Cell line - R3HDM1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	R3HDM1
Gene descriptionⁱ Full gene name according to HGNC.	R3H domain containing 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	JURKAT & MOLT-4 - Adaptive immune response (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

R3HDM1 is part of cluster 22 JURKAT & MOLT-4 - Adaptive immune response with confidenceⁱ 1
459 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
USP7	Ubiquitin specific peptidase 7	0.7937	22
TLK1	Tousled like kinase 1	0.7036	26
SEPTIN1	Septin 1	0.6555	22
TAF15	TATA-box binding protein associated factor 15	0.6346	26
SCAI	Suppressor of cancer cell invasion	0.6312	22
KLLN	Killin, p53 regulated DNA replication inhibitor	0.6263	22
ABHD18	Abhydrolase domain containing 18	0.6051	22
SHQ1	SHQ1, H/ACA ribonucleoprotein assembly factor	0.6040	22
CTCF	CCCTC-binding factor	0.6006	22
TRAJ24	T cell receptor alpha joining 24	0.5949	22
LCK	LCK proto-oncogene, Src family tyrosine kinase	0.5885	22
RHOH	Ras homolog family member H	0.5883	22
TRBJ2-2	T cell receptor beta joining 2-2	0.5836	22
ELP3	Elongator acetyltransferase complex subunit 3	0.5834	22
TTI2	TELO2 interacting protein 2	0.5812	22