Cell line - H2AC18 - The Human Protein Atlas

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H2AC18

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TISSUE

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METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	H2AC18
Gene descriptionⁱ Full gene name according to HGNC.	H2A clustered histone 18
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	U-266 - Adaptive immune response (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (Karpas-707, U-266/70, U-266/84)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

H2AC18 is part of cluster 29 U-266 - Adaptive immune response with confidenceⁱ 1
377 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
RBMY1J	RNA binding motif protein Y-linked family 1 member J	0.9480	29
SLC30A8	Solute carrier family 30 member 8	0.9443	29
IGKV3-20	Immunoglobulin kappa variable 3-20	0.9419	29
CTAG1A	Cancer/testis antigen 1A	0.9401	29
MAGEA9	MAGE family member A9	0.9362	29
FMR1NB	FMR1 neighbor	0.9344	29
TDRD15	Tudor domain containing 15	0.9328	29
IGHA2	Immunoglobulin heavy constant alpha 2 (A2m marker)	0.9302	29
H2BC7	H2B clustered histone 7	0.9245	29
IGLV2-8	Immunoglobulin lambda variable 2-8	0.9217	29
DCC	DCC netrin 1 receptor	0.9217	29
MYCL	MYCL proto-oncogene, bHLH transcription factor	0.9211	29
GPRC6A	G protein-coupled receptor class C group 6 member A	0.9176	29
TIMD4	T cell immunoglobulin and mucin domain containing 4	0.9150	29
IGLV2-33	Immunoglobulin lambda variable 2-33 (non-functional)	0.9095	29

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.