Single cell type - MAD1L1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MAD1L1
Gene descriptionⁱ Full gene name according to HGNC.	Mitotic arrest deficient 1 like 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Late spermatids, Early spermatids)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Late spermatids, Early spermatids)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

MAD1L1 is part of cluster 31 Spermatids - Spermatogenesis with confidenceⁱ 1
413 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ACAP1	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1	0.8779	31
LIN28A	Lin-28 homolog A	0.8308	31
PGK2	Phosphoglycerate kinase 2	0.8297	31
TSGA13	Testis specific 13	0.8263	31
ADGRD2	Adhesion G protein-coupled receptor D2	0.8114	31
TMCO5A	Transmembrane and coiled-coil domains 5A	0.8107	31
LRRC27	Leucine rich repeat containing 27	0.8071	31
PMFBP1	Polyamine modulated factor 1 binding protein 1	0.8036	31
LEMD1	LEM domain containing 1	0.7965	31
PRM2	Protamine 2	0.7923	31
C10orf53	Chromosome 10 open reading frame 53	0.7917	31
GAPDHS	Glyceraldehyde-3-phosphate dehydrogenase, spermatogenic	0.7915	31
TMEM31	Transmembrane protein 31	0.7864	31
ACTL7A	Actin like 7A	0.7841	31
OR5H6	Olfactory receptor family 5 subfamily H member 6	0.7836	31

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	9.3 nTPM
Breast	10.2 nTPM
Adipose tissue	8.3 nTPM

Alveolar cells type 1	3.2 nTPM
Lung	3.2 nTPM

Alveolar cells type 2	10.4 nTPM
Lung	10.4 nTPM

Astrocytes	12.1 nTPM
Brain	12.1 nTPM

B-cells	33.8 nTPM
PBMC	64.2 nTPM
Colon	54.3 nTPM
Adipose tissue	46.7 nTPM
Kidney	33.4 nTPM
Spleen	31.1 nTPM
Liver	24.6 nTPM
Stomach	24.1 nTPM
Lymph node	21.7 nTPM
Bone marrow	20.4 nTPM
Breast	17.3 nTPM

Dendritic cells	35.7 nTPM
Breast	55.4 nTPM
Adipose tissue	31.9 nTPM
PBMC	20.0 nTPM

Endothelial cells	10.7 nTPM
Eye	19.4 nTPM
Ovary	16.3 nTPM
Testis	13.9 nTPM
Placenta	13.7 nTPM
Skin	13.7 nTPM
Pancreas	11.6 nTPM
Endometrium	11.4 nTPM
Skeletal muscle	10.6 nTPM
Breast	9.7 nTPM
Prostate	8.9 nTPM
Liver	8.2 nTPM
Heart muscle	7.3 nTPM
Esophagus	5.2 nTPM
Lung	0.0 nTPM

Fibroblasts	11.4 nTPM
Ovary	19.2 nTPM
Skin	16.9 nTPM
Placenta	15.6 nTPM
Esophagus	12.0 nTPM
Adipose tissue	11.7 nTPM
Skeletal muscle	11.1 nTPM
Breast	11.1 nTPM
Stomach	10.4 nTPM
Prostate	6.2 nTPM
Heart muscle	6.0 nTPM
Lung	5.6 nTPM

Intestinal goblet cells	9.4 nTPM
Colon	12.9 nTPM
Rectum	8.2 nTPM
Small intestine	7.2 nTPM

Macrophages	28.2 nTPM
Prostate	45.8 nTPM
Adipose tissue	43.3 nTPM
Ovary	43.0 nTPM
Testis	36.0 nTPM
Kidney	31.8 nTPM
Pancreas	30.7 nTPM
Skeletal muscle	30.7 nTPM
Breast	29.9 nTPM
Endometrium	27.3 nTPM
Bone marrow	26.2 nTPM
Stomach	23.5 nTPM
Esophagus	20.4 nTPM
Spleen	18.6 nTPM
Lung	15.6 nTPM
PBMC	0.0 nTPM

Paneth cells	7.9 nTPM
Colon	13.2 nTPM
Rectum	6.7 nTPM
Small intestine	3.7 nTPM

Plasma cells	14.9 nTPM
Spleen	21.4 nTPM
Bone marrow	18.2 nTPM
Adipose tissue	13.0 nTPM
Esophagus	12.3 nTPM
Stomach	9.7 nTPM

Respiratory ciliated cells	6.6 nTPM
Lung	7.3 nTPM
Bronchus	6.0 nTPM

Smooth muscle cells	10.2 nTPM
Pancreas	21.0 nTPM
Ovary	14.6 nTPM
Prostate	11.0 nTPM
Skin	10.4 nTPM
Adipose tissue	9.3 nTPM
Breast	9.3 nTPM
Skeletal muscle	9.2 nTPM
Endometrium	8.6 nTPM
Bronchus	7.5 nTPM
Heart muscle	6.2 nTPM
Esophagus	4.6 nTPM

T-cells	43.1 nTPM
Ovary	100.1 nTPM
Liver	67.2 nTPM
PBMC	63.3 nTPM
Bone marrow	53.7 nTPM
Kidney	52.0 nTPM
Breast	44.0 nTPM
Skin	41.9 nTPM
Spleen	39.9 nTPM
Skeletal muscle	35.3 nTPM
Prostate	33.1 nTPM
Esophagus	32.8 nTPM
Stomach	32.8 nTPM
Adipose tissue	32.4 nTPM
Colon	29.0 nTPM
Lymph node	28.0 nTPM
Lung	25.8 nTPM
Endometrium	22.3 nTPM

Basal keratinocytes	17.6 nTPM
Skin	17.6 nTPM

Basal respiratory cells	14.0 nTPM
Bronchus	14.0 nTPM

Basal squamous epithelial cells	15.4 nTPM
Esophagus	15.4 nTPM

Cholangiocytes	14.3 nTPM
Liver	14.3 nTPM

Undifferentiated cells	8.8 nTPM
Colon	13.1 nTPM
Small intestine	6.9 nTPM
Rectum	6.3 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC