Cell line - NEURL4 - The Human Protein Atlas

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NEURL4

SUMMARY

TISSUE

BRAIN

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PATHOLOGY

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CELL LINE

METABOLIC

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NEURL4
Gene descriptionⁱ Full gene name according to HGNC.	Neuralized E3 ubiquitin protein ligase 4
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across cell lines. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	HEK293 & PC-3 - Transcription regulation (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

CELL LINESⁱ

Organ

Expression

Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

NEURL4 is part of cluster 19 HEK293 & PC-3 - Transcription regulation with confidenceⁱ 1
723 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on cell line RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
KLHL17	Kelch like family member 17	0.6844	20
FGF22	Fibroblast growth factor 22	0.6747	23
C11orf42	Chromosome 11 open reading frame 42	0.6664	20
CDRT15	CMT1A duplicated region transcript 15	0.6660	19
PFAS	Phosphoribosylformylglycinamidine synthase	0.6460	26
CHRNA10	Cholinergic receptor nicotinic alpha 10 subunit	0.6433	19
TUBA3D	Tubulin alpha 3d	0.6433	19
FBXL19	F-box and leucine rich repeat protein 19	0.6350	19
DLX2	Distal-less homeobox 2	0.6318	23
ECEL1	Endothelin converting enzyme like 1	0.6300	23
SETD1A	SET domain containing 1A, histone lysine methyltransferase	0.6223	19
HOXA6	Homeobox A6	0.6178	19
PGLYRP1	Peptidoglycan recognition protein 1	0.6148	19
LENG8	Leukocyte receptor cluster member 8	0.6024	19
NUTM2G	NUT family member 2G	0.6022	39

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.