[{"Gene":"SCRIB","Gene synonym":["KIAA0147","SCRB1","Vartul"],"Ensembl":"ENSG00000180900","Gene description":"Scribble planar cell polarity protein","Uniprot":["Q14160"],"Chromosome":"8","Position":"143790920-143815773","Protein class":["Disease related genes","Predicted intracellular proteins"],"Biological process":["Differentiation","Host-virus interaction","Inhibition of host innate immune response by virus","Inhibition of host interferon signaling pathway by virus","Inhibition of host STAT1 by virus","Inhibition of host STAT2 by virus","Viral immunoevasion"],"Molecular function":["Developmental protein"],"Disease involvement":["Disease variant"],"Evidence":"Evidence at protein level","HPA evidence":"Evidence at protein level","UniProt evidence":"Evidence at protein level","NeXtProt evidence":"Evidence at protein level","RNA tissue specificity":"Tissue enhanced","RNA tissue distribution":"Detected in many","RNA tissue specificity score":null,"RNA tissue specific nTPM":{"esophagus":"100.5"},"RNA single cell type specificity":"Low cell type specificity","RNA single cell type distribution":"Detected in many","RNA single cell type specificity score":null,"RNA single cell type specific nTPM":null,"RNA cancer specificity":"Low cancer specificity","RNA cancer distribution":"Detected in all","RNA cancer specificity score":null,"RNA cancer specific FPKM":null,"RNA brain regional specificity":"Low region specificity","RNA brain regional distribution":"Detected in all","RNA brain regional specificity score":null,"RNA brain regional specific nTPM":null,"RNA blood cell specificity":"Not detected in immune cells","RNA blood cell distribution":"Not detected","RNA blood cell specificity score":null,"RNA blood cell specific nTPM":null,"RNA blood lineage specificity":"Not detected","RNA blood lineage distribution":"Not detected","RNA blood lineage specificity score":null,"RNA blood lineage specific nTPM":null,"RNA cell line specificity":"Low cell line specificity","RNA cell line distribution":"Detected in all","RNA cell line specificity score":null,"RNA cell line specific nTPM":null,"RNA mouse brain regional specificity":"Low region specificity","RNA mouse brain regional distribution":"Detected in all","RNA mouse brain regional specificity score":null,"RNA mouse brain regional specific nTPM":null,"RNA pig brain regional specificity":"Low region specificity","RNA pig brain regional distribution":"Detected in all","RNA pig brain regional specificity score":null,"RNA pig brain regional specific nTPM":null,"Antibody":["CAB015463","CAB022081","HPA023557","HPA064312"],"Reliability (IH)":"Supported","Reliability (Mouse Brain)":null,"Reliability (IF)":"Enhanced","Subcellular location":["Nucleoplasm","Plasma membrane","Cell Junctions","Rods & Rings"],"Secretome location":null,"CCD Protein":"NA","CCD Transcript":"NA","Blood concentration - Conc. blood IM [pg\/L]":null,"Blood concentration - Conc. blood MS [pg\/L]":null,"Blood expression cluster":"Cluster 16: MAIT-cells - Unknown function","Tissue expression cluster":"Cluster 11: Squamous