Single cell type - CASP10 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CASP10
Gene descriptionⁱ Full gene name according to HGNC.	Caspase 10
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Human disease related genes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Intestinal epithelial cells - Unknown function (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Distal enterocytes, Plasma cells, Paneth cells, NK-cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (HUVEC TERT2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Distal enterocytes, Plasma cells, Paneth cells, NK-cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CASP10 is part of cluster 53 Intestinal epithelial cells - Unknown function with confidenceⁱ 1
611 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
BATF2	Basic leucine zipper ATF-like transcription factor 2	0.7069	53
TRIM40	Tripartite motif containing 40	0.6635	53
CASP5	Caspase 5	0.6533	53
SAMD9	Sterile alpha motif domain containing 9	0.6364	53
PLEC	Plectin	0.6189	53
RSAD2	Radical S-adenosyl methionine domain containing 2	0.6073	53
SLCO2A1	Solute carrier organic anion transporter family member 2A1	0.6003	14
CGN	Cingulin	0.5849	53
TRIM15	Tripartite motif containing 15	0.5786	53
TRIM31	Tripartite motif containing 31	0.5782	53
DDX60	DExD/H-box helicase 60	0.5769	53
HLA-E	Major histocompatibility complex, class I, E	0.5766	14
GCNT3	Glucosaminyl (N-acetyl) transferase 3, mucin type	0.5710	53
SAMD9L	Sterile alpha motif domain containing 9 like	0.5702	14
PLAC8	Placenta associated 8	0.5639	53

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	20.7 nTPM
Adipose tissue	20.7 nTPM
Breast	20.7 nTPM

Alveolar cells type 1	19.2 nTPM
Lung	19.2 nTPM

Alveolar cells type 2	10.0 nTPM
Lung	10.0 nTPM

Astrocytes	0.3 nTPM
Brain	0.3 nTPM

B-cells	15.8 nTPM
Liver	36.0 nTPM
Adipose tissue	31.1 nTPM
Breast	29.4 nTPM
Bone marrow	13.9 nTPM
PBMC	11.5 nTPM
Spleen	11.1 nTPM
Lymph node	10.9 nTPM
Stomach	9.6 nTPM
Colon	4.8 nTPM
Kidney	0.0 nTPM

Dendritic cells	20.5 nTPM
Adipose tissue	34.7 nTPM
Breast	14.9 nTPM
PBMC	12.0 nTPM

Endothelial cells	29.7 nTPM
Heart muscle	51.3 nTPM
Lung	49.9 nTPM
Skeletal muscle	43.5 nTPM
Skin	41.2 nTPM
Endometrium	37.0 nTPM
Ovary	35.2 nTPM
Placenta	29.6 nTPM
Testis	26.1 nTPM
Esophagus	22.6 nTPM
Liver	22.0 nTPM
Breast	21.7 nTPM
Eye	21.0 nTPM
Prostate	11.6 nTPM
Pancreas	3.9 nTPM

Fibroblasts	4.2 nTPM
Lung	14.5 nTPM
Heart muscle	6.5 nTPM
Skin	5.6 nTPM
Stomach	4.4 nTPM
Placenta	2.7 nTPM
Breast	2.5 nTPM
Skeletal muscle	2.4 nTPM
Ovary	2.2 nTPM
Adipose tissue	2.2 nTPM
Esophagus	1.5 nTPM
Prostate	1.2 nTPM

Intestinal goblet cells	21.6 nTPM
Colon	31.5 nTPM
Small intestine	19.1 nTPM
Rectum	14.3 nTPM

Macrophages	16.2 nTPM
Skeletal muscle	26.8 nTPM
Adipose tissue	26.4 nTPM
Esophagus	25.2 nTPM
Testis	24.4 nTPM
Ovary	20.1 nTPM
Bone marrow	20.0 nTPM
Lung	19.9 nTPM
Kidney	18.9 nTPM
Endometrium	14.0 nTPM
Breast	13.7 nTPM
Spleen	12.5 nTPM
Prostate	10.3 nTPM
Stomach	8.8 nTPM
Pancreas	2.5 nTPM
PBMC	0.0 nTPM

Paneth cells	44.5 nTPM
Colon	88.9 nTPM
Small intestine	26.3 nTPM
Rectum	18.3 nTPM

Plasma cells	49.7 nTPM
Stomach	75.9 nTPM
Esophagus	61.7 nTPM
Bone marrow	42.9 nTPM
Adipose tissue	36.1 nTPM
Spleen	31.9 nTPM

Respiratory ciliated cells	24.4 nTPM
Bronchus	32.8 nTPM
Lung	16.0 nTPM

Smooth muscle cells	2.2 nTPM
Bronchus	6.6 nTPM
Heart muscle	3.6 nTPM
Pancreas	2.5 nTPM
Skin	2.4 nTPM
Endometrium	2.4 nTPM
Breast	2.3 nTPM
Esophagus	1.5 nTPM
Skeletal muscle	1.0 nTPM
Adipose tissue	0.9 nTPM
Ovary	0.7 nTPM
Prostate	0.4 nTPM

T-cells	12.9 nTPM
Liver	21.4 nTPM
Lung	19.7 nTPM
PBMC	18.4 nTPM
Endometrium	18.0 nTPM
Ovary	17.8 nTPM
Skeletal muscle	15.9 nTPM
Kidney	14.4 nTPM
Prostate	14.2 nTPM
Esophagus	13.1 nTPM
Colon	11.4 nTPM
Bone marrow	11.3 nTPM
Adipose tissue	10.1 nTPM
Spleen	9.1 nTPM
Lymph node	8.0 nTPM
Skin	6.9 nTPM
Breast	6.7 nTPM
Stomach	2.8 nTPM

Basal keratinocytes	6.0 nTPM
Skin	6.0 nTPM

Basal respiratory cells	10.6 nTPM
Bronchus	10.6 nTPM

Cholangiocytes	8.6 nTPM
Liver	8.6 nTPM

Collecting duct cells	9.2 nTPM
Kidney	9.2 nTPM

Undifferentiated cells	16.4 nTPM
Colon	22.7 nTPM
Small intestine	15.1 nTPM
Rectum	11.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC