Two approaches for large-scale classification of fluorescence microscopy images were used to analyze subcellular protein patterns in images from the HPA Cell Atlas. An image-classification task was introduced into the online science fiction video game, EVE Online. 320,000 gamers provided more than 32 million image classifications, and the data was combined with deep learning to build a tool to classify proteins into 29 subcellular localization patterns.

Key publication

• Sullivan DP et al., Deep learning is combined with massive-scale citizen science to improve large-scale image classification. Nat Biotechnol. (2018)
  PubMed: 30125267 DOI: 10.1038/nbt.4225

Other selected publications

• Peplow M., Citizen science lures gamers into Sweden's Human Protein Atlas. Nat Biotechnol. (2016)
  PubMed: 27153260 DOI: 10.1038/nbt0516-452c