Cell line - SHISA5 - The Human Protein Atlas

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SHISA5

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TISSUE

BRAIN

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METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SHISA5
Gene descriptionⁱ Full gene name according to HGNC.	Shisa family member 5
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	RT4 - Unknown function (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SHISA5 is part of cluster 15 RT4 - Unknown function with confidenceⁱ 0.99
240 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
EPAS1	Endothelial PAS domain protein 1	0.8130	15
IRAK2	Interleukin 1 receptor associated kinase 2	0.7500	4
ZNF600	Zinc finger protein 600	0.7221	15
AAK1	AP2 associated kinase 1	0.7045	15
ACOX1	Acyl-CoA oxidase 1	0.7045	15
ALAS1	5'-aminolevulinate synthase 1	0.6931	15
ACER2	Alkaline ceramidase 2	0.6895	15
ELF4	E74 like ETS transcription factor 4	0.6773	15
SLC9A1	Solute carrier family 9 member A1	0.6727	15
SNX2	Sorting nexin 2	0.6636	28
WFS1	Wolframin ER transmembrane glycoprotein	0.6530	28
GDF15	Growth differentiation factor 15	0.6441	28
PPARG	Peroxisome proliferator activated receptor gamma	0.6344	28
ACSF2	Acyl-CoA synthetase family member 2	0.6334	15
PLEKHG6	Pleckstrin homology and RhoGEF domain containing G6	0.6296	28

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.