Single cell type - PIK3C2A - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PIK3C2A
Gene descriptionⁱ Full gene name according to HGNC.	Phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Metabolic proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Cardiomyocytes - Nuclear processes (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Astrocytes)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Astrocytes)

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PIK3C2A is part of cluster 43 Cardiomyocytes - Nuclear processes with confidenceⁱ 1
192 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
ENDOU	Endonuclease, poly(U) specific	0.5873	44
HIF3A	Hypoxia inducible factor 3 subunit alpha	0.5756	14
OR2A7	Olfactory receptor family 2 subfamily A member 7	0.5663	43
SHANK3	SH3 and multiple ankyrin repeat domains 3	0.5658	14
INSYN2B	Inhibitory synaptic factor family member 2B	0.5657	43
SHOC1	Shortage in chiasmata 1	0.5586	43
PCDHA8	Protocadherin alpha 8	0.5347	43
OR2A4	Olfactory receptor family 2 subfamily A member 4	0.5340	43
DIPK2B	Divergent protein kinase domain 2B	0.5286	43
ZNF264	Zinc finger protein 264	0.5281	43
F8	Coagulation factor VIII	0.5265	14
FAM156B	Family with sequence similarity 156 member B	0.5245	43
AC026464.6	Novel protein, COG8-PDF readthrough	0.5232	43
NPIPA7	Nuclear pore complex interacting protein family member A7	0.5218	43
PTPRB	Protein tyrosine phosphatase receptor type B	0.5215	14

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	93.2 nTPM
Adipose tissue	116.2 nTPM
Breast	70.3 nTPM

Alveolar cells type 1	76.9 nTPM
Lung	76.9 nTPM

Alveolar cells type 2	62.0 nTPM
Lung	62.0 nTPM

B-cells	25.0 nTPM
Stomach	32.2 nTPM
Lymph node	31.7 nTPM
Adipose tissue	31.1 nTPM
Bone marrow	27.8 nTPM
Spleen	26.9 nTPM
Colon	22.3 nTPM
Breast	21.3 nTPM
Liver	19.1 nTPM
Kidney	19.0 nTPM
PBMC	18.6 nTPM

Basal keratinocytes	35.3 nTPM
Skin	35.3 nTPM

Dendritic cells	29.5 nTPM
Adipose tissue	50.6 nTPM
PBMC	20.0 nTPM
Breast	17.8 nTPM

Endothelial cells	87.6 nTPM
Heart muscle	209.3 nTPM
Lung	131.0 nTPM
Esophagus	115.2 nTPM
Skeletal muscle	112.3 nTPM
Endometrium	110.2 nTPM
Prostate	92.9 nTPM
Testis	92.4 nTPM
Liver	84.4 nTPM
Skin	70.5 nTPM
Breast	60.3 nTPM
Ovary	46.4 nTPM
Eye	46.1 nTPM
Placenta	35.8 nTPM
Pancreas	19.3 nTPM

Fibroblasts	28.6 nTPM
Heart muscle	54.9 nTPM
Lung	35.7 nTPM
Skeletal muscle	32.5 nTPM
Prostate	31.3 nTPM
Adipose tissue	27.6 nTPM
Esophagus	26.3 nTPM
Stomach	23.7 nTPM
Breast	23.3 nTPM
Skin	22.3 nTPM
Ovary	19.4 nTPM
Placenta	17.6 nTPM

Intestinal goblet cells	23.5 nTPM
Rectum	25.8 nTPM
Colon	25.0 nTPM
Small intestine	19.6 nTPM

Macrophages	27.0 nTPM
Ovary	50.9 nTPM
Adipose tissue	46.8 nTPM
Bone marrow	41.2 nTPM
Skeletal muscle	35.8 nTPM
Prostate	31.0 nTPM
Endometrium	30.0 nTPM
Spleen	27.0 nTPM
Testis	26.7 nTPM
Lung	26.2 nTPM
Breast	25.1 nTPM
Esophagus	23.6 nTPM
Kidney	18.1 nTPM
Stomach	14.7 nTPM
Pancreas	7.7 nTPM
PBMC	0.0 nTPM

Paneth cells	13.1 nTPM
Rectum	18.6 nTPM
Colon	13.2 nTPM
Small intestine	7.5 nTPM

Plasma cells	29.9 nTPM
Adipose tissue	56.8 nTPM
Stomach	33.5 nTPM
Spleen	24.0 nTPM
Bone marrow	23.0 nTPM
Esophagus	12.3 nTPM

Respiratory ciliated cells	26.4 nTPM
Lung	32.1 nTPM
Bronchus	20.6 nTPM

Smooth muscle cells	35.1 nTPM
Heart muscle	71.9 nTPM
Breast	40.0 nTPM
Endometrium	38.0 nTPM
Esophagus	37.2 nTPM
Skeletal muscle	36.9 nTPM
Adipose tissue	35.3 nTPM
Skin	34.2 nTPM
Prostate	33.4 nTPM
Ovary	30.0 nTPM
Bronchus	17.9 nTPM
Pancreas	11.1 nTPM

T-cells	25.3 nTPM
Lung	42.6 nTPM
Adipose tissue	37.6 nTPM
Endometrium	35.9 nTPM
Skeletal muscle	32.6 nTPM
Spleen	31.4 nTPM
Lymph node	28.7 nTPM
Bone marrow	24.9 nTPM
Stomach	24.2 nTPM
Ovary	22.3 nTPM
Colon	21.9 nTPM
Skin	21.2 nTPM
Esophagus	19.7 nTPM
Breast	19.6 nTPM
Liver	19.3 nTPM
Prostate	19.0 nTPM
PBMC	14.8 nTPM
Kidney	14.4 nTPM

Astrocytes	217.4 nTPM
Brain	217.4 nTPM

Collecting duct cells	36.8 nTPM
Kidney	36.8 nTPM

Cone photoreceptor cells	70.9 nTPM
Eye	70.9 nTPM

Cytotrophoblasts	29.6 nTPM
Placenta	29.6 nTPM

Undifferentiated cells	20.7 nTPM
Rectum	24.4 nTPM
Colon	21.3 nTPM
Small intestine	16.4 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC