Citing the Human Protein Atlas

To cite us, please use:

The Human Protein Atlas

Uhlén M, Fagerberg L, Hallström BM, Lindskog C, Oksvold P, Mardinoglu A, Sivertsson Å, Kampf C, Sjöstedt E, Asplund A, Olsson I, Edlund K, Lundberg E, Navani S, Szigyarto CA, Odeberg J, Djureinovic D, Takanen JO, Hober S, Alm T, Edqvist PH, Berling H, Tegel H, Mulder J, Rockberg J, Nilsson P, Schwenk JM, Hamsten M, von Feilitzen K, Forsberg M, Persson L, Johansson F, Zwahlen M, von Heijne G, Nielsen J, Pontén F.
Tissue-based map of the human proteome.
Science 2015 347(6220):1260419.
PubMed: 25613900 DOI: 10.1126/science.1260419

Brain

Sjöstedt E, Zhong W, Fagerberg L, Karlsson M, Mitsios N, Adori C, Oksvold P, Edfors F, Limiszewska A, Hikmet F, Huang J, Du Y, Lin L, Dong Z, Yang L, Liu X, Jiang H, Xu X, Wang J, Yang H, Bolund L, Mardinoglu A, Zhang C, von Feilitzen K, Lindskog C, Pontén F, Luo Y, Hökfelt T, Uhlén M, Mulder J.
An atlas of the protein-coding genes in the human, pig, and mouse brain.
Science. 2020 367(6482)
PubMed: 32139519 DOI: 10.1126/science.aay5947

Single Cell Type

Karlsson M, Zhang C, Méar L, Zhong W, Digre A, Katona B, Sjöstedt E, Butler L, Odeberg J, Dusart P, Edfors F, Oksvold P, von Feilitzen K, Zwahlen M, Arif M, Altay O, Li X, Ozcan M, Mardinoglu A, Fagerberg L, Mulder J, Luo Y, Ponten F, Uhlén M, Lindskog C.
A single-cell type transcriptomics map of human tissues.
Sci Adv. 2021 7(31):.
PubMed: 34321199 DOI: 10.1126/sciadv.abh2169

Pathology / Cancer

Uhlen M, Zhang C, Lee S, Sjöstedt E, Fagerberg L, Bidkhori G, Benfeitas R, Arif M, Liu Z, Edfors F, Sanli K, von Feilitzen K, Oksvold P, Lundberg E, Hober S, Nilsson P, Mattsson J, Schwenk JM, Brunnström H, Glimelius B, Sjöblom T, Edqvist PH, Djureinovic D, Micke P, Lindskog C, Mardinoglu A, Ponten F.
A pathology atlas of the human cancer transcriptome.
Science. 2017 357(6352)
PubMed: 28818916 DOI: 10.1126/science.aan2507

Immune Cells

Uhlen M, Karlsson MJ, Zhong W, Tebani A, Pou C, Mikes J, Lakshmikanth T, Forsström B, Edfors F, Odeberg J, Mardinoglu A, Zhang C, von Feilitzen K, Mulder J, Sjöstedt E, Hober A, Oksvold P, Zwahlen M, Ponten F, Lindskog C, Sivertsson Å, Fagerberg L, Brodin P.
A genome-wide transcriptomic analysis of protein-coding genes in human blood cells.
Science. 2019 366(6472)
PubMed: 31857451 DOI: 10.1126/science.aax9198

Human Secretome

Uhlén M, Karlsson MJ, Hober A, Svensson AS, Scheffel J, Kotol D, Zhong W, Tebani A, Strandberg L, Edfors F, Sjöstedt E, Mulder J, Mardinoglu A, Berling A, Ekblad S, Dannemeyer M, Kanje S, Rockberg J, Lundqvist M, Malm M, Volk AL, Nilsson P, Månberg A, Dodig-Crnkovic T, Pin E, Zwahlen M, Oksvold P, von Feilitzen K, Häussler RS, Hong MG, Lindskog C, Ponten F, Katona B, Vuu J, Lindström E, Nielsen J, Robinson J, Ayoglu B, Mahdessian D, Sullivan D, Thul P, Danielsson F, Stadler C, Lundberg E, Bergström G, Gummesson A, Voldborg BG, Tegel H, Hober S, Forsström B, Schwenk JM, Fagerberg L, Sivertsson Å.
The human secretome.
Sci Signal. 2019 12(609)
PubMed: 31772123 DOI: 10.1126/scisignal.aaz0274 Free access: Abstract, Full text, Reprint

Subcellular

Thul PJ, Åkesson L, Wiking M, Mahdessian D, Geladaki A, Ait Blal H, Alm T, Asplund A, Björk L, Breckels LM, Bäckström A, Danielsson F, Fagerberg L, Fall J, Gatto L, Gnann C, Hober S, Hjelmare M, Johansson F, Lee S, Lindskog C, Mulder J, Mulvey CM, Nilsson P, Oksvold P, Rockberg J, Schutten R, Schwenk JM, Sivertsson Å, Sjöstedt E, Skogs M, Stadler C, Sullivan DP, Tegel H, Winsnes C, Zhang C, Zwahlen M, Mardinoglu A, Pontén F, von Feilitzen K, Lilley KS, Uhlén M, Lundberg E.
A subcellular map of the human proteome.
Science. 2017 356(6340): eaal3321
PubMed: 28495876 DOI: 10.1126/science.aal3321 Free access: Abstract, Full text, Reprint

The original Human Protein Atlas publication

Uhlén M, Björling E, Agaton C, Szigyarto CA, Amini B, Andersen E, Andersson AC, Angelidou P, Asplund A, Asplund C, Berglund L, Bergström K, Brumer H, Cerjan D, Ekström M, Elobeid A, Eriksson C, Fagerberg L, Falk R, Fall J, Forsberg M, Björklund MG, Gumbel K, Halimi A, Hallin I, Hamsten C, Hansson M, Hedhammar M, Hercules G, Kampf C, Larsson K, Lindskog M, Lodewyckx W, Lund J, Lundeberg J, Magnusson K, Malm E, Nilsson P, Odling J, Oksvold P, Olsson I, Oster E, Ottosson J, Paavilainen L, Persson A, Rimini R, Rockberg J, Runeson M, Sivertsson A, Sköllermo A, Steen J, Stenvall M, Sterky F, Strömberg S, Sundberg M, Tegel H, Tourle S, Wahlund E, Waldén A, Wan J, Wernérus H, Westberg J, Wester K, Wrethagen U, Xu LL, Hober S, Pontén F.
A human protein atlas for normal and cancer tissues based on antibody proteomics.
Mol Cell Proteomics. 2005 4(12):1920-32.
PubMed: 16127175 DOI: 10.1074/mcp.M500279-MCP200

Publications

729 Deutsch EW, Omenn GS, Sun Z, Maes M, Pernemalm M, Palaniappan KK, Letunica N, Vandenbrouck Y, Brun V, Tao SC, Yu X, Geyer PE, Ignjatovic V, Moritz RL, Schwenk JM.
Advances and Utility of the Human Plasma Proteome.
J Proteome Res. 2021 Epub ahead of print
PubMed: 34672606 DOI: 10.1021/acs.jproteome.1c00657
728 Iglesias MJ, Schwenk JM, Odeberg J.
Affinity Proteomics Assays for Cardiovascular and Atherosclerotic Disease Biomarkers.
Methods Mol Biol. 2021 2344():163-179.
PubMed: 34115359 DOI: 10.1007/978-1-0716-1562-1_12
727 Bendes A, Dale M, Mattsson C, Dodig-Crnković T, Iglesias MJ, Schwenk JM, Fredolini C.
Bead-Based Assays for Validating Proteomic Profiles in Body Fluids.
Methods Mol Biol. 2021 2344():65-78.
PubMed: 34115352 DOI: 10.1007/978-1-0716-1562-1_5
726 Gummesson A, Björnson E, Fagerberg L, Zhong W, Tebani A, Edfors F, Schmidt C, Lundqvist A, Adiels M, Bäckhed F, Schwenk JM, Jansson PA, Uhlén M, Bergström G.
Longitudinal plasma protein profiling of newly diagnosed type 2 diabetes.
EBioMedicine. 2021 63():103147.
PubMed: 33279861 DOI: 10.1016/j.ebiom.2020.103147
725 Stockfelt M, Hong MG, Hesselmar B, Adlerberth I, Wold AE, Schwenk JM, Lundell AC, Rudin A.
Circulating proteins associated with allergy development in infants-an exploratory analysis.
Clin Proteomics. 2021 18(1):11.
PubMed: 33722194 DOI: 10.1186/s12014-021-09318-w
724 Roxhed N, Bendes A, Dale M, Mattsson C, Hanke L, Dodig-Crnković T, Christian M, Meineke B, Elsässer S, Andréll J, Havervall S, Thålin C, Eklund C, Dillner J, Beck O, Thomas CE, McInerney G, Hong MG, Murrell B, Fredolini C, Schwenk JM.
Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2.
Nat Commun. 2021 12(1):3695.
PubMed: 34140485 DOI: 10.1038/s41467-021-23893-4
723 Zeybel M, Altay O, Arif M, Li X, Yang H, Fredolini C, Akyildiz M, Saglam B, Gonenli MG, Ural D, Kim W, Schwenk JM, Zhang C, Shoaie S, Nielsen J, Uhlén M, Borén J, Mardinoglu A.
Combined metabolic activators therapy ameliorates liver fat in nonalcoholic fatty liver disease patients.
Mol Syst Biol. 2021 17(10):e10459.
PubMed: 34694070 DOI: 10.15252/msb.202110459
722 Zhong W, Altay O, Arif M, Edfors F, Doganay L, Mardinoglu A, Uhlén M, Fagerberg L.
Next generation plasma proteome profiling of COVID-19 patients with mild to moderate symptoms
EBioMedicine 2021 In Press

721 Gerrits E, Brouwer N, Kooistra SM, Woodbury ME, Vermeiren Y, Lambourne M, Mulder J, Kummer M, Möller T, Biber K, Dunnen WFAD, De Deyn PP, Eggen BJL, Boddeke EWGM.
Distinct amyloid-β and tau-associated microglia profiles in Alzheimer's disease.
Acta Neuropathol. 2021 141(5):681-696.
PubMed: 33609158 DOI: 10.1007/s00401-021-02263-w
720 Mulder J, Lindqvist I, Rasmusson AJ, Husén E, Rönnelid J, Kumlien E, Rostami E, Virhammar J, Cunningham JL.
Indirect immunofluorescence for detecting anti-neuronal autoimmunity in CSF after COVID-19 - Possibilities and pitfalls.
Brain Behav Immun. 2021 94():473-474.
PubMed: 33631284 DOI: 10.1016/j.bbi.2021.02.013
719 Huang J, Lin L, Dong Z, Yang L, Zheng T, Gu W, Zhang Y, Yin T, Sjöstedt E, Mulder J, Uhlén M, Kristiansen K, Bolund L, Luo Y.
A porcine brain-wide RNA editing landscape.
Commun Biol. 2021 4(1):717.
PubMed: 34112917 DOI: 10.1038/s42003-021-02238-3
718 Mulder J, Feresiadou A, Fällmar D, Frithiof R, Virhammar J, Rasmusson A, Rostami E, Kumlien E, Cunningham JL.
Autoimmune Encephalitis Presenting With Malignant Catatonia in a 40-Year-Old Male Patient With COVID-19.
Am J Psychiatry. 2021 178(6):485-489.
PubMed: 34154381 DOI: 10.1176/appi.ajp.2020.20081236
717 Adori C, Daraio T, Kuiper R, Barde S, Horvathova L, Yoshitake T, Ihnatko R, Valladolid-Acebes I, Vercruysse P, Wellendorf AM, Gramignoli R, Bozoky B, Kehr J, Theodorsson E, Cancelas JA, Mravec B, Jorns C, Ellis E, Mulder J, Uhlén M, Bark C, Hökfelt T.
Disorganization and degeneration of liver sympathetic innervations in nonalcoholic fatty liver disease revealed by 3D imaging.
Sci Adv. 2021 7(30):.
PubMed: 34290096 DOI: 10.1126/sciadv.abg5733
716 Iglesias MJ, Kruse LD, Sanchez-Rivera L, Enge L, Dusart P, Hong MG, Uhlén M, Renné T, Schwenk JM, Bergstrom G, Odeberg J, Butler LM.
Identification of Endothelial Proteins in Plasma Associated With Cardiovascular Risk Factors.
Arterioscler Thromb Vasc Biol. 2021 ():ATVBAHA121316779.
PubMed: 34706560 DOI: 10.1161/ATVBAHA.121.316779
715 Gnann C, Cesnik AJ, Lundberg E.
Illuminating Non-genetic Cellular Heterogeneity with Imaging-Based Spatial Proteomics.
Trends Cancer. 2021 7(4):278-282.
PubMed: 33436349 DOI: 10.1016/j.trecan.2020.12.006
714 Rozenblatt-Rosen O, Shin JW, Rood JE, Hupalowska A, Human Cell Atlas Standards and Technology Working Group, Regev A, Heyn H.
Building a high-quality Human Cell Atlas.
Nat Biotechnol. 2021 39(2):149-153.
PubMed: 33500565 DOI: 10.1038/s41587-020-00812-4
713 Pinkard H, Stuurman N, Ivanov IE, Anthony NM, Ouyang W, Li B, Yang B, Tsuchida MA, Chhun B, Zhang G, Mei R, Anderson M, Shepherd DP, Hunt-Isaak I, Dunn RL, Jahr W, Kato S, Royer LA, Thiagarajah JR, Eliceiri KW, Lundberg E, Mehta SB, Waller L.
Pycro-Manager: open-source software for customized and reproducible microscope control.
Nat Methods. 2021 18(3):226-228.
PubMed: 33674797 DOI: 10.1038/s41592-021-01087-6
712 Gómez-de-Mariscal E, García-López-de-Haro C, Ouyang W, Donati L, Lundberg E, Unser M, Muñoz-Barrutia A, Sage D.
DeepImageJ: A user-friendly environment to run deep learning models in ImageJ.
Nat Methods. 2021 18(10):1192-1195.
PubMed: 34594030 DOI: 10.1038/s41592-021-01262-9
711 Mikus M, Zandian A, Sjöberg R, Hamsten C, Forsström B, Andersson M, Greiff L, Uhlén M, Levin M, Nilsson P, van Hage M, Ohlin M.
Allergome-wide peptide microarrays enable epitope deconvolution in allergen-specific immunotherapy.
J Allergy Clin Immunol. 2021 147(3):1077-1086.
PubMed: 32791163 DOI: 10.1016/j.jaci.2020.08.002
710 Hassan SS, Seigerud Å, Abdirahman R, Arroyo Mühr LS, Nordqvist Kleppe S, Pin E, Månberg A, Hober S, Nilsson P, Engstrand L, Miriam Elfström K, Blomqvist J, Conneryd Lundgren K, Dillner J.
SARS-CoV-2 infections amongst personnel providing home care services for older persons in Stockholm, Sweden.
J Intern Med. 2021 290(2):430-436.
PubMed: 33843090 DOI: 10.1111/joim.13274
709 Månberg A, Skene N, Sanders F, Trusohamn M, Remnestål J, Szczepińska A, Aksoylu IS, Lönnerberg P, Ebarasi L, Wouters S, Lehmann M, Olofsson J, von Gohren Antequera I, Domaniku A, De Schaepdryver M, De Vocht J, Poesen K, Uhlén M, Anink J, Mijnsbergen C, Vergunst-Bosch H, Hübers A, Kläppe U, Rodriguez-Vieitez E, Gilthorpe JD, Hedlund E, Harris RA, Aronica E, Van Damme P, Ludolph A, Veldink J, Ingre C, Nilsson P, Lewandowski SA.
Altered perivascular fibroblast activity precedes ALS disease onset.
Nat Med. 2021 27(4):640-646.
PubMed: 33859435 DOI: 10.1038/s41591-021-01295-9
708 Pin E, Petricoin EF, Cortes N, Bowman TG, Andersson E, Uhlén M, Nilsson P, Caswell SV.
Immunoglobulin A Autoreactivity toward Brain Enriched and Apoptosis-Regulating Proteins in Saliva of Athletes after Acute Concussion and Subconcussive Impacts.
J Neurotrauma. 2021 38(17):2373-2383.
PubMed: 33858214 DOI: 10.1089/neu.2020.7375
707 Lourido L, Balboa-Barreiro V, Ruiz-Romero C, Rego-Pérez I, Camacho-Encina M, Paz-González R, Calamia V, Oreiro N, Nilsson P, Blanco FJ.
A clinical model including protein biomarkers predicts radiographic knee osteoarthritis: a prospective study using data from the Osteoarthritis Initiative.
Osteoarthritis Cartilage. 2021 29(8):1147-1154.
PubMed: 33933586 DOI: 10.1016/j.joca.2021.04.011
706 Alkharaan H, Bayati S, Hellström C, Aleman S, Olsson A, Lindahl K, Bogdanovic G, Healy K, Tsilingaridis G, De Palma P, Hober S, Månberg A, Nilsson P, Pin E, Sällberg Chen M.
Persisting Salivary IgG Against SARS-CoV-2 at 9 Months After Mild COVID-19: A Complementary Approach to Population Surveys.
J Infect Dis. 2021 224(3):407-414.
PubMed: 33978762 DOI: 10.1093/infdis/jiab256
705 Kharlamova N, Dunn N, Bedri SK, Jerling S, Almgren M, Faustini F, Gunnarsson I, Rönnelid J, Pullerits R, Gjertsson I, Lundberg K, Månberg A, Pin E, Nilsson P, Hober S, Fink K, Fogdell-Hahn A.
False Positive Results in SARS-CoV-2 Serological Tests for Samples From Patients With Chronic Inflammatory Diseases.
Front Immunol. 2021 12():666114.
PubMed: 34012450 DOI: 10.3389/fimmu.2021.666114
704 Bergström S, Remnestål J, Yousef J, Olofsson J, Markaki I, Carvalho S, Corvol JC, Kultima K, Kilander L, Löwenmark M, Ingelsson M, Blennow K, Zetterberg H, Nellgård B, Brosseron F, Heneka MT, Bosch B, Sanchez-Valle R, Månberg A, Svenningsson P, Nilsson P.
Multi-cohort profiling reveals elevated CSF levels of brain-enriched proteins in Alzheimer's disease.
Ann Clin Transl Neurol. 2021 8(7):1456-1470.
PubMed: 34129723 DOI: 10.1002/acn3.51402
703 Hober S, Hellström C, Olofsson J, Andersson E, Bergström S, Jernbom Falk A, Bayati S, Mravinacova S, Sjöberg R, Yousef J, Skoglund L, Kanje S, Berling A, Svensson AS, Jensen G, Enstedt H, Afshari D, Xu LL, Zwahlen M, von Feilitzen K, Hanke L, Murrell B, McInerney G, Karlsson Hedestam GB, Lendel C, Roth RG, Skoog I, Svenungsson E, Olsson T, Fogdell-Hahn A, Lindroth Y, Lundgren M, Maleki KT, Lagerqvist N, Klingström J, Da Silva Rodrigues R, Muschiol S, Bogdanovic G, Arroyo Mühr LS, Eklund C, Lagheden C, Dillner J, Sivertsson Å, Havervall S, Thålin C, Tegel H, Pin E, Månberg A, Hedhammar M, Nilsson P.
Systematic evaluation of SARS-CoV-2 antigens enables a highly specific and sensitive multiplex serological COVID-19 assay.
Clin Transl Immunology. 2021 10(7):e1312.
PubMed: 34295471 DOI: 10.1002/cti2.1312
702 Elfström KM, Blomqvist J, Nilsson P, Hober S, Pin E, Månberg A, Pimenoff VN, Arroyo Mühr LS, Lundgren KC, Dillner J.
Differences in risk for SARS-CoV-2 infection among healthcare workers.
Prev Med Rep. 2021 24():101518.
PubMed: 34458081 DOI: 10.1016/j.pmedr.2021.101518
701 Havervall S, Ng H, Jernbom Falk A, Greilert-Norin N, Månberg A, Marking U, Laurén I, Gabrielsson L, Salomonsson AC, Aguilera K, Kihlgren M, Månsson M, Rosell A, Hellström C, Andersson E, Olofsson J, Skoglund L, Yousef J, Pin E, Lord M, Åberg M, Hedhammar M, Tegel H, Dönnes P, Phillipson M, Nilsson P, Klingström J, Mangsbo S, Hober S, Thålin C.
Robust humoral and cellular immune responses and low risk for reinfection at least 8 months following asymptomatic to mild COVID-19.
J Intern Med. 2021 Epub ahead of print
PubMed: 34459525 DOI: 10.1111/joim.13387
700 Asplund Högelin K, Ruffin N, Pin E, Månberg A, Hober S, Gafvelin G, Grönlund H, Nilsson P, Khademi M, Olsson T, Piehl F, Al Nimer F.
Development of humoral and cellular immunological memory against SARS-CoV-2 despite B cell depleting treatment in multiple sclerosis.
iScience. 2021 24(9):103078.
PubMed: 34490414 DOI: 10.1016/j.isci.2021.103078
699 Mangsbo SM, Havervall S, Laurén I, Lindsay R, Jernbom Falk A, Marking U, Lord M, Buggert M, Dönnes P, Christoffersson G, Nilsson P, Hober S, Phillipson M, Klingström J, Thålin C.
An evaluation of a FluoroSpot assay as a diagnostic tool to determine SARS-CoV-2 specific T cell responses.
PLoS One. 2021 16(9):e0258041.
PubMed: 34591918 DOI: 10.1371/journal.pone.0258041
698 San Segundo-Acosta P, Montero-Calle A, Jernbom-Falk A, Alonso-Navarro M, Pin E, Andersson E, Hellström C, Sánchez-Martínez M, Rábano A, Solís-Fernández G, Peláez-García A, Martínez-Useros J, Fernández-Aceñero MJ, Månberg A, Nilsson P, Barderas R.
Multiomics Profiling of Alzheimer's Disease Serum for the Identification of Autoantibody Biomarkers.
J Proteome Res. 2021 20(11):5115-5130.
PubMed: 34628858 DOI: 10.1021/acs.jproteome.1c00630
697 Just D, Rasmusson AJ, Nilsson P, Noreland M, Malmström E, Brodin P, Månberg A, Cunningham JL.
Autoantibodies against the C-terminus of Lipopolysaccharide binding protein are elevated in young adults with psychiatric disease.
Psychoneuroendocrinology. 2021 126():105162.
PubMed: 33578084 DOI: 10.1016/j.psyneuen.2021.105162
696 Dillner J, Elfström KM, Blomqvist J, Engstrand L, Uhlén M, Eklund C, Boulund F, Lagheden C, Hamsten M, Nordqvist-Kleppe S, Seifert M, Hellström C, Olofsson J, Andersson E, Falk AJ, Bergström S, Hultin E, Pin E, Pimenoff VN, Hassan S, Månberg A, Nilsson P, Hedhammar M, Hober S, Mattsson J, Arroyo Mühr LS, Lundgren KC.
High Amounts of SARS-CoV-2 Precede Sickness Among Asymptomatic Health Care Workers.
J Infect Dis. 2021 224(1):14-20.
PubMed: 33580261 DOI: 10.1093/infdis/jiab099
695 Remnestål J, Bergström S, Olofsson J, Sjöstedt E, Uhlén M, Blennow K, Zetterberg H, Zettergren A, Kern S, Skoog I, Nilsson P, Månberg A.
Association of CSF proteins with tau and amyloid β levels in asymptomatic 70-year-olds.
Alzheimers Res Ther. 2021 13(1):54.
PubMed: 33653397 DOI: 10.1186/s13195-021-00789-5
694 Paslawski W, Bergström S, Zhang X, Remnestål J, He Y, Boxer A, Månberg A, Nilsson P, Svenningsson P.
Cerebrospinal Fluid Proteins Altered in Corticobasal Degeneration.
Mov Disord. 2021 36(5):1278-1280.
PubMed: 33660876 DOI: 10.1002/mds.28543
693 Dillner J, Elfström KM, Blomqvist J, Eklund C, Lagheden C, Nordqvist-Kleppe S, Hellström C, Olofsson J, Andersson E, Jernbom Falk A, Bergström S, Hultin E, Pin E, Månberg A, Nilsson P, Hedhammar M, Hober S, Mattsson J, Mühr LSA, Conneryd Lundgren K.
Antibodies to SARS-CoV-2 and risk of past or future sick leave.
Sci Rep. 2021 11(1):5160.
PubMed: 33664279 DOI: 10.1038/s41598-021-84356-w
692 Lourido L, Paz-González R, Ruiz-Romero C, Nilsson P, Blanco FJ.
Serum Proteomic Profiling in Rheumatoid Arthritis by Antibody Suspension Bead Arrays.
Methods Mol Biol. 2021 2259():143-151.
PubMed: 33687712 DOI: 10.1007/978-1-0716-1178-4_8
691 Lindblad C, Pin E, Just D, Al Nimer F, Nilsson P, Bellander BM, Svensson M, Piehl F, Thelin EP.
Fluid proteomics of CSF and serum reveal important neuroinflammatory proteins in blood-brain barrier disruption and outcome prediction following severe traumatic brain injury: a prospective, observational study.
Crit Care. 2021 25(1):103.
PubMed: 33712077 DOI: 10.1186/s13054-021-03503-x
690 Röhl M, Tjernlund A, Lajoie J, Edfeldt G, Bradley F, Bergström S, Kaldhusdal V, Åhlberg A, Månberg A, Omollo K, Boily-Larouche G, Asghar M, Kwon DS, Oyugi J, Kimani J, Nilsson P, Fowke KR, Broliden K.
HIV-Exposed Seronegative Sex Workers Express Low T-Cell Activation and an Intact Ectocervical Tissue Microenvironment.
Vaccines (Basel). 2021 9(3):.
PubMed: 33806390 DOI: 10.3390/vaccines9030217
689 Havervall S, Rosell A, Phillipson M, Mangsbo SM, Nilsson P, Hober S, Thålin C.
Symptoms and Functional Impairment Assessed 8 Months After Mild COVID-19 Among Health Care Workers.
JAMA. 2021 325(19):2015-2016.
PubMed: 33825846 DOI: 10.1001/jama.2021.5612
688 Mikus M, Järnbert-Pettersson H, Johansson C, Nilsson P, Scheynius A, Alm J.
Protein profiles in plasma: Development from infancy to 5 years of age.
Proteomics Clin Appl. 2021 15(4):e2000038.
PubMed: 33830667 DOI: 10.1002/prca.202000038
687 Klevebro S, Bahram F, Elfström KM, Hellberg U, Hober S, Merid SK, Kull I, Nilsson P, Tornvall P, Wang G, Conneryd Lundgren K, Ponzer S, Dillner J, Melén E.
Risk of SARS-CoV-2 exposure among hospital healthcare workers in relation to patient contact and type of care.
Scand J Public Health. 2021 49(7):707-712.
PubMed: 34148454 DOI: 10.1177/14034948211022434
686 Havervall S, Marking U, Greilert-Norin N, Ng H, Gordon M, Salomonsson AC, Hellström C, Pin E, Blom K, Mangsbo S, Phillipson M, Klingström J, Hober S, Nilsson P, Åberg M, Thålin C.
Antibody responses after a single dose of ChAdOx1 nCoV-19 vaccine in healthcare workers previously infected with SARS-CoV-2.
EBioMedicine. 2021 70():103523.
PubMed: 34391088 DOI: 10.1016/j.ebiom.2021.103523
685 Jernbom Falk A, Galletly C, Just D, Toben C, Baune BT, Clark SR, Liu D, Nilsson P, Månberg A, Schubert KO.
Autoantibody profiles associated with clinical features in psychotic disorders.
Transl Psychiatry. 2021 11(1):474.
PubMed: 34518517 DOI: 10.1038/s41398-021-01596-0
684 Blixt L, Bogdanovic G, Buggert M, Gao Y, Hober S, Healy K, Johansson H, Kjellander C, Mravinacova S, Muschiol S, Nilsson P, Palma M, Pin E, Smith CIE, Stromberg O, Sällberg Chen M, Zain R, Hansson L, Österborg A.
Covid-19 in patients with chronic lymphocytic leukemia: clinical outcome and B- and T-cell immunity during 13 months in consecutive patients.
Leukemia. 2021 Epub ahead of print
PubMed: 34564699 DOI: 10.1038/s41375-021-01424-w
683 Mravinacova S, Jönsson M, Christ W, Klingström J, Yousef J, Hellström C, Hedhammar M, Havervall S, Thålin C, Pin E, Tegel H, Nilsson P, Månberg A, Hober S.
A cell-free high throughput assay for assessment of SARS-CoV-2 neutralizing antibodies.
N Biotechnol. 2021 66():46-52.
PubMed: 34628049 DOI: 10.1016/j.nbt.2021.10.002
682 Carapito R, Li R, Helms J, Carapito C, Gujja S, Rolli V, Guimaraes R, Malagon-Lopez J, Spinnhirny P, Lederle A, Mohseninia R, Hirschler A, Muller L, Bastard P, Gervais A, Zhang Q, Danion F, Ruch Y, Schenck M, Collange O, Chamaraux-Tran TN, Molitor A, Pichot A, Bernard A, Tahar O, Bibi-Triki S, Wu H, Paul N, Mayeur S, Larnicol A, Laumond G, Frappier J, Schmidt S, Hanauer A, Macquin C, Stemmelen T, Simons M, Mariette X, Hermine O, Fafi-Kremer S, Goichot B, Drenou B, Kuteifan K, Pottecher J, Mertes PM, Kailasan S, Aman MJ, Pin E, Nilsson P, Thomas A, Viari A, Sanlaville D, Schneider F, Sibilia J, Tharaux PL, Casanova JL, Hansmann Y, Lidar D, Radosavljevic M, Gulcher JR, Meziani F, Moog C, Chittenden TW, Bahram S.
Identification of driver genes for critical forms of COVID-19 in a deeply phenotyped young patient cohort.
Sci Transl Med. 2021 ():eabj7521.
PubMed: 34698500 DOI: 10.1126/scitranslmed.abj7521
681 Mikus MS, Kolmert J, Andersson LI, Östling J, Knowles RG, Gómez C, Ericsson M, Thörngren JO, Khoonsari PE, Dahlén B, Kupczyk M, De Meulder B, Auffray C, Bakke PS, Beghe B, Bel EH, Caruso M, Chanez P, Chawes B, Fowler SJ, Gaga M, Geiser T, Gjomarkaj M, Horváth I, Howarth PH, Johnston SL, Joos G, Krug N, Montuschi P, Musial J, Niżankowska-Mogilnicka E, Olsson HK, Papi A, Rabe KF, Sandström T, Shaw DE, Siafakas NM, Uhlen M, Riley JH, Bates S, Middelveld RJM, Wheelock CE, Chung KF, Adcock IM, Sterk PJ, Djukanovic R, Nilsson P, Dahlén SE, James A, U–BIOPRED (Unbiased Biomarkers for the Prediction of Respiratory Disease outcome) Study Group, BIOAIR (Longitudinal Assessment of Clinical Course and Biomarkers in Severe Chronic Airway Disease) Consortium.
Plasma proteins elevated in severe asthma despite oral steroid use and unrelated to Type-2 inflammation.
Eur Respir J. 2021 Epub ahead of print
PubMed: 34737220 DOI: 10.1183/13993003.00142-2021
680 Altay O, Arif M, Li X, Yang H, Aydın M, Alkurt G, Kim W, Akyol D, Zhang C, Dinler-Doganay G, Turkez H, Shoaie S, Nielsen J, Borén J, Olmuscelik O, Doganay L, Uhlén M, Mardinoglu A.
Combined Metabolic Activators Accelerates Recovery in Mild-to-Moderate COVID-19.
Adv Sci (Weinh). 2021 8(17):e2101222.
PubMed: 34180141 DOI: 10.1002/advs.202101222
679 Arif M, Zhang C, Li X, Güngör C, Çakmak B, Arslantürk M, Tebani A, Özcan B, Subaş O, Zhou W, Piening B, Turkez H, Fagerberg L, Price N, Hood L, Snyder M, Nielsen J, Uhlen M, Mardinoglu A.
iNetModels 2.0: an interactive visualization and database of multi-omics data.
Nucleic Acids Res. 2021 49(W1):W271-W276.
PubMed: 33849075 DOI: 10.1093/nar/gkab254
678 Arif M, Klevstig M, Benfeitas R, Doran S, Turkez H, Uhlén M, Clausen M, Wikström J, Etal D, Zhang C, Levin M, Mardinoglu A, Boren J.
Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction.
Elife. 2021 10():.
PubMed: 33972017 DOI: 10.7554/eLife.66921
677 Li SL, Pereira RHM, Prete CA, Zarebski AE, Emanuel L, Alves PJH, Peixoto PS, Braga CKV, de Souza Santos AA, de Souza WM, Barbosa RJ, Buss LF, Mendrone A, de Almeida-Neto C, Ferreira SC, Salles NA, Marcilio I, Wu CH, Gouveia N, Nascimento VH, Sabino EC, Faria NR, Messina JP.
Higher risk of death from COVID-19 in low-income and non-White populations of São Paulo, Brazil.
BMJ Glob Health. 2021 6(4):.
PubMed: 33926892 DOI: 10.1136/bmjgh-2021-004959
676 Keskinkiliç B, Shaikh I, Tekin A, Ursu P, Mardinoglu A, Mese EA.
A Resilient Health System in Response to Coronavirus Disease 2019: Experiences of Turkey.
Front Public Health. 2021 8():577021.
PubMed: 33490014 DOI: 10.3389/fpubh.2020.577021
675 Cinici E, Caglar O, Arslan ME, Dilekmen N, Utlu B, Mardinoglu A, Turkez H.
Targeted Gene Candidates for Treatment and Early Diagnosis of Age-Related Macular Degeneration.
Biomed Res Int. 2021 2021():6620900.
PubMed: 33604378 DOI: 10.1155/2021/6620900
674 Rosario D, Bidkhori G, Lee S, Bedarf J, Hildebrand F, Le Chatelier E, Uhlen M, Ehrlich SD, Proctor G, Wüllner U, Mardinoglu A, Shoaie S.
Systematic analysis of gut microbiome reveals the role of bacterial folate and homocysteine metabolism in Parkinson's disease.
Cell Rep. 2021 34(9):108807.
PubMed: 33657381 DOI: 10.1016/j.celrep.2021.108807
673 Li X, Kim W, Juszczak K, Arif M, Sato Y, Kume H, Ogawa S, Turkez H, Boren J, Nielsen J, Uhlen M, Zhang C, Mardinoglu A.
Stratification of patients with clear cell renal cell carcinoma to facilitate drug repositioning.
iScience. 2021 24(7):102722.
PubMed: 34258555 DOI: 10.1016/j.isci.2021.102722
672 Mahdessian D, Cesnik AJ, Gnann C, Danielsson F, Stenström L, Arif M, Zhang C, Le T, Johansson F, Shutten R, Bäckström A, Axelsson U, Thul P, Cho NH, Carja O, Uhlén M, Mardinoglu A, Stadler C, Lindskog C, Ayoglu B, Leonetti MD, Pontén F, Sullivan DP, Lundberg E.
Spatiotemporal dissection of the cell cycle with single-cell proteogenomics.
Nature. 2021 590(7847):649-654.
PubMed: 33627808 DOI: 10.1038/s41586-021-03232-9
671 Alkurt G, Murt A, Aydin Z, Tatli O, Agaoglu NB, Irvem A, Aydin M, Karaali R, Gunes M, Yesilyurt B, Turkez H, Mardinoglu A, Doganay M, Basinoglu F, Seyahi N, Dinler Doganay G, Doganay HL.
Seroprevalence of coronavirus disease 2019 (COVID-19) among health care workers from three pandemic hospitals of Turkey.
PLoS One. 2021 16(3):e0247865.
PubMed: 33657142 DOI: 10.1371/journal.pone.0247865
670 Türkez H, Arslan ME, Sönmez E, Tatar A, Geyikoğlu F, Açikyildiz M, Mardinoğlu A.
Safety Assessments of Nickel Boride Nanoparticles on the Human Pulmonary Alveolar Cells by Using Cell Viability and Gene Expression Analyses.
Biol Trace Elem Res. 2021 199(7):2602-2611.
PubMed: 32909113 DOI: 10.1007/s12011-020-02374-7
669 Turkez H, Tozlu OO, Arslan ME, Mardinoglu A.
Safety and Efficacy Assessments to Take Antioxidants in Glioblastoma Therapy: From In Vitro Experiences to Animal and Clinical Studies.
Neurochem Int. 2021 150():105168.
PubMed: 34450218 DOI: 10.1016/j.neuint.2021.105168
668 Altay O, Zhang C, Turkez H, Nielsen J, Uhlén M, Mardinoglu A.
Revealing the Metabolic Alterations during Biofilm Development of Based on Genome-Scale Metabolic Modeling.
Metabolites. 2021 11(4):.
PubMed: 33916474 DOI: 10.3390/metabo11040221
667 Turkez H, Arslan ME, Tatar A, Mardinoglu A.
Promising potential of boron compounds against Glioblastoma: In Vitro antioxidant, anti-inflammatory and anticancer studies.
Neurochem Int. 2021 149():105137.
PubMed: 34293392 DOI: 10.1016/j.neuint.2021.105137
666 Yazici A, Marinelli L, Cacciatore I, Emsen B, Eusepi P, Di Biase G, Di Stefano A, Mardinoğlu A, Türkez H.
Potential Anticancer Effect of Carvacrol Codrugs on Human Glioblastoma Cells.
Curr Drug Deliv. 2021 18(3):350-356.
PubMed: 33109049 DOI: 10.2174/1567201817666201027123424
665 Doran S, Arif M, Lam S, Bayraktar A, Turkez H, Uhlen M, Boren J, Mardinoglu A.
Multi-omics approaches for revealing the complexity of cardiovascular disease.
Brief Bioinform. 2021 22(5):.
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664 van der Kolk BW, Saari S, Lovric A, Arif M, Alvarez M, Ko A, Miao Z, Sahebekhtiari N, Muniandy M, Heinonen S, Oghabian A, Jokinen R, Jukarainen S, Hakkarainen A, Lundbom J, Kuula J, Groop PH, Tukiainen T, Lundbom N, Rissanen A, Kaprio J, Williams EG, Zamboni N, Mardinoglu A, Pajukanta P, Pietiläinen KH.
Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI.
Cell Rep Med. 2021 2(4):100226.
PubMed: 33948567 DOI: 10.1016/j.xcrm.2021.100226
663 Zhao LJ, Li YY, Zhang YT, Fan QQ, Ren HM, Zhang C, Mardinoglu A, Chen WC, Pang JR, Shen DD, Wang JW, Zhao LF, Zhang JY, Wang ZY, Zheng YC, Liu HM.
Lysine demethylase LSD1 delivered via small extracellular vesicles promotes gastric cancer cell stemness.
EMBO Rep. 2021 22(8):e50922.
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662 Smati S, Polizzi A, Fougerat A, Ellero-Simatos S, Blum Y, Lippi Y, Régnier M, Laroyenne A, Huillet M, Arif M, Zhang C, Lasserre F, Marrot A, Al Saati T, Wan J, Sommer C, Naylies C, Batut A, Lukowicz C, Fougeray T, Tramunt B, Dubot P, Smith L, Bertrand-Michel J, Hennuyer N, Pradere JP, Staels B, Burcelin R, Lenfant F, Arnal JF, Levade T, Gamet-Payrastre L, Lagarrigue S, Loiseau N, Lotersztajn S, Postic C, Wahli W, Bureau C, Guillaume M, Mardinoglu A, Montagner A, Gourdy P, Guillou H.
Integrative study of diet-induced mouse models of NAFLD identifies PPARα as a sexually dimorphic drug target.
Gut. 2021 Epub ahead of print
PubMed: 33903148 DOI: 10.1136/gutjnl-2020-323323
661 Bosley JR, Björnson E, Zhang C, Turkez H, Nielsen J, Uhlen M, Borén J, Mardinoglu A.
Informing Pharmacokinetic Models With Physiological Data: Oral Population Modeling of L-Serine in Humans.
Front Pharmacol. 2021 12():643179.
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660 Arslan ME, Türkez H, Mardinoğlu A.
In vitro neuroprotective effects of farnesene sesquiterpene on alzheimer's disease model of differentiated neuroblastoma cell line.
Int J Neurosci. 2021 131(8):745-754.
PubMed: 32308094 DOI: 10.1080/00207454.2020.1754211
659 Turkez H, Cacciatore I, Marinelli L, Fornasari E, Aslan ME, Cadirci K, Kahraman CY, Caglar O, Tatar A, Di Biase G, Hacimuftuoglu A, Di Stefano A, Mardinoglu A.
Glycyl-L-Prolyl-L-Glutamate Pseudotripeptides for Treatment of Alzheimer's Disease.
Biomolecules. 2021 11(1):.
PubMed: 33478054 DOI: 10.3390/biom11010126
658 Andersson L, Cinato M, Mardani I, Miljanovic A, Arif M, Koh A, Lindbom M, Laudette M, Bollano E, Omerovic E, Klevstig M, Henricsson M, Fogelstrand P, Swärd K, Ekstrand M, Levin M, Wikström J, Doran S, Hyötyläinen T, Sinisalu L, Orešič M, Tivesten Å, Adiels M, Bergo MO, Proia R, Mardinoglu A, Jeppsson A, Borén J, Levin MC.
Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking.
Eur Heart J. 2021 Epub ahead of print
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657 Zhang C, Wei Y, Mardinoglu A, Zhang P.
Editorial: Application of Systems Biology in Molecular Characterization and Diagnosis of Cancer.
Front Mol Biosci. 2021 8():668146.
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656 Li X, Kim W, Arif M, Gao C, Hober A, Kotol D, Strandberg L, Forsström B, Sivertsson Å, Oksvold P, Turkez H, Grøtli M, Sato Y, Kume H, Ogawa S, Boren J, Nielsen J, Uhlen M, Zhang C, Mardinoglu A.
Discovery of Functional Alternatively Spliced Transcripts in Human Cancers.
Cancers (Basel). 2021 13(2):.
PubMed: 33478099 DOI: 10.3390/cancers13020348
655 Özdemir Ö, Marinelli L, Cacciatore I, Ciulla M, Emsen B, Di Stefano A, Mardinoglu A, Turkez H.
Anticancer effects of novel NSAIDs derivatives on cultured human glioblastoma cells.
Z Naturforsch C J Biosci. 2021 76(7-8):329-335.
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654 Lam S, Doran S, Yuksel HH, Altay O, Turkez H, Nielsen J, Boren J, Uhlen M, Mardinoglu A.
Addressing the heterogeneity in liver diseases using biological networks.
Brief Bioinform. 2021 22(2):1751-1766.
PubMed: 32201876 DOI: 10.1093/bib/bbaa002
653 Harzandi A, Lee S, Bidkhori G, Saha S, Hendry BM, Mardinoglu A, Shoaie S, Sharpe CC.
Acute kidney injury leading to CKD is associated with a persistence of metabolic dysfunction and hypertriglyceridemia.
iScience. 2021 24(2):102046.
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652 Karlsson M, Zhang C, Méar L, Zhong W, Digre A, Katona B, Sjöstedt E, Butler L, Odeberg J, Dusart P, Edfors F, Oksvold P, von Feilitzen K, Zwahlen M, Arif M, Altay O, Li X, Ozcan M, Mardinoglu A, Fagerberg L, Mulder J, Luo Y, Ponten F, Uhlén M, Lindskog C.
A single-cell type transcriptomics map of human tissues.
Sci Adv. 2021 7(31):.
PubMed: 34321199 DOI: 10.1126/sciadv.abh2169
651 Turanli B, Altay O, Borén J, Turkez H, Nielsen J, Uhlen M, Arga KY, Mardinoglu A.
Systems biology based drug repositioning for development of cancer therapy.
Semin Cancer Biol. 2021 68():47-58.
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650 Signorelli M, Ayoglu B, Johansson C, Lochmüller H, Straub V, Muntoni F, Niks E, Tsonaka R, Persson A, Aartsma-Rus A, Nilsson P, Al-Khalili Szigyarto C, Spitali P.
Longitudinal serum biomarker screening identifies malate dehydrogenase 2 as candidate prognostic biomarker for Duchenne muscular dystrophy.
J Cachexia Sarcopenia Muscle. 2020 11(2):505-517.
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649 Strandberg K, Ayoglu B, Roos A, Reza M, Niks E, Signorelli M, Fasterius E, Pontén F, Lochmüller H, Domingos J, Ala P, Muntoni F, Aartsma-Rus A, Spitali P, Nilsson P, Szigyarto CA.
Blood-derived biomarkers correlate with clinical progression in Duchenne muscular dystrophy.
J Neuromuscul Dis. 2020 7(3):231-246.
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648 Remnestål J, Öijerstedt L, Ullgren A, Olofsson J, Bergström S, Kultima K, Ingelsson M, Kilander L, Uhlén M, Månberg A, Graff C, Nilsson P.
Altered levels of CSF proteins in patients with FTD, presymptomatic mutation carriers and non-carriers.
Transl Neurodegener. 2020 9(1):27.
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647 Lourido L, Ruiz-Romero C, Picchi F, Diz-Rosales N, Vilaboa-Galán S, Fernández-López C, Tasende JAP, Pérez-Pampín E, Regueiro C, Mera-Varela A, Gonzalez A, Hambardzumyan K, Saevarsdottir S, Nilsson P, Blanco FJ.
Association of serum anti-centromere protein F antibodies with clinical response to infliximab in patients with rheumatoid arthritis: A prospective study.
Semin Arthritis Rheum. 2020 50(5):1101-1108.
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646 Rudberg AS, Havervall S, Månberg A, Jernbom Falk A, Aguilera K, Ng H, Gabrielsson L, Salomonsson AC, Hanke L, Murrell B, McInerney G, Olofsson J, Andersson E, Hellström C, Bayati S, Bergström S, Pin E, Sjöberg R, Tegel H, Hedhammar M, Phillipson M, Nilsson P, Hober S, Thålin C.
SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden.
Nat Commun. 2020 11(1):5064.
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645 Markaki I, Bergström S, Tsitsi P, Remnestål J, Månberg A, Hertz E, Paslawski W, Sorjonen K, Uhlén M, Mangone G, Carvalho S, Rascol O, Meissner WG, Magnin E, Wüllner U, Corvol JC, Nilsson P, Svenningsson P.
Cerebrospinal Fluid Levels of Kininogen-1 Indicate Early Cognitive Impairment in Parkinson's Disease.
Mov Disord. 2020 35(11):2101-2106.
PubMed: 33179332 DOI: 10.1002/mds.28192
644 Gaudenzi G, Kumbakumba E, Rasti R, Nanjebe D, Réu P, Nyehangane D, Mårtensson A, Nassejje M, Karlsson J, Mzee J, Nilsson P, Businge S, Loh E, Boum Ii Y, Andersson-Svahn H, Gantelius J, Mwanga-Amumpaire J, Alfvén T.
Point-of-Care Approaches for Meningitis Diagnosis in a Low-Resource Setting (Southwestern Uganda): Observational Cohort Study Protocol of the "PI-POC" Trial.
JMIR Res Protoc. 2020 9(11):e21430.
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643 Just D, Månberg A, Mitsios N, Stockmeier CA, Rajkowska G, Uhlén M, Mulder J, Feuk L, Cunningham JL, Nilsson P, Carlström EL.
Exploring autoantibody signatures in brain tissue from patients with severe mental illness.
Transl Psychiatry. 2020 10(1):401.
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642 Çadirci K, Özdemir Tozlu Ö, Türkez H, Mardinoğlu A.
The in vitro cytotoxic, genotoxic, and oxidative damage potentials of the oral artificial sweetener aspartame on cultured human blood cells
Turk J Med Sci. 2020 50(2):448-454.
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641 Zhang C, Bjornson E, Arif M, Tebani A, Lovric A, Benfeitas R, Ozcan M, Juszczak K, Kim W, Kim JT, Bidkhori G, Ståhlman M, Bergh PO, Adiels M, Turkez H, Taskinen MR, Bosley J, Marschall HU, Nielsen J, Uhlén M, Borén J, Mardinoglu A.
The acute effect of metabolic cofactor supplementation: a potential therapeutic strategy against non-alcoholic fatty liver disease.
Mol Syst Biol. 2020 16(4):e9495.
PubMed: 32337855 DOI: 10.15252/msb.209495
640 Rosario D, Boren J, Uhlen M, Proctor G, Aarsland D, Mardinoglu A, Shoaie S.
Systems Biology Approaches to Understand the Host-Microbiome Interactions in Neurodegenerative Diseases.
Front Neurosci. 2020 14():716.
PubMed: 32733199 DOI: 10.3389/fnins.2020.00716
639 Chapman MA, Arif M, Emanuelsson EB, Reitzner SM, Lindholm ME, Mardinoglu A, Sundberg CJ.
Skeletal Muscle Transcriptomic Comparison between Long-Term Trained and Untrained Men and Women.
Cell Rep. 2020 31(12):107808.
PubMed: 32579934 DOI: 10.1016/j.celrep.2020.107808
638 Pagoni A, Marinelli L, Di Stefano A, Ciulla M, Turkez H, Mardinoglu A, Vassiliou S, Cacciatore I.
Novel anti-Alzheimer phenol-lipoyl hybrids: Synthesis, physico-chemical characterization, and biological evaluation.
Eur J Med Chem. 2020 186():111880.
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637 Küçükdoğru R, Türkez H, Arslan ME, Tozlu ÖÖ, Sönmez E, Mardinoğlu A, Cacciatore I, Di Stefano A.
Neuroprotective effects of boron nitride nanoparticles in the experimental Parkinson's disease model against MPP+ induced apoptosis.
Metab Brain Dis. 2020 35(6):947-957.
PubMed: 32215836 DOI: 10.1007/s11011-020-00559-6
636 Lieven C, Beber ME, Olivier BG, Bergmann FT, Ataman M, Babaei P, Bartell JA, Blank LM, Chauhan S, Correia K, Diener C, Dräger A, Ebert BE, Edirisinghe JN, Faria JP, Feist AM, Fengos G, Fleming RMT, García-Jiménez B, Hatzimanikatis V, van Helvoirt W, Henry CS, Hermjakob H, Herrgård MJ, Kaafarani A, Kim HU, King Z, Klamt S, Klipp E, Koehorst JJ, König M, Lakshmanan M, Lee DY, Lee SY, Lee S, Lewis NE, Liu F, Ma H, Machado D, Mahadevan R, Maia P, Mardinoglu A, Medlock GL, Monk JM, Nielsen J, Nielsen LK, Nogales J, Nookaew I, Palsson BO, Papin JA, Patil KR, Poolman M, Price ND, Resendis-Antonio O, Richelle A, Rocha I, Sánchez BJ, Schaap PJ, Malik Sheriff RS, Shoaie S, Sonnenschein N, Teusink B, Vilaça P, Vik JO, Wodke JAH, Xavier JC, Yuan Q, Zakhartsev M, Zhang C.
MEMOTE for standardized genome-scale metabolic model testing.
Nat Biotechnol. 2020 38(3):272-276.
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635 Zhan C, Bidkhori G, Schwarz H, Malm M, Mebrahtu A, Field R, Sellick C, Hatton D, Varley P, Mardinoglu A, Rockberg J, Chotteau V.
Low Shear Stress Increases Recombinant Protein Production and High Shear Stress Increases Apoptosis in Human Cells.
iScience. 2020 23(11):101653.
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634 Ozcan M, Altay O, Lam S, Turkez H, Aksoy Y, Nielsen J, Uhlen M, Boren J, Mardinoglu A.
Improvement in the Current Therapies for Hepatocellular Carcinoma Using a Systems Medicine Approach.
Adv Biosyst. 2020 4(6):e2000030.
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633 Turkez H, Cacciatore I, Arslan ME, Fornasari E, Marinelli L, Di Stefano A, Mardinoglu A.
Histidyl-Proline Diketopiperazine Isomers as Multipotent Anti-Alzheimer Drug Candidates.
Biomolecules. 2020 10(5):.
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632 Larsson I, Uhlén M, Zhang C, Mardinoglu A.
Genome-Scale Metabolic Modeling of Glioblastoma Reveals Promising Targets for Drug Development.
Front Genet. 2020 11():381.
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631 Sinha M, Mardinoglu A, Ghose J, Singh K.
Editorial: Redox Homeostasis and Cancer.
Oxid Med Cell Longev. 2020 2020():5487381.
