Single cell type - PPP5C - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PPP5C
Gene descriptionⁱ Full gene name according to HGNC.	Protein phosphatase 5 catalytic subunit
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes Metabolic proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity. Read more	Non-specific - Transcription (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Immune cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines. Read more	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines. Read more	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUES OVERVIEWⁱ An overview of all tissues where single cell type expression has been analyzed. Each tissue name and corresponding UMAP plot is clickable and redirects to the selected tissue.
Adipose tissue Bone marrow Brain Breast Bronchus Colon Endometrium Esophagus Eye Heart muscle Kidney Liver Lung Lymph node Ovary Pancreas Placenta Prostate Rectum Skeletal muscle Skin Small intestine Spleen Stomach Testis

EXPRESSION CLUSTERING & CORRELATIONⁱ

PPP5C is part of cluster 59 Non-specific - Transcription with confidenceⁱ 1
354 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell type RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data. Read more	Clusterⁱ ID of the expression cluster of the neighboring gene. Read more
MTFP1	Mitochondrial fission process 1	0.5334	59
ARPC4-TTLL3	ARPC4-TTLL3 readthrough	0.5252	59
CDK4	Cyclin dependent kinase 4	0.5217	39
RAB1B	RAB1B, member RAS oncogene family	0.5185	53
TRDV2	T cell receptor delta variable 2	0.5159	58
TRGV9	T cell receptor gamma variable 9	0.5159	58
KIR2DL4	Killer cell immunoglobulin like receptor, two Ig domains and long cytoplasmic tail 4	0.5095	58
RAVER1	Ribonucleoprotein, PTB binding 1	0.5089	59
PPP2R1A	Protein phosphatase 2 scaffold subunit Aalpha	0.5045	53
MSH5	MutS homolog 5	0.4957	59
KLRC3	Killer cell lectin like receptor C3	0.4880	63
POLR1A	RNA polymerase I subunit A	0.4842	59
OVCA2	OVCA2 serine hydrolase domain containing	0.4822	59
CCDC124	Coiled-coil domain containing 124	0.4756	39
ATAD3A	ATPase family AAA domain containing 3A	0.4735	39

SINGLE CELL TISSUESⁱ Single cell RNA levels of annotated cell type clusters are shown separately for each analyzed tissue. For easier navigation across tissues, use the above Single cell tissue overview, where each tissue name and UMAP plot is clickable and redirects to the selected tissue, alternatively the grey browser on the left side of the window. Barchart shows nTPM levels in each annotated cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Adipose tissue
Cluster Expression Alphabetical Bone marrow
Cluster Expression Alphabetical Brain
Cluster Expression Alphabetical Breast
Cluster Expression Alphabetical Bronchus
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Endometrium
Cluster Expression Alphabetical Esophagus
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Lymph node
Cluster Expression Alphabetical Ovary
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skeletal muscle
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Spleen
Cluster Expression Alphabetical Stomach
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ

Organ

Expression

Alphabetical

Adipocytes	28.1 nTPM
Adipose tissue	34.9 nTPM
Breast	21.3 nTPM

Alveolar cells type 1	6.4 nTPM
Lung	6.4 nTPM

Alveolar cells type 2	12.5 nTPM
Lung	12.5 nTPM

Astrocytes	22.9 nTPM
Brain	22.9 nTPM

B-cells	16.5 nTPM
Spleen	26.7 nTPM
Lymph node	21.8 nTPM
Liver	20.0 nTPM
Bone marrow	19.6 nTPM
Breast	16.0 nTPM
Colon	14.4 nTPM
Kidney	14.3 nTPM
Stomach	14.1 nTPM
Adipose tissue	12.0 nTPM
PBMC	5.7 nTPM

Dendritic cells	12.3 nTPM
Adipose tissue	19.7 nTPM
Breast	17.1 nTPM
PBMC	0.0 nTPM

