Cell line - KBTBD4 - The Human Protein Atlas

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KBTBD4

SUMMARY

TISSUE

BRAIN

SINGLE CELL

TISSUE CELL

PATHOLOGY

IMMUNE

BLOOD

SUBCELL

CELL LINE

METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	KBTBD4
Gene descriptionⁱ Full gene name according to HGNC.	Kelch repeat and BTB domain containing 4
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Cell cycle regulation (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

KBTBD4 is part of cluster 26 Non-specific - Cell cycle regulation with confidenceⁱ 0.8
1622 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
UBR7	Ubiquitin protein ligase E3 component n-recognin 7	0.6018	26
INIP	INTS3 and NABP interacting protein	0.5713	16
VPS45	Vacuolar protein sorting 45 homolog	0.5587	13
RBM23	RNA binding motif protein 23	0.5470	26
MEGF9	Multiple EGF like domains 9	0.5455	20
SYNJ2BP	Synaptojanin 2 binding protein	0.5362	13
FSD1L	Fibronectin type III and SPRY domain containing 1 like	0.5352	22
AREL1	Apoptosis resistant E3 ubiquitin protein ligase 1	0.5263	19
GDAP1	Ganglioside induced differentiation associated protein 1	0.5164	13
PPP1R13B	Protein phosphatase 1 regulatory subunit 13B	0.5097	14
ARL10	ADP ribosylation factor like GTPase 10	0.5028	12
ZNF510	Zinc finger protein 510	0.5012	31
MOAP1	Modulator of apoptosis 1	0.4964	21
PPP6C	Protein phosphatase 6 catalytic subunit	0.4925	16
ST6GAL1	ST6 beta-galactoside alpha-2,6-sialyltransferase 1	0.4895	29

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.