Cell line - LAMP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LAMP1
Gene descriptionⁱ Full gene name according to HGNC.	Lysosomal associated membrane protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	CD markers Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Epithelial cell lines - Epithelial cell function (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

LAMP1 is part of cluster 42 Epithelial cell lines - Epithelial cell function with confidenceⁱ 1
593 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GSTK1	Glutathione S-transferase kappa 1	0.7389	42
TM9SF2	Transmembrane 9 superfamily member 2	0.6779	43
VSIR	V-set immunoregulatory receptor	0.6666	3
SKAP2	Src kinase associated phosphoprotein 2	0.6587	42
SLC52A3	Solute carrier family 52 member 3	0.6413	42
RNF141	Ring finger protein 141	0.6320	42
COLGALT1	Collagen beta(1-O)galactosyltransferase 1	0.6300	32
ANKRD22	Ankyrin repeat domain 22	0.6223	42
SYPL1	Synaptophysin like 1	0.6168	42
LGALS9B	Galectin 9B	0.6152	42
C1GALT1C1	C1GALT1 specific chaperone 1	0.6069	34
SDF4	Stromal cell derived factor 4	0.6026	34
ANO1	Anoctamin 1	0.6020	42
FUCA1	Alpha-L-fucosidase 1	0.5994	42
NCEH1	Neutral cholesterol ester hydrolase 1	0.5988	42