Single cell type - CD79B - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CD79B
Gene descriptionⁱ Full gene name according to HGNC.	CD79b molecule
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes CD markers Disease related genes FDA approved drug targets Human disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	B-cells - Immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (B-cells)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (naive B-cell, memory B-cell)
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Cell line enhanced (Daudi, REH, U-698)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (B-cells)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

CD79B is part of cluster 57 B-cells - Immune response with confidenceⁱ 1
204 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
FCRLA	Fc receptor like A	0.9333	57
P2RX5	Purinergic receptor P2X 5	0.9248	57
CNR2	Cannabinoid receptor 2	0.9234	57
BTLA	B and T lymphocyte associated	0.9138	57
BLK	BLK proto-oncogene, Src family tyrosine kinase	0.9135	57
TNFRSF13C	TNF receptor superfamily member 13C	0.8990	57
FCRL2	Fc receptor like 2	0.8840	57
FCER2	Fc fragment of IgE receptor II	0.8800	57
CD37	CD37 molecule	0.8778	57
MS4A1	Membrane spanning 4-domains A1	0.8775	57
TLR10	Toll like receptor 10	0.8707	57
VPREB3	V-set pre-B cell surrogate light chain 3	0.8695	57
LCN8	Lipocalin 8	0.8608	57
FCRL1	Fc receptor like 1	0.8580	57
BANK1	B cell scaffold protein with ankyrin repeats 1	0.8413	57

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	24.9 nTPM
Breast	30.8 nTPM
Adipose tissue	18.9 nTPM

Alveolar cells type 1	0.0 nTPM
Lung	0.0 nTPM

Alveolar cells type 2	1.3 nTPM
Lung	1.3 nTPM

Astrocytes	0.0 nTPM
Brain	0.0 nTPM

Basal keratinocytes	4.5 nTPM
Skin	4.5 nTPM

B-cells	491.9 nTPM
Kidney	1418.8 nTPM
PBMC	1203.4 nTPM
Bone marrow	627.9 nTPM
Liver	374.4 nTPM
Lymph node	310.4 nTPM
Spleen	258.9 nTPM
Colon	218.9 nTPM
Breast	198.0 nTPM
Stomach	169.0 nTPM
Adipose tissue	139.3 nTPM

Dendritic cells	24.2 nTPM
PBMC	27.9 nTPM
Breast	24.1 nTPM
Adipose tissue	20.5 nTPM

Endothelial cells	25.2 nTPM
Skin	72.0 nTPM
Skeletal muscle	51.0 nTPM
Esophagus	49.2 nTPM
Breast	43.6 nTPM
Prostate	34.8 nTPM
Placenta	24.5 nTPM
Heart muscle	24.1 nTPM
Endometrium	17.8 nTPM
Liver	13.7 nTPM
Ovary	12.7 nTPM
Pancreas	7.7 nTPM
Testis	2.4 nTPM
Eye	0.0 nTPM
Lung	0.0 nTPM

Fibroblasts	3.3 nTPM
Skin	9.4 nTPM
Placenta	6.4 nTPM
Prostate	4.8 nTPM
Esophagus	4.0 nTPM
Lung	3.4 nTPM
Stomach	3.0 nTPM
Breast	2.5 nTPM
Skeletal muscle	1.4 nTPM
Heart muscle	0.8 nTPM
Adipose tissue	0.4 nTPM
Ovary	0.2 nTPM

Intestinal goblet cells	0.4 nTPM
Rectum	1.1 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Macrophages	13.4 nTPM
Kidney	58.2 nTPM
Bone marrow	32.4 nTPM
Skeletal muscle	24.6 nTPM
PBMC	13.6 nTPM
Adipose tissue	12.0 nTPM
Stomach	11.7 nTPM
Testis	10.5 nTPM
Esophagus	7.9 nTPM
Lung	7.2 nTPM
Spleen	7.2 nTPM
Breast	6.8 nTPM
Endometrium	4.1 nTPM
Ovary	2.9 nTPM
Prostate	2.2 nTPM
Pancreas	0.0 nTPM

Paneth cells	0.1 nTPM
Rectum	0.4 nTPM
Colon	0.0 nTPM
Small intestine	0.0 nTPM

Plasma cells	99.6 nTPM
Spleen	141.7 nTPM
Esophagus	110.8 nTPM
Bone marrow	110.4 nTPM
Stomach	102.3 nTPM
Adipose tissue	32.8 nTPM

Respiratory ciliated cells	0.0 nTPM
Lung	0.0 nTPM
Bronchus	0.0 nTPM

Smooth muscle cells	5.4 nTPM
Skeletal muscle	11.3 nTPM
Breast	11.0 nTPM
Ovary	9.7 nTPM
Heart muscle	6.1 nTPM
Skin	5.9 nTPM
Adipose tissue	5.8 nTPM
Esophagus	4.6 nTPM
Prostate	1.9 nTPM
Pancreas	1.6 nTPM
Endometrium	1.5 nTPM
Bronchus	0.0 nTPM

Early spermatids	0.6 nTPM
Testis	0.6 nTPM

Endometrial stromal cells	1.0 nTPM
Endometrium	1.0 nTPM

T-cells	27.0 nTPM
Ovary	48.9 nTPM
Kidney	48.0 nTPM
Liver	45.9 nTPM
Esophagus	45.9 nTPM
Lung	44.0 nTPM
Prostate	33.1 nTPM
Bone marrow	32.9 nTPM
Skin	25.7 nTPM
PBMC	25.5 nTPM
Skeletal muscle	18.9 nTPM
Breast	17.5 nTPM
Spleen	15.8 nTPM
Lymph node	15.0 nTPM
Endometrium	12.2 nTPM
Colon	11.4 nTPM
Adipose tissue	11.4 nTPM
Stomach	6.8 nTPM

Undifferentiated cells	0.8 nTPM
Colon	2.4 nTPM
Rectum	0.2 nTPM
Small intestine	0.0 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC