Cell line - LAPTM4A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LAPTM4A
Gene descriptionⁱ Full gene name according to HGNC.	Lysosomal protein transmembrane 4 alpha
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Mesenchymal cell lines - ECM organization (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (ASC diff)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

LAPTM4A is part of cluster 34 Mesenchymal cell lines - ECM organization with confidenceⁱ 1
626 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PLAC9	Placenta associated 9	0.8142	34
AOC3	Amine oxidase copper containing 3	0.7949	34
PCK1	Phosphoenolpyruvate carboxykinase 1	0.7854	34
FMO3	Flavin containing dimethylaniline monoxygenase 3	0.7818	34
ACSL1	Acyl-CoA synthetase long chain family member 1	0.7804	34
C14orf180	Chromosome 14 open reading frame 180	0.7798	34
AGTR1	Angiotensin II receptor type 1	0.7796	34
ANGPTL5	Angiopoietin like 5	0.7796	34
ACOX2	Acyl-CoA oxidase 2	0.7775	34
OMD	Osteomodulin	0.7759	34
ADH1B	Alcohol dehydrogenase 1B (class I), beta polypeptide	0.7747	34
CIDEC	Cell death inducing DFFA like effector c	0.7731	34
CNR1	Cannabinoid receptor 1	0.7727	34
PLIN1	Perilipin 1	0.7717	34
THRSP	Thyroid hormone responsive	0.7717	34