epithelial cells - Epithelial cell function","Cell line expression cluster":"Cluster 40: Non-specific - Basic cellular processes","Single cell expression cluster":"Cluster 53: Intestinal epithelial cells - Unknown function","Subcellular main location":["Plasma membrane","Cell Junctions"],"Subcellular additional location":["Nucleoplasm","Rods & Rings"],"Antibody RRID":{"CAB015463":"AB_2238926","CAB022081":null,"HPA023557":"AB_2671238","HPA064312":"AB_2685242"},"Pathology prognostics - Breast cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.24e-1"},"Pathology prognostics - Cervical cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.94e-2"},"Pathology prognostics - Colorectal cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"7.78e-2"},"Pathology prognostics - Endometrial cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.95e-2"},"Pathology prognostics - Glioma":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.77e-1"},"Pathology prognostics - Head and neck cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.96e-2"},"Pathology prognostics - Liver cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.14e-3"},"Pathology prognostics - Lung cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.86e-2"},"Pathology prognostics - Melanoma":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.46e-1"},"Pathology prognostics - Ovarian cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.56e-1"},"Pathology prognostics - Pancreatic cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"8.22e-2"},"Pathology prognostics - Prostate cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.87e-1"},"Pathology prognostics - Renal cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"2.16e-3"},"Pathology prognostics - Stomach cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"3.46e-3"},"Pathology prognostics - Testis cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.99e-1"},"Pathology prognostics - Thyroid cancer":{"prognostic type":"favorable","is_prognostic":false,"p_val":"1.10e-1"},"Pathology prognostics - Urothelial cancer":{"prognostic type":"unfavorable","is_prognostic":false,"p_val":"1.83e-1"},"Tissue RNA - adipose tissue [nTPM]":"18.7","Tissue RNA - adrenal gland [nTPM]":"17.1","Tissue RNA - amygdala [nTPM]":"11.5","Tissue RNA - appendix [nTPM]":"7.2","Tissue RNA - basal ganglia [nTPM]":"10.8","Tissue RNA - bone marrow [nTPM]":"5.6","Tissue RNA - breast [nTPM]":"23.6","Tissue RNA - cerebellum [nTPM]":"6.0","Tissue RNA - cerebral cortex [nTPM]":"10.4","Tissue RNA - cervix [nTPM]":"45.6","Tissue RNA - choroid plexus [nTPM]":"0.0","Tissue RNA - colon [nTPM]":"32.3","Tissue RNA - duodenum [nTPM]":"9.1","Tissue RNA - endometrium 1 [nTPM]":"24.7","Tissue RNA - epididymis [nTPM]":"0.9","Tissue RNA - esophagus [nTPM]":"100.5","Tissue RNA - fallopian tube [nTPM]":"26.0","Tissue RNA - gallbladder [nTPM]":"3.4","Tissue RNA - heart muscle [nTPM]":"24.6","Tissue RNA - hippocampal formation [nTPM]":"8.7","Tissue RNA - hypothalamus [nTPM]":"2.7","Tissue RNA - kidney [nTPM]":"27.7","Tissue RNA - liver [nTPM]":"25.4","Tissue RNA - lung [nTPM]":"21.3","Tissue RNA - lymph node [nTPM]":"4.0","Tissue RNA - medulla oblongata [nTPM]":"10.7","Tissue RNA - midbrain [nTPM]":"8.1","Tissue RNA - ovary [nTPM]":"23.0","Tissue RNA - pancreas [nTPM]":"38.8","Tissue RNA - parathyroid gland [nTPM]":"5.2","Tissue RNA - pituitary gland [nTPM]":"24.8","Tissue RNA - placenta [nTPM]":"5.0","Tissue RNA - pons [nTPM]":"5.9","Tissue RNA - prostate [nTPM]":"28.4","Tissue RNA - rectum [nTPM]":"3.4","Tissue RNA - retina [nTPM]":"1.0","Tissue RNA - salivary gland [nTPM]":"40.2","Tissue RNA - seminal vesicle [nTPM]":"5.2","Tissue RNA - skeletal muscle [nTPM]":"54.3","Tissue RNA - skin 1 [nTPM]":"68.3","Tissue RNA - small intestine [nTPM]":"26.5","Tissue RNA - smooth muscle [nTPM]":"2.0","Tissue RNA - spinal cord [nTPM]":"4.9","Tissue RNA - spleen [nTPM]":"22.9","Tissue RNA - stomach 1 [nTPM]":"30.0","Tissue RNA - testis [nTPM]":"26.4","Tissue RNA - thalamus [nTPM]":"9.0","Tissue RNA - thymus [nTPM]":"3.0","Tissue RNA - thyroid gland [nTPM]":"24.6","Tissue RNA - tongue [nTPM]":"1.7","Tissue RNA - tonsil [nTPM]":"3.9","Tissue RNA - urinary bladder [nTPM]":"27.8","Tissue RNA - vagina [nTPM]":"52.6","Tissue RNA - white matter [nTPM]":"15.3","Cell RNA - A-431 [nTPM]":"55.7","Cell RNA - A549 [nTPM]":"33.1","Cell RNA - AF22 [nTPM]":"12.7","Cell RNA - AN3-CA [nTPM]":"20.5","Cell RNA - ASC diff [nTPM]":"5.1","Cell RNA - ASC TERT1 [nTPM]":"6.9","Cell RNA - BEWO [nTPM]":"33.0","Cell RNA - BJ [nTPM]":"30.9","Cell RNA - BJ hTERT+ [nTPM]":"5.3","Cell RNA - BJ hTERT+ SV40 Large T+ [nTPM]":"11.2","Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [nTPM]":"9.1","Cell RNA - CACO-2 [nTPM]":"15.3","Cell RNA - CAPAN-2 [nTPM]":"29.8","Cell RNA - Daudi [nTPM]":"24.2","Cell RNA - EFO-21 [nTPM]":"39.7","Cell RNA - fHDF\/TERT166 [nTPM]":"7.2","Cell RNA - GAMG [nTPM]":"4.6","Cell RNA - HaCaT [nTPM]":"52.4","Cell RNA - HAP1 [nTPM]":"7.9","Cell RNA - HBEC3-KT [nTPM]":"32.9","Cell RNA - HBF TERT88 [nTPM]":"1.7","Cell RNA - HDLM-2 [nTPM]":"30.8","Cell RNA - HEK 293 [nTPM]":"58.5","Cell RNA - HEL [nTPM]":"24.6","Cell RNA - HeLa [nTPM]":"30.5","Cell RNA - Hep G2 [nTPM]":"26.1","Cell RNA - HHSteC [nTPM]":"10.8","Cell RNA - HL-60 [nTPM]":"13.0","Cell RNA - HMC-1 [nTPM]":"14.8","Cell RNA - HSkMC [nTPM]":"5.1","Cell RNA - hTCEpi [nTPM]":"29.9","Cell RNA - hTEC\/SVTERT24-B [nTPM]":"9.4","Cell RNA - hTERT-HME1 [nTPM]":"5.5","Cell RNA - hTERT-RPE1 [nTPM]":"5.1","Cell RNA - HUVEC TERT2 [nTPM]":"11.5","Cell RNA - JURKAT [nTPM]":"19.8","Cell RNA - K-562 [nTPM]":"42.2","Cell RNA - Karpas-707 [nTPM]":"6.4","Cell RNA - LHCN-M2 [nTPM]":"7.5","Cell RNA - MCF7 [nTPM]":"93.0","Cell RNA - MOLT-4 [nTPM]":"38.1","Cell RNA - NB-4 [nTPM]":"26.9","Cell RNA - NTERA-2 [nTPM]":"15.7","Cell RNA - OE19 [nTPM]":"25.0","Cell RNA - PC-3 [nTPM]":"55.1","Cell RNA - REH [nTPM]":"44.5","Cell RNA - RH-30 [nTPM]":"10.6","Cell RNA - RPMI-8226 [nTPM]":"25.0","Cell RNA - RPTEC TERT1 [nTPM]":"5.6","Cell RNA - RT4 [nTPM]":"45.5","Cell RNA - SCLC-21H [nTPM]":"29.6","Cell RNA - SH-SY5Y [nTPM]":"27.1","Cell RNA - SiHa [nTPM]":"31.4","Cell