Multiplex immunohistochemistry (mIHC/IF) reveals nuclear expression of the protein Shugoshin 1 (gene: SGO1) in pachytene/diplotene spermatocytes - the early cell states of developing sperm cells...Read more

GDF11, or Growth Differentiation Factor 11, rose to fame as a promising anti-aging molecule in 2013 when repletion in mice was shown to result in an age-related decline and reversal of cardiac hypertrophy (Loffredo, 2013). Subsequent studies further announced abilities to regenerate skeletal muscle and revascularize the brain (Sinha, 2014; Katsimpardi, 2014). In 2022, the biopharmaceutical company Elevian raised $58 million for GDF11 research, prompting a New York Times article titled "Can a 'Magic' Protein Slow the Aging Process?"..Read more

Current approaches to determine molecular signatures of health often rely on samples taken by venous blood draws at health care centers. In a study published in Communications medicine, researchers from KTH, Karolinska Institute, and the University of Gothenburg instead used a home sampling device to collect dried blood spots from the general population during the COVID-19 pandemic...Read more

In a study published in the Journal of the Endocrine Society, transcriptomics analysis and radiological evaluation was used to explore the differences between invasive and noninvasive pituitary neuroendocrine tumors (PitNETs) with respect to parasellar growth, bone invasiveness and vascularization...Read more

Our cells contain tiny molecular clocks that control a multitude of physiological and behavioral processes according to the circadian rhythm. Governed by a central clock, residing in the suprachiasmic nucleus of the brain, peripheral clocks are present in almost all tissues and organs (Hastings et al., 2003). They are, though able to persist in the absence of environmental cues, driven by the 24-hour patterns of light and temperature produced by the earth´s rotation, and periodically regulate functions such as body temperature, blood pressure, circulating hormones and metabolism (Mazzoccoli et al., 2012)...Read more