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Citing the Human Protein AtlasTo cite us, please use:
The Human Protein Atlas
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Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist PH, Berling H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Pontén F.
Tissue-based map of the human proteome.
Science 2015 347(6220):1260419.
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Brain
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Sjöstedt E, Zhong W, Fagerberg L, Karlsson M, Mitsios N, Adori C, Oksvold P, Edfors F, Limiszewska A, Hikmet F, Huang J, Du Y, Lin L, Dong Z, Yang L, Liu X, Jiang H, Xu X, Wang J, Yang H, Bolund L, Mardinoglu A, Zhang C, von Feilitzen K, Lindskog C, Pontén F, Luo Y, Hökfelt T, Uhlén M, Mulder J.
An atlas of the protein-coding genes in the human, pig, and mouse brain.
Science. 2020 367(6482)
PubMed: 32139519 DOI: 10.1126/science.aay5947
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Single Cell Type
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Karlsson M, Zhang C, Méar L, Zhong W, Digre A, Katona B, Sjöstedt E, Butler L, Odeberg J, Dusart P, Edfors F, Oksvold P, von Feilitzen K, Zwahlen M, Arif M, Altay O, Li X, Ozcan M, Mardinoglu A, Fagerberg L, Mulder J, Luo Y, Ponten F, Uhlén M, Lindskog C.
A single-cell type transcriptomics map of human tissues.
Sci Adv. 2021 7(31):.
PubMed: 34321199 DOI: 10.1126/sciadv.abh2169
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Pathology / Cancer
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Uhlen M, Zhang C, Lee S, Sjöstedt E, Fagerberg L, Bidkhori G, Benfeitas R, Arif M, Liu Z, Edfors F, Sanli K, von Feilitzen K, Oksvold P, Lundberg E, Hober S, Nilsson P, Mattsson J, Schwenk JM, Brunnström H, Glimelius B, Sjöblom T, Edqvist PH, Djureinovic D, Micke P, Lindskog C, Mardinoglu A, Ponten F.
A pathology atlas of the human cancer transcriptome.
Science. 2017 357(6352)
PubMed: 28818916 DOI: 10.1126/science.aan2507
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Immune Cells
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Uhlen M, Karlsson MJ, Zhong W, Tebani A, Pou C, Mikes J, Lakshmikanth T, Forsström B, Edfors F, Odeberg J, Mardinoglu A, Zhang C, von Feilitzen K, Mulder J, Sjöstedt E, Hober A, Oksvold P, Zwahlen M, Ponten F, Lindskog C, Sivertsson Å, Fagerberg L, Brodin P.
A genome-wide transcriptomic analysis of protein-coding genes in human blood cells.
Science. 2019 366(6472)
PubMed: 31857451 DOI: 10.1126/science.aax9198
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Human Secretome
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Uhlén M, Karlsson MJ, Hober A, Svensson AS, Scheffel J, Kotol D, Zhong W, Tebani A, Strandberg L, Edfors F, Sjöstedt E, Mulder J, Mardinoglu A, Berling A, Ekblad S, Dannemeyer M, Kanje S, Rockberg J, Lundqvist M, Malm M, Volk AL, Nilsson P, Månberg A, Dodig-Crnkovic T, Pin E, Zwahlen M, Oksvold P, von Feilitzen K, Häussler RS, Hong MG, Lindskog C, Ponten F, Katona B, Vuu J, Lindström E, Nielsen J, Robinson J, Ayoglu B, Mahdessian D, Sullivan D, Thul P, Danielsson F, Stadler C, Lundberg E, Bergström G, Gummesson A, Voldborg BG, Tegel H, Hober S, Forsström B, Schwenk JM, Fagerberg L, Sivertsson Å.
The human secretome.
Sci Signal. 2019 12(609)
PubMed: 31772123 DOI: 10.1126/scisignal.aaz0274 Free access: Abstract,
Full text,
Reprint
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Subcellular
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Thul PJ, Åkesson L, Wiking M, Mahdessian D, Geladaki A, Ait Blal H, Alm T, Asplund A, Björk L, Breckels LM, Bäckström A, Danielsson F, Fagerberg L, Fall J, Gatto L, Gnann C, Hober S, Hjelmare M, Johansson F, Lee S, Lindskog C, Mulder J, Mulvey CM, Nilsson P, Oksvold P, Rockberg J, Schutten R, Schwenk JM, Sivertsson Å, Sjöstedt E, Skogs M, Stadler C, Sullivan DP, Tegel H, Winsnes C, Zhang C, Zwahlen M, Mardinoglu A, Pontén F, von Feilitzen K, Lilley KS, Uhlén M, Lundberg E.
A subcellular map of the human proteome.
Science. 2017 356(6340): eaal3321
PubMed: 28495876 DOI: 10.1126/science.aal3321 Free access: Abstract,
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Reprint
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The original Human Protein Atlas publication
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Uhlén M, Björling E, Agaton C, Szigyarto CA, Amini B, Andersen E, Andersson AC, Angelidou P, Asplund A, Asplund C, Berglund L, Bergström K, Brumer H, Cerjan D, Ekström M, Elobeid A, Eriksson C, Fagerberg L, Falk R, Fall J, Forsberg M, Björklund MG, Gumbel K, Halimi A, Hallin I, Hamsten C, Hansson M, Hedhammar M, Hercules G, Kampf C, Larsson K, Lindskog M, Lodewyckx W, Lund J, Lundeberg J, Magnusson K, Malm E, Nilsson P, Odling J, Oksvold P, Olsson I, Oster E, Ottosson J, Paavilainen L, Persson A, Rimini R, Rockberg J, Runeson M, Sivertsson A, Sköllermo A, Steen J, Stenvall M, Sterky F, Strömberg S, Sundberg M, Tegel H, Tourle S, Wahlund E, Waldén A, Wan J, Wernérus H, Westberg J, Wester K, Wrethagen U, Xu LL, Hober S, Pontén F.
A human protein atlas for normal and cancer tissues based on antibody proteomics.
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Advances and Utility of the Human Plasma Proteome.
J Proteome Res. 2021 Epub ahead of print
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Nat Commun. 2021 12(1):3695.
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Combined metabolic activators therapy ameliorates liver fat in nonalcoholic fatty liver disease patients.
Mol Syst Biol. 2021 17(10):e10459.
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Zhong W, Altay O, Arif M, Edfors F, Doganay L, Mardinoglu A, Uhlén M, Fagerberg L.
Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms
EBioMedicine 2021 In Press
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Gerrits E, Brouwer N, Kooistra SM, Woodbury ME, Vermeiren Y, Lambourne M, Mulder J, Kummer M, Möller T, Biber K, Dunnen WFAD, De Deyn PP, Eggen BJL, Boddeke EWGM.
Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease.
Acta Neuropathol. 2021 141(5):681-696.
PubMed: 33609158 DOI: 10.1007/s00401-021-02263-w
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Mulder J, Lindqvist I, Rasmusson AJ, Husén E, Rönnelid J, Kumlien E, Rostami E, Virhammar J, Cunningham JL.
Indirect immunofluorescence for detecting anti-neuronal autoimmunity in CSF after COVID-19 - Possibilities and pitfalls.
Brain Behav Immun. 2021 94():473-474.
PubMed: 33631284 DOI: 10.1016/j.bbi.2021.02.013
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Huang J, Lin L, Dong Z, Yang L, Zheng T, Gu W, Zhang Y, Yin T, Sjöstedt E, Mulder J, Uhlén M, Kristiansen K, Bolund L, Luo Y.
A porcine brain-wide RNA editing landscape.
Commun Biol. 2021 4(1):717.
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Mulder J, Feresiadou A, Fällmar D, Frithiof R, Virhammar J, Rasmusson A, Rostami E, Kumlien E, Cunningham JL.
Autoimmune Encephalitis Presenting With Malignant Catatonia in a 40-Year-Old Male Patient With COVID-19.
Am J Psychiatry. 2021 178(6):485-489.
PubMed: 34154381 DOI: 10.1176/appi.ajp.2020.20081236
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Adori C, Daraio T, Kuiper R, Barde S, Horvathova L, Yoshitake T, Ihnatko R, Valladolid-Acebes I, Vercruysse P, Wellendorf AM, Gramignoli R, Bozoky B, Kehr J, Theodorsson E, Cancelas JA, Mravec B, Jorns C, Ellis E, Mulder J, Uhlén M, Bark C, Hökfelt T.
Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging.
Sci Adv. 2021 7(30):.
PubMed: 34290096 DOI: 10.1126/sciadv.abg5733
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Iglesias MJ, Kruse LD, Sanchez-Rivera L, Enge L, Dusart P, Hong MG, Uhlén M, Renné T, Schwenk JM, Bergstrom G, Odeberg J, Butler LM.
Identification of Endothelial Proteins in Plasma Associated With Cardiovascular Risk Factors.
Arterioscler Thromb Vasc Biol. 2021 ():ATVBAHA121316779.
PubMed: 34706560 DOI: 10.1161/ATVBAHA.121.316779
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Gnann C, Cesnik AJ, Lundberg E.
Illuminating Non-genetic Cellular Heterogeneity with Imaging-Based Spatial Proteomics.
Trends Cancer. 2021 7(4):278-282.
PubMed: 33436349 DOI: 10.1016/j.trecan.2020.12.006
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Rozenblatt-Rosen O, Shin JW, Rood JE, Hupalowska A, Human Cell Atlas Standards and Technology Working Group, Regev A, Heyn H.
Building a high-quality Human Cell Atlas.
Nat Biotechnol. 2021 39(2):149-153.
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Pycro-Manager: open-source software for customized and reproducible microscope control.
Nat Methods. 2021 18(3):226-228.
PubMed: 33674797 DOI: 10.1038/s41592-021-01087-6
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Gómez-de-Mariscal E, García-López-de-Haro C, Ouyang W, Donati L, Lundberg E, Unser M, Muñoz-Barrutia A, Sage D.
DeepImageJ: A user-friendly environment to run deep learning models in ImageJ.
Nat Methods. 2021 18(10):1192-1195.
PubMed: 34594030 DOI: 10.1038/s41592-021-01262-9
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Mikus M, Zandian A, Sjöberg R, Hamsten C, Forsström B, Andersson M, Greiff L, Uhlén M, Levin M, Nilsson P, van Hage M, Ohlin M.
Allergome-wide peptide microarrays enable epitope deconvolution in allergen-specific immunotherapy.
J Allergy Clin Immunol. 2021 147(3):1077-1086.
PubMed: 32791163 DOI: 10.1016/j.jaci.2020.08.002
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Hassan SS, Seigerud Å, Abdirahman R, Arroyo Mühr LS, Nordqvist Kleppe S, Pin E, Månberg A, Hober S, Nilsson P, Engstrand L, Miriam Elfström K, Blomqvist J, Conneryd Lundgren K, Dillner J.
SARS-CoV-2 infections amongst personnel providing home care services for older persons in Stockholm, Sweden.
J Intern Med. 2021 290(2):430-436.
PubMed: 33843090 DOI: 10.1111/joim.13274
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Månberg A, Skene N, Sanders F, Trusohamn M, Remnestål J, Szczepińska A, Aksoylu IS, Lönnerberg P, Ebarasi L, Wouters S, Lehmann M, Olofsson J, von Gohren Antequera I, Domaniku A, De Schaepdryver M, De Vocht J, Poesen K, Uhlén M, Anink J, Mijnsbergen C, Vergunst-Bosch H, Hübers A, Kläppe U, Rodriguez-Vieitez E, Gilthorpe JD, Hedlund E, Harris RA, Aronica E, Van Damme P, Ludolph A, Veldink J, Ingre C, Nilsson P, Lewandowski SA.
Altered perivascular fibroblast activity precedes ALS disease onset.
Nat Med. 2021 27(4):640-646.
PubMed: 33859435 DOI: 10.1038/s41591-021-01295-9
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| 708 |
Pin E, Petricoin EF, Cortes N, Bowman TG, Andersson E, Uhlén M, Nilsson P, Caswell SV.
Immunoglobulin A Autoreactivity toward Brain Enriched and Apoptosis-Regulating Proteins in Saliva of Athletes after Acute Concussion and Subconcussive Impacts.
J Neurotrauma. 2021 38(17):2373-2383.
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Lourido L, Balboa-Barreiro V, Ruiz-Romero C, Rego-Pérez I, Camacho-Encina M, Paz-González R, Calamia V, Oreiro N, Nilsson P, Blanco FJ.
A clinical model including protein biomarkers predicts radiographic knee osteoarthritis: a prospective study using data from the Osteoarthritis Initiative.
Osteoarthritis Cartilage. 2021 29(8):1147-1154.
PubMed: 33933586 DOI: 10.1016/j.joca.2021.04.011
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Alkharaan H, Bayati S, Hellström C, Aleman S, Olsson A, Lindahl K, Bogdanovic G, Healy K, Tsilingaridis G, De Palma P, Hober S, Månberg A, Nilsson P, Pin E, Sällberg Chen M.
Persisting Salivary IgG Against SARS-CoV-2 at 9 Months After Mild COVID-19: A Complementary Approach to Population Surveys.
J Infect Dis. 2021 224(3):407-414.
PubMed: 33978762 DOI: 10.1093/infdis/jiab256
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Kharlamova N, Dunn N, Bedri SK, Jerling S, Almgren M, Faustini F, Gunnarsson I, Rönnelid J, Pullerits R, Gjertsson I, Lundberg K, Månberg A, Pin E, Nilsson P, Hober S, Fink K, Fogdell-Hahn A.
False Positive Results in SARS-CoV-2 Serological Tests for Samples From Patients With Chronic Inflammatory Diseases.
Front Immunol. 2021 12():666114.
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Bergström S, Remnestål J, Yousef J, Olofsson J, Markaki I, Carvalho S, Corvol JC, Kultima K, Kilander L, Löwenmark M, Ingelsson M, Blennow K, Zetterberg H, Nellgård B, Brosseron F, Heneka MT, Bosch B, Sanchez-Valle R, Månberg A, Svenningsson P, Nilsson P.
Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease.
Ann Clin Transl Neurol. 2021 8(7):1456-1470.
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Hober S, Hellström C, Olofsson J, Andersson E, Bergström S, Jernbom Falk A, Bayati S, Mravinacova S, Sjöberg R, Yousef J, Skoglund L, Kanje S, Berling A, Svensson AS, Jensen G, Enstedt H, Afshari D, Xu LL, Zwahlen M, von Feilitzen K, Hanke L, Murrell B, McInerney G, Karlsson Hedestam GB, Lendel C, Roth RG, Skoog I, Svenungsson E, Olsson T, Fogdell-Hahn A, Lindroth Y, Lundgren M, Maleki KT, Lagerqvist N, Klingström J, Da Silva Rodrigues R, Muschiol S, Bogdanovic G, Arroyo Mühr LS, Eklund C, Lagheden C, Dillner J, Sivertsson Å, Havervall S, Thålin C, Tegel H, Pin E, Månberg A, Hedhammar M, Nilsson P.
Systematic evaluation of SARS-CoV-2 antigens enables a highly specific and sensitive multiplex serological COVID-19 assay.
Clin Transl Immunology. 2021 10(7):e1312.
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Differences in risk for SARS-CoV-2 infection among healthcare workers.
Prev Med Rep. 2021 24():101518.
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Havervall S, Ng H, Jernbom Falk A, Greilert-Norin N, Månberg A, Marking U, Laurén I, Gabrielsson L, Salomonsson AC, Aguilera K, Kihlgren M, Månsson M, Rosell A, Hellström C, Andersson E, Olofsson J, Skoglund L, Yousef J, Pin E, Lord M, Åberg M, Hedhammar M, Tegel H, Dönnes P, Phillipson M, Nilsson P, Klingström J, Mangsbo S, Hober S, Thålin C.
Robust humoral and cellular immune responses and low risk for reinfection at least 8 months following asymptomatic to mild COVID-19.
J Intern Med. 2021 Epub ahead of print
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Asplund Högelin K, Ruffin N, Pin E, Månberg A, Hober S, Gafvelin G, Grönlund H, Nilsson P, Khademi M, Olsson T, Piehl F, Al Nimer F.
Development of humoral and cellular immunological memory against SARS-CoV-2 despite B cell depleting treatment in multiple sclerosis.
iScience. 2021 24(9):103078.
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Mangsbo SM, Havervall S, Laurén I, Lindsay R, Jernbom Falk A, Marking U, Lord M, Buggert M, Dönnes P, Christoffersson G, Nilsson P, Hober S, Phillipson M, Klingström J, Thålin C.
An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responses.
PLoS One. 2021 16(9):e0258041.
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San Segundo-Acosta P, Montero-Calle A, Jernbom-Falk A, Alonso-Navarro M, Pin E, Andersson E, Hellström C, Sánchez-Martínez M, Rábano A, Solís-Fernández G, Peláez-García A, Martínez-Useros J, Fernández-Aceñero MJ, Månberg A, Nilsson P, Barderas R.
Multiomics Profiling of Alzheimer's Disease Serum for the Identification of Autoantibody Biomarkers.
J Proteome Res. 2021 20(11):5115-5130.
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Autoantibodies against the C-terminus of Lipopolysaccharide binding protein are elevated in young adults with psychiatric disease.
Psychoneuroendocrinology. 2021 126():105162.
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High Amounts of SARS-CoV-2 Precede Sickness Among Asymptomatic Health Care Workers.
J Infect Dis. 2021 224(1):14-20.
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Remnestål J, Bergström S, Olofsson J, Sjöstedt E, Uhlén M, Blennow K, Zetterberg H, Zettergren A, Kern S, Skoog I, Nilsson P, Månberg A.
Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds.
Alzheimers Res Ther. 2021 13(1):54.
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Cerebrospinal Fluid Proteins Altered in Corticobasal Degeneration.
Mov Disord. 2021 36(5):1278-1280.
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Dillner J, Elfström KM, Blomqvist J, Eklund C, Lagheden C, Nordqvist-Kleppe S, Hellström C, Olofsson J, Andersson E, Jernbom Falk A, Bergström S, Hultin E, Pin E, Månberg A, Nilsson P, Hedhammar M, Hober S, Mattsson J, Mühr LSA, Conneryd Lundgren K.
Antibodies to SARS-CoV-2 and risk of past or future sick leave.
Sci Rep. 2021 11(1):5160.
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Lourido L, Paz-González R, Ruiz-Romero C, Nilsson P, Blanco FJ.
Serum Proteomic Profiling in Rheumatoid Arthritis by Antibody Suspension Bead Arrays.
Methods Mol Biol. 2021 2259():143-151.
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Lindblad C, Pin E, Just D, Al Nimer F, Nilsson P, Bellander BM, Svensson M, Piehl F, Thelin EP.
Fluid proteomics of CSF and serum reveal important neuroinflammatory proteins in blood-brain barrier disruption and outcome prediction following severe traumatic brain injury: a prospective, observational study.
Crit Care. 2021 25(1):103.
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Röhl M, Tjernlund A, Lajoie J, Edfeldt G, Bradley F, Bergström S, Kaldhusdal V, Åhlberg A, Månberg A, Omollo K, Boily-Larouche G, Asghar M, Kwon DS, Oyugi J, Kimani J, Nilsson P, Fowke KR, Broliden K.
HIV-Exposed Seronegative Sex Workers Express Low T-Cell Activation and an Intact Ectocervical Tissue Microenvironment.
Vaccines (Basel). 2021 9(3):.
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Havervall S, Rosell A, Phillipson M, Mangsbo SM, Nilsson P, Hober S, Thålin C.
Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers.
JAMA. 2021 325(19):2015-2016.
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Mikus M, Järnbert-Pettersson H, Johansson C, Nilsson P, Scheynius A, Alm J.
Protein profiles in plasma: Development from infancy to 5 years of age.
Proteomics Clin Appl. 2021 15(4):e2000038.
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Risk of SARS-CoV-2 exposure among hospital healthcare workers in relation to patient contact and type of care.
Scand J Public Health. 2021 49(7):707-712.
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EBioMedicine. 2021 70():103523.
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Transl Psychiatry. 2021 11(1):474.
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Covid-19 in patients with chronic lymphocytic leukemia: clinical outcome and B- and T-cell immunity during 13 months in consecutive patients.
Leukemia. 2021 Epub ahead of print
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Mravinacova S, Jönsson M, Christ W, Klingström J, Yousef J, Hellström C, Hedhammar M, Havervall S, Thålin C, Pin E, Tegel H, Nilsson P, Månberg A, Hober S.
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N Biotechnol. 2021 66():46-52.
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Sci Transl Med. 2021 ():eabj7521.
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Mikus MS, Kolmert J, Andersson LI, Östling J, Knowles RG, Gómez C, Ericsson M, Thörngren JO, Khoonsari PE, Dahlén B, Kupczyk M, De Meulder B, Auffray C, Bakke PS, Beghe B, Bel EH, Caruso M, Chanez P, Chawes B, Fowler SJ, Gaga M, Geiser T, Gjomarkaj M, Horváth I, Howarth PH, Johnston SL, Joos G, Krug N, Montuschi P, Musial J, Niżankowska-Mogilnicka E, Olsson HK, Papi A, Rabe KF, Sandström T, Shaw DE, Siafakas NM, Uhlen M, Riley JH, Bates S, Middelveld RJM, Wheelock CE, Chung KF, Adcock IM, Sterk PJ, Djukanovic R, Nilsson P, Dahlén SE, James A, U–BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcome) Study Group, BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway Disease) Consortium.
Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation.
Eur Respir J. 2021 Epub ahead of print
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Altay O, Arif M, Li X, Yang H, Aydın M, Alkurt G, Kim W, Akyol D, Zhang C, Dinler-Doganay G, Turkez H, Shoaie S, Nielsen J, Borén J, Olmuscelik O, Doganay L, Uhlén M, Mardinoglu A.
Combined Metabolic Activators Accelerates Recovery in Mild-to-Moderate COVID-19.
Adv Sci (Weinh). 2021 8(17):e2101222.
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Arif M, Zhang C, Li X, Güngör C, Çakmak B, Arslantürk M, Tebani A, Özcan B, Subaş O, Zhou W, Piening B, Turkez H, Fagerberg L, Price N, Hood L, Snyder M, Nielsen J, Uhlen M, Mardinoglu A.
iNetModels 2.0: an interactive visualization and database of multi-omics data.
Nucleic Acids Res. 2021 49(W1):W271-W276.
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Arif M, Klevstig M, Benfeitas R, Doran S, Turkez H, Uhlén M, Clausen M, Wikström J, Etal D, Zhang C, Levin M, Mardinoglu A, Boren J.
Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction.
Elife. 2021 10():.
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Li SL, Pereira RHM, Prete CA, Zarebski AE, Emanuel L, Alves PJH, Peixoto PS, Braga CKV, de Souza Santos AA, de Souza WM, Barbosa RJ, Buss LF, Mendrone A, de Almeida-Neto C, Ferreira SC, Salles NA, Marcilio I, Wu CH, Gouveia N, Nascimento VH, Sabino EC, Faria NR, Messina JP.
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BMJ Glob Health. 2021 6(4):.
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A Resilient Health System in Response to Coronavirus Disease 2019: Experiences of Turkey.
Front Public Health. 2021 8():577021.
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Targeted Gene Candidates for Treatment and Early Diagnosis of Age-Related Macular Degeneration.
Biomed Res Int. 2021 2021():6620900.
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Systematic analysis of gut microbiome reveals the role of bacterial folate and homocysteine metabolism in Parkinson's disease.
Cell Rep. 2021 34(9):108807.
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Li X, Kim W, Juszczak K, Arif M, Sato Y, Kume H, Ogawa S, Turkez H, Boren J, Nielsen J, Uhlen M, Zhang C, Mardinoglu A.
Stratification of patients with clear cell renal cell carcinoma to facilitate drug repositioning.
iScience. 2021 24(7):102722.
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Spatiotemporal dissection of the cell cycle with single-cell proteogenomics.
Nature. 2021 590(7847):649-654.
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Alkurt G, Murt A, Aydin Z, Tatli O, Agaoglu NB, Irvem A, Aydin M, Karaali R, Gunes M, Yesilyurt B, Turkez H, Mardinoglu A, Doganay M, Basinoglu F, Seyahi N, Dinler Doganay G, Doganay HL.
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PLoS One. 2021 16(3):e0247865.
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Türkez H, Arslan ME, Sönmez E, Tatar A, Geyikoğlu F, Açikyildiz M, Mardinoğlu A.
Safety Assessments of Nickel Boride Nanoparticles on the Human Pulmonary Alveolar Cells by Using Cell Viability and Gene Expression Analyses.
Biol Trace Elem Res. 2021 199(7):2602-2611.
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Turkez H, Tozlu OO, Arslan ME, Mardinoglu A.
Safety and Efficacy Assessments to Take Antioxidants in Glioblastoma Therapy: From In Vitro Experiences to Animal and Clinical Studies.
Neurochem Int. 2021 150():105168.
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Revealing the Metabolic Alterations during Biofilm Development of Based on Genome-Scale Metabolic Modeling.
Metabolites. 2021 11(4):.
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Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies.
Neurochem Int. 2021 149():105137.
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Potential Anticancer Effect of Carvacrol Codrugs on Human Glioblastoma Cells.
Curr Drug Deliv. 2021 18(3):350-356.
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Doran S, Arif M, Lam S, Bayraktar A, Turkez H, Uhlen M, Boren J, Mardinoglu A.
Multi-omics approaches for revealing the complexity of cardiovascular disease.
Brief Bioinform. 2021 22(5):.
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van der Kolk BW, Saari S, Lovric A, Arif M, Alvarez M, Ko A, Miao Z, Sahebekhtiari N, Muniandy M, Heinonen S, Oghabian A, Jokinen R, Jukarainen S, Hakkarainen A, Lundbom J, Kuula J, Groop PH, Tukiainen T, Lundbom N, Rissanen A, Kaprio J, Williams EG, Zamboni N, Mardinoglu A, Pajukanta P, Pietiläinen KH.
Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI.
Cell Rep Med. 2021 2(4):100226.
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Zhao LJ, Li YY, Zhang YT, Fan QQ, Ren HM, Zhang C, Mardinoglu A, Chen WC, Pang JR, Shen DD, Wang JW, Zhao LF, Zhang JY, Wang ZY, Zheng YC, Liu HM.
Lysine demethylase LSD1 delivered via small extracellular vesicles promotes gastric cancer cell stemness.
EMBO Rep. 2021 22(8):e50922.
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Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target.
Gut. 2021 Epub ahead of print
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Informing Pharmacokinetic Models With Physiological Data: Oral Population Modeling of L-Serine in Humans.
Front Pharmacol. 2021 12():643179.
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Arslan ME, Türkez H, Mardinoğlu A.
In vitro neuroprotective effects of farnesene sesquiterpene on alzheimer's disease model of differentiated neuroblastoma cell line.
Int J Neurosci. 2021 131(8):745-754.
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Glycyl-L-Prolyl-L-Glutamate Pseudotripeptides for Treatment of Alzheimer's Disease.
Biomolecules. 2021 11(1):.
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Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking.
Eur Heart J. 2021 Epub ahead of print
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Editorial: Application of Systems Biology in Molecular Characterization and Diagnosis of Cancer.
Front Mol Biosci. 2021 8():668146.
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Li X, Kim W, Arif M, Gao C, Hober A, Kotol D, Strandberg L, Forsström B, Sivertsson Å, Oksvold P, Turkez H, Grøtli M, Sato Y, Kume H, Ogawa S, Boren J, Nielsen J, Uhlen M, Zhang C, Mardinoglu A.
Discovery of Functional Alternatively Spliced Transcripts in Human Cancers.
Cancers (Basel). 2021 13(2):.
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Anticancer effects of novel NSAIDs derivatives on cultured human glioblastoma cells.
Z Naturforsch C J Biosci. 2021 76(7-8):329-335.
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Addressing the heterogeneity in liver diseases using biological networks.
Brief Bioinform. 2021 22(2):1751-1766.
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Acute kidney injury leading to CKD is associated with a persistence of metabolic dysfunction and hypertriglyceridemia.
iScience. 2021 24(2):102046.
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A single-cell type transcriptomics map of human tissues.
Sci Adv. 2021 7(31):.
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Semin Cancer Biol. 2021 68():47-58.
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J Cachexia Sarcopenia Muscle. 2020 11(2):505-517.
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J Neuromuscul Dis. 2020 7(3):231-246.
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Transl Neurodegener. 2020 9(1):27.
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Association of serum anti-centromere protein F antibodies with clinical response to infliximab in patients with rheumatoid arthritis: A prospective study.
Semin Arthritis Rheum. 2020 50(5):1101-1108.
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Nat Commun. 2020 11(1):5064.
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Cerebrospinal Fluid Levels of Kininogen-1 Indicate Early Cognitive Impairment in Parkinson's Disease.
Mov Disord. 2020 35(11):2101-2106.
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Point-of-Care Approaches for Meningitis Diagnosis in a Low-Resource Setting (Southwestern Uganda): Observational Cohort Study Protocol of the "PI-POC" Trial.
JMIR Res Protoc. 2020 9(11):e21430.
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Transl Psychiatry. 2020 10(1):401.
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The in vitro cytotoxic, genotoxic, and oxidative damage potentials of the oral artificial sweetener aspartame on cultured human blood cells
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The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non-alcoholic fatty liver disease.
Mol Syst Biol. 2020 16(4):e9495.
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Front Neurosci. 2020 14():716.
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Skeletal Muscle Transcriptomic Comparison between Long-Term Trained and Untrained Men and Women.
Cell Rep. 2020 31(12):107808.
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Novel anti-Alzheimer phenol-lipoyl hybrids: Synthesis, physico-chemical characterization, and biological evaluation.
Eur J Med Chem. 2020 186():111880.
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Neuroprotective effects of boron nitride nanoparticles in the experimental Parkinson's disease model against MPP+ induced apoptosis.
Metab Brain Dis. 2020 35(6):947-957.
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MEMOTE for standardized genome-scale metabolic model testing.
Nat Biotechnol. 2020 38(3):272-276.
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iScience. 2020 23(11):101653.
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Adv Biosyst. 2020 4(6):e2000030.
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Histidyl-Proline Diketopiperazine Isomers as Multipotent Anti-Alzheimer Drug Candidates.
Biomolecules. 2020 10(5):.
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Front Genet. 2020 11():381.
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Mathivanan S, Ahmed M, Ahn NG, Alexandre H, Amanchy R, Andrews PC, Bader JS, Balgley BM, Bantscheff M, Bennett KL, Björling E, Blagoev B, Bose R, Brahmachari SK, Burlingame AS, Bustelo XR, Cagney G, Cantin GT, Cardasis HL, Celis JE, Chaerkady R, Chu F, Cole PA, Costello CE, Cotter RJ, Crockett D, DeLany JP, De Marzo AM, DeSouza LV, Deutsch EW, Dransfield E, Drewes G, Droit A, Dunn MJ, Elenitoba-Johnson K, Ewing RM, Van Eyk J, Faca V, Falkner J, Fang X, Fenselau C, Figeys D, Gagné P, Gelfi C, Gevaert K, Gimble JM, Gnad F, Goel R, Gromov P, Hanash SM, Hancock WS, Harsha HC, Hart G, Hays F, He F, Hebbar P, Helsens K, Hermeking H, Hide W, Hjernø K, Hochstrasser DF, Hofmann O, Horn DM, Hruban RH, Ibarrola N, James P, Jensen ON, Jensen PH, Jung P, Kandasamy K, Kheterpal I, Kikuno RF, Korf U, Körner R, Kuster B, Kwon MS, Lee HJ, Lee YJ, Lefevre M, Lehvaslaiho M, Lescuyer P, Levander F, Lim MS, Löbke C, Loo JA, Mann M, Martens L, Martinez-Heredia J, McComb M, McRedmond J, Mehrle A, Menon R, Miller CA, Mischak H, Mohan SS, Mohmood R, Molina H, Moran MF, Morgan JD, Moritz R, Morzel M, Muddiman DC, Nalli A, Navarro JD, Neubert TA, Ohara O, Oliva R, Omenn GS, Oyama M, Paik YK, Pennington K, Pepperkok R, Periaswamy B, Petricoin EF, Poirier GG, Prasad TS, Purvine SO, Rahiman BA, Ramachandran P, Ramachandra YL, Rice RH, Rick J, Ronnholm RH, Salonen J, Sanchez JC, Sayd T, Seshi B, Shankari K, Sheng SJ, Shetty V, Shivakumar K, Simpson RJ, Sirdeshmukh R, Siu KW, Smith JC, Smith RD, States DJ, Sugano S, Sullivan M, Superti-Furga G, Takatalo M, Thongboonkerd V, Trinidad JC, Uhlen M, Vandekerckhove J, Vasilescu J, Veenstra TD, Vidal-Taboada JM, Vihinen M, Wait R, Wang X, Wiemann S, Wu B, Xu T, Yates JR, Zhong J, Zhou M, Zhu Y, Zurbig P, Pandey A.
Human Proteinpedia enables sharing of human protein data.
Nat Biotechnol. 2008 26(2):164-7.
PubMed: 18259167 DOI: 10.1038/nbt0208-164
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Nestor M, Ekberg T, Dring J, van Dongen GA, Wester K, Tolmachev V, Anniko M.
Quantification of CD44v6 and EGFR expression in head and neck squamous cell carcinomas using a single-dose radioimmunoassay.
Tumour Biol. 2007 28(5):253-63.
PubMed: 17992053 DOI: 10.1159/000110898
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Sundqvist G, Stenvall M, Berglund H, Ottosson J, Brumer H.
A general, robust method for the quality control of intact proteins using LC-ESI-MS.
J Chromatogr B Analyt Technol Biomed Life Sci. 2007 852(1-2):188-94.
PubMed: 17267305 DOI: 10.1016/j.jchromb.2007.01.011
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Alm T, Steen J, Ottosson J, Hober S.
High-throughput protein purification under denaturating conditions by the use of cation exchange chromatography.
Biotechnol J. 2007 2(6):709-16.
PubMed: 17492715 DOI: 10.1002/biot.200700060
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Renberg B, Nordin J, Merca A, Uhlén M, Feldwisch J, Nygren PA, Karlström AE.
Affibody molecules in protein capture microarrays: evaluation of multidomain ligands and different detection formats.
J Proteome Res. 2007 6(1):171-9.
PubMed: 17203961 DOI: 10.1021/pr060316r
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Mulder J, Wernérus H, Shi TJ, Pontén F, Hober S, Uhlén M, Hökfelt T.
Systematically generated antibodies against human gene products: high throughput screening on sections from the rat nervous system.
Neuroscience. 2007 146(4):1689-703.
PubMed: 17478047 DOI: 10.1016/j.neuroscience.2007.02.054
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| 32 |
Orchard S, Heck A, Uhlen M, Ping P.
Publication Committee meeting. HUPO 5th annual World Congress. Long Beach, CA, USA 30 October 2006.
Proteomics. 2007 7(7):1009-11.
PubMed: 17340644 DOI: 10.1002/pmic.200700015
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| 31 |
Falk R, Ramström M, Ståhl S, Hober S.
Approaches for systematic proteome exploration.
Biomol Eng. 2007 24(2):155-68.
PubMed: 17376740 DOI: 10.1016/j.bioeng.2007.01.001
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| 30 |
Strömberg S, Björklund MG, Asplund C, Sköllermo A, Persson A, Wester K, Kampf C, Nilsson P, Andersson AC, Uhlen M, Kononen J, Ponten F, Asplund A.
A high-throughput strategy for protein profiling in cell microarrays using automated image analysis.
Proteomics. 2007 7(13):2142-50.
PubMed: 17549799 DOI: 10.1002/pmic.200700199
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| 29 |
Uhlen M.
Mapping the human proteome using antibodies
Mol Cell Proteomics 2007 6(8):1455-6.
PubMed: 17703056
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| 28 |
Bengtsson S, Krogh M, Szigyarto CA, Uhlen M, Schedvins K, Silfverswärd C, Linder S, Auer G, Alaiya A, James P.
Large-scale proteomics analysis of human ovarian cancer for biomarkers.
J Proteome Res. 2007 6(4):1440-50.
PubMed: 17315909 DOI: 10.1021/pr060593y
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| 27 |
Lofblom J, Kronqvist N, Uhlen M, Stahl S, Wernerus H.
Optimization of electroporation-mediated transformation: Staphylococcus carnosus as model organism.
J Appl Microbiol 2007 102(3):736-47.
PubMed: 17309623 DOI: 10.1111/j.1365-2672.2006.03127.x
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| 26 |
Lerner M, Corcoran M, Cepeda D, Nielsen ML, Zubarev R, Pontén F, Uhlén M, Hober S, Grandér D, Sangfelt O.
The RBCC gene RFP2 (Leu5) encodes a novel transmembrane E3 ubiquitin ligase involved in ERAD.
Mol Biol Cell. 2007 18(5):1670-82.
PubMed: 17314412 DOI: 10.1091/mbc.E06-03-0248
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| 25 |
Lundberg E, Sundberg M, Gräslund T, Uhlén M, Svahn HA.
A novel method for reproducible fluorescent labeling of small amounts of antibodies on solid phase.
J Immunol Methods. 2007 322(1-2):40-9.
PubMed: 17383674 DOI: 10.1016/j.jim.2007.01.023
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| 24 |
Patrakka J, Xiao Z, Nukui M, Takemoto M, He L, Oddsson A, Perisic L, Kaukinen A, Szigyarto CA, Uhlén M, Jalanko H, Betsholtz C, Tryggvason K.
Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik.
J Am Soc Nephrol. 2007 18(3):689-97.
PubMed: 17251388 DOI: 10.1681/ASN.2006060675
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| 23 |
Taussig MJ, Stoevesandt O, Borrebaeck CA, Bradbury AR, Cahill D, Cambillau C, de Daruvar A, Dubel S, Eichler J, Frank R, Gibson TJ, Gloriam D, Gold L, Herberg FW, Hermjakob H, Hoheisel JD, Joos TO, Kallioniemi O, Koegll M, Konthur Z, Korn B, Kremmer E, Krobitsch S, Landegren U, van der Maarel S, McCafferty J, Muyldermans S, Nygren PA, Palcy S, Pluckthun A, Polic B, Przybylski M, Saviranta P, Sawyer A, Sherman DJ, Skerra A, Templin M, Ueffing M, Uhlen M.
ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome.
Nature Methods 2007 4(1):13-7.
PubMed: 17195019 DOI: 10.1038/nmeth0107-13
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| 22 |
Schwenk JM, Lindberg J, Sundberg M, Uhlén M, Nilsson P.
Determination of binding specificities in highly multiplexed bead-based assays for antibody proteomics.
Mol Cell Proteomics. 2007 6(1):125-32.
PubMed: 17060675 DOI: 10.1074/mcp.T600035-MCP200
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| 21 |
Söderberg O, Gullberg M, Jarvius M, Ridderstråle K, Leuchowius KJ, Jarvius J, Wester K, Hydbring P, Bahram F, Larsson LG, Landegren U.
Direct observation of individual endogenous protein complexes in situ by proximity ligation.
Nat Methods. 2006 3(12):995-1000.
PubMed: 17072308 DOI: 10.1038/nmeth947
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| 20 |
Steen J, Uhlén M, Hober S, Ottosson J.
High-throughput protein purification using an automated set-up for high-yield affinity chromatography.
Protein Expr Purif. 2006 46(2):173-8.
PubMed: 16483795 DOI: 10.1016/j.pep.2005.12.010
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Andrade J, Berglund L, Uhlén M, Odeberg J.
Using Grid technology for computationally intensive applied bioinformatics analyses.
In Silico Biol. 2006 6(6):495-504.
PubMed: 17518760
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| 18 |
Persson A, Hober S, Uhlén M.
A human protein atlas based on antibody proteomics.
Curr Opin Mol Ther. 2006 8(3):185-90.
PubMed: 16774037
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| 17 |
Ek S, Andréasson U, Hober S, Kampf C, Pontén F, Uhlén M, Merz H, Borrebaeck CA.
From gene expression analysis to tissue microarrays: a rational approach to identify therapeutic and diagnostic targets in lymphoid malignancies.
Mol Cell Proteomics. 2006 5(6):1072-81.
PubMed: 16524965 DOI: 10.1074/mcp.M600077-MCP200
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| 16 |
Eriksson C, Agaton C, Kånge R, Sundberg M, Nilsson P, Ek B, Uhlén M, Gustafsson M, Hober S.
Microfluidic analysis of antibody specificity in a compact disk format.
J Proteome Res. 2006 5(7):1568-74.
PubMed: 16823963 DOI: 10.1021/pr050447c
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| 15 |
Haab BB, Paulovich AG, Anderson NL, Clark AM, Downing GJ, Hermjakob H, Labaer J, Uhlen M.
A reagent resource to identify proteins and peptides of interest for the cancer community: a workshop report.
Mol Cell Proteomics. 2006 5(10):1996-2007.
PubMed: 16867976 DOI: 10.1074/mcp.T600020-MCP200
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| 14 |
Larsson K, Wester K, Nilsson P, Uhlén M, Hober S, Wernérus H.
Multiplexed PrEST immunization for high-throughput affinity proteomics.
J Immunol Methods. 2006 315(1-2):110-20.
PubMed: 16949094 DOI: 10.1016/j.jim.2006.07.014
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| 13 |
Andersson AC, Strömberg S, Bäckvall H, Kampf C, Uhlen M, Wester K, Pontén F.
Analysis of protein expression in cell microarrays: a tool for antibody-based proteomics.
J Histochem Cytochem. 2006 54(12):1413-23.
PubMed: 16957166 DOI: 10.1369/jhc.6A7001.2006
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| 12 |
Rada-Iglesias A, Wallerman O, Koch C, Ameur A, Enroth S, Clelland G, Wester K, Wilcox S, Dovey OM, Ellis PD, Wraight VL, James K, Andrews R, Langford C, Dhami P, Carter N, Vetrie D, Pontén F, Komorowski J, Dunham I, Wadelius C.
Binding sites for metabolic disease related transcription factors inferred at base pair resolution by chromatin immunoprecipitation and genomic microarrays.
Hum Mol Genet. 2005 14(22):3435-47.
PubMed: 16221759 DOI: 10.1093/hmg/ddi378
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| 11 |
Janzi M, Odling J, Pan-Hammarström Q, Sundberg M, Lundeberg J, Uhlén M, Hammarström L, Nilsson P.
Serum microarrays for large scale screening of protein levels.
Mol Cell Proteomics. 2005 4(12):1942-7.
PubMed: 16131484 DOI: 10.1074/mcp.M500213-MCP200
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| 10 |
Nilsson P, Paavilainen L, Larsson K, Odling J, Sundberg M, Andersson AC, Kampf C, Persson A, Al-Khalili Szigyarto C, Ottosson J, Björling E, Hober S, Wernérus H, Wester K, Pontén F, Uhlen M.
Towards a human proteome atlas: high-throughput generation of mono-specific antibodies for tissue profiling.
Proteomics. 2005 5(17):4327-37.
PubMed: 16237735 DOI: 10.1002/pmic.200500072
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| 9 |
Hedhammar M, Stenvall M, Lönneborg R, Nord O, Sjölin O, Brismar H, Uhlén M, Ottosson J, Hober S.
A novel flow cytometry-based method for analysis of expression levels in Escherichia coli, giving information about precipitated and soluble protein.
J Biotechnol. 2005 119(2):133-46.
PubMed: 15996784 DOI: 10.1016/j.jbiotec.2005.03.024
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| 8 |
Stenvall M, Steen J, Uhlén M, Hober S, Ottosson J.
High-throughput solubility assay for purified recombinant protein immunogens.
Biochim Biophys Acta. 2005 1752(1):6-10.
PubMed: 16084133 DOI: 10.1016/j.bbapap.2005.07.002
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| 7 |
Uhlén M, Björling E, Agaton C, Szigyarto CA, Amini B, Andersen E, Andersson AC, Angelidou P, Asplund A, Asplund C, Berglund L, Bergström K, Brumer H, Cerjan D, Ekström M, Elobeid A, Eriksson C, Fagerberg L, Falk R, Fall J, Forsberg M, Björklund MG, Gumbel K, Halimi A, Hallin I, Hamsten C, Hansson M, Hedhammar M, Hercules G, Kampf C, Larsson K, Lindskog M, Lodewyckx W, Lund J, Lundeberg J, Magnusson K, Malm E, Nilsson P, Odling J, Oksvold P, Olsson I, Oster E, Ottosson J, Paavilainen L, Persson A, Rimini R, Rockberg J, Runeson M, Sivertsson A, Sköllermo A, Steen J, Stenvall M, Sterky F, Strömberg S, Sundberg M, Tegel H, Tourle S, Wahlund E, Waldén A, Wan J, Wernérus H, Westberg J, Wester K, Wrethagen U, Xu LL, Hober S, Pontén F.
A human protein atlas for normal and cancer tissues based on antibody proteomics.
Mol Cell Proteomics. 2005 4(12):1920-32.
PubMed: 16127175 DOI: 10.1074/mcp.M500279-MCP200
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| 6 |
Lindskog M, Rockberg J, Uhlen M, Sterky F.
Selection of protein epitopes for antibody production
Biotechniques 2005 38(5):723-7.
PubMed: 15945371
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| 5 |
Uhlen M, Ponten F.
Antibody-based proteomics for human tissue profiling.
Mol Cell Proteomics. 2005 4(4):384-93.
PubMed: 15695805 DOI: 10.1074/mcp.R500009-MCP200
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| 4 |
Kampf C, Andersson A-C, Wester K, Björling E, Uhlen M, Ponten F
Antibody-based tissue profiling as a tool in clinical proteomics
Clin. Proteomics 2004 1(3-4):285-300.
DOI: 10.1385/CP:1:3-4:285
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| 3 |
Agaton C, Uhlén M, Hober S.
Genome-based proteomics.
Electrophoresis. 2004 25(9):1280-8.
PubMed: 15174050 DOI: 10.1002/elps.200405846
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| 2 |
Agaton C, Falk R, Hoiden Guthenberg I, Gostring L, Uhlen M, Hober S.
Selective enrichment of monospecific polyclonal antibodies for antibody-based proteomics efforts.
J Chromatogr A 2004 16;1043(1):33-40.
PubMed: 15317410
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| 1 |
Agaton C, Galli J, Höidén Guthenberg I, Janzon L, Hansson M, Asplund A, Brundell E, Lindberg S, Ruthberg I, Wester K, Wurtz D, Höög C, Lundeberg J, Ståhl S, Pontén F, Uhlén M.
Affinity proteomics for systematic protein profiling of chromosome 21 gene products in human tissues.
Mol Cell Proteomics. 2003 2(6):405-14.
PubMed: 12796447 DOI: 10.1074/mcp.M300022-MCP200
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