Immune cell - ZNHIT3 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZNHIT3
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger HIT-type containing 3
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular

IMMUNE CELL SECTION SUMMARY
Immune cell type expression clusterⁱ The RNA data is used to cluster genes according to their expression across immune cells. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Translation (mainly)
Immune cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell type distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Immune cell lineage specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: lineage enriched, group enriched, lineage enhanced, low lineage specificity and not detected. Lineages include B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells. Read more	Low lineage specificity
Immune cell lineage distributionⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Detected in all

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ

HPA datasetⁱ

Lineage

Expression

Alphabetical

Immune cell type specificity: Low immune cell specificity

Monaco datasetⁱ

Lineage

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

ZNHIT3 is part of cluster 30 Non-specific - Translation with confidenceⁱ 0.71
193 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on immune cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ABCE1	ATP binding cassette subfamily E member 1	0.7477	27
ZCCHC14	Zinc finger CCHC-type containing 14	0.6810	16
RFESD	Rieske Fe-S domain containing	0.6779	32
TPT1	Tumor protein, translationally-controlled 1	0.6747	32
TUBE1	Tubulin epsilon 1	0.6592	16
RLN2	Relaxin 2	0.6538	22
NUP35	Nucleoporin 35	0.6534	27
ATAD1	ATPase family AAA domain containing 1	0.6467	44
B3GNT3	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	0.6463	32
TOMM20	Translocase of outer mitochondrial membrane 20	0.6445	44
RPL5	Ribosomal protein L5	0.6432	30
KLHL34	Kelch like family member 34	0.6392	32
RASA2	RAS p21 protein activator 2	0.6360	32
EIF4B	Eukaryotic translation initiation factor 4B	0.6356	32
ST13	ST13 Hsp70 interacting protein	0.6338	44