Single cell type - LASP1 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	LASP1
Gene descriptionⁱ Full gene name according to HGNC.	LIM and SH3 protein 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Spermatids - Spermatogenesis (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids, Proximal enterocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids, Proximal enterocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

LASP1 is part of cluster 25 Spermatids - Spermatogenesis with confidenceⁱ 1
458 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
CPTP	Ceramide-1-phosphate transfer protein	0.6852	25
FIBP	FGF1 intracellular binding protein	0.6551	25
TREH	Trehalase	0.6480	45
ZNF213	Zinc finger protein 213	0.6337	31
OGFOD2	2-oxoglutarate and iron dependent oxygenase domain containing 2	0.6300	25
CRAT	Carnitine O-acetyltransferase	0.6263	25
NBR1	NBR1 autophagy cargo receptor	0.6072	25
ZNF688	Zinc finger protein 688	0.6041	31
DGCR6L	DiGeorge syndrome critical region gene 6 like	0.5948	25
TMEM120A	Transmembrane protein 120A	0.5924	25
ACE	Angiotensin I converting enzyme	0.5869	45
REEP6	Receptor accessory protein 6	0.5781	25
SHBG	Sex hormone binding globulin	0.5777	25
FBXW5	F-box and WD repeat domain containing 5	0.5707	25
GPR137	G protein-coupled receptor 137	0.5707	25

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	54.5 nTPM
Adipose tissue	55.6 nTPM
Breast	53.5 nTPM

Alveolar cells type 1	41.7 nTPM
Lung	41.7 nTPM

Alveolar cells type 2	27.6 nTPM
Lung	27.6 nTPM

Astrocytes	17.6 nTPM
Brain	17.6 nTPM

B-cells	41.8 nTPM
Colon	68.7 nTPM
Lymph node	62.8 nTPM
Breast	50.9 nTPM
PBMC	44.2 nTPM
Spleen	36.4 nTPM
Liver	34.9 nTPM
Kidney	33.4 nTPM
Bone marrow	31.9 nTPM
Stomach	29.0 nTPM
Adipose tissue	25.5 nTPM

Dendritic cells	69.5 nTPM
Adipose tissue	75.3 nTPM
Breast	73.3 nTPM
PBMC	59.8 nTPM

Endothelial cells	54.3 nTPM
Liver	89.0 nTPM
Ovary	78.8 nTPM
Lung	74.8 nTPM
Esophagus	74.7 nTPM
Placenta	69.3 nTPM
Skin	57.5 nTPM
Breast	57.1 nTPM
Prostate	56.6 nTPM
Skeletal muscle	52.2 nTPM
Endometrium	41.4 nTPM
Testis	38.2 nTPM
Pancreas	34.7 nTPM
Eye	25.9 nTPM
Heart muscle	10.5 nTPM

Enteroendocrine cells	86.5 nTPM
Rectum	102.0 nTPM
Colon	71.0 nTPM

Fibroblasts	50.1 nTPM
Placenta	90.4 nTPM
Esophagus	67.8 nTPM
Skeletal muscle	66.8 nTPM
Adipose tissue	66.5 nTPM
Skin	59.3 nTPM
Stomach	52.0 nTPM
Ovary	50.8 nTPM
Breast	48.3 nTPM
Lung	26.8 nTPM
Prostate	16.9 nTPM
Heart muscle	5.1 nTPM

Intestinal goblet cells	101.9 nTPM
Small intestine	136.7 nTPM
Rectum	91.7 nTPM
Colon	77.2 nTPM

Macrophages	71.9 nTPM
Pancreas	109.7 nTPM
Spleen	107.8 nTPM
Esophagus	105.4 nTPM
Prostate	80.2 nTPM
Bone marrow	72.4 nTPM
Breast	71.7 nTPM
Lung	68.9 nTPM
PBMC	68.2 nTPM
Ovary	64.5 nTPM
Skeletal muscle	61.1 nTPM
Adipose tissue	60.5 nTPM
Stomach	58.6 nTPM
Endometrium	56.4 nTPM
Kidney	52.9 nTPM
Testis	39.5 nTPM

Paneth cells	116.4 nTPM
Colon	141.6 nTPM
Rectum	117.3 nTPM
Small intestine	90.1 nTPM

Plasma cells	32.8 nTPM
Adipose tissue	49.1 nTPM
Stomach	33.3 nTPM
Spleen	32.5 nTPM
Bone marrow	24.7 nTPM
Esophagus	24.6 nTPM

Respiratory ciliated cells	57.3 nTPM
Bronchus	79.7 nTPM
Lung	35.0 nTPM

Smooth muscle cells	53.4 nTPM
Ovary	95.7 nTPM
Endometrium	82.5 nTPM
Pancreas	75.5 nTPM
Skeletal muscle	75.0 nTPM
Adipose tissue	62.5 nTPM
Esophagus	62.0 nTPM
Breast	44.1 nTPM
Skin	32.7 nTPM
Prostate	25.4 nTPM
Bronchus	18.9 nTPM
Heart muscle	12.8 nTPM

Basal prostatic cells	21.5 nTPM
Prostate	21.5 nTPM

Basal respiratory cells	26.0 nTPM
Bronchus	26.0 nTPM

Basal squamous epithelial cells	51.8 nTPM
Esophagus	51.8 nTPM

Cholangiocytes	55.8 nTPM
Liver	55.8 nTPM

T-cells	63.4 nTPM
Colon	91.2 nTPM
Liver	88.1 nTPM
PBMC	76.1 nTPM
Bone marrow	74.0 nTPM
Skeletal muscle	73.4 nTPM
Stomach	70.0 nTPM
Breast	69.3 nTPM
Endometrium	68.7 nTPM
Skin	67.2 nTPM
Spleen	60.1 nTPM
Kidney	58.9 nTPM
Adipose tissue	55.3 nTPM
Lymph node	52.5 nTPM
Esophagus	52.4 nTPM
Ovary	46.7 nTPM
Lung	41.0 nTPM
Prostate	33.1 nTPM

Undifferentiated cells	97.8 nTPM
Small intestine	112.3 nTPM
Rectum	98.0 nTPM
Colon	83.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC