EGLN2 protein expression summary - The Human Protein Atlas

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EGLN2

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HUMAN PROTEIN ATLAS SUMMARYⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Proteinⁱ Full gene name according to HGNC.	Egl-9 family hypoxia inducible factor 2
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	EGLN2 (HIFPH1, PHD1)
Tissue specificityⁱ ??The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Low tissue specificity
Tissue expression clusterⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Testis - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids, Early spermatids)
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Spermatogenesis (mainly)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed blood cell samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Brain specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category Read more	Low human brain regional specificity
Cancer prognostic summary	Prognostic marker in cervical cancer (favorable) and pancreatic cancer (favorable)
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Subcellular summaryⁱ Describes the main and potential additional location(s) of the encoded protein according to ICC-IF resukt in the Cell Atlas, as well as potential data regarding cell cycle depency (CCD) for the RNA and/or protein expression.	Located in Nucleoplasm
Protein function (UniProt)ⁱ Useful information about the protein provided by UniProt.	Prolyl hydroxylase that mediates hydroxylation of proline residues in target proteins, such as ATF4, IKBKB, CEP192 and HIF1A 1, 2, 3, 4, 5, 6. Target proteins are preferentially recognized via a LXXLAP motif 7, 8, 9. Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins 10, 11, 12, 13, 14. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A 15, 16, 17, 18. Also hydroxylates HIF2A 19, 20, 21. Has a preference for the CODD site for both HIF1A and HIF2A 22, 23, 24. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex 25, 26, 27. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes 28, 29, 30. EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle 31, 32, 33. Also regulates susceptibility to normoxic oxidative neuronal death 34, 35, 36. Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation 37. Hydroxylates IKBKB, mediating NF-kappa-B activation in hypoxic conditions 38. Also mediates hydroxylation of ATF4, leading to decreased protein stability of ATF4 (By similarity).... show less
Molecular function (UniProt)ⁱ Keywords assigned by UniProt to proteins due to their particular molecular function.	Dioxygenase, Oxidoreductase
Ligand (UniProt)ⁱ Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.	Iron, Metal-binding, Vitamin C
Gene summary (Entrez)ⁱ Useful information about the gene from Entrez	The hypoxia inducible factor (HIF) is a transcriptional complex that is involved in oxygen homeostasis. At normal oxygen levels, the alpha subunit of HIF is targeted for degration by prolyl hydroxylation. This gene encodes an enzyme responsible for this post-translational modification. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream RAB4B (RAB4B, member RAS oncogene family) gene. [provided by RefSeq, Feb 2011]... show less

TISSUEⁱ Summary of data presented in the Tissue section, with a representative image of protein expression (left) and an interactive chart showing the tissue-specific mRNA expression (right). The image and the chart are clickable and will redirect to more Tissue data. This section contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more

Tissue expression clusterⁱ The RNA data was used to cluster genes according to their expression across tissues. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Testis - Spermatogenesis (mainly)
Tissue specificityⁱ The RNA specificity category is based on mRNA expression levels in the consensus dataset which is calculated from the RNA expression levels in samples from HPA and GTEX. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Low tissue specificity
Tissue distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA and GTEX. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all

BRAINⁱ Summary of data presented in the Brain Atlas and a representative image of mRNA expression in the human brain. The image is clickable and will redirect to more Brain Atlas data. The Brain Atlas explores the protein expression in the mammalian brain by visualization and integration of data from three mammalian species (human, pig and mouse). Transcriptomics data combined with affinity-based protein in situ localization down to single cell level is available in a brain-centric sub atlas of the Human Protein Atlas. Read more

Human regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Pig regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Mouse regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analysed brain samples, grouped into 13 main brain regions and calculated for the three different species. All brain expression profiles are based on data from HPA. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity

SINGLE CELL TYPEⁱ Summary of data presented in the Single cell Type section, with an interactive chart showing the cell type-specific mRNA expression. The chart is clickable and will redirect to more Cell Type data. This section contains information about single cell type RNA expression based on scRNAseq of human tissues. The data also covers transcriptomics analysis of human blood and cultured cell lines. Read more

Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Spermatogenesis (mainly)
Cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids, Early spermatids)

TISSUE CELL TYPEⁱ

Endothelial cells

Classificationⁱ

Core cell type enriched

PATHOLOGYⁱ Summary of data presented in the Pathology section, with representative images of protein expression in cancer (left) and correlation between mRNA expression and patient survival (right). Images are clickable and redirect to pages with more Pathology data. This section contains mRNA and protein expression data from 17 different forms of human cancer, as well as correlation analysis of mRNA expression and patient survival. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more
Cervical cancer p<0.001
Prognostic summary	Prognostic marker in cervical cancer (favorable) and pancreatic cancer (favorable)
Cancer specificityⁱ Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. Read more	Low cancer specificity
Cancer distributionⁱ Distribution of RNA expression in 17 cancer types is categorized as either detected in single, detected in some, detected in many, detected in all, or not detected. Read more	Detected in all

IMMUNE CELLⁱ Summary of data presented in the Immune Cell section and a representative image of mRNA expression in immune cells in the blood. The image is clickable and will redirect to more immune cell related data. The Immune Cell section contains information regarding single cell type mRNA expression profiles of protein-coding genes in various immune cells in the blood, e.g. B-cells and granulocytes. Read more

Immune cell expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Granulocytes - Unknown function (mainly)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity

BLOOD PROTEINⁱ Summary of data presented in the Blood proteins section and a representative image of the concentration in plasma and related function for the protein in plasma. The image is clickable and will redirect to more data. The Blood proteins section contains plasma levels of proteins detected in human blood and an analysis of the human secretome (including annotation of the genes predicted to be actively secreted to human blood) is also presented. Read more
Detected in blood by immunoassayⁱ The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search. Read more	No (not applicable)
Detected in blood by mass spectrometryⁱ Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas.	No
Detected in blood by proximity extension assayⁱ Detection or not of the gene in blood, based on proximity extension assays (Olink) for a longitudinal wellness study covering 76 individuals with three visits during two years. Read more	No

SUBCELLULARⁱ Summary of data presented in the Cell Atlas and a representative image of subcellular localization. The Cell Atlas provides RNA expression data derived from RNA sequencing of a large panel of cell lines and protein localization data derived from antibody-based profiling by immunofluorescence confocal microscopy, using a subset of cell lines selected based on RNA expression. Read more

Main locationⁱ Main subcellular location(s) and reliability score(s) for the encoded protein(s) in human cells. The main location(s) may be characterized by presence in all tested cell lines and/or ihigher staining intensity compared to the potential additional location(s). If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively. Read more	Localized to the Nucleoplasm

CELL LINEⁱ Summary of data presented in the Cell Line section and a representative image of mRNA expression across different human cell lines. The image is clickable and will redirect to more cell line data. This section contains information regarding mRNA expression profiles of human protein-coding genes for a large variety of cell lines. Read more

Cell line expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	THP-1 - Innate immune response (mainly)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell type distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many

METABOLIC

Metabolic info	Not available

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	EGLN2 (HGNC Symbol)
Synonyms	HIFPH1, PHD1
Description	Egl-9 family hypoxia inducible factor 2 (HGNC Symbol)
Chromosome	19
Cytoband	q13.2
Chromosome location (bp)	40798996 - 40808434
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	14
Protein evidence	Evidence at protein level (all genes)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Plasma proteins
Ensembl	ENSG00000269858 (version 103.38)
Entrez gene	112398
UniProt	Q96KS0 (UniProt - Evidence at protein level)
neXtProt	NX_Q96KS0
Antibodypedia	EGLN2 antibodies

PROTEIN BROWSERⁱ

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EGLN2-201

EGLN2-202

EGLN2-203

EGLN2-206

EGLN2-207

EGLN2-208

EGLN2-209

EGLN2-210

EGLN2-211

EGLN2-212

EGLN2-213

EGLN2-214

EGLN2-215

EGLN2-217

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PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EGLN2-201 ENSP00000307080 ENST00000303961	Q96KS0 [Direct mapping] Prolyl hydroxylase EGLN2 A0A024R0R2 [Target identity:100%; Query identity:100%] Egl nine homolog 2 (C. elegans), isoform CRA_b Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0001666 [response to hypoxia] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0008198 [ferrous iron binding] GO:0016491 [oxidoreductase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016706 [2-oxoglutarate-dependent dioxygenase activity] GO:0018401 [peptidyl-proline hydroxylation to 4-hydroxy-L-proline] GO:0019826 [oxygen sensor activity] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0031418 [L-ascorbic acid binding] GO:0031543 [peptidyl-proline dioxygenase activity] GO:0031545 [peptidyl-proline 4-dioxygenase activity] GO:0043523 [regulation of neuron apoptotic process] GO:0045454 [cell redox homeostasis] GO:0045732 [positive regulation of protein catabolic process] GO:0046872 [metal ion binding] GO:0051213 [dioxygenase activity] GO:0055114 [oxidation-reduction process] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071456 [cellular response to hypoxia] Show all	407 aa 43.7 kDa	No	0
EGLN2-202 ENSP00000385253 ENST00000406058	Q96KS0 [Direct mapping] Prolyl hydroxylase EGLN2 A0A024R0R2 [Target identity:100%; Query identity:100%] Egl nine homolog 2 (C. elegans), isoform CRA_b Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Show all	GO:0001558 [regulation of cell growth] GO:0001666 [response to hypoxia] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0008198 [ferrous iron binding] GO:0016491 [oxidoreductase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016706 [2-oxoglutarate-dependent dioxygenase activity] GO:0018401 [peptidyl-proline hydroxylation to 4-hydroxy-L-proline] GO:0019826 [oxygen sensor activity] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0031418 [L-ascorbic acid binding] GO:0031543 [peptidyl-proline dioxygenase activity] GO:0031545 [peptidyl-proline 4-dioxygenase activity] GO:0043523 [regulation of neuron apoptotic process] GO:0045454 [cell redox homeostasis] GO:0045732 [positive regulation of protein catabolic process] GO:0046872 [metal ion binding] GO:0051213 [dioxygenase activity] GO:0055114 [oxidation-reduction process] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071456 [cellular response to hypoxia] Show all	407 aa 43.7 kDa	No	0
EGLN2-203 ENSP00000472146 ENST00000593397	M0R1W4 [Direct mapping] Prolyl hydroxylase EGLN2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0005654 [nucleoplasm] Show all	72 aa 7.4 kDa	No	0
EGLN2-206 ENSP00000469272 ENST00000593525	M0QXM8 [Direct mapping] Prolyl hydroxylase EGLN2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0005654 [nucleoplasm] Show all	77 aa 7.9 kDa	No	0
EGLN2-207 ENSP00000469686 ENST00000593726	Q96KS0 [Direct mapping] Prolyl hydroxylase EGLN2 A0A024R0R2 [Target identity:100%; Query identity:100%] Egl nine homolog 2 (C. elegans), isoform CRA_b Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Show all	GO:0001558 [regulation of cell growth] GO:0001666 [response to hypoxia] GO:0005506 [iron ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0008198 [ferrous iron binding] GO:0016491 [oxidoreductase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0016706 [2-oxoglutarate-dependent dioxygenase activity] GO:0018401 [peptidyl-proline hydroxylation to 4-hydroxy-L-proline] GO:0019826 [oxygen sensor activity] GO:0030520 [intracellular estrogen receptor signaling pathway] GO:0031418 [L-ascorbic acid binding] GO:0031543 [peptidyl-proline dioxygenase activity] GO:0031545 [peptidyl-proline 4-dioxygenase activity] GO:0043523 [regulation of neuron apoptotic process] GO:0045454 [cell redox homeostasis] GO:0045732 [positive regulation of protein catabolic process] GO:0046872 [metal ion binding] GO:0051213 [dioxygenase activity] GO:0055114 [oxidation-reduction process] GO:0061418 [regulation of transcription from RNA polymerase II promoter in response to hypoxia] GO:0071456 [cellular response to hypoxia] Show all	407 aa 43.7 kDa	No	0
EGLN2-208 ENSP00000471546 ENST00000593972	M0R0Z6 [Direct mapping] Prolyl hydroxylase EGLN2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0005654 [nucleoplasm] Show all	139 aa 14.4 kDa	No	0
EGLN2-209 ENSP00000472414 ENST00000594140	A0A0C4DGR4 [Direct mapping] Prolyl hydroxylase EGLN2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0005506 [iron ion binding] GO:0016491 [oxidoreductase activity] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0031418 [L-ascorbic acid binding] GO:0046872 [metal ion binding] GO:0051213 [dioxygenase activity] GO:0055114 [oxidation-reduction process] Show all	125 aa 14.1 kDa	No	0
EGLN2-210 ENSP00000470968 ENST00000594380	M0R035 [Direct mapping] Prolyl hydroxylase EGLN2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0005654 [nucleoplasm] Show all	87 aa 8.8 kDa	No	0
EGLN2-211 ENSP00000471740 ENST00000595051	M0R1A3 [Direct mapping] Prolyl hydroxylase EGLN2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all		51 aa 5.7 kDa	No	0
EGLN2-212 ENSP00000471944 ENST00000595621	M0R1L0 [Direct mapping] Prolyl hydroxylase EGLN2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	96 aa 10.5 kDa	No	0
EGLN2-213 ENSP00000472870 ENST00000596517	M0R2X9 [Direct mapping] Prolyl hydroxylase EGLN2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all		67 aa 6.9 kDa	No	0
EGLN2-214 ENSP00000472991 ENST00000597746	M0R350 [Direct mapping] Prolyl hydroxylase EGLN2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0016491 [oxidoreductase activity] GO:0055114 [oxidation-reduction process] Show all	128 aa 14.2 kDa	No	0
EGLN2-215 ENSP00000471568 ENST00000598654	M0R110 [Direct mapping] Prolyl hydroxylase EGLN2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0005654 [nucleoplasm] Show all	101 aa 10.2 kDa	No	0
EGLN2-217 ENSP00000469323 ENST00000601733	M0QXR0 [Direct mapping] Prolyl hydroxylase EGLN2 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0005654 [nucleoplasm] Show all	94 aa 9.6 kDa	No	0

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