Cell line - NANOS1 - The Human Protein Atlas

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NANOS1

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NANOS1
Gene descriptionⁱ Full gene name according to HGNC.	Nanos C2HC-type zinc finger 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	SH-SY5Y - Nervous system development (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (SH-SY5Y, SK-BR-3, SK-MEL-30)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

NANOS1 is part of cluster 13 SH-SY5Y - Nervous system development with confidenceⁱ 1
375 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
TRIL	TLR4 interactor with leucine rich repeats	0.8393	13
LHFPL3	LHFPL tetraspan subfamily member 3	0.7994	13
CYB561	Cytochrome b561	0.7939	13
CACNG4	Calcium voltage-gated channel auxiliary subunit gamma 4	0.7791	13
COX4I2	Cytochrome c oxidase subunit 4I2	0.7583	13
HTR1E	5-hydroxytryptamine receptor 1E	0.7528	13
DOC2B	Double C2 domain beta	0.7500	13
CACNA2D2	Calcium voltage-gated channel auxiliary subunit alpha2delta 2	0.7492	13
ISL1	ISL LIM homeobox 1	0.7468	13
MARCHF11	Membrane associated ring-CH-type finger 11	0.7433	13
FAM163A	Family with sequence similarity 163 member A	0.7425	13
AC048338.2	Novel protein	0.7405	13
POPDC2	Popeye domain containing 2	0.7405	13
OPRM1	Opioid receptor mu 1	0.7405	13
SLC6A2	Solute carrier family 6 member 2	0.7401	13

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.