Cell line - GIMAP6 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GIMAP6
Gene descriptionⁱ Full gene name according to HGNC.	GTPase, IMAP family member 6
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	TIME & HUVEC/TERT2 - Endothelial cell function (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HMC-1, HUVEC TERT2, MOLT-4, TIME)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

GIMAP6 is part of cluster 41 TIME & HUVEC/TERT2 - Endothelial cell function with confidenceⁱ 1
476 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GIMAP1	GTPase, IMAP family member 1	0.9186	41
ICAM2	Intercellular adhesion molecule 2	0.9055	41
GIMAP4	GTPase, IMAP family member 4	0.8917	41
HHIP	Hedgehog interacting protein	0.8899	41
FAM124B	Family with sequence similarity 124 member B	0.8893	41
SHE	Src homology 2 domain containing E	0.8883	41
CCL14	C-C motif chemokine ligand 14	0.8877	41
BMX	BMX non-receptor tyrosine kinase	0.8872	41
EMCN	Endomucin	0.8870	41
VWF	Von Willebrand factor	0.8856	41
DIPK2B	Divergent protein kinase domain 2B	0.8846	41
SNRK	SNF related kinase	0.8826	41
AC007998.2	Novel protein	0.8802	41
LRRC70	Leucine rich repeat containing 70	0.8785	41
PECAM1	Platelet and endothelial cell adhesion molecule 1	0.8711	41