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Proteins detected in plasma using proximity extension assay

Proximity extension assays (PEA) based on Olink was performed for 1456 proteins based on a longitudinal wellness study covering 76 individuals for two years with three visits at month 0, month 18 and month 24 (visits 1-3). The results are presented as Normalized Protein eXpression (NPX) for the individual genes corresponding to these proteins for all females and males respectively.

Below is a summary of the variation between individuals and within individuals for these 1456 proteins calculated as the mean coefficient of variation (CV) for each protein within each visit and across all analyzed individuals (n=76), and as the mean CV for each protein within each individual across all three visits respectively.

Gene Gene description Variation between individuals Variation within individuals
ARNT Aryl hydrocarbon receptor nuclear translocator 0.52 0.2
GH2 Growth hormone 2 0.49 0.08
GFOD2 Glucose-fructose oxidoreductase domain containing 2 0.48 0.07
TPT1 Tumor protein, translationally-controlled 1 0.45 0.1
IL5 Interleukin 5 0.44 0.14
IL1A Interleukin 1 alpha 0.43 0.21
KLK12 Kallikrein related peptidase 12 0.4 0.06
ARID4B AT-rich interaction domain 4B 0.38 0.1
WAS WASP actin nucleation promoting factor 0.35 0.23
PNPT1 Polyribonucleotide nucleotidyltransferase 1 0.35 0.08
CEP164 Centrosomal protein 164 0.35 0.12
GHRHR Growth hormone releasing hormone receptor 0.35 0.08
IKZF2 IKAROS family zinc finger 2 0.35 0.09
TCL1B TCL1 family AKT coactivator B 0.35 0.13
LYPD1 LY6/PLAUR domain containing 1 0.34 0.08
IL18RAP Interleukin 18 receptor accessory protein 0.34 0.05
ATF2 Activating transcription factor 2 0.33 0.09
CRX Cone-rod homeobox 0.32 0.1
TDGF1 Teratocarcinoma-derived growth factor 1 0.32 0.03
PM20D1 Peptidase M20 domain containing 1 0.31 0.04
IL10RA Interleukin 10 receptor subunit alpha 0.31 0.08
IL24 Interleukin 24 0.31 0.11
HSP90B1 Heat shock protein 90 beta family member 1 0.3 0.06
FKBP1B FKBP prolyl isomerase 1B 0.3 0.25
DUSP3 Dual specificity phosphatase 3 0.3 0.1
EPHA10 EPH receptor A10 0.3 0.08
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Leptin example

Visit


Figure 1 Protein profiles of Leptin shown with the individual concentrations across three visits over two years and the median levels for males and females, respectively.

Figure 2 A summary of the results for females and males as "violin" plots showing the distribution of protein levels of Leptin across the individuals for each visit. These plots are shown for all the 1456 proteins on respective gene page accessed though the links in the Table above.

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.