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630 Beklen H, Gulfidan G, Arga KY, Mardinoglu A, Turanli B.
Drug Repositioning for P-Glycoprotein Mediated Co-Expression Networks in Colorectal Cancer.
Front Oncol. 2020 10():1273.
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629 Altay O, Mohammadi E, Lam S, Turkez H, Boren J, Nielsen J, Uhlen M, Mardinoglu A.
Current Status of COVID-19 Therapies and Drug Repositioning Applications.
iScience. 2020 23(7):101303.
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628 Li X, Turanli B, Juszczak K, Kim W, Arif M, Sato Y, Ogawa S, Turkez H, Nielsen J, Boren J, Uhlen M, Zhang C, Mardinoglu A.
Classification of clear cell renal cell carcinoma based on alternative splicing.
Heliyon. 2020 6(2):e03440.
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627 Sayitoglu EC, Georgoudaki AM, Chrobok M, Ozkazanc D, Josey BJ, Arif M, Kusser K, Hartman M, Chinn TM, Potens R, Pamukcu C, Krueger R, Zhang C, Mardinoglu A, Alici E, Temple HT, Sutlu T, Duru AD.
Boosting Natural Killer Cell-Mediated Targeting of Sarcoma Through DNAM-1 and NKG2D.
Front Immunol. 2020 11():40.
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626 Mohammadi E, Benfeitas R, Turkez H, Boren J, Nielsen J, Uhlen M, Mardinoglu A.
Applications of Genome-Wide Screening and Systems Biology Approaches in Drug Repositioning.
Cancers (Basel). 2020 12(9):.
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625 Robinson JL, Kocabaş P, Wang H, Cholley PE, Cook D, Nilsson A, Anton M, Ferreira R, Domenzain I, Billa V, Limeta A, Hedin A, Gustafsson J, Kerkhoven EJ, Svensson LT, Palsson BO, Mardinoglu A, Hansson L, Uhlén M, Nielsen J.
An atlas of human metabolism.
Sci Signal. 2020 13(624):.
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624 Choi MJ, Jung SB, Lee SE, Kang SG, Lee JH, Ryu MJ, Chung HK, Chang JY, Kim YK, Hong HJ, Kim H, Kim HJ, Lee CH, Mardinoglu A, Yi HS, Shong M.
An adipocyte-specific defect in oxidative phosphorylation increases systemic energy expenditure and protects against diet-induced obesity in mouse models.
Diabetologia. 2020 63(4):837-852.
PubMed: 31925461 DOI: 10.1007/s00125-019-05082-7
623 Rawshani A, Eliasson B, Rawshani A, Henninger J, Mardinoglu A, Carlsson Å, Sohlin M, Ljungberg M, Hammarstedt A, Rosengren A, Smith U.
Adipose tissue morphology, imaging and metabolomics predicting cardiometabolic risk and family history of type 2 diabetes in non-obese men.
Sci Rep. 2020 10(1):9973.
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622 Sivertsson Å, Lindström E, Oksvold P, Katona B, Hikmet F, Vuu J, Gustavsson J, Sjöstedt E, von Feilitzen K, Kampf C, Schwenk JM, Uhlén M, Lindskog C.
Enhanced Validation of Antibodies Enables the Discovery of Missing Proteins.
J Proteome Res. 2020 Epub ahead of print
PubMed: 33170010 DOI: 10.1021/acs.jproteome.0c00486
621 Dodig-Crnković T, Hong MG, Thomas CE, Häussler RS, Bendes A, Dale M, Edfors F, Forsström B, Magnusson PKE, Schuppe-Koistinen I, Odeberg J, Fagerberg L, Gummesson A, Bergström G, Uhlén M, Schwenk JM.
Facets of individual-specific health signatures determined from longitudinal plasma proteome profiling.
EBioMedicine. 2020 57():102854.
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620 Hong MG, Dodig-Crnković T, Chen X, Drobin K, Lee W, Wang Y, Edfors F, Kotol D, Thomas CE, Sjöberg R, Odeberg J, Hamsten A, Silveira A, Hall P, Nilsson P, Pawitan Y, Uhlén M, Pedersen NL, Hägg S, Magnusson PK, Schwenk JM.
Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortality.
Life Sci Alliance. 2020 3(10):.
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619 Zhong W, Gummesson A, Tebani A, Karlsson MJ, Hong MG, Schwenk JM, Edfors F, Bergström G, Fagerberg L, Uhlén M.
Whole-genome sequence association analysis of blood proteins in a longitudinal wellness cohort.
Genome Med. 2020 12(1):53.
PubMed: 32576278 DOI: 10.1186/s13073-020-00755-0
618 Dezfouli M, Bergström S, Skattum L, Abolhassani H, Neiman M, Torabi-Rahvar M, Franco Jarava C, Martin-Nalda A, Ferrer Balaguer JM, Slade CA, Roos A, Fernandez Pereira LM, López-Trascasa M, Gonzalez-Granado LI, Allende-Martinez LM, Mizuno Y, Yoshida Y, Friman V, Lundgren Å, Aghamohammadi A, Rezaei N, Hernández-Gonzalez M, von Döbeln U, Truedsson L, Hara T, Nonoyama S, Schwenk JM, Nilsson P, Hammarström L.
Newborn Screening for Presymptomatic Diagnosis of Complement and Phagocyte Deficiencies.
Front Immunol. 2020 11():455.
PubMed: 32256498 DOI: 10.3389/fimmu.2020.00455
617 Drobin K, Marczyk M, Halle M, Danielsson D, Papiez A, Sangsuwan T, Bendes A, Hong MG, Qundos U, Harms-Ringdahl M, Wersäll P, Polanska J, Schwenk JM, Haghdoost S.
Molecular Profiling for Predictors of Radiosensitivity in Patients with Breast or Head-and-Neck Cancer.
Cancers (Basel). 2020 12(3):.
PubMed: 32235817 DOI: 10.3390/cancers12030753
616 Suhre K, McCarthy MI, Schwenk JM.
Genetics meets proteomics: perspectives for large population-based studies.
Nat Rev Genet. 2020 Epub ahead of print
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615 Lyu C, Lyu GW, Mulder J, Uhlén M, Cai XH, Hökfelt T, Sten Shi TJ.
Expression and regulation of FRMD6 in mouse DRG neurons and spinal cord after nerve injury.
Sci Rep. 2020 10(1):1880.
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614 Lyu C, Lyu GW, Mulder J, Martinez A, Shi TS.
G Protein-Gated Inwardly Rectifying Potassium Channel Subunit 3 is Upregulated in Rat DRGs and Spinal Cord After Peripheral Nerve Injury.
J Pain Res. 2020 13():419-429.
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613 Ehrenberg AJ, Morales DO, Piergies AMH, Li SH, Tejedor JS, Mladinov M, Mulder J, Grinberg LT.
A manual multiplex immunofluorescence method for investigating neurodegenerative diseases.
J Neurosci Methods. 2020 339():108708.
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612 Farfaras S, Roshani L, Mulder J, Mitsios N, Hallström EK, Kartus JT.
Increased levels of inflammatory markers in the subscapularis tendon and joint capsule in patients with subacromial impingement.
Knee Surg Sports Traumatol Arthrosc. 2020 Epub ahead of print
PubMed: 32356046 DOI: 10.1007/s00167-020-05992-9
611 Little PV, Arnberg F, Jussing E, Lu L, Ingemann Jensen A, Mitsios N, Mulder J, Tran TA, Holmin S.
The cellular basis of increased PET hypoxia tracer uptake in focal cerebral ischemia with comparison between [F]FMISO and [Cu]CuATSM.
J Cereb Blood Flow Metab. 2020 ():271678X20923857.
PubMed: 32423333 DOI: 10.1177/0271678X20923857
610 Morin E, Lindskog C, Johansson M, Egevad L, Sandström P, Harmenberg U, Claesson-Welsh L, Sjöberg E.
Perivascular Neuropilin-1 expression is an independent marker of improved survival in renal cell carcinoma.
J Pathol. 2020 250(4):387-396.
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609 Ström P, Kartasalo K, Olsson H, Solorzano L, Delahunt B, Berney DM, Bostwick DG, Evans AJ, Grignon DJ, Humphrey PA, Iczkowski KA, Kench JG, Kristiansen G, van der Kwast TH, Leite KRM, McKenney JK, Oxley J, Pan CC, Samaratunga H, Srigley JR, Takahashi H, Tsuzuki T, Varma M, Zhou M, Lindberg J, Lindskog C, Ruusuvuori P, Wählby C, Grönberg H, Rantalainen M, Egevad L, Eklund M.
Artificial intelligence for diagnosis and grading of prostate cancer in biopsies: a population-based, diagnostic study.
Lancet Oncol. 2020 21(2):222-232.
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608 Guo J, Nie X, Giebler M, Mlcochova H, Wang Y, Grow EJ, DonorConnect, Kim R, Tharmalingam M, Matilionyte G, Lindskog C, Carrell DT, Mitchell RT, Goriely A, Hotaling JM, Cairns BR.
The Dynamic Transcriptional Cell Atlas of Testis Development during Human Puberty.
Cell Stem Cell. 2020 26(2):262-276.e4.
PubMed: 31928944 DOI: 10.1016/j.stem.2019.12.005
607 Niinivirta M, Georganaki M, Enblad G, Lindskog C, Dimberg A, Ullenhag GJ.
Tumor endothelial ELTD1 as a predictive marker for treatment of renal cancer patients with sunitinib.
BMC Cancer. 2020 20(1):339.
PubMed: 32321460 DOI: 10.1186/s12885-020-06770-z
606 Miyashita N, Horie M, Mikami Y, Urushiyama H, Fukuda K, Miyakawa K, Matsuzaki H, Makita K, Morishita Y, Harada H, Backman M, Lindskog C, Brunnström H, Micke P, Nagase T, Saito A.
ASCL1 promotes tumor progression through cell-autonomous signaling and immune modulation in a subset of lung adenocarcinoma.
Cancer Lett. 2020 489():121-132.
PubMed: 32534174 DOI: 10.1016/j.canlet.2020.06.002
605 Lindskog C, Backman M, Zieba A, Asplund A, Uhlén M, Landegren U, Pontén F.
Proximity Ligation Assay as a Tool for Antibody Validation in Human Tissues.
J Histochem Cytochem. 2020 68(7):515-529.
PubMed: 32602410 DOI: 10.1369/0022155420936384
604 Ali AS, Perren A, Lindskog C, Welin S, Sorbye H, Grönberg M, Janson ET.
Candidate protein biomarkers in pancreatic neuroendocrine neoplasms grade 3.
Sci Rep. 2020 10(1):10639.
PubMed: 32606315 DOI: 10.1038/s41598-020-67670-7
603 Ambroise G, Yu TT, Zhang B, Kacal M, Hao Y, Queiroz AL, Ouchida AT, Lindskog C, Norberg E, Vakifahmetoglu-Norberg H.
Systematic analysis reveals a functional role for STAMBPL1 in the epithelial-mesenchymal transition process across multiple carcinomas.
Br J Cancer. 2020 123(7):1164-1177.
PubMed: 32636467 DOI: 10.1038/s41416-020-0972-x
602 Hikmet F, Méar L, Edvinsson Å, Micke P, Uhlén M, Lindskog C.
The protein expression profile of ACE2 in human tissues.
Mol Syst Biol. 2020 16(7):e9610.
PubMed: 32715618 DOI: 10.15252/msb.20209610
601 Omenn GS, Lane L, Overall CM, Cristea IM, Corrales FJ, Lindskog C, Paik YK, Van Eyk JE, Liu S, Pennington SR, Snyder MP, Baker MS, Bandeira N, Aebersold R, Moritz RL, Deutsch EW.
Research on the Human Proteome Reaches a Major Milestone: >90% of Predicted Human Proteins Now Credibly Detected, According to the HUPO Human Proteome Project.
J Proteome Res. 2020 Epub ahead of print
PubMed: 32931287 DOI: 10.1021/acs.jproteome.0c00485
600 Danielsson F, Mahdessian D, Axelsson U, Sullivan D, Uhlén M, Andersen JS, Thul PJ, Lundberg E.
Spatial Characterization of the Human Centrosome Proteome Opens Up New Horizons for a Small but Versatile Organelle.
Proteomics. 2020 ():e1900361.
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599 Bäckström A, Kugel L, Gnann C, Xu H, Aslan JE, Lundberg E, Stadler C.
A Sample Preparation Protocol for High Throughput Immunofluorescence of Suspension Cells on an Adherent Surface.
J Histochem Cytochem. 2020 68(7):473-489.
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598 Stenström L, Mahdessian D, Gnann C, Cesnik AJ, Ouyang W, Leonetti MD, Uhlén M, Cuylen-Haering S, Thul PJ, Lundberg E.
Mapping the nucleolar proteome reveals a spatiotemporal organization related to intrinsic protein disorder.
Mol Syst Biol. 2020 16(8):e9469.
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597 Adhikari S, Nice EC, Deutsch EW, Lane L, Omenn GS, Pennington SR, Paik YK, Overall CM, Corrales FJ, Cristea IM, Van Eyk JE, Uhlén M, Lindskog C, Chan DW, Bairoch A, Waddington JC, Justice JL, LaBaer J, Rodriguez H, He F, Kostrzewa M, Ping P, Gundry RL, Stewart P, Srivastava S, Srivastava S, Nogueira FCS, Domont GB, Vandenbrouck Y, Lam MPY, Wennersten S, Vizcaino JA, Wilkins M, Schwenk JM, Lundberg E, Bandeira N, Marko-Varga G, Weintraub ST, Pineau C, Kusebauch U, Moritz RL, Ahn SB, Palmblad M, Snyder MP, Aebersold R, Baker MS.
A high-stringency blueprint of the human proteome.
Nat Commun. 2020 11(1):5301.
PubMed: 33067450 DOI: 10.1038/s41467-020-19045-9
596 Ghoshal B., Lindskog C., Tucker A.
Estimating Uncertainty in Deep Learning for Reporting Confidence: An Application on Cell Type Prediction in Testes Based on Proteomics.
Advances in Intelligent Data Analysis XVIII. IDA 2020. 2020 223-234
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595 Tebani A, Gummesson A, Zhong W, Koistinen IS, Lakshmikanth T, Olsson LM, Boulund F, Neiman M, Stenlund H, Hellström C, Karlsson MJ, Arif M, Dodig-Crnković T, Mardinoglu A, Lee S, Zhang C, Chen Y, Olin A, Mikes J, Danielsson H, von Feilitzen K, Jansson PA, Angerås O, Huss M, Kjellqvist S, Odeberg J, Edfors F, Tremaroli V, Forsström B, Schwenk JM, Nilsson P, Moritz T, Bäckhed F, Engstrand L, Brodin P, Bergström G, Uhlen M, Fagerberg L.
Integration of molecular profiles in a longitudinal wellness profiling cohort.
Nat Commun. 2020 11(1):4487.
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594 Sjöstedt E, Zhong W, Fagerberg L, Karlsson M, Mitsios N, Adori C, Oksvold P, Edfors F, Limiszewska A, Hikmet F, Huang J, Du Y, Lin L, Dong Z, Yang L, Liu X, Jiang H, Xu X, Wang J, Yang H, Bolund L, Mardinoglu A, Zhang C, von Feilitzen K, Lindskog C, Pontén F, Luo Y, Hökfelt T, Uhlén M, Mulder J.
An atlas of the protein-coding genes in the human, pig, and mouse brain.
Science. 2020 367(6482)
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593 Dusart P, Hallström BM, Renné T, Odeberg J, Uhlén M, Butler LM.
A Systems-Based Map of Human Brain Cell-Type Enriched Genes and Malignancy-Associated Endothelial Changes.
Cell Rep. 2019 29(6):1690-1706.e4.
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592 Ruiz-Romero C, Lam MPY, Nilsson P, Önnerfjord P, Utz PJ, Van Eyk JE, Venkatraman V, Fert-Bober J, Watt FE, Blanco FJ.
Mining the Proteome Associated with Rheumatic and Autoimmune Diseases.
J Proteome Res. 2019 18(12):4231-4239.
PubMed: 31599600 DOI: 10.1021/acs.jproteome.9b00360
591 Sahebekhtiari N, Saraswat M, Joenväärä S, Jokinen R, Lovric A, Kaye S, Mardinoglu A, Rissanen A, Kaprio J, Renkonen R, Pietiläinen KH.
Plasma Proteomics Analysis Reveals Dysregulation of Complement Proteins and Inflammation in Acquired Obesity-A Study on Rare BMI-Discordant Monozygotic Twin Pairs.
Proteomics Clin Appl. 2019 13(4):e1800173.
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590 Zhang C, Aldrees M, Arif M, Li X, Mardinoglu A, Aziz MA.
Elucidating the Reprograming of Colorectal Cancer Metabolism Using Genome-Scale Metabolic Modeling.
Front Oncol. 2019 9():681.
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589 Lundgren S, Fagerström-Vahman H, Zhang C, Ben-Dror L, Mardinoglu A, Uhlen M, Nodin B, Jirström K.
Discovery of KIRREL as a biomarker for prognostic stratification of patients with thin melanoma.
Biomark Res. 2019 7():1.
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588 Benfeitas R, Bidkhori G, Mukhopadhyay B, Klevstig M, Arif M, Zhang C, Lee S, Cinar R, Nielsen J, Uhlen M, Boren J, Kunos G, Mardinoglu A.
Characterization of heterogeneous redox responses in hepatocellular carcinoma patients using network analysis.
EBioMedicine. 2019 40():471-487.
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587 Liu Z, Zhang C, Lee S, Kim W, Klevstig M, Harzandi AM, Sikanic N, Arif M, Ståhlman M, Nielsen J, Uhlen M, Boren J, Mardinoglu A.
Pyruvate kinase L/R is a regulator of lipid metabolism and mitochondrial function.
Metab Eng. 2019 52():263-272.
PubMed: 30615941 DOI: 10.1016/j.ymben.2019.01.001
586 Svensson MC, Borg D, Zhang C, Hedner C, Nodin B, Uhlén M, Mardinoglu A, Leandersson K, Jirström K.
Expression of PD-L1 and PD-1 in Chemoradiotherapy-Naïve Esophageal and Gastric Adenocarcinoma: Relationship With Mismatch Repair Status and Survival.
Front Oncol. 2019 9():136.
PubMed: 30931254 DOI: 10.3389/fonc.2019.00136
585 Turanli B, Zhang C, Kim W, Benfeitas R, Uhlen M, Arga KY, Mardinoglu A.
Discovery of therapeutic agents for prostate cancer using genome-scale metabolic modeling and drug repositioning.
EBioMedicine. 2019 42():386-396.
PubMed: 30905848 DOI: 10.1016/j.ebiom.2019.03.009
584 Harms MJ, Li Q, Lee S, Zhang C, Kull B, Hallen S, Thorell A, Alexandersson I, Hagberg CE, Peng XR, Mardinoglu A, Spalding KL, Boucher J.
Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes.
Cell Rep. 2019 27(1):213-225.e5.
PubMed: 30943403 DOI: 10.1016/j.celrep.2019.03.026
583 Turanli B, Karagoz K, Bidkhori G, Sinha R, Gatza ML, Uhlen M, Mardinoglu A, Arga KY.
Multi-Omic Data Interpretation to Repurpose Subtype Specific Drug Candidates for Breast Cancer.
Front Genet. 2019 10():420.
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582 Mardinoglu A, Ural D, Zeybel M, Yuksel HH, Uhlén M, Borén J.
The Potential Use of Metabolic Cofactors in Treatment of NAFLD.
Nutrients. 2019 11(7):.
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581 Altay O, Nielsen J, Uhlen M, Boren J, Mardinoglu A.
Systems biology perspective for studying the gut microbiota in human physiology and liver diseases.
EBioMedicine. 2019 49():364-373.
PubMed: 31636011 DOI: 10.1016/j.ebiom.2019.09.057
580 Klevstig M, Arif M, Mannila M, Svedlund S, Mardani I, Ståhlman M, Andersson L, Lindbom M, Miljanovic A, Franco-Cereceda A, Eriksson P, Jeppsson A, Gan LM, Levin M, Mardinoglu A, Ehrenborg E, Borén J.
Cardiac expression of the microsomal triglyceride transport protein protects the heart function during ischemia.
J Mol Cell Cardiol. 2019 137():1-8.
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579 Dawed AY, Zhou K, van Leeuwen N, Mahajan A, Robertson N, Koivula R, Elders PJM, Rauh SP, Jones AG, Holl RW, Stingl JC, Franks PW, McCarthy MI, 't Hart LM, Pearson ER, IMI DIRECT Consortium.
Variation in the Plasma Membrane Monoamine Transporter (PMAT) (Encoded by ) and Organic Cation Transporter 1 (OCT1) (Encoded by ) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study.
Diabetes Care. 2019 42(6):1027-1033.
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578 Lorenzen E, Dodig-Crnković T, Kotliar IB, Pin E, Ceraudo E, Vaughan RD, Uhlèn M, Huber T, Schwenk JM, Sakmar TP.
Multiplexed analysis of the secretin-like GPCR-RAMP interactome.
Sci Adv. 2019 5(9):eaaw2778.
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577 Ignjatovic V, Geyer PE, Palaniappan KK, Chaaban JE, Omenn GS, Baker MS, Deutsch EW, Schwenk JM.
Mass Spectrometry-Based Plasma Proteomics: Considerations from Sample Collection to Achieving Translational Data.
J Proteome Res. 2019 18(12):4085-4097.
PubMed: 31573204 DOI: 10.1021/acs.jproteome.9b00503
576 Svedberg MM, Varnäs K, Varrone A, Mitsios N, Mulder J, Gulyás B, Beaumont V, Munoz-Sanjuan I, Zaleska MM, Schmidt CJ, Halldin C, Mrzljak L.
In vitro phosphodiesterase 10A (PDE10A) binding in whole hemisphere human brain using the PET radioligand [F]MNI-659.
Brain Res. 2019 1711():140-145.
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575 Zhao Z, Kurimchak A, Nikonova AS, Feiser F, Wasserman JS, Fowle H, Varughese T, Connors M, Johnson K, Makhov P, Lindskog C, Kolenko VM, Golemis EA, Duncan JS, Graña X.
PPP2R2A prostate cancer haploinsufficiency is associated with worse prognosis and a high vulnerability to B55α/PP2A reconstitution that triggers centrosome destabilization.
Oncogenesis. 2019 8(12):72.
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574 Ouyang W, Mueller F, Hjelmare M, Lundberg E, Zimmer C.
ImJoy: an open-source computational platform for the deep learning era.
Nat Methods. 2019 16(12):1199-1200.
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573 Ouyang W, Winsnes CF, Hjelmare M, Cesnik AJ, Åkesson L, Xu H, Sullivan DP, Dai S, Lan J, Jinmo P, Galib SM, Henkel C, Hwang K, Poplavskiy D, Tunguz B, Wolfinger RD, Gu Y, Li C, Xie J, Buslov D, Fironov S, Kiselev A, Panchenko D, Cao X, Wei R, Wu Y, Zhu X, Tseng KL, Gao Z, Ju C, Yi X, Zheng H, Kappel C, Lundberg E.
Analysis of the Human Protein Atlas Image Classification competition.
Nat Methods. 2019 16(12):1254-1261.
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572 Uhlen M, Karlsson MJ, Zhong W, Tebani A, Pou C, Mikes J, Lakshmikanth T, Forsström B, Edfors F, Odeberg J, Mardinoglu A, Zhang C, von Feilitzen K, Mulder J, Sjöstedt E, Hober A, Oksvold P, Zwahlen M, Ponten F, Lindskog C, Sivertsson Å, Fagerberg L, Brodin P.
A genome-wide transcriptomic analysis of protein-coding genes in human blood cells.
Science. 2019 366(6472)
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571 Uhlén M, Karlsson MJ, Hober A, Svensson AS, Scheffel J, Kotol D, Zhong W, Tebani A, Strandberg L, Edfors F, Sjöstedt E, Mulder J, Mardinoglu A, Berling A, Ekblad S, Dannemeyer M, Kanje S, Rockberg J, Lundqvist M, Malm M, Volk AL, Nilsson P, Månberg A, Dodig-Crnkovic T, Pin E, Zwahlen M, Oksvold P, von Feilitzen K, Häussler RS, Hong MG, Lindskog C, Ponten F, Katona B, Vuu J, Lindström E, Nielsen J, Robinson J, Ayoglu B, Mahdessian D, Sullivan D, Thul P, Danielsson F, Stadler C, Lundberg E, Bergström G, Gummesson A, Voldborg BG, Tegel H, Hober S, Forsström B, Schwenk JM, Fagerberg L, Sivertsson Å.
The human secretome.
Sci Signal. 2019 12(609)
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570 Koivula RW, Forgie IM, Kurbasic A, Viñuela A, Heggie A, Giordano GN, Hansen TH, Hudson M, Koopman ADM, Rutters F, Siloaho M, Allin KH, Brage S, Brorsson CA, Dawed AY, De Masi F, Groves CJ, Kokkola T, Mahajan A, Perry MH, Rauh SP, Ridderstråle M, Teare HJA, Thomas EL, Tura A, Vestergaard H, White T, Adamski J, Bell JD, Beulens JW, Brunak S, Dermitzakis ET, Froguel P, Frost G, Gupta R, Hansen T, Hattersley A, Jablonka B, Kaye J, Laakso M, McDonald TJ, Pedersen O, Schwenk JM, Pavo I, Mari A, McCarthy MI, Ruetten H, Walker M, Pearson E, Franks PW, IMI DIRECT Consortium.
Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium.
Diabetologia. 2019 62(9):1601-1615.
PubMed: 31203377 DOI: 10.1007/s00125-019-4906-1
569 Elfving H, Mattsson JSM, Lindskog C, Backman M, Menzel U, Micke P.
Programmed Cell Death Ligand 1 Immunohistochemistry: A Concordance Study Between Surgical Specimen, Biopsy, and Tissue Microarray.
Clin Lung Cancer. 2019 20(4):258-262.e1.
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568 Pineau C, Hikmet F, Zhang C, Oksvold P, Chen S, Fagerberg L, Uhlén M, Lindskog C.
Cell Type-Specific Expression of Testis Elevated Genes Based on Transcriptomics and Antibody-Based Proteomics.
J Proteome Res. 2019 18(12):4215-4230.
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567 Pin E, Sjöberg R, Andersson E, Hellström C, Olofsson J, Jernbom Falk A, Bergström S, Remnestål J, Just D, Nilsson P, Månberg A.
Array-Based Profiling of Proteins and Autoantibody Repertoires in CSF.
Methods Mol Biol. 2019 2044():303-318.
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566 Tengvall K, Huang J, Hellström C, Kammer P, Biström M, Ayoglu B, Lima Bomfim I, Stridh P, Butt J, Brenner N, Michel A, Lundberg K, Padyukov L, Lundberg IE, Svenungsson E, Ernberg I, Olafsson S, Dilthey AT, Hillert J, Alfredsson L, Sundström P, Nilsson P, Waterboer T, Olsson T, Kockum I.
Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk.
Proc Natl Acad Sci U S A. 2019 116(34):16955-16960.
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565 Idborg H, Zandian A, Ossipova E, Wigren E, Preger C, Mobarrez F, Checa A, Sohrabian A, Pucholt P, Sandling JK, Fernandes-Cerqueira C, Rönnelid J, Oke V, Grosso G, Kvarnström M, Larsson A, Wheelock CE, Syvänen AC, Rönnblom L, Kultima K, Persson H, Gräslund S, Gunnarsson I, Nilsson P, Svenungsson E, Jakobsson PJ.
Circulating Levels of Interferon Regulatory Factor-5 Associates With Subgroups of Systemic Lupus Erythematosus Patients.
Front Immunol. 2019 10():1029.
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564 Bedri SK, Nilsson OB, Fink K, Månberg A, Hamsten C, Ayoglu B, Manouchehrinia A, Nilsson P, Olsson T, Hillert J, Grönlund H, Glaser A.
Plasma protein profiling reveals candidate biomarkers for multiple sclerosis treatment.
PLoS One. 2019 14(5):e0217208.
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563 Neiman M, Hellström C, Just D, Mattsson C, Fagerberg L, Schuppe-Koistinen I, Gummesson A, Bergström G, Kallioniemi O, Achour A, Sallinen R, Uhlén M, Nilsson P.
Individual and stable autoantibody repertoires in healthy individuals.
Autoimmunity. 2019 52(1):1-11.
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562 Idborg H, Zandian A, Sandberg AS, Nilsson B, Elvin K, Truedsson L, Sohrabian A, Rönnelid J, Mo J, Grosso G, Kvarnström M, Gunnarsson I, Lehtiö J, Nilsson P, Svenungsson E, Jakobsson PJ.
Two subgroups in systemic lupus erythematosus with features of antiphospholipid or Sjögren's syndrome differ in molecular signatures and treatment perspectives.
Arthritis Res Ther. 2019 21(1):62.
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561 Mikus M, Johansson C, Acevedo N, Nilsson P, Scheynius A.
The antimicrobial protein S100A12 identified as a potential autoantigen in a subgroup of atopic dermatitis patients.
Clin Transl Allergy. 2019 9():6.
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560 Khoonsari PE, Shevchenko G, Herman S, Remnestål J, Giedraitis V, Brundin R, Degerman Gunnarsson M, Kilander L, Zetterberg H, Nilsson P, Lannfelt L, Ingelsson M, Kultima K.
Improved Differential Diagnosis of Alzheimer's Disease by Integrating ELISA and Mass Spectrometry-Based Cerebrospinal Fluid Biomarkers.
J Alzheimers Dis. 2019 67(2):639-651.
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559 Ge C, Xu B, Liang B, Lönnblom E, Lundström SL, Zubarev RA, Ayoglu B, Nilsson P, Skogh T, Kastbom A, Malmström V, Klareskog L, Toes REM, Rispens T, Dobritzsch D, Holmdahl R.
Structural Basis of Cross-Reactivity of Anti-Citrullinated Protein Antibodies.
Arthritis Rheumatol. 2019 71(2):210-221.
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558 Steen J, Forsström B, Sahlström P, Odowd V, Israelsson L, Krishnamurthy A, Badreh S, Mathsson Alm L, Compson J, Ramsköld D, Ndlovu W, Rapecki S, Hansson M, Titcombe PJ, Bang H, Mueller DL, Catrina AI, Grönwall C, Skriner K, Nilsson P, Lightwood D, Klareskog L, Malmström V.
Recognition of Amino Acid Motifs, Rather Than Specific Proteins, by Human Plasma Cell-Derived Monoclonal Antibodies to Posttranslationally Modified Proteins in Rheumatoid Arthritis.
Arthritis Rheumatol. 2019 71(2):196-209.
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557 Månberg A, Bradley F, Qundos U, Guthrie BL, Birse K, Noël-Romas L, Lindskog C, Bosire R, Kiarie J, Farquhar C, Burgener AD, Nilsson P, Broliden K.
A High-throughput Bead-based Affinity Assay Enables Analysis of Genital Protein Signatures in Women At Risk of HIV Infection.
Mol Cell Proteomics. 2019 18(3):461-476.
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556 Lundberg E, Borner GHH.
Spatial proteomics: a powerful discovery tool for cell biology.
Nat Rev Mol Cell Biol. 2019 20(5):285-302.
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555 Edlund K, Madjar K, Mattsson JSM, Djureinovic D, Lindskog C, Brunnström H, Koyi H, Brandén E, Jirström K, Pontén F, Rahnenführer J, Micke P, Hengstler JG.
Prognostic Impact of Tumor Cell Programmed Death Ligand 1 Expression and Immune Cell Infiltration in NSCLC.
J Thorac Oncol. 2019 14(4):628-640.
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554 Cadenas C, Vosbeck S, Edlund K, Grgas K, Madjar K, Hellwig B, Adawy A, Glotzbach A, Stewart JD, Lesjak MS, Franckenstein D, Claus M, Hayen H, Schriewer A, Gianmoena K, Thaler S, Schmidt M, Micke P, Pontén F, Mardinoglu A, Zhang C, Käfferlein HU, Watzl C, Frank S, Rahnenführer J, Marchan R, Hengstler JG.
LIPG-promoted lipid storage mediates adaptation to oxidative stress in breast cancer.
Int J Cancer. 2019 145(4):901-915.
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553 Wang D, Eraslan B, Wieland T, Hallström B, Hopf T, Zolg DP, Zecha J, Asplund A, Li LH, Meng C, Frejno M, Schmidt T, Schnatbaum K, Wilhelm M, Ponten F, Uhlen M, Gagneur J, Hahne H, Kuster B.
A deep proteome and transcriptome abundance atlas of 29 healthy human tissues.
Mol Syst Biol. 2019 15(2):e8503.
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552 Eraslan B, Wang D, Gusic M, Prokisch H, Hallström BM, Uhlén M, Asplund A, Pontén F, Wieland T, Hopf T, Hahne H, Kuster B, Gagneur J.
Quantification and discovery of sequence determinants of protein-per-mRNA amount in 29 human tissues.
Mol Syst Biol. 2019 15(2):e8513.
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551 Aasebø KØ, Dragomir A, Sundström M, Mezheyeuski A, Edqvist PH, Eide GE, Ponten F, Pfeiffer P, Glimelius B, Sorbye H.
Consequences of a high incidence of microsatellite instability and BRAF-mutated tumors: A population-based cohort of metastatic colorectal cancer patients.
Cancer Med. 2019 8(7):3623-3635.
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550 Mezheyeuski A, Hrynchyk I, Herrera M, Karlberg M, Osterman E, Ragnhammar P, Edler D, Portyanko A, Ponten F, Sjöblom T, Glimelius B, Östman A.
Stroma-normalised vessel density predicts benefit from adjuvant fluorouracil-based chemotherapy in patients with stage II/III colon cancer.
Br J Cancer. 2019 121(4):303-311.
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549 Niinivirta M, Enblad G, Lindskog C, Pontén F, Dragomir A, Ullenhag GJ.
Tumoral Pyruvate Kinase L/R as a Predictive Marker for the Treatment of Renal Cancer Patients with Sunitinib and Sorafenib.
J Cancer. 2019 10(14):3224-3231.
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548 Omenn GS, Lane L, Overall CM, Corrales FJ, Schwenk JM, Paik YK, Van Eyk JE, Liu S, Pennington S, Snyder MP, Baker MS, Deutsch EW.
Progress on Identifying and Characterizing the Human Proteome: 2019 Metrics from the HUPO Human Proteome Project.
J Proteome Res. 2019 18(12):4098-4107.
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547 Häussler RS, Bendes A, Iglesias M, Sanchez-Rivera L, Dodig-Crnković T, Byström S, Fredolini C, Birgersson E, Dale M, Edfors F, Fagerberg L, Rockberg J, Tegel H, Uhlén M, Qundos U, Schwenk JM.
Systematic Development of Sandwich Immunoassays for the Plasma Secretome.
Proteomics. 2019 19(15):e1900008.
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546 Fredolini C, Byström S, Sanchez-Rivera L, Ioannou M, Tamburro D, Pontén F, Branca RM, Nilsson P, Lehtiö J, Schwenk JM.
Systematic assessment of antibody selectivity in plasma based on a resource of enrichment profiles.
Sci Rep. 2019 9(1):8324.
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545 Edfors F, Forsström B, Vunk H, Kotol D, Fredolini C, Maddalo G, Svensson AS, Boström T, Tegel H, Nilsson P, Schwenk JM, Uhlen M.
Screening a Resource of Recombinant Protein Fragments for Targeted Proteomics.
J Proteome Res. 2019 18(7):2706-2718.
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544 Pernemalm M, Sandberg A, Zhu Y, Boekel J, Tamburro D, Schwenk JM, Björk A, Wahren-Herlenius M, Åmark H, Östenson CG, Westgren M, Lehtiö J.
In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta.
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543 Andersson A, Remnestål J, Nellgård B, Vunk H, Kotol D, Edfors F, Uhlén M, Schwenk JM, Ilag LL, Zetterberg H, Blennow K, Månberg A, Nilsson P, Fredolini C.
Development of parallel reaction monitoring assays for cerebrospinal fluid proteins associated with Alzheimer's disease.
Clin Chim Acta. 2019 494():79-93.
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542 Drobin K, Assadi G, Hong MG, Andersson E, Fredolini C, Forsström B, Reznichenko A, Akhter T, Ek WE, Bonfiglio F, Hansen MB, Sandberg K, Greco D, Repsilber D, Schwenk JM, D'Amato M, Halfvarson J.
Targeted Analysis of Serum Proteins Encoded at Known Inflammatory Bowel Disease Risk Loci.
Inflamm Bowel Dis. 2019 25(2):306-316.
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541 Zamani L, Lundqvist M, Zhang Y, Aberg M, Edfors F, Bidkhori G, Lindahl A, Mie A, Mardinoglu A, Field R, Turner R, Rockberg J, Chotteau V.
High Cell Density Perfusion Culture has a Maintained Exoproteome and Metabolome.
Biotechnol J. 2018 13(10):e1800036.
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540 Mardinoglu A, Gogg S, Lotta LA, Stančáková A, Nerstedt A, Boren J, Blüher M, Ferrannini E, Langenberg C, Wareham NJ, Laakso M, Smith U.
Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes.
EBioMedicine. 2018 27():151-155.
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539 Liu Z, Mardinoglu A, Que S.
Letter: dose-response analysis revealed closer relationship between obesity and perioperative outcomes in patients after liver transplantation.
Aliment Pharmacol Ther. 2018 47(2):310-312.
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538 Piening BD, Zhou W, Contrepois K, Röst H, Gu Urban GJ, Mishra T, Hanson BM, Bautista EJ, Leopold S, Yeh CY, Spakowicz D, Banerjee I, Chen C, Kukurba K, Perelman D, Craig C, Colbert E, Salins D, Rego S, Lee S, Zhang C, Wheeler J, Sailani MR, Liang L, Abbott C, Gerstein M, Mardinoglu A, Smith U, Rubin DL, Pitteri S, Sodergren E, McLaughlin TL, Weinstock GM, Snyder MP.
Integrative Personal Omics Profiles during Periods of Weight Gain and Loss.
Cell Syst. 2018 6(2):157-170.e8.
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537 Liu Z, Liang S, Que S, Zhou L, Zheng S, Mardinoglu A.
Meta-Analysis of Adiponectin as a Biomarker for the Detection of Metabolic Syndrome.
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536 Zhang C, Bidkhori G, Benfeitas R, Lee S, Arif M, Uhlén M, Mardinoglu A.
ESS: A Tool for Genome-Scale Quantification of Essentiality Score for Reaction/Genes in Constraint-Based Modeling.
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535 Zhang X, Mardinoglu A, Joosten LAB, Kuivenhoven JA, Li Y, Netea MG, Groen AK.
Identification of Discriminating Metabolic Pathways and Metabolites in Human PBMCs Stimulated by Various Pathogenic Agents.
Front Physiol. 2018 9():139.
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534 Turanli B, Karagoz K, Gulfidan G, Sinha R, Mardinoglu A, Arga KY.
