Immune cell - H3C10 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	H3C10
Gene descriptionⁱ Full gene name according to HGNC.	H3 clustered histone 10
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular

IMMUNE CELL SECTION SUMMARY
Immune cell type expression clusterⁱ The RNA data is used to cluster genes according to their expression across immune cells. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Basophils - Unknown function (mainly)
Immune cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (basophil, neutrophil)
Immune cell type distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Immune cell lineage specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: lineage enriched, group enriched, lineage enhanced, low lineage specificity and not detected. Lineages include B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells. Read more	Lineage enriched (granulocytes)
Immune cell lineage distributionⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Detected in all

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ

HPA datasetⁱ

Lineage

Expression

Alphabetical

Immune cell type specificity: Group enriched (basophil, neutrophil)

Monaco datasetⁱ

Lineage

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

H3C10 is part of cluster 34 Basophils - Unknown function with confidenceⁱ 1
261 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on immune cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SH3BGRL2	SH3 domain binding glutamate rich protein like 2	0.9720	34
ITGB3	Integrin subunit beta 3	0.9693	34
PPBP	Pro-platelet basic protein	0.9631	34
SCGB1C1	Secretoglobin family 1C member 1	0.9617	34
TUBB1	Tubulin beta 1 class VI	0.9613	34
TREML1	Triggering receptor expressed on myeloid cells like 1	0.9608	34
CAVIN2	Caveolae associated protein 2	0.9577	34
GP9	Glycoprotein IX platelet	0.9551	34
CMTM5	CKLF like MARVEL transmembrane domain containing 5	0.9546	34
GP1BA	Glycoprotein Ib platelet subunit alpha	0.9497	34
PF4	Platelet factor 4	0.9493	34
CDH20	Cadherin 20	0.9444	34
PF4V1	Platelet factor 4 variant 1	0.9368	34
FSTL1	Follistatin like 1	0.9293	34
PARD3	Par-3 family cell polarity regulator	0.9257	34