Cell line - IGLV7-43 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IGLV7-43
Gene descriptionⁱ Full gene name according to HGNC.	Immunoglobulin lambda variable 7-43
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Immunoglobulin genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	U-698-M & Daudi - Adaptive immune response (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (Daudi, RPMI-8226, U-698)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

IGLV7-43 is part of cluster 27 U-698-M & Daudi - Adaptive immune response with confidenceⁱ 1
505 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
IGLV1-44	Immunoglobulin lambda variable 1-44	0.8688	27
IGLV7-46	Immunoglobulin lambda variable 7-46	0.8654	27
BLK	BLK proto-oncogene, Src family tyrosine kinase	0.8573	27
TLR9	Toll like receptor 9	0.8281	27
TXLNB	Taxilin beta	0.8134	27
IGLV6-57	Immunoglobulin lambda variable 6-57	0.8081	27
CCDC195	Coiled-coil domain containing 195	0.7996	27
IGLV1-47	Immunoglobulin lambda variable 1-47	0.7636	27
IGKV1D-39	Immunoglobulin kappa variable 1D-39	0.7621	27
FRMPD3	FERM and PDZ domain containing 3	0.7605	27
IGLV11-55	Immunoglobulin lambda variable 11-55 (non-functional)	0.7534	27
IGKV2-40	Immunoglobulin kappa variable 2-40	0.7510	27
IGKV2D-40	Immunoglobulin kappa variable 2D-40	0.7468	27
IGKV5-2	Immunoglobulin kappa variable 5-2	0.7374	27
IGHM	Immunoglobulin heavy constant mu	0.7340	27