Cell line - SPDYE4 - The Human Protein Atlas

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SPDYE4

SUMMARY

TISSUE

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METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SPDYE4
Gene descriptionⁱ Full gene name according to HGNC.	Speedy/RINGO cell cycle regulator family member E4
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	HeLa - Mitochondria (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (A549, HeLa, NB-4)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SPDYE4 is part of cluster 20 HeLa - Mitochondria with confidenceⁱ 1
435 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
NDUFS6	NADH:ubiquinone oxidoreductase subunit S6	0.8028	20
SPDYE5	Speedy/RINGO cell cycle regulator family member E5	0.7816	20
ANKRD61	Ankyrin repeat domain 61	0.7773	20
MT-ATP6	Mitochondrially encoded ATP synthase membrane subunit 6	0.7731	20
GLP2R	Glucagon like peptide 2 receptor	0.7634	20
SPINK13	Serine peptidase inhibitor Kazal type 13	0.7609	20
PDE4D	Phosphodiesterase 4D	0.7569	20
MARCOL	MARCO like	0.7486	20
IGFN1	Immunoglobulin like and fibronectin type III domain containing 1	0.7482	20
SLCO1C1	Solute carrier organic anion transporter family member 1C1	0.7482	20
LSMEM1	Leucine rich single-pass membrane protein 1	0.7439	20
KLHL1	Kelch like family member 1	0.7433	20
CRB1	Crumbs cell polarity complex component 1	0.7429	20
TBXT	T-box transcription factor T	0.7421	20
COL25A1	Collagen type XXV alpha 1 chain	0.7407	20

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.