Endothelial cells	19.6 nTPM
Placenta	42.6 nTPM
Ovary	38.6 nTPM
Endometrium	24.9 nTPM
Esophagus	24.2 nTPM
Breast	21.7 nTPM
Testis	21.4 nTPM
Prostate	17.8 nTPM
Skeletal muscle	17.6 nTPM
Pancreas	15.5 nTPM
Skin	15.3 nTPM
Eye	13.7 nTPM
Liver	12.8 nTPM
Heart muscle	4.4 nTPM
Lung	3.1 nTPM

Fibroblasts	17.6 nTPM
Ovary	36.7 nTPM
Placenta	33.2 nTPM
Stomach	22.3 nTPM
Adipose tissue	20.1 nTPM
Esophagus	17.5 nTPM
Skin	14.7 nTPM
Skeletal muscle	14.6 nTPM
Breast	11.6 nTPM
Heart muscle	9.5 nTPM
Prostate	8.6 nTPM
Lung	4.5 nTPM

Intestinal goblet cells	17.0 nTPM
Rectum	21.1 nTPM
Colon	20.1 nTPM
Small intestine	9.9 nTPM

Macrophages	11.9 nTPM
Bone marrow	21.2 nTPM
Pancreas	17.8 nTPM
Stomach	17.6 nTPM
Endometrium	16.1 nTPM
Esophagus	15.8 nTPM
Ovary	13.3 nTPM
Spleen	12.5 nTPM
Kidney	12.0 nTPM
Adipose tissue	10.4 nTPM
Prostate	10.3 nTPM
Breast	8.9 nTPM
Testis	8.1 nTPM
Skeletal muscle	7.3 nTPM
Lung	6.9 nTPM
PBMC	0.0 nTPM

Paneth cells	17.0 nTPM
Rectum	26.6 nTPM
Colon	13.2 nTPM
Small intestine	11.3 nTPM

Plasma cells	25.5 nTPM
Bone marrow	44.5 nTPM
Spleen	36.5 nTPM
Stomach	24.5 nTPM
Esophagus	12.3 nTPM
Adipose tissue	9.7 nTPM

Respiratory ciliated cells	14.6 nTPM
Bronchus	18.9 nTPM
Lung	10.2 nTPM

Smooth muscle cells	19.9 nTPM
Pancreas	53.2 nTPM
Adipose tissue	25.6 nTPM
Prostate	23.1 nTPM
Skeletal muscle	22.8 nTPM
Ovary	18.8 nTPM
Esophagus	18.6 nTPM
Skin	16.4 nTPM
Endometrium	16.3 nTPM
Breast	13.5 nTPM
Bronchus	6.6 nTPM
Heart muscle	4.3 nTPM

T-cells	20.4 nTPM
Stomach	45.0 nTPM
Bone marrow	38.2 nTPM
Esophagus	32.8 nTPM
Spleen	29.8 nTPM
Lymph node	25.2 nTPM
Endometrium	24.1 nTPM
Colon	23.7 nTPM
Kidney	21.2 nTPM
Liver	21.2 nTPM
Ovary	17.8 nTPM
Breast	15.5 nTPM
Skeletal muscle	14.7 nTPM
Lung	12.2 nTPM
Adipose tissue	11.0 nTPM
PBMC	9.3 nTPM
Skin	5.0 nTPM
Prostate	0.0 nTPM

Basal keratinocytes	9.4 nTPM
Skin	9.4 nTPM

Basal prostatic cells	16.6 nTPM
Prostate	16.6 nTPM

Basal respiratory cells	20.9 nTPM
Bronchus	20.9 nTPM

Cholangiocytes	44.3 nTPM
Liver	44.3 nTPM

Undifferentiated cells	25.0 nTPM
Rectum	26.8 nTPM
Colon	25.7 nTPM
Small intestine	22.5 nTPM

Adipose tissue

Bone marrow

Brain

Breast

Bronchus

Colon

Endometrium

Esophagus

Eye

Heart muscle

Kidney

Liver

Lung

Lymph node

Ovary

Pancreas

Placenta

Prostate

Rectum

Skeletal muscle

Skin

Small intestine

Spleen

Stomach

Testis

PBMC