Cell line - TMUB1 - The Human Protein Atlas

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TMUB1

SUMMARY

TISSUE

BRAIN

SINGLE CELL

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PATHOLOGY

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BLOOD

SUBCELL

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METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMUB1
Gene descriptionⁱ Full gene name according to HGNC.	Transmembrane and ubiquitin like domain containing 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

TMUB1 is part of cluster 40 Non-specific - Basic cellular processes with confidenceⁱ 0.98
557 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
C9orf16	Chromosome 9 open reading frame 16	0.7024	40
SLC25A42	Solute carrier family 25 member 42	0.6190	1
FKBP8	FKBP prolyl isomerase 8	0.6010	19
ABCB8	ATP binding cassette subfamily B member 8	0.5838	26
MED16	Mediator complex subunit 16	0.5729	19
EHBP1L1	EH domain binding protein 1 like 1	0.5723	19
ZBED6CL	ZBED6 C-terminal like	0.5694	44
ZNF282	Zinc finger protein 282	0.5652	19
ZNF746	Zinc finger protein 746	0.5636	19
TUBA3D	Tubulin alpha 3d	0.5583	19
KCTD13	Potassium channel tetramerization domain containing 13	0.5577	40
ZC3H3	Zinc finger CCCH-type containing 3	0.5516	40
BRD4	Bromodomain containing 4	0.5476	1
SPNS1	Sphingolipid transporter 1 (putative)	0.5447	24
ORAI1	ORAI calcium release-activated calcium modulator 1	0.5447	24

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.