Cell line - SHLD1 - The Human Protein Atlas

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SHLD1

SUMMARY

TISSUE

BRAIN

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PATHOLOGY

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METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SHLD1
Gene descriptionⁱ Full gene name according to HGNC.	Shieldin complex subunit 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	NB-4 - Immune response (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (NB-4, U-698)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SHLD1 is part of cluster 24 NB-4 - Immune response with confidenceⁱ 1
383 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
PTPRCAP	Protein tyrosine phosphatase receptor type C associated protein	0.8036	24
RPS6	Ribosomal protein S6	0.7810	24
HVCN1	Hydrogen voltage gated channel 1	0.7563	24
NCR3	Natural cytotoxicity triggering receptor 3	0.7551	24
NLRC3	NLR family CARD domain containing 3	0.7429	24
AC114402.2	Novel protein	0.7370	27
UGT2B28	UDP glucuronosyltransferase family 2 member B28	0.7358	24
ATM	ATM serine/threonine kinase	0.7081	27
RASGRP2	RAS guanyl releasing protein 2	0.6905	24
TRAJ17	T cell receptor alpha joining 17	0.6842	24
TEX12	Testis expressed 12	0.6723	27
IGHV3-72	Immunoglobulin heavy variable 3-72	0.6664	27
TGDS	TDP-glucose 4,6-dehydratase	0.6658	27
BIK	BCL2 interacting killer	0.6634	27
LTB	Lymphotoxin beta	0.6626	27

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.