Cell line - ZCCHC14 - The Human Protein Atlas

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ZCCHC14

SUMMARY

TISSUE

BRAIN

SINGLE CELL

TISSUE CELL

PATHOLOGY

IMMUNE

BLOOD

SUBCELL

CELL LINE

METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZCCHC14
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger CCHC-type containing 14
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	SH-SY5Y - Nervous system development (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

ZCCHC14 is part of cluster 13 SH-SY5Y - Nervous system development with confidenceⁱ 1
375 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PCDHB14	Protocadherin beta 14	0.6887	13
CBFA2T2	CBFA2/RUNX1 partner transcriptional co-repressor 2	0.6328	13
HOXC5	Homeobox C5	0.6126	13
TWIST1	Twist family bHLH transcription factor 1	0.5947	13
RIIAD1	Regulatory subunit of type II PKA R-subunit domain containing 1	0.5939	13
TTC8	Tetratricopeptide repeat domain 8	0.5931	13
PCDHB4	Protocadherin beta 4	0.5903	13
PKD1	Polycystin 1, transient receptor potential channel interacting	0.5885	20
RGS11	Regulator of G protein signaling 11	0.5872	13
NSMF	NMDA receptor synaptonuclear signaling and neuronal migration factor	0.5850	13
TCEAL5	Transcription elongation factor A like 5	0.5844	13
DOK4	Docking protein 4	0.5812	13
NPPA	Natriuretic peptide A	0.5763	13
CCDC74B	Coiled-coil domain containing 74B	0.5759	13
NSG2	Neuronal vesicle trafficking associated 2	0.5757	13

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.