CEP57L1 protein expression summary - The Human Protein Atlas

HUMAN PROTEIN ATLAS SUMMARYⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Proteinⁱ Full gene name according to HGNC.	Centrosomal protein 57 like 1
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CEP57L1 (bA487F23.2, C6orf182, MGC21731)
Tissue specificityⁱ ??The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Low tissue specificity
Tissue expression clusterⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Testis - Cell cycle regulation (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Spermatocytes, Early spermatids)
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatocytes - Spermatogenesis (mainly)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed blood cell samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Brain specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category Read more	Low human brain regional specificity
Cancer prognostic summary	Gene product is not prognostic
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Subcellular summaryⁱ Describes the main and potential additional location(s) of the encoded protein according to ICC-IF resukt in the Cell Atlas, as well as potential data regarding cell cycle depency (CCD) for the RNA and/or protein expression.	Located in Plasma membrane, Cytosol
Protein function (UniProt)ⁱ Useful information about the protein provided by UniProt.	Centrosomal protein which may be required for microtubule attachment to centrosomes.... show less

TISSUEⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more

Tissue expression clusterⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Testis - Cell cycle regulation (mainly)
Tissue specificityⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Low tissue specificity
Tissue distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Protein expressionⁱ A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation. "Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile. Read more	General cytoplasmic and nuclear expression.

BRAINⁱ Summary of data presented in the Brain Atlas and a representative image of mRNA expression in the human brain. The image is clickable and will redirect to more Brain Atlas data. The Brain Atlas explores the protein expression in the mammalian brain by visualization and integration of data from three mammalian species (human, pig and mouse). Transcriptomics data combined with affinity-based protein in situ localization down to single cell level is available in a brain-centric sub atlas of the Human Protein Atlas. Read more

Human regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Pig regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Mouse regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity

SINGLE CELL TYPEⁱ Summary of data presented in the Single cell Type section, with an interactive chart showing the cell type-specific mRNA expression. The chart is clickable and will redirect to more Cell Type data. This section contains information about single cell type RNA expression based on scRNAseq of human tissues. The data also covers transcriptomics analysis of human blood and cultured cell lines. Read more

Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatocytes - Spermatogenesis (mainly)
Cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Spermatocytes, Early spermatids)

TISSUE CELL TYPEⁱ

Early spermatids

Classificationⁱ

Cell type enriched in single tissue

PATHOLOGYⁱ Summary of data presented in the Pathology section, with representative images of protein expression in cancer (left) and correlation between mRNA expression and patient survival (right). Images are clickable and redirect to pages with more Pathology data. This section contains mRNA and protein expression data from 17 different forms of human cancer, as well as correlation analysis of mRNA expression and patient survival. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more

Prognostic summary	Gene product is not prognostic
Cancer specificityⁱ Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. Read more	Low cancer specificity
Cancer distributionⁱ Distribution of RNA expression in 17 cancer types is categorized as either detected in single, detected in some, detected in many, detected in all, or not detected. Read more	Detected in all

IMMUNE CELLⁱ Summary of data presented in the Immune Cell section and a representative image of mRNA expression in immune cells in the blood. The image is clickable and will redirect to more immune cell related data. The Immune Cell section contains information regarding single cell type mRNA expression profiles of protein-coding genes in various immune cells in the blood, e.g. B-cells and granulocytes. Read more

Immune cell expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Basophils - Unknown function (mainly)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity

BLOOD PROTEINⁱ Summary of data presented in the Blood proteins section and a representative image of the concentration in plasma and related function for the protein in plasma. The image is clickable and will redirect to more data. The Blood proteins section contains plasma levels of proteins detected in human blood and an analysis of the human secretome (including annotation of the genes predicted to be actively secreted to human blood) is also presented. Read more
Detected in blood by immunoassayⁱ The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search. Read more	No (not applicable)
Detected in blood by mass spectrometryⁱ Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas.	No
Detected in blood by proximity extension assayⁱ Detection or not of the gene in blood, based on proximity extension assays (Olink) for a longitudinal wellness study covering 76 individuals with three visits during two years. Read more	No

SUBCELLULARⁱ Summary of data presented in the Cell Atlas and a representative image of subcellular localization. The Cell Atlas provides RNA expression data derived from RNA sequencing of a large panel of cell lines and protein localization data derived from antibody-based profiling by immunofluorescence confocal microscopy, using a subset of cell lines selected based on RNA expression. Read more

