[{"Gene":"CLTC","Gene synonym":["CLTCL2","Hc"],"Ensembl":"ENSG00000141367","Gene description":"Clathrin heavy chain","Uniprot":["Q00610"],"Chromosome":"17","Position":"59619689-59696956","Protein class":["Cancer-related genes","Disease related genes","Human disease related genes","Plasma proteins","Potential drug targets","Predicted intracellular proteins","Transporters"],"Biological process":["Autophagy","Cell cycle","Cell division","Mitosis"],"Molecular function":null,"Disease involvement":["Cancer-related genes","Disease variant","Mental retardation"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cell line specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["CAB010389","CAB011571","CAB017155","HPA059143"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Vesicles","Endosomes","Lysosomes","Mitotic spindle","Cytosol"],"Secretome location":null,"CCD Protein":"Yes","CCD Transcript":"No","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":"14000000","Blood expression cluster":"Cluster 27: Non-specific - Gene expression","Tissue expression cluster":"Cluster 48: Parathyroid gland - membrane proteins","Cell line expression cluster":"Cluster 40: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 10: Non-specific - Unknown function","Subcellular main location":["Vesicles","Endosomes","Lysosomes"],"Subcellular additional location":["Mitotic spindle","Cytosol"],"Antibody RRID":{"CAB010389":"AB_2083184","CAB011571":"AB_2083165","CAB017155":null,"HPA059143":"AB_2683924"},"Pathology prognostics - Breast cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.56e-1"},"Pathology prognostics - Cervical cancer":{"prognostic type":"unfavorable","is_prognostic":true,"p_val":"7.35e-4"},"Pathology prognostics - Colorectal cancer":{"prognostic type":"favorable","is_prognostic":true,"p_val":"7.65e-4"},"Pathology prognostics - Endometrial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.03e-1"},"Pathology prognostics - Glioma":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.62e-1"},"Pathology prognostics - Head and neck cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.23e-3"},"Pathology prognostics - Liver cancer":{"prognostic type":"unfavorable","is_prognostic":true,"p_val":"5.54e-4"},"Pathology prognostics - Lung cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.11e-1"},"Pathology prognostics - Melanoma":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"6.43e-2"},"Pathology prognostics - Ovarian cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.09e-1"},"Pathology prognostics - Pancreatic cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"3.34e-2"},"Pathology prognostics - Prostate cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.69e-1"},"Pathology prognostics - Renal cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.49e-1"},"Pathology prognostics - Stomach cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.18e-1"},"Pathology prognostics - Testis cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.22e-2"},"Pathology prognostics - Thyroid cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.10e-1"},"Pathology prognostics - Urothelial cancer":{"prognostic type":"unfavorable","is_prognostic":true,"p_val":"2.02e-4"},"Tissue RNA - adipose tissue [nTPM]":"105.4","Tissue RNA - adrenal gland [nTPM]":"95.2","Tissue RNA - amygdala [nTPM]":"42.1","Tissue RNA - appendix [nTPM]":"89.7","Tissue RNA - basal ganglia [nTPM]":"54.9","Tissue RNA - bone marrow [nTPM]":"96.3","Tissue RNA - breast [nTPM]":"81.6","Tissue RNA - cerebellum [nTPM]":"67.3","Tissue RNA - cerebral cortex [nTPM]":"103.9","Tissue RNA - cervix [nTPM]":"92.3","Tissue RNA - choroid plexus [nTPM]":"36.7","Tissue RNA - colon [nTPM]":"121.7","Tissue RNA - duodenum [nTPM]":"74.1","Tissue RNA - endometrium 1 [nTPM]":"83.1","Tissue RNA - epididymis [nTPM]":"126.4","Tissue RNA - esophagus [nTPM]":"82.1","Tissue RNA - fallopian tube [nTPM]":"67.8","Tissue RNA - gallbladder [nTPM]":"88.9","Tissue RNA - heart muscle [nTPM]":"90.7","Tissue RNA - hippocampal formation [nTPM]":"60.7","Tissue RNA - hypothalamus [nTPM]":"65.1","Tissue RNA - kidney [nTPM]":"125.5","Tissue RNA - liver [nTPM]":"117.7","Tissue RNA - lung [nTPM]":"82.1","Tissue RNA - lymph node [nTPM]":"75.5","Tissue RNA - medulla oblongata [nTPM]":"95.5","Tissue RNA - midbrain [nTPM]":"52.4","Tissue RNA - ovary [nTPM]":"73.2","Tissue RNA - pancreas [nTPM]":"56.8","Tissue RNA - parathyroid gland [nTPM]":"186.8","Tissue RNA - pituitary gland [nTPM]":"51.6","Tissue RNA - placenta [nTPM]":"139.6","Tissue RNA - pons [nTPM]":"95.2","Tissue RNA - prostate [nTPM]":"97.8","Tissue RNA - rectum [nTPM]":"128.3","Tissue RNA - retina [nTPM]":"163.6","Tissue RNA - salivary gland [nTPM]":"68.6","Tissue RNA - seminal vesicle [nTPM]":"104.2","Tissue RNA - skeletal muscle [nTPM]":"88.4","Tissue RNA - skin 1 [nTPM]":"81.3","Tissue RNA - small intestine [nTPM]":"73.3","Tissue RNA - smooth muscle [nTPM]":"121.0","Tissue RNA - spinal cord [nTPM]":"43.8","Tissue RNA - spleen [nTPM]":"78.8","Tissue RNA - stomach 1 [nTPM]":"91.2","Tissue RNA - testis [nTPM]":"71.3","Tissue RNA - thalamus [nTPM]":"68.2","Tissue RNA - thymus [nTPM]":"76.0","Tissue RNA - thyroid gland [nTPM]":"114.1","Tissue RNA - tongue [nTPM]":"83.9","Tissue RNA - tonsil [nTPM]":"86.8","Tissue RNA - urinary bladder [nTPM]":"101.1","Tissue RNA - vagina [nTPM]":"51.6","Tissue RNA - white matter [nTPM]":"55.0","Cell RNA - A-431 [nTPM]":"293.3","Cell RNA - A549 [nTPM]":"426.1","Cell RNA - AF22 [nTPM]":"207.6","Cell RNA - AN3-CA [nTPM]":"207.0","Cell RNA - ASC diff [nTPM]":"345.8","Cell RNA - ASC TERT1 [nTPM]":"280.5","Cell RNA - BEWO [nTPM]":"240.0","Cell RNA - BJ [nTPM]":"305.7","Cell RNA - BJ hTERT+ [nTPM]":"321.7","Cell RNA - BJ hTERT+ SV40 Large T+ [nTPM]":"268.2","Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [nTPM]":"278.9","Cell RNA - CACO-2 [nTPM]":"264.7","Cell RNA - CAPAN-2 [nTPM]":"175.2","Cell RNA - Daudi [nTPM]":"200.6","Cell RNA - EFO-21 [nTPM]":"340.1","Cell RNA - fHDF\/TERT166 [nTPM]":"436.4","Cell RNA - GAMG [nTPM]":"296.9","Cell RNA - HaCaT [nTPM]":"186.2","Cell RNA - HAP1 [nTPM]":"313.6","Cell RNA - HBEC3-KT [nTPM]":"255.1","Cell RNA - HBF TERT88 [nTPM]":"356.2","Cell RNA - HDLM-2 [nTPM]":"214.4","Cell RNA - HEK 293 [nTPM]":"166.8","Cell RNA - HEL [nTPM]":"328.2","Cell RNA - HeLa [nTPM]":"248.8","Cell RNA - Hep G2 [nTPM]":"414.0","Cell RNA - HHSteC [nTPM]":"262.3","Cell RNA - HL-60 [nTPM]":"228.5","Cell RNA - HMC-1 [nTPM]":"182.3","Cell RNA - HSkMC [nTPM]":"266.9","Cell RNA - hTCEpi [nTPM]":"154.6","Cell RNA - hTEC\/SVTERT24-B [nTPM]":"408.0","Cell RNA - hTERT-HME1 [nTPM]":"262.3","Cell RNA - hTERT-RPE1 [nTPM]":"211.4","Cell RNA - HUVEC TERT2 [nTPM]":"302.0","Cell RNA - JURKAT [nTPM]":"99.9","Cell RNA - K-562 [nTPM]":"334.4","Cell RNA - Karpas-707 [nTPM]":"280.4","Cell RNA - LHCN-M2 [nTPM]":"429.1","Cell RNA - MCF7 [nTPM]":"511.1","Cell RNA - MOLT-4 [nTPM]":"135.6","Cell RNA - NB-4 [nTPM]":"65.1","Cell RNA - NTERA-2 [nTPM]":"179.6","Cell RNA - OE19 [nTPM]":"263.3","Cell RNA - PC-3 [nTPM]":"248.2","Cell RNA - REH [nTPM]":"118.7","Cell RNA - RH-30 [nTPM]":"343.6","Cell RNA - RPMI-8226 [nTPM]":"244.9","Cell RNA - RPTEC TERT1 [nTPM]":"297.5","Cell RNA - RT4 [nTPM]":"404.1","Cell RNA - SCLC-21H [nTPM]":"184.1","Cell RNA - SH-SY5Y [nTPM]":"216.7","Cell RNA - SiHa [nTPM]":"188.3","Cell RNA - SK-BR-3 [nTPM]":"122.9","Cell RNA - SK-MEL-30 [nTPM]":"180.4","Cell RNA - SuSa [nTPM]":"270.5","Cell RNA - T-47d [nTPM]":"290.3","Cell RNA - THP-1 [nTPM]":"142.3","Cell RNA - TIME [nTPM]":"385.6","Cell RNA - U-138 MG [nTPM]":"492.4","Cell RNA - U-2 OS [nTPM]":"287.9","Cell RNA - U-2197 [nTPM]":"237.0","Cell RNA - U-251 MG [nTPM]":"317.8","Cell RNA - U-266\/70 [nTPM]":"213.3","Cell RNA - U-266\/84 [nTPM]":"320.3","Cell RNA - U-698 [nTPM]":"181.4","Cell RNA - U-87 MG [nTPM]":"357.7","Cell RNA - U-937 [nTPM]":"151.6","Cell RNA - WM-115 [nTPM]":"305.3","Blood RNA - basophil [nTPM]":"16.6","Blood RNA - classical monocyte [nTPM]":"33.1","Blood RNA - eosinophil [nTPM]":"21.3","Blood RNA - gdT-cell [nTPM]":"17.5","Blood RNA - intermediate monocyte [nTPM]":"36.3","Blood RNA - MAIT T-cell [nTPM]":"21.7","Blood RNA - memory B-cell [nTPM]":"13.7","Blood RNA - memory CD4 T-cell [nTPM]":"16.1","Blood RNA - memory CD8 T-cell [nTPM]":"19.2","Blood RNA - myeloid DC [nTPM]":"36.5","Blood RNA - naive B-cell [nTPM]":"12.9","Blood RNA - naive CD4 T-cell [nTPM]":"13.4","Blood RNA - naive CD8 T-cell [nTPM]":"15.0","Blood RNA - neutrophil [nTPM]":"19.9","Blood RNA - NK-cell [nTPM]":"18.9","Blood RNA - non-classical monocyte [nTPM]":"32.5","Blood RNA - plasmacytoid DC [nTPM]":"22.8","Blood RNA - T-reg [nTPM]":"22.1","Blood RNA - total PBMC [nTPM]":"23.3","Brain RNA - amygdala [nTPM]":"42.1","Brain RNA - basal ganglia [nTPM]":"54.9","Brain RNA - cerebellum [nTPM]":"67.3","Brain RNA - cerebral cortex [nTPM]":"103.9","Brain RNA - hippocampal formation [nTPM]":"60.7","Brain RNA - hypothalamus [nTPM]":"65.1","Brain RNA - medulla oblongata [nTPM]":"95.5","Brain RNA - midbrain [nTPM]":"52.4","Brain RNA - pons [nTPM]":"95.2","Brain RNA - spinal cord [nTPM]":"43.8","Brain RNA - thalamus [nTPM]":"68.2","Brain RNA - white matter [nTPM]":"55.0","Single Cell Type RNA - Adipocytes [nTPM]":"62.6","Single Cell Type RNA - Alveolar cells type 1 [nTPM]":"99.3","Single Cell Type RNA - Alveolar cells type 2 [nTPM]":"107.9","Single Cell Type RNA - Astrocytes [nTPM]":"80.3","Single Cell Type RNA - B-cells [nTPM]":"46.3","Single Cell Type RNA - Basal keratinocytes [nTPM]":"63.9","Single Cell Type RNA - Basal prostatic cells [nTPM]":"44.4","Single Cell Type RNA - Basal respiratory cells [nTPM]":"75.6","Single Cell Type RNA - Basal squamous epithelial cells [nTPM]":"28.5","Single Cell Type RNA - Bipolar cells [nTPM]":"91.9","Single Cell Type RNA - Breast glandular cells [nTPM]":"58.5","Single Cell Type RNA - Breast myoepithelial cells [nTPM]":"34.7","Single Cell Type RNA - Cardiomyocytes [nTPM]":"77.9","Single Cell Type RNA - Cholangiocytes [nTPM]":"71.4","Single Cell Type RNA - Club cells [nTPM]":"103.3","Single Cell Type RNA - Collecting duct cells [nTPM]":"77.3","Single Cell Type RNA - Cone photoreceptor cells [nTPM]":"60.5","Single Cell Type RNA - Cytotrophoblasts [nTPM]":"109.1","Single Cell Type RNA - dendritic cells [nTPM]":"60.7","Single Cell Type RNA - Distal enterocytes [nTPM]":"184.0","Single Cell Type RNA - Distal tubular cells [nTPM]":"27.4","Single Cell Type RNA - Ductal cells [nTPM]":"76.2","Single Cell Type RNA - Early spermatids [nTPM]":"23.3","Single Cell Type RNA - Endometrial ciliated cells [nTPM]":"95.5","Single Cell Type RNA - Endometrial stromal cells [nTPM]":"95.6","Single Cell Type RNA - Endothelial cells [nTPM]":"79.7","Single Cell Type RNA - Enteroendocrine cells [nTPM]":"120.6","Single Cell Type RNA - Erythroid cells [nTPM]":"115.9","Single Cell Type RNA - Excitatory neurons [nTPM]":"137.7","Single Cell Type RNA - Exocrine glandular cells [nTPM]":"97.7","Single Cell Type RNA - Extravillous trophoblasts [nTPM]":"47.7","Single Cell Type RNA - Fibroblasts [nTPM]":"84.5","Single Cell Type RNA - Gastric mucus-secreting cells [nTPM]":"99.4","Single Cell Type RNA - Glandular and luminal cells [nTPM]":"106.1","Single Cell Type RNA - granulocytes [nTPM]":"68.4","Single Cell Type RNA - Granulosa cells [nTPM]":"75.5","Single Cell Type RNA - Hepatic stellate cells [nTPM]":"120.7","Single Cell Type RNA - Hepatocytes [nTPM]":"185.4","Single Cell Type RNA - Hofbauer cells [nTPM]":"182.5","Single Cell Type RNA - Horizontal cells [nTPM]":"85.8","Single Cell Type RNA - Inhibitory neurons [nTPM]":"135.9","Single Cell Type RNA - Intestinal goblet cells [nTPM]":"120.7","Single Cell Type RNA - Ionocytes [nTPM]":"77.3","Single Cell Type RNA - Kupffer cells [nTPM]":"195.0","Single Cell Type RNA - Langerhans cells [nTPM]":"93.2","Single Cell Type RNA - Late spermatids [nTPM]":"77.2","Single Cell Type RNA - Leydig cells [nTPM]":"74.0","Single Cell Type RNA - Macrophages [nTPM]":"128.3","Single Cell Type RNA - Melanocytes [nTPM]":"53.4","Single Cell Type RNA - Microglial cells [nTPM]":"79.6","Single Cell Type RNA - monocytes [nTPM]":"102.8","Single Cell Type RNA - Muller glia cells [nTPM]":"53.9","Single Cell Type RNA - NK-cells [nTPM]":"38.1","Single Cell Type RNA - Oligodendrocyte precursor cells [nTPM]":"73.4","Single Cell Type RNA - Oligodendrocytes [nTPM]":"124.2","Single Cell Type RNA - Pancreatic endocrine cells [nTPM]":"106.2","Single Cell Type RNA - Paneth cells [nTPM]":"76.1","Single Cell Type RNA - Peritubular cells [nTPM]":"93.6","Single Cell Type RNA - Plasma cells [nTPM]":"83.0","Single Cell Type RNA - Prostatic glandular cells [nTPM]":"86.3","Single Cell Type RNA - Proximal enterocytes [nTPM]":"102.7","Single Cell Type RNA - Proximal tubular cells [nTPM]":"132.4","Single Cell Type RNA - Respiratory ciliated cells [nTPM]":"128.0","Single Cell Type RNA - Rod photoreceptor cells [nTPM]":"65.2","Single Cell Type RNA - Sertoli cells [nTPM]":"78.9","Single Cell Type RNA - Skeletal myocytes [nTPM]":"66.0","Single Cell Type RNA - Smooth muscle cells [nTPM]":"82.8","Single Cell Type RNA - Spermatocytes [nTPM]":"52.7","Single Cell Type RNA - Spermatogonia [nTPM]":"38.0","Single Cell Type RNA - Squamous epithelial cells [nTPM]":"60.5","Single Cell Type RNA - Suprabasal keratinocytes [nTPM]":"79.3","Single Cell Type RNA - Syncytiotrophoblasts [nTPM]":"107.9","Single Cell Type RNA - T-cells [nTPM]":"45.9","Single Cell Type RNA - Theca cells [nTPM]":"81.3","Single Cell Type RNA - Undifferentiated cells [nTPM]":"127.8","Single Cell Type RNA - Urothelial cells [nTPM]":"91.6"}]