Cell line - LEPROT - The Human Protein Atlas

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LEPROT

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BRAIN

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METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LEPROT
Gene descriptionⁱ Full gene name according to HGNC.	Leptin receptor overlapping transcript
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	RPTEC-TERT1 - Kidney processes (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (RPTEC TERT1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

LEPROT is part of cluster 35 RPTEC-TERT1 - Kidney processes with confidenceⁱ 1
329 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
SLC1A1	Solute carrier family 1 member 1	0.7595	35
PHYHD1	Phytanoyl-CoA dioxygenase domain containing 1	0.7322	35
RP1	RP1 axonemal microtubule associated	0.7028	35
TRPC6	Transient receptor potential cation channel subfamily C member 6	0.6955	35
NNMT	Nicotinamide N-methyltransferase	0.6903	35
SBSPON	Somatomedin B and thrombospondin type 1 domain containing	0.6856	35
ARL6IP5	ADP ribosylation factor like GTPase 6 interacting protein 5	0.6822	35
MTMR10	Myotubularin related protein 10	0.6806	35
ITM2B	Integral membrane protein 2B	0.6787	35
MT1M	Metallothionein 1M	0.6765	35
TLL2	Tolloid like 2	0.6698	35
TMEM30A	Transmembrane protein 30A	0.6660	35
SLC6A13	Solute carrier family 6 member 13	0.6636	35
DYNC2LI1	Dynein cytoplasmic 2 light intermediate chain 1	0.6628	35
PTH1R	Parathyroid hormone 1 receptor	0.6609	35

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.