[{"Gene":"RNF4","Gene synonym":["RES4-26","SLX5","SNURF"],"Ensembl":"ENSG00000063978","Gene description":"Ring finger protein 4","Uniprot":["P78317"],"Chromosome":"4","Position":"2462220-2625320","Protein class":["Enzymes","Predicted intracellular proteins"],"Biological process":["Transcription","Transcription regulation","Ubl conjugation pathway"],"Molecular function":["Activator","DNA-binding","Transferase"],"Disease involvement":null,"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Low tissue specificity","RNA tissue distribution":"Detected in all","RNA tissue specificity score":null,"RNA tissue specific nTPM":null,"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in all","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Low immune cell specificity","RNA blood cell distribution":"Detected in all","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Low lineage specificity","RNA blood lineage distribution":"Detected in all","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cell line specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["HPA022047","HPA049356"],"Reliability (IH)":"Approved","Reliability (Mouse Brain)":null,"Reliability (IF)":"Supported","Subcellular location":["Nucleoplasm","Nuclear bodies","Microtubule ends"],"Secretome location":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 27: Non-specific - Gene expression","Tissue expression cluster":"Cluster 66: Lymphoid tissue - Immune response regulation","Cell line expression cluster":"Cluster 16: U-266 - Nucleosome","Single cell expression cluster":"Cluster 59: Non-specific - Transcription","Subcellular main location":["Nucleoplasm","Nuclear bodies"],"Subcellular additional location":["Microtubule ends"],"Antibody RRID":{"HPA022047":null,"HPA049356":"AB_2680726"},"Pathology prognostics - Breast cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.38e-3"},"Pathology prognostics - Cervical cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.69e-1"},"Pathology prognostics - Colorectal cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.29e-2"},"Pathology prognostics - Endometrial cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.33e-1"},"Pathology prognostics - Glioma":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.45e-1"},"Pathology prognostics - Head and neck cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"9.31e-3"},"Pathology prognostics - Liver cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"9.03e-3"},"Pathology prognostics - Lung cancer":{"prognostic type":"unfavorable","is_prognostic":true,"p_val":"6.38e-4"},"Pathology prognostics - Melanoma":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.34e-1"},"Pathology prognostics - Ovarian cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.79e-2"},"Pathology prognostics - Pancreatic cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"2.58e-1"},"Pathology prognostics - Prostate cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"5.64e-2"},"Pathology prognostics - Renal cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.93e-2"},"Pathology prognostics - Stomach cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"6.40e-2"},"Pathology prognostics - Testis cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"4.70e-2"},"Pathology prognostics - Thyroid cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"8.67e-2"},"Pathology prognostics - Urothelial cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.54e-1"},"Tissue RNA - adipose tissue [nTPM]":"30.2","Tissue RNA - adrenal gland [nTPM]":"30.9","Tissue RNA - amygdala [nTPM]":"24.0","Tissue RNA - appendix [nTPM]":"36.0","Tissue RNA - basal ganglia [nTPM]":"24.9","Tissue RNA - bone marrow [nTPM]":"46.4","Tissue RNA - breast [nTPM]":"29.2","Tissue RNA - cerebellum [nTPM]":"26.0","Tissue RNA - cerebral cortex [nTPM]":"25.1","Tissue RNA - cervix [nTPM]":"29.4","Tissue RNA - choroid plexus [nTPM]":"26.5","Tissue RNA - colon [nTPM]":"27.9","Tissue RNA - duodenum [nTPM]":"29.0","Tissue RNA - endometrium 1 [nTPM]":"29.5","Tissue RNA - epididymis [nTPM]":"28.3","Tissue RNA - esophagus [nTPM]":"30.7","Tissue RNA - fallopian tube [nTPM]":"28.5","Tissue RNA - gallbladder [nTPM]":"28.3","Tissue RNA - heart muscle [nTPM]":"27.0","Tissue RNA - hippocampal formation [nTPM]":"24.5","Tissue RNA - hypothalamus [nTPM]":"25.5","Tissue RNA - kidney [nTPM]":"32.6","Tissue RNA - liver [nTPM]":"25.9","Tissue RNA - lung [nTPM]":"27.8","Tissue RNA - lymph node [nTPM]":"49.9","Tissue RNA - medulla oblongata [nTPM]":"26.0","Tissue RNA - midbrain [nTPM]":"25.9","Tissue RNA - ovary [nTPM]":"31.0","Tissue RNA - pancreas [nTPM]":"31.2","Tissue RNA - parathyroid gland [nTPM]":"33.6","Tissue RNA - pituitary gland [nTPM]":"26.8","Tissue RNA - placenta [nTPM]":"28.4","Tissue RNA - pons [nTPM]":"25.2","Tissue RNA - prostate [nTPM]":"28.2","Tissue RNA - rectum [nTPM]":"27.4","Tissue RNA - retina [nTPM]":"24.0","Tissue RNA - salivary gland [nTPM]":"28.0","Tissue RNA - seminal vesicle [nTPM]":"28.1","Tissue RNA - skeletal muscle [nTPM]":"27.7","Tissue RNA - skin 1 [nTPM]":"29.7","Tissue RNA - small intestine [nTPM]":"30.4","Tissue RNA - smooth muscle [nTPM]":"33.1","Tissue RNA - spinal cord [nTPM]":"23.9","Tissue RNA - spleen [nTPM]":"40.3","Tissue RNA - stomach 1 [nTPM]":"30.1","Tissue RNA - testis [nTPM]":"31.9","Tissue RNA - thalamus [nTPM]":"26.3","Tissue RNA - thymus [nTPM]":"50.1","Tissue RNA - thyroid gland [nTPM]":"30.7","Tissue RNA - tongue [nTPM]":"23.2","Tissue RNA - tonsil [nTPM]":"50.0","Tissue RNA - urinary bladder [nTPM]":"35.0","Tissue RNA - vagina [nTPM]":"26.8","Tissue RNA - white matter [nTPM]":"25.5","Cell RNA - A-431 [nTPM]":"60.9","Cell RNA - A549 [nTPM]":"57.0","Cell RNA - AF22 [nTPM]":"57.9","Cell RNA - AN3-CA [nTPM]":"42.0","Cell RNA - ASC diff [nTPM]":"50.6","Cell RNA - ASC TERT1 [nTPM]":"52.2","Cell RNA - BEWO [nTPM]":"65.6","Cell RNA - BJ [nTPM]":"73.3","Cell RNA - BJ hTERT+ [nTPM]":"83.4","Cell RNA - BJ hTERT+ SV40 Large T+ [nTPM]":"77.3","Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [nTPM]":"70.0","Cell RNA - CACO-2 [nTPM]":"65.1","Cell RNA - CAPAN-2 [nTPM]":"56.8","Cell RNA - Daudi [nTPM]":"77.6","Cell RNA - EFO-21 [nTPM]":"42.0","Cell RNA - fHDF\/TERT166 [nTPM]":"76.0","Cell RNA - GAMG [nTPM]":"101.5","Cell RNA - HaCaT [nTPM]":"39.7","Cell RNA - HAP1 [nTPM]":"63.5","Cell RNA - HBEC3-KT [nTPM]":"58.6","Cell RNA - HBF TERT88 [nTPM]":"72.7","Cell RNA - HDLM-2 [nTPM]":"37.6","Cell RNA - HEK 293 [nTPM]":"38.5","Cell RNA - HEL [nTPM]":"92.4","Cell RNA - HeLa [nTPM]":"54.6","Cell RNA - Hep G2 [nTPM]":"62.6","Cell RNA - HHSteC [nTPM]":"76.6","Cell RNA - HL-60 [nTPM]":"66.7","Cell RNA - HMC-1 [nTPM]":"77.8","Cell RNA - HSkMC [nTPM]":"61.0","Cell RNA - hTCEpi [nTPM]":"69.7","Cell RNA - hTEC\/SVTERT24-B [nTPM]":"72.3","Cell RNA - hTERT-HME1 [nTPM]":"59.4","Cell RNA - hTERT-RPE1 [nTPM]":"53.6","Cell RNA - HUVEC TERT2 [nTPM]":"73.1","Cell RNA - JURKAT [nTPM]":"64.8","Cell RNA - K-562 [nTPM]":"50.0","Cell RNA - Karpas-707 [nTPM]":"103.2","Cell RNA - LHCN-M2 [nTPM]":"80.4","Cell RNA - MCF7 [nTPM]":"43.5","Cell RNA - MOLT-4 [nTPM]":"105.0","Cell RNA - NB-4 [nTPM]":"92.5","Cell RNA - NTERA-2 [nTPM]":"89.8","Cell RNA - OE19 [nTPM]":"52.3","Cell RNA - PC-3 [nTPM]":"70.9","Cell RNA - REH [nTPM]":"76.6","Cell RNA - RH-30 [nTPM]":"55.3","Cell RNA - RPMI-8226 [nTPM]":"40.8","Cell RNA - RPTEC TERT1 [nTPM]":"52.6","Cell RNA - RT4 [nTPM]":"74.5","Cell RNA - SCLC-21H [nTPM]":"54.3","Cell RNA - SH-SY5Y [nTPM]":"51.0","Cell RNA - SiHa [nTPM]":"50.5","Cell RNA - SK-BR-3 [nTPM]":"40.4","Cell RNA - SK-MEL-30 [nTPM]":"52.1","Cell RNA - SuSa [nTPM]":"62.9","Cell RNA - T-47d [nTPM]":"63.1","Cell RNA - THP-1 [nTPM]":"50.6","Cell RNA - TIME [nTPM]":"60.0","Cell RNA - U-138 MG [nTPM]":"65.8","Cell RNA - U-2 OS [nTPM]":"32.0","Cell RNA - U-2197 [nTPM]":"64.2","Cell RNA - U-251 MG [nTPM]":"115.4","Cell RNA - U-266\/70 [nTPM]":"131.3","Cell RNA - U-266\/84 [nTPM]":"189.5","Cell RNA - U-698 [nTPM]":"82.6","Cell RNA - U-87 MG [nTPM]":"64.6","Cell RNA - U-937 [nTPM]":"72.7","Cell RNA - WM-115 [nTPM]":"69.5","Blood RNA - basophil [nTPM]":"44.7","Blood RNA - classical monocyte [nTPM]":"70.0","Blood RNA - eosinophil [nTPM]":"104.6","Blood RNA - gdT-cell [nTPM]":"97.7","Blood RNA - intermediate monocyte [nTPM]":"95.4","Blood RNA - MAIT T-cell [nTPM]":"97.2","Blood RNA - memory B-cell [nTPM]":"85.0","Blood RNA - memory CD4 T-cell [nTPM]":"82.2","Blood RNA - memory CD8 T-cell [nTPM]":"97.0","Blood RNA - myeloid DC [nTPM]":"84.1","Blood RNA - naive B-cell [nTPM]":"59.1","Blood RNA - naive CD4 T-cell [nTPM]":"78.8","Blood RNA - naive CD8 T-cell [nTPM]":"80.3","Blood RNA - neutrophil [nTPM]":"77.2","Blood RNA - NK-cell [nTPM]":"99.2","Blood RNA - non-classical monocyte [nTPM]":"103.8","Blood RNA - plasmacytoid DC [nTPM]":"56.5","Blood RNA - T-reg [nTPM]":"98.8","Blood RNA - total PBMC [nTPM]":"128.6","Brain RNA - amygdala [nTPM]":"24.0","Brain RNA - basal ganglia [nTPM]":"24.9","Brain RNA - cerebellum [nTPM]":"26.0","Brain RNA - cerebral cortex [nTPM]":"25.1","Brain RNA - hippocampal formation [nTPM]":"24.5","Brain RNA - hypothalamus [nTPM]":"25.5","Brain RNA - medulla oblongata [nTPM]":"26.0","Brain RNA - midbrain [nTPM]":"25.9","Brain RNA - pons [nTPM]":"25.2","Brain RNA - spinal cord [nTPM]":"23.9","Brain RNA - thalamus [nTPM]":"26.3","Brain RNA - white matter [nTPM]":"25.5","Single Cell Type RNA - Adipocytes [nTPM]":"31.1","Single Cell Type RNA - Alveolar cells type 1 [nTPM]":"22.4","Single Cell Type RNA - Alveolar cells type 2 [nTPM]":"17.5","Single Cell Type RNA - Astrocytes [nTPM]":"17.0","Single Cell Type RNA - B-cells [nTPM]":"36.0","Single Cell Type RNA - Basal keratinocytes [nTPM]":"27.5","Single Cell Type RNA - Basal prostatic cells [nTPM]":"18.4","Single Cell Type RNA - Basal respiratory cells [nTPM]":"17.7","Single Cell Type RNA - Basal squamous epithelial cells [nTPM]":"31.3","Single Cell Type RNA - Bipolar cells [nTPM]":"11.9","Single Cell Type RNA - Breast glandular cells [nTPM]":"24.0","Single Cell Type RNA - Breast myoepithelial cells [nTPM]":"16.0","Single Cell Type RNA - Cardiomyocytes [nTPM]":"20.7","Single Cell Type RNA - Cholangiocytes [nTPM]":"12.8","Single Cell Type RNA - Club cells [nTPM]":"21.3","Single Cell Type RNA - Collecting duct cells [nTPM]":"22.0","Single Cell Type RNA - Cone photoreceptor cells [nTPM]":"16.7","Single Cell Type RNA - Cytotrophoblasts [nTPM]":"21.3","Single Cell Type RNA - dendritic cells [nTPM]":"45.9","Single Cell Type RNA - Distal enterocytes [nTPM]":"16.5","Single Cell Type RNA - Distal tubular cells [nTPM]":"21.5","Single Cell Type RNA - Ductal cells [nTPM]":"22.2","Single Cell Type RNA - Early spermatids [nTPM]":"14.0","Single Cell Type RNA - Endometrial ciliated cells [nTPM]":"17.0","Single Cell Type RNA - Endometrial stromal cells [nTPM]":"22.8","Single Cell Type RNA - Endothelial cells [nTPM]":"21.7","Single Cell Type RNA - Enteroendocrine cells [nTPM]":"12.1","Single Cell Type RNA - Erythroid cells [nTPM]":"15.4","Single Cell Type RNA - Excitatory neurons [nTPM]":"15.9","Single Cell Type RNA - Exocrine glandular cells [nTPM]":"23.3","Single Cell Type RNA - Extravillous trophoblasts [nTPM]":"35.0","Single Cell Type RNA - Fibroblasts [nTPM]":"19.5","Single Cell Type RNA - Gastric mucus-secreting cells [nTPM]":"23.0","Single Cell Type RNA - Glandular and luminal cells [nTPM]":"23.9","Single Cell Type RNA - granulocytes [nTPM]":"14.5","Single Cell Type RNA - Granulosa cells [nTPM]":"22.7","Single Cell Type RNA - Hepatic stellate cells [nTPM]":"16.4","Single Cell Type RNA - Hepatocytes [nTPM]":"20.4","Single Cell Type RNA - Hofbauer cells [nTPM]":"19.7","Single Cell Type RNA - Horizontal cells [nTPM]":"13.5","Single Cell Type RNA - Inhibitory neurons [nTPM]":"17.8","Single Cell Type RNA - Intestinal goblet cells [nTPM]":"16.8","Single Cell Type RNA - Ionocytes [nTPM]":"8.2","Single Cell Type RNA - Kupffer cells [nTPM]":"34.0","Single Cell Type RNA - Langerhans cells [nTPM]":"28.5","Single Cell Type RNA - Late spermatids [nTPM]":"22.4","Single Cell Type RNA - Leydig cells [nTPM]":"17.1","Single Cell Type RNA - Macrophages [nTPM]":"27.8","Single Cell Type RNA - Melanocytes [nTPM]":"7.2","Single Cell Type RNA - Microglial cells [nTPM]":"18.7","Single Cell Type RNA - monocytes [nTPM]":"35.1","Single Cell Type RNA - Muller glia cells [nTPM]":"11.5","Single Cell Type RNA - NK-cells [nTPM]":"43.3","Single Cell Type RNA - Oligodendrocyte precursor cells [nTPM]":"13.0","Single Cell Type RNA - Oligodendrocytes [nTPM]":"16.3","Single Cell Type RNA - Pancreatic endocrine cells [nTPM]":"29.8","Single Cell Type RNA - Paneth cells [nTPM]":"14.3","Single Cell Type RNA - Peritubular cells [nTPM]":"20.7","Single Cell Type RNA - Plasma cells [nTPM]":"47.8","Single Cell Type RNA - Prostatic glandular cells [nTPM]":"27.1","Single Cell Type RNA - Proximal enterocytes [nTPM]":"23.1","Single Cell Type RNA - Proximal tubular cells [nTPM]":"21.2","Single Cell Type RNA - Respiratory ciliated cells [nTPM]":"17.6","Single Cell Type RNA - Rod photoreceptor cells [nTPM]":"17.7","Single Cell Type RNA - Sertoli cells [nTPM]":"26.3","Single Cell Type RNA - Skeletal myocytes [nTPM]":"18.2","Single Cell Type RNA - Smooth muscle cells [nTPM]":"22.0","Single Cell Type RNA - Spermatocytes [nTPM]":"31.2","Single Cell Type RNA - Spermatogonia [nTPM]":"48.6","Single Cell Type RNA - Squamous epithelial cells [nTPM]":"27.0","Single Cell Type RNA - Suprabasal keratinocytes [nTPM]":"32.1","Single Cell Type RNA - Syncytiotrophoblasts [nTPM]":"21.8","Single Cell Type RNA - T-cells [nTPM]":"39.7","Single Cell Type RNA - Theca cells [nTPM]":"16.4","Single Cell Type RNA - Undifferentiated cells [nTPM]":"18.9","Single Cell Type RNA - Urothelial cells [nTPM]":"32.9"}]