Cell line - SMARCA2 - The Human Protein Atlas

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SMARCA2

SUMMARY

TISSUE

BRAIN

SINGLE CELL

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PATHOLOGY

IMMUNE

BLOOD

SUBCELL

CELL LINE

METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SMARCA2
Gene descriptionⁱ Full gene name according to HGNC.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	42

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	HDLM-2 - Immune response (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enriched (HDLM-2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SMARCA2 is part of cluster 44 HDLM-2 - Immune response with confidenceⁱ 1
446 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ACTN3	Actinin alpha 3	0.9366	44
CCR4	C-C motif chemokine receptor 4	0.9126	44
PROB1	Proline rich basic protein 1	0.9105	44
ETV3L	ETS variant transcription factor 3 like	0.9063	44
CCR8	C-C motif chemokine receptor 8	0.9051	44
AKR1C8P	Aldo-keto reductase family 1 member C8, pseudogene	0.9022	44
CLDN14	Claudin 14	0.9018	44
AHCYL2	Adenosylhomocysteinase like 2	0.9016	44
IL2RA	Interleukin 2 receptor subunit alpha	0.9000	44
KRTAP29-1	Keratin associated like protein 29-1	0.8986	44
TRAV34	T cell receptor alpha variable 34	0.8980	44
TRAV26-2	T cell receptor alpha variable 26-2	0.8964	44
TRAJ26	T cell receptor alpha joining 26	0.8964	44
KRTAP4-3	Keratin associated protein 4-3	0.8964	44
KRTAP9-1	Keratin associated protein 9-1	0.8964	44

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.