Cell line - C7orf50 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	C7orf50
Gene descriptionⁱ Full gene name according to HGNC.	Chromosome 7 open reading frame 50
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	HEK293 & PC-3 - Transcription regulation (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

C7orf50 is part of cluster 19 HEK293 & PC-3 - Transcription regulation with confidenceⁱ 0.88
723 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
BRAT1	BRCA1 associated ATM activator 1	0.7314	19
PPP1R16A	Protein phosphatase 1 regulatory subunit 16A	0.6972	40
FBXL18	F-box and leucine rich repeat protein 18	0.6937	19
NUDT1	Nudix hydrolase 1	0.6891	19
INTS1	Integrator complex subunit 1	0.6466	19
CDCA4	Cell division cycle associated 4	0.6435	40
PSMG3	Proteasome assembly chaperone 3	0.6433	19
EXOSC4	Exosome component 4	0.6433	19
QRFP	Pyroglutamylated RFamide peptide	0.6350	19
CTXN1	Cortexin 1	0.6316	19
C7orf26	Chromosome 7 open reading frame 26	0.6300	19
PCDHA13	Protocadherin alpha 13	0.6225	19
CSNK2A3	Casein kinase 2 alpha 3	0.6178	19
NOL12	Nucleolar protein 12	0.6132	19
EFCAB9	EF-hand calcium binding domain 9	0.6087	17