prognostic unfavorable (6.48e-4)" "unprognostic (1.57e-1)" "unprognostic (5.17e-3)" "unprognostic (3.85e-2)" "unprognostic (2.84e-2)" "unprognostic (1.66e-1)" "unprognostic (1.33e-1)" 5.6 2.9 1.0 1.9 1.1 1.0 12.2 1.2 1.4 14.9 33.0 13.8 1.0 4.8 10.3 16.4 50.5 1.9 4.5 2.0 1.6 9.6 1.2 17.5 0.6 5.4 6.7 1.2 6.3 7.5 2.1 6.0 4.1 11.1 6.0 52.8 11.3 10.2 18.3 51.6 4.8 2.3 4.2 3.7 7.1 33.9 2.6 1.5 25.2 18.5 4.8 9.5 14.5 2.7 2.6 0.0 0.0 0.0 0.5 0.0 25.4 0.0 0.6 0.0 0.0 0.0 2.1 0.0 0.5 1.7 0.1 33.8 0.3 28.5 0.0 0.0 0.0 0.0 1.2 0.0 1.2 0.0 0.0 0.0 73.1 0.1 9.0 3.8 0.1 0.0 0.0 0.0 0.4 36.4 0.0 0.0 0.0 0.9 1.0 0.0 0.0 0.0 0.0 9.8 0.5 0.0 4.1 0.1 112.5 1.3 23.4 0.7 0.3 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 11.9 0.0 2.9 5.2 0.0 1.8 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 47.0 0.2 0.4 0.0 0.0 0.4 1.0 1.1 1.2 1.4 2.0 1.6 5.4 6.7 4.1 4.2 2.6 2.7 0.2 0.0 1.5 2.6 0.8 32.9 44.0 104.2 23.9 7.9 0.4 1.5 5.1 7.2 21.0 0.0 27.1 12.5 0.0 2.4 0.0 0.3 501.1 4.5 1.1 3.9 0.0 0.0 0.5 0.0 21.1 2.0 4.6 0.6 1.3 0.0 7.9 1.5 3.0 0.0 1.3 4.8 8.2 5.0 6.9 1763.3 7.5 3.8 65.8 1.0 2.7 84.9 0.0 0.0 0.2 0.1 0.5 7.2 0.2 15.2 0.7 0.5 39.3 79.7 19.7 7.3 3.4 7.6 4.6 28.8 30.3 10.5 2.2 0.0 1.6 37.6 ST6GALNAC3 SIAT7C ENSG00000184005 "ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3" Q8NDV1 1 76074746-76634603 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 21.0" "Group enriched" "Detected in many" 4 "Microglial cells: 912.5;Oligodendrocytes: 698.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in some" "AF22: 35.8;HUVEC TERT2: 45.9;SK-MEL-30: 62.3;TIME: 20.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA054566, HPA055399" Uncertain Enhanced Nucleoplasm NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 21: Non-specific - Transcription" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "HPA054566: AB_2682526, HPA055399: AB_2682806" "unprognostic (7.85e-2)" "unprognostic (1.78e-1)" "unprognostic (2.99e-2)" "unprognostic (2.70e-4)" "unprognostic (2.76e-2)" "unprognostic (2.21e-2)" "unprognostic (6.55e-3)" "unprognostic (7.31e-2)" "unprognostic (2.14e-1)" "unprognostic (4.57e-1)" "unprognostic (1.50e-1)" "unprognostic (5.95e-2)" "unprognostic (9.97e-4)" "unprognostic (3.33e-4)" "unprognostic (5.44e-2)" "unprognostic (1.92e-1)" "unprognostic (3.44e-4)" 8.8 1.4 5.8 1.8 13.3 3.1 6.4 14.3 8.4 1.9 10.4 2.0 0.7 5.9 0.5 1.9 2.7 2.5 4.4 6.9 9.0 8.7 2.0 5.2 2.0 15.2 10.6 2.3 0.9 4.4 2.1 3.1 17.2 1.1 2.4 3.9 1.1 1.6 1.6 0.8 1.4 4.5 13.3 1.4 1.5 0.3 11.3 0.9 13.3 6.5 0.7 2.6 1.6 21.0 0.2 0.0 35.8 0.0 0.6 0.0 0.0 0.0 4.2 0.6 0.4 11.9 0.1 0.6 2.4 0.3 2.3 0.1 0.0 0.4 0.3 0.0 2.5 0.0 0.0 0.0 0.4 0.0 0.0 0.4 0.6 0.0 0.0 1.1 45.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.4 2.9 0.0 1.8 1.7 0.0 0.0 0.0 2.7 8.8 0.0 0.0 62.3 8.3 0.0 0.2 20.6 0.3 2.8 0.1 3.3 0.0 0.0 0.0 0.0 8.4 5.5 0.0 6.3 2.8 0.0 2.2 0.0 2.6 0.3 0.5 2.3 3.8 1.3 1.4 3.9 0.3 4.3 0.0 0.0 1.9 5.8 13.3 14.3 8.4 6.9 9.0 15.2 10.6 17.2 13.3 11.3 21.0 59.8 3.2 1.5 174.3 5.6 0.3 0.2 0.0 0.6 3.2 0.6 1.0 1.2 0.0 0.0 3.7 0.0 0.1 0.2 0.5 0.0 0.0 0.0 0.1 4.5 23.2 0.0 0.4 107.0 0.0 0.1 2.5 3.6 0.1 0.0 0.8 66.0 0.8 1.1 0.0 101.4 0.5 0.0 9.8 0.7 0.8 0.0 3.7 5.4 912.5 3.0 12.3 1.0 23.1 698.3 0.2 3.4 0.0 0.2 0.1 0.0 0.0 0.0 0.5 0.0 1.1 1.3 0.2 0.7 0.1 0.4 0.1 2.0 6.9 0.3 0.1 ST6GALNAC4 "SIAT3C, SIAT7D, ST6GALNACIV" ENSG00000136840 "ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4" Q9H4F1 9 127907886-127917041 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "pancreas: 72.0" "Cell type enhanced" "Detected in many" "Enteroendocrine cells: 67.8;Erythroid cells: 112.2;Plasma cells: 93.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 9 "plasmacytoid DC: 233.9" "Lineage enriched" "Detected in all" 9 "dendritic cells: 233.9" "Cell line enhanced" "Detected in many" "HDLM-2: 105.3;RPMI-8226: 149.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA009042 Approved "Nucleoplasm,Golgi apparatus" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 50: Non-specific - Ribosome" "Cluster 25: RPMI-8226 - Immune response" "Cluster 6: Erythroid cells - Oxygen transport" "Golgi apparatus" Nucleoplasm "HPA009042: AB_1079963" "unprognostic (2.05e-3)" "unprognostic (2.32e-1)" "unprognostic (2.22e-1)" "unprognostic (1.53e-2)" "unprognostic (3.18e-1)" "unprognostic (2.32e-1)" "prognostic unfavorable (8.63e-7)" "unprognostic (1.62e-2)" "unprognostic (4.26e-1)" "prognostic unfavorable (5.12e-4)" "unprognostic (1.04e-1)" "unprognostic (3.04e-1)" "prognostic unfavorable (8.39e-4)" "unprognostic (1.30e-3)" "unprognostic (2.72e-1)" "unprognostic (2.64e-2)" "unprognostic (2.03e-2)" 20.9 16.9 11.2 10.6 10.4 40.0 16.6 11.9 15.2 18.1 12.7 18.6 14.9 18.5 6.3 15.2 19.3 8.6 34.2 11.5 9.9 20.5 9.0 27.7 14.0 10.6 9.8 25.1 72.0 7.4 20.8 5.3 9.6 13.6 6.6 1.0 11.8 15.3 24.4 9.7 19.4 7.5 10.4 37.2 15.1 5.4 10.2 5.9 11.3 10.2 9.4 17.9 14.7 9.7 9.5 15.9 4.1 20.1 27.4 20.8 3.0 16.3 17.6 16.2 9.4 9.1 17.0 60.2 24.0 20.2 22.8 23.0 8.2 17.2 2.7 105.3 7.2 19.3 48.8 34.2 33.3 1.6 19.1 25.6 18.0 14.4 12.9 13.1 43.2 11.4 14.0 38.9 7.8 4.4 3.8 2.2 4.6 30.7 38.9 18.3 10.5 149.6 16.5 0.5 33.8 7.8 23.6 49.8 3.0 1.3 10.3 12.2 31.3 13.1 15.2 41.3 25.8 63.5 35.0 18.8 26.2 8.4 1.9 3.7 9.0 0.3 11.1 8.0 12.3 25.1 6.9 13.3 11.3 18.6 8.6 11.9 1.1 18.9 14.5 233.9 13.3 10.2 11.2 10.4 11.9 15.2 11.5 9.9 10.6 9.8 9.6 10.4 10.2 9.7 15.0 9.6 26.5 2.3 35.5 2.2 12.2 21.1 8.6 3.1 5.2 4.8 12.2 10.0 9.9 1.8 0.0 1.1 48.1 27.0 1.9 16.1 0.2 2.5 13.8 14.8 67.8 112.2 3.7 14.1 15.6 10.7 6.6 2.6 8.2 7.1 12.1 1.9 23.0 0.0 4.9 16.6 8.2 13.3 10.0 0.6 17.4 9.2 7.2 1.9 11.2 15.0 11.3 2.0 1.0 9.3 9.1 42.9 93.9 12.8 17.1 20.6 5.1 1.9 13.1 9.2 10.9 0.3 1.5 9.3 3.1 4.5 10.2 34.0 13.0 10.6 ST8SIA1 "SIAT8, SIAT8A" ENSG00000111728 "ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1" Q92185 12 22063773-22437041 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Lipid metabolism, Sphingolipid metabolism" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 15.0" "Cell type enhanced" "Detected in many" "Excitatory neurons: 133.2;Inhibitory neurons: 152.0;Oligodendrocyte precursor cells: 198.0" "Cancer enhanced" "Detected in some" "glioma: 2.0" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 6.5;ASC TERT1: 4.2;hTERT-RPE1: 3.0;RPTEC TERT1: 3.3;SK-MEL-30: 6.2;WM-115: 6.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA026775 Approved NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 70: Brain - Nervous system development" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "HPA026775: AB_1857534" "unprognostic (1.98e-1)" "unprognostic (5.76e-3)" "unprognostic (1.79e-1)" "unprognostic (9.58e-2)" "unprognostic (2.89e-1)" "unprognostic (6.44e-3)" "unprognostic (1.76e-2)" "unprognostic (1.07e-2)" "unprognostic (3.07e-1)" "unprognostic (1.99e-1)" "unprognostic (6.37e-3)" "unprognostic (2.80e-2)" "unprognostic (1.07e-8)" "unprognostic (1.10e-1)" "unprognostic (1.95e-1)" "unprognostic (5.28e-2)" "unprognostic (3.16e-2)" 1.0 3.5 7.3 2.5 7.0 1.2 2.9 15.0 6.6 2.6 0.0 3.7 0.1 2.3 0.6 1.3 1.3 1.0 2.3 6.3 9.8 0.7 0.2 2.0 4.6 11.6 9.2 1.2 0.5 6.4 0.2 0.1 9.3 3.1 1.6 6.0 1.4 2.0 0.4 2.1 1.3 2.2 8.6 1.3 1.1 0.4 6.8 0.9 0.7 0.4 4.8 4.1 1.8 6.4 0.0 0.3 6.5 0.0 1.0 4.2 0.6 0.0 0.0 0.1 0.3 0.2 0.1 0.8 0.0 0.0 0.1 0.3 0.0 0.1 0.4 0.0 0.0 0.8 0.1 0.0 0.0 0.2 0.0 0.4 0.7 0.1 0.6 3.0 0.1 0.0 0.0 0.4 0.2 0.0 0.9 0.2 1.6 2.6 0.0 0.0 0.1 0.1 3.3 0.0 0.0 0.1 0.0 0.1 6.2 0.2 0.5 0.0 0.0 0.5 0.6 0.0 1.0 0.5 0.4 0.5 1.0 0.0 6.5 0.3 0.0 0.0 0.1 0.0 0.2 0.0 0.7 0.6 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.8 0.1 7.3 7.0 15.0 6.6 6.3 9.8 11.6 9.2 9.3 8.6 6.8 6.4 0.6 0.0 1.8 43.1 0.4 4.5 0.4 1.4 0.0 9.6 7.2 5.8 4.1 0.0 1.6 0.0 45.9 3.6 1.7 0.1 1.9 0.0 12.8 8.7 2.9 1.3 0.0 3.2 133.2 0.0 13.8 8.3 0.0 0.3 34.1 2.6 1.8 0.0 0.9 5.0 152.0 0.0 0.0 0.0 2.7 5.0 0.3 0.5 12.4 17.8 0.2 46.2 0.0 198.0 4.7 0.0 0.0 0.0 0.7 3.5 0.0 0.5 9.4 4.2 0.0 43.9 2.3 6.3 6.3 0.0 2.4 3.7 5.9 31.3 0.0 0.2 STK10 "LOK, PRO2729" ENSG00000072786 "Serine/threonine kinase 10" O94804 5 172042079-172188224 "Disease related genes, Enzymes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 76.5;lymphoid tissue: 45.2" "Cell type enhanced" "Detected in all" "dendritic cells: 107.7;Kupffer cells: 91.4;NK-cells: 171.0;T-cells: 81.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "WM-115: 143.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015083, CAB020840" Enhanced Approved "Nucleoplasm,Plasma membrane" NA NA 16000 "Cluster 51: Monocytes - Innate immune response" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 17: WM-115 - Nervous system development" "Cluster 63: NK-cells & T-cells - Immune response" "Nucleoplasm, Plasma membrane" "CAB020840: , HPA015083: AB_2669151" "unprognostic (1.17e-1)" "unprognostic (5.43e-2)" "prognostic favorable (2.76e-4)" "unprognostic (2.88e-1)" "unprognostic (6.96e-3)" "unprognostic (1.02e-1)" "unprognostic (5.25e-3)" "unprognostic (3.07e-2)" "unprognostic (1.07e-1)" "unprognostic (1.03e-1)" "unprognostic (2.65e-1)" "unprognostic (3.43e-1)" "prognostic unfavorable (1.63e-4)" "unprognostic (1.09e-1)" "unprognostic (1.01e-2)" "unprognostic (3.10e-1)" "unprognostic (1.84e-1)" 14.9 5.7 3.1 37.1 3.6 76.5 11.4 18.4 5.6 4.5 3.5 8.5 8.4 4.9 1.7 5.6 4.7 13.2 7.6 3.1 4.0 5.9 6.2 18.4 44.1 6.2 4.4 2.5 7.2 3.1 4.1 17.2 5.8 4.4 6.9 1.2 4.7 3.5 5.0 14.2 16.0 7.8 5.4 45.2 11.1 14.0 6.4 20.6 5.3 5.5 25.0 14.9 5.2 7.0 22.2 20.2 12.7 18.8 14.7 18.1 31.5 28.4 24.0 20.2 18.9 10.6 28.6 26.8 14.6 35.6 42.3 25.4 5.7 35.1 13.5 35.0 9.3 32.1 8.2 6.1 20.2 32.7 36.4 17.4 7.5 27.4 23.1 7.5 18.3 10.4 3.0 36.2 14.7 35.7 23.5 73.4 5.0 11.3 16.1 38.2 9.9 17.7 8.2 27.6 8.3 10.2 16.4 22.5 77.9 15.6 8.2 68.7 24.8 22.3 11.3 15.8 15.5 30.2 48.4 17.1 29.4 49.8 143.3 16.7 26.5 23.4 36.5 46.3 26.9 10.0 19.3 26.3 22.5 8.1 11.0 20.0 48.9 16.9 71.8 7.1 26.7 44.0 3.1 3.6 18.4 5.6 3.1 4.0 6.2 4.4 5.8 5.4 6.4 7.0 35.8 3.2 11.2 1.6 40.5 6.6 8.4 7.2 5.7 4.3 3.3 3.7 3.8 5.7 6.1 1.8 6.2 4.1 107.7 11.8 1.9 4.5 2.5 3.5 4.6 23.9 12.0 11.8 8.5 6.2 27.2 9.3 20.9 7.1 28.4 3.6 18.2 2.3 36.3 47.1 7.9 19.9 2.0 91.4 43.8 3.2 2.8 61.3 8.8 32.8 49.8 2.1 171.0 10.1 14.4 10.7 11.8 1.5 42.8 11.7 6.5 2.0 6.1 2.2 13.1 5.1 10.2 5.3 7.8 2.6 4.1 5.1 81.4 11.4 5.3 10.7 STK11 "LKB1, PJS" ENSG00000118046 "Serine/threonine kinase 11" Q15831 19 1177558-1228431 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Autophagy, Cell cycle, Differentiation, DNA damage, Spermatogenesis" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 154.9;Late spermatids: 338.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "neutrophil: 9.9" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB016231, HPA017254, CAB022105, HPA067481" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 59: Non-specific - Translation" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 31: Spermatids - Spermatogenesis" Nucleoplasm Cytosol "CAB016231: AB_627890, CAB022105: , HPA017254: AB_1852924, HPA067481: AB_2685847" "unprognostic (8.60e-2)" "unprognostic (1.68e-1)" "unprognostic (5.00e-2)" "prognostic favorable (3.69e-5)" "unprognostic (2.04e-2)" "prognostic favorable (1.96e-4)" "unprognostic (9.11e-3)" "unprognostic (3.19e-1)" "unprognostic (9.08e-2)" "unprognostic (1.26e-1)" "unprognostic (1.95e-3)" "unprognostic (7.70e-3)" "unprognostic (3.54e-2)" "unprognostic (3.16e-2)" "unprognostic (1.60e-1)" "unprognostic (3.31e-1)" "unprognostic (3.12e-3)" 32.1 44.2 18.8 18.2 15.5 34.1 32.3 24.8 23.5 35.4 24.7 38.7 25.6 33.6 5.5 39.7 34.9 11.8 48.4 18.3 14.7 36.4 45.5 30.5 20.5 19.2 19.4 37.9 34.2 16.1 36.8 12.6 15.2 39.3 7.7 5.7 29.7 16.1 108.2 40.2 37.7 9.6 16.3 48.3 38.1 102.4 17.6 15.0 34.3 27.7 12.9 34.4 35.0 14.9 50.0 25.8 19.9 35.9 18.6 17.0 35.5 24.0 27.7 25.1 25.4 22.5 37.1 31.9 24.8 27.8 11.2 32.3 20.1 41.9 8.2 60.2 37.8 34.8 1.7 26.4 38.1 36.6 53.5 30.5 28.9 19.4 29.2 22.3 25.2 28.1 63.1 51.1 13.9 39.3 31.9 27.7 33.0 19.6 25.1 50.0 20.0 36.1 21.1 39.7 39.8 26.6 0.0 19.7 24.2 11.4 30.3 55.2 33.7 24.6 25.0 45.2 38.7 85.3 38.1 25.7 22.6 48.1 25.5 1.7 3.3 3.9 0.4 5.5 0.3 2.3 0.8 1.4 1.6 0.7 0.7 0.6 9.9 1.4 5.7 0.8 0.6 0.5 18.8 15.5 24.8 23.5 18.3 14.7 19.2 19.4 15.2 16.3 17.6 14.9 24.5 6.4 13.7 12.7 10.5 16.7 7.4 9.5 9.6 25.5 22.0 18.4 13.7 15.7 9.0 23.9 18.8 7.5 20.1 44.4 7.9 9.4 154.9 18.0 18.1 15.7 15.0 27.3 7.9 14.0 5.3 13.2 21.9 17.8 2.5 80.3 15.4 31.6 15.2 18.5 8.5 33.1 6.1 18.3 26.4 338.7 24.5 20.7 16.0 11.2 20.4 21.2 9.2 9.0 6.5 16.7 29.3 20.7 10.2 15.1 27.5 11.0 9.3 21.0 13.1 21.5 23.7 85.5 20.1 14.6 15.5 8.8 16.6 45.2 35.4 12.6 STK16 "MPSK, PKL12" ENSG00000115661 "Serine/threonine kinase 16" O75716 2 219245455-219250337 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA029450 Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 18: Non-specific - Mitochondria" "Cluster 30: Epithelial cell lines - Translation" "Cluster 34: Spermatids - Unknown function" Cytosol "Nucleoplasm, Plasma membrane" "HPA029450: AB_10603118" "unprognostic (1.99e-1)" "unprognostic (2.08e-1)" "unprognostic (5.84e-2)" "prognostic favorable (6.09e-4)" "unprognostic (6.21e-2)" "unprognostic (5.55e-2)" "unprognostic (4.98e-3)" "unprognostic (4.25e-1)" "unprognostic (1.48e-1)" "unprognostic (4.22e-2)" "unprognostic (1.73e-2)" "unprognostic (3.17e-1)" "unprognostic (4.39e-3)" "unprognostic (1.76e-1)" "unprognostic (2.00e-1)" "unprognostic (2.68e-1)" "unprognostic (1.34e-1)" 15.2 24.9 17.6 11.8 17.5 15.0 16.2 16.3 20.5 14.0 19.5 20.0 17.3 13.8 20.8 22.8 18.1 13.0 19.0 16.5 16.8 26.5 43.2 14.3 17.6 17.9 17.5 14.8 30.9 22.7 19.8 9.2 16.9 20.3 13.5 7.9 20.0 10.9 14.4 17.3 17.8 9.9 17.4 21.2 24.2 27.7 18.6 20.5 19.3 8.2 14.5 17.8 14.8 16.5 14.1 18.8 15.7 13.2 40.0 40.0 17.9 17.8 23.6 14.3 14.7 21.2 31.0 8.3 24.4 32.0 23.4 14.5 18.5 30.0 7.8 20.0 19.8 17.7 15.4 19.1 34.9 17.6 20.1 40.1 48.1 20.8 57.4 29.8 17.9 18.7 23.1 21.5 26.8 27.1 19.4 38.0 14.5 25.7 10.3 18.1 17.5 24.9 32.2 16.1 12.3 14.6 5.8 25.5 39.0 11.2 27.4 36.4 13.7 20.6 14.0 16.4 17.4 25.9 12.1 19.5 22.9 18.4 18.3 1.6 7.0 5.3 4.9 3.8 5.5 7.2 6.0 9.2 6.8 6.0 6.1 7.9 4.1 14.5 3.1 5.8 7.3 8.7 17.6 17.5 16.3 20.5 16.5 16.8 17.9 17.5 16.9 17.4 18.6 16.5 11.8 6.4 5.6 3.6 22.4 9.8 18.1 32.6 24.5 7.9 31.8 31.8 9.5 24.3 19.7 7.3 16.7 24.0 23.6 27.6 68.4 40.3 87.2 21.4 13.3 14.0 25.8 36.0 2.2 58.5 25.0 15.8 17.3 12.9 8.2 17.9 12.5 43.7 28.4 13.5 2.7 38.7 16.2 27.1 17.6 70.3 15.2 17.8 21.4 0.0 38.4 22.1 44.3 4.0 6.8 33.3 44.3 13.5 27.6 18.6 58.9 80.2 19.6 19.1 0.0 11.9 19.2 43.1 9.6 28.2 11.2 12.9 22.1 33.6 34.2 20.8 STK17A DRAK1 ENSG00000164543 "Serine/threonine kinase 17a" Q9UEE5 7 43582758-43650713 "Enzymes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Basal prostatic cells: 644.6;T-cells: 273.7;Urothelial cells: 326.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018138, HPA037979" Uncertain Supported "Nuclear speckles,Plasma membrane" Yes No "Cluster 48: NK-cells - Unknown function" "Cluster 16: Immune cells - Immune response" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 22: Epithelial cell types - Mixed function" "Nuclear speckles" "Plasma membrane" "HPA018138: AB_2669784, HPA037979: AB_10795247" "unprognostic (1.81e-3)" "unprognostic (1.08e-2)" "unprognostic (2.67e-1)" "unprognostic (5.41e-2)" "unprognostic (5.11e-2)" "unprognostic (3.35e-2)" "unprognostic (1.03e-2)" "unprognostic (9.15e-3)" "unprognostic (2.07e-1)" "unprognostic (6.34e-2)" "unprognostic (1.36e-2)" "unprognostic (6.61e-2)" "unprognostic (2.99e-3)" "unprognostic (3.76e-2)" "unprognostic (3.08e-1)" "unprognostic (1.97e-3)" "unprognostic (3.66e-1)" 6.7 8.1 3.9 7.9 4.2 4.8 5.2 6.9 4.9 4.0 4.0 6.4 3.2 3.5 1.2 7.2 3.9 5.3 10.8 4.0 4.1 6.3 4.6 9.4 14.4 3.4 4.4 6.2 9.1 0.8 4.2 3.2 3.6 4.3 2.4 5.5 5.8 2.1 9.9 4.6 11.5 3.3 3.6 12.6 9.5 9.0 4.3 9.0 3.8 2.5 13.5 5.6 5.0 3.1 5.8 8.2 9.0 5.3 7.8 8.3 1.9 12.3 15.1 6.6 5.9 7.5 3.1 7.9 20.2 15.3 17.8 8.5 3.6 17.4 10.4 16.9 7.0 9.3 8.2 8.4 4.9 21.1 5.6 6.4 26.4 8.2 8.6 36.4 12.6 11.0 16.7 15.1 9.6 3.6 18.2 8.0 17.3 4.1 18.3 8.4 6.9 14.2 15.6 6.7 6.9 11.2 8.1 8.5 6.1 13.6 6.5 10.8 16.9 20.7 8.3 14.3 17.2 13.3 11.2 13.5 18.4 14.0 31.7 0.5 0.0 2.7 2.0 0.0 1.5 2.4 2.0 3.2 0.1 2.2 3.0 3.0 1.6 4.9 0.1 0.4 1.3 0.9 3.9 4.2 6.9 4.9 4.0 4.1 3.4 4.4 3.6 3.6 4.3 3.1 44.2 121.8 33.1 29.0 237.8 181.9 644.6 64.5 99.6 2.9 17.7 37.8 28.7 7.2 69.8 20.2 10.4 54.8 222.3 54.4 33.2 153.0 47.0 129.1 17.4 35.2 7.2 54.1 9.5 95.4 23.3 39.1 78.0 88.3 38.8 17.7 17.9 9.6 16.9 0.0 5.6 34.3 38.7 20.3 65.9 14.7 5.9 60.9 35.6 34.7 42.1 7.9 221.4 39.2 3.7 89.4 73.0 2.6 81.2 192.6 23.8 13.2 42.4 26.3 6.6 39.4 51.3 75.8 36.1 42.3 136.1 66.8 273.7 27.0 18.0 326.1 STK17B DRAK2 ENSG00000081320 "Serine/threonine kinase 17b" O94768 2 196133583-196176503 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "bone marrow: 376.2;lymphoid tissue: 113.3" "Cell type enhanced" "Detected in many" "B-cells: 229.3;dendritic cells: 267.7;granulocytes: 195.1;Langerhans cells: 201.3;Macrophages: 198.9;Plasma cells: 191.8;T-cells: 342.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Daudi: 122.3;HMC-1: 118.9;Karpas-707: 111.6;U-698: 132.1" "Region enriched" "Detected in all" 5 "cerebellum: 63.4" "Low region specificity" "Detected in all" HPA034858 Enhanced Uncertain "Plasma membrane,Cytosol" NA Yes "Cluster 5: Granulocytes - Unknown function" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 3: HMC-1 - Innate immune response" "Cluster 24: Non-specific - Transcription regulation" "Plasma membrane, Cytosol" "HPA034858: AB_10670981" "unprognostic (2.14e-1)" "unprognostic (2.45e-3)" "unprognostic (3.68e-2)" "unprognostic (3.61e-2)" "unprognostic (3.63e-2)" "unprognostic (7.43e-3)" "unprognostic (1.75e-1)" "unprognostic (7.63e-2)" "unprognostic (9.15e-2)" "unprognostic (1.14e-1)" "unprognostic (9.90e-2)" "unprognostic (1.52e-1)" "prognostic unfavorable (5.72e-8)" "unprognostic (1.88e-1)" "unprognostic (1.19e-2)" "unprognostic (2.64e-2)" "unprognostic (5.80e-2)" 28.2 8.9 2.1 67.0 2.9 376.2 21.5 3.7 5.3 24.2 3.3 19.1 27.8 5.4 1.8 11.9 5.8 20.4 4.6 4.1 3.3 6.5 8.5 23.6 113.3 3.1 2.0 2.2 12.7 2.1 3.0 16.7 3.2 10.5 17.5 0.4 17.0 5.7 2.4 11.2 40.1 16.8 2.2 56.9 20.1 9.5 4.0 60.9 7.2 3.5 111.1 24.4 5.2 2.9 11.0 7.5 11.2 4.2 47.7 18.1 12.4 25.7 38.4 27.7 28.5 22.8 3.9 122.3 23.1 14.8 7.3 7.4 4.7 11.1 33.4 21.8 12.7 11.6 9.1 2.2 14.2 47.0 118.9 23.1 10.9 34.3 17.7 39.2 11.5 28.5 9.1 111.6 69.4 5.9 61.6 106.0 6.3 19.9 17.2 10.1 67.5 37.4 16.3 25.6 4.2 4.2 6.6 6.4 5.4 17.2 4.3 24.3 14.0 26.8 13.1 19.3 14.7 45.5 78.9 132.1 20.2 15.9 12.1 165.1 74.3 163.1 43.7 81.3 55.4 49.2 77.0 52.8 53.0 58.6 98.6 82.4 236.7 40.8 113.1 37.7 73.8 89.3 2.1 2.9 3.7 5.3 4.1 3.3 3.1 2.0 3.2 2.2 4.0 2.9 23.3 89.8 74.0 48.3 229.3 59.9 27.1 15.1 10.8 0.9 28.9 15.2 2.6 12.8 42.5 11.0 0.0 7.9 267.7 54.0 3.9 6.6 6.8 15.3 14.1 11.3 3.0 68.8 3.4 2.8 24.0 27.2 38.2 26.5 195.1 47.4 5.3 2.4 26.1 0.0 3.1 13.9 18.3 151.1 201.3 3.6 5.6 198.9 58.7 11.2 158.0 0.6 118.4 17.6 0.7 10.9 41.6 4.5 191.8 34.3 80.7 2.5 26.9 0.3 6.6 49.7 19.7 41.1 26.3 16.4 63.4 5.1 342.5 22.6 13.2 53.8 STK19 "D6S60, G11, RP1" ENSG00000204344 "Serine/threonine kinase 19" P49842 6 31971091-31982821 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enriched" "Detected in all" 4 "Proximal tubular cells: 348.9" "Low cancer specificity" "Detected in all" "Not detected" "Not detected" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in some" "HDLM-2: 1.4;HEL: 1.5;HL-60: 1.6;REH: 1.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031511, HPA068559" Uncertain Supported "Nuclear speckles" NA NA "Cluster 30: Non-specific - Translation" "Cluster 72: Non-specific - Transcription" "Cluster 36: HEL - Hemostasis" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Nuclear speckles" "HPA031511: AB_2673915, HPA068559: AB_2686004" "unprognostic (1.65e-1)" "unprognostic (2.30e-1)" "unprognostic (3.31e-1)" "unprognostic (1.86e-1)" "unprognostic (2.63e-1)" "unprognostic (1.67e-1)" "unprognostic (1.15e-2)" "unprognostic (4.26e-2)" "prognostic unfavorable (1.18e-4)" "unprognostic (3.95e-2)" "unprognostic (2.76e-3)" "unprognostic (2.25e-2)" "unprognostic (1.08e-2)" "unprognostic (1.02e-1)" "unprognostic (1.60e-1)" "unprognostic (2.40e-1)" "unprognostic (4.10e-1)" 1.5 3.6 0.1 0.2 0.1 0.0 1.3 0.4 0.9 2.1 0.0 2.5 0.0 1.4 0.3 1.9 1.0 0.1 1.2 0.0 0.0 1.5 2.2 1.3 0.0 0.0 0.0 1.1 1.1 0.2 1.4 0.4 0.1 2.1 0.0 0.2 0.9 0.1 1.3 2.5 0.7 0.0 0.0 1.2 1.3 1.5 0.1 0.1 1.2 0.0 0.1 2.0 1.5 0.4 0.0 0.1 0.0 0.4 1.1 0.7 0.0 0.3 0.1 0.2 0.4 0.0 0.7 0.6 0.3 0.5 0.0 0.6 0.0 0.2 0.3 1.4 0.4 1.5 0.3 0.0 0.5 1.6 0.0 0.6 0.0 0.3 0.1 0.4 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.7 1.1 0.4 0.0 0.0 0.1 0.3 0.1 0.3 0.0 0.0 0.7 0.0 0.0 0.0 0.4 0.4 0.0 0.0 0.9 0.0 0.7 0.2 0.0 0.0 1.1 0.0 0.1 0.3 0.2 0.6 0.2 0.0 0.8 0.2 0.3 0.1 0.1 0.3 0.4 0.4 0.0 0.1 0.1 0.1 0.4 0.9 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.4 21.2 9.6 21.5 13.7 16.4 13.0 14.0 23.0 13.6 11.8 26.6 27.6 8.1 18.6 24.6 22.0 20.9 37.2 22.4 13.8 39.2 26.3 85.8 27.8 31.8 20.6 19.3 4.6 8.7 28.3 20.0 23.3 19.4 20.7 9.5 20.1 14.3 21.1 19.3 10.1 8.0 17.3 18.3 8.8 10.0 76.0 20.2 18.3 17.8 11.2 12.5 30.2 13.4 4.5 6.5 23.6 16.4 18.4 11.9 13.2 15.0 348.9 41.8 21.9 32.9 19.6 21.1 39.5 21.0 17.9 18.2 49.7 19.8 45.1 13.1 11.8 STK24 "MST-3, MST3, MST3B, STE20, STK3" ENSG00000102572 "Serine/threonine kinase 24" Q9Y6E0 13 98445185-98577940 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Distal enterocytes: 203.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026435, HPA026502" Enhanced Supported Nucleoli,Cytosol No No 1100000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoli, Cytosol" "HPA026435: AB_1854151, HPA026502: AB_1854152" "unprognostic (3.49e-2)" "unprognostic (2.39e-2)" "unprognostic (1.78e-1)" "unprognostic (3.44e-2)" "unprognostic (2.86e-1)" "unprognostic (3.25e-2)" "unprognostic (9.67e-3)" "prognostic unfavorable (6.23e-6)" "unprognostic (5.45e-2)" "unprognostic (1.13e-1)" "prognostic unfavorable (5.81e-4)" "unprognostic (9.62e-2)" "prognostic favorable (6.91e-5)" "unprognostic (3.10e-2)" "unprognostic (4.49e-2)" "unprognostic (3.88e-2)" "unprognostic (1.12e-2)" 71.4 32.4 30.9 49.0 32.6 58.0 60.9 34.3 34.4 99.1 49.4 75.1 83.0 53.9 58.4 167.9 50.7 55.8 49.1 34.2 29.0 77.0 32.4 54.1 67.0 29.0 35.5 44.2 48.0 42.4 31.1 57.5 27.2 49.6 72.3 31.7 70.4 51.2 47.1 154.4 94.4 48.2 28.5 51.5 78.3 36.9 41.3 68.2 55.0 38.8 74.1 86.6 113.9 29.2 161.8 49.4 85.6 79.8 128.6 76.4 121.3 73.8 103.0 100.9 97.7 145.7 212.6 114.1 36.6 92.8 63.1 142.1 80.2 162.3 95.5 286.3 41.2 122.0 59.8 84.2 181.0 124.4 82.8 49.8 253.7 79.3 231.6 106.2 88.2 88.0 45.2 76.6 67.0 70.3 93.5 51.1 76.9 217.3 36.6 116.5 52.5 62.3 98.1 143.2 49.8 71.4 46.7 74.2 103.0 129.7 89.6 119.1 120.0 63.8 46.3 52.8 86.5 74.1 41.7 42.5 99.3 74.0 107.4 5.7 12.7 6.3 5.5 10.9 6.6 6.1 10.2 8.0 10.9 7.9 6.9 5.6 10.9 1.5 13.5 7.1 13.7 6.7 30.9 32.6 34.3 34.4 34.2 29.0 29.0 35.5 27.2 28.5 41.3 29.2 36.2 12.8 27.4 27.7 37.4 70.9 83.6 51.2 20.5 20.3 41.5 33.5 3.0 55.8 55.8 68.0 56.3 39.2 36.9 203.8 25.4 35.8 3.5 74.2 48.7 32.5 42.6 41.4 39.2 55.0 45.9 43.2 65.7 99.6 18.4 49.1 25.0 26.6 28.0 10.1 34.2 86.0 24.4 82.2 57.9 5.9 26.8 58.4 56.9 49.6 47.6 25.5 20.6 35.7 11.1 84.4 96.5 30.5 25.5 60.4 111.8 39.2 51.6 11.0 39.5 47.7 41.0 2.9 21.2 61.9 82.1 20.0 45.5 20.4 59.1 153.3 STK25 "SOK1, YSK1" ENSG00000115694 "Serine/threonine kinase 25" O00506 2 241492670-241509730 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in all" 5 "skeletal muscle: 489.9;tongue: 213.8" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA047147 Uncertain NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" "HPA047147: AB_10966137" "unprognostic (1.75e-1)" "unprognostic (8.29e-2)" "prognostic unfavorable (6.03e-4)" "unprognostic (3.42e-2)" "unprognostic (2.71e-1)" "unprognostic (1.24e-1)" "prognostic unfavorable (3.91e-8)" "unprognostic (6.16e-2)" "unprognostic (7.15e-3)" "unprognostic (1.11e-1)" "unprognostic (2.58e-3)" "unprognostic (1.55e-1)" "unprognostic (2.47e-2)" "unprognostic (2.00e-1)" "unprognostic (1.37e-1)" "unprognostic (3.19e-1)" "unprognostic (4.58e-1)" 53.2 50.6 48.2 37.1 48.9 47.0 52.8 35.8 56.7 59.8 27.8 59.8 36.2 62.9 24.0 62.6 60.5 32.9 69.1 50.4 47.1 56.5 50.0 49.6 36.7 37.5 40.9 59.4 70.3 45.9 65.3 38.7 43.3 55.4 30.5 28.9 48.7 40.2 489.9 53.1 50.5 42.1 30.7 61.6 58.7 48.7 46.4 38.5 71.9 213.8 31.8 60.8 56.7 41.2 75.2 46.9 91.1 114.0 109.9 75.9 140.1 122.3 81.8 90.9 103.4 52.3 64.4 28.5 33.7 163.9 82.3 62.9 130.2 132.9 109.9 107.0 136.4 79.7 98.3 136.6 99.3 48.7 59.0 110.1 93.9 88.3 70.3 111.1 208.7 102.6 125.2 24.6 168.8 78.6 73.0 75.9 127.9 69.5 66.3 121.1 116.2 42.6 79.5 62.4 152.8 70.2 59.4 44.2 77.0 102.7 35.7 85.2 245.7 68.2 83.0 79.1 88.3 50.3 12.1 48.8 66.0 39.6 79.1 17.0 16.3 12.9 17.3 15.5 16.3 15.9 15.9 18.5 15.0 16.9 12.3 11.8 5.8 24.6 19.7 11.8 23.3 12.6 48.2 48.9 35.8 56.7 50.4 47.1 37.5 40.9 43.3 30.7 46.4 41.2 43.6 22.4 41.4 23.2 19.7 25.5 29.0 29.7 19.9 48.7 33.2 39.4 36.3 42.9 24.0 25.8 27.1 82.7 19.8 35.2 27.4 46.0 13.8 18.5 28.4 52.7 35.4 48.6 29.8 34.2 80.7 35.1 36.7 25.4 25.4 40.8 45.7 21.5 45.1 32.0 26.1 40.0 20.3 27.3 25.7 14.4 32.6 20.8 19.6 21.5 47.0 58.9 18.6 16.1 27.5 36.9 74.5 39.9 15.8 37.1 43.4 46.1 16.2 41.1 46.0 41.7 35.3 90.2 54.7 31.7 30.4 52.4 25.4 53.2 44.9 29.9 STK26 "MASK, MST4" ENSG00000134602 "Serine/threonine kinase 26" Q9P289 X 132023302-132075943 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 70.0;epididymis: 56.3" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 55.2;dendritic cells: 42.7;NK-cells: 53.5;Syncytiotrophoblasts: 59.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "MOLT-4: 140.1;U-937: 144.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA059921 Approved Uncertain "Nucleoplasm,Golgi apparatus,Centrosome,Cytosol" Yes No 360000 "Cluster 46: Basophils - DNA binding" "Cluster 34: Non-specific - Transcription" "Cluster 32: U-937 - Innate immune response" "Cluster 47: Cytotrophoblasts - Unknown function" Nucleoplasm "Golgi apparatus, Centrosome, Cytosol" "HPA059921: AB_2684163" "unprognostic (6.53e-2)" "unprognostic (7.83e-2)" "unprognostic (1.77e-1)" "unprognostic (1.02e-3)" "unprognostic (4.42e-1)" "unprognostic (1.03e-2)" "prognostic unfavorable (6.82e-4)" "unprognostic (1.18e-1)" "unprognostic (1.93e-1)" "unprognostic (1.31e-1)" "unprognostic (1.42e-3)" "unprognostic (2.49e-1)" "prognostic unfavorable (6.87e-5)" "unprognostic (4.76e-2)" "unprognostic (1.83e-1)" "unprognostic (1.77e-1)" "unprognostic (2.88e-1)" 6.0 2.5 1.0 15.2 2.7 70.0 6.0 1.7 1.3 6.8 2.5 11.5 9.6 46.6 56.3 13.1 7.4 5.6 1.4 0.7 1.5 3.5 5.2 7.2 26.2 0.8 0.8 2.1 3.7 23.5 5.0 25.2 0.7 20.0 11.6 0.2 7.3 35.8 0.9 7.8 6.9 38.1 0.6 13.2 12.2 2.2 3.8 41.3 3.7 1.2 23.5 11.8 7.4 0.7 32.9 11.3 1.3 0.0 5.2 4.9 72.0 1.0 4.0 0.5 0.6 30.1 29.0 44.6 19.4 7.3 22.1 36.5 80.8 51.1 0.0 39.1 66.6 64.6 25.9 28.4 4.7 135.3 5.1 6.9 30.0 0.1 33.7 15.1 14.2 60.0 29.2 40.4 12.2 29.0 140.1 124.9 64.4 22.0 4.3 99.9 39.7 57.9 32.6 51.8 26.6 29.6 19.2 17.0 0.9 54.9 22.0 35.4 0.3 12.8 13.7 39.0 47.9 31.0 52.0 49.8 11.7 144.8 6.5 59.1 9.5 31.6 22.8 12.4 22.4 14.5 15.2 19.6 11.3 12.6 19.7 20.6 18.2 41.0 22.7 4.2 7.2 20.4 1.0 2.7 1.7 1.3 0.7 1.5 0.8 0.8 0.7 0.6 3.8 0.7 0.9 22.4 15.6 0.0 24.7 0.0 36.4 0.0 6.8 0.0 5.9 10.9 1.3 5.7 8.1 11.0 0.0 55.2 42.7 6.5 3.9 4.5 0.6 7.4 1.8 1.7 1.2 12.8 2.0 7.1 34.7 9.6 15.3 17.9 11.4 0.5 1.4 4.4 11.8 0.0 1.4 4.8 0.0 8.8 0.0 0.4 3.4 17.3 0.0 2.8 13.5 0.0 53.5 0.0 0.2 10.9 4.0 2.2 14.5 33.6 1.9 1.5 6.6 0.0 6.6 6.7 3.6 1.8 2.5 16.1 0.0 59.1 27.4 0.6 6.5 18.2 STK3 "KRS1, MST2" ENSG00000104375 "Serine/threonine kinase 3" Q13188 8 98371228-98942827 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Microglial cells: 152.7;Oligodendrocytes: 189.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Group enriched" "Detected in all" 4 "dendritic cells: 7.9;granulocytes: 8.8;monocytes: 8.5" "Cell line enhanced" "Detected in many" "A-431: 85.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007120, CAB025316" Uncertain Approved "Intermediate filaments,Rods & Rings" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 89: Fibroblasts - ECM organization" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 64: Astrocytes - Nervous system maintenance" "Intermediate filaments, Rods & Rings" "CAB025316: , HPA007120: AB_10601664" "unprognostic (7.88e-3)" "unprognostic (1.96e-1)" "unprognostic (6.57e-2)" "prognostic unfavorable (1.53e-4)" "unprognostic (2.95e-1)" "unprognostic (1.12e-3)" "unprognostic (9.68e-3)" "prognostic unfavorable (4.25e-4)" "unprognostic (6.71e-2)" "unprognostic (9.83e-2)" "prognostic unfavorable (9.21e-5)" "unprognostic (9.16e-2)" "unprognostic (1.03e-1)" "unprognostic (2.27e-1)" "unprognostic (1.29e-1)" "unprognostic (5.86e-2)" "unprognostic (9.72e-2)" 15.1 14.4 5.6 7.9 7.0 3.5 14.1 6.6 7.4 17.4 7.2 13.1 5.5 24.9 14.3 10.2 17.0 14.2 9.1 5.1 6.3 15.6 14.3 11.1 5.5 7.7 6.7 25.0 10.0 16.1 6.4 18.5 7.4 16.5 6.7 12.0 10.7 17.6 11.4 9.6 8.3 17.2 6.3 6.8 8.5 11.4 7.1 5.1 11.9 8.6 5.5 13.6 13.7 7.9 85.3 15.7 16.2 22.0 51.2 25.4 16.4 28.8 25.6 26.3 22.8 11.7 35.7 0.0 25.6 28.7 14.1 33.4 11.4 24.8 42.2 20.5 14.8 22.9 7.2 8.0 17.5 7.7 19.0 17.0 41.9 13.5 36.6 17.2 11.5 13.4 9.8 12.2 19.4 10.7 19.3 9.4 4.9 58.0 6.1 17.1 14.1 7.5 29.9 10.7 4.3 9.6 18.4 21.1 18.2 21.0 17.8 12.3 8.7 17.9 11.5 27.1 16.3 9.8 15.5 6.2 15.9 9.5 29.0 2.0 8.3 4.6 1.3 8.5 1.4 1.8 0.7 1.8 7.9 1.1 1.0 0.6 8.8 2.0 5.4 3.3 0.1 2.8 5.6 7.0 6.6 7.4 5.1 6.3 7.7 6.7 7.4 6.3 7.1 7.9 25.9 38.5 37.4 132.9 6.0 43.7 44.8 25.3 23.3 6.9 29.0 15.5 16.6 31.5 37.7 29.5 14.6 43.6 2.5 11.7 23.5 21.5 118.3 23.7 65.8 31.3 9.1 16.2 34.3 18.9 56.1 39.8 9.7 28.9 17.1 13.3 24.3 23.7 19.2 10.1 33.5 7.8 26.4 17.0 25.1 77.1 91.0 18.6 24.9 152.7 13.8 15.0 3.1 60.3 189.9 24.9 13.1 74.1 6.2 42.1 32.3 25.0 29.0 15.6 39.5 43.8 39.7 16.7 12.6 12.3 40.5 64.7 5.9 47.0 13.8 36.0 STK31 "SgK396, TDRD8" ENSG00000196335 "Serine/threonine kinase 31" Q9BXU1 7 23710203-23832513 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in some" 57 "testis: 64.0" "Group enriched" "Detected in some" 5 "Spermatocytes: 161.5;Spermatogonia: 75.0" "Cancer enhanced" "Detected in some" "testis cancer: 2.1" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 9 "CACO-2: 20.5" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA023194, HPA072896" Enhanced NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 39: CACO-2 - Unknown function" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA023194: AB_1857590, HPA072896: " "unprognostic (4.25e-2)" "unprognostic (1.04e-1)" "unprognostic (3.98e-2)" "unprognostic (5.41e-2)" "unprognostic (1.62e-1)" "unprognostic (1.50e-2)" "unprognostic (1.09e-2)" "unprognostic (1.26e-1)" "unprognostic (1.34e-1)" "unprognostic (1.73e-1)" "unprognostic (2.42e-3)" "unprognostic (2.92e-1)" "unprognostic (1.29e-6)" "unprognostic (7.83e-2)" "unprognostic (9.21e-3)" "unprognostic (1.46e-1)" "unprognostic (3.65e-1)" 0.1 0.1 0.3 0.0 0.4 0.0 0.2 1.1 0.4 0.1 0.2 0.2 0.3 0.1 0.0 0.3 0.2 0.1 0.1 0.3 0.4 0.3 0.3 0.4 0.0 0.6 0.4 0.2 0.4 0.0 0.1 0.0 0.7 0.2 0.0 0.2 0.2 0.0 0.0 0.2 0.3 0.0 0.3 0.2 0.4 64.0 0.4 0.1 0.2 0.0 0.0 0.1 0.1 0.6 0.2 0.7 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 20.5 2.3 0.0 2.3 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.4 1.1 0.4 0.3 0.4 0.6 0.4 0.7 0.3 0.4 0.6 0.4 3.2 1.1 2.9 0.3 0.1 0.2 0.5 0.0 2.0 1.0 0.1 0.6 1.5 2.8 0.0 0.0 0.6 0.1 0.3 0.0 0.2 21.1 0.6 0.0 0.4 1.2 0.0 2.9 0.6 0.1 0.6 2.0 0.2 0.0 0.3 0.0 0.5 0.2 0.0 4.6 0.4 2.0 0.0 0.0 19.6 3.4 0.5 0.0 2.8 0.0 1.0 0.0 2.5 12.7 0.4 5.3 3.0 0.5 0.3 0.8 0.1 4.3 1.2 0.0 0.6 0.1 161.5 75.0 0.0 0.1 0.5 0.5 0.1 0.5 0.5 STK32A "MGC22688, YANK1" ENSG00000169302 "Serine/threonine kinase 32A" Q8WU08 5 147234963-147387855 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "adrenal gland: 11.2;brain: 24.4" "Cell type enriched" "Detected in many" 19 "Oligodendrocyte precursor cells: 306.6" "Group enriched" "Detected in many" 5 "glioma: 4.3;melanoma: 11.9;thyroid cancer: 9.0" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 5 "RT4: 13.6;SK-MEL-30: 48.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040236 Approved Centrosome NA NA "Cluster 73: Brain - Neuropeptide signaling" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 68: Oligodendrocytes - Mixed function" Centrosome "HPA040236: AB_10795416" "unprognostic (1.90e-1)" "unprognostic (4.71e-4)" "unprognostic (5.32e-2)" "unprognostic (3.49e-2)" "unprognostic (7.62e-2)" "unprognostic (6.82e-2)" "unprognostic (2.66e-2)" "unprognostic (2.96e-3)" "unprognostic (4.85e-2)" "unprognostic (2.36e-2)" "unprognostic (3.87e-1)" "unprognostic (8.38e-2)" "unprognostic (2.50e-3)" "unprognostic (5.53e-5)" "unprognostic (2.48e-1)" "unprognostic (3.20e-2)" "unprognostic (3.67e-3)" 1.3 11.2 5.9 0.6 9.5 0.0 1.2 13.2 3.1 1.0 1.0 2.3 0.5 0.5 2.6 0.3 0.8 1.5 1.0 3.5 14.4 3.4 0.1 1.2 0.0 11.7 24.4 2.5 2.6 0.1 8.1 0.1 17.0 1.0 0.3 2.6 0.9 0.8 0.2 3.7 0.7 0.4 10.4 0.3 1.2 1.0 14.0 0.1 8.7 0.5 0.0 1.7 1.0 10.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.5 0.0 1.4 0.0 0.0 0.0 0.1 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.1 0.0 0.0 0.0 6.5 0.0 0.0 0.0 0.0 0.5 0.0 1.1 0.0 0.0 0.2 4.4 13.6 1.2 0.5 0.0 0.0 48.6 0.2 0.0 0.0 0.1 0.0 0.5 0.7 0.4 1.0 0.2 0.0 1.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.9 9.5 13.2 3.1 3.5 14.4 11.7 24.4 17.0 10.4 14.0 10.1 0.2 0.0 2.6 8.5 0.0 1.5 0.2 1.4 0.0 1.8 1.3 0.5 0.5 0.0 1.0 1.8 0.0 0.0 0.0 0.1 1.9 1.8 6.9 0.2 0.5 0.1 0.0 0.0 4.6 2.7 0.0 2.7 0.0 0.7 0.0 4.2 0.0 0.0 0.1 0.0 5.2 0.0 2.0 0.0 1.0 10.5 0.9 0.2 16.0 0.0 0.0 4.0 0.0 306.6 0.7 5.5 0.0 4.1 0.0 0.3 0.0 4.1 0.2 1.0 0.0 5.4 0.5 0.0 0.1 0.0 0.3 0.1 0.1 1.4 0.0 0.6 STK32B "HSA250839, STK32, STKG6, YANK2" ENSG00000152953 "Serine/threonine kinase 32B" Q9NY57 4 5051480-5500994 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "kidney: 15.0;lymphoid tissue: 19.5" "Cell type enhanced" "Detected in many" "Early spermatids: 108.2;Late spermatids: 39.3;Microglial cells: 27.2;Oligodendrocyte precursor cells: 169.4" "Cancer enhanced" "Detected in many" "renal cancer: 6.8" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "GAMG: 27.5;HUVEC TERT2: 27.5;REH: 25.2;U-2197: 43.8;WM-115: 112.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA015820 Approved "Nucleoplasm,Nuclear bodies,Cytosol" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 3: T-cells - Adaptive immune response" "Cluster 17: WM-115 - Nervous system development" "Cluster 68: Oligodendrocytes - Mixed function" "Nucleoplasm, Nuclear bodies" Cytosol "HPA015820: AB_1858913" "unprognostic (4.48e-2)" "unprognostic (1.02e-1)" "unprognostic (6.08e-2)" "unprognostic (1.35e-1)" "unprognostic (8.12e-3)" "unprognostic (9.96e-2)" "unprognostic (1.64e-4)" "unprognostic (1.27e-1)" "unprognostic (1.27e-1)" "unprognostic (1.70e-1)" "unprognostic (2.54e-1)" "unprognostic (8.82e-2)" "prognostic favorable (1.63e-8)" "unprognostic (8.10e-3)" "unprognostic (5.04e-2)" "unprognostic (3.62e-2)" "unprognostic (1.67e-3)" 3.5 0.3 2.3 1.2 7.8 1.5 4.3 1.9 2.3 3.3 1.5 1.1 0.5 3.5 0.3 1.2 1.3 1.4 0.4 2.1 4.5 15.0 0.1 0.9 1.8 3.7 3.9 0.6 1.8 0.3 0.4 3.2 3.7 0.6 1.1 0.8 1.0 0.9 1.3 2.4 1.1 2.5 3.6 0.2 6.0 4.5 3.5 19.5 1.7 1.7 1.0 3.1 1.5 3.6 0.0 14.0 0.8 0.0 0.6 1.0 0.0 9.7 1.1 6.3 0.2 0.1 0.0 0.0 2.1 19.7 27.5 0.1 1.5 0.0 2.3 0.0 0.0 0.1 6.4 0.0 0.0 0.0 0.0 0.0 0.0 5.0 0.2 0.2 27.5 1.4 0.0 0.1 3.4 0.0 0.0 2.0 4.1 0.0 0.0 25.2 0.1 0.0 6.2 0.0 0.4 0.0 0.0 0.1 8.5 0.6 0.0 0.0 7.1 0.2 2.8 43.8 0.0 0.9 0.1 0.0 0.1 0.0 112.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 2.3 7.8 1.9 2.3 2.1 4.5 3.7 3.9 3.7 3.6 3.5 3.6 3.6 0.0 1.1 1.6 0.0 2.3 0.2 0.0 0.0 0.0 4.2 1.7 0.4 0.0 0.0 0.0 0.0 0.0 1.5 0.0 17.6 1.1 108.2 0.2 0.1 3.2 0.0 0.0 3.7 0.0 0.1 5.5 4.1 0.3 0.0 0.0 0.0 0.0 1.7 0.0 14.4 0.0 0.0 0.0 1.2 39.3 1.5 1.1 5.4 27.2 0.5 0.0 0.0 169.4 1.3 0.4 0.0 1.2 0.0 0.1 0.0 18.9 0.0 0.0 0.0 0.6 0.4 1.2 5.5 0.0 1.0 0.0 0.2 0.4 0.0 0.1 STK32C "MGC23665, PKE, YANK3" ENSG00000165752 "Serine/threonine kinase 32C" Q86UX6 10 132207492-132331847 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 54.1" "Group enriched" "Detected in many" 4 "Early spermatids: 278.9;Late spermatids: 83.3;Spermatocytes: 89.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 55.3" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017894 Uncertain NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 78: Testis - Spermatogenesis" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 29: Early spermatids - Spermatogenesis" "HPA017894: AB_1857591" "unprognostic (2.11e-1)" "unprognostic (8.40e-2)" "unprognostic (4.80e-3)" "prognostic unfavorable (1.09e-4)" "unprognostic (1.65e-2)" "unprognostic (5.52e-2)" "prognostic unfavorable (1.68e-6)" "unprognostic (2.03e-1)" "unprognostic (7.79e-2)" "unprognostic (2.14e-1)" "unprognostic (1.18e-2)" "unprognostic (1.13e-1)" "prognostic unfavorable (5.31e-6)" "unprognostic (8.65e-2)" "unprognostic (3.20e-1)" "unprognostic (5.05e-2)" "unprognostic (1.36e-1)" 11.0 12.5 31.4 7.1 39.6 7.6 8.9 17.8 37.5 8.1 13.5 9.1 5.2 6.9 14.8 5.4 9.4 6.5 7.4 31.3 23.2 15.6 5.0 8.8 10.0 24.6 26.1 6.7 7.4 6.0 12.3 4.9 20.5 6.6 4.7 7.9 5.7 5.2 13.7 7.6 6.8 5.0 23.4 15.1 6.2 54.1 30.9 10.8 6.4 9.1 6.4 8.3 6.5 25.9 69.4 43.5 13.3 33.5 18.4 23.3 2.7 14.1 10.7 17.4 22.2 10.0 46.0 14.8 10.3 16.4 22.0 14.9 18.6 5.5 16.9 8.9 31.1 8.9 46.1 47.1 22.9 7.9 31.1 17.6 20.8 15.7 17.3 22.0 15.6 25.1 15.4 10.2 19.0 21.1 10.4 30.4 8.8 12.6 31.4 12.2 8.2 4.9 23.3 11.7 34.6 27.3 10.2 9.3 20.9 7.9 10.5 19.2 10.6 13.6 14.2 18.2 11.3 19.1 3.8 38.7 31.4 7.4 7.1 55.3 17.9 16.5 5.8 19.6 7.3 6.2 4.7 6.6 25.1 10.2 5.8 4.5 2.4 6.1 17.3 14.5 9.2 7.0 31.4 39.6 17.8 37.5 31.3 23.2 24.6 26.1 20.5 23.4 30.9 25.9 6.6 0.0 7.2 13.4 7.3 5.2 6.8 5.7 4.6 8.4 10.3 11.0 3.7 2.8 6.1 12.9 12.5 3.4 9.3 3.2 19.6 5.4 278.9 25.9 8.2 8.2 19.2 15.8 22.9 8.7 2.3 7.2 6.6 11.8 15.8 6.0 13.6 5.5 14.6 37.0 13.9 7.4 12.2 24.3 28.5 83.3 9.0 14.8 12.4 7.5 14.0 11.0 6.2 9.5 10.0 6.0 5.1 6.8 4.8 11.4 3.8 13.2 13.7 14.6 6.6 10.5 5.6 89.8 20.0 5.9 5.1 1.5 9.3 10.1 7.6 7.3 STK33 ENSG00000130413 "Serine/threonine kinase 33" Q9BYT3 11 8391868-8594289 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "choroid plexus: 49.3;testis: 51.8" "Cell type enhanced" "Detected in many" "Astrocytes: 213.8;Early spermatids: 98.8;Endometrial ciliated cells: 220.9;Late spermatids: 157.0;Oligodendrocyte precursor cells: 117.6;Respiratory ciliated cells: 155.3;Spermatocytes: 148.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 4 "memory B-cell: 4.1;naive B-cell: 2.2" "Lineage enriched" "Detected in single" 5 "B-cells: 4.1" "Cell line enhanced" "Detected in many" "Daudi: 23.0;hTERT-RPE1: 22.0;Karpas-707: 21.2;SCLC-21H: 22.9;U-251 MG: 24.3;U-266/84: 21.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA015742, HPA056855" Uncertain Approved Nucleoplasm,Nucleoli,Cytosol NA NA "Cluster 37: B-cells - Transcription" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 49: Ciliated cells - Cilium organization" Nucleoplasm "Nucleoli, Cytosol" "HPA015742: AB_1857592, HPA056855: AB_2683257" "unprognostic (2.57e-2)" "unprognostic (2.80e-1)" "unprognostic (2.23e-3)" "unprognostic (2.76e-3)" "unprognostic (3.57e-1)" "unprognostic (1.40e-1)" "unprognostic (7.28e-2)" "unprognostic (3.85e-4)" "unprognostic (1.23e-1)" "unprognostic (8.06e-2)" "unprognostic (1.33e-3)" "unprognostic (9.46e-2)" "prognostic favorable (4.89e-6)" "unprognostic (2.39e-2)" "unprognostic (1.37e-1)" "unprognostic (3.49e-2)" "unprognostic (2.90e-2)" 1.3 8.1 6.7 2.0 6.6 1.3 0.5 8.5 4.9 5.6 49.3 8.3 3.3 12.0 11.3 2.7 42.3 5.1 16.2 6.1 10.1 10.2 0.4 7.1 2.0 14.7 15.6 13.4 6.5 23.1 24.1 0.1 13.3 6.4 1.5 15.6 2.1 11.5 3.9 0.2 3.4 9.3 12.0 1.5 6.0 51.8 12.8 3.8 20.0 6.0 2.2 3.4 1.7 8.3 0.0 3.4 15.4 0.0 0.0 0.0 0.0 3.0 3.1 7.0 6.2 2.2 0.0 23.0 11.5 0.6 8.7 0.0 6.9 2.5 6.0 0.0 18.9 0.0 4.2 5.6 2.5 13.4 0.0 1.1 0.0 0.2 0.0 22.0 0.5 11.2 0.0 21.2 0.3 0.0 0.4 0.0 11.2 0.0 0.0 8.8 2.2 14.3 6.1 0.0 22.9 6.2 0.0 0.0 0.1 4.3 0.0 1.3 0.0 0.0 10.6 0.2 24.3 5.1 21.2 0.3 6.8 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 4.1 0.0 0.7 0.0 2.2 0.0 0.6 0.0 0.1 0.0 0.4 0.1 0.2 6.7 6.6 8.5 4.9 6.1 10.1 14.7 15.6 13.3 12.0 12.8 8.3 0.1 19.2 14.5 213.8 6.2 0.0 1.3 1.9 0.0 20.7 0.1 0.3 37.8 8.6 27.5 20.2 70.9 0.1 1.4 0.2 3.9 9.5 98.8 220.9 5.5 1.8 9.1 1.7 12.0 4.9 3.3 5.0 6.1 17.8 1.3 29.3 0.4 0.0 0.3 1.7 15.4 1.6 6.1 0.0 0.0 157.0 4.4 0.6 0.0 23.4 0.0 31.0 0.0 117.6 19.7 4.4 0.4 17.0 5.2 0.5 3.6 13.5 155.3 77.4 0.0 0.2 2.7 148.3 26.8 0.2 0.0 0.0 1.3 6.3 3.5 0.0 STK35 "bA550O8.2, CLIK1" ENSG00000125834 "Serine/threonine kinase 35" Q8TDR2 20 2101827-2177038 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 6 "retina: 118.8" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 150.1;Early spermatids: 214.3;Horizontal cells: 294.4;Late spermatids: 821.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026452, HPA051673" Approved Supported "Nucleoplasm,Nuclear bodies" NA NA "Cluster 30: Non-specific - Translation" "Cluster 77: Retina - Visual perception" "Cluster 39: CACO-2 - Unknown function" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoplasm, Nuclear bodies" "HPA026452: AB_2671861, HPA051673: AB_2681569" "unprognostic (2.25e-2)" "unprognostic (2.97e-1)" "unprognostic (2.87e-2)" "unprognostic (1.30e-2)" "unprognostic (3.25e-1)" "unprognostic (2.28e-1)" "prognostic unfavorable (9.46e-6)" "unprognostic (6.53e-2)" "unprognostic (1.82e-1)" "unprognostic (3.05e-2)" "unprognostic (1.37e-1)" "unprognostic (2.07e-1)" "unprognostic (4.39e-2)" "unprognostic (1.74e-1)" "unprognostic (4.67e-1)" "unprognostic (1.40e-1)" "unprognostic (4.99e-2)" 9.0 11.3 9.4 6.6 8.3 8.6 7.9 6.7 13.0 7.3 5.1 10.2 7.1 9.7 5.8 15.6 8.6 7.1 10.0 9.5 8.3 6.9 8.9 8.5 6.4 6.2 10.6 8.0 9.3 7.8 9.7 6.2 7.3 8.0 8.2 118.8 8.7 6.3 6.5 11.3 9.3 7.8 5.0 8.3 8.7 18.3 15.4 6.4 8.5 5.7 7.6 8.1 8.9 8.6 23.3 19.4 14.7 25.4 6.7 9.1 17.9 9.3 11.4 12.2 12.5 25.6 17.5 15.9 7.5 11.7 19.0 34.1 17.6 21.4 13.8 6.3 8.4 15.2 7.4 28.1 8.5 13.7 6.8 7.9 18.5 19.5 16.7 11.2 11.7 15.0 14.9 12.8 8.0 10.3 17.4 19.4 27.5 18.4 12.9 14.9 13.2 10.1 11.1 22.9 24.3 11.8 16.6 29.3 15.0 17.0 14.5 13.5 10.0 20.7 14.1 10.5 14.9 11.1 15.5 10.8 11.1 14.7 9.2 0.0 0.3 0.1 0.4 0.2 0.6 0.3 0.6 0.3 0.5 0.4 0.5 0.4 0.7 0.2 0.3 0.4 0.2 0.3 9.4 8.3 6.7 13.0 9.5 8.3 6.2 10.6 7.3 5.0 15.4 8.6 8.8 12.8 9.8 4.9 6.3 11.6 4.4 7.5 13.1 111.8 10.9 9.5 12.2 2.8 9.1 3.7 150.1 7.2 7.5 15.4 1.9 6.4 214.3 15.7 7.8 9.1 6.1 12.0 11.8 6.8 11.5 11.1 11.2 12.7 9.5 8.4 7.9 10.3 5.7 294.4 11.6 7.6 10.2 6.3 4.9 821.8 6.8 5.7 7.2 11.2 4.0 124.7 5.2 9.0 11.2 10.4 9.7 6.0 8.5 6.7 8.8 3.6 10.2 96.7 0.0 10.8 7.2 15.5 14.4 12.4 11.8 5.7 6.0 4.5 10.9 6.6 STK36 "FU, KIAA1278" ENSG00000163482 "Serine/threonine kinase 36" Q9NRP7 2 218672069-218702716 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cilium biogenesis/degradation" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 37.5;Respiratory ciliated cells: 38.2;Spermatocytes: 28.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027409, HPA027453, HPA030058" Approved Supported Cytosol NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 20: HeLa - Mitochondria" "Cluster 49: Ciliated cells - Cilium organization" Cytosol "HPA027409: AB_10600223, HPA027453: AB_10601893, HPA030058: AB_10601225" "unprognostic (8.11e-2)" "unprognostic (3.77e-1)" "unprognostic (3.59e-2)" "unprognostic (1.27e-1)" "unprognostic (1.50e-1)" "unprognostic (2.52e-2)" "prognostic unfavorable (5.20e-4)" "unprognostic (1.55e-1)" "unprognostic (5.83e-3)" "unprognostic (9.04e-2)" "unprognostic (1.38e-2)" "unprognostic (1.13e-2)" "unprognostic (3.52e-3)" "unprognostic (1.46e-1)" "unprognostic (2.60e-2)" "unprognostic (1.77e-1)" "unprognostic (1.99e-3)" 5.6 9.9 1.5 5.4 1.7 2.5 6.6 1.0 3.2 14.1 15.4 9.0 4.4 11.4 13.4 5.1 14.3 10.5 3.5 2.3 1.0 7.3 4.5 7.3 4.5 1.2 2.6 13.4 10.7 9.4 14.8 4.3 0.8 9.6 6.5 11.6 7.3 8.2 3.7 5.0 6.4 8.0 0.3 5.1 8.8 32.0 1.3 3.2 11.8 2.3 4.0 8.2 7.6 1.0 3.7 8.2 17.6 15.0 18.7 14.5 10.9 9.8 7.8 12.2 11.4 10.7 6.0 4.8 13.3 10.3 8.2 7.2 12.2 10.3 10.7 2.8 10.2 4.7 27.1 15.0 9.1 6.7 7.6 15.7 7.5 12.0 8.4 32.3 9.3 6.2 11.1 6.0 10.3 8.5 4.0 8.5 10.7 4.6 5.2 7.3 7.6 5.1 14.9 18.2 14.2 12.3 7.6 12.2 5.0 18.2 12.4 5.3 8.9 16.8 6.1 6.5 6.8 7.5 6.3 2.5 10.4 3.1 7.1 0.0 0.4 0.7 0.3 0.2 0.1 0.4 0.2 0.2 0.3 0.1 0.2 0.3 0.0 0.5 0.3 0.3 0.2 0.4 1.5 1.7 1.0 3.2 2.3 1.0 1.2 2.6 0.8 0.3 1.3 1.0 2.1 9.6 6.3 18.3 1.6 1.1 0.9 3.6 2.8 7.4 7.4 5.5 4.0 5.7 3.7 3.7 37.5 1.8 2.9 2.9 0.0 3.7 16.9 17.5 9.0 3.3 2.4 0.8 22.0 2.5 1.5 4.5 10.7 6.3 1.3 12.2 3.3 5.9 2.7 1.7 18.0 4.4 6.1 2.5 1.2 6.0 5.9 2.0 0.0 2.8 2.5 4.9 1.0 8.5 6.2 2.2 5.0 4.9 0.6 1.6 2.5 4.4 38.2 9.1 6.6 3.1 4.0 28.0 8.9 3.7 1.0 0.8 1.5 11.0 4.9 0.9 STK38 "NDR, NDR1" ENSG00000112079 "Serine/threonine kinase 38" Q15208 6 36493892-36547479 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "NK-cells: 101.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004673, HPA038623, HPA051324" Uncertain Approved Cytosol NA NA "Cluster 38: Basophils - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 63: NK-cells & T-cells - Immune response" Cytosol "CAB004673: AB_425892, HPA038623: AB_10967059, HPA051324: AB_2681442" "unprognostic (3.58e-3)" "unprognostic (1.80e-2)" "unprognostic (3.07e-2)" "unprognostic (6.76e-3)" "unprognostic (8.25e-2)" "unprognostic (1.47e-2)" "unprognostic (2.88e-3)" "unprognostic (2.08e-1)" "prognostic unfavorable (9.44e-5)" "unprognostic (3.78e-2)" "unprognostic (2.18e-1)" "unprognostic (3.21e-2)" "unprognostic (1.98e-2)" "unprognostic (3.80e-1)" "unprognostic (2.59e-1)" "unprognostic (1.69e-1)" "unprognostic (3.13e-3)" 27.6 11.5 13.2 28.9 13.6 30.6 23.2 15.8 18.1 23.5 15.2 40.4 24.0 21.3 12.5 39.6 21.4 20.7 24.2 14.2 13.4 23.1 24.7 24.9 34.5 14.4 13.4 16.0 12.5 8.3 14.4 21.7 13.6 23.8 36.5 11.3 33.6 16.0 16.1 30.6 41.6 27.4 13.0 34.6 23.2 13.8 14.8 28.0 14.0 16.2 33.8 30.0 28.4 14.2 43.0 31.1 32.1 34.8 63.4 47.9 27.9 46.7 37.6 47.6 47.4 24.0 28.7 57.3 35.3 70.0 39.5 44.7 26.9 19.6 55.7 23.6 23.0 41.1 40.8 21.9 31.2 15.8 21.7 31.9 50.0 36.9 23.6 54.5 30.1 28.7 34.0 32.4 68.5 25.7 25.5 40.8 13.4 50.5 27.3 97.7 38.9 15.3 45.0 52.9 37.4 17.7 57.0 25.9 34.0 35.7 27.8 40.8 29.4 38.4 33.6 30.9 30.7 27.1 51.4 39.9 8.7 60.1 37.8 91.2 45.2 34.6 57.0 49.5 44.1 22.4 46.9 50.4 29.1 16.2 41.1 45.8 59.4 59.3 73.3 14.4 48.7 58.3 13.2 13.6 15.8 18.1 14.2 13.4 14.4 13.4 13.6 13.0 14.8 14.2 29.7 19.2 16.0 27.4 25.7 13.5 9.6 21.5 21.1 3.0 16.0 14.5 15.5 18.6 47.9 7.3 0.0 13.8 59.5 47.1 1.9 18.9 9.0 15.3 16.0 18.4 14.4 16.6 46.5 12.7 17.8 22.2 34.7 20.4 13.3 13.5 12.1 15.0 13.2 5.0 34.2 25.4 22.4 38.2 20.3 5.3 27.1 40.1 17.8 57.1 48.7 7.6 101.0 38.2 36.8 27.8 30.8 30.1 39.6 12.8 32.8 16.6 40.4 7.7 13.1 8.3 14.0 26.5 10.3 31.5 21.2 15.3 45.5 10.1 28.4 27.9 STK38L "KIAA0965, NDR2" ENSG00000211455 "Serine/threonine kinase 38 like" Q9Y2H1 12 27243968-27325959 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Actin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Group enriched" "Detected in all" 5 "dendritic cells: 49.9;granulocytes: 80.7;monocytes: 33.0" "Cell line enhanced" "Detected in all" "HDLM-2: 157.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038623, HPA051324" Approved Approved Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 46: Fibroblasts - ECM organization" "Cluster 44: HDLM-2 - Immune response" "Cluster 1: Pancreatic cells - Digestion" Cytosol "HPA038623: AB_10967059, HPA051324: AB_2681442" "unprognostic (2.14e-2)" "unprognostic (1.01e-1)" "unprognostic (9.94e-2)" "unprognostic (2.43e-2)" "unprognostic (2.02e-1)" "unprognostic (1.76e-1)" "unprognostic (3.33e-2)" "unprognostic (4.68e-2)" "unprognostic (5.56e-2)" "unprognostic (1.56e-1)" "prognostic unfavorable (5.82e-4)" "unprognostic (1.16e-1)" "unprognostic (3.41e-2)" "unprognostic (1.09e-1)" "unprognostic (1.95e-1)" "unprognostic (5.05e-2)" "unprognostic (1.05e-2)" 23.9 11.6 6.5 21.6 8.6 17.2 14.0 6.9 11.1 17.2 6.4 28.9 12.9 27.1 7.5 22.7 15.1 25.7 44.9 6.7 8.6 12.9 12.5 12.3 12.4 8.1 7.5 7.0 12.3 26.9 7.2 15.7 8.4 20.2 21.2 6.6 13.8 15.0 8.8 10.8 14.3 33.3 7.6 12.0 18.6 11.2 9.5 17.8 9.2 16.4 14.8 24.6 15.5 6.8 12.0 15.7 40.1 17.7 18.6 12.4 30.8 7.7 11.5 4.8 6.5 19.8 8.5 29.3 17.7 6.4 13.6 21.9 19.0 13.4 7.2 157.8 17.3 18.7 17.5 10.0 15.5 43.7 19.7 14.7 13.3 17.6 21.7 29.3 38.1 36.8 21.2 21.1 9.7 8.3 28.5 46.3 49.6 31.2 25.4 10.6 47.8 22.4 6.8 22.0 6.7 22.3 33.1 19.9 13.3 38.6 9.8 14.0 16.4 15.5 13.9 23.7 20.3 7.7 8.1 29.1 8.0 19.9 6.7 16.3 33.0 60.8 10.0 28.4 7.0 11.6 7.7 9.8 49.9 9.3 9.4 7.6 80.7 11.6 22.4 21.2 10.8 14.7 6.5 8.6 6.9 11.1 6.7 8.6 8.1 7.5 8.4 7.6 9.5 6.8 24.4 19.2 16.2 32.7 20.8 35.4 36.3 88.2 22.2 12.7 16.2 14.7 76.0 10.0 33.7 9.2 2.1 11.0 21.7 33.6 9.8 49.8 23.1 12.5 15.3 26.2 19.2 15.4 57.2 40.1 9.1 19.7 15.3 14.9 17.7 10.9 24.3 14.5 28.8 10.1 37.5 33.8 18.3 36.4 73.7 5.9 6.5 45.7 21.4 37.5 46.2 8.1 14.4 42.3 16.0 70.5 26.3 12.0 22.8 24.8 9.2 16.2 11.9 7.9 19.7 8.6 41.1 12.1 13.4 20.5 32.0 27.8 15.7 9.7 23.0 42.0 STK39 "DCHT, SPAK" ENSG00000198648 "Serine/threonine kinase 39" Q9UEW8 2 167954020-168247595 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 159.9;Inhibitory neurons: 142.9;Oligodendrocyte precursor cells: 153.3;Oligodendrocytes: 359.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB046022, HPA061803, HPA062802" Enhanced Supported Nucleoplasm,Vesicles,Cytosol NA NA 80000 "Cluster 35: T-regs - Unknown function" "Cluster 22: Non-specific - Unknown function" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "Vesicles, Cytosol" "CAB046022: AB_2196960, HPA061803: AB_2684616, HPA062802: AB_2684870" "prognostic favorable (3.96e-4)" "unprognostic (2.97e-2)" "unprognostic (4.40e-2)" "unprognostic (4.22e-2)" "unprognostic (4.36e-1)" "unprognostic (6.14e-2)" "prognostic unfavorable (5.67e-5)" "unprognostic (3.04e-2)" "unprognostic (8.86e-2)" "unprognostic (9.43e-2)" "unprognostic (3.20e-2)" "unprognostic (1.38e-1)" "unprognostic (2.06e-1)" "unprognostic (9.45e-2)" "unprognostic (8.61e-3)" "unprognostic (1.14e-1)" "unprognostic (6.20e-3)" 19.4 6.7 20.1 14.0 25.8 5.1 8.4 25.3 25.1 12.0 52.9 26.3 32.0 7.3 14.5 36.3 6.4 18.1 15.8 16.0 18.6 9.0 1.9 7.6 22.2 28.8 25.8 6.6 25.6 13.7 8.2 2.3 31.9 28.7 32.4 27.8 67.9 11.5 2.7 6.3 18.6 11.7 20.8 8.6 31.8 48.5 25.6 29.1 6.9 7.6 23.5 24.8 9.5 37.0 19.1 10.9 40.9 12.9 28.1 37.5 4.0 45.0 33.8 29.6 27.8 0.2 59.9 51.1 12.2 30.5 25.5 46.6 26.7 34.4 37.1 16.2 16.4 21.2 11.8 42.9 52.3 30.5 2.1 29.1 52.8 35.1 36.5 38.5 21.2 41.3 0.5 0.0 67.0 11.4 51.6 13.0 30.3 41.0 24.3 72.1 16.0 4.8 27.9 47.6 65.7 27.0 15.7 2.6 21.8 20.3 8.0 25.9 20.2 36.6 11.1 26.5 32.2 0.1 0.0 41.5 29.7 28.5 25.1 0.0 0.3 0.0 1.1 0.2 0.6 0.2 0.9 1.6 0.5 0.5 0.2 0.8 0.0 1.0 0.1 0.1 1.8 0.2 20.1 25.8 25.3 25.1 16.0 18.6 28.8 25.8 31.9 20.8 25.6 37.0 6.1 3.2 14.0 64.6 6.4 3.8 34.4 6.5 5.7 14.8 5.5 6.5 26.2 18.6 15.2 5.5 16.7 0.1 30.0 47.7 21.5 10.9 29.4 11.9 11.6 5.6 22.8 5.7 159.9 23.1 0.1 9.2 28.1 18.9 0.0 5.8 2.9 0.4 3.5 20.2 142.9 17.3 14.2 6.7 6.7 16.2 10.2 6.7 17.8 64.6 5.5 28.9 12.3 153.3 359.4 36.0 20.1 11.3 9.5 74.8 14.5 7.9 17.5 30.0 6.6 7.7 18.2 25.4 8.1 7.5 4.4 0.3 19.4 15.8 22.4 50.6 STK4 "KRS2, MST1, YSK3" ENSG00000101109 "Serine/threonine kinase 4" Q13043 20 44966479-45080021 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" Apoptosis "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 57.7" "Cell type enhanced" "Detected in all" "B-cells: 372.8;dendritic cells: 341.8;Langerhans cells: 606.9;monocytes: 367.5;Plasma cells: 336.2;T-cells: 414.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004038, HPA015270" Approved Supported "Nucleoplasm,Nuclear bodies,Cytosol" NA NA 45000 "Cluster 18: Basophils - Vesicular transport" "Cluster 66: Lymphoid tissue - Immune response regulation" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 24: Non-specific - Transcription regulation" "Nuclear bodies" "Nucleoplasm, Cytosol" "CAB004038: AB_2144632, HPA015270: AB_1854150" "unprognostic (2.77e-1)" "unprognostic (1.10e-1)" "unprognostic (8.83e-2)" "unprognostic (8.49e-3)" "unprognostic (2.95e-2)" "unprognostic (1.24e-1)" "prognostic unfavorable (8.04e-4)" "unprognostic (1.70e-1)" "unprognostic (2.51e-1)" "unprognostic (1.05e-1)" "unprognostic (1.96e-1)" "unprognostic (2.70e-2)" "prognostic unfavorable (1.84e-5)" "unprognostic (1.28e-1)" "unprognostic (5.70e-2)" "unprognostic (3.96e-1)" "unprognostic (1.18e-2)" 10.0 8.5 6.9 33.8 8.0 57.7 9.1 6.2 10.8 7.9 9.9 11.1 10.2 8.5 7.6 9.1 6.2 11.7 4.6 7.2 8.7 6.0 9.2 15.9 43.1 8.7 7.6 7.0 6.0 5.9 4.1 10.4 9.2 6.7 13.0 7.3 7.4 8.0 3.3 11.2 13.5 9.3 8.3 30.4 12.7 9.7 7.5 33.1 7.6 4.9 41.7 15.0 6.9 10.3 27.8 18.7 23.3 16.1 13.5 16.9 16.0 23.6 35.7 39.4 35.6 52.7 14.6 66.6 20.4 16.9 33.4 28.5 24.3 31.8 49.7 30.8 13.8 48.6 27.8 36.8 23.8 63.5 66.4 13.8 25.6 36.7 39.6 19.4 14.6 44.6 23.5 37.0 19.9 21.7 47.6 42.3 13.9 17.7 12.5 30.2 25.2 31.2 14.4 18.7 10.9 13.2 35.6 20.0 27.0 17.2 18.3 39.1 18.7 29.2 28.6 34.4 27.8 48.4 41.7 73.2 28.6 29.5 22.0 80.6 19.7 54.8 34.4 19.9 34.3 26.2 32.2 32.0 18.4 26.9 33.1 28.0 101.8 28.5 38.0 10.0 34.3 22.3 6.9 8.0 6.2 10.8 7.2 8.7 8.7 7.6 9.2 8.3 7.5 10.3 26.2 16.0 24.6 18.9 372.8 55.7 49.3 33.8 28.5 27.3 22.9 17.4 7.6 14.3 25.2 42.3 52.1 24.1 341.8 23.7 9.8 16.3 5.9 19.1 25.1 32.1 25.7 46.3 76.7 17.6 30.3 29.7 34.1 25.1 133.6 114.0 26.0 22.0 61.1 43.7 38.2 20.7 28.5 109.3 606.9 5.0 22.7 154.4 133.4 85.3 367.5 20.2 278.1 34.2 48.1 21.6 27.9 17.0 336.2 32.6 23.2 13.4 26.1 69.9 13.1 25.5 29.2 44.2 42.4 20.9 53.0 19.4 414.5 48.1 19.5 45.5 STK40 "MGC4796, SgK495" ENSG00000196182 "Serine/threonine kinase 40" Q8N2I9 1 36339624-36385924 "Enzymes, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 116.7;Late spermatids: 236.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 25.2" "Group enriched" "Detected in all" 5 "granulocytes: 25.2;monocytes: 12.0" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA008026 Uncertain Supported Nucleoplasm,Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 59: Non-specific - Translation" "Cluster 17: WM-115 - Nervous system development" "Cluster 31: Spermatids - Spermatogenesis" Cytosol Nucleoplasm "HPA008026: AB_1857603" "unprognostic (3.32e-1)" "unprognostic (3.00e-1)" "unprognostic (6.47e-2)" "unprognostic (4.55e-1)" "unprognostic (1.38e-1)" "unprognostic (4.43e-2)" "unprognostic (2.69e-3)" "unprognostic (6.09e-2)" "unprognostic (2.09e-1)" "unprognostic (5.96e-2)" "prognostic favorable (5.59e-4)" "unprognostic (1.19e-1)" "unprognostic (2.75e-2)" "unprognostic (7.06e-2)" "unprognostic (2.64e-1)" "unprognostic (1.07e-2)" "unprognostic (2.51e-2)" 33.3 15.5 17.4 23.1 17.0 15.2 24.6 16.6 19.9 24.3 14.1 44.8 13.5 23.6 8.1 43.8 24.7 20.4 42.7 17.5 17.6 33.5 45.3 36.4 24.3 24.8 19.0 40.3 45.7 21.8 30.1 13.5 20.6 28.5 12.7 7.5 32.0 23.1 125.2 38.8 23.7 20.0 19.9 35.4 35.5 52.5 20.1 15.6 25.3 39.6 21.4 41.7 26.7 19.8 17.4 7.4 36.6 38.3 25.3 14.7 20.5 17.2 23.1 20.3 21.8 41.3 24.2 73.0 13.8 16.1 21.5 17.1 33.5 7.4 14.9 32.0 26.4 47.7 7.5 53.3 25.1 28.1 60.9 13.3 27.7 15.6 8.2 10.9 12.9 55.2 59.7 25.7 12.9 27.0 29.3 37.1 23.5 31.2 10.2 33.3 24.9 49.1 12.7 19.2 44.6 22.7 13.2 20.5 58.5 23.1 13.9 32.7 21.6 12.7 26.5 37.7 38.3 26.6 16.2 61.3 66.3 24.3 42.8 1.2 3.8 6.8 3.1 8.6 3.6 2.8 2.1 2.2 3.5 2.9 1.2 1.8 25.2 2.1 12.0 3.3 1.3 3.5 17.4 17.0 16.6 19.9 17.5 17.6 24.8 19.0 20.6 19.9 20.1 19.8 10.7 12.8 15.3 11.8 22.0 61.3 54.0 9.4 16.5 11.8 28.3 15.4 25.3 8.6 11.1 11.0 4.2 6.5 15.8 34.8 17.6 21.2 116.7 23.9 11.2 15.2 23.4 7.8 24.8 31.6 10.7 19.2 33.1 36.5 13.3 4.9 14.3 23.7 24.7 10.1 17.3 15.5 12.2 23.3 69.5 236.8 23.0 32.2 30.2 21.5 19.2 4.9 18.6 7.5 12.3 28.5 16.3 33.4 17.0 57.1 6.2 14.9 25.6 10.5 26.3 20.6 18.6 14.9 11.1 28.7 75.4 57.2 17.3 17.6 15.1 51.3 STT3A "ITM1, MGC9042, STT3-A, TMC" ENSG00000134910 "STT3 oligosaccharyltransferase complex catalytic subunit A" P46977 11 125591712-125625215 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Glycosyltransferase, Transferase" "Cancer-related genes, Congenital disorder of glycosylation, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "parathyroid gland: 391.8" "Cell type enhanced" "Detected in all" "Plasma cells: 91.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA030735 Approved NA NA 23000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 1: K-562 - Erythropoiesis" "Cluster 55: Plasma cells - Humoral immune response" "HPA030735: AB_10603342" "unprognostic (8.25e-3)" "unprognostic (5.45e-2)" "unprognostic (3.02e-2)" "prognostic favorable (1.32e-4)" "unprognostic (5.10e-2)" "unprognostic (1.72e-2)" "prognostic unfavorable (3.57e-4)" "unprognostic (8.40e-2)" "unprognostic (4.80e-2)" "unprognostic (1.16e-2)" "unprognostic (8.96e-3)" "unprognostic (1.31e-1)" "prognostic unfavorable (4.96e-4)" "unprognostic (2.60e-2)" "unprognostic (6.38e-2)" "unprognostic (1.28e-1)" "unprognostic (1.82e-2)" 38.5 39.2 14.6 44.6 17.7 31.8 55.8 17.9 16.9 84.9 29.8 54.0 42.2 60.8 140.4 30.2 56.3 39.5 38.5 15.0 20.1 45.8 69.0 39.0 32.9 19.4 18.4 68.0 69.0 391.8 29.0 63.8 19.6 56.2 59.5 40.0 80.1 77.2 18.4 31.6 42.1 58.9 17.5 34.4 51.4 44.5 17.5 34.8 83.9 24.4 48.8 50.4 33.3 23.1 113.1 99.5 123.7 173.6 230.1 176.4 133.8 198.5 238.5 158.6 196.6 304.2 294.3 143.6 236.2 297.3 222.4 202.7 173.5 176.2 208.5 114.8 90.0 341.0 63.7 215.1 254.4 208.4 153.6 138.4 125.8 219.5 424.5 186.1 182.2 63.9 147.1 210.6 205.4 82.7 84.4 65.6 78.6 221.8 106.0 98.9 107.1 221.5 173.7 170.1 77.5 66.2 142.9 229.3 72.5 144.9 267.8 148.1 164.5 227.7 82.0 97.6 159.7 66.3 82.4 109.6 87.4 206.3 184.7 96.2 46.7 36.6 56.1 45.4 77.9 42.8 53.7 52.0 65.2 32.1 37.1 44.4 15.7 52.8 41.8 158.3 44.0 47.5 14.6 17.7 17.9 16.9 15.0 20.1 19.4 18.4 19.6 17.5 17.5 23.1 17.4 28.9 25.0 6.8 20.8 16.2 14.3 40.3 12.5 11.6 15.2 9.8 23.3 27.1 29.1 16.5 20.9 45.4 21.7 16.1 1.9 30.1 10.6 22.9 51.0 17.3 15.6 19.6 7.6 27.2 73.4 33.0 26.0 57.0 17.1 29.0 32.2 38.5 30.7 1.7 8.9 37.3 20.3 23.6 31.9 5.4 21.5 17.3 24.9 9.4 12.6 13.2 11.3 11.6 10.9 28.6 12.2 18.8 91.9 19.3 15.6 13.6 23.6 15.1 19.7 23.1 32.8 33.5 13.1 21.9 14.8 45.6 14.6 22.3 26.9 13.9 STT3B "FLJ90106, SIMP, STT3-B" ENSG00000163527 "STT3 oligosaccharyltransferase complex catalytic subunit B" Q8TCJ2 3 31532638-31637616 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Glycosyltransferase, Transferase" "Congenital disorder of glycosylation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 264.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036448, HPA036646" Approved Supported "Endoplasmic reticulum" NA NA 17000 "Cluster 15: NK-cells - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 25: Spermatids - Spermatogenesis" "Endoplasmic reticulum" "HPA036448: AB_2675129, HPA036646: AB_10673472" "unprognostic (2.17e-2)" "unprognostic (2.23e-1)" "prognostic favorable (7.91e-5)" "unprognostic (1.60e-1)" "unprognostic (3.11e-1)" "unprognostic (2.74e-2)" "unprognostic (2.02e-2)" "unprognostic (1.44e-1)" "unprognostic (1.04e-1)" "unprognostic (2.60e-1)" "unprognostic (3.26e-3)" "unprognostic (3.68e-2)" "unprognostic (3.86e-2)" "unprognostic (9.18e-2)" "unprognostic (1.42e-1)" "unprognostic (6.71e-3)" "unprognostic (1.02e-1)" 42.8 59.9 21.1 52.2 29.5 63.7 57.1 23.3 27.0 62.1 30.9 59.7 47.9 51.8 90.3 44.8 45.3 60.2 49.4 22.6 30.7 49.6 74.8 49.3 59.9 24.3 23.1 105.5 45.7 76.6 24.8 60.3 23.9 56.3 61.4 38.6 49.9 51.3 62.1 44.7 49.1 57.7 25.4 44.2 55.1 94.3 26.1 71.8 80.7 57.8 58.8 56.6 32.1 27.6 77.9 128.0 115.4 121.7 142.0 142.3 249.7 142.3 124.9 104.2 119.9 117.7 164.5 134.0 67.8 130.0 85.8 63.9 108.1 123.5 135.9 377.1 70.2 115.0 120.7 126.4 109.4 252.0 131.1 109.8 129.7 148.8 186.7 160.7 107.1 168.3 62.8 209.6 144.0 44.4 246.8 154.8 92.9 129.6 70.7 252.3 62.6 196.0 122.0 110.7 48.7 59.4 141.3 207.2 84.5 98.3 93.4 132.8 209.3 139.8 88.6 139.7 127.3 129.0 166.4 111.4 126.9 170.0 117.6 2.1 3.3 6.2 3.1 3.9 5.0 2.4 5.6 4.4 2.9 2.7 5.3 4.3 1.2 6.1 2.9 5.5 3.0 2.0 21.1 29.5 23.3 27.0 22.6 30.7 24.3 23.1 23.9 25.4 26.1 27.6 32.1 86.6 57.7 34.6 69.6 68.1 58.4 34.1 74.6 51.0 57.2 29.5 71.1 54.3 76.0 44.1 68.8 67.3 65.3 41.8 13.7 34.1 162.8 25.0 65.9 42.0 45.1 50.9 61.5 45.3 100.5 49.6 45.3 43.5 31.1 43.6 37.9 68.2 54.8 45.4 59.4 57.5 36.7 58.0 76.0 264.9 36.4 71.5 51.6 53.4 49.1 34.2 56.7 60.3 73.3 36.5 50.0 32.7 144.2 74.1 50.5 31.5 42.2 37.4 26.3 39.0 53.3 90.9 55.2 65.0 61.8 95.4 78.3 68.4 66.1 69.4 STUB1 "CHIP, HSPABP2, NY-CO-7, SDCCAG7, UBOX1" ENSG00000103266 "STIP1 homology and U-box containing protein 1" Q9UNE7 16 680224-682870 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB037202, CAB037209, HPA041222, HPA043531" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Mitochondria" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Basic cellular processes" "Nucleoplasm, Cytosol" "CAB037202: AB_1840759, CAB037209: AB_1840757, HPA041222: AB_2677368, HPA043531: AB_2678533" "unprognostic (5.70e-2)" "unprognostic (2.53e-1)" "unprognostic (1.90e-1)" "unprognostic (3.89e-1)" "unprognostic (9.00e-2)" "unprognostic (3.06e-1)" "unprognostic (4.09e-3)" "unprognostic (2.21e-1)" "unprognostic (2.23e-1)" "unprognostic (8.31e-2)" "unprognostic (5.78e-2)" "unprognostic (6.77e-2)" "prognostic favorable (6.49e-9)" "unprognostic (9.67e-2)" "unprognostic (3.57e-1)" "unprognostic (1.55e-1)" "unprognostic (1.30e-1)" 80.2 126.3 185.5 35.6 186.9 48.9 76.0 183.8 242.7 74.8 173.1 100.3 50.7 67.0 60.3 86.8 65.3 42.1 151.1 187.3 185.3 91.4 100.7 65.0 52.5 188.2 184.2 65.7 93.7 90.6 93.7 23.9 187.9 80.2 32.6 33.2 86.6 53.5 201.8 111.7 63.1 40.1 180.6 70.0 86.2 45.1 193.5 42.3 72.9 125.2 38.2 80.7 69.1 188.0 81.6 107.6 59.4 108.0 123.4 102.5 43.8 112.8 95.1 100.9 90.5 131.0 97.1 83.0 78.2 147.5 69.1 69.7 73.0 137.3 42.9 93.6 318.8 53.4 154.1 104.7 183.7 85.9 96.4 141.1 134.3 118.2 71.4 76.3 106.2 72.3 87.1 119.2 149.3 318.4 90.1 85.4 76.4 107.1 127.5 143.5 46.8 200.6 132.5 72.6 121.1 103.4 89.4 165.8 137.1 35.9 114.1 147.8 108.7 104.3 99.8 94.3 125.9 137.6 150.2 132.3 83.8 73.9 122.0 17.7 13.6 21.7 15.7 12.9 14.5 19.6 13.5 13.8 12.1 21.0 12.8 11.6 13.4 11.2 13.9 20.7 13.2 7.2 185.5 186.9 183.8 242.7 187.3 185.3 188.2 184.2 187.9 180.6 193.5 188.0 96.2 38.5 27.9 24.5 88.9 114.7 107.2 63.9 83.1 93.3 137.1 158.7 1.0 104.4 52.4 130.6 52.1 80.1 101.4 142.7 285.7 139.6 8.6 82.8 69.6 71.6 76.0 68.5 23.2 169.7 93.8 85.7 68.3 65.0 21.0 97.9 80.3 122.1 113.1 84.1 21.1 101.4 85.5 69.4 94.9 16.7 109.0 79.0 117.4 15.0 154.4 184.3 110.2 14.1 24.8 190.2 110.8 112.1 108.6 160.8 165.5 324.1 61.2 83.9 72.3 82.3 129.7 50.4 62.4 107.0 120.5 100.7 96.2 132.5 109.3 118.8 STYK1 "DKFZp761P1010, NOK, SuRTK106" ENSG00000060140 "Serine/threonine/tyrosine kinase 1" Q6J9G0 12 10618923-10674318 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Transferase, Tyrosine-protein kinase" Proto-oncogene "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 17.1;stomach 1: 17.5" "Cell type enhanced" "Detected in many" "Distal enterocytes: 19.6;Excitatory neurons: 20.6;Gastric mucus-secreting cells: 15.3;Paneth cells: 12.6;Proximal enterocytes: 10.6" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in many" "cerebral cortex: 5.2" "Immune cell enriched" "Detected in some" 7 "NK-cell: 12.5" "Lineage enriched" "Detected in many" 7 "NK-cells: 12.5" "Cell line enhanced" "Detected in many" "CAPAN-2: 28.7;HDLM-2: 17.5;HMC-1: 18.3;HUVEC TERT2: 25.5;TIME: 23.8" "Region enhanced" "Detected in single" "basal ganglia: 2.3" "Not detected" "Not detected" "HPA040468, HPA048569" Enhanced Approved "Nucleoplasm,Plasma membrane" NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 27: Mucus-secreting cells - Mucin production" "Plasma membrane" Nucleoplasm "HPA040468: AB_2676998, HPA048569: AB_2680446" "unprognostic (2.30e-1)" "unprognostic (2.22e-1)" "unprognostic (1.21e-1)" "unprognostic (1.75e-1)" "unprognostic (3.11e-2)" "unprognostic (3.35e-2)" "unprognostic (6.85e-2)" "unprognostic (5.08e-3)" "unprognostic (3.37e-1)" "unprognostic (3.50e-1)" "unprognostic (2.21e-3)" "unprognostic (1.02e-1)" "unprognostic (1.70e-14)" "unprognostic (5.18e-3)" "unprognostic (1.22e-1)" "unprognostic (2.33e-1)" "unprognostic (1.45e-2)" 0.4 0.3 1.2 1.8 3.0 1.1 3.9 0.0 5.2 1.9 0.0 15.9 2.4 0.5 1.2 7.3 2.2 3.5 0.1 3.6 0.0 0.6 0.3 1.3 1.4 0.0 0.0 0.3 0.3 0.0 2.4 0.7 0.0 11.6 17.1 0.9 6.7 0.9 0.1 2.8 11.2 0.6 0.0 0.9 17.5 0.2 0.0 0.2 0.4 0.0 2.5 5.1 3.3 0.3 4.8 0.2 0.0 0.6 0.0 0.0 1.3 7.3 0.7 3.5 3.4 2.6 28.7 0.3 4.7 1.8 4.5 1.4 1.6 8.0 7.4 17.5 0.4 1.0 2.4 0.2 0.0 2.2 18.3 0.4 0.4 5.1 0.3 0.5 25.5 0.2 0.3 0.3 8.1 3.1 0.2 1.3 4.2 11.8 2.0 0.1 2.0 0.3 2.5 14.6 0.9 0.1 4.5 4.9 0.0 6.7 3.5 0.6 23.8 1.0 3.8 0.5 0.8 0.0 1.0 0.2 3.5 0.2 5.5 0.0 0.0 0.0 1.7 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 1.0 0.1 12.5 0.0 0.0 0.0 0.3 1.2 3.0 0.0 5.2 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.0 2.2 0.0 0.0 0.3 0.8 3.1 1.2 0.6 3.3 2.0 0.7 1.5 3.3 0.0 0.0 0.1 1.8 19.6 0.0 0.5 0.2 7.3 0.5 0.4 4.2 0.8 20.6 0.2 0.6 0.2 15.3 4.5 1.3 6.3 0.0 0.0 0.0 0.0 1.6 8.9 2.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.1 0.0 6.2 0.0 0.5 5.9 12.6 0.0 0.9 4.7 10.6 0.0 8.8 0.4 0.0 1.2 0.2 0.2 0.8 3.1 1.0 0.3 1.9 0.0 6.9 5.5 SUGCT "C7orf10, DERP13, FLJ11808, ORF19" ENSG00000175600 "Succinyl-CoA:glutarate-CoA transferase" Q9HAC7 7 40135005-40860763 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" Transferase "Disease variant, Glutaricaciduria" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "kidney: 44.4;liver: 28.4" "Cell type enhanced" "Detected in many" "Astrocytes: 76.0;Inhibitory neurons: 38.5;Oligodendrocyte precursor cells: 58.3;Proximal tubular cells: 81.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "naive CD4 T-cell: 1.4" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "HBEC3-KT: 43.9;LHCN-M2: 26.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026698, HPA026704, HPA026705" Enhanced NA NA "Cluster 32: T-cells - Unknown function" "Cluster 81: Kidney & Liver - Metabolism" "Cluster 30: Epithelial cell lines - Translation" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA026698: AB_10600191, HPA026704: AB_10600230, HPA026705: AB_10601003" "unprognostic (4.66e-3)" "unprognostic (3.45e-2)" "unprognostic (2.06e-2)" "unprognostic (3.32e-3)" "unprognostic (5.26e-2)" "unprognostic (1.06e-1)" "unprognostic (1.14e-3)" "unprognostic (1.75e-2)" "unprognostic (2.61e-1)" "unprognostic (1.80e-1)" "unprognostic (5.27e-3)" "unprognostic (7.65e-2)" "prognostic favorable (3.93e-7)" "unprognostic (2.62e-2)" "unprognostic (3.38e-1)" "unprognostic (3.41e-3)" "prognostic unfavorable (2.53e-4)" 2.4 9.0 1.7 0.9 1.8 0.1 2.3 1.7 2.2 2.2 4.4 4.5 0.7 2.2 1.0 2.1 1.7 2.8 3.9 1.7 2.0 44.4 28.4 0.6 0.8 2.0 2.1 4.1 2.3 4.1 0.9 0.6 1.9 2.0 2.4 2.0 1.4 1.8 10.3 0.9 5.3 2.2 1.8 0.8 1.0 2.8 1.8 0.8 1.8 8.2 1.0 2.0 1.6 1.8 0.8 0.1 4.8 3.4 5.0 11.5 1.8 2.5 4.6 3.2 3.8 2.0 1.0 3.1 1.2 3.5 3.4 0.2 1.4 43.9 5.3 0.0 2.1 2.8 0.3 7.3 6.2 0.4 0.3 14.6 9.7 3.7 2.2 6.9 0.9 1.2 3.9 0.3 26.2 0.0 0.1 0.4 8.1 0.1 3.7 2.9 0.4 0.0 7.4 0.0 0.3 2.7 4.0 1.8 5.8 7.9 0.1 0.7 3.7 14.6 4.2 0.2 1.0 0.3 0.0 0.2 2.8 1.2 3.3 0.0 0.0 0.1 0.2 0.0 0.4 0.5 0.7 0.3 0.0 0.3 1.4 0.9 0.3 0.0 0.0 0.0 0.0 0.2 1.7 1.8 1.7 2.2 1.7 2.0 2.0 2.1 1.9 1.8 1.8 1.8 0.6 3.2 0.5 76.0 1.9 2.0 2.1 26.0 10.2 1.0 1.3 23.0 5.1 1.5 4.4 1.8 8.4 1.5 0.0 10.1 17.6 1.2 31.0 0.9 2.5 0.7 3.6 0.4 19.8 0.8 2.4 3.5 0.0 1.3 0.0 2.2 0.0 21.1 0.3 0.0 38.5 1.5 0.0 1.3 1.0 16.7 6.2 0.7 3.6 14.0 0.1 5.3 0.0 58.3 22.8 0.6 5.6 3.0 0.1 0.8 13.9 81.6 0.8 4.5 6.6 1.4 15.3 2.7 3.1 3.2 0.6 0.8 0.7 7.4 5.3 0.7 SULT1A1 "P-PST, STP, STP1" ENSG00000196502 "Sulfotransferase family 1A member 1" P50225 16 28603944-28623625 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Catecholamine metabolism, Lipid metabolism, Steroid metabolism" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 135.0;liver: 248.9" "Cell type enhanced" "Detected in many" "Distal enterocytes: 321.6;Hepatocytes: 229.6;Kupffer cells: 214.1;Paneth cells: 309.3;Proximal enterocytes: 926.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 6 "classical monocyte: 257.6;intermediate monocyte: 212.2;myeloid DC: 116.3;neutrophil: 246.7;non-classical monocyte: 122.6" "Group enriched" "Detected in all" 33 "dendritic cells: 116.3;granulocytes: 246.7;monocytes: 257.6" "Group enriched" "Detected in many" 4 "EFO-21: 171.0;Hep G2: 353.6" "HPA049500, HPA051051" Supported NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 45: Enterocytes - Digestion" "HPA049500: AB_2680796, HPA051051: AB_2681327" "unprognostic (2.57e-2)" "unprognostic (2.80e-2)" "unprognostic (8.40e-2)" "unprognostic (1.30e-1)" "unprognostic (5.60e-3)" "unprognostic (7.63e-2)" "unprognostic (4.17e-2)" "prognostic favorable (7.02e-4)" "unprognostic (1.30e-1)" "unprognostic (2.40e-1)" "unprognostic (6.71e-2)" "unprognostic (2.07e-1)" "unprognostic (3.70e-3)" "unprognostic (1.49e-1)" "unprognostic (4.10e-2)" "unprognostic (7.39e-2)" "unprognostic (1.89e-2)" 30.5 100.1 21.0 10.6 21.5 23.7 15.3 21.2 23.5 8.8 31.0 54.0 135.0 7.2 32.3 5.1 14.2 10.9 26.5 22.5 22.7 30.8 248.9 46.6 15.2 22.8 21.7 7.3 17.8 23.4 24.2 12.4 21.8 8.9 41.7 6.0 26.2 20.3 11.3 3.0 104.3 11.1 21.4 66.2 22.2 13.8 22.2 7.6 35.3 4.8 4.2 13.6 5.1 21.7 6.6 1.5 2.7 10.9 0.0 0.0 23.2 0.0 0.2 0.1 0.0 0.9 42.2 0.3 171.0 0.2 1.6 0.4 3.1 12.1 0.3 0.7 30.8 7.2 13.1 353.6 18.3 0.0 12.6 1.1 0.9 0.0 0.0 0.2 2.9 11.9 4.4 4.2 3.0 39.9 0.7 11.0 2.5 1.8 0.1 11.6 1.3 20.5 2.9 2.9 6.9 0.4 0.4 55.7 1.1 14.1 32.8 32.2 22.5 0.5 7.8 0.4 0.0 5.8 5.5 1.6 2.7 63.1 0.0 32.4 257.6 5.0 1.4 212.2 1.2 1.2 1.9 1.4 116.3 0.3 2.9 1.4 246.7 4.3 122.6 8.6 6.3 129.1 21.0 21.5 21.2 23.5 22.5 22.7 22.8 21.7 21.8 21.4 22.2 21.7 7.1 192.3 97.0 25.1 4.6 1.1 8.0 13.2 9.6 21.8 14.4 9.9 14.2 80.1 17.8 16.5 10.4 2.4 3.0 321.6 129.1 13.4 107.8 18.2 5.9 17.0 19.9 20.2 34.4 19.9 1.4 29.2 23.0 5.2 49.9 15.9 43.9 229.6 38.5 8.4 27.5 63.9 14.2 214.1 8.9 34.4 51.3 45.3 1.8 5.6 37.8 67.8 3.1 18.1 3.6 6.2 309.3 34.6 3.6 3.9 926.9 80.9 40.2 3.8 19.7 11.2 15.2 22.8 5.8 9.6 0.3 1.9 9.0 13.1 79.2 6.8 SULT1A2 "HAST4, STP2" ENSG00000197165 "Sulfotransferase family 1A member 2" P50226 16 28591943-28597050 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Catecholamine metabolism, Lipid metabolism, Steroid metabolism" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 7 "intestine: 48.2;liver: 50.1" "Group enriched" "Detected in many" 4 "Distal enterocytes: 204.8;Paneth cells: 146.1;Proximal enterocytes: 505.6" "Cancer enhanced" "Detected in many" "liver cancer: 6.8" "Low region specificity" "Detected in many" "Group enriched" "Detected in many" 7 "classical monocyte: 9.1;intermediate monocyte: 7.7;myeloid DC: 3.3;neutrophil: 12.4;non-classical monocyte: 3.9" "Group enriched" "Detected in many" 24 "dendritic cells: 3.3;granulocytes: 12.4;monocytes: 9.1" "Cell line enriched" "Detected in many" 4 "Hep G2: 50.2" "HPA049500, HPA051051" Supported NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 45: Enterocytes - Digestion" "HPA049500: AB_2680796, HPA051051: AB_2681327" "unprognostic (4.15e-2)" "unprognostic (9.88e-2)" "unprognostic (1.53e-1)" "unprognostic (6.13e-2)" "unprognostic (5.35e-2)" "unprognostic (1.43e-1)" "unprognostic (1.05e-1)" "unprognostic (2.41e-2)" "unprognostic (1.05e-1)" "unprognostic (2.49e-4)" "unprognostic (5.83e-2)" "unprognostic (2.81e-1)" "unprognostic (1.02e-1)" "unprognostic (2.74e-1)" "unprognostic (2.98e-1)" "unprognostic (1.44e-1)" "unprognostic (8.52e-3)" 2.0 2.9 1.2 0.7 1.0 1.2 1.1 2.2 1.4 0.2 0.6 13.6 48.2 0.4 1.3 0.3 1.0 1.0 2.7 1.2 0.6 3.2 50.1 6.9 0.9 0.8 0.6 0.7 2.1 2.9 1.9 1.7 0.9 0.5 13.0 0.7 1.5 1.0 0.9 0.7 45.4 0.7 0.4 4.3 1.1 0.7 0.8 0.4 7.2 0.2 0.6 2.1 0.2 0.7 1.9 1.1 1.0 0.7 0.3 0.4 9.7 1.0 0.0 0.1 0.1 2.0 5.1 0.3 12.2 0.3 0.1 2.9 0.5 0.6 0.2 1.0 0.5 1.5 2.4 50.2 0.7 1.0 1.9 0.3 0.7 0.8 0.2 0.6 0.3 0.8 1.0 2.3 0.4 1.8 0.3 2.6 1.4 0.3 0.3 1.6 0.3 1.0 0.2 1.5 0.6 1.4 0.3 3.9 0.1 1.6 3.2 0.7 0.6 2.5 1.4 1.9 0.8 2.2 1.6 0.4 0.6 0.7 0.8 1.0 9.1 0.1 0.1 7.7 0.0 0.1 0.1 0.1 3.3 0.1 0.1 0.2 12.4 0.2 3.9 0.8 0.3 4.6 1.2 1.0 2.2 1.4 1.2 0.6 0.8 0.6 0.9 0.4 0.8 0.7 0.6 28.9 15.1 2.0 0.5 0.3 0.4 1.9 0.0 0.3 1.9 3.7 2.4 5.7 7.1 3.7 0.0 0.1 0.1 204.8 15.6 7.8 0.2 2.5 0.5 3.8 3.0 0.0 2.8 4.5 0.2 5.4 4.1 0.8 11.4 1.2 7.5 69.5 1.6 0.0 1.8 20.9 0.0 7.6 0.4 1.4 1.5 1.1 0.0 1.0 1.2 4.4 0.0 1.5 0.6 4.2 146.1 1.5 0.1 0.3 505.6 38.2 2.9 0.5 0.0 0.4 0.8 0.7 0.3 0.1 0.1 0.3 0.5 1.6 14.3 0.9 SULT1A3 "STM, TL-PST" ENSG00000261052 "Sulfotransferase family 1A member 3" P0DMM9 16 30199228-30204310 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Catecholamine metabolism, Lipid metabolism, Steroid metabolism" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 237.2" "Cell type enriched" "Detected in many" 4 "Proximal enterocytes: 129.1" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 10 "classical monocyte: 61.3;intermediate monocyte: 53.2;myeloid DC: 33.7;non-classical monocyte: 25.0" "Group enriched" "Detected in all" 11 "dendritic cells: 33.7;monocytes: 61.3" "Cell line enhanced" "Detected in all" "CAPAN-2: 166.9;Hep G2: 303.6;Karpas-707: 239.4" "HPA049500, HPA051051" Supported NA NA 160000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 45: Intestine - Brush border" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 45: Enterocytes - Digestion" "HPA049500: AB_2680796, HPA051051: AB_2681327" "unprognostic (2.61e-1)" "unprognostic (1.72e-3)" "unprognostic (1.98e-3)" "unprognostic (4.98e-2)" "unprognostic (1.34e-1)" "unprognostic (1.18e-1)" "unprognostic (7.27e-2)" "unprognostic (2.09e-2)" "unprognostic (2.99e-2)" "unprognostic (2.31e-2)" "unprognostic (2.12e-1)" "unprognostic (1.04e-1)" "unprognostic (9.18e-8)" "unprognostic (2.34e-2)" "unprognostic (2.51e-1)" "unprognostic (1.66e-1)" "unprognostic (9.48e-5)" 15.7 13.7 53.3 21.9 54.0 36.8 15.7 56.3 72.9 15.4 54.3 57.3 237.2 16.8 18.0 14.3 18.0 14.8 11.0 54.0 53.9 34.6 34.5 26.6 30.3 53.8 53.0 10.8 15.9 17.5 23.8 22.4 54.3 20.1 46.4 23.2 25.8 17.8 11.0 25.7 146.6 24.5 52.0 31.8 22.2 9.6 54.3 16.3 20.2 18.9 29.3 13.5 10.5 55.9 32.6 48.8 30.6 21.3 28.4 19.8 46.0 15.8 16.9 16.7 18.9 21.1 166.9 16.9 150.0 16.0 10.9 45.5 38.8 14.0 16.7 19.9 30.6 93.2 61.2 303.6 11.1 14.2 34.9 21.9 20.9 25.4 5.9 34.2 30.6 21.9 19.0 239.4 12.0 55.4 9.6 62.3 19.1 76.2 20.9 38.6 14.8 32.2 29.4 22.0 15.3 24.7 4.8 43.0 7.8 11.4 23.8 22.1 38.3 34.0 17.4 29.4 11.7 28.8 78.1 8.7 17.4 31.7 20.5 1.9 61.3 0.3 4.3 53.2 0.9 3.4 1.1 1.5 33.7 1.7 0.8 0.7 1.6 1.4 25.0 0.5 0.9 20.4 53.3 54.0 56.3 72.9 54.0 53.9 53.8 53.0 54.3 52.0 54.3 55.9 3.3 12.8 12.0 0.0 4.2 2.0 2.2 1.2 0.6 5.3 2.4 1.3 1.8 4.3 7.6 0.0 8.4 5.3 2.8 13.9 0.0 3.3 1.3 0.9 0.9 5.8 1.2 6.1 0.0 4.0 2.3 4.4 2.6 1.3 1.3 1.7 3.9 2.8 1.5 1.7 0.0 13.4 2.0 5.0 3.7 0.5 0.9 2.6 1.8 0.0 4.9 2.6 4.1 0.0 0.0 6.3 25.3 1.9 1.4 4.3 129.1 0.5 2.3 6.7 0.0 1.7 1.7 0.8 0.3 0.9 2.7 3.0 3.8 1.2 26.8 2.1 SULT1A4 ENSG00000213648 "Sulfotransferase family 1A member 4" P0DMN0 16 29459913-29464966 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Catecholamine metabolism, Lipid metabolism, Steroid metabolism" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 61.8" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 6.4;Alveolar cells type 2: 2.0;Club cells: 3.7;Distal enterocytes: 1.6;Proximal enterocytes: 3.5" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "intermediate monocyte: 23.1;myeloid DC: 17.2" "Group enriched" "Detected in many" 12 "dendritic cells: 17.2;monocytes: 23.1" "Cell line enhanced" "Detected in many" "CAPAN-2: 69.2;Hep G2: 156.6;SK-BR-3: 32.4" "HPA049500, HPA051051" Supported NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 14: B-cells - Humoral immune response" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 11: Alveolar cells - Smell perception" "HPA049500: AB_2680796, HPA051051: AB_2681327" "unprognostic (4.14e-2)" "unprognostic (1.04e-1)" 31.7 4.8 1.7 7.3 2.0 3.2 25.0 1.8 4.3 9.0 0.8 46.0 29.0 7.6 0.7 5.7 11.6 3.4 19.8 2.0 1.1 7.8 7.0 21.0 1.6 2.6 1.4 3.7 3.9 2.0 3.8 2.4 2.1 4.4 7.5 0.7 14.6 3.4 6.3 9.1 61.8 1.9 1.1 34.8 15.5 2.3 2.2 1.2 10.4 0.6 2.6 12.8 9.2 2.4 0.6 0.6 6.7 1.3 0.5 1.2 1.5 3.6 0.2 1.0 0.5 2.5 69.2 0.2 22.2 1.2 2.9 13.3 1.4 0.9 0.6 1.5 2.7 0.9 3.0 156.6 1.6 0.0 5.6 0.4 0.0 1.4 0.6 4.0 4.0 0.5 2.9 4.1 0.4 3.0 1.1 19.3 3.2 2.8 1.1 4.2 0.6 1.5 3.9 4.0 0.8 0.8 0.0 32.4 0.1 0.6 0.6 0.3 1.0 3.0 0.5 0.5 1.2 7.5 9.6 3.2 2.3 2.3 0.3 1.6 7.0 0.0 0.8 23.1 0.1 0.7 0.1 0.1 17.2 0.0 0.4 0.0 0.4 0.1 5.3 0.1 0.1 5.1 1.7 2.0 1.8 4.3 2.0 1.1 2.6 1.4 2.1 1.1 2.2 2.4 0.2 6.4 2.0 0.0 0.1 0.3 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.0 3.7 0.0 0.0 0.3 0.1 1.6 0.0 0.1 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.9 0.1 0.7 0.0 0.0 0.0 0.0 0.0 0.4 0.2 0.0 0.0 0.2 0.0 0.6 0.0 0.0 0.0 0.5 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.6 0.3 0.0 0.0 0.1 3.5 0.0 0.7 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.2 0.0 1.0 0.0 SULT1C3 ENSG00000196228 "Sulfotransferase family 1C member 3" Q6IMI6 2 108239971-108265351 "Enzymes, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 83 "breast: 368.4" "Not detected" "Not detected" "Cancer enriched" "Detected in some" 4 "breast cancer: 2.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enhanced" "Detected in all" "spinal cord: 36.7" HPA060368 Approved Cytosol NA NA "Cluster 5: Breast - Unknown function" "Cluster 27: Mucus-secreting cells - Mucin production" Cytosol "HPA060368: " "unprognostic (1.14e-3)" "unprognostic (1.78e-1)" "unprognostic (4.13e-1)" "unprognostic (6.64e-2)" 0.1 0.0 0.1 0.0 0.1 0.0 368.4 0.0 0.1 0.1 1.6 0.4 3.5 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.9 0.0 0.0 0.0 0.0 0.5 4.4 0.0 0.0 0.0 1.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.1 0.1 0.1 0.2 0.1 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 SULT1E1 "EST, STE" ENSG00000109193 "Sulfotransferase family 1E member 1" P49888 4 69841212-69860145 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 27.5;liver: 37.2;skin 1: 19.3;vagina: 30.4" "Cell type enhanced" "Detected in some" "Endometrial ciliated cells: 65.8;Glandular and luminal cells: 35.1;Hepatocytes: 51.4;Paneth cells: 66.3;Proximal enterocytes: 21.5" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 16 "HHSteC: 71.1;HSkMC: 32.3;hTCEpi: 27.3;HUVEC TERT2: 20.4" "Not detected" "Not detected" "Region enhanced" "Detected in some" "cerebral cortex: 7.8" "HPA028213, HPA028728, CAB047344" Enhanced Uncertain "Nuclear membrane,Cytosol" NA NA "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 30: Epithelial cell lines - Translation" "Cluster 44: Endometrium - Transcription" "Nuclear membrane, Cytosol" "CAB047344: , HPA028213: AB_10599848, HPA028728: AB_10601894" "unprognostic (5.60e-2)" "prognostic favorable (4.06e-4)" "unprognostic (2.48e-1)" "unprognostic (1.07e-3)" "unprognostic (2.42e-1)" "unprognostic (1.95e-1)" "unprognostic (1.70e-1)" "unprognostic (1.72e-1)" "unprognostic (1.41e-1)" "unprognostic (2.89e-1)" "unprognostic (3.22e-3)" "unprognostic (8.62e-2)" "unprognostic (6.48e-5)" "unprognostic (2.48e-1)" "unprognostic (4.11e-2)" "unprognostic (5.55e-2)" 0.1 14.5 0.1 0.0 0.1 0.1 0.1 0.1 0.2 13.5 4.1 0.2 27.5 0.3 1.0 0.8 0.2 0.2 0.0 0.1 0.0 0.3 37.2 2.3 0.0 0.1 0.1 0.0 0.2 0.0 0.6 0.1 0.1 0.7 0.1 0.0 6.6 0.4 0.0 19.3 27.3 0.1 0.0 0.0 2.1 0.1 0.1 0.5 0.0 0.0 1.5 0.7 30.4 0.2 0.0 0.0 0.0 0.0 0.6 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 71.1 0.0 0.0 32.3 27.3 0.0 0.9 0.0 20.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.2 0.1 0.0 0.1 0.1 0.1 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 11.9 1.0 8.7 0.0 0.0 0.1 0.0 0.1 1.5 2.8 1.8 0.0 0.2 0.0 0.2 0.0 0.0 0.0 65.8 1.3 0.3 0.0 0.0 0.1 1.3 0.1 0.2 0.0 35.1 0.0 0.0 2.5 51.4 0.3 0.0 0.0 4.7 0.0 0.8 0.7 0.0 0.3 0.2 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.6 66.3 0.0 0.0 0.0 21.5 0.0 0.3 0.0 0.0 0.0 0.5 0.0 0.1 0.0 3.4 1.5 0.1 0.0 13.8 0.2 SULT2A1 "DHEA-ST, STD" ENSG00000105398 "Sulfotransferase family 2A member 1" Q06520 19 47870467-47886315 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Bile acid catabolism, Lipid degradation, Lipid metabolism, Steroid metabolism" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "liver: 1072.1" "Cell type enriched" "Detected in some" 9 "Hepatocytes: 1578.7" "Cancer enriched" "Detected in some" 52 "liver cancer: 244.3" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "basophil: 2.9" "Lineage enriched" "Detected in single" 6 "granulocytes: 2.9" "Group enriched" "Detected in some" 34 "Hep G2: 39.6;RT4: 26.7" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB018755, HPA041487, HPA063633" Enhanced Supported Cytosol NA NA 1200000 "Cluster 11: Basophils - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 2: Hepatocytes - Metabolism" Cytosol "CAB018755: AB_650242, HPA041487: AB_2677507, HPA063633: AB_2685066" "unprognostic (2.14e-1)" "unprognostic (6.79e-3)" "unprognostic (6.82e-2)" "unprognostic (1.36e-1)" "unprognostic (1.31e-2)" 0.1 235.6 0.3 0.1 0.2 0.4 0.0 0.7 0.4 0.0 0.5 0.6 59.5 0.1 0.4 0.0 0.0 0.1 0.0 0.2 0.1 0.2 1072.1 0.0 0.2 0.2 0.3 0.1 0.1 36.9 0.0 0.1 0.2 0.1 0.9 1.0 0.1 3.1 0.1 0.3 86.6 0.0 0.0 0.4 24.4 4.2 0.2 0.0 0.1 0.0 0.1 2.0 0.1 0.6 0.1 0.0 0.1 0.1 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.9 0.1 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.1 0.2 0.3 39.6 0.0 0.9 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.4 0.0 0.0 0.1 0.3 0.1 0.1 0.1 0.0 0.5 0.3 0.0 26.7 0.2 0.2 0.2 0.0 0.0 0.0 0.1 0.3 0.0 0.1 0.1 0.2 0.1 0.2 0.1 0.2 0.0 0.2 0.1 2.9 0.2 0.2 0.2 0.1 0.2 0.2 0.3 0.2 0.1 0.4 0.4 0.3 0.8 0.5 0.1 0.3 0.2 0.2 0.3 0.2 0.7 0.4 0.2 0.1 0.2 0.3 0.2 0.0 0.2 0.6 0.0 0.0 0.0 0.3 2.9 0.1 0.6 0.0 0.0 1.3 0.0 0.0 0.6 18.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 1.3 0.0 18.7 0.3 0.0 0.0 0.3 5.1 0.1 0.0 0.1 30.0 1578.7 0.0 0.0 0.3 2.8 0.0 31.8 0.4 0.2 3.1 0.0 0.0 0.0 0.0 0.1 0.0 0.5 0.1 0.0 8.8 0.4 0.0 0.3 171.7 0.1 0.0 2.7 0.0 0.2 0.2 0.1 0.0 0.0 0.0 0.5 1.8 81.7 2.2 0.3 SULT2B1 HSST2 ENSG00000088002 "Sulfotransferase family 2B member 1" O00204 19 48552172-48599425 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Lipid metabolism, Steroid metabolism" Transferase "Disease variant, Ichthyosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 286.0;skin 1: 186.5;vagina: 145.9" "Cell type enhanced" "Detected in many" "Prostatic glandular cells: 62.3;Proximal enterocytes: 75.9;Squamous epithelial cells: 56.0;Suprabasal keratinocytes: 137.4;Urothelial cells: 114.6" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "CAPAN-2: 74.2;MCF7: 46.8;OE19: 122.9;T-47d: 36.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA041724, HPA043539, HPA076510" Enhanced Enhanced Vesicles,Cytosol NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 21: OE19 - Mitochondria" "Cluster 22: Epithelial cell types - Mixed function" Vesicles Cytosol "HPA041724: AB_2677638, HPA043539: AB_2678540, HPA076510: " "unprognostic (6.55e-2)" "unprognostic (1.47e-1)" "unprognostic (5.28e-3)" "unprognostic (8.74e-2)" "unprognostic (5.00e-2)" "unprognostic (5.97e-2)" "unprognostic (4.43e-2)" "unprognostic (3.29e-3)" "unprognostic (1.62e-1)" "unprognostic (1.11e-2)" "unprognostic (2.54e-2)" "unprognostic (4.42e-2)" "unprognostic (5.01e-6)" "unprognostic (7.96e-3)" "unprognostic (1.32e-1)" "unprognostic (8.04e-2)" "unprognostic (2.77e-2)" 0.3 0.2 0.5 0.4 0.4 0.1 11.5 0.6 0.8 74.4 0.4 0.8 9.3 0.5 6.8 286.0 1.2 2.7 0.2 0.5 0.5 13.0 0.3 9.4 0.0 0.5 0.7 0.1 0.7 7.9 0.4 1.5 0.5 22.6 0.2 0.0 53.6 3.7 0.4 186.5 18.2 0.1 0.4 0.1 3.5 0.5 0.9 0.4 1.9 0.0 28.3 0.7 145.9 0.5 12.6 15.8 0.0 0.3 0.0 0.0 0.4 0.0 0.1 0.0 0.1 0.9 74.2 0.1 0.1 0.0 0.7 3.9 0.1 0.3 0.0 0.5 0.4 0.0 0.5 0.5 0.0 0.0 7.2 0.2 2.1 0.0 0.0 0.1 0.0 0.8 0.1 0.1 0.0 46.8 0.0 0.5 0.0 122.9 0.0 0.1 0.0 0.1 0.0 3.5 0.2 0.1 0.0 6.2 0.3 0.0 36.7 0.1 0.2 0.0 0.3 0.1 0.0 0.1 0.1 0.1 0.0 0.4 0.3 0.5 0.1 0.0 0.3 0.2 0.6 0.0 0.2 0.1 0.1 0.0 0.0 0.1 0.1 0.2 0.2 0.2 0.1 0.2 0.5 0.4 0.6 0.8 0.5 0.5 0.5 0.7 0.5 0.4 0.9 0.5 0.4 19.2 0.5 1.0 0.0 24.1 30.5 11.6 0.0 0.0 16.8 12.4 0.6 5.7 40.2 9.2 0.0 3.2 0.0 4.4 0.0 12.2 0.0 15.7 1.4 0.9 4.8 0.0 1.0 1.2 3.1 1.2 2.6 17.5 0.0 0.1 0.0 0.3 0.7 0.0 0.9 12.6 24.4 0.0 4.8 0.9 0.3 0.4 12.4 1.0 0.0 1.6 0.0 0.5 0.8 18.5 7.9 0.0 0.0 62.3 75.9 1.3 6.7 0.6 0.0 0.1 2.2 0.2 11.1 56.0 137.4 1.9 0.6 2.0 9.2 114.6 SULT6B1 ENSG00000138068 "Sulfotransferase family 6B member 1" Q6IMI4 2 37167820-37196598 "Enzymes, Predicted intracellular proteins" Transferase "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at transcript level" "Tissue enhanced" "Detected in some" "brain: 1.6;testis: 2.4" "Group enriched" "Detected in some" 8 "Early spermatids: 3.5;Late spermatids: 1.8;Spermatocytes: 2.1" "Not detected" "Not detected" "Region enhanced" "Detected in single" "cerebral cortex: 1.6" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 6 "WM-115: 2.3" "Not detected" "Not detected" "Low region specificity" "Detected in single" NA NA "Cluster 34: Basophils - Unknown function" "Cluster 78: Testis - Spermatogenesis" "Cluster 17: WM-115 - Nervous system development" "Cluster 66: Spermatocytes - Spermatogenesis" "unprognostic (1.86e-1)" "unprognostic (8.98e-2)" 0.0 0.0 0.3 0.0 0.1 0.3 0.0 0.1 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.2 0.4 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 2.4 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.1 1.6 0.3 0.1 0.2 0.4 0.3 0.1 0.3 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.5 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 2.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 SUV39H1 "KMT1A, SUV39H" ENSG00000101945 "Suppressor of variegation 3-9 homolog 1" O43463 X 48695554-48709016 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Biological rhythms, Cell cycle, Differentiation, Host-virus interaction, rRNA processing, Transcription, Transcription regulation" "Chromatin regulator, Methyltransferase, Repressor, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 28.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA Yes "Cluster 27: Non-specific - Gene expression" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 38: Extravillous trophoblasts - Unknown function" "unprognostic (4.92e-2)" "prognostic favorable (8.93e-5)" "unprognostic (9.51e-2)" "unprognostic (4.18e-2)" "unprognostic (1.75e-1)" "unprognostic (1.66e-2)" "unprognostic (1.36e-2)" "unprognostic (1.94e-1)" "unprognostic (1.03e-1)" "unprognostic (3.59e-2)" "unprognostic (1.13e-1)" "unprognostic (2.43e-1)" "prognostic unfavorable (1.91e-7)" "unprognostic (2.29e-3)" "unprognostic (6.47e-3)" "unprognostic (2.01e-1)" "unprognostic (5.67e-2)" 4.0 2.2 4.7 4.2 4.4 13.7 3.5 4.9 5.1 2.9 2.0 3.4 3.1 3.2 12.5 5.0 3.3 1.7 3.6 4.3 5.1 2.6 6.6 2.7 7.5 5.2 5.6 3.8 2.9 2.3 3.0 3.3 4.8 3.0 3.2 3.3 2.6 3.0 4.9 4.4 4.2 2.6 3.9 6.0 3.6 4.9 5.0 9.7 2.6 3.8 7.0 3.4 2.4 4.3 28.7 34.3 13.3 14.0 3.4 4.0 27.0 13.5 10.2 25.8 21.0 21.0 18.7 31.4 8.0 9.9 26.1 19.8 33.0 19.3 15.4 24.2 33.8 12.3 31.8 17.4 2.0 30.7 6.6 3.6 3.7 22.8 11.6 4.2 18.6 20.2 31.9 21.6 14.2 33.1 26.8 32.0 15.7 14.0 32.8 19.3 24.5 33.1 8.6 15.7 17.4 11.4 18.3 17.4 9.8 14.8 26.0 25.5 10.0 15.8 27.0 22.1 23.3 14.6 23.9 26.4 11.8 43.6 17.7 4.9 2.8 6.8 8.5 4.0 6.2 4.6 5.5 9.1 2.2 5.4 6.8 6.6 2.0 10.6 6.5 2.6 11.0 6.5 4.7 4.4 4.9 5.1 4.3 5.1 5.2 5.6 4.8 3.9 5.0 4.3 1.2 6.4 0.0 0.3 3.5 1.8 0.9 2.0 2.8 5.3 2.2 2.5 2.5 2.8 1.3 1.8 0.0 6.5 6.6 2.1 3.9 2.9 0.2 1.3 0.9 1.7 3.0 6.9 0.7 2.9 28.3 1.9 3.1 1.0 1.3 2.9 1.8 6.7 5.2 0.0 1.0 2.6 0.0 2.9 1.6 0.2 1.2 2.4 5.4 1.0 3.0 0.9 6.2 1.0 0.8 2.3 1.7 1.5 7.1 0.6 1.6 2.4 2.6 3.8 0.0 1.8 2.5 3.7 0.8 2.5 1.1 6.2 3.6 1.7 3.2 0.6 SUV39H2 "FLJ23414, KMT1B" ENSG00000152455 "Suppressor of variegation 3-9 homolog 2" Q9H5I1 10 14878820-14904315 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Biological rhythms, Cell cycle, Differentiation, Transcription, Transcription regulation" "Chromatin regulator, Methyltransferase, Repressor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 5 "testis: 39.3" "Cell type enriched" "Detected in many" 4 "Early spermatids: 421.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045901, HPA057554" Enhanced Uncertain Mitochondria NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 23: Spermatids - Flagellum & Golgi organization" Mitochondria "HPA045901: AB_10960702, HPA057554: AB_2683466" "prognostic unfavorable (5.55e-4)" "unprognostic (1.45e-1)" "unprognostic (2.98e-2)" "unprognostic (8.78e-3)" "unprognostic (6.80e-2)" "unprognostic (1.23e-3)" "prognostic unfavorable (2.01e-6)" "unprognostic (1.06e-1)" "unprognostic (9.15e-2)" "unprognostic (3.59e-3)" "unprognostic (2.42e-1)" "unprognostic (4.13e-3)" "prognostic unfavorable (5.71e-5)" "unprognostic (2.71e-2)" "unprognostic (1.40e-1)" "unprognostic (5.55e-2)" "unprognostic (1.39e-1)" 2.1 1.5 1.4 2.4 1.8 4.7 3.8 8.3 3.5 1.6 1.4 2.9 2.0 2.0 1.5 3.1 2.1 1.7 1.0 1.5 1.2 2.4 3.1 1.3 2.5 1.2 1.4 2.5 1.8 1.9 1.3 3.8 1.2 2.7 3.4 3.4 1.7 2.3 1.4 1.9 2.6 2.3 1.2 1.5 1.8 39.3 1.3 6.1 1.4 1.2 3.1 3.1 1.4 3.1 28.6 20.8 40.8 24.1 7.5 10.7 16.9 14.8 8.1 24.1 34.6 29.5 15.2 22.4 13.4 5.8 22.6 21.3 27.7 16.4 31.6 22.9 15.1 29.4 14.0 21.5 4.3 14.8 16.2 4.1 5.3 24.2 5.4 6.4 19.0 37.4 41.9 15.2 20.3 19.3 31.3 4.4 28.8 26.6 5.9 38.4 28.1 20.7 10.9 11.0 13.8 16.8 23.9 16.6 11.1 23.8 24.6 11.0 11.6 21.4 31.7 22.9 23.1 9.5 36.1 47.9 12.1 14.8 13.5 0.2 0.3 0.2 1.5 1.1 1.9 0.4 1.1 1.7 1.1 0.3 1.8 1.8 0.3 3.0 0.4 1.8 2.0 0.5 1.4 1.8 8.3 3.5 1.5 1.2 1.2 1.4 1.2 1.2 1.3 3.1 2.0 0.0 1.5 4.2 2.6 8.3 10.2 6.7 9.1 7.5 4.0 3.7 2.9 2.8 7.5 1.8 10.4 13.9 1.7 1.1 5.9 4.4 421.0 3.4 5.1 4.3 3.5 16.2 8.0 2.2 25.6 5.1 4.1 4.0 2.5 7.8 1.8 3.0 5.0 11.8 7.9 3.1 6.1 1.6 2.8 104.4 4.7 1.8 1.8 2.8 0.7 4.2 3.1 4.5 4.5 2.1 1.7 2.6 7.1 14.5 1.0 7.4 3.5 10.2 6.6 5.8 6.6 47.5 46.6 8.3 8.8 8.9 3.4 8.7 4.5 10.9 SYK ENSG00000165025 "Spleen associated tyrosine kinase" P43405 9 90801787-90898549 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Predicted intracellular proteins" "Adaptive immunity, Angiogenesis, Host-virus interaction, Immunity, Innate immunity" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 73.8;parathyroid gland: 87.6" "Cell type enhanced" "Detected in many" "B-cells: 91.3;Hofbauer cells: 73.1;Kupffer cells: 96.7;Macrophages: 95.2;Microglial cells: 114.3;monocytes: 92.5;Plasma cells: 83.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 13 "classical monocyte: 77.3;eosinophil: 83.5;intermediate monocyte: 64.0;memory B-cell: 74.5;myeloid DC: 85.1;naive B-cell: 58.4;neutrophil: 112.1;NK-cell: 30.0;non-classical monocyte: 60.2;plasmacytoid DC: 63.2" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "Daudi: 125.8;HEL: 72.8;HL-60: 101.6;HMC-1: 64.1;REH: 84.4;THP-1: 76.8;U-698: 58.8;U-937: 70.3" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA001384, CAB007773" Enhanced Approved "Vesicles,Plasma membrane,Cytosol" No NA 290000 "Cluster 5: Granulocytes - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 3: HMC-1 - Innate immune response" "Cluster 57: B-cells - Immune response" "Plasma membrane, Cytosol" Vesicles "CAB007773: AB_562232, HPA001384: AB_1080144" "unprognostic (1.01e-1)" "unprognostic (5.45e-2)" "unprognostic (2.10e-1)" "unprognostic (2.69e-2)" "unprognostic (2.31e-1)" "unprognostic (7.92e-2)" "unprognostic (1.06e-1)" "unprognostic (1.34e-1)" "unprognostic (6.41e-2)" "unprognostic (1.78e-2)" "unprognostic (7.20e-2)" "unprognostic (9.93e-2)" "unprognostic (2.55e-3)" "unprognostic (8.77e-2)" "unprognostic (5.36e-3)" "unprognostic (3.41e-2)" "unprognostic (1.06e-2)" 7.4 4.6 4.1 42.5 4.1 50.9 6.8 4.5 4.9 7.7 4.2 20.1 30.8 4.1 16.1 17.5 17.0 12.9 2.9 3.8 5.0 11.2 4.5 20.6 61.8 7.1 5.8 1.7 9.1 87.6 2.4 12.0 7.0 3.8 20.5 0.7 8.4 4.2 1.0 9.9 36.3 9.3 6.6 40.3 19.1 6.9 7.1 49.7 25.6 2.4 73.8 17.5 8.3 9.8 22.7 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 14.3 125.8 3.5 0.0 4.2 19.1 2.7 10.2 0.0 0.0 17.0 72.8 0.0 0.0 0.0 101.6 64.1 0.0 14.0 0.0 1.4 0.0 0.0 15.5 2.0 9.9 0.0 15.4 0.1 44.4 0.7 47.0 0.0 84.4 0.1 34.6 2.6 18.6 6.4 5.7 0.1 8.7 0.1 0.3 7.9 76.8 0.2 0.0 0.4 0.1 0.1 0.2 0.0 58.8 0.0 70.3 0.0 5.3 77.3 83.5 0.3 64.0 0.3 74.5 0.2 0.2 85.1 58.4 0.2 0.1 112.1 30.0 60.2 63.2 0.1 44.6 4.1 4.1 4.5 4.9 3.8 5.0 7.1 5.8 7.0 6.6 7.1 9.8 0.5 12.8 20.2 0.0 91.3 3.4 3.7 8.7 12.0 1.4 6.3 2.8 1.6 14.3 12.8 14.7 0.0 1.3 70.4 16.5 15.6 15.0 7.1 10.7 1.0 2.1 10.3 37.9 0.4 12.5 2.6 2.1 22.4 12.6 43.6 0.0 3.3 1.0 73.1 0.0 0.7 24.4 0.0 96.7 28.8 6.2 0.6 95.2 12.4 114.3 92.5 0.0 62.8 1.5 0.5 18.2 25.1 0.0 83.1 2.5 31.4 0.4 10.4 0.2 6.6 0.7 2.3 0.8 0.7 30.4 5.7 1.4 8.3 0.0 31.1 8.0 SYVN1 "DER3, HRD1" ENSG00000162298 "Synoviolin 1" Q86TM6 11 65121780-65134532 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Stress response, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hepatocytes: 72.9;Plasma cells: 90.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-698: 205.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA005480, HPA024300, CAB037030" Enhanced Supported "Nucleoplasm,Endoplasmic reticulum,Plasma membrane" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 29: Non-specific - Vesicular transport" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 57: B-cells - Immune response" Nucleoplasm "Endoplasmic reticulum, Plasma membrane" "CAB037030: AB_1840939, HPA005480: AB_1079084, HPA024300: AB_1851073" "unprognostic (1.12e-1)" "unprognostic (3.10e-1)" "unprognostic (1.22e-1)" "unprognostic (2.17e-2)" "unprognostic (2.85e-2)" "prognostic favorable (6.88e-4)" "unprognostic (7.67e-2)" "unprognostic (2.50e-2)" "unprognostic (2.64e-2)" "unprognostic (1.30e-1)" "unprognostic (1.59e-1)" "unprognostic (1.12e-1)" "unprognostic (1.77e-2)" "unprognostic (1.56e-2)" "unprognostic (4.89e-1)" "unprognostic (3.85e-2)" "unprognostic (1.16e-1)" 29.2 40.3 19.3 37.1 25.6 31.0 27.6 23.2 21.4 30.7 26.7 29.2 26.1 29.1 38.8 28.4 30.6 19.7 25.3 18.6 21.2 24.5 117.5 27.0 60.9 27.9 25.6 30.9 90.9 35.0 38.2 26.2 24.6 28.5 29.0 18.7 55.9 30.3 34.2 29.3 39.4 25.9 22.8 51.2 39.4 24.3 23.4 18.3 43.4 19.0 81.1 25.8 24.8 25.9 32.4 40.6 24.0 32.5 59.8 33.8 23.8 32.8 33.5 40.9 28.8 22.2 55.0 181.0 43.8 42.4 53.8 48.8 26.4 33.3 33.6 28.4 20.0 28.6 46.8 50.2 72.3 43.3 49.6 43.3 59.0 36.1 81.0 36.4 27.0 19.0 36.4 90.1 24.3 47.9 19.1 31.2 26.1 33.6 28.0 31.9 20.3 74.0 25.7 31.5 15.6 32.0 30.4 74.1 53.3 21.0 55.4 28.2 25.9 28.3 18.6 51.2 22.4 178.1 134.2 205.9 38.1 21.8 32.3 16.8 7.4 14.0 7.4 4.7 6.5 21.9 5.2 6.9 4.4 22.6 3.7 3.9 7.0 3.5 4.7 18.4 5.3 6.6 19.3 25.6 23.2 21.4 18.6 21.2 27.9 25.6 24.6 22.8 23.4 25.9 11.5 16.0 21.4 11.1 43.5 17.6 6.9 13.8 12.0 10.7 21.0 15.5 4.0 22.8 20.8 11.0 33.3 14.5 16.4 23.1 1.9 13.6 6.6 14.2 16.2 11.3 8.4 13.2 9.6 18.9 16.5 14.2 17.9 22.1 1.3 10.1 15.0 72.9 15.1 13.5 9.5 33.6 16.2 15.3 13.2 4.1 20.5 10.8 12.4 9.4 10.5 11.0 13.4 13.0 15.8 18.2 11.7 13.2 90.5 14.9 14.0 7.7 15.1 18.7 13.1 11.9 10.7 19.3 13.2 9.7 16.1 42.8 11.7 13.6 18.6 13.8 TAF1 "BA2R, CCG1, CCGS, DYT3, DYT3/TAF1, KAT4, NSCL2, TAF2A, TAFII250" ENSG00000147133 "TATA-box binding protein associated factor 1" P21675 X 71366264-71532374 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Transcription factors" "Cell cycle, Host-virus interaction, Transcription, Transcription regulation" "Acyltransferase, DNA-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Dystonia, Mental retardation, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cone photoreceptor cells: 81.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "HPA001075, CAB016283" Supported Supported Nucleoplasm NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 32: U-937 - Innate immune response" "Cluster 9: Photoreceptor cells - Phototransduction" Nucleoplasm "CAB016283: AB_671202, HPA001075: AB_1080179" "unprognostic (2.95e-2)" "unprognostic (1.77e-1)" "unprognostic (6.45e-3)" "unprognostic (1.91e-2)" "unprognostic (1.88e-2)" "unprognostic (1.23e-1)" "unprognostic (1.44e-1)" "prognostic favorable (6.54e-4)" "unprognostic (2.68e-2)" "unprognostic (3.43e-2)" "unprognostic (2.03e-1)" "unprognostic (5.59e-2)" "prognostic unfavorable (6.03e-4)" "unprognostic (1.14e-2)" "unprognostic (1.41e-1)" "unprognostic (1.82e-2)" "unprognostic (2.56e-2)" 10.9 8.6 10.3 11.4 12.7 12.8 12.3 13.7 11.1 11.1 10.2 10.0 6.6 13.8 12.9 7.5 11.1 7.8 7.0 9.3 14.1 7.5 7.8 9.1 14.1 11.5 11.3 14.4 9.8 12.2 8.4 10.0 10.9 10.0 10.0 27.3 7.7 10.1 10.5 13.3 9.3 10.9 8.2 15.4 10.6 7.2 12.5 14.8 12.7 10.3 12.4 9.2 8.6 16.8 18.6 15.9 18.2 12.4 14.6 23.2 11.0 13.3 12.1 13.7 11.1 12.3 11.3 17.6 11.5 14.9 12.3 17.5 24.1 11.0 17.0 11.2 21.9 20.1 22.1 13.1 11.1 39.7 19.4 14.1 11.3 14.2 27.2 12.8 14.7 13.2 28.2 41.1 14.4 14.5 22.4 25.4 20.9 23.5 20.8 19.8 35.8 21.6 11.1 25.0 9.0 14.5 37.7 13.6 18.7 14.3 9.6 22.9 18.6 16.5 14.2 13.4 9.7 17.5 17.4 21.4 9.0 33.2 12.5 1.6 1.4 0.7 1.4 0.9 1.3 1.0 1.4 1.4 1.5 1.5 1.6 1.8 1.8 1.5 1.6 1.4 1.0 0.7 10.3 12.7 13.7 11.1 9.3 14.1 11.5 11.3 10.9 8.2 12.5 16.8 26.7 32.1 26.7 44.7 21.2 11.9 8.9 10.4 18.2 37.5 12.5 13.3 17.2 10.0 23.9 3.7 81.3 8.6 21.5 7.8 1.9 6.3 2.5 17.0 23.4 24.6 11.4 28.6 54.3 7.0 5.9 17.6 12.2 18.9 23.4 23.9 18.9 12.6 8.8 16.8 52.2 14.6 6.1 16.2 20.0 2.6 22.1 20.4 5.4 47.8 23.9 17.0 29.9 49.3 79.1 7.6 13.3 22.2 18.7 11.2 13.4 5.2 14.8 67.9 0.0 27.4 18.0 9.3 10.7 17.8 17.3 5.7 23.8 25.9 13.6 9.6 TALDO1 ENSG00000177156 "Transaldolase 1" P37837 11 747415-765012 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Pentose shunt" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "monocytes: 820.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "eosinophil: 2870.4;neutrophil: 3726.6" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA048089 Approved Nucleoplasm,Cytosol NA NA 29000000 "Cluster 5: Granulocytes - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 3: Monocytes - Immune response regulation" Nucleoplasm Cytosol "HPA048089: AB_2680260" "unprognostic (5.29e-2)" "unprognostic (1.78e-2)" "unprognostic (3.47e-1)" "unprognostic (9.65e-3)" "unprognostic (2.97e-2)" "unprognostic (4.15e-2)" "prognostic unfavorable (2.29e-4)" "unprognostic (9.78e-2)" "unprognostic (4.27e-2)" "unprognostic (1.74e-1)" "unprognostic (7.97e-3)" "unprognostic (2.94e-1)" "unprognostic (1.59e-1)" "unprognostic (9.99e-2)" "unprognostic (1.20e-1)" "unprognostic (2.37e-1)" "unprognostic (1.16e-3)" 139.5 80.7 108.0 121.8 128.8 464.8 121.0 129.3 119.3 101.9 105.2 99.6 116.0 68.4 66.4 330.6 79.1 100.0 95.5 108.0 113.8 111.6 136.2 109.1 107.8 135.8 119.3 77.0 107.5 49.3 53.0 88.0 130.0 91.9 78.4 34.2 132.8 60.1 120.7 132.7 101.0 60.8 124.0 152.6 132.5 40.4 120.1 109.9 140.3 107.1 115.8 160.8 142.1 148.2 331.0 405.5 115.4 218.1 235.8 136.5 338.0 242.2 313.8 238.2 194.5 176.6 694.8 179.5 323.1 324.7 181.9 345.5 185.6 263.5 122.8 238.9 372.5 310.9 146.0 616.4 250.3 498.4 449.0 112.0 210.6 159.6 129.0 170.4 331.6 224.0 413.5 294.3 224.5 318.0 296.4 601.2 183.9 478.9 326.0 243.5 131.5 656.4 437.9 185.4 284.2 100.1 224.9 466.1 243.3 102.4 220.0 383.9 434.1 107.9 99.5 86.0 232.9 122.9 132.1 223.5 238.5 440.5 444.7 1456.7 1203.5 2870.4 94.1 432.7 102.3 145.5 125.7 115.5 654.2 127.2 100.9 94.9 3726.6 112.2 457.8 267.0 192.7 1066.0 108.0 128.8 129.3 119.3 108.0 113.8 135.8 119.3 130.0 124.0 120.1 148.2 90.2 141.1 117.2 10.7 91.1 73.5 199.8 354.0 61.5 50.3 113.0 122.2 46.4 100.1 253.4 150.8 14.6 419.8 83.8 151.0 250.5 230.4 82.1 156.5 85.4 85.6 101.5 507.0 13.1 272.1 427.6 97.3 144.3 216.7 161.4 86.0 93.5 149.7 418.3 50.5 11.6 186.0 268.5 271.8 169.4 21.2 117.8 352.8 140.5 7.5 820.0 142.1 84.5 10.6 54.8 257.6 200.3 104.2 129.4 361.9 197.7 309.1 232.6 61.7 72.3 59.6 115.0 143.2 140.6 257.6 83.1 526.6 86.8 77.5 215.1 342.6 TAMM41 "C3orf31, DKFZp434E0519, MGC16471" ENSG00000144559 "TAM41 mitochondrial translocator assembly and maintenance homolog" Q96BW9 3 11790442-11846919 "Enzymes, Predicted intracellular proteins" "Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism" "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036834, HPA044861" Uncertain Approved Cytosol NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 50: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Cytosol "HPA036834: AB_10672270, HPA044861: AB_2679116" "unprognostic (2.40e-2)" "unprognostic (4.41e-2)" "prognostic favorable (1.23e-4)" "unprognostic (4.45e-2)" "unprognostic (1.44e-2)" "unprognostic (5.60e-2)" "unprognostic (2.03e-5)" "unprognostic (1.57e-1)" "unprognostic (2.35e-1)" "unprognostic (3.95e-1)" "unprognostic (1.60e-1)" "unprognostic (7.33e-3)" "unprognostic (3.78e-2)" "unprognostic (2.04e-1)" "unprognostic (1.63e-1)" "unprognostic (7.34e-2)" "unprognostic (3.59e-3)" 8.3 7.4 5.8 5.6 6.2 4.3 8.0 6.4 8.5 8.0 2.6 6.5 4.9 7.2 9.7 9.0 6.9 4.1 8.0 5.3 6.9 6.7 5.5 5.0 7.1 3.9 4.1 11.0 5.6 5.8 5.6 4.1 4.0 5.2 4.9 6.3 6.8 4.5 9.2 10.1 6.2 6.2 2.8 6.5 6.0 5.7 5.4 6.5 6.0 5.2 7.8 8.4 8.2 6.2 6.2 11.3 13.5 9.4 14.3 18.0 24.9 9.3 6.6 13.9 13.8 13.6 9.9 23.4 13.3 9.8 6.2 7.4 22.9 13.9 17.9 8.8 21.6 14.0 10.6 15.9 16.7 25.8 7.1 10.3 20.3 13.1 14.6 9.1 21.8 18.3 20.8 7.0 18.0 17.8 14.6 19.2 10.9 9.6 23.8 14.4 7.7 20.7 21.6 14.8 6.2 5.4 8.1 10.3 16.6 15.1 13.5 11.6 5.7 7.2 8.3 21.8 13.5 5.4 14.2 12.1 8.8 21.8 6.7 1.9 4.5 7.1 5.7 3.2 7.6 7.5 9.1 5.8 7.8 7.1 8.4 8.8 0.2 6.9 6.7 5.8 7.7 4.8 5.8 6.2 6.4 8.5 5.3 6.9 3.9 4.1 4.0 2.8 5.4 6.2 9.4 6.4 7.0 24.5 11.4 4.2 8.1 15.7 5.7 11.5 5.5 8.3 8.9 0.0 8.7 3.7 12.5 12.2 8.6 3.3 9.8 10.1 2.2 5.4 9.2 7.6 3.0 9.4 34.5 9.3 11.0 7.2 6.6 4.4 2.5 10.5 5.7 5.8 9.2 10.1 34.7 8.1 12.2 6.4 6.4 1.5 7.8 6.8 3.6 14.0 5.9 11.0 10.3 34.7 32.0 7.9 3.4 6.4 7.1 6.7 4.2 10.3 11.8 14.7 0.0 8.6 8.7 7.4 12.4 6.6 4.1 7.0 9.5 10.8 7.3 5.9 TAOK1 "FLJ14314, KIAA1361, MAP3K16, MARKK, PSK2, TAO1" ENSG00000160551 "TAO kinase 1" Q7L7X3 17 29390363-29551903 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, DNA damage, DNA repair" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 220.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007669 Approved Uncertain Vesicles NA NA 1600000 "Cluster 1: Neutrophils - Mixed function" "Cluster 21: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Vesicles "HPA007669: AB_1080201" "unprognostic (1.46e-1)" "unprognostic (7.15e-3)" "unprognostic (2.70e-2)" "unprognostic (1.52e-1)" "unprognostic (1.81e-2)" "unprognostic (4.85e-2)" "unprognostic (1.28e-2)" "unprognostic (4.31e-2)" "unprognostic (1.15e-1)" "unprognostic (6.91e-2)" "unprognostic (1.61e-1)" "unprognostic (1.36e-1)" "unprognostic (2.85e-2)" "unprognostic (5.53e-3)" "unprognostic (3.57e-1)" "unprognostic (1.66e-1)" "unprognostic (2.62e-1)" 13.7 9.1 12.0 9.8 16.0 10.5 10.3 13.8 13.1 11.8 1.2 9.5 5.2 10.8 8.5 10.3 7.9 9.6 13.2 13.3 12.8 10.2 8.6 9.8 9.9 16.4 14.5 10.3 7.8 19.4 8.0 11.7 14.9 9.0 8.5 20.9 7.8 10.0 11.4 10.4 7.3 11.7 13.2 10.4 8.1 11.7 13.9 13.2 14.5 15.2 9.5 12.1 8.7 20.4 19.3 35.0 32.1 13.4 24.1 29.8 11.3 20.0 23.9 20.3 21.1 20.7 7.9 13.8 15.8 35.9 20.7 16.3 30.4 15.7 36.4 20.7 18.2 21.0 21.3 12.2 16.6 26.5 16.7 19.4 19.6 29.0 30.6 21.3 27.3 14.0 20.7 12.0 26.7 14.2 18.5 9.5 12.0 12.9 8.6 15.1 41.2 8.8 19.1 31.5 16.1 18.7 34.6 34.4 21.1 32.6 23.6 21.6 33.6 28.0 19.7 23.7 27.5 9.3 18.6 14.0 20.3 14.8 24.3 0.6 0.5 0.5 0.6 0.6 0.5 0.5 0.6 0.7 0.5 0.6 0.7 0.7 1.7 0.5 0.6 1.4 0.4 0.3 12.0 16.0 13.8 13.1 13.3 12.8 16.4 14.5 14.9 13.2 13.9 20.4 96.9 48.1 45.8 105.8 35.9 44.5 27.4 27.0 52.9 56.6 35.5 23.2 90.2 30.0 37.7 46.0 98.0 18.7 40.5 29.3 15.6 27.3 11.8 45.0 72.0 55.4 37.7 18.7 162.3 24.3 16.0 58.0 31.6 80.1 28.5 44.3 52.1 29.5 30.1 52.2 160.5 23.7 24.4 65.6 60.4 19.8 39.7 67.3 40.9 92.8 55.8 37.1 29.9 142.2 220.8 38.9 24.0 54.2 34.2 40.4 17.6 22.1 31.0 54.7 26.3 66.1 52.1 59.1 33.2 49.5 45.9 37.6 43.1 43.0 21.1 41.6 TAOK2 "KIAA0881, MAP3K17, PSK, PSK1, TAO1, TAO2" ENSG00000149930 "TAO kinase 2" Q9UL54 16 29973868-29992261 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Adipocytes: 52.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA010650 Approved Approved Nucleoplasm,Nucleoli,Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 72: Non-specific - Transcription" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Nucleoplasm, Cytosol" Nucleoli "HPA010650: AB_1080204" "unprognostic (7.30e-2)" "unprognostic (1.78e-1)" "prognostic unfavorable (2.51e-4)" "prognostic favorable (3.87e-5)" "unprognostic (8.46e-2)" "unprognostic (2.14e-3)" "unprognostic (6.08e-2)" "unprognostic (1.12e-3)" "unprognostic (1.01e-2)" "unprognostic (1.60e-1)" "prognostic favorable (4.78e-4)" "unprognostic (3.85e-3)" "prognostic favorable (3.66e-4)" "unprognostic (7.42e-3)" "unprognostic (3.17e-1)" "unprognostic (7.47e-2)" "unprognostic (1.37e-1)" 31.4 36.0 23.4 14.7 21.2 12.7 30.8 18.0 26.1 24.8 11.9 21.8 17.3 25.9 11.1 20.8 22.6 12.0 32.6 23.0 18.9 22.7 17.6 34.0 14.4 21.0 20.0 24.1 19.5 17.4 29.4 19.4 18.9 22.5 8.5 14.3 20.5 13.3 23.4 22.4 24.4 13.3 15.3 33.8 21.8 34.8 20.8 13.2 25.4 12.7 10.5 22.4 21.6 19.0 22.2 41.8 22.4 35.1 25.8 17.1 34.2 40.0 21.1 26.4 24.4 33.6 28.7 23.8 32.8 28.8 18.0 33.9 20.4 20.0 14.1 37.5 43.3 25.8 46.2 34.8 18.7 25.5 47.5 20.0 17.1 28.1 11.2 18.5 44.7 22.4 23.5 23.6 25.8 41.0 29.8 36.0 21.5 16.4 27.6 54.2 32.5 22.2 16.6 20.5 26.1 20.8 22.8 30.2 12.1 14.4 37.5 28.5 62.9 45.0 20.7 32.4 23.6 34.2 23.7 22.1 27.6 28.8 33.7 0.3 0.7 0.4 0.7 0.7 0.8 0.5 0.7 0.6 0.4 0.6 0.4 0.3 1.2 0.5 0.4 0.8 0.9 0.6 23.4 21.2 18.0 26.1 23.0 18.9 21.0 20.0 18.9 15.3 20.8 19.0 52.0 9.6 11.5 21.9 6.3 10.7 4.6 7.5 7.4 14.6 10.5 5.7 9.8 7.2 9.1 9.2 39.6 7.8 7.6 27.0 1.9 8.5 3.9 8.7 9.5 35.3 13.1 3.4 7.9 12.0 6.2 9.7 14.3 8.9 3.8 16.0 47.2 11.8 9.8 10.1 10.7 16.8 12.2 11.2 11.1 4.4 12.5 8.2 7.2 7.5 9.0 8.4 11.3 9.0 12.7 16.1 14.8 12.8 5.9 7.4 27.2 8.0 10.0 21.4 6.6 8.7 8.7 19.7 21.6 9.1 9.7 12.0 9.2 16.0 14.7 7.4 TAOK3 "DPK, JIK, MAP3K18" ENSG00000135090 "TAO kinase 3" Q9H2K8 12 118149801-118372907 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocyte precursor cells: 400.6;Rod photoreceptor cells: 323.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HMC-1: 123.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA017160 Approved Uncertain Mitochondria NA NA 520000 "Cluster 18: Basophils - Vesicular transport" "Cluster 20: Retina & Lymphoid tissues - Unknown function" "Cluster 3: HMC-1 - Innate immune response" "Cluster 46: Photoreceptor cells - Phototransduction" Mitochondria "HPA017160: AB_1851994" "unprognostic (3.21e-1)" "unprognostic (1.31e-1)" "unprognostic (1.65e-1)" "unprognostic (3.74e-2)" "unprognostic (5.18e-2)" "unprognostic (2.09e-1)" "unprognostic (4.80e-1)" "unprognostic (5.86e-2)" "unprognostic (1.00e-1)" "unprognostic (7.38e-2)" "unprognostic (2.76e-2)" "unprognostic (8.23e-2)" "unprognostic (1.08e-2)" "unprognostic (2.08e-2)" "unprognostic (4.14e-3)" "unprognostic (2.56e-1)" "unprognostic (1.44e-1)" 15.4 18.2 33.9 24.9 35.7 41.9 17.1 36.8 38.5 12.7 27.9 23.8 27.1 16.8 12.7 18.2 10.5 19.5 18.5 33.0 38.1 16.2 18.4 23.2 33.8 34.2 35.3 19.3 11.7 15.5 18.7 14.3 33.5 29.0 24.6 48.3 15.2 16.0 21.8 20.3 28.8 17.7 33.6 26.0 25.2 10.7 41.2 31.6 21.1 13.0 33.0 20.6 13.3 42.6 25.7 17.2 12.7 11.1 30.6 37.0 14.5 26.2 29.8 14.9 19.3 8.9 38.5 77.4 8.4 34.9 21.5 22.5 11.2 23.5 23.3 28.3 9.2 91.7 9.0 11.7 35.6 95.2 123.5 25.3 27.7 46.9 68.4 31.3 48.3 45.5 54.3 9.0 27.8 18.2 50.0 62.0 4.7 11.7 9.2 29.1 17.2 8.3 14.1 43.8 2.3 12.5 24.1 10.9 33.6 5.5 22.0 70.0 75.9 25.5 4.5 24.2 22.6 8.7 8.9 60.6 35.8 64.1 35.2 122.3 39.4 91.5 60.9 53.8 58.1 47.9 46.0 53.4 52.4 44.9 40.3 52.9 86.2 86.9 95.4 48.8 46.6 46.0 33.9 35.7 36.8 38.5 33.0 38.1 34.2 35.3 33.5 33.6 41.2 42.6 43.2 35.3 98.9 203.4 110.7 35.2 46.7 30.4 38.1 69.9 52.3 39.6 57.6 52.9 36.7 46.0 212.7 36.1 138.5 116.3 70.5 40.3 18.6 17.5 30.6 36.2 25.1 65.2 117.0 59.1 93.5 37.8 75.4 39.2 167.6 31.6 29.6 57.7 78.5 40.4 156.2 80.7 22.4 104.3 103.0 10.3 38.8 160.5 35.6 133.0 156.9 48.4 217.3 400.6 202.2 91.0 111.7 47.8 84.9 44.4 105.2 37.4 20.7 323.8 46.0 29.9 55.2 101.4 53.3 48.3 31.4 43.8 103.5 66.4 69.3 53.7 TAT ENSG00000198650 "Tyrosine aminotransferase" P17735 16 71565660-71577092 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Phenylalanine catabolism, Tyrosine catabolism" "Aminotransferase, Transferase" "Disease variant, Mental retardation, Palmoplantar keratoderma" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 22 "liver: 1272.2" "Cell type enriched" "Detected in some" 43 "Hepatocytes: 4164.8" "Cancer enriched" "Detected in some" 10 "liver cancer: 152.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "Hep G2: 2.5" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 17: Basophils - Unknown function" "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 2: Hepatocytes - Metabolism" "unprognostic (3.66e-3)" "unprognostic (1.29e-1)" "unprognostic (8.17e-2)" "unprognostic (2.21e-1)" "unprognostic (1.67e-1)" "unprognostic (1.01e-2)" "prognostic favorable (6.51e-4)" "unprognostic (1.69e-1)" "unprognostic (9.32e-2)" "unprognostic (2.27e-1)" "unprognostic (3.73e-3)" "unprognostic (1.88e-1)" "unprognostic (1.27e-4)" "unprognostic (1.19e-1)" "unprognostic (1.28e-1)" "unprognostic (1.09e-1)" "unprognostic (1.05e-2)" 0.1 0.0 0.0 0.1 0.0 0.1 58.9 0.0 0.1 0.1 0.0 0.4 0.2 0.0 0.0 0.0 0.2 0.7 0.1 0.0 0.0 0.4 1272.2 0.1 0.2 0.1 0.0 0.0 0.2 0.0 0.1 0.0 0.1 0.0 0.2 0.6 0.1 0.0 0.0 0.1 0.6 0.0 0.0 0.8 0.1 1.8 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 2.5 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.4 0.1 0.1 0.2 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.2 0.1 0.0 0.0 0.7 6.7 0.0 0.1 0.0 0.0 0.6 95.3 18.7 0.5 72.9 0.0 0.0 0.0 0.0 0.9 0.3 0.0 0.3 1.0 0.3 0.0 3.1 0.0 45.5 0.0 0.7 0.0 0.2 0.0 0.1 0.0 0.1 49.6 4164.8 0.0 0.0 0.0 0.0 0.0 72.3 0.0 0.7 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.1 2.7 0.2 0.3 1.0 0.0 0.0 0.1 1.3 1.3 0.0 0.0 0.0 3.9 0.0 0.1 0.0 TBK1 NAK ENSG00000183735 "TANK binding kinase 1" Q9UHD2 12 64452090-64502114 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Antiviral defense, Host-virus interaction, Immunity, Innate immunity" "Kinase, Serine/threonine-protein kinase, Transferase" "Amyotrophic lateral sclerosis, Disease variant, Glaucoma, Neurodegeneration" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045797, HPA060211" Uncertain Enhanced Nucleoplasm,Vesicles NA NA "Cluster 34: Basophils - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm Vesicles "HPA045797: AB_2679457, HPA060211: AB_2684222" "unprognostic (4.73e-2)" "unprognostic (8.46e-2)" "unprognostic (6.07e-3)" "unprognostic (1.90e-1)" "unprognostic (1.94e-1)" "unprognostic (1.28e-1)" "prognostic unfavorable (3.30e-4)" "unprognostic (1.26e-1)" "prognostic unfavorable (3.48e-4)" "unprognostic (1.69e-1)" "unprognostic (2.54e-2)" "unprognostic (1.24e-2)" "prognostic unfavorable (4.20e-6)" "unprognostic (4.35e-2)" "unprognostic (1.30e-1)" "unprognostic (1.26e-2)" "unprognostic (9.56e-3)" 11.6 15.3 6.0 10.1 6.1 16.9 11.4 5.6 6.9 10.6 5.3 10.5 15.1 11.0 6.7 11.3 9.5 10.1 9.4 5.8 5.6 11.8 17.4 12.9 14.6 6.5 6.9 9.6 7.5 11.6 9.8 13.7 6.1 10.6 8.5 6.3 10.2 9.0 18.4 8.6 11.4 10.8 5.3 13.4 10.2 23.5 6.7 6.8 8.5 14.9 12.9 16.0 10.2 7.1 23.3 24.2 11.1 10.6 24.7 26.1 29.0 22.9 37.6 22.5 21.1 14.9 12.4 31.5 21.4 26.8 34.4 19.0 19.4 20.0 26.4 29.5 17.1 33.0 15.3 19.1 30.2 35.2 36.4 18.5 19.1 23.1 23.6 42.3 32.4 11.0 27.9 38.7 31.6 27.0 0.9 17.0 29.9 22.9 13.8 14.9 15.3 31.8 25.1 36.9 9.8 14.7 33.3 36.0 23.5 23.5 33.1 24.9 25.9 20.2 18.1 14.9 24.0 25.4 54.3 30.3 28.1 18.6 26.1 41.8 10.1 24.3 13.9 17.7 16.3 12.8 10.1 15.2 12.2 10.1 2.8 8.7 17.8 26.6 15.5 2.1 13.6 10.0 6.0 6.1 5.6 6.9 5.8 5.6 6.5 6.9 6.1 5.3 6.7 7.1 23.7 19.2 20.5 28.4 21.6 11.0 25.7 20.1 15.4 17.0 14.9 9.1 10.9 8.6 23.4 22.0 10.4 28.8 30.0 14.1 11.7 19.3 34.5 19.2 17.9 28.6 17.3 18.3 50.5 23.6 32.6 21.3 15.3 30.2 43.1 17.5 16.8 17.1 20.2 18.5 42.2 10.5 12.2 23.0 30.2 29.2 19.3 31.1 14.2 46.9 31.4 12.7 33.0 39.2 52.3 16.9 10.9 20.7 25.6 43.7 13.6 12.3 20.8 16.3 26.3 22.4 18.7 68.9 12.7 14.0 14.9 92.6 27.1 11.5 10.1 41.6 TEC PSCTK4 ENSG00000135605 "Tec protein tyrosine kinase" P42680 4 48135783-48269838 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Adaptive immunity, Immunity" "Kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 13.9;Glandular and luminal cells: 25.1;granulocytes: 19.6;Plasma cells: 15.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in some" "Group enriched" "Detected in some" 5 "basophil: 20.7;eosinophil: 13.3" "Lineage enriched" "Detected in many" 6 "granulocytes: 20.7" "Cell line enhanced" "Detected in many" "HEL: 13.5;HMC-1: 20.3;U-266/70: 20.3;U-266/84: 15.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA005733, HPA024657" Approved Supported "Plasma membrane" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 29: U-266 - Adaptive immune response" "Cluster 44: Endometrium - Transcription" "Plasma membrane" "HPA005733: AB_1857878, HPA024657: AB_2671637" "unprognostic (7.19e-2)" "unprognostic (1.44e-1)" "unprognostic (1.41e-2)" "unprognostic (4.07e-3)" "unprognostic (4.21e-2)" "unprognostic (8.57e-2)" "unprognostic (3.14e-1)" "unprognostic (1.67e-1)" "unprognostic (8.36e-2)" "prognostic favorable (7.12e-4)" "unprognostic (7.46e-3)" "unprognostic (7.83e-2)" "unprognostic (1.01e-4)" "unprognostic (4.24e-2)" "unprognostic (2.16e-1)" "unprognostic (7.39e-2)" "unprognostic (4.96e-3)" 0.9 1.7 0.1 2.1 0.2 6.1 1.4 0.1 0.4 1.2 1.0 1.3 1.6 1.1 4.2 3.4 1.9 1.1 1.3 0.0 0.4 1.1 2.5 2.0 3.1 1.1 0.3 0.4 0.8 1.2 0.6 1.1 1.1 0.5 1.3 1.8 2.3 1.0 0.6 3.6 1.5 0.8 0.3 1.7 1.1 1.2 0.7 2.0 1.3 0.5 3.3 1.0 1.6 0.2 3.0 0.8 0.0 0.0 0.0 0.0 0.1 0.5 2.2 1.3 2.7 0.0 2.2 1.9 2.0 0.0 0.1 0.6 1.1 0.0 1.8 0.1 0.8 13.5 1.0 0.1 0.0 2.2 20.3 0.0 0.3 1.7 0.0 1.4 0.0 0.6 7.5 0.5 4.1 1.0 1.3 4.9 0.4 1.4 0.8 3.1 2.7 0.0 3.4 0.9 0.0 0.2 0.6 0.3 0.5 1.1 0.7 4.2 0.0 0.0 0.0 2.8 0.0 20.3 15.4 2.6 0.0 3.0 0.1 20.7 0.6 13.3 0.1 0.7 0.3 1.0 0.2 0.5 1.5 0.7 0.5 0.5 0.5 3.6 0.1 0.1 0.1 0.4 0.1 0.2 0.1 0.4 0.0 0.4 1.1 0.3 1.1 0.3 0.7 0.2 0.6 6.4 6.8 0.7 6.8 2.5 1.7 0.2 2.8 0.9 1.7 1.1 1.8 7.2 2.6 0.0 0.0 1.5 3.3 2.1 0.0 1.7 6.4 13.9 1.5 1.2 3.0 12.6 6.7 1.1 0.1 0.8 0.0 25.1 19.6 0.7 0.0 2.9 4.9 0.0 1.6 1.4 4.1 4.6 1.8 2.6 0.0 5.9 1.8 10.3 1.7 6.6 0.0 0.5 0.2 1.0 0.6 0.4 15.4 1.3 3.0 2.0 0.2 3.1 6.6 1.8 0.8 0.7 1.4 9.8 3.0 0.8 3.4 0.3 2.1 1.6 TEK "CD202b, TIE-2, TIE2, VMCM, VMCM1" ENSG00000120156 "TEK receptor tyrosine kinase" Q02763 9 27109141-27230174 "Cancer-related genes, CD markers, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins, Predicted secreted proteins, RAS pathway related proteins" Angiogenesis "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes, Disease variant, FDA approved drug targets, Glaucoma" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "placenta: 46.3" "Group enriched" "Detected in many" 10 "Adipocytes: 70.8;Endothelial cells: 73.9;Hepatic stellate cells: 122.0;Microglial cells: 38.4;Oligodendrocyte precursor cells: 137.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "HUVEC TERT2: 90.9;NTERA-2: 45.2;TIME: 99.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010359, HPA073265" Approved Supported "Plasma membrane,Centriolar satellite" "Secreted to blood" NA NA 7750000 13000000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Plasma membrane" "Centriolar satellite" "CAB010359: AB_2203226, HPA073265: AB_2686592" "unprognostic (2.24e-1)" "unprognostic (1.74e-1)" "unprognostic (5.55e-2)" "unprognostic (1.83e-2)" "unprognostic (1.68e-1)" "unprognostic (1.26e-3)" "prognostic favorable (2.31e-5)" "unprognostic (7.48e-2)" "unprognostic (1.72e-2)" "unprognostic (1.41e-1)" "unprognostic (5.58e-2)" "unprognostic (2.72e-1)" "prognostic favorable (7.81e-4)" "unprognostic (7.50e-3)" "unprognostic (6.87e-3)" "unprognostic (1.83e-1)" "unprognostic (5.24e-3)" 20.1 9.1 8.1 5.8 7.0 0.2 14.0 6.1 8.4 9.3 4.3 5.0 3.7 12.4 2.3 5.3 6.7 11.2 16.8 7.1 6.8 23.0 10.5 28.8 3.7 7.2 6.6 3.5 3.5 4.4 3.0 46.3 7.6 3.8 5.4 0.7 3.1 6.2 10.5 2.8 5.5 12.7 6.8 28.8 4.0 1.4 9.4 1.8 9.1 22.9 2.8 6.9 3.9 6.8 0.3 0.0 3.5 0.0 0.4 5.6 0.1 3.2 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.0 2.4 0.0 1.6 0.0 0.0 1.8 0.0 2.2 0.8 0.1 90.9 0.0 0.0 0.0 0.7 0.0 0.0 0.0 45.2 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 18.3 0.0 0.0 99.1 0.0 0.5 9.1 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 8.1 7.0 6.1 8.4 7.1 6.8 7.2 6.6 7.6 6.8 9.4 6.8 70.8 3.2 1.3 1.3 0.4 1.5 0.0 0.0 0.0 0.0 0.3 0.5 8.6 0.0 0.6 1.8 0.0 0.4 0.4 0.0 0.0 0.0 0.6 0.6 0.8 73.9 0.0 2.7 4.3 0.0 2.8 4.2 0.0 0.7 0.0 0.3 122.0 1.3 0.3 0.0 5.0 0.0 0.0 6.7 2.2 0.9 0.6 0.4 0.0 38.4 0.0 0.1 0.0 137.7 2.1 1.3 0.0 0.4 0.0 0.2 0.0 0.1 0.0 0.2 0.0 1.6 1.9 0.1 0.4 0.3 1.3 1.4 0.5 1.8 0.0 0.0 TENT2 "FLJ38499, GLD2, PAPD4, TUT2" ENSG00000164329 "Terminal nucleotidyltransferase 2" Q6PIY7 5 79612120-79686648 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "mRNA processing" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "dendritic cells: 37.6;Glandular and luminal cells: 33.2;Granulosa cells: 31.9;Hofbauer cells: 33.9;Syncytiotrophoblasts: 33.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA054468 Approved Cytosol No No "Cluster 27: Non-specific - Gene expression" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 7: Non-specific - Mitochondria" Cytosol "HPA054468: AB_2682497" "unprognostic (1.52e-1)" "unprognostic (2.17e-1)" "unprognostic (6.25e-3)" "unprognostic (1.91e-1)" "unprognostic (8.03e-2)" "unprognostic (2.80e-3)" "unprognostic (2.10e-2)" "unprognostic (1.10e-1)" "unprognostic (6.80e-2)" "unprognostic (1.57e-3)" "unprognostic (9.37e-2)" "unprognostic (2.21e-1)" "unprognostic (7.71e-2)" "unprognostic (2.38e-1)" "unprognostic (8.43e-3)" "unprognostic (5.84e-3)" "unprognostic (2.67e-3)" 19.1 15.1 10.4 20.4 12.8 44.4 25.0 11.5 15.6 17.9 15.0 18.5 17.8 19.6 23.6 16.5 16.0 17.3 14.5 9.6 10.8 17.6 23.8 17.9 30.2 12.0 11.1 22.7 15.2 15.5 11.5 21.0 12.5 15.7 20.8 14.3 15.1 15.3 16.2 23.8 19.1 18.3 10.9 27.8 17.7 17.5 11.2 27.2 22.4 14.3 28.1 19.1 15.9 15.2 22.5 15.3 16.8 26.7 28.8 33.2 26.8 26.6 40.6 30.5 48.3 13.8 26.1 41.8 13.6 29.6 35.9 21.1 21.8 29.6 34.6 31.3 19.9 23.9 19.4 21.6 37.3 35.7 31.6 29.5 31.4 21.6 40.1 29.7 26.2 30.0 27.7 30.0 34.0 12.3 40.8 45.6 15.6 17.0 10.8 36.2 16.8 47.2 29.4 31.8 11.0 20.1 21.1 22.8 42.8 26.4 19.6 55.6 24.2 16.4 11.1 16.0 29.9 31.3 27.8 40.7 28.9 36.8 23.4 30.7 21.5 21.6 19.0 24.8 31.3 21.6 20.5 21.0 21.9 17.2 19.5 20.6 19.2 21.8 26.0 12.0 23.4 19.0 10.4 12.8 11.5 15.6 9.6 10.8 12.0 11.1 12.5 10.9 11.2 15.2 25.9 0.0 0.0 0.0 14.0 0.0 0.0 0.0 0.0 0.0 24.2 16.5 0.0 0.0 0.0 27.6 0.0 26.3 37.6 0.0 17.6 10.2 0.0 21.3 29.0 7.2 0.0 0.0 0.0 10.2 22.6 8.7 0.0 33.2 0.0 31.9 0.0 0.0 33.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.9 0.0 0.0 9.8 0.0 0.0 0.0 0.0 14.9 0.0 0.0 11.5 0.0 0.0 26.5 0.0 0.0 0.0 0.0 9.0 0.0 0.0 0.0 0.0 33.7 11.0 23.7 0.0 0.0 TENT4A "LAK-1, PAPD7, POLK, POLS, TRF4, TRF4-1" ENSG00000112941 "Terminal nucleotidyltransferase 4A" Q5XG87 5 6713432-6757044 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "mRNA processing" "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Adipocytes: 19.3;Breast glandular cells: 13.4;Breast myoepithelial cells: 13.2;dendritic cells: 12.3;Endometrial stromal cells: 15.4;Glandular and luminal cells: 14.0;Granulosa cells: 14.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045487, HPA046742" Enhanced Supported "Nucleoplasm,Nuclear membrane,Golgi apparatus" NA NA "Cluster 35: T-regs - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 20: HeLa - Mitochondria" "Cluster 65: Plasmacytoid DCs - Unknown function" Nucleoplasm "Nuclear membrane, Golgi apparatus" "HPA045487: AB_2679346, HPA046742: AB_2679781" "unprognostic (1.45e-1)" "unprognostic (2.96e-1)" "unprognostic (2.08e-2)" "unprognostic (2.12e-3)" "unprognostic (7.57e-2)" "unprognostic (1.30e-2)" "unprognostic (4.22e-2)" "unprognostic (2.37e-1)" "unprognostic (2.62e-1)" "unprognostic (9.78e-2)" "unprognostic (3.10e-3)" "unprognostic (3.73e-2)" "prognostic unfavorable (7.99e-5)" "unprognostic (6.56e-2)" "unprognostic (2.08e-1)" "unprognostic (2.60e-2)" "prognostic favorable (8.55e-4)" 13.1 8.1 8.4 9.5 8.6 27.6 11.0 16.6 10.1 12.5 5.7 10.0 8.7 11.1 6.4 10.7 11.5 10.0 8.5 8.7 8.1 9.6 20.5 12.8 13.0 6.5 6.5 15.6 12.0 10.0 11.1 9.1 7.0 11.1 7.2 12.5 8.2 8.8 9.3 15.7 12.4 12.2 6.0 13.7 9.6 10.1 7.9 14.6 10.2 12.1 10.4 10.1 11.8 8.9 31.7 20.9 25.4 31.6 17.7 15.6 37.0 21.0 25.7 25.1 28.2 21.9 17.3 23.1 16.1 25.5 28.5 22.9 20.7 16.4 23.1 26.1 14.0 12.0 72.5 12.4 11.0 18.0 17.3 10.7 13.8 28.7 18.4 18.6 15.0 16.9 16.3 29.8 20.8 17.6 24.4 25.3 13.6 9.7 16.6 21.8 21.2 6.0 10.5 17.5 25.1 19.3 50.7 24.1 14.5 13.4 14.5 9.9 13.6 30.6 32.7 27.2 29.8 28.6 12.6 20.4 19.6 16.4 19.2 0.0 0.2 0.2 0.6 0.1 0.6 0.5 0.4 0.4 0.3 0.4 0.5 0.5 0.1 0.1 0.2 1.1 0.6 0.2 8.4 8.6 16.6 10.1 8.7 8.1 6.5 6.5 7.0 6.0 7.9 8.9 19.3 0.0 0.0 0.0 7.3 0.0 0.0 0.0 0.0 0.0 13.4 13.2 0.0 0.0 0.0 5.5 0.0 5.3 12.3 0.0 1.9 4.9 0.0 10.7 15.4 4.8 0.0 0.0 0.0 4.4 4.0 4.0 0.0 14.0 0.0 14.5 0.0 0.0 6.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.8 0.0 0.0 4.2 0.0 0.0 0.0 0.0 6.6 0.0 0.0 8.4 0.0 0.0 2.5 0.0 0.0 0.0 0.0 6.2 0.0 0.0 0.0 0.0 5.6 4.8 10.7 0.0 0.0 TENT4B "PAPD5, TRF4-2, TUT3" ENSG00000121274 "Terminal nucleotidyltransferase 4B" Q8NDF8 16 50152911-50235310 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, mRNA processing, rRNA processing" "DNA-binding, DNA-directed DNA polymerase, Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "dendritic cells: 82.8;Endometrial ciliated cells: 44.3;Glandular and luminal cells: 31.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA042968, HPA048225" Uncertain Supported "Nucleoli,Plasma membrane,Cytosol" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 72: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 24: Non-specific - Transcription regulation" Cytosol "Nucleoli, Plasma membrane" "HPA042968: AB_2678244, HPA048225: AB_2680319" "unprognostic (1.05e-2)" "unprognostic (4.09e-2)" "unprognostic (1.77e-2)" "unprognostic (1.63e-1)" "unprognostic (3.27e-1)" "unprognostic (2.91e-2)" "unprognostic (4.33e-2)" "unprognostic (2.46e-1)" "unprognostic (7.83e-2)" "unprognostic (1.30e-1)" "unprognostic (1.30e-1)" "unprognostic (3.30e-2)" "prognostic favorable (1.85e-4)" "unprognostic (4.24e-2)" "unprognostic (1.06e-1)" "unprognostic (1.83e-1)" "unprognostic (7.00e-2)" 6.1 6.4 2.4 1.7 2.3 7.1 4.6 3.9 2.6 7.3 3.0 6.9 4.6 6.9 2.3 5.4 6.5 2.0 3.7 2.7 3.0 4.2 8.9 5.0 2.3 2.2 2.4 6.8 4.3 3.9 4.8 2.8 2.2 5.3 1.9 1.4 4.7 1.7 5.4 5.5 5.9 2.5 2.2 4.6 5.5 5.7 3.1 1.7 4.7 2.1 1.9 7.2 6.4 2.7 5.5 1.9 0.6 3.3 3.8 2.0 4.3 3.9 2.3 3.5 1.6 3.4 2.3 6.5 5.6 2.7 1.4 3.6 3.9 2.0 3.1 3.8 4.5 3.6 1.6 5.4 3.8 2.4 4.9 1.9 2.6 2.3 3.3 2.3 1.8 2.1 4.2 1.5 4.1 1.5 3.5 4.6 4.2 1.5 4.5 4.9 4.8 6.9 1.7 0.5 4.0 2.2 4.9 2.7 2.3 1.5 1.5 0.9 3.0 2.1 4.1 4.0 1.9 4.9 3.7 6.9 1.7 2.7 2.7 0.0 0.4 0.0 0.4 0.2 0.1 0.3 0.2 0.5 0.2 0.2 0.3 0.5 0.7 0.2 0.2 0.4 0.1 0.1 2.4 2.3 3.9 2.6 2.7 3.0 2.2 2.4 2.2 2.2 3.1 2.7 17.9 0.0 0.0 0.0 6.7 0.0 0.0 0.0 0.0 0.0 17.8 16.3 0.0 0.0 0.0 14.7 0.0 18.1 82.8 0.0 3.9 10.9 0.0 44.3 24.4 6.1 0.0 0.0 0.0 14.9 11.5 6.7 0.0 31.5 0.0 13.5 0.0 0.0 15.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.7 0.0 0.0 3.6 0.0 0.0 0.0 0.0 15.2 0.0 0.0 22.0 0.0 0.0 20.2 0.0 0.0 0.0 0.0 14.0 0.0 0.0 0.0 0.0 18.3 14.9 17.3 0.0 0.0 TENT5C "FAM46C, FLJ20202" ENSG00000183508 "Terminal nucleotidyltransferase 5C" Q5VWP2 1 117606048-117628389 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Host-virus interaction" "Nucleotidyltransferase, RNA-binding, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 89.1" "Cell type enhanced" "Detected in some" "B-cells: 41.8;Breast glandular cells: 34.0;Breast myoepithelial cells: 43.2;dendritic cells: 104.5;Plasma cells: 47.7;T-cells: 48.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Immune cell enhanced" "Detected in many" "basophil: 29.3" "Group enriched" "Detected in many" 17 "B-cells: 13.3;granulocytes: 29.3;T-cells: 13.7" "Cell line enhanced" "Detected in many" "Karpas-707: 296.2;RPMI-8226: 185.5;U-266/70: 81.7;U-266/84: 72.8" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA054049 Uncertain Supported Nucleoplasm NA NA "Cluster 46: Basophils - DNA binding" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 2: Karpas-707 - Immune response" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "HPA054049: AB_2682356" "unprognostic (3.76e-2)" "unprognostic (3.85e-3)" "unprognostic (3.24e-3)" "prognostic favorable (3.75e-5)" "unprognostic (1.17e-1)" "unprognostic (1.55e-3)" "unprognostic (3.29e-1)" "unprognostic (2.88e-2)" "unprognostic (5.75e-2)" "unprognostic (1.36e-3)" "unprognostic (9.41e-3)" "unprognostic (3.91e-2)" "prognostic favorable (2.77e-5)" "unprognostic (6.26e-2)" "unprognostic (3.16e-2)" "unprognostic (3.08e-2)" "unprognostic (1.10e-2)" 2.8 2.4 0.9 17.0 1.0 89.1 11.6 1.1 1.6 10.9 27.4 23.8 16.0 3.2 19.1 3.6 4.8 7.8 6.9 1.4 0.9 7.5 10.3 10.5 18.8 1.6 1.6 9.0 46.8 11.2 2.6 3.8 1.1 6.6 24.8 0.1 25.8 4.1 29.4 1.2 13.0 2.9 1.9 21.7 30.2 43.5 1.0 6.2 14.3 10.9 37.3 14.1 1.9 1.3 0.2 0.1 0.1 1.3 0.1 0.0 1.3 0.6 26.9 0.5 0.2 1.7 0.2 4.9 0.3 0.8 0.3 0.3 0.1 0.5 0.2 17.6 1.6 37.9 0.2 0.0 0.1 22.4 46.8 0.0 0.1 0.4 0.0 0.1 0.1 10.0 5.2 296.2 0.0 3.8 0.1 22.8 3.8 4.5 2.4 0.1 0.1 185.5 0.3 3.7 2.2 0.2 1.7 2.4 1.8 0.6 1.9 0.2 0.5 0.3 2.1 0.1 0.4 81.7 72.8 1.9 1.7 8.1 2.4 29.3 0.0 15.9 3.4 0.0 3.1 13.3 3.3 4.4 0.1 10.4 0.4 1.9 1.6 1.1 0.0 0.3 13.7 2.9 0.9 1.0 1.1 1.6 1.4 0.9 1.6 1.6 1.1 1.9 1.0 1.3 17.0 0.0 0.0 0.0 41.8 0.0 0.0 0.0 0.0 0.0 34.0 43.2 0.0 0.0 0.0 1.8 0.0 1.9 104.5 0.0 11.7 0.8 0.0 8.3 5.4 2.9 0.0 0.0 0.0 5.2 2.2 3.2 0.0 13.7 0.0 0.7 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.3 0.0 0.0 47.7 0.0 0.0 9.0 0.0 0.0 0.0 0.0 5.2 0.0 0.0 0.0 0.0 2.2 48.4 1.0 0.0 0.0 TENT5D "CT1.26, CT112, FAM46D, MGC26999" ENSG00000174016 "Terminal nucleotidyltransferase 5D" Q8NEK8 X 80335504-80445311 "Enzymes, Predicted intracellular proteins" "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 35 "testis: 3.4" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "AN3-CA: 1.1" "Not detected" "Not detected" "Not detected" "Not detected" HPA059362 Uncertain NA NA "Cluster 83: Testis - Spermatogenesis" "Cluster 23: AN3-CA - Transcription regulation" "HPA059362: AB_2683991" "unprognostic (3.49e-1)" "unprognostic (1.14e-2)" "unprognostic (4.36e-1)" "unprognostic (1.59e-1)" "unprognostic (4.64e-1)" "unprognostic (4.28e-2)" "unprognostic (8.21e-3)" "unprognostic (2.95e-3)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 TERT "EST2, hEST2, TCS1, TP2, TRT" ENSG00000164362 "Telomerase reverse transcriptase" O14746 5 1253147-1295068 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted membrane proteins" "DNA-binding, Nucleotidyltransferase, Ribonucleoprotein, RNA-directed DNA polymerase, Transferase" "Cancer-related genes, Disease variant, Dyskeratosis congenita" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 1.4;Intestinal goblet cells: 1.0;Plasma cells: 2.8;Spermatocytes: 1.5;Spermatogonia: 4.1" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "ASC TERT1: 438.0;fHDF/TERT166: 429.4;HBEC3-KT: 929.2;hTEC/SVTERT24-B: 560.1;LHCN-M2: 252.2;TIME: 799.9" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA054641, HPA065897" Supported Supported "Nucleoplasm,Nuclear speckles,Cytosol" NA NA "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 55: Plasma cells - Humoral immune response" Nucleoplasm "Nuclear speckles, Cytosol" "HPA054641: AB_2682554, HPA065897: AB_2685576" "unprognostic (1.21e-2)" "unprognostic (2.88e-2)" "unprognostic (1.24e-3)" "unprognostic (1.53e-1)" "unprognostic (1.43e-3)" "unprognostic (6.42e-3)" "unprognostic (1.85e-2)" "unprognostic (2.21e-1)" "unprognostic (6.91e-2)" "unprognostic (1.89e-1)" "unprognostic (3.59e-1)" "unprognostic (9.16e-4)" "unprognostic (8.84e-11)" "unprognostic (1.92e-1)" "unprognostic (2.15e-1)" "unprognostic (3.35e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.5 213.2 438.0 3.2 0.0 173.9 31.7 59.4 0.3 0.1 3.0 0.2 429.4 0.1 0.1 1.0 929.2 29.1 0.0 1.7 0.1 0.0 0.4 0.1 0.5 1.2 0.0 22.9 560.1 6.8 1.3 1.5 1.8 2.9 0.2 252.2 0.4 0.2 9.4 2.9 0.1 1.3 2.1 0.0 5.4 23.9 0.5 0.2 2.1 0.1 0.0 0.2 0.0 0.1 0.3 799.9 0.0 0.0 0.0 0.0 0.9 0.5 0.7 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.0 0.0 0.0 0.0 0.0 0.1 0.1 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 4.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 TESK1 ENSG00000107140 "Testis associated actin remodelling kinase 1" Q15569 9 35605262-35610041 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 40: NK-cells - Unknown function" "Cluster 47: Non-specific - Unknown function" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 41: Macrophages - Immune response" "unprognostic (5.17e-2)" "unprognostic (2.82e-1)" "unprognostic (4.96e-3)" "unprognostic (5.18e-2)" "unprognostic (2.04e-2)" "unprognostic (8.76e-2)" "prognostic unfavorable (9.68e-4)" "unprognostic (1.82e-2)" "unprognostic (1.24e-1)" "unprognostic (2.66e-3)" "unprognostic (1.22e-2)" "unprognostic (2.56e-1)" "unprognostic (5.57e-2)" "unprognostic (1.74e-2)" "unprognostic (2.34e-1)" "unprognostic (1.43e-2)" "unprognostic (1.25e-3)" 40.2 44.7 24.4 11.2 22.0 6.1 33.5 17.9 25.9 22.6 14.8 29.9 13.3 25.7 11.1 12.8 18.7 13.0 19.2 22.0 21.3 18.0 13.8 19.9 11.9 20.6 24.2 15.9 16.0 16.8 26.6 9.1 21.8 22.4 8.5 6.7 17.4 19.8 69.2 19.1 18.9 17.1 18.2 16.2 22.2 57.0 28.1 10.4 19.0 27.6 8.5 27.9 16.0 20.4 17.0 16.0 10.7 16.9 42.5 17.5 12.1 19.7 17.3 17.8 11.3 9.3 4.8 30.9 10.3 19.7 47.1 5.8 6.8 14.1 3.4 20.0 9.2 4.6 14.1 8.4 24.4 4.0 14.6 17.2 21.8 13.9 19.0 18.9 12.6 15.3 5.3 11.3 18.0 19.1 7.9 18.4 6.2 16.1 18.6 12.9 6.6 7.3 13.1 8.0 8.8 10.3 11.2 13.0 8.1 7.3 15.9 5.7 11.1 39.2 16.2 27.9 12.0 6.0 10.2 11.2 28.2 4.6 9.1 0.0 0.6 0.1 1.1 0.1 1.0 0.3 0.4 1.8 0.8 0.2 0.5 0.5 0.0 0.9 0.3 0.8 0.1 0.7 24.4 22.0 17.9 25.9 22.0 21.3 20.6 24.2 21.8 18.2 28.1 20.4 13.4 6.4 7.7 9.1 8.9 14.4 6.3 5.9 4.6 10.9 13.9 11.0 1.9 7.2 4.2 7.3 8.4 3.8 20.0 19.9 1.9 6.6 35.1 5.6 9.2 9.7 9.5 1.7 6.5 10.4 8.6 9.0 18.8 11.2 1.3 10.1 10.8 8.4 13.9 13.5 8.5 14.8 0.0 7.8 22.4 34.9 12.2 19.3 14.2 2.8 6.3 12.6 20.6 4.5 6.8 10.2 11.0 14.3 10.7 19.2 13.4 7.8 4.2 15.3 6.6 10.1 10.9 14.8 10.0 4.7 13.9 3.3 11.8 5.4 7.3 9.7 TESK2 ENSG00000070759 "Testis associated actin remodelling kinase 2" Q96S53 1 45343883-45491163 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in many" 4 "Oligodendrocytes: 222.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "BEWO: 14.6;RT4: 14.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027257, HPA063869" Uncertain Enhanced Nucleoplasm NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 2: Karpas-707 - Immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Nucleoplasm "HPA027257: AB_10602477, HPA063869: AB_2685137" "unprognostic (2.95e-1)" "prognostic favorable (2.22e-4)" "unprognostic (3.90e-2)" "unprognostic (5.04e-3)" "unprognostic (6.03e-2)" "unprognostic (1.87e-3)" "unprognostic (3.22e-2)" "unprognostic (1.43e-2)" "unprognostic (5.15e-2)" "unprognostic (2.96e-1)" "unprognostic (2.28e-1)" "unprognostic (2.86e-1)" "unprognostic (4.36e-2)" "unprognostic (2.49e-2)" "unprognostic (1.13e-1)" "unprognostic (4.37e-2)" "unprognostic (2.01e-1)" 3.8 2.1 7.1 2.8 10.6 10.2 6.6 10.3 8.3 6.4 4.8 5.3 8.6 3.2 3.7 7.1 3.0 2.6 2.4 7.3 8.0 2.5 6.9 3.9 3.9 10.8 10.1 9.8 3.6 3.4 2.4 3.5 10.3 15.5 7.0 2.8 8.4 2.6 8.3 12.7 10.8 2.9 8.5 5.3 4.5 9.6 9.9 4.2 3.4 4.7 5.2 4.7 7.4 15.1 1.9 0.0 0.9 0.1 3.5 1.8 14.6 0.7 4.9 2.1 3.6 4.3 1.7 6.2 0.6 1.8 5.4 2.3 3.9 3.1 1.6 4.4 4.9 4.2 2.0 3.2 1.9 1.4 11.1 1.9 3.2 2.4 3.4 3.2 1.7 8.1 0.8 12.4 1.4 0.7 3.6 2.9 3.8 1.8 1.8 5.2 0.1 1.5 1.9 14.7 0.4 1.6 3.8 7.3 14.1 8.6 11.3 1.8 0.0 0.2 2.1 1.3 1.3 8.0 5.0 1.2 1.1 0.0 1.0 12.8 4.6 13.3 2.7 3.4 1.9 8.0 2.5 1.8 2.4 6.6 4.1 2.3 19.0 1.5 8.0 1.3 1.9 3.4 7.1 10.6 10.3 8.3 7.3 8.0 10.8 10.1 10.3 8.5 9.9 15.1 3.9 0.0 2.8 54.2 10.7 7.8 7.1 2.8 14.2 2.4 11.9 9.4 1.3 4.3 3.4 0.0 14.6 8.3 4.2 13.9 0.0 1.3 23.7 4.6 1.8 3.2 4.2 5.0 10.2 2.7 2.8 3.7 7.7 8.9 7.0 2.4 2.2 6.3 6.8 0.0 6.7 6.9 4.1 5.5 4.4 7.8 2.8 6.0 3.6 15.9 4.6 1.1 4.1 18.6 222.9 1.1 7.3 1.9 9.8 10.6 14.9 1.2 2.0 3.1 6.6 2.6 6.1 22.0 13.6 12.6 8.5 14.8 4.7 1.8 4.9 8.0 TGFBR1 "ACVRLK4, ALK-5, ALK5, ESS1, MSSE, TBR-i, TBRI" ENSG00000106799 "Transforming growth factor beta receptor 1" P36897 9 99104038-99154192 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Apoptosis, Differentiation, Growth regulation" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Aortic aneurysm, Craniosynostosis, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 128.4;Late spermatids: 101.7;Microglial cells: 116.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "RH-30: 253.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002441, CAB031481, HPA056473" Uncertain Supported "Plasma membrane" "Intracellular and membrane" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 65: Plasmacytoid DCs - Unknown function" "Plasma membrane" "CAB002441: AB_564029, CAB031481: AB_2202455, HPA056473: AB_2683144" "unprognostic (2.58e-3)" "unprognostic (1.20e-2)" "unprognostic (3.64e-3)" "unprognostic (2.80e-1)" "unprognostic (8.63e-2)" "unprognostic (3.36e-2)" "unprognostic (1.97e-2)" "unprognostic (1.32e-3)" "unprognostic (1.97e-1)" "unprognostic (1.45e-1)" "unprognostic (8.21e-3)" "unprognostic (1.82e-1)" "unprognostic (1.18e-1)" "unprognostic (1.01e-3)" "unprognostic (3.40e-2)" "unprognostic (3.19e-2)" "unprognostic (1.14e-2)" 15.9 9.9 9.8 18.2 9.3 33.7 15.4 13.2 8.9 19.4 11.8 18.8 11.7 20.6 8.8 15.0 8.5 21.7 8.2 6.8 11.3 22.6 14.8 16.3 13.8 18.4 14.5 13.0 8.3 8.5 7.6 48.8 20.0 17.1 13.4 4.7 8.3 16.8 8.7 6.2 9.3 33.0 18.0 16.5 18.4 18.3 17.5 11.2 11.2 13.2 13.6 22.5 8.4 27.9 13.7 19.5 115.5 36.1 26.2 19.3 17.4 44.1 47.8 40.7 44.9 19.9 9.3 29.7 13.4 34.6 32.1 30.4 39.6 34.1 54.0 77.1 12.3 43.9 20.7 17.8 43.2 27.2 102.8 40.2 35.4 62.8 29.5 25.2 7.4 10.9 62.4 12.1 55.4 20.3 4.0 31.0 24.7 12.2 11.5 11.0 253.1 12.5 9.9 3.8 31.1 36.2 34.3 150.2 46.4 47.3 28.1 36.6 13.6 29.8 25.5 129.3 27.3 12.1 13.4 20.0 62.5 45.9 26.2 16.2 2.4 9.5 7.8 1.6 6.7 1.6 3.3 5.8 2.0 1.2 3.2 6.2 4.9 4.3 2.0 1.4 2.4 2.2 9.8 9.3 13.2 8.9 6.8 11.3 18.4 14.5 20.0 18.0 17.5 27.9 13.5 6.4 8.8 18.9 18.9 23.6 7.4 19.9 44.3 8.0 18.9 11.7 7.6 4.3 12.8 60.7 0.0 23.0 37.3 5.0 0.0 18.8 128.4 6.4 22.7 17.6 9.6 7.4 14.2 31.2 6.7 36.0 9.2 9.3 29.9 19.5 6.4 12.7 49.4 0.0 8.6 7.3 8.2 32.4 52.5 101.7 9.6 39.7 35.6 116.2 24.3 3.1 35.0 45.8 21.1 33.8 4.2 13.5 11.9 18.4 3.6 13.8 5.0 2.0 32.9 21.8 20.9 11.0 12.7 25.6 16.2 19.4 25.4 7.6 8.3 11.5 TGFBR2 "MFS2, TBR-ii, TBRII" ENSG00000163513 "Transforming growth factor beta receptor 2" P37173 3 30606601-30694142 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted membrane proteins" "Apoptosis, Differentiation, Growth regulation" "Kinase, Receptor, Serine/threonine-protein kinase, Transferase" "Aortic aneurysm, Cancer-related genes, Craniosynostosis, Disease variant, FDA approved drug targets, Hereditary nonpolyposis colorectal cancer" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Adipocytes: 391.5;Endothelial cells: 236.4;Hepatic stellate cells: 478.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "ASC diff: 313.6;ASC TERT1: 472.3;HSkMC: 430.0;LHCN-M2: 381.7;TIME: 418.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB073537 Supported "Plasma membrane" NA NA 810000 "Cluster 5: Granulocytes - Unknown function" "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Plasma membrane" "CAB073537: " "unprognostic (1.74e-1)" "unprognostic (1.84e-2)" "unprognostic (3.70e-1)" "unprognostic (3.02e-2)" "unprognostic (1.92e-1)" "unprognostic (2.26e-1)" "unprognostic (1.96e-1)" "unprognostic (1.62e-1)" "unprognostic (1.40e-1)" "unprognostic (2.24e-2)" "unprognostic (7.36e-2)" "unprognostic (1.12e-1)" "unprognostic (1.65e-2)" "unprognostic (4.72e-2)" "unprognostic (1.81e-2)" "unprognostic (8.81e-2)" "unprognostic (8.02e-2)" 230.0 56.1 16.5 73.8 12.9 29.4 145.7 13.8 19.3 90.0 30.6 96.0 44.2 69.1 18.2 44.9 69.6 91.9 95.2 10.6 13.4 67.9 59.1 148.0 70.1 17.6 16.5 26.6 52.0 59.0 16.9 81.6 16.7 44.1 54.1 2.1 49.2 60.8 31.1 39.1 77.7 107.2 17.3 111.1 63.4 7.8 21.5 49.7 91.8 62.2 60.7 98.0 55.1 17.2 16.6 100.2 5.3 0.1 313.6 472.3 15.9 83.9 116.1 28.5 27.7 22.9 86.6 2.2 298.2 117.2 32.2 33.3 4.0 125.4 42.0 7.0 8.9 10.1 10.7 104.5 128.5 14.9 76.6 430.0 93.6 126.3 114.4 117.0 296.0 10.9 1.8 0.0 381.7 1.3 16.2 10.5 2.2 75.7 39.8 14.1 36.4 2.1 113.5 40.5 0.1 5.6 24.9 6.1 22.0 6.6 0.0 14.0 418.6 134.7 33.2 61.4 32.0 2.8 0.3 12.5 80.1 16.1 55.8 9.0 3.0 11.5 3.4 3.1 3.3 4.5 4.8 3.3 2.6 6.4 16.6 7.3 13.1 1.9 8.0 6.6 0.7 3.8 16.5 12.9 13.8 19.3 10.6 13.4 17.6 16.5 16.7 17.3 21.5 17.2 391.5 144.2 99.7 0.7 77.0 37.3 18.9 23.5 39.9 5.1 23.7 24.1 84.5 50.1 39.5 27.6 0.0 6.8 85.3 10.5 3.9 13.1 2.5 28.3 57.5 236.4 8.4 20.4 0.4 15.8 5.1 129.2 39.3 30.8 29.8 0.7 478.0 55.5 30.4 0.0 1.0 12.4 22.4 147.0 58.0 3.8 32.9 67.9 30.2 170.5 47.5 0.2 56.7 6.0 2.4 37.6 12.1 47.4 37.5 8.6 13.6 7.2 14.7 1.2 32.9 60.8 53.4 0.3 1.2 8.0 30.5 3.7 68.2 1.7 14.5 10.8 TGM1 "ICR2, LI, LI1, TGASE, TGK" ENSG00000092295 "Transglutaminase 1" P22735 14 24249114-24264432 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Keratinization "Acyltransferase, Transferase" "Disease variant, Ichthyosis" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "esophagus: 713.5" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 12.8;Basal respiratory cells: 63.6;Club cells: 18.8;Distal tubular cells: 29.4;Squamous epithelial cells: 34.7" "Group enriched" "Detected in many" 4 "cervical cancer: 30.8;head and neck cancer: 78.3" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "BEWO: 17.5;HaCaT: 24.2;HeLa: 16.2;MCF7: 17.5;SK-BR-3: 21.7" "Not detected" "Not detected" "Low region specificity" "Detected in all" "CAB015159, HPA040171, HPA070372" Enhanced Approved "Vesicles,Plasma membrane" NA NA 530000 "Cluster 84: Esophagus - Epithelial cell function" "Cluster 28: BEWO - Transcription regulation" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "Vesicles, Plasma membrane" "CAB015159: AB_2202870, HPA040171: AB_2676869, HPA070372: " "unprognostic (2.95e-2)" "unprognostic (8.79e-2)" "unprognostic (2.92e-2)" "unprognostic (1.89e-2)" "unprognostic (2.36e-1)" "unprognostic (1.10e-1)" "unprognostic (4.04e-2)" "unprognostic (1.12e-2)" "unprognostic (2.39e-1)" "unprognostic (3.01e-2)" "unprognostic (6.72e-2)" "unprognostic (2.15e-1)" "unprognostic (1.94e-7)" "unprognostic (7.11e-2)" "unprognostic (7.38e-2)" "unprognostic (2.22e-3)" "unprognostic (1.86e-2)" 25.7 1.3 0.6 0.9 0.8 0.7 2.2 3.7 2.0 78.7 0.8 1.4 0.8 1.0 1.6 713.5 4.4 0.6 5.1 0.5 0.6 2.5 1.7 5.3 1.5 1.5 0.9 3.0 3.2 0.2 3.3 1.2 1.4 4.1 0.9 1.7 89.7 4.4 1.1 73.2 1.9 0.5 0.4 2.6 1.8 2.9 0.9 1.3 2.7 0.3 40.4 1.3 144.2 0.9 1.1 2.0 1.1 1.0 0.0 0.8 17.5 0.4 0.2 1.0 1.6 1.2 1.7 1.0 2.3 1.3 0.3 24.2 2.8 2.0 0.6 2.0 3.3 1.4 16.2 5.7 0.8 0.9 1.5 1.5 9.3 0.5 2.0 0.5 0.7 3.4 1.0 1.0 0.7 17.5 0.7 1.9 0.3 1.1 2.2 1.1 0.1 1.1 0.6 2.1 1.2 1.6 0.2 21.7 0.1 1.4 1.5 1.1 0.8 1.1 4.8 2.0 0.9 1.5 1.8 0.3 0.4 2.1 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.8 3.7 2.0 0.5 0.6 1.5 0.9 1.4 0.4 0.9 0.9 0.2 12.8 1.1 2.0 0.0 0.3 4.6 63.6 4.0 0.9 1.1 0.8 0.8 5.7 18.8 0.0 0.0 1.4 0.3 0.2 29.4 2.0 0.1 0.3 0.2 0.2 0.0 0.0 1.5 0.9 0.8 3.9 0.0 0.6 4.5 0.7 0.0 0.2 0.4 0.0 1.7 0.1 6.1 0.6 0.3 0.0 0.6 0.4 0.0 1.0 0.4 0.2 0.0 1.0 1.0 2.6 0.0 0.4 0.1 7.4 0.1 0.2 2.1 0.6 0.0 0.1 1.0 0.0 0.6 34.7 1.8 1.2 0.6 1.2 0.3 6.2 TGM2 TGC ENSG00000198959 "Transglutaminase 2" P21980 20 38127385-38166578 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Acyltransferase, Hydrolase, Protease, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "cervix: 432.0" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 204.5;Cytotrophoblasts: 311.1;Ductal cells: 226.7;Endometrial stromal cells: 459.1;Hepatic stellate cells: 408.0;Hepatocytes: 205.7;Pancreatic endocrine cells: 326.5;Syncytiotrophoblasts: 374.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in many" 4 "CAPAN-2: 1546.7;EFO-21: 505.5;hTERT-RPE1: 994.3;HUVEC TERT2: 695.3;TIME: 924.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB002598, HPA021019, HPA029518" Enhanced Approved "Plasma membrane,Cytosol" "Secreted to extracellular matrix" Yes No 1700000 "Cluster 43: B-cells - Humoral immune response" "Cluster 46: Fibroblasts - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 36: Stromal cells - Cell proliferation" Cytosol "Plasma membrane" "CAB002598: , HPA021019: AB_1858247, HPA029518: AB_10603133" "unprognostic (7.80e-2)" "unprognostic (1.51e-1)" "unprognostic (5.22e-2)" "unprognostic (1.40e-2)" "unprognostic (1.56e-2)" "unprognostic (5.61e-3)" "unprognostic (2.81e-1)" "unprognostic (3.32e-3)" "unprognostic (3.29e-2)" "unprognostic (9.78e-3)" "prognostic unfavorable (2.97e-4)" "unprognostic (6.99e-2)" "prognostic unfavorable (1.67e-7)" "unprognostic (1.60e-2)" "unprognostic (1.93e-2)" "unprognostic (6.70e-2)" "unprognostic (6.40e-2)" 105.9 45.1 23.0 68.4 22.3 3.2 30.3 22.9 29.5 432.0 53.0 30.6 29.8 266.3 28.3 37.3 217.7 127.7 394.9 21.4 23.0 76.7 244.1 288.5 18.0 25.4 22.5 40.6 25.6 19.3 95.9 234.3 26.0 88.7 20.8 2.1 9.8 56.6 63.9 4.0 63.7 159.0 24.4 32.7 62.3 3.9 30.6 15.4 36.3 33.4 10.3 154.2 87.8 24.8 65.0 47.5 0.2 1.8 47.3 5.1 24.0 95.5 45.2 0.7 1.8 78.4 1546.7 0.1 505.5 1.0 105.4 1.7 0.1 221.7 3.4 0.7 0.2 10.3 2.6 35.0 191.9 0.0 0.5 5.2 0.4 40.2 0.3 994.3 695.3 0.0 21.4 0.1 16.0 0.3 0.0 0.6 0.8 0.9 4.6 0.0 0.1 0.3 69.0 0.0 0.0 1.3 224.4 0.2 7.6 31.6 2.2 0.6 924.2 1.6 57.6 7.8 46.3 0.0 0.6 0.8 60.7 0.1 18.4 0.0 0.0 0.0 0.0 0.6 0.0 0.4 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 23.0 22.3 22.9 29.5 21.4 23.0 25.4 22.5 26.0 24.4 30.6 24.8 58.0 9.6 18.3 0.0 7.4 0.5 10.4 41.0 0.6 0.0 8.5 8.8 204.5 31.5 55.3 14.7 2.1 311.1 0.1 11.7 3.9 226.7 3.2 16.7 459.1 183.8 0.0 74.5 0.1 145.7 38.6 37.7 0.5 13.1 2.5 2.8 408.0 205.7 54.4 0.0 0.1 1.8 6.1 23.7 2.1 5.0 1.2 35.5 0.0 28.1 6.5 0.4 0.0 0.0 0.3 326.5 1.1 6.0 0.0 68.6 63.0 27.6 23.6 0.5 0.0 5.2 49.1 0.4 4.0 0.9 0.0 374.2 3.9 2.1 3.3 26.4 TGM3 TGE ENSG00000125780 "Transglutaminase 3" Q08188 20 2296001-2341079 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Keratinization "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 8 "esophagus: 1838.1" "Group enriched" "Detected in some" 4 "Enteroendocrine cells: 46.2;Squamous epithelial cells: 22.5" "Cancer enriched" "Detected in many" 9 "head and neck cancer: 81.6" "Not detected" "Not detected" "Immune cell enriched" "Detected in single" 295 "neutrophil: 30.3" "Lineage enriched" "Detected in single" 303 "granulocytes: 30.3" "Cell line enriched" "Detected in single" 14 "EFO-21: 5.2" HPA004728 Approved NA NA 14000000 "Cluster 9: Neutrophils - Innate immune response" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 38: EFO-21 - Unknown function" "Cluster 61: Squamous epithelial cells - Keratinization" "HPA004728: AB_1080360" "unprognostic (7.14e-2)" "unprognostic (8.93e-2)" "unprognostic (2.18e-2)" "unprognostic (3.23e-3)" "unprognostic (4.27e-2)" "unprognostic (4.20e-2)" "unprognostic (8.62e-2)" "unprognostic (4.21e-2)" "unprognostic (1.50e-1)" "unprognostic (8.00e-2)" "unprognostic (4.88e-3)" "unprognostic (1.35e-1)" "unprognostic (7.78e-8)" "unprognostic (1.56e-1)" "unprognostic (1.61e-1)" "unprognostic (1.45e-2)" "unprognostic (9.67e-2)" 0.6 0.3 0.2 0.2 0.0 1.4 3.9 0.0 0.1 54.3 0.0 0.3 0.0 0.2 0.8 1838.1 1.4 2.2 0.4 0.2 0.0 0.2 0.8 0.5 0.0 0.1 0.3 0.3 1.1 0.0 1.6 0.1 0.1 0.6 0.8 0.0 229.3 0.0 0.4 83.1 0.4 0.0 0.1 0.4 2.2 2.0 0.0 0.1 0.1 0.0 142.9 0.3 31.4 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 5.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 30.3 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.2 0.0 0.1 0.3 0.1 0.1 0.0 0.0 0.0 0.0 0.6 0.3 0.0 1.7 0.0 0.0 0.0 0.0 0.4 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.1 1.9 4.0 0.1 0.1 46.2 0.0 0.4 0.0 0.0 0.3 0.0 0.2 0.0 0.9 0.0 0.0 0.0 0.0 0.2 3.7 0.0 0.0 0.3 4.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.3 0.0 0.0 3.2 0.0 0.0 0.0 0.1 1.2 0.5 22.5 8.2 0.0 0.0 0.1 0.3 0.2 TGM4 TGP ENSG00000163810 "Transglutaminase 4" P49221 3 44874608-44914990 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 377 "prostate: 434.4" "Cell type enriched" "Detected in some" 20 "Prostatic glandular cells: 226.6" "Cancer enriched" "Detected in single" 312 "prostate cancer: 75.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 4.9;hTERT-HME1: 1.3;NB-4: 2.7;RPMI-8226: 2.0;SH-SY5Y: 1.4" "Not detected" "Not detected" "CAB033571, HPA073290" Enhanced NA NA "Cluster 51: Non-specific - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 35: Glandular cells - Unknown function" "CAB033571: AB_2287329, HPA073290: " "unprognostic (4.40e-2)" "unprognostic (4.68e-2)" "unprognostic (1.92e-1)" "unprognostic (2.17e-3)" "unprognostic (2.84e-1)" "unprognostic (2.19e-2)" "unprognostic (1.37e-1)" "unprognostic (1.92e-1)" "unprognostic (2.41e-2)" "unprognostic (1.65e-1)" "unprognostic (8.56e-3)" "unprognostic (5.08e-2)" "unprognostic (1.44e-8)" "unprognostic (1.10e-1)" "unprognostic (1.98e-2)" "unprognostic (3.68e-1)" "unprognostic (6.41e-2)" 0.0 1.1 0.0 0.2 0.0 0.5 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 434.4 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 4.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.2 0.0 1.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.7 0.0 0.0 0.1 0.0 0.0 2.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.8 0.3 0.0 0.3 0.3 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.4 0.5 4.2 0.7 0.0 0.0 0.1 0.1 0.9 0.0 0.2 0.0 0.0 0.5 0.2 0.1 0.0 0.0 5.7 0.8 0.6 0.4 0.0 0.0 0.2 0.0 0.3 1.3 0.0 1.5 0.0 0.0 0.4 0.0 0.1 0.0 0.3 0.2 0.0 0.0 0.0 11.2 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.5 0.1 0.2 0.0 0.4 0.0 226.6 0.0 0.0 0.0 0.0 0.0 1.0 0.3 0.1 0.3 0.0 0.4 1.0 0.2 0.1 0.2 2.4 TGM5 "TGMX, TGX" ENSG00000104055 "Transglutaminase 5" O43548 15 43232590-43266928 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Acyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "esophagus: 12.0;skin 1: 39.3" "Cell type enhanced" "Detected in some" "Basal prostatic cells: 2.6;Club cells: 4.3;Early spermatids: 3.2;Late spermatids: 4.0;Suprabasal keratinocytes: 6.7;Urothelial cells: 12.1" "Cancer enhanced" "Detected in many" "head and neck cancer: 2.2" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 7 "HEL: 16.6" "Region enriched" "Detected in single" 12 "cerebellum: 2.6" "Low region specificity" "Detected in many" NA NA "Cluster 31: Skin - Epidermis development" "Cluster 36: HEL - Hemostasis" "Cluster 22: Epithelial cell types - Mixed function" "unprognostic (3.17e-2)" "unprognostic (1.03e-2)" "unprognostic (5.92e-2)" "unprognostic (2.65e-1)" "unprognostic (2.24e-2)" "unprognostic (1.94e-2)" "unprognostic (1.78e-1)" "unprognostic (7.68e-2)" "unprognostic (2.25e-2)" "unprognostic (1.77e-1)" "unprognostic (1.44e-15)" "unprognostic (1.94e-1)" "unprognostic (3.14e-1)" "unprognostic (7.22e-3)" "unprognostic (5.71e-2)" 0.8 0.0 0.0 0.0 0.0 0.2 1.7 0.2 0.0 3.9 0.0 0.0 0.0 0.0 0.0 12.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.2 0.0 0.0 0.0 0.1 0.0 0.2 1.0 0.0 0.0 4.3 1.2 0.3 39.3 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.2 0.0 0.0 2.3 0.5 7.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 16.6 0.0 0.3 0.0 0.7 2.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.0 0.1 0.0 2.4 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 0.4 0.2 0.2 0.3 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.9 2.6 1.5 0.0 0.0 1.0 0.5 0.2 0.0 4.3 0.0 0.0 0.1 0.0 0.0 0.0 0.1 3.2 0.4 0.1 0.1 0.0 0.0 0.1 0.0 0.0 0.2 0.0 1.3 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.4 4.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 2.1 0.0 0.0 0.3 0.0 0.0 0.0 0.2 0.1 0.2 0.8 6.7 1.9 0.0 0.0 0.0 12.1 TGM6 "dJ734P14.3, SCA35, TGM3L, TGY" ENSG00000166948 "Transglutaminase 6" O95932 20 2380901-2432753 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Acyltransferase, Transferase" "Disease variant, Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enriched" "Detected in single" 10 "cerebellum: 1.0" HPA059196 Uncertain NA NA "HPA059196: AB_2683943" "unprognostic (1.18e-1)" "unprognostic (2.84e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 TGM7 TGMZ ENSG00000159495 "Transglutaminase 7" Q96PF1 15 43276271-43302255 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Acyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in single" "lymphoid tissue: 1.6" "Group enriched" "Detected in some" 11 "Early spermatids: 62.0;Late spermatids: 16.7" "Cancer enriched" "Detected in single" 13 "endometrial cancer: 2.1" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 35 "EFO-21: 3.5" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 16: Immune cells - Immune response" "Cluster 38: EFO-21 - Unknown function" "Cluster 29: Early spermatids - Spermatogenesis" "unprognostic (2.45e-2)" "unprognostic (2.04e-1)" "unprognostic (2.82e-2)" "unprognostic (1.71e-2)" "unprognostic (1.07e-1)" "unprognostic (2.01e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 1.6 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.1 0.0 0.0 0.4 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 62.0 0.3 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 16.7 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.8 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.4 0.6 0.0 0.0 0.0 0.0 0.0 0.0 3.5 THG1L "FLJ11601, FLJ20546, hTHG1, ICF45, IHG-1" ENSG00000113272 "TRNA-histidine guanylyltransferase 1 like" Q9NWX6 5 157731420-157741449 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "tRNA processing" "Nucleotidyltransferase, Transferase" "Disease variant, Neurodegeneration" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035877, HPA035878" Approved NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 89: Fibroblasts - ECM organization" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 32: Non-specific - Translation" "HPA035877: AB_10669979, HPA035878: AB_10672993" "unprognostic (4.30e-3)" "unprognostic (2.64e-1)" "unprognostic (3.99e-3)" "unprognostic (2.86e-2)" "unprognostic (1.74e-1)" "unprognostic (4.37e-2)" "unprognostic (5.74e-3)" "unprognostic (4.08e-2)" "unprognostic (1.72e-1)" "unprognostic (7.16e-2)" "unprognostic (1.34e-1)" "unprognostic (4.05e-1)" "prognostic unfavorable (3.93e-6)" "unprognostic (1.48e-1)" "unprognostic (1.47e-1)" "unprognostic (3.09e-1)" "unprognostic (1.69e-1)" 3.8 4.9 2.3 4.0 2.5 5.9 5.3 2.7 2.7 5.2 2.2 6.9 5.5 6.8 5.9 5.0 6.4 4.7 3.4 2.2 2.7 3.5 5.1 3.0 5.4 2.6 2.4 7.6 4.7 3.1 3.2 4.3 2.6 4.0 7.7 3.4 3.1 5.3 3.9 5.4 4.9 5.7 2.1 4.1 5.4 4.9 2.6 5.3 6.7 2.8 6.0 6.4 4.6 3.0 8.8 15.4 7.2 13.8 6.7 19.6 5.5 6.8 12.6 13.7 18.1 21.4 8.7 21.8 5.7 6.0 8.3 9.1 9.0 13.1 15.2 8.9 12.0 7.7 10.2 9.1 7.6 16.6 8.0 17.8 15.4 12.1 16.6 13.0 5.1 3.4 13.8 6.9 8.2 12.1 2.0 11.3 6.9 3.9 14.8 3.3 13.8 12.6 8.5 11.0 9.1 12.8 5.5 8.2 11.3 5.2 13.9 9.5 5.8 10.9 7.2 9.2 18.5 6.0 7.1 14.0 4.8 15.9 6.9 3.9 7.8 0.1 3.3 8.7 3.9 5.7 4.3 3.4 7.0 4.6 6.3 5.3 0.7 6.7 8.7 4.5 5.0 3.9 2.3 2.5 2.7 2.7 2.2 2.7 2.6 2.4 2.6 2.1 2.6 3.0 6.0 3.2 8.6 1.3 14.7 20.6 27.7 27.1 27.9 2.6 14.2 15.4 6.2 11.5 11.5 3.7 4.2 17.6 10.2 6.9 9.8 17.1 19.2 8.8 20.8 9.0 7.2 23.5 1.8 26.4 12.8 15.4 12.2 7.2 2.5 17.3 6.8 8.6 19.1 0.0 1.4 14.3 8.2 15.7 17.9 8.6 14.3 16.2 5.4 1.9 21.2 2.0 7.2 0.5 1.9 12.1 19.6 15.4 13.7 21.2 9.7 14.7 5.8 4.6 6.6 17.1 12.4 19.8 8.9 24.0 15.3 13.8 11.2 38.0 24.1 28.4 TIE1 "JTK14, TIE" ENSG00000066056 "Tyrosine kinase with immunoglobulin like and EGF like domains 1" P35590 1 43300982-43323108 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" Angiogenesis "Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Group enriched" "Detected in many" 4 "Adipocytes: 130.8;Endothelial cells: 108.8;Hepatic stellate cells: 128.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 24 "basophil: 2.1;NK-cell: 2.5" "Group enriched" "Detected in many" 24 "granulocytes: 2.1;NK-cells: 2.5" "Group enriched" "Detected in some" 4 "EFO-21: 106.3;HUVEC TERT2: 238.4;TIME: 210.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "Intracellular and membrane" NA NA 87000000 "Cluster 41: Basophils - Cellular respiration" "Cluster 82: Adipose tissue - ECM organization" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "unprognostic (1.88e-1)" "unprognostic (1.26e-1)" "unprognostic (7.60e-3)" "unprognostic (1.01e-1)" "unprognostic (3.91e-2)" "unprognostic (1.53e-3)" "unprognostic (1.19e-2)" "unprognostic (7.83e-2)" "unprognostic (2.02e-1)" "unprognostic (9.34e-2)" "unprognostic (1.91e-2)" "unprognostic (2.25e-1)" "unprognostic (1.17e-3)" "unprognostic (2.16e-2)" "unprognostic (1.89e-1)" "unprognostic (1.29e-2)" "unprognostic (2.35e-2)" 47.0 10.1 16.6 8.1 14.8 0.9 37.8 14.6 16.9 14.0 10.1 11.2 5.2 20.4 5.3 6.5 16.0 13.3 34.2 13.1 14.2 19.8 6.7 35.3 10.1 16.4 16.5 7.5 4.2 3.2 8.0 48.6 16.8 10.8 3.1 0.4 7.4 6.5 14.0 7.9 11.0 14.1 13.9 19.9 8.8 3.0 21.1 2.1 24.2 20.7 2.9 15.1 11.8 14.8 0.0 0.0 3.6 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.0 0.0 0.1 106.3 0.0 0.0 0.0 0.0 0.0 1.8 0.1 0.0 41.9 0.0 0.4 0.6 0.0 0.0 0.0 0.0 0.2 0.0 1.7 238.4 0.0 0.0 0.0 0.0 0.0 0.0 20.4 1.3 0.0 0.1 8.1 16.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.9 0.0 0.1 210.0 1.2 0.4 0.0 0.2 0.0 0.2 0.4 0.0 0.0 3.9 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 0.0 0.0 16.6 14.8 14.6 16.9 13.1 14.2 16.4 16.5 16.8 13.9 21.1 14.8 130.8 0.0 4.2 0.0 0.4 2.2 0.6 0.0 1.2 0.3 1.0 0.9 4.9 1.5 1.8 0.0 0.0 0.3 0.7 0.9 0.0 0.0 2.0 0.1 0.4 108.8 0.0 2.5 0.4 0.2 0.1 3.1 0.0 0.4 20.3 0.1 128.8 1.3 0.5 0.0 0.2 0.1 0.0 5.6 3.1 2.5 2.1 1.1 1.8 29.0 0.1 0.1 1.0 1.0 1.1 0.0 0.0 0.7 0.1 0.7 0.1 0.9 3.6 0.9 0.0 2.2 2.2 0.9 0.7 0.5 1.4 0.3 2.3 0.5 0.2 0.7 TK1 ENSG00000167900 "Thymidine kinase 1" P04183 17 78174091-78187233 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA synthesis" "Kinase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 77.9" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 92.8;Erythroid cells: 108.6;Extravillous trophoblasts: 210.4;Hofbauer cells: 65.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "T-reg: 34.0" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Region enhanced" "Detected in some" "white matter: 3.6" "Low region specificity" "Detected in many" CAB004683 Enhanced NA Yes "Cluster 4: T-regs - Cell cycle regulation" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" "CAB004683: AB_437067" "unprognostic (7.09e-2)" "unprognostic (1.17e-3)" "unprognostic (1.82e-1)" "unprognostic (2.14e-3)" "unprognostic (3.22e-1)" "unprognostic (1.94e-1)" "prognostic unfavorable (6.87e-4)" "prognostic unfavorable (3.03e-5)" "unprognostic (4.05e-2)" "unprognostic (3.18e-3)" "unprognostic (6.64e-3)" "unprognostic (2.76e-2)" "prognostic unfavorable (6.50e-11)" "unprognostic (5.55e-3)" "unprognostic (1.92e-1)" "unprognostic (1.42e-1)" "unprognostic (4.94e-2)" 3.7 2.7 2.5 20.4 3.4 77.9 5.9 3.6 3.4 5.9 1.3 24.4 18.0 3.0 0.2 27.2 4.9 3.4 2.8 2.7 2.4 11.0 9.2 9.1 34.8 3.4 3.3 1.3 5.6 0.6 0.6 14.8 3.3 3.4 15.7 0.1 6.3 1.5 5.5 14.2 18.3 10.1 2.6 12.4 17.9 3.1 3.8 25.1 2.0 1.6 30.6 5.5 9.0 4.4 443.9 357.7 68.2 92.5 7.6 28.0 47.3 207.6 113.2 323.1 442.3 324.2 178.7 144.1 72.9 131.7 133.9 204.2 63.4 187.1 158.0 51.2 230.4 252.5 119.9 213.3 2.2 107.1 162.9 13.8 7.1 166.1 22.5 22.3 137.9 49.4 156.7 311.9 130.8 352.0 56.0 68.6 36.7 259.1 240.9 152.6 276.4 324.1 90.6 138.5 33.6 94.2 162.0 481.2 59.7 59.4 303.9 156.1 57.8 302.3 305.7 219.9 292.1 132.5 71.4 181.9 149.0 71.9 142.1 0.0 1.1 0.0 1.8 2.1 0.7 5.8 7.9 4.0 3.4 1.7 0.4 2.2 1.8 10.8 1.7 1.1 34.0 5.5 2.5 3.4 3.6 3.4 2.7 2.4 3.4 3.3 3.3 2.6 3.8 4.4 1.6 0.0 2.7 0.0 17.1 28.4 13.3 17.8 2.2 0.0 10.6 9.4 0.9 2.8 8.3 12.9 0.0 92.8 3.6 35.0 7.9 7.7 3.0 9.2 3.3 10.6 5.4 108.6 0.3 11.2 210.4 15.7 19.4 7.0 0.0 15.9 7.5 10.5 65.2 0.0 0.2 32.7 8.2 15.5 19.1 6.8 0.6 10.9 3.6 0.0 5.7 0.0 3.1 0.0 1.0 9.6 7.5 0.7 53.6 4.9 3.1 17.5 5.8 0.0 0.0 1.7 20.1 3.8 16.8 24.7 11.2 51.0 8.7 1.7 60.8 24.0 TK2 SCA31 ENSG00000166548 "Thymidine kinase 2" O00142 16 66508003-66552544 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "DNA synthesis" "Kinase, Transferase" "Disease variant, FDA approved drug targets, Primary mitochondrial disease, Progressive external ophthalmoplegia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041162 Uncertain NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 68: Epididymis - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "HPA041162: AB_10961178" "unprognostic (1.12e-1)" "unprognostic (2.11e-1)" "unprognostic (1.12e-1)" "unprognostic (6.27e-3)" "unprognostic (3.94e-1)" "unprognostic (2.93e-1)" "unprognostic (1.10e-1)" "unprognostic (4.83e-2)" "unprognostic (3.35e-2)" "unprognostic (3.45e-1)" "unprognostic (3.59e-2)" "unprognostic (2.85e-1)" "prognostic favorable (2.18e-6)" "unprognostic (3.05e-2)" "unprognostic (1.74e-1)" "unprognostic (2.71e-1)" "unprognostic (7.05e-2)" 48.1 30.2 24.2 11.8 27.6 8.5 25.6 24.7 25.7 20.0 19.7 15.0 10.9 16.2 29.3 12.3 19.0 21.1 19.2 24.1 25.6 25.1 37.3 18.7 11.7 26.5 27.8 26.8 24.4 38.0 22.4 15.1 27.6 19.2 12.7 11.7 22.6 19.9 11.5 12.7 13.5 18.9 27.5 23.0 15.7 33.9 25.8 13.0 25.6 14.6 9.9 17.8 15.4 28.3 13.3 26.5 12.1 14.5 64.3 52.2 0.7 22.0 22.3 15.1 16.8 6.5 26.4 0.1 23.8 63.9 19.0 11.8 5.3 17.7 10.4 8.5 6.2 4.1 17.2 12.9 45.1 5.6 9.2 39.4 15.3 18.5 26.1 62.5 19.9 13.1 6.8 28.1 37.9 4.1 5.5 14.9 5.9 5.1 15.4 7.0 21.0 28.1 44.1 12.5 4.4 8.9 63.2 6.1 26.9 6.6 9.6 16.3 29.7 30.8 15.9 26.3 7.6 30.3 12.2 11.6 38.9 5.7 18.4 5.6 9.4 6.0 1.8 5.1 1.2 0.1 1.3 1.0 8.7 1.7 0.6 0.9 8.5 2.7 4.3 1.8 1.2 2.5 24.2 27.6 24.7 25.7 24.1 25.6 26.5 27.8 27.6 27.5 25.8 28.3 25.0 22.4 9.3 19.6 7.3 5.7 5.1 5.8 12.5 15.5 15.4 11.4 8.0 17.2 7.5 22.0 22.9 10.0 7.6 6.0 9.8 15.7 25.2 15.2 23.2 14.4 9.6 10.3 10.1 22.4 6.0 19.9 11.7 13.0 24.8 20.6 31.1 48.9 21.7 21.9 12.0 6.5 2.0 55.6 10.1 40.5 23.3 23.6 10.6 10.3 22.6 18.4 12.3 14.6 19.4 28.9 3.3 19.2 12.4 4.3 14.4 45.9 9.0 20.5 0.0 14.4 10.6 48.9 11.1 9.6 3.8 2.9 8.6 22.2 7.6 4.2 TKFC "DAK, DKFZP586B1621, NET45" ENSG00000149476 "Triokinase and FMN cyclase" Q3LXA3 11 61333220-61353295 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Lyase, Multifunctional enzyme, Transferase" Cataract "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 192.8;liver: 115.8" "Cell type enhanced" "Detected in many" "Hepatocytes: 115.9;Proximal enterocytes: 415.8;Proximal tubular cells: 91.2;Theca cells: 93.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "Hep G2: 133.2;RPMI-8226: 140.7;T-47d: 135.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039486, HPA048186" Enhanced Approved Nucleoplasm,Cytosol NA NA 6800000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 25: RPMI-8226 - Immune response" "Cluster 45: Enterocytes - Digestion" Cytosol Nucleoplasm "HPA039486: AB_10795402, HPA048186: AB_2680305" "unprognostic (4.00e-1)" "unprognostic (3.13e-1)" "unprognostic (7.42e-2)" "prognostic favorable (1.32e-5)" "unprognostic (1.07e-1)" "unprognostic (1.19e-1)" "unprognostic (3.02e-2)" "unprognostic (2.81e-3)" "unprognostic (1.49e-1)" "unprognostic (2.47e-1)" "unprognostic (1.51e-1)" "unprognostic (2.15e-1)" "prognostic favorable (8.38e-5)" "unprognostic (2.07e-2)" "unprognostic (8.96e-2)" "unprognostic (3.30e-1)" "unprognostic (4.02e-1)" 9.5 82.8 5.9 9.4 6.0 16.6 12.1 5.8 6.6 9.5 5.7 12.5 192.8 11.0 7.6 16.3 15.4 9.2 7.6 6.4 5.1 45.5 115.8 9.0 13.6 6.8 6.3 10.3 24.0 6.7 14.0 6.1 6.2 12.2 5.7 5.6 16.2 8.9 10.9 17.8 138.0 5.2 6.5 13.0 16.6 28.2 6.0 7.5 14.7 5.6 8.0 10.9 11.0 7.2 19.9 51.3 8.5 30.0 10.7 11.4 24.2 11.7 12.4 10.4 6.9 23.1 47.1 25.0 39.3 8.5 11.0 27.7 16.3 21.8 3.5 42.5 21.7 15.7 26.2 133.2 17.9 13.4 25.0 18.2 14.5 9.9 35.4 9.4 10.7 17.1 27.2 46.7 7.9 91.8 11.9 11.9 23.8 19.2 33.8 20.0 13.8 140.7 17.1 35.0 33.0 29.6 21.0 36.4 19.3 6.0 135.4 9.2 13.0 21.0 21.6 16.6 7.0 85.8 76.5 22.9 21.3 12.3 19.7 2.6 13.4 6.5 7.1 7.8 9.6 10.3 8.3 7.1 21.2 9.7 5.8 6.2 1.2 6.5 6.5 10.1 12.9 9.7 5.9 6.0 5.8 6.6 6.4 5.1 6.8 6.3 6.2 6.5 6.0 7.2 8.0 0.0 14.5 0.0 9.5 0.0 13.8 0.0 11.4 12.8 19.1 16.0 3.8 11.5 6.8 14.7 14.6 31.2 8.3 4.8 29.4 19.6 16.2 16.4 6.6 8.0 13.3 7.8 0.0 14.6 6.2 11.2 20.4 12.1 7.6 10.8 7.5 115.9 17.1 8.4 0.0 31.6 0.0 17.2 0.0 12.0 15.2 8.2 0.0 0.0 21.2 10.0 9.2 0.0 0.0 11.2 32.9 22.6 11.0 11.1 415.8 91.2 10.9 17.8 6.6 4.7 3.6 37.5 14.1 12.6 0.0 15.2 6.5 93.6 47.6 13.4 TKT ENSG00000163931 Transketolase P29401 3 53224712-53256052 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" Transferase "Disease variant, Dwarfism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 667.0" "Cell type enhanced" "Detected in all" "Kupffer cells: 696.7;monocytes: 624.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 6 "classical monocyte: 447.9;eosinophil: 274.4;intermediate monocyte: 199.0;myeloid DC: 203.8;neutrophil: 375.3;non-classical monocyte: 242.6" "Group enriched" "Detected in all" 9 "dendritic cells: 203.8;granulocytes: 375.3;monocytes: 447.9" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA029480, HPA029481" Enhanced Enhanced Nucleoplasm NA NA 150000000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 20: HeLa - Mitochondria" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Nucleoplasm "HPA029480: AB_10599307, HPA029481: AB_10601895" "unprognostic (5.05e-2)" "unprognostic (3.34e-2)" "unprognostic (1.02e-2)" "unprognostic (1.77e-2)" "unprognostic (2.06e-1)" "unprognostic (1.02e-2)" "prognostic unfavorable (7.21e-6)" "unprognostic (6.78e-2)" "unprognostic (1.70e-1)" "unprognostic (4.73e-2)" "unprognostic (3.06e-3)" "unprognostic (1.36e-2)" "unprognostic (2.08e-1)" "unprognostic (2.99e-1)" "unprognostic (1.07e-1)" "unprognostic (3.29e-1)" "unprognostic (9.90e-3)" 152.2 93.2 78.0 66.2 80.0 667.0 71.9 93.2 82.3 59.7 60.5 73.2 84.2 44.7 19.2 168.5 53.7 97.2 27.4 72.3 96.9 68.2 58.1 93.4 69.2 89.2 89.9 87.7 154.0 41.4 45.6 61.2 93.8 48.8 48.8 21.7 54.9 50.9 12.8 47.0 58.1 51.6 77.4 99.8 66.1 20.2 87.9 82.9 116.1 15.2 67.4 130.9 85.5 97.2 313.0 1542.9 216.0 241.5 470.8 570.8 439.5 206.2 353.8 348.8 330.8 430.1 779.3 388.5 96.8 302.9 673.3 438.3 377.9 775.8 102.4 131.0 210.3 259.6 1022.2 655.2 573.9 321.4 168.1 416.0 437.5 418.5 213.7 949.2 444.9 323.8 188.3 164.7 144.5 381.6 338.6 358.1 737.1 603.0 367.9 201.1 98.5 726.2 550.3 520.2 139.6 103.7 383.4 605.3 365.1 656.7 188.8 437.4 335.9 107.2 164.2 320.0 401.9 94.5 190.3 235.7 234.4 321.0 203.8 51.5 447.9 274.4 17.8 199.0 22.8 39.7 25.8 20.6 203.8 21.1 26.6 20.7 375.3 30.8 242.6 34.4 36.7 312.4 78.0 80.0 93.2 82.3 72.3 96.9 89.2 89.9 93.8 77.4 87.9 97.2 79.5 134.6 125.6 46.7 92.1 79.4 384.6 325.3 287.4 41.0 99.3 80.5 14.9 75.8 149.5 62.5 29.2 349.0 69.7 139.1 80.3 197.7 6.5 87.4 79.6 81.8 52.6 150.3 16.9 269.8 249.8 80.2 168.7 95.5 62.7 123.6 75.0 83.4 256.0 37.0 23.9 149.6 142.4 696.7 110.5 8.9 157.2 333.3 76.5 17.8 624.4 88.8 46.4 17.1 39.3 193.6 81.4 106.8 109.4 337.7 141.5 219.1 99.2 46.3 52.6 35.9 102.1 16.8 30.6 409.3 67.1 413.6 78.8 427.2 276.7 413.6 TKTL1 "TKR, TKT2" ENSG00000007350 "Transketolase like 1" P51854 X 154295795-154330350 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 29 "testis: 127.1" "Group enriched" "Detected in some" 7 "Spermatocytes: 166.9;Spermatogonia: 491.5" "Cancer enriched" "Detected in many" 8 "testis cancer: 44.2" "Group enriched" "Detected in some" 5 "cerebral cortex: 4.3;medulla oblongata: 1.7" "Group enriched" "Detected in many" 5 "eosinophil: 60.9;gdT-cell: 24.4" "Group enriched" "Detected in many" 5 "granulocytes: 60.9;T-cells: 24.4" "Cell line enriched" "Detected in some" 163 "THP-1: 495.2" "Not detected" "Not detected" "Region enhanced" "Detected in single" "white matter: 1.2" "HPA000505, HPA029155, CAB032191" Enhanced Enhanced Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 74: Testis - Spermatogenesis" "Cluster 43: THP-1 - Innate immune response" "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" Cytosol "CAB032191: , HPA000505: AB_1858022, HPA029155: AB_10603134" "unprognostic (2.69e-1)" "unprognostic (1.92e-1)" "unprognostic (1.98e-1)" "unprognostic (5.80e-3)" "unprognostic (2.43e-1)" "unprognostic (1.83e-1)" "unprognostic (1.36e-2)" "unprognostic (1.00e-1)" "unprognostic (2.10e-2)" "unprognostic (1.61e-1)" "unprognostic (1.98e-1)" "unprognostic (2.01e-1)" "unprognostic (1.63e-1)" "unprognostic (1.34e-2)" "unprognostic (3.90e-2)" "unprognostic (5.04e-2)" "unprognostic (2.38e-1)" 0.3 0.1 0.3 0.4 0.4 0.9 0.2 0.2 4.3 0.3 0.5 0.0 0.0 0.0 0.2 0.0 0.0 0.1 3.8 0.3 0.3 0.3 0.2 1.0 0.4 1.7 0.2 0.1 0.0 0.0 0.9 0.3 0.6 0.1 0.0 2.2 0.0 0.0 0.3 0.2 0.1 0.1 0.5 0.7 0.0 127.1 0.5 0.4 0.1 0.5 0.1 0.1 0.1 0.5 0.3 0.0 0.1 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 1.6 0.0 0.0 495.2 0.0 0.0 0.0 0.1 0.2 0.0 3.0 2.7 0.0 0.0 0.4 1.6 0.1 60.9 24.4 0.4 3.5 0.1 2.9 2.2 0.0 0.1 6.0 5.4 1.0 7.8 0.3 0.2 3.5 5.8 0.3 0.4 0.2 4.3 0.3 0.3 1.7 0.2 0.6 0.5 0.5 0.5 0.2 0.0 0.0 0.7 0.5 0.3 0.0 0.0 0.6 0.3 0.0 0.0 20.4 0.0 0.0 0.0 0.0 0.0 16.4 0.0 0.0 0.0 44.8 0.0 0.1 0.7 0.0 0.4 0.4 0.0 0.0 0.7 0.0 0.1 0.0 0.1 0.0 0.1 0.2 25.2 0.4 0.0 0.0 0.3 3.7 22.5 4.1 1.9 0.0 1.0 0.6 6.0 20.6 1.0 0.1 0.0 0.0 1.9 1.3 0.0 0.0 0.1 0.0 1.0 26.3 1.4 1.6 166.9 491.5 0.1 0.1 0.0 4.1 0.1 0.0 0.0 TKTL2 "DKFZP434L1717, FLJ32975" ENSG00000151005 "Transketolase like 2" Q9H0I9 4 163471095-163473754 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in single" 375 "testis: 57.8" "Group enriched" "Detected in some" 26 "Early spermatids: 76.3;Late spermatids: 40.8;Spermatocytes: 156.6" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 66: Spermatocytes - Spermatogenesis" "unprognostic (2.19e-1)" "unprognostic (1.55e-1)" "unprognostic (8.62e-2)" "unprognostic (2.05e-2)" "unprognostic (2.90e-1)" "unprognostic (2.21e-1)" "unprognostic (7.72e-2)" "unprognostic (1.15e-1)" "unprognostic (1.15e-2)" 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 57.8 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 76.3 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 40.8 3.4 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.3 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 156.6 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 TLK1 "KIAA0137, PKU-BETA" ENSG00000198586 "Tousled like kinase 1" Q9UKI8 2 170990823-171231314 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, DNA damage" "Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016043 Approved Supported Nucleoplasm NA NA "Cluster 49: Eosinophils - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "HPA016043: AB_1858027" "unprognostic (2.13e-2)" "unprognostic (3.87e-1)" "unprognostic (7.36e-2)" "unprognostic (6.00e-3)" "unprognostic (2.00e-1)" "unprognostic (6.78e-2)" "unprognostic (2.47e-2)" "unprognostic (7.60e-2)" "unprognostic (1.61e-1)" "unprognostic (5.26e-2)" "unprognostic (2.57e-1)" "unprognostic (1.11e-1)" "unprognostic (6.13e-2)" "unprognostic (2.08e-1)" "unprognostic (1.55e-1)" "unprognostic (2.63e-1)" "unprognostic (1.53e-1)" 7.7 10.2 5.9 10.7 8.3 11.1 12.3 4.1 10.5 12.7 5.1 13.0 9.4 10.6 5.4 9.4 9.5 9.6 7.0 10.1 4.6 13.0 14.8 8.4 15.0 3.5 7.3 14.0 10.4 18.0 6.2 15.2 3.4 11.8 12.3 15.8 9.2 14.6 16.3 8.5 11.8 11.7 4.4 13.2 13.5 17.7 10.6 13.8 17.6 5.5 15.7 11.7 8.3 7.6 16.6 15.6 22.0 17.3 15.4 15.3 24.7 22.5 31.9 21.8 18.2 21.8 25.9 34.2 18.7 33.4 23.6 13.7 28.5 24.6 23.8 42.1 14.9 39.1 18.5 28.0 16.5 50.3 19.0 16.7 24.6 43.4 28.4 23.0 24.3 21.2 42.3 27.4 13.2 20.3 43.8 15.5 20.6 15.5 8.9 31.9 26.9 34.7 17.7 30.9 25.0 19.7 24.7 16.7 16.1 14.9 13.8 17.0 33.2 19.3 24.0 12.7 17.8 24.5 43.0 59.7 23.9 20.1 19.9 11.1 3.1 5.7 5.2 2.6 7.3 8.3 8.3 5.7 3.0 8.3 9.3 6.2 4.2 8.1 5.3 4.4 8.5 5.2 5.9 8.3 4.1 10.5 10.1 4.6 3.5 7.3 3.4 4.4 10.6 7.6 34.2 51.3 27.8 135.8 76.7 41.3 33.2 27.1 30.7 34.8 45.9 28.4 32.1 37.1 29.2 51.5 60.5 82.7 42.6 55.8 88.0 29.2 58.1 29.5 33.9 34.5 23.9 33.7 196.2 32.7 52.7 30.3 37.8 38.4 27.3 39.5 27.5 40.0 27.4 45.4 161.0 36.7 36.7 29.0 30.4 32.0 43.2 54.7 37.4 74.0 29.1 26.6 49.4 84.9 92.0 35.6 36.5 44.8 66.3 51.0 33.4 58.0 30.7 77.5 0.0 41.6 29.6 31.1 54.9 24.5 39.1 174.9 66.4 59.2 33.9 43.0 TLK2 "MGC44450, PKU-ALPHA" ENSG00000146872 "Tousled like kinase 2" Q86UE8 17 62458658-62615481 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, DNA damage" "Chromatin regulator, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 173.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 23: Testis - Cell cycle regulation" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 25: Spermatids - Spermatogenesis" "unprognostic (2.50e-2)" "unprognostic (2.12e-1)" "unprognostic (7.06e-2)" "unprognostic (1.48e-2)" "unprognostic (9.53e-3)" "unprognostic (6.57e-2)" "prognostic unfavorable (9.40e-4)" "unprognostic (4.53e-2)" "unprognostic (5.28e-2)" "unprognostic (2.32e-1)" "unprognostic (2.82e-2)" "unprognostic (4.78e-2)" "unprognostic (5.32e-2)" "unprognostic (9.79e-2)" "unprognostic (4.32e-2)" "unprognostic (4.88e-1)" "unprognostic (7.30e-2)" 19.9 16.9 7.5 21.1 14.9 36.1 11.8 19.8 12.0 12.4 9.5 21.7 20.5 22.9 8.7 23.6 13.2 20.9 22.6 9.8 17.5 15.2 12.5 16.2 25.5 18.1 14.2 21.6 18.0 16.0 9.8 17.4 14.4 16.0 14.8 43.4 16.5 11.4 32.4 23.7 20.5 16.1 10.0 21.4 18.6 52.1 12.8 23.2 30.0 21.8 17.2 19.1 10.9 25.5 40.9 36.9 62.2 66.4 20.3 26.0 36.6 44.1 34.4 51.7 46.6 39.0 35.7 79.0 22.0 29.2 45.1 27.2 45.1 19.0 48.9 42.3 36.1 54.2 33.6 39.2 36.2 57.9 33.1 22.7 25.4 34.7 41.7 31.2 25.9 44.9 54.4 36.0 28.3 89.2 82.7 22.0 39.8 24.4 30.9 55.9 81.8 25.7 24.9 40.7 66.9 90.6 37.6 25.5 57.1 52.0 43.2 51.8 34.9 71.2 66.9 32.5 50.6 40.1 54.5 72.3 29.4 29.1 38.2 2.5 1.4 4.9 1.2 1.2 1.3 2.2 2.1 1.5 1.3 2.2 1.7 2.3 2.8 3.9 1.3 1.9 2.8 0.9 7.5 14.9 19.8 12.0 9.8 17.5 18.1 14.2 14.4 10.0 12.8 25.5 27.5 32.1 26.7 33.6 22.1 22.7 14.4 9.6 9.1 62.2 17.3 14.0 27.3 11.5 11.6 14.7 83.4 11.5 29.5 19.9 11.7 10.3 107.7 28.7 34.4 22.3 18.0 23.6 37.7 10.0 12.0 19.0 10.7 36.4 20.8 27.7 13.6 10.3 12.5 28.6 37.2 16.0 14.2 18.2 19.7 173.0 21.1 22.0 17.8 37.5 15.1 22.4 15.5 45.8 67.1 15.7 21.8 17.7 24.5 21.2 14.8 7.3 27.2 84.5 6.6 30.0 21.9 81.7 38.0 18.7 21.9 15.2 21.4 30.8 15.8 21.3 TMEM129 D4S2561E ENSG00000168936 "Transmembrane protein 129, E3 ubiquitin ligase" A0AVI4 4 1715952-1721358 "Enzymes, Predicted membrane proteins" "Ubl conjugation pathway, Unfolded protein response" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 6: T47d - Mammary gland" "Cluster 53: Intestinal epithelial cells - Unknown function" "unprognostic (6.07e-2)" "unprognostic (1.54e-1)" "unprognostic (2.12e-1)" "unprognostic (2.85e-1)" "unprognostic (4.04e-2)" "unprognostic (1.22e-3)" "unprognostic (7.35e-3)" "unprognostic (4.82e-2)" "unprognostic (2.27e-1)" "unprognostic (2.94e-2)" "unprognostic (2.51e-3)" "unprognostic (2.81e-1)" "prognostic favorable (9.64e-8)" "unprognostic (1.47e-1)" "unprognostic (6.49e-2)" "unprognostic (3.08e-1)" "unprognostic (2.36e-3)" 20.8 33.7 30.2 11.0 31.2 6.1 20.6 30.2 30.7 23.7 37.1 34.4 22.0 27.8 10.1 25.0 26.7 11.8 38.6 27.9 28.1 41.2 46.9 21.7 13.0 35.0 32.6 25.8 36.9 33.2 43.0 10.2 29.5 29.6 8.5 6.4 32.9 19.1 30.9 20.3 26.1 9.5 33.2 25.9 31.6 15.4 32.2 8.1 35.5 18.7 8.2 27.0 19.8 30.1 16.1 18.4 15.0 22.4 27.0 15.7 17.3 12.7 20.4 13.0 13.9 13.6 38.8 20.9 14.9 13.7 23.1 15.8 7.7 16.2 2.2 14.5 23.1 11.9 13.9 17.5 22.0 16.4 19.9 26.1 34.2 7.1 6.5 30.1 20.3 19.4 13.2 15.1 12.4 12.6 22.4 26.5 23.3 17.6 22.4 14.3 7.9 26.0 32.6 17.6 34.7 21.4 10.9 19.0 17.3 5.3 39.3 7.5 14.0 15.0 11.3 13.3 12.5 37.7 12.1 10.0 17.3 22.2 16.4 0.1 1.7 0.0 1.6 1.1 1.4 0.7 1.4 1.2 1.6 0.9 1.0 0.7 0.3 1.0 1.2 3.7 0.7 1.1 30.2 31.2 30.2 30.7 27.9 28.1 35.0 32.6 29.5 33.2 32.2 30.1 13.2 22.4 9.3 17.0 11.4 5.1 15.2 9.6 13.6 27.2 15.4 13.0 12.9 18.6 6.6 23.9 6.2 20.9 26.8 28.8 25.4 20.4 1.1 7.9 8.2 12.4 13.1 8.6 7.3 19.6 7.8 17.4 12.8 8.4 10.2 14.7 15.4 19.9 17.9 25.2 9.0 26.5 14.2 11.7 4.9 3.1 30.4 8.7 10.6 13.1 7.2 39.6 25.7 8.0 11.9 14.1 14.9 36.1 13.1 16.8 24.0 18.4 7.9 19.7 13.1 21.9 17.1 7.1 5.6 13.7 9.5 5.5 12.1 22.7 33.8 11.3 TMTC1 "ARG99, FLJ31400, FLJ41625, OLF" ENSG00000133687 "Transmembrane O-mannosyltransferase targeting cadherins 1" Q8IUR5 12 29500840-29784759 "Enzymes, Predicted membrane proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Adipocytes: 105.0;Astrocytes: 64.6;Excitatory neurons: 186.0;Inhibitory neurons: 200.5;Skeletal myocytes: 60.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HHSteC: 83.0;HSkMC: 56.9;hTERT-HME1: 103.8;LHCN-M2: 58.8;RH-30: 122.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016720 Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 39: Non-specific - Mitochondria" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nucleoplasm, Cytosol" "HPA016720: AB_1858155" "unprognostic (1.67e-1)" "unprognostic (6.35e-3)" "unprognostic (1.18e-1)" "prognostic unfavorable (1.90e-4)" "unprognostic (1.63e-3)" "unprognostic (4.53e-2)" "unprognostic (3.88e-2)" "unprognostic (8.36e-2)" "unprognostic (1.77e-1)" "unprognostic (8.90e-3)" "unprognostic (3.08e-3)" "unprognostic (1.21e-1)" "prognostic unfavorable (5.49e-4)" "unprognostic (5.89e-3)" "unprognostic (6.38e-2)" "unprognostic (2.90e-1)" "unprognostic (4.51e-3)" 36.7 14.1 14.5 5.2 21.0 0.2 16.8 6.7 13.5 11.9 13.3 11.9 3.1 9.0 3.0 6.8 14.3 7.1 16.5 20.0 25.0 14.7 2.4 8.7 2.7 11.4 24.0 9.3 2.6 28.0 10.7 2.8 15.8 6.9 5.9 2.6 4.5 8.8 18.5 4.0 6.4 13.2 7.9 42.4 8.3 2.4 25.1 6.9 4.7 31.2 2.1 12.1 8.2 6.3 0.0 0.0 15.3 0.0 47.7 31.6 0.1 14.7 33.1 4.3 3.4 0.0 0.2 0.1 7.4 10.0 17.6 0.0 0.5 0.2 0.2 0.3 4.6 0.0 41.5 0.7 83.0 2.1 0.0 56.9 5.6 40.3 103.8 12.2 2.2 0.0 0.0 2.2 58.8 0.0 0.0 0.0 11.1 0.2 20.8 0.0 122.4 2.1 0.0 0.3 1.2 1.2 1.7 0.0 4.1 5.4 0.0 0.8 6.2 3.7 2.4 2.3 12.5 19.6 0.0 0.0 27.2 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 14.5 21.0 6.7 13.5 20.0 25.0 11.4 24.0 15.8 7.9 25.1 6.3 105.0 3.2 0.6 64.6 0.9 3.3 1.0 6.1 11.4 12.1 1.3 10.4 32.3 0.0 2.4 3.7 0.0 0.1 0.0 0.0 0.0 0.1 29.6 7.7 16.2 57.9 0.0 0.0 186.0 0.0 0.0 17.5 2.0 7.0 0.0 4.3 54.7 5.4 0.5 0.0 200.5 0.2 0.0 17.7 4.2 7.5 8.1 4.9 10.6 30.9 0.5 0.5 0.0 9.5 5.7 0.0 0.0 18.4 0.3 4.0 0.1 0.7 6.0 1.3 46.0 60.3 24.9 2.4 1.7 1.3 2.0 1.9 1.0 21.9 0.0 0.4 TMTC2 DKFZp762A217 ENSG00000179104 "Transmembrane O-mannosyltransferase targeting cadherins 2" Q8N394 12 82686880-83134870 "Enzymes, Predicted membrane proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "brain: 60.8" "Cell type enriched" "Detected in many" 5 "Oligodendrocytes: 2152.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AF22: 32.0;WM-115: 80.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026954, HPA026955" Uncertain Approved "Plasma membrane,Actin filaments" No No "Cluster 37: B-cells - Transcription" "Cluster 70: Brain - Nervous system development" "Cluster 17: WM-115 - Nervous system development" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Plasma membrane" "Actin filaments" "HPA026954: AB_2256025, HPA026955: AB_10602282" "unprognostic (1.56e-1)" "unprognostic (5.62e-2)" "unprognostic (9.61e-2)" "unprognostic (7.38e-2)" "unprognostic (2.60e-2)" "unprognostic (3.66e-2)" "unprognostic (1.05e-2)" "unprognostic (1.58e-1)" "unprognostic (1.25e-1)" "unprognostic (7.16e-2)" "unprognostic (1.73e-3)" "unprognostic (5.06e-2)" "prognostic favorable (2.84e-5)" "unprognostic (1.10e-1)" "unprognostic (1.60e-1)" "unprognostic (2.06e-2)" "unprognostic (8.06e-2)" 3.7 0.8 11.4 4.7 39.8 2.1 4.6 21.4 25.1 4.8 0.0 11.7 2.8 5.4 4.4 9.8 10.0 7.8 2.0 11.2 19.1 6.6 1.2 6.4 1.8 28.3 29.9 1.9 4.5 2.8 3.5 3.4 26.7 6.1 5.7 5.5 6.9 11.2 1.2 5.2 4.7 6.8 11.7 1.3 10.2 3.0 26.8 1.5 6.4 1.7 2.2 7.5 7.3 60.8 1.7 6.4 32.0 0.2 4.3 3.9 2.9 2.1 0.7 1.7 0.3 0.3 3.4 0.0 0.5 11.9 1.2 2.8 9.7 4.9 0.5 7.5 5.8 0.0 5.2 0.2 0.4 2.2 1.0 1.1 4.3 0.2 1.6 3.4 2.7 3.5 0.0 4.2 0.4 3.4 1.6 8.8 1.1 6.0 5.3 0.0 1.3 0.6 2.9 14.1 8.3 15.1 2.9 4.6 21.0 5.4 4.9 0.5 1.7 5.3 1.8 7.2 2.7 7.8 5.7 1.2 1.2 3.8 80.2 0.0 0.9 0.0 0.0 0.3 0.0 0.3 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.2 11.4 39.8 21.4 25.1 11.2 19.1 28.3 29.9 26.7 11.7 26.8 60.8 10.7 9.6 8.9 333.3 2.0 14.4 15.5 12.0 18.2 38.1 8.9 5.5 1.8 11.5 18.4 14.7 8.4 13.6 3.1 3.6 0.0 5.4 12.9 13.5 7.5 10.3 2.4 0.8 117.1 8.2 1.7 9.8 12.8 13.1 0.0 0.2 2.5 1.4 1.9 8.4 377.0 9.8 2.0 6.6 9.6 5.0 5.9 6.2 32.0 86.2 9.3 13.9 1.0 38.7 2152.4 9.4 3.3 1.2 7.3 11.9 2.7 2.1 17.0 1.6 6.6 0.8 2.2 0.6 2.2 16.2 11.5 4.1 2.8 1.0 5.9 14.5 TMTC3 "FLJ90492, SMILE" ENSG00000139324 "Transmembrane O-mannosyltransferase targeting cadherins 3" Q6ZXV5 12 88142296-88199887 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted membrane proteins, Transporters" Transferase "Disease variant, Lissencephaly" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Ionocytes: 75.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA038550 Approved NA NA "Cluster 42: Non-specific - Transcription" "Cluster 31: Skin - Epidermis development" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 61: Squamous epithelial cells - Keratinization" "HPA038550: AB_10672715" "unprognostic (1.05e-1)" "unprognostic (6.16e-2)" "unprognostic (1.50e-2)" "unprognostic (1.18e-2)" "unprognostic (1.90e-1)" "unprognostic (5.28e-2)" "unprognostic (3.62e-3)" "unprognostic (1.71e-2)" "unprognostic (1.46e-1)" "unprognostic (4.44e-1)" "unprognostic (8.07e-3)" "unprognostic (2.56e-2)" "unprognostic (2.28e-1)" "unprognostic (5.37e-2)" "unprognostic (1.52e-1)" "unprognostic (1.10e-1)" "unprognostic (1.68e-1)" 5.9 4.4 3.6 3.8 3.8 1.7 6.7 5.8 4.7 5.6 2.1 4.5 5.4 6.4 5.2 9.1 3.9 5.7 3.8 3.9 4.6 8.1 9.0 5.2 2.9 3.4 3.9 5.3 3.2 6.2 2.8 10.2 4.1 7.4 4.7 7.9 3.8 6.3 1.7 12.5 4.4 9.2 3.2 3.9 3.8 4.1 3.6 4.0 6.3 4.3 4.5 6.8 4.7 4.1 13.2 14.0 12.6 11.9 28.8 25.4 22.5 28.1 26.6 15.8 16.9 20.3 9.2 4.1 5.0 25.8 9.6 28.9 13.5 22.4 26.5 2.4 10.2 4.0 9.5 9.3 15.0 4.3 2.5 21.7 12.0 30.5 12.0 16.2 24.9 3.4 8.9 1.4 17.8 7.9 3.0 5.5 9.7 5.0 7.3 2.6 27.4 4.1 13.7 21.3 10.7 10.6 22.8 16.1 7.3 13.3 25.9 4.3 26.4 21.8 12.0 19.4 13.7 4.5 6.3 4.7 6.8 5.0 16.5 7.4 1.3 2.3 1.8 1.1 2.2 2.3 2.0 1.4 0.9 1.8 2.4 2.0 1.3 1.2 1.6 0.9 1.7 0.7 3.6 3.8 5.8 4.7 3.9 4.6 3.4 3.9 4.1 3.2 3.6 4.1 15.9 12.8 8.2 19.6 6.9 34.2 24.4 29.1 24.5 12.5 11.4 8.1 11.1 5.7 20.0 7.3 27.1 29.6 3.5 6.7 3.9 14.5 26.8 23.7 22.2 16.9 3.6 9.5 51.6 10.8 18.2 23.8 8.6 21.9 9.5 12.4 15.7 19.2 8.2 13.5 46.8 5.9 75.3 5.9 6.0 18.2 20.2 3.7 8.8 20.6 2.8 8.3 2.1 28.1 42.4 12.4 4.9 19.5 4.6 18.0 7.3 13.9 34.9 23.4 19.7 17.1 22.3 12.0 8.7 32.6 40.5 17.8 5.2 14.1 7.1 14.4 TMTC4 "FLJ14624, FLJ22153" ENSG00000125247 "Transmembrane O-mannosyltransferase targeting cadherins 4" Q5T4D3 13 100603625-100675093 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Oligodendrocytes: 139.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016489, HPA057056" Approved Approved Vesicles NA NA "Cluster 28: Myeloid DCs - Unknown function" "Cluster 45: Intestine - Brush border" "Cluster 28: BEWO - Transcription regulation" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Vesicles "HPA016489: AB_1858157, HPA057056: " "unprognostic (1.49e-1)" "unprognostic (1.87e-1)" "unprognostic (8.34e-2)" "unprognostic (1.35e-1)" "unprognostic (2.43e-2)" "unprognostic (1.96e-1)" "unprognostic (1.50e-2)" "unprognostic (1.96e-1)" "unprognostic (1.88e-2)" "unprognostic (1.09e-1)" "unprognostic (3.11e-1)" "unprognostic (2.34e-1)" "unprognostic (1.41e-1)" "unprognostic (1.99e-1)" "unprognostic (6.04e-2)" "unprognostic (9.18e-2)" "unprognostic (2.65e-2)" 5.2 4.2 13.4 5.9 22.9 3.1 6.5 18.9 34.0 6.9 11.5 8.4 9.9 9.6 8.0 5.1 14.3 5.7 4.0 14.0 16.0 12.5 11.3 4.3 4.8 21.6 19.4 6.1 10.5 10.7 3.3 5.0 21.9 8.7 8.5 10.0 8.7 6.0 13.6 7.4 8.6 7.0 17.9 4.3 9.2 11.8 19.1 7.1 8.1 8.7 5.7 7.7 4.6 32.2 10.4 7.7 42.2 21.2 5.7 10.5 44.6 5.5 5.0 5.0 4.1 8.1 17.5 29.6 18.4 5.0 12.0 6.8 13.5 7.8 6.6 16.9 9.3 12.6 15.4 13.0 7.1 15.7 0.4 14.7 11.1 2.2 8.8 14.8 23.5 16.1 9.5 3.7 5.7 9.2 12.5 9.0 11.3 27.8 7.8 13.9 7.7 6.8 19.8 7.4 21.1 21.9 11.1 19.7 5.3 26.0 14.6 44.6 36.6 4.8 8.2 4.1 9.7 9.5 9.1 5.8 22.4 9.9 13.5 0.0 1.1 0.1 1.3 1.2 1.1 1.0 1.3 2.1 3.3 1.2 1.5 0.5 0.0 0.7 1.8 2.3 2.1 0.8 13.4 22.9 18.9 34.0 14.0 16.0 21.6 19.4 21.9 17.9 19.1 32.2 4.7 6.4 3.9 18.9 4.5 3.1 7.2 4.2 3.4 19.0 10.7 4.1 11.3 18.6 6.2 5.5 8.4 11.6 5.6 7.7 1.9 11.6 5.8 12.2 9.7 8.4 10.7 5.0 11.1 18.7 19.8 6.2 6.1 14.4 0.0 12.8 39.7 15.3 4.3 26.9 19.4 10.1 2.0 6.9 2.5 6.2 4.1 3.7 3.6 9.4 3.3 8.2 5.2 15.1 139.6 13.0 7.4 6.8 3.6 10.9 10.5 14.2 6.8 8.6 6.6 4.2 5.8 9.7 32.3 7.9 5.8 3.1 4.1 5.3 11.7 5.3 TNIK KIAA0551 ENSG00000154310 "TRAF2 and NCK interacting kinase" Q9UKE5 3 171058414-171460408 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Neurogenesis, Wnt signaling pathway" "Kinase, Serine/threonine-protein kinase, Transferase" "Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 33.7" "Cell type enhanced" "Detected in many" "Astrocytes: 1074.4;Excitatory neurons: 248.4;Inhibitory neurons: 360.8;Oligodendrocyte precursor cells: 374.5;Oligodendrocytes: 205.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HEL: 65.2;HMC-1: 71.3;WM-115: 52.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA012128, HPA012297" Approved Supported Nucleoplasm,Cytosol NA NA 160000 "Cluster 52: Eosinophils - Transcription" "Cluster 10: Brain - Neuronal signaling" "Cluster 3: HMC-1 - Innate immune response" "Cluster 64: Astrocytes - Nervous system maintenance" Nucleoplasm Cytosol "HPA012128: AB_1858226, HPA012297: AB_1858225" "unprognostic (2.29e-1)" "unprognostic (1.12e-2)" "unprognostic (1.32e-1)" "unprognostic (5.90e-2)" "unprognostic (5.25e-2)" "unprognostic (9.23e-2)" "unprognostic (4.91e-2)" "unprognostic (2.41e-3)" "unprognostic (1.91e-1)" "unprognostic (7.81e-2)" "unprognostic (5.91e-2)" "unprognostic (1.96e-2)" "unprognostic (3.34e-3)" "unprognostic (2.41e-1)" "unprognostic (1.64e-1)" "unprognostic (2.13e-2)" "unprognostic (3.97e-2)" 1.4 4.4 25.7 6.2 33.7 4.4 2.1 4.1 17.5 1.3 0.0 8.2 21.0 3.4 0.9 4.1 2.8 5.1 9.4 20.8 15.7 3.8 3.1 8.9 6.7 25.5 18.7 1.5 3.7 0.5 8.4 1.9 6.3 3.5 6.7 19.4 1.9 4.6 23.2 1.0 21.3 4.3 19.0 4.5 7.0 7.7 20.1 7.0 6.3 23.6 5.3 4.8 2.1 10.7 0.9 1.2 43.4 4.7 0.8 0.1 10.4 9.3 2.5 7.3 4.8 41.5 16.9 0.0 3.4 9.0 6.9 14.1 6.3 2.6 7.3 0.3 9.8 65.2 3.7 0.0 19.0 13.0 71.3 6.1 5.9 4.3 0.9 15.7 43.6 10.5 23.3 0.1 1.1 1.1 4.1 13.5 18.2 30.6 17.9 0.0 11.8 16.6 12.0 0.1 2.1 2.3 5.8 0.4 9.6 4.1 20.4 2.9 0.5 0.0 7.9 20.5 7.1 0.1 0.0 0.1 1.8 13.8 52.1 4.6 0.1 10.5 3.5 0.0 4.4 0.0 4.2 3.2 0.0 0.2 5.8 3.1 0.1 2.4 0.1 0.0 5.3 1.0 25.7 33.7 4.1 17.5 20.8 15.7 25.5 18.7 6.3 19.0 20.1 10.7 0.7 6.4 50.4 1074.4 4.9 2.5 1.6 1.3 9.1 19.2 8.4 6.5 28.6 21.5 7.1 9.2 14.6 6.3 32.5 19.6 5.9 12.1 48.6 1.1 2.5 1.6 13.2 13.5 248.4 7.7 1.3 9.1 21.4 0.3 83.5 0.4 2.5 8.1 2.9 0.0 360.8 10.3 0.0 6.5 1.9 38.0 2.5 10.4 1.8 57.1 1.6 65.0 51.5 374.5 205.5 7.1 21.6 6.4 11.7 0.7 56.2 17.3 1.8 28.7 0.0 12.4 6.2 3.1 1.0 10.3 1.6 2.5 47.4 9.9 16.6 3.2 TNK1 KOS1 ENSG00000174292 "Tyrosine kinase non receptor 1" Q13470 17 7380534-7389774 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 13.1;Distal enterocytes: 13.9;Gastric mucus-secreting cells: 16.8;Proximal enterocytes: 11.6" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in single" "cerebellum: 1.9" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in some" "A-431: 5.7;HaCaT: 9.1;HBEC3-KT: 6.0;hTCEpi: 6.6;T-47d: 7.4" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA012065, HPA056452" Uncertain Approved "Cell Junctions" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 18: Non-specific - Mitochondria" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 35: Glandular cells - Unknown function" "Cell Junctions" "HPA012065: AB_1858165, HPA056452: " "unprognostic (4.90e-2)" "unprognostic (1.93e-1)" "unprognostic (2.95e-1)" "prognostic favorable (4.28e-4)" "unprognostic (2.84e-1)" "unprognostic (1.60e-1)" "unprognostic (1.41e-2)" "unprognostic (3.65e-1)" "unprognostic (2.20e-1)" "unprognostic (2.52e-2)" "unprognostic (2.43e-1)" "unprognostic (3.10e-1)" "prognostic favorable (6.40e-4)" "unprognostic (1.77e-3)" "unprognostic (1.61e-1)" "unprognostic (1.38e-1)" "prognostic favorable (1.52e-4)" 3.6 0.9 0.3 1.2 0.5 0.2 5.6 1.9 0.4 3.8 0.4 7.3 3.7 2.4 0.8 7.1 3.1 1.0 1.6 0.2 0.3 5.2 5.1 2.6 1.5 0.0 0.0 3.3 7.8 3.0 3.0 0.2 0.0 7.0 2.3 1.3 8.1 1.4 0.5 8.8 7.7 0.5 0.0 3.1 7.6 1.9 0.2 0.5 4.8 0.1 1.7 4.2 5.6 0.3 5.7 0.9 0.1 0.4 0.0 0.0 3.7 0.2 0.0 0.3 0.4 2.9 2.6 0.0 2.2 0.3 0.1 9.1 0.0 6.0 0.1 0.6 1.3 0.0 3.5 1.6 0.3 0.0 0.2 0.1 6.6 0.0 1.0 0.1 0.0 2.4 0.7 0.0 0.0 4.4 0.6 0.0 0.7 4.9 0.7 0.2 0.1 0.6 4.1 2.6 0.1 0.4 3.1 4.5 0.8 0.2 7.4 0.1 1.5 0.2 0.7 0.2 0.0 0.4 0.9 0.1 0.1 0.4 0.4 0.0 0.0 0.0 0.3 0.0 0.6 0.5 0.6 0.4 0.0 0.4 1.1 1.3 0.1 0.0 0.0 0.0 0.2 0.2 0.3 0.5 1.9 0.4 0.2 0.3 0.0 0.0 0.0 0.0 0.2 0.3 2.6 6.4 3.4 0.0 2.9 2.5 2.6 5.1 13.1 1.8 9.1 7.4 1.1 2.8 3.5 1.8 0.0 0.2 0.3 13.9 0.0 5.2 1.5 2.8 1.0 1.5 3.0 0.4 0.5 6.9 0.6 1.0 16.8 4.6 0.0 0.1 1.1 2.9 0.1 0.0 0.4 7.0 2.0 0.0 0.5 1.5 1.2 0.4 0.0 0.0 0.4 0.2 2.1 0.0 0.1 8.5 8.0 0.4 0.4 3.9 11.6 1.6 1.9 2.9 0.0 0.8 1.8 1.5 0.6 11.0 2.4 0.7 2.4 0.1 7.2 2.2 TNK2 "ACK, ACK1, p21cdc42Hs" ENSG00000061938 "Tyrosine kinase non receptor 2" Q07912 3 195863364-195911945 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Endocytosis "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 102.9" "Cell type enhanced" "Detected in many" "Horizontal cells: 99.3;Oligodendrocyte precursor cells: 245.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041954, HPA069561" Approved Supported "Vesicles,Plasma membrane" NA NA "Cluster 6: Non-specific - Transcription" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 44: HDLM-2 - Immune response" "Cluster 68: Oligodendrocytes - Mixed function" "Plasma membrane" Vesicles "HPA041954: AB_10794164, HPA069561: " "unprognostic (1.97e-2)" "unprognostic (1.05e-1)" "unprognostic (1.15e-3)" "prognostic unfavorable (8.96e-4)" "unprognostic (1.34e-1)" "unprognostic (8.92e-2)" "unprognostic (1.45e-1)" "unprognostic (1.30e-1)" "unprognostic (8.89e-3)" "unprognostic (1.13e-1)" "unprognostic (8.92e-3)" "unprognostic (4.49e-2)" "prognostic unfavorable (1.30e-4)" "unprognostic (6.82e-2)" "unprognostic (9.76e-2)" "unprognostic (1.44e-1)" "prognostic favorable (1.00e-4)" 14.2 10.0 77.1 24.7 64.1 72.2 15.0 40.0 102.9 18.0 11.8 18.5 9.4 13.8 11.1 19.1 17.1 10.5 18.4 75.6 51.4 7.7 10.5 14.1 30.0 77.5 59.8 13.4 12.1 6.1 36.4 12.7 70.1 21.1 6.3 9.3 26.3 11.8 54.8 62.3 16.1 9.2 45.5 27.0 19.7 12.0 57.0 16.0 10.0 16.7 20.1 19.4 19.3 60.6 93.4 16.3 15.4 13.4 15.3 11.5 80.0 17.7 16.7 11.7 9.4 15.6 79.3 25.9 55.1 24.2 17.4 34.1 14.9 22.2 3.5 61.8 15.4 22.0 36.2 10.4 7.9 13.5 10.2 7.8 30.7 11.7 17.9 26.7 13.3 9.2 11.3 30.6 9.4 67.1 5.3 39.7 12.3 24.6 29.1 13.8 15.6 26.0 7.2 51.2 16.2 16.5 9.5 37.6 21.3 11.3 71.4 11.9 18.9 19.1 13.0 11.4 48.6 70.8 9.2 17.0 22.1 38.0 15.4 1.4 1.2 0.3 0.9 1.5 0.4 1.3 0.8 0.4 0.5 2.5 0.5 0.5 2.7 0.4 1.4 1.5 0.1 0.7 77.1 64.1 40.0 102.9 75.6 51.4 77.5 59.8 70.1 45.5 57.0 60.6 9.3 6.4 7.7 44.4 14.6 6.9 8.1 6.0 4.6 30.6 13.0 12.6 16.1 7.2 8.9 0.0 50.1 13.4 11.0 18.0 1.9 4.0 1.0 4.1 5.4 11.1 6.1 12.8 42.7 5.3 3.3 4.6 14.3 4.1 1.3 4.5 11.7 19.2 8.1 99.3 45.3 2.3 6.1 16.0 11.7 1.2 6.5 13.7 5.4 20.6 16.2 5.9 21.6 245.3 25.1 29.5 9.6 6.4 10.7 8.2 0.9 1.6 7.6 20.3 0.0 4.8 5.7 6.4 11.2 11.0 10.5 4.2 12.5 1.7 6.4 19.0 TNKS "ARTD5, PARP-5a, PARP5A, pART5, TIN1, TINF1, TNKS1" ENSG00000173273 Tankyrase O95271 8 9555912-9782346 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Transporters" "Cell cycle, Cell division, Mitosis, mRNA transport, Protein transport, Translocation, Transport, Wnt signaling pathway" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 149.9;Excitatory neurons: 203.2;Inhibitory neurons: 230.6;Oligodendrocyte precursor cells: 313.1;Oligodendrocytes: 285.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA025690 Approved Approved "Nucleoplasm,Nuclear membrane,Nuclear bodies" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 21: Non-specific - Transcription" "Cluster 12: NES - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Nucleoplasm "Nuclear membrane, Nuclear bodies" "HPA025690: AB_10602249" "unprognostic (2.07e-1)" "unprognostic (1.72e-2)" "unprognostic (5.45e-3)" "unprognostic (8.22e-2)" "unprognostic (2.42e-1)" "unprognostic (1.27e-2)" "unprognostic (4.75e-2)" "unprognostic (1.13e-1)" "unprognostic (9.06e-2)" "unprognostic (8.01e-2)" "unprognostic (6.21e-2)" "unprognostic (9.10e-2)" "unprognostic (4.14e-2)" "unprognostic (1.12e-1)" "unprognostic (5.43e-1)" "unprognostic (7.76e-2)" "unprognostic (5.36e-2)" 7.3 9.3 14.2 6.5 20.5 12.2 9.9 18.5 15.8 12.1 6.9 7.5 6.0 10.5 17.5 5.9 8.2 6.2 7.0 13.4 16.8 6.1 7.5 6.6 8.5 21.5 18.5 13.1 7.5 12.5 12.6 7.9 22.2 7.8 6.8 21.0 7.1 7.7 18.4 11.4 7.8 7.1 14.7 6.5 7.2 20.3 18.3 10.5 9.7 11.8 8.6 7.9 6.9 32.2 8.8 11.5 28.8 17.4 17.8 23.7 10.7 13.4 15.1 10.7 12.0 6.9 6.9 18.9 5.4 13.2 14.3 9.2 16.5 12.5 15.4 4.9 8.6 13.3 10.7 15.6 16.0 6.9 7.9 16.9 14.8 11.1 21.6 17.3 14.6 14.5 12.7 19.6 19.9 5.8 17.5 10.4 18.9 9.7 6.7 13.9 17.8 5.5 12.8 17.8 29.1 21.4 10.5 9.9 19.3 17.3 6.6 10.2 19.7 17.4 10.6 11.9 10.0 6.7 11.8 13.3 18.7 9.5 17.1 2.4 1.1 0.9 2.0 1.1 1.0 1.9 1.6 1.9 1.4 3.2 1.8 2.2 3.5 1.5 1.4 1.8 0.8 0.7 14.2 20.5 18.5 15.8 13.4 16.8 21.5 18.5 22.2 14.7 18.3 32.2 19.7 16.0 11.7 130.9 23.1 11.5 12.8 11.4 12.0 34.1 15.8 13.6 17.0 15.7 12.0 9.2 14.6 11.2 14.9 9.2 1.9 12.4 149.9 19.9 30.6 15.5 13.8 14.5 203.2 8.5 10.9 20.3 19.9 20.9 10.1 33.7 18.9 18.0 7.1 42.1 230.6 10.8 16.2 9.4 8.5 76.3 16.8 10.3 12.4 92.8 8.4 15.1 5.2 313.1 285.7 13.4 12.8 18.0 20.7 12.8 17.2 6.9 28.1 37.0 0.0 28.7 16.6 37.7 15.4 12.9 15.5 12.3 18.1 39.5 12.2 12.8 TNKS2 "ARTD6, PARP-5b, PARP-5c, PARP5B, PARP5C, pART6, TANK2, TNKL" ENSG00000107854 "Tankyrase 2" Q9H2K2 10 91798426-91865475 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Wnt signaling pathway" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036606 Approved Microtubules NA NA "Cluster 24: B-cells - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 30: Epithelial cell lines - Translation" "Cluster 59: Non-specific - Transcription" Microtubules "HPA036606: AB_10673470" "unprognostic (1.12e-1)" "unprognostic (2.66e-1)" "unprognostic (4.16e-1)" "unprognostic (1.61e-2)" "unprognostic (3.07e-2)" "unprognostic (1.51e-2)" "unprognostic (2.14e-1)" "unprognostic (1.41e-1)" "unprognostic (2.93e-1)" "unprognostic (2.59e-2)" "unprognostic (1.50e-1)" "unprognostic (2.26e-2)" "unprognostic (1.00e-1)" "unprognostic (2.35e-1)" "unprognostic (1.69e-1)" "unprognostic (7.97e-2)" "unprognostic (2.53e-1)" 18.4 19.3 14.7 21.2 16.1 38.5 22.2 18.0 17.0 21.1 25.0 14.8 14.9 22.5 19.8 22.8 17.8 20.8 11.1 14.3 14.9 17.4 21.2 19.7 28.1 14.6 15.1 30.3 22.0 21.8 14.4 31.2 15.8 19.6 17.1 31.2 18.5 16.6 55.6 27.3 15.3 20.7 16.0 30.0 19.8 11.8 17.4 37.7 29.6 40.5 29.4 24.1 17.1 19.7 29.1 24.3 48.9 41.7 33.8 30.6 54.5 30.6 55.5 36.5 44.5 21.7 23.2 27.2 14.3 40.0 24.6 30.6 31.0 23.6 51.3 27.7 29.9 22.6 22.9 24.3 32.9 44.0 32.3 31.4 30.6 37.0 65.3 54.8 34.8 24.1 16.9 29.4 38.5 15.6 38.1 29.9 24.6 13.2 16.1 35.2 30.5 20.9 25.0 30.9 12.8 22.9 30.8 13.4 38.7 39.2 32.5 30.3 37.8 19.6 16.5 26.1 29.5 36.7 32.1 34.8 25.9 32.4 17.9 0.2 0.7 1.2 0.9 0.6 0.8 1.0 0.9 0.8 1.0 1.0 0.7 0.6 0.7 1.0 0.6 1.5 0.5 0.4 14.7 16.1 18.0 17.0 14.3 14.9 14.6 15.1 15.8 16.0 17.4 19.7 39.1 41.7 22.3 63.3 51.6 74.6 32.5 23.8 56.9 41.7 38.8 24.0 23.2 8.6 31.0 44.1 47.9 45.2 48.7 19.2 7.9 16.0 4.7 41.1 29.3 37.1 33.0 27.5 77.5 24.5 55.1 30.9 50.4 52.1 2.5 34.8 35.7 35.9 26.1 42.1 78.5 19.3 26.4 55.3 49.4 8.1 31.1 48.4 33.8 67.5 46.5 24.9 37.0 66.9 68.0 29.0 12.3 35.3 45.7 44.7 16.1 16.6 47.4 34.8 46.0 40.5 28.0 19.1 21.7 75.9 109.1 101.0 49.1 30.5 14.9 61.7 TNNI3K CARK ENSG00000116783 "TNNI3 interacting kinase" Q59H18 1 74235387-74544428 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Cardiomyopathy, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 8 "heart muscle: 58.7" "Cell type enhanced" "Detected in some" "Cardiomyocytes: 27.0;Early spermatids: 32.0;Late spermatids: 6.6;Proximal tubular cells: 8.0" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "CAPAN-2: 1.0" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 44: Heart - Cardiac muscle contraction" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 54: Cardiomyocytes - Muscle contraction" "unprognostic (1.04e-2)" "unprognostic (1.34e-2)" "unprognostic (3.83e-1)" "unprognostic (2.20e-1)" "unprognostic (3.46e-1)" "unprognostic (3.40e-2)" "unprognostic (3.05e-1)" "unprognostic (2.48e-3)" "unprognostic (2.00e-1)" "unprognostic (9.66e-2)" "unprognostic (5.04e-2)" "unprognostic (1.80e-1)" "unprognostic (3.59e-3)" "unprognostic (4.88e-3)" "unprognostic (1.20e-1)" "unprognostic (8.80e-2)" "unprognostic (8.77e-2)" 1.8 1.4 3.6 0.3 3.6 0.1 1.4 4.9 7.2 1.0 2.0 2.0 0.4 1.3 2.5 0.6 1.5 0.4 58.7 3.7 3.9 3.4 0.4 0.9 0.4 3.3 3.2 1.5 0.4 0.7 2.3 0.0 3.6 1.1 0.5 5.2 0.8 0.4 1.5 1.6 0.8 0.9 3.5 1.4 1.1 4.0 3.5 0.4 1.0 0.6 0.5 1.4 0.9 4.8 0.0 0.1 0.2 0.0 0.1 0.4 0.0 0.0 0.3 0.0 0.2 0.0 1.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.1 0.7 0.4 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.3 0.8 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 3.6 3.6 4.9 7.2 3.7 3.9 3.3 3.2 3.6 3.5 3.5 4.8 0.1 0.0 0.0 0.0 0.0 0.9 0.1 0.2 0.0 1.2 0.2 0.3 27.0 0.0 0.1 1.8 0.0 0.0 0.0 0.1 1.9 0.1 32.0 0.1 0.1 0.2 0.0 0.0 0.0 0.0 0.1 0.8 0.0 0.1 0.0 0.1 0.0 0.0 0.1 1.7 0.0 0.0 0.0 0.0 0.0 6.6 0.9 0.2 0.0 0.0 0.1 0.9 0.0 0.0 0.0 0.2 0.0 0.7 0.0 0.1 0.0 8.0 0.1 0.5 0.0 0.6 0.8 0.5 1.4 0.0 0.3 0.1 0.1 0.0 0.0 0.2 TOPORS "LUN, RP31, TP53BPL" ENSG00000197579 "TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase" Q9NS56 9 32540544-32552586 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, Ubl conjugation pathway" Transferase "Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 169.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 67.6" "Lineage enriched" "Detected in all" 4 "granulocytes: 67.6" "Cell line enhanced" "Detected in all" "HEL: 90.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA060640, HPA065661" Supported Supported Nucleoplasm NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 34: Non-specific - Transcription" "Cluster 36: HEL - Hemostasis" "Cluster 29: Early spermatids - Spermatogenesis" Nucleoplasm "HPA060640: AB_2684334, HPA065661: AB_2685527" "unprognostic (1.75e-1)" "unprognostic (1.73e-1)" "unprognostic (1.20e-2)" "unprognostic (1.14e-2)" "unprognostic (1.29e-1)" "unprognostic (1.01e-1)" "unprognostic (1.45e-1)" "unprognostic (1.37e-2)" "unprognostic (9.94e-2)" "prognostic favorable (7.07e-4)" "unprognostic (2.70e-1)" "unprognostic (3.61e-1)" "prognostic favorable (6.64e-6)" "unprognostic (1.22e-1)" "unprognostic (5.95e-2)" "unprognostic (3.13e-1)" "unprognostic (2.92e-1)" 9.8 9.8 5.4 8.4 6.3 25.2 12.4 10.5 8.5 10.3 7.3 9.2 8.3 11.4 10.0 9.9 7.6 8.7 6.8 5.4 6.6 13.2 16.2 9.3 9.3 6.1 6.1 15.3 8.6 14.0 6.9 10.0 6.2 11.2 9.3 11.5 7.6 9.3 7.2 9.6 8.8 11.2 5.9 10.5 8.9 14.8 6.6 14.5 14.1 10.4 10.1 10.3 7.2 8.3 16.6 15.1 20.4 17.9 24.4 21.8 12.9 20.7 19.5 16.9 19.5 9.5 8.3 26.8 11.7 20.8 14.8 10.9 24.2 23.5 23.6 22.5 13.3 90.8 25.2 11.9 15.1 26.1 24.0 17.9 25.8 24.4 17.1 20.9 20.8 20.1 16.1 13.6 27.9 8.9 23.5 47.6 27.2 12.3 15.2 23.9 18.1 12.2 22.5 17.2 10.1 16.1 20.7 11.2 13.8 22.9 11.3 14.7 22.0 18.4 18.6 9.6 15.5 9.5 16.2 28.5 17.0 14.8 8.4 38.8 10.0 21.3 9.6 9.8 10.3 9.4 10.4 11.4 10.2 10.8 13.9 13.8 67.6 15.0 13.6 8.2 13.5 7.3 5.4 6.3 10.5 8.5 5.4 6.6 6.1 6.1 6.2 5.9 6.6 8.3 69.2 54.5 32.0 10.7 49.1 47.2 45.3 33.7 61.5 46.8 32.7 28.6 18.4 25.8 37.0 25.8 37.5 31.9 63.4 26.3 19.6 25.1 169.9 36.2 38.1 48.8 45.9 66.5 14.5 18.4 16.9 42.0 25.0 45.5 41.8 43.6 26.4 24.3 17.7 55.5 15.5 22.9 44.7 19.1 35.3 21.8 33.2 31.8 19.6 7.5 30.4 43.5 36.0 13.0 22.4 21.1 24.3 32.7 39.5 39.0 24.3 22.7 22.3 42.0 19.7 54.0 48.2 54.4 53.7 39.0 47.6 50.8 55.4 43.1 24.0 49.8 TP53RK "BUD32, C20orf64, dJ101A2.2, Nori-2p, prpk, TPRKB" ENSG00000172315 "TP53 regulating kinase" Q96S44 20 46684365-46689444 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "tRNA processing" "Hydrolase, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Epilepsy, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 214.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HMC-1: 212.4;SK-MEL-30: 90.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004688, HPA015837" Approved NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 3: HMC-1 - Innate immune response" "Cluster 66: Spermatocytes - Spermatogenesis" "CAB004688: AB_426116, HPA015837: AB_1855776" "unprognostic (9.45e-2)" "unprognostic (3.73e-1)" "unprognostic (9.76e-2)" "prognostic unfavorable (6.70e-5)" "unprognostic (4.41e-2)" "unprognostic (2.63e-1)" "prognostic unfavorable (6.27e-5)" "unprognostic (9.16e-3)" "unprognostic (6.11e-2)" "unprognostic (2.10e-1)" "unprognostic (2.36e-1)" "unprognostic (5.72e-2)" "unprognostic (1.25e-2)" "unprognostic (3.37e-2)" "unprognostic (1.75e-1)" "unprognostic (1.59e-1)" "unprognostic (1.74e-2)" 6.5 7.7 6.0 7.3 5.3 6.3 8.9 4.7 6.1 6.9 2.6 6.5 4.8 7.0 4.6 8.8 6.3 5.7 5.1 5.0 6.1 6.8 7.0 5.7 11.2 5.1 5.3 6.2 5.4 7.4 6.2 6.0 5.0 7.9 6.0 6.4 7.1 6.1 6.7 9.6 5.9 6.8 4.8 7.0 7.0 12.1 6.9 13.2 8.0 5.3 11.9 10.6 6.8 6.5 12.7 8.7 17.9 15.9 18.5 15.1 16.6 17.7 16.3 22.7 16.4 24.7 8.0 32.2 26.1 14.6 20.3 19.6 23.1 20.3 19.6 7.9 12.0 31.0 8.4 22.4 24.3 20.2 212.4 20.3 24.2 15.8 15.4 10.6 15.3 12.7 21.5 13.1 19.6 19.1 31.0 35.5 14.6 18.1 29.8 17.9 16.2 19.1 15.2 14.1 21.6 11.5 21.3 42.1 90.7 9.3 15.4 21.8 15.7 26.3 15.5 17.5 19.8 14.5 19.6 24.7 15.2 15.2 12.6 36.6 16.1 28.4 16.9 15.8 19.5 19.9 18.2 19.4 16.7 19.3 19.9 17.1 2.7 22.5 14.6 25.4 25.5 17.4 6.0 5.3 4.7 6.1 5.0 6.1 5.1 5.3 5.0 4.8 6.9 6.5 12.6 9.6 13.1 5.2 14.3 50.7 54.8 45.9 39.9 9.4 22.8 21.2 7.0 18.6 27.7 9.2 12.5 42.6 23.9 10.4 27.4 28.9 214.7 13.3 25.6 17.5 13.1 16.2 5.0 23.8 73.6 29.1 23.4 14.2 22.9 14.6 11.0 12.2 25.8 15.2 4.7 16.5 32.6 14.4 28.5 49.9 22.1 13.1 37.4 4.7 17.9 8.1 21.6 6.0 6.0 34.7 4.9 16.1 8.4 62.6 15.5 31.1 18.0 10.4 6.6 8.8 26.1 87.6 15.6 35.2 61.8 88.7 19.4 26.8 13.1 59.9 TPK1 "HTPK1, PP20" ENSG00000196511 "Thiamin pyrophosphokinase 1" Q9H3S4 7 144451941-144836395 "Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Disease variant, FDA approved drug targets" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "intestine: 14.3" "Cell type enhanced" "Detected in many" "Early spermatids: 83.0;Excitatory neurons: 82.6;Inhibitory neurons: 76.3;Late spermatids: 95.8;Microglial cells: 110.5" "Cancer enhanced" "Detected in many" "renal cancer: 3.4" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "AN3-CA: 70.6;CACO-2: 17.2;EFO-21: 21.2;TIME: 16.3" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA021545, HPA021849" Approved Approved Vesicles NA NA 210000 "Cluster 28: Myeloid DCs - Unknown function" "Cluster 14: B-cells - Humoral immune response" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Vesicles "HPA021545: AB_1858209, HPA021849: AB_1858210" "unprognostic (4.05e-2)" "unprognostic (3.28e-2)" "unprognostic (2.38e-2)" "unprognostic (3.32e-2)" "unprognostic (2.42e-1)" "unprognostic (1.63e-1)" "unprognostic (7.62e-2)" "unprognostic (6.08e-2)" "unprognostic (2.37e-1)" "unprognostic (1.68e-1)" "unprognostic (3.76e-2)" "unprognostic (6.06e-2)" "unprognostic (1.45e-3)" "unprognostic (3.15e-1)" "unprognostic (2.87e-1)" "unprognostic (1.59e-1)" "unprognostic (9.22e-3)" 4.3 3.4 2.9 5.9 3.2 2.7 4.2 2.1 4.1 2.7 3.3 6.4 14.3 2.2 1.5 1.9 2.0 3.6 3.4 2.8 5.2 3.9 4.5 5.2 5.8 3.1 3.0 2.3 2.0 1.8 1.5 5.2 3.0 1.8 6.1 2.4 3.6 2.6 1.6 1.4 7.5 3.6 2.9 8.1 2.2 3.4 4.3 2.8 3.1 2.9 5.0 4.1 1.6 3.9 0.7 0.7 0.7 70.6 0.5 0.7 5.8 0.3 0.3 0.2 0.2 17.2 2.8 1.3 21.2 1.2 1.4 0.0 1.4 0.8 0.6 4.3 1.0 0.3 0.2 0.3 1.8 5.5 1.7 1.4 1.4 0.8 1.0 2.0 13.6 2.8 1.5 3.2 0.3 2.1 1.6 8.2 1.8 2.1 5.9 0.7 1.6 2.5 10.9 6.3 0.7 0.2 1.1 0.2 1.3 1.3 1.0 10.4 16.3 0.7 1.8 1.3 0.9 1.6 4.2 1.7 2.5 13.8 0.7 0.4 10.2 0.3 5.0 7.4 5.2 6.7 5.5 4.6 13.2 7.2 6.5 5.4 4.7 5.8 10.8 3.1 7.7 5.6 2.9 3.2 2.1 4.1 2.8 5.2 3.1 3.0 3.0 2.9 4.3 3.9 8.5 9.6 2.8 43.1 23.8 2.3 2.6 3.0 0.6 3.9 4.4 2.9 5.9 8.6 1.3 3.7 8.4 41.2 8.3 20.1 19.6 4.3 83.0 5.3 2.3 8.9 1.2 2.1 82.6 6.7 14.3 6.3 7.1 8.6 7.6 6.5 6.1 5.2 17.0 1.7 76.3 5.0 0.0 18.9 19.2 95.8 5.0 17.9 8.8 110.5 15.7 3.4 17.5 55.8 38.4 9.8 15.9 1.2 9.9 1.8 20.4 8.6 3.2 5.4 0.0 3.6 2.9 14.9 10.5 2.1 1.7 32.0 12.1 4.0 8.1 4.1 TPMT ENSG00000137364 "Thiopurine S-methyltransferase" P51580 6 18128311-18155077 "Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Predicted intracellular proteins" "Methyltransferase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "kidney: 76.4;liver: 68.8;thyroid gland: 76.9" "Cell type enhanced" "Detected in many" "Distal enterocytes: 144.6;Proximal tubular cells: 307.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019851, HPA062364" Enhanced NA NA 39000 "Cluster 7: Monocytes - Unknown function" "Cluster 7: Kidney - Transmembrane transport" "Cluster 17: WM-115 - Nervous system development" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA019851: AB_1858213, HPA062364: " "unprognostic (6.24e-2)" "unprognostic (3.16e-2)" "unprognostic (5.46e-3)" "prognostic unfavorable (8.45e-5)" "unprognostic (4.98e-2)" "unprognostic (2.25e-1)" "unprognostic (8.16e-2)" "unprognostic (4.36e-3)" "unprognostic (9.62e-2)" "prognostic favorable (1.41e-4)" "unprognostic (4.49e-2)" "unprognostic (3.40e-2)" "prognostic favorable (1.10e-4)" "unprognostic (7.56e-2)" "unprognostic (1.31e-1)" "unprognostic (1.07e-1)" "unprognostic (8.39e-3)" 5.8 16.4 9.2 12.9 12.2 10.0 10.0 10.5 12.2 7.7 9.6 34.5 34.5 6.9 17.5 10.3 7.0 10.4 12.2 10.4 9.7 76.4 68.8 9.3 10.0 9.8 9.7 4.5 11.6 18.0 7.5 5.6 9.9 10.8 35.1 13.1 12.1 6.6 13.2 10.3 28.9 10.5 9.3 11.0 12.2 6.7 9.9 9.2 76.9 11.7 10.1 15.9 7.4 9.8 24.5 7.3 7.9 19.9 12.9 24.9 19.5 27.7 30.8 23.3 36.2 17.1 5.9 3.1 20.3 37.0 18.0 12.0 11.3 20.0 38.6 16.2 16.2 20.0 12.0 25.2 14.1 9.3 17.4 14.5 21.2 26.0 16.5 15.1 32.9 13.5 40.6 5.6 17.2 11.1 9.6 12.7 13.2 33.9 20.7 11.9 19.6 13.8 27.2 24.8 13.0 10.0 18.3 31.9 36.9 19.9 22.9 9.0 14.0 53.1 10.3 28.0 40.0 8.1 38.9 8.0 19.0 12.3 54.5 8.7 22.1 7.2 11.6 46.7 14.9 2.7 9.2 11.1 32.3 2.6 8.1 11.2 2.2 10.4 40.7 6.5 16.2 17.2 9.2 12.2 10.5 12.2 10.4 9.7 9.8 9.7 9.9 9.3 9.9 9.8 13.9 16.0 15.5 4.6 12.6 42.7 41.3 23.0 13.6 15.3 20.9 15.0 22.9 25.8 15.8 35.0 22.9 20.7 20.5 144.6 115.4 52.7 1.2 38.4 15.3 14.3 24.0 18.1 18.7 37.4 25.3 11.3 14.8 39.4 22.9 4.3 17.5 86.5 44.9 6.7 13.2 34.8 22.4 48.5 60.9 2.8 4.1 41.1 24.9 9.4 32.6 33.5 29.9 11.1 10.2 76.8 106.6 10.1 9.7 38.8 80.8 307.6 12.2 19.5 0.0 9.3 13.9 0.7 7.7 19.5 34.5 17.5 21.1 9.5 50.7 78.9 TPST1 TANGO13A ENSG00000169902 "Tyrosylprotein sulfotransferase 1" O60507 7 66205317-66420543 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Endometrial stromal cells: 76.5;Excitatory neurons: 101.9;Inhibitory neurons: 107.1;Spermatocytes: 97.1" "Cancer enhanced" "Detected in all" "glioma: 36.5" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "basophil: 52.2;neutrophil: 35.2" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA047415, HPA061837" Approved Supported "Golgi apparatus" "Intracellular and membrane" NA NA "Cluster 10: Basophils - Unknown function" "Cluster 15: Liver - Metabolism" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 33: Fibroblasts - ECM organization" "Golgi apparatus" "HPA047415: AB_10964056, HPA061837: AB_2732672" "unprognostic (7.46e-2)" "unprognostic (1.45e-1)" "unprognostic (8.62e-2)" "unprognostic (3.43e-2)" "unprognostic (3.52e-2)" "unprognostic (1.78e-3)" "unprognostic (5.71e-2)" "unprognostic (8.21e-2)" "unprognostic (3.59e-1)" "unprognostic (9.25e-3)" "unprognostic (4.12e-2)" "unprognostic (4.98e-1)" "prognostic unfavorable (8.16e-6)" "prognostic unfavorable (8.78e-4)" "unprognostic (2.48e-1)" "unprognostic (1.74e-2)" "prognostic unfavorable (3.73e-5)" 16.9 15.8 22.1 10.8 20.5 6.0 13.4 18.4 21.6 35.4 12.3 11.1 3.2 21.8 14.3 10.8 11.2 38.1 8.5 19.4 36.7 23.1 46.0 11.5 5.9 37.2 25.0 13.5 7.8 11.0 19.5 26.4 24.7 15.1 8.0 5.2 6.8 16.4 2.7 8.2 8.7 16.2 22.9 12.0 10.9 23.0 33.8 2.1 11.3 5.6 5.3 36.8 22.1 22.5 12.1 6.5 16.5 22.4 52.7 42.0 5.7 22.3 49.8 25.7 37.1 21.9 6.6 1.4 17.7 45.1 38.9 8.9 16.2 24.8 33.3 3.5 9.3 2.3 15.1 16.5 62.3 1.8 1.9 59.5 19.0 50.2 22.1 27.8 32.7 2.9 1.0 10.2 40.2 6.2 0.1 3.1 15.5 0.4 9.6 7.8 14.6 11.4 27.3 11.5 10.4 44.5 27.8 2.1 62.2 32.4 8.6 4.7 62.3 33.1 21.3 24.2 40.6 9.2 13.3 4.7 29.6 6.8 48.2 52.2 2.3 23.9 0.8 0.1 0.8 6.1 0.5 0.6 0.3 14.0 2.2 4.1 35.2 8.8 0.0 0.0 0.0 1.9 22.1 20.5 18.4 21.6 19.4 36.7 37.2 25.0 24.7 22.9 33.8 22.5 33.8 0.0 8.9 38.8 11.5 10.8 7.7 24.4 33.6 8.5 4.0 13.3 1.6 5.7 9.6 31.3 2.1 1.8 3.8 0.2 9.8 23.0 11.2 13.3 76.5 17.9 7.7 1.3 101.9 47.6 4.3 58.5 12.2 9.7 4.5 12.2 10.0 34.1 16.2 6.7 107.1 0.8 8.2 8.9 8.9 11.6 48.1 6.2 14.2 32.8 15.8 5.0 1.0 61.3 38.8 23.7 0.1 37.2 7.1 5.3 0.0 3.2 19.5 3.6 6.6 16.4 21.6 97.1 41.3 15.1 7.5 3.8 2.8 12.6 0.7 7.7 TPST2 TANGO13B ENSG00000128294 "Tyrosylprotein sulfotransferase 2" O60704 22 26521996-26596717 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "pancreas: 398.8" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 171.0;NK-cells: 263.7;Plasma cells: 183.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HMC-1: 158.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA021054 Enhanced "Intracellular and membrane" NA NA 88000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 25: Pancreas - Digestion" "Cluster 3: HMC-1 - Innate immune response" "Cluster 55: Plasma cells - Humoral immune response" "HPA021054: AB_1858221" "unprognostic (2.24e-1)" "unprognostic (1.70e-1)" "unprognostic (1.74e-2)" "prognostic favorable (8.08e-5)" "unprognostic (8.88e-2)" "unprognostic (1.06e-1)" "unprognostic (1.19e-2)" "unprognostic (9.70e-2)" "unprognostic (3.18e-2)" "unprognostic (3.38e-1)" "unprognostic (2.70e-1)" "unprognostic (5.54e-2)" "prognostic unfavorable (2.34e-6)" "unprognostic (9.68e-2)" "unprognostic (9.21e-3)" "unprognostic (5.62e-2)" "unprognostic (2.01e-1)" 24.4 31.0 24.4 15.2 20.8 23.1 21.8 19.1 29.9 17.4 26.9 11.5 13.6 18.0 111.6 18.7 17.0 12.2 27.5 23.4 22.9 24.9 74.9 45.7 19.1 22.0 24.2 9.2 398.8 5.3 9.9 41.8 20.8 16.0 8.8 3.3 10.9 17.8 38.5 18.4 13.4 12.1 23.1 36.4 11.7 20.6 34.2 10.7 38.8 22.6 17.0 17.1 17.3 20.7 12.8 9.1 11.7 6.0 24.4 18.7 16.4 27.9 49.9 22.2 20.3 6.2 6.5 21.4 7.3 50.4 11.6 19.5 8.8 19.2 12.7 8.8 16.9 51.8 5.6 13.1 10.2 6.0 158.7 20.1 30.3 22.5 7.7 22.5 41.6 9.6 52.6 65.2 17.2 14.3 24.3 40.7 15.4 10.0 9.1 22.5 15.8 60.2 6.7 14.3 8.8 6.1 12.9 11.2 16.0 17.0 5.2 24.7 33.2 27.3 61.2 22.5 27.3 20.9 31.5 20.6 20.7 23.1 25.3 490.4 77.0 111.9 249.2 86.3 70.5 23.6 57.0 187.2 48.3 25.6 27.8 163.6 163.0 354.9 94.3 115.3 71.9 240.7 24.4 20.8 19.1 29.9 23.4 22.9 22.0 24.2 20.8 23.1 34.2 20.7 37.3 16.0 12.6 13.7 30.8 38.1 82.5 29.9 14.2 9.0 10.8 13.1 15.5 47.1 14.4 22.0 6.2 171.0 120.8 6.7 27.4 12.9 15.2 31.1 14.8 66.1 0.0 64.6 23.4 65.1 49.8 10.7 5.1 39.5 53.7 13.9 113.6 79.3 123.9 6.7 20.3 9.3 12.2 55.9 48.6 4.5 5.3 70.1 28.4 47.8 32.4 1.9 263.7 5.0 1.9 53.1 8.7 4.1 183.7 36.4 16.5 7.6 18.6 5.3 6.6 9.9 15.3 2.9 13.2 15.1 35.9 143.0 64.4 42.0 11.8 83.7 TRAF2 "RNF117, TRAP3" ENSG00000127191 "TNF receptor associated factor 2" Q12933 9 136881912-136926607 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004603, HPA009972, HPA010634" Uncertain Enhanced Cytosol NA NA "Cluster 35: T-regs - Unknown function" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 20: HeLa - Mitochondria" "Cluster 3: Monocytes - Immune response regulation" Cytosol "CAB004603: AB_628389, HPA009972: AB_1080350, HPA010634: AB_1080347" "unprognostic (7.77e-2)" "unprognostic (4.54e-3)" "prognostic unfavorable (9.32e-4)" "unprognostic (1.15e-1)" "unprognostic (1.11e-2)" "unprognostic (1.45e-1)" "prognostic unfavorable (3.06e-4)" "unprognostic (4.91e-2)" "unprognostic (7.23e-2)" "unprognostic (4.28e-2)" "unprognostic (7.39e-2)" "unprognostic (2.82e-2)" "prognostic unfavorable (2.09e-4)" "unprognostic (1.80e-3)" "unprognostic (5.52e-2)" "unprognostic (1.60e-1)" "unprognostic (1.53e-2)" 8.3 7.9 14.9 13.8 16.9 16.1 9.1 20.0 18.8 10.6 13.2 11.1 9.9 8.3 4.1 15.3 8.3 6.0 11.0 15.6 14.3 10.3 15.1 9.6 20.2 17.9 15.7 7.3 8.0 4.8 10.1 8.3 18.2 12.5 5.5 4.2 11.5 8.3 8.5 12.1 12.0 6.2 14.9 16.8 9.6 17.8 15.7 17.8 14.1 5.1 14.7 11.0 11.5 18.1 25.4 76.3 20.2 18.0 5.6 8.8 39.5 20.5 11.1 29.2 19.8 47.5 44.5 31.2 25.8 12.8 39.3 65.0 27.9 33.3 11.8 47.9 22.8 23.6 76.2 30.0 8.3 23.5 23.4 6.6 9.9 23.7 13.4 10.9 13.9 28.5 40.5 34.5 13.2 36.6 38.3 33.6 33.1 57.4 33.9 35.8 31.1 42.7 18.0 19.6 32.9 15.4 25.6 58.9 23.7 22.5 42.4 27.2 15.7 37.8 24.2 24.6 34.8 14.3 25.2 31.2 13.3 19.2 28.5 2.0 4.8 9.1 12.3 5.8 17.8 15.2 13.4 15.6 6.5 12.3 10.7 13.2 4.2 14.0 12.0 14.8 24.0 8.3 14.9 16.9 20.0 18.8 15.6 14.3 17.9 15.7 18.2 14.9 15.7 18.1 7.9 0.0 6.4 7.5 12.5 11.9 14.1 18.1 4.0 6.9 8.3 7.0 7.5 12.8 8.7 5.5 0.0 19.4 7.4 23.3 3.9 19.2 3.2 4.4 4.3 11.0 11.4 9.0 5.6 12.8 28.9 6.9 9.7 6.1 10.2 11.8 4.2 4.1 13.3 18.5 4.5 16.1 6.1 2.2 8.7 4.1 3.4 6.2 14.2 2.8 32.7 4.5 11.3 2.5 5.7 20.8 6.2 7.9 11.3 20.0 15.6 6.3 5.6 9.8 19.7 4.1 7.4 17.5 23.8 5.3 12.8 17.8 13.9 6.5 15.4 10.0 TRAF3 "CAP-1, CD40bp, CRAF1, LAP1, RNF118" ENSG00000131323 "TNF receptor associated factor 3" Q13114 14 102777449-102911500 "Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Immunity, Ubl conjugation pathway" Transferase "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 108.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA002933 Uncertain NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 2: Karpas-707 - Immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA002933: AB_1080352" "unprognostic (4.06e-2)" "unprognostic (1.75e-2)" "unprognostic (2.08e-2)" "unprognostic (4.49e-3)" "unprognostic (5.25e-2)" "unprognostic (4.17e-2)" "prognostic unfavorable (1.02e-5)" "unprognostic (1.31e-1)" "unprognostic (7.24e-2)" "unprognostic (1.16e-1)" "prognostic favorable (2.42e-5)" "unprognostic (1.29e-1)" "unprognostic (2.29e-2)" "unprognostic (1.28e-1)" "unprognostic (1.71e-1)" "unprognostic (3.13e-2)" "unprognostic (2.12e-1)" 6.6 4.2 8.3 18.8 8.7 20.5 4.8 6.3 14.5 3.9 7.6 7.9 7.7 5.8 2.3 6.6 6.8 6.2 6.3 15.6 12.1 5.4 6.4 7.3 20.9 9.8 9.9 3.3 4.5 7.2 8.4 3.9 9.5 5.0 6.3 4.4 4.8 5.7 5.6 6.8 10.7 6.4 8.1 12.0 6.7 10.7 12.8 9.4 6.1 3.3 15.9 8.8 4.7 8.0 25.3 26.4 14.8 9.7 7.5 11.4 23.4 19.1 19.0 19.1 16.7 13.3 36.7 18.6 22.5 19.2 25.8 14.9 20.4 20.4 19.1 50.2 13.9 18.2 11.7 10.3 12.0 21.4 54.5 11.4 13.9 13.1 18.3 10.9 13.9 27.8 18.2 57.4 11.8 23.6 46.2 12.6 8.0 10.7 19.2 25.5 19.8 11.7 16.8 29.3 38.3 13.8 19.8 14.1 13.0 6.6 13.1 24.2 29.9 18.0 14.8 48.0 27.8 42.2 51.7 36.0 20.5 10.8 21.8 3.3 5.1 1.8 2.9 4.0 2.4 10.0 4.2 2.6 3.6 9.5 3.0 2.1 3.8 2.4 2.5 5.9 3.8 5.0 8.3 8.7 6.3 14.5 15.6 12.1 9.8 9.9 9.5 8.1 12.8 8.0 4.2 6.4 8.9 54.5 43.3 12.2 20.4 20.0 18.2 42.6 9.1 6.9 8.0 10.0 13.8 0.0 6.2 5.3 12.8 14.9 3.9 15.8 9.7 20.2 13.5 8.6 17.4 2.1 108.3 17.8 11.7 11.2 8.6 12.2 8.2 3.5 1.4 5.3 12.9 15.2 63.1 15.8 10.2 8.7 29.5 7.6 1.8 20.3 17.8 23.4 18.1 5.4 8.2 63.8 43.6 22.6 5.9 6.4 42.1 28.8 16.9 8.3 19.2 11.0 0.0 12.2 8.4 14.2 33.2 12.7 12.6 3.4 21.9 1.5 11.3 24.9 TRAF3IP2 "ACT1, C6orf2, C6orf4, C6orf5, C6orf6, CIKS, DKFZP586G0522" ENSG00000056972 "TRAF3 interacting protein 2" O43734 6 111555381-111606906 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Inflammatory response, Ubl conjugation pathway" Transferase "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal prostatic cells: 61.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "U-2197: 149.7" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" HPA036352 Approved Approved "Golgi apparatus,Vesicles" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 68: Epididymis - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 22: Epithelial cell types - Mixed function" "Golgi apparatus" Vesicles "HPA036352: AB_10672085" "unprognostic (1.94e-1)" "prognostic unfavorable (3.21e-4)" "unprognostic (1.79e-1)" "prognostic favorable (4.73e-5)" "unprognostic (2.81e-2)" "unprognostic (3.03e-2)" "unprognostic (1.01e-2)" "unprognostic (9.93e-2)" "unprognostic (2.10e-1)" "unprognostic (1.13e-2)" "unprognostic (2.64e-2)" "unprognostic (1.05e-2)" "prognostic unfavorable (5.16e-5)" "unprognostic (1.11e-1)" "unprognostic (4.88e-1)" "unprognostic (2.34e-2)" "unprognostic (1.31e-1)" 19.7 16.3 24.8 19.5 24.8 32.4 19.9 24.3 29.4 24.9 23.7 34.0 28.6 36.2 47.2 26.5 34.7 14.2 8.3 24.4 26.0 9.3 8.6 17.5 16.3 27.2 28.2 13.9 21.6 13.6 9.3 14.2 25.6 19.2 26.4 5.9 25.3 30.8 11.4 35.0 25.1 22.1 21.7 6.8 35.5 3.0 28.7 21.0 14.8 14.8 22.5 26.5 18.1 22.9 32.2 11.0 6.8 15.7 35.9 39.0 15.6 39.8 62.2 9.9 14.1 8.7 14.1 6.2 13.2 33.5 35.5 58.2 8.0 86.2 18.4 43.2 11.6 12.7 10.6 11.9 13.9 6.9 22.6 47.1 57.5 29.9 110.1 24.9 20.0 15.2 13.6 1.9 13.2 22.0 51.2 19.4 9.0 30.6 8.8 53.3 12.4 2.7 29.5 52.4 27.3 6.9 12.1 71.8 47.8 12.7 31.6 18.0 9.2 19.2 7.6 149.7 35.5 0.8 12.4 16.8 45.8 10.8 50.1 25.8 2.5 5.3 3.8 0.8 12.7 6.4 7.6 5.6 2.6 8.6 7.6 7.4 3.5 5.7 0.3 0.8 17.9 3.1 24.8 24.8 24.3 29.4 24.4 26.0 27.2 28.2 25.6 21.7 28.7 22.9 24.7 3.2 13.8 26.1 10.8 30.1 61.5 46.3 11.4 7.5 8.3 8.6 4.9 7.2 21.6 3.7 12.5 19.3 3.8 30.0 5.9 35.4 0.1 20.9 14.5 18.3 13.2 5.2 5.9 31.9 28.8 14.4 18.3 32.7 20.2 7.7 3.9 5.5 6.0 6.7 10.8 16.9 16.2 1.3 10.7 0.5 7.2 5.8 12.4 7.5 6.2 14.2 8.2 19.6 6.6 20.2 26.3 7.5 4.5 42.9 18.5 5.9 18.3 5.5 0.0 14.7 10.5 0.8 2.1 16.2 24.6 20.9 7.9 4.6 21.9 45.0 TRAF6 RNF85 ENSG00000175104 "TNF receptor associated factor 6" Q9Y4K3 11 36483769-36510272 "Enzymes, Predicted intracellular proteins" "DNA damage, Immunity, Osteogenesis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004605, HPA019805, HPA020599" Approved Uncertain Nucleoli,Mitochondria NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 59: Non-specific - Transcription" Mitochondria Nucleoli "CAB004605: AB_628391, HPA019805: AB_1858231, HPA020599: AB_1858232" "unprognostic (2.48e-2)" "unprognostic (1.38e-1)" "unprognostic (2.83e-1)" "unprognostic (8.73e-2)" "unprognostic (1.71e-1)" "unprognostic (1.55e-1)" "unprognostic (2.43e-1)" "unprognostic (2.10e-1)" "unprognostic (1.40e-1)" "unprognostic (1.21e-1)" "unprognostic (1.16e-2)" "unprognostic (9.22e-2)" "prognostic favorable (1.36e-4)" "unprognostic (2.82e-2)" "unprognostic (1.20e-1)" "unprognostic (3.92e-2)" "unprognostic (1.07e-1)" 6.5 5.1 4.3 5.3 5.2 23.3 5.8 4.6 5.8 6.1 4.7 5.7 6.0 6.4 5.7 6.4 6.2 5.7 7.5 4.8 4.4 6.7 7.9 7.9 6.3 4.7 4.5 7.9 7.2 6.0 4.0 6.2 4.5 5.0 6.3 5.4 5.9 5.4 7.0 6.4 7.6 7.5 3.7 8.4 5.7 7.8 4.8 9.5 9.6 8.0 7.1 5.5 6.2 6.5 5.1 6.3 12.0 6.8 11.0 7.9 5.1 7.5 8.0 6.8 8.8 5.6 3.3 6.7 4.5 8.0 7.8 9.4 9.6 7.6 11.2 11.0 11.1 6.4 5.0 5.0 7.1 7.2 7.5 7.5 10.5 3.6 11.1 6.6 9.7 8.7 9.7 7.1 8.7 6.2 11.6 4.0 6.5 5.8 5.7 7.5 16.2 3.8 8.2 10.4 1.9 10.4 7.5 7.1 5.3 8.0 8.3 6.9 7.7 9.6 8.5 8.9 9.2 8.2 7.4 7.1 5.4 5.0 7.3 59.5 12.4 34.6 17.8 17.9 17.4 17.1 15.0 17.5 12.3 13.6 14.5 19.0 17.5 16.2 13.7 7.2 13.2 14.5 4.3 5.2 4.6 5.8 4.8 4.4 4.7 4.5 4.5 3.7 4.8 6.5 9.1 9.6 5.1 13.1 12.1 12.7 13.8 6.5 6.8 2.7 5.3 3.6 7.0 7.2 4.0 3.7 6.2 6.6 12.3 8.1 5.9 8.7 7.3 6.3 6.3 12.1 4.2 7.4 29.0 7.2 6.2 6.5 6.6 10.4 19.0 5.5 19.2 6.0 7.2 8.4 24.0 5.8 8.2 8.5 13.6 3.4 2.5 7.8 7.2 17.8 9.1 4.6 8.2 11.1 29.1 7.9 8.2 4.1 10.8 10.4 10.0 5.5 3.1 2.9 13.1 6.6 9.5 15.2 9.3 8.0 12.5 6.4 10.9 4.4 3.9 11.6 TRAF7 "DKFZp586I021, MGC7807, RFWD1, RNF119" ENSG00000131653 "TNF receptor associated factor 7" Q6Q0C0 16 2155698-2178129 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Apoptosis, Transcription, Transcription regulation, Ubl conjugation pathway" Transferase "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041229 Approved Supported "Vesicles,Plasma membrane" NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 7: Non-specific - Mitochondria" Vesicles "Plasma membrane" "HPA041229: AB_10794194" "unprognostic (1.94e-1)" "unprognostic (5.97e-2)" "unprognostic (1.13e-1)" "unprognostic (4.23e-2)" "unprognostic (1.09e-1)" "unprognostic (1.03e-1)" "unprognostic (1.65e-2)" "unprognostic (2.77e-3)" "unprognostic (7.08e-2)" "unprognostic (3.52e-2)" "unprognostic (1.52e-2)" "unprognostic (1.08e-1)" "unprognostic (9.23e-2)" "unprognostic (6.07e-2)" "unprognostic (2.99e-2)" "unprognostic (2.43e-1)" "unprognostic (8.48e-2)" 29.1 29.4 16.5 24.4 15.1 35.0 28.2 18.2 23.0 32.1 17.0 38.0 40.0 31.2 11.6 54.6 30.4 22.2 21.3 17.9 14.6 28.1 51.5 33.2 22.9 17.8 15.3 23.5 37.4 14.6 32.1 20.6 14.8 27.0 17.4 8.5 34.7 16.5 30.4 47.7 35.2 18.8 14.2 34.5 35.6 14.8 17.7 19.1 25.6 9.9 18.6 34.5 34.8 14.3 57.7 72.2 40.3 72.5 40.8 76.5 47.4 43.4 53.9 49.9 44.6 88.2 72.1 36.6 50.2 55.4 31.8 65.9 38.1 76.8 18.8 58.3 48.8 52.4 98.5 68.3 53.8 56.3 72.7 76.2 62.8 48.1 62.6 41.0 97.4 70.6 57.1 47.9 48.2 131.1 58.3 65.2 79.7 78.7 34.8 107.4 66.7 74.2 40.2 30.4 80.9 67.2 36.3 68.5 48.6 20.9 78.1 68.2 74.3 60.2 83.9 56.7 48.2 69.2 55.0 48.4 34.4 35.9 47.8 4.0 9.1 7.3 4.5 12.4 4.3 5.5 4.4 4.7 11.2 3.9 3.1 3.8 6.2 2.9 8.9 5.3 6.5 5.3 16.5 15.1 18.2 23.0 17.9 14.6 17.8 15.3 14.8 14.2 17.7 14.3 18.9 0.0 9.2 12.4 18.2 28.8 21.1 34.2 22.8 15.9 31.6 27.9 4.9 21.5 20.8 14.7 6.2 23.5 17.4 56.4 17.6 39.0 5.0 23.6 34.6 26.5 34.0 33.6 8.9 59.0 36.3 19.0 38.7 27.9 9.5 22.1 26.0 32.3 42.2 37.0 8.2 38.7 34.6 41.8 21.3 13.1 24.8 26.8 10.6 8.4 33.9 12.6 6.2 6.6 4.9 53.0 43.6 22.2 24.0 33.8 80.0 29.2 19.7 10.9 6.6 11.9 18.3 8.5 25.3 50.7 32.5 26.7 16.0 29.0 42.5 38.5 TRAIP "RNF206, TRIP" ENSG00000183763 "TRAF interacting protein" Q9BWF2 3 49828601-49856574 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Disease variant, Dwarfism, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 8.2;Spermatocytes: 15.6;Spermatogonia: 9.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Region enhanced" "Detected in many" "basal ganglia: 10.8" "HPA036261, HPA036262" Enhanced Supported "Plasma membrane,Cytosol" NA NA "Cluster 37: B-cells - Transcription" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" "Plasma membrane, Cytosol" "HPA036261: AB_10673348, HPA036262: AB_2675029" "unprognostic (5.30e-3)" "unprognostic (9.41e-2)" "unprognostic (1.48e-1)" "unprognostic (6.50e-3)" "unprognostic (1.88e-1)" "unprognostic (7.68e-3)" "prognostic unfavorable (8.77e-5)" "unprognostic (4.61e-2)" "unprognostic (1.52e-2)" "unprognostic (8.61e-2)" "unprognostic (1.24e-2)" "unprognostic (7.97e-2)" "unprognostic (9.01e-5)" "unprognostic (5.84e-2)" "unprognostic (4.24e-1)" "unprognostic (1.78e-1)" "unprognostic (1.24e-1)" 1.5 1.0 1.6 1.8 2.5 6.8 1.9 0.7 1.8 2.0 0.4 2.3 1.5 1.7 1.4 2.9 1.8 1.0 0.9 1.6 0.9 0.8 0.8 0.9 4.6 0.6 0.6 2.1 1.0 0.8 1.2 1.6 0.7 1.4 2.9 2.3 1.2 0.9 2.0 4.2 2.0 2.1 0.6 1.9 1.2 7.9 1.3 5.3 1.4 1.2 4.4 1.3 1.9 0.9 10.4 12.4 17.4 17.6 1.6 2.4 14.4 12.4 5.8 25.3 24.0 15.2 11.6 25.5 8.5 7.1 17.7 13.4 18.5 14.0 18.8 14.7 12.2 19.2 16.3 13.6 0.7 15.8 15.4 1.6 2.0 20.4 10.7 3.0 6.7 22.3 14.0 17.8 11.4 15.1 26.5 20.1 14.0 12.3 20.3 14.4 11.7 14.8 4.6 14.2 8.4 14.4 13.6 11.3 8.8 12.4 10.2 22.4 5.2 16.1 19.0 22.5 24.4 13.0 33.7 27.3 8.1 21.2 14.6 0.0 0.6 0.3 0.9 0.3 0.9 2.9 0.5 2.1 0.6 1.5 0.7 1.1 0.1 1.2 1.3 0.7 0.3 0.6 1.6 2.5 0.7 1.8 1.6 0.9 0.6 0.6 0.7 0.6 1.3 0.9 0.6 3.2 0.6 1.0 1.8 1.1 0.6 1.5 2.2 2.8 1.2 1.4 2.6 0.0 0.3 3.7 0.0 4.2 1.2 1.8 0.0 2.0 4.3 0.6 0.9 0.8 0.0 3.8 1.4 1.0 8.2 2.0 1.5 0.9 0.0 5.7 1.1 0.7 3.5 0.0 0.9 2.0 0.0 0.8 0.4 4.8 2.5 0.7 1.8 1.0 1.8 1.7 0.0 0.5 0.6 1.1 0.3 1.2 4.3 0.8 0.9 0.3 0.5 3.3 0.0 1.4 1.7 15.6 9.1 2.3 0.3 1.0 1.2 1.2 4.6 0.2 TRDMT1 "DNMT2, RNMT1" ENSG00000107614 "TRNA aspartic acid methyltransferase 1" O14717 10 17137336-17202054 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "tRNA processing" "Methyltransferase, RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Astrocytes: 29.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "MOLT-4: 14.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009468, HPA036945, HPA036946" Approved NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 21: Non-specific - Transcription" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 59: Non-specific - Transcription" "CAB009468: AB_2208432, HPA036945: AB_2675398, HPA036946: AB_2675399" "unprognostic (4.55e-1)" "unprognostic (3.22e-2)" "unprognostic (4.49e-6)" "unprognostic (7.07e-2)" "unprognostic (3.87e-3)" "unprognostic (1.33e-1)" "unprognostic (3.27e-4)" "unprognostic (3.28e-3)" "unprognostic (1.09e-1)" "unprognostic (1.65e-1)" "unprognostic (1.55e-1)" "unprognostic (2.65e-2)" "unprognostic (3.50e-2)" "unprognostic (1.44e-1)" "unprognostic (1.60e-1)" "unprognostic (1.40e-1)" "unprognostic (2.64e-2)" 1.8 1.5 1.4 1.3 2.3 1.5 1.8 4.5 1.6 1.7 1.9 1.2 0.8 2.7 4.6 1.2 2.0 2.0 1.4 1.5 1.1 2.1 0.7 1.4 2.2 2.5 2.0 3.0 1.5 2.6 1.3 1.5 3.2 1.3 1.0 5.8 1.5 0.9 1.2 1.6 1.3 1.1 1.6 1.3 1.5 1.2 1.5 3.3 3.7 0.2 1.9 1.1 1.5 1.4 3.6 1.3 7.7 1.3 2.3 1.1 0.0 4.0 2.0 4.0 4.0 3.2 3.5 2.1 0.5 1.5 5.7 1.9 3.7 2.0 2.6 5.4 1.6 2.4 3.3 1.8 0.6 2.8 3.1 2.0 1.6 1.7 1.6 2.6 2.6 6.1 3.8 2.7 4.6 0.8 14.6 0.9 4.1 1.1 1.3 2.6 5.3 1.3 0.7 2.4 1.7 2.3 0.0 1.7 2.1 3.3 2.9 2.3 0.9 1.9 5.1 4.7 3.0 3.1 4.1 7.0 2.5 3.2 1.9 4.9 2.5 1.2 2.2 1.7 4.2 3.4 3.8 2.8 3.2 3.5 4.9 3.4 1.6 2.6 0.9 7.0 1.3 2.0 1.4 2.3 4.5 1.6 1.5 1.1 2.5 2.0 3.2 1.6 1.5 1.4 6.5 6.4 4.8 29.4 9.1 3.3 2.1 3.5 4.6 12.2 2.6 2.8 5.5 2.8 6.1 3.7 4.2 2.1 7.1 2.1 5.9 4.4 6.7 8.1 5.9 6.2 0.0 6.9 21.8 4.9 2.5 5.8 5.6 5.9 12.7 10.2 4.2 1.7 5.1 16.8 23.2 1.2 4.1 5.0 7.0 6.7 6.5 5.8 0.0 8.4 5.4 12.1 7.2 23.6 14.9 2.5 1.7 6.4 10.2 1.1 2.5 5.0 7.5 17.3 0.0 7.7 7.6 12.5 6.1 4.8 3.1 1.8 10.4 7.6 3.1 1.2 TRIM11 "BIA1, RNF92" ENSG00000154370 "Tripartite motif containing 11" Q96F44 1 228393673-228406835 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Antiviral defense, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 154.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028541, HPA043879" Approved Enhanced Nucleoplasm,Cytosol NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 18: Non-specific - Mitochondria" "Cluster 28: BEWO - Transcription regulation" "Cluster 29: Early spermatids - Spermatogenesis" "Nucleoplasm, Cytosol" "HPA028541: AB_10600833, HPA043879: AB_2678711" "unprognostic (1.73e-1)" "unprognostic (9.73e-3)" "unprognostic (5.48e-3)" "unprognostic (7.73e-2)" "unprognostic (3.27e-1)" "unprognostic (2.33e-1)" "prognostic unfavorable (7.42e-5)" "unprognostic (1.08e-1)" "unprognostic (9.74e-2)" "unprognostic (2.04e-1)" "unprognostic (1.40e-1)" "unprognostic (3.15e-1)" "prognostic unfavorable (1.62e-4)" "unprognostic (3.40e-2)" "unprognostic (4.89e-2)" "unprognostic (2.04e-1)" "unprognostic (1.22e-2)" 10.2 12.1 12.7 8.9 16.0 30.7 10.4 23.9 15.2 14.7 10.1 13.6 7.7 11.5 4.5 20.7 12.7 6.1 8.7 14.4 11.6 12.2 10.2 11.8 12.2 11.6 9.9 11.9 11.9 6.7 9.8 5.6 10.8 15.4 7.1 2.0 17.1 7.0 5.0 17.1 14.6 4.6 8.6 24.1 12.9 14.9 13.2 10.1 11.0 3.1 8.7 11.7 15.6 11.0 28.3 26.3 13.8 19.1 10.2 8.4 65.1 18.1 12.1 20.5 16.4 32.2 24.0 21.1 19.7 12.2 13.5 45.1 16.8 17.4 8.6 23.6 40.5 17.5 26.7 17.6 27.6 22.2 25.6 11.3 27.2 21.3 10.6 10.5 10.2 33.9 40.7 26.4 10.7 18.2 27.1 35.1 35.3 23.9 22.9 26.3 12.5 25.8 13.4 34.0 22.9 42.0 15.1 42.2 24.7 5.6 29.9 36.8 11.6 13.0 18.3 30.6 37.9 26.9 19.3 18.9 16.1 17.7 20.9 5.2 4.5 5.6 5.5 5.3 5.9 3.7 6.4 7.1 4.4 3.5 3.6 5.1 6.2 6.2 7.5 3.5 6.4 3.9 12.7 16.0 23.9 15.2 14.4 11.6 11.6 9.9 10.8 8.6 13.2 11.0 7.8 3.2 5.8 1.6 12.1 15.8 16.3 7.4 10.8 12.1 13.3 10.7 3.6 12.8 10.4 1.8 2.1 15.7 21.6 28.1 17.6 14.8 154.2 11.2 10.2 10.1 14.4 12.6 9.8 11.0 15.5 8.5 23.4 17.1 5.7 13.4 8.9 5.7 11.8 5.0 4.7 21.7 4.1 12.6 9.3 16.5 9.6 11.0 5.4 2.8 22.0 10.3 30.9 3.0 3.2 18.3 21.1 7.5 12.8 17.4 17.8 9.9 7.3 1.6 6.6 8.4 9.1 7.3 12.4 15.8 19.5 57.3 18.9 14.9 17.6 30.1 TRIM13 "DLEU5, Leu5, RFP2, RNF77" ENSG00000204977 "Tripartite motif containing 13" O60858 13 49995888-50020481 "Enzymes, Predicted intracellular proteins, Predicted membrane proteins" "Immunity, Innate immunity, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 4 "Early spermatids: 576.8;Spermatocytes: 211.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000367 Enhanced NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 14: REH - Unknown function" "Cluster 23: Spermatids - Flagellum & Golgi organization" "HPA000367: AB_1856196" "unprognostic (1.14e-1)" "unprognostic (8.22e-2)" "unprognostic (6.14e-2)" "unprognostic (2.23e-3)" "unprognostic (4.75e-3)" "unprognostic (5.01e-2)" "unprognostic (4.60e-2)" "unprognostic (2.83e-2)" "unprognostic (2.59e-2)" "unprognostic (2.38e-2)" "unprognostic (2.44e-1)" "unprognostic (5.07e-1)" "unprognostic (7.28e-3)" "unprognostic (4.66e-2)" "unprognostic (9.01e-2)" "unprognostic (2.37e-2)" "unprognostic (1.55e-2)" 18.0 13.7 12.8 14.7 18.1 65.2 21.0 21.7 14.7 17.0 10.1 18.1 12.7 16.6 14.9 26.6 17.2 12.6 16.6 11.8 14.3 22.0 14.3 20.8 20.2 15.2 14.2 19.3 15.5 20.2 15.7 14.9 15.4 20.1 20.1 15.8 19.0 13.1 24.9 27.0 18.7 14.0 13.6 20.9 15.3 79.0 15.1 24.1 15.9 24.3 23.2 15.5 18.9 24.3 10.6 12.0 41.3 32.1 22.7 35.3 18.7 17.0 24.5 13.5 9.4 16.6 23.7 38.9 5.2 18.6 12.2 16.2 18.4 22.5 16.6 15.1 16.2 38.7 9.9 18.9 25.3 37.5 21.7 25.9 32.5 12.4 20.6 34.0 30.3 32.9 21.0 12.0 27.0 9.6 31.5 58.5 37.5 24.3 9.0 37.7 1.9 11.7 28.8 17.2 16.5 26.9 15.4 15.8 24.8 29.1 17.9 46.9 28.5 13.9 12.8 11.5 9.7 8.6 7.8 28.6 6.2 16.9 19.2 24.8 17.7 28.4 19.0 15.8 24.1 46.4 25.5 25.2 22.7 45.4 22.3 20.9 35.0 27.0 23.5 34.8 30.0 14.4 12.8 18.1 21.7 14.7 11.8 14.3 15.2 14.2 15.4 13.6 15.1 24.3 34.2 25.6 29.1 20.9 47.7 27.5 37.0 48.8 21.1 24.5 24.8 19.2 20.1 22.8 39.8 27.6 20.9 33.4 31.7 24.2 19.6 25.4 576.8 21.3 25.3 29.8 44.9 20.6 30.6 20.1 16.5 26.2 15.8 15.3 38.7 34.1 20.3 15.1 18.3 11.8 29.6 27.5 30.5 21.3 62.3 83.6 25.7 24.3 17.8 35.6 27.1 14.5 28.8 45.8 57.5 20.3 22.7 29.7 13.8 34.5 21.5 32.8 51.8 54.3 19.7 25.2 29.9 211.2 25.2 29.9 33.4 32.2 29.0 21.3 28.6 31.1 TRIM16 EBBP ENSG00000221926 "Tripartite motif containing 16" O95361 17 15627960-15684311 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "esophagus: 145.9" "Cell type enhanced" "Detected in many" "Pancreatic endocrine cells: 153.4;Squamous epithelial cells: 95.5;Urothelial cells: 111.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 9 "T-reg: 45.1" "Lineage enriched" "Detected in many" 12 "T-cells: 45.1" "Cell line enhanced" "Detected in all" "A549: 283.8;HaCaT: 229.0;HeLa: 203.8;OE19: 364.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA023623, HPA066431" Uncertain Supported "Plasma membrane,Cytosol" NA NA 19000 "Cluster 4: T-regs - Cell cycle regulation" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 21: OE19 - Mitochondria" "Cluster 61: Squamous epithelial cells - Keratinization" Cytosol "Plasma membrane" "HPA023623: AB_1858273, HPA066431: AB_2685668" "unprognostic (2.14e-1)" "unprognostic (1.95e-1)" "unprognostic (9.61e-2)" "unprognostic (1.31e-2)" "unprognostic (6.19e-2)" "unprognostic (1.21e-1)" "prognostic unfavorable (3.94e-4)" "unprognostic (1.94e-3)" "unprognostic (3.75e-2)" "unprognostic (4.65e-1)" "unprognostic (3.31e-3)" "unprognostic (1.70e-1)" "unprognostic (2.16e-3)" "unprognostic (2.08e-1)" "unprognostic (8.48e-2)" "unprognostic (9.21e-3)" "prognostic unfavorable (6.71e-4)" 18.3 32.7 14.1 7.8 16.2 17.4 13.4 17.7 21.5 44.9 10.3 14.1 22.8 6.1 4.9 145.9 8.8 16.3 23.1 13.5 15.8 8.5 5.9 14.5 9.7 16.9 16.0 7.3 6.0 3.6 4.4 34.5 17.2 10.2 11.2 3.6 38.0 11.7 28.1 44.9 12.5 9.0 15.8 6.0 31.7 12.7 17.2 10.1 18.7 27.2 37.3 35.7 70.2 22.1 91.5 283.8 8.6 19.4 40.4 46.1 9.6 14.8 51.9 17.9 25.0 17.2 115.6 9.8 54.7 64.7 106.9 229.0 25.6 65.7 12.0 120.0 16.4 4.5 203.8 9.5 67.1 5.4 9.6 25.7 40.9 39.3 22.3 49.6 38.8 11.4 5.7 45.8 49.2 32.2 20.2 11.7 13.1 364.2 17.0 8.7 71.8 6.9 92.4 116.0 6.4 17.7 64.7 72.2 22.1 49.7 10.9 12.6 61.0 22.5 26.3 10.9 51.3 11.1 12.9 1.0 34.6 12.6 58.3 0.4 3.8 1.0 1.2 1.1 0.8 0.5 4.9 1.5 2.6 0.6 1.3 2.6 0.6 0.9 0.5 0.4 45.1 2.3 14.1 16.2 17.7 21.5 13.5 15.8 16.9 16.0 17.2 15.8 17.2 22.1 34.9 38.5 2.6 14.0 5.3 30.8 59.0 55.6 10.2 7.2 11.8 5.7 12.5 10.0 73.5 11.0 18.8 13.6 2.8 9.9 0.0 49.1 1.1 16.5 9.9 28.7 4.2 9.0 9.6 17.3 8.4 9.6 34.7 25.7 4.5 12.4 3.6 3.2 4.0 3.3 14.0 21.7 28.5 2.9 8.6 3.9 7.2 2.9 7.2 11.2 13.0 6.6 4.1 18.6 19.2 153.4 26.9 4.5 3.7 29.5 4.3 6.2 33.5 8.4 6.6 5.8 14.0 10.3 12.1 95.5 77.6 4.7 5.9 60.9 18.4 111.9 TRIM17 "RBCC, RNF16, terf" ENSG00000162931 "Tripartite motif containing 17" Q9Y577 1 228407935-228416861 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 4 "testis: 42.0" "Group enriched" "Detected in some" 27 "Early spermatids: 291.1;Late spermatids: 87.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 4.4;HEL: 2.1;NTERA-2: 1.9;SH-SY5Y: 2.3;T-47d: 5.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in single" HPA054908 Approved Approved Vesicles NA NA "Cluster 24: B-cells - Unknown function" "Cluster 78: Testis - Spermatogenesis" "Cluster 6: T47d - Mammary gland" "Cluster 29: Early spermatids - Spermatogenesis" Vesicles "HPA054908: AB_2682638" "prognostic favorable (1.86e-4)" "unprognostic (2.12e-1)" "unprognostic (3.06e-2)" "unprognostic (5.45e-2)" "unprognostic (1.25e-1)" "unprognostic (7.74e-3)" "unprognostic (7.42e-3)" "unprognostic (2.02e-1)" "unprognostic (1.17e-2)" "unprognostic (8.91e-2)" "unprognostic (2.23e-1)" "unprognostic (2.04e-1)" "unprognostic (5.96e-4)" "unprognostic (3.88e-1)" "unprognostic (4.88e-2)" "unprognostic (6.33e-2)" "unprognostic (3.64e-1)" 2.1 1.2 3.2 0.3 6.3 0.2 2.9 10.2 4.9 3.0 1.1 0.6 0.2 2.0 0.4 1.9 3.9 0.4 1.7 4.8 1.4 3.0 0.2 1.5 0.6 1.3 0.9 3.2 0.6 1.6 2.1 0.3 0.8 4.1 0.0 0.2 4.6 0.7 0.1 2.2 1.0 0.2 0.0 6.4 1.0 42.0 2.6 0.0 3.1 0.0 0.2 1.6 3.2 1.0 0.1 0.4 0.2 0.2 0.0 0.0 4.4 0.3 0.0 0.0 0.0 1.0 0.5 0.0 1.0 0.0 0.1 1.1 0.0 0.0 0.1 0.1 0.4 2.1 0.7 0.1 0.8 0.0 0.2 0.1 0.1 0.0 0.0 0.1 0.0 0.3 0.1 0.3 0.0 0.1 0.2 0.0 1.9 0.0 0.1 0.1 0.0 0.0 0.0 0.4 0.3 2.3 0.0 0.2 0.0 0.4 5.6 0.1 0.0 0.2 0.9 0.2 0.0 0.0 0.0 0.1 0.1 0.1 0.2 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.3 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.0 3.2 6.3 10.2 4.9 4.8 1.4 1.3 0.9 0.8 0.0 2.6 1.0 0.0 0.0 0.5 0.3 0.1 0.3 1.7 0.1 2.8 1.0 0.6 0.9 1.5 0.0 1.5 1.8 0.0 0.0 0.9 0.1 0.0 0.7 291.1 1.2 1.3 0.3 0.0 0.0 7.0 0.0 0.0 1.1 0.0 0.8 0.0 0.3 0.0 0.0 0.1 0.0 1.2 0.0 0.0 0.0 0.0 87.9 1.2 0.1 0.0 1.0 0.0 0.5 1.0 0.5 0.9 0.6 0.0 0.4 0.1 0.7 0.0 0.0 2.4 0.0 0.0 0.1 0.3 2.5 1.8 0.2 0.3 0.8 0.9 0.0 0.0 0.6 TRIM2 "CMT2R, KIAA0517, RNF86" ENSG00000109654 "Tripartite motif containing 2" Q9C040 4 153152163-153339319 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Charcot-Marie-Tooth disease, Disease variant, Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 116.2" "Cell type enriched" "Detected in many" 4 "Oligodendrocytes: 1132.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "memory CD4 T-cell: 1.0" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "AF22: 47.0;SK-MEL-30: 46.8" "HPA035853, HPA035854" Supported Uncertain Centrosome NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 45: Intestine - Brush border" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Centrosome "HPA035853: AB_10669533, HPA035854: AB_10669659" "unprognostic (8.94e-2)" "unprognostic (7.89e-2)" "unprognostic (6.21e-3)" "unprognostic (7.51e-3)" "unprognostic (2.07e-2)" "unprognostic (2.32e-1)" "unprognostic (1.16e-2)" "unprognostic (2.30e-3)" "unprognostic (5.30e-2)" "unprognostic (6.77e-2)" "unprognostic (1.93e-2)" "unprognostic (1.42e-2)" "prognostic favorable (6.58e-14)" "unprognostic (5.89e-2)" "unprognostic (1.17e-2)" "unprognostic (4.19e-2)" "unprognostic (4.13e-2)" 5.8 11.8 29.5 4.8 64.4 0.1 11.8 38.6 46.2 23.6 0.0 21.6 17.4 9.9 8.0 10.7 15.2 12.6 8.4 48.0 34.8 24.2 7.9 7.2 2.2 40.1 33.2 12.8 12.7 1.0 21.6 2.5 56.3 13.1 19.3 19.4 42.9 13.4 2.1 7.1 17.3 7.0 35.3 10.6 27.4 1.9 37.9 2.9 50.6 3.0 3.9 12.0 11.5 116.2 10.2 0.2 47.0 24.2 22.0 27.2 0.5 12.7 15.4 3.6 4.5 4.1 0.2 0.1 7.7 21.7 8.5 6.4 24.7 4.7 3.2 0.0 5.4 0.1 4.6 0.5 24.7 0.1 0.1 13.5 2.3 5.4 4.7 12.9 3.4 0.4 0.2 0.0 4.9 0.4 2.4 0.1 37.4 27.5 8.8 1.0 9.4 0.0 37.0 11.8 14.5 27.3 4.4 2.7 46.8 6.9 1.7 0.5 2.8 12.7 3.0 10.8 3.9 0.0 0.0 0.1 20.9 0.0 20.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 1.0 0.0 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.8 0.1 29.5 64.4 38.6 46.2 48.0 34.8 40.1 33.2 56.3 35.3 37.9 116.2 11.2 6.4 33.7 189.0 2.6 7.0 15.3 40.2 9.1 67.7 40.5 29.1 39.6 17.2 82.1 58.8 29.2 2.0 0.7 59.4 101.8 9.6 3.3 113.3 16.3 17.3 62.3 0.4 266.4 26.1 0.5 22.0 80.0 95.6 1.3 4.8 21.0 12.4 1.4 111.0 211.2 64.1 54.9 0.8 7.7 2.4 29.5 2.2 64.0 21.5 3.2 86.9 0.0 237.2 1132.8 22.5 41.4 32.7 1.5 17.8 62.9 14.7 106.0 23.4 26.3 14.7 16.2 0.4 1.3 5.0 4.0 0.7 2.8 8.7 90.8 33.7 TRIM21 "RNF81, RO52, SSA1" ENSG00000132109 "Tripartite motif containing 21" P19474 11 4384897-4393702 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Ubl conjugation pathway" "DNA-binding, Ribonucleoprotein, RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004566, HPA005673" Enhanced Approved Nucleoplasm NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 64: Macrophages - Immune response" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 63: NK-cells & T-cells - Immune response" Nucleoplasm "CAB004566: AB_628286, HPA005673: AB_1080090" "prognostic favorable (4.83e-5)" "unprognostic (4.55e-2)" "unprognostic (3.64e-2)" "unprognostic (3.01e-2)" "unprognostic (1.50e-1)" "unprognostic (1.43e-1)" "prognostic unfavorable (1.87e-4)" "unprognostic (1.20e-1)" "unprognostic (5.04e-2)" "unprognostic (1.27e-1)" "unprognostic (2.49e-2)" "unprognostic (3.31e-1)" "unprognostic (1.82e-2)" "unprognostic (6.27e-2)" "unprognostic (4.69e-2)" "prognostic favorable (2.26e-6)" "unprognostic (9.12e-3)" 14.1 13.0 6.1 21.6 6.0 27.7 11.9 5.9 8.0 11.9 7.2 17.1 20.3 12.5 13.0 12.0 14.6 12.9 13.1 5.5 6.8 16.3 17.6 23.5 23.8 8.2 6.3 20.6 11.7 6.8 7.1 14.4 7.0 11.3 18.4 2.4 19.5 12.9 5.5 11.4 19.2 17.9 7.8 32.5 15.5 3.5 7.8 21.8 10.0 8.2 23.2 16.7 10.9 7.2 13.5 15.5 7.7 7.3 15.5 23.1 10.7 16.8 31.7 64.6 71.4 7.2 37.6 20.5 7.5 25.0 66.5 18.4 13.6 25.7 20.1 34.5 14.6 31.6 8.5 6.5 34.3 37.3 29.6 22.7 14.9 13.0 9.2 23.3 40.3 17.3 10.1 21.6 21.9 11.9 19.8 26.5 6.6 14.9 8.0 13.8 10.0 10.9 25.6 12.0 0.1 3.3 13.8 14.9 19.1 12.0 5.3 24.5 36.7 15.6 12.3 8.3 6.1 11.4 9.5 13.0 14.0 29.2 11.5 105.2 132.4 311.9 89.3 139.6 78.6 50.2 76.6 81.1 109.5 57.9 67.6 71.7 354.0 78.0 130.9 36.7 100.1 175.2 6.1 6.0 5.9 8.0 5.5 6.8 8.2 6.3 7.0 7.8 7.8 7.2 8.9 9.6 6.3 0.0 6.4 2.0 6.1 7.5 11.4 0.4 2.7 3.2 2.3 12.8 9.8 5.5 0.0 6.8 11.0 12.8 7.9 11.3 0.1 3.7 4.5 7.8 2.4 8.2 0.2 8.5 9.6 5.7 10.2 5.7 12.6 8.1 9.7 8.7 9.6 1.7 0.1 7.3 0.0 11.9 2.2 1.3 4.4 9.6 1.8 1.9 20.7 2.6 22.6 1.0 0.1 9.7 4.7 7.2 4.0 4.3 10.0 4.9 7.9 0.0 13.1 4.7 5.3 0.3 0.8 4.7 1.7 9.0 10.5 4.5 6.0 3.8 TRIM22 "GPSTAF50, RNF94, STAF50" ENSG00000132274 "Tripartite motif containing 22" Q8IYM9 11 5689697-5737089 "Enzymes, Predicted intracellular proteins" "Antiviral defense, Host-virus interaction, Transcription, Transcription regulation, Ubl conjugation pathway" "Repressor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "B-cells: 135.9;dendritic cells: 113.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "ASC TERT1: 174.6;BJ hTERT+ SV40 Large T+ RasG12V: 209.9;HSkMC: 190.6;TIME: 153.6" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA003307, HPA003575" Approved Supported "Nucleoplasm,Nuclear bodies,Golgi apparatus" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 16: Immune cells - Immune response" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 57: B-cells - Immune response" "Nucleoplasm, Nuclear bodies" "Golgi apparatus" "HPA003307: AB_1080381, HPA003575: AB_1080378" "unprognostic (1.47e-2)" "unprognostic (5.27e-3)" "unprognostic (4.00e-2)" "unprognostic (4.21e-3)" "unprognostic (2.21e-1)" "unprognostic (1.21e-2)" "unprognostic (1.24e-1)" "unprognostic (1.23e-1)" "unprognostic (1.19e-1)" "unprognostic (1.86e-3)" "unprognostic (2.93e-2)" "unprognostic (2.10e-1)" "unprognostic (1.98e-2)" "unprognostic (1.30e-1)" "unprognostic (2.50e-2)" "unprognostic (1.15e-1)" "unprognostic (9.16e-2)" 54.0 21.3 13.1 101.3 18.8 90.3 50.7 16.3 23.7 42.7 25.5 36.0 25.2 50.6 70.2 37.1 49.3 78.6 22.6 14.7 16.5 21.2 72.5 83.4 139.0 17.9 16.7 60.3 17.2 8.0 12.6 21.5 16.7 43.3 53.4 11.0 65.4 52.6 13.4 18.1 53.4 52.1 17.7 143.1 39.5 15.4 12.8 101.2 21.7 40.6 120.7 61.6 22.6 29.3 2.8 1.2 13.9 2.4 88.6 174.6 5.0 53.3 93.9 89.8 209.9 1.7 8.6 111.9 13.0 80.2 20.6 10.5 34.0 56.4 10.7 2.0 0.0 6.4 5.6 1.4 107.8 18.2 11.4 190.6 54.3 18.7 9.6 124.5 128.7 1.0 2.3 4.7 111.6 1.5 54.1 16.9 40.3 0.5 4.9 62.6 3.4 2.3 51.1 14.9 1.4 2.7 4.5 4.5 2.1 56.8 4.5 17.9 153.6 56.4 29.8 2.5 2.4 4.9 4.4 11.2 67.7 28.9 7.2 108.7 118.5 79.6 109.0 143.3 145.9 149.4 118.4 117.2 138.7 158.2 106.5 102.7 103.1 61.3 181.1 177.0 197.9 181.9 13.1 18.8 16.3 23.7 14.7 16.5 17.9 16.7 16.7 17.7 12.8 29.3 54.4 67.3 57.7 2.0 135.9 12.6 17.0 42.5 56.3 0.5 17.7 14.0 6.0 7.2 60.5 29.5 0.0 1.5 113.9 4.7 5.9 11.2 0.3 16.1 27.0 40.5 4.2 16.8 4.9 8.0 4.7 36.2 20.9 23.8 17.7 5.4 33.5 4.3 18.7 1.7 0.3 9.0 30.5 87.1 46.6 2.0 36.1 67.8 5.4 52.5 59.0 6.4 83.4 1.0 0.5 5.4 6.3 30.1 18.8 9.9 4.4 3.3 52.5 1.0 13.1 35.1 24.4 0.6 0.3 14.1 8.7 2.3 89.3 13.0 5.0 18.8 TRIM23 "ARD1, ARFD1, RNF46" ENSG00000113595 "Tripartite motif containing 23" P36406 5 65589690-65625975 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Host-virus interaction, Immunity, Innate immunity, Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039605 Approved NA NA "Cluster 34: Basophils - Unknown function" "Cluster 21: Non-specific - Transcription" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 59: Non-specific - Transcription" "HPA039605: AB_10673146" "unprognostic (4.06e-1)" "unprognostic (1.07e-1)" "unprognostic (5.11e-2)" "unprognostic (3.63e-1)" "unprognostic (7.96e-2)" "unprognostic (1.59e-1)" "unprognostic (1.02e-1)" "unprognostic (5.00e-3)" "unprognostic (6.51e-2)" "unprognostic (1.89e-2)" "unprognostic (1.73e-2)" "unprognostic (3.19e-1)" "unprognostic (3.19e-2)" "unprognostic (1.06e-2)" "unprognostic (2.62e-1)" "unprognostic (6.55e-3)" "unprognostic (2.70e-1)" 8.1 10.8 12.3 6.0 13.8 7.7 8.2 18.1 17.7 9.1 5.2 6.1 3.9 9.2 6.0 7.4 7.0 5.3 11.0 14.5 12.0 8.8 10.8 5.7 7.5 10.8 10.2 13.2 5.4 8.4 4.7 7.1 12.9 11.4 4.3 14.6 5.5 7.6 13.2 6.2 4.6 7.8 12.7 7.6 4.4 10.4 12.0 8.6 10.6 17.5 6.7 6.3 5.2 19.3 8.5 11.8 12.6 18.2 17.9 17.9 9.1 16.7 15.2 13.3 16.4 12.2 8.2 6.7 18.8 11.0 13.8 7.3 11.7 9.4 20.1 6.7 15.0 5.8 15.7 6.6 16.8 3.8 7.2 14.0 8.1 14.9 13.5 12.7 6.4 8.0 6.4 9.2 16.5 7.8 7.4 4.0 6.6 1.5 4.7 6.6 21.9 9.7 7.3 8.6 7.5 10.2 15.9 4.4 13.2 10.3 10.3 4.6 11.0 10.5 11.4 13.2 12.3 11.3 12.2 8.8 12.1 6.6 10.4 19.9 3.5 8.9 4.7 2.8 5.9 3.9 5.1 4.0 3.2 4.7 8.0 6.1 9.2 5.1 4.4 3.5 6.4 3.9 12.3 13.8 18.1 17.7 14.5 12.0 10.8 10.2 12.9 12.7 12.0 19.3 13.8 19.2 7.8 28.1 13.1 6.9 2.3 4.4 7.4 28.2 7.0 7.1 22.3 10.0 6.8 5.5 16.7 3.8 12.5 4.7 5.9 4.9 7.0 9.4 21.3 11.1 6.6 21.0 49.1 3.1 2.6 17.1 5.6 7.6 3.8 19.7 13.9 13.0 3.9 45.4 49.3 4.4 2.0 10.0 3.5 4.2 20.8 7.4 10.6 24.4 6.8 27.2 8.2 39.7 49.7 5.8 4.3 17.0 11.4 9.1 6.0 10.1 11.8 24.8 32.9 16.0 12.9 27.2 16.9 5.0 6.3 7.0 13.1 16.0 3.8 6.9 TRIM24 "hTIF1, RNF82, TIF1, Tif1a" ENSG00000122779 "Tripartite motif containing 24" O15164 7 138460259-138589996 "Cancer-related genes, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" "DNA-binding, Repressor, Transferase" "Cancer-related genes, Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in all" "AF22: 146.5;HMC-1: 196.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA043495, HPA061717" Approved Enhanced Nucleoplasm "Intracellular and membrane" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 23: Testis - Cell cycle regulation" "Cluster 3: HMC-1 - Innate immune response" "Cluster 40: Granulosa cells - Unknown function" Nucleoplasm "HPA043495: AB_10962915, HPA061717: AB_2684592" "unprognostic (2.40e-1)" "unprognostic (9.52e-3)" "unprognostic (2.23e-1)" "unprognostic (3.96e-2)" "unprognostic (1.20e-1)" "unprognostic (1.15e-1)" "prognostic unfavorable (9.94e-4)" "prognostic favorable (6.57e-4)" "unprognostic (4.01e-2)" "unprognostic (8.93e-2)" "unprognostic (2.53e-1)" "unprognostic (2.02e-1)" "unprognostic (4.62e-2)" "unprognostic (1.62e-1)" "unprognostic (2.25e-2)" "unprognostic (5.54e-2)" "unprognostic (6.34e-2)" 7.5 25.7 6.0 6.9 6.8 10.6 9.1 5.8 7.0 6.4 5.2 8.1 10.0 8.8 8.4 9.0 5.7 5.3 10.4 6.0 7.1 8.0 23.1 11.4 8.0 6.8 6.4 30.0 10.8 14.2 3.8 12.3 6.3 11.7 9.2 12.2 8.3 5.2 13.9 8.6 9.7 7.6 6.2 7.2 11.6 27.3 8.2 17.3 9.1 16.4 7.8 7.5 6.1 9.0 15.0 18.1 146.5 42.7 9.6 8.9 11.4 13.7 14.4 10.5 10.2 28.7 13.6 28.7 13.2 13.2 21.5 7.9 71.9 11.4 15.4 22.1 17.7 63.1 13.1 88.9 13.1 49.8 196.8 7.9 11.8 8.8 13.9 7.3 25.0 15.4 72.6 17.1 12.7 29.2 85.2 44.8 56.3 77.6 16.0 66.5 17.3 24.2 23.6 43.9 30.3 68.8 25.5 22.6 7.5 50.6 15.5 32.3 10.7 12.1 9.9 21.4 19.1 15.6 18.2 47.8 20.1 32.1 18.0 0.3 0.6 1.0 0.5 0.6 0.1 0.2 0.4 0.3 0.5 0.3 0.4 0.5 0.9 0.6 0.3 0.3 0.7 0.2 6.0 6.8 5.8 7.0 6.0 7.1 6.8 6.4 6.3 6.2 8.2 9.0 29.0 51.3 46.9 26.1 9.5 13.9 13.4 13.8 10.8 13.6 14.7 14.4 39.7 20.0 18.8 7.3 16.7 28.4 14.9 12.2 5.9 7.1 70.4 16.7 22.9 18.9 10.1 31.3 27.9 12.4 15.2 16.0 20.4 25.2 40.4 85.2 14.3 31.9 10.3 40.4 46.6 10.9 14.2 9.5 14.9 38.7 14.0 13.8 14.2 21.5 12.2 23.3 9.2 64.3 67.1 9.5 9.5 16.1 13.7 12.2 6.8 10.6 14.5 22.4 13.1 21.5 17.6 72.8 14.7 22.2 11.8 22.2 15.8 34.6 19.4 12.8 TRIM25 "EFP, RNF147, ZNF147" ENSG00000121060 "Tripartite motif containing 25" Q14258 17 56836387-56914080 "Cancer-related genes, Enzymes, Plasma proteins, Predicted intracellular proteins" "Antiviral defense, Host-virus interaction, Immunity, Innate immunity, Ubl conjugation pathway" "Ligase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 5 "neutrophil: 23.5" "Lineage enriched" "Detected in all" 7 "granulocytes: 23.5" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" HPA005909 Approved Approved "Nucleoplasm,Nuclear bodies,Cytosol" NA NA "Cluster 50: Neutrophils - Cellular senescence" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 44: Endometrium - Transcription" "Nucleoplasm, Cytosol" "Nuclear bodies" "HPA005909: AB_1078722" "unprognostic (8.73e-3)" "unprognostic (1.57e-2)" "unprognostic (2.06e-2)" "unprognostic (6.06e-2)" "unprognostic (2.69e-1)" "unprognostic (3.78e-2)" "prognostic unfavorable (9.37e-4)" "unprognostic (1.53e-1)" "unprognostic (4.23e-1)" "unprognostic (1.15e-1)" "prognostic favorable (3.36e-4)" "unprognostic (3.23e-1)" "unprognostic (3.11e-2)" "prognostic favorable (9.35e-4)" "unprognostic (5.21e-2)" "unprognostic (5.13e-2)" "unprognostic (7.39e-2)" 16.3 20.7 9.8 19.8 10.4 47.7 13.1 9.5 23.2 14.5 11.1 19.7 19.4 12.1 8.5 20.4 18.2 9.7 11.1 9.0 11.3 11.9 29.8 25.0 17.3 10.3 9.9 14.3 16.7 13.0 10.3 9.5 10.3 9.3 17.3 11.8 15.3 7.4 12.6 29.2 20.2 12.4 11.4 41.6 17.0 9.1 12.1 18.5 10.8 7.6 19.7 12.1 14.6 9.0 77.2 37.4 9.0 30.7 66.6 55.8 0.1 29.6 59.6 69.4 59.3 36.7 41.1 74.6 59.8 28.6 75.4 44.5 44.5 39.9 38.5 64.1 35.0 48.1 29.0 41.0 57.0 58.2 33.2 25.1 65.7 36.2 76.4 32.9 46.7 50.2 12.0 43.8 35.8 51.3 65.6 41.9 5.8 63.3 71.5 46.3 30.2 47.4 40.5 59.7 17.5 16.3 23.3 37.1 69.7 5.8 50.3 46.8 31.3 32.2 23.1 50.1 31.2 24.7 51.1 12.1 31.2 39.4 13.0 4.8 3.0 1.2 1.0 2.5 1.3 2.2 0.9 1.0 3.1 1.7 0.7 1.0 23.5 1.1 1.8 2.2 2.0 1.1 9.8 10.4 9.5 23.2 9.0 11.3 10.3 9.9 10.3 11.4 12.1 9.0 27.3 35.3 19.8 7.5 12.7 18.5 8.5 10.5 13.1 9.9 12.6 11.9 7.5 20.0 16.6 9.2 29.2 5.4 15.1 54.8 0.0 19.1 3.5 44.9 20.0 32.7 18.6 11.1 4.1 21.6 10.7 16.0 32.6 72.5 3.8 23.0 32.2 30.9 14.8 3.3 8.2 28.7 6.1 27.5 24.6 2.1 9.6 29.3 14.2 8.4 28.3 5.7 11.3 12.1 0.3 32.2 54.2 9.4 17.7 21.6 20.0 8.0 18.5 22.2 6.6 13.1 9.2 0.4 0.3 24.5 30.5 15.9 11.5 45.3 25.7 25.4 TRIM26 "RNF95, ZNF173" ENSG00000234127 "Tripartite motif containing 26" Q12899 6 30184455-30213427 "Enzymes, Predicted intracellular proteins" "Immunity, Innate immunity" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "Daudi: 38.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA044975, HPA050456" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 18: Non-specific - Mitochondria" "Cluster 16: U-266 - Nucleosome" "Cluster 44: Endometrium - Transcription" "Nucleoplasm, Cytosol" "HPA044975: AB_2679162, HPA050456: AB_2681133" "unprognostic (1.93e-1)" "unprognostic (5.41e-2)" "unprognostic (8.53e-2)" "unprognostic (1.96e-3)" "unprognostic (1.52e-1)" "unprognostic (5.50e-2)" "unprognostic (2.02e-1)" "unprognostic (1.40e-2)" "unprognostic (2.85e-1)" "unprognostic (3.08e-2)" "unprognostic (1.97e-1)" "unprognostic (7.00e-3)" "unprognostic (1.37e-2)" "unprognostic (1.63e-3)" "unprognostic (5.21e-2)" "unprognostic (8.82e-2)" "prognostic favorable (3.25e-5)" 15.6 16.5 3.6 6.9 4.4 4.5 16.3 4.5 7.1 15.8 3.7 17.9 5.6 16.8 2.9 28.9 16.4 4.9 12.5 3.3 4.9 18.1 26.1 16.8 6.6 4.7 4.0 12.5 15.5 4.2 14.1 2.9 4.3 18.2 2.3 4.2 21.0 3.2 14.5 20.8 19.8 1.1 3.6 18.0 17.6 11.5 4.8 3.9 17.6 1.3 6.6 17.8 17.4 4.9 15.7 8.3 0.0 23.8 8.1 4.6 7.8 9.7 5.4 11.4 11.6 0.0 0.9 38.2 13.0 12.4 17.0 17.6 0.0 16.8 3.5 0.0 13.0 6.1 2.5 16.7 7.1 13.3 5.4 4.6 5.7 11.9 7.1 0.0 7.6 18.4 2.8 0.0 0.0 0.0 19.1 17.8 0.0 0.0 6.7 16.9 15.1 5.3 9.8 14.5 0.5 11.0 18.5 0.9 5.2 5.0 8.0 2.3 16.5 8.7 5.8 0.0 0.2 15.1 31.2 18.1 0.0 21.3 15.0 0.5 1.5 0.1 1.8 1.9 1.2 1.0 1.2 1.5 1.2 1.4 0.7 1.0 0.5 0.7 1.6 0.5 1.6 1.3 3.6 4.4 4.5 7.1 3.3 4.9 4.7 4.0 4.3 3.6 4.8 4.9 13.5 28.9 21.7 18.3 23.8 30.1 22.4 13.1 34.7 20.1 22.0 18.0 13.5 18.6 15.7 12.9 16.7 18.6 31.1 21.8 11.7 16.1 0.5 25.7 15.1 16.2 22.3 1.7 16.5 15.9 14.4 12.7 17.9 34.7 5.1 12.2 9.3 52.9 13.8 13.5 25.1 15.4 6.1 17.3 25.7 1.6 7.5 21.0 17.8 18.7 24.0 12.1 21.6 18.1 26.9 13.6 15.7 12.0 26.3 20.2 17.1 15.8 24.4 19.7 6.6 10.7 12.1 5.0 13.4 42.0 34.0 17.6 28.7 9.4 17.2 22.3 TRIM27 "RFP, RNF76" ENSG00000204713 "Tripartite motif containing 27" P14373 6 28903002-28923988 "Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins" "Transcription, Transcription regulation, Transport, Ubl conjugation pathway" "DNA-binding, Repressor, Transferase" "Cancer-related genes, Proto-oncogene" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "RPMI-8226: 49.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA048684, HPA053408" Approved Approved Nucleoplasm,Nucleoli NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 18: Non-specific - Mitochondria" "Cluster 25: RPMI-8226 - Immune response" "Cluster 39: Non-specific - Basic cellular processes" Nucleoli Nucleoplasm "HPA048684: AB_2680493, HPA053408: AB_2682139" "unprognostic (1.57e-1)" "unprognostic (1.48e-2)" "unprognostic (2.36e-1)" "unprognostic (1.14e-2)" "unprognostic (1.70e-2)" "unprognostic (2.56e-1)" "unprognostic (2.00e-3)" "unprognostic (1.17e-2)" "unprognostic (1.01e-2)" "unprognostic (1.12e-3)" "unprognostic (4.76e-3)" "unprognostic (1.16e-2)" "prognostic unfavorable (3.50e-6)" "unprognostic (1.27e-1)" "unprognostic (1.41e-1)" "unprognostic (1.47e-1)" "prognostic favorable (2.71e-4)" 23.8 28.1 1.8 7.2 1.7 1.1 23.3 1.1 2.6 33.0 2.2 23.0 8.7 24.5 0.0 20.5 31.0 0.5 24.3 1.6 1.3 32.7 59.5 26.8 2.2 2.2 2.1 30.8 53.0 0.6 33.8 4.5 1.8 35.1 0.6 0.1 25.8 6.5 21.2 17.6 26.8 2.3 1.5 45.8 27.3 14.4 2.0 0.9 26.3 0.0 1.0 28.7 22.6 2.0 2.4 8.2 1.2 21.7 2.8 6.2 0.3 16.1 0.8 5.1 6.2 6.1 1.7 1.6 1.1 4.8 1.3 17.5 4.0 9.2 0.5 1.3 2.6 20.3 2.5 9.3 4.3 2.0 5.7 0.1 1.0 4.1 1.3 0.6 4.5 5.8 2.1 12.1 1.3 4.9 11.1 0.9 0.0 3.4 13.5 20.1 4.6 49.7 3.9 2.3 4.9 18.7 19.9 11.6 4.1 0.6 11.6 12.2 13.1 6.3 9.3 14.7 5.1 31.7 2.7 17.9 6.8 24.8 20.0 5.2 4.4 2.5 7.0 12.5 11.3 7.0 10.6 5.5 8.5 1.8 4.1 7.6 2.7 6.4 7.0 5.6 5.2 9.9 1.8 1.7 1.1 2.6 1.6 1.3 2.2 2.1 1.8 1.5 2.0 2.0 21.4 16.0 24.8 11.8 32.2 28.4 41.9 27.4 33.6 11.7 32.2 24.6 18.3 24.3 24.0 29.5 16.7 46.4 25.4 15.9 21.5 39.5 12.9 27.1 27.0 32.0 27.6 24.6 13.5 43.4 55.5 25.5 26.5 27.2 21.5 36.9 27.8 42.1 41.1 8.4 13.4 38.5 26.4 28.3 23.5 6.8 23.9 29.0 8.8 16.9 46.5 10.4 29.9 19.1 19.7 48.9 18.7 18.4 51.2 53.3 19.3 27.6 23.9 13.6 19.7 14.8 31.0 8.0 16.1 25.8 19.6 45.6 28.9 43.7 28.3 30.9 TRIM28 "KAP1, PPP1R157, RNF96, TF1B, TIF1B" ENSG00000130726 "Tripartite motif containing 28" Q13263 19 58544064-58550722 "Enzymes, Plasma proteins, Predicted intracellular proteins" "Host-virus interaction, Transcription, Transcription regulation, Ubl conjugation pathway" "Chromatin regulator, Repressor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HEK 293: 2817.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB010066, HPA064033" Supported Enhanced Nucleoplasm "Intracellular and membrane" NA NA 140000 "Cluster 15: NK-cells - Transcription" "Cluster 71: Testis - DNA repair" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "CAB010066: AB_2209905, HPA064033: AB_2685179" "unprognostic (2.76e-1)" "unprognostic (1.40e-1)" "unprognostic (1.16e-1)" "unprognostic (1.19e-1)" "unprognostic (1.34e-1)" "unprognostic (2.99e-1)" "prognostic unfavorable (1.85e-6)" "unprognostic (1.20e-2)" "unprognostic (2.10e-2)" "unprognostic (2.66e-1)" "unprognostic (4.92e-3)" "unprognostic (9.28e-2)" "unprognostic (2.47e-2)" "unprognostic (4.67e-2)" "unprognostic (7.34e-2)" "unprognostic (4.22e-1)" "unprognostic (3.28e-2)" 103.1 111.0 83.5 103.8 85.9 217.5 104.4 91.1 100.1 152.9 77.5 159.9 90.8 163.3 42.8 132.6 142.8 73.6 114.7 83.1 80.1 122.1 104.6 103.5 142.5 85.5 83.4 228.1 183.7 89.4 98.7 108.9 89.1 128.8 57.8 39.4 108.4 108.8 172.4 143.3 117.7 94.6 86.0 137.4 136.7 215.5 82.8 186.6 117.9 77.0 109.2 147.7 115.1 97.2 481.6 1080.4 491.9 365.1 218.9 186.5 616.5 321.5 291.1 311.4 237.0 732.8 375.0 562.5 196.1 270.7 492.8 317.7 590.5 480.5 163.6 281.3 2817.1 1012.8 407.6 537.7 254.4 640.9 577.5 252.4 248.2 385.9 274.9 220.1 301.3 597.7 507.1 259.4 284.8 705.0 756.5 640.8 372.8 443.6 637.5 761.9 340.9 550.2 260.8 730.6 517.1 403.4 343.9 359.3 170.7 131.9 273.2 493.1 272.4 643.1 273.2 148.6 562.5 397.7 665.7 604.7 293.0 432.9 418.6 1.9 9.7 8.2 12.8 11.1 17.2 15.9 18.0 17.4 13.7 19.1 22.8 20.5 4.3 24.9 7.9 21.2 12.4 10.1 83.5 85.9 91.1 100.1 83.1 80.1 85.5 83.4 89.1 86.0 82.8 97.2 60.8 12.8 18.6 18.3 51.0 64.2 60.2 34.7 47.3 61.8 86.6 87.5 9.5 51.5 29.0 33.1 27.1 61.2 72.4 88.3 23.5 44.8 96.9 70.7 53.3 49.7 64.6 46.7 10.3 56.3 61.6 48.3 65.7 80.2 21.6 136.3 35.7 31.9 46.9 55.5 12.6 79.4 14.2 36.5 70.7 110.6 65.9 48.3 28.4 6.5 32.8 49.8 19.6 10.6 18.2 56.3 50.0 41.3 43.5 52.1 47.3 36.3 28.7 34.1 59.2 69.3 61.6 158.7 83.1 58.0 60.7 56.1 54.5 80.9 94.1 45.6 TRIM31 "C6orf13, HCG1, HCGI, RNF" ENSG00000204616 "Tripartite motif containing 31" Q9BZY9 6 30102897-30113090 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "intestine: 22.1;stomach 1: 6.0;urinary bladder: 8.6" "Group enriched" "Detected in some" 4 "Distal enterocytes: 409.1;Paneth cells: 404.9;Proximal enterocytes: 193.3;Urothelial cells: 227.9" "Group enriched" "Detected in many" 5 "cervical cancer: 6.7;colorectal cancer: 25.8;pancreatic cancer: 11.4;stomach cancer: 19.8;urothelial cancer: 12.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 726 "RT4: 294.7" "Not detected" "Not detected" "Not detected" "Not detected" HPA074175 Enhanced NA NA "Cluster 37: Intestine - Unknown function" "Cluster 15: RT4 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA074175: " "unprognostic (1.37e-1)" "unprognostic (7.78e-3)" "unprognostic (1.83e-1)" "unprognostic (7.05e-3)" "unprognostic (1.75e-1)" "unprognostic (9.37e-2)" "unprognostic (6.13e-2)" "unprognostic (1.32e-1)" "unprognostic (2.05e-1)" "unprognostic (1.11e-2)" "unprognostic (1.97e-2)" "unprognostic (1.92e-1)" "unprognostic (1.43e-3)" "unprognostic (5.84e-3)" "unprognostic (6.20e-2)" "unprognostic (1.60e-1)" "unprognostic (2.50e-3)" 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.1 0.0 22.1 0.9 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 1.2 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 2.0 0.2 0.0 0.0 0.0 0.0 0.4 12.1 0.1 0.0 0.0 6.0 3.3 0.0 0.0 0.0 0.0 0.0 8.6 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 294.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.1 0.0 0.6 0.1 12.3 2.5 0.0 0.0 0.4 0.3 5.7 4.3 3.0 0.0 0.0 0.0 0.2 409.1 0.0 2.7 0.2 25.7 0.2 0.4 5.4 2.7 0.0 1.7 0.0 0.3 73.9 1.1 4.5 0.0 0.0 0.0 0.1 0.0 0.0 52.3 0.0 0.0 0.0 0.5 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.1 404.9 0.0 0.2 2.7 193.3 0.6 14.2 0.0 0.0 0.2 0.5 1.8 0.2 0.0 0.0 0.0 0.8 0.0 25.6 227.9 TRIM32 "BBS11, HT2A, LGMD2H, TATIP" ENSG00000119401 "Tripartite motif containing 32" Q13049 9 116687305-116701300 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Bardet-Biedl syndrome, Ciliopathy, Disease variant, Limb-girdle muscular dystrophy, Mental retardation, Obesity" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA050060 Approved Approved "Intermediate filaments" No No "Cluster 35: T-regs - Unknown function" "Cluster 52: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 52: Non-specific - Transcription" "Intermediate filaments" "HPA050060: AB_2681000" "unprognostic (2.47e-2)" "unprognostic (7.06e-3)" "unprognostic (5.50e-2)" "unprognostic (3.63e-1)" "unprognostic (5.08e-2)" "prognostic unfavorable (4.53e-4)" "prognostic unfavorable (4.72e-4)" "unprognostic (2.41e-3)" "unprognostic (2.92e-1)" "unprognostic (5.01e-2)" "unprognostic (1.79e-2)" "unprognostic (5.63e-2)" "unprognostic (6.03e-2)" "unprognostic (7.06e-2)" "unprognostic (2.73e-1)" "unprognostic (6.64e-3)" "unprognostic (9.77e-2)" 6.7 7.2 4.6 5.4 4.5 1.0 6.8 16.4 5.4 10.1 15.2 6.0 5.9 10.6 6.5 7.4 13.1 6.4 7.9 4.7 6.1 5.2 3.8 5.5 8.1 3.6 2.8 10.1 6.2 8.6 3.5 6.1 3.9 6.9 6.2 7.2 5.2 7.3 18.6 4.6 7.2 10.7 2.1 6.2 5.4 5.2 4.5 7.5 6.3 12.5 7.4 7.6 5.7 3.4 10.9 24.5 14.3 15.7 28.3 20.1 10.8 19.9 21.7 22.1 18.4 16.4 11.7 11.3 8.6 30.7 16.5 22.8 17.5 22.4 20.0 9.9 8.5 6.1 15.4 10.2 14.7 4.1 19.1 17.4 19.7 21.0 12.3 24.4 14.6 12.4 8.6 9.3 26.3 13.9 11.0 0.1 13.0 26.2 14.6 12.7 38.2 7.4 9.0 25.1 14.2 7.2 15.7 10.8 11.4 14.3 29.8 4.0 18.2 20.4 16.2 15.3 15.2 15.1 4.3 17.7 17.0 2.7 20.5 0.0 1.7 0.0 10.9 3.3 8.4 7.3 9.5 8.7 2.3 5.1 9.6 9.8 0.3 7.0 3.0 4.3 20.9 6.0 4.6 4.5 16.4 5.4 4.7 6.1 3.6 2.8 3.9 2.1 4.5 3.4 2.5 6.4 0.6 5.5 4.3 4.2 6.3 9.3 5.7 11.7 3.1 3.7 7.6 7.2 7.3 9.2 0.0 6.7 2.1 1.7 1.9 8.5 3.5 7.1 10.7 3.6 4.2 0.4 7.6 8.0 3.6 6.1 3.6 2.3 2.5 4.5 2.9 4.1 7.2 1.7 10.1 4.0 8.2 2.4 4.7 2.1 5.3 2.2 1.8 1.9 0.8 4.0 3.1 6.6 5.1 5.0 2.6 12.0 3.1 2.8 10.6 3.1 10.8 4.8 0.0 6.0 6.6 17.7 13.1 5.6 3.7 7.4 4.7 5.0 5.3 4.8 TRIM33 "FLJ11429, KIAA1113, PTC7, RFG7, TF1G, TIF1G, TIF1GAMMA, TIFGAMMA" ENSG00000197323 "Tripartite motif containing 33" Q9UPN9 1 114392790-114511203 "Cancer-related genes, Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" "DNA-binding, Repressor, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 237.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 13.2" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "MCF7: 115.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA004345 Supported Approved Nucleoplasm,Vesicles NA NA "Cluster 38: Basophils - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 44: Endometrium - Transcription" Vesicles Nucleoplasm "HPA004345: AB_1858287" "unprognostic (8.90e-2)" "unprognostic (5.86e-2)" "prognostic favorable (6.20e-4)" "unprognostic (1.09e-2)" "unprognostic (8.42e-3)" "prognostic favorable (8.93e-4)" "unprognostic (1.34e-2)" "unprognostic (1.83e-1)" "unprognostic (6.75e-2)" "unprognostic (4.58e-2)" "unprognostic (2.14e-1)" "unprognostic (1.08e-1)" "unprognostic (2.27e-2)" "unprognostic (4.84e-2)" "unprognostic (1.99e-1)" "unprognostic (1.40e-1)" "unprognostic (1.68e-1)" 9.3 8.1 10.1 10.7 11.3 25.4 13.5 18.3 16.9 12.5 8.2 9.5 8.8 15.2 29.8 11.7 9.1 10.9 8.9 11.5 9.9 13.5 12.2 10.9 13.3 8.0 9.1 14.4 12.2 15.3 7.3 16.0 8.2 12.6 10.1 18.8 10.7 11.0 8.8 14.8 8.9 11.8 8.1 12.7 11.2 25.3 9.5 17.8 14.2 10.7 12.8 11.5 9.8 11.3 30.9 16.3 30.1 22.6 12.5 13.1 51.0 15.4 16.3 20.9 22.1 18.5 12.8 32.8 15.5 18.1 13.6 17.4 27.6 18.0 28.6 24.9 16.4 31.6 21.7 21.6 13.8 40.3 25.3 12.5 12.9 24.9 25.2 16.0 17.8 27.3 40.1 22.5 20.2 115.4 40.9 17.0 40.7 11.7 16.3 34.8 45.9 10.8 14.9 47.7 20.8 21.9 29.2 34.7 27.4 19.3 15.8 21.7 20.1 14.5 23.4 33.8 21.7 15.7 15.6 33.4 20.4 23.0 42.0 13.2 1.2 6.1 2.5 1.5 2.2 3.0 2.6 2.7 1.5 1.4 2.0 3.1 3.6 4.1 2.4 3.0 1.6 0.8 10.1 11.3 18.3 16.9 11.5 9.9 8.0 9.1 8.2 8.1 9.5 11.3 31.0 19.2 33.3 70.5 35.4 52.8 28.9 28.6 25.6 75.6 35.9 23.9 29.2 30.0 32.3 55.2 98.0 64.9 53.9 33.3 1.9 21.0 237.3 50.4 37.5 33.2 52.1 37.9 120.7 23.6 34.0 28.7 30.1 90.0 37.4 55.6 40.7 44.3 29.6 26.9 108.5 30.4 30.5 50.3 47.9 97.9 49.0 37.2 19.6 79.6 42.9 31.5 54.6 116.6 101.8 31.4 34.9 36.9 31.6 47.3 26.6 17.3 31.4 58.3 32.9 38.3 32.5 60.0 31.9 31.2 55.4 87.7 42.8 48.1 31.2 55.3 TRIM35 "HLS5, KIAA1098, MAIR" ENSG00000104228 "Tripartite motif containing 35" Q9UPQ4 8 27284886-27311272 "Enzymes, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 40.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "ASC diff: 68.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019647 Approved Approved Nucleoplasm NA NA "Cluster 35: T-regs - Unknown function" "Cluster 27: Brain & Skin - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 51: Myeloid cells - Hemostasis" Nucleoplasm "HPA019647: AB_1858291" "unprognostic (7.67e-3)" "unprognostic (6.53e-2)" "unprognostic (1.61e-2)" "unprognostic (9.64e-3)" "unprognostic (9.35e-2)" "prognostic favorable (1.38e-4)" "unprognostic (8.79e-2)" "unprognostic (8.02e-2)" "unprognostic (5.72e-2)" "unprognostic (2.30e-1)" "unprognostic (1.12e-1)" "unprognostic (4.86e-2)" "prognostic favorable (5.59e-7)" "unprognostic (1.74e-2)" "unprognostic (1.69e-1)" "unprognostic (3.99e-2)" "unprognostic (1.92e-1)" 9.4 6.1 6.5 5.9 8.2 7.2 8.4 8.1 9.2 8.9 13.7 7.9 5.5 8.8 4.5 10.7 7.4 3.6 5.5 8.9 6.8 6.3 11.9 5.9 6.9 10.0 7.7 6.1 5.9 4.6 4.2 5.3 9.7 7.3 3.9 4.1 16.3 9.0 5.0 32.2 6.2 7.2 6.7 6.2 5.9 6.4 9.8 8.1 4.6 4.6 7.0 8.2 10.4 11.7 17.4 12.3 7.0 9.0 68.4 16.9 16.1 10.3 8.1 9.4 10.0 17.6 3.4 15.3 10.3 11.5 8.3 17.0 10.1 19.9 7.1 8.7 7.6 15.1 10.3 15.1 17.8 8.3 12.4 24.6 44.2 13.3 26.1 5.0 9.4 14.5 10.8 16.4 7.7 9.0 27.8 11.3 12.3 11.1 9.8 13.8 9.0 13.3 6.4 13.5 11.9 11.4 8.6 8.1 14.3 6.7 5.2 13.2 10.9 8.5 17.7 27.1 10.2 7.5 8.5 11.1 12.1 12.0 8.5 11.9 3.0 4.0 8.6 3.0 9.7 5.3 11.2 9.7 3.8 3.8 7.5 11.2 1.1 8.9 3.4 6.4 14.5 5.3 6.5 8.2 8.1 9.2 8.9 6.8 10.0 7.7 9.7 6.7 9.8 11.7 9.4 3.2 4.5 5.2 4.4 20.9 6.0 4.6 40.9 3.5 3.6 2.7 5.0 8.6 3.8 12.9 6.2 3.5 3.2 3.6 0.0 3.7 1.0 4.0 3.7 6.7 2.4 8.6 8.3 5.1 2.8 6.6 6.1 4.6 5.7 3.8 23.9 20.3 2.9 5.0 5.3 2.7 6.1 8.9 6.2 0.6 12.8 6.9 7.2 3.7 5.2 3.5 3.1 4.5 16.8 4.7 2.0 10.9 4.8 3.6 4.5 6.1 0.9 3.5 0.0 3.4 5.5 1.3 3.9 15.0 22.3 1.5 6.9 2.4 3.5 2.5 TRIM36 "HAPRIN, RBCC728, RNF98" ENSG00000152503 "Tripartite motif containing 36" Q9NQ86 5 115124762-115180546 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "retina: 44.2;testis: 174.3" "Group enriched" "Detected in many" 26 "Early spermatids: 2120.7;Late spermatids: 4980.3" "Cancer enhanced" "Detected in many" "prostate cancer: 9.0" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "myeloid DC: 5.8;non-classical monocyte: 6.5" "Group enriched" "Detected in many" 48 "dendritic cells: 5.8;granulocytes: 3.2;monocytes: 6.5" "Cell line enhanced" "Detected in many" "RH-30: 24.5;SCLC-21H: 28.3;SH-SY5Y: 19.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA061321 Approved Nucleoplasm,Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 77: Retina - Visual perception" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 34: Spermatids - Unknown function" "Nucleoplasm, Cytosol" "HPA061321: AB_2684479" "unprognostic (6.36e-2)" "unprognostic (2.99e-1)" "unprognostic (4.54e-2)" "unprognostic (1.32e-1)" "unprognostic (1.55e-1)" "unprognostic (2.31e-2)" "unprognostic (5.33e-6)" "unprognostic (2.19e-1)" "unprognostic (1.17e-1)" "unprognostic (1.94e-1)" "unprognostic (1.84e-1)" "unprognostic (1.90e-1)" "unprognostic (2.82e-13)" "unprognostic (4.95e-2)" "unprognostic (1.38e-1)" "unprognostic (2.19e-1)" "unprognostic (6.80e-3)" 0.5 1.3 13.2 1.6 16.7 0.5 4.4 3.9 14.2 2.4 8.7 7.5 14.1 0.9 0.6 0.3 2.2 0.5 0.2 16.1 15.7 0.3 0.4 1.8 0.3 17.0 10.5 4.7 1.6 0.2 13.4 1.1 16.1 10.0 7.5 44.2 0.5 0.6 0.2 0.6 13.8 0.8 10.2 0.5 4.6 174.3 12.7 0.7 0.2 0.4 0.4 0.4 1.3 20.0 3.6 0.9 1.6 8.4 0.2 0.1 2.0 0.7 2.8 1.5 1.7 1.2 1.7 0.0 1.4 0.1 11.9 1.1 7.9 1.5 1.1 0.6 2.7 6.0 3.3 1.7 0.3 6.0 4.8 0.1 1.4 0.7 2.0 1.9 0.1 11.2 0.2 7.9 2.3 4.6 1.6 5.4 6.7 0.6 3.8 1.3 24.5 1.9 0.9 0.1 28.3 19.6 5.3 0.5 3.2 0.8 5.8 7.4 0.7 2.3 1.8 1.7 2.7 1.2 0.8 0.0 2.5 3.4 1.1 0.0 1.2 3.2 0.0 1.3 0.0 0.0 0.0 0.0 5.8 0.1 0.0 0.0 0.3 0.0 6.5 1.2 0.0 0.6 13.2 16.7 3.9 14.2 16.1 15.7 17.0 10.5 16.1 10.2 12.7 20.0 0.4 0.0 3.4 1.0 0.1 2.3 0.6 0.2 0.6 5.0 14.8 9.3 2.3 0.0 0.5 1.8 56.3 0.0 1.8 27.6 0.0 0.4 2120.7 3.3 0.3 2.0 3.5 0.0 39.7 1.8 0.5 1.4 6.6 1.1 1.3 0.1 0.4 0.0 2.8 5.0 14.0 15.8 2.0 1.9 18.1 4980.3 14.9 6.0 8.8 29.0 3.4 6.9 0.0 2.5 53.4 1.5 20.4 12.8 0.1 12.1 28.2 0.2 5.0 76.8 6.6 2.0 2.3 136.2 26.9 1.2 1.3 0.3 0.7 0.1 8.8 0.2 TRIM37 "KIAA0898, MUL, POB1, TEF3" ENSG00000108395 "Tripartite motif containing 37" O94972 17 58982638-59106921 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Transcription, Ubl conjugation pathway" "Repressor, Transferase" "Dwarfism, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 62.3" "Cell type enhanced" "Detected in all" "Early spermatids: 129.2;Excitatory neurons: 96.7;Inhibitory neurons: 105.2;Late spermatids: 88.8;Spermatocytes: 133.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 30.4" "Group enriched" "Detected in all" 5 "granulocytes: 30.4;T-cells: 8.3" "Cell line enriched" "Detected in all" 4 "MCF7: 242.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA021911 Uncertain NA NA "Cluster 38: Basophils - Unknown function" "Cluster 21: Non-specific - Transcription" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA021911: AB_10964487" "unprognostic (4.07e-2)" "unprognostic (1.71e-1)" "unprognostic (2.99e-3)" "unprognostic (1.23e-1)" "unprognostic (2.11e-1)" "unprognostic (1.06e-1)" "prognostic unfavorable (4.99e-6)" "unprognostic (7.83e-2)" "unprognostic (1.44e-1)" "unprognostic (2.21e-1)" "unprognostic (1.10e-3)" "unprognostic (4.79e-2)" "unprognostic (2.18e-1)" "unprognostic (1.56e-1)" "unprognostic (2.46e-1)" "unprognostic (4.27e-2)" "unprognostic (3.04e-2)" 8.8 12.3 16.2 9.5 19.3 6.8 8.2 24.8 31.4 7.9 5.2 9.0 6.7 8.8 10.7 8.4 9.7 8.9 11.5 19.5 13.8 7.6 8.2 8.9 9.0 21.4 15.2 6.1 7.7 8.6 10.3 9.4 23.0 9.4 7.0 32.9 5.8 9.2 11.1 7.4 6.2 10.8 9.4 8.6 6.5 62.3 18.2 12.1 13.3 12.7 8.4 9.0 6.5 18.7 21.4 33.3 21.9 27.5 20.5 19.0 35.3 24.0 36.9 25.3 41.4 19.6 14.4 21.1 36.1 25.3 43.3 19.0 31.5 17.7 40.5 41.8 30.4 32.6 28.9 27.1 36.1 16.8 15.8 15.4 16.1 32.5 40.8 25.8 33.0 19.1 25.4 29.7 24.9 242.4 34.0 9.5 31.5 28.9 22.0 15.0 57.1 13.7 24.0 29.7 51.7 29.9 24.8 10.2 23.2 26.4 30.4 7.8 25.9 39.5 47.6 36.5 27.6 30.5 48.5 18.5 26.8 17.5 18.7 30.4 3.7 4.5 7.2 2.7 6.7 3.6 4.7 4.6 4.0 3.9 4.0 5.4 5.3 3.4 2.8 3.0 8.3 3.1 16.2 19.3 24.8 31.4 19.5 13.8 21.4 15.2 23.0 9.4 18.2 18.7 10.3 9.6 11.0 44.4 13.2 7.9 6.0 6.5 15.4 19.7 13.2 12.2 24.1 7.2 15.6 9.2 33.3 15.1 7.8 12.0 3.9 10.3 129.2 30.8 13.8 13.7 12.0 12.8 96.7 5.6 10.6 14.0 11.7 13.5 10.8 18.0 12.1 18.9 8.7 45.4 105.2 7.2 16.2 9.1 6.9 88.8 9.9 9.3 12.4 18.7 7.2 19.9 5.2 36.2 43.5 10.2 11.3 17.7 15.1 9.9 3.3 9.7 29.1 38.8 13.1 10.9 17.3 133.1 45.0 14.0 6.3 17.8 14.7 19.7 9.1 6.8 TRIM38 "RNF15, RORET" ENSG00000112343 "Tripartite motif containing 38" O00635 6 25962802-25991231 "Enzymes, Predicted intracellular proteins" "Immunity, Innate immunity, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA031685 Approved Approved "Plasma membrane,Cell Junctions,Centrosome" NA NA "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 16: Immune cells - Immune response" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 57: B-cells - Immune response" Centrosome "Plasma membrane, Cell Junctions" "HPA031685: AB_10603218" "unprognostic (6.62e-2)" "unprognostic (1.65e-3)" "unprognostic (3.34e-1)" "unprognostic (2.72e-2)" "unprognostic (1.25e-1)" "unprognostic (6.51e-2)" "unprognostic (7.79e-2)" "unprognostic (3.27e-2)" "unprognostic (2.78e-2)" "prognostic favorable (8.95e-5)" "unprognostic (2.81e-2)" "unprognostic (6.28e-2)" "unprognostic (2.73e-1)" "unprognostic (3.36e-1)" "unprognostic (4.49e-2)" "prognostic favorable (8.20e-5)" "prognostic favorable (4.94e-9)" 7.1 6.0 1.8 10.8 1.8 13.0 6.1 1.6 2.4 7.3 3.4 5.8 6.6 7.3 9.6 7.8 7.4 6.6 3.7 1.7 1.9 9.9 5.6 9.3 13.6 3.0 2.1 4.6 3.2 2.9 2.0 6.3 2.7 7.0 7.3 0.4 6.1 6.2 7.6 5.2 8.9 6.1 2.4 14.3 5.8 2.1 2.7 7.7 5.5 3.0 14.6 7.0 7.0 2.7 4.8 2.6 0.4 5.6 13.0 17.3 4.6 5.9 11.7 11.2 18.5 2.0 5.0 10.5 9.4 7.3 10.8 7.3 3.6 5.8 6.6 10.7 2.3 4.8 4.6 2.0 17.2 5.7 9.4 17.4 4.2 6.9 2.5 9.2 9.8 5.0 3.2 5.7 13.5 2.3 5.5 6.4 1.8 0.0 3.5 8.3 5.4 11.2 13.3 9.3 0.1 0.1 4.4 9.1 16.2 0.6 1.3 7.3 10.1 2.0 3.4 3.5 4.0 6.5 5.1 11.7 5.4 6.9 12.6 12.1 10.2 4.7 6.9 12.5 6.6 13.1 5.8 6.2 9.8 15.1 5.4 6.0 11.4 6.5 11.7 9.0 7.9 7.1 1.8 1.8 1.6 2.4 1.7 1.9 3.0 2.1 2.7 2.4 2.7 2.7 37.6 25.6 47.1 0.3 120.2 14.9 56.9 16.1 24.5 0.6 20.1 12.8 6.0 18.6 32.4 46.0 0.0 23.5 88.5 48.3 17.6 28.5 1.1 48.4 28.1 39.9 18.1 10.3 0.1 14.9 23.5 25.5 24.5 69.4 35.5 52.4 35.0 17.5 32.6 0.0 0.1 33.3 16.2 94.0 32.7 2.8 19.9 81.3 10.6 34.7 113.2 0.2 107.1 0.0 0.2 20.4 47.4 18.8 34.3 39.7 48.3 69.5 22.7 1.1 6.6 23.1 28.2 0.3 0.5 42.7 9.2 21.2 53.1 23.0 25.6 94.7 TRIM39 RNF23 ENSG00000204599 "Tripartite motif containing 39" Q9HCM9 6 30326479-30343729 "Enzymes, Predicted intracellular proteins" "Apoptosis, Cell cycle, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA051120, HPA059496" Uncertain Supported Cytosol NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 71: Testis - DNA repair" "Cluster 2: Karpas-707 - Immune response" "Cluster 7: Non-specific - Mitochondria" Cytosol "HPA051120: AB_2681348, HPA059496: AB_2684040" "unprognostic (2.90e-1)" "unprognostic (1.61e-2)" "unprognostic (2.79e-2)" "unprognostic (2.86e-2)" "unprognostic (6.38e-2)" "unprognostic (4.55e-2)" "unprognostic (1.46e-2)" "unprognostic (1.15e-2)" "unprognostic (3.47e-1)" "unprognostic (9.44e-2)" "prognostic favorable (2.50e-4)" "unprognostic (1.30e-2)" "unprognostic (4.69e-2)" "unprognostic (6.35e-3)" "unprognostic (1.46e-1)" "unprognostic (1.06e-1)" "unprognostic (2.39e-3)" 10.0 8.7 0.8 1.7 1.0 3.1 10.2 1.3 1.1 11.4 1.5 13.6 1.6 12.1 2.2 13.1 11.7 1.3 8.7 0.9 0.9 9.8 11.6 9.7 1.6 1.3 1.0 11.5 12.2 2.1 14.8 1.6 1.0 10.8 1.5 1.5 10.2 2.0 14.3 9.3 11.9 1.8 0.8 14.3 11.0 20.7 1.1 1.7 11.6 1.4 2.1 12.9 9.5 1.1 3.2 0.1 2.6 4.8 1.2 1.2 2.7 1.4 1.8 2.1 1.9 3.8 0.4 4.1 2.8 2.7 1.3 1.0 3.1 2.2 2.2 3.2 3.4 3.2 0.5 1.4 2.7 4.8 3.5 1.4 1.8 2.7 2.9 3.2 1.3 3.4 4.9 3.2 2.7 2.9 1.0 1.0 3.6 1.3 2.2 2.2 0.5 3.1 2.2 3.0 5.7 2.8 1.1 2.3 2.8 2.5 3.1 1.2 1.2 2.3 1.8 2.8 4.9 5.7 7.6 4.2 1.3 1.7 3.6 1.0 0.9 4.1 2.7 1.3 2.4 1.8 1.9 2.0 0.9 1.6 2.2 2.2 4.5 2.6 1.4 0.7 1.7 1.4 0.8 1.0 1.3 1.1 0.9 0.9 1.3 1.0 1.0 0.8 1.1 1.1 5.9 3.2 7.2 0.7 14.2 3.7 5.6 2.6 6.8 6.0 7.5 5.2 5.6 2.8 3.5 1.8 6.2 4.7 11.9 5.5 7.9 4.6 4.6 11.2 4.1 4.8 5.4 3.6 0.9 6.1 5.7 4.1 15.3 13.1 5.7 4.2 5.7 3.7 3.3 3.3 1.1 7.3 4.1 7.2 5.0 7.8 2.8 7.3 3.6 1.0 4.3 6.9 8.2 0.5 0.9 6.8 10.0 4.5 10.9 3.7 7.5 4.0 7.2 7.6 0.0 3.8 5.8 19.1 10.0 5.3 4.1 10.0 15.3 3.5 4.4 5.3 TRIM4 RNF87 ENSG00000146833 "Tripartite motif containing 4" Q9C037 7 99876958-99919531 "Enzymes, Predicted intracellular proteins" "Immunity, Innate immunity, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "HPA019356, HPA029461" Approved Supported "Plasma membrane,Cytosol" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 89: Fibroblasts - ECM organization" "Cluster 30: Epithelial cell lines - Translation" "Cluster 63: NK-cells & T-cells - Immune response" Cytosol "Plasma membrane" "HPA019356: AB_1856376, HPA029461: AB_10600834" "unprognostic (1.88e-1)" "unprognostic (2.97e-2)" "unprognostic (3.37e-1)" "unprognostic (3.46e-2)" "unprognostic (1.80e-2)" "unprognostic (7.06e-2)" "unprognostic (1.22e-1)" "unprognostic (5.42e-2)" "unprognostic (3.85e-2)" "unprognostic (2.67e-3)" "unprognostic (2.48e-2)" "unprognostic (1.60e-1)" "prognostic favorable (7.36e-6)" "unprognostic (1.00e-1)" "unprognostic (2.38e-1)" "unprognostic (7.46e-2)" "unprognostic (5.65e-2)" 18.7 21.5 11.0 17.1 11.5 9.3 26.8 15.5 12.6 18.9 15.4 17.3 17.5 23.7 19.8 15.3 22.9 15.2 10.0 10.5 11.9 20.6 22.9 18.5 22.4 11.2 11.9 41.3 23.8 25.5 16.2 19.9 10.9 23.0 19.2 21.5 19.0 20.2 7.5 21.8 18.6 19.9 10.7 21.5 20.1 16.0 12.0 20.9 24.5 11.8 23.8 17.3 17.3 13.3 20.8 26.2 14.4 12.0 37.0 34.6 6.3 34.6 41.3 28.0 32.4 13.1 20.1 30.3 0.1 28.8 24.2 24.3 19.0 21.2 28.4 31.2 1.4 25.3 13.1 20.8 52.4 35.9 29.4 36.9 44.3 21.6 54.7 37.8 24.6 14.9 37.1 45.3 23.9 26.4 26.8 32.2 10.9 31.0 21.0 15.0 20.6 34.6 31.6 26.4 16.8 11.9 26.4 39.4 42.3 20.7 18.2 20.2 30.6 30.7 27.6 59.5 33.6 37.7 44.4 24.0 20.1 39.7 41.7 38.2 28.4 23.6 28.5 28.6 32.8 26.2 29.4 32.6 24.9 25.3 40.7 30.4 11.7 22.3 26.1 18.5 32.8 28.0 11.0 11.5 15.5 12.6 10.5 11.9 11.2 11.9 10.9 10.7 12.0 13.3 17.8 25.6 20.1 19.2 32.3 25.1 24.8 17.7 25.0 21.6 21.8 18.0 6.1 18.6 14.2 22.0 18.8 16.4 28.1 10.1 9.8 15.9 7.4 12.5 25.4 18.8 9.0 16.8 18.3 12.8 6.7 20.1 19.4 11.4 27.3 19.0 22.5 20.4 14.3 6.7 20.7 10.4 16.2 21.4 14.8 13.1 31.1 21.2 23.2 12.2 27.0 35.9 32.0 23.1 22.5 14.9 10.4 27.4 20.1 26.6 17.8 19.0 16.5 22.1 0.0 21.8 20.4 22.4 9.4 18.0 23.0 16.3 29.8 52.5 13.5 23.6 TRIM40 RNF35 ENSG00000204614 "Tripartite motif containing 40" Q6P9F5 6 30136124-30148735 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 8 "intestine: 3.0;liver: 1.6;testis: 1.4" "Group enriched" "Detected in some" 5 "Distal enterocytes: 20.1;Paneth cells: 24.7" "Cancer enhanced" "Detected in some" "colorectal cancer: 0.7;stomach cancer: 0.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 12 "HEL: 1.1" "Region enriched" "Detected in single" 18 "thalamus: 3.1" "Low region specificity" "Detected in many" HPA043818 Uncertain Approved Cytosol NA NA "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 36: HEL - Hemostasis" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "HPA043818: AB_10963090" "unprognostic (2.88e-1)" "unprognostic (5.20e-2)" "unprognostic (4.11e-1)" "unprognostic (1.13e-1)" "unprognostic (1.77e-1)" "unprognostic (4.84e-2)" 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 1.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.0 0.0 0.0 0.0 0.1 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 20.1 0.0 0.0 0.2 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.7 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 24.7 0.0 0.0 0.0 3.8 0.5 0.0 0.0 0.0 0.0 0.0 3.1 0.0 0.0 0.0 0.3 0.0 0.0 0.7 0.0 TRIM41 "MGC1127, RINCK" ENSG00000146063 "Tripartite motif containing 41" Q8WV44 5 181222499-181235808 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 57.8" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "HDLM-2: 77.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA024204 Approved Supported "Nucleoli,Nuclear bodies" NA NA "Cluster 35: T-regs - Unknown function" "Cluster 70: Brain - Nervous system development" "Cluster 44: HDLM-2 - Immune response" "Cluster 52: Non-specific - Transcription" "Nucleoli, Nuclear bodies" "HPA024204: AB_1858299" "unprognostic (1.13e-1)" "unprognostic (7.05e-2)" "unprognostic (1.23e-2)" "unprognostic (7.93e-2)" "unprognostic (1.61e-1)" "unprognostic (1.07e-1)" "unprognostic (9.56e-2)" "unprognostic (7.24e-2)" "unprognostic (8.66e-2)" "unprognostic (6.87e-2)" "unprognostic (2.21e-3)" "unprognostic (2.07e-1)" "unprognostic (5.17e-3)" "unprognostic (2.45e-3)" "unprognostic (1.34e-1)" "prognostic unfavorable (4.22e-4)" "unprognostic (2.68e-2)" 7.9 9.6 52.7 7.5 57.8 8.1 5.8 48.3 50.8 6.9 31.3 6.6 8.4 7.6 5.8 10.1 6.4 3.2 9.4 42.2 44.1 9.5 12.2 6.2 4.9 57.3 57.3 6.0 9.9 11.7 10.9 4.1 53.2 6.8 2.7 7.0 7.6 5.6 26.1 9.8 7.2 3.5 54.5 8.2 8.8 13.2 53.8 10.1 11.7 12.7 5.2 6.8 6.7 54.7 9.3 24.0 8.7 14.6 10.1 10.0 20.6 13.3 7.2 9.6 9.0 20.4 13.8 16.0 21.4 9.1 18.0 17.3 9.1 31.9 5.2 77.8 29.2 17.8 24.9 11.7 9.7 13.3 11.8 8.8 16.1 12.0 4.2 9.3 5.6 23.8 22.7 18.8 5.3 33.8 20.0 14.7 8.3 7.0 11.3 18.7 13.2 20.9 5.5 14.7 13.5 12.7 12.3 14.3 18.7 3.8 28.7 14.8 11.7 13.1 8.9 8.0 10.3 41.2 28.1 21.9 13.7 15.3 11.3 0.2 0.3 0.6 0.6 0.3 0.9 0.5 0.6 1.1 0.4 0.6 0.6 0.8 1.0 0.6 0.7 0.7 0.9 0.4 52.7 57.8 48.3 50.8 42.2 44.1 57.3 57.3 53.2 54.5 53.8 54.7 9.1 3.2 12.4 11.4 10.1 8.0 9.5 7.5 8.0 19.1 10.5 8.9 13.2 12.8 10.0 11.0 18.8 14.6 13.6 12.3 11.7 8.5 8.0 15.8 12.9 10.4 12.7 5.9 5.2 12.1 10.0 7.5 16.8 12.4 2.5 12.3 10.4 21.0 8.8 28.6 5.3 13.1 12.2 15.1 7.3 4.0 5.3 10.1 8.8 5.6 11.8 15.0 14.4 1.5 5.8 9.9 12.3 11.7 11.1 9.5 16.0 8.0 24.1 30.4 0.0 24.4 10.7 33.2 23.7 12.3 11.2 13.0 13.6 10.2 12.6 8.3 TRIM47 "GOA, RNF100" ENSG00000132481 "Tripartite motif containing 47" Q96LD4 17 75874164-75878581 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Pancreatic endocrine cells: 105.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "RPMI-8226: 48.4;RPTEC TERT1: 36.0;U-266/70: 39.2" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA014933 Uncertain Supported Cytosol NA NA "Cluster 13: T-cells - Unknown function" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 25: RPMI-8226 - Immune response" "Cluster 1: Pancreatic cells - Digestion" Cytosol "HPA014933: AB_10603219" "prognostic favorable (6.54e-4)" "unprognostic (8.42e-2)" "unprognostic (1.42e-1)" "unprognostic (2.42e-2)" "unprognostic (1.19e-2)" "unprognostic (4.07e-2)" "prognostic unfavorable (5.59e-5)" "unprognostic (2.08e-2)" "unprognostic (9.18e-3)" "unprognostic (2.74e-1)" "unprognostic (1.18e-1)" "unprognostic (1.55e-1)" "prognostic unfavorable (9.69e-5)" "unprognostic (3.94e-2)" "unprognostic (1.44e-2)" "unprognostic (3.01e-2)" "unprognostic (9.98e-2)" 20.6 10.3 43.4 6.5 45.1 0.3 17.7 39.9 68.1 20.4 38.8 31.9 9.0 29.2 3.9 19.1 17.6 7.6 26.7 41.7 42.3 39.2 17.8 18.9 4.3 50.1 46.8 7.2 18.0 5.8 8.8 2.6 43.1 16.8 4.5 0.8 24.4 4.9 6.8 19.9 19.6 6.1 41.5 28.9 17.4 7.4 53.0 1.8 12.8 4.5 4.3 31.4 21.4 45.7 20.6 14.8 0.1 0.1 3.2 3.4 0.5 0.8 1.6 1.1 0.9 2.8 10.2 0.0 12.9 0.7 10.1 23.4 3.7 5.5 0.1 13.2 9.4 0.1 10.2 28.3 5.3 0.1 0.1 2.8 1.5 2.3 2.0 1.0 10.1 1.6 2.2 30.3 0.6 3.5 2.0 0.3 1.6 7.9 29.1 1.5 1.8 48.4 36.0 0.7 5.8 0.4 6.1 29.1 8.4 0.8 3.5 0.6 15.6 18.0 11.3 1.8 7.1 39.2 12.1 2.5 7.8 0.0 1.7 0.0 0.0 1.4 1.7 0.0 4.6 2.4 4.0 2.2 0.1 2.1 2.6 1.7 0.0 2.2 0.0 1.2 5.4 0.6 43.4 45.1 39.9 68.1 41.7 42.3 50.1 46.8 43.1 41.5 53.0 45.7 34.3 16.0 5.4 26.4 5.2 18.0 39.8 34.8 34.1 6.0 20.8 23.4 4.8 40.0 13.8 16.5 0.0 0.5 2.6 30.2 19.6 67.5 0.5 13.6 17.7 39.6 8.4 1.3 1.9 76.6 1.4 33.7 22.4 12.6 22.2 17.1 43.5 11.4 63.5 0.0 1.4 12.5 57.0 9.1 14.5 1.0 34.2 8.2 42.7 8.4 2.6 10.3 0.0 5.5 5.8 105.2 4.7 19.2 12.5 57.0 42.0 66.3 16.7 0.9 32.9 14.5 36.4 1.0 2.2 22.1 15.9 0.8 7.9 2.0 11.8 19.2 TRIM5 "RNF88, TRIM5alpha" ENSG00000132256 "Tripartite motif containing 5" Q9C035 11 5663195-5938619 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Antiviral defense, Autophagy, Host-virus interaction, Immunity, Innate immunity, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "CAB013497, HPA023420, HPA023422" Approved Supported Cytosol NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 29: Non-specific - Vesicular transport" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Cytosol "CAB013497: , HPA023420: AB_1856378, HPA023422: AB_1856379" "unprognostic (2.60e-1)" "unprognostic (9.62e-2)" "unprognostic (2.04e-2)" "unprognostic (1.41e-2)" "unprognostic (6.88e-2)" "unprognostic (4.74e-3)" "unprognostic (5.48e-3)" "unprognostic (5.82e-2)" "unprognostic (1.49e-1)" "unprognostic (6.76e-3)" "unprognostic (8.54e-3)" "unprognostic (1.64e-1)" "unprognostic (2.20e-2)" "unprognostic (1.90e-1)" "unprognostic (1.09e-1)" "unprognostic (1.07e-2)" "unprognostic (6.12e-2)" 8.8 10.9 2.1 8.1 2.3 3.8 8.0 2.0 2.4 11.8 7.2 7.2 7.4 11.7 18.4 7.7 9.4 6.9 5.7 2.0 3.3 9.0 12.8 11.8 8.4 4.0 3.5 11.4 13.3 4.2 3.8 9.6 3.4 8.5 7.7 1.9 14.0 9.1 1.9 5.5 8.5 11.3 3.0 10.4 7.8 8.3 3.5 9.4 9.6 4.0 8.9 8.2 8.6 2.9 7.7 15.4 19.2 12.4 24.0 22.5 5.4 18.0 35.0 37.3 50.0 13.8 13.5 5.5 13.3 18.8 27.6 13.0 18.4 25.8 14.9 9.6 5.1 15.2 10.4 9.5 20.2 11.5 15.3 15.4 22.7 10.5 31.3 22.9 52.8 8.9 16.9 12.2 32.1 4.2 7.7 5.3 7.7 11.7 8.1 14.3 4.7 1.5 23.7 14.4 0.5 1.1 11.8 18.4 6.8 20.7 9.3 6.6 43.3 13.9 20.2 3.6 4.2 9.4 7.9 1.9 10.9 6.8 15.4 10.7 7.6 11.6 3.6 7.8 3.0 3.1 2.8 2.8 9.4 2.6 1.8 3.7 7.7 4.1 8.0 7.0 2.2 4.1 2.1 2.3 2.0 2.4 2.0 3.3 4.0 3.5 3.4 3.0 3.5 2.9 14.2 6.4 14.0 4.9 8.7 5.2 9.5 9.7 9.6 0.2 8.3 6.5 4.9 2.8 13.4 11.0 0.0 7.8 16.4 5.5 5.9 10.6 5.0 8.6 12.6 14.8 1.2 8.4 3.0 8.8 10.5 12.4 6.1 12.5 0.0 11.9 15.4 13.9 6.4 0.0 1.4 9.7 4.1 12.2 7.1 3.8 7.8 10.8 3.6 19.7 10.8 7.0 14.4 3.0 1.0 8.1 4.9 7.5 6.7 10.1 7.4 6.3 3.7 0.1 19.7 6.5 10.9 5.2 3.3 7.0 5.4 7.8 7.5 20.6 7.5 9.9 TRIM50 "FLJ32804, TRIM50A" ENSG00000146755 "Tripartite motif containing 50" Q86XT4 7 73312536-73328082 "Enzymes, Human disease related genes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "pancreas: 29.1;parathyroid gland: 33.3;stomach 1: 48.7" "Cell type enhanced" "Detected in some" "Early spermatids: 2.3;Gastric mucus-secreting cells: 17.9;Spermatocytes: 5.2;Spermatogonia: 4.2" "Group enriched" "Detected in some" 8 "liver cancer: 2.9;renal cancer: 6.0" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 32 "Hep G2: 6.8" "Not detected" "Not detected" "Low region specificity" "Detected in some" "HPA019862, HPA047843" Uncertain Approved Cytosol NA NA "Cluster 29: Non-specific - Vesicular transport" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 20: Spermatogonia & Spermatocytes - Spermatogenesis" Cytosol "HPA019862: AB_1858305, HPA047843: AB_2680176" "unprognostic (1.93e-1)" "unprognostic (3.93e-1)" "unprognostic (1.07e-2)" "unprognostic (5.96e-2)" "unprognostic (3.87e-1)" "unprognostic (2.66e-2)" "unprognostic (1.49e-1)" "unprognostic (3.04e-3)" "unprognostic (2.63e-2)" "unprognostic (2.00e-1)" "unprognostic (2.13e-1)" "unprognostic (1.33e-1)" "prognostic favorable (9.36e-7)" "unprognostic (3.91e-2)" "unprognostic (1.60e-1)" "unprognostic (1.20e-1)" "unprognostic (2.25e-1)" 0.5 0.2 0.1 0.0 0.0 0.0 0.2 0.0 0.2 0.0 0.1 0.2 1.1 0.0 0.0 0.1 0.1 0.1 0.1 0.1 0.1 6.8 0.3 0.1 0.0 0.1 0.1 0.2 29.1 33.3 0.0 0.3 0.1 0.0 0.0 0.0 0.1 0.0 1.7 0.0 0.9 0.0 0.1 0.4 48.7 8.7 0.1 0.0 0.3 0.4 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 6.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 1.1 2.3 0.0 0.0 0.0 0.0 0.0 0.1 0.9 0.1 0.0 17.9 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.1 0.0 0.0 0.0 0.0 0.9 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.1 0.8 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 5.2 4.2 0.0 0.0 0.1 0.0 0.0 0.1 0.0 TRIM52 RNF102 ENSG00000183718 "Tripartite motif containing 52" Q96A61 5 181254417-181261139 "Enzymes, Predicted intracellular proteins" "Antiviral defense, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Not detected" "Not detected" "HPA054565, HPA056819" Approved Approved "Nucleoli,Intermediate filaments" NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 77: Retina - Visual perception" "Cluster 20: HeLa - Mitochondria" "Cluster 52: Non-specific - Transcription" Nucleoli "Intermediate filaments" "HPA054565: AB_2682525, HPA056819: AB_2683245" "unprognostic (1.21e-1)" "unprognostic (1.43e-1)" "unprognostic (2.38e-2)" "unprognostic (5.23e-1)" "unprognostic (2.75e-1)" "unprognostic (1.10e-1)" "unprognostic (5.16e-2)" "unprognostic (3.98e-2)" "unprognostic (7.37e-2)" "unprognostic (2.71e-1)" "unprognostic (2.24e-3)" "unprognostic (7.48e-3)" "prognostic unfavorable (3.46e-4)" "unprognostic (2.96e-1)" "unprognostic (6.41e-2)" "unprognostic (1.33e-2)" "prognostic favorable (4.07e-4)" 9.3 10.0 10.8 8.6 10.9 8.7 9.0 14.0 14.4 14.2 11.0 12.2 8.1 10.1 9.1 7.0 12.3 5.5 11.0 10.9 10.8 13.7 11.6 12.1 14.2 11.4 10.5 16.0 15.6 9.2 18.9 5.9 11.6 15.2 6.6 21.5 11.5 7.0 6.7 10.0 13.1 5.3 9.6 18.7 11.0 11.6 11.4 10.8 17.3 3.9 9.7 12.0 10.8 11.7 4.3 4.9 7.8 10.0 13.8 8.7 6.9 4.6 4.1 4.4 3.8 7.1 7.7 9.3 4.9 5.0 12.0 7.8 4.2 6.2 5.1 16.0 8.9 3.6 21.4 6.0 3.3 11.0 7.9 8.7 5.1 4.7 2.7 7.2 5.3 13.5 3.8 21.3 4.6 8.1 6.1 10.0 2.7 4.8 6.3 7.1 4.2 6.4 3.7 5.6 8.8 7.1 6.6 4.7 4.4 6.8 8.8 7.4 6.5 8.8 4.6 4.2 4.4 15.5 8.1 6.3 10.0 9.5 3.5 5.8 2.2 5.2 7.1 1.9 7.9 4.9 7.5 7.8 1.8 3.5 9.2 7.5 2.3 5.1 1.9 2.4 5.5 3.3 10.8 10.9 14.0 14.4 10.9 10.8 11.4 10.5 11.6 9.6 11.4 11.7 11.9 19.2 23.6 6.5 20.5 8.8 6.5 3.1 8.0 27.8 6.7 6.7 9.4 8.6 15.0 7.3 39.6 3.7 28.1 7.2 3.9 3.5 27.2 10.3 14.4 14.0 9.0 8.6 9.5 2.5 1.1 12.6 6.6 11.8 17.7 21.2 7.9 3.5 4.2 28.6 10.5 8.3 2.0 6.0 9.7 5.4 12.8 10.3 5.4 9.4 12.5 17.3 35.0 6.6 8.1 2.3 8.1 9.4 24.9 4.5 8.1 3.4 11.6 42.9 0.0 20.3 13.3 25.2 11.0 5.5 6.1 4.2 25.9 19.0 7.8 4.1 TRIM56 RNF109 ENSG00000169871 "Tripartite motif containing 56" Q9BRZ2 7 101085481-101097967 "Enzymes, Predicted intracellular proteins" "Antiviral defense, Immunity, Innate immunity, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA024358 Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Cytosol" "HPA024358: AB_1858308" "unprognostic (6.47e-2)" "unprognostic (1.34e-1)" "unprognostic (1.99e-2)" "unprognostic (1.62e-1)" "unprognostic (9.44e-3)" "unprognostic (8.30e-2)" "prognostic unfavorable (3.87e-4)" "unprognostic (2.63e-1)" "unprognostic (4.11e-1)" "unprognostic (3.90e-1)" "unprognostic (1.91e-1)" "unprognostic (1.43e-1)" "unprognostic (2.35e-2)" "unprognostic (2.47e-3)" "unprognostic (8.13e-2)" "unprognostic (1.49e-1)" "prognostic favorable (2.13e-4)" 13.6 11.3 12.9 14.4 13.9 6.7 12.9 11.7 12.2 14.8 12.6 11.8 11.7 13.5 13.4 12.4 14.8 7.5 9.9 10.4 11.5 12.9 10.8 17.7 15.4 17.0 13.8 19.0 10.1 9.6 8.6 8.9 14.0 14.8 9.7 2.0 14.0 13.0 11.9 15.7 14.7 8.5 12.7 21.4 12.4 3.8 14.2 12.9 12.7 6.7 12.4 12.6 13.4 16.8 16.4 20.1 8.5 10.9 19.1 19.7 10.2 13.4 11.7 21.2 19.6 9.6 23.0 19.2 14.0 11.1 29.3 18.4 3.5 12.3 14.2 19.2 5.5 12.2 28.9 7.1 17.1 21.6 26.4 12.6 17.3 13.8 22.4 20.7 11.2 12.2 21.6 23.7 14.8 22.4 18.3 24.0 8.5 8.8 16.7 16.8 13.9 12.7 11.1 16.9 0.4 0.3 14.8 40.8 11.6 10.8 9.3 14.0 21.6 29.4 26.1 22.4 14.4 11.7 12.4 14.7 14.6 17.2 23.6 1.7 1.2 1.2 1.8 0.8 1.4 1.1 1.4 1.2 0.4 1.6 1.3 1.7 3.9 4.1 1.2 1.1 0.7 0.6 12.9 13.9 11.7 12.2 10.4 11.5 17.0 13.8 14.0 12.7 14.2 16.8 62.5 73.7 82.7 3.3 45.7 5.2 82.2 6.7 28.5 3.1 30.4 27.2 21.7 108.7 32.8 51.5 2.1 41.6 45.4 51.9 3.9 61.4 2.1 60.8 53.7 80.6 29.1 43.5 0.1 48.1 25.7 40.0 33.1 42.5 15.2 129.9 114.5 48.1 19.3 10.1 0.1 40.9 4.1 48.7 4.5 5.2 132.3 33.3 1.8 8.4 60.0 20.4 141.1 2.5 3.6 56.9 45.4 94.4 24.9 79.9 76.5 11.4 51.0 4.0 65.7 76.7 38.9 5.4 7.2 15.9 3.3 29.8 44.3 64.5 41.1 60.5 TRIM58 BIA2 ENSG00000162722 "Tripartite motif containing 58" Q8NG06 1 247857187-247880138 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "bone marrow: 32.2;thyroid gland: 15.2" "Cell type enriched" "Detected in many" 23 "Erythroid cells: 456.4" "Cancer enhanced" "Detected in many" "thyroid cancer: 2.7" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HAP1: 18.3;HEL: 40.7;K-562: 21.8;PC-3: 37.0;U-2 OS: 29.0;WM-115: 42.1" "Not detected" "Not detected" "Low region specificity" "Detected in many" HPA023637 Uncertain NA NA "Cluster 37: B-cells - Transcription" "Cluster 67: Neutrophils - Humoral immune response" "Cluster 36: HEL - Hemostasis" "Cluster 6: Erythroid cells - Oxygen transport" "HPA023637: AB_1858309" "unprognostic (3.85e-1)" "unprognostic (5.24e-3)" "unprognostic (7.00e-2)" "unprognostic (6.52e-4)" "unprognostic (1.46e-1)" "unprognostic (3.47e-2)" "unprognostic (1.10e-1)" "unprognostic (4.14e-5)" "unprognostic (3.59e-1)" "unprognostic (2.07e-1)" "unprognostic (1.27e-1)" "unprognostic (5.00e-2)" "unprognostic (3.31e-1)" "unprognostic (1.08e-2)" "unprognostic (3.34e-1)" "unprognostic (1.00e-2)" "unprognostic (2.57e-2)" 0.5 0.6 0.7 0.6 0.5 32.2 0.5 0.1 1.0 0.4 0.0 1.1 0.1 0.2 0.1 0.1 1.3 0.3 0.2 0.6 2.9 0.2 0.2 1.3 0.2 3.2 4.1 0.0 0.2 0.1 0.2 5.8 4.3 1.5 0.9 0.6 0.3 0.2 0.2 0.9 0.3 0.6 1.3 2.4 0.4 2.7 3.1 0.3 15.2 1.6 0.1 0.2 0.2 0.9 0.0 0.0 0.0 0.0 0.7 2.5 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 2.3 0.0 0.4 1.7 18.3 0.0 0.0 0.0 1.3 40.7 0.0 0.0 0.0 5.5 2.4 0.0 0.0 0.2 0.0 0.0 0.0 1.4 21.8 0.1 0.0 0.0 0.2 0.3 2.7 0.0 37.0 0.0 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.8 0.2 4.7 0.0 0.0 29.0 0.0 0.0 6.3 0.0 0.0 0.0 13.0 42.1 0.7 0.1 0.3 0.0 0.1 0.0 0.8 0.0 0.0 0.2 0.2 0.0 0.0 0.6 0.3 0.1 0.1 0.0 0.6 0.7 0.5 0.1 1.0 0.6 2.9 3.2 4.1 4.3 1.3 3.1 0.9 0.6 3.2 3.0 0.3 1.7 1.0 1.4 0.0 0.6 3.4 1.1 0.3 0.5 0.0 5.6 1.8 12.5 3.3 0.4 0.8 0.0 0.1 4.3 2.5 0.7 1.7 1.2 456.4 3.7 0.0 4.6 3.0 0.0 2.1 8.2 0.4 1.8 0.1 2.4 0.0 1.8 0.4 0.0 3.2 1.4 1.2 0.9 19.4 1.8 0.0 1.0 2.7 2.1 0.5 0.3 0.2 0.7 0.7 0.3 4.0 0.0 0.2 3.7 3.7 0.0 0.9 0.7 2.8 9.7 0.1 0.9 4.9 1.7 0.3 0.8 0.8 TRIM6 RNF89 ENSG00000121236 "Tripartite motif containing 6" Q9C030 11 5596109-5612958 "Enzymes, Predicted intracellular proteins" "Host-virus interaction, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "kidney: 20.9" "Cell type enriched" "Detected in many" 4 "Proximal tubular cells: 74.4" "Cancer enhanced" "Detected in many" "testis cancer: 7.8" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "neutrophil: 1.1" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "NTERA-2: 22.2;SuSa: 36.7;TIME: 19.2;U-2 OS: 21.3" "Not detected" "Not detected" "Not detected" "Not detected" HPA060514 Uncertain NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 7: Kidney - Transmembrane transport" "Cluster 5: NTERA-2 - Transcription" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA060514: AB_2684300" "unprognostic (9.00e-2)" "unprognostic (2.10e-3)" "unprognostic (9.16e-3)" "unprognostic (1.82e-1)" "unprognostic (3.25e-3)" "unprognostic (3.25e-3)" "unprognostic (2.35e-2)" "unprognostic (3.26e-3)" "unprognostic (8.59e-2)" "unprognostic (3.40e-2)" "unprognostic (8.61e-2)" "unprognostic (3.90e-1)" "unprognostic (5.68e-2)" "unprognostic (4.65e-4)" "unprognostic (4.77e-1)" "unprognostic (3.33e-2)" "unprognostic (4.36e-1)" 2.8 3.8 0.4 1.7 0.4 2.0 3.2 0.2 0.4 2.2 0.8 2.1 0.5 3.2 4.8 4.3 3.2 2.3 0.9 0.4 0.6 20.9 0.8 2.1 0.6 0.9 0.6 4.3 1.3 1.3 0.9 5.4 0.6 2.5 1.7 0.2 10.5 3.6 0.8 1.0 1.1 5.2 0.6 3.7 1.0 9.3 0.8 1.3 3.8 0.6 1.3 2.6 2.8 0.7 0.7 16.2 1.1 0.0 2.0 2.9 18.7 4.4 3.3 4.3 4.2 0.4 3.6 0.0 2.5 4.5 12.1 2.9 7.5 6.7 6.1 0.6 5.0 2.0 1.6 0.1 0.7 6.6 8.7 5.1 6.4 6.2 4.3 6.4 3.8 0.1 8.0 0.2 1.8 0.2 0.0 0.9 22.2 2.6 5.7 7.7 0.0 0.1 0.9 6.6 0.1 0.2 0.0 8.4 0.8 36.7 3.2 1.1 19.2 4.0 21.3 0.1 4.7 0.2 0.1 0.0 3.7 0.0 3.5 0.2 0.2 0.4 0.0 0.0 0.0 0.1 0.0 0.0 0.7 0.0 0.0 0.0 1.1 0.3 0.0 0.2 0.0 0.1 0.4 0.4 0.2 0.4 0.4 0.6 0.9 0.6 0.6 0.6 0.8 0.7 1.2 0.0 4.8 0.0 0.1 0.5 0.6 0.5 1.8 0.0 3.1 1.8 0.4 0.0 0.8 1.8 0.0 12.5 0.0 0.2 3.9 1.2 1.2 0.7 1.7 1.5 0.0 2.1 0.0 0.2 15.5 2.1 0.0 1.0 0.0 4.1 0.0 0.5 3.1 0.0 0.0 0.3 2.0 3.5 0.3 0.8 0.9 1.1 1.8 0.0 2.2 0.0 0.0 0.0 0.0 0.6 0.1 1.9 0.0 0.4 0.3 74.4 1.1 0.0 0.0 0.5 0.7 10.8 3.3 1.8 0.4 5.7 0.4 4.1 0.2 0.3 TRIM62 "DEAR1, FLJ10759" ENSG00000116525 "Tripartite motif containing 62" Q9BVG3 1 33145399-33182059 "Enzymes, Predicted intracellular proteins" "Immunity, Innate immunity, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 21.0" "Cell type enhanced" "Detected in many" "Oligodendrocyte precursor cells: 50.8;Oligodendrocytes: 26.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in all" "AF22: 23.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA050061 Approved "Vesicles,Focal adhesion sites" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 27: Brain & Skin - Unknown function" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 68: Oligodendrocytes - Mixed function" "Vesicles, Focal adhesion sites" "HPA050061: AB_2681001" "unprognostic (1.57e-1)" "unprognostic (4.39e-2)" "unprognostic (2.39e-2)" "unprognostic (2.62e-2)" "unprognostic (1.14e-2)" "unprognostic (5.80e-2)" "unprognostic (5.10e-5)" "unprognostic (2.05e-2)" "unprognostic (1.14e-1)" "unprognostic (4.32e-2)" "unprognostic (3.55e-3)" "unprognostic (3.66e-1)" "prognostic unfavorable (7.08e-5)" "unprognostic (2.14e-1)" "unprognostic (1.10e-1)" "unprognostic (1.05e-1)" "unprognostic (2.05e-3)" 3.1 6.6 8.7 2.9 13.1 4.8 3.6 10.0 11.9 3.2 2.3 3.2 2.4 3.1 2.6 5.1 3.0 2.0 3.5 8.5 10.4 3.5 1.8 3.1 4.6 10.7 11.3 3.7 3.1 2.9 6.4 3.4 12.1 5.1 2.1 2.1 5.2 2.9 4.9 12.5 4.2 2.8 7.4 5.1 4.3 2.3 12.4 5.2 3.9 2.5 4.5 4.8 4.4 21.0 3.7 2.7 23.9 3.9 5.7 2.5 7.6 3.4 9.9 6.3 5.5 3.0 3.7 5.9 3.8 3.0 3.2 7.2 5.0 4.3 5.6 5.8 3.8 6.5 3.2 2.5 5.7 2.2 16.2 5.2 3.9 8.7 2.0 9.9 6.3 5.0 1.1 3.8 6.1 9.9 6.8 2.0 6.0 4.3 3.5 8.6 12.8 2.7 3.8 9.6 6.0 3.7 3.8 14.5 16.8 12.6 4.1 1.4 6.3 2.7 3.8 8.1 2.8 6.9 3.3 2.7 5.1 3.9 3.5 1.2 1.0 3.4 1.3 1.8 2.3 1.1 1.9 1.8 0.9 1.4 1.3 1.2 2.3 1.0 1.1 0.4 4.7 1.1 8.7 13.1 10.0 11.9 8.5 10.4 10.7 11.3 12.1 7.4 12.4 21.0 2.0 3.2 2.2 2.6 1.8 2.7 0.8 1.7 2.8 3.4 3.5 1.9 0.9 0.0 1.2 1.8 0.0 1.1 2.5 1.5 0.0 1.4 0.5 0.6 1.1 1.4 1.8 0.4 1.9 1.9 1.8 2.1 4.1 1.3 1.3 1.7 1.1 0.7 1.2 10.1 10.2 1.5 4.1 1.2 1.6 0.5 2.5 1.3 0.0 10.3 1.4 1.5 3.1 50.8 26.0 2.6 0.6 4.9 2.6 2.1 1.2 1.0 0.4 1.0 6.6 2.0 2.1 1.3 0.6 2.8 4.7 1.4 3.0 3.4 0.9 2.0 TRIM63 "IRF, MURF-1, RNF28, SMRZ" ENSG00000158022 "Tripartite motif containing 63" Q969Q1 1 26051301-26068436 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" "Muscle protein, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "skeletal muscle: 1935.8" "Cell type enriched" "Detected in some" 7 "Cardiomyocytes: 272.2" "Cancer enriched" "Detected in some" 10 "melanoma: 31.0" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 40 "ASC diff: 16.1;SK-MEL-30: 55.7" "Not detected" "Not detected" "Region enhanced" "Detected in some" "cerebellum: 5.1" NA NA "Cluster 33: Striated muscle - Muscle contraction" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 54: Cardiomyocytes - Muscle contraction" "unprognostic (1.10e-1)" "unprognostic (4.80e-4)" "unprognostic (1.45e-2)" "unprognostic (7.52e-3)" "unprognostic (1.44e-1)" "unprognostic (2.05e-2)" "unprognostic (3.42e-1)" "unprognostic (1.12e-1)" "unprognostic (2.71e-1)" "unprognostic (1.06e-1)" "unprognostic (3.17e-1)" "unprognostic (1.01e-1)" "unprognostic (2.16e-2)" "unprognostic (5.90e-2)" "unprognostic (1.33e-2)" "unprognostic (2.32e-1)" "unprognostic (5.58e-2)" 1.2 0.2 0.0 0.0 0.1 0.0 0.8 0.0 0.1 1.5 0.0 0.7 0.3 8.8 0.3 7.1 0.6 2.7 243.0 0.0 0.0 1.5 0.4 1.3 0.0 0.1 0.1 0.2 0.8 0.0 0.2 4.0 0.0 1.5 0.2 0.1 9.6 0.4 1935.8 4.2 0.8 3.5 0.0 0.2 0.8 0.2 0.2 0.3 0.5 387.6 0.2 8.9 1.1 0.1 0.0 0.0 0.0 0.0 16.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.9 0.0 0.1 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 55.7 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.2 0.1 0.0 0.0 0.6 0.0 0.0 0.9 0.1 0.0 0.0 0.0 0.4 0.0 272.2 5.7 0.0 1.8 0.0 0.5 0.0 0.0 1.9 1.8 0.0 0.0 0.0 2.0 0.0 0.0 0.1 0.0 0.1 8.1 0.0 0.1 10.1 0.0 0.0 0.0 0.6 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.5 12.4 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.3 0.0 3.3 29.7 0.0 0.0 0.0 34.7 1.4 0.0 0.0 0.0 0.1 1.6 6.1 0.0 0.1 0.1 TRIM68 "FLJ10369, RNF137, SS-56" ENSG00000167333 "Tripartite motif containing 68" Q6AZZ1 11 4598672-4608231 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA023455 Uncertain Supported Nucleoplasm,Cytosol NA NA "Cluster 44: Non-specific - Transcription" "Cluster 89: Fibroblasts - ECM organization" "Cluster 44: HDLM-2 - Immune response" "Cluster 43: Cardiomyocytes - Nuclear processes" "Nucleoplasm, Cytosol" "HPA023455: AB_1858319" "unprognostic (4.77e-2)" "unprognostic (5.15e-2)" "unprognostic (1.18e-1)" "unprognostic (4.10e-2)" "unprognostic (4.13e-2)" "unprognostic (8.63e-2)" "unprognostic (2.01e-2)" "unprognostic (1.28e-1)" "unprognostic (2.01e-1)" "unprognostic (6.70e-2)" "unprognostic (2.75e-2)" "unprognostic (7.78e-2)" "prognostic favorable (4.14e-6)" "unprognostic (4.23e-2)" "unprognostic (2.98e-1)" "unprognostic (1.61e-1)" "unprognostic (1.37e-1)" 5.1 6.5 6.6 3.7 7.0 2.1 6.4 7.2 7.2 9.6 6.3 7.1 6.6 6.5 7.2 5.0 7.6 5.1 7.2 6.6 7.0 9.7 7.4 6.6 5.2 6.6 6.9 10.1 6.2 8.9 6.3 6.2 6.8 10.7 6.2 5.8 8.3 8.1 5.9 4.8 6.0 6.0 6.8 6.8 8.0 6.5 7.3 6.5 9.6 6.6 5.8 7.0 5.3 7.2 10.2 11.2 4.5 8.2 7.2 11.6 0.0 10.9 8.0 9.9 8.9 1.4 10.3 6.9 6.5 5.6 9.3 11.6 4.5 7.7 8.4 17.2 8.8 8.4 2.9 0.0 8.3 13.7 11.4 9.1 11.1 5.7 8.6 10.2 12.6 6.3 8.0 3.7 8.9 2.4 11.3 3.7 5.4 7.1 9.2 9.0 6.4 0.3 6.3 4.4 2.4 4.3 0.0 11.0 7.1 9.0 4.8 6.8 10.3 13.1 8.8 13.3 5.0 13.7 15.9 9.9 8.9 6.0 12.5 8.6 2.5 8.9 7.9 4.8 8.8 8.5 8.8 8.9 5.6 7.6 11.1 9.0 0.3 5.7 5.5 3.8 8.7 7.4 6.6 7.0 7.2 7.2 6.6 7.0 6.6 6.9 6.8 6.8 7.3 7.2 3.2 0.0 3.6 2.9 2.8 0.8 1.4 2.7 3.4 3.3 2.6 2.4 5.4 2.8 5.9 5.5 2.1 6.1 2.7 5.3 5.9 3.2 0.9 2.6 2.2 3.4 6.7 1.3 1.7 3.3 2.7 2.9 4.6 2.8 3.8 5.9 3.6 6.0 2.2 0.0 1.6 5.2 6.1 2.1 0.6 0.4 1.8 2.0 0.0 1.9 2.7 4.1 5.2 3.5 3.0 3.3 1.9 1.9 1.8 2.0 2.4 2.5 2.4 2.8 6.6 2.0 2.6 2.9 6.6 2.0 1.0 4.4 2.8 3.9 4.7 0.6 TRIM69 "RNF36, Trif, TRIMLESS" ENSG00000185880 "Tripartite motif containing 69" Q86WT6 15 44728988-44767829 "Enzymes, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 5 "testis: 35.0" "Cell type enhanced" "Detected in all" "Early spermatids: 213.2;Late spermatids: 93.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in single" 5 "T-reg: 4.2" "Lineage enriched" "Detected in single" 7 "T-cells: 4.2" "Cell line enhanced" "Detected in some" "Karpas-707: 2.4;U-266/70: 8.2;U-266/84: 2.3" "Not detected" "Not detected" "Not detected" "Not detected" HPA028894 Enhanced NA NA "Cluster 4: T-regs - Cell cycle regulation" "Cluster 78: Testis - Spermatogenesis" "Cluster 29: U-266 - Adaptive immune response" "Cluster 66: Spermatocytes - Spermatogenesis" "HPA028894: AB_10603136" "unprognostic (4.82e-3)" "unprognostic (1.23e-2)" "unprognostic (4.10e-1)" "unprognostic (2.01e-1)" "unprognostic (1.75e-2)" "unprognostic (4.20e-1)" "unprognostic (9.27e-2)" "unprognostic (4.95e-2)" "unprognostic (6.49e-2)" "unprognostic (3.53e-3)" "unprognostic (1.38e-1)" "unprognostic (3.72e-2)" "prognostic favorable (2.26e-5)" "unprognostic (4.79e-2)" "unprognostic (1.82e-1)" "unprognostic (1.91e-2)" "unprognostic (1.49e-2)" 0.8 0.8 5.2 0.4 5.2 0.2 0.8 4.7 7.1 0.9 4.5 1.2 0.4 0.6 0.4 0.7 0.8 0.5 2.8 5.0 5.1 1.6 1.5 1.3 0.9 5.2 5.0 0.8 0.4 0.3 1.5 0.2 5.1 0.8 0.5 0.6 0.8 0.2 5.9 1.0 1.3 0.6 5.0 2.4 0.7 35.0 5.0 0.5 0.6 6.0 1.2 0.7 0.8 5.4 0.1 0.1 0.2 0.6 0.2 0.7 0.0 0.1 0.3 0.8 1.3 0.0 0.3 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.4 1.7 0.0 0.2 0.1 0.0 0.7 0.0 0.1 0.9 0.6 0.1 0.1 1.1 0.2 0.7 0.0 2.4 0.2 0.0 0.0 0.1 0.1 0.4 0.0 0.1 0.0 0.0 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.4 0.2 8.2 2.3 1.4 0.2 0.2 0.1 0.0 0.0 0.0 0.2 0.1 0.6 0.6 0.8 0.9 0.0 0.0 0.2 0.6 0.1 0.0 0.2 0.0 4.2 0.1 5.2 5.2 4.7 7.1 5.0 5.1 5.2 5.0 5.1 5.0 5.0 5.4 41.8 6.4 5.1 9.4 22.1 21.3 21.3 8.0 12.0 10.8 9.3 9.1 60.2 8.6 11.0 9.2 4.2 6.1 20.4 16.5 41.1 42.1 213.2 9.0 12.2 22.2 4.2 5.7 16.0 16.0 4.2 17.8 13.7 10.6 14.0 10.5 11.4 5.1 36.3 23.5 9.8 7.5 8.2 25.4 39.7 93.9 9.3 22.6 12.4 1.0 52.7 21.2 20.6 9.5 1.7 14.8 13.4 11.7 21.9 11.4 18.6 27.0 8.8 4.2 6.6 27.0 19.7 78.8 1.7 25.0 41.2 1.5 25.6 5.1 7.0 52.5 TRIM7 "GNIP, RNF90" ENSG00000146054 "Tripartite motif containing 7" Q9C029 5 181193924-181205293 "Cancer-related genes, Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 4 "skeletal muscle: 193.3;tongue: 51.0" "Cell type enhanced" "Detected in many" "Basal keratinocytes: 17.8;Cardiomyocytes: 40.1;Squamous epithelial cells: 39.6;Suprabasal keratinocytes: 28.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in single" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "HaCaT: 16.4;HDLM-2: 35.0;PC-3: 18.8;TIME: 16.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" HPA039213 Approved Approved Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 35: T-regs - Unknown function" "Cluster 33: Striated muscle - Muscle contraction" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 37: Myocytes - Muscle contraction" Vesicles "Nucleoplasm, Cytosol" "HPA039213: AB_10795173" "unprognostic (6.58e-2)" "unprognostic (1.17e-1)" "unprognostic (5.20e-2)" "unprognostic (1.10e-2)" "unprognostic (6.85e-2)" "unprognostic (1.80e-2)" "unprognostic (3.89e-4)" "unprognostic (3.45e-2)" "unprognostic (3.72e-1)" "unprognostic (1.64e-1)" "unprognostic (3.48e-2)" "unprognostic (1.97e-1)" "unprognostic (7.16e-3)" "unprognostic (1.26e-1)" "unprognostic (3.90e-2)" "unprognostic (6.17e-2)" "unprognostic (1.15e-2)" 2.1 1.5 1.2 0.4 1.0 0.4 2.1 10.5 3.0 5.5 0.4 1.9 0.3 1.3 3.1 27.0 2.2 0.2 8.5 0.9 1.7 3.9 0.6 2.6 0.4 3.1 2.9 1.5 4.8 2.7 5.5 0.3 2.8 2.8 0.5 1.6 7.3 0.6 193.3 28.7 1.3 0.6 1.3 1.4 2.2 1.3 2.0 0.4 6.3 51.0 2.1 2.2 9.5 1.3 9.0 4.4 0.1 0.5 0.7 0.8 0.2 1.9 0.0 0.7 1.8 0.4 12.0 0.6 6.1 2.6 3.7 16.4 4.8 13.8 0.2 35.0 1.8 0.9 12.2 0.2 2.2 0.0 2.0 0.1 10.5 0.4 6.7 2.7 3.9 1.6 0.5 2.0 0.4 1.3 0.5 0.3 0.0 14.5 18.8 0.4 6.0 1.4 4.9 0.0 0.4 1.1 4.2 0.2 6.5 0.2 1.0 0.4 16.0 0.2 3.4 0.6 6.3 2.8 0.4 1.0 0.5 0.7 1.5 0.0 1.7 0.0 0.4 0.7 0.7 0.1 0.4 0.4 0.3 0.2 0.7 0.5 0.0 0.1 0.5 0.2 0.9 0.3 1.2 1.0 10.5 3.0 0.9 1.7 3.1 2.9 2.8 1.3 2.0 1.3 7.3 0.0 1.1 0.0 1.0 17.8 4.3 11.1 12.0 6.2 0.8 1.5 40.1 0.0 6.3 3.7 0.0 0.1 0.8 5.9 5.9 0.7 0.9 0.2 0.3 4.6 0.0 0.0 1.3 2.4 0.7 4.8 11.2 0.7 0.0 0.1 5.7 0.4 1.1 0.0 3.9 3.3 2.0 6.0 2.8 0.0 0.9 2.9 1.8 0.0 5.7 0.6 1.0 2.0 0.1 5.0 6.5 1.5 0.1 2.5 0.0 1.5 2.9 2.9 13.1 17.3 5.8 1.5 0.4 39.6 28.4 0.0 1.4 0.1 3.4 5.3 TRIM71 "LIN-41, LIN41" ENSG00000206557 "Tripartite motif containing 71" Q2Q1W2 3 32817997-32897824 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "RNA-mediated gene silencing, Ubl conjugation pathway" "Developmental protein, RNA-binding, Transferase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 5 "testis: 4.8" "Cell type enhanced" "Detected in some" "Alveolar cells type 1: 9.6;Extravillous trophoblasts: 15.6;Inhibitory neurons: 4.5;Oligodendrocyte precursor cells: 4.5;Spermatogonia: 13.7" "Cancer enriched" "Detected in some" 28 "testis cancer: 28.6" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 31.4;BEWO: 94.5;Hep G2: 63.8;NTERA-2: 84.3;SuSa: 76.3" "Not detected" "Not detected" "Low region specificity" "Detected in single" "HPA038141, HPA038142" Uncertain Approved "Plasma membrane,Actin filaments,Focal adhesion sites" NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 5: NTERA-2 - Transcription" "Cluster 38: Extravillous trophoblasts - Unknown function" "Plasma membrane, Actin filaments, Focal adhesion sites" "HPA038141: AB_2675857, HPA038142: AB_10697240" "unprognostic (2.93e-2)" "unprognostic (4.29e-3)" "unprognostic (1.70e-1)" "unprognostic (1.02e-2)" "unprognostic (2.58e-2)" "unprognostic (3.27e-2)" "unprognostic (2.09e-2)" "unprognostic (1.25e-1)" "unprognostic (3.16e-2)" "unprognostic (3.04e-1)" "unprognostic (1.11e-2)" "unprognostic (3.11e-1)" "unprognostic (4.36e-6)" "unprognostic (3.92e-2)" "unprognostic (9.27e-2)" "unprognostic (8.17e-2)" "unprognostic (4.65e-2)" 0.0 0.0 1.0 0.0 1.0 0.2 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.9 0.8 0.9 0.0 0.7 0.0 0.1 0.1 0.0 0.0 0.0 0.2 0.2 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.8 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 31.4 0.0 0.0 0.0 94.5 0.0 0.0 0.0 0.0 23.1 0.0 0.0 0.0 0.0 0.0 0.0 8.4 0.0 0.0 0.0 0.0 1.6 0.0 63.8 0.0 1.8 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.3 1.3 0.4 0.0 0.0 0.6 6.9 84.3 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 76.3 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 3.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 1.0 0.0 0.8 0.9 0.8 0.1 0.1 0.1 0.0 0.8 0.2 0.0 9.6 4.1 0.0 0.0 0.0 0.0 0.0 0.0 3.2 0.1 0.0 2.7 0.0 1.8 0.0 0.0 3.9 0.0 0.0 0.0 0.0 1.0 0.2 0.0 0.2 0.0 0.0 3.1 0.0 15.6 0.3 0.0 0.1 0.0 0.0 0.0 0.0 1.1 0.0 4.5 0.0 0.0 0.0 0.0 0.5 0.3 0.0 0.0 1.0 0.1 0.0 0.0 4.5 0.1 0.0 0.0 0.4 0.0 0.0 0.0 3.6 0.7 0.5 0.0 0.0 0.1 0.3 13.7 0.0 0.0 4.0 0.1 0.0 0.0 0.0 TRIM8 "GERP, RNF27" ENSG00000171206 "Tripartite motif containing 8" Q9BZR9 10 102644479-102658318 "Enzymes, Predicted intracellular proteins" "Immunity, Innate immunity, Ubl conjugation pathway" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA023560, HPA023561" Approved Supported Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 38: Basophils - Unknown function" "Cluster 35: Non-specific - Unknown function" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "Vesicles, Cytosol" "HPA023560: AB_10600414, HPA023561: AB_10601861" "unprognostic (4.32e-2)" "unprognostic (6.90e-2)" "unprognostic (3.02e-3)" "unprognostic (1.45e-1)" "unprognostic (1.78e-1)" "unprognostic (5.03e-1)" "unprognostic (3.82e-2)" "unprognostic (1.03e-1)" "unprognostic (2.15e-3)" "unprognostic (4.62e-2)" "unprognostic (5.41e-2)" "unprognostic (1.52e-1)" "unprognostic (9.55e-2)" "unprognostic (1.48e-1)" "unprognostic (3.12e-2)" "unprognostic (8.34e-2)" "unprognostic (1.36e-2)" 80.1 47.6 67.2 21.5 68.1 26.0 58.4 62.9 55.0 63.0 35.8 50.9 17.8 53.5 9.3 42.0 55.6 22.0 67.8 55.0 56.5 77.9 62.2 70.3 18.3 72.4 72.7 45.2 80.4 36.6 43.5 21.3 64.7 55.5 9.5 18.1 69.1 21.9 80.8 48.3 43.8 17.1 60.4 42.8 61.9 20.1 84.4 18.7 67.4 38.8 11.8 62.9 49.9 54.2 96.4 18.7 16.3 28.7 17.2 40.6 21.1 34.4 59.3 32.1 24.6 30.7 93.0 30.7 102.9 57.5 11.4 32.7 12.2 40.4 21.3 34.4 23.4 78.3 12.9 67.4 55.8 15.5 28.3 47.0 21.9 64.8 32.9 83.4 40.6 13.6 17.3 33.4 24.3 45.5 27.8 57.7 12.7 25.6 38.0 18.6 49.2 16.6 37.4 48.0 12.3 26.2 18.8 17.2 42.6 16.9 58.4 28.2 94.8 40.9 22.4 23.3 68.8 49.0 28.5 16.3 65.5 39.2 9.7 14.0 5.2 2.7 6.8 4.6 6.5 8.9 7.3 5.4 4.5 7.4 6.4 5.7 17.9 6.0 5.7 12.4 7.5 4.5 67.2 68.1 62.9 55.0 55.0 56.5 72.4 72.7 64.7 60.4 84.4 54.2 46.0 57.7 71.2 33.6 29.5 31.5 12.6 21.2 21.6 33.4 53.9 45.3 38.0 38.6 33.6 88.3 8.4 13.0 52.8 15.4 41.1 63.2 1.1 91.5 61.7 30.1 21.6 2.5 8.9 44.9 2.6 38.9 20.4 81.6 8.8 32.2 31.8 33.3 25.4 28.6 13.6 32.8 18.3 40.5 24.1 1.7 31.1 43.5 17.8 13.1 58.1 26.1 24.7 18.1 17.6 65.0 16.4 34.3 18.6 30.5 32.0 53.0 38.5 15.1 13.1 35.7 38.4 2.4 5.1 19.8 22.9 10.9 26.6 38.9 21.4 30.1 TRIM9 "RNF91, SPRING" ENSG00000100505 "Tripartite motif containing 9" Q9C026 14 50975262-51096061 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 63.3;retina: 20.9" "Cell type enhanced" "Detected in some" "Astrocytes: 324.2;Excitatory neurons: 545.6;Inhibitory neurons: 381.1;Oligodendrocyte precursor cells: 582.1;Oligodendrocytes: 143.7" "Cancer enriched" "Detected in some" 8 "glioma: 25.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "AN3-CA: 32.2;HAP1: 23.0;HDLM-2: 36.5;SCLC-21H: 32.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 6: Brain - Smell perception" "Cluster 44: HDLM-2 - Immune response" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "unprognostic (1.22e-1)" "unprognostic (6.37e-2)" "unprognostic (1.17e-1)" "unprognostic (1.10e-3)" "unprognostic (6.67e-2)" "unprognostic (1.13e-2)" "unprognostic (2.24e-3)" "unprognostic (7.66e-2)" "unprognostic (1.88e-1)" "unprognostic (3.06e-2)" "unprognostic (2.38e-3)" "unprognostic (1.06e-1)" "unprognostic (1.20e-1)" "unprognostic (1.55e-1)" "unprognostic (9.00e-2)" "unprognostic (7.57e-6)" "unprognostic (1.85e-3)" 0.9 2.1 31.1 1.2 39.6 0.9 1.2 63.3 45.5 3.7 0.0 6.3 0.2 4.6 1.3 0.4 0.8 4.4 1.2 45.6 14.1 1.0 2.3 0.5 0.2 12.4 18.9 1.3 0.6 0.1 13.5 0.3 12.3 0.8 0.9 20.9 2.1 3.1 0.6 0.9 1.2 3.2 12.4 0.3 1.0 1.0 28.0 0.9 0.5 0.4 0.2 0.7 1.8 32.3 0.0 3.7 5.7 32.2 0.0 0.0 2.1 0.0 0.0 0.4 0.9 2.5 0.3 0.4 0.2 0.5 5.5 0.1 23.0 0.0 0.9 36.5 4.6 1.8 0.1 0.0 0.0 1.3 1.2 0.9 0.0 0.6 0.0 0.1 0.0 3.1 0.0 0.2 0.9 0.1 7.2 0.9 1.9 0.1 4.9 4.2 8.3 0.2 0.1 0.0 32.7 2.6 0.5 0.1 7.3 0.3 0.5 0.9 0.0 2.1 0.9 0.0 1.5 0.6 0.1 0.4 9.6 0.9 12.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 31.1 39.6 63.3 45.5 45.6 14.1 12.4 18.9 12.3 12.4 28.0 32.3 0.1 0.0 0.0 324.2 0.2 0.5 0.1 0.2 0.6 51.5 0.6 4.3 1.4 1.5 0.0 0.0 33.3 0.4 0.0 2.2 1.9 0.3 0.2 0.3 0.3 0.4 1.2 0.0 545.6 0.0 2.9 1.6 0.0 0.7 0.0 0.8 0.7 0.1 0.2 1.7 381.1 0.0 2.0 0.3 0.3 0.2 2.1 0.0 7.2 28.1 0.0 44.4 0.0 582.1 143.7 0.1 0.1 4.1 1.1 0.2 0.0 0.3 0.0 25.9 0.0 14.8 0.4 0.4 0.8 0.2 0.0 0.3 0.4 0.1 0.2 0.0 TRIML1 "FLJ36180, RNF209" ENSG00000184108 "Tripartite motif family like 1" Q8N9V2 4 188139441-188147743 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Developmental protein, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in single" 121 "testis: 12.0" "Cell type enriched" "Detected in some" 4 "Early spermatids: 138.2" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 5 "BEWO: 1.4" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 36: Testis - Spermatogenesis" "Cluster 28: BEWO - Transcription regulation" "Cluster 29: Early spermatids - Spermatogenesis" "unprognostic (6.99e-2)" "unprognostic (5.21e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 138.2 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 29.7 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.4 0.0 0.0 1.1 0.0 0.0 0.0 0.0 TRIML2 "FLJ25801, SPRYD6" ENSG00000179046 "Tripartite motif family like 2" Q8N7C3 4 188091273-188109603 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "placenta: 4.1;testis: 2.6" "Group enriched" "Detected in some" 6 "Cytotrophoblasts: 16.5;Early spermatids: 17.3;Extravillous trophoblasts: 6.7;Late spermatids: 5.2;Spermatocytes: 6.4;Spermatogonia: 6.4;Syncytiotrophoblasts: 8.9" "Cancer enriched" "Detected in some" 33 "testis cancer: 24.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 4 "SuSa: 145.3" "Not detected" "Not detected" "Not detected" "Not detected" HPA043838 Uncertain Approved "Plasma membrane,Cytosol" NA NA "Cluster 28: Placenta - Pregnancy" "Cluster 12: NES - Nervous system development" "Cluster 47: Cytotrophoblasts - Unknown function" "Plasma membrane, Cytosol" "HPA043838: AB_10963835" "unprognostic (3.32e-1)" "unprognostic (1.99e-1)" "unprognostic (1.30e-1)" "unprognostic (9.82e-2)" "unprognostic (1.21e-5)" "unprognostic (3.06e-2)" "unprognostic (1.65e-3)" "unprognostic (2.65e-1)" "unprognostic (0.00e+0)" "unprognostic (2.26e-2)" "unprognostic (1.20e-1)" "unprognostic (1.28e-3)" 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 3.7 33.8 0.0 0.0 0.0 0.1 18.3 0.2 1.4 0.0 0.0 0.2 0.5 0.0 0.0 0.0 7.5 0.9 6.4 0.1 0.0 2.4 0.0 0.0 1.6 0.0 0.0 0.0 0.0 0.0 21.4 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 34.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.1 0.0 145.3 0.0 0.0 0.2 0.1 7.6 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.3 0.0 0.0 0.0 0.0 0.0 0.3 0.3 0.0 0.0 0.0 0.0 16.5 0.0 0.0 0.0 0.0 17.3 0.0 0.0 0.1 0.0 0.0 1.6 0.0 6.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.3 0.0 0.0 0.0 0.5 5.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 6.4 6.4 0.0 0.0 8.9 0.1 0.0 0.0 0.3 TRIO ARHGEF23 ENSG00000038382 "Trio Rho guanine nucleotide exchange factor" O75962 5 14143342-14532128 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Guanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase" "Cancer-related genes, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in many" 4 "Astrocytes: 205.7;Excitatory neurons: 400.9;Inhibitory neurons: 443.4;Microglial cells: 308.2;Oligodendrocyte precursor cells: 476.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "U-87 MG: 215.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA008157, HPA064664" Supported Approved Vesicles,Cytosol No No "Cluster 15: NK-cells - Transcription" "Cluster 35: Non-specific - Unknown function" "Cluster 11: RPE1 & U-87MG - Synaptic function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Cytosol Vesicles "HPA008157: AB_1858327, HPA064664: AB_2685315" "unprognostic (6.65e-2)" "unprognostic (4.21e-3)" "unprognostic (1.65e-1)" "prognostic unfavorable (1.90e-4)" "unprognostic (9.39e-2)" "unprognostic (4.13e-1)" "unprognostic (2.18e-3)" "unprognostic (2.55e-1)" "unprognostic (7.52e-2)" "unprognostic (1.63e-1)" "unprognostic (2.02e-1)" "unprognostic (1.82e-1)" "prognostic unfavorable (3.11e-5)" "unprognostic (1.78e-2)" "unprognostic (1.96e-1)" "unprognostic (4.58e-3)" "unprognostic (2.23e-1)" 35.3 20.5 31.7 11.6 33.3 5.5 31.8 32.2 38.6 23.4 34.5 36.6 6.8 38.9 15.5 14.5 21.2 18.8 31.9 37.2 33.6 24.9 22.1 25.7 10.2 28.1 28.1 52.8 20.6 9.1 28.9 11.6 26.6 28.2 13.6 10.2 17.4 11.1 20.9 18.7 27.8 19.2 26.4 38.9 22.9 17.2 31.4 13.3 17.0 17.4 10.6 27.1 20.5 27.2 43.7 15.9 37.2 18.0 78.6 101.0 41.3 40.4 49.2 32.6 36.9 10.3 17.4 10.4 28.0 56.6 79.6 13.0 6.5 19.4 66.6 25.8 8.0 5.5 46.1 13.2 40.0 13.9 14.8 47.6 19.9 114.4 36.4 30.3 28.8 6.8 1.4 6.8 78.7 8.3 0.1 9.5 9.3 4.8 13.7 9.9 22.9 34.2 31.6 20.5 17.1 67.5 34.3 9.0 18.9 47.1 5.3 2.0 66.4 61.4 38.3 44.7 48.4 0.3 2.2 12.9 215.1 8.8 14.8 0.1 0.5 0.0 0.0 0.7 0.1 0.7 0.0 0.0 0.5 1.8 0.0 0.0 0.0 1.6 0.6 1.1 0.3 0.1 31.7 33.3 32.2 38.6 37.2 33.6 28.1 28.1 26.6 26.4 31.4 27.2 33.0 19.2 25.9 205.7 16.6 16.4 13.0 15.6 17.1 30.5 21.9 15.0 19.3 10.0 21.0 11.0 14.6 9.7 5.6 24.8 0.0 21.2 2.9 11.7 24.8 28.7 18.0 6.5 400.9 14.2 22.0 38.9 7.7 34.2 17.7 17.2 14.6 17.1 14.2 28.6 443.4 20.6 14.2 15.4 22.1 6.6 78.6 20.2 5.4 308.2 12.1 7.3 2.1 476.5 80.4 38.5 14.9 42.9 29.2 52.8 9.2 5.4 18.3 2.7 6.6 27.5 20.0 3.5 6.2 7.2 13.8 8.2 3.8 11.7 19.4 20.3 TRIP12 "KIAA0045, TRIPC, ULF" ENSG00000153827 "Thyroid hormone receptor interactor 12" Q14669 2 229763837-229923239 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Autism spectrum disorder, Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 251.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036835, HPA045893" Enhanced Approved "Nuclear speckles" NA NA "Cluster 17: Basophils - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 1: K-562 - Erythropoiesis" "Cluster 44: Endometrium - Transcription" "Nuclear speckles" "HPA036835: AB_2675340, HPA045893: AB_2679486" "unprognostic (1.22e-1)" "unprognostic (4.87e-2)" "unprognostic (2.61e-1)" "unprognostic (3.33e-2)" "unprognostic (6.81e-2)" "unprognostic (1.88e-1)" "prognostic unfavorable (3.60e-4)" "unprognostic (3.37e-3)" "unprognostic (3.49e-3)" "unprognostic (4.87e-2)" "unprognostic (5.21e-2)" "unprognostic (1.11e-1)" "unprognostic (1.22e-1)" "unprognostic (1.62e-1)" "unprognostic (6.83e-2)" "unprognostic (8.80e-2)" "unprognostic (2.01e-2)" 48.2 32.3 20.2 47.1 26.7 53.9 33.6 20.2 31.4 34.8 15.7 40.8 25.6 30.8 33.4 47.6 28.1 33.9 41.5 16.0 25.4 41.3 42.8 33.3 48.2 20.7 20.8 32.7 29.3 45.0 24.8 44.6 22.1 39.9 33.9 34.8 30.2 33.0 81.7 29.3 27.6 38.2 17.9 41.1 39.1 127.7 21.5 60.3 44.5 59.0 56.3 46.3 26.5 30.0 97.1 100.7 96.2 79.0 94.9 106.2 88.3 144.5 103.0 106.9 118.7 80.5 75.3 37.8 96.2 135.6 129.5 76.3 140.5 105.9 159.3 132.4 52.9 264.1 84.4 78.3 76.4 195.8 163.2 88.1 80.3 174.9 108.5 74.9 145.1 88.2 188.2 38.2 122.5 72.5 105.3 68.5 77.0 50.3 47.7 94.8 189.8 33.6 75.7 156.4 94.4 67.5 1.6 51.9 97.7 85.1 48.2 118.3 188.8 133.9 94.7 84.9 115.5 66.4 79.3 119.0 103.8 77.0 116.6 34.0 14.2 23.6 12.9 16.2 13.1 9.6 12.0 12.7 13.4 8.9 9.5 9.7 36.0 13.9 18.7 12.6 19.5 9.8 20.2 26.7 20.2 31.4 16.0 25.4 20.7 20.8 22.1 17.9 21.5 30.0 78.3 89.8 51.2 85.8 43.4 31.0 32.8 36.3 25.6 31.2 41.2 29.8 91.0 34.3 52.8 31.3 52.1 27.0 60.8 57.3 15.6 37.5 119.5 63.5 65.2 59.3 18.6 40.2 147.6 45.1 25.1 43.7 56.6 73.5 39.2 53.1 50.0 54.3 35.1 42.1 130.3 32.5 30.5 89.6 32.2 102.1 34.8 70.8 26.6 122.7 63.9 25.8 56.7 127.2 251.3 57.8 35.0 45.5 52.1 44.7 25.7 34.5 73.1 32.1 19.7 57.5 45.0 137.2 59.3 43.1 36.2 42.4 47.0 60.2 31.9 54.5 TRIT1 "FLJ20061, IPT" ENSG00000043514 "TRNA isopentenyltransferase 1" Q9H3H1 1 39838110-39883511 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "tRNA processing" Transferase "Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA024174, HPA027330" Approved Supported Mitochondria NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 35: Non-specific - Unknown function" "Cluster 1: K-562 - Erythropoiesis" "Cluster 47: Cytotrophoblasts - Unknown function" Mitochondria "HPA024174: AB_1858346, HPA027330: " "unprognostic (4.61e-2)" "unprognostic (1.77e-1)" "unprognostic (8.38e-3)" "prognostic unfavorable (8.80e-4)" "unprognostic (4.00e-2)" "unprognostic (8.55e-2)" "prognostic unfavorable (5.34e-6)" "unprognostic (2.90e-1)" "unprognostic (2.21e-3)" "unprognostic (3.18e-2)" "unprognostic (3.54e-1)" "unprognostic (6.68e-3)" "prognostic unfavorable (7.08e-8)" "unprognostic (6.03e-2)" "unprognostic (1.11e-1)" "unprognostic (1.22e-1)" "unprognostic (6.90e-2)" 9.0 9.9 13.1 7.0 13.1 5.6 12.9 14.7 16.1 15.6 12.8 13.6 6.3 14.7 15.3 18.5 13.1 6.0 15.2 13.1 14.0 15.3 13.0 9.2 8.4 12.1 12.1 14.3 21.5 9.7 16.7 11.8 12.6 19.9 10.5 14.7 13.6 10.9 9.5 21.6 11.1 10.0 12.0 12.6 12.0 11.9 13.9 11.8 16.8 4.4 9.9 15.3 16.8 14.3 20.5 9.4 23.0 18.4 10.6 16.5 29.8 11.1 17.3 22.0 21.8 20.0 20.6 11.5 17.4 11.3 12.2 18.9 29.4 22.7 29.7 17.0 15.6 25.6 22.8 13.5 21.8 21.0 14.4 13.3 21.3 25.0 26.9 25.9 18.0 27.1 31.7 14.1 13.8 11.5 14.3 30.7 31.6 17.4 6.2 21.1 21.6 23.3 21.1 27.3 21.9 16.6 15.2 10.3 17.7 23.0 12.5 37.5 11.0 12.8 18.2 21.1 21.3 19.4 13.2 22.5 14.2 24.6 12.1 0.0 5.4 0.6 2.0 3.9 3.7 2.9 1.8 2.2 10.4 2.2 1.9 2.7 0.2 2.0 5.3 10.1 2.3 2.4 13.1 13.1 14.7 16.1 13.1 14.0 12.1 12.1 12.6 12.0 13.9 14.3 4.9 22.4 7.8 16.6 8.0 14.8 17.1 14.4 10.2 4.6 7.8 9.1 10.8 5.7 11.7 7.3 2.1 34.1 10.3 2.9 7.9 12.2 5.9 13.5 10.8 6.2 10.2 13.3 31.3 9.3 32.8 9.6 3.1 6.1 2.5 9.4 8.9 7.0 8.2 15.2 26.6 8.8 16.2 5.9 5.1 3.1 9.6 7.3 5.4 26.2 12.3 4.9 3.1 34.7 31.3 9.5 5.8 11.3 3.3 8.8 4.5 9.2 25.7 7.3 0.0 8.8 6.9 24.9 16.2 13.2 17.0 16.6 6.1 10.7 9.0 11.2 TRMT1 "FLJ20244, TRM1" ENSG00000104907 "TRNA methyltransferase 1" Q9NXH9 19 13104902-13117567 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "tRNA processing" "Methyltransferase, RNA-binding, Transferase, tRNA-binding" "Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Kupffer cells: 80.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA041130, HPA041380" Approved Approved "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 72: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 57: B-cells - Immune response" "Plasma membrane, Cytosol" Nucleoplasm "HPA041130: AB_10803995, HPA041380: AB_10793873" "unprognostic (2.10e-2)" "unprognostic (2.40e-3)" "unprognostic (2.23e-2)" "unprognostic (1.01e-1)" "unprognostic (1.12e-2)" "unprognostic (5.54e-2)" "unprognostic (1.08e-3)" "unprognostic (2.19e-2)" "unprognostic (1.59e-1)" "unprognostic (7.62e-2)" "unprognostic (1.91e-2)" "unprognostic (8.74e-3)" "prognostic unfavorable (9.87e-7)" "unprognostic (1.19e-3)" "unprognostic (3.47e-2)" "unprognostic (2.22e-1)" "unprognostic (2.49e-2)" 22.0 19.8 16.5 16.2 15.3 21.1 21.0 14.7 22.1 24.3 14.8 20.0 11.8 22.9 6.3 22.3 23.6 8.9 17.3 15.5 14.7 18.0 22.1 17.3 23.2 16.0 14.8 28.7 25.4 10.0 17.2 11.3 16.8 23.0 10.9 6.5 17.0 11.4 28.8 23.4 21.7 12.5 14.2 30.6 18.9 16.8 16.2 11.6 19.2 10.5 15.9 22.3 22.2 17.6 38.6 25.3 26.9 46.0 26.7 34.1 38.7 42.1 20.9 45.3 39.1 27.4 30.8 47.7 53.6 22.9 23.7 34.8 45.2 37.3 20.9 31.3 62.8 38.0 68.7 46.5 48.7 77.2 43.1 48.4 48.4 47.3 44.1 28.9 33.8 35.2 83.7 14.9 28.6 42.6 31.7 83.3 64.0 24.2 57.5 52.5 34.6 65.8 28.3 38.2 63.5 28.9 26.2 53.7 44.8 19.4 21.0 42.8 38.2 65.1 25.5 39.8 75.1 25.6 53.4 44.1 30.3 80.7 34.7 1.8 18.9 0.6 8.9 15.0 8.6 12.4 9.6 8.6 18.2 12.9 11.1 8.5 3.7 5.6 9.9 10.6 6.9 10.7 16.5 15.3 14.7 22.1 15.5 14.7 16.0 14.8 16.8 14.2 16.2 17.6 15.5 12.8 13.1 8.5 47.5 24.0 27.0 16.8 22.8 8.9 16.6 20.2 8.3 11.5 9.6 12.9 2.1 21.7 19.6 16.6 5.9 17.3 22.4 7.9 11.7 17.6 7.2 13.0 12.0 14.9 22.6 14.3 17.9 9.8 29.8 19.7 6.1 10.8 47.7 8.4 9.1 14.1 4.1 80.0 51.0 47.9 14.0 57.4 17.8 10.3 64.8 6.1 12.3 2.5 7.5 12.8 6.8 12.8 24.2 29.0 7.8 14.2 9.2 12.6 13.1 17.5 16.1 21.1 20.0 20.7 20.6 15.5 24.4 14.6 22.5 20.3 TRMT10A "MGC27034, RG9MTD2, TRM10" ENSG00000145331 "TRNA methyltransferase 10A" Q8TBZ6 4 99546709-99564039 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Methyltransferase, Transferase" "Diabetes mellitus, Disease variant, Dwarfism, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Spermatocytes: 99.5;Spermatogonia: 55.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA047601, HPA058241" Uncertain Supported "Nucleoplasm,Nucleoli,Actin filaments,Cytosol" NA NA "Cluster 24: B-cells - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" "Nucleoplasm, Nucleoli, Actin filaments" Cytosol "HPA047601: AB_2680099, HPA058241: AB_2683651" "unprognostic (5.24e-2)" "unprognostic (1.69e-1)" "unprognostic (1.34e-1)" "unprognostic (1.96e-3)" "unprognostic (2.10e-1)" "unprognostic (5.65e-2)" "unprognostic (1.04e-1)" "unprognostic (1.02e-1)" "unprognostic (1.59e-2)" "unprognostic (3.65e-2)" "unprognostic (1.57e-1)" "unprognostic (3.51e-1)" "unprognostic (7.49e-3)" "unprognostic (3.32e-2)" "unprognostic (2.78e-2)" "prognostic unfavorable (2.14e-4)" "unprognostic (1.68e-2)" 4.3 3.7 2.0 3.1 2.6 2.2 4.4 2.6 2.9 1.9 1.5 3.6 4.3 2.7 3.9 3.6 5.8 3.4 2.3 1.8 2.5 4.9 9.8 2.4 4.4 2.6 2.5 3.3 5.9 3.7 2.3 3.7 2.9 4.1 3.6 2.8 3.9 2.2 3.9 3.7 4.5 2.7 2.7 3.5 4.4 9.9 2.4 4.3 6.1 2.7 4.4 2.9 2.0 4.3 8.2 5.4 10.1 5.7 6.0 8.4 7.8 9.6 3.7 5.8 4.1 4.9 9.4 10.9 3.7 5.6 5.9 4.4 10.9 5.1 8.6 13.7 5.4 8.0 4.4 7.6 5.5 19.6 7.8 5.4 14.4 5.7 14.0 3.0 6.4 10.0 17.5 9.4 4.5 9.4 16.4 3.5 6.5 13.8 5.0 9.5 10.2 7.2 8.5 6.8 6.3 5.8 5.3 28.3 9.9 8.5 9.3 7.8 4.9 6.9 7.2 5.5 11.1 7.0 12.4 10.0 4.9 10.9 4.7 2.7 3.9 2.1 1.8 3.8 1.7 3.5 3.3 3.3 5.2 5.8 3.5 3.2 4.9 3.3 3.4 3.0 3.9 1.9 2.0 2.6 2.6 2.9 1.8 2.5 2.6 2.5 2.9 2.7 2.4 4.3 7.2 3.2 10.3 8.8 8.7 8.2 5.6 8.4 10.2 4.3 12.1 8.6 6.4 11.5 6.6 11.0 4.2 16.8 6.1 10.6 43.0 13.8 46.8 33.5 12.1 7.2 7.2 2.1 5.3 19.3 16.4 6.9 8.6 21.6 8.2 11.0 8.2 32.6 8.5 5.0 4.6 11.1 12.2 8.1 4.1 17.0 6.5 5.0 5.4 1.9 8.4 8.7 5.2 3.5 19.7 14.1 11.0 7.5 10.4 4.8 19.0 31.9 20.6 5.9 13.1 5.7 8.1 99.5 55.0 10.2 9.5 17.5 5.5 8.1 10.6 6.6 TRMT10B "bA3J10.9, FLJ31455, RG9MTD3" ENSG00000165275 "TRNA methyltransferase 10B" Q6PF06 9 37753803-37778972 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA021800 Uncertain Approved "Nucleoplasm,Plasma membrane" NA NA "Cluster 46: Basophils - DNA binding" "Cluster 35: Non-specific - Unknown function" "Cluster 20: HeLa - Mitochondria" "Cluster 52: Non-specific - Transcription" Nucleoplasm "Plasma membrane" "HPA021800: AB_1856214" "unprognostic (1.00e-2)" "unprognostic (1.78e-1)" "unprognostic (3.35e-2)" "unprognostic (3.89e-2)" "unprognostic (2.42e-2)" "unprognostic (7.68e-2)" "unprognostic (7.78e-2)" "prognostic favorable (3.91e-4)" "unprognostic (5.49e-3)" "unprognostic (1.71e-2)" "prognostic favorable (5.34e-4)" "unprognostic (1.40e-1)" "unprognostic (6.62e-2)" "unprognostic (1.76e-2)" "unprognostic (1.68e-1)" "unprognostic (9.58e-2)" "unprognostic (2.33e-3)" 5.6 6.9 7.3 5.7 8.1 6.0 6.2 10.7 8.0 8.3 5.8 8.3 4.4 7.1 4.4 5.5 7.6 4.1 4.9 6.8 7.3 6.9 6.4 4.9 7.4 7.9 7.6 9.5 7.9 3.9 6.7 3.8 7.1 8.3 3.5 7.3 6.1 4.2 4.4 10.7 7.1 4.0 6.6 8.1 6.7 3.4 7.6 4.0 7.6 2.1 4.2 7.6 7.1 9.8 4.7 5.6 7.0 6.2 4.2 3.3 3.1 4.4 3.3 4.5 3.9 3.3 4.1 8.7 3.3 3.4 2.7 5.3 3.3 5.5 4.1 3.7 5.6 7.8 14.8 3.5 7.6 8.0 5.2 3.8 5.5 4.3 7.4 5.3 4.7 10.4 6.2 3.6 3.4 3.3 8.1 6.2 6.2 5.0 6.7 8.1 2.4 4.6 4.3 4.2 9.4 9.0 3.7 4.7 4.1 4.4 5.0 5.7 4.8 3.6 5.1 5.9 4.0 4.2 6.1 6.9 2.1 6.1 7.3 3.4 2.7 1.5 3.1 2.4 3.8 3.3 2.8 3.1 1.2 4.3 3.3 3.0 2.8 2.4 1.7 2.3 1.9 1.5 7.3 8.1 10.7 8.0 6.8 7.3 7.9 7.6 7.1 6.6 7.6 9.8 13.2 3.2 8.9 30.3 20.3 7.4 11.4 8.9 15.9 16.2 13.5 16.5 7.4 14.3 8.4 3.7 6.2 16.1 11.0 7.9 11.7 11.3 2.1 7.1 14.1 12.8 13.8 13.7 25.4 12.5 8.6 14.0 13.7 9.1 14.5 17.3 13.6 8.1 8.2 16.8 27.5 14.0 8.2 10.4 9.5 0.9 14.6 12.2 10.6 19.7 15.5 15.9 25.7 37.2 45.7 10.0 6.7 23.7 9.1 14.2 11.4 9.0 7.8 13.5 26.3 13.0 11.1 4.2 5.3 9.7 7.5 12.2 16.4 12.3 10.9 9.4 TRMT10C "FLJ20432, MRPP1, RG9MTD1" ENSG00000174173 "TRNA methyltransferase 10C, mitochondrial RNase P subunit" Q7L0Y3 3 101561868-101566446 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "tRNA processing" "Methyltransferase, Transferase" "Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036671 Approved Supported Nucleoplasm,Mitochondria NA NA "Cluster 44: Non-specific - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 22: Epithelial cell types - Mixed function" Mitochondria Nucleoplasm "HPA036671: AB_10602085" "unprognostic (7.42e-2)" "unprognostic (2.68e-1)" "unprognostic (9.08e-3)" "unprognostic (4.47e-3)" "unprognostic (5.01e-2)" "unprognostic (5.55e-2)" "prognostic unfavorable (6.56e-5)" "unprognostic (1.67e-2)" "unprognostic (8.48e-2)" "unprognostic (5.42e-2)" "unprognostic (4.70e-2)" "unprognostic (3.28e-2)" "prognostic favorable (3.32e-5)" "unprognostic (2.77e-2)" "unprognostic (1.37e-1)" "unprognostic (1.04e-1)" "unprognostic (1.05e-2)" 16.6 17.4 6.9 14.8 7.9 18.2 20.8 9.1 9.7 12.2 8.5 15.4 12.7 14.1 13.4 18.9 14.5 11.4 21.6 7.8 7.9 19.2 25.2 10.3 20.5 7.4 7.4 15.7 10.4 15.6 6.4 14.0 7.9 11.9 14.7 7.8 13.0 9.9 27.6 12.7 13.1 16.0 7.4 12.5 12.1 11.8 7.5 17.5 15.4 30.2 20.7 26.6 8.6 7.5 58.9 28.2 36.6 37.1 33.0 28.0 34.1 34.2 33.3 43.6 48.5 43.2 38.6 121.3 43.4 21.6 35.4 57.9 71.5 52.5 59.7 43.8 35.3 81.6 20.5 31.6 25.4 72.5 33.1 32.9 53.3 38.3 35.4 23.2 43.1 45.4 70.3 26.3 47.6 40.4 58.2 52.9 68.2 75.9 60.4 42.9 29.8 54.3 56.2 49.0 90.9 51.8 26.7 56.0 78.1 31.9 74.0 78.9 28.7 23.6 45.0 15.8 36.5 30.4 59.4 117.5 40.0 51.5 36.2 56.6 18.2 12.8 21.1 24.7 29.8 35.7 26.2 25.1 22.7 34.2 35.0 33.2 8.1 21.4 27.4 25.8 26.2 19.5 6.9 7.9 9.1 9.7 7.8 7.9 7.4 7.4 7.9 7.4 7.5 7.5 33.3 22.4 24.0 4.9 47.9 94.3 153.4 106.8 63.7 30.6 39.9 52.7 51.5 21.5 69.2 29.5 14.6 65.7 50.3 21.5 52.8 48.5 49.7 54.7 54.0 39.5 35.8 65.0 8.8 33.8 47.0 38.8 28.1 63.5 46.3 47.3 31.4 56.9 31.1 21.9 8.5 31.5 69.2 27.3 31.9 13.7 37.3 23.7 14.2 1.9 42.1 29.8 37.0 6.6 7.6 37.2 17.9 37.6 21.5 85.3 17.3 72.0 53.3 33.9 32.9 58.1 41.3 77.7 55.0 55.2 105.0 65.5 46.4 57.1 47.0 127.4 TRMT12 "FLJ20772, Trm12, TYW2" ENSG00000183665 "TRNA methyltransferase 12 homolog" Q53H54 8 124450820-124462150 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "tRNA processing" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "MCF7: 73.1" "Low region specificity" "Detected in all" HPA023939 Approved Approved Nucleoplasm,Mitochondria No No "Cluster 22: NK-cells - Unknown function" "Cluster 52: Non-specific - Ribosome" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 66: Spermatocytes - Spermatogenesis" Nucleoplasm Mitochondria "HPA023939: AB_1848793" "unprognostic (2.54e-2)" "unprognostic (2.20e-1)" "unprognostic (7.81e-2)" "unprognostic (1.02e-2)" "unprognostic (8.75e-2)" "prognostic unfavorable (2.99e-5)" "prognostic unfavorable (5.10e-4)" "unprognostic (6.89e-2)" "unprognostic (1.99e-1)" "unprognostic (1.28e-1)" "unprognostic (1.51e-1)" "unprognostic (6.56e-2)" "unprognostic (4.72e-3)" "unprognostic (3.39e-2)" "unprognostic (2.40e-1)" "prognostic unfavorable (9.25e-4)" "unprognostic (1.04e-2)" 6.0 5.8 5.0 5.4 5.1 3.1 8.7 4.3 6.7 6.5 5.5 5.7 4.6 6.5 6.1 5.6 7.6 4.4 5.9 6.5 4.8 7.6 6.0 5.9 6.5 3.6 3.9 5.0 5.1 8.6 4.7 5.4 4.1 6.9 6.5 8.1 7.7 6.1 9.7 5.3 5.0 8.2 3.4 5.5 5.7 6.4 5.5 8.3 8.8 10.0 6.7 6.7 4.3 4.9 14.8 12.6 10.3 8.1 19.0 9.7 2.5 9.1 10.6 13.1 11.2 7.7 10.0 14.9 12.3 9.4 8.5 10.1 14.7 14.9 15.4 14.8 11.2 14.4 12.8 2.6 14.8 0.0 11.2 12.1 19.6 12.9 16.2 3.8 11.1 15.4 20.4 10.1 8.2 73.1 17.2 6.1 0.0 33.9 11.5 5.4 6.9 9.9 12.1 15.7 17.3 13.8 13.4 49.5 19.5 8.7 14.1 6.1 8.9 9.1 23.8 6.8 10.4 10.4 15.6 5.8 8.2 5.0 7.5 0.4 3.5 3.8 2.3 2.9 3.0 2.1 3.2 2.5 2.8 2.8 3.9 3.9 1.3 3.1 3.3 0.8 2.1 2.4 5.0 5.1 4.3 6.7 6.5 4.8 3.6 3.9 4.1 3.4 5.5 4.9 4.9 9.6 7.5 2.0 11.2 5.2 6.1 3.5 7.4 5.6 5.5 4.7 3.9 7.2 2.2 3.7 16.7 7.3 8.4 4.2 5.9 5.6 18.6 6.3 4.9 5.7 3.0 1.7 1.5 6.2 5.4 4.5 6.6 3.6 9.5 7.7 4.2 5.4 5.1 8.4 1.8 4.4 4.1 4.1 2.5 21.0 4.1 5.2 5.4 1.0 8.1 4.0 9.2 1.0 1.2 4.3 3.9 6.0 8.4 4.8 3.9 8.2 7.6 8.2 0.0 8.2 6.5 14.2 5.8 4.7 4.3 4.9 6.3 7.9 4.9 4.6 TRMT13 "CCDC76, FLJ10287, FLJ11219" ENSG00000122435 "TRNA methyltransferase 13 homolog" Q9NUP7 1 100133150-100150498 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "tRNA processing" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 97.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA028494 Approved Approved "Nucleoplasm,Nuclear bodies,Plasma membrane,Cytosol" NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 34: Non-specific - Transcription" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 52: Non-specific - Transcription" "Nucleoplasm, Plasma membrane" "Nuclear bodies, Cytosol" "HPA028494: AB_10601254" "unprognostic (1.12e-1)" "unprognostic (3.33e-1)" "unprognostic (5.76e-2)" "unprognostic (2.37e-1)" "unprognostic (9.17e-3)" "unprognostic (4.97e-2)" "prognostic unfavorable (5.81e-5)" "unprognostic (1.16e-3)" "unprognostic (3.28e-2)" "unprognostic (8.08e-2)" "unprognostic (3.22e-1)" "unprognostic (1.02e-3)" "prognostic unfavorable (6.89e-6)" "unprognostic (3.12e-2)" "unprognostic (7.71e-2)" "unprognostic (1.99e-2)" "unprognostic (1.70e-3)" 8.8 8.7 6.9 12.2 9.8 5.2 14.5 9.6 9.6 11.2 6.7 9.3 11.2 13.9 11.8 8.5 9.2 7.2 8.0 6.5 9.7 8.8 8.7 7.8 18.2 8.5 9.0 13.5 11.5 12.9 6.8 10.7 8.7 10.4 11.3 21.7 9.1 8.1 13.1 14.7 10.7 10.1 7.0 14.1 10.0 9.4 8.5 11.3 12.0 6.2 14.6 9.5 10.3 14.9 17.5 10.0 16.5 11.5 8.7 16.9 18.0 18.0 7.1 13.4 11.1 11.9 7.0 28.7 21.8 14.4 8.9 15.4 30.6 14.0 23.1 29.0 24.2 17.2 23.1 11.6 15.7 30.0 15.4 11.9 15.5 25.5 33.3 8.4 12.4 21.0 36.6 17.9 13.6 6.7 24.6 15.6 23.0 16.7 19.9 26.0 25.0 15.7 11.1 13.6 10.7 17.9 16.6 15.8 21.6 16.1 9.3 26.1 13.0 17.8 11.9 15.1 24.3 22.8 20.0 34.0 20.1 23.5 7.0 0.2 5.8 3.1 10.5 6.1 13.0 19.9 11.3 10.6 7.0 18.7 16.8 14.0 2.5 7.9 5.1 12.8 8.6 5.6 6.9 9.8 9.6 9.6 6.5 9.7 8.5 9.0 8.7 7.0 8.5 14.9 13.1 25.6 17.0 34.0 29.0 9.7 14.2 14.2 19.9 38.9 10.7 7.9 11.1 12.8 22.2 14.7 29.2 14.2 18.9 8.0 13.7 10.5 20.9 14.3 21.0 15.7 20.4 11.3 23.1 6.1 10.2 13.7 11.7 8.0 21.5 18.7 17.9 11.4 7.6 28.6 32.1 9.9 18.3 10.1 7.0 6.0 24.8 10.3 10.6 25.3 14.7 16.6 41.2 33.7 97.4 8.5 9.6 18.4 9.0 12.6 13.0 10.7 20.4 44.7 19.7 16.0 13.4 47.6 21.9 12.2 11.9 7.3 21.5 15.8 13.6 10.0 TRMT2B "CXorf34, FLJ12687" ENSG00000188917 "TRNA methyltransferase 2 homolog B" Q96GJ1 X 101009346-101052116 "Enzymes, Predicted intracellular proteins" "tRNA processing" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003745, HPA035120, HPA040814" Uncertain Approved "Nucleoplasm,Nuclear bodies" NA NA "Cluster 44: Non-specific - Transcription" "Cluster 8: Non-specific - Mitochondria" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 52: Non-specific - Transcription" Nucleoplasm "Nuclear bodies" "HPA003745: AB_2667047, HPA035120: AB_10601702, HPA040814: " "prognostic unfavorable (1.58e-5)" "unprognostic (6.72e-3)" "unprognostic (3.28e-1)" "unprognostic (1.54e-2)" "unprognostic (4.44e-1)" "unprognostic (8.74e-2)" "unprognostic (3.52e-2)" "unprognostic (8.16e-3)" "unprognostic (5.77e-2)" "unprognostic (2.01e-1)" "unprognostic (8.80e-2)" "unprognostic (2.78e-2)" "prognostic favorable (2.30e-7)" "unprognostic (4.58e-2)" "unprognostic (4.82e-1)" "unprognostic (5.03e-2)" "unprognostic (1.60e-2)" 5.4 6.4 3.3 7.1 3.3 7.8 6.3 3.7 4.0 6.8 5.6 7.8 6.1 4.7 4.0 8.2 5.3 5.4 9.1 3.3 3.8 8.7 6.2 6.5 10.3 4.3 3.9 6.7 6.4 14.7 5.8 3.9 4.7 6.6 9.2 2.4 9.9 5.3 15.0 6.9 9.2 5.0 3.4 10.6 8.7 2.5 4.0 14.7 8.6 14.4 11.3 5.2 6.1 3.3 22.4 18.9 3.8 8.9 8.7 4.5 11.6 11.4 15.4 12.6 18.7 20.6 17.5 19.9 22.3 10.6 25.6 13.7 17.5 16.0 15.7 17.2 10.9 12.6 15.6 9.9 7.6 22.5 19.6 5.8 9.3 18.2 8.4 8.8 24.8 21.2 13.0 18.3 11.7 22.5 28.5 11.6 5.2 27.7 14.0 22.8 18.2 19.1 9.2 12.8 5.5 7.4 19.4 14.0 11.7 10.4 9.1 10.8 14.5 15.7 9.4 14.8 10.3 11.5 18.7 18.1 12.2 25.3 12.4 14.9 10.0 18.8 15.8 8.0 17.0 18.7 18.6 15.8 9.3 20.4 21.8 18.3 5.7 18.7 9.5 10.0 16.8 14.8 3.3 3.3 3.7 4.0 3.3 3.8 4.3 3.9 4.7 3.4 4.0 3.3 3.0 6.4 6.3 22.2 10.5 2.3 5.5 4.1 6.2 0.8 3.0 1.5 10.3 1.5 5.0 14.7 2.1 6.1 5.7 5.4 7.9 4.0 0.1 3.3 1.9 4.0 6.7 5.7 17.2 3.4 3.0 3.4 6.1 2.9 13.3 6.9 3.6 4.1 3.6 1.7 18.5 6.8 2.0 5.3 0.6 0.8 3.4 3.4 1.8 18.7 5.6 4.8 14.4 9.5 11.6 5.3 4.8 3.8 4.2 3.8 5.5 5.7 6.0 1.8 0.0 5.3 3.0 0.2 3.8 6.2 1.6 5.1 8.7 4.4 6.1 5.3 TRMT44 "C4orf23, FLJ35725, METTL19, TRM44" ENSG00000155275 "TRNA methyltransferase 44 homolog" Q8IYL2 4 8436140-8493531 "Enzymes, Predicted intracellular proteins" "tRNA processing" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA045461 Uncertain Approved Nucleoplasm NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 31: Skin - Epidermis development" "Cluster 28: BEWO - Transcription regulation" "Cluster 44: Endometrium - Transcription" Nucleoplasm "HPA045461: AB_10961276" "unprognostic (1.50e-1)" "unprognostic (1.65e-3)" "unprognostic (3.47e-1)" "unprognostic (1.01e-2)" "unprognostic (2.06e-1)" "unprognostic (1.34e-2)" "unprognostic (1.75e-1)" "unprognostic (1.78e-2)" "unprognostic (3.46e-1)" "unprognostic (8.13e-2)" "unprognostic (3.44e-3)" "unprognostic (2.69e-3)" "unprognostic (1.49e-1)" "unprognostic (1.16e-2)" "unprognostic (1.28e-1)" "unprognostic (6.76e-2)" "unprognostic (8.34e-3)" 5.8 3.5 2.0 3.9 2.5 7.1 6.9 2.6 2.8 5.1 0.7 4.9 3.6 6.2 4.4 6.6 5.4 3.4 4.6 2.2 0.9 3.2 4.2 4.2 5.0 0.9 0.6 7.6 4.5 4.2 3.2 4.9 1.2 4.8 3.2 3.7 5.5 3.8 5.9 9.0 3.6 4.4 0.6 4.0 5.3 4.9 1.3 3.7 4.5 2.6 5.2 5.0 5.6 2.6 5.2 5.1 6.4 7.5 6.5 6.3 15.2 5.9 4.2 7.6 6.7 6.8 7.0 6.9 3.1 2.3 6.4 4.1 9.3 5.4 6.7 3.7 5.9 6.9 8.9 5.1 6.0 11.4 4.9 3.9 7.7 5.8 6.3 6.4 8.1 4.8 10.2 7.2 5.0 3.2 9.5 8.3 7.4 6.5 8.5 6.9 6.9 4.9 6.6 6.0 6.9 4.7 3.8 3.4 5.5 7.2 2.9 4.7 5.2 4.6 2.5 4.4 9.3 8.4 6.0 6.2 5.1 10.7 4.7 0.1 0.3 0.0 0.6 0.3 0.3 0.2 0.5 0.6 0.5 0.5 0.7 0.2 0.0 0.2 0.6 0.4 0.0 0.1 2.0 2.5 2.6 2.8 2.2 0.9 0.9 0.6 1.2 0.6 1.3 2.6 4.4 9.6 7.3 12.7 4.9 6.8 4.2 3.1 2.8 7.8 6.8 5.1 3.3 7.2 3.2 7.3 25.0 10.2 4.1 2.6 5.9 5.0 3.8 16.2 13.0 4.7 1.8 1.7 21.3 4.5 6.2 7.5 14.8 25.6 5.1 18.8 5.0 3.8 4.6 3.3 18.4 2.0 2.0 3.1 2.4 2.8 5.9 3.7 1.8 8.4 4.1 2.6 3.1 8.5 12.3 4.5 7.2 3.8 5.3 5.3 3.0 2.7 8.1 10.8 0.0 6.3 6.5 9.2 5.8 8.2 5.8 16.3 5.2 4.8 3.8 7.6 TRMT5 "KIAA1393, TRM5" ENSG00000126814 "TRNA methyltransferase 5" Q32P41 14 60971441-60981170 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "tRNA processing" "Methyltransferase, Transferase" "Disease variant, Primary mitochondrial disease" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in all" 4 "Early spermatids: 221.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000943 Supported Approved Nucleoplasm,Nucleoli NA NA "Cluster 24: B-cells - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 30: Epithelial cell lines - Translation" "Cluster 29: Early spermatids - Spermatogenesis" "Nucleoplasm, Nucleoli" "HPA000943: AB_1080388" "unprognostic (1.58e-2)" "unprognostic (3.62e-2)" "unprognostic (6.63e-3)" "unprognostic (1.11e-2)" "unprognostic (7.70e-3)" "unprognostic (2.26e-2)" "unprognostic (7.82e-3)" "unprognostic (4.50e-2)" "unprognostic (3.95e-1)" "unprognostic (1.78e-1)" "unprognostic (1.47e-1)" "unprognostic (2.84e-2)" "unprognostic (1.60e-3)" "unprognostic (1.82e-1)" "unprognostic (1.97e-2)" "unprognostic (2.10e-2)" "unprognostic (1.40e-1)" 7.3 5.5 3.5 4.4 3.8 4.8 9.8 6.0 4.1 6.5 3.1 6.7 5.7 7.0 7.8 7.6 7.4 5.1 4.2 3.4 4.6 6.9 6.8 5.0 6.0 2.5 3.4 9.9 6.7 10.5 3.5 7.0 2.8 6.9 6.0 5.2 7.6 4.8 7.5 6.7 4.5 7.0 3.1 4.7 5.8 17.3 4.0 6.1 7.2 7.2 5.8 6.7 3.9 3.8 49.7 12.5 17.9 25.0 15.5 23.6 19.4 18.2 14.0 19.1 15.2 9.8 28.7 25.2 19.9 13.3 14.3 22.3 22.9 26.4 25.0 25.3 11.5 18.6 8.1 10.2 25.1 33.2 9.9 18.3 25.1 17.4 25.4 17.0 17.0 21.6 24.5 8.8 28.3 18.7 17.1 16.8 16.4 19.4 20.3 5.4 41.5 21.4 16.3 16.7 22.1 21.6 20.2 20.1 16.6 15.4 33.5 19.7 16.1 22.1 26.7 15.7 17.5 5.3 10.8 11.6 15.6 7.2 21.0 0.1 3.2 0.7 2.4 5.5 3.3 4.9 3.4 3.5 3.0 4.1 3.8 3.4 0.3 1.4 5.9 5.2 4.5 2.5 3.5 3.8 6.0 4.1 3.4 4.6 2.5 3.4 2.8 3.1 4.0 3.8 7.0 6.4 10.9 3.9 4.5 6.4 19.5 15.9 9.6 5.7 6.3 10.0 8.0 1.5 19.6 11.0 4.2 12.8 5.7 3.2 1.9 7.7 221.8 8.2 17.4 9.2 5.4 10.7 5.4 7.5 12.4 12.4 9.7 8.1 6.3 12.1 8.6 7.0 10.9 3.3 6.7 8.3 8.2 6.2 7.6 50.2 11.1 6.0 7.2 3.7 4.1 12.2 1.0 9.0 6.3 8.2 4.8 7.5 4.7 8.2 3.9 11.1 14.9 5.4 13.1 14.7 9.5 23.3 12.6 11.1 4.3 19.2 5.2 14.4 7.6 10.6 TRMT61A "C14orf172, FLJ40452, GCD14, Gcd14p, hTRM61" ENSG00000166166 "TRNA methyltransferase 61A" Q96FX7 14 103529196-103537073 "Enzymes, Predicted intracellular proteins" "tRNA processing" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Cardiomyocytes: 62.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "non-classical monocyte: 10.8" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA024269 Approved Mitochondria NA NA "Cluster 51: Monocytes - Innate immune response" "Cluster 35: Non-specific - Unknown function" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 43: Cardiomyocytes - Nuclear processes" Mitochondria "HPA024269: " "unprognostic (5.12e-2)" "unprognostic (2.73e-2)" "unprognostic (1.36e-1)" "unprognostic (5.59e-3)" "unprognostic (1.49e-1)" "unprognostic (3.70e-2)" "prognostic unfavorable (1.60e-4)" "unprognostic (1.94e-1)" "unprognostic (3.29e-1)" "unprognostic (2.20e-1)" "unprognostic (3.70e-2)" "unprognostic (9.86e-3)" "unprognostic (2.88e-3)" "unprognostic (4.16e-1)" "unprognostic (2.79e-1)" "unprognostic (1.42e-1)" "unprognostic (1.28e-1)" 10.5 10.0 11.2 4.5 13.6 4.5 9.6 11.2 14.4 15.2 8.1 24.3 4.4 18.7 2.3 9.7 18.9 2.4 7.5 10.9 10.0 13.9 11.6 8.1 3.7 11.9 11.6 10.8 11.0 3.0 7.5 2.7 11.0 17.1 1.7 1.5 7.4 7.0 9.9 10.8 9.6 4.3 10.7 7.6 12.4 8.3 11.7 2.3 15.3 2.6 1.8 21.3 11.2 12.8 10.0 24.4 3.7 7.6 3.8 3.9 15.1 10.8 4.8 13.3 7.2 33.4 16.8 16.1 13.3 5.7 7.8 25.2 8.0 8.3 3.7 11.0 15.0 12.3 9.6 18.0 6.7 15.9 9.2 4.4 10.4 11.6 4.7 3.1 2.3 11.4 18.5 7.6 4.5 28.9 19.6 12.2 12.9 20.7 48.8 24.0 11.6 13.9 5.4 14.5 19.4 12.2 12.4 11.5 14.7 1.4 21.5 9.3 4.6 12.0 12.8 31.9 22.4 10.2 7.0 20.2 12.8 12.7 23.3 0.0 2.1 0.3 2.6 5.4 1.9 2.5 2.1 2.8 3.3 2.6 2.3 2.3 0.0 2.7 10.8 2.2 1.6 2.2 11.2 13.6 11.2 14.4 10.9 10.0 11.9 11.6 11.0 10.7 11.7 12.8 9.8 0.0 6.0 4.9 11.0 26.1 19.9 7.7 6.8 13.7 11.5 13.5 62.7 7.2 4.7 7.3 4.2 13.0 7.2 19.2 17.6 19.4 4.0 6.0 15.7 10.6 10.7 2.5 4.1 12.2 15.5 13.6 8.2 7.2 2.5 12.6 3.9 9.9 12.3 30.3 3.2 10.4 4.1 7.8 7.8 18.9 11.1 6.6 10.6 2.8 12.8 9.4 4.1 0.5 4.8 19.7 9.3 18.4 6.3 22.8 6.3 15.7 5.0 11.2 0.0 12.5 15.4 6.9 12.5 8.5 30.0 12.0 7.0 10.7 19.4 13.6 TRMT61B FLJ20628 ENSG00000171103 "TRNA methyltransferase 61B" Q9BVS5 2 28849821-28870309 "Enzymes, Predicted intracellular proteins" "tRNA processing" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026747, HPA026751" Enhanced Uncertain Cytosol NA NA "Cluster 15: NK-cells - Transcription" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" Cytosol "HPA026747: AB_1848782, HPA026751: AB_1848784" "unprognostic (1.01e-2)" "unprognostic (1.32e-2)" "unprognostic (1.63e-3)" "unprognostic (2.05e-2)" "unprognostic (3.32e-2)" "unprognostic (4.14e-2)" "prognostic unfavorable (3.61e-4)" "unprognostic (2.36e-2)" "unprognostic (2.55e-2)" "unprognostic (2.77e-1)" "unprognostic (2.52e-2)" "unprognostic (2.52e-2)" "prognostic favorable (9.61e-5)" "unprognostic (2.19e-1)" "unprognostic (1.43e-1)" "unprognostic (5.38e-2)" "unprognostic (2.34e-1)" 8.8 13.1 9.8 8.5 9.9 9.2 13.1 12.1 17.0 9.4 12.0 8.4 14.1 10.1 14.0 8.6 8.1 7.2 15.2 9.8 9.9 14.4 12.6 6.6 11.0 9.7 9.8 9.4 7.0 15.1 9.0 8.9 10.0 10.6 9.3 9.4 8.7 7.9 13.8 8.7 14.1 10.3 9.8 8.7 9.2 7.4 9.7 10.2 9.1 16.6 9.1 10.7 7.5 10.6 28.5 16.7 16.7 29.6 22.3 19.0 20.1 16.5 20.3 20.6 19.2 19.3 15.0 29.9 14.8 14.5 24.7 21.7 23.5 20.1 21.3 22.6 15.8 9.1 13.6 25.7 25.2 19.4 10.0 19.5 22.0 16.4 22.2 15.2 20.0 19.1 18.9 11.2 17.2 11.3 17.3 29.6 31.0 33.6 26.7 12.7 26.9 26.1 18.2 18.2 28.1 29.8 17.8 27.8 28.5 13.9 14.2 6.7 15.8 13.7 23.1 13.6 21.0 13.7 24.2 46.6 18.1 28.9 18.8 0.0 8.0 3.5 11.2 8.5 13.8 14.5 12.4 12.0 7.8 14.1 13.7 9.9 1.1 17.7 7.1 8.3 14.7 7.4 9.8 9.9 12.1 17.0 9.8 9.9 9.7 9.8 10.0 9.8 9.7 10.6 10.2 16.0 8.7 18.3 17.7 18.1 11.0 23.7 17.1 10.8 9.9 10.2 2.8 11.5 14.7 9.2 6.2 22.1 11.8 4.5 15.6 14.5 9.3 9.4 11.8 8.5 4.8 10.9 38.0 10.2 13.8 10.8 21.4 7.7 9.5 15.8 7.5 11.5 9.2 6.7 34.8 9.8 20.3 7.3 8.2 3.6 8.7 7.0 7.2 7.5 11.0 10.3 8.2 36.2 32.2 10.3 8.5 10.5 13.5 7.6 23.6 30.3 15.0 21.6 6.6 12.2 10.6 24.1 9.7 15.3 15.8 8.8 12.4 15.9 12.1 7.3 TRMU "FLJ10140, MTO2, MTU1, TRMT" ENSG00000100416 "TRNA mitochondrial 2-thiouridylase" O75648 22 46330875-46357340 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "tRNA processing" "RNA-binding, Transferase, tRNA-binding" "Deafness, Disease variant, Non-syndromic deafness" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000824, HPA035273, HPA043300" Uncertain Supported Mitochondria NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 39: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 52: Non-specific - Transcription" Mitochondria "HPA000824: AB_2732393, HPA035273: AB_10602901, HPA043300: AB_2678415" "unprognostic (2.96e-1)" "unprognostic (1.09e-2)" "unprognostic (8.07e-2)" "unprognostic (4.27e-2)" "unprognostic (2.64e-1)" "unprognostic (3.52e-3)" "prognostic unfavorable (3.04e-5)" "unprognostic (4.72e-2)" "unprognostic (7.14e-2)" "unprognostic (7.89e-2)" "prognostic favorable (6.86e-4)" "unprognostic (4.74e-3)" "prognostic unfavorable (5.63e-6)" "unprognostic (7.26e-2)" "unprognostic (1.73e-1)" "unprognostic (3.56e-1)" "unprognostic (7.44e-3)" 4.2 7.5 7.7 2.3 7.8 2.9 4.0 8.3 9.6 4.3 8.3 4.5 4.7 3.6 7.5 5.6 3.4 2.6 11.2 7.6 8.5 9.1 8.8 3.5 5.0 8.5 8.6 4.0 10.2 8.0 5.3 4.1 8.5 4.4 4.1 2.8 5.5 4.7 6.9 4.8 4.0 3.9 7.9 4.2 4.3 2.3 8.5 3.0 4.6 8.4 4.3 4.2 4.1 7.8 17.8 16.0 6.6 15.1 12.2 8.6 16.6 18.1 12.6 24.9 19.2 22.7 4.5 11.5 12.5 16.2 10.9 15.3 28.5 16.0 21.1 7.5 38.4 13.6 25.0 27.1 10.4 26.5 9.0 8.2 17.6 25.8 8.1 10.3 16.2 5.8 19.3 2.7 15.3 19.1 10.4 21.5 25.5 10.6 27.5 12.2 14.4 21.2 12.5 12.1 15.9 19.0 16.0 18.5 31.7 8.2 10.7 10.9 11.9 11.1 19.8 15.8 20.7 6.5 7.8 12.6 15.7 19.1 22.8 0.0 6.2 3.8 9.4 9.0 8.3 5.4 8.2 8.9 7.1 5.5 7.3 6.9 1.3 8.0 9.8 5.8 11.0 5.9 7.7 7.8 8.3 9.6 7.6 8.5 8.5 8.6 8.5 7.9 8.5 7.8 12.7 9.6 6.1 22.9 13.2 6.2 10.8 16.8 7.4 26.4 10.6 11.8 14.7 10.0 10.7 11.0 16.7 24.9 16.1 14.1 27.4 20.1 1.6 6.3 10.2 14.5 12.5 14.3 19.4 19.6 21.0 11.9 21.9 6.6 9.5 26.8 13.9 16.8 15.9 13.5 18.0 12.3 10.2 9.9 4.0 3.3 15.2 8.8 8.8 5.6 14.9 11.9 20.6 10.1 14.6 19.5 9.9 17.0 13.8 14.2 15.3 27.9 10.2 26.4 6.6 7.6 14.4 18.5 12.9 9.6 9.7 15.3 13.1 21.0 19.3 9.9 TRNT1 "CCA1, CGI-47, MtCCA" ENSG00000072756 "TRNA nucleotidyl transferase 1" Q96Q11 3 3126933-3150879 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "tRNA processing" "Nucleotidyltransferase, RNA-binding, Transferase" "Disease variant, Retinitis pigmentosa" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA036938 Uncertain Supported Mitochondria Yes No "Cluster 46: Basophils - DNA binding" "Cluster 7: Kidney - Transmembrane transport" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 59: Non-specific - Transcription" Mitochondria "HPA036938: AB_10670566" "unprognostic (6.39e-3)" "unprognostic (1.58e-1)" "unprognostic (2.38e-3)" "unprognostic (4.69e-2)" "unprognostic (4.92e-2)" "unprognostic (2.41e-1)" "unprognostic (1.39e-2)" "unprognostic (2.68e-1)" "unprognostic (6.22e-2)" "unprognostic (5.65e-2)" "unprognostic (4.62e-2)" "unprognostic (1.41e-2)" "unprognostic (1.24e-2)" "unprognostic (6.50e-2)" "unprognostic (1.09e-1)" "unprognostic (3.78e-1)" "unprognostic (1.02e-1)" 9.7 10.0 7.2 8.9 7.2 3.5 8.5 7.9 8.0 7.8 7.0 8.1 4.4 8.8 5.5 9.4 7.6 8.3 8.4 7.4 7.2 17.2 10.0 8.4 9.7 7.1 7.3 8.3 8.4 8.3 10.3 10.5 7.1 11.3 7.6 4.0 7.7 6.3 9.3 6.4 7.9 8.3 7.3 10.7 9.1 6.5 7.4 9.8 11.3 7.6 10.9 13.1 7.9 8.0 20.0 29.6 18.2 9.8 24.1 21.5 20.5 19.9 17.4 21.6 20.9 25.0 20.9 35.6 12.8 22.4 32.0 12.6 24.6 18.6 26.5 24.6 13.3 28.7 25.3 24.9 31.4 32.2 20.8 17.9 25.0 20.2 6.8 15.0 21.0 24.1 25.1 9.8 35.9 37.2 22.0 21.4 15.2 29.2 19.0 20.5 28.1 32.5 26.1 25.8 10.8 15.9 31.6 20.6 18.5 26.3 18.7 16.3 14.8 22.8 18.7 23.6 25.7 12.6 31.4 43.4 17.2 27.6 25.0 49.4 12.4 36.4 16.4 18.1 16.0 25.8 20.8 18.1 16.8 15.7 22.7 20.1 16.6 19.8 19.0 15.6 18.6 11.2 7.2 7.2 7.9 8.0 7.4 7.2 7.1 7.3 7.1 7.3 7.4 8.0 20.7 16.0 13.4 15.3 30.2 14.8 29.0 19.9 24.5 13.5 12.1 11.0 14.3 2.8 16.3 18.4 14.6 25.8 23.5 10.6 45.0 19.1 2.3 15.8 19.0 21.1 8.4 16.6 23.8 9.9 17.8 19.9 23.4 12.0 22.8 20.7 12.5 9.2 13.3 10.1 27.0 10.7 16.2 11.0 13.3 2.9 10.8 13.3 7.2 23.4 20.3 17.1 18.6 23.6 34.7 10.6 9.2 8.6 30.7 30.9 11.0 32.7 11.4 15.7 0.0 14.9 17.4 20.8 17.9 23.4 13.1 28.3 22.0 24.7 13.5 23.9 TRPM6 "CHAK2, FLJ22628, HOMG, HSH" ENSG00000119121 "Transient receptor potential cation channel subfamily M member 6" Q9BX84 9 74722495-74888094 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Transport" "Calcium channel, Ion channel, Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant, Primary hypomagnesemia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 4 "brain: 6.6;intestine: 16.6" "Cell type enhanced" "Detected in many" "Distal enterocytes: 128.9;Glandular and luminal cells: 36.5;Microglial cells: 39.4;Oligodendrocytes: 81.1;Proximal enterocytes: 23.3" "Cancer enhanced" "Detected in some" "testis cancer: 1.8" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 6 "basophil: 23.1;neutrophil: 7.5" "Lineage enriched" "Detected in single" 41 "granulocytes: 23.1" "Cell line enhanced" "Detected in some" "BEWO: 3.8;HeLa: 2.4;Karpas-707: 1.3;RT4: 3.8;U-266/70: 1.4" "Low region specificity" "Detected in single" "Low region specificity" "Detected in all" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 45: Intestine - Brush border" "Cluster 15: RT4 - Unknown function" "Cluster 53: Intestinal epithelial cells - Unknown function" "unprognostic (3.95e-2)" "unprognostic (1.46e-1)" "unprognostic (1.76e-1)" "unprognostic (1.65e-1)" "unprognostic (7.80e-2)" "unprognostic (9.20e-2)" "unprognostic (1.59e-2)" "unprognostic (1.72e-1)" "unprognostic (2.82e-1)" "unprognostic (1.84e-1)" "unprognostic (5.72e-4)" "unprognostic (1.58e-1)" "unprognostic (1.71e-2)" "unprognostic (8.10e-2)" "unprognostic (7.54e-2)" "unprognostic (1.89e-2)" "unprognostic (2.11e-2)" 0.6 0.0 2.1 0.6 3.5 2.6 0.6 3.0 2.4 0.3 0.2 13.2 7.0 0.3 0.2 0.3 0.2 0.3 0.2 1.6 2.8 1.9 0.1 0.3 0.3 4.2 3.4 0.0 0.1 1.4 0.5 0.3 4.1 0.5 16.6 0.4 0.3 0.1 0.1 0.7 7.9 0.5 2.7 0.5 0.2 1.4 3.1 0.4 0.2 0.1 0.3 0.4 0.3 6.6 0.0 0.8 0.1 0.0 0.0 0.0 3.8 0.0 0.0 0.0 0.0 1.0 0.1 0.3 0.0 0.0 0.1 0.1 0.2 0.2 0.0 0.0 0.1 0.1 2.4 0.1 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.1 0.1 0.0 1.3 0.0 0.5 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.1 0.0 3.8 0.1 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.1 0.5 0.1 0.0 1.4 0.0 0.1 0.0 0.1 0.1 23.1 0.1 2.4 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.3 0.1 0.1 7.5 0.5 0.2 0.3 0.0 0.1 2.1 3.5 3.0 2.4 1.6 2.8 4.2 3.4 4.1 2.7 3.1 6.6 3.3 0.0 1.7 1.0 0.3 0.1 1.9 0.3 2.2 0.3 0.2 0.4 0.9 0.0 1.3 3.7 0.0 0.2 0.2 128.9 0.0 0.0 4.0 11.3 3.4 3.2 3.6 0.0 1.3 0.0 0.1 0.3 0.0 36.5 0.0 0.1 3.3 0.1 0.0 0.0 0.5 3.0 0.0 0.3 0.6 0.9 0.0 0.4 0.0 39.4 0.0 0.3 0.0 0.5 81.1 0.0 13.8 0.4 0.1 1.3 23.3 0.0 0.8 2.7 0.0 0.7 0.4 1.6 2.4 0.5 1.0 0.1 0.5 0.2 7.5 0.8 TRPM7 "CHAK1, LTRPC7, TRP-PLIK" ENSG00000092439 "Transient receptor potential cation channel subfamily M member 7" Q96QT4 15 50552473-50686797 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins, Transporters, Voltage-gated ion channels" "Calcium transport, Ion transport, Necrosis, Transport" "Calcium channel, Ion channel, Kinase, Serine/threonine-protein kinase, Transferase" "Amyotrophic lateral sclerosis, Neurodegeneration, Parkinsonism" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "parathyroid gland: 108.9" "Cell type enhanced" "Detected in all" "Excitatory neurons: 122.2;Oligodendrocytes: 109.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "U-2197: 122.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA035522, HPA052173" Enhanced Approved "Vesicles,Plasma membrane,Cytosol" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 48: Parathyroid gland - membrane proteins" "Cluster 18: U-2197 - ECM organization" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Plasma membrane" "Vesicles, Cytosol" "HPA035522: , HPA052173: AB_2681749" "unprognostic (3.14e-2)" "unprognostic (1.86e-1)" "unprognostic (1.58e-1)" "unprognostic (1.42e-2)" "unprognostic (1.89e-1)" "unprognostic (1.60e-2)" "unprognostic (1.85e-2)" "unprognostic (2.59e-2)" "unprognostic (5.46e-3)" "unprognostic (2.64e-1)" "unprognostic (2.91e-1)" "unprognostic (1.59e-2)" "unprognostic (3.20e-2)" "unprognostic (2.08e-1)" "unprognostic (7.59e-2)" "unprognostic (9.45e-2)" "unprognostic (1.97e-1)" 11.5 9.6 4.3 13.3 6.5 21.4 13.6 15.4 6.7 10.3 29.3 13.8 14.4 12.7 14.6 8.6 9.4 11.1 15.5 4.8 3.5 22.9 25.3 11.6 16.6 4.9 3.9 16.4 12.2 108.9 5.3 13.3 5.9 10.9 14.4 10.5 10.9 10.6 7.8 16.6 13.1 11.4 3.2 12.2 13.6 9.9 6.4 15.5 17.3 9.1 14.4 11.4 8.1 10.4 21.4 21.0 17.2 19.1 48.5 36.2 20.9 26.4 36.7 16.5 21.6 29.1 11.6 46.4 12.7 30.8 42.5 35.1 23.3 19.5 23.4 26.0 13.7 37.1 31.5 15.4 44.0 38.8 27.6 33.9 22.4 18.8 35.0 24.0 13.5 28.8 42.6 34.5 30.4 33.7 25.1 18.8 13.0 29.4 12.8 27.2 23.7 22.7 23.0 49.9 14.2 18.1 18.2 28.7 35.8 30.1 18.0 41.6 20.7 26.1 12.4 122.4 30.8 23.3 54.9 44.0 28.4 77.5 24.8 1.8 1.3 1.6 2.5 1.3 2.9 2.2 1.8 1.7 1.5 2.3 1.6 1.9 1.7 2.4 1.4 1.9 2.0 0.8 4.3 6.5 15.4 6.7 4.8 3.5 4.9 3.9 5.9 3.2 6.4 10.4 23.9 19.2 31.3 73.1 36.4 31.6 17.2 11.0 44.9 21.9 18.8 11.9 25.9 21.5 8.2 12.9 12.5 23.0 38.4 17.0 3.9 11.7 33.3 21.6 27.1 19.7 18.5 29.6 122.2 12.7 9.4 26.1 37.8 23.1 17.7 26.0 14.6 43.9 14.6 21.9 92.7 19.5 6.1 22.4 19.8 26.0 26.4 26.5 19.6 66.5 24.2 8.5 29.9 80.9 109.1 15.5 13.9 20.3 33.2 24.9 23.4 11.0 19.3 22.6 13.1 30.0 22.0 23.1 23.6 25.7 24.2 16.3 34.5 22.2 20.4 11.1 TRPT1 MGC11134 ENSG00000149743 "TRNA phosphotransferase 1" Q86TN4 11 64223799-64226254 "Enzymes, Predicted intracellular proteins" "tRNA processing" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 173.8" "Cell type enhanced" "Detected in many" "Early spermatids: 147.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038705, HPA038706" Uncertain Approved Mitochondria NA NA "Cluster 22: NK-cells - Unknown function" "Cluster 80: Striated muscle - Unknown function" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 27: Mucus-secreting cells - Mucin production" Mitochondria "HPA038705: AB_2676161, HPA038706: AB_10671863" "unprognostic (2.50e-2)" "unprognostic (1.72e-1)" "unprognostic (1.33e-1)" "unprognostic (3.59e-2)" "unprognostic (7.20e-2)" "unprognostic (1.53e-1)" "unprognostic (5.84e-2)" "unprognostic (8.56e-2)" "unprognostic (1.18e-1)" "unprognostic (3.26e-3)" "unprognostic (1.12e-1)" "unprognostic (7.71e-2)" "unprognostic (7.38e-2)" "unprognostic (2.49e-1)" "unprognostic (3.28e-1)" "unprognostic (1.99e-1)" "unprognostic (4.58e-3)" 27.6 38.8 33.1 14.1 34.9 8.4 27.5 36.3 36.2 26.3 33.8 35.2 22.2 23.1 21.4 35.2 26.3 15.4 88.3 31.7 34.6 52.0 46.5 20.3 16.3 35.0 34.0 26.0 51.3 19.2 35.2 10.9 33.7 36.0 18.4 12.7 38.9 28.4 173.8 27.4 30.3 12.0 34.1 30.8 41.9 51.1 36.7 21.1 33.5 116.1 17.6 30.0 25.8 34.3 25.1 24.5 26.5 43.0 32.0 23.5 32.2 16.4 31.6 28.7 24.0 16.1 37.1 24.7 63.6 27.4 22.2 34.1 11.8 35.7 10.1 23.8 14.2 12.7 23.8 28.0 46.4 16.2 21.4 17.7 20.7 31.6 28.1 52.7 20.4 49.0 22.3 27.1 24.2 59.4 30.3 33.7 16.8 33.3 26.1 39.3 19.5 71.4 74.4 29.1 23.0 33.4 13.2 32.1 47.5 18.0 37.1 25.8 23.9 19.4 14.9 37.9 16.4 53.0 14.3 16.3 46.7 8.3 32.1 11.0 16.9 28.5 18.8 31.2 15.0 38.0 18.5 19.9 24.4 39.9 20.1 23.3 15.8 26.1 27.4 59.0 25.2 12.0 33.1 34.9 36.3 36.2 31.7 34.6 35.0 34.0 33.7 34.1 36.7 34.3 17.1 9.6 23.1 9.8 31.4 13.3 18.7 32.7 28.5 8.9 40.4 45.3 42.5 32.9 25.5 27.6 0.0 44.4 17.0 66.3 95.9 41.4 147.5 41.3 20.1 17.5 26.9 14.9 2.8 58.4 46.7 19.8 41.8 27.5 24.6 10.0 21.0 30.0 25.5 10.1 4.9 111.3 30.5 18.9 12.8 82.1 19.9 15.0 37.4 2.8 27.2 32.1 15.5 7.5 6.8 46.6 60.5 17.0 47.1 24.0 92.0 82.9 48.2 11.6 6.6 22.4 29.3 59.6 13.4 42.8 18.5 36.0 21.8 20.2 40.3 22.6 TSSK1B "FKSG81, SPOGA4, STK22D, TSSK1" ENSG00000212122 "Testis specific serine kinase 1B" Q9BXA7 5 113432553-113434989 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Differentiation, Spermatogenesis" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 224 "testis: 53.6" "Group enriched" "Detected in some" 108 "Early spermatids: 490.9;Late spermatids: 1056.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA027827 Enhanced NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 25: Spermatids - Spermatogenesis" "HPA027827: AB_10603138" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 53.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 490.9 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1056.0 4.7 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.1 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 TSSK2 "FLJ38613, SPOGA2, STK22B" ENSG00000206203 "Testis specific serine kinase 2" Q96PF2 22 19131308-19132622 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Differentiation, Spermatogenesis" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 231 "testis: 135.9" "Group enriched" "Detected in some" 94 "Early spermatids: 1657.2;Late spermatids: 3184.4" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in single" "HaCaT: 1.0" "Not detected" "Not detected" "Low region specificity" "Detected in single" NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 17: WM-115 - Nervous system development" "Cluster 25: Spermatids - Spermatogenesis" 0.0 0.0 0.1 0.2 0.1 0.0 0.1 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.1 0.0 0.0 0.0 0.0 0.3 0.1 0.2 0.5 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.1 0.0 0.0 135.9 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.4 0.0 0.1 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.5 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.1 0.0 0.3 0.0 0.1 0.1 0.0 0.2 0.0 0.1 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.2 0.7 0.4 0.0 0.1 0.1 0.6 0.2 0.0 0.1 0.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.3 0.2 0.2 0.1 0.3 0.1 0.2 0.1 0.2 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1657.2 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3184.4 18.3 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.4 0.0 0.0 0.0 0.0 0.0 0.0 6.6 0.0 0.0 25.7 12.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 TSSK3 "SPOGA3, STK22C" ENSG00000162526 "Testis specific serine kinase 3" Q96PN8 1 32351521-32364312 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Differentiation, Spermatogenesis" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "bone marrow: 12.7;testis: 34.0" "Group enriched" "Detected in some" 67 "Early spermatids: 335.4;Late spermatids: 1251.0" "Not detected" "Not detected" "Region enriched" "Detected in single" 4 "cerebellum: 2.2" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "HeLa: 14.1" "Not detected" "Not detected" "Not detected" "Not detected" HPA037516 Approved "Nucleoplasm,Nucleoli,Nuclear bodies" NA NA "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 23: Testis - Cell cycle regulation" "Cluster 20: HeLa - Mitochondria" "Cluster 25: Spermatids - Spermatogenesis" "Nucleoplasm, Nucleoli" "Nuclear bodies" "HPA037516: AB_2675517" "unprognostic (5.71e-2)" "unprognostic (1.42e-1)" "unprognostic (2.32e-1)" "unprognostic (1.37e-1)" "unprognostic (7.69e-2)" "unprognostic (2.02e-4)" "unprognostic (2.06e-1)" "unprognostic (1.98e-3)" "unprognostic (2.05e-2)" "unprognostic (1.11e-1)" "unprognostic (1.46e-2)" "unprognostic (9.20e-2)" "unprognostic (1.02e-3)" "unprognostic (1.11e-2)" "unprognostic (1.51e-1)" "unprognostic (1.88e-1)" "unprognostic (2.68e-3)" 2.3 2.7 0.1 2.5 0.2 12.7 2.0 2.2 0.4 2.9 0.3 2.1 3.4 2.3 0.0 1.3 2.7 1.8 1.5 0.1 0.0 1.9 2.7 2.7 3.8 0.5 0.0 3.0 2.1 0.0 1.7 0.7 0.2 2.1 0.0 4.3 2.4 0.0 3.0 4.7 4.0 0.1 0.0 4.3 2.2 34.0 0.2 0.0 2.3 0.0 0.0 1.7 2.3 0.5 2.4 2.8 6.0 3.6 0.0 0.8 5.2 0.6 0.9 0.0 0.0 0.5 1.3 1.4 0.8 0.0 1.0 3.5 0.0 0.0 0.0 3.6 6.8 2.8 14.1 4.3 3.3 1.3 3.2 0.1 0.7 0.0 1.0 6.7 0.0 4.5 3.5 5.5 0.0 0.7 1.5 1.5 1.1 0.5 1.6 2.1 1.6 4.7 0.0 2.4 1.7 3.8 0.8 3.0 3.9 4.5 1.8 2.4 2.4 2.1 2.9 3.0 2.4 7.6 3.3 1.9 3.5 4.3 0.7 0.0 0.0 0.0 0.2 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.2 2.2 0.4 0.1 0.0 0.5 0.0 0.2 0.0 0.2 0.5 0.4 0.0 0.5 0.7 0.3 0.1 0.4 0.3 0.0 0.2 0.2 0.3 0.3 0.0 0.1 0.0 0.0 0.2 0.2 0.1 0.0 0.3 335.4 0.4 0.6 0.5 0.0 0.0 0.0 0.7 0.1 0.3 0.0 0.5 0.0 1.4 0.7 0.1 0.1 0.0 0.0 0.5 0.0 0.0 0.0 1251.0 9.3 0.3 0.0 0.0 0.5 0.6 0.0 0.0 0.1 0.3 0.1 9.4 0.0 0.2 0.7 0.8 0.8 1.2 6.6 0.2 0.2 11.7 3.7 0.0 0.0 0.3 0.2 0.5 0.3 0.3 TSSK4 "C14orf20, STK22E" ENSG00000139908 "Testis specific serine kinase 4" Q6SA08 14 24205696-24208362 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Differentiation, Spermatogenesis" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 9 "testis: 38.1" "Cell type enriched" "Detected in some" 9 "Early spermatids: 253.7" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA060660, HPA077103" Approved Approved "Cell Junctions" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 83: Testis - Spermatogenesis" "Cluster 20: HeLa - Mitochondria" "Cluster 23: Spermatids - Flagellum & Golgi organization" "Cell Junctions" "HPA060660: AB_2684339, HPA077103: AB_2732332" "unprognostic (1.95e-1)" "unprognostic (4.30e-2)" "unprognostic (1.52e-1)" "unprognostic (5.69e-2)" "unprognostic (2.36e-1)" "unprognostic (3.38e-5)" "unprognostic (1.06e-1)" "unprognostic (6.25e-3)" "unprognostic (1.64e-1)" "unprognostic (3.39e-1)" "unprognostic (7.03e-3)" "unprognostic (1.27e-3)" "unprognostic (3.42e-1)" "unprognostic (4.30e-2)" "unprognostic (6.28e-2)" "unprognostic (8.98e-2)" "unprognostic (7.26e-2)" 1.0 1.1 0.7 2.0 0.4 3.4 1.0 1.0 0.3 1.4 0.0 1.4 1.6 1.1 0.3 1.3 1.2 1.6 0.7 0.6 0.1 0.8 0.6 1.0 2.7 0.3 0.3 1.1 1.5 0.0 0.9 0.4 0.3 0.9 0.0 3.1 1.5 0.0 1.3 4.2 1.7 0.0 0.2 1.7 1.2 38.1 0.3 0.0 1.4 0.0 0.0 1.1 1.1 0.3 0.6 2.3 2.2 0.8 0.0 0.0 2.4 0.9 0.0 0.0 0.0 1.3 2.2 1.8 0.5 0.1 0.4 2.1 0.0 0.1 0.0 0.9 1.7 2.0 3.4 1.7 0.0 1.0 2.1 0.0 0.0 0.0 0.3 1.9 0.0 2.1 0.8 1.2 0.0 2.2 2.1 1.1 0.4 0.5 1.8 1.8 0.8 1.5 0.0 3.0 1.2 1.2 1.7 1.4 0.4 0.9 1.0 1.0 0.9 1.6 1.0 2.1 0.7 2.3 3.0 2.6 0.5 1.6 0.5 0.0 0.2 0.4 0.4 0.2 0.1 0.3 0.3 0.3 0.1 0.3 0.3 0.3 0.3 0.5 0.1 0.3 0.1 0.1 0.7 0.4 1.0 0.3 0.6 0.1 0.3 0.3 0.3 0.2 0.3 0.3 0.0 0.0 0.5 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 253.7 0.3 0.1 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 26.5 1.2 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.2 0.1 0.1 0.3 0.1 0.8 0.0 0.0 0.2 0.1 6.8 0.8 0.0 0.0 0.1 0.1 0.1 0.0 0.0 TSSK6 "CT72, FLJ24002, SSTK" ENSG00000178093 "Testis specific serine kinase 6" Q9BXA6 19 19512418-19515548 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Differentiation, Spermatogenesis" "Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 102 "testis: 167.6" "Cell type enriched" "Detected in some" 5 "Late spermatids: 8709.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "BEWO: 3.4;CACO-2: 1.7" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 83: Testis - Spermatogenesis" "Cluster 28: BEWO - Transcription regulation" "Cluster 25: Spermatids - Spermatogenesis" "unprognostic (2.12e-1)" "unprognostic (7.89e-2)" "unprognostic (7.26e-2)" "unprognostic (6.64e-2)" "unprognostic (3.39e-1)" "unprognostic (7.20e-5)" "unprognostic (3.38e-1)" "unprognostic (5.51e-3)" "unprognostic (5.17e-2)" "unprognostic (1.46e-1)" "unprognostic (3.98e-4)" "unprognostic (2.28e-2)" "unprognostic (5.34e-3)" "unprognostic (2.74e-3)" "unprognostic (2.78e-2)" "unprognostic (1.52e-3)" "unprognostic (9.89e-2)" 0.6 0.7 0.4 0.0 0.6 0.1 0.7 0.5 0.5 0.4 0.1 0.7 0.5 0.8 0.0 0.7 0.6 0.0 0.3 0.3 0.2 0.9 1.2 0.4 0.3 0.7 0.6 0.5 1.0 0.0 0.7 0.0 0.7 0.9 0.0 0.0 0.6 0.0 0.3 1.6 1.0 0.0 0.6 1.2 0.9 167.6 0.5 0.1 0.9 0.0 0.1 0.6 0.6 1.0 0.0 0.6 0.0 0.0 0.0 0.1 3.4 0.1 0.2 0.0 0.1 1.7 0.0 0.7 0.1 0.0 0.0 0.4 0.1 0.6 0.0 0.5 0.0 0.4 0.4 0.0 0.4 0.4 0.7 0.3 0.1 0.2 0.5 0.0 0.1 0.0 0.2 0.0 0.0 0.2 0.3 0.7 0.3 0.0 0.0 0.6 0.0 0.5 0.0 0.2 0.2 0.4 0.0 0.0 0.0 0.0 0.6 0.5 0.0 0.5 0.2 0.9 0.2 0.8 0.6 0.0 0.7 0.4 0.9 0.0 0.1 0.3 0.1 0.0 0.1 0.7 0.0 0.2 0.0 0.1 0.8 0.4 0.1 0.0 0.0 0.2 0.1 0.2 0.4 0.6 0.5 0.5 0.3 0.2 0.7 0.6 0.7 0.6 0.5 1.0 0.2 0.0 0.0 0.0 0.0 0.4 0.2 0.1 0.0 0.0 0.3 0.1 1.7 1.5 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.2 1462.5 0.5 0.4 2.7 0.0 0.0 0.0 0.2 0.1 0.1 0.0 0.8 0.0 0.1 0.7 0.5 0.1 0.0 0.0 0.0 2.0 0.8 0.5 8709.8 47.8 2.2 1.8 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 57.2 0.1 0.1 0.5 0.2 0.3 0.0 19.7 1.1 0.3 57.7 25.7 0.0 0.1 0.1 0.2 0.0 0.1 0.1 TST RDS ENSG00000128311 "Thiosulfate sulfurtransferase" Q16762 22 37010859-37020183 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 561.2" "Cell type enhanced" "Detected in many" "Distal enterocytes: 565.8;Hepatocytes: 414.9;Paneth cells: 463.4;Proximal enterocytes: 278.5;Proximal tubular cells: 254.5;Undifferentiated cells: 217.4" "Cancer enhanced" "Detected in all" "liver cancer: 177.0" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "myeloid DC: 25.0" "Group enriched" "Detected in all" 6 "dendritic cells: 25.0;granulocytes: 21.8;monocytes: 17.7" "Cell line enhanced" "Detected in many" "OE19: 264.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003044, HPA003643, CAB009546" Enhanced Supported Mitochondria NA NA 560000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 85: Liver - Metabolism" "Cluster 21: OE19 - Mitochondria" "Cluster 53: Intestinal epithelial cells - Unknown function" Mitochondria "CAB009546: AB_2211220, HPA003044: AB_1858417, HPA003643: AB_1080411" "unprognostic (3.09e-2)" "unprognostic (2.70e-1)" "unprognostic (2.07e-1)" "unprognostic (1.21e-2)" "unprognostic (2.36e-2)" "unprognostic (1.11e-1)" "unprognostic (2.49e-2)" "unprognostic (2.38e-2)" "unprognostic (2.32e-1)" "unprognostic (7.96e-3)" "unprognostic (4.38e-2)" "unprognostic (1.78e-1)" "prognostic favorable (7.59e-6)" "unprognostic (6.08e-3)" "unprognostic (3.46e-1)" "unprognostic (1.16e-1)" "prognostic favorable (1.04e-4)" 51.4 154.1 31.3 20.9 40.5 27.1 37.3 38.2 36.0 34.1 31.3 190.7 147.7 18.9 2.9 96.7 25.7 75.9 69.9 29.1 33.1 100.8 561.2 22.7 8.1 34.4 35.2 26.9 63.6 9.4 12.4 7.9 34.4 26.4 80.3 1.3 39.8 18.2 52.9 33.8 114.2 13.2 35.4 16.9 88.4 8.1 35.8 4.3 17.1 34.9 16.2 30.0 56.7 39.0 42.6 86.1 10.8 36.8 25.9 10.6 21.4 23.0 18.6 12.6 18.3 25.4 25.7 11.1 18.8 17.0 11.9 35.1 7.9 22.3 2.7 33.6 50.0 11.5 15.5 49.7 64.9 16.4 26.4 20.1 23.9 9.1 7.6 17.5 31.1 5.9 14.2 18.2 6.0 90.8 0.5 49.9 18.7 264.4 39.3 37.0 11.7 19.7 35.9 36.7 6.4 17.1 24.2 41.4 31.7 10.2 43.4 39.3 25.1 14.0 27.2 24.2 7.4 14.0 15.4 3.4 5.3 46.4 8.5 10.9 17.7 8.0 0.8 4.7 1.7 2.8 0.8 0.6 25.0 1.7 0.4 0.2 21.8 3.7 1.5 1.7 2.1 8.1 31.3 40.5 38.2 36.0 29.1 33.1 34.4 35.2 34.4 35.4 35.8 39.0 13.9 28.9 74.8 10.1 7.8 1.3 9.5 20.4 12.0 1.3 32.7 16.6 39.2 170.1 23.7 20.2 0.0 11.6 2.5 565.8 46.9 45.3 1.9 53.3 30.2 13.4 34.3 35.3 0.3 44.0 6.4 14.6 126.9 74.3 14.0 60.9 39.3 414.9 15.1 1.7 0.5 162.8 8.2 28.9 6.8 3.5 13.1 23.2 1.8 1.0 18.6 27.3 3.1 3.5 7.4 36.8 463.4 7.9 24.5 10.5 278.5 254.5 19.2 0.8 0.0 10.7 11.5 2.4 0.5 39.8 2.4 11.4 5.0 57.5 217.4 17.3 TTBK1 KIAA1855 ENSG00000146216 "Tau tubulin kinase 1" Q5TCY1 6 43243481-43288258 "Enzymes, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "brain: 20.7;pituitary gland: 9.2" "Cell type enhanced" "Detected in some" "Astrocytes: 10.7;Bipolar cells: 6.6;Excitatory neurons: 12.1;Inhibitory neurons: 13.0;Oligodendrocyte precursor cells: 12.1;Oligodendrocytes: 12.4" "Group enriched" "Detected in some" 4 "glioma: 3.0;liver cancer: 0.8" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 8 "SCLC-21H: 20.3;SH-SY5Y: 7.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA031735, HPA031736" Enhanced Supported Nucleoplasm,Cytosol NA NA "Cluster 10: Brain - Neuronal signaling" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Cytosol Nucleoplasm "HPA031735: AB_2674019, HPA031736: AB_10670294" "unprognostic (1.68e-1)" "unprognostic (7.88e-3)" "unprognostic (7.01e-2)" "unprognostic (1.62e-3)" "unprognostic (2.18e-1)" "unprognostic (2.24e-4)" "unprognostic (2.46e-3)" "unprognostic (3.01e-2)" "unprognostic (3.09e-1)" "unprognostic (1.85e-1)" "unprognostic (3.01e-2)" "unprognostic (2.12e-4)" "unprognostic (7.42e-2)" "unprognostic (3.68e-1)" "unprognostic (1.32e-1)" "unprognostic (2.64e-3)" "unprognostic (3.04e-4)" 0.0 1.3 11.8 0.2 10.6 0.0 0.0 3.8 20.7 0.0 0.0 0.2 1.7 0.0 0.0 0.0 0.0 0.2 0.1 12.0 1.1 0.4 1.9 0.0 0.1 5.0 2.2 0.0 0.2 0.3 9.2 0.0 3.5 0.1 0.1 3.0 0.0 0.1 0.0 0.0 2.8 0.0 0.5 0.1 0.1 0.9 6.0 0.0 0.0 0.0 0.2 0.0 0.0 11.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 1.1 0.0 0.3 0.0 0.0 0.7 0.0 0.2 0.1 0.7 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.0 0.0 0.3 0.6 0.0 0.1 0.0 0.0 0.0 0.0 20.3 7.8 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.5 1.7 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.8 10.6 3.8 20.7 12.0 1.1 5.0 2.2 3.5 0.5 6.0 11.0 0.0 0.0 0.0 10.7 0.0 0.0 0.1 0.0 0.0 6.6 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.2 0.1 0.1 0.1 0.0 0.0 12.1 0.2 0.0 0.1 0.0 0.0 0.0 2.2 0.4 2.5 0.1 5.0 13.0 0.2 0.0 0.0 0.4 0.5 0.0 0.0 0.0 2.8 0.0 1.4 0.0 12.1 12.4 0.0 1.1 0.0 0.0 0.0 3.8 3.5 0.0 0.5 0.0 0.0 0.1 0.3 0.5 0.0 0.0 0.0 0.1 0.0 0.6 0.0 TTBK2 "KIAA0847, SCA11" ENSG00000128881 "Tau tubulin kinase 2" Q6IQ55 15 42738730-42920809 "Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted intracellular proteins" "Cilium biogenesis/degradation" "Kinase, Serine/threonine-protein kinase, Transferase" "Neurodegeneration, Spinocerebellar ataxia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "testis: 33.4" "Cell type enhanced" "Detected in many" "Excitatory neurons: 153.8;Inhibitory neurons: 185.1;Late spermatids: 146.2;Oligodendrocytes: 125.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA018113, HPA049866" Approved Uncertain "Intermediate filaments" NA NA "Cluster 15: NK-cells - Transcription" "Cluster 21: Non-specific - Transcription" "Cluster 44: HDLM-2 - Immune response" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Intermediate filaments" "HPA018113: AB_1858421, HPA049866: AB_2680923" "unprognostic (2.15e-1)" "unprognostic (1.67e-1)" "unprognostic (1.08e-1)" "unprognostic (6.30e-2)" "unprognostic (7.73e-2)" "unprognostic (4.26e-1)" "unprognostic (6.64e-2)" "unprognostic (5.11e-2)" "unprognostic (1.32e-1)" "unprognostic (2.43e-2)" "unprognostic (2.78e-2)" "unprognostic (8.62e-2)" "unprognostic (3.46e-2)" "unprognostic (7.29e-2)" "unprognostic (3.63e-2)" "unprognostic (2.18e-1)" "unprognostic (1.38e-1)" 5.3 4.2 7.7 3.0 9.9 5.2 4.4 11.3 20.0 6.0 2.1 6.7 1.6 5.3 3.9 2.6 5.5 3.7 7.2 6.9 13.9 3.4 3.1 4.8 3.4 17.4 9.1 6.4 2.5 4.6 5.6 4.0 18.9 4.7 3.0 17.7 3.2 3.8 10.4 3.1 3.9 5.0 6.3 4.3 3.4 33.4 16.9 5.2 3.8 6.3 3.1 5.3 4.7 13.8 5.7 3.8 8.4 4.2 6.5 6.6 1.8 4.6 7.4 4.5 6.9 4.3 1.3 3.3 6.1 4.7 9.2 3.9 8.1 6.7 6.8 13.0 3.6 4.8 6.9 1.6 5.0 6.7 7.8 4.7 6.5 3.9 21.1 9.9 5.2 5.1 7.0 4.9 4.5 0.9 4.1 4.3 2.3 1.7 3.8 7.2 9.1 1.7 5.8 4.0 6.6 6.5 12.6 0.9 2.5 5.8 2.6 8.7 5.8 5.1 4.7 5.7 6.0 7.1 11.3 5.5 3.9 5.8 3.0 0.1 0.5 0.2 0.2 0.3 0.5 0.3 0.2 0.2 0.1 0.3 0.3 0.2 0.2 0.4 0.2 0.2 0.1 0.1 7.7 9.9 11.3 20.0 6.9 13.9 17.4 9.1 18.9 6.3 16.9 13.8 16.2 6.4 11.8 75.7 11.5 10.7 12.1 11.8 26.2 36.3 9.6 7.6 17.6 12.8 10.0 9.2 37.5 4.1 9.1 3.9 0.0 5.7 80.5 24.9 11.7 17.0 14.3 17.4 153.8 4.3 3.2 15.5 4.6 4.6 19.0 16.2 17.5 9.8 7.4 45.4 185.1 5.1 2.0 16.0 25.9 146.2 16.8 16.4 12.4 69.3 16.9 16.5 6.2 97.5 125.6 7.5 2.6 20.3 6.6 12.4 5.5 5.5 40.5 39.4 13.1 24.6 16.3 34.5 10.1 12.5 9.2 3.1 13.4 11.3 5.3 7.4 TTC3 "DCRR1, RNF105, TPRD, TPRDI, TPRDII, TPRDIII" ENSG00000182670 "Tetratricopeptide repeat domain 3" P53804 21 37073226-37203112 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016810, HPA023964, HPA036304" Uncertain Approved Nucleoplasm,Nucleoli,Cytosol No No "Cluster 29: Plasmacytoid DCs - Unknown function" "Cluster 51: Non-specific - Unknown function" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis" "Nucleoplasm, Nucleoli" Cytosol "HPA016810: AB_1858434, HPA023964: AB_1858435, HPA036304: AB_2675049" "unprognostic (3.90e-2)" "unprognostic (1.65e-1)" "unprognostic (1.19e-1)" "unprognostic (1.22e-1)" "unprognostic (1.53e-1)" "unprognostic (1.37e-2)" "unprognostic (8.52e-2)" "unprognostic (9.29e-2)" "unprognostic (8.71e-2)" "unprognostic (1.61e-1)" "unprognostic (2.05e-2)" "unprognostic (1.99e-1)" "unprognostic (9.10e-2)" "unprognostic (1.02e-1)" "unprognostic (1.60e-1)" "unprognostic (1.39e-1)" "unprognostic (6.74e-2)" 45.8 29.3 28.1 27.1 25.0 26.4 43.1 36.3 35.3 59.3 45.7 34.6 24.7 38.9 58.6 27.9 34.9 35.4 28.0 38.9 15.5 37.7 31.7 24.4 29.4 10.0 11.1 60.6 42.9 39.1 35.6 29.0 11.8 51.2 36.3 63.0 50.0 41.4 27.7 30.7 30.3 34.6 6.7 27.3 40.9 27.4 15.3 38.0 64.8 30.6 29.2 30.6 9.4 21.4 72.9 25.4 115.3 22.2 108.9 156.8 40.0 77.5 96.0 34.2 46.1 34.0 35.8 62.3 26.6 130.9 32.1 23.3 35.3 47.9 48.2 66.3 25.0 125.6 38.0 44.1 39.6 70.9 39.1 81.9 28.8 35.0 31.0 68.8 51.6 54.1 77.3 71.1 65.2 56.0 69.4 18.8 33.3 48.0 42.6 91.6 55.3 33.2 39.4 55.3 87.7 67.6 97.2 55.2 49.1 26.5 62.2 27.3 68.3 49.2 19.5 61.2 30.4 71.1 55.1 60.6 80.7 69.9 37.9 4.8 6.2 6.8 11.5 6.4 17.1 13.0 13.3 15.8 10.8 15.1 23.2 14.4 1.0 12.8 8.6 17.3 10.0 4.8 28.1 25.0 36.3 35.3 38.9 15.5 10.0 11.1 11.8 6.7 15.3 21.4 78.3 125.0 142.7 161.3 144.8 65.9 94.8 102.7 86.0 347.7 175.8 140.1 134.7 68.6 118.2 75.4 227.2 50.1 129.5 67.8 166.3 91.1 192.7 115.0 217.4 78.9 190.2 65.4 424.5 75.3 93.5 171.0 131.5 132.0 64.6 256.8 99.6 94.4 61.4 329.7 396.0 163.1 99.7 95.2 83.7 192.4 210.0 86.8 211.7 111.5 87.4 196.5 93.7 321.7 261.9 73.3 96.5 261.1 167.6 121.4 72.8 96.1 108.6 233.9 52.6 245.8 127.9 400.0 258.4 91.7 62.8 52.7 109.7 204.1 148.1 103.9 TTK "CT96, MPH1, MPS1, MPS1L1" ENSG00000112742 "TTK protein kinase" P33981 6 80003887-80042527 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "bone marrow: 25.3;lymphoid tissue: 46.6;testis: 34.3" "Cell type enhanced" "Detected in many" "Early spermatids: 43.3;Erythroid cells: 23.1;Late spermatids: 21.4;Spermatocytes: 130.5;Spermatogonia: 33.0" "Low cancer specificity" "Detected in many" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "T-reg: 1.2" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in many" "Not detected" "Not detected" "Low region specificity" "Detected in single" "CAB010166, CAB013229" Enhanced Approved Nucleoli,Cytosol NA Yes "Cluster 4: T-regs - Cell cycle regulation" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 66: Spermatocytes - Spermatogenesis" "Nucleoli, Cytosol" "CAB010166: AB_632567, CAB013229: AB_2533230" "unprognostic (4.27e-2)" "unprognostic (8.71e-2)" "unprognostic (1.04e-2)" "prognostic unfavorable (1.44e-5)" "unprognostic (7.97e-2)" "unprognostic (4.78e-2)" "prognostic unfavorable (3.84e-10)" "unprognostic (1.56e-3)" "unprognostic (7.95e-2)" "unprognostic (2.02e-3)" "prognostic unfavorable (2.54e-4)" "unprognostic (1.54e-1)" "unprognostic (0.00e+0)" "unprognostic (3.51e-2)" "unprognostic (1.06e-1)" "unprognostic (1.46e-1)" "unprognostic (1.66e-1)" 0.7 0.8 0.0 4.2 0.1 25.3 2.2 0.1 0.3 0.7 0.0 4.8 4.0 1.0 0.1 4.8 0.6 0.5 0.1 0.1 0.1 0.2 0.5 0.8 8.1 0.2 0.1 0.2 0.2 0.3 0.0 3.9 0.2 0.8 5.9 1.8 0.7 0.1 0.0 3.6 4.1 1.7 0.1 1.4 3.3 34.3 0.2 46.6 0.4 0.1 9.0 1.2 1.4 0.2 39.9 23.4 68.2 56.4 3.1 9.5 38.5 44.9 27.4 64.2 77.8 32.1 29.6 58.5 34.1 19.5 66.9 50.0 60.7 27.6 88.6 53.4 49.3 54.1 29.4 26.5 0.2 64.4 33.9 1.2 2.8 45.0 28.6 9.6 36.9 80.6 60.2 58.5 55.2 29.5 37.0 46.4 40.4 35.4 27.9 32.7 124.4 24.4 16.3 25.2 46.8 27.4 26.6 28.3 16.3 36.6 26.6 48.3 15.4 28.8 28.5 18.8 72.9 13.1 47.1 32.4 10.3 58.9 25.1 0.0 0.0 0.3 0.1 0.0 0.1 0.2 0.2 0.4 0.0 0.7 0.0 0.1 0.0 0.3 0.0 0.0 1.2 0.2 0.0 0.1 0.1 0.3 0.1 0.1 0.2 0.1 0.2 0.1 0.2 0.2 0.3 3.2 1.1 0.0 1.4 1.3 0.6 2.6 0.0 0.2 0.9 0.5 0.6 0.0 2.3 0.0 2.1 9.8 0.8 2.2 3.9 0.4 43.3 3.1 1.6 1.1 1.8 23.1 0.2 0.2 15.0 2.1 2.6 2.3 1.3 13.9 0.7 0.2 6.5 0.0 0.2 3.0 4.1 2.6 1.2 21.4 0.9 1.9 0.0 0.0 5.2 0.2 1.0 0.0 0.1 0.6 0.2 0.7 5.1 0.4 0.3 0.1 3.0 1.6 6.6 0.1 1.7 130.5 33.0 8.5 0.3 3.7 1.1 0.5 5.6 1.6 TTN "CMD1G, CMH9, CMPD4, FLJ32040, LGMD2J, MYLK5, TMD" ENSG00000155657 Titin Q8WZ42 2 178525989-178830802 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Calmodulin-binding, Kinase, Serine/threonine-protein kinase, Transferase" "Cardiomyopathy, Disease variant, Limb-girdle muscular dystrophy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 167.2;skeletal muscle: 920.6;tongue: 369.5" "Cell type enriched" "Detected in many" 16 "Cardiomyocytes: 24394.9" "Cancer enriched" "Detected in single" 4 "head and neck cancer: 1.3" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in some" "RH-30: 1.9" "Not detected" "Not detected" "HPA007042, CAB022682, HPA030048" Enhanced NA NA 16000000 "Cluster 15: NK-cells - Transcription" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 54: Cardiomyocytes - Muscle contraction" "CAB022682: , HPA007042: AB_1080292, HPA030048: AB_2732451" "unprognostic (1.00e-2)" "unprognostic (3.92e-1)" "unprognostic (1.77e-1)" "unprognostic (7.11e-2)" "unprognostic (3.71e-2)" "unprognostic (1.49e-2)" "unprognostic (6.62e-2)" "unprognostic (1.84e-1)" "unprognostic (2.49e-2)" "unprognostic (1.86e-1)" "unprognostic (2.79e-1)" "unprognostic (2.65e-1)" "unprognostic (3.49e-4)" "unprognostic (1.99e-1)" "unprognostic (1.15e-1)" "unprognostic (1.09e-1)" "unprognostic (1.34e-2)" 0.6 0.4 2.7 0.5 2.4 4.3 0.5 2.8 4.9 0.3 0.0 0.4 0.4 0.4 0.2 2.7 0.3 0.7 167.2 1.9 3.4 0.2 0.3 1.2 1.4 11.2 4.4 0.7 1.7 0.0 0.8 0.5 6.6 2.7 0.0 1.9 7.0 0.0 920.6 0.8 0.6 0.0 3.2 0.7 0.4 1.6 4.8 0.7 0.6 369.5 0.4 0.2 0.3 5.3 0.3 0.1 0.7 0.4 0.0 0.0 1.4 0.2 0.0 0.0 0.0 0.7 0.1 1.0 0.2 0.0 0.7 0.7 0.0 0.0 0.0 1.0 0.8 1.5 1.3 0.4 0.0 0.1 0.3 0.9 0.0 0.0 0.0 0.7 0.6 0.7 0.9 0.5 0.1 0.2 0.7 1.0 0.2 0.1 0.7 0.5 1.9 0.6 0.0 0.2 0.4 0.7 0.1 0.5 0.0 0.6 0.3 1.0 0.7 0.0 0.0 0.3 0.2 1.4 0.2 1.4 0.0 0.5 0.3 1.8 0.2 0.5 0.4 0.2 0.1 6.1 0.9 0.7 0.1 5.7 2.0 2.6 1.0 3.6 0.2 0.2 6.0 0.1 2.7 2.4 2.8 4.9 1.9 3.4 11.2 4.4 6.6 3.2 4.8 5.3 10.9 16.0 173.4 43.8 32.1 0.9 1.6 0.0 2.8 102.7 1.7 0.5 24394.9 30.0 6.2 0.0 20.9 0.7 6.8 0.1 1.9 14.1 43.2 3.4 6.8 99.1 4.2 3.0 25.1 28.3 0.3 502.5 3.6 7.2 10.1 0.7 2.5 0.6 0.3 16.8 31.3 0.1 0.0 0.8 0.8 6.4 1.2 26.2 0.0 25.3 0.6 12.0 2.1 11.6 4.9 0.5 0.1 4.5 10.6 0.2 0.3 0.4 2.9 27.8 0.0 1466.9 104.7 9.3 1.5 2.3 0.1 0.4 24.3 2.8 0.5 0.1 TUT1 "FLJ21850, FLJ22267, FLJ22347, PAPD2, RBM21, TENT1, TUTase" ENSG00000149016 "Terminal uridylyl transferase 1, U6 snRNA-specific" Q9H6E5 11 62575045-62591637 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "mRNA processing" "Nucleotidyltransferase, RNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Adipocytes: 32.5;Early spermatids: 34.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA069055, HPA071838" Supported Nucleoplasm,Cytosol NA NA "Cluster 10: Basophils - Unknown function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 25: RPMI-8226 - Immune response" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" Nucleoplasm Cytosol "HPA069055: AB_2686075, HPA071838: AB_2686456" "unprognostic (3.81e-2)" "unprognostic (3.54e-2)" "prognostic unfavorable (9.51e-4)" "unprognostic (2.43e-1)" "unprognostic (1.01e-1)" "unprognostic (7.59e-2)" "unprognostic (1.83e-1)" "unprognostic (2.59e-2)" "unprognostic (1.83e-1)" "unprognostic (5.79e-3)" "unprognostic (1.59e-2)" "unprognostic (2.71e-1)" "unprognostic (7.20e-3)" "unprognostic (1.03e-2)" "unprognostic (4.41e-1)" "unprognostic (1.35e-1)" "unprognostic (3.97e-3)" 10.5 10.7 9.1 7.4 10.1 6.0 11.8 9.1 9.9 10.4 8.1 8.9 8.8 9.9 5.8 9.3 11.2 6.1 9.5 8.8 8.6 10.7 22.2 8.3 11.8 10.5 9.3 11.2 19.4 7.6 10.6 6.2 10.1 12.7 4.0 5.4 11.7 7.3 20.4 12.8 10.2 4.6 9.4 12.7 12.6 13.6 9.8 10.2 12.3 7.6 7.9 10.4 9.2 12.0 12.5 16.0 10.7 15.4 12.6 7.3 14.0 12.7 8.3 11.2 9.7 14.0 24.9 19.5 30.1 6.6 14.3 23.7 19.8 15.9 5.7 15.1 10.5 20.3 15.8 14.1 14.3 14.8 9.3 10.3 16.6 13.7 21.1 10.5 10.8 26.2 32.1 20.7 9.6 28.8 21.1 33.3 12.4 8.4 19.1 23.7 16.6 50.9 10.6 6.9 18.2 24.6 10.4 19.6 17.5 8.9 27.2 14.2 10.1 12.9 11.3 15.2 10.1 36.1 32.9 24.6 14.8 11.5 10.7 6.0 5.9 7.0 9.9 7.2 13.7 9.2 9.5 8.1 7.9 11.6 14.3 11.7 3.5 11.0 5.6 9.3 9.2 7.7 9.1 10.1 9.1 9.9 8.8 8.6 10.5 9.3 10.1 9.4 9.8 12.0 32.5 0.0 6.7 7.5 7.5 2.7 5.2 7.2 4.0 8.4 5.9 5.2 4.2 18.6 7.1 11.0 6.2 12.8 6.0 4.4 5.9 8.5 34.3 5.7 3.1 15.0 7.2 3.2 3.9 7.4 7.8 5.1 7.7 4.1 2.5 5.5 18.2 17.8 5.9 1.7 4.6 9.1 6.1 5.0 2.2 16.4 7.2 4.3 10.6 1.0 4.0 9.8 14.4 4.0 5.4 5.6 3.6 3.4 4.9 7.1 8.4 7.1 13.1 8.4 0.0 4.1 4.1 10.0 16.3 3.1 2.3 14.0 5.6 5.6 7.0 3.1 TUT4 "KIAA0191, PAPD3, TENT3A, ZCCHC11" ENSG00000134744 "Terminal uridylyl transferase 4" Q5TAX3 1 52408282-52553487 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "RNA-mediated gene silencing" "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Adipocytes: 52.2;Cytotrophoblasts: 53.6;dendritic cells: 64.9;Endometrial ciliated cells: 59.5;Endometrial stromal cells: 96.1;Granulosa cells: 70.7;Theca cells: 57.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027412, HPA027973" Supported Supported Nucleoli,Cytosol NA NA "Cluster 6: Non-specific - Transcription" "Cluster 77: Retina - Visual perception" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 7: Non-specific - Mitochondria" Cytosol Nucleoli "HPA027412: AB_1852281, HPA027973: AB_10603242" "unprognostic (2.74e-2)" "unprognostic (1.67e-2)" "unprognostic (1.19e-2)" "unprognostic (3.48e-2)" "unprognostic (1.36e-2)" "unprognostic (1.85e-3)" "prognostic unfavorable (9.00e-4)" "unprognostic (2.64e-1)" "unprognostic (5.05e-2)" "unprognostic (3.84e-1)" "unprognostic (6.57e-3)" "unprognostic (3.11e-2)" "unprognostic (5.35e-3)" "unprognostic (2.26e-1)" "unprognostic (1.67e-1)" "unprognostic (7.08e-2)" "unprognostic (2.33e-1)" 22.5 34.4 28.4 18.3 28.6 26.6 21.4 44.7 36.2 34.1 28.6 26.3 8.7 27.4 23.7 19.3 30.8 15.4 27.1 26.8 35.3 22.9 31.3 22.1 34.2 28.5 29.4 46.3 31.2 29.5 41.5 21.2 28.5 26.1 11.2 84.9 20.7 16.5 60.0 35.1 30.9 15.9 26.4 35.0 22.3 46.9 33.4 32.5 31.4 30.0 29.4 23.1 26.5 33.5 24.4 22.7 55.3 37.3 21.1 27.1 36.4 20.0 31.0 30.3 34.9 23.6 12.5 50.6 23.0 30.0 49.1 19.7 41.6 22.6 38.7 39.7 36.5 53.7 30.0 49.7 35.0 59.4 29.1 31.9 49.4 32.6 40.0 38.6 21.4 35.7 44.7 25.6 25.7 0.3 60.1 42.7 39.8 12.5 27.5 51.3 55.3 39.3 33.4 20.0 28.7 26.8 31.8 14.1 32.9 62.3 19.4 31.5 18.1 23.2 30.6 21.1 26.2 52.7 74.0 71.8 15.5 32.0 17.0 83.7 9.7 34.8 26.1 4.0 19.3 49.0 27.3 21.6 5.1 50.2 33.1 22.0 37.6 25.3 3.7 61.9 23.3 5.1 28.4 28.6 44.7 36.2 26.8 35.3 28.5 29.4 28.5 26.4 33.4 33.5 52.2 0.0 0.0 0.0 36.0 0.0 0.0 0.0 0.0 0.0 36.1 41.4 0.0 0.0 0.0 47.8 0.0 53.6 64.9 0.0 15.6 28.5 0.0 59.5 96.1 14.3 0.0 0.0 0.0 17.0 19.1 18.8 0.0 46.7 0.0 70.7 0.0 0.0 16.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.8 0.0 0.0 9.8 0.0 0.0 0.0 0.0 19.6 0.0 0.0 30.2 0.0 0.0 22.0 0.0 0.0 0.0 0.0 23.8 0.0 0.0 0.0 0.0 36.9 28.2 57.3 0.0 0.0 TUT7 "FLJ13409, KIAA1711, PAPD6, TENT3B, ZCCHC6" ENSG00000083223 "Terminal uridylyl transferase 7" Q5VYS8 9 86287733-86354454 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 80.3;Endometrial stromal cells: 61.1;Glandular and luminal cells: 206.7;Syncytiotrophoblasts: 92.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 114.6" "Group enriched" "Detected in all" 5 "granulocytes: 114.6;monocytes: 47.8" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA020615, HPA020620" Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 85: Liver - Metabolism" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 44: Endometrium - Transcription" Cytosol Nucleoplasm "HPA020615: AB_1858983, HPA020620: AB_1858984" "unprognostic (1.10e-1)" "unprognostic (1.36e-1)" "unprognostic (1.64e-1)" "unprognostic (1.26e-2)" "unprognostic (3.66e-1)" "unprognostic (1.39e-1)" "unprognostic (4.11e-2)" "unprognostic (2.49e-2)" "unprognostic (4.43e-2)" "unprognostic (6.51e-2)" "unprognostic (1.91e-2)" "unprognostic (3.07e-1)" "unprognostic (5.79e-3)" "unprognostic (1.59e-2)" "unprognostic (1.13e-1)" "unprognostic (4.14e-2)" "unprognostic (1.40e-1)" 12.5 9.4 4.8 16.0 6.4 22.6 18.7 5.9 10.0 12.8 10.9 12.1 11.0 9.1 8.9 24.7 8.8 11.3 8.2 5.1 7.9 7.5 38.4 16.5 19.1 9.0 6.3 8.7 13.1 8.7 8.2 14.3 7.8 20.8 11.8 7.7 14.2 7.2 13.6 33.7 12.3 7.8 5.1 20.6 13.6 11.6 9.2 15.1 8.6 9.3 19.2 13.4 16.0 9.0 16.2 17.2 9.8 14.3 22.4 36.0 12.2 21.6 20.5 9.1 10.6 7.8 13.7 22.8 18.9 14.0 9.5 27.3 11.8 12.0 13.5 27.1 6.0 16.5 18.4 13.7 19.3 19.1 21.8 23.5 22.7 14.5 16.2 13.7 15.0 12.3 15.9 24.0 24.6 14.9 16.0 11.0 7.5 25.1 11.1 8.0 17.5 10.1 15.3 31.4 7.2 5.7 13.1 15.5 7.4 11.6 6.4 7.8 24.8 8.7 10.5 15.7 14.8 27.4 23.3 16.5 20.7 10.8 11.8 35.4 19.4 20.5 15.0 24.7 12.5 11.6 8.2 10.7 11.9 12.2 9.5 10.1 114.6 12.8 47.8 5.5 8.8 8.9 4.8 6.4 5.9 10.0 5.1 7.9 9.0 6.3 7.8 5.1 9.2 9.0 28.1 0.0 0.0 0.0 14.5 0.0 0.0 0.0 0.0 0.0 34.2 16.4 0.0 0.0 0.0 9.2 0.0 22.4 36.6 0.0 5.9 29.6 0.0 80.3 61.1 7.2 0.0 0.0 0.0 17.9 17.4 5.6 0.0 206.7 0.0 36.0 0.0 0.0 22.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 26.1 0.0 0.0 12.4 0.0 0.0 0.0 0.0 27.8 0.0 0.0 13.8 0.0 0.0 6.7 0.0 0.0 0.0 0.0 9.1 0.0 0.0 0.0 0.0 92.5 14.8 30.9 0.0 0.0 TXK "BTKL, PSCTK5, PTK4, RLK, TKL" ENSG00000074966 "TXK tyrosine kinase" P42681 4 48066393-48134250 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Adaptive immunity, Immunity, Transcription, Transcription regulation" "Kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "epididymis: 12.4;lymphoid tissue: 15.8" "Cell type enhanced" "Detected in many" "dendritic cells: 84.1;NK-cells: 288.4;T-cells: 52.3" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in some" "Immune cell enhanced" "Detected in many" "NK-cell: 152.3" "Group enriched" "Detected in many" 19 "NK-cells: 152.3;T-cells: 54.8" "Cell line enhanced" "Detected in some" "CAPAN-2: 6.1;HMC-1: 14.0;U-266/70: 6.8;U-266/84: 9.2;WM-115: 32.0" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA062482 Approved Vesicles NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 16: Immune cells - Immune response" "Cluster 17: WM-115 - Nervous system development" "Cluster 63: NK-cells & T-cells - Immune response" Vesicles "HPA062482: AB_2684778" "unprognostic (1.04e-2)" "unprognostic (2.21e-2)" "unprognostic (4.13e-2)" "unprognostic (9.24e-3)" "unprognostic (1.09e-2)" "unprognostic (2.58e-4)" "unprognostic (1.32e-1)" "unprognostic (1.94e-1)" "unprognostic (1.50e-1)" "unprognostic (6.39e-3)" "unprognostic (8.13e-2)" "unprognostic (4.06e-1)" "unprognostic (1.33e-1)" "unprognostic (1.37e-1)" "unprognostic (1.61e-1)" "unprognostic (2.59e-1)" "unprognostic (2.04e-2)" 0.9 1.0 0.1 7.8 0.0 5.6 0.9 0.0 0.4 0.8 0.3 1.5 1.8 1.0 12.4 1.5 2.0 2.2 0.6 0.0 0.5 1.1 2.1 2.8 15.8 1.2 0.2 0.2 0.8 0.4 0.7 1.9 1.5 0.5 1.4 2.0 1.4 0.5 0.6 2.2 5.6 0.4 0.2 10.6 1.1 1.1 0.8 5.7 1.2 0.0 10.8 2.2 0.9 0.2 3.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.5 0.1 6.1 0.0 1.8 0.0 0.2 0.3 0.0 0.1 0.6 0.3 0.1 3.1 0.0 0.0 0.0 0.4 14.0 0.0 0.0 0.1 0.0 0.9 0.2 0.6 0.2 0.1 0.8 0.0 0.0 2.8 0.0 0.8 1.0 0.4 0.0 0.0 1.7 1.6 0.0 0.3 0.0 0.0 1.6 0.1 0.0 0.2 0.5 0.0 0.0 0.4 0.1 6.8 9.2 0.6 0.0 0.5 32.0 5.4 0.1 1.0 42.0 0.2 54.8 0.2 21.1 20.2 0.2 0.1 53.2 37.0 2.4 152.3 0.3 0.6 17.6 36.3 0.1 0.0 0.0 0.4 0.0 0.5 1.2 0.2 1.5 0.2 0.8 0.2 0.7 0.0 1.8 0.3 3.2 0.4 0.6 0.0 0.6 0.5 0.8 0.4 1.1 1.5 0.0 0.0 4.2 0.4 84.1 0.2 1.9 1.5 10.1 2.0 0.4 0.9 0.0 10.7 21.5 0.0 0.1 0.6 0.0 5.5 1.3 0.1 3.6 1.5 1.6 0.0 3.3 0.2 0.0 6.9 0.4 2.8 0.3 1.9 1.8 3.7 1.6 1.4 288.4 0.5 0.5 0.1 0.1 0.0 8.9 0.6 0.4 0.5 0.0 0.4 0.0 1.2 0.1 1.0 0.8 0.8 1.1 0.5 52.3 0.1 0.4 0.8 TYK2 JTK1 ENSG00000105397 "Tyrosine kinase 2" P29597 19 10350529-10380572 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Distal tubular cells: 52.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "NB-4: 206.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA005157 Uncertain Approved Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 19: Monocytes & Neutrophils - Innate immune response" Cytosol "HPA005157: AB_1858480" "unprognostic (1.60e-2)" "unprognostic (6.12e-3)" "unprognostic (3.67e-2)" "prognostic favorable (9.62e-4)" "unprognostic (7.61e-2)" "prognostic favorable (1.05e-5)" "unprognostic (1.20e-2)" "unprognostic (6.16e-3)" "unprognostic (4.93e-2)" "unprognostic (1.90e-2)" "prognostic favorable (1.02e-4)" "unprognostic (1.24e-2)" "prognostic unfavorable (4.43e-4)" "unprognostic (2.10e-3)" "unprognostic (1.78e-1)" "unprognostic (4.19e-1)" "prognostic favorable (4.16e-4)" 53.0 60.5 69.9 37.0 71.9 82.6 52.5 70.7 82.3 55.8 72.2 51.5 29.4 44.8 22.6 46.2 49.0 26.2 65.0 69.6 68.8 77.3 111.2 72.6 51.5 75.1 71.4 56.4 65.1 28.6 66.2 20.1 71.5 64.5 25.7 25.2 50.8 20.6 41.3 51.1 73.9 23.5 70.2 140.8 54.6 16.6 71.8 54.4 60.2 33.7 51.8 49.3 46.0 76.4 29.1 41.1 24.1 38.0 31.9 44.2 23.5 38.9 39.1 48.1 52.2 31.5 18.7 44.5 44.5 43.4 32.8 28.4 29.4 45.5 24.2 78.0 45.5 81.4 90.5 80.2 49.4 34.4 89.4 43.2 31.3 54.5 32.2 29.9 46.5 56.6 35.0 116.1 42.3 90.1 50.7 206.9 7.7 28.4 71.8 49.9 21.1 45.1 40.0 90.1 22.4 28.0 37.6 38.6 28.1 18.4 21.5 57.2 41.1 61.7 22.7 74.1 45.9 97.2 81.4 40.2 32.4 70.8 36.6 9.8 20.8 27.2 12.8 15.2 7.9 7.5 7.6 11.6 23.5 8.0 5.0 7.1 33.0 8.6 15.7 13.0 10.1 13.0 69.9 71.9 70.7 82.3 69.6 68.8 75.1 71.4 71.5 70.2 71.8 76.4 18.6 12.8 17.9 13.1 17.5 6.6 5.4 7.6 13.1 9.2 10.3 11.0 25.7 11.5 11.1 9.2 4.2 7.0 23.2 14.6 52.8 7.6 2.1 10.2 12.6 12.8 4.8 8.6 10.4 11.1 9.7 11.1 27.0 12.0 19.6 17.1 15.4 27.1 14.6 0.0 9.2 8.7 8.2 28.2 14.6 8.8 7.5 30.8 16.0 12.2 25.3 8.7 17.5 11.1 11.1 11.8 12.9 9.8 19.5 5.9 12.1 29.0 11.2 11.0 0.0 10.5 12.6 1.5 4.5 8.8 7.2 6.7 19.4 13.6 11.1 6.3 TYMP "ECGF1, MNGIE" ENSG00000025708 "Thymidine phosphorylase" P19971 22 50525752-50530032 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Angiogenesis, Chemotaxis, Differentiation" "Developmental protein, Glycosyltransferase, Growth factor, Transferase" "Cancer-related genes, Disease variant, FDA approved drug targets, Neuropathy, Primary mitochondrial disease, Progressive external ophthalmoplegia" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Exocrine glandular cells: 643.9;Hofbauer cells: 477.4;Macrophages: 561.7;monocytes: 2174.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in all" 5 "classical monocyte: 135.8;eosinophil: 74.9;intermediate monocyte: 98.4;myeloid DC: 39.5;neutrophil: 114.1;non-classical monocyte: 77.1" "Group enriched" "Detected in all" 10 "dendritic cells: 39.5;granulocytes: 114.1;monocytes: 135.8" "Cell line enhanced" "Detected in many" "CAPAN-2: 40.0;HHSteC: 95.2;Karpas-707: 68.6;U-266/70: 68.6" "Not detected" "Not detected" "HPA000530, HPA001072, CAB002518" Enhanced Approved "Nuclear bodies,Golgi apparatus,Cytosol" NA NA 11000000 "Cluster 52: Eosinophils - Transcription" "Cluster 64: Macrophages - Immune response" "Cluster 29: U-266 - Adaptive immune response" "Cluster 3: Monocytes - Immune response regulation" "Nuclear bodies, Golgi apparatus" Cytosol "CAB002518: AB_563953, HPA000530: AB_2666017, HPA001072: AB_1080274" "unprognostic (7.02e-3)" "unprognostic (1.00e-1)" "unprognostic (3.61e-1)" "prognostic favorable (4.34e-5)" "unprognostic (7.60e-2)" "unprognostic (1.16e-2)" "unprognostic (2.40e-1)" "unprognostic (7.17e-2)" "unprognostic (4.64e-2)" "unprognostic (1.33e-1)" "unprognostic (3.31e-2)" "unprognostic (2.17e-1)" "prognostic unfavorable (3.50e-8)" "unprognostic (1.32e-1)" "unprognostic (4.02e-2)" "unprognostic (1.52e-2)" "unprognostic (4.60e-2)" 46.8 19.5 6.1 77.7 6.0 22.0 37.9 7.1 7.9 32.2 12.7 20.4 26.1 7.8 0.5 58.5 30.0 7.2 26.7 6.4 8.6 38.2 82.0 63.4 31.5 22.1 18.3 4.0 13.8 4.5 8.8 15.4 15.9 21.0 3.6 0.0 40.0 5.6 10.7 24.5 32.5 9.1 10.9 86.1 31.2 3.0 18.0 15.6 25.4 1.6 15.3 22.9 27.0 12.2 27.0 2.5 0.4 0.8 1.8 2.2 5.1 3.7 0.5 6.1 17.4 0.1 40.0 1.8 4.1 5.8 1.3 21.0 0.2 1.0 0.0 9.0 16.5 1.8 3.9 3.5 95.2 1.3 26.9 4.7 4.6 5.4 0.0 0.1 0.1 0.5 2.8 68.6 0.9 1.9 1.5 9.9 0.6 1.9 9.1 5.7 0.4 35.1 0.3 1.2 0.7 5.6 22.9 17.3 6.5 0.2 4.2 13.8 6.7 0.8 4.7 1.5 1.5 68.6 15.9 5.7 1.9 1.5 1.6 19.5 135.8 74.9 2.0 98.4 1.2 6.7 2.9 1.2 39.5 6.9 1.6 1.3 114.1 9.5 77.1 9.3 3.1 10.1 6.1 6.0 7.1 7.9 6.4 8.6 22.1 18.3 15.9 10.9 18.0 12.2 122.6 12.8 29.0 0.3 122.9 58.5 57.4 169.9 53.5 3.4 101.5 90.8 3.2 50.1 88.6 33.1 4.2 17.2 65.8 154.8 29.4 340.2 2.2 55.7 56.0 55.7 16.8 19.6 0.3 643.9 300.8 81.9 38.7 59.2 53.4 3.0 38.2 93.0 477.4 0.0 0.4 50.2 24.4 371.8 409.4 8.7 5.0 561.7 113.8 4.7 2174.6 2.9 71.1 0.5 0.2 364.0 86.4 1.9 102.1 109.8 214.5 105.1 78.0 6.6 26.3 93.3 62.4 1.5 8.0 71.7 56.7 33.5 62.5 3.7 51.1 76.0 TYMS "HsT422, TMS, TS, Tsase" ENSG00000176890 "Thymidylate synthetase" P04818 18 657653-673578 "Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Nucleotide biosynthesis" "Methyltransferase, Transferase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 88.5;lymphoid tissue: 113.6" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 105.8;Erythroid cells: 189.3;Extravillous trophoblasts: 115.3;Plasma cells: 112.7;Spermatocytes: 180.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "T-reg: 14.1" "Group enriched" "Detected in many" 6 "NK-cells: 6.7;T-cells: 14.1" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in some" "CAB002784, HPA074922" Enhanced NA Yes "Cluster 4: T-regs - Cell cycle regulation" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" "CAB002784: , HPA074922: " "unprognostic (7.58e-2)" "unprognostic (2.06e-3)" "unprognostic (9.31e-2)" "unprognostic (2.34e-2)" "unprognostic (7.35e-2)" "unprognostic (1.05e-1)" "prognostic unfavorable (5.10e-6)" "unprognostic (1.62e-3)" "unprognostic (1.68e-2)" "unprognostic (9.82e-2)" "unprognostic (1.07e-3)" "unprognostic (3.28e-2)" "unprognostic (1.23e-2)" "unprognostic (6.34e-2)" "unprognostic (1.66e-1)" "unprognostic (5.65e-3)" "unprognostic (2.47e-1)" 4.5 3.1 4.3 24.2 7.5 88.5 6.7 4.1 6.5 4.8 2.7 22.9 10.5 5.1 1.3 14.8 5.6 3.8 2.2 5.0 4.9 6.5 11.8 4.9 36.1 4.9 5.2 2.1 3.6 1.8 1.6 22.3 4.4 3.1 27.1 4.2 3.9 2.0 0.4 6.2 14.8 12.7 4.8 10.6 8.8 34.3 6.1 113.6 2.1 0.4 44.5 8.4 5.5 10.3 102.7 156.6 320.4 154.9 35.1 57.9 159.9 238.9 141.1 251.7 299.9 132.8 80.1 160.0 91.5 129.9 143.2 45.1 225.3 89.7 216.1 152.3 244.9 273.1 135.8 229.4 8.2 564.8 286.5 51.5 20.7 159.6 49.6 48.4 214.4 334.0 222.0 249.6 321.8 118.1 687.7 311.4 114.7 124.3 114.0 446.8 287.0 191.3 95.6 88.9 106.0 175.7 201.4 91.6 61.1 197.3 63.5 253.5 85.0 289.7 569.5 267.3 474.2 305.9 405.2 367.3 75.2 240.6 339.2 0.0 0.0 1.3 1.1 0.1 0.0 1.1 2.8 2.2 1.8 0.0 0.0 0.6 0.7 6.7 0.1 0.3 14.1 2.9 4.3 7.5 4.1 6.5 5.0 4.9 4.9 5.2 4.4 4.8 6.1 10.3 2.1 0.0 2.3 1.6 15.7 14.4 15.9 13.0 27.9 0.5 7.8 11.7 3.6 2.8 6.7 0.0 0.0 105.8 14.5 15.5 1.9 2.3 34.4 5.6 8.4 12.5 1.2 189.3 0.4 0.8 115.3 28.3 14.3 7.4 7.0 76.2 6.8 4.3 71.4 0.0 0.6 20.9 10.2 15.6 19.4 31.9 6.2 10.7 10.6 1.0 3.9 45.0 5.2 0.5 15.6 1.5 8.9 3.8 112.7 5.0 13.8 36.6 1.0 2.4 13.1 1.3 32.6 180.8 30.7 48.0 7.2 27.0 21.3 10.5 54.9 18.7 TYRO3 "Brt, Dtk, Etk-2, Rek, RSE, Sky, Tif" ENSG00000092445 "TYRO3 protein tyrosine kinase" Q06418 15 41557675-41583589 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Cell adhesion, Host-virus interaction" "Host cell receptor for virus entry, Kinase, Receptor, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 32.0;ovary: 49.7" "Cell type enhanced" "Detected in many" "Excitatory neurons: 42.4;Leydig cells: 44.4;Oligodendrocyte precursor cells: 29.1;Oligodendrocytes: 46.8;Peritubular cells: 47.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "neutrophil: 1.5" "Lineage enriched" "Detected in single" 4 "granulocytes: 1.5" "Cell line enhanced" "Detected in many" "BEWO: 69.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA071245 Approved NA NA 17000000 "Cluster 33: Neutrophils - Chromatin organization" "Cluster 21: Non-specific - Transcription" "Cluster 28: BEWO - Transcription regulation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "HPA071245: AB_2686371" "unprognostic (1.26e-1)" "unprognostic (6.34e-2)" "unprognostic (1.47e-1)" "unprognostic (2.68e-1)" "unprognostic (3.29e-1)" "unprognostic (6.77e-2)" "unprognostic (1.56e-3)" "unprognostic (5.41e-2)" "unprognostic (3.72e-1)" "unprognostic (3.21e-1)" "unprognostic (2.69e-1)" "unprognostic (1.37e-1)" "unprognostic (1.92e-10)" "unprognostic (7.59e-2)" "unprognostic (5.22e-1)" "unprognostic (4.04e-3)" "unprognostic (1.84e-2)" 21.5 3.5 18.2 1.4 30.3 0.8 5.2 17.7 27.1 2.1 0.0 2.3 1.6 4.6 3.5 13.1 11.5 2.5 2.2 27.7 10.7 11.3 0.8 3.3 1.3 20.9 22.6 49.7 9.8 0.9 0.9 5.7 18.6 2.6 0.9 2.6 1.9 6.1 0.9 13.8 2.4 4.4 14.4 5.5 3.2 18.8 15.7 0.4 1.1 1.8 3.7 2.1 4.1 32.0 10.3 6.7 20.7 22.7 18.9 12.8 69.2 14.6 9.3 14.2 13.1 37.7 3.4 0.4 18.3 11.9 19.9 23.7 23.3 3.6 6.5 5.8 15.5 3.2 20.2 18.1 13.3 5.2 0.4 4.1 7.3 10.9 3.6 5.8 10.6 9.8 19.1 4.3 7.9 9.8 2.4 1.0 47.7 16.0 6.7 31.9 18.6 3.8 1.2 19.7 24.6 7.0 13.7 21.6 16.3 29.8 17.8 6.0 8.4 28.0 12.2 21.0 22.5 1.7 3.5 3.1 17.2 33.8 17.2 1.1 0.2 0.2 0.1 0.1 0.1 0.2 0.1 0.2 0.1 0.3 0.2 0.2 1.5 0.3 0.1 0.3 0.1 0.1 18.2 30.3 17.7 27.1 27.7 10.7 20.9 22.6 18.6 14.4 15.7 32.0 3.4 3.2 1.1 17.6 0.9 6.8 8.5 0.4 0.6 2.7 2.2 2.2 2.9 2.8 0.7 3.7 6.2 2.9 1.1 1.3 0.0 3.9 3.6 1.1 13.0 5.4 1.8 0.0 42.4 3.6 10.2 10.5 8.6 1.9 0.0 7.6 9.7 0.4 1.2 0.0 4.6 0.9 0.0 1.9 1.3 5.1 44.4 0.9 8.8 1.0 0.1 8.3 1.0 29.1 46.8 4.6 0.1 47.0 0.3 6.4 1.2 1.2 0.5 4.0 0.0 3.9 4.3 4.0 6.5 4.2 10.9 18.9 0.7 5.8 2.3 5.7 TYW3 "C1orf171, FLJ40918" ENSG00000162623 "TRNA-yW synthesizing protein 3 homolog" Q6IPR3 1 74733152-74766678 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "tRNA processing" "Methyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA029641 Approved Approved "Plasma membrane,Cytosol" No No "Cluster 44: Non-specific - Transcription" "Cluster 89: Fibroblasts - ECM organization" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" Cytosol "Plasma membrane" "HPA029641: AB_2272535" "unprognostic (6.89e-3)" "unprognostic (1.06e-1)" "unprognostic (1.08e-1)" "unprognostic (1.09e-1)" "unprognostic (1.42e-1)" "unprognostic (7.24e-2)" "prognostic unfavorable (1.49e-7)" "unprognostic (3.79e-1)" "unprognostic (2.23e-1)" "unprognostic (2.96e-1)" "unprognostic (4.08e-2)" "unprognostic (1.59e-1)" "unprognostic (1.70e-1)" "unprognostic (1.13e-1)" "unprognostic (2.05e-1)" "unprognostic (8.90e-2)" "unprognostic (2.98e-3)" 12.9 15.4 10.8 11.7 11.8 13.1 17.0 11.3 12.7 13.4 10.2 15.2 8.9 16.0 12.2 11.6 14.7 9.2 20.3 10.5 12.5 17.4 13.8 10.6 14.6 11.2 12.1 26.6 11.7 21.5 11.7 12.7 11.8 15.1 11.1 14.6 14.0 13.6 10.6 9.9 8.9 17.9 11.5 11.0 11.5 11.9 11.6 12.7 19.2 14.4 16.4 15.2 11.1 13.2 19.6 16.1 27.3 19.5 30.3 32.9 41.4 32.9 30.0 30.7 26.9 34.3 16.2 51.0 29.4 28.6 45.1 15.6 31.5 37.9 38.3 31.9 27.1 40.2 49.4 67.0 19.9 81.2 24.9 25.1 37.7 39.2 37.6 24.7 27.7 34.8 70.8 38.0 39.9 16.6 39.8 27.1 72.8 29.2 37.2 37.2 56.8 23.0 26.6 25.2 21.1 18.0 15.7 42.4 53.7 29.5 23.2 29.3 18.2 13.6 37.0 37.0 40.2 21.9 42.7 35.4 30.3 29.0 39.9 9.1 6.4 1.8 10.6 8.8 10.0 10.7 9.2 9.7 9.9 9.8 13.2 14.2 0.5 15.4 6.9 9.6 9.4 5.8 10.8 11.8 11.3 12.7 10.5 12.5 11.2 12.1 11.8 11.5 11.6 13.2 30.6 16.0 23.9 17.6 34.1 25.6 40.5 32.7 58.1 34.5 32.4 42.3 29.9 20.0 28.6 16.5 4.2 44.5 21.2 7.4 78.2 36.2 19.8 28.9 38.8 31.7 13.8 18.5 28.0 59.4 51.1 34.7 15.8 29.0 21.0 32.8 21.8 29.2 33.1 50.5 22.7 19.5 22.4 30.9 22.6 19.6 43.5 26.2 21.4 14.0 39.5 27.6 37.0 30.2 24.5 32.5 8.4 61.3 35.6 45.7 12.2 64.4 18.4 22.5 13.1 44.2 36.0 34.3 45.3 44.1 22.7 22.3 29.2 55.7 25.9 31.2 UAP1 "AgX, AGX1, SPAG2" ENSG00000117143 "UDP-N-acetylglucosamine pyrophosphorylase 1" Q16222 1 162561506-162599842 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Nucleotidyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "hTERT-HME1: 678.4;U-251 MG: 463.5" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA014659 Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" No Yes 48000 "Cluster 16: MAIT-cells - Unknown function" "Cluster 85: Liver - Metabolism" "Cluster 30: Epithelial cell lines - Translation" "Cluster 50: Fibroblasts - ECM organization" "Nucleoplasm, Plasma membrane, Cytosol" "HPA014659: AB_1857409" "unprognostic (2.32e-2)" "unprognostic (2.45e-1)" "unprognostic (2.07e-2)" "unprognostic (1.28e-2)" "unprognostic (2.71e-2)" "unprognostic (1.46e-2)" "unprognostic (1.37e-2)" "unprognostic (1.47e-1)" "unprognostic (2.09e-1)" "unprognostic (1.30e-1)" "unprognostic (1.29e-3)" "unprognostic (4.96e-2)" "prognostic unfavorable (5.12e-5)" "unprognostic (1.59e-1)" "unprognostic (2.04e-1)" "unprognostic (3.51e-1)" "unprognostic (3.45e-2)" 96.0 43.7 12.2 33.7 13.2 51.5 58.8 13.5 14.9 37.1 16.1 65.6 43.9 18.6 29.1 33.9 33.1 39.8 45.1 13.4 13.6 27.0 172.6 36.0 14.1 11.5 16.9 39.9 68.6 12.0 28.9 22.3 11.8 33.3 66.3 20.4 76.6 31.2 41.2 25.0 56.0 24.6 11.6 13.8 55.8 90.9 13.9 11.8 24.4 45.2 22.2 77.9 37.4 11.0 204.6 14.6 39.2 31.5 185.7 147.8 26.8 292.4 107.1 220.7 178.5 38.6 93.5 8.0 64.3 225.8 79.6 35.0 44.7 85.5 359.9 32.4 66.6 36.0 43.8 75.6 87.1 61.8 23.5 69.0 39.8 242.4 678.4 100.6 137.5 62.6 206.1 81.3 298.9 37.4 36.0 40.0 29.2 207.6 64.4 31.9 76.2 99.8 34.8 23.7 41.9 43.4 128.0 78.4 70.4 45.6 38.9 70.0 235.2 110.6 102.5 281.2 463.5 135.0 51.0 67.0 63.4 28.5 71.3 1.4 2.2 11.7 16.7 2.1 20.4 10.7 10.0 17.3 4.6 11.1 9.4 12.0 2.2 8.6 1.2 7.7 5.5 7.2 12.2 13.2 13.5 14.9 13.4 13.6 11.5 16.9 11.8 11.6 13.9 11.0 58.1 6.4 30.2 15.0 42.5 134.7 163.0 47.2 47.8 11.8 59.1 42.7 30.0 27.1 57.4 16.5 8.4 27.2 82.9 94.8 72.4 27.1 78.2 28.6 58.0 35.7 54.9 13.9 12.4 64.7 63.9 195.8 45.9 40.7 33.7 21.3 22.5 98.4 14.5 6.7 12.4 139.4 40.7 10.1 82.2 20.1 50.7 24.6 85.4 3.7 18.2 16.6 41.2 8.0 6.1 73.0 74.5 41.3 152.8 94.6 88.4 26.9 56.0 13.9 19.7 59.4 88.6 212.0 125.9 43.2 81.8 97.7 50.5 18.8 70.4 141.7 UBE2A "HHR6A, HR6A, RAD6A, UBC2" ENSG00000077721 "Ubiquitin conjugating enzyme E2 A" P49459 X 119574536-119591083 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" "Chromatin regulator, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 508.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003875, HPA051765, HPA065898" Supported "Nucleoplasm,Vesicles,Plasma membrane,Cytosol" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 8: Non-specific - Mitochondria" "Cluster 18: U-2197 - ECM organization" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoplasm, Plasma membrane" "Vesicles, Cytosol" "HPA003875: AB_2667061, HPA051765: AB_2681597, HPA065898: AB_2685577" "unprognostic (2.27e-3)" "prognostic favorable (2.16e-4)" "unprognostic (1.12e-1)" "unprognostic (9.09e-2)" "unprognostic (1.63e-1)" "prognostic unfavorable (9.07e-4)" "unprognostic (1.66e-3)" "unprognostic (1.96e-2)" "unprognostic (6.54e-2)" "unprognostic (2.96e-2)" "unprognostic (3.49e-2)" "unprognostic (1.33e-1)" "prognostic unfavorable (2.20e-6)" "unprognostic (9.54e-2)" "unprognostic (3.06e-2)" "unprognostic (1.21e-1)" "unprognostic (7.92e-2)" 40.0 27.4 30.1 39.1 30.6 29.8 29.4 34.1 38.8 34.1 27.1 52.3 37.5 32.0 38.2 53.4 27.3 32.6 63.2 29.6 32.2 41.0 30.1 32.9 46.9 34.4 32.5 20.1 29.2 39.2 18.9 56.8 34.4 31.0 45.0 27.1 30.9 33.0 71.9 30.7 39.1 43.0 32.1 26.8 30.5 17.6 32.1 46.1 30.5 55.0 50.4 46.9 32.8 35.1 129.5 104.1 60.8 54.1 103.0 125.6 63.9 122.6 106.3 141.8 130.3 50.8 84.0 96.4 126.4 133.9 240.6 86.4 86.3 65.7 128.6 142.3 60.6 42.7 71.9 47.1 96.6 105.9 72.1 86.9 90.1 134.0 58.3 98.1 99.4 86.5 57.0 83.6 160.1 134.5 166.6 99.9 106.3 125.7 126.9 84.2 64.0 91.6 113.1 76.6 48.9 51.3 171.2 75.0 93.7 73.2 65.8 92.6 101.5 92.4 42.0 184.3 142.5 83.6 147.1 92.4 99.1 136.3 74.6 46.8 58.5 92.5 43.0 92.1 34.8 52.6 37.9 38.5 74.6 48.7 23.7 33.9 78.0 35.0 101.1 58.5 56.8 51.1 30.1 30.6 34.1 38.8 29.6 32.2 34.4 32.5 34.4 32.1 32.1 35.1 67.5 102.5 40.9 12.7 79.1 124.8 91.6 129.4 51.8 17.2 60.7 43.9 66.7 44.3 80.7 40.5 31.3 179.8 93.0 168.6 101.8 95.4 51.7 75.6 55.3 62.9 45.5 70.4 9.9 102.1 176.2 67.7 37.8 63.0 57.0 35.7 46.4 35.5 131.3 8.4 9.4 49.7 103.7 59.1 183.9 15.3 37.0 97.3 83.6 15.9 129.0 49.8 41.2 14.6 18.0 137.6 132.5 40.6 92.2 98.2 85.6 125.2 107.7 35.0 46.0 56.3 101.1 44.1 32.1 74.6 127.9 508.5 94.8 36.6 54.5 120.3 UBE2B "HHR6B, RAD6B, UBC2" ENSG00000119048 "Ubiquitin conjugating enzyme E2 B" P63146 5 134371469-134392108 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 265.8" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 723.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 444.6" "Lineage enriched" "Detected in all" 6 "granulocytes: 444.6" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003875, HPA051765, HPA065898" Supported "Nucleoplasm,Vesicles,Plasma membrane,Cytosol" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 59: Non-specific - Translation" "Cluster 33: SK-MEL-30 - Melanocyte processes" "Cluster 10: Non-specific - Unknown function" "Nucleoplasm, Plasma membrane" "Vesicles, Cytosol" "HPA003875: AB_2667061, HPA051765: AB_2681597, HPA065898: AB_2685577" "unprognostic (1.98e-1)" "unprognostic (1.35e-1)" "unprognostic (7.39e-2)" "unprognostic (6.66e-2)" "unprognostic (1.44e-1)" "unprognostic (1.48e-2)" "unprognostic (2.56e-1)" "unprognostic (1.27e-1)" "unprognostic (1.91e-1)" "unprognostic (2.44e-1)" "unprognostic (2.49e-1)" "unprognostic (8.39e-2)" "unprognostic (1.64e-3)" "unprognostic (6.30e-3)" "unprognostic (3.42e-2)" "unprognostic (2.04e-1)" "unprognostic (5.52e-2)" 52.5 74.2 31.5 50.0 33.1 84.4 44.2 36.3 53.2 38.3 30.2 48.0 40.7 53.6 34.8 70.5 37.3 51.0 118.4 34.3 34.8 50.6 56.6 44.9 47.1 29.5 31.0 44.4 53.7 25.8 39.9 48.4 31.0 32.9 42.0 29.2 39.7 23.2 265.8 43.1 46.4 43.3 30.3 43.7 39.6 49.2 32.9 29.3 41.2 99.8 48.1 42.8 43.2 36.7 109.4 27.9 58.2 55.0 50.0 54.1 92.7 80.2 43.5 51.4 60.9 85.6 70.9 58.7 94.1 52.3 138.7 42.7 45.8 60.4 56.0 94.5 47.6 32.1 75.9 92.8 58.2 38.8 63.7 46.5 80.2 47.4 39.3 68.1 44.1 48.8 61.1 103.5 46.8 63.4 62.5 102.1 24.9 32.6 26.7 61.6 63.8 83.8 46.6 82.9 77.6 60.1 62.9 29.3 147.9 62.5 63.0 106.0 87.6 57.8 40.8 78.9 89.4 86.1 129.4 87.0 65.2 72.8 59.4 236.7 58.3 174.0 46.9 68.3 42.9 49.7 58.8 48.1 42.6 47.9 69.9 60.6 444.6 53.0 78.9 48.0 77.5 64.1 31.5 33.1 36.3 53.2 34.3 34.8 29.5 31.0 31.0 30.3 32.9 36.7 187.5 73.7 61.6 40.1 176.5 364.7 321.2 215.1 175.8 77.8 169.9 156.5 315.8 147.3 113.7 75.4 81.3 144.5 182.0 183.1 172.1 173.8 233.2 139.8 102.2 149.7 131.8 261.2 103.0 169.5 123.0 183.3 113.2 167.8 116.8 81.7 115.3 97.4 119.4 87.5 84.2 141.0 181.0 131.5 323.9 315.4 155.0 184.2 227.7 49.6 190.6 150.0 113.3 44.7 68.4 210.6 195.2 113.2 162.5 343.9 153.4 170.7 111.7 91.3 151.2 154.9 262.9 223.5 201.7 145.5 369.7 723.5 192.0 140.4 105.7 488.1 UBE2C UBCH10 ENSG00000175063 "Ubiquitin conjugating enzyme E2 C" O00762 20 45812576-45816957 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis, Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 78.5;lymphoid tissue: 113.5" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 129.6;Erythroid cells: 182.1;Extravillous trophoblasts: 449.1;Granulosa cells: 119.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in single" "Immune cell enhanced" "Detected in some" "T-reg: 8.2" "Group enriched" "Detected in many" 5 "granulocytes: 2.1;NK-cells: 2.1;T-cells: 8.2" "Low cell line specificity" "Detected in all" "Group enriched" "Detected in many" 5 "basal ganglia: 4.3;white matter: 11.4" "Low region specificity" "Detected in some" "CAB011464, HPA034569, CAB035990, HPA054975" Approved Approved "Plasma membrane,Cytosol" Yes Yes "Cluster 35: T-regs - Unknown function" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" "Plasma membrane, Cytosol" "CAB011464: AB_442965, CAB035990: , HPA034569: AB_2674226, HPA054975: AB_2682658" "unprognostic (1.45e-2)" "unprognostic (2.19e-1)" "unprognostic (1.06e-1)" "unprognostic (2.11e-3)" "unprognostic (2.54e-1)" "unprognostic (1.35e-1)" "prognostic unfavorable (6.24e-6)" "unprognostic (2.27e-3)" "unprognostic (2.59e-2)" "unprognostic (1.04e-1)" "prognostic unfavorable (6.91e-4)" "unprognostic (3.76e-2)" "prognostic unfavorable (0.00e+0)" "unprognostic (3.09e-1)" "unprognostic (3.61e-1)" "unprognostic (4.65e-2)" "unprognostic (2.68e-1)" 2.6 2.9 0.3 21.5 0.3 78.5 4.3 0.9 0.6 6.1 0.7 26.7 21.4 5.7 0.6 37.2 1.9 2.7 1.4 0.2 0.3 1.9 2.9 5.4 45.3 0.3 0.7 1.3 1.0 0.4 0.4 20.4 0.7 1.5 30.9 0.2 5.0 0.9 0.9 18.5 20.6 10.5 0.2 15.8 13.0 16.4 1.6 113.5 1.1 0.2 69.5 6.9 12.3 0.4 312.8 223.9 390.9 188.3 10.4 24.0 225.2 238.5 121.6 390.7 278.4 743.8 345.4 327.6 233.2 115.5 475.6 294.9 2.2 260.5 395.8 141.7 213.7 101.5 168.5 196.0 3.0 145.4 241.6 7.6 27.8 265.7 257.3 57.4 193.4 206.4 1.8 261.6 325.4 516.2 243.5 41.1 237.1 350.8 529.4 256.0 354.8 1.4 134.9 105.9 226.1 188.7 378.3 271.7 154.4 196.2 276.6 209.4 70.1 341.2 298.4 236.2 473.4 84.3 2.9 369.4 208.0 103.4 328.6 0.0 0.0 0.0 0.1 0.0 0.0 0.9 0.8 1.7 0.6 0.1 0.1 0.1 2.1 2.1 0.5 0.3 8.2 3.2 0.3 0.3 0.9 0.6 0.2 0.3 0.3 0.7 0.7 0.2 1.6 0.4 0.9 0.0 3.7 0.0 17.9 17.3 7.8 39.0 5.7 0.0 8.6 14.6 0.0 1.5 9.3 0.0 0.0 129.6 3.6 27.4 0.0 1.3 12.0 5.8 5.9 9.5 1.2 182.1 0.0 0.5 449.1 28.5 25.5 9.6 5.7 119.0 18.2 3.6 92.6 0.0 0.1 41.1 50.8 20.8 18.1 6.4 0.9 24.1 0.0 0.0 1.1 0.0 0.0 0.0 0.0 1.5 7.2 0.0 37.0 12.6 6.2 0.6 1.8 0.0 0.0 0.5 19.2 52.2 50.7 83.2 11.6 31.2 13.7 2.5 68.4 18.4 UBE2D1 "E2(17)KB1, SFT, UBC4/5, UBCH5, UbcH5A" ENSG00000072401 "Ubiquitin conjugating enzyme E2 D1" P51668 10 58334979-58370751 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 138.7;tongue: 65.3" "Cell type enhanced" "Detected in all" "Basal keratinocytes: 194.4;Suprabasal keratinocytes: 190.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 112.3" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003920 Approved Approved "Plasma membrane,Cytosol" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 19: Monocytes & Neutrophils - Innate immune response" "Plasma membrane, Cytosol" "HPA003920: AB_1858519" "unprognostic (1.12e-1)" "unprognostic (2.08e-1)" "unprognostic (4.23e-3)" "unprognostic (1.76e-1)" "unprognostic (1.52e-2)" "unprognostic (1.21e-2)" "prognostic unfavorable (5.58e-4)" "unprognostic (2.20e-2)" "unprognostic (1.03e-1)" "unprognostic (2.24e-2)" "unprognostic (4.37e-3)" "unprognostic (2.17e-1)" "prognostic unfavorable (8.04e-6)" "unprognostic (9.71e-3)" "unprognostic (4.14e-1)" "unprognostic (1.95e-1)" "unprognostic (5.66e-2)" 13.0 11.8 5.3 16.7 5.7 32.4 7.8 6.6 8.1 8.9 4.4 11.4 7.0 12.6 7.5 11.6 7.1 9.5 33.3 6.1 6.2 8.1 8.3 8.9 13.8 6.6 6.4 8.4 5.5 8.9 3.9 8.9 6.6 9.5 12.0 5.4 5.5 6.7 138.7 5.9 8.3 13.6 6.4 13.4 6.4 4.5 6.3 7.8 8.4 65.3 11.4 15.1 5.6 6.7 19.1 10.2 18.8 24.4 37.5 30.0 12.1 12.4 21.2 13.9 20.3 20.9 16.4 0.0 19.0 18.6 10.3 17.1 36.6 18.0 19.5 19.8 21.2 4.9 3.7 12.2 24.4 15.3 11.8 34.8 19.9 14.4 26.8 18.7 28.1 13.1 10.0 7.8 19.1 6.1 16.5 17.1 23.0 11.7 15.7 13.8 16.9 10.6 21.2 11.2 14.0 18.8 24.2 40.3 20.6 28.5 14.8 10.2 22.8 5.3 18.6 18.2 13.7 19.7 16.4 16.8 16.7 31.3 6.2 10.1 38.5 17.8 6.2 27.1 7.2 8.9 7.3 7.9 20.0 9.8 7.5 6.2 112.3 8.2 23.4 8.3 9.8 23.4 5.3 5.7 6.6 8.1 6.1 6.2 6.6 6.4 6.6 6.4 6.3 6.7 41.6 12.8 11.2 5.5 54.3 194.4 94.1 60.6 46.1 23.7 45.6 45.5 92.4 17.2 39.0 27.6 18.8 29.9 41.7 27.4 76.3 62.3 5.0 32.6 46.9 42.5 41.7 12.0 18.5 42.0 50.4 51.9 38.7 51.2 22.9 19.6 27.5 15.6 73.7 16.8 17.1 40.1 69.2 90.6 104.0 3.0 33.2 147.7 53.4 4.7 94.6 17.9 22.6 12.5 21.2 81.2 52.7 32.4 26.4 108.4 16.1 54.3 33.6 16.1 6.6 51.4 59.1 33.5 19.9 47.1 190.2 149.0 42.8 14.9 28.5 118.2 UBE2D2 "UBC4, UbcH5B" ENSG00000131508 "Ubiquitin conjugating enzyme E2 D2" P62837 5 139526431-139628434 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Transporters" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003920 Approved Approved "Plasma membrane,Cytosol" NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 23: Testis - Cell cycle regulation" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 44: Endometrium - Transcription" "Plasma membrane, Cytosol" "HPA003920: AB_1858519" "unprognostic (1.14e-1)" "unprognostic (2.75e-3)" "prognostic favorable (5.09e-5)" "prognostic favorable (5.90e-4)" "unprognostic (2.33e-1)" "unprognostic (8.19e-3)" "prognostic unfavorable (9.63e-7)" "unprognostic (7.41e-3)" "unprognostic (2.17e-1)" "unprognostic (1.21e-1)" "unprognostic (9.33e-2)" "unprognostic (1.41e-3)" "prognostic unfavorable (2.09e-5)" "unprognostic (8.00e-2)" "unprognostic (1.01e-1)" "unprognostic (4.20e-1)" "unprognostic (1.07e-1)" 78.4 59.9 75.8 66.9 82.0 106.9 72.6 79.3 84.2 84.2 63.0 106.8 46.5 72.8 102.6 89.0 95.0 49.8 93.7 77.9 85.8 80.1 82.6 77.0 83.5 78.7 80.4 64.3 66.5 72.8 62.3 65.5 80.0 57.0 92.8 77.2 61.0 72.3 190.3 77.9 70.4 74.3 81.9 79.3 70.2 135.6 80.1 128.0 61.3 127.3 140.2 79.7 72.8 86.4 175.9 113.9 194.3 137.0 127.9 161.7 125.4 179.6 165.5 204.7 238.6 292.0 160.6 247.8 229.1 185.7 254.0 108.8 192.6 300.2 272.5 162.4 113.7 140.1 115.0 172.1 249.9 136.9 119.7 129.9 152.0 204.9 301.8 177.4 221.8 159.5 125.0 203.1 192.9 175.5 215.3 197.2 108.1 60.4 124.0 162.7 198.1 179.6 220.4 202.0 177.5 117.0 157.1 198.7 309.4 413.4 125.2 121.6 148.9 156.4 87.6 132.5 223.5 146.0 260.0 343.8 112.3 223.2 128.0 44.1 57.0 115.9 57.7 53.7 62.1 89.2 82.1 80.9 63.3 90.7 102.5 90.3 90.7 65.1 66.2 106.1 110.8 58.0 75.8 82.0 79.3 84.2 77.9 85.8 78.7 80.4 80.0 81.9 80.1 86.4 137.1 32.1 69.8 35.9 215.4 171.8 182.3 204.8 112.7 76.3 124.8 146.9 96.4 124.4 96.5 68.0 81.3 181.4 205.8 158.0 215.2 208.4 637.0 457.2 94.2 131.0 123.4 148.8 62.0 178.4 228.0 104.8 77.5 230.9 138.8 119.4 109.9 80.6 178.0 94.2 54.4 120.8 142.4 136.4 203.4 550.0 104.4 150.8 152.9 49.6 189.5 170.7 234.8 38.2 65.7 228.7 127.1 93.6 237.3 234.8 123.8 200.9 63.9 105.1 118.3 102.2 171.2 459.7 152.5 149.4 203.7 249.6 217.1 111.7 160.4 247.1 UBE2D3 UbcH5C ENSG00000109332 "Ubiquitin conjugating enzyme E2 D3" P61077 4 102794383-102868896 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003920 Uncertain Approved "Plasma membrane,Cytosol" NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 10: Non-specific - Unknown function" "Plasma membrane, Cytosol" "HPA003920: AB_1858519" "unprognostic (7.43e-2)" "unprognostic (3.19e-1)" "unprognostic (1.27e-2)" "unprognostic (5.78e-2)" "unprognostic (6.44e-2)" "unprognostic (4.96e-2)" "unprognostic (1.17e-1)" "unprognostic (8.44e-3)" "unprognostic (1.14e-1)" "unprognostic (1.95e-1)" "unprognostic (5.75e-2)" "unprognostic (3.31e-2)" "prognostic favorable (4.51e-4)" "unprognostic (5.08e-2)" "unprognostic (2.79e-1)" "unprognostic (4.54e-2)" "unprognostic (1.34e-2)" 182.7 171.7 85.7 172.0 92.6 478.3 141.9 101.1 120.6 127.1 93.4 154.9 154.0 125.3 113.8 173.4 125.9 142.5 149.4 92.1 103.9 172.2 251.4 175.3 189.6 102.5 96.0 131.5 154.2 133.5 98.4 159.0 99.8 106.8 144.4 129.0 116.7 102.1 243.6 136.4 158.3 129.9 101.4 149.5 144.4 127.0 95.6 198.5 159.2 197.9 197.0 185.6 128.0 113.7 301.6 169.1 275.4 223.4 286.2 408.0 235.9 301.2 395.1 260.1 243.6 257.4 416.4 319.3 190.6 304.4 336.8 168.6 294.7 400.8 352.5 299.6 149.8 292.0 165.8 209.6 300.3 415.5 240.4 314.0 247.9 288.6 398.9 334.3 343.4 258.7 372.9 316.4 350.9 243.1 613.4 235.1 200.2 341.0 167.1 318.4 269.9 231.5 261.5 283.7 275.6 232.1 183.5 464.8 349.6 318.2 193.0 241.0 318.4 270.0 231.1 179.2 276.3 277.9 389.8 491.3 288.2 227.2 297.0 614.9 253.7 394.0 163.5 256.0 216.3 165.9 203.4 194.4 217.6 139.2 205.8 190.5 817.2 215.7 271.9 149.8 229.6 422.1 85.7 92.6 101.1 120.6 92.1 103.9 102.5 96.0 99.8 101.4 95.6 113.7 303.4 166.7 193.1 98.9 291.7 844.0 693.9 408.2 233.9 133.7 251.5 166.9 229.8 193.0 242.3 139.8 125.1 311.5 317.4 336.1 547.8 361.0 779.4 257.1 246.7 344.0 240.8 348.7 159.7 382.2 561.6 286.0 202.3 371.3 224.9 154.8 193.1 235.7 392.9 122.8 145.8 283.8 303.2 403.0 825.6 635.1 164.7 415.1 357.5 111.5 399.4 160.0 280.2 104.5 185.0 454.4 347.2 149.0 296.4 612.3 335.8 428.8 242.4 170.6 105.2 270.6 531.9 217.2 180.7 258.2 813.3 638.4 382.5 172.3 268.2 784.3 UBE2D4 HBUCE1 ENSG00000078967 "Ubiquitin conjugating enzyme E2 D4 (putative)" Q9Y2X8 7 43926436-43956136 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 32.5" "Cell type enhanced" "Detected in many" "Distal tubular cells: 54.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "SH-SY5Y: 30.2" "Low region specificity" "Detected in all" HPA003920 Approved Approved "Plasma membrane,Cytosol" NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 80: Striated muscle - Unknown function" "Cluster 13: SH-SY5Y - Nervous system development" "Cluster 7: Non-specific - Mitochondria" "Plasma membrane, Cytosol" "HPA003920: AB_1858519" "unprognostic (9.95e-3)" "unprognostic (6.76e-2)" "unprognostic (6.87e-2)" "unprognostic (8.94e-2)" "unprognostic (8.24e-2)" "unprognostic (5.24e-2)" "unprognostic (2.42e-1)" "unprognostic (3.58e-3)" "unprognostic (4.74e-2)" "unprognostic (5.04e-2)" "prognostic favorable (4.86e-4)" "prognostic favorable (5.77e-4)" "prognostic favorable (6.51e-4)" "unprognostic (1.11e-1)" "unprognostic (8.74e-3)" "unprognostic (1.89e-1)" "unprognostic (1.34e-1)" 5.8 8.3 11.7 2.4 12.2 2.2 5.0 14.2 17.6 4.6 9.8 6.5 2.4 4.5 5.7 5.2 4.5 3.4 10.9 12.3 11.2 6.9 10.7 4.4 2.7 12.0 11.7 5.1 10.0 4.6 5.1 2.8 11.9 5.7 2.9 6.9 5.6 4.4 32.5 4.9 3.9 4.4 11.8 4.7 4.6 3.0 11.5 2.7 4.9 27.8 2.7 5.3 5.2 12.7 4.9 4.0 2.4 11.0 11.0 4.5 1.8 2.3 5.8 2.9 3.7 2.1 5.6 4.6 6.3 6.3 8.1 5.3 3.1 2.5 4.4 10.5 5.4 5.0 5.8 5.4 4.1 10.9 9.8 3.4 5.2 3.3 5.0 4.2 3.6 5.5 5.6 9.2 4.0 3.0 6.5 6.1 5.4 5.9 5.1 4.0 3.3 7.1 6.2 5.9 8.8 30.2 5.0 9.7 3.8 4.4 4.9 3.3 3.2 1.9 6.0 4.1 6.9 13.5 10.8 2.2 5.7 14.2 10.9 10.2 14.5 17.5 11.1 23.8 11.4 12.8 13.5 12.5 15.1 12.7 16.2 13.4 1.4 9.9 28.7 13.0 12.6 8.8 11.7 12.2 14.2 17.6 12.3 11.2 12.0 11.7 11.9 11.8 11.5 12.7 14.9 0.0 6.5 8.8 10.4 6.2 9.1 9.4 4.0 9.6 24.3 24.3 24.6 14.3 10.0 16.5 2.1 11.9 11.9 8.4 54.8 18.7 6.2 8.9 7.2 12.9 18.7 9.9 14.2 28.4 20.3 14.9 8.2 8.7 4.5 11.1 12.5 25.4 27.4 11.8 13.5 8.0 8.2 11.6 14.1 10.7 12.2 12.5 16.0 8.4 18.4 18.8 5.2 20.1 12.1 14.1 7.6 21.8 11.2 12.1 15.5 52.0 5.5 11.6 6.6 23.0 10.5 15.6 9.6 10.8 11.2 7.7 8.8 16.5 8.4 12.3 UBE2E1 UbcH6 ENSG00000170142 "Ubiquitin conjugating enzyme E2 E1" P51965 3 23805955-23891640 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA030445, CAB073413" Approved Approved Nucleoplasm NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 25: RPMI-8226 - Immune response" "Cluster 26: Respiratory epithelial cells - Mucosal defense" Nucleoplasm "CAB073413: , HPA030445: AB_10669599" "unprognostic (7.50e-2)" "unprognostic (2.78e-2)" "unprognostic (7.91e-3)" "unprognostic (7.13e-2)" "unprognostic (6.74e-3)" "unprognostic (1.74e-1)" "prognostic unfavorable (9.97e-7)" "unprognostic (3.69e-2)" "unprognostic (3.53e-2)" "unprognostic (1.34e-2)" "unprognostic (5.36e-3)" "unprognostic (2.70e-2)" "unprognostic (2.40e-2)" "unprognostic (1.94e-1)" "unprognostic (2.94e-1)" "unprognostic (2.75e-1)" "unprognostic (1.93e-1)" 68.6 54.9 84.5 67.1 91.0 123.2 89.5 91.5 121.1 74.7 83.9 76.9 50.6 66.6 68.3 80.9 63.5 61.8 62.6 82.4 94.1 69.3 71.2 71.2 102.4 92.5 88.7 79.3 53.9 103.7 34.4 96.1 93.8 71.3 79.0 73.1 64.6 73.6 89.4 63.8 51.4 77.5 93.2 73.8 60.9 51.7 87.2 98.5 61.4 94.9 108.1 92.5 65.1 101.8 199.3 101.7 202.1 99.1 129.2 170.3 151.5 141.0 256.8 172.7 234.0 80.1 235.8 182.6 121.2 166.3 146.8 65.6 232.5 208.6 228.2 202.2 201.4 235.5 75.8 97.3 177.0 260.2 138.8 172.6 162.8 230.4 324.9 207.1 278.6 118.9 177.2 210.8 136.0 86.7 188.6 235.8 268.0 117.8 255.3 201.6 80.7 531.0 262.0 129.3 54.3 176.0 146.7 131.5 215.5 202.5 146.4 329.1 183.1 132.2 144.2 85.9 109.5 154.9 99.8 363.6 152.2 231.9 110.9 1.7 4.2 3.7 1.8 4.7 2.9 3.0 2.4 1.8 3.8 2.8 3.2 2.0 1.5 4.3 2.8 4.0 2.0 2.1 84.5 91.0 91.5 121.1 82.4 94.1 92.5 88.7 93.8 93.2 87.2 101.8 30.7 44.8 28.9 66.3 52.7 72.3 62.6 89.0 59.2 31.3 37.9 24.9 68.2 31.5 59.5 18.4 4.2 97.3 27.9 56.7 56.7 90.4 25.6 37.0 28.7 58.4 46.3 41.0 47.1 78.0 99.4 43.2 25.5 32.7 40.6 40.2 43.5 22.5 98.8 20.2 50.6 37.9 150.5 69.4 156.5 55.3 40.7 61.5 97.8 127.4 98.9 81.6 36.0 90.5 102.8 71.8 61.9 48.5 40.8 78.0 21.5 43.4 60.1 27.7 52.6 47.1 63.0 35.4 59.5 61.7 90.2 72.1 35.7 27.6 52.2 72.6 UBE2E2 "FLJ25157, UbcH8" ENSG00000182247 "Ubiquitin conjugating enzyme E2 E2" Q96LR5 3 23203020-23591794 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 652.7;Inhibitory neurons: 399.4;Microglial cells: 402.8;Oligodendrocyte precursor cells: 513.2;Oligodendrocytes: 845.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in many" 6 "classical monocyte: 41.7;intermediate monocyte: 50.3;memory B-cell: 35.1;myeloid DC: 57.6;naive B-cell: 40.1;non-classical monocyte: 54.4;plasmacytoid DC: 74.0" "Group enriched" "Detected in all" 6 "B-cells: 40.1;dendritic cells: 74.0;monocytes: 54.4" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003303, HPA028872, HPA030445, CAB073417" Approved Approved Nucleoplasm No No "Cluster 23: Antigen presenting cells - Antigen presentation" "Cluster 68: Epididymis - Unknown function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "CAB073417: , HPA003303: AB_1858521, HPA028872: AB_10966277, HPA030445: AB_10669599" "unprognostic (2.20e-1)" "unprognostic (2.30e-1)" "unprognostic (1.52e-2)" "unprognostic (3.68e-3)" "unprognostic (3.74e-2)" "unprognostic (1.70e-1)" "unprognostic (9.19e-3)" "unprognostic (3.11e-3)" "unprognostic (1.32e-1)" "unprognostic (1.20e-1)" "unprognostic (4.20e-1)" "unprognostic (4.59e-2)" "unprognostic (1.60e-1)" "unprognostic (1.44e-2)" "unprognostic (2.68e-2)" "unprognostic (3.11e-2)" "unprognostic (6.11e-3)" 23.9 8.9 14.3 10.6 17.2 7.0 18.3 14.5 28.1 22.9 9.4 18.2 4.6 18.2 25.7 17.4 13.7 15.4 19.9 20.2 16.8 17.1 13.4 17.8 16.4 13.2 12.8 16.2 7.0 13.5 12.0 7.4 14.4 14.7 4.8 16.6 11.9 13.3 16.0 16.8 8.3 18.9 12.6 14.3 11.6 15.1 13.7 18.1 13.9 12.4 12.6 16.2 17.8 28.4 36.7 12.9 33.3 0.6 29.0 32.1 30.3 22.6 38.2 20.8 29.0 3.6 29.2 31.7 15.1 19.9 28.5 3.5 24.5 35.2 26.5 0.2 24.6 0.0 15.3 4.3 20.8 0.0 24.5 25.6 36.2 30.0 50.0 21.1 20.2 24.5 1.9 32.4 19.0 5.9 16.8 7.2 23.7 20.7 18.6 34.9 13.0 36.8 20.4 0.8 8.5 17.7 24.8 14.4 0.4 23.8 30.7 20.9 17.8 20.4 29.1 13.8 25.7 31.2 10.9 49.4 19.2 14.2 5.8 0.1 41.7 0.2 0.7 50.3 0.9 35.1 1.4 0.6 57.6 40.1 9.1 3.5 1.1 2.5 54.4 74.0 0.7 15.7 14.3 17.2 14.5 28.1 20.2 16.8 13.2 12.8 14.4 12.6 13.7 28.4 13.3 22.4 9.8 159.3 48.4 25.6 12.2 77.2 34.7 24.0 31.3 27.1 38.2 15.7 28.1 31.3 16.7 34.8 24.2 0.9 68.4 12.0 24.2 9.6 30.8 24.6 1.8 8.2 652.7 29.2 43.1 42.1 5.6 18.8 0.0 38.5 14.6 41.4 47.7 32.0 399.4 1.1 67.1 47.3 73.9 16.0 39.4 49.2 78.2 402.8 40.5 14.8 1.0 513.2 845.2 13.9 1.2 53.0 32.8 64.6 0.0 152.7 17.3 3.6 32.9 14.9 67.3 36.3 91.0 44.1 42.3 38.6 4.6 15.1 0.7 8.6 UBE2E3 UbcH9 ENSG00000170035 "Ubiquitin conjugating enzyme E2 E3" Q969T4 2 180967248-181076585 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Growth regulation, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "AF22: 654.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003303, HPA030445" Approved NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 80: Striated muscle - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 10: Non-specific - Unknown function" "HPA003303: AB_1858521, HPA030445: AB_10669599" "unprognostic (8.85e-2)" "unprognostic (1.77e-1)" "unprognostic (1.51e-1)" "unprognostic (2.96e-2)" "unprognostic (2.23e-1)" "prognostic unfavorable (8.08e-5)" "prognostic unfavorable (9.11e-4)" "unprognostic (1.00e-3)" "unprognostic (4.99e-2)" "unprognostic (8.46e-2)" "prognostic unfavorable (1.78e-5)" "unprognostic (8.75e-2)" "unprognostic (3.86e-1)" "unprognostic (2.50e-1)" "unprognostic (1.28e-1)" "unprognostic (2.18e-1)" "unprognostic (4.40e-1)" 61.6 45.8 57.8 40.1 60.8 48.3 58.1 59.9 71.5 56.2 51.4 51.4 46.7 51.6 55.8 46.7 58.3 71.4 54.2 74.3 59.7 71.8 58.3 39.9 39.6 56.6 57.8 52.5 56.5 79.4 35.3 48.6 58.0 40.0 54.4 68.4 54.6 39.6 175.1 57.0 42.5 42.9 62.3 40.3 59.2 56.8 58.8 67.9 73.7 88.6 48.4 61.6 46.9 64.1 104.8 46.6 654.4 22.8 189.8 243.1 104.0 137.1 171.9 112.8 139.2 51.0 124.0 51.4 117.1 188.5 94.5 43.8 400.7 140.5 202.1 125.9 120.3 177.2 59.0 142.5 91.6 83.5 81.3 96.7 127.9 99.3 94.8 114.6 150.9 105.4 91.9 93.3 280.7 57.5 152.6 77.7 125.6 71.2 217.6 147.0 66.8 122.1 193.2 91.1 113.4 126.3 59.7 62.8 58.1 178.3 33.7 121.5 140.1 218.2 143.2 129.4 162.0 81.1 55.0 143.7 215.7 32.6 124.3 29.1 28.2 53.7 17.6 25.4 21.3 15.0 13.6 22.7 18.4 9.5 14.3 15.7 25.6 18.5 36.3 60.0 5.9 20.5 57.8 60.8 59.9 71.5 74.3 59.7 56.6 57.8 58.0 62.3 58.8 64.1 69.3 9.6 24.2 100.9 50.3 102.9 83.7 111.2 70.6 151.8 84.4 74.4 37.7 108.7 63.7 55.2 29.2 31.9 84.8 56.4 229.0 95.8 36.9 54.3 51.6 59.8 59.8 108.8 115.4 101.9 83.4 81.2 60.6 57.8 23.5 61.8 72.1 55.9 85.3 75.7 67.7 39.4 91.6 71.4 63.9 79.7 62.7 76.3 129.9 71.2 62.4 103.9 79.3 160.9 158.3 113.7 41.6 36.1 87.7 74.8 58.9 172.6 51.8 73.3 26.3 56.4 81.7 83.1 191.6 77.3 122.3 36.0 55.4 57.9 50.9 103.4 UBE2F NCE2 ENSG00000184182 "Ubiquitin conjugating enzyme E2 F (putative)" Q969M7 2 237966827-238042782 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 282.2;monocytes: 215.5;NK-cells: 193.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" HPA037444 Approved Approved Cytosol NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 39: Non-specific - Mitochondria" "Cluster 30: Epithelial cell lines - Translation" "Cluster 38: Extravillous trophoblasts - Unknown function" Cytosol "HPA037444: AB_10672491" "unprognostic (1.73e-1)" "unprognostic (1.65e-1)" "unprognostic (3.80e-2)" "unprognostic (6.92e-3)" "unprognostic (3.39e-1)" "unprognostic (1.56e-1)" "prognostic unfavorable (2.72e-4)" "unprognostic (3.43e-3)" "unprognostic (6.64e-2)" "unprognostic (3.87e-1)" "unprognostic (1.69e-2)" "unprognostic (2.04e-1)" "prognostic unfavorable (1.59e-7)" "unprognostic (2.04e-2)" "unprognostic (6.39e-2)" "unprognostic (3.60e-2)" "unprognostic (2.51e-1)" 26.7 29.7 33.0 25.5 33.7 41.8 22.8 35.9 40.6 27.7 32.5 29.6 24.7 23.1 53.0 43.1 18.8 28.7 56.7 33.4 38.0 28.2 44.2 22.6 32.1 37.5 37.7 12.6 70.5 41.8 21.0 39.9 38.7 25.4 33.7 16.0 25.2 30.3 60.7 18.8 26.9 35.6 35.5 23.7 26.5 26.0 36.1 34.5 35.4 69.1 33.1 40.7 23.5 38.3 42.9 23.9 53.6 55.1 69.2 83.0 74.8 38.9 55.5 43.3 44.4 26.0 26.4 22.0 13.7 88.7 93.7 35.1 62.3 84.9 67.9 33.7 22.7 31.6 28.5 86.6 86.2 13.1 70.1 48.1 137.7 57.9 87.1 40.1 78.1 100.8 94.2 13.7 80.1 64.0 35.1 55.9 59.8 60.9 33.8 41.8 35.0 39.1 66.3 17.8 36.0 53.0 45.2 36.2 77.0 89.4 31.0 52.8 49.7 47.6 41.7 54.9 43.1 17.1 14.3 43.6 57.1 38.4 35.8 112.4 50.0 63.8 66.3 68.2 26.2 26.2 44.8 40.4 45.0 25.4 40.7 41.4 37.3 102.3 78.5 56.4 51.6 63.6 33.0 33.7 35.9 40.6 33.4 38.0 37.5 37.7 38.7 35.5 36.1 38.3 17.6 6.4 18.4 0.0 26.4 32.5 24.1 33.0 11.4 24.2 37.7 24.9 48.1 30.0 21.6 27.6 8.4 84.9 87.3 38.6 56.7 49.7 23.6 15.0 23.9 27.1 41.8 102.5 0.0 79.4 282.2 24.9 15.8 13.8 21.5 13.1 22.1 41.7 152.7 26.9 0.0 58.1 32.6 72.2 105.7 61.3 25.7 67.6 35.6 0.0 215.5 28.3 193.6 0.0 0.0 71.8 31.9 30.9 25.7 46.0 49.7 62.2 23.4 21.7 39.5 14.8 31.4 123.5 79.4 19.0 40.3 65.7 36.2 16.0 35.5 34.6 UBE2G1 "UBC7, UBE2G" ENSG00000132388 "Ubiquitin conjugating enzyme E2 G1" P62253 17 4269259-4366628 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 210.2" "Cell type enhanced" "Detected in all" "Basal keratinocytes: 286.0;Late spermatids: 248.3;Suprabasal keratinocytes: 239.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA045681, HPA050551" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 13: T-cells - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 28: Keratinocytes - Keratinization" "Nucleoplasm, Cytosol" "HPA045681: AB_2679417, HPA050551: AB_2681171" "unprognostic (1.57e-3)" "unprognostic (1.94e-1)" "unprognostic (2.34e-2)" "unprognostic (1.80e-2)" "unprognostic (5.16e-2)" "unprognostic (5.84e-2)" "unprognostic (1.87e-1)" "unprognostic (2.64e-2)" "unprognostic (5.13e-2)" "unprognostic (1.86e-1)" "unprognostic (2.80e-1)" "unprognostic (1.67e-2)" "unprognostic (9.99e-2)" "unprognostic (2.16e-1)" "unprognostic (4.58e-2)" "unprognostic (3.97e-2)" "unprognostic (6.50e-2)" 21.0 19.1 15.8 25.4 21.4 31.5 20.1 21.0 24.3 25.2 11.6 39.7 22.5 22.7 14.7 52.2 16.3 16.0 37.9 16.1 18.7 27.0 30.3 15.6 38.8 21.5 19.2 15.6 18.4 21.5 9.7 18.9 21.7 22.6 24.2 17.5 21.0 20.8 210.2 28.0 23.6 27.2 20.3 20.7 21.8 23.2 21.0 24.9 16.1 84.1 46.4 24.5 32.1 26.5 54.5 57.8 52.7 38.9 42.2 44.3 74.9 51.7 41.4 48.2 42.1 40.0 27.0 84.5 52.8 51.2 39.4 57.2 66.3 48.1 77.2 44.8 53.9 31.7 28.6 45.9 41.3 46.5 57.4 38.0 70.3 45.8 66.1 33.8 65.6 55.8 56.5 88.9 40.1 24.3 59.4 42.5 58.2 40.1 29.6 76.1 27.9 78.1 56.4 35.1 22.7 42.3 48.9 41.8 41.6 77.4 41.1 29.9 49.6 48.1 36.8 57.0 58.7 34.3 43.8 118.9 36.9 42.8 37.7 13.3 15.8 39.0 22.2 16.8 29.9 34.1 28.3 29.1 20.2 24.4 28.3 28.9 28.1 32.5 18.6 14.8 28.9 21.8 15.8 21.4 21.0 24.3 16.1 18.7 21.5 19.2 21.7 20.3 21.0 26.5 28.3 22.4 14.4 31.3 70.6 286.0 36.5 47.8 111.5 18.8 47.0 31.0 67.6 27.1 32.2 25.8 6.2 47.0 47.8 41.4 82.2 30.9 139.5 36.7 25.7 35.5 38.4 26.5 47.9 26.7 59.6 31.1 32.6 39.9 21.0 13.9 31.1 62.3 48.1 15.2 46.3 38.3 44.7 36.5 81.1 248.3 19.6 35.7 67.6 30.9 43.1 28.7 36.0 36.2 84.4 43.0 30.4 21.1 154.3 65.7 40.4 75.6 35.4 17.1 6.6 25.9 43.5 70.8 50.8 85.3 239.7 66.8 58.2 13.8 30.1 54.0 UBE2G2 UBC7 ENSG00000184787 "Ubiquitin conjugating enzyme E2 G2" P60604 21 44768580-44801826 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Late spermatids: 211.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003332 Approved NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 39: Non-specific - Mitochondria" "Cluster 16: U-266 - Nucleosome" "Cluster 31: Spermatids - Spermatogenesis" "HPA003332: AB_1858525" "unprognostic (7.58e-2)" "unprognostic (5.41e-2)" "unprognostic (1.58e-2)" "unprognostic (4.45e-2)" "unprognostic (6.30e-2)" "unprognostic (4.67e-2)" "unprognostic (5.99e-2)" "unprognostic (3.79e-3)" "unprognostic (6.93e-3)" "unprognostic (7.02e-2)" "unprognostic (1.40e-2)" "unprognostic (6.98e-3)" "prognostic unfavorable (7.02e-5)" "unprognostic (1.79e-1)" "unprognostic (1.69e-1)" "unprognostic (2.75e-2)" "unprognostic (3.55e-2)" 26.7 20.9 21.1 13.4 22.8 25.9 17.5 21.9 24.7 13.5 20.0 22.2 13.3 20.2 8.4 16.1 16.3 12.1 34.7 21.3 21.8 24.4 27.6 16.9 16.2 22.4 22.3 13.7 26.7 20.5 8.2 14.2 22.6 14.8 14.1 20.7 12.6 21.3 61.3 15.3 16.6 20.4 22.1 19.7 21.6 12.2 22.0 22.9 16.9 51.8 14.9 21.2 12.5 24.2 51.9 11.5 34.9 44.3 46.2 20.6 31.3 37.0 27.5 29.5 31.7 40.5 6.7 66.4 33.4 35.8 38.6 20.5 49.4 43.5 27.2 61.9 51.1 107.3 7.0 33.6 35.5 79.2 19.4 33.3 50.0 39.5 39.5 14.7 47.0 71.3 99.8 47.9 43.0 24.6 89.2 13.3 86.7 35.4 44.2 73.2 31.1 61.2 41.4 28.3 39.3 72.5 49.6 18.2 52.3 30.5 17.6 68.5 37.3 31.1 21.2 28.5 58.5 73.8 144.7 64.1 29.3 96.1 36.3 3.2 16.1 8.5 20.8 16.8 22.8 16.0 19.0 21.5 17.3 16.2 20.1 21.3 4.9 20.8 20.1 24.6 21.1 17.4 21.1 22.8 21.9 24.7 21.3 21.8 22.4 22.3 22.6 22.1 22.0 24.2 54.6 57.7 115.4 70.8 48.3 47.7 38.4 32.0 39.3 58.8 37.3 34.0 70.6 28.6 48.4 53.3 66.7 40.7 53.3 29.8 25.4 32.9 63.4 36.8 68.5 54.1 30.0 37.4 56.3 40.7 26.3 41.3 26.0 49.7 43.6 66.6 37.1 69.7 35.3 32.0 57.5 31.2 26.4 42.2 37.4 211.1 41.3 42.9 28.4 32.8 43.2 39.5 49.4 73.9 56.7 43.2 21.5 50.4 53.6 55.6 27.4 36.7 43.0 102.2 26.3 59.3 42.8 42.9 49.4 44.9 56.0 35.8 49.4 75.6 46.0 40.9 UBE2H "GID3, UBC8, UBCH" ENSG00000186591 "Ubiquitin conjugating enzyme E2 H" P62256 7 129830732-129952960 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Glandular and luminal cells: 365.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003302 Approved Approved Mitochondria NA NA 21000 "Cluster 24: B-cells - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 44: Endometrium - Transcription" Mitochondria "HPA003302: AB_1858526" "unprognostic (1.15e-1)" "unprognostic (5.85e-2)" "unprognostic (5.67e-3)" "unprognostic (2.76e-1)" "unprognostic (2.25e-1)" "unprognostic (3.08e-2)" "unprognostic (1.13e-1)" "unprognostic (1.37e-1)" "unprognostic (9.43e-2)" "unprognostic (6.19e-2)" "prognostic unfavorable (2.33e-5)" "unprognostic (1.13e-1)" "unprognostic (3.73e-2)" "unprognostic (2.37e-1)" "unprognostic (1.12e-1)" "unprognostic (3.58e-1)" "unprognostic (1.23e-1)" 46.8 64.7 43.0 29.1 44.2 42.3 34.4 46.4 49.1 44.7 58.7 42.3 23.4 44.3 37.6 49.9 44.6 44.6 98.2 42.1 45.4 42.1 44.2 38.8 31.8 48.7 43.4 41.7 84.3 49.2 29.4 52.5 45.0 36.1 26.0 42.0 39.3 41.5 69.3 31.2 24.4 49.2 41.8 28.6 34.6 36.4 45.8 37.4 45.0 60.6 39.8 40.1 33.7 47.8 82.6 43.8 58.5 56.1 126.1 107.5 86.5 72.0 97.8 45.8 51.1 22.9 92.5 34.0 87.4 76.6 123.8 62.5 46.2 81.6 59.5 40.9 22.6 11.5 63.5 28.6 98.3 23.6 36.8 146.7 106.9 61.3 99.7 106.3 89.7 36.3 27.5 104.1 71.5 29.9 31.1 26.1 80.0 60.5 49.8 24.4 27.8 77.2 95.9 106.5 20.3 59.6 68.3 164.7 43.8 166.0 17.1 27.2 89.1 51.7 24.2 72.2 76.5 83.5 65.6 58.5 102.1 28.9 49.7 2.2 1.4 3.4 2.8 1.2 3.8 2.3 2.8 2.6 1.3 4.5 3.6 3.8 4.8 0.9 1.5 2.3 4.4 1.3 43.0 44.2 46.4 49.1 42.1 45.4 48.7 43.4 45.0 41.8 45.8 47.8 69.9 41.7 51.8 87.1 43.1 145.8 187.5 65.7 59.7 65.1 83.7 49.4 102.9 44.3 69.3 71.7 60.5 116.3 56.7 38.6 41.1 66.0 93.5 225.7 91.2 81.4 59.1 100.0 97.1 70.9 67.1 65.2 43.8 365.8 14.7 53.9 45.3 73.1 41.8 43.7 116.9 35.3 54.9 40.3 69.8 44.0 44.1 52.0 48.0 89.0 26.2 87.4 51.5 113.1 108.5 118.3 33.6 78.6 60.5 227.6 27.6 49.7 95.3 35.6 13.1 65.9 69.0 46.5 22.5 78.6 153.7 200.4 49.2 79.7 26.6 274.3 UBE2J1 "CGI-76, HSPC153, NCUBE1, UBC6" ENSG00000198833 "Ubiquitin conjugating enzyme E2 J1" Q9Y385 6 89326625-89352722 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 5 "Early spermatids: 498.7;Late spermatids: 1426.6;Plasma cells: 1003.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in many" "Daudi: 294.1;Karpas-707: 247.4;U-266/70: 274.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003509, CAB073419" Enhanced NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 29: U-266 - Adaptive immune response" "Cluster 55: Plasma cells - Humoral immune response" "CAB073419: , HPA003509: AB_1858531" "unprognostic (1.82e-1)" "unprognostic (3.20e-2)" "unprognostic (1.55e-3)" "prognostic favorable (2.87e-4)" "unprognostic (3.41e-1)" "unprognostic (7.93e-3)" "prognostic unfavorable (6.90e-5)" "unprognostic (1.19e-1)" "unprognostic (9.36e-2)" "prognostic favorable (7.43e-4)" "unprognostic (1.74e-1)" "unprognostic (9.33e-2)" "prognostic unfavorable (1.11e-4)" "unprognostic (5.11e-2)" "unprognostic (2.83e-1)" "unprognostic (3.87e-2)" "unprognostic (9.38e-2)" 25.9 23.2 14.9 52.3 15.9 119.3 31.4 16.8 18.8 33.3 15.0 48.9 55.0 27.8 28.6 23.2 20.9 26.6 14.7 15.2 16.5 22.0 26.9 29.9 90.5 16.9 17.8 23.7 32.0 21.8 12.9 33.3 17.1 42.3 49.6 19.4 44.7 21.2 12.0 14.3 45.9 30.2 16.9 43.7 49.1 24.6 16.2 57.8 31.9 15.6 97.1 36.7 14.5 18.3 38.8 13.4 36.3 46.5 37.0 47.8 0.2 60.4 53.4 36.7 40.0 21.9 23.7 294.1 32.9 63.0 30.6 15.3 23.9 35.1 59.4 41.6 37.0 53.6 16.1 36.0 98.2 68.2 33.4 36.7 34.4 30.8 52.1 48.9 83.1 34.7 43.9 247.4 43.4 23.8 28.5 52.1 12.5 27.3 19.0 110.1 46.5 143.6 46.2 26.9 18.3 36.7 25.6 55.7 56.9 52.2 22.0 149.3 56.1 20.2 19.1 36.3 47.0 274.1 146.1 80.0 40.3 48.3 34.4 24.6 13.5 24.7 6.2 22.0 7.2 37.5 8.2 7.6 12.4 29.6 7.6 7.0 30.7 12.8 37.4 45.5 13.0 13.3 14.9 15.9 16.8 18.8 15.2 16.5 16.9 17.8 17.1 16.9 16.2 18.3 65.3 16.0 33.9 18.6 185.6 24.9 60.0 39.1 31.3 34.6 39.5 29.5 9.7 30.0 38.5 20.2 29.2 89.7 136.8 71.0 50.9 60.5 498.7 35.6 50.3 104.6 77.3 34.7 26.9 101.4 91.8 60.0 72.9 50.2 25.3 27.1 99.2 45.5 75.8 23.5 28.9 80.3 42.7 107.7 53.0 1426.6 54.7 105.5 72.9 23.4 65.4 18.6 30.9 26.2 31.0 112.0 74.3 47.8 1003.3 99.5 72.4 49.2 33.4 16.0 32.9 54.3 61.1 22.5 20.5 54.4 34.7 129.4 52.3 32.6 65.0 123.7 UBE2J2 "NCUBE2, Ubc6p" ENSG00000160087 "Ubiquitin conjugating enzyme E2 J2" Q8N2K1 1 1253909-1273864 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway, Unfolded protein response" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 261.9;Late spermatids: 452.3;Spermatocytes: 261.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 34: Basophils - Unknown function" "Cluster 71: Testis - DNA repair" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 66: Spermatocytes - Spermatogenesis" "unprognostic (9.39e-2)" "unprognostic (1.17e-1)" "unprognostic (2.25e-1)" "unprognostic (3.04e-2)" "unprognostic (1.88e-2)" "unprognostic (4.46e-2)" "unprognostic (1.67e-3)" "unprognostic (1.60e-1)" "unprognostic (1.60e-2)" "unprognostic (9.57e-2)" "unprognostic (1.28e-3)" "unprognostic (1.32e-1)" "prognostic unfavorable (2.00e-4)" "unprognostic (2.09e-2)" "unprognostic (6.19e-2)" "unprognostic (1.87e-1)" "unprognostic (3.46e-2)" 31.4 36.3 23.1 24.5 23.6 22.8 29.8 26.9 26.3 30.2 22.4 36.4 23.2 33.9 12.2 44.0 32.8 16.5 37.1 23.8 22.4 35.0 45.8 30.0 25.6 24.8 23.0 29.6 35.7 20.1 35.3 19.8 23.8 32.2 15.9 14.9 30.9 15.1 50.8 39.4 34.7 19.3 22.2 44.6 37.2 105.2 23.1 23.9 29.5 21.3 22.7 30.6 29.4 27.2 70.0 30.3 40.4 39.6 31.9 32.1 31.6 50.8 44.3 73.0 53.5 54.3 50.2 37.4 52.6 50.4 40.0 49.6 42.6 55.0 57.5 64.5 68.8 58.2 64.3 47.9 62.9 56.1 50.6 31.1 30.1 58.1 42.2 39.6 53.3 52.1 80.0 38.7 43.2 38.1 82.4 63.8 45.3 47.3 67.7 74.3 40.8 63.8 37.9 25.3 140.9 73.9 38.5 80.4 89.8 36.9 42.9 62.2 36.5 44.8 40.9 53.0 56.2 79.2 88.9 114.3 58.9 83.5 36.8 83.4 36.5 69.3 33.7 37.0 31.3 37.1 35.4 35.3 36.1 32.5 32.7 32.5 54.0 39.7 38.7 34.5 42.4 29.5 23.1 23.6 26.9 26.3 23.8 22.4 24.8 23.0 23.8 22.2 23.1 27.2 32.8 9.6 17.3 18.9 34.0 42.7 51.7 71.4 23.9 31.3 28.5 29.5 18.9 32.9 40.8 29.5 8.4 71.7 53.3 44.0 56.7 70.9 261.9 25.3 28.5 34.3 17.5 45.6 12.8 93.2 71.5 34.5 33.1 25.3 16.5 32.6 31.8 30.3 52.1 23.5 14.3 35.6 54.9 31.1 41.2 452.3 37.6 31.7 40.9 12.2 44.3 33.2 70.0 8.5 16.4 105.4 33.8 37.6 50.9 76.6 54.4 73.2 23.4 29.9 32.9 29.8 40.1 261.0 100.6 38.3 43.8 87.3 35.7 40.6 40.7 61.8 UBE2K "HIP2, HYPG, UBC1" ENSG00000078140 "Ubiquitin conjugating enzyme E2 K" P61086 4 39698109-39782792 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA028869, CAB033212, CAB033515" Supported Approved "Plasma membrane,Cytosol" NA NA 390000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Cytosol "Plasma membrane" "CAB033212: AB_2272506, CAB033515: AB_2304024, HPA028869: AB_10602487" "unprognostic (1.14e-2)" "unprognostic (6.02e-2)" "unprognostic (2.42e-3)" "unprognostic (3.06e-1)" "unprognostic (6.81e-2)" "unprognostic (2.05e-1)" "unprognostic (5.05e-3)" "unprognostic (1.44e-2)" "unprognostic (2.71e-3)" "unprognostic (1.01e-1)" "prognostic unfavorable (8.60e-4)" "unprognostic (1.08e-1)" "unprognostic (3.67e-1)" "unprognostic (4.83e-2)" "unprognostic (6.88e-2)" "unprognostic (1.22e-1)" "unprognostic (4.10e-3)" 29.9 19.4 13.5 23.4 17.5 21.4 21.7 20.9 24.5 16.0 9.2 35.8 31.2 17.8 17.7 26.2 12.7 12.9 18.4 18.3 14.9 26.7 45.4 16.4 20.1 12.9 14.0 13.6 13.2 20.4 15.8 24.4 13.1 19.8 24.2 21.0 16.9 14.9 37.3 22.6 24.8 17.2 7.8 18.0 31.8 16.5 14.2 22.4 23.8 25.6 18.0 20.2 17.2 16.0 91.3 90.7 49.3 45.6 29.8 28.7 82.8 122.8 26.4 32.8 34.0 138.0 91.1 114.3 105.2 35.0 79.8 39.0 95.4 54.7 51.9 76.1 70.0 145.7 88.9 121.6 38.4 159.0 79.6 27.1 60.2 46.0 49.0 35.2 43.3 49.3 152.9 39.6 33.9 86.6 111.5 89.9 67.7 54.4 69.8 66.3 144.0 44.2 46.0 123.9 103.9 47.4 91.7 34.5 58.9 54.1 44.4 58.2 116.9 49.9 105.7 60.0 114.5 55.3 174.0 121.4 26.9 101.4 59.5 19.6 18.1 24.8 14.4 16.9 13.4 20.7 15.0 13.8 19.7 14.7 11.2 12.6 15.1 14.0 25.4 27.6 16.0 10.5 13.5 17.5 20.9 24.5 18.3 14.9 12.9 14.0 13.1 7.8 14.2 16.0 63.2 57.7 63.1 69.2 53.0 122.9 65.5 74.3 59.7 62.2 65.3 52.5 72.3 52.9 66.7 49.7 29.2 84.5 76.5 143.7 66.5 83.5 144.9 72.0 82.3 65.6 59.7 85.8 115.9 89.4 168.7 59.2 68.3 90.9 34.8 40.1 63.5 113.6 80.2 104.3 113.8 74.5 65.1 77.1 91.8 202.4 65.3 76.5 56.9 89.0 104.0 87.1 56.7 87.0 118.2 139.6 94.3 56.4 55.5 111.4 75.3 98.0 60.7 42.9 39.5 61.8 121.1 145.2 55.1 74.3 137.9 147.5 61.3 54.8 74.1 107.0 UBE2L3 UBCH7 ENSG00000185651 "Ubiquitin conjugating enzyme E2 L3" P68036 22 21549447-21624034 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Transcription, Transcription regulation, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "K-562: 544.4" "HPA045609, HPA062415" Approved Approved Nucleoplasm,Cytosol NA NA 5800000 "Cluster 31: Non-specific - Inflammatory response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 1: K-562 - Erythropoiesis" "Cluster 16: Pancreatic endocrine cells - Mixed function" "Nucleoplasm, Cytosol" "HPA045609: AB_10961322, HPA062415: AB_2684756" "unprognostic (4.90e-2)" "unprognostic (3.05e-1)" "unprognostic (1.92e-2)" "unprognostic (1.07e-2)" "unprognostic (2.74e-2)" "unprognostic (9.99e-3)" "prognostic unfavorable (1.29e-4)" "unprognostic (3.28e-2)" "unprognostic (3.65e-2)" "prognostic favorable (3.82e-6)" "unprognostic (3.53e-2)" "unprognostic (4.55e-2)" "unprognostic (3.18e-2)" "unprognostic (4.66e-2)" "unprognostic (5.09e-2)" "unprognostic (2.77e-1)" "unprognostic (3.15e-3)" 41.5 46.0 63.7 37.1 64.8 54.4 33.9 65.0 72.0 35.5 54.4 45.5 39.6 35.0 41.0 49.1 38.5 34.0 51.5 65.4 65.3 40.1 40.9 33.9 48.8 67.8 64.7 33.9 30.3 43.2 31.2 42.7 66.8 39.1 45.6 28.1 33.9 36.8 63.5 36.2 40.7 48.6 62.3 37.6 37.5 28.5 66.7 51.9 36.4 53.1 52.5 46.8 32.3 65.5 121.9 68.9 98.3 77.4 105.1 93.1 56.6 100.0 113.6 125.8 118.7 79.0 57.0 114.2 49.0 133.5 94.7 101.4 132.1 108.6 124.3 114.4 142.9 132.1 63.3 94.8 70.0 190.9 91.0 82.7 93.1 91.2 65.7 90.6 143.4 69.4 544.4 59.3 137.9 89.6 100.0 137.6 72.8 134.8 71.6 80.5 147.6 31.2 118.8 96.2 88.0 65.4 79.9 99.1 95.6 89.4 61.7 104.0 103.8 88.6 113.5 75.5 103.6 57.3 99.7 103.7 120.0 87.5 86.0 84.4 87.8 105.7 84.9 102.2 79.7 77.3 79.9 91.6 109.2 73.6 69.0 82.9 73.2 81.2 89.0 106.3 106.1 141.1 63.7 64.8 65.0 72.0 65.4 65.3 67.8 64.7 66.8 62.3 66.7 65.5 102.6 109.0 83.9 26.1 110.7 125.5 171.6 318.5 51.2 54.5 76.9 72.8 64.9 101.5 180.3 71.7 16.7 312.1 159.0 215.1 197.6 288.2 79.9 133.1 104.6 125.9 126.0 173.0 25.6 385.0 406.5 102.6 60.1 124.9 129.3 79.3 109.6 159.8 298.5 69.0 24.3 153.1 193.3 126.9 159.7 61.1 87.3 140.9 126.3 19.7 257.9 98.4 200.8 22.6 30.4 432.1 222.1 103.8 98.4 186.7 213.5 257.2 173.9 45.5 105.2 81.0 205.4 202.8 121.2 87.6 129.7 372.1 130.1 133.7 154.0 208.4 UBE2L5 UBE2L5P ENSG00000236444 "Ubiquitin conjugating enzyme E2 L5" A0A1B0GUS4 13 30422488-30429758 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" "Ligase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enriched" "Detected in single" 55 "testis: 46.5" "Not detected" "Not detected" "Low cancer specificity" "Detected in single" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "HPA045609, HPA062415" Approved Uncertain Nucleoplasm,Cytosol NA NA "Cluster 12: Non-specific - Basic cellular processes" "Cluster 83: Testis - Spermatogenesis" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Nucleoplasm, Cytosol" "HPA045609: AB_10961322, HPA062415: AB_2684756" "unprognostic (2.09e-1)" "unprognostic (1.18e-2)" "unprognostic (8.01e-3)" "unprognostic (6.41e-4)" "unprognostic (1.78e-1)" "unprognostic (7.13e-2)" "unprognostic (2.20e-1)" "unprognostic (1.65e-1)" "unprognostic (1.19e-1)" "unprognostic (6.49e-3)" "unprognostic (1.78e-1)" "unprognostic (8.00e-2)" "unprognostic (3.50e-2)" "unprognostic (9.37e-2)" "unprognostic (2.60e-1)" "unprognostic (2.44e-2)" "unprognostic (8.75e-2)" 0.5 0.2 0.2 0.2 0.1 0.3 0.4 0.4 0.4 0.4 0.0 0.3 0.2 0.8 0.2 0.2 0.5 0.1 0.2 0.2 0.0 0.1 0.2 0.2 0.3 0.0 0.0 0.2 0.2 0.0 0.2 0.1 0.0 0.4 0.1 0.2 0.2 0.2 0.4 0.7 0.2 0.4 0.0 0.2 0.2 46.5 0.0 0.2 0.2 0.0 0.2 0.3 0.3 0.1 0.1 0.0 0.1 0.2 0.1 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.7 0.2 0.0 0.2 0.2 0.1 0.1 0.1 0.1 0.1 0.1 0.0 0.2 0.0 0.0 0.1 0.2 0.0 0.0 0.1 0.0 0.2 0.2 0.2 0.1 0.1 0.0 0.0 0.4 0.5 0.2 0.0 0.0 0.1 0.1 0.0 0.1 0.2 0.1 0.0 0.1 0.0 0.3 0.1 0.1 0.5 0.0 0.1 0.1 0.1 0.1 0.2 0.0 0.3 0.1 0.2 0.0 0.4 0.2 0.3 0.2 0.7 0.2 0.6 0.2 0.3 0.3 0.4 0.2 0.3 0.4 0.4 0.3 0.3 0.4 0.7 0.2 0.1 0.4 0.4 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.8 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.7 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 UBE2L6 UBCH8 ENSG00000156587 "Ubiquitin conjugating enzyme E2 L6" O14933 11 57551656-57568284 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Hofbauer cells: 165.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003328, CAB073407" Enhanced Approved Cytosol NA NA 15000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 63: NK-cells & T-cells - Immune response" Cytosol "CAB073407: , HPA003328: AB_1858539" "prognostic favorable (6.75e-4)" "unprognostic (2.10e-2)" "unprognostic (1.09e-2)" "unprognostic (2.93e-2)" "unprognostic (1.72e-1)" "unprognostic (1.18e-1)" "unprognostic (3.13e-2)" "unprognostic (4.74e-2)" "unprognostic (1.36e-2)" "unprognostic (1.37e-3)" "prognostic unfavorable (4.88e-4)" "unprognostic (3.07e-2)" "unprognostic (1.02e-2)" "unprognostic (1.28e-1)" "unprognostic (4.17e-2)" "unprognostic (1.88e-2)" "unprognostic (6.42e-2)" 70.7 60.4 84.4 92.3 84.8 85.5 51.1 80.0 95.2 54.2 70.7 46.3 47.6 44.1 68.5 42.7 66.1 66.6 35.2 80.2 88.0 51.5 121.1 91.1 119.9 93.6 88.1 61.5 24.3 39.9 36.8 53.1 86.2 47.0 43.6 23.6 103.3 49.2 14.3 36.1 57.6 67.3 96.2 126.4 55.6 17.1 94.6 113.4 37.4 29.3 86.7 76.0 44.4 86.1 55.6 26.2 85.8 29.0 179.2 222.3 9.7 30.2 178.8 261.3 337.0 9.8 140.9 169.3 110.3 92.5 223.3 43.7 38.0 99.4 55.4 163.9 1.5 169.2 0.0 38.0 330.7 38.8 54.3 238.9 22.9 122.8 33.6 96.2 83.9 173.2 7.9 118.5 47.8 67.6 280.1 92.2 23.3 0.5 33.3 243.1 52.9 118.4 71.0 58.5 2.1 45.2 60.3 5.4 139.9 15.3 68.3 20.3 30.9 56.3 19.6 43.6 10.2 162.1 176.6 3.4 161.0 98.8 12.3 508.1 534.8 487.8 359.2 638.4 394.1 379.2 368.2 377.9 401.3 310.9 315.1 331.1 838.8 486.9 556.7 256.3 513.7 1060.5 84.4 84.8 80.0 95.2 80.2 88.0 93.6 88.1 86.2 96.2 94.6 86.1 94.6 28.9 22.2 2.9 53.5 23.3 26.2 75.7 26.2 12.4 31.9 38.7 6.0 24.3 38.2 12.9 4.2 4.2 59.3 16.4 64.6 95.4 4.9 16.6 83.4 65.5 23.9 53.0 2.0 65.2 38.1 43.8 23.0 16.4 53.9 41.3 53.2 35.3 165.3 13.5 4.8 38.6 48.8 77.4 36.9 10.9 48.1 73.1 8.8 9.4 79.0 54.0 97.9 3.5 2.0 37.3 48.1 33.4 51.4 52.8 47.7 32.3 33.3 4.4 26.3 15.4 33.8 2.4 9.8 25.6 27.7 3.4 68.8 26.9 22.7 33.3 UBE2M "hUbc12, UBC12" ENSG00000130725 "Ubiquitin conjugating enzyme E2 M" P61081 19 58555712-58558954 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HEK 293: 1197.4" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004993, HPA054551, HPA057800" Approved Enhanced "Nucleoplasm,Nucleoli,Nuclear bodies,Cytosol" Yes No 49000 "Cluster 50: Neutrophils - Cellular senescence" "Cluster 39: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 7: Non-specific - Mitochondria" Nucleoplasm "Nucleoli, Nuclear bodies, Cytosol" "CAB004993: AB_436983, HPA054551: AB_2682520, HPA057800: AB_2683531" "unprognostic (1.42e-1)" "unprognostic (1.99e-1)" "unprognostic (1.63e-2)" "unprognostic (1.39e-1)" "unprognostic (8.35e-2)" "unprognostic (1.77e-1)" "unprognostic (1.17e-3)" "unprognostic (3.90e-3)" "unprognostic (4.86e-2)" "unprognostic (1.09e-2)" "unprognostic (3.05e-3)" "unprognostic (1.96e-1)" "unprognostic (1.81e-1)" "unprognostic (8.63e-3)" "unprognostic (1.76e-1)" "unprognostic (5.85e-2)" "unprognostic (8.42e-3)" 46.3 66.1 133.2 39.2 138.8 82.2 42.8 116.7 199.7 48.9 104.0 72.5 41.7 48.1 36.3 61.8 51.3 30.9 111.0 141.2 129.3 63.2 45.6 46.3 43.4 123.5 124.4 46.0 47.5 84.5 69.7 45.0 127.7 48.3 32.5 49.7 48.5 46.1 174.0 56.6 41.6 39.5 111.9 49.3 55.8 81.0 124.4 51.7 44.3 104.5 43.7 58.3 45.8 139.1 161.8 272.1 119.3 124.8 61.7 71.9 112.2 166.0 117.4 97.8 82.8 162.7 109.7 161.9 135.5 93.4 198.1 105.9 130.1 138.6 69.2 207.3 1197.4 235.5 163.7 113.7 154.4 197.3 192.9 82.1 107.1 145.9 167.3 102.6 117.8 146.3 119.6 179.4 127.3 158.2 177.2 223.7 87.1 155.1 306.5 171.7 106.7 204.5 111.6 166.8 239.5 205.5 133.1 149.7 163.3 41.6 94.4 188.4 105.2 333.4 80.5 110.6 281.3 262.3 411.9 169.6 206.0 177.6 220.5 6.7 3.6 4.2 3.0 2.6 2.2 2.8 3.2 3.2 2.8 3.8 3.3 2.2 10.1 1.7 2.7 6.7 2.9 1.9 133.2 138.8 116.7 199.7 141.2 129.3 123.5 124.4 127.7 111.9 124.4 139.1 75.1 6.4 13.0 14.7 32.7 40.4 36.3 15.9 6.2 100.0 74.5 81.3 38.5 20.0 11.6 18.4 20.9 21.0 72.9 63.9 7.9 17.3 25.7 89.6 68.0 40.1 41.2 39.8 22.9 30.6 22.4 38.9 21.9 63.3 19.7 103.3 28.5 38.0 35.4 109.4 20.8 43.8 20.3 27.0 33.5 34.0 17.4 42.5 35.6 15.9 21.1 142.3 14.4 8.5 17.9 41.8 21.4 13.9 35.4 59.1 37.9 33.9 18.6 81.1 26.3 41.5 55.4 27.1 7.9 17.0 56.8 52.5 41.0 156.1 41.6 56.2 UBE2N "MGC8489, UBC13, UbcH-ben" ENSG00000177889 "Ubiquitin conjugating enzyme E2 N" P61088 12 93405673-93441947 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 15 "Early spermatids: 2532.0;Late spermatids: 8141.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA044976 Enhanced Supported "Nucleoplasm,Nucleoli fibrillar center" NA NA 1800000 "Cluster 12: Non-specific - Basic cellular processes" "Cluster 23: Testis - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 25: Spermatids - Spermatogenesis" Nucleoplasm "Nucleoli fibrillar center" "HPA044976: AB_2679163" "unprognostic (1.74e-2)" "unprognostic (5.53e-1)" "unprognostic (1.26e-2)" "unprognostic (2.30e-1)" "unprognostic (1.07e-1)" "unprognostic (8.09e-2)" "prognostic unfavorable (2.41e-4)" "unprognostic (8.49e-3)" "unprognostic (2.72e-1)" "unprognostic (4.28e-3)" "unprognostic (1.07e-1)" "unprognostic (9.28e-2)" "unprognostic (1.03e-1)" "unprognostic (3.31e-2)" "unprognostic (1.29e-1)" "unprognostic (1.48e-1)" "unprognostic (1.30e-3)" 52.4 48.6 46.4 62.1 49.9 69.9 41.6 40.3 51.6 35.8 26.8 55.9 42.5 44.0 38.3 60.4 37.3 33.5 57.6 50.8 53.2 54.4 45.5 38.2 80.0 45.2 43.9 31.3 30.6 40.4 32.6 49.5 52.2 46.0 44.0 50.3 36.0 34.5 83.0 41.3 42.3 42.7 44.3 42.9 41.0 186.9 44.3 79.4 29.0 70.3 73.8 76.4 38.6 44.4 190.3 133.2 221.1 142.6 82.9 81.4 154.5 259.4 135.6 201.0 167.3 239.8 80.0 380.2 57.3 151.1 133.8 147.7 245.2 188.7 189.7 323.3 128.4 258.0 66.6 214.2 106.4 311.9 165.1 86.3 75.2 120.8 148.9 143.1 157.3 146.9 292.8 58.0 210.9 155.3 310.4 286.2 288.9 165.9 189.4 237.3 179.9 186.6 170.1 280.9 214.9 195.6 136.1 158.5 130.0 118.7 207.5 188.0 165.8 135.7 114.6 124.1 189.9 99.5 289.4 324.0 53.5 162.5 170.2 133.7 89.5 101.3 99.3 123.3 116.8 174.0 124.8 124.1 119.6 144.7 109.3 104.9 27.7 106.0 141.7 89.6 198.6 202.5 46.4 49.9 40.3 51.6 50.8 53.2 45.2 43.9 52.2 44.3 44.3 44.4 87.5 38.5 45.8 24.8 151.4 322.2 231.3 219.1 92.2 72.1 84.3 60.5 74.6 60.1 112.2 90.1 27.1 236.0 104.3 76.3 191.7 141.4 2532.0 79.7 79.0 95.3 74.7 75.9 44.6 99.0 226.0 100.9 49.5 96.5 93.8 68.3 55.3 55.3 165.6 87.5 49.0 78.6 187.2 67.8 216.3 8141.3 93.8 97.0 147.7 33.7 152.9 111.9 79.3 38.7 42.1 135.5 83.8 86.1 113.3 218.2 61.2 171.3 88.9 57.6 46.0 101.9 146.2 338.4 227.6 142.2 322.5 284.7 128.2 86.4 94.9 260.3 UBE2O E2-230K ENSG00000175931 "Ubiquitin conjugating enzyme E2 O" Q9C0C9 17 76389456-76453152 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Transport, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 54.7;Inhibitory neurons: 63.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA023605 Uncertain Supported "Nucleoplasm,Nuclear bodies" No No 220000 "Cluster 21: B-cells - Adaptive immune response" "Cluster 39: Non-specific - Mitochondria" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 62: Horizontal cells - Visual perception" "Nuclear bodies" Nucleoplasm "HPA023605: AB_2671257" "unprognostic (8.75e-2)" "unprognostic (2.04e-1)" "unprognostic (7.44e-2)" "unprognostic (8.68e-2)" "unprognostic (1.17e-1)" "unprognostic (3.22e-2)" "prognostic unfavorable (6.84e-8)" "unprognostic (3.54e-1)" "unprognostic (2.68e-1)" "unprognostic (7.61e-2)" "unprognostic (1.32e-3)" "unprognostic (1.18e-2)" "prognostic unfavorable (4.34e-9)" "unprognostic (7.22e-2)" "unprognostic (9.64e-2)" "unprognostic (9.12e-2)" "unprognostic (2.07e-1)" 9.1 9.7 12.9 10.1 14.0 21.2 9.7 8.0 24.9 12.8 1.4 10.7 9.4 11.5 7.0 12.8 11.0 6.5 20.3 15.4 11.7 8.4 10.5 8.7 13.1 21.7 9.0 15.1 17.4 10.9 18.2 9.1 21.7 11.6 5.3 10.5 12.9 8.7 28.3 16.1 10.6 7.1 4.4 13.9 11.0 16.6 11.6 12.0 16.1 13.4 8.6 10.8 12.5 14.5 25.8 29.2 29.1 35.5 17.7 11.3 25.2 11.8 12.8 18.9 18.3 25.6 12.7 36.4 8.3 14.8 29.7 25.2 34.2 20.4 13.2 10.5 42.2 36.9 20.6 42.9 14.7 22.6 22.0 11.4 16.2 18.1 15.3 16.2 25.7 19.9 31.5 31.4 9.6 21.3 44.7 26.0 27.0 15.5 38.9 43.3 37.6 40.2 8.5 22.1 43.0 38.5 17.4 43.9 23.6 26.3 25.4 16.1 15.4 21.9 20.5 18.8 19.9 25.8 9.2 30.8 24.1 18.8 14.6 0.0 0.7 1.0 1.4 0.3 0.8 0.9 0.9 0.7 0.4 1.6 0.7 1.1 0.1 0.5 0.4 1.5 0.9 0.8 12.9 14.0 8.0 24.9 15.4 11.7 21.7 9.0 21.7 4.4 11.6 14.5 7.9 3.2 7.7 24.8 19.6 8.7 6.1 7.2 13.1 45.8 9.7 9.1 23.2 5.7 7.3 7.3 41.7 6.4 15.2 6.5 0.0 6.0 1.8 8.6 13.7 8.3 23.4 33.2 54.7 9.4 7.4 8.3 17.9 10.1 7.0 18.9 7.1 8.5 8.1 45.4 63.0 9.3 2.0 5.3 11.0 1.8 9.6 11.6 5.4 19.7 10.0 7.3 18.6 27.2 24.7 7.2 5.7 7.9 22.9 9.8 5.2 3.3 5.6 23.8 6.6 12.2 10.9 19.6 23.2 12.9 12.4 5.2 14.7 13.3 8.7 6.2 UBE2Q1 "NICE-5, PRO3094, UBE2Q" ENSG00000160714 "Ubiquitin conjugating enzyme E2 Q1" Q7Z7E8 1 154548577-154559028 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA063368 Approved Approved Nucleoplasm,Centrosome,Cytosol No No "Cluster 15: NK-cells - Transcription" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 43: THP-1 - Innate immune response" "Cluster 10: Non-specific - Unknown function" Nucleoplasm "Centrosome, Cytosol" "HPA063368: AB_2684996" "unprognostic (3.88e-1)" "unprognostic (2.13e-1)" "unprognostic (4.44e-3)" "unprognostic (3.64e-3)" "unprognostic (5.32e-3)" "unprognostic (6.10e-3)" "prognostic unfavorable (8.74e-4)" "unprognostic (2.92e-1)" "unprognostic (2.07e-1)" "unprognostic (9.92e-3)" "unprognostic (3.79e-2)" "unprognostic (1.46e-1)" "prognostic unfavorable (4.84e-7)" "unprognostic (2.20e-1)" "unprognostic (4.46e-1)" "prognostic favorable (1.86e-5)" "unprognostic (1.04e-2)" 25.4 23.1 36.1 19.0 37.0 32.2 22.4 34.5 43.3 21.2 35.2 24.3 18.7 21.8 27.2 27.4 23.7 19.9 25.9 37.3 38.0 28.8 31.6 25.0 29.5 36.0 36.0 23.1 31.8 28.3 31.3 23.9 37.5 21.2 28.2 25.9 22.5 20.9 26.3 26.7 25.5 24.4 35.5 32.3 26.8 34.6 38.2 29.8 23.0 25.8 35.2 25.7 22.2 36.2 39.0 33.0 45.6 35.0 45.8 46.9 39.4 38.0 57.0 47.3 38.0 37.3 40.4 47.5 53.3 52.8 39.5 33.0 54.3 43.6 40.5 48.7 34.3 37.8 29.6 36.4 57.5 62.1 58.3 45.5 56.7 38.5 44.1 51.3 61.8 43.3 32.4 57.1 61.3 60.4 38.1 45.6 62.5 92.3 55.5 43.4 31.8 50.3 52.4 40.6 46.2 64.6 38.1 70.6 64.5 77.5 43.3 93.2 43.3 30.5 34.1 36.5 41.2 69.3 55.2 62.1 34.2 43.2 47.1 3.9 1.3 2.9 2.1 1.6 2.0 1.4 2.0 2.7 1.2 1.5 2.2 2.5 2.0 2.3 1.3 2.4 3.1 0.8 36.1 37.0 34.5 43.3 37.3 38.0 36.0 36.0 37.5 35.5 38.2 36.2 40.8 32.1 26.5 9.8 24.7 16.2 18.0 15.9 15.4 41.2 27.3 32.5 29.4 27.1 18.4 16.5 4.2 19.8 45.2 33.4 11.7 14.5 4.5 24.8 20.9 32.8 33.6 12.0 12.2 21.0 18.2 23.3 14.3 24.9 10.8 31.9 35.3 38.3 27.5 60.6 11.7 29.2 22.4 48.0 19.7 7.3 17.7 27.9 14.2 10.3 30.9 42.8 39.1 7.1 11.7 26.2 18.5 19.2 22.1 29.5 29.6 19.7 29.0 23.1 13.1 20.1 21.2 34.1 29.2 18.1 19.0 19.6 26.5 36.3 25.7 31.4 UBE2Q2 DKFZp762C143 ENSG00000140367 "Ubiquitin conjugating enzyme E2 Q2" Q8WVN8 15 75843307-75901078 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Rod photoreceptor cells: 160.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 9: Photoreceptor cells - Phototransduction" "unprognostic (1.28e-1)" "unprognostic (1.66e-2)" "unprognostic (2.45e-2)" "unprognostic (4.28e-2)" "unprognostic (8.82e-2)" "unprognostic (1.13e-1)" "unprognostic (1.07e-3)" "unprognostic (1.32e-1)" "unprognostic (6.38e-2)" "prognostic favorable (5.73e-4)" "unprognostic (1.67e-1)" "unprognostic (1.87e-1)" "unprognostic (1.47e-3)" "unprognostic (1.01e-3)" "unprognostic (1.92e-1)" "unprognostic (1.69e-2)" "unprognostic (5.92e-2)" 24.3 26.7 18.3 16.7 19.3 40.2 24.4 20.0 28.9 25.5 15.0 37.2 9.3 24.9 18.8 22.5 17.4 22.3 29.5 18.3 21.9 22.5 7.2 19.2 18.6 21.8 22.7 22.8 19.4 17.4 16.1 29.0 22.4 30.4 19.8 39.0 25.4 20.9 23.0 16.5 15.7 30.5 22.9 21.7 19.5 21.1 19.9 21.0 31.8 16.9 17.7 27.1 17.0 24.4 23.0 35.5 30.0 22.6 42.8 56.7 47.2 50.4 57.2 32.8 37.1 18.7 30.7 22.7 36.2 73.5 27.8 18.1 58.5 33.5 39.9 24.1 23.7 28.5 20.1 24.5 48.1 28.9 15.7 40.7 37.4 23.1 33.4 46.3 46.2 40.5 11.3 33.2 70.1 18.0 24.7 27.6 22.4 3.5 25.3 29.5 47.2 9.4 51.8 36.8 27.4 21.6 42.4 39.6 55.6 42.3 25.6 40.3 60.7 40.2 36.1 27.3 17.8 36.3 68.1 17.6 15.9 44.9 25.2 31.3 6.3 21.3 9.0 7.3 11.2 8.1 11.8 9.7 5.7 7.8 9.4 7.9 0.9 14.6 10.0 2.1 8.4 6.4 18.3 19.3 20.0 28.9 18.3 21.9 21.8 22.7 22.4 22.9 19.9 24.4 54.3 3.2 6.5 17.6 29.0 50.3 27.7 12.9 33.6 30.3 39.3 26.0 32.1 18.6 17.4 23.9 135.5 55.0 42.6 9.4 23.5 23.8 95.7 18.3 47.4 40.7 18.6 19.1 15.2 16.9 126.2 38.2 12.2 28.9 20.3 27.8 36.4 4.7 23.0 6.7 22.6 30.0 26.4 25.9 51.8 36.7 24.2 34.0 37.4 17.8 30.6 20.2 68.0 30.7 29.5 22.5 10.7 29.0 43.3 58.4 1.3 39.6 9.3 160.8 26.3 28.9 42.9 64.8 64.4 34.4 46.5 110.0 36.1 28.3 17.7 38.7 UBE2QL1 FLJ25076 ENSG00000215218 "Ubiquitin conjugating enzyme E2 Q family like 1" A1L167 5 6448859-6496723 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 5 "brain: 26.1;heart muscle: 16.8;retina: 28.3;skeletal muscle: 54.5;tongue: 13.9" "Cell type enhanced" "Detected in many" "Bipolar cells: 30.0;Cardiomyocytes: 27.6;Excitatory neurons: 47.8;Granulosa cells: 45.5;Horizontal cells: 45.4;Inhibitory neurons: 35.3;Rod photoreceptor cells: 63.6" "Cancer enhanced" "Detected in many" "thyroid cancer: 5.4" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "Karpas-707: 29.7;PC-3: 24.6;SCLC-21H: 23.1;U-266/70: 54.4;U-266/84: 52.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA057414 Supported "Nucleoplasm,Plasma membrane" NA NA "Cluster 54: Non-specific - Microtubule organization" "Cluster 29: U-266 - Adaptive immune response" "Cluster 46: Photoreceptor cells - Phototransduction" Nucleoplasm "Plasma membrane" "HPA057414: " "unprognostic (1.45e-2)" "unprognostic (1.58e-2)" "unprognostic (1.79e-2)" "unprognostic (2.10e-1)" "unprognostic (1.08e-2)" "unprognostic (7.43e-2)" "unprognostic (1.15e-2)" "unprognostic (1.36e-1)" "unprognostic (3.10e-1)" "unprognostic (7.16e-2)" "unprognostic (2.15e-3)" "unprognostic (8.41e-2)" "prognostic favorable (6.81e-8)" "unprognostic (3.18e-3)" "unprognostic (2.81e-1)" "unprognostic (1.27e-2)" "unprognostic (1.41e-2)" 1.2 1.4 14.3 0.4 14.6 0.0 1.1 16.5 26.1 2.1 1.8 5.3 0.3 0.8 1.0 0.4 0.7 0.4 16.8 17.9 11.4 3.4 1.2 0.1 0.1 12.0 7.9 2.6 0.6 0.1 3.2 0.0 11.6 3.5 0.3 28.3 0.8 5.5 54.5 1.5 1.4 0.7 5.6 0.2 2.9 0.7 10.1 0.3 1.2 13.9 0.2 0.3 1.3 17.7 0.1 0.0 0.0 0.3 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 29.7 0.0 5.3 0.0 0.0 0.3 0.0 24.6 0.1 0.0 11.5 0.0 0.0 23.1 4.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 54.4 52.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.3 14.6 16.5 26.1 17.9 11.4 12.0 7.9 11.6 5.6 10.1 17.7 0.2 0.0 0.0 5.5 0.3 1.3 0.5 0.5 0.0 30.0 0.4 1.0 27.6 0.0 0.0 0.0 6.2 0.0 0.0 0.0 5.9 0.0 0.0 0.2 0.4 1.0 5.4 0.0 47.8 0.2 0.0 3.6 1.1 0.1 0.0 45.5 0.0 1.0 0.1 45.4 35.3 0.0 0.0 0.3 0.3 0.3 4.1 0.1 0.0 2.8 0.0 9.4 0.0 12.1 5.4 0.1 0.0 6.8 1.8 0.9 0.0 0.2 0.0 63.6 0.0 3.2 1.4 0.1 0.3 0.0 0.1 0.0 0.0 0.5 0.0 0.0 UBE2R2 "CDC34B, FLJ20419, MGC10481, UBC3B" ENSG00000107341 "Ubiquitin conjugating enzyme E2 R2" Q712K3 9 33817160-33920399 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 311.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA061000, HPA074334" Approved Nucleoplasm,Nucleoli,Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 59: Non-specific - Translation" "Cluster 12: NES - Nervous system development" "Cluster 34: Spermatids - Unknown function" "Nucleoplasm, Nucleoli" Cytosol "HPA061000: AB_2684408, HPA074334: " "unprognostic (1.51e-1)" "unprognostic (1.50e-1)" "unprognostic (7.08e-2)" "unprognostic (1.53e-1)" "unprognostic (6.55e-2)" "unprognostic (5.15e-2)" "prognostic unfavorable (4.37e-4)" "unprognostic (1.82e-3)" "unprognostic (4.61e-3)" "unprognostic (3.05e-3)" "unprognostic (2.22e-2)" "unprognostic (4.19e-1)" "unprognostic (2.01e-2)" "unprognostic (4.18e-2)" "unprognostic (1.22e-1)" "unprognostic (5.72e-2)" "unprognostic (1.43e-1)" 32.0 20.6 25.4 20.2 27.3 15.4 27.1 24.8 28.0 30.8 20.8 31.4 28.0 28.5 16.3 29.2 23.9 18.6 32.4 24.8 24.6 22.1 33.3 28.2 21.7 27.2 25.8 30.1 53.4 14.5 15.0 23.9 26.7 20.9 19.6 25.0 21.5 18.4 63.1 34.5 24.8 25.9 24.5 23.1 22.1 44.8 25.0 30.1 18.3 44.8 25.4 26.6 28.7 30.2 41.2 42.0 78.7 35.0 42.0 68.2 25.1 34.7 46.5 38.7 38.3 34.0 28.7 33.9 14.4 47.2 28.3 17.8 41.5 38.5 41.8 58.3 22.7 28.7 43.7 43.3 60.1 34.6 31.0 58.4 55.6 31.8 59.2 61.5 65.8 39.8 28.0 35.0 38.7 22.6 68.0 91.4 46.2 33.1 34.7 63.2 24.0 17.6 41.1 28.9 37.6 45.4 40.1 35.2 27.0 49.5 31.3 41.9 50.3 37.8 35.4 26.8 32.9 23.5 23.0 46.5 36.0 19.7 83.5 22.6 10.9 6.3 2.8 11.1 1.7 4.6 2.6 2.2 6.1 4.8 2.5 2.3 31.7 7.4 18.7 3.7 3.3 4.0 25.4 27.3 24.8 28.0 24.8 24.6 27.2 25.8 26.7 24.5 25.0 30.2 73.7 22.4 30.7 39.8 38.6 105.5 46.3 26.1 32.5 65.8 57.8 60.8 134.8 57.2 26.8 22.0 14.6 69.5 46.4 64.7 15.6 49.7 311.1 65.7 84.9 74.9 72.0 36.6 67.8 69.4 82.0 57.4 25.5 81.8 13.3 99.2 84.9 88.3 76.6 60.6 67.0 55.4 32.6 123.5 112.2 257.4 67.1 110.6 35.6 40.3 116.4 124.3 42.2 45.2 127.8 84.7 49.1 76.0 24.0 83.9 79.1 59.8 25.0 31.2 59.2 48.3 55.6 94.4 64.6 41.8 120.5 82.8 34.9 68.0 48.7 121.2 UBE2S E2-EPF ENSG00000108106 "Ubiquitin conjugating enzyme E2 S" Q16763 19 55399745-55407788 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 115.9;testis: 158.3" "Cell type enhanced" "Detected in many" "Breast myoepithelial cells: 341.4;dendritic cells: 432.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB015228, HPA057150" Approved Approved "Nucleoplasm,Plasma membrane" NA Yes "Cluster 37: B-cells - Transcription" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 7: Non-specific - Mitochondria" "Plasma membrane" Nucleoplasm "CAB015228: , HPA057150: AB_2683351" "unprognostic (2.79e-1)" "unprognostic (2.42e-1)" "unprognostic (2.57e-1)" "prognostic unfavorable (2.05e-4)" "unprognostic (9.54e-2)" "unprognostic (1.41e-1)" "prognostic unfavorable (8.00e-6)" "unprognostic (1.42e-3)" "unprognostic (2.32e-1)" "unprognostic (2.31e-1)" "unprognostic (8.08e-2)" "unprognostic (4.52e-2)" "prognostic unfavorable (8.16e-8)" "unprognostic (1.05e-1)" "unprognostic (9.51e-2)" "unprognostic (1.58e-1)" "unprognostic (1.75e-1)" 16.3 17.6 17.1 21.8 17.3 115.9 11.0 15.7 23.7 16.8 10.9 18.5 11.4 17.2 5.5 37.1 15.1 13.1 24.8 25.2 23.8 13.0 11.5 16.2 35.7 17.0 16.5 14.8 7.7 6.8 28.8 13.6 22.2 15.1 9.3 9.4 12.0 6.2 15.5 12.0 16.2 15.0 16.7 25.7 17.6 158.3 18.9 47.8 10.3 5.7 30.9 16.2 17.8 21.3 532.9 279.4 241.3 193.8 15.3 21.6 42.9 419.3 126.1 253.2 229.1 191.1 183.6 508.6 169.5 106.4 304.5 152.9 243.6 109.5 111.4 402.0 810.5 305.8 162.8 62.5 45.1 370.0 286.0 23.8 30.2 186.7 179.1 55.0 100.6 272.7 310.0 347.0 161.3 139.5 503.2 191.3 605.3 147.2 470.6 437.4 185.5 185.8 69.2 111.5 609.3 330.0 534.5 131.2 248.6 72.6 93.8 198.1 155.9 151.9 432.8 130.7 1013.5 277.1 734.4 617.0 159.2 257.5 562.7 0.5 0.8 1.3 0.7 0.6 0.5 2.5 1.0 1.0 0.6 0.6 1.0 0.5 2.4 0.2 0.4 1.3 0.4 0.1 17.1 17.3 15.7 23.7 25.2 23.8 17.0 16.5 22.2 16.7 18.9 21.3 308.0 0.0 3.4 5.9 161.3 162.6 151.2 31.5 81.4 59.3 235.9 341.4 3.1 8.6 9.9 20.2 54.2 87.8 432.7 59.2 15.6 42.8 127.5 89.3 68.2 72.5 92.6 166.5 8.7 30.5 247.9 99.3 44.9 68.0 18.4 200.9 31.8 10.6 65.5 32.0 11.0 69.1 38.7 26.8 125.3 52.2 17.4 131.7 74.7 3.7 36.7 91.1 21.6 7.5 13.5 82.3 44.1 12.4 100.6 82.9 20.4 18.4 9.7 75.7 13.1 125.2 186.7 196.9 174.0 74.1 115.9 59.8 233.3 64.6 55.8 121.1 UBE2T "FANCT, HSPC150" ENSG00000077152 "Ubiquitin conjugating enzyme E2 T" Q9NPD8 1 202331657-202341980 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Disease variant, Fanconi anemia" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "lymphoid tissue: 47.1" "Cell type enhanced" "Detected in many" "Cytotrophoblasts: 74.5;Erythroid cells: 134.3;Extravillous trophoblasts: 103.4;Spermatocytes: 114.1;Spermatogonia: 113.1" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA002831 Approved Nucleoplasm,Nucleoli NA Yes "Cluster 27: Non-specific - Gene expression" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoli Nucleoplasm "HPA002831: AB_1080445" "unprognostic (2.38e-3)" "unprognostic (6.37e-2)" "unprognostic (5.27e-2)" "unprognostic (5.19e-2)" "unprognostic (2.81e-1)" "unprognostic (6.13e-3)" "prognostic unfavorable (4.79e-6)" "unprognostic (1.71e-2)" "unprognostic (2.32e-2)" "prognostic favorable (6.90e-6)" "unprognostic (6.28e-3)" "unprognostic (2.85e-2)" "prognostic unfavorable (2.22e-16)" "unprognostic (5.37e-3)" "unprognostic (1.58e-1)" "unprognostic (1.20e-1)" "unprognostic (4.86e-2)" 2.3 3.7 6.6 10.4 6.5 28.7 4.5 5.8 13.7 4.1 5.0 13.1 8.7 4.5 4.4 10.6 3.3 2.5 11.3 6.8 7.4 3.5 3.2 3.0 19.0 6.5 6.6 1.0 0.7 4.4 3.0 10.1 6.9 2.1 15.5 2.5 2.7 3.1 17.2 5.3 8.2 9.4 6.0 6.2 4.7 19.3 6.7 47.1 2.9 13.0 18.6 6.3 5.0 6.1 123.3 111.6 167.1 79.8 15.4 27.9 94.2 130.2 72.8 146.0 102.6 79.9 147.1 140.4 50.0 47.0 108.4 98.6 154.1 76.7 131.2 128.1 87.2 85.6 54.0 93.8 6.9 105.2 102.0 9.8 18.1 114.0 47.2 34.3 85.8 157.4 111.0 114.0 116.4 113.3 190.8 135.1 65.4 126.9 57.4 145.0 176.2 122.9 57.1 58.1 131.3 132.8 90.2 112.1 44.8 49.8 117.1 64.6 41.8 65.7 104.6 116.1 159.6 57.8 120.1 182.9 64.5 107.0 139.1 0.0 0.7 1.7 3.3 2.3 2.5 8.5 4.5 3.3 1.7 6.6 6.4 7.1 0.0 1.2 8.9 3.4 10.8 2.4 6.6 6.5 5.8 13.7 6.8 7.4 6.5 6.6 6.9 6.0 6.7 6.1 1.9 0.0 2.2 1.3 13.3 14.3 10.4 29.9 2.8 6.4 6.3 8.6 12.8 0.0 12.1 5.5 0.0 74.5 5.4 10.1 5.9 10.9 24.4 15.7 7.6 5.3 1.2 134.3 8.3 7.5 103.4 11.8 10.7 6.7 8.8 32.2 3.9 2.4 27.7 10.1 6.1 14.4 32.6 1.9 5.4 8.2 3.1 5.8 3.6 1.9 2.6 1.6 0.0 1.0 1.4 10.3 2.9 4.1 32.1 5.2 3.3 12.2 16.2 1.2 6.6 0.8 11.3 114.1 113.1 15.5 10.9 22.4 9.3 12.1 30.5 11.3 UBE2U MGC35130 ENSG00000177414 "Ubiquitin conjugating enzyme E2 U" Q5VVX9 1 64203627-64267368 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 19 "testis: 44.7" "Group enriched" "Detected in some" 4 "Early spermatids: 154.3;Late spermatids: 214.5" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Region enhanced" "Detected in many" "midbrain: 8.1" NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 25: Spermatids - Spermatogenesis" "unprognostic (9.44e-4)" "unprognostic (5.52e-2)" "unprognostic (1.81e-1)" "unprognostic (2.37e-1)" "unprognostic (4.01e-2)" "unprognostic (3.63e-1)" "unprognostic (7.69e-2)" 0.0 0.0 0.2 0.0 0.2 0.0 0.0 0.2 0.5 0.0 0.9 0.0 0.0 0.2 0.7 0.0 0.0 0.0 0.1 0.2 0.2 0.4 0.0 0.0 0.1 0.2 0.2 0.0 0.3 0.3 0.0 0.1 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.2 0.0 2.4 44.7 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.2 0.5 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 1.8 0.0 0.1 0.0 0.0 0.0 1.2 154.3 0.0 0.0 0.1 0.0 0.0 0.2 0.2 2.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.0 0.0 0.0 214.5 1.8 0.1 0.0 0.0 0.6 0.0 0.0 0.5 0.5 0.8 0.0 0.7 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 40.9 2.3 0.0 0.0 0.3 0.0 0.0 0.0 0.0 UBE2W "FLJ11011, UBC-16" ENSG00000104343 "Ubiquitin conjugating enzyme E2 W" Q96B02 8 73780097-73878910 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Early spermatids: 154.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "HPA045161, HPA073181" Uncertain Approved Nucleoli NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 23: Testis - Cell cycle regulation" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoli "HPA045161: AB_10960706, HPA073181: AB_2686578" "unprognostic (5.36e-2)" "unprognostic (1.87e-1)" "unprognostic (7.52e-2)" "unprognostic (1.32e-3)" "unprognostic (3.17e-1)" "unprognostic (9.74e-2)" "unprognostic (3.09e-2)" "unprognostic (6.93e-3)" "unprognostic (1.83e-1)" "unprognostic (3.47e-1)" "unprognostic (1.33e-1)" "unprognostic (2.34e-1)" "unprognostic (5.01e-2)" "unprognostic (4.38e-2)" "unprognostic (9.31e-2)" "unprognostic (1.62e-1)" "unprognostic (1.18e-1)" 7.5 6.2 5.3 7.5 5.3 11.4 7.0 6.3 7.2 5.9 1.1 5.2 4.5 5.1 5.5 8.7 4.7 8.1 8.3 6.1 3.0 11.2 12.6 7.3 7.1 2.8 2.1 5.4 6.7 8.6 4.6 7.3 3.4 6.0 5.9 10.4 5.7 5.2 8.5 5.5 4.7 6.3 1.6 6.7 5.5 9.5 3.3 7.0 9.1 10.0 7.1 9.7 6.2 4.2 10.3 7.0 8.2 8.0 13.0 14.4 6.8 10.8 12.6 10.6 10.8 5.9 11.1 4.8 8.6 11.7 15.7 10.0 11.2 11.7 16.7 7.7 7.2 10.3 6.5 9.0 8.9 5.6 12.9 10.6 12.2 12.4 21.9 8.5 13.4 5.6 5.1 9.7 16.1 8.7 11.8 6.4 6.2 14.3 13.0 3.8 7.5 4.1 19.7 11.6 5.6 6.5 8.5 26.4 13.2 8.4 13.4 10.0 11.8 12.2 9.4 9.7 8.2 8.7 9.5 3.6 11.2 8.2 11.2 23.8 13.1 17.4 4.7 12.8 5.8 6.8 4.8 3.6 9.1 6.8 4.3 5.0 33.1 7.0 14.4 11.9 6.1 6.9 5.3 5.3 6.3 7.2 6.1 3.0 2.8 2.1 3.4 1.6 3.3 4.2 28.7 16.0 14.0 40.1 30.3 55.3 26.4 32.1 19.4 35.5 26.7 14.7 24.3 37.1 22.9 53.3 16.7 18.4 35.0 14.2 50.9 23.2 154.5 18.3 21.0 35.3 23.3 26.5 117.0 17.4 20.0 24.9 13.3 26.9 21.0 16.8 26.0 28.7 39.9 42.1 91.8 12.1 22.4 50.3 107.9 56.8 20.5 45.7 42.7 104.9 67.0 28.8 21.6 66.9 67.7 20.9 12.4 18.8 21.3 34.1 14.7 76.1 19.2 32.2 19.7 27.3 39.9 39.4 30.4 20.9 64.5 55.1 31.0 30.6 12.9 40.9 UBE2Z "FLJ13855, USE1" ENSG00000159202 "Ubiquitin conjugating enzyme E2 Z" Q9H832 17 48908407-48929056 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA007922 Approved Supported Nucleoplasm,Cytosol NA NA "Cluster 39: Non-specific - mRNA processing" "Cluster 30: Epididymis - Antimicrobial activity" "Cluster 44: HDLM-2 - Immune response" "Cluster 22: Epithelial cell types - Mixed function" "Nucleoplasm, Cytosol" "HPA007922: AB_1858551" "unprognostic (6.85e-2)" "unprognostic (5.72e-3)" "prognostic favorable (4.62e-4)" "unprognostic (9.11e-2)" "unprognostic (3.71e-3)" "unprognostic (1.76e-1)" "prognostic unfavorable (5.57e-4)" "unprognostic (2.32e-2)" "unprognostic (5.26e-2)" "unprognostic (8.66e-2)" "unprognostic (9.17e-3)" "unprognostic (3.48e-2)" "prognostic unfavorable (1.05e-4)" "unprognostic (2.63e-2)" "unprognostic (2.11e-2)" "unprognostic (1.91e-2)" "unprognostic (1.52e-1)" 33.5 45.9 37.4 37.8 40.6 33.4 36.0 37.7 44.5 41.2 32.8 37.6 34.6 39.8 60.3 45.3 44.4 34.6 33.8 40.0 40.7 40.2 33.1 34.9 44.9 39.2 37.9 36.2 34.5 46.8 31.4 42.6 42.6 39.1 40.4 38.4 38.5 47.0 29.9 43.9 35.7 49.3 35.7 41.9 35.8 28.0 40.7 45.2 50.2 28.8 59.3 45.8 39.1 57.8 101.2 122.4 45.1 43.0 111.8 107.7 61.6 107.6 131.1 126.1 120.7 153.8 84.8 81.6 150.5 133.1 158.0 64.0 57.1 100.7 159.7 271.7 61.8 73.9 80.3 96.8 128.8 53.0 76.3 92.4 109.5 103.1 132.3 134.7 94.0 38.1 55.2 103.0 137.4 160.8 57.5 52.4 42.1 122.4 105.7 45.7 114.6 46.6 98.7 97.6 46.4 70.1 73.2 38.8 76.5 100.7 107.7 41.4 111.2 187.2 89.9 62.0 89.4 77.8 79.5 47.6 91.8 38.2 83.2 5.2 7.7 5.7 8.3 9.9 6.8 6.2 7.3 8.4 5.4 8.6 6.9 7.6 7.3 5.4 9.5 6.8 8.2 6.4 37.4 40.6 37.7 44.5 40.0 40.7 39.2 37.9 42.6 35.7 40.7 57.8 36.6 25.6 19.2 17.9 32.7 52.8 50.3 47.1 27.3 56.4 40.6 32.9 37.9 21.5 25.8 36.8 41.7 34.2 40.0 42.1 21.5 44.2 1.6 48.8 40.8 44.0 48.6 23.4 22.5 54.7 32.7 35.1 20.9 59.5 6.3 37.6 37.5 25.8 24.8 43.7 20.8 35.9 20.3 28.1 54.0 5.1 28.0 35.6 30.2 12.2 48.6 31.6 26.8 13.6 52.7 75.8 25.6 29.0 23.7 89.5 34.7 27.5 42.1 34.4 32.9 25.8 39.3 21.6 26.0 35.9 57.0 42.8 30.7 50.4 30.8 66.7 UBE3A "ANCR, AS, E6-AP, EPVE6AP, FLJ26981, HPVE6A" ENSG00000114062 "Ubiquitin protein ligase E3A" Q05086 15 25333728-25439051 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Biological rhythms, Host-virus interaction, Ubl conjugation pathway" Transferase "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009723, HPA039410, HPA040380" Approved Approved Nucleoplasm,Cytosol NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 52: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Nucleoplasm Cytosol "CAB009723: AB_639982, HPA039410: AB_10671997, HPA040380: AB_2676952" "unprognostic (7.95e-2)" "unprognostic (2.61e-2)" "unprognostic (1.58e-1)" "unprognostic (2.99e-1)" "unprognostic (1.13e-1)" "unprognostic (3.55e-2)" "unprognostic (1.44e-1)" "unprognostic (3.05e-1)" "unprognostic (5.07e-2)" "unprognostic (1.69e-1)" "unprognostic (3.40e-2)" "unprognostic (4.83e-2)" "unprognostic (6.31e-2)" "unprognostic (3.08e-2)" "unprognostic (1.42e-1)" "unprognostic (1.15e-1)" "unprognostic (8.17e-2)" 29.1 29.0 28.0 27.6 30.3 32.4 32.6 42.8 41.7 33.5 14.0 33.5 22.9 32.9 29.5 32.9 29.9 24.5 40.6 31.0 28.2 32.6 42.2 24.9 33.3 22.3 23.6 37.1 27.2 38.4 15.3 28.4 24.0 31.8 28.9 32.8 23.3 28.4 109.2 26.8 29.5 30.9 19.9 26.9 26.1 45.6 28.1 41.7 41.5 92.0 34.2 32.8 20.0 29.2 55.9 33.6 77.7 46.1 45.0 56.4 38.4 84.8 54.8 59.9 55.6 76.0 27.6 103.4 61.2 68.2 57.8 51.2 106.8 62.2 75.2 54.1 32.7 85.8 49.0 43.1 65.5 107.0 60.2 60.6 56.2 58.3 71.6 60.0 47.6 87.0 89.0 71.1 95.1 32.3 84.0 29.1 50.3 62.1 46.6 88.6 117.8 45.6 51.7 91.1 80.0 59.6 72.1 72.1 102.1 51.3 57.9 56.7 59.2 102.1 84.7 52.1 64.5 77.5 103.4 139.5 60.4 56.6 55.3 14.4 12.7 17.2 17.0 11.2 19.9 17.3 18.5 20.8 16.7 22.8 20.8 18.7 2.2 29.6 22.3 15.2 15.8 9.7 28.0 30.3 42.8 41.7 31.0 28.2 22.3 23.6 24.0 19.9 28.1 29.2 56.6 96.1 80.5 112.6 74.7 71.1 83.8 40.6 84.2 82.7 59.5 42.3 175.3 42.9 58.7 38.6 56.3 52.3 74.3 43.3 19.6 51.6 139.4 53.6 75.2 58.7 68.7 64.3 187.7 49.6 49.6 64.1 52.5 63.8 62.8 84.1 44.3 58.6 46.0 80.8 196.3 55.0 12.2 60.9 41.1 61.6 56.8 64.4 53.4 87.1 53.3 54.5 54.6 126.2 124.4 59.8 41.5 64.7 95.7 102.8 51.4 50.3 59.4 59.2 78.9 119.0 80.5 146.1 88.3 78.3 90.6 74.0 63.3 65.7 52.6 98.6 UBE3B ENSG00000151148 "Ubiquitin protein ligase E3B" Q7Z3V4 12 109477402-109536705 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA041012 Approved Approved "Nuclear speckles,Mitochondria" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 6: T47d - Mammary gland" "Cluster 51: Myeloid cells - Hemostasis" "Nuclear speckles" Mitochondria "HPA041012: AB_10964435" "unprognostic (1.53e-2)" "unprognostic (1.01e-1)" "unprognostic (7.12e-2)" "unprognostic (7.37e-2)" "unprognostic (7.43e-2)" "unprognostic (1.29e-1)" "unprognostic (4.92e-2)" "unprognostic (7.19e-2)" "unprognostic (2.93e-1)" "unprognostic (4.46e-3)" "unprognostic (9.39e-2)" "unprognostic (1.23e-1)" "prognostic favorable (2.49e-5)" "unprognostic (3.35e-1)" "unprognostic (3.35e-2)" "unprognostic (2.87e-1)" "unprognostic (1.26e-1)" 13.8 16.5 14.4 10.7 16.1 9.2 13.7 13.3 15.6 14.4 16.5 17.8 12.9 14.1 13.4 18.6 16.2 12.1 26.2 14.4 12.4 16.7 16.0 13.6 12.6 13.7 14.6 15.8 14.3 22.6 13.6 13.1 14.8 15.4 18.1 14.9 14.4 14.1 34.0 19.2 15.8 14.7 12.5 15.8 16.5 12.9 16.1 12.6 18.2 29.7 13.5 17.0 14.5 20.3 17.1 26.4 20.4 14.8 33.9 27.1 17.9 22.1 25.1 26.2 17.4 28.0 17.1 10.6 16.0 36.3 22.5 21.5 20.9 28.3 25.1 23.4 14.7 20.3 17.6 25.5 21.7 16.7 16.2 31.0 25.8 25.4 30.2 39.5 28.7 24.8 22.7 9.7 30.2 26.6 11.5 24.2 21.0 19.1 31.6 18.8 19.2 20.9 22.4 30.2 19.1 34.9 25.8 34.6 17.3 23.7 35.3 17.6 26.5 32.3 9.2 16.8 16.0 21.8 19.4 18.6 32.1 13.7 27.4 22.9 12.9 12.8 12.6 14.5 12.4 13.6 12.1 9.0 12.4 10.0 10.0 13.3 16.1 13.1 12.0 11.4 16.2 10.7 14.4 16.1 13.3 15.6 14.4 12.4 13.7 14.6 14.8 12.5 16.1 20.3 11.9 12.8 15.1 34.0 9.7 5.1 11.8 13.9 6.8 19.3 14.4 12.8 35.4 11.5 17.1 16.5 33.3 17.9 12.8 21.0 11.7 17.7 15.7 12.6 12.5 14.2 9.0 13.0 24.5 15.3 11.5 11.1 18.8 12.2 9.5 20.0 11.7 18.8 12.5 21.9 23.6 15.9 18.3 19.2 6.1 32.0 12.5 14.2 10.6 13.1 17.7 13.6 32.0 21.1 38.3 25.3 13.7 9.8 15.6 17.2 19.6 19.9 18.4 25.0 6.6 9.4 13.0 10.4 13.2 13.4 7.2 23.7 10.7 17.7 16.8 18.4 UBE3C "KIAA0010, KIAA10" ENSG00000009335 "Ubiquitin protein ligase E3C" Q15386 7 157138916-157269370 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA039915 Approved Approved "Nucleoplasm,Plasma membrane,Mitochondria" NA NA "Cluster 35: T-regs - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 18: U-2197 - ECM organization" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoplasm, Mitochondria" "Plasma membrane" "HPA039915: AB_10795264" "unprognostic (2.83e-2)" "unprognostic (9.27e-3)" "unprognostic (2.41e-1)" "unprognostic (2.29e-1)" "unprognostic (1.19e-2)" "unprognostic (3.14e-2)" "unprognostic (1.36e-1)" "unprognostic (7.02e-2)" "unprognostic (2.34e-2)" "unprognostic (1.58e-1)" "unprognostic (3.01e-3)" "unprognostic (8.64e-2)" "prognostic favorable (9.18e-6)" "unprognostic (9.74e-2)" "unprognostic (1.86e-1)" "unprognostic (1.87e-1)" "unprognostic (3.60e-2)" 25.7 17.4 12.0 21.5 13.2 16.2 21.7 17.5 14.1 18.4 18.8 22.3 20.0 19.4 13.4 28.3 18.5 19.1 28.5 13.2 14.1 20.3 22.9 19.0 20.9 14.6 13.4 20.0 22.4 36.2 11.1 17.5 14.9 19.9 23.2 20.2 22.7 22.7 65.6 20.8 20.8 29.2 12.7 18.0 20.9 26.2 14.8 18.6 17.3 58.5 22.8 28.1 17.0 15.0 68.8 53.3 33.5 67.3 58.8 61.3 37.1 74.0 63.4 61.1 61.3 48.3 55.7 36.8 64.0 82.1 79.6 42.4 52.6 68.3 72.0 67.6 48.3 37.6 35.6 35.0 58.4 56.9 52.8 54.8 61.6 68.0 55.9 46.4 72.2 30.3 55.7 39.9 87.6 59.8 56.2 35.9 53.3 61.1 63.6 31.9 37.7 75.9 63.2 74.1 53.5 55.2 72.8 61.9 54.5 37.2 32.0 39.3 65.3 76.6 16.5 190.0 93.3 39.7 42.9 37.0 87.7 83.0 89.5 0.3 1.8 1.1 2.2 2.3 3.0 1.1 2.4 2.4 2.0 1.2 2.2 2.7 0.6 2.1 2.5 1.8 2.8 1.5 12.0 13.2 17.5 14.1 13.2 14.1 14.6 13.4 14.9 12.7 14.8 15.0 23.8 22.4 19.7 52.2 14.2 27.5 17.3 19.0 17.6 34.7 22.4 16.9 33.7 22.8 14.2 25.8 66.7 14.9 25.3 27.3 9.8 20.3 11.6 21.6 27.4 23.4 24.5 14.9 98.9 17.7 17.4 19.6 27.0 24.5 9.5 23.0 23.6 48.3 15.4 32.0 100.7 21.8 12.2 27.6 15.2 10.1 15.5 20.6 5.4 52.5 22.0 9.9 26.8 81.4 96.2 27.5 13.4 25.6 17.5 31.5 20.6 19.1 19.8 39.9 0.0 23.1 21.4 26.6 27.3 37.5 33.2 15.1 20.9 22.3 26.2 28.1 UBE3D "C6orf157, DKFZp434A1520, H10BH, UBE2CBP, YJR141W" ENSG00000118420 "Ubiquitin protein ligase E3D" Q7Z6J8 6 82892390-83065841 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "Excitatory neurons: 95.7;Inhibitory neurons: 74.5;Oligodendrocyte precursor cells: 78.9;Oligodendrocytes: 70.9" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027231 Approved Approved "Rods & Rings" NA NA "Cluster 35: T-regs - Unknown function" "Cluster 52: Non-specific - Ribosome" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Rods & Rings" "HPA027231: AB_2256689" "unprognostic (1.91e-1)" "unprognostic (3.60e-2)" "unprognostic (5.05e-2)" "unprognostic (6.17e-3)" "unprognostic (2.91e-3)" "unprognostic (5.03e-2)" "unprognostic (2.39e-5)" "unprognostic (6.93e-2)" "unprognostic (2.08e-1)" "unprognostic (2.70e-2)" "unprognostic (3.48e-3)" "unprognostic (1.14e-1)" "unprognostic (1.47e-1)" "unprognostic (4.26e-1)" "unprognostic (1.78e-1)" "unprognostic (1.58e-2)" "unprognostic (3.18e-1)" 1.6 2.4 0.8 1.4 1.4 0.8 1.5 0.4 2.1 1.7 0.2 1.7 2.1 1.7 1.2 1.7 5.0 1.3 1.4 1.0 1.4 2.1 1.2 1.1 1.6 0.8 1.9 2.1 2.3 1.9 2.4 1.1 1.2 1.2 1.7 3.3 1.9 1.4 2.7 1.3 1.4 1.6 1.6 1.6 1.7 1.1 1.3 2.1 2.7 2.5 1.8 2.1 1.9 1.3 2.9 4.0 3.8 3.5 3.0 4.9 3.0 3.0 3.7 3.8 6.5 5.7 1.5 13.2 4.6 1.8 6.6 3.0 7.5 3.7 6.0 5.6 17.0 7.6 2.0 6.2 4.1 6.5 3.6 3.9 5.2 4.2 5.0 2.8 5.0 7.0 11.1 5.8 3.3 3.3 4.1 8.3 4.8 10.4 6.3 6.1 8.6 5.2 7.2 3.8 6.8 4.2 1.7 4.4 2.8 5.1 2.8 4.7 1.5 1.6 4.6 3.6 7.5 6.4 13.8 4.4 2.8 12.0 3.5 0.0 0.7 0.2 3.3 2.0 4.3 4.7 3.5 2.6 2.2 3.2 3.7 5.5 0.0 1.0 0.9 1.7 4.0 2.2 0.8 1.4 0.4 2.1 1.0 1.4 0.8 1.9 1.2 1.6 1.3 1.3 4.7 6.4 6.4 35.9 8.1 6.2 5.2 6.7 6.2 11.0 2.7 2.7 3.1 2.8 5.1 7.3 35.5 7.4 10.0 1.5 1.9 5.4 2.1 15.7 6.2 5.8 7.7 2.1 95.7 4.7 4.7 5.1 2.0 2.8 1.3 6.8 4.2 2.7 5.2 6.7 74.5 5.2 8.2 4.6 3.4 1.1 6.8 3.1 7.2 36.5 2.7 3.9 3.1 78.9 70.9 3.6 5.9 4.1 4.8 3.6 3.6 5.5 31.9 14.9 6.6 11.1 4.3 7.3 14.7 4.8 6.8 3.0 5.8 8.4 6.7 3.7 UBE4A "E4, KIAA0126, UBOX2, UFD2" ENSG00000110344 "Ubiquitination factor E4A" Q14139 11 118359600-118399211 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA055035, HPA064010" Approved Supported "Nuclear speckles" NA NA "Cluster 14: Monocytes - Unknown function" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 1: K-562 - Erythropoiesis" "Cluster 59: Non-specific - Transcription" "Nuclear speckles" "HPA055035: AB_2682679, HPA064010: AB_2685174" "unprognostic (1.32e-2)" "unprognostic (8.15e-2)" "unprognostic (5.23e-3)" "unprognostic (3.34e-1)" "unprognostic (2.80e-2)" "unprognostic (1.97e-1)" "unprognostic (7.67e-3)" "unprognostic (3.31e-1)" "unprognostic (1.30e-1)" "unprognostic (4.67e-2)" "unprognostic (6.01e-2)" "unprognostic (5.83e-2)" "unprognostic (7.73e-3)" "unprognostic (4.74e-2)" "unprognostic (5.94e-2)" "unprognostic (2.72e-1)" "unprognostic (8.86e-2)" 18.6 14.1 15.9 20.3 17.8 17.7 18.0 25.5 20.5 16.1 15.7 17.4 19.1 18.9 18.6 15.0 15.5 15.6 19.7 15.1 20.2 18.0 27.6 17.0 22.5 18.9 18.1 19.1 19.5 19.0 9.5 17.5 20.2 19.0 20.7 18.4 16.1 14.9 22.1 24.0 20.5 18.1 16.5 19.7 23.9 17.7 19.7 21.3 18.4 15.9 21.6 14.7 12.7 24.4 18.8 17.9 22.4 22.5 38.0 34.9 22.3 27.1 28.1 19.7 24.0 49.7 44.9 39.3 51.0 34.4 26.5 40.3 31.9 25.7 32.6 22.3 14.8 64.5 15.4 25.7 32.6 36.8 47.3 35.4 18.2 40.4 39.3 26.3 33.3 33.9 37.2 35.9 28.7 35.4 31.5 36.5 20.9 37.7 22.7 20.0 32.5 40.2 21.6 43.1 20.3 21.1 39.2 33.5 12.3 24.2 44.8 16.6 34.6 29.0 19.0 25.1 22.8 10.5 13.8 36.4 16.1 41.6 30.4 14.2 9.5 9.7 7.5 10.5 5.8 5.1 5.6 5.4 9.8 3.5 6.0 5.4 9.6 6.5 12.8 5.7 7.0 4.8 15.9 17.8 25.5 20.5 15.1 20.2 18.9 18.1 20.2 16.5 19.7 24.4 28.7 12.8 31.9 45.7 27.5 26.8 22.0 20.4 25.6 19.5 26.3 18.0 18.2 10.0 27.8 14.7 18.8 20.3 30.6 25.5 5.9 19.8 18.0 23.7 35.3 20.9 18.6 26.9 46.2 28.5 19.8 24.2 41.8 31.7 10.8 25.7 19.2 44.6 21.9 16.8 56.3 20.1 30.5 27.9 23.1 15.2 17.1 33.2 24.9 36.5 32.4 20.5 24.7 55.8 80.9 27.0 18.3 21.4 42.0 23.1 29.0 11.5 37.5 16.8 19.7 23.4 23.6 35.3 22.0 30.3 39.2 24.8 31.0 26.0 20.3 26.1 UBE4B "E4, KIAA0684, UBOX3, UFD2" ENSG00000130939 "Ubiquitination factor E4B" O95155 1 10032832-10181239 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 99.9;Inhibitory neurons: 101.1;Oligodendrocytes: 185.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA019219 Approved NA NA "Cluster 13: T-cells - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "HPA019219: AB_1858554" "unprognostic (5.32e-2)" "unprognostic (1.56e-1)" "unprognostic (3.74e-2)" "unprognostic (5.46e-2)" "unprognostic (7.19e-2)" "unprognostic (4.39e-2)" "prognostic unfavorable (3.69e-5)" "unprognostic (2.53e-1)" "unprognostic (9.72e-2)" "unprognostic (1.12e-1)" "unprognostic (4.26e-1)" "unprognostic (3.10e-1)" "unprognostic (1.86e-3)" "unprognostic (2.99e-1)" "unprognostic (3.99e-1)" "unprognostic (1.35e-1)" "unprognostic (1.76e-3)" 13.5 22.2 13.0 12.9 18.4 20.1 13.4 19.6 16.7 15.8 9.3 24.3 16.2 19.4 12.6 22.8 14.6 12.3 23.2 13.6 13.9 13.6 13.9 11.2 12.4 19.1 15.1 23.3 26.9 21.1 15.2 20.0 20.7 14.1 13.4 19.3 15.0 12.8 41.8 25.3 15.9 17.4 10.4 12.2 20.4 9.5 16.6 17.1 21.0 27.5 14.2 17.3 16.7 28.7 37.9 24.5 28.8 31.6 37.5 49.0 22.5 24.4 31.1 24.0 24.3 26.6 43.2 32.4 29.2 43.6 18.6 27.5 37.2 28.2 28.1 33.8 20.8 35.1 41.5 30.2 27.4 36.6 23.9 40.4 24.7 32.1 26.8 43.9 35.0 23.3 61.7 42.4 22.0 19.6 24.1 16.7 38.2 24.2 19.9 23.6 28.1 34.8 23.0 17.0 35.0 26.7 38.8 26.8 49.5 30.4 21.1 26.0 30.4 21.1 32.0 26.5 20.2 18.8 27.7 37.1 30.9 41.4 28.4 3.4 4.9 2.4 3.0 3.7 5.1 3.6 5.0 5.0 4.1 3.2 4.5 3.6 5.5 1.8 2.8 1.8 6.4 3.6 13.0 18.4 19.6 16.7 13.6 13.9 19.1 15.1 20.7 10.4 16.6 28.7 13.5 22.4 24.0 65.6 17.7 17.6 14.6 13.0 21.6 14.7 18.6 13.2 42.2 15.7 12.9 9.2 25.0 33.1 12.3 12.0 9.8 12.8 3.0 22.4 23.3 15.4 16.3 33.4 99.9 14.8 13.5 18.5 14.8 24.6 6.3 27.9 17.2 16.4 16.5 16.8 101.1 16.2 16.2 22.1 10.9 4.8 11.1 16.1 5.4 46.9 22.9 10.5 19.6 82.4 185.2 19.5 19.5 8.6 24.3 19.3 25.5 10.3 12.9 33.5 19.7 15.2 16.4 8.5 15.0 35.8 22.4 20.5 18.3 21.1 18.6 18.5 UBOX5 "KIAA0860, RNF37, Ubce7ip5, UIP5" ENSG00000185019 "U-box domain containing 5" O94941 20 3107573-3160196 "Enzymes, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA028871 Approved Approved Nucleoplasm NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 52: Non-specific - Transcription" Nucleoplasm "HPA028871: AB_10603140" "unprognostic (4.11e-2)" "unprognostic (2.01e-2)" "unprognostic (1.77e-1)" "unprognostic (1.04e-1)" "unprognostic (2.18e-1)" "prognostic favorable (4.52e-5)" "unprognostic (2.58e-2)" "unprognostic (1.02e-1)" "unprognostic (3.11e-2)" "unprognostic (1.61e-1)" "prognostic favorable (1.80e-5)" "unprognostic (4.02e-2)" "unprognostic (9.71e-3)" "unprognostic (3.33e-1)" "unprognostic (5.58e-2)" "unprognostic (1.07e-2)" "unprognostic (1.61e-2)" 4.5 4.4 4.3 2.7 5.1 6.9 4.5 5.5 5.1 4.8 2.4 6.2 2.8 5.9 2.7 4.4 4.8 2.6 3.8 4.5 3.8 4.4 3.5 3.7 3.7 3.8 3.7 5.0 6.1 5.4 4.4 3.4 3.5 5.2 2.9 3.8 4.8 4.4 11.2 7.6 4.2 4.1 3.2 4.3 4.7 4.8 3.9 3.8 3.8 6.8 3.0 5.6 4.2 6.1 6.1 6.1 4.8 3.1 6.3 3.5 2.6 4.9 4.7 6.1 6.0 5.8 5.2 4.8 2.0 4.2 7.0 8.5 3.2 7.8 3.6 1.4 2.7 7.9 2.1 5.4 5.0 3.9 2.9 4.5 5.6 4.9 6.2 5.0 3.9 3.7 6.7 4.4 3.5 4.5 7.0 5.0 3.7 6.3 3.7 4.7 5.8 3.3 3.8 6.7 5.9 5.7 3.4 18.8 4.0 3.7 8.1 2.5 4.3 4.0 2.7 4.6 4.4 5.9 9.4 4.2 2.1 3.5 3.0 7.9 5.1 9.4 4.4 5.1 5.0 6.3 5.2 3.6 5.5 4.8 5.3 5.1 8.1 5.2 5.3 3.7 5.6 4.6 4.3 5.1 5.5 5.1 4.5 3.8 3.8 3.7 3.5 3.2 3.9 6.1 2.4 12.8 6.0 6.8 3.6 1.9 4.1 3.4 0.6 6.6 2.8 2.0 1.1 1.5 3.1 0.0 6.2 6.9 1.9 5.6 0.0 4.0 1.4 2.5 2.5 3.6 10.2 0.4 9.6 4.2 4.4 3.5 5.1 2.7 2.5 4.5 4.6 4.3 4.9 6.7 8.5 4.9 6.1 5.0 3.2 1.9 6.8 3.5 3.6 3.7 6.6 4.5 4.1 4.5 10.4 3.9 3.4 3.8 2.3 5.8 4.7 5.2 2.7 5.2 6.6 5.2 2.8 10.2 5.2 1.6 2.4 10.1 3.1 3.8 5.3 5.9 UBR1 ENSG00000159459 "Ubiquitin protein ligase E3 component n-recognin 1" Q8IWV7 15 42942897-43106113 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 48.6" "Cell type enhanced" "Detected in many" "Excitatory neurons: 108.9;Inhibitory neurons: 108.8;Oligodendrocyte precursor cells: 102.1;Oligodendrocytes: 127.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA038838, HPA038839" Approved Approved Nucleoplasm,Vesicles,Cytosol NA NA "Cluster 41: Basophils - Cellular respiration" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 59: Non-specific - Transcription" Vesicles "Nucleoplasm, Cytosol" "HPA038838: AB_10673120, HPA038839: " "unprognostic (1.07e-2)" "unprognostic (5.02e-2)" "unprognostic (9.77e-2)" "unprognostic (1.55e-2)" "unprognostic (1.89e-2)" "unprognostic (1.29e-1)" "unprognostic (2.67e-1)" "unprognostic (1.49e-1)" "unprognostic (4.79e-1)" "unprognostic (2.97e-2)" "unprognostic (1.93e-2)" "unprognostic (1.79e-1)" "unprognostic (1.27e-3)" "unprognostic (5.78e-2)" "unprognostic (1.52e-1)" "unprognostic (2.00e-1)" "unprognostic (1.89e-1)" 9.1 7.9 12.5 8.8 29.4 24.9 9.3 11.7 17.4 9.9 4.8 8.6 7.8 10.7 7.4 5.8 8.0 8.6 13.7 11.6 31.5 9.2 7.1 8.6 10.9 24.2 18.3 7.7 9.5 14.3 6.6 10.5 21.6 10.0 8.0 14.3 6.3 10.5 12.0 5.6 7.8 9.6 8.5 9.5 7.2 10.1 21.2 13.3 12.6 14.0 8.7 9.1 5.8 48.6 7.4 10.2 11.6 9.6 17.1 14.7 10.7 17.6 19.4 15.9 19.2 13.3 5.5 8.6 10.1 18.4 18.9 12.4 17.1 15.5 18.1 18.0 8.4 33.1 20.4 6.3 12.3 23.0 14.4 15.3 8.4 18.8 14.8 14.6 17.0 16.7 19.6 12.3 18.7 4.5 12.7 6.8 6.5 18.9 10.6 16.4 15.7 6.4 14.9 16.6 12.0 10.3 22.7 12.0 7.7 13.1 10.9 12.2 24.3 17.9 11.1 16.7 18.0 14.6 26.4 23.6 12.2 14.6 16.6 3.7 1.5 2.5 2.4 1.8 2.9 1.9 2.6 2.9 1.4 2.3 2.6 3.2 2.9 3.2 1.7 2.2 1.9 0.9 12.5 29.4 11.7 17.4 11.6 31.5 24.2 18.3 21.6 8.5 21.2 48.6 46.4 48.1 30.7 73.1 28.9 10.6 11.6 9.3 17.1 27.5 15.4 10.8 28.0 12.8 19.1 9.2 27.1 14.7 35.8 12.8 0.0 10.8 16.8 13.4 27.4 24.5 14.4 23.8 108.9 14.4 7.7 25.6 20.9 18.2 28.5 22.8 17.2 9.9 8.1 32.0 108.8 10.9 14.2 16.4 10.6 16.9 16.1 17.1 8.8 73.1 15.6 13.5 23.7 102.1 127.6 10.3 8.2 20.7 33.2 7.7 12.3 9.2 15.7 38.8 13.1 34.7 36.5 27.0 17.8 8.6 7.2 36.9 31.4 16.5 10.6 9.8 UBR2 "bA49A4.1, C6orf133, dJ392M17.3, KIAA0349" ENSG00000024048 "Ubiquitin protein ligase E3 component n-recognin 2" Q8IWV8 6 42564029-42693505 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 138.5;Inhibitory neurons: 142.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "neutrophil: 38.5" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA027869, HPA027880" Approved Approved "Nucleoplasm,Plasma membrane" NA NA "Cluster 1: Neutrophils - Mixed function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 21: OE19 - Mitochondria" "Cluster 6: Erythroid cells - Oxygen transport" Nucleoplasm "Plasma membrane" "HPA027869: AB_10600416, HPA027880: AB_10601217" "unprognostic (3.26e-1)" "unprognostic (1.29e-1)" "unprognostic (8.33e-2)" "unprognostic (2.95e-2)" "unprognostic (1.08e-2)" "unprognostic (4.23e-2)" "unprognostic (1.32e-1)" "unprognostic (7.24e-2)" "unprognostic (5.05e-2)" "prognostic favorable (1.65e-4)" "unprognostic (1.12e-1)" "unprognostic (7.53e-2)" "unprognostic (1.30e-2)" "unprognostic (3.88e-1)" "unprognostic (1.81e-1)" "unprognostic (5.78e-2)" "unprognostic (7.77e-3)" 11.0 10.7 8.5 12.7 10.1 17.9 12.9 14.1 11.1 10.3 11.3 12.7 14.4 10.9 11.2 9.5 9.4 8.6 11.2 9.0 8.8 12.1 17.2 11.9 12.7 9.0 8.7 12.2 15.6 15.0 8.8 11.7 9.3 10.5 13.8 29.7 12.0 10.0 22.8 12.2 13.8 10.6 8.6 15.3 12.2 6.2 9.1 13.5 13.3 22.3 11.5 10.8 10.4 14.2 18.5 9.0 10.4 16.4 20.9 20.0 14.0 13.8 14.9 12.0 12.4 13.2 7.4 12.5 10.7 15.0 13.9 18.1 15.1 11.8 15.2 17.1 10.6 20.0 13.3 17.3 17.0 19.6 13.1 14.1 12.7 12.0 12.9 14.8 13.7 17.9 23.7 15.4 11.7 14.9 15.4 17.1 9.5 36.2 8.7 13.6 15.5 19.0 13.8 15.7 12.4 9.8 14.0 13.3 13.9 15.7 13.0 18.7 19.8 10.8 8.4 13.5 10.1 14.1 13.4 18.9 5.7 14.5 6.8 17.7 7.1 15.2 6.5 7.3 5.4 5.2 4.2 5.1 5.5 5.2 4.3 4.8 38.5 5.9 9.8 4.1 5.3 3.4 8.5 10.1 14.1 11.1 9.0 8.8 9.0 8.7 9.3 8.6 9.1 14.2 33.5 16.0 24.6 82.6 33.9 16.6 18.1 14.9 28.5 43.0 20.4 15.9 39.3 30.0 22.1 20.2 60.5 17.4 46.6 51.6 17.6 18.5 12.4 27.5 30.8 24.8 12.6 75.1 138.5 15.3 13.4 26.5 34.1 32.9 20.3 31.3 21.8 35.0 13.2 63.9 142.7 22.5 14.2 26.7 28.6 3.9 25.4 26.1 19.6 87.1 43.0 23.5 32.0 123.1 131.4 15.0 29.1 24.0 50.6 22.8 37.2 11.7 27.9 53.5 39.5 30.0 27.2 11.2 10.9 28.1 16.2 17.2 44.0 24.0 21.5 22.7 UBR3 "DKFZp434P117, FLJ37422, KIAA2024, ZNF650" ENSG00000144357 "Ubiquitin protein ligase E3 component n-recognin 3" Q6ZT12 2 169827454-170084131 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 71.2;tongue: 87.1" "Cell type enhanced" "Detected in all" "Astrocytes: 162.6;Excitatory neurons: 305.1;Inhibitory neurons: 302.0;Oligodendrocyte precursor cells: 232.2;Oligodendrocytes: 288.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in single" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA035390 Approved Approved Nucleoplasm,Nucleoli NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 13: Striated muscle - Muscle contraction" "Cluster 36: HEL - Hemostasis" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Nucleoplasm, Nucleoli" "HPA035390: AB_10670699" "unprognostic (1.35e-2)" "unprognostic (1.24e-1)" "unprognostic (1.59e-2)" "unprognostic (1.27e-1)" "unprognostic (2.07e-2)" "unprognostic (1.24e-1)" "unprognostic (1.00e-1)" "unprognostic (3.91e-2)" "unprognostic (1.05e-1)" "unprognostic (1.24e-1)" "unprognostic (1.76e-1)" "unprognostic (1.26e-1)" "unprognostic (3.19e-2)" "unprognostic (5.56e-2)" "unprognostic (2.01e-1)" "unprognostic (3.38e-1)" "unprognostic (2.18e-1)" 14.2 12.4 4.4 7.7 5.8 7.4 9.2 5.9 8.5 10.9 2.8 8.8 8.1 10.1 6.9 12.8 8.4 9.3 29.4 8.0 3.3 15.2 21.0 8.8 7.2 2.4 2.7 10.2 11.9 21.5 2.1 8.7 3.3 13.1 8.5 21.2 11.5 10.3 71.2 9.2 7.5 11.1 3.2 8.8 9.3 9.7 3.4 9.5 17.9 87.1 7.3 11.0 2.3 8.4 14.8 12.4 12.9 17.1 25.0 19.7 10.8 26.1 15.0 14.7 11.8 19.1 9.1 16.7 22.2 20.5 12.0 19.0 15.5 13.2 18.2 17.4 13.4 61.1 12.6 20.3 12.4 20.4 18.9 11.9 12.1 19.3 12.9 11.7 14.8 8.3 32.4 17.6 25.6 14.0 13.3 10.0 10.1 14.9 10.2 12.6 21.1 17.8 10.5 20.5 25.1 13.7 18.4 16.7 10.6 10.2 10.9 11.4 18.9 22.1 9.0 17.5 16.7 14.2 11.9 15.1 18.2 11.8 12.5 0.0 0.6 0.5 0.9 0.6 1.3 0.6 0.5 0.8 0.9 0.3 0.9 1.2 0.6 0.8 0.5 0.7 1.0 0.4 4.4 5.8 5.9 8.5 8.0 3.3 2.4 2.7 3.3 3.2 3.4 8.4 19.0 44.8 26.9 162.6 16.3 25.9 12.4 14.8 20.5 46.3 15.8 8.9 109.7 17.2 20.0 12.9 81.3 19.7 22.9 17.1 3.9 8.7 7.6 16.8 21.9 26.4 16.7 24.4 305.1 11.0 8.4 22.2 23.4 22.0 16.5 22.7 30.4 39.0 10.2 63.9 302.0 11.3 22.4 20.9 18.7 10.2 25.7 18.7 16.0 110.5 18.7 61.7 14.4 232.2 288.0 10.7 15.0 19.2 21.3 20.9 15.3 10.0 13.4 51.5 26.3 29.0 21.8 12.4 8.6 22.9 29.0 23.0 18.1 17.3 13.2 17.2 UBR4 "KIAA0462, KIAA1307, RBAF600, ZUBR1" ENSG00000127481 "Ubiquitin protein ligase E3 component n-recognin 4" Q5T4S7 1 19074510-19210266 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Host-virus interaction, Ubl conjugation pathway" "Calmodulin-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Basal keratinocytes: 271.0;Suprabasal keratinocytes: 252.9;Urothelial cells: 236.5" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 39.8" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA013394, HPA021046" Approved Supported Nucleoplasm,Centrosome,Cytosol NA NA 15000 "Cluster 25: Monocytes - Inflammatory response" "Cluster 31: Skin - Epidermis development" "Cluster 21: OE19 - Mitochondria" "Cluster 22: Epithelial cell types - Mixed function" Nucleoplasm "Centrosome, Cytosol" "HPA013394: , HPA021046: AB_1858578" "unprognostic (1.37e-1)" "unprognostic (2.57e-2)" "unprognostic (2.82e-2)" "unprognostic (2.02e-1)" "unprognostic (8.78e-2)" "unprognostic (9.77e-2)" "unprognostic (1.14e-3)" "unprognostic (3.09e-1)" "unprognostic (1.96e-1)" "unprognostic (9.14e-3)" "unprognostic (7.48e-2)" "unprognostic (2.53e-1)" "unprognostic (7.68e-3)" "unprognostic (4.30e-1)" "unprognostic (1.19e-1)" "unprognostic (5.58e-2)" "unprognostic (1.52e-1)" 56.2 62.8 48.2 23.0 46.0 79.8 49.8 38.7 48.4 57.4 47.6 69.6 20.9 61.7 35.7 55.4 52.3 29.6 58.7 45.8 46.0 74.7 82.7 71.9 25.7 51.5 46.4 75.3 53.5 35.5 70.7 27.5 54.9 67.2 22.7 44.6 48.0 27.0 129.1 161.9 59.7 26.0 35.2 62.8 70.6 105.3 45.9 34.6 56.5 45.0 25.7 90.0 59.2 44.7 61.4 60.7 53.5 39.7 97.6 50.0 46.2 46.5 48.8 49.5 44.7 97.2 51.3 36.6 42.3 61.7 43.3 40.8 42.3 46.3 46.0 30.6 37.5 83.8 63.3 64.1 68.6 51.9 53.4 45.0 57.9 100.8 96.3 48.1 54.9 63.7 58.5 32.9 47.6 43.6 24.7 62.9 43.5 124.3 33.6 34.0 41.7 31.0 44.7 35.2 37.7 37.4 55.0 31.1 39.9 48.6 21.7 40.4 85.9 57.4 36.1 69.0 52.8 38.8 25.2 41.5 39.3 79.3 50.3 39.8 28.7 4.7 4.9 5.9 4.2 7.4 4.4 2.9 14.2 4.0 3.9 3.7 15.4 4.4 2.1 6.5 3.4 8.3 48.2 46.0 38.7 48.4 45.8 46.0 51.5 46.4 54.9 35.2 45.9 44.7 28.1 35.3 37.6 85.5 30.3 271.0 124.6 28.9 28.5 57.5 22.1 23.9 19.1 37.1 30.4 31.3 152.2 24.7 34.2 31.6 13.7 41.3 21.4 39.8 32.0 30.8 17.5 48.4 58.9 40.9 17.0 32.2 44.9 50.4 19.6 32.9 31.1 94.1 63.2 79.1 61.8 29.2 12.2 43.0 48.7 28.7 30.7 46.4 49.8 34.7 64.4 28.8 21.6 51.8 44.5 61.0 16.7 35.7 26.4 59.1 57.9 135.6 39.1 48.5 19.7 28.3 30.1 44.8 21.0 28.0 252.9 33.9 32.7 34.5 20.1 236.5 UBR5 "DD5, EDD, EDD1, HYD, KIAA0896" ENSG00000104517 "Ubiquitin protein ligase E3 component n-recognin 5" O95071 8 102252273-102412759 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins" "DNA damage, DNA repair, Host-virus interaction, Ubl conjugation pathway" Transferase "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Astrocytes: 239.9;Excitatory neurons: 214.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA053688 Supported Nucleoplasm,Cytosol NA NA "Cluster 35: T-regs - Unknown function" "Cluster 34: Non-specific - Transcription" "Cluster 27: U-698-M & Daudi - Adaptive immune response" "Cluster 44: Endometrium - Transcription" Nucleoplasm Cytosol "HPA053688: AB_2682230" "unprognostic (3.79e-3)" "unprognostic (7.44e-3)" "unprognostic (1.25e-1)" "unprognostic (2.10e-2)" "unprognostic (2.44e-2)" "unprognostic (1.41e-1)" "prognostic unfavorable (1.26e-4)" "unprognostic (2.50e-1)" "unprognostic (1.75e-2)" "unprognostic (7.54e-3)" "unprognostic (8.29e-3)" "unprognostic (3.84e-2)" "unprognostic (6.64e-2)" "unprognostic (3.16e-1)" "unprognostic (1.94e-1)" "unprognostic (1.69e-2)" "unprognostic (2.45e-1)" 33.0 18.3 16.6 22.4 19.4 36.5 30.9 26.5 24.0 25.6 23.4 33.3 14.9 29.6 23.7 27.5 26.1 17.3 25.8 17.3 16.0 17.5 17.7 29.8 33.6 16.0 16.1 32.2 25.7 30.4 24.4 17.8 15.7 20.0 17.0 45.4 26.1 20.7 50.1 35.6 27.2 17.2 13.7 24.2 25.0 43.9 16.6 43.0 21.0 29.6 28.6 28.2 26.4 18.9 64.5 28.4 53.2 27.5 51.8 52.2 48.9 47.4 41.9 36.6 31.7 28.3 42.1 127.1 39.8 44.5 23.7 38.2 46.2 41.1 51.1 55.3 22.7 106.5 39.7 52.2 46.1 33.7 56.3 60.1 40.4 37.5 64.5 41.5 44.6 35.6 52.3 70.2 34.8 58.0 85.3 40.3 40.1 61.8 31.6 49.3 31.6 60.9 33.5 62.3 39.1 32.5 33.4 31.8 34.3 46.1 51.4 35.1 44.6 38.5 44.9 35.1 33.5 37.3 38.7 129.5 38.0 51.2 32.0 1.8 1.5 2.4 2.4 1.5 2.4 2.1 2.5 2.5 1.8 1.7 2.0 3.0 3.0 1.1 2.7 1.6 3.4 1.0 16.6 19.4 26.5 24.0 17.3 16.0 16.0 16.1 15.7 13.7 16.6 18.9 51.4 25.6 31.7 239.9 44.8 52.3 41.2 26.3 55.8 52.0 37.3 29.6 39.8 8.6 49.9 31.3 68.8 27.7 36.2 20.9 9.8 18.8 38.6 47.5 47.0 40.1 33.4 33.2 214.2 15.0 18.9 43.7 37.8 69.0 29.8 64.3 22.9 19.0 17.0 57.2 191.7 19.5 26.4 31.4 52.6 23.6 39.7 43.7 44.4 129.3 43.5 31.3 26.8 196.6 174.0 21.4 18.3 36.5 65.9 45.2 18.3 9.0 46.5 44.8 13.1 66.3 48.4 59.4 30.2 46.8 61.1 69.6 46.9 30.8 19.5 53.5 UBR7 C14orf130 ENSG00000012963 "Ubiquitin protein ligase E3 component n-recognin 7" Q8N806 14 93207241-93229215 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 8 "Early spermatids: 300.9;Late spermatids: 372.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA000861 Approved Approved Nucleoplasm NA NA "Cluster 31: Non-specific - Inflammatory response" "Cluster 63: T-cells - Adaptive immune response" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 34: Spermatids - Unknown function" Nucleoplasm "HPA000861: AB_1078321" "unprognostic (9.60e-2)" "unprognostic (5.12e-3)" "unprognostic (1.11e-1)" "unprognostic (9.20e-2)" "unprognostic (3.30e-1)" "unprognostic (2.12e-1)" "prognostic unfavorable (8.12e-5)" "unprognostic (1.14e-1)" "unprognostic (9.83e-2)" "unprognostic (1.04e-2)" "unprognostic (4.30e-2)" "unprognostic (5.94e-2)" "prognostic favorable (9.76e-5)" "unprognostic (3.61e-2)" "unprognostic (2.91e-1)" "unprognostic (2.86e-1)" "unprognostic (1.78e-1)" 12.7 10.4 16.9 13.2 19.1 21.1 19.1 16.3 20.2 17.6 17.7 16.9 11.8 14.4 14.0 13.0 14.4 13.1 22.0 18.8 15.9 16.6 15.1 12.7 22.2 15.3 16.1 17.6 22.9 25.7 8.9 10.3 16.0 14.6 18.3 24.3 12.7 15.3 17.5 15.7 13.2 15.3 17.1 14.1 14.2 19.0 17.3 34.0 16.8 25.9 27.3 13.6 10.9 18.8 26.1 33.0 52.2 44.2 24.2 24.0 18.6 54.0 38.6 57.1 43.9 23.5 28.2 60.9 42.6 28.3 26.0 30.7 55.8 30.1 60.7 46.4 29.2 45.7 33.1 23.7 11.2 65.7 47.5 15.5 20.7 33.8 21.2 21.7 33.1 54.8 41.5 60.5 57.7 77.3 104.5 35.7 24.1 69.4 61.9 81.9 92.9 33.6 20.6 42.0 65.3 45.4 39.5 32.1 16.3 31.1 58.4 44.6 24.0 43.1 23.0 37.0 56.3 69.0 103.4 61.1 37.0 49.8 38.7 34.5 11.3 18.2 17.8 14.2 19.5 26.4 16.4 16.4 11.4 20.4 13.6 15.1 16.6 18.1 18.3 15.0 26.7 13.4 16.9 19.1 16.3 20.2 18.8 15.9 15.3 16.1 16.0 17.1 17.3 18.8 13.8 16.0 6.4 9.4 16.1 19.9 8.3 8.0 6.8 6.1 11.6 11.0 19.7 11.5 8.5 11.0 10.4 12.3 15.1 15.6 11.7 9.9 300.9 8.2 8.5 11.0 5.4 20.2 16.3 12.9 15.2 12.0 9.7 9.1 5.1 8.8 12.8 11.3 14.0 3.3 12.7 8.4 12.2 10.7 10.9 372.2 9.3 9.0 14.2 7.5 9.3 13.5 13.4 10.6 13.9 8.9 5.4 12.4 26.0 4.7 10.3 9.3 5.5 13.9 6.6 11.2 10.1 38.7 23.2 10.7 13.5 6.6 12.4 6.2 12.4 6.0 UCK1 "FLJ12255, URK1" ENSG00000130717 "Uridine-cytidine kinase 1" Q9HA47 9 131523801-131531264 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA050969, HPA070526" Approved Approved Nucleoplasm,Nucleoli NA NA "Cluster 35: T-regs - Unknown function" "Cluster 39: Non-specific - Mitochondria" "Cluster 40: Non-specific - Basic cellular processes" "Cluster 39: Non-specific - Basic cellular processes" Nucleoplasm Nucleoli "HPA050969: AB_2681294, HPA070526: " "unprognostic (2.20e-1)" "prognostic favorable (3.19e-4)" "unprognostic (1.16e-2)" "unprognostic (1.74e-3)" "unprognostic (7.29e-2)" "unprognostic (1.43e-1)" "unprognostic (8.71e-2)" "unprognostic (1.78e-1)" "unprognostic (2.44e-1)" "unprognostic (1.18e-1)" "unprognostic (1.36e-3)" "unprognostic (1.54e-1)" "prognostic favorable (2.21e-7)" "unprognostic (5.11e-2)" "unprognostic (3.29e-2)" "unprognostic (1.74e-1)" "unprognostic (1.07e-1)" 21.5 25.3 40.3 10.2 41.2 16.4 20.4 40.5 45.2 21.2 37.0 26.0 11.8 20.2 18.7 21.2 19.9 12.2 28.1 38.1 39.2 29.3 52.7 17.2 15.1 41.6 41.4 22.2 29.8 22.6 24.2 14.3 40.0 26.9 9.3 13.5 25.6 17.3 43.9 19.1 18.0 11.2 40.7 20.9 24.9 20.4 42.1 17.5 23.4 26.8 11.5 20.9 17.2 40.9 13.9 30.0 33.9 43.8 23.6 16.7 28.9 22.0 32.1 37.0 28.0 30.1 12.4 15.0 12.9 26.4 28.9 26.3 31.9 28.0 15.8 27.7 29.8 14.0 46.3 19.2 33.6 23.2 19.9 18.8 25.8 29.9 21.6 22.4 23.0 36.3 17.9 11.2 27.6 55.2 31.9 11.8 40.4 27.0 29.6 30.1 52.5 25.1 24.1 13.0 45.7 28.9 31.8 23.9 34.3 15.4 46.6 13.5 17.1 40.9 20.7 25.7 21.7 22.7 31.3 19.4 20.3 16.0 29.1 2.1 5.5 9.0 7.3 7.2 9.8 7.4 8.5 6.4 5.2 8.0 11.3 5.6 3.6 7.0 2.6 5.9 12.0 5.6 40.3 41.2 40.5 45.2 38.1 39.2 41.6 41.4 40.0 40.7 42.1 40.9 13.6 16.0 5.0 7.8 12.4 14.3 10.3 9.9 12.5 18.0 16.2 20.1 14.0 4.3 6.2 14.7 8.4 33.8 12.0 20.4 29.4 22.7 21.9 9.0 10.2 14.3 12.1 3.0 4.7 26.2 17.5 15.7 6.6 9.2 2.5 16.2 13.2 20.5 26.4 26.9 6.1 11.6 16.2 10.0 13.4 33.3 17.7 14.0 16.0 4.7 20.4 22.0 9.2 2.0 6.0 18.6 12.3 19.9 8.0 14.3 21.1 31.6 3.1 13.1 19.7 12.4 17.2 32.8 33.4 11.8 12.5 25.7 10.0 14.9 14.8 8.5 UCK2 UMPK ENSG00000143179 "Uridine-cytidine kinase 2" Q9BZX2 1 165827614-165911618 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 110.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA057128 Approved Nucleoplasm NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 52: Non-specific - Ribosome" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 23: Spermatids - Flagellum & Golgi organization" Nucleoplasm "HPA057128: AB_2683346" "unprognostic (5.37e-2)" "unprognostic (1.75e-2)" "unprognostic (2.51e-1)" "unprognostic (1.20e-2)" "unprognostic (4.54e-2)" "unprognostic (6.83e-3)" "prognostic unfavorable (9.22e-8)" "prognostic unfavorable (4.98e-4)" "prognostic unfavorable (6.70e-4)" "unprognostic (3.04e-2)" "unprognostic (1.49e-1)" "unprognostic (1.13e-2)" "prognostic unfavorable (5.12e-13)" "unprognostic (2.49e-3)" "unprognostic (1.14e-1)" "unprognostic (2.01e-3)" "unprognostic (1.83e-1)" 12.8 6.0 5.9 9.2 6.0 11.8 15.3 8.9 7.7 8.3 2.5 14.5 13.9 8.0 15.2 17.4 7.5 5.0 9.2 7.2 7.1 7.0 10.6 9.9 8.5 8.0 8.9 5.5 16.0 4.8 7.4 28.0 9.9 6.8 14.1 3.7 13.1 8.4 17.0 13.9 13.2 8.5 5.7 5.9 11.2 6.0 6.2 17.7 5.2 10.8 10.6 14.2 9.9 6.0 66.1 67.7 36.6 34.4 20.2 32.9 49.3 63.4 59.7 86.7 92.2 70.6 75.3 32.3 43.5 57.6 35.2 46.3 88.6 106.2 72.3 51.3 40.8 40.2 52.3 81.8 56.2 72.1 29.2 35.0 52.1 176.6 111.7 21.5 60.8 73.6 95.3 43.0 78.1 54.1 63.6 49.4 103.4 104.7 54.5 27.8 37.6 112.5 43.5 37.6 51.5 58.3 47.2 104.4 48.8 83.3 62.5 65.9 32.9 41.4 52.1 50.3 71.9 49.8 84.9 116.0 36.7 50.1 33.3 0.8 5.9 0.1 1.5 3.7 3.6 3.3 1.6 2.5 15.1 4.4 0.1 1.4 0.1 3.8 4.2 13.9 2.2 1.9 5.9 6.0 8.9 7.7 7.2 7.1 8.0 8.9 9.9 5.7 6.2 6.0 10.2 0.0 1.1 10.7 6.6 22.9 29.6 18.3 19.9 4.2 22.4 26.2 5.7 8.6 8.8 9.2 0.0 4.4 12.9 41.5 7.9 14.7 110.4 8.7 12.1 22.3 6.7 10.7 32.8 22.2 60.1 12.4 17.3 11.4 0.0 15.4 5.0 5.8 13.0 0.0 33.1 16.1 14.2 4.1 10.2 56.2 6.5 7.9 10.6 30.0 13.5 4.5 9.2 19.6 23.3 54.8 16.1 3.4 25.8 33.0 31.4 6.7 4.5 4.6 0.0 23.0 15.3 5.6 12.0 26.9 29.7 26.4 4.1 5.4 20.4 22.3 UCKL1 "FLJ20517, URKL1" ENSG00000198276 "Uridine-cytidine kinase 1 like 1" Q9NWZ5 20 63939829-63956416 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Host-virus interaction" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Rod photoreceptor cells: 148.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA004722, HPA004769" Approved Approved "Endoplasmic reticulum" NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 72: Non-specific - Transcription" "Cluster 39: CACO-2 - Unknown function" "Cluster 46: Photoreceptor cells - Phototransduction" "Endoplasmic reticulum" "HPA004722: AB_1080455, HPA004769: AB_1080453" "unprognostic (1.03e-1)" "unprognostic (2.77e-2)" "unprognostic (2.64e-1)" "unprognostic (8.34e-2)" "unprognostic (7.29e-2)" "unprognostic (1.20e-1)" "unprognostic (1.99e-2)" "unprognostic (1.87e-1)" "unprognostic (2.45e-1)" "unprognostic (1.29e-1)" "prognostic favorable (4.42e-4)" "unprognostic (5.87e-2)" "unprognostic (3.18e-2)" "unprognostic (9.11e-2)" "unprognostic (2.81e-1)" "unprognostic (3.01e-1)" "unprognostic (5.26e-3)" 41.9 47.3 21.2 17.4 23.2 24.7 44.0 32.0 33.2 53.7 24.4 46.9 33.5 41.9 7.2 50.4 49.8 11.9 57.1 20.4 21.2 55.1 55.6 40.6 21.2 23.9 21.5 74.9 46.3 17.2 52.3 17.9 23.7 49.4 8.7 55.9 43.4 17.6 61.1 43.0 51.8 9.6 19.4 64.7 37.2 25.7 22.7 15.9 59.0 36.6 11.0 40.1 54.0 31.4 29.2 30.3 25.5 34.2 18.4 15.6 40.9 22.8 15.4 46.2 23.0 72.8 22.0 29.3 37.5 14.9 31.6 46.7 20.0 31.4 9.2 12.3 33.6 22.2 67.8 108.1 20.3 38.2 40.8 21.9 27.6 18.5 15.1 18.3 21.5 28.4 32.1 30.3 14.6 37.4 45.1 66.3 18.9 23.0 70.0 45.4 19.2 51.0 19.1 41.4 60.3 35.3 32.9 31.8 36.2 12.7 33.4 34.1 24.2 48.7 18.2 32.1 30.1 31.5 18.1 13.6 25.0 27.1 18.8 8.0 11.4 9.9 18.3 19.7 21.0 31.0 17.8 15.8 13.3 17.1 10.1 12.4 1.8 8.5 22.2 7.6 20.8 12.1 21.2 23.2 32.0 33.2 20.4 21.2 23.9 21.5 23.7 19.4 22.7 31.4 31.7 25.6 8.3 17.0 24.1 18.9 21.4 29.9 14.8 30.7 13.5 17.3 20.3 18.6 17.7 9.2 83.4 31.2 16.8 24.7 23.5 19.4 2.4 18.2 17.0 19.4 21.5 5.5 7.8 11.1 23.6 17.5 25.0 22.7 13.3 21.1 13.6 12.4 17.6 20.2 9.7 21.2 32.6 11.4 16.4 3.7 17.7 14.5 10.6 4.7 17.0 18.5 12.3 10.1 12.2 17.5 27.4 20.7 21.4 17.8 38.7 16.1 11.3 148.0 26.3 16.2 30.1 12.7 12.4 22.5 19.0 33.4 22.0 28.4 24.3 19.2 UGCG GCS ENSG00000148154 "UDP-glucose ceramide glucosyltransferase" Q16739 9 111896814-111935369 "Enzymes, FDA approved drug targets, Metabolic proteins, Predicted membrane proteins, Transporters" "Lipid biosynthesis, Lipid metabolism, Sphingolipid metabolism" "Glycosyltransferase, Transferase" "FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 112.9" "Cell type enhanced" "Detected in all" "Glandular and luminal cells: 294.5;Urothelial cells: 534.7" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 21 "plasmacytoid DC: 109.7" "Lineage enriched" "Detected in all" 21 "dendritic cells: 109.7" "Cell line enhanced" "Detected in all" "LHCN-M2: 195.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA024124 Approved NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 40: Neutrophils - Inflammatory response" "Cluster 4: Mesenchymal cell lines - Antiviral immune response" "Cluster 22: Epithelial cell types - Mixed function" "HPA024124: AB_1858595" "unprognostic (1.22e-2)" "prognostic favorable (6.62e-4)" "unprognostic (5.39e-2)" "prognostic favorable (4.44e-5)" "unprognostic (1.53e-2)" "unprognostic (9.70e-2)" "unprognostic (3.20e-2)" "unprognostic (2.04e-1)" "unprognostic (3.40e-1)" "unprognostic (1.31e-1)" "unprognostic (1.95e-2)" "unprognostic (3.22e-1)" "unprognostic (9.84e-3)" "unprognostic (2.24e-2)" "unprognostic (4.92e-2)" "unprognostic (1.99e-1)" "unprognostic (3.77e-2)" 39.1 65.6 9.5 34.6 9.6 112.9 25.2 11.1 10.9 23.1 10.4 20.5 23.8 16.3 7.3 40.8 15.7 42.6 14.4 9.7 13.1 29.7 32.5 33.7 41.8 11.0 12.4 12.0 16.6 5.5 12.5 27.6 10.3 13.8 17.8 12.2 14.1 7.7 9.0 32.8 31.7 21.4 10.2 35.5 47.9 7.9 11.6 20.5 9.9 7.7 46.8 72.3 28.5 13.7 93.4 9.8 15.7 10.5 33.2 39.7 8.3 57.0 59.7 65.3 87.9 19.8 70.0 21.9 44.1 38.0 142.9 46.6 18.4 24.7 69.6 8.9 10.7 8.9 14.3 9.8 23.7 9.8 13.8 39.6 18.9 62.4 89.1 151.0 20.3 10.8 49.4 41.5 195.7 15.9 10.7 10.9 17.9 31.4 10.1 12.4 111.5 7.1 151.0 35.2 7.6 12.0 25.3 21.1 66.1 92.2 113.6 10.1 96.6 30.0 15.2 84.8 41.1 7.7 30.3 10.2 37.0 6.1 41.6 0.1 0.3 0.2 1.2 0.7 2.0 4.2 2.2 1.6 1.9 5.3 2.0 2.0 1.2 1.4 1.0 109.7 3.6 1.4 9.5 9.6 11.1 10.9 9.7 13.1 11.0 12.4 10.3 10.2 11.6 13.7 128.0 41.7 51.1 17.6 66.6 75.7 151.6 90.6 76.8 29.8 71.8 37.8 11.8 47.1 130.7 29.5 62.6 7.3 262.4 69.8 17.6 108.2 20.6 125.0 83.4 116.1 18.5 26.5 40.4 50.6 12.8 64.6 121.8 294.5 10.8 18.3 90.7 20.6 21.4 18.5 41.9 55.1 36.7 34.0 109.2 5.9 49.0 49.1 58.7 24.4 44.4 8.4 9.2 25.1 12.8 72.2 65.1 38.4 33.3 216.6 42.6 77.2 143.9 16.5 13.1 153.2 74.9 1.8 8.7 99.7 122.2 3.4 41.4 30.5 22.1 534.7 UGP2 "SVUGP2, UGP1, UGPP1" ENSG00000169764 "UDP-glucose pyrophosphorylase 2" Q16851 2 63840952-63891562 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Nucleotidyltransferase, Transferase" "Disease variant, Epilepsy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "liver: 858.6;tongue: 756.1" "Cell type enhanced" "Detected in all" "Distal enterocytes: 849.9;Hepatocytes: 559.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "basophil: 417.1" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA034696, HPA034697, HPA064836" Enhanced Approved Nucleoplasm,Centrosome,Mitochondria NA NA 13000000 "Cluster 38: Basophils - Unknown function" "Cluster 55: Non-specific - Mitochondria & Proteasome" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 30: Mammary glandular cells - Lactation" "Centrosome, Mitochondria" Nucleoplasm "HPA034696: AB_10670171, HPA034697: AB_2674287, HPA064836: AB_2685365" "unprognostic (1.00e-2)" "unprognostic (6.93e-2)" "unprognostic (5.12e-2)" "unprognostic (1.06e-1)" "unprognostic (2.65e-2)" "unprognostic (1.91e-1)" "prognostic favorable (2.50e-5)" "unprognostic (2.20e-1)" "unprognostic (3.01e-1)" "unprognostic (1.84e-1)" "unprognostic (1.57e-2)" "unprognostic (8.31e-2)" "unprognostic (1.03e-1)" "unprognostic (1.25e-2)" "unprognostic (3.93e-2)" "unprognostic (3.81e-1)" "unprognostic (8.44e-2)" 267.3 72.0 79.8 65.8 89.3 40.1 119.7 72.7 109.8 65.9 78.8 177.9 66.0 75.2 50.6 97.5 68.9 60.7 232.5 87.9 81.4 105.4 858.6 65.4 65.7 77.7 77.0 47.0 74.4 113.3 49.8 137.8 77.6 57.4 159.3 36.8 92.9 66.2 498.0 59.1 67.6 78.5 73.2 50.8 69.5 38.3 83.3 106.2 64.5 756.1 73.7 88.4 63.7 91.8 122.3 77.6 63.1 42.0 176.1 222.4 220.6 129.1 116.1 82.7 89.4 170.0 104.5 149.5 48.3 165.6 79.9 57.4 73.4 102.6 137.0 99.2 35.7 86.5 50.4 117.9 87.0 79.1 73.9 148.1 175.8 76.1 80.3 108.4 119.4 38.9 48.2 58.1 327.8 56.7 104.6 75.2 122.9 207.7 50.1 80.4 117.9 84.5 147.4 77.7 36.5 29.6 103.3 149.8 64.3 162.6 51.7 59.2 144.3 84.4 125.9 113.8 90.5 101.3 51.4 174.9 99.2 122.7 225.7 417.1 33.0 53.1 48.0 40.7 51.8 33.0 53.6 50.1 27.9 31.8 57.6 53.6 45.4 70.0 39.5 29.7 127.2 62.0 79.8 89.3 72.7 109.8 87.9 81.4 77.7 77.0 77.6 73.2 83.3 91.8 73.4 28.9 54.0 107.4 65.3 75.8 87.8 245.9 34.7 49.6 360.6 87.1 264.3 104.4 171.6 47.8 64.6 414.3 81.1 849.9 242.6 140.6 91.5 53.0 106.3 69.8 44.5 56.0 86.1 103.6 445.5 159.3 79.0 49.5 67.8 42.4 63.5 559.4 120.9 87.5 78.4 179.8 144.5 102.4 90.2 86.1 79.2 89.1 96.0 62.8 139.7 58.8 154.5 37.2 79.3 91.6 313.9 77.5 60.7 81.2 176.2 284.4 139.3 57.3 72.3 50.5 129.2 84.9 54.9 50.9 57.8 472.8 143.1 90.6 189.5 109.1 UGT1A1 "GNT1, UGT1, UGT1A" ENSG00000241635 "UDP glucuronosyltransferase family 1 member A1" P22309 2 233760270-233773300 "Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cancer-related genes, Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 26 "intestine: 201.2;liver: 322.4" "Cell type enriched" "Detected in some" 7 "Hepatocytes: 105.0" "Cancer enriched" "Detected in some" 19 "liver cancer: 16.4" "Low region specificity" "Detected in single" "Immune cell enhanced" "Detected in single" "neutrophil: 1.4" "Lineage enriched" "Detected in single" 4 "granulocytes: 1.4" "Cell line enhanced" "Detected in some" "HaCaT: 14.0;OE19: 64.5;RT4: 34.7" "Not detected" "Not detected" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 21: OE19 - Mitochondria" "Cluster 2: Hepatocytes - Metabolism" "unprognostic (7.28e-2)" "unprognostic (2.49e-2)" "unprognostic (3.60e-1)" "unprognostic (5.69e-2)" "unprognostic (4.17e-3)" "unprognostic (6.31e-3)" "unprognostic (1.94e-5)" "unprognostic (2.78e-3)" "unprognostic (2.99e-4)" 0.1 0.1 0.6 0.2 0.5 0.5 0.2 1.5 0.8 0.1 0.2 3.0 201.2 0.2 0.4 3.5 0.1 1.0 0.2 0.4 0.8 4.0 322.4 0.2 0.3 0.2 0.2 0.2 0.1 0.1 0.0 0.1 0.2 0.2 2.4 0.9 0.5 0.3 0.1 1.8 79.2 0.1 0.0 0.2 2.4 0.6 0.3 0.1 0.2 0.1 0.3 10.0 0.9 0.6 0.3 1.1 0.2 0.2 0.1 0.1 0.6 0.0 0.0 0.0 0.1 5.4 0.3 0.2 2.5 0.1 0.1 14.0 0.0 0.2 0.0 0.2 0.1 0.1 0.6 1.6 0.0 0.5 0.2 0.2 0.6 0.0 0.0 0.1 0.0 0.3 0.2 0.6 0.0 0.8 0.1 0.3 0.5 64.5 6.5 0.1 0.1 0.6 0.0 34.7 0.2 0.4 2.6 0.4 0.0 0.2 0.2 0.0 0.1 0.2 0.1 0.3 0.0 0.2 0.2 0.1 0.7 0.4 0.2 0.9 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.0 0.2 0.1 0.1 1.4 0.3 0.1 0.1 0.1 0.0 0.6 0.5 1.5 0.8 0.4 0.8 0.2 0.2 0.2 0.0 0.3 0.6 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.1 0.6 0.0 0.0 0.0 0.0 0.0 3.7 1.8 0.0 0.0 0.0 1.8 0.0 0.1 2.9 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 1.1 105.0 0.0 0.0 0.0 0.4 0.0 2.4 0.0 1.8 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 1.6 0.0 0.1 6.9 14.6 2.2 1.5 0.0 0.0 0.4 0.1 0.2 0.1 1.5 0.0 0.0 0.1 0.0 0.7 7.3 UGT1A10 UGT1J ENSG00000242515 "UDP glucuronosyltransferase family 1 member A10" Q9HAW8 2 233636454-233773305 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "gallbladder: 22.0;intestine: 79.5;stomach 1: 32.7" "Cell type enhanced" "Detected in some" "Distal enterocytes: 1.8;Gastric mucus-secreting cells: 3.6;Intestinal goblet cells: 1.0;Paneth cells: 1.4;Proximal enterocytes: 3.9;Squamous epithelial cells: 4.3" "Cancer enhanced" "Detected in many" "urothelial cancer: 9.7" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 143 "RT4: 523.3" "Intracellular and membrane" NA NA "Cluster 9: Intestine - Unknown function" "Cluster 15: RT4 - Unknown function" "Cluster 45: Enterocytes - Digestion" "unprognostic (9.33e-2)" "unprognostic (7.64e-2)" "unprognostic (2.45e-3)" "unprognostic (1.73e-1)" "prognostic unfavorable (4.55e-4)" "unprognostic (1.49e-10)" "unprognostic (2.90e-1)" "unprognostic (1.50e-1)" "unprognostic (3.59e-3)" 0.1 0.0 0.0 3.4 0.0 0.0 0.1 0.0 0.0 0.0 0.0 49.5 79.5 0.1 0.0 14.6 0.0 22.0 0.0 0.0 0.0 0.4 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 36.5 0.0 0.9 0.0 0.0 0.9 53.1 1.9 0.0 0.0 32.7 1.5 0.0 0.0 0.0 0.0 0.3 1.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 2.3 1.4 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 523.3 0.0 0.1 3.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.6 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.0 3.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.3 0.0 0.0 0.0 0.0 0.3 0.3 UGT1A3 UGT1C ENSG00000243135 "UDP glucuronosyltransferase family 1 member A3" P35503 2 233729108-233773299 "Cancer-related genes, Enzymes, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 14 "liver: 73.5" "Not detected" "Not detected" "Cancer enriched" "Detected in single" 6 "liver cancer: 2.1" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 6 "HaCaT: 11.4" NA NA "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 2: Hepatocytes - Metabolism" "unprognostic (5.15e-2)" "unprognostic (9.93e-2)" "unprognostic (2.97e-1)" "unprognostic (4.59e-2)" "unprognostic (1.04e-4)" "unprognostic (8.22e-2)" "unprognostic (2.08e-3)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 2.9 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.3 73.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.2 5.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 11.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.4 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 UGT1A4 "HUG-BR2, UGT1D" ENSG00000244474 "UDP glucuronosyltransferase family 1 member A4" P22310 2 233718736-233773300 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 68 "liver: 391.7" "Cell type enriched" "Detected in some" 6 "Hepatocytes: 15.1" "Cancer enriched" "Detected in single" 487 "liver cancer: 24.3" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 2: Hepatocytes - Metabolism" "unprognostic (9.89e-3)" "unprognostic (6.77e-5)" "unprognostic (2.59e-1)" "unprognostic (3.50e-3)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.7 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 391.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 2.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 UGT1A5 UGT1E ENSG00000240224 "UDP glucuronosyltransferase family 1 member A5" P35504 2 233712992-233773299 "Enzymes, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "gallbladder: 2.4;intestine: 7.4;liver: 1.7" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 56: Intestine - Transmembrane transport" "unprognostic (2.18e-3)" "unprognostic (1.36e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 7.4 0.0 0.0 0.1 0.0 2.4 0.0 0.0 0.0 0.1 1.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 6.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 UGT1A6 "GNT1, HLUGP, UGT1F" ENSG00000167165 "UDP glucuronosyltransferase family 1 member A6" P19224 2 233691607-233773300 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 6 "kidney: 71.3;liver: 143.3;urinary bladder: 88.8" "Cell type enhanced" "Detected in some" "Basal squamous epithelial cells: 12.5;Early spermatids: 52.4;Gastric mucus-secreting cells: 14.3;Late spermatids: 23.3;Squamous epithelial cells: 17.3" "Group enriched" "Detected in many" 5 "liver cancer: 7.2;lung cancer: 3.1;renal cancer: 7.6;urothelial cancer: 3.2" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 4 "OE19: 1194.0" "Not detected" "Not detected" "CAB009819, HPA054065, HPA056023" Enhanced Supported "Endoplasmic reticulum,Vesicles" NA NA "Cluster 85: Liver - Metabolism" "Cluster 21: OE19 - Mitochondria" "Cluster 34: Spermatids - Unknown function" Vesicles "Endoplasmic reticulum" "CAB009819: AB_2241481, HPA054065: AB_2682367, HPA056023: " "unprognostic (9.09e-2)" "unprognostic (6.07e-2)" "unprognostic (5.43e-2)" "unprognostic (6.03e-2)" "prognostic unfavorable (2.89e-6)" "unprognostic (2.79e-1)" "unprognostic (6.18e-2)" "unprognostic (2.09e-3)" "unprognostic (9.97e-2)" "unprognostic (2.16e-2)" "unprognostic (3.52e-1)" "unprognostic (7.50e-2)" "unprognostic (2.01e-2)" 0.1 0.0 0.0 0.1 0.0 0.0 0.8 0.0 0.0 1.8 0.0 1.8 5.8 0.1 2.6 16.1 0.0 3.5 0.0 0.0 0.0 71.3 143.3 0.6 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 1.1 1.3 0.0 2.6 3.6 0.0 11.1 2.6 0.0 0.0 0.0 17.4 0.4 0.0 1.2 0.5 0.0 5.8 88.8 5.5 0.0 4.2 1.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 53.8 1.6 0.0 80.2 0.1 0.8 294.5 0.1 4.0 0.0 0.0 0.0 0.0 0.3 1.3 0.0 0.0 0.3 0.0 31.2 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 6.2 0.0 0.0 0.0 1194.0 0.0 0.1 0.2 0.1 3.2 149.0 0.0 0.0 7.1 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 1.6 1.2 12.5 0.0 0.0 0.0 0.3 0.0 2.9 1.8 0.0 0.0 0.0 0.4 0.0 0.0 52.4 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 14.3 0.5 0.0 0.0 0.4 5.7 0.0 0.0 0.0 0.1 0.0 0.0 0.0 23.3 0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 1.9 0.5 1.8 0.1 0.0 0.0 0.0 0.0 1.2 0.2 17.3 1.1 0.0 0.0 0.0 0.1 3.0 UGT1A7 UGT1G ENSG00000244122 "UDP glucuronosyltransferase family 1 member A7" Q9HAW7 2 233681938-233773299 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 12 "esophagus: 83.8" "Cell type enriched" "Detected in some" 4 "Squamous epithelial cells: 40.7" "Group enriched" "Detected in some" 10 "cervical cancer: 1.2;head and neck cancer: 2.3;lung cancer: 3.0" "Low region specificity" "Detected in single" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 15 "SiHa: 112.2" NA NA "Cluster 84: Esophagus - Epithelial cell function" "Cluster 20: HeLa - Mitochondria" "Cluster 61: Squamous epithelial cells - Keratinization" "unprognostic (6.27e-2)" "unprognostic (1.02e-1)" "unprognostic (7.76e-2)" "unprognostic (1.03e-2)" "unprognostic (1.09e-1)" "unprognostic (7.92e-2)" "unprognostic (1.71e-7)" "unprognostic (2.14e-1)" "unprognostic (4.57e-2)" 0.1 1.3 0.2 0.0 0.2 0.0 0.4 0.5 0.8 1.2 0.4 0.3 0.2 0.0 0.0 83.8 0.0 0.0 0.0 0.3 0.2 0.7 4.3 0.0 0.0 0.2 0.5 0.0 0.0 0.0 0.0 0.0 0.2 0.1 0.1 0.1 5.6 0.0 0.0 3.6 0.1 0.0 0.1 0.0 0.1 0.0 0.3 0.0 0.0 0.0 5.2 0.4 7.1 1.0 0.0 1.8 0.1 0.0 0.8 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 1.3 0.0 0.0 112.2 7.5 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.2 0.5 0.8 0.3 0.2 0.2 0.5 0.2 0.1 0.3 1.0 0.0 0.0 0.0 0.0 0.0 0.4 2.3 1.3 4.6 0.0 0.0 0.0 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 2.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 2.8 0.7 0.3 0.2 0.0 0.0 0.0 0.2 0.0 0.0 40.7 1.7 0.0 0.0 0.0 0.5 8.5 UGT1A8 UGT1H ENSG00000242366 "UDP glucuronosyltransferase family 1 member A8" Q9HAW9 2 233617645-233773310 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "intestine: 15.9;liver: 20.1;urinary bladder: 30.0" "Cell type enhanced" "Detected in some" "Basal respiratory cells: 4.5;Club cells: 1.0;Ionocytes: 2.0;Paneth cells: 2.5;Proximal enterocytes: 1.3;Squamous epithelial cells: 1.1" "Cancer enriched" "Detected in some" 5 "urothelial cancer: 2.4" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 64 "RT4: 121.4" NA NA "Cluster 41: Intestine & Liver - Lipid metabolism" "Cluster 15: RT4 - Unknown function" "Cluster 26: Respiratory epithelial cells - Mucosal defense" "unprognostic (1.27e-2)" "unprognostic (1.35e-1)" "unprognostic (1.42e-3)" "unprognostic (1.23e-1)" "unprognostic (4.78e-1)" "unprognostic (9.71e-12)" "unprognostic (9.26e-2)" "unprognostic (1.96e-1)" 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.9 2.8 0.0 0.0 1.9 0.0 6.5 0.0 0.0 0.0 1.8 20.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 8.8 0.0 0.5 0.0 0.0 0.1 4.3 1.0 0.0 0.0 0.1 0.0 0.0 1.0 0.0 0.0 0.4 30.0 0.8 0.0 0.0 0.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.1 0.0 0.0 0.0 0.0 121.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 4.5 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.5 0.0 0.0 0.0 1.3 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.6 0.0 0.0 0.0 0.4 0.2 UGT1A9 "HLUGP4, LUGP4, UGT1AI" ENSG00000241119 "UDP glucuronosyltransferase family 1 member A9" O60656 2 233671898-233773300 "Cancer-related genes, Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Cancer-related genes" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 370 "kidney: 458.6;liver: 195.6" "Group enriched" "Detected in some" 11 "Hepatocytes: 7.5;Proximal tubular cells: 6.6" "Group enriched" "Detected in some" 157 "liver cancer: 16.1;renal cancer: 16.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 13 "A549: 1.4;RT4: 1.2" NA NA "Cluster 81: Kidney & Liver - Metabolism" "Cluster 15: RT4 - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "unprognostic (2.46e-2)" "unprognostic (3.56e-1)" "prognostic unfavorable (5.04e-5)" "unprognostic (4.26e-2)" "unprognostic (1.60e-1)" 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 458.6 195.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 7.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 6.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 UGT2A1 ENSG00000173610 "UDP glucuronosyltransferase family 2 member A1 complex locus" P0DTE4 4 69588417-69653249 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Olfaction, Sensory transduction" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 5 "choroid plexus: 3.6;kidney: 2.3;liver: 3.6;pituitary gland: 5.6" "Cell type enriched" "Detected in some" 18 "Proximal tubular cells: 107.9" "Cancer enhanced" "Detected in some" "liver cancer: 0.7;lung cancer: 0.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "HPA017261, HPA045108" Uncertain NA NA "Cluster 88: Choroid plexus - Transmembrane transport" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA017261: AB_10963582, HPA045108: AB_2679218" "unprognostic (3.93e-3)" "unprognostic (5.62e-1)" "unprognostic (1.28e-4)" "unprognostic (1.74e-1)" "unprognostic (2.76e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 2.3 3.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 1.5 0.0 3.7 0.0 0.0 0.0 0.0 5.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 107.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 UGT2A2 ENSG00000271271 "UDP glucuronosyltransferase family 2 member A2" "P0DTE4, P0DTE5" 4 69588417-69639642 "Enzymes, Predicted membrane proteins" "Olfaction, Sensory transduction" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 9 "kidney: 6.3;liver: 10.0" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045108 Uncertain NA NA "Cluster 81: Kidney & Liver - Metabolism" "HPA045108: AB_2679218" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.3 10.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 UGT2A3 FLJ21934 ENSG00000135220 "UDP glucuronosyltransferase family 2 member A3" Q6UWM9 4 68928463-68951804 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 7 "intestine: 31.4;kidney: 21.0;liver: 13.3;pancreas: 16.3" "Cell type enhanced" "Detected in some" "Cholangiocytes: 91.5;Distal enterocytes: 89.8;Hepatocytes: 53.5;Paneth cells: 54.7;Proximal enterocytes: 248.9;Proximal tubular cells: 130.8;Undifferentiated cells: 101.1" "Cancer enriched" "Detected in many" 5 "renal cancer: 46.9" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 59 "Hep G2: 5.8" "Not detected" "Not detected" "Low region specificity" "Detected in all" HPA045108 Supported NA NA "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 45: Enterocytes - Digestion" "HPA045108: AB_2679218" "prognostic favorable (3.31e-4)" "unprognostic (3.97e-3)" "unprognostic (8.87e-3)" "prognostic favorable (6.07e-7)" "unprognostic (2.10e-2)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 22.7 9.4 0.0 0.0 0.0 0.0 2.8 0.0 0.0 0.0 21.0 13.3 0.0 0.0 0.0 0.0 0.0 16.3 0.0 0.0 0.0 0.0 0.0 9.3 0.0 0.0 0.0 0.0 0.0 31.4 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 5.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 91.5 0.0 3.7 0.0 0.0 0.0 89.8 11.7 26.3 0.0 0.0 0.0 0.0 12.2 2.7 0.0 2.8 0.0 0.0 0.0 0.0 0.0 0.0 0.4 53.5 0.0 0.0 0.0 34.0 0.0 1.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 6.1 54.7 0.0 0.0 0.0 248.9 130.8 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.1 0.0 101.1 0.0 UGT2B10 ENSG00000109181 "UDP glucuronosyltransferase family 2 member B10" P36537 4 68815994-68832023 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 149 "liver: 233.7" "Cell type enriched" "Detected in some" 11 "Hepatocytes: 245.3" "Cancer enriched" "Detected in single" 296 "liver cancer: 93.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 116 "Hep G2: 12.0" HPA045108 Uncertain NA NA "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 2: Hepatocytes - Metabolism" "HPA045108: AB_2679218" "unprognostic (3.50e-3)" "unprognostic (1.92e-3)" "unprognostic (4.17e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.0 233.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 12.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.6 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 21.0 0.1 0.0 0.3 0.0 10.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.4 245.3 0.0 0.0 0.0 0.3 0.0 7.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.4 0.0 0.2 0.0 UGT2B11 ENSG00000213759 "UDP glucuronosyltransferase family 2 member B11" O75310 4 69199951-69214748 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 21 "breast: 239.4" "Group enriched" "Detected in some" 4 "Breast glandular cells: 13.7;Cholangiocytes: 7.2" "Group enriched" "Detected in some" 17 "breast cancer: 17.4;liver cancer: 13.1" "Not detected" "Not detected" "Group enriched" "Detected in some" 42 "basophil: 4.7;eosinophil: 3.5" "Lineage enriched" "Detected in single" 47 "granulocytes: 4.7" "Not detected" "Not detected" HPA045108 Uncertain NA NA "Cluster 46: Basophils - DNA binding" "Cluster 5: Breast - Unknown function" "Cluster 35: Glandular cells - Unknown function" "HPA045108: AB_2679218" "unprognostic (1.12e-1)" "unprognostic (1.18e-3)" "unprognostic (1.49e-1)" "unprognostic (6.53e-2)" "unprognostic (2.26e-2)" "unprognostic (1.65e-1)" "unprognostic (7.84e-3)" "unprognostic (5.47e-1)" "unprognostic (1.32e-1)" "unprognostic (1.51e-3)" 0.1 0.0 0.0 0.1 0.0 0.1 239.4 0.0 0.0 0.1 0.0 0.1 0.7 0.0 0.9 0.0 0.5 11.4 0.0 0.0 0.0 3.6 9.8 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.6 0.1 0.0 0.4 0.5 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.1 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 4.7 0.0 3.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.7 0.5 0.0 7.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.3 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.1 UGT2B15 UGT2B8 ENSG00000196620 "UDP glucuronosyltransferase family 2 member B15" P54855 4 68646597-68670652 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Lipid metabolism, Steroid metabolism" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 9 "gallbladder: 77.7;liver: 291.2" "Group enriched" "Detected in some" 6 "Cholangiocytes: 168.7;Hepatocytes: 142.8" "Cancer enriched" "Detected in many" 10 "liver cancer: 120.2" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" HPA045108 Uncertain NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 60: Liver - Hemostasis & Lipid metabolism" "Cluster 2: Hepatocytes - Metabolism" "HPA045108: AB_2679218" "unprognostic (1.40e-1)" "unprognostic (2.25e-1)" "unprognostic (2.22e-2)" "unprognostic (3.86e-1)" "unprognostic (1.94e-1)" "prognostic favorable (9.82e-4)" "unprognostic (6.73e-2)" "unprognostic (3.49e-2)" "unprognostic (7.84e-2)" "unprognostic (5.81e-3)" "unprognostic (2.39e-2)" "unprognostic (5.38e-2)" "prognostic favorable (4.50e-4)" 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 21.6 5.1 0.0 0.0 0.0 0.1 77.7 0.0 0.0 0.0 0.0 291.2 0.0 0.0 0.0 0.0 0.0 12.9 0.0 0.0 0.0 0.0 0.0 0.8 0.0 0.1 0.0 0.0 0.0 13.0 0.0 0.0 0.1 17.0 0.5 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.2 0.2 0.0 0.0 4.4 0.9 0.1 168.7 0.1 0.0 0.0 0.0 0.0 0.3 0.0 24.2 3.0 0.2 0.0 0.2 0.0 2.7 0.1 3.6 0.1 0.1 0.0 0.0 0.0 0.0 2.9 142.8 0.0 0.0 0.1 3.3 0.0 3.2 0.0 0.6 0.0 0.4 0.0 0.0 0.6 0.0 0.0 0.0 0.0 14.6 1.1 0.0 0.0 0.2 0.4 0.0 0.0 0.0 0.0 0.9 0.1 0.6 1.0 0.0 0.0 0.0 0.4 0.0 0.5 0.9 UGT2B17 ENSG00000197888 "UDP glucuronosyltransferase family 2 member B17" O75795 4 68537184-68568527 "Enzymes, Human disease related genes, Metabolic proteins, Predicted membrane proteins" "Lipid metabolism, Steroid metabolism" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 8 "intestine: 460.0;liver: 136.2" "Group enriched" "Detected in some" 6 "Distal enterocytes: 130.1;Paneth cells: 35.1;Undifferentiated cells: 100.6" "Group enriched" "Detected in many" 7 "colorectal cancer: 16.3;liver cancer: 10.1" "Not detected" "Not detected" "Group enriched" "Detected in some" 40 "memory B-cell: 2.8;naive B-cell: 8.8" "Lineage enriched" "Detected in single" 61 "B-cells: 8.8" "Cell line enhanced" "Detected in some" "BEWO: 1.0;NB-4: 1.1;RPMI-8226: 1.7" HPA045108 Supported NA NA "Cluster 21: B-cells - Adaptive immune response" "Cluster 9: Intestine - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" "HPA045108: AB_2679218" "unprognostic (1.66e-1)" "unprognostic (2.97e-2)" "unprognostic (2.96e-2)" "unprognostic (2.41e-1)" "unprognostic (1.88e-1)" "unprognostic (1.19e-2)" "unprognostic (2.36e-1)" "unprognostic (8.44e-3)" "unprognostic (9.67e-2)" "unprognostic (4.80e-3)" "unprognostic (8.52e-2)" "unprognostic (2.45e-1)" "unprognostic (6.44e-2)" "unprognostic (1.75e-1)" "unprognostic (1.76e-1)" 0.3 0.0 0.0 38.8 0.0 0.0 0.7 0.0 0.0 1.5 0.0 365.7 364.3 1.4 1.5 0.1 0.2 0.6 0.0 0.0 0.0 0.2 136.2 0.2 1.5 0.3 0.0 0.0 0.5 0.0 0.0 0.0 0.2 0.1 125.8 0.0 0.2 0.7 0.0 0.0 460.0 9.1 0.1 0.6 0.8 0.0 0.1 0.4 0.0 0.0 2.2 0.4 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.0 0.0 1.7 0.0 0.0 0.1 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 2.8 0.0 0.0 0.0 8.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.1 0.1 0.1 0.0 0.0 1.3 0.0 1.1 0.0 0.0 0.4 0.0 0.0 0.2 0.1 0.0 1.5 0.6 0.0 0.0 0.0 0.0 130.1 0.0 0.0 0.0 11.1 0.1 0.0 1.8 0.0 0.2 0.0 0.1 0.0 0.0 1.0 0.0 0.0 0.4 2.8 0.0 0.0 0.1 13.8 0.0 0.0 0.0 0.0 0.0 0.0 3.6 0.0 0.0 0.0 0.0 0.5 0.3 0.1 35.1 0.0 1.0 0.0 0.0 0.1 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.5 0.0 100.6 0.2 UGT2B28 ENSG00000135226 "UDP glucuronosyltransferase family 2 member B28" Q9BY64 4 69280475-69295050 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 14 "breast: 198.5" "Cell type enriched" "Detected in single" 16 "Cholangiocytes: 10.0" "Cancer enriched" "Detected in single" 8 "breast cancer: 1.9" "Not detected" "Not detected" "Immune cell enhanced" "Detected in single" "eosinophil: 1.3" "Lineage enriched" "Detected in single" 13 "granulocytes: 1.3" "Group enriched" "Detected in some" 10 "Daudi: 2.9;NB-4: 2.7" HPA045108 Uncertain "Intracellular and membrane" NA NA "Cluster 2: Granulocytes - Unknown function" "Cluster 5: Breast - Unknown function" "Cluster 24: NB-4 - Immune response" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA045108: AB_2679218" "unprognostic (1.81e-1)" "unprognostic (1.40e-1)" "unprognostic (7.20e-3)" "unprognostic (1.51e-2)" "unprognostic (4.37e-5)" "unprognostic (9.79e-4)" 0.0 0.0 0.0 0.0 0.0 0.0 198.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.1 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 2.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.8 0.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.1 10.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 UGT2B4 UGT2B11 ENSG00000156096 "UDP glucuronosyltransferase family 2 member B4" P06133 4 69480165-69526014 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 107 "liver: 1273.7" "Cell type enriched" "Detected in some" 22 "Hepatocytes: 883.5" "Cancer enriched" "Detected in some" 96 "liver cancer: 351.5" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 9 "RH-30: 4.6" "CAB033260, HPA045108" Enhanced "Intracellular and membrane" NA NA "Cluster 62: Liver - Hemostasis" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 2: Hepatocytes - Metabolism" "CAB033260: AB_2241496, HPA045108: AB_2679218" "unprognostic (7.46e-2)" "unprognostic (1.50e-1)" "unprognostic (9.37e-2)" "unprognostic (1.51e-1)" "unprognostic (2.47e-2)" "unprognostic (1.47e-1)" "unprognostic (9.43e-3)" "unprognostic (3.52e-1)" 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 11.9 0.0 0.0 1.3 1273.7 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.2 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.3 0.0 0.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 4.6 0.0 0.1 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.0 39.4 12.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 1.1 0.0 10.7 0.1 0.0 0.0 1.2 0.0 0.0 0.0 0.0 11.7 883.5 0.1 0.0 0.1 0.0 0.0 15.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.1 0.0 0.0 0.0 0.0 0.0 0.0 2.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.9 0.1 0.0 0.0 UGT2B7 UGT2B9 ENSG00000171234 "UDP glucuronosyltransferase family 2 member B7" P16662 4 69051363-69112987 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Lipid metabolism, Steroid metabolism" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 21 "kidney: 1299.8;liver: 1612.1" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 150.6;Glandular and luminal cells: 234.7;Hepatocytes: 550.8;Proximal tubular cells: 1249.5" "Group enriched" "Detected in many" 7 "liver cancer: 116.4;renal cancer: 101.8" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in some" 4 "RPTEC TERT1: 310.8" HPA045108 Uncertain NA NA "Cluster 81: Kidney & Liver - Metabolism" "Cluster 35: RPTEC-TERT1 - Kidney processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "HPA045108: AB_2679218" "unprognostic (1.04e-1)" "unprognostic (1.65e-1)" "prognostic favorable (7.65e-5)" "unprognostic (1.11e-2)" "unprognostic (2.10e-1)" "unprognostic (2.30e-2)" "unprognostic (5.41e-3)" "unprognostic (1.68e-1)" "unprognostic (1.74e-2)" "unprognostic (1.17e-3)" "unprognostic (1.98e-1)" "prognostic favorable (3.79e-4)" "unprognostic (1.08e-2)" "unprognostic (2.55e-1)" "unprognostic (6.23e-3)" "prognostic favorable (5.38e-4)" 0.2 0.0 0.0 0.3 0.0 0.0 2.3 0.0 0.0 32.0 0.0 3.8 68.7 8.9 24.2 0.2 49.9 10.4 0.0 0.0 0.0 1299.8 1612.1 0.4 0.0 0.0 0.0 0.1 9.9 0.0 0.0 0.1 0.0 0.3 6.9 0.0 3.6 27.5 0.0 0.3 66.6 0.3 0.0 0.0 0.9 0.1 0.0 0.9 0.0 0.0 0.2 1.6 0.0 0.0 0.0 0.3 0.2 0.3 0.0 0.0 0.2 0.0 2.5 0.0 0.0 0.3 0.0 0.0 77.6 0.0 0.0 0.0 0.0 0.1 0.0 1.0 0.0 0.1 0.0 41.9 0.0 0.8 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 2.3 0.0 0.1 0.6 0.1 310.8 2.7 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 43.2 0.0 0.0 0.0 0.2 0.3 0.2 3.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.7 0.1 0.6 1.6 0.0 0.0 1.2 0.6 0.1 38.6 2.1 125.0 0.0 0.0 0.0 5.7 97.8 6.6 0.3 150.6 14.0 1.0 3.5 2.7 0.4 10.6 0.0 0.1 0.0 234.7 0.0 0.0 8.9 550.8 0.1 0.0 0.3 37.3 0.0 13.8 0.0 0.0 1.8 7.6 3.6 0.0 0.0 0.0 0.0 1.5 0.4 13.0 10.7 0.0 0.0 0.6 70.6 1249.5 0.5 0.0 0.0 0.0 0.6 0.0 0.2 0.0 0.1 0.0 6.3 0.1 5.9 2.3 UGT3A1 FLJ34658 ENSG00000145626 "UDP glycosyltransferase family 3 member A1" Q6NUS8 5 35951006-36001028 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Group enriched" "Detected in some" 6 "kidney: 51.1;liver: 58.0" "Cell type enhanced" "Detected in some" "Collecting duct cells: 49.7;Early spermatids: 125.9;Hepatocytes: 72.1;Late spermatids: 24.5;Proximal tubular cells: 87.0" "Group enriched" "Detected in some" 15 "liver cancer: 6.7;renal cancer: 4.3" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 42 "RH-30: 28.2" "HPA047697, HPA056290" Uncertain Approved Vesicles,Cytosol NA NA "Cluster 81: Kidney & Liver - Metabolism" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Vesicles, Cytosol" "HPA047697: AB_2680122, HPA056290: AB_2683088" "unprognostic (2.41e-3)" "unprognostic (4.47e-1)" "unprognostic (4.04e-1)" "unprognostic (4.62e-1)" "unprognostic (1.42e-2)" "unprognostic (6.05e-2)" "unprognostic (9.14e-2)" "unprognostic (1.76e-1)" 0.0 0.0 0.1 0.0 0.1 0.0 0.1 0.0 0.4 0.0 0.0 0.0 9.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 51.1 58.0 0.0 0.0 0.1 0.0 0.2 0.0 0.4 0.2 0.0 0.1 0.3 0.0 0.7 0.1 0.2 3.0 0.0 6.7 0.0 0.0 0.0 0.0 5.6 0.0 0.0 0.1 2.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.1 0.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 28.2 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.4 0.1 0.0 0.1 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 4.1 0.0 0.0 0.4 0.0 0.0 49.7 0.0 0.0 0.0 0.0 3.9 0.0 125.9 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.2 0.0 0.0 1.8 72.1 0.1 0.0 0.3 0.7 0.0 2.6 0.0 24.5 0.9 0.6 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 2.5 0.4 0.0 0.0 3.8 87.0 0.0 0.2 6.6 0.0 0.0 4.4 0.8 0.0 0.0 0.0 0.5 0.0 1.8 0.1 UGT3A2 ENSG00000168671 "UDP glycosyltransferase family 3 member A2" Q3SY77 5 36035021-36071358 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "bone marrow: 6.5;lymphoid tissue: 14.7;skin 1: 10.3" "Group enriched" "Detected in some" 4 "Collecting duct cells: 3.7;Early spermatids: 4.4;Late spermatids: 8.2;Proximal tubular cells: 3.8" "Cancer enriched" "Detected in some" 5 "testis cancer: 4.4" "Low region specificity" "Detected in some" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HDLM-2: 6.8;JURKAT: 6.3;MOLT-4: 12.4;REH: 29.9;SuSa: 11.8;T-47d: 7.2;THP-1: 18.0" "Low region specificity" "Detected in many" HPA059475 Uncertain Approved "Nucleoplasm,Golgi apparatus,Cytosol" Yes NA "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 14: REH - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm "Golgi apparatus, Cytosol" "HPA059475: AB_2684031" "unprognostic (1.83e-4)" "unprognostic (9.94e-2)" "unprognostic (8.87e-2)" "unprognostic (4.82e-4)" "unprognostic (3.18e-1)" "unprognostic (3.52e-2)" "unprognostic (1.56e-1)" "unprognostic (6.08e-2)" "unprognostic (2.04e-1)" "unprognostic (8.13e-2)" "unprognostic (7.49e-2)" "unprognostic (4.17e-2)" "unprognostic (1.36e-3)" "unprognostic (6.65e-2)" "unprognostic (7.52e-2)" "unprognostic (7.38e-2)" "unprognostic (4.52e-3)" 0.0 0.8 0.0 0.0 0.0 6.5 1.1 0.3 0.1 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.1 0.1 0.0 0.3 2.6 0.6 0.0 0.0 1.0 1.1 0.0 0.0 0.1 0.9 0.2 1.2 0.4 0.0 0.1 0.1 0.0 0.1 10.3 0.0 0.0 0.1 1.2 0.1 2.9 0.6 14.7 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.6 1.8 0.0 0.1 0.0 0.0 0.3 0.4 0.0 1.3 0.0 0.5 6.8 4.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 6.3 0.0 0.0 0.0 0.0 12.4 0.0 5.3 0.0 0.0 29.9 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.8 7.2 18.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.1 0.0 0.3 1.0 1.1 1.2 0.1 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.3 0.2 0.0 0.0 3.7 0.0 0.2 0.0 0.0 0.0 0.0 4.4 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.6 0.7 0.0 0.0 0.0 0.1 0.0 0.7 0.1 0.0 0.1 0.0 0.0 0.0 1.1 8.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.5 0.2 0.0 0.0 0.0 0.3 0.1 0.0 3.8 0.0 0.0 0.0 0.0 0.0 0.3 0.9 0.0 0.0 0.3 0.0 0.1 0.0 0.0 UGT8 CGT ENSG00000174607 "UDP glycosyltransferase 8" Q16880 4 114598770-114678225 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Lipid metabolism, Sphingolipid metabolism" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in many" 9 "brain: 266.4" "Cell type enriched" "Detected in many" 8 "Oligodendrocytes: 821.1" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 10 "memory B-cell: 6.9;naive B-cell: 10.7" "Lineage enriched" "Detected in single" 12 "B-cells: 10.7" "Cell line enhanced" "Detected in many" "CAPAN-2: 58.4;OE19: 123.7;RPTEC TERT1: 55.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA014405, HPA065785" Enhanced Approved Mitochondria No No "Cluster 19: B-cells - Humoral immune response" "Cluster 70: Brain - Nervous system development" "Cluster 21: OE19 - Mitochondria" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Mitochondria "HPA014405: AB_1858606, HPA065785: AB_2685559" "unprognostic (7.38e-3)" "unprognostic (2.07e-1)" "unprognostic (1.25e-2)" "unprognostic (2.38e-1)" "unprognostic (1.63e-1)" "unprognostic (1.63e-2)" "unprognostic (1.16e-2)" "unprognostic (2.38e-1)" "unprognostic (7.78e-2)" "unprognostic (1.56e-3)" "unprognostic (4.49e-2)" "unprognostic (2.76e-1)" "prognostic favorable (8.55e-5)" "unprognostic (2.80e-1)" "unprognostic (1.78e-2)" "unprognostic (7.53e-2)" "unprognostic (1.49e-1)" 0.6 0.6 58.6 4.6 153.7 1.1 4.6 166.2 94.5 7.0 9.7 26.8 30.3 3.8 0.3 1.5 4.4 11.0 0.3 66.2 94.7 31.0 0.2 1.1 4.9 220.9 132.8 0.4 8.5 0.2 0.2 0.2 200.6 0.5 27.7 2.2 7.3 0.7 0.5 2.2 27.7 1.6 139.2 1.7 16.8 5.0 132.4 0.6 13.5 0.4 5.0 0.6 0.6 266.4 0.6 0.2 4.4 0.6 0.3 0.0 0.7 0.2 0.0 0.1 3.4 17.7 58.4 17.6 1.2 0.2 13.8 25.8 0.0 0.1 0.1 0.3 14.3 0.3 24.6 0.0 0.0 0.4 0.4 0.0 0.0 0.1 0.0 5.4 0.1 0.2 16.1 3.0 0.1 0.3 0.3 1.7 6.4 123.7 8.8 1.6 28.9 0.3 55.2 0.6 31.4 4.6 0.2 5.4 0.8 1.1 0.9 5.4 1.0 1.1 19.2 0.7 19.6 6.3 0.8 0.6 29.2 0.9 17.9 0.2 0.0 0.8 0.0 0.0 0.6 6.9 0.0 0.0 0.0 10.7 0.2 0.1 0.1 0.0 0.0 0.0 0.0 0.3 58.6 153.7 166.2 94.5 66.2 94.7 220.9 132.8 200.6 139.2 132.4 266.4 0.1 6.4 1.5 1.0 22.0 0.0 1.8 0.3 6.8 0.0 5.7 6.1 0.8 8.6 3.9 25.8 0.0 0.0 0.1 19.0 9.8 1.4 9.2 9.6 1.7 0.5 48.4 0.0 1.0 13.1 0.0 0.6 19.4 21.4 0.0 0.2 0.0 0.0 0.0 0.0 3.7 27.9 0.0 0.0 0.0 3.5 1.2 0.5 1.8 2.8 0.0 0.0 0.0 98.5 821.1 10.8 14.6 0.0 4.0 0.7 24.2 1.4 1.5 0.0 0.0 0.0 0.4 20.9 34.0 5.9 0.1 0.0 0.4 0.1 26.9 0.9 UHMK1 "KIS, Kist" ENSG00000152332 "U2AF homology motif kinase 1" Q8TAS1 1 162497251-162529631 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, RNA-binding, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA077624 Supported "Nucleoplasm,Nuclear speckles,Vesicles" NA No "Cluster 51: Monocytes - Innate immune response" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 59: Non-specific - Transcription" "Nucleoplasm, Nuclear speckles" Vesicles "HPA077624: " "unprognostic (6.69e-2)" "unprognostic (1.28e-1)" "unprognostic (1.05e-1)" "unprognostic (1.46e-1)" "unprognostic (1.28e-1)" "unprognostic (1.33e-1)" "unprognostic (2.08e-2)" "unprognostic (8.16e-2)" "unprognostic (9.63e-2)" "unprognostic (1.82e-1)" "unprognostic (7.81e-3)" "unprognostic (9.10e-2)" "unprognostic (3.11e-1)" "unprognostic (3.44e-2)" "unprognostic (9.08e-2)" "unprognostic (8.77e-2)" "unprognostic (4.66e-2)" 26.8 23.3 21.2 23.3 24.6 40.3 19.3 18.1 21.2 15.1 16.6 19.2 19.1 11.7 14.1 13.3 14.4 13.7 11.6 26.0 28.3 31.2 38.1 17.5 30.8 24.9 28.5 11.9 11.0 27.8 7.8 17.1 28.3 16.2 19.6 10.5 13.5 18.5 25.8 11.9 23.4 10.8 19.8 25.4 20.0 12.2 26.1 24.6 19.4 25.9 28.9 18.1 10.5 19.4 61.9 28.4 14.6 35.8 40.7 31.9 32.7 79.7 43.2 63.9 45.7 18.6 37.8 50.2 67.8 60.0 31.2 34.9 28.2 44.1 102.4 69.1 20.4 49.8 34.3 16.9 31.3 73.4 55.5 33.0 45.8 63.2 59.9 44.6 37.4 34.2 44.1 67.7 111.4 26.0 39.3 19.4 19.4 46.1 37.8 24.9 64.9 41.9 42.6 62.8 26.4 24.3 70.5 64.6 52.2 19.9 56.0 81.0 58.5 72.7 41.0 50.8 112.6 69.2 103.5 58.0 60.5 35.3 67.3 3.6 2.0 2.4 4.8 5.3 4.9 3.2 3.5 4.0 2.3 3.6 3.5 4.0 1.3 3.7 6.1 2.6 3.1 2.6 21.2 24.6 18.1 21.2 26.0 28.3 24.9 28.5 28.3 19.8 26.1 19.4 37.6 19.2 41.2 20.9 75.6 29.4 33.7 38.5 34.7 24.4 39.4 20.2 35.1 40.0 53.8 53.3 12.5 26.2 81.0 53.9 56.7 27.6 55.6 35.1 35.7 33.4 33.5 51.6 37.0 23.2 38.1 25.5 43.3 44.4 45.7 23.3 31.1 85.1 30.0 23.5 27.4 34.1 48.8 73.5 47.5 58.4 21.5 60.0 28.4 33.7 58.0 14.6 74.2 20.6 29.5 40.4 33.0 19.5 47.2 59.9 60.8 62.2 50.9 23.0 0.0 29.2 27.8 25.1 29.6 45.2 24.6 22.4 69.4 31.4 39.3 58.3 UHRF1 "FLJ21925, ICBP90, Np95, RNF106, TDRD22" ENSG00000276043 "Ubiquitin like with PHD and ring finger domains 1" Q96T88 19 4903080-4962154 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, DNA damage, DNA repair, Transcription, Transcription regulation, Ubl conjugation pathway" "Chromatin regulator, DNA-binding, Repressor, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in many" 7 "bone marrow: 27.0;lymphoid tissue: 67.2" "Cell type enhanced" "Detected in many" "Erythroid cells: 49.7;Plasma cells: 21.0;Squamous epithelial cells: 15.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "plasmacytoid DC: 4.8" "Group enriched" "Detected in many" 4 "dendritic cells: 4.8;T-cells: 2.3" "Cell line enhanced" "Detected in all" "MOLT-4: 450.9;REH: 1004.5" "Low region specificity" "Detected in many" "Low region specificity" "Detected in many" "HPA049408, HPA055446" Enhanced Supported Nucleoplasm No Yes "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 53: Non-specific - Cell cycle regulation" "Cluster 14: REH - Unknown function" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm "HPA049408: AB_2756317, HPA055446: AB_2732597" "unprognostic (3.83e-2)" "unprognostic (6.83e-3)" "unprognostic (5.13e-2)" "unprognostic (1.69e-1)" "unprognostic (1.40e-1)" "unprognostic (7.21e-2)" "prognostic unfavorable (1.63e-4)" "unprognostic (4.30e-2)" "prognostic unfavorable (6.81e-4)" "unprognostic (2.82e-1)" "prognostic unfavorable (4.52e-5)" "unprognostic (2.33e-3)" "unprognostic (0.00e+0)" "unprognostic (3.75e-3)" "unprognostic (2.45e-1)" "unprognostic (2.01e-1)" "unprognostic (2.02e-1)" 1.0 0.9 2.1 9.6 2.7 27.0 1.7 2.1 2.3 1.6 1.8 2.9 3.7 1.0 0.1 6.5 0.4 0.8 0.5 2.0 2.2 0.6 0.9 1.3 15.8 2.8 2.8 0.3 0.6 0.2 0.2 2.1 2.7 0.6 2.6 0.4 1.5 0.2 1.2 3.4 3.9 1.9 1.9 3.7 3.3 5.2 3.5 67.2 0.3 0.3 10.3 1.6 2.5 4.6 111.3 78.7 116.6 83.4 3.3 13.3 18.5 88.3 42.0 89.9 86.8 94.6 54.9 62.7 21.1 39.4 32.7 54.1 81.2 47.7 63.0 102.7 92.2 54.3 74.3 102.4 1.3 135.1 78.9 6.5 3.5 48.9 12.6 14.1 27.2 97.2 79.3 70.5 54.5 86.7 450.9 82.5 52.5 40.0 84.3 1004.5 259.7 45.4 24.9 80.1 86.0 68.5 69.2 37.7 12.1 18.8 68.2 127.6 34.2 94.6 76.7 124.3 108.3 29.8 33.1 183.5 54.8 129.7 123.3 0.3 0.2 0.1 0.6 0.0 0.0 0.2 0.8 1.0 1.3 0.1 0.2 0.8 0.8 0.5 0.2 4.8 2.3 0.6 2.1 2.7 2.1 2.3 2.0 2.2 2.8 2.8 2.7 1.9 3.5 4.6 0.2 0.0 0.0 1.6 2.1 0.0 0.8 0.0 3.4 2.5 4.4 2.8 4.3 1.5 0.6 0.0 0.0 6.6 6.9 2.6 0.0 2.2 2.9 1.3 1.8 2.2 0.0 49.7 0.4 0.4 7.8 4.7 8.6 2.4 0.0 10.4 0.4 0.7 8.9 3.3 0.4 2.3 0.0 1.9 0.0 1.8 0.6 3.8 0.0 0.0 2.0 0.6 1.0 3.0 1.3 4.2 1.9 0.4 21.0 0.6 1.4 0.2 0.7 0.7 0.0 1.2 6.1 6.1 11.9 15.8 0.0 1.4 3.7 1.5 8.3 1.3 UHRF2 "MGC33463, NIRF, RNF107, TDRD23, URF2" ENSG00000147854 "Ubiquitin like with PHD and ring finger domains 2" Q96PU4 9 6413151-6507054 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Cell cycle, Ubl conjugation pathway" "DNA-binding, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 78.6" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA026633, HPA026697" Enhanced Nucleoplasm NA NA "Cluster 46: Basophils - DNA binding" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 43: Cardiomyocytes - Nuclear processes" Nucleoplasm "HPA026633: AB_2732431, HPA026697: AB_2732432" "unprognostic (1.08e-1)" "unprognostic (1.13e-1)" "unprognostic (1.52e-1)" "unprognostic (1.68e-1)" "unprognostic (1.12e-1)" "unprognostic (8.40e-2)" "unprognostic (4.35e-3)" "unprognostic (4.12e-2)" "unprognostic (1.53e-1)" "unprognostic (4.17e-2)" "unprognostic (1.73e-1)" "unprognostic (5.69e-3)" "unprognostic (2.14e-2)" "unprognostic (6.21e-2)" "unprognostic (8.77e-2)" "unprognostic (7.42e-2)" "unprognostic (1.50e-1)" 10.0 8.1 8.2 9.9 10.3 44.6 9.7 14.9 10.4 12.9 10.4 11.6 6.2 12.9 10.0 8.3 9.9 7.9 7.2 8.7 9.2 8.1 7.9 7.8 17.3 9.4 8.6 12.4 10.7 9.7 5.4 12.1 9.4 15.3 9.2 9.2 8.5 12.6 11.0 7.7 8.5 14.0 8.8 10.4 8.3 8.4 10.0 21.2 8.1 11.9 16.6 11.4 10.1 14.3 18.1 18.8 26.7 11.9 21.4 30.7 20.5 43.9 23.4 23.7 41.2 12.4 12.0 26.9 9.2 19.2 21.8 11.9 24.6 22.5 36.0 53.6 14.9 46.3 36.2 19.7 17.8 19.3 16.1 13.5 14.1 18.4 44.5 44.4 93.2 25.4 5.1 24.0 56.0 5.9 37.0 79.2 10.8 24.8 14.8 43.1 12.4 8.7 17.2 11.3 24.8 9.4 16.6 11.0 25.6 32.1 14.0 41.9 78.6 25.2 10.0 11.0 34.4 7.2 23.2 30.4 12.4 18.2 10.2 4.0 0.5 2.7 1.2 0.5 0.8 1.8 1.8 1.0 0.3 2.9 1.0 1.2 0.5 0.6 0.9 1.2 1.9 0.6 8.2 10.3 14.9 10.4 8.7 9.2 9.4 8.6 9.4 8.8 10.0 14.3 27.5 6.4 14.4 24.2 33.9 21.5 10.2 6.2 12.0 22.0 13.8 13.1 59.0 4.3 8.4 12.9 31.3 13.2 31.3 9.1 1.9 5.2 23.6 12.8 22.9 24.1 7.1 34.9 44.2 4.0 9.9 16.0 20.9 24.5 17.7 27.8 12.8 14.6 10.7 28.6 53.3 14.8 4.1 12.6 9.3 8.1 19.3 15.6 21.4 51.5 12.5 6.4 16.5 46.8 78.6 6.2 14.4 14.7 30.1 16.0 10.2 7.3 6.3 34.8 13.1 14.4 18.8 46.2 23.4 16.1 19.0 5.9 29.0 13.7 12.6 9.8 ULK1 "ATG1, ATG1A" ENSG00000177169 "Unc-51 like autophagy activating kinase 1" O75385 12 131894622-131923150 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" Autophagy "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Rod photoreceptor cells: 84.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "neutrophil: 4.0;plasmacytoid DC: 3.8" "Group enriched" "Detected in many" 4 "dendritic cells: 3.8;granulocytes: 4.0" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA063990 Approved Cytosol NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 59: Non-specific - Translation" "Cluster 24: NB-4 - Immune response" "Cluster 46: Photoreceptor cells - Phototransduction" Cytosol "HPA063990: AB_2685167" "unprognostic (1.53e-1)" "unprognostic (5.19e-2)" "unprognostic (2.52e-3)" "unprognostic (2.21e-3)" "unprognostic (8.01e-3)" "unprognostic (5.48e-2)" "unprognostic (2.74e-2)" "unprognostic (5.04e-3)" "unprognostic (3.94e-3)" "unprognostic (2.03e-2)" "unprognostic (9.09e-3)" "unprognostic (8.19e-2)" "unprognostic (6.25e-2)" "unprognostic (2.38e-1)" "unprognostic (2.75e-1)" "unprognostic (1.82e-2)" "unprognostic (3.16e-1)" 19.9 30.1 21.2 7.2 46.0 31.4 20.9 8.3 28.4 31.5 6.2 31.2 9.0 27.2 6.5 21.5 27.2 9.3 35.0 24.4 4.7 21.7 36.4 20.9 6.7 10.9 8.7 39.9 55.6 12.1 47.2 7.1 9.6 27.8 2.3 14.4 21.4 9.4 81.6 43.1 19.5 4.9 1.5 29.3 27.8 17.8 9.9 7.9 24.5 13.8 2.9 23.1 26.8 12.4 9.1 28.8 13.1 16.4 5.8 4.7 17.8 14.1 10.1 5.9 4.8 6.3 9.2 2.4 14.5 10.0 12.0 8.9 3.0 5.6 1.7 9.8 17.2 6.1 25.2 8.6 10.8 4.4 12.9 8.6 15.1 6.6 2.7 16.4 7.3 18.2 8.1 7.0 4.0 20.6 27.5 25.6 14.4 4.3 27.2 20.5 4.7 12.2 3.5 11.1 33.1 18.2 15.1 15.3 7.9 13.1 23.4 29.5 14.2 14.1 8.3 24.8 6.6 30.9 12.0 3.3 23.8 7.6 16.6 0.2 0.9 1.4 0.4 0.4 0.1 0.1 0.3 0.4 0.2 0.3 0.2 0.3 4.0 0.1 0.4 3.8 0.3 0.4 21.2 46.0 8.3 28.4 24.4 4.7 10.9 8.7 9.6 1.5 9.9 12.4 15.6 16.0 17.4 17.9 7.8 14.4 6.1 11.6 9.6 25.0 19.6 14.4 22.0 15.7 15.6 7.3 39.6 5.7 23.7 10.5 1.9 8.5 0.8 19.1 35.7 14.9 19.2 12.0 27.0 12.7 4.2 13.1 13.3 28.0 3.8 24.4 8.6 33.8 5.4 53.8 21.9 14.6 18.3 12.0 6.7 3.0 12.5 13.1 5.4 11.2 12.3 14.7 5.2 20.1 13.9 24.5 7.7 15.8 11.9 15.0 9.9 3.2 13.9 84.3 13.1 19.5 16.9 6.8 7.5 9.7 19.5 17.2 9.1 8.8 7.7 9.5 ULK2 "ATG1B, KIAA0623, Unc51.2" ENSG00000083290 "Unc-51 like autophagy activating kinase 2" Q8IYT8 17 19770829-19867936 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Autophagy, Neurogenesis" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 62.0;Inhibitory neurons: 76.9;Late spermatids: 70.1;Oligodendrocytes: 94.6;Spermatocytes: 58.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Group enriched" "Detected in some" 4 "intermediate monocyte: 4.0;non-classical monocyte: 3.4" "Lineage enriched" "Detected in single" 5 "monocytes: 4.0" "Cell line enhanced" "Detected in many" "SuSa: 43.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" CAB037021 Approved NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 78: Testis - Spermatogenesis" "Cluster 12: NES - Nervous system development" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "CAB037021: AB_1841237" "unprognostic (1.47e-1)" "unprognostic (1.88e-1)" "unprognostic (2.56e-1)" "unprognostic (1.03e-1)" "unprognostic (1.23e-1)" "unprognostic (1.31e-1)" "unprognostic (6.53e-2)" "unprognostic (1.07e-1)" "unprognostic (5.83e-2)" "unprognostic (1.39e-2)" "unprognostic (5.11e-3)" "unprognostic (1.39e-1)" "unprognostic (1.16e-1)" "unprognostic (3.44e-1)" "unprognostic (2.69e-1)" "unprognostic (3.23e-1)" "unprognostic (1.38e-2)" 10.5 6.9 14.3 4.6 19.8 3.0 7.8 16.9 14.9 10.0 9.7 10.8 3.0 9.3 6.4 6.3 10.8 7.4 8.3 14.9 12.1 6.5 3.4 8.4 4.8 22.1 18.8 11.4 7.5 13.3 5.3 8.1 20.7 8.0 4.2 9.4 5.9 9.8 15.2 7.5 4.7 9.5 18.3 7.1 7.5 33.8 16.6 3.9 6.4 14.7 3.7 9.0 8.5 26.5 12.7 13.1 18.0 2.4 10.2 19.3 0.0 10.3 12.8 10.6 9.8 0.2 2.6 0.0 5.4 13.4 12.0 5.8 0.0 2.1 9.9 10.6 13.2 0.3 5.2 0.0 13.1 0.0 6.3 12.5 15.6 5.4 4.4 9.3 7.6 0.0 0.0 0.0 8.1 3.4 0.0 0.5 2.7 0.2 3.3 0.8 0.0 0.0 7.3 5.3 4.6 18.7 16.4 2.0 5.2 43.7 12.6 4.5 12.0 0.0 1.5 3.7 6.3 0.0 0.0 0.0 1.6 0.0 3.8 0.0 0.9 0.2 0.2 4.0 0.1 0.0 0.5 0.5 0.8 0.0 0.8 0.5 0.2 0.2 3.4 0.0 0.1 0.3 14.3 19.8 16.9 14.9 14.9 12.1 22.1 18.8 20.7 18.3 16.6 26.5 8.9 19.2 14.1 32.3 1.8 7.4 4.7 3.2 6.8 16.1 9.5 8.1 10.9 4.3 6.1 7.3 8.4 7.7 4.4 1.4 3.9 3.1 34.2 19.6 15.3 5.3 2.4 6.7 62.0 3.4 2.8 12.0 6.6 11.3 0.0 18.0 3.6 1.7 8.5 15.2 76.9 3.9 4.1 20.5 5.1 70.1 14.0 9.1 8.8 41.2 12.3 6.1 7.2 35.2 94.6 2.5 2.4 12.4 2.1 7.5 1.0 5.4 10.0 12.7 13.1 11.5 12.7 58.2 22.1 8.6 9.7 2.9 4.7 6.6 2.9 3.8 ULK3 "DKFZP434C131, FLJ90566" ENSG00000140474 "Unc-51 like kinase 3" Q6PHR2 15 74836118-74843346 "Enzymes, Metabolic proteins, Predicted intracellular proteins" Autophagy "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Bipolar cells: 89.7;Horizontal cells: 89.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040474 Approved NA NA "Cluster 16: MAIT-cells - Unknown function" "Cluster 27: Brain & Skin - Unknown function" "Cluster 44: HDLM-2 - Immune response" "Cluster 62: Horizontal cells - Visual perception" "HPA040474: AB_2677003" "unprognostic (3.67e-2)" "unprognostic (8.90e-3)" "unprognostic (2.65e-3)" "unprognostic (1.59e-2)" "unprognostic (1.70e-1)" "unprognostic (2.07e-3)" "unprognostic (1.19e-1)" "unprognostic (1.58e-2)" "unprognostic (1.47e-2)" "unprognostic (4.18e-2)" "prognostic favorable (7.47e-4)" "unprognostic (1.97e-2)" "unprognostic (2.70e-2)" "unprognostic (1.30e-2)" "unprognostic (1.63e-1)" "unprognostic (1.16e-1)" "unprognostic (4.97e-3)" 7.1 15.2 29.5 6.4 31.5 2.2 6.1 28.1 32.2 13.6 23.0 12.1 5.0 4.4 3.5 35.7 5.5 4.5 15.9 29.4 27.3 17.6 13.8 8.3 5.8 34.0 26.6 5.7 12.0 16.2 12.5 3.5 35.8 9.9 9.4 15.4 11.5 3.1 21.0 24.7 15.7 4.4 26.1 13.1 10.6 7.1 27.8 6.3 7.6 19.0 7.8 9.4 15.4 30.4 6.7 17.7 7.4 14.4 9.3 6.7 6.0 5.1 7.3 10.1 11.1 7.0 15.4 13.0 8.8 6.2 10.8 4.7 23.1 7.6 4.4 26.1 26.1 30.3 25.0 7.4 14.8 10.3 22.5 9.4 14.0 8.2 7.1 3.5 15.8 16.8 10.3 11.9 7.0 9.4 7.3 6.6 10.0 10.6 8.7 18.6 10.3 23.0 6.0 7.4 16.7 22.3 8.6 9.8 25.6 9.1 11.0 26.8 9.4 16.0 8.9 12.7 10.3 20.7 19.7 9.3 7.4 29.5 12.4 5.2 3.5 1.4 10.9 7.3 8.7 3.3 6.4 9.0 3.7 2.8 7.1 4.8 0.8 5.8 6.1 4.0 9.2 5.1 29.5 31.5 28.1 32.2 29.4 27.3 34.0 26.6 35.8 26.1 27.8 30.4 16.5 9.6 15.3 37.2 11.4 10.1 7.5 6.0 10.2 89.7 18.1 13.6 17.1 14.3 6.7 12.9 16.7 9.2 23.3 46.4 19.6 11.0 1.0 8.9 8.8 10.7 11.4 14.1 64.7 11.7 2.5 9.2 23.4 11.9 21.0 6.2 13.2 13.3 16.1 89.2 56.5 17.5 4.1 7.9 8.2 2.2 13.1 11.2 5.4 18.7 13.2 18.4 29.9 16.6 15.3 12.3 17.9 11.7 8.6 10.4 68.5 16.5 8.0 54.5 0.0 12.9 8.8 9.5 17.3 19.7 21.7 5.7 19.7 12.3 27.9 8.9 ULK4 "FAM7C1, FLJ20574, REC01035" ENSG00000168038 "Unc-51 like kinase 4" Q96C45 3 41246599-41962130 "Disease related genes, Enzymes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "testis: 23.4" "Cell type enhanced" "Detected in many" "Early spermatids: 352.3;Excitatory neurons: 108.6;Inhibitory neurons: 99.2;Late spermatids: 405.2" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA017930 Uncertain Approved Nucleoplasm,Mitochondria,Cytosol NA NA "Cluster 35: T-regs - Unknown function" "Cluster 42: Ciliated cells - Cilium & Cell projection" "Cluster 18: U-2197 - ECM organization" "Cluster 34: Spermatids - Unknown function" "Nucleoplasm, Mitochondria, Cytosol" "HPA017930: AB_1858615" "unprognostic (3.16e-2)" "unprognostic (2.98e-3)" "unprognostic (9.72e-3)" "unprognostic (3.46e-2)" "unprognostic (2.58e-1)" "unprognostic (8.68e-2)" "unprognostic (1.87e-1)" "unprognostic (3.50e-2)" "unprognostic (1.80e-1)" "unprognostic (1.41e-1)" "unprognostic (3.75e-3)" "unprognostic (3.43e-1)" "unprognostic (1.91e-2)" "unprognostic (5.46e-2)" "unprognostic (1.61e-1)" "unprognostic (2.53e-1)" "unprognostic (6.12e-2)" 2.7 3.1 1.6 2.9 2.1 8.5 2.5 0.4 1.7 8.5 16.9 1.6 1.2 6.6 4.5 1.5 9.0 1.9 8.6 2.3 2.5 3.9 2.1 3.5 3.0 6.9 7.6 2.1 2.0 8.0 2.9 2.7 3.9 2.2 1.7 6.0 1.7 2.4 0.4 2.1 2.0 3.5 5.6 2.0 2.4 23.4 2.5 3.0 4.9 0.4 2.7 1.9 3.7 2.1 8.3 2.9 2.8 3.8 1.1 1.7 4.8 2.7 2.7 3.2 3.0 1.0 2.3 9.5 1.6 6.3 3.5 4.1 3.7 2.1 2.9 1.5 1.0 2.1 5.7 3.3 4.1 6.5 1.8 1.6 2.3 16.1 3.2 4.4 2.2 6.4 2.1 7.5 2.3 6.4 8.1 4.9 3.4 2.1 3.4 1.7 9.1 4.5 7.2 7.6 1.6 10.3 3.1 1.3 2.8 1.8 3.1 2.0 6.6 2.0 2.4 14.2 2.5 4.5 9.0 3.9 11.5 6.3 2.5 3.7 3.7 4.0 5.0 4.3 4.1 3.7 5.3 4.5 3.3 4.7 4.0 5.7 6.6 1.8 2.3 3.3 7.7 3.0 1.6 2.1 0.4 1.7 2.3 2.5 6.9 7.6 3.9 5.6 2.5 2.1 6.4 9.6 6.9 84.9 11.2 2.0 3.0 4.0 5.2 5.6 5.7 4.6 14.8 4.3 5.1 3.7 54.2 3.1 9.9 2.0 0.0 3.4 352.3 45.3 27.4 6.0 1.8 2.1 108.6 2.4 4.1 8.7 10.2 7.5 1.3 49.6 1.8 6.6 7.3 11.8 99.2 1.2 2.0 3.1 4.0 405.2 6.5 6.9 0.0 80.6 5.9 10.4 3.1 49.8 62.0 3.0 0.7 4.1 5.1 0.9 1.1 5.9 47.3 26.7 6.6 4.4 10.5 38.9 9.6 3.3 3.7 4.2 10.8 3.6 1.9 1.2 UMPS ENSG00000114491 "Uridine monophosphate synthetase" P11172 3 124730433-124749273 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" "Pyrimidine biosynthesis" "Decarboxylase, Glycosyltransferase, Lyase, Multifunctional enzyme, Transferase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in all" "Syncytiotrophoblasts: 109.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036178, HPA036179" Uncertain Approved Cytosol NA NA 9200 "Cluster 26: Non-specific - Mitochondria" "Cluster 45: Intestine - Brush border" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 18: Syncytiotrophoblasts - Pregnancy hormone signaling" Cytosol "HPA036178: AB_10673002, HPA036179: AB_10673615" "unprognostic (6.41e-2)" "unprognostic (6.70e-2)" "unprognostic (1.79e-2)" "unprognostic (1.13e-3)" "unprognostic (2.70e-1)" "unprognostic (1.72e-1)" "unprognostic (1.15e-3)" "unprognostic (5.51e-2)" "unprognostic (4.85e-3)" "unprognostic (1.43e-1)" "unprognostic (5.36e-2)" "prognostic unfavorable (9.20e-4)" "unprognostic (2.18e-2)" "unprognostic (1.58e-2)" "unprognostic (1.91e-1)" "unprognostic (4.61e-2)" "unprognostic (1.31e-1)" 1.3 1.4 2.5 1.2 2.5 1.3 1.8 2.8 2.9 1.0 1.1 2.3 2.0 1.3 1.0 2.0 1.8 0.7 0.8 2.6 1.8 1.8 2.6 0.9 1.4 2.8 2.1 1.9 2.1 1.5 0.8 0.7 2.3 1.4 1.6 1.8 1.3 0.7 3.1 2.3 2.1 1.1 2.0 2.6 1.8 0.9 2.3 1.8 1.1 0.7 1.7 0.8 1.0 3.5 1.4 4.4 5.1 2.1 2.9 3.4 5.4 7.9 2.4 3.1 2.6 3.8 2.1 4.0 8.2 3.0 7.9 9.0 7.1 2.4 5.0 4.4 4.2 8.2 3.0 2.7 2.6 8.7 6.0 3.8 2.3 1.8 3.9 1.9 1.2 8.2 3.7 1.9 2.3 3.5 10.8 1.7 12.1 3.9 2.7 7.4 6.0 3.3 2.4 2.5 4.0 2.6 11.3 4.2 4.3 3.7 4.1 3.1 15.4 2.5 5.2 7.4 3.2 8.0 12.5 12.1 2.8 3.4 2.6 5.9 10.3 5.5 14.0 11.3 12.4 17.0 9.2 12.1 14.6 24.3 13.9 10.8 0.7 12.8 9.3 11.0 12.4 11.9 2.5 2.5 2.8 2.9 2.6 1.8 2.8 2.1 2.3 2.0 2.3 3.5 9.6 6.4 11.5 6.5 11.2 15.8 24.5 41.3 18.8 8.3 8.9 12.3 6.2 20.0 22.8 9.2 4.2 66.8 13.2 9.0 29.4 29.8 3.2 10.9 18.2 15.2 9.6 16.2 11.0 30.5 35.0 12.7 14.3 12.1 12.0 22.8 7.9 31.4 22.0 5.0 12.0 10.3 20.3 7.0 5.9 4.4 13.7 8.3 3.6 10.3 18.0 11.0 13.4 15.6 12.2 23.4 8.6 13.9 10.4 14.6 14.0 25.9 22.1 9.1 13.1 13.3 17.1 23.2 32.1 20.6 19.0 109.2 11.0 29.5 17.8 21.1 UPP1 "UDRPASE, UP, UPASE, UPP" ENSG00000183696 "Uridine phosphorylase 1" Q16831 7 48088628-48108736 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "esophagus: 66.9" "Cell type enhanced" "Detected in many" "Distal enterocytes: 250.1;Extravillous trophoblasts: 260.3;Macrophages: 199.5;Paneth cells: 260.8" "Cancer enhanced" "Detected in all" "testis cancer: 62.8" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Cell line enriched" "Detected in many" 4 "hTERT-HME1: 362.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA054040, HPA055394" Enhanced Enhanced Nucleoplasm No No "Cluster 7: Monocytes - Unknown function" "Cluster 84: Esophagus - Epithelial cell function" "Cluster 30: Epithelial cell lines - Translation" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "HPA054040: AB_2682352, HPA055394: AB_2682805" "unprognostic (1.16e-1)" "prognostic unfavorable (1.02e-4)" "unprognostic (5.96e-2)" "unprognostic (1.01e-1)" "unprognostic (3.21e-3)" "unprognostic (6.36e-2)" "unprognostic (1.78e-3)" "prognostic unfavorable (1.97e-4)" "unprognostic (3.81e-2)" "unprognostic (1.91e-1)" "unprognostic (1.53e-1)" "unprognostic (2.59e-1)" "unprognostic (1.52e-3)" "unprognostic (2.95e-2)" "unprognostic (1.30e-1)" "unprognostic (1.30e-1)" "unprognostic (1.39e-1)" 16.4 9.4 3.8 7.5 4.4 12.5 10.0 3.0 5.8 16.8 2.0 9.8 4.3 3.9 0.8 66.9 5.7 5.9 8.9 3.1 3.9 39.8 11.9 18.8 3.7 4.2 2.8 1.9 4.6 5.0 7.4 3.8 3.7 4.9 5.3 0.5 14.2 1.1 3.7 3.1 6.5 3.4 1.3 20.3 4.1 2.2 4.4 1.2 8.0 0.9 6.6 9.1 31.2 3.7 19.5 26.0 2.4 5.2 8.9 4.0 29.7 7.9 15.5 14.5 17.5 10.8 9.9 0.0 2.5 9.7 89.9 13.9 5.2 46.1 9.4 4.1 4.5 0.8 4.8 4.6 7.4 0.9 1.3 5.0 21.8 6.4 362.8 5.9 9.1 0.4 1.5 13.5 7.6 2.3 0.0 2.9 9.4 4.2 20.7 0.0 4.8 6.0 33.7 11.5 2.3 1.6 10.2 3.0 63.4 29.3 2.4 0.9 12.4 29.6 22.9 7.3 22.6 21.4 34.7 3.7 29.6 3.0 77.8 11.5 16.0 12.2 11.8 12.1 8.9 0.2 7.8 8.7 6.5 0.6 8.1 8.1 6.2 5.4 14.8 0.5 8.4 10.9 3.8 4.4 3.0 5.8 3.1 3.9 4.2 2.8 3.7 1.3 4.4 3.7 107.4 19.2 58.5 5.2 19.1 46.8 26.3 104.4 19.4 27.6 9.0 16.1 11.6 24.3 51.0 11.0 33.3 15.1 122.9 250.1 70.5 50.5 1.0 42.1 22.4 108.1 13.1 4.4 16.5 40.5 260.3 34.1 5.1 91.1 25.9 3.8 72.5 17.5 110.0 16.8 29.4 35.0 85.5 130.5 118.1 2.4 5.3 199.5 87.2 1.0 61.4 13.3 71.1 4.0 3.6 117.9 260.8 2.2 30.3 30.4 42.8 23.3 11.9 29.2 6.6 21.1 32.2 0.3 9.5 42.9 29.8 78.7 71.0 1.5 29.1 34.9 UPP2 "UDRPASE2, UP2, UPASE2" ENSG00000007001 "Uridine phosphorylase 2" O95045 2 157876702-158136154 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Group enriched" "Detected in some" 9 "kidney: 45.8;liver: 23.9" "Cell type enhanced" "Detected in some" "Astrocytes: 24.2;Distal tubular cells: 13.7;Excitatory neurons: 32.5;Inhibitory neurons: 20.8;Oligodendrocyte precursor cells: 27.6;Proximal tubular cells: 82.1" "Cancer enriched" "Detected in some" 6 "liver cancer: 3.6" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "HPA035225, HPA035226" Approved Nucleoplasm,Vesicles,Mitochondria NA NA "Cluster 81: Kidney & Liver - Metabolism" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm "Vesicles, Mitochondria" "HPA035225: AB_10604002, HPA035226: AB_10696503" "unprognostic (1.87e-1)" "unprognostic (2.33e-1)" "unprognostic (4.22e-3)" "unprognostic (1.36e-3)" "unprognostic (2.29e-1)" "unprognostic (1.55e-1)" "unprognostic (3.53e-2)" "unprognostic (5.51e-2)" "unprognostic (5.11e-2)" "unprognostic (1.23e-2)" "unprognostic (4.65e-3)" "unprognostic (2.34e-1)" "unprognostic (2.23e-2)" "unprognostic (4.89e-2)" "unprognostic (2.78e-2)" "unprognostic (1.78e-2)" "unprognostic (1.16e-2)" 0.0 0.1 3.3 0.0 2.9 0.0 0.0 1.8 3.0 0.1 1.4 0.0 0.0 0.0 0.3 0.0 0.1 0.1 0.0 3.7 1.9 45.8 23.9 0.0 0.1 1.3 1.3 0.3 0.1 0.0 0.2 0.0 1.1 0.0 0.0 0.9 0.4 0.0 0.0 0.3 0.1 0.0 1.4 0.0 0.0 0.1 1.6 0.0 0.2 0.0 0.0 0.0 0.0 2.4 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.2 0.1 0.2 0.2 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.3 2.9 1.8 3.0 3.7 1.9 1.3 1.3 1.1 1.4 1.6 2.4 0.0 0.0 0.0 24.2 0.2 0.0 0.1 0.0 0.0 1.3 0.1 0.3 0.1 0.0 0.0 1.8 0.0 0.0 0.0 0.0 13.7 0.0 0.1 0.2 0.1 0.1 0.0 0.0 32.5 0.0 0.0 0.0 0.0 0.1 0.0 0.1 1.1 8.2 0.0 0.0 20.8 0.0 0.0 0.9 0.0 0.1 0.3 0.5 0.0 2.8 0.0 0.1 0.0 27.6 3.3 0.0 0.0 0.0 0.0 0.0 0.0 82.1 0.0 1.4 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.1 VRK1 ENSG00000100749 "VRK serine/threonine kinase 1" Q99986 14 96797304-96954846 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Serine/threonine-protein kinase, Transferase" Neurodegeneration "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 50.4;testis: 37.1" "Cell type enhanced" "Detected in all" "Spermatocytes: 198.9;Spermatogonia: 110.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA000660, HPA017929" Enhanced Supported Nucleoplasm,Cytosol Yes No "Cluster 15: NK-cells - Transcription" "Cluster 75: Bone marrow - mRNA splicing & Cell cycle" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 12: Non-specific - Cell cycle regulation" Nucleoplasm Cytosol "HPA000660: AB_1080579, HPA017929: AB_1858770" "unprognostic (1.03e-1)" "unprognostic (1.17e-2)" "unprognostic (1.84e-2)" "unprognostic (2.24e-3)" "unprognostic (5.42e-2)" "unprognostic (1.19e-2)" "prognostic unfavorable (4.15e-4)" "unprognostic (4.20e-2)" "unprognostic (2.11e-2)" "unprognostic (5.47e-2)" "unprognostic (5.14e-2)" "unprognostic (1.60e-1)" "unprognostic (2.53e-2)" "unprognostic (6.70e-2)" "unprognostic (4.56e-2)" "unprognostic (3.36e-2)" "unprognostic (1.58e-1)" 5.9 5.2 5.9 12.8 7.1 50.4 11.5 6.0 7.9 5.2 4.3 10.8 6.5 6.5 6.9 8.9 9.2 4.4 5.2 5.9 5.1 4.9 5.5 4.9 27.1 5.3 5.5 6.0 3.2 5.4 3.1 7.6 5.4 5.0 12.3 4.4 4.3 5.0 4.7 7.4 7.2 6.7 4.8 11.3 6.5 37.1 5.9 35.5 5.9 4.6 27.9 7.7 5.4 7.0 52.4 27.0 78.5 30.2 9.2 14.9 44.8 42.8 34.4 67.1 65.4 36.0 54.7 139.2 22.4 24.3 39.2 56.5 75.5 54.4 90.5 73.4 36.4 90.5 18.7 39.3 10.2 168.5 49.2 8.5 9.7 50.4 32.6 12.8 47.0 104.8 76.6 79.0 56.9 65.5 137.1 76.5 47.8 39.9 59.3 124.5 134.2 48.6 32.3 59.3 53.2 28.0 34.2 36.4 30.8 36.0 39.3 66.6 24.4 27.9 22.8 47.7 37.3 37.7 53.5 124.8 44.7 74.6 34.8 42.7 12.3 26.2 21.5 15.5 29.0 31.3 24.9 26.4 15.7 32.7 27.1 27.3 6.5 45.6 15.2 21.4 34.9 19.4 5.9 7.1 6.0 7.9 5.9 5.1 5.3 5.5 5.4 4.8 5.9 7.0 15.3 3.2 4.6 6.8 30.6 16.8 13.8 23.3 6.2 12.4 9.3 11.3 11.8 12.8 16.7 14.7 8.4 34.8 24.8 6.3 11.7 13.5 21.3 21.1 8.3 12.4 3.0 76.2 42.0 19.4 48.3 11.4 14.8 10.8 28.5 20.0 7.1 3.3 19.2 10.1 36.2 10.4 20.3 11.8 14.9 11.5 5.6 12.0 12.4 19.7 14.2 6.2 27.8 12.1 19.8 10.3 2.2 9.8 25.4 6.1 3.0 11.2 37.6 9.6 19.7 14.3 15.1 198.9 110.9 14.1 13.9 15.1 26.8 9.2 18.1 10.4 VRK2 ENSG00000028116 "VRK serine/threonine kinase 2" Q86Y07 2 57907629-58159920 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Host-virus interaction" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enriched" "Detected in many" 9 "Oligodendrocytes: 540.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB046459, HPA047503" Approved Supported "Endoplasmic reticulum" NA NA "Cluster 19: B-cells - Humoral immune response" "Cluster 70: Brain - Nervous system development" "Cluster 44: HDLM-2 - Immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Endoplasmic reticulum" "CAB046459: AB_1858773, HPA047503: AB_2680071" "unprognostic (1.87e-1)" "unprognostic (5.84e-2)" "unprognostic (4.65e-2)" "unprognostic (1.33e-3)" "unprognostic (1.27e-1)" "unprognostic (1.60e-2)" "prognostic unfavorable (6.32e-6)" "unprognostic (3.90e-2)" "unprognostic (4.76e-2)" "unprognostic (2.96e-2)" "prognostic unfavorable (4.65e-4)" "unprognostic (1.36e-1)" "prognostic unfavorable (4.66e-5)" "unprognostic (3.48e-1)" "unprognostic (1.62e-1)" "unprognostic (2.99e-1)" "unprognostic (3.56e-1)" 14.8 13.2 14.9 20.2 26.4 18.8 17.2 15.1 16.2 10.8 9.3 14.0 10.9 15.3 16.7 19.5 13.4 11.9 15.6 12.8 16.0 10.7 16.8 15.9 22.5 23.9 21.1 10.7 19.7 14.7 7.6 14.6 23.0 14.2 16.4 4.8 13.8 11.4 14.3 13.3 11.0 19.4 14.8 18.0 13.7 13.3 18.9 12.7 18.6 15.1 26.0 14.7 12.6 40.6 37.1 24.3 2.7 16.3 16.7 30.6 48.4 32.8 33.3 22.7 22.9 49.8 38.5 44.3 43.0 29.8 37.1 27.4 34.9 36.7 33.7 80.9 23.1 50.9 19.0 35.8 27.8 44.1 29.0 17.7 42.6 36.3 52.8 26.1 64.9 6.2 50.2 28.5 38.2 21.2 0.3 32.9 29.9 56.9 11.6 49.4 12.0 30.6 36.8 30.2 9.4 0.3 52.5 31.2 27.5 26.2 22.0 26.1 37.0 0.5 74.4 20.6 0.6 40.5 33.9 24.0 18.2 52.7 38.4 31.0 24.5 35.3 15.1 32.2 18.4 30.6 14.2 17.7 25.5 31.7 10.6 13.6 9.0 18.7 34.3 26.4 18.5 15.4 14.9 26.4 15.1 16.2 12.8 16.0 23.9 21.1 23.0 14.8 18.9 40.6 17.9 22.4 11.2 1.3 26.4 9.8 12.6 21.8 14.8 1.0 14.0 10.2 21.8 7.2 22.4 18.4 0.0 21.2 13.7 6.5 15.6 27.1 23.0 12.7 10.9 15.8 6.6 39.1 2.7 26.2 21.1 14.0 16.3 12.7 17.7 9.6 8.9 8.4 18.4 0.0 4.7 5.1 30.5 19.1 19.1 8.4 5.9 26.2 10.6 54.4 41.7 5.3 16.5 32.2 540.8 24.8 8.7 6.0 25.7 18.4 2.5 9.5 30.7 4.0 6.6 7.4 14.3 22.0 10.9 19.2 8.4 19.4 16.5 6.8 7.9 16.4 WEE1 WEE1A ENSG00000166483 "WEE1 G2 checkpoint kinase" P30291 11 9573670-9593457 "Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Cell cycle, Cell division, Mitosis" "Kinase, Transferase, Tyrosine-protein kinase" "Cancer-related genes" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Basal squamous epithelial cells: 213.9;Glandular and luminal cells: 262.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in many" "CAB004619, HPA068845" Approved Approved Nucleoli No No "Cluster 43: B-cells - Humoral immune response" "Cluster 46: Fibroblasts - ECM organization" "Cluster 28: BEWO - Transcription regulation" "Cluster 44: Endometrium - Transcription" Nucleoli "CAB004619: AB_628447, HPA068845: AB_2686048" "unprognostic (6.04e-2)" "unprognostic (1.90e-3)" "unprognostic (1.09e-2)" "unprognostic (9.29e-2)" "unprognostic (1.26e-1)" "unprognostic (1.39e-2)" "unprognostic (3.79e-3)" "unprognostic (2.48e-2)" "unprognostic (1.22e-1)" "unprognostic (1.79e-2)" "unprognostic (3.21e-3)" "unprognostic (3.73e-1)" "prognostic unfavorable (5.19e-4)" "unprognostic (1.07e-1)" "unprognostic (3.06e-1)" "unprognostic (2.08e-1)" "unprognostic (3.80e-1)" 12.7 5.6 1.5 14.1 1.3 23.0 46.1 2.4 2.3 21.5 2.8 18.4 10.6 62.6 24.5 46.3 18.6 49.0 43.0 1.2 2.3 16.8 57.8 11.6 24.8 2.8 4.0 10.9 10.1 17.8 8.4 34.6 3.6 21.2 14.4 4.5 17.4 12.7 10.4 57.1 13.5 35.0 2.2 8.1 17.2 31.5 2.0 23.7 26.6 7.2 30.2 53.0 15.4 1.9 43.1 16.4 69.1 38.8 65.2 29.8 125.9 48.8 44.8 29.3 29.8 33.8 53.3 100.7 18.0 27.6 30.8 48.8 49.0 23.3 41.1 33.3 30.7 43.1 30.1 26.2 7.0 66.6 39.7 12.0 25.3 13.8 53.8 34.9 21.6 43.6 64.0 75.8 55.7 13.2 63.5 39.4 97.6 36.9 18.5 57.6 54.5 24.6 28.1 100.0 25.0 31.8 39.9 48.6 29.2 89.3 27.1 32.9 21.7 51.1 35.2 23.0 42.2 14.4 51.1 140.1 23.3 36.5 41.0 0.0 0.0 6.0 1.7 0.0 0.2 8.0 1.7 3.0 0.1 4.7 0.1 1.3 0.1 1.9 0.0 0.1 7.1 0.6 1.5 1.3 2.4 2.3 1.2 2.3 2.8 4.0 3.6 2.2 2.0 1.9 17.2 51.3 33.9 0.0 36.8 176.4 170.4 38.5 213.9 1.8 168.5 67.2 61.1 65.8 53.5 42.3 0.0 94.8 11.2 54.7 13.7 24.9 25.0 160.1 86.2 18.7 61.1 40.4 0.1 13.6 200.1 39.2 52.5 262.4 7.0 28.5 9.7 85.0 17.0 1.7 0.4 65.6 18.3 2.5 21.9 41.7 11.8 10.0 17.8 1.0 2.4 9.9 8.2 2.0 0.1 24.8 38.5 10.9 17.2 82.7 35.9 8.3 62.6 7.1 6.6 180.7 23.7 61.4 44.4 181.4 191.1 137.2 19.0 11.8 55.5 85.5 WEE2 "FLJ16107, WEE1B" ENSG00000214102 "WEE2 oocyte meiosis inhibiting kinase" P0C1S8 7 141708353-141731271 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins" Meiosis "Kinase, Transferase, Tyrosine-protein kinase" "Disease variant" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "Distal tubular cells: 1.9;Proximal tubular cells: 2.3" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enriched" "Detected in single" 5 "CACO-2: 3.1" "Not detected" "Not detected" "Low region specificity" "Detected in many" "HPA027418, HPA054280" Uncertain Enhanced Nucleoplasm,Cytosol NA NA "Cluster 39: CACO-2 - Unknown function" "Cluster 67: Proximal tubular cells - Tubular reabsorption" Nucleoplasm Cytosol "HPA027418: AB_10603144, HPA054280: " "unprognostic (6.35e-2)" "unprognostic (1.47e-1)" "unprognostic (1.89e-1)" "unprognostic (3.18e-1)" "unprognostic (2.33e-1)" "unprognostic (4.00e-2)" "unprognostic (2.90e-1)" "unprognostic (1.97e-2)" "unprognostic (3.23e-2)" "unprognostic (3.02e-2)" "unprognostic (2.61e-1)" "unprognostic (1.76e-2)" "unprognostic (1.73e-1)" "unprognostic (3.25e-2)" "unprognostic (2.66e-1)" "unprognostic (6.07e-2)" "unprognostic (2.88e-3)" 0.2 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.2 0.0 0.3 0.2 0.4 0.3 0.0 0.0 0.3 0.0 0.1 0.4 0.1 0.1 0.3 0.3 0.0 0.1 0.0 0.1 0.1 0.0 0.2 0.2 0.0 0.2 0.6 0.1 0.0 0.2 0.1 0.2 0.3 0.1 0.0 0.4 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.5 0.3 0.0 0.0 0.2 0.0 0.0 0.0 0.0 3.1 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.5 0.0 0.0 0.0 0.1 0.4 0.1 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.6 0.4 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.6 0.4 0.2 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.1 0.1 0.1 0.2 0.1 0.1 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.1 0.1 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.9 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.5 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 2.3 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 WNK1 "HSAN2, HSN2, PPP1R167, PRKWNK1" ENSG00000060237 "WNK lysine deficient protein kinase 1" Q9H4A3 12 752579-911452 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Protein kinase inhibitor, Serine/threonine-protein kinase, Transferase" "Neurodegeneration, Neuropathy" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "brain: 293.0" "Cell type enhanced" "Detected in all" "Oligodendrocytes: 336.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA046541, HPA059157" Enhanced Supported Cytosol NA NA 92000 "Cluster 8: Neutrophils - Inflammatory response" "Cluster 70: Brain - Nervous system development" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 10: Non-specific - Unknown function" Cytosol "HPA046541: AB_2679690, HPA059157: AB_2683935" "unprognostic (1.40e-1)" "unprognostic (1.54e-2)" "unprognostic (4.82e-2)" "unprognostic (1.75e-1)" "unprognostic (1.27e-1)" "unprognostic (7.68e-2)" "unprognostic (1.05e-3)" "unprognostic (1.57e-1)" "unprognostic (1.24e-1)" "prognostic unfavorable (9.67e-4)" "unprognostic (1.84e-1)" "unprognostic (2.49e-1)" "unprognostic (4.38e-1)" "unprognostic (1.40e-1)" "unprognostic (1.32e-1)" "unprognostic (5.17e-2)" "unprognostic (1.30e-2)" 56.7 20.6 190.8 36.4 236.8 54.2 33.5 179.4 166.1 32.8 110.8 22.8 14.4 26.7 30.4 72.1 29.4 27.1 63.8 132.3 161.1 84.0 31.6 44.6 39.2 232.3 238.4 30.1 22.5 51.1 17.0 36.0 217.0 29.7 24.2 87.4 24.0 33.4 79.7 52.0 17.4 36.1 225.4 30.2 27.6 48.3 238.0 61.3 27.7 79.8 46.9 35.8 43.8 293.0 53.9 97.5 131.8 11.3 88.1 80.0 52.2 48.3 61.6 58.2 51.3 59.4 55.7 71.0 16.8 107.8 73.5 39.8 93.8 56.7 84.3 124.7 51.4 169.4 122.2 46.1 66.7 86.9 68.2 64.0 82.1 97.6 164.4 61.6 73.4 68.0 76.4 158.2 77.8 54.1 154.6 15.6 105.8 47.8 24.3 78.0 138.8 20.8 80.6 96.8 35.1 40.7 121.8 82.9 33.6 183.3 86.8 97.2 78.3 67.1 77.3 86.2 70.8 23.8 43.1 103.8 59.4 44.6 53.2 0.7 1.8 1.6 1.9 2.1 1.9 1.7 1.9 2.1 1.4 1.2 1.2 1.9 5.6 1.4 4.7 1.2 3.4 1.6 190.8 236.8 179.4 166.1 132.3 161.1 232.3 238.4 217.0 225.4 238.0 293.0 261.1 102.5 141.6 77.1 65.3 112.8 42.3 38.3 85.4 87.9 50.6 39.5 241.6 50.1 47.1 90.1 150.1 32.5 83.0 27.8 86.1 28.0 29.7 63.0 68.6 106.7 58.7 304.2 182.3 24.4 32.9 58.3 37.2 70.2 52.6 46.2 52.5 71.7 57.3 84.1 165.0 26.3 16.2 121.4 80.8 21.2 61.8 96.7 37.4 114.3 95.7 64.0 61.8 126.7 336.4 41.7 34.8 55.7 76.5 59.0 24.2 21.8 64.6 96.1 13.1 69.6 63.8 186.5 74.6 147.2 136.0 28.5 112.9 33.2 25.8 55.2 WNK2 "KIAA1760, NY-CO-43, PRKWNK2, SDCCAG43" ENSG00000165238 "WNK lysine deficient protein kinase 2" Q9Y3S1 9 93184916-93320572 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "heart muscle: 83.1;skeletal muscle: 62.3" "Cell type enhanced" "Detected in many" "Astrocytes: 76.4;Cone photoreceptor cells: 160.6;Excitatory neurons: 128.5;Inhibitory neurons: 98.8;Intestinal goblet cells: 77.3;Rod photoreceptor cells: 106.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "Daudi: 18.8;Hep G2: 31.0;SCLC-21H: 37.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA015555, HPA016519, CAB017813" Enhanced Approved Cytosol NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 38: Heart - Muscle contraction" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 53: Intestinal epithelial cells - Unknown function" Cytosol "CAB017813: , HPA015555: AB_2669218, HPA016519: AB_2669380" "unprognostic (5.02e-2)" "unprognostic (1.32e-2)" "unprognostic (2.61e-1)" "unprognostic (1.95e-1)" "unprognostic (2.28e-1)" "unprognostic (1.01e-1)" "unprognostic (2.04e-1)" "unprognostic (1.79e-3)" "unprognostic (1.94e-1)" "unprognostic (2.81e-2)" "unprognostic (1.31e-3)" "unprognostic (2.23e-1)" "unprognostic (4.48e-3)" "unprognostic (6.51e-2)" "unprognostic (1.44e-1)" "unprognostic (4.38e-4)" "unprognostic (1.62e-1)" 2.0 3.0 14.9 3.3 14.8 0.0 4.9 4.6 39.1 4.7 0.3 36.0 17.9 5.8 4.2 5.7 15.4 1.3 83.1 18.3 7.7 0.8 1.3 0.9 0.5 13.8 6.0 1.1 42.8 2.3 29.6 3.0 8.8 16.7 11.9 28.8 47.3 12.3 62.3 15.8 21.5 4.5 1.9 2.7 14.7 6.6 14.2 7.1 1.8 31.0 1.0 5.5 3.4 10.5 7.4 6.6 4.6 13.2 0.0 0.0 8.8 0.0 0.0 0.1 0.0 2.7 0.2 18.8 2.4 0.0 1.3 0.3 10.4 0.0 0.0 0.0 12.1 0.0 5.8 31.0 0.0 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.0 2.3 12.2 0.0 0.0 9.8 0.2 0.2 11.5 7.2 0.4 0.0 0.0 15.3 0.0 1.1 37.6 14.8 2.4 10.2 0.9 1.3 1.3 2.2 0.1 0.0 4.8 0.2 0.0 0.0 0.0 9.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 14.9 14.8 4.6 39.1 18.3 7.7 13.8 6.0 8.8 1.9 14.2 10.5 0.3 0.0 0.0 76.4 0.3 1.3 8.5 3.1 0.0 62.0 19.4 18.7 58.1 31.5 14.1 0.0 160.6 15.5 0.2 34.3 0.0 17.1 1.2 7.7 9.2 1.3 32.4 0.0 128.5 9.1 6.7 2.7 3.6 15.8 0.0 8.6 0.4 0.2 3.4 1.7 98.8 77.3 6.1 1.3 2.2 2.6 0.9 0.1 1.8 29.0 0.6 60.3 0.0 9.0 3.2 3.2 57.0 6.0 0.2 11.1 47.7 1.1 6.6 106.8 13.1 3.5 5.0 0.7 7.7 1.1 5.5 15.6 0.4 0.1 59.0 8.9 WNK3 PRKWNK3 ENSG00000196632 "WNK lysine deficient protein kinase 3" Q9BYP7 X 54192823-54358642 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in some" "epididymis: 11.7;testis: 9.9" "Group enriched" "Detected in many" 4 "Cardiomyocytes: 193.3;Granulosa cells: 199.5" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "AF22: 4.5;AN3-CA: 3.4;HAP1: 5.2;NTERA-2: 9.1;SiHa: 4.5;SuSa: 3.8;U-2 OS: 3.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA077678 Approved Approved Vesicles NA NA "Cluster 32: T-cells - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 12: NES - Nervous system development" "Cluster 40: Granulosa cells - Unknown function" Vesicles "HPA077678: AB_2686850" "unprognostic (1.86e-1)" "unprognostic (1.68e-3)" "unprognostic (2.44e-1)" "unprognostic (7.87e-5)" "unprognostic (4.82e-3)" "unprognostic (1.85e-3)" "unprognostic (1.85e-2)" "unprognostic (3.32e-2)" "unprognostic (3.38e-1)" "unprognostic (3.03e-2)" "unprognostic (5.78e-4)" "unprognostic (2.22e-1)" "unprognostic (2.64e-2)" "unprognostic (5.61e-2)" "unprognostic (9.99e-2)" "unprognostic (7.63e-2)" "unprognostic (8.74e-2)" 0.2 2.5 1.6 0.1 1.7 0.1 0.6 0.3 1.9 0.6 0.0 0.3 0.2 0.5 11.7 0.2 0.8 0.3 0.7 1.0 4.6 1.0 3.6 0.3 0.1 1.6 4.8 3.0 0.3 0.9 2.4 0.3 2.4 0.9 0.0 3.3 0.3 0.8 0.1 0.3 0.2 0.5 0.6 0.2 0.6 9.9 4.5 0.1 0.6 0.1 0.1 0.5 0.4 1.2 0.0 0.0 4.5 3.4 0.0 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.1 0.0 1.8 0.0 5.2 0.1 0.2 0.0 0.9 0.0 0.0 0.1 0.1 0.0 0.1 0.3 0.0 0.1 0.0 0.8 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 9.1 0.0 0.0 2.2 0.6 0.0 0.9 0.1 1.4 1.3 4.5 0.0 0.5 3.8 0.4 0.0 0.2 0.0 3.9 0.0 1.0 0.0 3.3 0.0 1.2 0.0 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 1.7 0.3 1.9 1.0 4.6 1.6 4.8 2.4 0.6 4.5 1.2 1.9 0.0 2.3 18.3 0.7 3.7 4.3 0.3 9.1 24.9 5.8 6.9 193.3 2.8 3.2 7.3 14.6 0.2 0.0 0.1 5.9 1.7 6.4 2.0 7.8 8.5 0.0 0.8 14.5 0.0 0.3 6.7 0.0 4.9 6.3 199.5 20.3 48.3 0.1 35.3 29.7 0.0 2.0 0.8 1.5 20.4 15.8 0.6 0.0 3.7 0.0 19.5 0.0 48.2 19.2 0.2 0.0 43.6 0.0 6.0 0.0 3.9 0.2 43.3 6.6 4.8 10.5 43.8 46.3 2.1 1.1 0.1 1.5 9.8 0.0 1.4 WNK4 PRKWNK4 ENSG00000126562 "WNK lysine deficient protein kinase 4" Q96J92 17 42780610-42797066 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins" "Kinase, Serine/threonine-protein kinase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "intestine: 11.0;kidney: 37.6;prostate: 11.6" "Cell type enriched" "Detected in some" 4 "Distal tubular cells: 160.4" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "fHDF/TERT166: 32.6;K-562: 36.8;TIME: 34.1;WM-115: 23.0" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" HPA016500 Approved NA NA "Cluster 7: Kidney - Transmembrane transport" "Cluster 10: BJ & FHDF - ECM organization" "Cluster 39: Non-specific - Basic cellular processes" "HPA016500: AB_10962984" "unprognostic (6.34e-3)" "unprognostic (1.35e-1)" "unprognostic (2.15e-1)" "unprognostic (5.58e-2)" "unprognostic (1.78e-2)" "unprognostic (1.96e-1)" "unprognostic (2.48e-1)" "unprognostic (1.69e-1)" "unprognostic (5.84e-2)" "unprognostic (3.94e-1)" "unprognostic (2.08e-3)" "unprognostic (4.33e-3)" "unprognostic (7.70e-3)" "unprognostic (1.62e-1)" "unprognostic (6.11e-2)" "unprognostic (1.43e-1)" "unprognostic (7.99e-2)" 1.3 0.0 0.7 1.1 0.9 0.0 2.8 0.8 3.3 0.6 0.3 9.8 1.9 0.2 0.7 8.9 0.4 0.0 0.1 1.7 1.1 37.6 0.2 0.1 0.1 1.1 0.7 4.3 0.2 0.0 1.2 0.0 0.7 11.6 11.0 0.6 1.8 1.1 0.0 0.5 3.7 0.4 0.6 0.1 3.4 0.2 1.0 0.0 0.0 0.3 0.1 0.2 0.4 1.0 2.1 1.2 0.6 0.0 0.7 0.2 4.8 11.9 4.8 4.5 1.3 0.7 1.0 0.6 6.8 32.6 1.2 0.0 0.2 0.3 8.6 0.6 1.8 0.1 0.0 4.7 7.4 0.3 0.7 3.9 1.4 6.4 2.1 2.1 0.3 0.4 36.8 1.3 0.0 1.0 0.0 1.1 0.3 2.0 8.2 0.6 1.2 0.0 0.0 0.5 0.0 0.2 0.1 0.2 1.7 4.1 2.4 2.7 34.1 0.3 3.1 0.5 0.4 6.2 5.3 1.2 0.0 2.1 23.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.7 0.9 0.8 3.3 1.7 1.1 1.1 0.7 0.7 0.6 1.0 1.0 0.2 0.0 0.6 0.0 0.5 0.0 0.2 0.0 0.6 0.2 7.1 4.1 1.0 1.5 0.6 7.3 0.0 0.0 0.3 8.0 160.4 0.0 0.0 5.1 1.1 0.2 13.1 0.0 0.2 0.2 0.2 0.1 3.1 6.7 4.5 0.1 0.7 0.0 0.0 0.0 0.2 40.1 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 3.2 0.4 0.0 3.6 0.9 1.0 2.9 0.5 0.0 0.2 0.5 0.8 0.8 12.1 0.4 0.0 0.2 0.0 13.1 0.3 WWP1 "AIP5, DKFZP434D2111" ENSG00000123124 "WW domain containing E3 ubiquitin protein ligase 1" Q9H0M0 8 86342547-86478420 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Host-virus interaction, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "skeletal muscle: 171.4" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA023180 Approved Approved "Golgi apparatus,Plasma membrane,Cytosol" NA NA "Cluster 32: T-cells - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 8: SK-BR-3 - Unknown function" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" Cytosol "Golgi apparatus, Plasma membrane" "HPA023180: AB_10602587" "unprognostic (3.89e-1)" "unprognostic (6.63e-2)" "unprognostic (3.81e-2)" "unprognostic (7.91e-2)" "unprognostic (3.70e-1)" "unprognostic (1.02e-1)" "unprognostic (1.93e-1)" "unprognostic (4.24e-2)" "unprognostic (1.83e-1)" "unprognostic (9.43e-3)" "unprognostic (3.09e-3)" "unprognostic (1.48e-1)" "prognostic favorable (5.45e-5)" "unprognostic (2.35e-1)" "unprognostic (4.63e-1)" "unprognostic (3.19e-3)" "unprognostic (1.01e-1)" 33.6 22.1 16.3 25.8 21.5 18.2 40.6 19.6 16.3 23.6 24.3 26.9 26.3 23.0 24.6 33.1 18.5 45.3 50.8 14.3 20.7 40.9 111.7 27.2 39.0 18.3 19.0 24.7 28.0 116.3 9.8 36.9 19.7 33.4 33.1 43.2 25.9 25.6 171.4 40.8 28.1 24.6 18.1 45.7 34.3 29.5 19.5 22.7 32.6 122.2 30.6 33.7 15.8 23.1 59.8 27.1 18.3 13.1 23.0 22.4 16.3 21.0 22.5 16.5 19.5 18.9 35.3 24.9 14.0 36.5 22.9 49.3 26.4 34.1 28.5 31.6 21.0 28.7 24.4 44.7 16.8 11.7 14.0 20.5 42.5 18.2 33.3 25.3 74.1 29.0 14.3 28.7 28.4 29.6 27.7 8.1 11.2 82.6 30.0 18.0 21.4 22.5 37.3 44.5 5.5 12.9 21.2 104.7 23.0 39.8 31.3 10.8 84.4 23.9 28.7 26.3 10.7 33.9 22.0 25.7 29.9 1.6 19.0 6.2 2.1 3.9 5.2 1.9 4.6 2.7 6.4 5.3 1.5 2.4 7.5 4.7 1.3 2.4 2.2 1.9 6.5 2.0 16.3 21.5 19.6 16.3 14.3 20.7 18.3 19.0 19.7 18.1 19.5 23.1 51.2 25.6 22.6 29.0 13.0 35.8 26.9 15.4 26.7 28.8 41.7 23.5 82.7 44.3 19.2 29.5 58.4 28.3 19.5 23.7 43.0 20.5 42.1 22.6 20.1 32.3 23.6 3.0 55.3 37.6 3.3 27.6 35.2 35.5 3.8 18.0 62.4 88.8 55.9 40.4 134.6 25.3 14.2 95.2 28.1 12.7 32.3 43.0 30.2 61.8 18.6 23.3 18.6 60.3 103.8 45.1 16.0 36.5 18.5 45.1 15.8 45.7 17.2 52.6 6.6 18.8 16.6 12.4 21.2 28.8 39.5 23.0 32.0 25.1 19.7 38.3 WWP2 AIP2 ENSG00000198373 "WW domain containing E3 ubiquitin protein ligase 2" O00308 16 69762328-69941741 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Host-virus interaction, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Oligodendrocyte precursor cells: 79.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA "Cluster 8: Neutrophils - Inflammatory response" "Cluster 18: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 68: Oligodendrocytes - Mixed function" "unprognostic (1.63e-1)" "unprognostic (3.72e-2)" "unprognostic (1.93e-1)" "unprognostic (1.09e-3)" "unprognostic (2.86e-1)" "unprognostic (1.73e-1)" "unprognostic (1.14e-2)" "unprognostic (5.22e-2)" "unprognostic (1.14e-1)" "unprognostic (7.50e-2)" "unprognostic (2.08e-2)" "unprognostic (9.81e-2)" "prognostic favorable (5.87e-11)" "unprognostic (4.26e-2)" "unprognostic (4.10e-2)" "unprognostic (1.08e-1)" "unprognostic (1.62e-1)" 27.3 31.2 22.4 18.2 23.5 34.1 22.8 19.7 22.3 23.5 23.8 23.2 23.4 22.6 10.1 26.2 23.5 15.1 16.7 20.0 20.9 31.7 18.4 23.4 22.0 22.9 21.5 23.4 29.6 25.9 17.7 16.2 22.2 20.5 19.8 15.5 31.9 17.2 21.6 30.7 23.5 14.3 19.7 30.2 26.3 16.1 22.0 19.7 22.6 9.3 19.3 18.8 20.9 26.6 25.0 24.8 15.7 16.3 12.9 10.7 24.1 16.3 18.6 27.4 28.3 23.1 18.5 28.4 17.4 29.2 14.9 28.6 20.8 24.7 20.4 13.4 17.9 15.9 15.1 39.4 24.1 28.3 22.4 15.7 17.9 37.4 25.9 15.4 25.6 24.1 24.5 15.5 17.6 43.2 15.5 30.9 22.1 20.6 10.5 34.6 13.1 49.5 26.6 23.6 19.3 21.3 69.1 19.8 15.4 10.2 30.9 34.6 25.6 21.3 30.8 29.9 19.8 36.3 26.0 42.7 22.9 23.6 38.2 35.9 19.0 29.8 16.3 23.5 12.2 10.8 12.1 13.0 14.9 12.4 12.3 8.7 49.7 8.5 30.8 7.0 11.7 17.1 22.4 23.5 19.7 22.3 20.0 20.9 22.9 21.5 22.2 19.7 22.0 26.6 11.9 9.6 31.0 16.0 18.7 7.4 7.0 5.4 9.1 9.0 10.0 8.3 8.7 21.5 12.8 14.7 10.4 10.0 13.1 47.2 1.9 12.3 22.6 13.9 7.5 13.1 16.8 13.9 20.3 20.0 9.2 8.2 31.1 14.4 21.5 12.7 13.2 13.3 12.8 10.1 26.0 16.1 6.1 22.7 13.6 38.5 10.2 18.8 10.6 42.2 18.8 12.3 19.6 79.4 56.4 16.8 23.6 8.6 12.4 6.1 22.6 10.0 24.1 6.5 13.1 6.9 17.7 8.1 6.0 9.6 6.0 20.0 14.6 7.0 20.4 9.9 XIAP "API3, BIRC4, hILP, ILP-1" ENSG00000101966 "X-linked inhibitor of apoptosis" P98170 X 123859724-123913976 "Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway, Wnt signaling pathway" "Protease inhibitor, Thiol protease inhibitor, Transferase" "Cancer-related genes, FDA approved drug targets" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB009203, HPA042428" Approved Supported "Nucleoplasm,Plasma membrane,Cytosol" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 18: U-2197 - ECM organization" "Cluster 53: Intestinal epithelial cells - Unknown function" "Nucleoplasm, Cytosol" "Plasma membrane" "CAB009203: AB_2257167, HPA042428: AB_2677993" "prognostic unfavorable (9.21e-4)" "unprognostic (8.43e-2)" "unprognostic (1.50e-2)" "unprognostic (2.14e-1)" "unprognostic (1.40e-1)" "unprognostic (9.41e-2)" "unprognostic (1.95e-2)" "unprognostic (8.51e-2)" "unprognostic (9.17e-2)" "unprognostic (3.90e-2)" "unprognostic (7.50e-2)" "unprognostic (4.41e-2)" "unprognostic (3.15e-3)" "unprognostic (8.21e-3)" "unprognostic (2.26e-1)" "unprognostic (4.99e-2)" "unprognostic (4.65e-2)" 9.2 7.7 6.5 9.2 7.5 8.3 9.7 6.8 7.0 9.6 12.9 12.4 10.1 8.4 10.0 11.5 7.4 8.6 7.8 5.8 8.2 11.8 12.1 8.5 10.4 7.6 8.1 7.5 8.3 18.4 6.3 8.6 7.3 8.5 10.1 21.4 8.6 7.4 10.3 8.8 10.1 7.4 8.5 10.4 10.2 4.2 8.1 8.9 14.9 11.9 8.6 9.6 6.1 10.3 15.8 13.2 10.2 8.8 11.8 15.0 13.3 16.9 12.4 8.9 7.7 5.9 17.9 14.7 24.3 14.4 17.1 5.6 15.3 10.5 16.3 15.5 8.3 9.9 11.1 9.2 14.9 18.1 19.7 10.4 16.0 14.9 19.0 10.2 12.7 10.8 15.9 16.4 17.6 16.5 10.2 8.8 8.4 15.6 10.3 10.8 11.9 15.6 13.4 22.6 6.8 10.0 22.9 13.0 13.5 9.0 8.0 8.7 15.7 0.5 6.0 27.0 18.9 13.8 14.9 15.8 18.3 12.7 11.5 9.3 1.8 2.6 3.3 1.5 3.0 3.1 2.4 3.6 1.0 4.0 2.7 1.9 5.6 2.4 2.9 2.9 1.8 1.5 6.5 7.5 6.8 7.0 5.8 8.2 7.6 8.1 7.3 8.5 8.1 10.3 50.0 80.1 91.6 26.4 42.1 26.6 36.3 35.0 28.5 72.1 29.7 19.9 44.5 44.3 55.2 53.3 95.9 17.9 41.7 122.9 27.4 36.0 2.7 38.4 44.9 55.0 47.4 23.5 30.0 54.0 30.0 38.4 39.8 50.4 60.7 30.9 64.2 85.8 29.0 75.7 34.9 62.2 26.4 43.6 33.0 4.1 42.6 44.2 8.8 29.0 45.8 45.8 55.6 32.6 41.9 65.4 53.5 51.6 39.5 53.0 59.2 59.8 50.6 133.7 65.7 43.6 34.9 15.2 21.0 30.8 35.5 38.0 40.8 30.0 48.0 68.1 XXYLT1 "C3orf21, FLJ35155" ENSG00000173950 "Xyloside xylosyltransferase 1" Q8NBI6 3 195068284-195271159 "Enzymes, Predicted intracellular proteins" "Glycosyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Inhibitory neurons: 30.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in many" "plasmacytoid DC: 10.0" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" NA NA 110000 "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 11: Squamous epithelial cells - Epithelial cell function" "Cluster 23: AN3-CA - Transcription regulation" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "unprognostic (1.39e-2)" "unprognostic (2.31e-2)" "unprognostic (3.42e-2)" "unprognostic (2.32e-3)" "unprognostic (9.57e-2)" "unprognostic (2.34e-1)" "unprognostic (6.29e-3)" "unprognostic (5.67e-2)" "unprognostic (5.50e-2)" "unprognostic (6.57e-2)" "unprognostic (3.13e-2)" "unprognostic (4.13e-1)" "prognostic unfavorable (1.70e-4)" "unprognostic (1.07e-1)" "unprognostic (2.23e-2)" "unprognostic (8.20e-2)" "unprognostic (1.07e-2)" 6.8 4.4 5.3 6.9 4.9 5.8 5.5 4.4 5.7 8.3 5.5 6.2 4.4 9.2 3.7 11.3 5.8 5.4 4.4 4.5 6.5 5.1 1.9 5.1 6.2 6.2 4.7 4.3 2.9 5.8 5.8 10.4 6.3 5.3 4.7 2.7 4.6 5.5 1.9 9.2 4.4 8.6 4.2 5.3 4.2 2.5 6.6 5.2 4.4 1.7 5.0 6.2 8.1 4.7 16.1 13.5 39.7 65.2 22.1 19.2 14.1 24.9 17.0 24.1 20.8 14.3 11.0 18.9 26.1 19.7 18.5 18.8 16.8 14.7 12.7 10.7 26.6 18.9 10.7 15.5 10.2 23.9 29.2 13.8 19.0 8.6 9.4 13.4 51.3 12.4 23.5 5.4 8.3 40.0 16.0 30.6 30.7 15.1 23.5 27.0 16.2 20.5 17.8 5.3 36.4 33.6 15.5 12.1 15.5 21.0 36.6 13.2 34.2 14.0 3.5 13.7 25.8 4.6 14.8 45.9 9.1 30.4 15.2 0.9 3.8 1.8 1.5 2.6 1.2 1.4 1.3 1.4 2.6 2.2 1.3 1.3 1.2 1.5 2.3 10.0 0.7 1.2 5.3 4.9 4.4 5.7 4.5 6.5 6.2 4.7 6.3 4.2 6.6 4.7 11.8 3.2 4.4 15.0 4.0 4.2 4.8 5.6 4.0 6.8 4.1 6.2 3.9 2.8 5.8 7.3 4.2 10.9 7.8 2.2 3.9 10.3 0.3 4.2 11.6 10.8 8.4 9.7 25.1 5.3 13.9 11.9 3.1 4.5 2.5 15.9 11.7 1.6 8.3 0.0 30.9 4.0 8.2 13.8 3.2 1.9 6.5 11.8 0.0 26.2 9.9 4.4 10.3 20.6 17.4 8.4 0.5 10.5 2.6 6.6 1.4 5.3 4.8 3.2 6.6 5.0 8.6 1.0 6.1 13.0 7.1 4.8 4.4 10.3 4.3 4.9 XYLB "FLJ10343, FLJ12539" ENSG00000093217 Xylulokinase O75191 3 38346760-38421348 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Carbohydrate metabolism, Xylose metabolism" "Kinase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "liver: 33.4" "Cell type enhanced" "Detected in many" "Excitatory neurons: 39.3;Hepatocytes: 49.3;Inhibitory neurons: 35.9;Proximal tubular cells: 31.7" "Low cancer specificity" "Detected in many" "Region enhanced" "Detected in many" "cerebellum: 5.4" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in some" "Low region specificity" "Detected in all" "HPA037863, HPA038415" Uncertain Approved "Nuclear speckles" NA NA 12000 "Cluster 45: Eosinophils - Innate immune response" "Cluster 85: Liver - Metabolism" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 67: Proximal tubular cells - Tubular reabsorption" "Nuclear speckles" "HPA037863: AB_10672729, HPA038415: AB_10672592" "unprognostic (2.48e-1)" "unprognostic (9.72e-2)" "unprognostic (3.42e-2)" "unprognostic (6.25e-2)" "unprognostic (7.52e-2)" "unprognostic (5.19e-2)" "unprognostic (5.82e-2)" "unprognostic (1.26e-3)" "unprognostic (6.55e-2)" "unprognostic (2.22e-1)" "unprognostic (6.91e-3)" "unprognostic (4.63e-2)" "prognostic favorable (8.57e-4)" "unprognostic (3.26e-1)" "unprognostic (2.06e-1)" "unprognostic (5.78e-2)" "unprognostic (3.37e-2)" 1.4 2.3 1.3 1.5 1.0 2.2 3.0 5.4 2.0 1.6 0.0 4.1 5.8 1.9 0.8 1.9 1.1 1.6 0.5 0.9 0.7 11.4 33.4 0.7 1.0 0.9 0.2 2.2 2.5 1.1 0.8 0.9 1.1 1.6 4.6 2.1 5.3 0.9 0.6 1.5 6.4 1.4 0.0 1.0 3.5 1.0 0.9 1.6 0.7 0.5 0.8 1.2 1.3 0.6 3.5 6.4 2.8 6.7 4.2 4.3 6.3 5.9 2.0 4.5 4.4 8.2 3.6 3.7 1.4 7.6 5.4 2.5 8.1 2.5 5.6 5.0 6.2 7.5 5.0 24.1 2.2 10.1 7.7 3.0 5.2 5.8 2.7 1.9 4.7 8.5 18.0 6.2 5.0 2.4 8.3 1.4 3.8 8.9 7.9 4.2 5.5 5.0 0.6 6.3 3.6 3.2 3.7 16.0 12.7 2.4 7.2 6.1 2.6 9.0 7.3 15.6 2.5 3.5 6.6 8.5 5.4 9.1 7.2 1.4 0.9 2.0 0.6 1.6 0.5 0.2 0.5 0.3 1.7 0.3 0.6 0.6 1.9 0.5 1.4 0.6 1.5 0.4 1.3 1.0 5.4 2.0 0.9 0.7 0.9 0.2 1.1 0.0 0.9 0.6 1.0 0.0 1.3 14.0 0.9 0.9 2.1 1.8 6.8 3.2 3.0 3.4 1.1 2.8 1.5 0.0 0.0 4.3 1.7 3.8 1.9 1.0 0.5 0.4 3.5 1.8 0.0 3.4 39.3 3.0 3.8 2.3 8.6 1.0 0.0 1.3 1.1 49.3 4.0 0.0 35.9 5.7 2.0 1.0 3.7 1.0 1.5 2.0 0.0 17.8 1.0 0.4 0.0 17.1 17.7 1.3 5.8 1.9 1.6 1.7 13.0 31.7 1.3 5.1 0.0 2.4 1.4 0.5 2.7 4.1 0.9 1.4 0.8 1.8 5.1 2.1 XYLT1 "PXYLT1, XT-I" ENSG00000103489 "Xylosyltransferase 1" Q86Y38 16 17101769-17470960 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted secreted proteins" "Glycosyltransferase, Transferase" "Disease variant, Dwarfism" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enriched" "Detected in many" 6 "Oligodendrocyte precursor cells: 1194.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "non-classical monocyte: 2.0" "Lineage enriched" "Detected in single" 4 "monocytes: 2.0" "Cell line enhanced" "Detected in many" "ASC diff: 55.1;ASC TERT1: 34.0;U-2197: 57.2" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA007478, HPA007966" Approved Approved "Endoplasmic reticulum,Plasma membrane" "Secreted to blood" NA NA 150000 "Cluster 14: Monocytes - Unknown function" "Cluster 10: Brain - Neuronal signaling" "Cluster 18: U-2197 - ECM organization" "Cluster 68: Oligodendrocytes - Mixed function" "Plasma membrane" "Endoplasmic reticulum" "HPA007478: AB_1080616, HPA007966: AB_1080618" "unprognostic (1.82e-1)" "unprognostic (7.17e-2)" "unprognostic (1.63e-1)" "unprognostic (1.38e-2)" "unprognostic (2.83e-1)" "unprognostic (9.12e-2)" "unprognostic (8.13e-2)" "unprognostic (9.40e-2)" "unprognostic (2.41e-3)" "unprognostic (2.82e-2)" "unprognostic (2.11e-1)" "unprognostic (1.01e-1)" "unprognostic (8.66e-3)" "unprognostic (2.49e-1)" "unprognostic (1.76e-1)" "unprognostic (2.95e-1)" "unprognostic (6.05e-2)" 6.4 6.2 6.2 4.9 8.0 7.2 4.5 2.3 6.3 7.8 8.5 8.8 4.3 7.9 1.0 5.1 3.7 2.3 4.2 8.8 3.6 1.0 0.3 3.5 5.1 3.7 4.3 5.3 2.8 0.9 0.6 6.0 4.2 2.7 5.2 8.3 2.5 4.5 1.1 5.0 5.3 5.7 1.6 5.4 3.4 2.3 3.6 4.1 2.2 1.2 4.3 4.3 4.6 4.6 0.0 0.3 8.0 0.1 55.1 34.0 9.6 25.6 12.9 2.7 1.0 0.3 0.6 6.1 0.0 31.3 0.9 0.6 0.0 5.1 4.5 12.1 0.6 8.0 0.0 0.0 0.6 11.5 10.2 12.6 0.7 15.0 2.4 4.6 0.0 0.3 0.0 23.8 2.8 0.8 0.1 12.4 8.5 4.4 0.0 3.5 0.0 1.2 0.0 11.5 2.0 15.2 1.9 7.9 1.4 5.9 1.9 7.2 0.0 24.6 2.9 57.2 0.0 26.4 1.4 11.6 28.9 12.8 22.4 0.3 0.2 0.4 0.2 1.2 0.3 0.1 0.1 0.1 0.4 0.3 0.2 0.1 0.1 0.4 2.0 0.1 0.3 0.2 6.2 8.0 2.3 6.3 8.8 3.6 3.7 4.3 4.2 1.6 3.6 4.6 1.0 3.2 2.5 45.4 9.2 7.9 1.6 0.0 1.2 12.9 3.8 3.7 3.4 0.0 0.7 0.0 98.0 12.7 12.4 9.1 0.0 1.5 0.5 0.5 24.7 2.9 12.6 7.4 172.8 1.6 20.1 12.2 2.6 0.8 2.5 6.4 1.4 0.2 3.5 0.0 72.8 4.3 4.1 9.7 27.6 0.8 12.8 8.5 3.6 29.0 6.1 1.9 11.3 1194.8 63.0 4.0 7.4 50.0 6.2 5.3 6.1 0.2 0.0 4.4 6.6 7.9 5.9 0.3 1.6 4.1 18.5 13.1 7.7 8.1 6.9 6.4 XYLT2 "PXYLT2, XT-II" ENSG00000015532 "Xylosyltransferase 2" Q9H1B5 17 50346126-50363138 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins" "Glycosyltransferase, Transferase" "Disease variant" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in all" 6 "stomach 1: 86.7" "Group enriched" "Detected in many" 6 "Early spermatids: 316.4;Late spermatids: 91.4" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "Secreted to blood" NA NA 1100000 "Cluster 39: Non-specific - mRNA processing" "Cluster 4: Stomach - Digestion" "Cluster 44: HDLM-2 - Immune response" "Cluster 29: Early spermatids - Spermatogenesis" "unprognostic (1.52e-1)" "unprognostic (2.84e-1)" "unprognostic (1.65e-1)" "unprognostic (8.07e-2)" "unprognostic (1.90e-3)" "unprognostic (1.90e-1)" "unprognostic (7.29e-3)" "unprognostic (2.52e-2)" "unprognostic (1.92e-1)" "unprognostic (2.30e-1)" "unprognostic (1.54e-2)" "unprognostic (2.81e-1)" "unprognostic (7.63e-2)" "unprognostic (5.15e-2)" "unprognostic (7.38e-2)" "unprognostic (1.52e-2)" "unprognostic (2.68e-2)" 7.4 9.7 4.9 6.6 5.2 4.5 8.1 8.0 8.2 12.3 8.7 10.0 9.6 11.4 5.3 8.4 11.8 6.6 9.1 5.6 3.0 8.9 7.5 7.3 9.3 4.1 5.6 13.6 12.9 9.4 6.4 8.6 3.8 13.6 3.6 4.5 12.2 10.1 5.8 15.3 8.7 5.2 2.5 10.1 86.7 6.7 7.0 8.6 9.3 2.4 4.0 12.0 10.9 5.3 21.1 26.2 7.0 5.9 9.7 9.4 18.4 19.3 17.4 17.2 19.1 28.3 15.5 10.9 47.6 17.3 14.9 15.8 2.4 27.0 3.7 54.3 18.5 24.6 8.6 12.4 13.3 7.8 12.5 12.8 16.4 13.6 6.3 16.9 14.9 9.4 4.4 8.8 11.3 27.5 14.4 10.7 6.5 14.0 18.0 7.2 20.4 9.0 9.5 10.8 3.6 9.0 12.9 11.9 20.3 8.0 57.4 7.5 17.4 38.4 19.2 20.9 17.3 48.0 23.6 3.9 40.4 12.3 10.6 3.7 2.0 1.5 2.7 1.2 2.7 1.3 2.7 3.6 2.4 2.2 2.7 2.5 1.9 3.6 1.1 1.6 2.5 2.9 4.9 5.2 8.0 8.2 5.6 3.0 4.1 5.6 3.8 2.5 7.0 5.3 7.5 9.6 6.1 13.1 3.9 5.7 3.2 7.3 5.7 8.3 3.9 5.7 8.4 10.0 4.4 1.8 29.2 7.0 3.8 7.5 0.0 7.1 316.4 4.6 6.7 6.8 10.8 0.8 4.9 6.2 5.4 9.1 17.3 6.8 1.3 9.6 10.4 8.0 3.6 6.7 7.2 9.4 2.0 6.0 1.4 91.4 12.5 3.8 7.2 6.5 2.7 5.9 5.2 6.6 4.7 6.8 3.5 17.3 4.7 2.0 4.6 2.8 3.2 6.1 26.3 6.9 6.7 2.4 4.3 3.4 3.1 1.5 4.8 5.3 11.1 1.4 YES1 "c-yes, HsT441, Yes" ENSG00000176105 "YES proto-oncogene 1, Src family tyrosine kinase" P07947 18 721588-812546 "Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Kinase, Transferase, Tyrosine-protein kinase" "FDA approved drug targets, Proto-oncogene" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 9 "basophil: 20.2" "Lineage enriched" "Detected in many" 9 "granulocytes: 20.2" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB004370, HPA026480" Approved Supported "Plasma membrane,Cytosol" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 86: Liver & Placenta - Transport via ER" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 14: Adipocytes & Endothelial cells - Angiogenesis" "Plasma membrane, Cytosol" "CAB004370: AB_627370, HPA026480: AB_1858921" "unprognostic (3.28e-1)" "unprognostic (1.62e-2)" "unprognostic (5.87e-2)" "unprognostic (2.47e-2)" "unprognostic (6.24e-2)" "unprognostic (4.24e-2)" "unprognostic (6.01e-2)" "unprognostic (1.03e-2)" "unprognostic (1.95e-2)" "unprognostic (1.85e-3)" "prognostic unfavorable (2.46e-4)" "unprognostic (2.14e-1)" "unprognostic (8.12e-2)" "unprognostic (4.65e-2)" "unprognostic (1.81e-1)" "unprognostic (4.79e-2)" "unprognostic (4.11e-1)" 25.2 13.5 11.9 10.5 12.7 4.1 21.8 12.7 14.3 17.4 11.5 21.8 24.8 16.0 17.9 22.7 13.9 18.9 13.1 11.7 13.7 27.9 50.6 17.2 6.2 13.9 13.2 12.4 26.5 20.0 6.1 41.7 13.5 15.0 22.7 8.3 21.0 11.9 8.3 16.7 23.7 15.9 14.2 27.4 21.3 19.0 14.3 10.5 22.0 14.6 8.8 20.3 11.5 14.1 42.7 20.8 64.3 50.6 37.8 46.5 75.6 27.9 56.2 32.0 43.7 49.9 30.7 0.1 28.8 47.3 41.0 24.3 60.8 49.1 62.3 0.2 20.7 12.6 19.4 35.1 30.6 9.9 21.7 35.7 51.7 48.5 53.6 39.8 109.8 7.0 56.1 18.4 46.1 29.3 6.0 13.0 40.9 26.0 26.4 7.4 50.6 3.6 46.8 49.6 13.1 15.3 57.5 42.9 37.1 42.3 29.7 20.5 95.6 78.4 86.2 59.9 75.8 15.7 8.3 2.6 29.7 13.8 47.6 20.2 0.0 1.0 2.2 0.0 1.5 0.1 0.4 1.2 0.0 0.0 1.0 1.7 0.0 1.1 0.0 0.0 0.1 0.6 11.9 12.7 12.7 14.3 11.7 13.7 13.9 13.2 13.5 14.2 14.3 14.1 120.3 25.6 36.8 18.9 3.3 60.2 46.8 21.4 50.1 6.0 38.1 26.7 18.2 24.3 31.3 29.5 6.2 37.1 52.9 40.3 3.9 29.6 29.4 32.8 35.0 91.0 22.8 12.0 0.4 39.2 26.6 35.4 57.6 43.6 13.9 35.9 39.7 44.9 4.9 3.3 10.3 37.2 14.2 5.4 14.7 11.7 18.3 5.0 24.9 46.9 2.0 16.8 16.5 31.7 30.2 51.0 28.8 12.8 28.9 65.4 33.1 45.6 29.0 8.6 19.7 35.9 23.8 20.3 13.6 53.1 49.7 45.6 27.5 42.4 36.7 66.6 ZAP70 "SRK, STD, ZAP-70" ENSG00000115085 "Zeta chain of T cell receptor associated protein kinase 70" P43403 2 97713576-97739862 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted intracellular proteins, RAS pathway related proteins" "Adaptive immunity, Immunity" "Kinase, Transferase, Tyrosine-protein kinase" "Disease variant, SCID" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "bone marrow: 24.8;lymphoid tissue: 79.9" "Group enriched" "Detected in many" 4 "dendritic cells: 101.0;NK-cells: 155.5;T-cells: 105.6" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in some" "Group enriched" "Detected in many" 41 "gdT-cell: 137.4;MAIT T-cell: 93.2;memory CD4 T-cell: 71.7;memory CD8 T-cell: 108.3;naive CD4 T-cell: 50.8;naive CD8 T-cell: 79.8;NK-cell: 112.2;T-reg: 80.1" "Group enriched" "Detected in many" 56 "NK-cells: 112.2;T-cells: 137.4" "Group enriched" "Detected in some" 11 "JURKAT: 121.0;MOLT-4: 183.4" "Low region specificity" "Detected in many" "Low region specificity" "Detected in all" "CAB002625, HPA003134" Enhanced NA NA 14000 "Cluster 36: GdT-cells - Adaptive immune response" "Cluster 3: T-cells - Adaptive immune response" "Cluster 22: JURKAT & MOLT-4 - Adaptive immune response" "Cluster 63: NK-cells & T-cells - Immune response" "CAB002625: , HPA003134: AB_1080629" "unprognostic (4.11e-3)" "prognostic favorable (6.89e-5)" "unprognostic (3.82e-3)" "prognostic favorable (9.66e-8)" "unprognostic (5.78e-2)" "prognostic favorable (3.93e-6)" "unprognostic (2.30e-3)" "unprognostic (1.09e-3)" "unprognostic (3.30e-1)" "unprognostic (1.37e-2)" "unprognostic (9.23e-3)" "unprognostic (2.70e-1)" "prognostic unfavorable (3.02e-8)" "unprognostic (1.29e-1)" "unprognostic (1.65e-1)" "unprognostic (6.40e-2)" "unprognostic (5.83e-3)" 3.3 1.3 0.5 28.0 0.6 24.8 1.9 0.5 0.9 1.7 0.7 4.0 5.8 1.4 0.5 2.3 2.2 5.4 1.4 0.5 0.7 2.8 3.9 8.7 57.0 0.8 1.3 0.8 1.0 0.4 1.1 0.9 0.7 2.5 1.5 0.0 2.3 0.8 2.0 2.4 18.5 0.5 0.6 35.5 6.7 2.7 1.2 79.9 3.5 2.8 17.7 4.9 2.5 0.6 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 1.8 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.4 0.0 0.1 0.2 0.0 0.0 0.0 0.0 0.1 0.0 121.0 0.0 0.7 0.0 0.0 183.4 0.5 0.1 0.0 0.0 7.2 0.1 9.1 0.0 0.0 0.2 0.2 0.0 0.2 0.1 0.6 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.1 14.1 0.1 0.0 0.0 0.3 0.3 0.5 137.4 0.4 93.2 0.2 71.7 108.3 0.3 1.6 50.8 79.8 2.2 112.2 1.0 0.9 80.1 64.2 0.5 0.6 0.5 0.9 0.5 0.7 0.8 1.3 0.7 0.6 1.2 0.6 0.8 9.6 13.6 0.3 3.9 1.5 0.0 0.0 0.0 0.0 0.8 0.5 3.0 0.0 0.0 0.0 0.0 0.1 101.0 0.2 1.9 0.2 1.0 1.6 0.5 0.8 0.0 8.8 0.2 0.0 0.0 1.8 4.6 0.4 2.5 0.1 2.5 0.7 2.2 0.0 0.2 0.0 0.0 2.8 2.2 0.7 0.0 3.4 1.8 2.8 5.0 0.0 155.5 0.0 0.1 0.0 0.0 0.0 28.0 0.1 0.0 0.5 0.0 0.0 0.0 14.3 0.6 1.3 2.1 0.2 1.4 0.0 105.6 0.1 0.1 0.2 ZDHHC1 "C16orf1, HSU90653, ZNF377" ENSG00000159714 "Zinc finger DHHC-type containing 1" Q8WTX9 16 67394152-67416833 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Endometrial ciliated cells: 84.6;Late spermatids: 53.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "intermediate monocyte: 1.4;non-classical monocyte: 1.3" "Low lineage specificity" "Detected in single" "Cell line enhanced" "Detected in many" "ASC diff: 11.4;ASC TERT1: 11.3;U-138 MG: 11.7" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA042531, HPA048659" Uncertain Approved Cytosol NA NA "Cluster 7: Monocytes - Unknown function" "Cluster 72: Non-specific - Transcription" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 49: Ciliated cells - Cilium organization" Cytosol "HPA042531: AB_2678041, HPA048659: AB_2680483" "unprognostic (8.96e-2)" "unprognostic (1.43e-2)" "unprognostic (1.05e-3)" "prognostic favorable (1.25e-6)" "unprognostic (1.68e-2)" "unprognostic (9.33e-2)" "unprognostic (6.03e-2)" "unprognostic (1.82e-2)" "unprognostic (1.93e-1)" "unprognostic (2.67e-1)" "prognostic favorable (5.99e-4)" "unprognostic (2.17e-1)" "prognostic favorable (1.55e-6)" "unprognostic (2.10e-1)" "unprognostic (1.59e-1)" "unprognostic (1.46e-1)" "unprognostic (5.63e-3)" 17.7 10.9 3.7 1.8 3.5 0.2 17.9 3.2 5.6 27.1 7.4 14.5 2.3 21.7 3.9 6.8 22.4 6.3 10.8 3.4 4.2 19.3 4.4 12.4 1.4 4.9 6.7 23.6 17.7 7.8 20.4 3.1 4.1 19.5 1.7 0.8 17.0 6.7 10.7 19.1 7.4 3.9 4.7 14.9 10.6 20.3 4.4 0.6 29.4 3.0 0.8 12.8 16.3 2.8 5.2 6.0 1.4 7.3 11.4 11.3 0.0 3.2 9.0 2.6 2.8 0.0 2.6 0.0 1.3 4.2 2.5 3.3 0.4 0.6 0.5 1.6 4.6 0.5 0.1 0.4 5.2 0.2 4.0 6.0 5.3 2.7 0.6 6.0 3.3 0.0 0.0 0.0 1.8 0.3 0.0 0.0 2.9 1.8 0.1 0.0 0.0 0.0 3.5 2.9 2.1 7.4 0.5 0.1 6.5 0.4 1.9 1.1 5.8 11.7 2.0 5.6 3.3 1.4 0.3 0.0 7.2 0.1 4.7 0.0 1.0 0.0 0.0 1.4 0.0 0.0 0.0 0.0 0.8 0.0 0.0 0.0 0.1 0.0 1.3 0.0 0.0 0.3 3.7 3.5 3.2 5.6 3.4 4.2 4.9 6.7 4.1 4.7 4.4 2.8 7.0 0.0 0.0 10.4 0.9 7.1 6.7 1.3 10.8 2.2 7.5 7.0 1.1 10.0 1.4 7.3 4.2 2.0 0.3 5.2 9.8 3.4 29.3 84.6 10.9 5.2 9.0 0.4 5.7 4.0 0.2 13.6 8.6 7.3 0.0 8.5 6.1 2.0 2.0 3.3 5.0 12.9 2.0 16.4 6.8 53.0 14.6 9.3 5.4 2.8 8.2 7.9 1.0 4.0 2.5 2.2 4.9 10.9 0.7 7.2 2.0 6.6 5.5 0.5 0.0 5.1 9.4 12.4 8.6 6.2 7.1 5.7 0.7 10.4 6.8 4.8 ZDHHC11 "FLJ13153, ZNF399" ENSG00000188818 "Zinc finger DHHC-type containing 11" Q9H8X9 5 795606-850986 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Alveolar cells type 1: 19.2;Early spermatids: 17.0;Endometrial ciliated cells: 26.2;Excitatory neurons: 21.4;Inhibitory neurons: 16.4;Oligodendrocytes: 18.3;Respiratory ciliated cells: 25.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "T-47d: 11.5" "HPA057886, HPA069008" Uncertain Approved Mitochondria NA NA "Cluster 43: Testis - Unknown function" "Cluster 5: NTERA-2 - Transcription" "Cluster 49: Ciliated cells - Cilium organization" Mitochondria "HPA057886: AB_2683548, HPA069008: AB_2686068" "unprognostic (2.67e-1)" "unprognostic (9.76e-3)" "unprognostic (4.47e-5)" "unprognostic (5.43e-2)" "unprognostic (7.46e-2)" "unprognostic (4.68e-2)" "unprognostic (3.71e-2)" "unprognostic (1.49e-2)" "unprognostic (1.01e-2)" "unprognostic (2.32e-1)" "unprognostic (2.28e-2)" "unprognostic (2.65e-1)" "unprognostic (5.23e-5)" "unprognostic (4.80e-2)" "unprognostic (3.98e-1)" "unprognostic (1.86e-2)" "unprognostic (3.51e-2)" 1.9 0.9 8.0 0.4 9.9 0.5 2.1 8.3 13.0 2.7 8.0 3.5 6.1 1.1 1.8 3.9 6.5 0.9 9.0 7.4 5.1 4.1 5.2 4.7 0.5 7.9 9.9 1.7 2.8 0.6 12.0 0.8 9.0 2.8 0.8 4.3 2.7 0.9 2.0 3.1 2.9 0.5 2.3 3.3 4.4 10.4 7.1 0.7 2.4 2.2 0.7 2.4 2.2 15.0 0.4 7.4 4.1 0.9 1.3 0.3 5.4 0.3 0.1 0.2 0.1 1.0 0.3 3.1 0.8 0.0 0.9 7.1 2.6 0.0 0.0 9.6 4.9 0.3 3.0 3.9 0.4 4.5 0.3 0.4 0.3 0.9 1.0 0.3 0.0 1.2 0.7 1.7 0.2 3.5 0.4 2.5 7.3 0.0 2.8 4.6 2.7 4.3 0.2 1.5 4.2 0.8 0.2 0.1 3.5 8.0 11.5 0.8 0.4 0.2 6.9 3.9 0.1 5.6 8.3 0.9 0.3 9.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 8.0 9.9 8.3 13.0 7.4 5.1 7.9 9.9 9.0 2.3 7.1 15.0 0.7 19.2 13.1 8.5 0.0 1.9 0.4 0.6 0.0 3.4 1.6 2.0 7.7 1.5 13.4 0.0 0.0 0.2 0.3 1.2 0.0 0.5 17.0 26.2 3.8 1.5 1.8 0.4 21.4 0.0 0.1 3.6 4.1 4.2 3.8 0.1 1.1 2.7 0.4 6.7 16.4 3.9 0.0 0.0 0.3 9.1 0.6 0.9 0.0 0.0 0.1 0.3 0.0 7.5 18.3 0.2 1.7 0.0 1.4 0.3 6.0 1.3 25.8 2.2 6.6 0.9 1.0 9.5 3.7 0.7 1.6 0.3 1.1 0.1 1.6 0.4 ZDHHC11B ENSG00000206077 "Zinc finger DHHC-type containing 11B" P0C7U3 5 710355-784729 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "No human protein/transcript evidence" "Evidence at transcript level" "Tissue enriched" "Detected in many" 6 "brain: 29.5" "Cell type enhanced" "Detected in many" "Alveolar cells type 2: 23.0;Excitatory neurons: 47.2;Inhibitory neurons: 38.3;Oligodendrocyte precursor cells: 26.7;Oligodendrocytes: 70.1;Respiratory ciliated cells: 21.8" "Low cancer specificity" "Detected in many" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HAP1: 2.1;SCLC-21H: 2.4;THP-1: 3.4" "HPA057886, HPA069008" Uncertain Approved Mitochondria NA NA "Cluster 65: Brain - Ion transport" "Cluster 43: THP-1 - Innate immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Mitochondria "HPA057886: AB_2683548, HPA069008: AB_2686068" "unprognostic (2.81e-1)" "unprognostic (8.38e-3)" "unprognostic (3.79e-2)" "unprognostic (5.11e-3)" "unprognostic (7.18e-2)" "unprognostic (4.02e-3)" "unprognostic (1.19e-1)" "prognostic favorable (3.98e-4)" "unprognostic (4.39e-3)" "unprognostic (1.29e-1)" "unprognostic (1.45e-4)" "unprognostic (6.94e-2)" "unprognostic (1.43e-2)" "unprognostic (9.21e-2)" "unprognostic (1.73e-1)" "unprognostic (5.13e-2)" "unprognostic (2.31e-1)" 0.7 1.2 15.1 0.2 19.6 0.0 0.8 5.9 19.9 0.5 0.0 2.0 2.7 0.4 0.1 1.5 2.0 0.3 4.5 14.6 9.0 0.7 1.2 2.4 0.0 14.2 8.6 0.6 1.8 0.4 4.5 0.2 14.9 0.5 2.3 4.3 1.7 0.5 3.6 2.2 2.4 0.4 3.3 1.2 2.3 0.7 15.5 0.0 1.1 1.6 0.3 1.0 0.6 29.5 0.0 0.8 0.0 0.7 0.0 0.3 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.1 0.6 2.1 0.1 0.0 0.3 0.4 0.0 0.2 0.0 0.2 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.6 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.4 2.4 0.4 0.0 0.0 0.7 0.3 0.0 3.4 0.0 0.0 0.6 0.0 0.0 0.8 0.5 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 15.1 19.6 5.9 19.9 14.6 9.0 14.2 8.6 14.9 3.3 15.5 29.5 0.2 19.2 23.0 17.0 0.0 2.7 1.0 0.1 2.2 7.0 1.1 0.9 8.9 1.5 5.7 3.7 0.0 0.0 0.4 2.0 0.0 0.8 2.5 11.9 0.7 2.8 3.0 0.0 47.2 0.8 0.1 4.7 4.1 3.6 1.3 0.0 0.7 2.3 1.7 10.1 38.3 6.7 0.0 0.6 1.1 0.4 0.9 0.8 0.0 1.9 0.0 0.6 0.0 26.7 70.1 0.1 1.4 0.0 1.7 0.3 7.7 0.5 21.8 0.3 6.6 1.4 2.4 5.0 2.5 2.3 3.1 0.0 1.5 0.5 2.4 2.6 ZDHHC12 "FLJ14524, ZNF400" ENSG00000160446 "Zinc finger DHHC-type palmitoyltransferase 12" Q96GR4 9 128720870-128724127 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at transcript level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Extravillous trophoblasts: 224.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" HPA059339 Uncertain Approved "Nucleoplasm,Intermediate filaments" No No "Cluster 31: Non-specific - Inflammatory response" "Cluster 29: Non-specific - Vesicular transport" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 53: Intestinal epithelial cells - Unknown function" Nucleoplasm "Intermediate filaments" "HPA059339: AB_2683985" "unprognostic (2.05e-1)" "unprognostic (5.81e-2)" "unprognostic (2.54e-1)" "unprognostic (1.53e-3)" "unprognostic (5.34e-3)" "unprognostic (3.11e-2)" "unprognostic (1.50e-3)" "unprognostic (6.56e-3)" "unprognostic (1.02e-1)" "unprognostic (6.42e-2)" "unprognostic (9.97e-2)" "unprognostic (9.41e-2)" "unprognostic (1.09e-2)" "unprognostic (8.82e-3)" "unprognostic (2.18e-1)" "unprognostic (1.95e-2)" "unprognostic (3.23e-1)" 18.8 23.9 7.8 15.5 7.7 41.3 19.3 7.5 9.9 16.8 8.4 40.5 26.3 12.9 7.1 67.8 12.0 14.1 13.7 7.4 8.8 30.6 52.3 23.3 20.0 9.6 7.8 7.4 67.1 9.8 11.3 16.3 8.4 26.6 13.7 0.5 43.2 12.5 15.6 42.4 36.8 6.3 8.4 31.7 49.2 24.7 10.5 12.4 16.2 4.1 13.7 18.7 30.5 9.7 53.5 127.6 6.0 31.3 17.6 12.1 59.4 32.8 28.8 34.5 22.9 109.6 61.5 37.3 29.6 25.5 62.9 139.8 13.0 65.0 3.8 65.0 31.7 20.1 92.7 49.1 34.7 33.1 87.1 19.9 44.7 29.6 11.0 17.7 25.6 65.6 18.8 93.6 7.1 187.3 45.9 66.2 26.8 118.8 107.6 21.0 21.0 108.4 28.7 43.4 42.1 30.4 46.2 64.1 18.3 9.6 98.9 35.6 27.5 0.1 36.9 25.9 45.8 58.1 106.8 17.3 61.3 38.4 41.4 231.1 122.3 385.6 105.1 123.9 91.2 94.6 95.9 101.5 100.1 111.0 99.2 91.4 269.5 90.5 150.0 244.7 130.9 101.0 7.8 7.7 7.5 9.9 7.4 8.8 9.6 7.8 8.4 8.4 10.5 9.7 10.0 16.0 12.0 1.3 31.8 16.2 43.3 94.0 10.8 1.2 55.5 30.4 14.8 77.2 59.0 46.0 0.0 183.9 39.1 171.0 13.7 106.8 73.2 20.7 11.5 21.1 51.2 51.1 0.6 200.0 224.0 14.2 38.7 52.5 18.4 13.7 35.7 55.3 137.0 0.0 0.5 108.5 67.1 62.2 20.9 30.0 9.6 46.5 42.7 6.5 115.3 18.4 81.4 0.5 2.0 133.8 167.7 7.2 43.3 56.5 186.0 48.5 20.1 2.0 6.6 5.4 16.3 36.0 18.6 55.2 28.1 134.1 34.1 22.0 110.0 77.5 ZDHHC13 "FLJ10852, FLJ10941, HIP14L" ENSG00000177054 "Zinc finger DHHC-type palmitoyltransferase 13" Q8IUH4 11 19117099-19176422 "Enzymes, Metabolic proteins, Predicted membrane proteins, Transporters" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 120.5;Urothelial cells: 103.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Cell line enhanced" "Detected in all" "HUVEC TERT2: 136.8" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016759, HPA018791" Uncertain Supported "Golgi apparatus,Vesicles" NA NA "Cluster 45: Eosinophils - Innate immune response" "Cluster 37: Intestine - Unknown function" "Cluster 41: TIME & HUVEC/TERT2 - Endothelial cell function" "Cluster 22: Epithelial cell types - Mixed function" Vesicles "Golgi apparatus" "HPA016759: AB_1858993, HPA018791: AB_1858992" "unprognostic (1.43e-2)" "unprognostic (4.00e-3)" "unprognostic (1.08e-1)" "unprognostic (1.11e-3)" "unprognostic (2.95e-2)" "unprognostic (1.34e-2)" "unprognostic (1.55e-2)" "unprognostic (1.57e-1)" "unprognostic (3.57e-3)" "unprognostic (3.03e-2)" "unprognostic (1.63e-1)" "unprognostic (2.16e-1)" "unprognostic (6.95e-3)" "unprognostic (1.15e-1)" "unprognostic (7.93e-2)" "unprognostic (2.17e-1)" "unprognostic (2.76e-2)" 4.8 5.7 5.2 7.8 5.2 9.7 8.9 6.6 7.1 9.3 6.6 16.9 11.2 6.7 5.1 37.2 12.9 8.7 9.1 5.4 5.7 9.2 2.2 6.1 9.6 5.5 5.0 5.3 11.2 14.9 11.7 6.2 5.8 8.2 18.2 16.1 10.2 5.4 1.6 18.8 11.3 6.1 5.3 5.7 18.5 14.4 5.0 11.7 8.7 2.9 22.4 22.4 15.4 5.2 41.6 19.3 18.0 15.5 6.3 7.2 17.3 19.4 17.8 21.3 24.4 11.7 9.7 21.1 13.1 16.3 47.9 61.3 26.0 12.8 23.3 26.4 22.6 11.1 12.6 9.7 14.6 15.2 18.5 8.3 14.7 9.0 12.5 19.9 136.8 28.9 10.7 10.3 22.1 13.5 19.6 12.2 15.1 38.7 17.6 21.3 25.0 5.0 21.9 27.0 31.3 23.0 23.2 28.0 10.7 17.3 13.2 17.6 39.6 18.9 13.2 29.2 15.8 8.7 28.5 19.2 22.6 15.5 33.6 11.6 4.7 32.7 8.5 7.9 7.8 8.7 6.6 9.6 5.9 5.5 6.2 8.3 6.0 6.3 6.4 5.6 9.4 4.6 5.2 5.2 6.6 7.1 5.4 5.7 5.5 5.0 5.8 5.3 5.0 5.2 8.1 9.6 10.7 28.7 9.6 24.2 22.3 27.2 14.2 12.0 7.5 4.8 34.1 12.8 41.3 16.5 10.4 8.7 10.6 20.1 5.9 25.1 120.5 21.5 6.6 11.3 15.6 11.6 27.2 19.2 18.8 9.2 24.5 30.8 12.0 16.2 12.8 0.9 6.1 16.8 34.9 24.7 36.7 6.8 8.3 46.6 7.8 6.2 3.6 9.4 20.8 52.8 18.6 19.6 20.9 20.4 16.4 2.2 10.4 47.4 15.5 3.5 57.0 8.8 0.0 5.4 7.4 58.1 31.7 21.3 36.2 6.3 11.4 7.7 21.4 103.0 ZDHHC14 "FLJ20984, NEW1CP" ENSG00000175048 "Zinc finger DHHC-type palmitoyltransferase 14" Q8IZN3 6 157381133-157678157 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 22.7" "Cell type enhanced" "Detected in many" "Excitatory neurons: 161.7;Horizontal cells: 122.8;Inhibitory neurons: 108.1;Oligodendrocyte precursor cells: 315.2;Oligodendrocytes: 221.0" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in single" "plasmacytoid DC: 1.3" "Low lineage specificity" "Detected in single" "Cell line enriched" "Detected in many" 4 "HDLM-2: 50.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA013437, HPA063754" Approved Uncertain Vesicles NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 70: Brain - Nervous system development" "Cluster 44: HDLM-2 - Immune response" "Cluster 42: Oligodendrocytes - Myelin sheath organization" Vesicles "HPA013437: , HPA063754: AB_2685113" "unprognostic (1.66e-2)" "unprognostic (1.27e-2)" "unprognostic (1.58e-2)" "unprognostic (3.98e-2)" "unprognostic (1.59e-1)" "unprognostic (6.78e-3)" "unprognostic (1.84e-1)" "unprognostic (6.02e-2)" "unprognostic (2.87e-2)" "unprognostic (1.63e-1)" "prognostic favorable (6.93e-4)" "unprognostic (3.94e-2)" "unprognostic (5.01e-3)" "unprognostic (1.89e-1)" "unprognostic (7.95e-2)" "unprognostic (4.43e-1)" "unprognostic (2.63e-1)" 2.9 1.6 7.3 1.8 7.6 2.5 1.6 9.7 6.8 5.3 1.1 2.4 2.8 12.4 0.4 1.7 2.0 2.3 5.2 7.5 5.1 4.6 4.4 3.0 2.4 12.5 9.1 1.4 2.5 5.6 1.6 2.2 10.9 3.5 1.7 1.3 2.1 1.4 2.3 1.4 4.1 6.1 13.5 3.1 3.8 3.3 10.8 0.9 1.7 3.9 2.4 2.4 1.9 22.7 2.6 2.7 0.8 3.8 2.0 1.5 8.7 4.1 3.7 2.8 2.5 3.3 1.9 6.4 1.4 3.3 5.4 1.3 2.2 2.2 2.5 50.9 3.2 12.7 1.0 1.5 2.7 1.7 2.8 1.1 2.3 2.9 1.2 2.4 4.3 2.8 10.4 4.7 1.6 1.7 1.1 4.2 1.6 5.1 3.2 0.2 0.4 3.9 5.8 1.1 6.3 1.9 4.8 3.1 3.5 1.6 0.4 2.0 6.0 4.2 3.1 8.3 5.2 1.1 1.3 0.9 1.5 4.5 4.7 0.0 0.0 0.0 0.1 0.0 0.2 0.4 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.1 0.0 1.3 0.0 0.1 7.3 7.6 9.7 6.8 7.5 5.1 12.5 9.1 10.9 13.5 10.8 22.7 23.4 3.2 0.0 45.4 9.8 12.9 2.1 3.0 4.0 25.3 5.8 8.0 18.3 12.8 1.4 7.3 6.2 12.5 11.2 7.4 11.7 7.5 10.7 5.0 16.6 15.1 2.4 4.2 161.7 3.1 2.2 11.4 6.1 9.4 0.0 7.7 22.5 23.1 11.4 122.8 108.1 9.8 6.1 15.5 6.7 5.9 8.1 8.8 10.6 65.6 3.8 5.4 7.2 315.2 221.0 2.7 8.5 10.1 4.5 14.2 6.0 3.8 0.4 6.0 0.0 6.2 8.4 7.2 10.0 1.5 8.4 21.1 6.6 4.6 11.5 2.7 ZDHHC15 "DHHC15, FLJ31812, MRX91" ENSG00000102383 "Zinc finger DHHC-type palmitoyltransferase 15" Q96MV8 X 75368427-75523502 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Predicted membrane proteins" "Acyltransferase, Transferase" "Mental retardation" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Excitatory neurons: 18.2;Inhibitory neurons: 17.7;Oligodendrocyte precursor cells: 17.1" "Cancer enhanced" "Detected in some" "glioma: 2.9" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in some" "HEL: 3.2;K-562: 2.1;LHCN-M2: 2.2;MOLT-4: 2.4;NTERA-2: 2.0;RH-30: 3.1;RPTEC TERT1: 1.7;SH-SY5Y: 2.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA003618, HPA064901" Approved Approved "Nuclear speckles,Cytosol" NA NA "Cluster 21: Non-specific - Transcription" "Cluster 31: RH-30 & LHCN-M2 - Muscle contraction" "Cluster 8: Neurons & Oligodendrocytes - Synaptic function" "Nuclear speckles" Cytosol "HPA003618: AB_2217686, HPA064901: " "unprognostic (8.28e-2)" "unprognostic (1.73e-1)" "unprognostic (8.05e-2)" "unprognostic (1.62e-5)" "unprognostic (1.64e-2)" "unprognostic (1.00e-1)" "unprognostic (4.00e-4)" "unprognostic (1.96e-2)" "unprognostic (3.19e-1)" "unprognostic (8.70e-2)" "unprognostic (3.77e-3)" "unprognostic (1.40e-1)" "unprognostic (4.78e-13)" "unprognostic (2.60e-3)" "unprognostic (1.17e-2)" "unprognostic (1.09e-1)" "unprognostic (9.67e-4)" 0.8 1.5 1.7 0.3 1.7 0.1 1.6 1.8 1.5 1.6 1.3 1.0 0.2 1.9 1.0 0.8 1.2 0.8 1.7 1.5 2.5 1.5 0.2 1.2 0.3 2.2 2.2 2.5 1.1 1.1 1.1 0.0 2.0 1.1 0.5 1.9 4.5 1.1 0.3 0.7 0.3 1.5 1.8 0.8 0.4 0.6 3.0 0.8 2.0 0.5 0.2 0.7 0.8 2.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.6 0.0 0.0 0.0 0.0 3.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 1.4 2.1 0.0 2.2 0.0 2.4 0.0 2.0 0.0 0.0 0.0 3.1 0.0 1.7 0.0 0.8 2.6 0.0 0.0 0.0 1.1 0.0 0.0 0.0 0.2 0.5 0.0 0.4 1.6 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 1.7 1.7 1.8 1.5 1.5 2.5 2.2 2.2 2.0 1.8 3.0 2.0 2.9 6.4 3.1 8.5 0.1 4.0 1.6 0.0 3.4 4.2 2.0 1.5 9.5 1.5 1.3 5.5 4.2 0.0 0.3 0.0 0.0 0.7 0.0 0.2 2.9 3.5 1.8 0.4 18.2 0.7 0.0 3.5 0.0 0.3 1.3 2.5 2.2 0.1 0.1 0.0 17.7 0.0 0.0 0.0 4.4 0.2 0.9 0.1 0.0 5.6 0.0 2.2 1.0 17.1 9.1 0.2 0.0 3.8 0.0 0.7 0.0 1.0 0.0 2.3 6.6 5.4 2.5 0.2 0.7 2.2 3.7 0.0 0.5 2.3 0.0 0.6 ZDHHC16 APH2 ENSG00000171307 "Zinc finger DHHC-type palmitoyltransferase 16" Q969W1 10 97446170-97457370 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Apoptosis, DNA damage" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Extravillous trophoblasts: 67.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA039893, HPA040214" Uncertain Supported "Nucleoplasm,Nuclear membrane,Cytosol" NA NA "Cluster 26: Non-specific - Mitochondria" "Cluster 39: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 38: Extravillous trophoblasts - Unknown function" Nucleoplasm "Nuclear membrane, Cytosol" "HPA039893: AB_10794757, HPA040214: AB_2676886" "unprognostic (4.44e-2)" "unprognostic (3.14e-2)" "unprognostic (3.34e-1)" "unprognostic (1.20e-2)" "unprognostic (8.75e-2)" "unprognostic (8.35e-3)" "unprognostic (1.27e-2)" "unprognostic (3.62e-2)" "unprognostic (5.49e-2)" "unprognostic (1.57e-1)" "unprognostic (2.31e-1)" "unprognostic (6.34e-2)" "unprognostic (1.93e-3)" "unprognostic (1.34e-1)" "unprognostic (1.07e-1)" "unprognostic (1.28e-2)" "unprognostic (2.48e-1)" 15.6 14.9 17.8 10.2 18.5 6.8 16.3 20.3 21.9 15.0 16.4 17.1 14.3 16.4 18.5 19.9 12.2 9.9 22.1 18.1 16.5 25.1 30.3 20.8 11.3 17.2 17.8 15.9 22.8 25.5 16.7 21.6 16.4 18.3 17.3 17.4 24.2 12.1 25.8 13.1 14.7 16.6 16.1 14.5 24.1 17.3 18.8 12.6 16.0 27.9 15.1 17.1 15.3 16.7 50.7 57.4 37.9 47.1 58.7 40.4 38.7 54.6 72.1 61.2 58.4 45.7 43.6 44.4 60.1 79.8 53.4 58.0 48.2 76.7 54.2 43.7 56.0 28.5 39.8 44.3 47.4 34.0 39.7 45.7 49.8 71.6 51.3 66.3 63.9 40.4 23.1 32.8 79.0 48.4 51.8 46.0 29.9 45.8 49.5 34.0 38.6 40.9 51.9 23.2 18.4 25.9 33.2 33.7 30.6 37.7 44.6 32.9 39.6 38.2 35.0 25.0 64.7 29.2 53.0 26.9 44.1 51.7 20.7 0.3 11.1 11.1 7.2 11.9 8.1 9.0 12.5 11.5 15.7 10.6 10.0 10.1 0.5 14.5 11.8 12.0 11.1 6.8 17.8 18.5 20.3 21.9 18.1 16.5 17.2 17.8 16.4 16.1 18.8 16.7 6.2 19.2 23.1 3.9 9.0 5.2 18.9 31.8 14.8 15.8 13.6 9.3 10.1 14.3 27.6 12.9 4.2 39.8 10.3 11.5 25.4 35.5 24.8 7.0 13.3 11.3 7.2 11.6 8.2 32.3 67.2 13.7 10.2 10.9 7.0 13.3 7.5 19.5 24.6 13.5 9.2 18.9 28.5 7.3 5.9 7.6 8.7 9.3 3.6 9.4 18.4 14.9 15.5 11.1 8.4 31.5 12.1 3.8 17.1 20.0 18.9 22.2 8.3 13.0 6.6 5.2 12.2 20.1 12.9 13.8 4.3 37.9 7.2 10.9 20.9 19.3 ZDHHC17 "HIP14, HYPH, KIAA0946" ENSG00000186908 "Zinc finger DHHC-type palmitoyltransferase 17" Q8IUH5 12 76764103-76853696 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters" "Acyltransferase, Transferase" "Tumor suppressor" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Excitatory neurons: 102.2;Inhibitory neurons: 95.1;Oligodendrocytes: 115.8" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in all" "plasmacytoid DC: 17.1" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA016807, HPA058674" Approved Supported "Golgi apparatus,Vesicles" NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 6: Brain - Smell perception" "Cluster 12: NES - Nervous system development" "Cluster 65: Plasmacytoid DCs - Unknown function" "Golgi apparatus, Vesicles" "HPA016807: AB_1858999, HPA058674: AB_2732626" "unprognostic (1.06e-1)" "unprognostic (2.26e-2)" "unprognostic (2.63e-2)" "unprognostic (3.04e-1)" "unprognostic (6.12e-2)" "unprognostic (2.83e-2)" "unprognostic (2.35e-3)" "unprognostic (3.09e-1)" "unprognostic (8.38e-2)" "unprognostic (1.04e-1)" "unprognostic (1.56e-3)" "unprognostic (5.42e-2)" "prognostic unfavorable (7.11e-5)" "unprognostic (1.77e-2)" "unprognostic (2.69e-1)" "unprognostic (2.98e-1)" "unprognostic (1.71e-2)" 15.6 14.1 18.6 12.1 20.4 23.7 16.1 23.1 25.9 15.8 11.8 13.7 7.5 21.7 12.3 8.0 12.8 10.5 12.5 19.8 18.9 11.0 9.8 10.6 14.8 18.2 18.6 20.1 10.2 12.7 11.0 16.4 18.9 14.1 10.1 31.0 8.1 12.8 11.8 10.2 10.3 14.6 19.2 14.4 8.5 12.8 19.4 14.9 11.8 14.2 11.4 11.7 11.7 27.8 8.2 9.5 30.1 15.4 17.6 18.5 14.6 16.2 13.4 10.5 9.2 7.8 5.8 11.2 9.5 15.9 10.5 7.5 12.1 10.1 16.2 9.5 12.6 16.4 13.1 12.0 11.9 16.5 13.9 17.6 10.3 10.0 14.7 35.2 12.2 15.2 18.0 5.2 13.8 7.6 12.0 21.9 22.1 3.6 11.3 16.1 10.7 12.3 12.0 12.3 11.7 20.1 17.8 6.4 10.7 25.7 14.4 16.3 16.9 14.3 11.0 8.8 9.3 8.1 8.5 11.9 5.4 7.6 15.0 6.2 2.3 5.7 3.6 2.4 2.9 2.5 2.9 2.6 2.8 3.9 3.0 2.5 5.9 2.0 2.5 17.1 1.3 1.5 18.6 20.4 23.1 25.9 19.8 18.9 18.2 18.6 18.9 19.2 19.4 27.8 33.4 32.1 18.3 75.7 20.1 7.1 10.4 9.8 12.5 54.6 9.9 10.7 21.3 12.8 15.5 12.9 39.6 20.3 74.1 5.0 0.0 8.0 11.3 11.8 23.8 24.8 19.2 12.0 102.2 4.7 10.2 21.2 7.1 10.1 41.2 20.7 20.3 10.6 8.8 28.6 95.1 7.5 8.2 12.3 19.4 13.7 20.2 14.9 5.4 54.4 14.9 26.1 18.6 88.4 115.8 6.8 4.5 21.1 13.5 10.2 8.4 5.5 18.0 38.1 0.0 32.3 22.0 17.7 22.6 9.5 5.5 5.6 18.1 19.6 6.2 5.5 ZDHHC18 DKFZp667O2416 ENSG00000204160 "Zinc finger DHHC-type palmitoyltransferase 18" Q9NUE0 1 26826688-26857604 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "bone marrow: 113.9" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enriched" "Detected in many" 5 "neutrophil: 48.8" "Lineage enriched" "Detected in many" 18 "granulocytes: 48.8" "Cell line enhanced" "Detected in all" "HDLM-2: 132.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA040234 Approved Approved Microtubules NA NA "Cluster 9: Neutrophils - Innate immune response" "Cluster 76: Brain & Bone marrow - Chromatin organization" "Cluster 44: HDLM-2 - Immune response" "Cluster 53: Intestinal epithelial cells - Unknown function" Microtubules "HPA040234: AB_10805709" "unprognostic (2.68e-1)" "unprognostic (1.21e-2)" "unprognostic (2.35e-1)" "unprognostic (1.47e-1)" "prognostic unfavorable (5.15e-4)" "unprognostic (1.01e-1)" "prognostic unfavorable (7.42e-7)" "unprognostic (1.53e-1)" "unprognostic (2.90e-2)" "unprognostic (2.38e-2)" "unprognostic (2.13e-2)" "unprognostic (2.91e-1)" "prognostic unfavorable (1.36e-10)" "unprognostic (3.85e-2)" "unprognostic (2.70e-1)" "unprognostic (1.00e-1)" "unprognostic (1.93e-1)" 23.4 8.1 26.0 27.4 24.6 113.9 17.0 25.7 29.0 12.9 16.9 14.6 12.9 13.6 4.6 24.3 11.3 14.8 15.0 25.4 30.0 8.8 18.6 16.2 22.1 29.1 28.7 9.6 10.5 8.6 11.7 23.3 33.5 11.4 15.0 19.3 16.9 9.1 10.8 18.5 13.9 18.4 22.2 31.3 12.4 7.4 28.5 14.7 15.3 16.1 20.9 22.7 14.4 25.1 45.3 19.8 31.5 21.8 25.6 17.8 30.9 26.7 31.5 45.9 33.9 18.3 28.4 20.9 16.7 35.5 24.0 31.3 33.8 15.9 39.2 132.6 28.7 20.3 15.3 25.7 22.0 18.1 16.9 15.5 21.3 42.3 27.9 16.5 25.9 31.6 21.4 41.8 18.4 22.1 34.5 14.6 30.4 28.1 18.8 28.3 27.2 22.2 19.2 11.3 14.6 17.7 17.9 13.4 19.3 23.9 12.1 17.6 22.2 31.5 24.2 52.3 31.0 49.7 38.8 18.1 17.9 32.5 21.9 0.0 0.5 10.0 1.6 1.1 1.1 0.4 1.2 1.2 0.8 0.3 0.7 0.8 48.8 1.0 0.8 0.4 2.7 0.5 26.0 24.6 25.7 29.0 25.4 30.0 29.1 28.7 33.5 22.2 28.5 25.1 12.9 9.6 7.9 6.5 7.5 25.6 8.6 4.4 6.8 39.8 8.4 6.6 6.0 10.0 6.8 1.8 27.1 10.6 21.2 27.0 0.0 4.1 3.8 6.1 7.0 9.1 3.0 9.3 10.2 2.8 7.1 7.1 4.6 12.7 1.3 5.9 7.9 12.0 7.3 18.5 10.2 3.9 2.0 8.5 17.0 2.1 6.2 11.0 10.6 5.6 26.6 5.7 12.3 4.0 6.3 8.0 25.6 3.8 8.3 19.3 10.4 2.2 4.6 35.3 0.0 7.1 6.2 3.5 11.4 14.6 36.2 6.2 17.4 8.0 7.0 34.7 ZDHHC19 MGC33345 ENSG00000163958 "Zinc finger DHHC-type palmitoyltransferase 19" Q8WVZ1 3 196197452-196211437 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 32 "testis: 50.1" "Group enriched" "Detected in some" 17 "Early spermatids: 332.1;Late spermatids: 810.2" "Low cancer specificity" "Detected in some" "Not detected" "Not detected" "Group enriched" "Detected in some" 19 "eosinophil: 1.2;memory B-cell: 2.5;naive B-cell: 2.4;neutrophil: 1.5" "Group enriched" "Detected in many" 20 "B-cells: 2.5;granulocytes: 1.5" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" NA NA "Cluster 37: B-cells - Transcription" "Cluster 74: Testis - Spermatogenesis" "Cluster 25: Spermatids - Spermatogenesis" "unprognostic (1.15e-1)" "unprognostic (7.50e-4)" "unprognostic (2.87e-3)" "unprognostic (6.72e-3)" "unprognostic (3.79e-1)" "unprognostic (1.59e-1)" "unprognostic (2.05e-2)" "unprognostic (1.25e-1)" "unprognostic (3.66e-3)" "unprognostic (4.63e-2)" "unprognostic (6.52e-2)" "unprognostic (2.86e-2)" "unprognostic (3.46e-7)" "unprognostic (8.05e-4)" "unprognostic (4.71e-1)" "unprognostic (7.08e-3)" "unprognostic (4.28e-2)" 0.1 0.8 0.1 0.3 0.1 0.2 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.6 0.3 0.0 0.1 0.1 0.3 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 1.5 0.0 50.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 2.5 0.0 0.0 0.0 2.4 0.0 0.0 1.5 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.2 0.3 0.1 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.0 0.3 5.3 0.3 0.1 0.0 0.0 0.2 0.0 0.4 0.4 1.5 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 332.1 0.1 0.1 0.6 0.0 0.0 0.9 0.0 0.5 0.5 0.0 0.1 0.0 9.7 0.0 3.6 1.4 0.0 0.8 0.0 0.0 1.0 0.4 810.2 16.4 1.2 0.0 2.8 0.1 0.3 0.0 0.5 0.1 0.0 0.0 32.0 0.0 0.0 0.1 0.8 0.8 0.1 0.0 0.0 0.8 5.5 3.3 0.0 0.0 2.5 0.3 6.5 0.0 0.0 ZDHHC2 "DHHC2, ZNF372" ENSG00000104219 "Zinc finger DHHC-type palmitoyltransferase 2" Q9UIJ5 8 17156482-17224799 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in all" "retina: 77.8" "Cell type enhanced" "Detected in many" "Rod photoreceptor cells: 90.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA023331, HPA023334" Uncertain Approved "Plasma membrane" NA NA "Cluster 33: Neutrophils - Chromatin organization" "Cluster 77: Retina - Visual perception" "Cluster 2: Karpas-707 - Immune response" "Cluster 46: Photoreceptor cells - Phototransduction" "Plasma membrane" "HPA023331: AB_2671165, HPA023334: " "unprognostic (8.92e-2)" "unprognostic (4.23e-1)" "unprognostic (1.80e-2)" "unprognostic (2.53e-1)" "unprognostic (6.89e-2)" "unprognostic (2.25e-1)" "unprognostic (6.12e-2)" "unprognostic (1.78e-2)" "unprognostic (1.04e-1)" "unprognostic (2.37e-2)" "unprognostic (2.16e-1)" "unprognostic (1.58e-1)" "prognostic favorable (3.24e-4)" "unprognostic (5.00e-2)" "unprognostic (3.87e-1)" "unprognostic (2.87e-2)" "unprognostic (5.10e-2)" 10.3 24.4 10.3 11.0 8.9 31.7 7.5 43.9 14.8 13.4 13.5 15.3 10.5 7.6 11.8 3.9 13.8 7.0 9.7 8.0 22.4 26.4 6.5 14.3 9.3 17.7 13.6 11.8 30.7 28.9 9.5 6.9 16.6 11.7 11.2 77.8 19.6 12.9 17.9 1.8 10.3 9.5 13.5 10.7 16.3 16.6 26.3 12.7 33.5 37.2 11.7 19.7 4.4 22.0 2.3 12.4 23.7 4.9 20.3 36.0 13.8 41.5 49.9 23.0 27.2 3.9 34.3 26.1 15.9 36.2 57.9 1.5 32.2 20.5 42.5 16.8 16.2 23.2 16.8 5.0 20.3 24.7 2.6 15.3 3.2 28.8 26.1 52.7 38.4 29.8 2.7 66.5 28.1 0.6 18.3 15.2 15.0 18.8 19.1 17.9 23.7 9.5 41.8 26.7 12.7 8.3 17.8 0.0 3.8 34.9 1.0 10.9 32.0 11.6 35.2 26.0 41.7 13.2 53.7 30.1 32.1 22.2 5.3 1.6 1.2 2.6 1.9 1.3 3.3 2.5 2.4 2.3 1.1 2.1 2.1 2.3 0.9 2.2 0.8 2.3 1.3 0.7 10.3 8.9 43.9 14.8 8.0 22.4 17.7 13.6 16.6 13.5 26.3 22.0 20.9 44.8 25.4 34.0 18.8 3.1 15.3 4.1 1.8 54.4 21.1 8.0 15.2 15.7 10.5 51.5 77.2 0.5 27.1 8.7 21.5 22.2 8.3 19.3 6.8 11.6 19.7 22.7 49.8 33.4 1.2 10.4 9.7 25.4 8.2 10.9 10.0 8.0 12.6 11.8 20.1 16.2 6.1 28.6 16.1 11.7 5.0 22.2 23.2 37.5 12.9 40.6 8.2 26.7 61.3 37.0 10.7 3.0 14.0 31.3 6.1 26.1 7.7 90.2 13.1 9.1 7.5 6.6 3.9 3.3 2.7 0.4 17.0 8.7 17.0 36.5 ZDHHC20 "DHHC20, FLJ25952" ENSG00000180776 "Zinc finger DHHC-type palmitoyltransferase 20" Q5W0Z9 13 21372571-21459370 "Enzymes, Metabolic proteins, Predicted membrane proteins, Transporters" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enhanced" "Detected in many" "brain: 95.0" "Cell type enriched" "Detected in many" 4 "Oligodendrocytes: 434.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA014483, HPA014702" Approved Supported "Vesicles,Plasma membrane" NA NA "Cluster 25: Monocytes - Inflammatory response" "Cluster 70: Brain - Nervous system development" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 42: Oligodendrocytes - Myelin sheath organization" "Vesicles, Plasma membrane" "HPA014483: AB_1859000, HPA014702: AB_1859001" "unprognostic (1.31e-1)" "unprognostic (2.16e-3)" "unprognostic (7.31e-3)" "unprognostic (8.89e-2)" "unprognostic (3.37e-2)" "unprognostic (1.03e-1)" "unprognostic (1.06e-3)" "unprognostic (3.77e-1)" "unprognostic (1.24e-2)" "unprognostic (1.26e-2)" "prognostic unfavorable (6.55e-4)" "unprognostic (1.10e-1)" "prognostic unfavorable (1.01e-4)" "unprognostic (3.76e-2)" "unprognostic (7.65e-2)" "unprognostic (6.15e-2)" "unprognostic (1.13e-2)" 10.9 9.2 15.2 17.6 52.9 30.0 11.5 51.8 23.3 16.2 0.0 16.9 19.3 13.8 9.6 30.2 10.9 17.1 7.9 12.0 27.0 6.7 9.8 17.0 18.0 70.8 40.7 9.7 9.0 8.9 4.4 18.8 60.3 15.1 16.1 5.6 8.5 12.2 4.0 22.1 19.0 15.2 35.1 16.1 39.5 31.7 40.7 22.6 16.4 9.4 19.5 22.9 9.3 95.0 32.9 16.4 27.7 18.1 24.5 26.7 68.3 35.6 36.3 23.3 20.6 33.8 102.5 34.8 19.3 44.7 23.8 52.7 30.5 26.5 44.8 40.0 20.4 61.8 11.7 19.6 14.1 43.3 25.8 24.2 19.4 23.6 16.2 30.0 37.6 45.9 17.3 14.9 35.3 27.2 62.0 17.2 22.9 87.3 18.0 49.8 49.1 12.7 28.9 59.7 25.2 11.4 46.0 28.7 19.3 28.6 27.0 21.8 62.6 25.0 24.0 41.7 27.4 15.6 19.9 37.7 18.2 23.6 73.1 12.6 16.2 3.8 10.1 14.9 9.3 4.6 8.7 8.7 8.4 3.4 8.1 8.4 3.0 11.2 13.8 4.1 10.4 13.5 15.2 52.9 51.8 23.3 12.0 27.0 70.8 40.7 60.3 35.1 40.7 95.0 27.6 51.3 31.5 29.0 19.9 1.0 7.8 1.4 18.2 7.4 21.9 13.7 7.4 14.3 20.7 11.0 8.4 20.7 34.7 35.5 0.0 8.5 91.3 23.4 25.2 25.7 24.0 8.4 69.1 12.2 20.9 13.6 53.0 34.5 14.0 16.1 20.0 20.8 21.7 18.5 80.0 29.1 2.0 92.5 3.2 81.2 15.5 49.0 1.8 46.9 48.4 3.7 30.9 54.8 434.3 22.8 25.5 10.9 18.1 14.5 30.3 6.3 11.7 9.5 19.7 12.7 11.6 10.4 14.1 28.1 1.6 44.6 28.4 9.7 25.1 25.6 ZDHHC21 "DHHC21, DNZ1, HSPC097" ENSG00000175893 "Zinc finger DHHC-type palmitoyltransferase 21" Q8IVQ6 9 14611071-14693432 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in all" "Excitatory neurons: 219.4;Inhibitory neurons: 201.6;Oligodendrocyte precursor cells: 268.9;Oligodendrocytes: 158.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Cell line enhanced" "Detected in many" "HEL: 29.9" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA065254 Approved Approved "Golgi apparatus,Cytosol" NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 69: Cerebellum - Gene expression regulation" "Cluster 36: HEL - Hemostasis" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" "Golgi apparatus, Cytosol" "HPA065254: AB_2685446" "unprognostic (2.95e-2)" "unprognostic (1.45e-1)" "unprognostic (2.06e-2)" "unprognostic (2.01e-1)" "unprognostic (4.19e-2)" "unprognostic (2.58e-2)" "unprognostic (2.81e-2)" "unprognostic (1.13e-2)" "unprognostic (2.18e-2)" "unprognostic (8.37e-2)" "unprognostic (9.79e-3)" "unprognostic (3.97e-2)" "prognostic favorable (1.29e-4)" "unprognostic (1.21e-1)" "unprognostic (1.14e-1)" "unprognostic (8.87e-2)" "prognostic favorable (9.28e-6)" 3.7 5.7 4.7 4.6 5.8 2.5 6.2 12.7 6.7 6.2 2.2 4.7 6.8 4.9 6.1 8.5 4.5 3.5 5.1 6.0 4.5 4.9 2.6 5.2 6.6 3.4 3.3 5.2 4.7 4.8 6.5 4.2 3.7 5.2 5.2 10.6 4.6 3.7 4.5 8.7 7.2 4.1 3.4 5.5 4.3 4.1 3.5 2.6 6.1 3.4 6.1 4.2 6.7 4.7 7.1 3.6 6.9 4.6 1.1 1.2 5.3 8.9 2.7 3.1 3.5 1.8 3.3 7.0 2.1 6.2 3.9 4.5 4.8 2.9 4.4 14.1 3.7 29.9 8.3 3.5 3.6 5.3 9.5 2.3 6.6 3.6 2.3 5.7 18.4 2.8 2.5 0.8 5.5 3.9 1.2 5.1 4.8 3.0 6.7 0.0 3.3 3.5 9.6 7.8 4.2 11.3 4.1 5.0 2.8 5.3 6.3 8.6 13.2 2.2 3.3 2.2 8.3 2.8 5.6 0.0 4.6 0.3 2.3 0.2 0.1 0.0 0.4 0.3 0.4 2.0 0.4 0.4 0.0 1.4 0.3 0.4 0.0 1.1 0.2 0.5 0.6 0.2 4.7 5.8 12.7 6.7 6.0 4.5 3.4 3.3 3.7 3.4 3.5 4.7 18.0 22.4 24.1 132.9 46.6 9.6 9.3 8.1 13.1 45.1 23.0 14.1 23.2 24.3 18.2 44.1 43.8 8.8 27.7 31.9 5.9 16.0 5.3 18.1 23.5 18.4 15.6 7.2 219.4 17.9 7.1 14.0 26.5 24.6 10.8 36.7 32.9 10.1 11.1 37.0 201.6 14.6 10.2 15.5 8.2 7.7 19.3 11.8 1.8 107.7 17.7 65.7 41.2 268.9 158.2 35.9 14.1 31.2 20.8 12.4 46.7 11.3 12.7 49.4 6.6 19.7 15.3 22.3 26.6 24.4 20.0 7.7 14.4 10.5 13.9 16.1 ZDHHC22 C14orf59 ENSG00000177108 "Zinc finger DHHC-type palmitoyltransferase 22" Q8N966 14 77131270-77142734 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in some" 7 "brain: 51.3" "Cell type enhanced" "Detected in some" "Bipolar cells: 17.3;Excitatory neurons: 8.8;Inhibitory neurons: 13.4;Late spermatids: 5.0;Oligodendrocyte precursor cells: 24.6" "Cancer enriched" "Detected in single" 40 "glioma: 7.7" "Low region specificity" "Detected in many" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Group enriched" "Detected in some" 4 "AF22: 3.6;NTERA-2: 3.8;RH-30: 6.4;SCLC-21H: 7.0" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA049471, HPA072213" Enhanced "Plasma membrane" NA NA "Cluster 6: Brain - Smell perception" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 56: Bipolar cells - Visual perception" "Plasma membrane" "HPA049471: AB_2732553, HPA072213: AB_2686496" "unprognostic (1.02e-1)" "unprognostic (3.42e-1)" "unprognostic (1.22e-4)" "unprognostic (1.66e-1)" "unprognostic (8.86e-2)" "unprognostic (2.68e-1)" "unprognostic (3.41e-1)" "unprognostic (1.87e-1)" "unprognostic (6.94e-4)" "unprognostic (3.05e-1)" "unprognostic (6.30e-2)" "unprognostic (1.16e-1)" "unprognostic (4.02e-1)" "unprognostic (1.95e-1)" "unprognostic (4.79e-1)" 0.0 0.2 14.9 0.0 15.3 0.0 0.0 25.9 33.8 0.1 0.0 0.7 0.0 0.0 0.2 0.1 0.0 0.0 0.0 21.2 12.8 0.0 0.0 0.0 0.0 1.2 22.7 0.0 0.0 0.0 4.7 0.0 1.0 0.0 0.1 7.2 0.0 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.2 0.5 51.3 0.0 0.1 0.4 0.0 0.1 0.0 13.9 0.0 0.0 3.6 0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.5 0.0 0.0 3.8 0.0 0.5 0.0 6.4 0.0 0.0 0.0 7.0 1.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 14.9 15.3 25.9 33.8 21.2 12.8 1.2 22.7 1.0 0.0 51.3 13.9 0.0 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 17.3 0.0 0.0 0.3 0.0 0.0 0.0 4.2 0.0 0.0 0.0 0.0 0.0 1.4 0.0 0.0 0.3 0.0 0.0 8.8 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 13.4 0.0 0.0 0.0 0.0 5.0 0.0 0.0 0.0 1.9 0.0 0.1 0.0 24.6 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 1.5 0.0 0.0 0.0 0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ZDHHC23 MGC42530 ENSG00000184307 "Zinc finger DHHC-type palmitoyltransferase 23" Q8IYP9 3 113947901-113965401 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enhanced" "Detected in many" "Early spermatids: 26.7;Excitatory neurons: 72.2;Late spermatids: 41.0" "Low cancer specificity" "Detected in all" "Group enriched" "Detected in many" 9 "amygdala: 5.4;basal ganglia: 7.3;cerebral cortex: 9.4;hippocampal formation: 7.4" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016808 Uncertain Approved Nucleoplasm NA NA "Cluster 43: B-cells - Humoral immune response" "Cluster 45: Intestine - Brush border" "Cluster 7: SCLC-21H - Neuronal signaling" "Cluster 21: Neurons & Oligodendrocytes - Neuronal signaling" Nucleoplasm "HPA016808: AB_1859002" "unprognostic (2.10e-3)" "unprognostic (2.86e-1)" "unprognostic (4.48e-3)" "prognostic unfavorable (2.85e-4)" "unprognostic (1.49e-1)" "unprognostic (3.98e-3)" "unprognostic (1.37e-2)" "unprognostic (2.48e-1)" "unprognostic (3.19e-1)" "unprognostic (6.63e-2)" "unprognostic (1.86e-1)" "unprognostic (2.78e-2)" "prognostic favorable (1.48e-7)" "unprognostic (2.58e-2)" "unprognostic (1.83e-1)" "prognostic unfavorable (5.90e-4)" "unprognostic (3.29e-3)" 1.1 1.0 5.4 3.0 7.3 1.2 2.6 0.0 9.4 1.4 13.2 9.4 7.3 1.2 1.5 1.5 2.4 1.6 1.0 7.4 0.0 5.5 4.0 3.2 2.8 0.0 0.0 0.9 4.8 7.4 3.2 0.9 0.0 2.5 11.5 3.6 6.6 1.8 1.2 3.8 6.8 1.3 0.0 2.4 6.2 12.2 0.0 1.2 6.1 0.9 3.8 1.9 1.5 0.8 17.8 4.4 0.5 10.1 1.5 0.3 14.8 6.9 2.1 1.3 2.0 7.1 11.6 8.1 5.9 4.0 11.0 11.4 13.0 1.9 2.2 4.9 6.0 7.5 7.0 4.4 0.5 8.5 6.7 0.3 2.2 0.3 0.8 1.6 1.1 8.5 0.0 4.6 0.2 10.2 7.0 0.5 3.1 18.2 4.9 1.2 5.8 6.8 7.0 8.6 17.6 4.4 5.3 17.5 3.3 3.9 10.5 2.7 0.3 4.8 9.6 1.0 3.1 5.2 7.3 13.2 4.1 5.4 2.0 0.0 0.0 0.0 0.0 0.0 0.0 0.5 0.1 0.0 0.0 0.3 0.0 0.0 0.1 0.0 0.0 0.2 0.0 0.0 5.4 7.3 0.0 9.4 7.4 0.0 0.0 0.0 0.0 0.0 0.0 0.8 3.3 0.0 1.5 12.1 10.5 3.1 2.0 2.3 0.6 2.1 4.8 4.2 1.4 7.2 2.2 16.5 8.4 0.9 2.7 21.8 0.0 2.1 26.7 13.6 1.6 2.8 13.8 0.4 72.2 1.9 1.6 1.0 9.2 8.5 0.0 3.2 4.2 6.4 0.4 0.0 4.0 12.7 0.0 0.3 2.2 41.0 1.2 1.3 3.6 2.8 1.0 4.2 0.0 2.5 5.4 0.7 8.3 0.0 2.3 3.9 10.9 4.4 8.7 0.9 0.0 1.7 0.7 18.2 2.9 2.1 2.7 0.3 1.3 0.9 12.6 1.7 ZDHHC24 ENSG00000174165 "Zinc finger DHHC-type containing 24" Q6UX98 11 66520637-66546235 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" HPA016619 Approved Approved Vesicles,Cytosol NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 32: Brain & Lymphoid tissue - Unknown function" "Cluster 19: HEK293 & PC-3 - Transcription regulation" "Cluster 4: Macrophages - Innate immune response" "Vesicles, Cytosol" "HPA016619: AB_2288672" "unprognostic (2.77e-1)" "unprognostic (2.51e-1)" "unprognostic (2.52e-1)" "unprognostic (1.55e-3)" "prognostic unfavorable (3.28e-4)" "unprognostic (8.76e-2)" "unprognostic (7.74e-3)" "unprognostic (7.11e-2)" "unprognostic (6.20e-2)" "unprognostic (1.41e-1)" "unprognostic (3.73e-2)" "unprognostic (1.48e-1)" "unprognostic (8.10e-2)" "unprognostic (6.99e-3)" "unprognostic (3.10e-1)" "unprognostic (4.88e-1)" "unprognostic (1.35e-1)" 5.2 6.9 5.8 3.3 4.5 5.0 4.7 4.2 5.4 3.6 5.8 3.5 2.8 4.3 5.1 4.3 3.9 2.2 3.6 4.9 5.2 6.2 4.6 4.5 4.3 5.5 5.2 2.7 7.1 6.0 4.7 2.5 4.8 4.5 2.1 2.6 5.0 2.7 2.9 5.1 4.7 1.9 4.4 7.2 4.8 3.7 6.4 3.1 5.9 1.1 3.0 4.0 3.4 4.5 5.2 7.4 2.4 6.5 5.8 4.7 6.2 3.9 3.4 3.1 2.1 6.5 7.7 1.6 11.5 3.3 8.3 11.9 1.9 3.4 2.1 7.6 4.9 2.9 3.7 4.1 5.5 3.4 6.9 5.6 6.2 2.5 3.6 3.7 5.1 13.0 4.2 4.3 4.0 10.4 7.4 8.6 5.3 12.2 7.6 8.8 5.3 9.3 3.9 3.6 3.5 5.6 6.7 6.5 11.6 2.7 9.5 2.4 8.0 7.1 2.4 8.3 3.1 6.9 2.2 2.1 6.2 1.5 8.2 3.0 5.9 1.0 7.3 5.7 6.6 6.4 6.0 8.4 7.2 7.5 3.8 5.9 2.2 8.0 5.0 23.1 6.6 6.1 5.8 4.5 4.2 5.4 4.9 5.2 5.5 5.2 4.8 4.4 6.4 4.5 21.7 12.8 8.3 7.8 21.9 8.0 15.2 26.8 10.8 9.6 21.5 15.2 4.5 22.8 17.3 23.9 10.4 33.0 49.9 29.0 9.8 50.3 13.5 15.1 14.4 23.3 14.4 6.3 7.6 49.4 37.2 15.0 17.9 19.8 8.9 18.5 23.2 14.9 63.9 23.5 7.0 17.8 20.3 42.8 14.8 12.1 7.5 27.9 17.8 5.6 36.4 16.9 46.4 4.0 8.5 42.8 40.6 9.8 15.8 24.9 54.8 35.2 14.7 10.3 19.7 11.2 15.1 29.6 4.1 21.6 8.1 24.1 23.3 18.5 21.8 23.1 ZDHHC3 "DHHC3, GODZ, ZNF373" ENSG00000163812 "Zinc finger DHHC-type palmitoyltransferase 3" Q9NYG2 3 44915257-44976185 "Enzymes, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Group enriched" "Detected in all" 8 "Early spermatids: 570.7;Late spermatids: 1564.3" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "CAB012465, HPA016616" Approved Approved "Golgi apparatus" NA NA "Cluster 38: Basophils - Unknown function" "Cluster 37: Intestine - Unknown function" "Cluster 32: U-937 - Innate immune response" "Cluster 31: Spermatids - Spermatogenesis" "Golgi apparatus" "CAB012465: , HPA016616: AB_1859004" "unprognostic (2.80e-1)" "unprognostic (6.07e-2)" "prognostic favorable (3.43e-4)" "unprognostic (3.10e-2)" "unprognostic (2.47e-2)" "unprognostic (3.38e-1)" "prognostic unfavorable (1.37e-4)" "unprognostic (4.20e-2)" "unprognostic (1.04e-1)" "unprognostic (6.37e-2)" "unprognostic (1.22e-3)" "unprognostic (1.24e-1)" "prognostic favorable (1.81e-8)" "unprognostic (2.64e-1)" "unprognostic (1.49e-1)" "unprognostic (5.33e-2)" "unprognostic (4.26e-2)" 50.1 48.6 23.0 25.7 21.5 82.8 36.3 27.9 22.9 42.2 25.8 70.6 44.1 35.4 24.5 58.0 27.5 32.0 36.3 25.8 21.1 40.3 32.3 41.9 21.9 28.7 25.1 28.9 22.2 46.0 13.4 28.7 29.8 35.6 64.6 16.6 33.3 40.1 43.7 70.0 58.1 36.3 25.8 29.6 55.3 80.8 27.0 26.9 38.6 52.8 33.3 53.6 42.5 25.3 62.5 53.3 41.0 49.1 219.2 100.5 46.8 58.8 80.7 78.3 66.5 61.0 85.1 58.7 31.4 107.9 52.8 80.7 68.4 104.3 74.6 61.7 29.3 55.9 57.9 45.7 50.6 136.3 43.0 92.5 111.6 73.6 67.2 59.8 79.6 63.8 73.8 51.3 78.1 42.9 46.2 73.6 60.7 155.9 96.7 29.9 40.6 47.0 66.7 176.7 14.6 52.8 70.3 70.5 36.4 70.4 57.4 88.2 78.0 55.4 55.2 60.2 66.3 32.2 66.6 59.6 55.2 198.9 39.4 53.7 24.5 32.6 14.6 12.3 13.3 10.7 11.0 16.1 26.8 12.6 10.2 14.4 25.4 14.5 17.5 15.3 17.1 13.6 23.0 21.5 27.9 22.9 25.8 21.1 28.7 25.1 29.8 25.8 27.0 25.3 41.5 41.7 82.1 7.5 17.8 48.2 42.1 40.8 48.9 9.8 24.4 20.8 29.2 24.3 27.1 53.3 6.2 47.7 23.4 105.6 72.4 46.6 570.7 18.8 31.2 34.1 35.9 68.8 15.7 79.0 59.4 26.4 69.3 26.6 19.0 21.5 35.7 29.4 49.5 15.2 15.6 78.2 38.7 34.0 26.7 1564.3 51.9 37.4 24.9 18.7 35.6 25.1 34.0 15.1 11.2 115.8 73.1 44.8 26.2 73.7 112.9 30.1 20.9 10.6 19.7 15.6 31.9 104.5 45.3 70.5 60.2 101.7 25.0 26.1 72.8 128.9 ZDHHC4 "FLJ10479, ZNF374" ENSG00000136247 "Zinc finger DHHC-type palmitoyltransferase 4" Q9NPG8 7 6577434-6589374 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA032124 Approved NA NA "Cluster 3: Plasmacytoid DCs - Unknown function" "Cluster 8: Non-specific - Mitochondria" "Cluster 26: Non-specific - Cell cycle regulation" "Cluster 39: Non-specific - Basic cellular processes" "HPA032124: AB_10610699" "unprognostic (1.07e-1)" "prognostic unfavorable (9.35e-4)" "unprognostic (6.82e-2)" "unprognostic (8.36e-2)" "unprognostic (3.66e-1)" "prognostic unfavorable (3.95e-6)" "unprognostic (9.80e-2)" "unprognostic (1.40e-1)" "unprognostic (2.37e-1)" "unprognostic (4.60e-2)" "unprognostic (1.52e-1)" "unprognostic (1.43e-1)" "prognostic favorable (1.18e-7)" "unprognostic (8.75e-2)" "unprognostic (9.41e-2)" "unprognostic (1.42e-1)" "prognostic unfavorable (8.94e-4)" 25.9 31.0 17.5 16.2 19.4 18.8 24.3 19.4 18.8 24.4 21.1 38.2 19.1 28.0 34.2 19.5 31.0 23.3 26.5 17.8 21.1 33.6 35.7 21.9 20.6 19.5 20.9 27.6 37.9 33.0 23.9 18.5 20.5 25.3 20.8 19.3 32.2 25.5 54.5 13.5 22.5 24.6 19.1 17.9 32.9 33.8 20.9 18.6 36.8 43.7 19.4 29.2 18.7 19.6 50.7 35.0 11.7 68.8 60.8 41.4 52.4 26.2 6.5 31.2 44.3 44.3 69.7 29.9 40.1 51.3 66.2 44.2 40.8 25.7 33.2 16.8 24.0 31.4 37.8 48.6 47.8 39.8 36.6 45.2 37.6 24.1 0.0 40.8 27.9 51.8 72.4 40.3 43.5 59.2 22.1 39.6 59.4 45.0 28.1 29.4 57.5 40.3 25.9 43.7 26.9 68.7 35.5 11.8 51.7 60.4 43.1 45.8 18.7 40.6 54.9 39.2 39.3 62.1 58.7 66.7 21.6 50.0 56.5 56.3 25.0 44.8 24.1 31.9 24.8 38.8 25.1 27.3 28.1 36.0 31.4 31.1 2.9 28.7 26.5 113.9 24.5 29.3 17.5 19.4 19.4 18.8 17.8 21.1 19.5 20.9 20.5 19.1 20.9 19.6 11.7 38.5 20.1 2.9 23.3 11.3 46.5 63.4 24.5 30.2 42.1 34.7 4.4 57.2 42.4 35.0 10.4 69.0 46.1 12.1 86.1 60.5 3.0 24.1 22.1 14.3 32.4 26.5 4.6 66.4 69.4 26.0 20.9 20.3 10.2 25.9 25.0 47.3 55.3 21.9 5.4 21.2 42.7 36.5 18.2 3.5 18.0 24.8 21.4 2.8 35.3 71.8 28.8 5.0 6.7 54.6 21.4 32.7 34.2 39.5 27.2 71.9 32.5 24.6 13.1 20.9 25.6 70.2 69.7 19.2 9.2 48.8 19.0 40.6 27.5 39.5 ZDHHC5 "DHHC5, KIAA1748, ZNF375" ENSG00000156599 "Zinc finger DHHC-type palmitoyltransferase 5" Q9C0B5 11 57667747-57701182 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA014670 Approved Approved "Nucleoplasm,Plasma membrane" NA NA "Cluster 5: Granulocytes - Unknown function" "Cluster 23: Testis - Cell cycle regulation" "Cluster 15: RT4 - Unknown function" "Cluster 46: Photoreceptor cells - Phototransduction" "Plasma membrane" Nucleoplasm "HPA014670: AB_2257442" "unprognostic (1.34e-1)" "unprognostic (3.47e-2)" "unprognostic (2.51e-1)" "unprognostic (2.29e-1)" "unprognostic (5.32e-2)" "unprognostic (1.70e-2)" "unprognostic (9.82e-3)" "unprognostic (1.74e-3)" "unprognostic (4.36e-2)" "unprognostic (9.78e-2)" "prognostic unfavorable (6.74e-5)" "unprognostic (1.76e-1)" "unprognostic (4.72e-3)" "unprognostic (2.16e-1)" "unprognostic (6.80e-2)" "unprognostic (2.06e-2)" "unprognostic (1.74e-3)" 29.0 21.7 8.3 27.2 7.8 29.2 25.8 8.3 9.5 27.0 11.0 36.4 29.6 22.3 24.1 60.9 25.0 27.9 27.9 7.5 9.2 28.2 36.7 29.0 24.4 8.5 8.9 20.7 31.6 45.3 12.6 36.7 8.7 28.0 34.4 35.9 35.0 26.7 40.9 45.2 31.0 29.0 6.9 25.5 30.2 36.2 10.9 30.6 36.9 45.5 35.0 42.3 28.7 8.9 80.3 86.2 33.7 34.7 74.9 57.4 64.9 72.8 89.8 61.8 46.3 52.3 97.0 53.4 91.9 89.5 53.1 110.1 53.6 88.9 55.4 66.5 24.4 45.8 40.1 49.3 81.5 85.9 73.7 81.3 79.3 88.8 92.9 51.1 71.0 45.6 61.5 66.2 79.7 48.4 49.1 29.3 41.1 61.0 52.2 47.8 66.6 67.1 74.8 115.2 25.3 30.7 67.6 77.0 78.5 45.4 81.9 52.6 80.7 76.5 40.7 82.9 52.2 48.2 63.0 45.9 59.1 44.4 68.0 11.6 5.2 7.1 6.9 6.8 8.3 5.8 6.7 6.0 5.4 5.7 6.7 6.9 6.9 5.0 8.1 9.0 7.0 6.8 8.3 7.8 8.3 9.5 7.5 9.2 8.5 8.9 8.7 6.9 10.9 8.9 28.8 16.0 10.5 14.7 13.4 16.2 12.7 13.7 16.5 21.4 20.4 15.2 21.6 12.8 19.8 12.9 37.5 10.1 20.3 41.3 3.9 14.4 21.3 19.9 22.1 17.1 11.5 10.8 16.4 18.2 9.9 15.5 15.8 35.5 19.7 24.9 16.1 15.1 13.0 13.5 17.9 17.5 18.3 16.3 10.2 9.8 11.8 18.4 1.8 14.0 16.0 14.0 17.5 17.6 14.7 26.0 20.8 7.5 12.4 15.1 22.9 11.4 17.4 47.7 0.0 18.4 18.5 13.3 7.1 31.5 19.9 18.6 15.9 16.8 19.7 20.5 ZDHHC6 "FLJ21952, ZNF376" ENSG00000023041 "Zinc finger DHHC-type palmitoyltransferase 6" Q9H6R6 10 112424428-112446917 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in all" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA014357 Approved NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 32: U-937 - Innate immune response" "Cluster 29: Early spermatids - Spermatogenesis" "HPA014357: AB_2304658" "unprognostic (1.21e-1)" "unprognostic (1.00e-1)" "unprognostic (6.31e-2)" "unprognostic (2.51e-2)" "unprognostic (1.80e-1)" "unprognostic (2.07e-1)" "unprognostic (3.29e-2)" "unprognostic (6.24e-2)" "unprognostic (5.21e-1)" "unprognostic (3.54e-2)" "unprognostic (1.56e-1)" "unprognostic (7.14e-3)" "unprognostic (3.00e-2)" "unprognostic (9.30e-2)" "unprognostic (8.87e-2)" "unprognostic (7.64e-2)" "unprognostic (1.22e-2)" 19.5 19.9 15.2 24.6 16.0 21.8 22.7 16.7 18.9 21.2 20.2 24.5 44.6 24.0 33.2 23.7 19.3 23.2 17.0 15.4 16.1 59.3 29.5 20.0 30.6 15.5 15.7 25.7 21.3 21.4 15.4 25.9 15.6 22.4 29.9 21.3 23.9 20.6 14.9 20.5 45.8 17.8 15.9 24.8 25.9 13.6 16.9 25.0 26.2 18.1 30.6 23.9 20.8 17.9 51.7 39.4 40.3 50.2 38.2 28.8 28.5 49.3 46.7 38.2 45.3 37.7 89.6 28.4 22.1 30.2 43.0 60.0 33.8 31.5 44.3 67.0 41.4 29.4 46.4 47.3 24.7 67.9 49.5 21.9 20.7 41.9 48.9 58.7 48.6 42.0 32.4 46.1 41.7 43.3 38.1 75.6 23.6 57.0 32.1 31.4 51.1 26.6 45.3 28.1 15.0 20.9 25.5 40.1 49.1 31.4 22.4 49.2 34.8 43.7 27.6 29.5 47.3 25.7 31.7 37.5 38.7 118.0 29.0 10.4 17.4 21.6 14.7 16.2 18.9 16.7 16.7 18.5 16.6 14.0 14.1 15.9 11.3 16.0 13.7 13.6 23.9 15.9 15.2 16.0 16.7 18.9 15.4 16.1 15.5 15.7 15.6 15.9 16.9 17.9 21.0 22.4 20.1 11.8 35.9 20.3 31.9 23.2 23.9 11.0 21.9 16.1 14.3 31.5 27.4 35.0 8.4 34.8 25.7 31.3 60.7 35.8 72.4 14.9 15.5 18.7 11.4 26.1 15.0 29.8 46.9 17.9 16.3 23.8 23.5 17.8 19.2 21.2 34.4 15.2 15.7 22.7 10.2 20.2 35.9 17.7 16.1 28.6 12.4 12.2 22.2 21.0 23.7 15.1 14.4 31.2 27.9 19.5 23.7 25.7 66.9 39.7 13.4 15.5 6.6 13.9 18.2 11.7 12.5 27.6 22.3 36.5 33.0 10.9 28.5 47.7 ZDHHC7 "DHHC7, FLJ10792, FLJ20279, SERZ-B, SERZ1, ZNF370" ENSG00000153786 "Zinc finger DHHC-type palmitoyltransferase 7" Q9NXF8 16 84974175-85011535 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in all" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA019215, HPA059054, HPA059642" Uncertain Supported "Golgi apparatus" NA NA "Cluster 52: Eosinophils - Transcription" "Cluster 59: Non-specific - Translation" "Cluster 42: Epithelial cell lines - Epithelial cell function" "Cluster 19: Monocytes & Neutrophils - Innate immune response" "Golgi apparatus" "HPA019215: AB_2670102, HPA059054: AB_2683892, HPA059642: AB_2684093" "unprognostic (9.77e-2)" "unprognostic (2.12e-1)" "unprognostic (6.70e-2)" "unprognostic (1.09e-1)" "unprognostic (2.31e-1)" "unprognostic (8.76e-2)" "prognostic unfavorable (4.20e-4)" "unprognostic (1.41e-2)" "unprognostic (5.78e-2)" "unprognostic (2.21e-2)" "unprognostic (7.79e-3)" "unprognostic (8.04e-2)" "prognostic favorable (1.12e-5)" "unprognostic (1.67e-1)" "unprognostic (1.36e-2)" "unprognostic (2.45e-1)" "unprognostic (5.42e-2)" 33.0 28.1 19.0 24.7 18.8 64.2 26.8 21.4 18.6 40.0 27.1 42.5 27.1 36.8 12.8 27.6 27.7 31.2 31.2 19.1 19.8 35.4 30.0 37.2 26.5 20.1 21.0 27.7 26.9 35.5 19.6 33.4 20.3 32.8 32.4 10.3 24.1 20.0 56.5 31.8 33.5 30.0 19.1 35.4 44.7 14.1 23.5 16.1 25.5 58.4 23.5 37.4 33.1 19.6 63.8 55.0 28.5 34.5 123.1 92.3 38.9 57.4 110.8 88.4 43.7 58.3 72.4 29.1 32.7 93.5 29.0 65.6 37.1 76.1 110.9 16.4 29.7 21.0 22.0 66.5 51.5 40.0 21.2 76.7 85.4 72.5 41.5 56.0 46.1 26.7 68.9 9.7 56.8 75.8 27.0 38.1 44.3 53.2 39.5 33.6 26.2 15.7 86.4 82.5 24.2 29.8 74.3 40.9 36.1 43.0 77.6 24.0 67.9 53.1 39.9 49.8 34.3 33.5 51.0 65.5 50.1 29.1 43.0 7.5 9.7 8.3 2.1 8.2 2.6 1.4 2.0 1.7 6.3 2.2 1.5 2.2 6.4 1.4 7.2 4.3 0.5 3.6 19.0 18.8 21.4 18.6 19.1 19.8 20.1 21.0 20.3 19.1 23.5 19.6 13.3 32.1 25.2 12.1 10.8 13.3 21.5 25.4 17.1 9.2 16.2 13.2 22.5 12.8 17.9 16.5 6.2 18.5 15.7 37.7 1.9 14.1 9.7 15.5 20.1 12.2 12.6 11.6 16.4 15.6 24.9 23.0 28.5 29.1 3.8 14.3 15.0 11.6 28.1 15.2 16.2 29.4 14.2 46.8 26.7 10.9 17.4 36.2 16.0 19.7 42.9 5.9 21.6 13.6 14.7 30.0 33.9 21.1 15.2 26.2 22.1 9.5 32.6 6.7 13.1 13.7 14.9 8.3 13.0 20.1 12.8 16.1 13.4 6.8 34.7 35.3 ZDHHC8 "KIAA1292, ZNF378" ENSG00000099904 "Zinc finger DHHC-type palmitoyltransferase 8" Q9ULC8 22 20129456-20148007 "Enzymes, Metabolic proteins, Predicted membrane proteins" "Acyltransferase, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in some" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in many" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA003422 Uncertain Approved Nucleoplasm,Cytosol NA NA "Cluster 46: Basophils - DNA binding" "Cluster 72: Non-specific - Transcription" "Cluster 1: K-562 - Erythropoiesis" "Cluster 52: Non-specific - Transcription" Cytosol Nucleoplasm "HPA003422: AB_1080640" "unprognostic (1.00e-2)" "prognostic unfavorable (9.68e-4)" "unprognostic (3.36e-1)" "unprognostic (1.36e-1)" "unprognostic (2.49e-1)" "unprognostic (8.02e-2)" "unprognostic (5.14e-2)" "unprognostic (1.03e-2)" "unprognostic (2.43e-1)" "unprognostic (1.43e-3)" "unprognostic (9.34e-3)" "unprognostic (3.20e-1)" "prognostic unfavorable (4.04e-4)" "unprognostic (1.11e-1)" "unprognostic (1.02e-1)" "unprognostic (9.88e-2)" "unprognostic (9.57e-2)" 31.6 31.2 13.8 18.6 15.1 10.7 30.4 11.3 26.4 32.6 0.0 22.8 12.1 31.2 7.5 29.3 27.7 13.0 31.6 13.9 7.0 30.4 36.1 31.0 17.1 12.2 10.0 34.6 35.6 14.4 41.3 16.9 9.9 28.1 7.0 7.4 27.6 15.4 23.6 32.2 24.7 13.1 6.6 35.7 26.4 14.9 12.3 13.7 37.3 10.3 11.7 25.3 30.9 12.8 30.0 18.7 29.3 38.7 42.0 25.0 26.3 55.1 37.3 36.6 32.6 9.8 15.2 0.1 22.3 46.0 19.8 40.2 15.5 42.2 18.0 43.2 59.4 14.5 57.2 23.0 34.5 0.0 19.5 43.7 27.9 28.2 23.6 22.5 41.4 21.0 101.4 22.8 33.0 14.7 17.8 39.1 14.9 13.2 29.4 37.8 25.6 10.9 15.6 35.9 46.9 23.7 22.4 10.7 26.6 13.1 0.7 20.4 48.0 82.5 59.8 46.8 25.0 32.6 11.5 11.7 24.2 18.7 24.8 1.3 0.4 0.1 0.8 0.5 0.4 0.2 0.2 0.4 0.1 0.5 0.4 0.5 0.0 0.4 0.2 1.3 0.7 0.2 13.8 15.1 11.3 26.4 13.9 7.0 12.2 10.0 9.9 6.6 12.3 12.8 17.4 3.2 3.1 17.6 3.7 9.1 3.8 3.6 5.7 11.9 8.2 8.1 7.1 4.3 3.5 11.0 14.6 3.6 9.2 4.3 1.9 5.2 0.5 4.3 15.7 11.5 4.2 0.8 16.6 4.5 8.5 9.3 10.2 8.7 5.7 8.7 10.4 9.8 4.9 13.5 9.9 5.9 10.2 5.0 5.0 2.1 10.8 5.7 5.4 9.4 3.7 7.4 1.0 13.0 13.3 7.7 5.4 14.7 2.7 7.6 2.7 2.1 1.5 10.8 6.6 10.5 6.8 1.4 3.8 5.5 9.8 3.4 4.2 8.0 5.0 3.4 ZDHHC9 "CGI-89, CXorf11, DHHC9, ZDHHC10, ZNF379, ZNF380" ENSG00000188706 "Zinc finger DHHC-type palmitoyltransferase 9" Q9Y397 X 129803288-129843909 "Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets, Predicted membrane proteins, Transporters" "Acyltransferase, Transferase" "Disease variant, Mental retardation" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Adipocytes: 66.0;Oligodendrocytes: 118.2" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA031814 Uncertain Supported "Endoplasmic reticulum,Golgi apparatus,Cytosol" NA NA "Cluster 27: Non-specific - Gene expression" "Cluster 45: Intestine - Brush border" "Cluster 34: Mesenchymal cell lines - ECM organization" "Cluster 50: Fibroblasts - ECM organization" "Endoplasmic reticulum, Golgi apparatus" Cytosol "HPA031814: AB_10610700" "prognostic unfavorable (9.77e-5)" "prognostic unfavorable (4.64e-5)" "unprognostic (2.83e-2)" "unprognostic (7.53e-3)" "unprognostic (2.68e-1)" "prognostic unfavorable (2.45e-4)" "unprognostic (4.01e-3)" "unprognostic (1.02e-1)" "unprognostic (4.04e-1)" "unprognostic (3.49e-2)" "unprognostic (9.70e-3)" "unprognostic (4.76e-2)" "unprognostic (1.06e-1)" "unprognostic (1.05e-2)" "unprognostic (1.31e-1)" "unprognostic (1.17e-2)" "unprognostic (4.11e-2)" 28.2 12.0 39.2 10.2 66.6 5.4 24.3 46.5 52.5 19.1 23.3 22.0 31.6 11.8 11.7 15.6 12.1 15.3 15.5 39.2 49.0 37.1 40.1 26.7 3.3 60.5 58.2 11.2 25.9 25.2 11.4 17.2 52.5 18.8 24.9 6.0 21.1 11.3 13.4 35.3 34.0 15.3 44.8 3.9 19.5 4.1 57.8 3.6 13.8 11.3 6.6 23.8 14.5 78.6 45.9 23.8 33.2 67.5 112.4 87.7 27.0 44.3 50.6 20.9 26.0 37.6 58.4 1.6 73.7 47.6 54.0 30.4 38.0 44.6 30.0 2.6 23.7 9.2 24.0 50.1 44.4 6.1 15.7 96.0 71.1 34.0 50.1 36.5 39.9 15.0 10.1 17.6 34.0 40.0 8.8 11.4 18.0 102.3 40.4 8.2 21.4 27.1 30.1 25.2 26.3 22.0 12.7 64.7 20.5 38.9 27.6 10.1 32.8 21.1 7.3 50.0 36.3 16.5 12.7 5.5 37.9 25.1 10.8 0.0 2.2 1.8 3.0 2.0 3.7 2.7 3.6 2.9 2.4 1.5 4.5 2.6 0.0 2.5 5.2 5.1 1.8 2.1 39.2 66.6 46.5 52.5 39.2 49.0 60.5 58.2 52.5 44.8 57.8 78.6 66.0 22.4 28.6 4.6 2.8 18.6 12.4 12.8 13.1 9.1 16.8 15.1 4.6 17.2 15.9 46.0 2.1 5.6 2.7 20.1 3.9 18.6 1.8 23.8 16.9 16.6 18.0 4.2 10.5 19.8 19.1 32.7 18.3 59.7 2.5 11.5 7.9 43.7 4.9 1.7 11.8 23.2 10.2 3.5 12.2 2.0 12.2 3.9 10.6 7.5 0.3 1.5 1.0 9.5 118.2 33.5 14.6 7.5 7.7 39.1 51.0 25.8 7.2 2.8 0.0 9.5 11.1 8.4 8.7 16.9 19.2 10.3 5.1 7.5 27.2 22.1 ZFP91 "PZF, ZNF757" ENSG00000186660 "ZFP91 zinc finger protein, atypical E3 ubiquitin ligase" Q96JP5 11 58579063-58621550 "Enzymes, Predicted intracellular proteins, Transcription factors" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Early spermatids: 243.7;Late spermatids: 179.3;Spermatocytes: 140.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Low immune cell specificity" "Detected in many" "Low lineage specificity" "Detected in all" "Low cell line specificity" "Detected in all" "HPA024037, CAB025417, HPA065325" Approved Supported Nucleoplasm,Nucleoli NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 23: Testis - Cell cycle regulation" "Cluster 18: U-2197 - ECM organization" "Cluster 10: Non-specific - Unknown function" "Nucleoplasm, Nucleoli" "CAB025417: , HPA024037: AB_1859051, HPA065325: AB_2685468" "unprognostic (6.10e-2)" "unprognostic (5.01e-2)" "unprognostic (3.33e-3)" "unprognostic (9.19e-2)" "unprognostic (1.24e-1)" "unprognostic (2.33e-1)" "unprognostic (2.33e-2)" "unprognostic (3.37e-2)" "unprognostic (1.06e-1)" "unprognostic (2.36e-2)" "prognostic unfavorable (3.74e-6)" "unprognostic (3.16e-1)" "unprognostic (1.75e-3)" "unprognostic (3.12e-2)" "unprognostic (2.61e-1)" "unprognostic (2.23e-1)" "unprognostic (2.00e-3)" 25.0 22.0 27.8 23.0 32.3 59.2 21.9 28.0 33.4 22.0 16.0 28.9 25.9 22.4 17.6 24.4 19.9 21.5 29.8 22.9 26.9 25.1 30.7 21.3 24.8 26.5 28.8 20.2 22.8 29.8 15.3 20.3 27.1 19.3 33.5 29.8 20.2 22.6 53.2 25.7 29.0 24.4 28.8 24.3 21.1 86.4 28.4 36.7 25.9 45.3 26.2 27.5 20.4 32.8 65.4 36.3 42.0 43.3 39.6 47.5 23.1 52.3 98.3 59.6 50.7 19.9 67.1 77.5 50.6 66.9 59.4 56.7 43.2 56.0 77.9 41.3 24.3 51.2 36.5 21.9 44.9 65.3 80.9 41.8 53.8 83.9 97.3 49.4 60.0 51.5 51.4 71.4 77.7 21.7 56.8 36.1 22.2 37.6 35.4 43.4 71.0 51.8 43.8 60.9 45.1 35.9 67.2 61.0 86.8 22.7 68.2 48.5 67.8 74.8 51.4 114.0 59.3 41.0 32.3 62.9 66.2 36.1 78.1 1.3 1.4 1.0 1.5 1.2 0.8 1.3 0.9 0.9 1.4 1.1 0.9 1.2 1.5 1.0 1.3 2.0 0.8 0.8 27.8 32.3 28.0 33.4 22.9 26.9 26.5 28.8 27.1 28.8 28.4 32.8 24.6 25.6 33.6 0.0 29.1 60.2 26.1 20.6 44.3 31.9 25.4 17.9 45.7 38.6 20.6 18.4 16.7 12.1 31.7 46.2 13.7 23.7 243.7 30.1 33.7 28.8 25.2 46.7 0.0 31.2 11.4 31.3 23.9 40.9 50.6 32.5 27.5 51.3 16.6 35.3 0.0 27.6 12.2 45.3 55.9 179.3 30.7 36.5 23.2 0.0 36.4 21.1 25.7 0.0 0.0 29.5 18.6 27.1 26.2 35.0 34.6 26.7 24.2 22.4 19.7 34.7 27.6 140.9 41.1 53.7 66.5 13.8 24.2 17.9 39.1 43.4 ZNRF1 "DKFZp434E229, FLJ14846, nin283" ENSG00000186187 "Zinc and ring finger 1" Q8ND25 16 74999024-75110994 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Low cell type specificity" "Detected in many" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "basophil: 2.4;T-reg: 2.4" "Group enriched" "Detected in many" 4 "granulocytes: 2.4;T-cells: 2.4" "Cell line enhanced" "Detected in all" "HMC-1: 176.9;MOLT-4: 134.6" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA027470 Approved NA NA "Cluster 10: Basophils - Unknown function" "Cluster 59: Non-specific - Translation" "Cluster 3: HMC-1 - Innate immune response" "Cluster 44: Endometrium - Transcription" "HPA027470: AB_10603108" "unprognostic (2.78e-2)" "prognostic favorable (9.90e-4)" "unprognostic (4.45e-3)" "unprognostic (1.51e-1)" "unprognostic (4.34e-2)" "unprognostic (1.18e-2)" "unprognostic (2.51e-1)" "unprognostic (2.07e-1)" "unprognostic (1.12e-2)" "unprognostic (5.38e-2)" "unprognostic (3.69e-1)" "unprognostic (2.28e-1)" "unprognostic (1.46e-1)" "unprognostic (4.89e-2)" "unprognostic (2.87e-1)" "unprognostic (2.10e-2)" "unprognostic (1.44e-2)" 18.7 16.5 21.1 9.6 22.3 6.7 17.8 9.1 22.8 25.3 19.0 30.6 9.6 22.5 9.5 65.9 18.0 7.5 21.0 23.4 24.5 14.7 17.6 24.1 7.7 19.6 22.5 17.4 11.5 11.8 13.4 11.2 18.6 13.7 12.1 7.4 16.9 7.0 81.2 25.0 15.3 11.4 13.4 4.5 21.0 37.4 30.7 53.2 29.3 30.6 13.3 22.5 26.4 17.5 10.9 15.7 26.7 27.5 27.7 21.4 91.2 13.0 18.3 17.5 17.1 25.4 33.2 2.9 9.9 28.3 16.8 25.5 13.0 17.8 13.9 26.7 7.5 56.7 4.8 47.0 22.0 27.5 176.9 19.5 14.7 18.4 14.9 30.8 29.0 68.3 27.8 8.8 13.7 104.5 134.6 100.6 37.1 31.4 16.7 59.0 10.0 17.4 25.1 30.5 35.4 37.7 20.7 27.0 8.3 21.7 71.6 25.8 19.9 12.0 21.0 21.5 7.9 50.5 55.1 31.6 15.8 30.2 12.6 2.4 0.5 0.4 0.0 0.5 0.5 0.0 0.6 0.0 0.3 0.0 0.0 0.1 0.5 0.0 0.5 0.0 2.4 0.1 21.1 22.3 9.1 22.8 23.4 24.5 19.6 22.5 18.6 13.4 30.7 17.5 34.8 9.6 14.4 16.6 1.8 15.9 16.0 11.2 4.6 12.6 24.3 22.4 16.4 18.6 14.0 3.7 52.1 6.4 2.3 25.5 0.0 8.9 25.9 30.7 15.1 30.2 19.8 30.5 45.2 12.7 10.1 15.1 18.3 28.0 36.8 23.7 12.8 14.4 10.4 3.3 42.4 14.0 14.2 7.3 10.9 16.3 6.8 7.3 14.2 33.7 7.6 15.0 0.0 33.7 29.5 20.0 12.1 4.1 1.8 17.2 9.6 6.2 15.1 6.5 0.0 12.4 14.7 13.6 18.7 21.0 19.6 4.5 13.3 16.7 12.7 29.6 ZNRF2 RNF202 ENSG00000180233 "Zinc and ring finger 2" Q8NHG8 7 30284597-30367689 "Enzymes, Metabolic proteins, Predicted intracellular proteins" "Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in all" "Cell type enhanced" "Detected in many" "Microglial cells: 119.9" "Low cancer specificity" "Detected in all" "Low region specificity" "Detected in all" "Immune cell enhanced" "Detected in some" "plasmacytoid DC: 2.2" "Low lineage specificity" "Detected in many" "Low cell line specificity" "Detected in all" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" HPA072244 Approved Uncertain "Nucleoplasm,Nucleoli fibrillar center,Vesicles" NA NA "Cluster 47: Plasmacytoid DCs - Protein folding" "Cluster 87: Intestine & Kidney - Transmembrane transport" "Cluster 25: RPMI-8226 - Immune response" "Cluster 24: Non-specific - Transcription regulation" "Nucleoplasm, Vesicles" "Nucleoli fibrillar center" "HPA072244: AB_2732197" "unprognostic (9.44e-2)" "unprognostic (2.38e-2)" "unprognostic (8.64e-2)" "prognostic unfavorable (7.68e-4)" "unprognostic (4.46e-2)" "unprognostic (1.24e-1)" "unprognostic (3.06e-1)" "unprognostic (6.10e-2)" "unprognostic (1.26e-1)" "unprognostic (1.67e-1)" "unprognostic (1.71e-1)" "unprognostic (5.93e-2)" "prognostic favorable (2.29e-4)" "unprognostic (1.51e-1)" "unprognostic (2.71e-1)" "prognostic favorable (8.71e-4)" "unprognostic (8.67e-2)" 7.4 6.5 4.8 11.5 5.3 13.0 9.6 5.5 4.2 5.1 14.5 18.9 13.2 8.4 10.7 10.4 4.4 9.4 5.1 4.3 4.0 22.0 21.5 7.4 15.3 7.4 6.6 3.7 10.3 9.1 5.0 9.3 6.0 5.7 16.2 4.7 9.2 5.3 5.7 10.0 15.2 9.5 7.5 10.8 15.0 24.0 7.9 8.9 11.7 6.2 13.2 11.2 4.2 8.4 13.2 4.7 3.8 3.4 4.4 3.0 19.8 4.9 5.1 5.4 7.2 2.4 21.5 13.8 12.6 4.1 14.0 12.5 12.7 8.5 5.7 13.4 11.5 8.6 9.7 6.4 2.3 6.7 15.6 4.6 14.0 3.7 9.1 5.6 4.6 10.5 10.7 26.6 5.9 5.1 13.6 17.5 8.9 13.2 5.9 11.7 8.2 23.8 16.4 28.0 13.0 12.3 9.9 41.2 8.5 22.2 11.1 26.5 5.1 5.2 8.9 5.0 10.5 44.9 41.5 18.1 5.7 14.3 7.8 0.2 0.3 0.4 0.3 0.3 0.5 0.4 0.4 0.5 0.3 0.2 0.2 0.4 0.5 0.3 0.4 2.2 1.0 0.2 4.8 5.3 5.5 4.2 4.3 4.0 7.4 6.6 6.0 7.5 7.9 8.4 11.3 9.6 8.4 19.9 13.9 15.9 7.4 4.8 8.6 11.3 26.5 10.4 3.6 14.3 5.0 16.5 41.7 10.1 40.8 60.0 7.9 4.9 5.2 32.7 7.6 6.6 31.3 6.1 54.4 10.3 11.4 5.1 14.3 43.7 3.8 4.7 8.2 41.6 10.7 1.7 32.3 14.0 0.0 23.3 16.2 10.1 2.8 23.1 12.4 119.9 13.1 5.1 4.1 41.7 39.7 7.4 19.5 2.2 11.5 8.5 22.6 32.3 5.8 5.8 6.6 7.7 9.8 18.3 7.0 7.9 18.9 11.5 17.6 7.6 23.4 14.3 ZNRF3 "BK747E2.3, FLJ22057, KIAA1133, RNF203" ENSG00000183579 "Zinc and ring finger 3" Q9ULT6 22 28883572-29057488 "Enzymes, Predicted membrane proteins" "Ubl conjugation pathway, Wnt signaling pathway" "Developmental protein, Transferase" "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Low tissue specificity" "Detected in many" "Cell type enriched" "Detected in many" 6 "Astrocytes: 504.1" "Not detected" "Not detected" "Low region specificity" "Detected in all" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Cell line enhanced" "Detected in many" "Hep G2: 46.1" "Low region specificity" "Detected in all" "Low region specificity" "Detected in all" "HPA036702, HPA036703" Uncertain Uncertain "Golgi apparatus" NA NA "Cluster 48: NK-cells - Unknown function" "Cluster 68: Epididymis - Unknown function" "Cluster 37: Hep G2 - Hepatocyte cell processes" "Cluster 64: Astrocytes - Nervous system maintenance" "Golgi apparatus" "HPA036702: , HPA036703: AB_10672227" "unprognostic (1.07e-1)" "unprognostic (2.13e-3)" "unprognostic (7.48e-3)" "unprognostic (5.72e-2)" "unprognostic (6.81e-2)" "unprognostic (1.36e-1)" "unprognostic (2.22e-2)" "unprognostic (1.75e-2)" "unprognostic (1.37e-1)" "unprognostic (3.68e-2)" "unprognostic (5.18e-2)" "unprognostic (3.94e-1)" "unprognostic (9.55e-5)" "unprognostic (6.49e-2)" "unprognostic (1.02e-1)" "unprognostic (3.70e-2)" "unprognostic (2.55e-2)" 2.8 7.1 11.3 1.3 11.2 0.3 2.6 8.1 13.8 4.4 1.0 3.9 3.0 5.1 13.4 3.4 4.8 2.1 2.6 12.1 5.5 8.2 6.6 4.3 0.5 13.2 9.2 5.9 3.3 8.7 2.7 5.0 4.2 7.2 3.4 1.1 7.5 7.7 3.8 5.3 2.7 4.6 5.1 1.2 4.4 5.0 13.6 1.3 4.1 1.9 0.6 3.2 3.3 6.2 5.8 13.7 12.5 3.5 2.3 2.6 23.7 3.5 1.7 2.7 2.6 20.8 3.2 0.1 5.4 1.8 4.9 9.8 8.7 5.5 3.3 7.8 8.9 2.3 2.5 46.1 2.0 6.9 2.3 2.7 5.0 4.3 4.3 2.3 2.4 4.1 5.0 3.2 3.9 5.6 0.2 3.5 4.6 7.3 5.4 6.9 8.2 5.3 11.6 8.5 20.6 7.6 6.2 6.1 3.5 3.8 4.1 3.1 2.3 10.3 8.8 8.2 5.8 4.3 6.3 8.1 4.4 3.9 5.5 0.2 0.0 0.2 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.3 0.0 0.0 0.0 0.0 11.3 11.2 8.1 13.8 12.1 5.5 13.2 9.2 4.2 5.1 13.6 6.2 4.2 12.8 23.6 504.1 0.3 12.6 5.2 4.9 15.9 3.7 5.7 9.5 7.5 8.6 5.3 12.9 0.0 28.1 0.5 2.1 1.9 5.0 12.7 8.0 8.0 5.8 8.4 4.0 62.9 2.5 2.5 5.8 5.6 15.5 0.0 5.4 2.2 17.6 3.5 1.7 37.4 9.4 0.0 1.0 3.1 15.0 10.8 0.8 0.0 82.4 0.0 6.0 0.0 54.8 34.4 3.7 2.1 12.8 0.6 9.6 2.4 11.6 4.9 3.9 0.0 16.0 6.6 4.6 3.2 7.8 7.5 7.7 0.7 14.5 12.9 2.8 ZNRF4 "RNF204, spzn, Ssrzf1" ENSG00000105428 "Zinc and ring finger 4" Q8WWF5 19 5455417-5456856 "Enzymes, Predicted membrane proteins" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 905 "testis: 120.1" "Group enriched" "Detected in some" 62 "Early spermatids: 636.6;Late spermatids: 593.9" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" NA NA "Cluster 74: Testis - Spermatogenesis" "Cluster 31: Spermatids - Spermatogenesis" 0.0 0.0 0.1 0.0 0.1 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 120.1 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.1 0.1 0.1 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 636.6 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 593.9 5.3 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.8 3.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 ZSWIM2 "MEX, MGC33890, ZZZ2" ENSG00000163012 "Zinc finger SWIM-type containing 2" Q8NEG5 2 186827475-186849208 "Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins" "Apoptosis, Ubl conjugation pathway" Transferase "Evidence at protein level" "Evidence at transcript level" "Evidence at protein level" "Evidence at protein level" "Tissue enriched" "Detected in single" 13 "testis: 9.3" "Cell type enhanced" "Detected in some" "Early spermatids: 61.1;Late spermatids: 18.6;Spermatocytes: 11.5" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected in immune cells" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Not detected" "Low region specificity" "Detected in many" NA NA "Cluster 78: Testis - Spermatogenesis" "Cluster 23: Spermatids - Flagellum & Golgi organization" "unprognostic (2.00e-1)" 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 0.1 0.1 0.0 0.0 0.0 0.7 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 9.3 0.2 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.4 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.2 0.1 0.1 0.1 0.0 0.2 0.0 0.0 0.0 0.0 1.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.3 0.0 0.0 0.0 0.0 0.2 0.0 0.0 0.0 0.0 61.1 0.0 0.0 0.1 0.0 0.0 0.7 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.1 0.0 0.5 0.0 0.0 0.0 0.0 18.6 0.3 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 11.5 0.8 0.0 0.0 0.3 0.0 0.0 0.0 0.0