[{"Gene":"PRPF40B","Gene synonym":["HYPC"],"Ensembl":"ENSG00000110844","Gene description":"Pre-mRNA processing factor 40 homolog B","Uniprot":["Q6NWY9"],"Chromosome":"12","Position":"49568218-49644666","Protein class":["Predicted intracellular proteins"],"Biological process":["mRNA processing","mRNA splicing"],"Molecular function":null,"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Cell type enhanced","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":{"Spermatocytes":"61.3"},"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in many","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in some","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in many","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cell line specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA038426","HPA038599"],"Reliability (IH)":"Enhanced","Reliability (Mouse Brain)":null,"Reliability (IF)":"Approved","Subcellular location":["Nucleoplasm","Nuclear bodies","Aggresome","Cytosol"],"Secretome location":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 22: NK-cells - Unknown function","Tissue expression cluster":"Cluster 43: Testis - Unknown function","Cell line expression cluster":"Cluster 6: T47d - Mammary gland","Single cell expression cluster":"Cluster 13: Spermatocytes & Spermatogonia - Spermatogenesis","Subcellular main location":["Nuclear bodies"],"Subcellular additional location":["Nucleoplasm","Aggresome","Cytosol"],"Antibody RRID":{"HPA038426":"AB_10674684","HPA038599":"AB_10674689"},"Pathology prognostics - Breast cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.03e-1"},"Pathology prognostics - Cervical cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.32e-2"},"Pathology prognostics - Colorectal cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.44e-3"},"Pathology prognostics - Endometrial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.36e-2"},"Pathology prognostics - Glioma":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.83e-1"},"Pathology prognostics - Head and neck cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.47e-1"},"Pathology prognostics - Liver cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"7.50e-6"},"Pathology prognostics - Lung cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.02e-1"},"Pathology prognostics - Melanoma":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.56e-1"},"Pathology prognostics - Ovarian cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.45e-1"},"Pathology prognostics - Pancreatic cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"5.06e-3"},"Pathology prognostics - Prostate cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.31e-1"},"Pathology prognostics - Renal cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.29e-3"},"Pathology prognostics - Stomach cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.23e-2"},"Pathology prognostics - Testis cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.05e-1"},"Pathology prognostics - Thyroid cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.01e-1"},"Pathology prognostics - Urothelial cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.80e-2"},"Tissue RNA - adipose tissue [nTPM]":"8.3","Tissue RNA - adrenal gland [nTPM]":"16.3","Tissue RNA - amygdala [nTPM]":"16.3","Tissue RNA - appendix [nTPM]":"3.2","Tissue RNA - basal ganglia [nTPM]":"15.6","Tissue RNA - bone marrow [nTPM]":"0.7","Tissue RNA - breast [nTPM]":"11.5","Tissue RNA - cerebellum [nTPM]":"13.3","Tissue RNA - cerebral cortex [nTPM]":"18.8","Tissue RNA - cervix [nTPM]":"23.9","Tissue RNA - choroid plexus [nTPM]":"13.7","Tissue RNA - colon [nTPM]":"15.6","Tissue RNA - duodenum [nTPM]":"4.0","Tissue RNA - endometrium 1 [nTPM]":"17.9","Tissue RNA - epididymis [nTPM]":"10.4","Tissue RNA - esophagus [nTPM]":"10.4","Tissue RNA - fallopian tube [nTPM]":"19.1","Tissue RNA - gallbladder [nTPM]":"6.4","Tissue RNA - heart muscle [nTPM]":"15.6","Tissue RNA - hippocampal formation [nTPM]":"16.6","Tissue RNA - hypothalamus [nTPM]":"16.5","Tissue RNA - kidney [nTPM]":"23.9","Tissue RNA - liver [nTPM]":"9.2","Tissue RNA - lung [nTPM]":"7.4","Tissue RNA - lymph node [nTPM]":"3.1","Tissue RNA - medulla oblongata [nTPM]":"16.4","Tissue RNA - midbrain [nTPM]":"14.5","Tissue RNA - ovary [nTPM]":"25.4","Tissue RNA - pancreas [nTPM]":"16.0","Tissue RNA - parathyroid gland [nTPM]":"20.3","Tissue RNA - pituitary gland [nTPM]":"26.2","Tissue RNA - placenta [nTPM]":"6.5","Tissue RNA - pons [nTPM]":"15.9","Tissue RNA - prostate [nTPM]":"17.5","Tissue RNA - rectum [nTPM]":"3.4","Tissue RNA - retina [nTPM]":"12.3","Tissue RNA - salivary gland [nTPM]":"13.3","Tissue RNA - seminal vesicle [nTPM]":"11.7","Tissue RNA - skeletal muscle [nTPM]":"25.2","Tissue RNA - skin 1 [nTPM]":"11.4","Tissue RNA - small intestine [nTPM]":"7.6","Tissue RNA - smooth muscle [nTPM]":"7.8","Tissue RNA - spinal cord [nTPM]":"13.3","Tissue RNA - spleen [nTPM]":"9.5","Tissue RNA - stomach 1 [nTPM]":"14.5","Tissue RNA - testis [nTPM]":"33.7","Tissue RNA - thalamus [nTPM]":"14.7","Tissue RNA - thymus [nTPM]":"3.5","Tissue RNA - thyroid gland [nTPM]":"29.2","Tissue RNA - tongue [nTPM]":"13.5","Tissue RNA - tonsil [nTPM]":"3.4","Tissue RNA - urinary bladder [nTPM]":"14.6","Tissue RNA - vagina [nTPM]":"14.6","Tissue RNA - white matter [nTPM]":"15.3","Cell RNA - A-431 [nTPM]":"7.2","Cell RNA - A549 [nTPM]":"10.5","Cell RNA - AF22 [nTPM]":"10.3","Cell RNA - AN3-CA [nTPM]":"10.0","Cell RNA - ASC diff [nTPM]":"8.4","Cell RNA - ASC TERT1 [nTPM]":"5.4","Cell RNA - BEWO [nTPM]":"9.5","Cell RNA - BJ [nTPM]":"5.8","Cell RNA - BJ hTERT+ [nTPM]":"8.1","Cell RNA - BJ hTERT+ SV40 Large T+ [nTPM]":"6.1","Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [nTPM]":"3.0","Cell RNA - CACO-2 [nTPM]":"12.2","Cell RNA - CAPAN-2 [nTPM]":"15.8","Cell RNA - Daudi [nTPM]":"5.8","Cell RNA - EFO-21 [nTPM]":"12.0","Cell RNA - fHDF\/TERT166 [nTPM]":"7.7","Cell RNA - GAMG [nTPM]":"8.6","Cell RNA - HaCaT [nTPM]":"4.2","Cell RNA - HAP1 [nTPM]":"6.3","Cell RNA - HBEC3-KT [nTPM]":"20.1","Cell RNA - HBF TERT88 [nTPM]":"3.1","Cell RNA - HDLM-2 [nTPM]":"4.4","Cell RNA - HEK 293 [nTPM]":"2.5","Cell RNA - HEL [nTPM]":"6.1","Cell RNA - HeLa [nTPM]":"4.2","Cell RNA - Hep G2 [nTPM]":"4.4","Cell RNA - HHSteC [nTPM]":"10.6","Cell RNA - HL-60 [nTPM]":"2.0","Cell RNA - HMC-1 [nTPM]":"7.8","Cell RNA - HSkMC [nTPM]":"7.7","Cell RNA - hTCEpi [nTPM]":"16.8","Cell RNA - hTEC\/SVTERT24-B [nTPM]":"6.1","Cell RNA - hTERT-HME1 [nTPM]":"22.0","Cell RNA - hTERT-RPE1 [nTPM]":"13.2","Cell RNA - HUVEC TERT2 [nTPM]":"4.9","Cell RNA - JURKAT [nTPM]":"11.7","Cell RNA - K-562 [nTPM]":"3.0","Cell RNA - Karpas-707 [nTPM]":"3.0","Cell RNA - LHCN-M2 [nTPM]":"7.3","Cell RNA - MCF7 [nTPM]":"6.7","Cell RNA - MOLT-4 [nTPM]":"1.4","Cell RNA - NB-4 [nTPM]":"4.2","Cell RNA - NTERA-2 [nTPM]":"4.4","Cell RNA - OE19 [nTPM]":"8.2","Cell RNA - PC-3 [nTPM]":"3.9","Cell RNA - REH [nTPM]":"5.1","Cell RNA - RH-30 [nTPM]":"1.6","Cell RNA - RPMI-8226 [nTPM]":"4.8","Cell RNA - RPTEC TERT1 [nTPM]":"13.0","Cell RNA - RT4 [nTPM]":"6.6","Cell RNA - SCLC-21H [nTPM]":"10.9","Cell RNA - SH-SY5Y [nTPM]":"13.1","Cell RNA - SiHa [nTPM]":"4.7","Cell RNA - SK-BR-3 [nTPM]":"12.8","Cell RNA - SK-MEL-30 [nTPM]":"7.2","Cell RNA - SuSa [nTPM]":"9.4","Cell RNA - T-47d [nTPM]":"24.5","Cell RNA - THP-1 [nTPM]":"5.7","Cell RNA - TIME [nTPM]":"2.0","Cell RNA - U-138 MG [nTPM]":"3.7","Cell RNA - U-2 OS [nTPM]":"14.9","Cell RNA - U-2197 [nTPM]":"4.9","Cell RNA - U-251 MG [nTPM]":"2.5","Cell RNA - U-266\/70 [nTPM]":"7.1","Cell RNA - U-266\/84 [nTPM]":"4.3","Cell RNA - U-698 [nTPM]":"2.4","Cell RNA - U-87 MG [nTPM]":"11.2","Cell RNA - U-937 [nTPM]":"1.5","Cell RNA - WM-115 [nTPM]":"3.5","Blood RNA - basophil [nTPM]":"0.0","Blood RNA - classical monocyte [nTPM]":"0.1","Blood RNA - eosinophil [nTPM]":"0.0","Blood RNA - gdT-cell [nTPM]":"0.8","Blood RNA - intermediate monocyte [nTPM]":"0.1","Blood RNA - MAIT T-cell [nTPM]":"1.1","Blood RNA - memory B-cell [nTPM]":"0.3","Blood RNA - memory CD4 T-cell [nTPM]":"0.8","Blood RNA - memory CD8 T-cell [nTPM]":"0.3","Blood RNA - myeloid DC [nTPM]":"0.2","Blood RNA - naive B-cell [nTPM]":"0.6","Blood RNA - naive CD4 T-cell [nTPM]":"0.8","Blood RNA - naive CD8 T-cell [nTPM]":"0.9","Blood RNA - neutrophil [nTPM]":"0.0","Blood RNA - NK-cell [nTPM]":"1.3","Blood RNA - non-classical monocyte [nTPM]":"0.0","Blood RNA - plasmacytoid DC [nTPM]":"0.5","Blood RNA - T-reg [nTPM]":"0.3","Blood RNA - total PBMC [nTPM]":"0.3","Brain RNA - amygdala [nTPM]":"16.3","Brain RNA - basal ganglia [nTPM]":"15.6","Brain RNA - cerebellum [nTPM]":"13.3","Brain RNA - cerebral cortex [nTPM]":"18.8","Brain RNA - hippocampal formation [nTPM]":"16.6","Brain RNA - hypothalamus [nTPM]":"16.5","Brain RNA - medulla oblongata [nTPM]":"16.4","Brain RNA - midbrain [nTPM]":"14.5","Brain RNA - pons [nTPM]":"15.9","Brain RNA - spinal cord [nTPM]":"13.3","Brain RNA - thalamus [nTPM]":"14.7","Brain RNA - white matter [nTPM]":"15.3","Single Cell Type RNA - Adipocytes [nTPM]":"5.3","Single Cell Type RNA - Alveolar cells type 1 [nTPM]":"12.8","Single Cell Type RNA - Alveolar cells type 2 [nTPM]":"20.3","Single Cell Type RNA - Astrocytes [nTPM]":"15.7","Single Cell Type RNA - B-cells [nTPM]":"4.1","Single Cell Type RNA - Basal keratinocytes [nTPM]":"3.6","Single Cell Type RNA - Basal prostatic cells [nTPM]":"8.7","Single Cell Type RNA - Basal respiratory cells [nTPM]":"10.2","Single Cell Type RNA - Basal squamous epithelial cells [nTPM]":"11.4","Single Cell Type RNA - Bipolar cells [nTPM]":"19.1","Single Cell Type RNA - Breast glandular cells [nTPM]":"6.6","Single Cell Type RNA - Breast myoepithelial cells [nTPM]":"9.7","Single Cell Type RNA - Cardiomyocytes [nTPM]":"1.2","Single Cell Type RNA - Cholangiocytes [nTPM]":"5.7","Single Cell Type RNA - Club cells [nTPM]":"17.5","Single Cell Type RNA - Collecting duct cells [nTPM]":"18.4","Single Cell Type RNA - Cone photoreceptor cells [nTPM]":"10.4","Single Cell Type RNA - Cytotrophoblasts [nTPM]":"21.9","Single Cell Type RNA - dendritic cells [nTPM]":"1.2","Single Cell Type RNA - Distal enterocytes [nTPM]":"1.5","Single Cell Type RNA - Distal tubular cells [nTPM]":"7.9","Single Cell Type RNA - Ductal cells [nTPM]":"13.8","Single Cell Type RNA - Early spermatids [nTPM]":"28.9","Single Cell Type RNA - Endometrial ciliated cells [nTPM]":"8.6","Single Cell Type RNA - Endometrial stromal cells [nTPM]":"7.5","Single Cell Type RNA - Endothelial cells [nTPM]":"5.2","Single Cell Type RNA - Enteroendocrine cells [nTPM]":"7.7","Single Cell Type RNA - Erythroid cells [nTPM]":"3.0","Single Cell Type RNA - Excitatory neurons [nTPM]":"19.3","Single Cell Type RNA - Exocrine glandular cells [nTPM]":"11.1","Single Cell Type RNA - Extravillous trophoblasts [nTPM]":"7.4","Single Cell Type RNA - Fibroblasts [nTPM]":"7.2","Single Cell Type RNA - Gastric mucus-secreting cells [nTPM]":"4.1","Single Cell Type RNA - Glandular and luminal cells [nTPM]":"5.6","Single Cell Type RNA - granulocytes [nTPM]":"2.5","Single Cell Type RNA - Granulosa cells [nTPM]":"15.6","Single Cell Type RNA - Hepatic stellate cells [nTPM]":"8.2","Single Cell Type RNA - Hepatocytes [nTPM]":"3.1","Single Cell Type RNA - Hofbauer cells [nTPM]":"5.4","Single Cell Type RNA - Horizontal cells [nTPM]":"11.8","Single Cell Type RNA - Inhibitory neurons [nTPM]":"22.9","Single Cell Type RNA - Intestinal goblet cells [nTPM]":"3.2","Single Cell Type RNA - Ionocytes [nTPM]":"12.2","Single Cell Type RNA - Kupffer cells [nTPM]":"1.6","Single Cell Type RNA - Langerhans cells [nTPM]":"2.1","Single Cell Type RNA - Late spermatids [nTPM]":"23.1","Single Cell Type RNA - Leydig cells [nTPM]":"11.8","Single Cell Type RNA - Macrophages [nTPM]":"1.5","Single Cell Type RNA - Melanocytes [nTPM]":"3.6","Single Cell Type RNA - Microglial cells [nTPM]":"6.5","Single Cell Type RNA - monocytes [nTPM]":"4.9","Single Cell Type RNA - Muller glia cells [nTPM]":"8.3","Single Cell Type RNA - NK-cells [nTPM]":"2.1","Single Cell Type RNA - Oligodendrocyte precursor cells [nTPM]":"20.6","Single Cell Type RNA - Oligodendrocytes [nTPM]":"17.2","Single Cell Type RNA - Pancreatic endocrine cells [nTPM]":"6.8","Single Cell Type RNA - Paneth cells [nTPM]":"1.1","Single Cell Type RNA - Peritubular cells [nTPM]":"12.0","Single Cell Type RNA - Plasma cells [nTPM]":"1.1","Single Cell Type RNA - Prostatic glandular cells [nTPM]":"6.7","Single Cell Type RNA - Proximal enterocytes [nTPM]":"1.4","Single Cell Type RNA - Proximal tubular cells [nTPM]":"5.6","Single Cell Type RNA - Respiratory ciliated cells [nTPM]":"24.5","Single Cell Type RNA - Rod photoreceptor cells [nTPM]":"19.8","Single Cell Type RNA - Sertoli cells [nTPM]":"13.1","Single Cell Type RNA - Skeletal myocytes [nTPM]":"9.8","Single Cell Type RNA - Smooth muscle cells [nTPM]":"9.7","Single Cell Type RNA - Spermatocytes [nTPM]":"61.3","Single Cell Type RNA - Spermatogonia [nTPM]":"26.6","Single Cell Type RNA - Squamous epithelial cells [nTPM]":"8.0","Single Cell Type RNA - Suprabasal keratinocytes [nTPM]":"6.0","Single Cell Type RNA - Syncytiotrophoblasts [nTPM]":"26.4","Single Cell Type RNA - T-cells [nTPM]":"3.1","Single Cell Type RNA - Theca cells [nTPM]":"9.2","Single Cell Type RNA - Undifferentiated cells [nTPM]":"5.2","Single Cell Type RNA - Urothelial cells [nTPM]":"5.0"}]