Immune cell - IGHV5-10-1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IGHV5-10-1
Gene descriptionⁱ Full gene name according to HGNC.	Immunoglobulin heavy variable 5-10-1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Secreted

IMMUNE CELL SECTION SUMMARY
Immune cell type expression clusterⁱ The RNA data is used to cluster genes according to their expression across immune cells. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	B-cells - Humoral immune response (mainly)
Immune cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (memory B-cell, naive B-cell)
Immune cell type distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Immune cell lineage specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: lineage enriched, group enriched, lineage enhanced, low lineage specificity and not detected. Lineages include B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells. Read more	Lineage enriched (B-cells)
Immune cell lineage distributionⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Detected in many

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ

HPA datasetⁱ

Lineage

Expression

Alphabetical

Immune cell type specificity: Group enriched (memory B-cell, naive B-cell)

Monaco datasetⁱ

Lineage

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

IGHV5-10-1 is part of cluster 43 B-cells - Humoral immune response with confidenceⁱ 1
204 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on immune cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
IGHV4-4	Immunoglobulin heavy variable 4-4	0.9408	43
IGHV2-70	Immunoglobulin heavy variable 2-70	0.9288	43
IGHV3-11	Immunoglobulin heavy variable 3-11	0.9279	43
IGHV3-64D	Immunoglobulin heavy variable 3-64D	0.9266	43
EBF1	EBF transcription factor 1	0.9190	43
IGHV3-49	Immunoglobulin heavy variable 3-49	0.9155	43
IGHV4-59	Immunoglobulin heavy variable 4-59	0.9115	43
IGHV1-3	Immunoglobulin heavy variable 1-3	0.9106	43
IGHV3-20	Immunoglobulin heavy variable 3-20	0.9066	43
IGHV4-31	Immunoglobulin heavy variable 4-31	0.9030	43
IGKV1D-12	Immunoglobulin kappa variable 1D-12	0.8968	43
IGHV3-53	Immunoglobulin heavy variable 3-53	0.8928	43
IGHV2-70D	Immunoglobulin heavy variable 2-70D	0.8914	43
UCHL1	Ubiquitin C-terminal hydrolase L1	0.8901	43
IGHV2-5	Immunoglobulin heavy variable 2-5	0.8870	43