Cell line - C11orf45 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	C11orf45
Gene descriptionⁱ Full gene name according to HGNC.	Chromosome 11 open reading frame 45
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Epithelial cell lines - Epithelial cell function (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HBEC3-KT, U-937)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

C11orf45 is part of cluster 42 Epithelial cell lines - Epithelial cell function with confidenceⁱ 1
593 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MET	MET proto-oncogene, receptor tyrosine kinase	0.7103	42
AGTRAP	Angiotensin II receptor associated protein	0.6654	42
SLCO1B3	Solute carrier organic anion transporter family member 1B3	0.6425	42
ELFN2	Extracellular leucine rich repeat and fibronectin type III domain containing 2	0.6387	42
DNTTIP1	Deoxynucleotidyltransferase terminal interacting protein 1	0.6334	42
KRT80	Keratin 80	0.6154	42
NCEH1	Neutral cholesterol ester hydrolase 1	0.6061	42
PHACTR3	Phosphatase and actin regulator 3	0.5949	43
GALE	UDP-galactose-4-epimerase	0.5893	42
NWD1	NACHT and WD repeat domain containing 1	0.5822	32
C5AR1	Complement C5a receptor 1	0.5820	32
RASSF7	Ras association domain family member 7	0.5634	42
SLCO1B3-SLCO1B7	SLCO1B3-SLCO1B7 readthrough	0.5621	20
LGALS9B	Galectin 9B	0.5611	42
GPR39	G protein-coupled receptor 39	0.5575	42