RNA - SK-BR-3 [nTPM]":"30.5","Cell RNA - SK-MEL-30 [nTPM]":"33.6","Cell RNA - SuSa [nTPM]":"4.5","Cell RNA - T-47d [nTPM]":"41.5","Cell RNA - THP-1 [nTPM]":"28.2","Cell RNA - TIME [nTPM]":"25.7","Cell RNA - U-138 MG [nTPM]":"10.1","Cell RNA - U-2 OS [nTPM]":"64.1","Cell RNA - U-2197 [nTPM]":"25.2","Cell RNA - U-251 MG [nTPM]":"44.7","Cell RNA - U-266\/70 [nTPM]":"31.6","Cell RNA - U-266\/84 [nTPM]":"31.0","Cell RNA - U-698 [nTPM]":"23.8","Cell RNA - U-87 MG [nTPM]":"13.1","Cell RNA - U-937 [nTPM]":"9.5","Cell RNA - WM-115 [nTPM]":"19.5","Blood RNA - basophil [nTPM]":"0.0","Blood RNA - classical monocyte [nTPM]":"0.0","Blood RNA - eosinophil [nTPM]":"0.0","Blood RNA - gdT-cell [nTPM]":"0.0","Blood RNA - intermediate monocyte [nTPM]":"0.0","Blood RNA - MAIT T-cell [nTPM]":"0.2","Blood RNA - memory B-cell [nTPM]":"0.0","Blood RNA - memory CD4 T-cell [nTPM]":"0.0","Blood RNA - memory CD8 T-cell [nTPM]":"0.1","Blood RNA - myeloid DC [nTPM]":"0.1","Blood RNA - naive B-cell [nTPM]":"0.0","Blood RNA - naive CD4 T-cell [nTPM]":"0.0","Blood RNA - naive CD8 T-cell [nTPM]":"0.0","Blood RNA - neutrophil [nTPM]":"0.0","Blood RNA - NK-cell [nTPM]":"0.0","Blood RNA - non-classical monocyte [nTPM]":"0.0","Blood RNA - plasmacytoid DC [nTPM]":"0.0","Blood RNA - T-reg [nTPM]":"0.0","Blood RNA - total PBMC [nTPM]":"0.1","Brain RNA - amygdala [nTPM]":"11.5","Brain RNA - basal ganglia [nTPM]":"10.8","Brain RNA - cerebellum [nTPM]":"6.0","Brain RNA - cerebral cortex [nTPM]":"10.4","Brain RNA - hippocampal formation [nTPM]":"8.7","Brain RNA - hypothalamus [nTPM]":"2.7","Brain RNA - medulla oblongata [nTPM]":"10.7","Brain RNA - midbrain [nTPM]":"8.1","Brain RNA - pons [nTPM]":"5.9","Brain RNA - spinal cord [nTPM]":"4.9","Brain RNA - thalamus [nTPM]":"9.0","Brain RNA - white matter [nTPM]":"15.3","Single Cell Type RNA - Adipocytes [nTPM]":"12.3","Single Cell Type RNA - Alveolar cells type 1 [nTPM]":"0.0","Single Cell Type RNA - Alveolar cells type 2 [nTPM]":"9.9","Single Cell Type RNA - Astrocytes [nTPM]":"33.0","Single Cell Type RNA - B-cells [nTPM]":"4.4","Single Cell Type RNA - Basal keratinocytes [nTPM]":"8.5","Single Cell Type RNA - Basal prostatic cells [nTPM]":"5.0","Single Cell Type RNA - Basal respiratory cells [nTPM]":"10.2","Single Cell Type RNA - Basal squamous epithelial cells [nTPM]":"13.6","Single Cell Type RNA - Bipolar cells [nTPM]":"11.3","Single Cell Type RNA - Breast glandular cells [nTPM]":"16.8","Single Cell Type RNA - Breast myoepithelial cells [nTPM]":"17.0","Single Cell Type RNA - Cardiomyocytes [nTPM]":"11.1","Single Cell Type RNA - Cholangiocytes [nTPM]":"11.5","Single Cell Type RNA - Club cells [nTPM]":"8.3","Single Cell Type RNA - Collecting duct cells [nTPM]":"14.7","Single Cell Type RNA - Cone photoreceptor cells [nTPM]":"14.6","Single Cell Type RNA - Cytotrophoblasts [nTPM]":"11.0","Single Cell Type RNA - dendritic cells [nTPM]":"9.7","Single Cell Type RNA - Distal enterocytes [nTPM]":"28.7","Single Cell Type RNA - Distal tubular cells [nTPM]":"3.9","Single Cell Type RNA - Ductal cells [nTPM]":"8.6","Single