Cell line - GPR143 - The Human Protein Atlas

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GPR143

SUMMARY

TISSUE

BRAIN

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PATHOLOGY

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METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GPR143
Gene descriptionⁱ Full gene name according to HGNC.	G protein-coupled receptor 143
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes G-protein coupled receptors Human disease related genes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	SK-MEL-30 - Melanocyte processes (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enriched (SK-MEL-30)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

GPR143 is part of cluster 33 SK-MEL-30 - Melanocyte processes with confidenceⁱ 1
391 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RLBP1	Retinaldehyde binding protein 1	0.9415	33
VSTM2B	V-set and transmembrane domain containing 2B	0.9411	33
SLC5A4	Solute carrier family 5 member 4	0.9374	33
PLA1A	Phospholipase A1 member A	0.9368	33
SLC16A6	Solute carrier family 16 member 6	0.9364	33
MLANA	Melan-A	0.9356	33
PMEL	Premelanosome protein	0.9354	33
SPATS1	Spermatogenesis associated serine rich 1	0.9346	33
DCT	Dopachrome tautomerase	0.9342	33
TYR	Tyrosinase	0.9326	33
CPN1	Carboxypeptidase N subunit 1	0.9326	33
ROPN1	Rhophilin associated tail protein 1	0.9326	33
RXRG	Retinoid X receptor gamma	0.9322	33
SLC45A2	Solute carrier family 45 member 2	0.9322	33
SLC24A5	Solute carrier family 24 member 5	0.9318	33

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.