Main locationⁱ Main subcellular location(s) and reliability score(s) for the encoded protein(s) in human cells. The main location(s) may be characterized by presence in all tested cell lines and/or ihigher staining intensity compared to the potential additional location(s). If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively. Read more	Localized to the Plasma membrane, Cytosol

CELL LINEⁱ Summary of data presented in the Cell Line section and a representative image of mRNA expression across different human cell lines. The image is clickable and will redirect to more cell line data. This section contains information regarding mRNA expression profiles of human protein-coding genes for a large variety of cell lines. Read more

Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Cell cycle regulation (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell type distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all

METABOLIC

Metabolic info	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	CEP57L1 (HGNC Symbol)
Synonyms	bA487F23.2, C6orf182, MGC21731
Description	Centrosomal protein 57 like 1 (HGNC Symbol)
Chromosome	6
Cytoband	q21
Chromosome location (bp)	109095110 - 109174418
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	21
Protein evidence	Evidence at protein level (all genes)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more
Ensembl	ENSG00000183137 (version 103.38)
Entrez gene	285753
UniProt	Q8IYX8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IYX8
Antibodypedia	CEP57L1 antibodies

PROTEIN BROWSERⁱ

CEP57L1-201

CEP57L1-202

CEP57L1-203

CEP57L1-204

CEP57L1-205

CEP57L1-206

CEP57L1-207

CEP57L1-208

CEP57L1-209

CEP57L1-210

CEP57L1-213

CEP57L1-214

CEP57L1-215

CEP57L1-216

CEP57L1-218

CEP57L1-219

CEP57L1-220

CEP57L1-221

CEP57L1-222

CEP57L1-223

CEP57L1-224

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CEP57L1-201 ENSP00000352841 ENST00000359793	Q8IYX8 [Direct mapping] Centrosomal protein CEP57L1 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005856 [cytoskeleton] GO:0005874 [microtubule] GO:0008017 [microtubule binding] GO:0008150 [biological_process] GO:0042802 [identical protein binding] GO:0043015 [gamma-tubulin binding] Show all	460 aa 53.6 kDa	No	0
CEP57L1-202 ENSP00000357964 ENST00000368968	Q8IYX8 [Direct mapping] Centrosomal protein CEP57L1 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005856 [cytoskeleton] GO:0005874 [microtubule] GO:0008017 [microtubule binding] GO:0008150 [biological_process] GO:0042802 [identical protein binding] GO:0043015 [gamma-tubulin binding] Show all	391 aa 45.6 kDa	No	0
CEP57L1-203 ENSP00000357966 ENST00000368970	E5RFY4 [Direct mapping] Centrosomal protein CEP57L1 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0005737 [cytoplasm] GO:0008017 [microtubule binding] GO:0042802 [identical protein binding] GO:0043015 [gamma-tubulin binding] Show all	477 aa 55.4 kDa	No	0
CEP57L1-204 ENSP00000383936 ENST00000407272	Q6P2R3 [Direct mapping] C6orf182 protein; Centrosomal protein CEP57L1; Chromosome 6 open reading frame 182, isoform CRA_c Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0005515 [protein binding] GO:0042802 [identical protein binding] GO:0043015 [gamma-tubulin binding] Show all	251 aa 29.2 kDa	No	0
CEP57L1-205 ENSP00000427844 ENST00000517392	Q8IYX8 [Direct mapping] Centrosomal protein CEP57L1 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005737 [cytoplasm] GO:0005813 [centrosome] GO:0005815 [microtubule organizing center] GO:0005856 [cytoskeleton] GO:0005874 [microtubule] GO:0008017 [microtubule binding] GO:0008150 [biological_process] GO:0042802 [identical protein binding] GO:0043015 [gamma-tubulin binding] Show all	460 aa 53.6 kDa	No	0
CEP57L1-206 ENSP00000430402 ENST00000518329	E5RK85 [Direct mapping] Centrosomal protein CEP57L1 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all		53 aa 5.9 kDa	No	0
CEP57L1-207 ENSP00000430265 ENST00000518853	E5RG21 [Direct mapping] Centrosomal protein CEP57L1 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0042802 [identical protein binding] GO:0043015 [gamma-tubulin binding] Show all	230 aa 26.9 kDa	No	0
CEP57L1-208 ENSP00000430911 ENST00000519095	Q6P2R3 [Direct mapping] C6orf182 protein; Centrosomal protein CEP57L1; Chromosome 6 open reading frame 182, isoform CRA_c Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0005515 [protein binding] GO:0042802 [identical protein binding] GO:0043015 [gamma-tubulin binding] Show all	251 aa 29.2 kDa	No	0
CEP57L1-209 ENSP00000429812 ENST00000519286	E5RHF8 [Direct mapping] Centrosomal protein CEP57L1 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0042802 [identical protein binding] GO:0043015 [gamma-tubulin binding] Show all	206 aa 24.1 kDa	No	0
CEP57L1-210 ENSP00000430565 ENST00000519407	E5RJG4 [Direct mapping] Centrosomal protein CEP57L1 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0042802 [identical protein binding] GO:0043015 [gamma-tubulin binding] Show all	79 aa 9.6 kDa	No	0
CEP57L1-213 ENSP00000430011 ENST00000520883	Q5T6A0 [Direct mapping] Centrosomal protein CEP57L1 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0005737 [cytoplasm] GO:0008017 [microtubule binding] GO:0042802 [identical protein binding] GO:0043015 [gamma-tubulin binding] Show all	360 aa 42 kDa	No	0
CEP57L1-214 ENSP00000430558 ENST00000521277	E5RJH1 [Direct mapping] Centrosomal protein CEP57L1 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0042802 [identical protein binding] GO:0043015 [gamma-tubulin binding] Show all	235 aa 27.5 kDa	No	0
CEP57L1-215 ENSP00000431113 ENST00000521503	E5RJP9 [Direct mapping] Centrosomal protein CEP57L1 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0042802 [identical protein binding] GO:0043015 [gamma-tubulin binding] Show all	112 aa 12.8 kDa	No	0
CEP57L1-216 ENSP00000428344 ENST00000521522	E5RIV2 [Direct mapping] Centrosomal protein CEP57L1 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0005737 [cytoplasm] GO:0008017 [microtubule binding] GO:0042802 [identical protein binding] GO:0043015 [gamma-tubulin binding] Show all	407 aa 47.5 kDa	No	0
CEP57L1-218 ENSP00000429402 ENST00000522461	E5RIK8 [Direct mapping] Centrosomal protein CEP57L1 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all		28 aa 3.2 kDa	No	0
CEP57L1-219 ENSP00000429957 ENST00000522490	E5RGP2 [Direct mapping] Centrosomal protein CEP57L1 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0042802 [identical protein binding] GO:0043015 [gamma-tubulin binding] Show all	166 aa 19.7 kDa	No	0
CEP57L1-220 ENSP00000428464 ENST00000522608	E5RI49 [Direct mapping] Centrosomal protein CEP57L1 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0042802 [identical protein binding] GO:0043015 [gamma-tubulin binding] Show all	113 aa 13 kDa	No	0
CEP57L1-221 ENSP00000428682 ENST00000523174	H0YB52 [Direct mapping] Centrosomal protein CEP57L1 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0005737 [cytoplasm] GO:0008017 [microtubule binding] Show all	172 aa 19.9 kDa	No	0
CEP57L1-222 ENSP00000430013 ENST00000523209	E5RH23 [Direct mapping] Centrosomal protein CEP57L1 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0042802 [identical protein binding] GO:0043015 [gamma-tubulin binding] Show all	102 aa 12.1 kDa	No	0
CEP57L1-223 ENSP00000430529 ENST00000523787	G3V140 [Direct mapping] Centrosomal protein CEP57L1; Chromosome 6 open reading frame 182, isoform CRA_b Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0005737 [cytoplasm] GO:0008017 [microtubule binding] GO:0042802 [identical protein binding] GO:0043015 [gamma-tubulin binding] Show all	463 aa 54 kDa	No	0
CEP57L1-224 ENSP00000427771 ENST00000524064	E5RG82 [Direct mapping] Centrosomal protein CEP57L1 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0042802 [identical protein binding] GO:0043015 [gamma-tubulin binding] Show all	195 aa 22.7 kDa	No	0