Cell Type RNA - Early spermatids [nTPM]":"1.5","Single Cell Type RNA - Endometrial ciliated cells [nTPM]":"14.0","Single Cell Type RNA - Endometrial stromal cells [nTPM]":"7.7","Single Cell Type RNA - Endothelial cells [nTPM]":"7.8","Single Cell Type RNA - Enteroendocrine cells [nTPM]":"13.8","Single Cell Type RNA - Erythroid cells [nTPM]":"13.7","Single Cell Type RNA - Excitatory neurons [nTPM]":"5.0","Single Cell Type RNA - Exocrine glandular cells [nTPM]":"9.4","Single Cell Type RNA - Extravillous trophoblasts [nTPM]":"6.3","Single Cell Type RNA - Fibroblasts [nTPM]":"7.3","Single Cell Type RNA - Gastric mucus-secreting cells [nTPM]":"29.6","Single Cell Type RNA - Glandular and luminal cells [nTPM]":"27.3","Single Cell Type RNA - granulocytes [nTPM]":"0.0","Single Cell Type RNA - Granulosa cells [nTPM]":"17.9","Single Cell Type RNA - Hepatic stellate cells [nTPM]":"3.6","Single Cell Type RNA - Hepatocytes [nTPM]":"8.8","Single Cell Type RNA - Hofbauer cells [nTPM]":"6.5","Single Cell Type RNA - Horizontal cells [nTPM]":"5.0","Single Cell Type RNA - Inhibitory neurons [nTPM]":"6.2","Single Cell Type RNA - Intestinal goblet cells [nTPM]":"17.8","Single Cell Type RNA - Ionocytes [nTPM]":"18.3","Single Cell Type RNA - Kupffer cells [nTPM]":"6.0","Single Cell Type RNA - Langerhans cells [nTPM]":"4.1","Single Cell Type RNA - Late spermatids [nTPM]":"0.7","Single Cell Type RNA - Leydig cells [nTPM]":"9.0","Single Cell Type RNA - Macrophages [nTPM]":"6.6","Single Cell Type RNA - Melanocytes [nTPM]":"8.8","Single Cell Type RNA - Microglial cells [nTPM]":"6.5","Single Cell Type RNA - monocytes [nTPM]":"5.0","Single Cell Type RNA - Muller glia cells [nTPM]":"10.0","Single Cell Type RNA - NK-cells [nTPM]":"5.2","Single Cell Type RNA - Oligodendrocyte precursor cells [nTPM]":"12.1","Single Cell Type RNA - Oligodendrocytes [nTPM]":"15.2","Single Cell Type RNA - Pancreatic endocrine cells [nTPM]":"11.5","Single Cell Type RNA - Paneth cells [nTPM]":"22.8","Single Cell Type RNA - Peritubular cells [nTPM]":"9.8","Single Cell Type RNA - Plasma cells [nTPM]":"5.6","Single Cell Type RNA - Prostatic glandular cells [nTPM]":"9.3","Single Cell Type RNA - Proximal enterocytes [nTPM]":"16.9","Single Cell Type RNA - Proximal tubular cells [nTPM]":"4.5","Single Cell Type RNA - Respiratory ciliated cells [nTPM]":"9.9","Single Cell Type RNA - Rod photoreceptor cells [nTPM]":"16.0","Single Cell Type RNA - Sertoli cells [nTPM]":"13.1","Single Cell Type RNA - Skeletal myocytes [nTPM]":"12.0","Single Cell Type RNA - Smooth muscle cells [nTPM]":"8.7","Single Cell Type RNA - Spermatocytes [nTPM]":"9.4","Single Cell Type RNA - Spermatogonia [nTPM]":"10.0","Single Cell Type RNA - Squamous epithelial cells [nTPM]":"19.9","Single Cell Type RNA - Suprabasal keratinocytes [nTPM]":"10.7","Single Cell Type RNA - Syncytiotrophoblasts [nTPM]":"5.1","Single Cell Type RNA - T-cells [nTPM]":"7.3","Single Cell Type RNA - Theca cells [nTPM]":"8.0","Single Cell Type RNA - Undifferentiated cells [nTPM]":"23.2","Single Cell Type RNA - Urothelial cells [nTPM]":"7.1"}]