Immune cell - NUDT18 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NUDT18
Gene descriptionⁱ Full gene name according to HGNC.	Nudix hydrolase 18
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular

IMMUNE CELL SECTION SUMMARY
Immune cell type expression clusterⁱ The RNA data is used to cluster genes according to their expression across immune cells. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Eosinophils - Transcription (mainly)
Immune cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell type distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Immune cell lineage specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: lineage enriched, group enriched, lineage enhanced, low lineage specificity and not detected. Lineages include B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells. Read more	Low lineage specificity
Immune cell lineage distributionⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Detected in all

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ

HPA datasetⁱ

Lineage

Expression

Alphabetical

Immune cell type specificity: Low immune cell specificity

Monaco datasetⁱ

Lineage

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

NUDT18 is part of cluster 52 Eosinophils - Transcription with confidenceⁱ 1
439 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on immune cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
REXO4	REX4 homolog, 3'-5' exonuclease	0.8581	26
CEP104	Centrosomal protein 104	0.8091	52
TXNDC11	Thioredoxin domain containing 11	0.7815	26
MTA1	Metastasis associated 1	0.7615	52
DNAJB2	DnaJ heat shock protein family (Hsp40) member B2	0.7504	52
MOB3C	MOB kinase activator 3C	0.7468	26
DEXI	Dexi homolog	0.7357	52
DOT1L	DOT1 like histone lysine methyltransferase	0.7268	52
BLOC1S4	Biogenesis of lysosomal organelles complex 1 subunit 4	0.7219	52
CTNNBIP1	Catenin beta interacting protein 1	0.7170	52
SYCE2	Synaptonemal complex central element protein 2	0.7166	15
SLC52A2	Solute carrier family 52 member 2	0.7028	52
OVOL3	Ovo like zinc finger 3	0.7010	52
CCDC85B	Coiled-coil domain containing 85B	0.7001	26
TMEM102	Transmembrane protein 102	0.6961	52