Cell line - THOC3 - The Human Protein Atlas

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THOC3

SUMMARY

TISSUE

BRAIN

SINGLE CELL

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PATHOLOGY

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BLOOD

SUBCELL

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METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	THOC3
Gene descriptionⁱ Full gene name according to HGNC.	THO complex 3
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	BEWO - Transcription regulation (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

THOC3 is part of cluster 28 BEWO - Transcription regulation with confidenceⁱ 1
389 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CCNB1	Cyclin B1	0.6929	28
SUV39H1	Suppressor of variegation 3-9 homolog 1	0.6425	26
NR2E1	Nuclear receptor subfamily 2 group E member 1	0.6249	28
GEMIN4	Gem nuclear organelle associated protein 4	0.5684	26
UCP1	Uncoupling protein 1	0.5551	28
HACL1	2-hydroxyacyl-CoA lyase 1	0.5520	28
RPL26L1	Ribosomal protein L26 like 1	0.5516	40
SRP19	Signal recognition particle 19	0.5488	26
CDH1	Cadherin 1	0.5466	28
REEP1	Receptor accessory protein 1	0.5401	28
WRAP53	WD repeat containing antisense to TP53	0.5379	26
RBM22	RNA binding motif protein 22	0.5310	26
GOT2	Glutamic-oxaloacetic transaminase 2	0.5294	26
DDX4	DEAD-box helicase 4	0.5291	28
WDR89	WD repeat domain 89	0.5283	26

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.