A Network-Based Cancer Drug Discovery: From Integrated Multi-Omics Approaches to Precision Medicine.
Curr Pharm Des. 2018 24(32):3778-3790.
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533 Håversen L, Sundelin JP, Mardinoglu A, Rutberg M, Ståhlman M, Wilhelmsson U, Hultén LM, Pekny M, Fogelstrand P, Bentzon JF, Levin M, Borén J.
Vimentin deficiency in macrophages induces increased oxidative stress and vascular inflammation but attenuates atherosclerosis in mice.
Sci Rep. 2018 8(1):16973.
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532 Bidkhori G, Benfeitas R, Klevstig M, Zhang C, Nielsen J, Uhlen M, Boren J, Mardinoglu A.
Metabolic network-based stratification of hepatocellular carcinoma reveals three distinct tumor subtypes.
Proc Natl Acad Sci U S A. 2018 115(50):E11874-E11883.
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531 Nicholson AM, Olpe C, Hoyle A, Thorsen AS, Rus T, Colombé M, Brunton-Sim R, Kemp R, Marks K, Quirke P, Malhotra S, Ten Hoopen R, Ibrahim A, Lindskog C, Myers MB, Parsons B, Tavaré S, Wilkinson M, Morrissey E, Winton DJ.
Fixation and Spread of Somatic Mutations in Adult Human Colonic Epithelium.
Cell Stem Cell. 2018 22(6):909-918.e8.
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530 Morin E, Sjöberg E, Tjomsland V, Testini C, Lindskog C, Franklin O, Sund M, Öhlund D, Kiflemariam S, Sjöblom T, Claesson-Welsh L.
VEGF receptor-2/neuropilin 1 trans-complex formation between endothelial and tumor cells is an independent predictor of pancreatic cancer survival.
J Pathol. 2018 246(3):311-322.
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529 Miyashita N, Horie M, Suzuki HI, Yoshihara M, Djureinovic D, Persson J, Brunnström H, Lindskog C, Elfving H, Micke P, Saito A, Nagase T.
An Integrative Analysis of Transcriptome and Epigenome Features of ASCL1-Positive Lung Adenocarcinomas.
J Thorac Oncol. 2018 13(11):1676-1691.
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528 Strakova K, Kowalski-Jahn M, Gybel T, Valnohova J, Dhople VM, Harnos J, Bernatik O, Ganji RS, Zdrahal Z, Mulder J, Lindskog C, Bryja V, Schulte G.
Dishevelled enables casein kinase 1-mediated phosphorylation of Frizzled 6 required for cell membrane localization.
J Biol Chem. 2018 293(48):18477-18493.
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527 Guo J, Grow EJ, Mlcochova H, Maher GJ, Lindskog C, Nie X, Guo Y, Takei Y, Yun J, Cai L, Kim R, Carrell DT, Goriely A, Hotaling JM, Cairns BR.
The adult human testis transcriptional cell atlas.
Cell Res. 2018 28(12):1141-1157.
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526 Reuterswärd P, Bergström S, Orikiiriza J, Lindquist E, Bergström S, Andersson Svahn H, Ayoglu B, Uhlén M, Wahlgren M, Normark J, Ribacke U, Nilsson P.
Levels of human proteins in plasma associated with acute paediatric malaria.
Malar J. 2018 17(1):426.
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525 Quintana MDP, Ch'ng JH, Zandian A, Imam M, Hultenby K, Theisen M, Nilsson P, Qundos U, Moll K, Chan S, Wahlgren M.
SURGE complex of Plasmodium falciparum in the rhoptry-neck (SURFIN4.2-RON4-GLURP) contributes to merozoite invasion.
PLoS One. 2018 13(8):e0201669.
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524 Frostegård J, Hellström C, Nilsson P, Frostegård AG, Ajeganova S.
Autoantibody profiling reveals four protein candidate autoantigens associated with systemic lupus erythematosus.
Lupus. 2018 27(10):1670-1678.
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523 Sjöberg R, Andersson E, Hellström C, Mattsson C, Schwenk JM, Nilsson P, Ayoglu B.
High-Density Antigen Microarrays for the Assessment of Antibody Selectivity and Off-Target Binding.
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522 Ayoglu B, Nilsson P, Schwenk JM.
Multiplexed Antigen Bead Arrays for the Assessment of Antibody Selectivity and Epitope Mapping.
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521 Bremer HD, Landegren N, Sjöberg R, Hallgren Å, Renneker S, Lattwein E, Leonard D, Eloranta ML, Rönnblom L, Nordmark G, Nilsson P, Andersson G, Lilliehöök I, Lindblad-Toh K, Kämpe O, Hansson-Hamlin H.
ILF2 and ILF3 are autoantigens in canine systemic autoimmune disease.
Sci Rep. 2018 8(1):4852.
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520 Garranzo-Asensio M, San Segundo-Acosta P, Martínez-Useros J, Montero-Calle A, Fernández-Aceñero MJ, Häggmark-Månberg A, Pelaez-Garcia A, Villalba M, Rabano A, Nilsson P, Barderas R.
Identification of prefrontal cortex protein alterations in Alzheimer's disease.
Oncotarget. 2018 9(13):10847-10867.
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519 Quintana MDP, Ch'ng JH, Moll K, Zandian A, Nilsson P, Idris ZM, Saiwaew S, Qundos U, Wahlgren M.
Antibodies in children with malaria to PfEMP1, RIFIN and SURFIN expressed at the Plasmodium falciparum parasitized red blood cell surface.
Sci Rep. 2018 8(1):3262.
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518 Weidner LD, Kannan P, Mitsios N, Kang SJ, Hall MD, Theodore WH, Innis RB, Mulder J.
The expression of inflammatory markers and their potential influence on efflux transporters in drug-resistant mesial temporal lobe epilepsy tissue.
Epilepsia. 2018 59(8):1507-1517.
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517 Dos Remedios CG, Lal SP, Li A, McNamara J, Keogh A, Macdonald PS, Cooke R, Ehler E, Knöll R, Marston SB, Stelzer J, Granzier H, Bezzina C, van Dijk S, De Man F, Stienen GJM, Odeberg J, Pontén F, Linke WA, van der Velden J.
Correction to: The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease.
Biophys Rev. 2018 10(3):941.
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516 Casar-Borota O, Bollerslev J, Pontén F.
Immunohistochemistry for transcription factor T-Pit as a tool in diagnostics of corticotroph pituitary tumours.
Pituitary. 2018 21(4):443.
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515 Huvila J, Laajala TD, Edqvist PH, Mardinoglu A, Talve L, Pontén F, Grénman S, Carpén O, Aittokallio T, Auranen A.
Combined ASRGL1 and p53 immunohistochemistry as an independent predictor of survival in endometrioid endometrial carcinoma.
Gynecol Oncol. 2018 149(1):173-180.
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514 Omenn GS, Lane L, Overall CM, Corrales FJ, Schwenk JM, Paik YK, Van Eyk JE, Liu S, Snyder M, Baker MS, Deutsch EW.
Progress on Identifying and Characterizing the Human Proteome: 2018 Metrics from the HUPO Human Proteome Project.
J Proteome Res. 2018 17(12):4031-4041.
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513 Djureinovic D, Dodig-Crnković T, Hellström C, Holgersson G, Bergqvist M, Mattsson JSM, Pontén F, Ståhle E, Schwenk JM, Micke P.
Detection of autoantibodies against cancer-testis antigens in non-small cell lung cancer.
Lung Cancer. 2018 125():157-163.
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512 Mönnich M, Borgeskov L, Breslin L, Jakobsen L, Rogowski M, Doganli C, Schrøder JM, Mogensen JB, Blinkenkjær L, Harder LM, Lundberg E, Geimer S, Christensen ST, Andersen JS, Larsen LA, Pedersen LB.
CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium.
Cell Rep. 2018 22(10):2584-2592.
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511 Guala D, Bernhem K, Blal HA, Jans D, Lundberg E, Brismar H, Sonnhammer ELL.
Experimental validation of predicted cancer genes using FRET.
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510 Edfors F, Hober A, Linderbäck K, Maddalo G, Azimi A, Sivertsson Å, Tegel H, Hober S, Szigyarto CA, Fagerberg L, von Feilitzen K, Oksvold P, Lindskog C, Forsström B, Uhlen M.
Enhanced validation of antibodies for research applications.
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509 Lovric A, Granér M, Bjornson E, Arif M, Benfeitas R, Nyman K, Ståhlman M, Pentikäinen MO, Lundbom J, Hakkarainen A, Sirén R, Nieminen MS, Lundbom N, Lauerma K, Taskinen MR, Mardinoglu A, Boren J.
Characterization of different fat depots in NAFLD using inflammation-associated proteome, lipidome and metabolome.
Sci Rep. 2018 8(1):14200.
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508 Sjöstedt E, Sivertsson Å, Hikmet Noraddin F, Katona B, Näsström Å, Vuu J, Kesti D, Oksvold P, Edqvist PH, Olsson I, Uhlén M, Lindskog C.
Integration of Transcriptomics and Antibody-Based Proteomics for Exploration of Proteins Expressed in Specialized Tissues.
J Proteome Res. 2018 17(12):4127-4137.
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TCSBN: a database of tissue and cancer specific biological networks.
Nucleic Acids Res. 2018 46(D1):D595-D600.
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506 Mardinoglu A, Uhlen M, Borén J.
Broad Views of Non-alcoholic Fatty Liver Disease.
Cell Syst. 2018 6(1):7-9.
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An Integrated Understanding of the Rapid Metabolic Benefits of a Carbohydrate-Restricted Diet on Hepatic Steatosis in Humans.
Cell Metab. 2018 27(3):559-571.e5.
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504 Karnevi E, Dror LB, Mardinoglu A, Elebro J, Heby M, Olofsson SE, Nodin B, Eberhard J, Gallagher W, Uhlén M, Jirström K.
Translational study reveals a two-faced role of RBM3 in pancreatic cancer and suggests its potential value as a biomarker for improved patient stratification.
Oncotarget. 2018 9(5):6188-6200.
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503 Azimi A, Caramuta S, Seashore-Ludlow B, Boström J, Robinson JL, Edfors F, Tuominen R, Kemper K, Krijgsman O, Peeper DS, Nielsen J, Hansson J, Egyhazi Brage S, Altun M, Uhlen M, Maddalo G.
Targeting CDK2 overcomes melanoma resistance against BRAF and Hsp90 inhibitors.
Mol Syst Biol. 2018 14(3):e7858.
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Mining the Human Tissue Proteome for Protein Citrullination.
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501 Mardinoglu A, Boren J, Smith U, Uhlen M, Nielsen J.
Systems biology in hepatology: approaches and applications.
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500 Turanli B, Grøtli M, Boren J, Nielsen J, Uhlen M, Arga KY, Mardinoglu A.
Drug Repositioning for Effective Prostate Cancer Treatment.
Front Physiol. 2018 9():500.
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499 Zhang MD, Su J, Adori C, Cinquina V, Malenczyk K, Girach F, Peng C, Ernfors P, Löw P, Borgius L, Kiehn O, Watanabe M, Uhlén M, Mitsios N, Mulder J, Harkany T, Hökfelt T.
Ca2+-binding protein NECAB2 facilitates inflammatory pain hypersensitivity.
J Clin Invest. 2018 128(9):3757-3768.
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Understanding the Representative Gut Microbiota Dysbiosis in Metformin-Treated Type 2 Diabetes Patients Using Genome-Scale Metabolic Modeling.
Front Physiol. 2018 9():775.
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Metabolic Network-Based Identification and Prioritization of Anticancer Targets Based on Expression Data in Hepatocellular Carcinoma.
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496 Matic LP, Jesus Iglesias M, Vesterlund M, Lengquist M, Hong MG, Saieed S, Sanchez-Rivera L, Berg M, Razuvaev A, Kronqvist M, Lund K, Caidahl K, Gillgren P, Pontén F, Uhlén M, Schwenk JM, Hansson GK, Paulsson-Berne G, Fagman E, Roy J, Hultgren R, Bergström G, Lehtiö J, Odeberg J, Hedin U.
Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage.
JACC Basic Transl Sci. 2018 3(4):464-480.
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495 Dusart P, Fagerberg L, Perisic L, Civelek M, Struck E, Hedin U, Uhlén M, Trégouët DA, Renné T, Odeberg J, Butler LM.
A systems-approach reveals human nestin is an endothelial-enriched, angiogenesis-independent intermediate filament protein.
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494 O'Hagan S, Wright Muelas M, Day PJ, Lundberg E, Kell DB.
GeneGini: Assessment via the Gini Coefficient of Reference "Housekeeping" Genes and Diverse Human Transporter Expression Profiles.
Cell Syst. 2018 6(2):230-244.e1.
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493 Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B.
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Nat Chem Biol. 2018 14(3):206-214.
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492 Sullivan DP, Winsnes CF, Åkesson L, Hjelmare M, Wiking M, Schutten R, Campbell L, Leifsson H, Rhodes S, Nordgren A, Smith K, Revaz B, Finnbogason B, Szantner A, Lundberg E.
Deep learning is combined with massive-scale citizen science to improve large-scale image classification.
Nat Biotechnol. 2018 36(9):820-828.
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491 Danielsson F, Fasterius E, Sullivan D, Hases L, Sanli K, Zhang C, Mardinoglu A, Al-Khalili C, Huss M, Uhlén M, Williams C, Lundberg E.
Transcriptome profiling of the interconnection of pathways involved in malignant transformation and response to hypoxia.
Oncotarget. 2018 9(28):19730-19744.
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490 Sullivan DP, Lundberg E.
Seeing More: A Future of Augmented Microscopy.
Cell. 2018 173(3):546-548.
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489 Sen P, Mardinogulu A, Nielsen J.
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488 Romanov RA, Zeisel A, Bakker J, Girach F, Hellysaz A, Tomer R, Alpár A, Mulder J, Clotman F, Keimpema E, Hsueh B, Crow AK, Martens H, Schwindling C, Calvigioni D, Bains JS, Máté Z, Szabó G, Yanagawa Y, Zhang MD, Rendeiro A, Farlik M, Uhlén M, Wulff P, Bock C, Broberger C, Deisseroth K, Hökfelt T, Linnarsson S, Horvath TL, Harkany T.
Molecular interrogation of hypothalamic organization reveals distinct dopamine neuronal subtypes.
Nat Neurosci. 2017 20(2):176-188.
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487 Malenczyk K, Girach F, Szodorai E, Storm P, Segerstolpe Å, Tortoriello G, Schnell R, Mulder J, Romanov RA, Borók E, Piscitelli F, Di Marzo V, Szabó G, Sandberg R, Kubicek S, Lubec G, Hökfelt T, Wagner L, Groop L, Harkany T.
A TRPV1-to-secretagogin regulatory axis controls pancreatic β-cell survival by modulating protein turnover.
EMBO J. 2017 36(14):2107-2125.
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486 Niinivirta M, Enblad G, Edqvist PH, Pontén F, Dragomir A, Ullenhag GJ.
Tumoral ANXA1 Is a Predictive Marker for Sunitinib Treatment of Renal Cancer Patients.
J Cancer. 2017 8(19):3975-3983.
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485 Carreras-Puigvert J, Zitnik M, Jemth AS, Carter M, Unterlass JE, Hallström B, Loseva O, Karem Z, Calderón-Montaño JM, Lindskog C, Edqvist PH, Matuszewski DJ, Ait Blal H, Berntsson RPA, Häggblad M, Martens U, Studham M, Lundgren B, Wählby C, Sonnhammer ELL, Lundberg E, Stenmark P, Zupan B, Helleday T.
A comprehensive structural, biochemical and biological profiling of the human NUDIX hydrolase family.
Nat Commun. 2017 8(1):1541.
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484 Boström J, Sramkova Z, Salašová A, Johard H, Mahdessian D, Fedr R, Marks C, Medalová J, Souček K, Lundberg E, Linnarsson S, Bryja V, Sekyrova P, Altun M, Andäng M.
Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells.
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483 Feizi A, Gatto F, Uhlen M, Nielsen J.
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481 Birse KD, Romas LM, Guthrie BL, Nilsson P, Bosire R, Kiarie J, Farquhar C, Broliden K, Burgener AD.
Genital Injury Signatures and Microbiome Alterations Associated With Depot Medroxyprogesterone Acetate Usage and Intravaginal Drying Practices.
J Infect Dis. 2017 215(4):590-598.
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480 Svedberg G, Jeong Y, Na H, Jang J, Nilsson P, Kwon S, Gantelius J, Svahn HA.
Towards encoded particles for highly multiplexed colorimetric point of care autoantibody detection.
Lab Chip. 2017 17(3):549-556.
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479 Checa A, Idborg H, Zandian A, Sar DG, Surowiec I, Trygg J, Svenungsson E, Jakobsson PJ, Nilsson P, Gunnarsson I, Wheelock CE.
Dysregulations in circulating sphingolipids associate with disease activity indices in female patients with systemic lupus erythematosus: a cross-sectional study.
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478 Ch'ng JH, Sirel M, Zandian A, Del Pilar Quintana M, Chun Leung Chan S, Moll K, Tellgren-Roth A, Nilsson I, Nilsson P, Qundos U, Wahlgren M.
Epitopes of anti-RIFIN antibodies and characterization of rif-expressing Plasmodium falciparum parasites by RNA sequencing.
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477 Sierra-Sánchez Á, Garrido-Martín D, Lourido L, González-González M, Díez P, Ruiz-Romero C, Sjöber R, Droste C, De Las Rivas J, Nilsson P, Blanco F, Fuentes M.
Screening and Validation of Novel Biomarkers in Osteoarticular Pathologies by Comprehensive Combination of Protein Array Technologies.
J Proteome Res. 2017 16(5):1890-1899.
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476 Ge C, Tong D, Liang B, Lönnblom E, Schneider N, Hagert C, Viljanen J, Ayoglu B, Stawikowska R, Nilsson P, Fields GB, Skogh T, Kastbom A, Kihlberg J, Burkhardt H, Dobritzsch D, Holmdahl R.
Anti-citrullinated protein antibodies cause arthritis by cross-reactivity to joint cartilage.
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475 Skogs M, Stadler C, Schutten R, Hjelmare M, Gnann C, Björk L, Poser I, Hyman A, Uhlén M, Lundberg E.
Antibody Validation in Bioimaging Applications Based on Endogenous Expression of Tagged Proteins.
J Proteome Res. 2017 16(1):147-155.
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474 Alkasalias T, Alexeyenko A, Hennig K, Danielsson F, Lebbink RJ, Fielden M, Turunen SP, Lehti K, Kashuba V, Madapura HS, Bozoky B, Lundberg E, Balland M, Guvén H, Klein G, Gad AK, Pavlova T.
RhoA knockout fibroblasts lose tumor-inhibitory capacity in vitro and promote tumor growth in vivo.
Proc Natl Acad Sci U S A. 2017 114(8):E1413-E1421.
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473 Omenn GS, Lane L, Lundberg EK, Overall CM, Deutsch EW.
Progress on the HUPO Draft Human Proteome: 2017 Metrics of the Human Proteome Project.
J Proteome Res. 2017 Epub ahead of print
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472 Ly T, Whigham A, Clarke R, Brenes-Murillo AJ, Estes B, Madhessian D, Lundberg E, Wadsworth P, Lamond AI.
Proteomic analysis of cell cycle progression in asynchronous cultures, including mitotic subphases, using PRIMMUS.
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471 Brunnström H, Johansson A, Westbom-Fremer S, Backman M, Djureinovic D, Patthey A, Isaksson-Mettävainio M, Gulyas M, Micke P.
PD-L1 immunohistochemistry in clinical diagnostics of lung cancer: inter-pathologist variability is higher than assay variability.
Mod Pathol. 2017 30(10):1411-1421.
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470 Jedlinski A, Garvin S, Johansson AC, Edqvist PH, Ponten F, Roberg K.
Cetuximab sensitivity of head and neck squamous cell carcinoma xenografts is associated with treatment-induced reduction in EGFR, pEGFR, and pSrc.
J Oral Pathol Med. 2017 46(9):717-724.
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469 Gremel G, Djureinovic D, Niinivirta M, Laird A, Ljungqvist O, Johannesson H, Bergman J, Edqvist PH, Navani S, Khan N, Patil T, Sivertsson Å, Uhlén M, Harrison DJ, Ullenhag GJ, Stewart GD, Pontén F.
A systematic search strategy identifies cubilin as independent prognostic marker for renal cell carcinoma.
BMC Cancer. 2017 17(1):9.
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468 Niinivirta M, Enblad G, Edqvist PH, Pontén F, Dragomir A, Ullenhag GJ.
Tumoral cubilin is a predictive marker for treatment of renal cancer patients with sunitinib and sorafenib.
J Cancer Res Clin Oncol. 2017 143(6):961-970.
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467 Grinberg M, Djureinovic D, Brunnström HR, Mattsson JS, Edlund K, Hengstler JG, La Fleur L, Ekman S, Koyi H, Branden E, Ståhle E, Jirström K, Tracy DK, Pontén F, Botling J, Rahnenführer J, Micke P.
Reaching the limits of prognostication in non-small cell lung cancer: an optimized biomarker panel fails to outperform clinical parameters.
Mod Pathol. 2017 30(7):964-977.
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466 Bondeson ML, Ericson K, Gudmundsson S, Ameur A, Pontén F, Wesström J, Frykholm C, Wilbe M.
A nonsense mutation in CEP55 defines a new locus for a Meckel-like syndrome, an autosomal recessive lethal fetal ciliopathy.
Clin Genet. 2017 92(5):510-516.
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465 Roy A, Attarha S, Weishaupt H, Edqvist PH, Swartling FJ, Bergqvist M, Siebzehnrubl FA, Smits A, Pontén F, Tchougounova E.
Serglycin as a potential biomarker for glioma: association of serglycin expression, extent of mast cell recruitment and glioblastoma progression.
Oncotarget. 2017 8(15):24815-24827.
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464 Roy A, Libard S, Weishaupt H, Gustavsson I, Uhrbom L, Hesselager G, Swartling FJ, Pontén F, Alafuzoff I, Tchougounova E.
Mast Cell Infiltration in Human Brain Metastases Modulates the Microenvironment and Contributes to the Metastatic Potential.
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463 Casar-Borota O, Botling J, Granberg D, Stigare J, Wikström J, Boldt HB, Kristensen BW, Pontén F, Trouillas J.
Serotonin, ATRX, and DAXX Expression in Pituitary Adenomas: Markers in the Differential Diagnosis of Neuroendocrine Tumors of the Sellar Region.
Am J Surg Pathol. 2017 41(9):1238-1246.
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462 Siesing C, Sorbye H, Dragomir A, Pfeiffer P, Qvortrup C, Pontén F, Jirström K, Glimelius B, Eberhard J.
High RBM3 expression is associated with an improved survival and oxaliplatin response in patients with metastatic colorectal cancer.
PLoS One. 2017 12(8):e0182512.
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461 Dos Remedios CG, Lal SP, Li A, McNamara J, Keogh A, Macdonald PS, Cooke R, Ehler E, Knöll R, Marston SB, Stelzer J, Granzier H, Bezzina C, van Dijk S, De Man F, Stienen GJM, Odeberg J, Pontén F, Linke , Linke W, van der Velden J.
The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease.
Biophys Rev. 2017 9(4):431-441.
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460 Fredholm H, Magnusson K, Lindström LS, Tobin NP, Lindman H, Bergh J, Holmberg L, Pontén F, Frisell J, Fredriksson I.
Breast cancer in young women and prognosis: How important are proliferation markers?
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459 Zieba A, Ponten F, Uhlén M, Landegren U.
In situ protein detection with enhanced specificity using DNA-conjugated antibodies and proximity ligation.
Mod Pathol. 2017 Epub ahead of print
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458 Sjöstedt E, Bollerslev J, Mulder J, Lindskog C, Pontén F, Casar-Borota O.
A specific antibody to detect transcription factor T-Pit: a reliable marker of corticotroph cell differentiation and a tool to improve the classification of pituitary neuroendocrine tumours.
Acta Neuropathol. 2017 Epub ahead of print
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457 Carapito C, Duek P, Macron C, Seffals M, Rondel K, Delalande F, Lindskog C, Fréour T, Vandenbrouck Y, Lane L, Pineau C.
Validating Missing Proteins in Human Sperm Cells by Targeted Mass-Spectrometry- and Antibody-based Methods.
J Proteome Res. 2017 Epub ahead of print
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456 Thul PJ, Lindskog C.
The human protein atlas: A spatial map of the human proteome.
Protein Sci. 2017 Epub ahead of print
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455 Guo J, Grow EJ, Yi C, Mlcochova H, Maher GJ, Lindskog C, Murphy PJ, Wike CL, Carrell DT, Goriely A, Hotaling JM, Cairns BR.
Chromatin and Single-Cell RNA-Seq Profiling Reveal Dynamic Signaling and Metabolic Transitions during Human Spermatogonial Stem Cell Development.
Cell Stem Cell. 2017 21(4):533-546.e6.
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454 Bosley J, Boren C, Lee S, Grøtli M, Nielsen J, Uhlen M, Boren J, Mardinoglu A.
Improving the economics of NASH/NAFLD treatment through the use of systems biology.
Drug Discov Today. 2017 22(10):1532-1538.
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453 Liu Z, Que S, Mardinoglu A.
Rediscussion on linearity between fibrosis stages and mortality risk in nonalcoholic fatty liver disease patients.
Hepatology. 2017 66(4):1357-1358.
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452 Liu Z, Que S, Zhou L, Zheng S, Romeo S, Mardinoglu A, Valenti L.
The effect of the TM6SF2 E167K variant on liver steatosis and fibrosis in patients with chronic hepatitis C: a meta-analysis.
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451 Lee S, Zhang C, Liu Z, Klevstig M, Mukhopadhyay B, Bergentall M, Cinar R, Ståhlman M, Sikanic N, Park JK, Deshmukh S, Harzandi AM, Kuijpers T, Grøtli M, Elsässer SJ, Piening BD, Snyder M, Smith U, Nielsen J, Bäckhed F, Kunos G, Uhlen M, Boren J, Mardinoglu A.
Network analyses identify liver-specific targets for treating liver diseases.
Mol Syst Biol. 2017 13(8):938.
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450 Mardinoglu A, Stančáková A, Lotta LA, Kuusisto J, Boren J, Blüher M, Wareham NJ, Ferrannini E, Groop PH, Laakso M, Langenberg C, Smith U.
Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease.
Cell Metab. 2017 26(2):281-283.
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449 Benfeitas R, Uhlen M, Nielsen J, Mardinoglu A.
New Challenges to Study Heterogeneity in Cancer Redox Metabolism.
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448 Mardinoglu A, Borén J.
AUP1 (Ancient Ubiquitous Protein 1): A Molecular Link Between Hepatic Lipid Mobilization and VLDL Secretion.
Arterioscler Thromb Vasc Biol. 2017 37(4):609-610.
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447 Mardinoglu A, Bjornson E, Zhang C, Klevstig M, Söderlund S, Ståhlman M, Adiels M, Hakkarainen A, Lundbom N, Kilicarslan M, Hallström BM, Lundbom J, Vergès B, Barrett PH, Watts GF, Serlie MJ, Nielsen J, Uhlén M, Smith U, Marschall HU, Taskinen MR, Boren J.
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Mol Syst Biol. 2017 13(3):916.
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Predicting growth of the healthy infant using a genome scale metabolic model.
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445 Schwenk JM, Omenn GS, Sun Z, Campbell DS, Baker MS, Overall CM, Aebersold R, Moritz RL, Deutsch EW.
The Human Plasma Proteome Draft of 2017: Building on the Human Plasma PeptideAtlas from Mass Spectrometry and Complementary Assays.
J Proteome Res. 2017 Epub ahead of print
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444 Zandian A, Wingård L, Nilsson H, Sjöstedt E, Johansson DX, Just D, Hellström C, Uhlén M, Schwenk JM, Häggmark-Månberg A, Norbeck O, Owe-Larsson B, Nilsson P, Persson MAA.
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Transl Psychiatry. 2017 7(7):e1177.
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443 Glimelius B, Melin B, Enblad G, Alafuzoff I, Beskow A, Ahlström H, Bill-Axelson A, Birgisson H, Björ O, Edqvist PH, Hansson T, Helleday T, Hellman P, Henriksson K, Hesselager G, Hultdin M, Häggman M, Höglund M, Jonsson H, Larsson C, Lindman H, Ljuslinder I, Mindus S, Nygren P, Pontén F, Riklund K, Rosenquist R, Sandin F, Schwenk JM, Stenling R, Stålberg K, Stålberg P, Sundström C, Thellenberg Karlsson C, Westermark B, Bergh A, Claesson-Welsh L, Palmqvist R, Sjöblom T.
U-CAN: a prospective longitudinal collection of biomaterials and clinical information from adult cancer patients in Sweden.
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442 Byström S, Fredolini C, Edqvist PH, Nyaiesh EN, Drobin K, Uhlén M, Bergqvist M, Pontén F, Schwenk JM.
Affinity Proteomics Exploration of Melanoma Identifies Proteins in Serum with Associations to T-Stage and Recurrence.
Transl Oncol. 2017 10(3):385-395.
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A Preliminary Report: Radical Surgery and Stem Cell Transplantation for the Treatment of Patients With Pancreatic Cancer.
J Immunother. 2017 Epub ahead of print
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440 Lourido L, Ayoglu B, Fernández-Tajes J, Oreiro N, Henjes F, Hellström C, Schwenk JM, Ruiz-Romero C, Nilsson P, Blanco FJ.
Discovery of circulating proteins associated to knee radiographic osteoarthritis.
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439 Zandian A, Forsström B, Häggmark-Månberg A, Schwenk JM, Uhlén M, Nilsson P, Ayoglu B.
Whole-Proteome Peptide Microarrays for Profiling Autoantibody Repertoires within Multiple Sclerosis and Narcolepsy.
J Proteome Res. 2017 16(3):1300-1314.
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438 Hellström C, Dodig-Crnković T, Hong MG, Schwenk JM, Nilsson P, Sjöberg R.
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437 Birgersson E, Schwenk JM, Ayoglu B.
Bead-Based and Multiplexed Immunoassays for Protein Profiling via Sequential Affinity Capture.
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436 Häggmark-Månberg A, Nilsson P, Schwenk JM.
Neuroproteomic Profiling of Cerebrospinal Fluid (CSF) by Multiplexed Affinity Arrays.
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435 Uhlen M, Zhang C, Lee S, Sjöstedt E, Fagerberg L, Bidkhori G, Benfeitas R, Arif M, Liu Z, Edfors F, Sanli K, von Feilitzen K, Oksvold P, Lundberg E, Hober S, Nilsson P, Mattsson J, Schwenk JM, Brunnström H, Glimelius B, Sjöblom T, Edqvist PH, Djureinovic D, Micke P, Lindskog C, Mardinoglu A, Ponten F.
A pathology atlas of the human cancer transcriptome.
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434 Thul PJ, Åkesson L, Wiking M, Mahdessian D, Geladaki A, Ait Blal H, Alm T, Asplund A, Björk L, Breckels LM, Bäckström A, Danielsson F, Fagerberg L, Fall J, Gatto L, Gnann C, Hober S, Hjelmare M, Johansson F, Lee S, Lindskog C, Mulder J, Mulvey CM, Nilsson P, Oksvold P, Rockberg J, Schutten R, Schwenk JM, Sivertsson Å, Sjöstedt E, Skogs M, Stadler C, Sullivan DP, Tegel H, Winsnes C, Zhang C, Zwahlen M, Mardinoglu A, Pontén F, von Feilitzen K, Lilley KS, Uhlén M, Lundberg E.
A subcellular map of the human proteome.
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The endosomal transcriptional regulator RNF11 integrates degradation and transport of EGFR.
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431 Micke P, Mattsson JS, Djureinovic D, Nodin B, Jirström K, Tran L, Jönsson P, Planck M, Botling J, Brunnström H.
The Impact of the Fourth Edition of the WHO Classification of Lung Tumours on Histological Classification of Resected Pulmonary NSCCs.
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430 Edfors F, Danielsson F, Hallström BM, Käll L, Lundberg E, Pontén F, Forsström B, Uhlén M.
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429 van Kempen LC, Redpath M, Elchebly M, Klein KO, Papadakis AI, Wilmott JS, Scolyer RA, Edqvist PH, Pontén F, Schadendorf D, van Rijk AF, Michiels S, Dumay A, Helbling-Leclerc A, Dessen P, Wouters J, Stass M, Greenwood CM, Ghanem GE, van den Oord J, Feunteun J, Spatz A.
The protein phosphatase 2A regulatory subunit PR70 is a gonosomal melanoma tumor suppressor gene.
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428 Ten Berge JC, van Rosmalen J, Vermeer J, Hellström C, Lindskog C, Nilsson P, Qundos U, Rothova A, Schreurs MW.
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427 Mardinoglu A, Nielsen J.
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425 Magnusson K, Gremel G, Rydén L, Pontén V, Uhlén M, Dimberg A, Jirström K, Pontén F.
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BMC Cancer. 2016 16(1):904.
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424 Bergman J, Botling J, Fagerberg L, Hallström BM, Djureinovic D, Uhlén M, Pontén F.
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423 Kannan P, Schain M, Kretzschmar WW, Weidner L, Mitsios N, Gulyás B, Blom H, Gottesman MM, Innis RB, Hall MD, Mulder J.
An automated method measures variability in P-glycoprotein and ABCG2 densities across brain regions and brain matter.
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422 Musunuri S, Khoonsari PE, Mikus M, Wetterhall M, Häggmark-Mänberg A, Lannfelt L, Erlandsson A, Bergquist J, Ingelsson M, Shevchenko G, Nilsson P, Kultima K.
Increased Levels of Extracellular Microvesicle Markers and Decreased Levels of Endocytic/Exocytic Proteins in the Alzheimer's Disease Brain.
J Alzheimers Dis. 2016 54(4):1671-1686.
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421 Thelin EP, Just D, Frostell A, Häggmark-Månberg A, Risling M, Svensson M, Nilsson P, Bellander BM.
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419 Schrötter A, Park YM, Marcus K, Martins-de-Souza D, Nilsson P, Magraoui FE, Meyer HE, Grinberg LT.
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418 Khoonsari PE, Häggmark A, Lönnberg M, Mikus M, Kilander L, Lannfelt L, Bergquist J, Ingelsson M, Nilsson P, Kultima K, Shevchenko G.
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417 Mardinoglu A, Boren J, Smith U.
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416 Björnson E, Borén J, Mardinoglu A.
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415 Elsemman IE, Mardinoglu A, Shoaie S, Soliman TH, Nielsen J.
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412 Chaudhari A, Håversen L, Mobini R, Andersson L, Ståhlman M, Lu E, Rutberg M, Fogelstrand P, Ekroos K, Mardinoglu A, Levin M, Perkins R, Borén J.
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PROX1 is a novel pathway-specific prognostic biomarker for high-grade astrocytomas; results from independent glioblastoma cohorts stratified by age and IDH mutation status.
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The prognostic value and therapeutic target role of stathmin-1 in urinary bladder cancer.
Br J Cancer. 2014 111(6):1180-7.
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289 O Leary PC, Terrile M, Bajor M, Gaj P, Hennessy BT, Mills GB, Zagozdzon A, O Connor DP, Brennan DJ, Connor K, Li J, Gonzalez-Angulo AM, Sun HD, Pu JX, Pontén F, Uhlén M, Jirström K, Nowis DA, Crown JP, Zagozdzon R, Gallagher WM.
Peroxiredoxin-1 protects estrogen receptor alpha from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer.
Breast Cancer Res. 2014 16(4):R79.
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288 Ayoglu B, Chaouch A, Lochmüller H, Politano L, Bertini E, Spitali P, Hiller M, Niks EH, Gualandi F, Pontén F, Bushby K, Aartsma-Rus A, Schwartz E, Le Priol Y, Straub V, Uhlén M, Cirak S, 't Hoen PA, Muntoni F, Ferlini A, Schwenk JM, Nilsson P, Al-Khalili Szigyarto C.
Affinity proteomics within rare diseases: a BIO-NMD study for blood biomarkers of muscular dystrophies.
EMBO Mol Med. 2014 6(7):918-36.
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287 Lindskog C, Kuhlwilm M, Davierwala A, Fu N, Hegde G, Uhlén M, Navani S, Pääbo S, Pontén F.
Analysis of candidate genes for lineage-specific expression changes in humans and primates.
J Proteome Res. 2014 13(8):3596-606.
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286 Gremel G, Wanders A, Cedernaes J, Fagerberg L, Hallström B, Edlund K, Sjöstedt E, Uhlén M, Pontén F.
The human gastrointestinal tract-specific transcriptome and proteome as defined by RNA sequencing and antibody-based profiling.
J Gastroenterol. 2014 Epub ahead of print
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285 O'Hurley G, Sjöstedt E, Rahman A, Li B, Kampf C, Pontén F, Gallagher WM, Lindskog C.
Garbage in, garbage out: a critical evaluation of strategies used for validation of immunohistochemical biomarkers.
Mol Oncol. 2014 8(4):783-98.
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284 Dragomir A, de Wit M, Johansson C, Uhlen M, Pontén F.
The role of SATB2 as a diagnostic marker for tumors of colorectal origin: Results of a pathology-based clinical prospective study.
Am J Clin Pathol. 2014 141(5):630-8.
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283 Micke P, Mattsson JS, Edlund K, Lohr M, Jirström K, Berglund A, Botling J, Rahnenfuehrer J, Marincevic M, Pontén F, Ekman S, Hengstler J, Wöll S, Sahin U, Türeci O.
Aberrantly activated claudin 6 and 18.2 as potential therapy targets in non-small-cell lung cancer.
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282 Kampf C, Mardinoglu A, Fagerberg L, Hallström BM, Edlund K, Lundberg E, Pontén F, Nielsen J, Uhlen M.
The human liver-specific proteome defined by transcriptomics and antibody-based profiling.
FASEB J. 2014 28(7):2901-14.
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281 Agren R, Mardinoglu A, Asplund A, Kampf C, Uhlen M, Nielsen J.
Identification of anticancer drugs for hepatocellular carcinoma through personalized genome-scale metabolic modeling.
Mol Syst Biol. 2014 10():721.
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280 Liem DA, Nsair A, Setty SP, Cadeiras M, Wang D, Maclellan R, Lotz C, Lin AJ, Tabaraki J, Li H, Ge J, Odeberg J, Ponten F, Larson E, Mulder J, Lundberg E, Weiss JN, Uhlen M, Ping P, Deng MC.
Molecular- and organelle-based predictive paradigm underlying recovery by left ventricular assist device support.
Circ Heart Fail. 2014 7(2):359-66.
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279 Bozoky B, Savchenko A, Guven H, Ponten F, Klein G, Szekely L.
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Cancer Med. 2014 3(3):485-91.
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278 Djureinovic D, Fagerberg L, Hallström B, Danielsson A, Lindskog C, Uhlén M, Pontén F.
The human testis-specific proteome defined by transcriptomics and antibody-based profiling.
Mol Hum Reprod. 2014 20(6):476-88.
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277 Howat WJ, Lewis A, Jones P, Kampf C, Pontén F, van der Loos CM, Gray N, Womack C, Warford A.
Antibody validation of immunohistochemistry for biomarker discovery: Recommendations of a consortium of academic and pharmaceutical based histopathology researchers.
Methods. 2014 Epub ahead of print
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276 Sooman L, Ekman S, Tsakonas G, Jaiswal A, Navani S, Edqvist PH, Pontén F, Bergström S, Johansson M, Wu X, Blomquist E, Bergqvist M, Gullbo J, Lennartsson J.
PTPN6 expression is epigenetically regulated and influences survival and response to chemotherapy in high-grade gliomas.
Tumour Biol. 2014 35(5):4479-88.
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275 Nilsson R, Jain M, Madhusudhan N, Sheppard NG, Strittmatter L, Kampf C, Huang J, Asplund A, Mootha VK.
Metabolic enzyme expression highlights a key role for MTHFD2 and the mitochondrial folate pathway in cancer.
Nat Commun. 2014 5():3128.
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274 Hansson J, Hultenby K, Cramnert C, Pontén F, Jansson H, Lindgren D, Axelson H, Johansson ME.
Evidence for a morphologically distinct and functionally robust cell type in the proximal tubules of human kidney.
Hum Pathol. 2014 45(2):382-93.
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273 Mardinoglu A, Agren R, Kampf C, Asplund A, Uhlen M, Nielsen J.
Genome-scale metabolic modelling of hepatocytes reveals serine deficiency in patients with non-alcoholic fatty liver disease.
Nat Commun. 2014 5():3083.
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272 de Wit M, Kant H, Piersma SR, Pham TV, Mongera S, van Berkel MP, Boven E, Pontén F, Meijer GA, Jimenez CR, Fijneman RJ.
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271 Hansson SF, Korsgren S, Pontén F, Korsgren O.
Detection of enterovirus in the islet cells of patients with type 1 diabetes: what do we learn from immunohistochemistry?
Diabetologia. 2014 57(3):645-6.
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270 Gremel G, Bergman J, Djureinovic D, Edqvist PH, Maindad V, Bharambe BM, Khan WA, Navani S, Elebro J, Jirström K, Hellberg D, Uhlén M, Micke P, Pontén F.
A systematic analysis of commonly used antibodies in cancer diagnostics.
Histopathology. 2014 64(2):293-305.
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269 Fagerberg L, Hallström BM, Oksvold P, Kampf C, Djureinovic D, Odeberg J, Habuka M, Tahmasebpoor S, Danielsson A, Edlund K, Asplund A, Sjöstedt E, Lundberg E, Szigyarto CA, Skogs M, Takanen JO, Berling H, Tegel H, Mulder J, Nilsson P, Schwenk JM, Lindskog C, Danielsson F, Mardinoglu A, Sivertsson A, von Feilitzen K, Forsberg M, Zwahlen M, Olsson I, Navani S, Huss M, Nielsen J, Ponten F, Uhlén M.
Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics.
Mol Cell Proteomics. 2014 13(2):397-406.
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268 Sherwood V, Chaurasiya SK, Ekström EJ, Guilmain W, Liu Q, Koeck T, Brown K, Hansson K, Agnarsdóttir M, Bergqvist M, Jirström K, Ponten F, James P, Andersson T.
WNT5A-mediated β-catenin-independent signalling is a novel regulator of cancer cell metabolism.
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267 Fei C, Atterby C, Edqvist PH, Pontén F, Zhang WW, Larsson E, Ryan FP.
Detection of the human endogenous retrovirus ERV3-encoded Env-protein in human tissues using antibody-based proteomics.
J R Soc Med. 2014 107(1):22-9.
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266 Popova SN, Bergqvist M, Dimberg A, Edqvist PH, Ekman S, Hesselager G, Ponten F, Smits A, Sooman L, Alafuzoff I.
Subtyping of gliomas of various WHO grades by the application of immunohistochemistry.
Histopathology. 2014 64(3):365-79.
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265 Edfors F, Boström T, Forsström B, Zeiler M, Johansson H, Lundberg E, Hober S, Lehtiö J, Mann M, Uhlen M.
Immunoproteomics using polyclonal antibodies and stable isotope-labeled affinity-purified recombinant proteins.
Mol Cell Proteomics. 2014 13(6):1611-24.
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264 Boström T, Johansson HJ, Lehtiö J, Uhlén M, Hober S.
Investigating the Applicability of Antibodies Generated within the Human Protein Atlas as Capture Agents in Immunoenrichment Coupled to Mass Spectrometry.
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263 Algenäs C, Agaton C, Fagerberg L, Asplund A, Björling L, Björling E, Kampf C, Lundberg E, Nilsson P, Persson A, Wester K, Pontén F, Wernérus H, Uhlén M, Ottosson Takanen J, Hober S.
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262 Forsström B, Bisławska Axnas B, Stengele KP, Bühler J, Albert TJ, Richmond TA, Jingxin Hu F, Nilsson P, Hudson EP, Rockberg J, Uhlen M.
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261 Bachmann J, Burté F, Pramana S, Conte I, Brown BJ, Orimadegun AE, Ajetunmobi WA, Afolabi NK, Akinkunmi F, Omokhodion S, Akinbami FO, Shokunbi WA, Kampf C, Pawitan Y, Uhlén M, Sodeinde O, Schwenk JM, Wahlgren M, Fernandez-Reyes D, Nilsson P.
Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria.
PLoS Pathog. 2014 10(4):e1004038.
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260 Shoaie S, Karlsson F, Mardinoglu A, Nookaew I, Bordel S, Nielsen J.
Understanding the interactions between bacteria in the human gut through metabolic modeling.
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258 Boman K, Larsson AH, Segersten U, Kuteeva E, Johannesson H, Nodin B, Eberhard J, Uhlén M, Malmström PU, Jirström K.
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256 Sernbo S, Borrebaeck CA, Uhlén M, Jirström K, Ek S.
Nuclear T-STAR protein expression correlates with HER2 status, hormone receptor negativity and prolonged recurrence free survival in primary breast cancer and decreased cancer cell growth in vitro.
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255 Zong NC, Li H, Li H, Lam MP, Jimenez RC, Kim CS, Deng N, Kim AK, Choi JH, Zelaya I, Liem D, Meyer D, Odeberg J, Fang C, Lu HJ, Xu T, Weiss J, Duan H, Uhlen M, Yates JR, Apweiler R, Ge J, Hermjakob H, Ping P.
Integration of cardiac proteome biology and medicine by a specialized knowledgebase.
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254 Gremel G, Grannas K, Sutton LA, Pontén F, Zieba A.
In situ Protein Detection for Companion Diagnostics.
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253 Jansson L, Kampf C, Källskog O.
Functional stimulation of graft nerves has minor effects on insulin release from transplanted rat pancreatic islets.
Ups J Med Sci. 2013 118(4):209-16.
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252 Nilsson CL, Berven F, Selheim F, Liu H, Moskal JR, Kroes RA, Sulman EP, Conrad CA, Lang FF, Andrén PE, Nilsson A, Carlsohn E, Lilja H, Malm J, Fenyö D, Subramaniyam D, Wang X, Gonzales-Gonzales M, Dasilva N, Diez P, Fuentes M, Végvári Á, Sjödin K, Welinder C, Laurell T, Fehniger TE, Lindberg H, Rezeli M, Edula G, Hober S, Marko-Varga G.
Chromosome 19 annotations with disease speciation: a first report from the Global Research Consortium.
J Proteome Res. 2013 12(1):135-50.
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251 Malm J, Fehniger TE, Danmyr P, Végvári A, Welinder C, Lindberg H, Appelqvist R, Sjödin K, Wieslander E, Laurell T, Hober S, Berven FS, Fenyö D, Wang X, Andrén PE, Edula G, Carlsohn E, Fuentes M, Nilsson CL, Dahlbäck M, Rezeli M, Erlinge D, Marko-Varga G.
Developments in biobanking workflow standardization providing sample integrity and stability.
J Proteomics. 2013 95():38-45.
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250 Häggmark A, Byström S, Ayoglu B, Qundos U, Uhlén M, Khademi M, Olsson T, Schwenk JM, Nilsson P.
Antibody-based profiling of cerebrospinal fluid within multiple sclerosis.
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249 Ayoglu B, Häggmark A, Khademi M, Olsson T, Uhlén M, Schwenk JM, Nilsson P.
Autoantibody profiling in multiple sclerosis using arrays of human protein fragments.
Mol Cell Proteomics. 2013 12(9):2657-72.
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248 Drobin K, Nilsson P, Schwenk JM.
Highly multiplexed antibody suspension bead arrays for plasma protein profiling.
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Development of a coordinated allo T-cell and auto B-cell response against autosomal PTK2B after allogeneic hematopoietic stem cell transplantation.
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Profiling post-centrifugation delay of serum and plasma with antibody bead arrays.
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J Pathol Inform. 2013 4(Suppl):S14.
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Vandetanib combined with a p38 MAPK inhibitor synergistically reduces glioblastoma cell survival.
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A texture based pattern recognition approach to distinguish melanoma from non-melanoma cells in histopathological tissue microarray sections.
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241 Põlajeva J, Bergström T, Edqvist PH, Lundequist A, Sjösten A, Nilsson G, Smits A, Bergqvist M, Pontén F, Westermark B, Pejler G, Forsberg Nilsson K, Tchougounova E.
Glioma-derived macrophage migration inhibitory factor (MIF) promotes mast cell recruitment in a STAT5-dependent manner.
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Profiling of atherosclerotic lesions by gene and tissue microarrays reveals PCSK6 as a novel protease in unstable carotid atherosclerosis.
Arterioscler Thromb Vasc Biol. 2013 33(10):2432-43.
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Investigation of Molecular Alterations of AKT-3 in Triple Negative Breast Cancer.
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Integration of clinical data with a genome-scale metabolic model of the human adipocyte.
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European H16N3 gull influenza virus attaches to the human respiratory tract and eye.
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Heart research advances using database search engines, human protein atlas and the sydney heart bank.
Heart Lung Circ. 2013 22(10):819-26.
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Progesterone receptor negativity is an independent risk factor for relapse in patients with early stage endometrioid endometrial adenocarcinoma.
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Improving the diagnosis and management of neuroendocrine tumors: utilizing new advances in biomarker and molecular imaging science.
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Initial quantitative proteomic map of 28 mouse tissues using the SILAC mouse.
Mol Cell Proteomics. 2013 12(6):1709-22.
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Evaluation of Real-Time Immunohistochemistry and Interaction Map as an Alternative Objective Assessment of HER2 Expression in Human Breast Cancer Tissue.
Appl Immunohistochem Mol Morphol. 2013 Epub ahead of print
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FHOD1, a Formin Upregulated in Epithelial-Mesenchymal Transition, Participates in Cancer Cell Migration and Invasion.
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A study of embryonic stem cell-related proteins in human astrocytomas: Identification of Nanog as a predictor of survival.
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Majority of differentially expressed genes are down-regulated during malignant transformation in a four-stage model.
Proc Natl Acad Sci U S A. 2013 110(17):6853-8.
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CDK-mediated activation of the SCF(FBXO) (28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer.
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Acta Obstet Gynecol Scand. 2013 92(8):888-94.
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Antibodies Biotinylated Using a Synthetic Z-domain from Protein A Provide Stringent In Situ Protein Detection.
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RNA deep sequencing as a tool for selection of cell lines for systematic subcellular localization of all human proteins.
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