Single cell type - POLDIP2 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	POLDIP2
Gene descriptionⁱ Full gene name according to HGNC.	DNA polymerase delta interacting protein 2
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Basic cellular processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells, Distal tubular cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (CACO-2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells, Distal tubular cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

POLDIP2 is part of cluster 39 Non-specific - Basic cellular processes with confidenceⁱ 0.95
586 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
POLR3H	RNA polymerase III subunit H	0.5838	25
MRPS7	Mitochondrial ribosomal protein S7	0.5555	25
NDUFS8	NADH:ubiquinone oxidoreductase core subunit S8	0.5441	39
TSFM	Ts translation elongation factor, mitochondrial	0.5385	39
GTF3C6	General transcription factor IIIC subunit 6	0.5270	39
PSMD6	Proteasome 26S subunit, non-ATPase 6	0.5263	10
THOC5	THO complex 5	0.5137	25
MRPS16	Mitochondrial ribosomal protein S16	0.5134	39
TACO1	Translational activator of cytochrome c oxidase I	0.5128	67
RMDN1	Regulator of microtubule dynamics 1	0.5002	39
ANAPC11	Anaphase promoting complex subunit 11	0.5000	25
ZC3H15	Zinc finger CCCH-type containing 15	0.4943	52
TRAPPC2L	Trafficking protein particle complex 2 like	0.4926	25
GHITM	Growth hormone inducible transmembrane protein	0.4884	39
DNAJC30	DnaJ heat shock protein family (Hsp40) member C30	0.4879	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	20.4 nTPM
Breast	22.6 nTPM
Adipose tissue	18.2 nTPM

Alveolar cells type 1	9.6 nTPM
Lung	9.6 nTPM

Alveolar cells type 2	18.1 nTPM
Lung	18.1 nTPM

Astrocytes	13.1 nTPM
Brain	13.1 nTPM

B-cells	27.7 nTPM
Liver	69.4 nTPM
Kidney	52.4 nTPM
Spleen	27.6 nTPM
Stomach	26.8 nTPM
Lymph node	22.2 nTPM
PBMC	20.0 nTPM
Bone marrow	19.6 nTPM
Breast	14.7 nTPM
Colon	12.8 nTPM
Adipose tissue	11.1 nTPM

Dendritic cells	17.0 nTPM
PBMC	20.0 nTPM
Breast	18.2 nTPM
Adipose tissue	12.7 nTPM

Endothelial cells	29.1 nTPM
Pancreas	61.8 nTPM
Placenta	38.7 nTPM
Ovary	36.6 nTPM
Breast	33.8 nTPM
Skin	33.0 nTPM
Prostate	28.3 nTPM
Testis	28.2 nTPM
Heart muscle	26.1 nTPM
Esophagus	24.4 nTPM
Eye	23.5 nTPM
Skeletal muscle	22.8 nTPM
Liver	19.2 nTPM
Endometrium	18.1 nTPM
Lung	12.5 nTPM

Fibroblasts	29.5 nTPM
Placenta	49.9 nTPM
Ovary	46.4 nTPM
Heart muscle	43.8 nTPM
Stomach	37.1 nTPM
Esophagus	27.6 nTPM
Skin	26.4 nTPM
Adipose tissue	24.1 nTPM
Breast	21.5 nTPM
Prostate	20.5 nTPM
Skeletal muscle	18.5 nTPM
Lung	8.9 nTPM

Intestinal goblet cells	42.4 nTPM
Rectum	48.2 nTPM
Colon	40.7 nTPM
Small intestine	38.2 nTPM

Macrophages	25.6 nTPM
Pancreas	58.7 nTPM
Kidney	45.3 nTPM
Ovary	44.0 nTPM
Testis	35.5 nTPM
Bone marrow	31.2 nTPM
Prostate	28.7 nTPM
Esophagus	25.2 nTPM
Spleen	19.7 nTPM
Breast	19.3 nTPM
Skeletal muscle	17.7 nTPM
Adipose tissue	16.6 nTPM
Endometrium	14.7 nTPM
Stomach	14.7 nTPM
Lung	12.1 nTPM
PBMC	0.0 nTPM

Paneth cells	37.6 nTPM
Rectum	53.1 nTPM
Small intestine	30.0 nTPM
Colon	29.6 nTPM

Plasma cells	46.1 nTPM
Spleen	98.2 nTPM
Bone marrow	70.9 nTPM
Stomach	42.6 nTPM
Esophagus	12.3 nTPM
Adipose tissue	6.4 nTPM

Respiratory ciliated cells	13.5 nTPM
Bronchus	22.6 nTPM
Lung	4.4 nTPM

Smooth muscle cells	47.0 nTPM
Pancreas	112.4 nTPM
Bronchus	108.5 nTPM
Heart muscle	50.2 nTPM
Esophagus	46.5 nTPM
Ovary	43.0 nTPM
Skin	30.7 nTPM
Prostate	30.0 nTPM
Skeletal muscle	28.7 nTPM
Breast	26.8 nTPM
Adipose tissue	23.1 nTPM
Endometrium	16.5 nTPM

T-cells	22.5 nTPM
Kidney	35.6 nTPM
Liver	34.3 nTPM
Stomach	32.4 nTPM
Colon	31.8 nTPM
Spleen	28.3 nTPM
Lymph node	28.2 nTPM
PBMC	28.1 nTPM
Esophagus	26.2 nTPM
Bone marrow	23.5 nTPM
Skin	22.6 nTPM
Skeletal muscle	16.7 nTPM
Breast	15.4 nTPM
Prostate	14.2 nTPM
Ovary	13.4 nTPM
Endometrium	11.8 nTPM
Lung	10.6 nTPM
Adipose tissue	9.4 nTPM

Basal keratinocytes	27.5 nTPM
Skin	27.5 nTPM

Basal prostatic cells	32.5 nTPM
Prostate	32.5 nTPM

Basal respiratory cells	61.6 nTPM
Bronchus	61.6 nTPM

Cholangiocytes	62.9 nTPM
Liver	62.9 nTPM

Undifferentiated cells	66.3 nTPM
Colon	75.9 nTPM
Rectum	62.2 nTPM
Small intestine	60.8 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC