Cell line - IGHV3-66 - The Human Protein Atlas

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IGHV3-66

SUMMARY

TISSUE

BRAIN

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PATHOLOGY

IMMUNE

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CELL LINE

METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IGHV3-66
Gene descriptionⁱ Full gene name according to HGNC.	Immunoglobulin heavy variable 3-66
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Immunoglobulin genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	RPMI-8226 - Immune response (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (RPMI-8226, U-2 OS)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

IGHV3-66 is part of cluster 25 RPMI-8226 - Immune response with confidenceⁱ 1
313 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
GGTLC2	Gamma-glutamyltransferase light chain 2	0.7662	9
ADGRB1	Adhesion G protein-coupled receptor B1	0.7644	25
RGS22	Regulator of G protein signaling 22	0.7528	25
ATP2B2	ATPase plasma membrane Ca2+ transporting 2	0.7316	25
S100G	S100 calcium binding protein G	0.7200	25
PRSS2	Serine protease 2	0.7142	25
PNPLA5	Patatin like phospholipase domain containing 5	0.7138	25
CFC1	Cripto, FRL-1, cryptic family 1	0.7121	25
RSPH6A	Radial spoke head 6 homolog A	0.7055	25
CARNS1	Carnosine synthase 1	0.7022	25
ZP1	Zona pellucida glycoprotein 1	0.7010	25
RNF180	Ring finger protein 180	0.6998	25
CRYBB1	Crystallin beta B1	0.6992	25
BSND	Barttin CLCNK type accessory subunit beta	0.6970	25
CCDC187	Coiled-coil domain containing 187	0.6964	25

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.