Immune cell - TEX52 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TEX52
Gene descriptionⁱ Full gene name according to HGNC.	Testis expressed 52
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular

IMMUNE CELL SECTION SUMMARY
Immune cell type expression clusterⁱ The RNA data is used to cluster genes according to their expression across immune cells. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	NK-cells - Transcription (mainly)
Immune cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enriched (NK-cell)
Immune cell type distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Immune cell lineage specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: lineage enriched, group enriched, lineage enhanced, low lineage specificity and not detected. Lineages include B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells. Read more	Lineage enriched (NK-cells)
Immune cell lineage distributionⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Detected in single

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ

HPA datasetⁱ

Lineage

Expression

Alphabetical

Immune cell type specificity: Immune cell enriched (NK-cell)

Monaco datasetⁱ

Lineage

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

TEX52 is part of cluster 15 NK-cells - Transcription with confidenceⁱ 1
429 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on immune cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CACNA1C	Calcium voltage-gated channel subunit alpha1 C	0.9947	15
CHRNG	Cholinergic receptor nicotinic gamma subunit	0.9933	15
SAMD11	Sterile alpha motif domain containing 11	0.9929	15
C12orf71	Chromosome 12 open reading frame 71	0.9884	15
NR1I2	Nuclear receptor subfamily 1 group I member 2	0.9831	15
AC004223.3	RAD51L3-RFFL readthrough	0.9773	15
DNAI2	Dynein axonemal intermediate chain 2	0.9773	15
GOLGA8Q	Golgin A8 family member Q	0.9755	15
SALL4	Spalt like transcription factor 4	0.9711	15
ADAMTS16	ADAM metallopeptidase with thrombospondin type 1 motif 16	0.9680	15
MAP3K21	Mitogen-activated protein kinase kinase kinase 21	0.9648	15
PRRT2	Proline rich transmembrane protein 2	0.9604	15
SFT2D3	SFT2 domain containing 3	0.9568	15
DNA2	DNA replication helicase/nuclease 2	0.9364	15
ZNF229	Zinc finger protein 229	0.9324	15