Cell line - GPR180 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GPR180
Gene descriptionⁱ Full gene name according to HGNC.	G protein-coupled receptor 180
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Mesenchymal cell lines - Antiviral immune response (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

GPR180 is part of cluster 4 Mesenchymal cell lines - Antiviral immune response with confidenceⁱ 1
344 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GNB4	G protein subunit beta 4	0.6632	44
FBXL3	F-box and leucine rich repeat protein 3	0.6277	31
DDX60	DExD/H-box helicase 60	0.5735	4
ICMT	Isoprenylcysteine carboxyl methyltransferase	0.5686	34
TRIM21	Tripartite motif containing 21	0.5613	4
CEP55	Centrosomal protein 55	0.5611	26
DDX60L	DExD/H-box 60 like	0.5607	4
EIF2AK2	Eukaryotic translation initiation factor 2 alpha kinase 2	0.5581	4
MFSD14B	Major facilitator superfamily domain containing 14B	0.5443	42
CFAP57	Cilia and flagella associated protein 57	0.5411	42
COMMD3-BMI1	COMMD3-BMI1 readthrough	0.5377	44
TRIM68	Tripartite motif containing 68	0.5318	44
ABHD13	Abhydrolase domain containing 13	0.5296	43
MZT1	Mitotic spindle organizing protein 1	0.5267	32
ZDHHC6	Zinc finger DHHC-type palmitoyltransferase 6	0.5263	32