Cell line - VEPH1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	VEPH1
Gene descriptionⁱ Full gene name according to HGNC.	Ventricular zone expressed PH domain containing 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	10

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	TIME & HUVEC/TERT2 - Endothelial cell function (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (BJ hTERT+, hTERT-RPE1, HUVEC TERT2, TIME)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

VEPH1 is part of cluster 41 TIME & HUVEC/TERT2 - Endothelial cell function with confidenceⁱ 1
476 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ITGA5	Integrin subunit alpha 5	0.8808	41
JCAD	Junctional cadherin 5 associated	0.8433	41
COL13A1	Collagen type XIII alpha 1 chain	0.8267	41
GABBR2	Gamma-aminobutyric acid type B receptor subunit 2	0.8235	41
ADAMTSL1	ADAMTS like 1	0.8225	41
S1PR1	Sphingosine-1-phosphate receptor 1	0.8200	41
ESM1	Endothelial cell specific molecule 1	0.8170	41
MGARP	Mitochondria localized glutamic acid rich protein	0.8148	41
EFEMP1	EGF containing fibulin extracellular matrix protein 1	0.8142	41
SERPINE1	Serpin family E member 1	0.8109	41
THBS1	Thrombospondin 1	0.8095	41
LTBP2	Latent transforming growth factor beta binding protein 2	0.8057	41
MARCHF3	Membrane associated ring-CH-type finger 3	0.8030	41
SUSD5	Sushi domain containing 5	0.8018	41
PCDH10	Protocadherin 10	0.7941	41