Explore the cell type specificity of genes within human tissues

ERV3-1 - Skin

IYD - Thyroid

The Tissue Cell Type section contains cell type expression specificity predictions for all human protein coding genes, generated using integrated network analysis of publicly available bulk RNAseq data. A specificity classification is used to predict which genes are enriched in each constituent cell type within an individual tissue. The data can be explored on a tissue-by-tissue basis, together with in-house generated immunohistochemically stained tissue sections. In addition, a core cell type analysis focuses on the cell types found in all, or the majority, of the profiled tissues, e.g., endothelial cells or macrophages. Here, genes with predicted specificity in these core cell types in multiple tissues are detailed. More information about the specific content and data analysis in the section can be found in the Methods Summary.

Learn about:

if a gene is predicted to have cell type specificity within a given tissue
which genes have a common cell type specificity prediction within each tissue
the catalogue of genes with predicted specificity in core cell types across tissues

THE TISSUE CELL TYPE PROTEOMESⁱ

Selecting a tissue will show tissue information, the cell types analyzed and which genes had predicted specificity in each, together with example immunohistochemistry protein staining.

CORE CELL TYPE PROTEOMESⁱ

The cell types in this section are analyzed in many of the tissues profiled. Here, you can explore which genes have predicted enriched expression in these cell types, across multiple tissue types.

Endothelial cells

Smooth muscle cells

Fibroblasts

Macrophages

Neutrophils

Mast cells

T-cells

Plasma cells

TISSUE CELL TYPE SUMMARYⁱ

Tissue	Cell type	Very high	High	Moderate	Enriched
Adipose subcutaneous	Adipocytes (Subcutaneous)	515	70	20	605
	Endothelial cells	67	57	43	167
	Smooth muscle cells	156	95	80	331
	Adipose progenitor cells	25	112	103	240
	Macrophages	117	116	107	340
	Mast cells	13	8	15	36
	T-cells	10	71	80	161
	Plasma cells	26	62	12	100
Adipose visceral	Adipocytes (Visceral)	462	69	26	557
	Mesothelial cells	137	152	127	416
	Endothelial cells	46	65	104	215
	Smooth muscle cells	57	32	28	117
	Adipose progenitor cells	11	56	284	351
	Macrophages	78	72	72	222
	Neutrophils	34	17	13	64
	Mast cells	4	6	6	16
	T-cells	18	100	132	250
	Plasma cells	79	53	16	148
Breast	Breast glandular cells	1	30	250	270
	Breast glandular cells (progenitors)	3	5	20	28
	Breast myoepithelial cells	0	6	60	66
	Adipocytes (Breast)	316	171	125	612
	Endothelial cells	89	98	101	288
	Smooth muscle cells	0	4	27	31
	Fibroblasts	23	75	140	238
	Macrophages	51	34	41	126
	T-cells	13	70	125	208
	Plasma cells	121	77	29	227
Colon	Colon enterocytes	180	98	91	369
	Colon enteroendocrine cells	133	124	81	338
	Enteric glia cells	77	104	59	240
	Mitotic cells (Colon)	14	33	38	85
	Endothelial cells	5	61	153	219
	Smooth muscle cells	94	46	26	166
	Fibroblasts	0	5	37	42
	Macrophages	26	40	77	143
	Neutrophils	7	25	35	67
	Mast cells	9	12	8	29
	T-cells	2	28	78	108
	Plasma cells	12	47	55	114
Heart muscle	Cardiomyocytes	1	183	732	916
	Mitotic cells (Heart)	7	15	34	56
	Endothelial cells	9	44	138	191
	Smooth muscle cells	2	10	26	38
	Fibroblasts	12	98	251	361
	Macrophages	3	21	111	135
	Neutrophils	11	22	19	52
	T-cells	6	27	42	75
	Plasma cells	28	37	13	78
Kidney	Podocytes	43	37	32	112
	Proximal tubular cells	372	185	158	657
	Ascending Loop of Henle cells	8	21	42	71
	Intercalated cells	12	32	31	75
	Endothelial cells	14	48	227	289
	Fibroblasts	4	65	214	283
	Macrophages	18	40	32	90
	T-cells	0	7	105	112
	Plasma cells	0	1	88	89
Liver	Hepatocytes	417	341	511	1264
	Cholangiocyte	3	16	38	57
	NK-cells (Liver)	8	5	20	33
	Erythroid cells	21	5	2	28
	Endothelial cells	7	47	276	330
	Hepatic stellate cells	52	111	153	316
	Kupffer cells	0	14	83	97
	Neutrophils	17	12	23	52
	T-cells	1	18	54	73
	Plasma cells	14	89	40	143
Lung	Respiratory ciliated cells	591	53	37	681
	Alveolar cells type 1	43	41	48	132
	Alveolar cells type 2	20	122	221	363
	Mitotic cells (Lung)	111	26	16	153
	NK-cells (Lung)	3	13	39	55
	B-cells	4	1	6	11
	Endothelial cells	0	9	88	97
	Smooth muscle cells	14	13	36	63
	Fibroblasts	27	64	162	253
	Macrophages	4	51	105	160
	Neutrophils	61	52	47	160
	Mast cells	10	4	3	17
	T-cells	6	29	54	89
	Plasma cells	166	15	4	185
Pancreas	Alpha cells	37	98	86	221
	Beta cells	57	82	61	200
	Ductal cells	6	24	85	115
	Exocrine glandular cells	38	1	0	39
	Endothelial cells	0	10	37	47
	Fibroblasts	0	12	60	72
	Macrophages	1	11	74	86
	T-cells	0	7	31	38
	Plasma cells	70	48	23	141
Prostate	Prostate glandular cells	261	121	56	438
	Prostate basal glandular cells	4	26	75	105
	Urothelial cells	19	54	86	159
	Endothelial cells	55	55	67	177
	Smooth muscle cells	126	117	108	351
	Fibroblasts	59	94	132	285
	Macrophages	23	42	31	96
	T-cells	0	32	150	182
	Plasma cells	9	89	45	143
Skeletal muscle	Skeletal myocytes	63	107	181	329
	Endothelial cells	4	37	196	237
	Smooth muscle cells	3	12	26	41
	Fibroblasts	0	53	285	338
	Macrophages	25	54	97	176
	Neutrophils	13	10	12	35
	Plasma cells	23	32	14	69
Skin	Keratinocyte (other)	125	257	355	737
	Keratinocyte (granular)	91	61	56	208
	Melanocytes	9	3	5	17
	Hair cortex cells	0	27	21	48
	Inner root sheath cells	0	4	18	22
	Outer root sheath cells	1	14	104	119
	Sebaceous gland cells	92	63	51	206
	Eccrine sweat gland cells	61	73	112	246
	Langerhans cells	2	3	15	20
	Adipocytes (Skin)	2	10	14	26
	Mitotic cells (Skin)	68	47	75	190
	Endothelial cells	3	37	173	213
	Smooth muscle cells	6	13	17	36
	Fibroblasts	4	23	120	147
	Macrophages	2	14	40	56
	Mast cells	0	6	6	12
	T-cells	3	13	42	58
	Plasma cells	38	50	11	99
Stomach	Parietal cells	1	25	48	74
	Chief cells	0	5	51	56
	Gastric mucous cells	0	42	337	379
	Gastric enteroendocrine cells	0	15	32	47
	Mitotic cells (Stomach)	63	57	50	170
	Endothelial cells	0	5	79	84
	Fibroblasts	0	5	161	166
	Macrophages	10	30	114	154
	Neutrophils	4	5	13	22
	T-cells	0	0	23	23
	Plasma cells	0	0	186	186
Testis	Spermatogonia	9	32	117	158
	Spermatocytes	23	54	111	188
	Early spermatids	26	237	494	757
	Late spermatids	29	169	386	584
	Sertoli cells	50	188	376	614
	Leydig cells	0	4	16	20
	Peritubular cells	0	4	38	42
	Endothelial cells	0	12	97	109
	Macrophages	1	5	54	60
Thyroid	Parafollicular cells	30	13	4	47
	Thyroid glandular cells	718	548	332	1598
	Mitotic cells (Thyroid)	33	25	11	69
	Endothelial cells	8	25	37	70
	Smooth muscle cells	15	32	39	86
	Fibroblasts	11	126	326	463
	Macrophages	45	32	40	117
	Neutrophils	19	12	5	36
	T-cells	35	119	196	350
	Plasma cells	99	39	44	182