News Articles


Image of the month - ODF4 in spermatids

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How can sperm swim? The outer dense fiber of sperm tails 4 (gene: ODF4) is one of the proteins thought to be important for sperm tail movement that propels the sperm forward. Multiplex immunohistochemistry technique enabled us to examine the expression of this protein during sperm development (spermatogenesis) in more detail than ever before...Read more


HSP60 - From Stress to Success

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Proper three-dimensional structure of proteins is paramount to their function, and misfolded proteins not only lead to loss of that function but to aggregates that can disrupt cellular processes. In ideal conditions, proteins fold spontaneously into their native three-dimensional structures, driven by their amino acid sequence (Ellis, 1999). However, in the crowded and stressed environment of the cell, assistance is often required to avoid misfolding and aggregation. This week we highlight heat shock protein 60 (HSP60), pictured here in the mitochondria of U2OS cells. As a member of the class 1 chaperonin family, HSP60 assists in the folding of newly translated, imported, or denatured proteins in the mitochondrial matrix, particularly under conditions of stress such as high temperatures or UV light ( Hartl, 1996)...Read more


The roles of vaccine-induced SARS-CoV-2 NAbs and T cells in protection and disease

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In a study published in Molecular Therapy researchers from KTH among others have generated several different DNA vaccines selectively activating neutralizing antibodies (Nabs) and/or T cells and used them in different animal models to study their individual roles in the protection against severe SARS-CoV-2...Read more


A multi-omics strategy to discover and validate missing proteins in the ovary

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In a publication in Journal of Proteome Research transcriptomics and spatial proteomics were used to investigate and validate the expression of so-called missing proteins in the human ovary...Read more


Image of the month - PF4 in platelets

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Platelet factor 4 (gene: PF4) is a chemokine expressed by platelets (thrombocytes) - blood cell fragments that play a key role during blood clotting. Although its normal physiological role is not completely understood, PF4 is implicated in antimicrobial activity and life-threatening thrombosis caused by adenovirus vector covid-19 vaccines...Read more