Cell line - NUGGC - The Human Protein Atlas

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NUGGC

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GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NUGGC
Gene descriptionⁱ Full gene name according to HGNC.	Nuclear GTPase, germinal center associated
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	U-698-M & Daudi - Adaptive immune response (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Group enriched (Daudi, Karpas-707, U-698)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

NUGGC is part of cluster 27 U-698-M & Daudi - Adaptive immune response with confidenceⁱ 1
505 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
OR13A1	Olfactory receptor family 13 subfamily A member 1	0.9591	27
GCSAM	Germinal center associated signaling and motility	0.9571	27
BACH2	BTB domain and CNC homolog 2	0.9559	27
IGKV1D-39	Immunoglobulin kappa variable 1D-39	0.9545	27
CD27	CD27 molecule	0.9536	27
AICDA	Activation induced cytidine deaminase	0.9520	27
MS4A1	Membrane spanning 4-domains A1	0.9510	27
FCRL2	Fc receptor like 2	0.9484	27
IGHV5-10-1	Immunoglobulin heavy variable 5-10-1	0.9415	27
IGLJ4	Immunoglobulin lambda joining 4 (non-functional)	0.9413	27
IGHM	Immunoglobulin heavy constant mu	0.9411	27
BFSP2	Beaded filament structural protein 2	0.9366	27
CD79A	CD79a molecule	0.9314	27
IGLJ6	Immunoglobulin lambda joining 6	0.9283	27
IGLJ5	Immunoglobulin lambda joining 5 (non-functional)	0.9231	27

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.