Cell line - ATXN7L2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ATXN7L2
Gene descriptionⁱ Full gene name according to HGNC.	Ataxin 7 like 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	JURKAT & MOLT-4 - Adaptive immune response (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

ATXN7L2 is part of cluster 22 JURKAT & MOLT-4 - Adaptive immune response with confidenceⁱ 1
459 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
C3orf70	Chromosome 3 open reading frame 70	0.6180	7
LY6H	Lymphocyte antigen 6 family member H	0.5897	22
ZNF746	Zinc finger protein 746	0.5787	19
TMEM271	Transmembrane protein 271	0.5751	7
DGKZ	Diacylglycerol kinase zeta	0.5642	7
KATNB1	Katanin regulatory subunit B1	0.5599	7
H3C1	H3 clustered histone 1	0.5571	40
TBC1D24	TBC1 domain family member 24	0.5409	7
TIMP1	TIMP metallopeptidase inhibitor 1	0.5332	34
OR10T2	Olfactory receptor family 10 subfamily T member 2	0.5235	22
GLT1D1	Glycosyltransferase 1 domain containing 1	0.5221	5
PELI2	Pellino E3 ubiquitin protein ligase family member 2	0.5215	22
H4C1	H4 clustered histone 1	0.5202	14
FAM240C	Family with sequence similarity 240 member C	0.5200	14
ALYREF	Aly/REF export factor	0.5194	24